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Sample records for publica founder taagepera

  1. The purifying bridge of Res Publica / Rein Taagepera

    Index Scriptorium Estoniae

    Taagepera, Rein, 1933-

    2004-01-01

    Res Publica edust Eesti poliitilisel maastikul. Autor käsitleb Res Publicat kui puhastava toimega ja silla funktsiooni täitvat parteid, mis üritab siduda tervikuks Keskerakonna ja Reformierakonna seisukohad

  2. Rein Taagepera lahkub Res Publicast / Kristjan Roos

    Index Scriptorium Estoniae

    Roos, Kristjan, 1978-

    2005-01-01

    Res Publica asutaja Rein Taagepera, Jaan Einasto, Mare Taagepera ja Lauri Aaspõllu lahkuvad Res Publicast, kuna erakond on nende väitel muutunud paremtsentrist paremäärmuslikuks. Vt. samas: Erakonnad hoiavad uksed valla

  3. Padenije Res Publica / Viktoria Jürmann

    Index Scriptorium Estoniae

    Jürmann, Viktoria

    2005-01-01

    Res Publica üks rajajatest, Rein Taagepera, lahkus parteist, süüdistades erakonda paremtsentristlikust maailmavaatest loobumises. Res Publica Riigikogu fraktsioon tahab avaldada umbusaldust haridus- ja teadusminister Mailis Repsile

  4. Riigikogulased ongi teistmoodi asendis. Aga mitte nii teistmoodi, kui nad hetkel arvavad / Rein Taagepera ; interv. Urmo Soonvald

    Index Scriptorium Estoniae

    Taagepera, Rein, 1933-

    2007-01-01

    Politoloog Rein Taagepera vastab Riigikogu suurust, tööd ning seaduseelnõu, mis vabastab parlamendiliikmed kuluhüvitiste avalikustamisest, puudutavatele küsimustele. Lisa: Soome parlamendist õpitakse kulutamist, mitte tööl käimist; Rein Taagepera: teadlane, presidendikandidaat, Res Publica looja

  5. Res Publica jäi järjekordselt ilma mitmest nimekast liikmest / Tuuli Koch, Kärt Anvelt

    Index Scriptorium Estoniae

    Koch, Tuuli

    2005-01-01

    Oma lahkumiset Res Publicast teatasid erakonna esimene esimees Rein Taagepera, tema abikaasa Mare Taagepera, akadeemik Jaan Einasto ja 2002. aastal erakonna esimeheks kandideerinud Lauri Aaspõllu. Rein Taagepera põhjendas otsust Res Publica liikumisega paremtsentrist paremäärmusse. Lisa: Tuntud inimesi, kes seni Res Publicast lahkunud. Vt. samas lühiintervjuud Jaan Einastoga: Res Publica peab tegema koostööd

  6. Rein Taagepera : "Euroopa peab muutuma föderatsiooniks" / Rein Taagepera ; interv. Teet Korsten

    Index Scriptorium Estoniae

    Taagepera, Rein, 1933-

    2008-01-01

    Ilmunud ka: Severnoje Poberezhje : Subbota 16. aug. lk. 5. Eesti/USA politoloog muutustest Eestis, Uppsala ülikooli Skytte auhinnast, konverentsist "Diasporaa roll Eesti iseseisvuse taastamisel?". Arvamust avaldab parlamendiliige Peeter Tulviste. Lisa: Rein Taagepera CV

  7. Balti "Ungari tee" taotlus 1965 / Rein Taagepera

    Index Scriptorium Estoniae

    Taagepera, Rein, 1933-

    2010-01-01

    1965. aastal H. Raagi, H. Susi ja R. Taagepera poolt koostatud ja levitatud satelliitsusmemorandumist, milles toodi välja idee kehtestada Balti riikides rahvademokraatia; Zbigniew Brzezinski rollist memorandumi vahendajana ning selle avaldamisele järgnenud vastukajadest ja tegevustest kuni aastani 1973

  8. Baltic Quest for a Hungarian Path, 1965 / Rein Taagepera

    Index Scriptorium Estoniae

    Taagepera, Rein, 1933-

    2013-01-01

    1965. aastal H. Raagi, H. Susi ja R. Taagepera poolt koostatud ja levitatud satelliitsusmemorandumist, mille idee oli kehtestada Balti riikides rahvademokraatia ja riikidele spetsiaalne satelliitrežiim; Zbigniew Brzezinski rollist memorandumi vahendajana; memorandumi mõju nende autorite eludele

  9. Taagepera avastas mõned loodusseadused / Margus Välja

    Index Scriptorium Estoniae

    Välja, Margus, 1958-

    2009-01-01

    Eesti teadlane Rein Taagepera rääkis Los Angelese Eesti Majas kolmest ühiskondlikust loodusseadusest, mille avastamisel võis olla määrav tähtsus, et talle anti 2008. a. Uppsala ülikooli Skytte sihtasutuse väljaantav Skytte auhind

  10. R. Taagepera ja M. S. Shugart valimissüsteemidest / Peet Kask

    Index Scriptorium Estoniae

    Kask, Peet, 1948-

    1989-01-01

    Rein Taagepera ja Matthew Soberg Shugarti raamatust "Häältest mandaatideni: valimissüsteemide mõjud ja mõjutajad", mis ilmus inglise keeles 1989. a. Londonis (Seats and votes: the effects and determinants of electoral systems) ning annab ülevaate parlamendivalimistel kasutatavate süsteemide tüüpidest, komponentidest, nende uurimise ajaloost ja hetkeseisust

  11. Res Publica aps / Erkki Bahovski

    Index Scriptorium Estoniae

    Bahovski, Erkki, 1970-

    2003-01-01

    Autori sõnul tekitavad tänavatel ülesseatud postrid, kus peaminister Juhan Parts kutsub üles ütlema "jah" Euroopa Liidule, kummastust, sest ehkki on tegemist Res Publica kampaaniaga, on tavainimesel raske vahet teha valitsuse justkui neutraalse referendumikampaania ja Res Publica "jah"-kampaania vahel

  12. Lõhe Res Publicas / Eve Heinla

    Index Scriptorium Estoniae

    Heinla, Eve, 1966-

    2005-01-01

    Tallinna linnapea Tõnis Palts on vastu Tallinna volikogu Res Publica fraktsiooni esimehe Toomas Tautsi abikaasa Kristina Tautsi tööleasumisele Lääne-Tallinna keskhaigla haldusjuhina. T. Paltsi kirjast Res Publica Tallinna piirkonna juhatusele. Lisa: Kuidas lahvatas pealinna võimutüli. Kommenteerivad: Maret Maripuu, Tõnis Palts, Vladimir Maslov

  13. Res Publica objedinjajetsja s Sojuzom Otetshestva

    Index Scriptorium Estoniae

    2006-01-01

    Res Publica ja Isamaaliidu liitumisel tekib uus erakond - Eesti Eest!. Ida-Viru Isamaaliidu ja Res Publica esimeeste Hans Pindre, Vladislav Ponjatovski ning Narva Res Publica endise liidri Nikolai Golubevi arvamused

  14. A European Res publica

    Directory of Open Access Journals (Sweden)

    Ola Zetterquist

    2011-05-01

    Full Text Available The article analyses the fundamental constitutional enigma of the European Union (EU, namely whether the EU can be considered as a (from its Member States separate and independent constitutional legal order. The EU is often referred to as a legal order sui generis, i.e. of a unique character that defies traditional definitions. More specifically, the notion of an independent and separate EU is at odds with the idea of the sovereign state. The notion of the EU as a legal order sui generis is too much influenced by the models of the sovereign state and sovereignty (in the vein of Thomas Hobbes. The key component in the Hobbesian idea of sovereignty is freedom as non-interference. A sovereign state is consequently a state that is free from, i.e. not interfered with by, external actors like, for example, the EU. Put differently, either the EU is sovereign or the Member States are sovereign. By shifting the perspective to a neo-Roman republican understanding of freedom as non-domination the constitutional picture of the EU will become more nuanced. Res publica is best understood as what citizens hold in common and above their narrow self-interest. According to a republican notion of the constitution the purpose of the law is to eliminate the possibility of arbitrary domination. For that reason, not all interference is to be considered as a restriction of freedom but only those restrictions that cannot be justified according to the res publica. Viewed through the republican prism it can be argued that the EU represents an important advancement in securing freedom as non-domination without implying that the EU must become a state. The fundamental enigma can thus be rephrased as a clash between two diverging concepts of freedom. Whereas the EU will always be at odds with the idea of sovereignty (however framed it will be much easier to reconcile with the republican ideal. DOWNLOAD THIS PAPER FROM SSRN: http://ssrn.com/abstract=1837332

  15. Res Publica v respublike / Roman Gornev

    Index Scriptorium Estoniae

    Gornev, Roman

    2002-01-01

    Järg 29. november nr. 48 lk. 7. Res Publica - uue poliitika partei. Res Publica Ida-Virumaal, partei juhtfiguurid, Res Publica Kohtla-Järvel. Koalitsioonileping Keskerakonnaga viis konfliktini partei juhtkonnaga. Kohtla-Järve Res Publica kohaliku organisatsiooni konflikti partei juhtkonnaga kommenteerib Hants Hint

  16. Res Publica kogub uut hoogu / Andres Jalak

    Index Scriptorium Estoniae

    Jalak, Andres, 1953-

    2005-01-01

    Kommenteerides Res Publica senise esimehe ja endise peaministri Juhan Partsi ning uueks esimeheks valitud Taavi Veskimäe kõnet Res Publica üldkogul, väljendab Res Publica fraktsiooni aseesimees usku, et Res Publica juhtimisel suudetakse 2007. aasta parlamendivalimistel taastada tulevikku suunatud mõtlemisega valitsus

  17. Mida ootame Res Publica poliitikutelt? / Andreas Kaju

    Index Scriptorium Estoniae

    Kaju, Andreas

    2003-01-01

    Res Publica Juventus on piirkondadele saadetud küsitlustega otsinud vastuseid mitmetele probleemidele. Eesmärk Res Publica poliitilise käitumise raamide määramine. Tabel: Juventuse küsimused piirkondadele

  18. Rahvaliit likvideerib Res Publica veeuputust / Janno Reiljan

    Index Scriptorium Estoniae

    Reiljan, Janno, 1951-2018

    2005-01-01

    Ilmunud ka: Molodjozh Estonii 1. august lk. 5. Selgitused Res Publica esimehe Taavi Veskimägi artiklile 25. juuli Postimehes "Pärast meid tulgu või veeuputus". Res Publica ja Rahvaliidu poliitika võrdlus

  19. Miks Res Publica kaotas / Juhan Parts

    Index Scriptorium Estoniae

    Parts, Juhan, 1966-

    2004-01-01

    Ilmunud ka: Severnoje Poberezhje, 29. juuni 2004, lk. 2; Koit, 29. juuni 2004, lk. 6. Europarlamendi valimiste tulemused erakonnale Res Publica. Juhan Partsi kõne 26. juunil Pärnus toimunud Res Publica volikogul. Lühendatult

  20. Res Publica esitas avalduse kaposse / Virkko Lepassalu

    Index Scriptorium Estoniae

    Lepassalu, Virkko, 1971-

    2003-01-01

    Kaposse jõudis Res Publica avaldus, milles palutakse uurida erakonda seadusvastaselt anonüümselt sponsoreerima kutsuva kirja tagamaid. Vt. ka Äripäev 19. veebruar lk. 6 "Kapo ei alustanud Res Publica avalduse peale kriminaalmenetlust"

  1. 10 teesi Res Publica valitsemisprogrammist aastani 2007

    Index Scriptorium Estoniae

    2004-01-01

    Ilmunud ka: Ottshjot narodu Estonii. Res Publica 2003, 2004, lk. 4-5, 8-9. Res Publica valitsemisprogrammi lubadustest ja täitmisest. Vt. lk. 8-9 Res Publica ministrite olulisemad tegevused 2004. aastal - lühiülevaate teevad Ken-Marti Vaher, Taavi Veskimägi, Marko Pomerants, Toivo Maimets

  2. Isamaaliidu ühinemisjutt ajas Res Publica keema / Toomas Sildam

    Index Scriptorium Estoniae

    Sildam, Toomas, 1961-

    2005-01-01

    Ilmunud ka: Postimees : na russkom jazõke 14. nov., lk 3. Isamaaliidu esimehe Tõnis Lukase ettepanekut Isamaaliidu ja Res Publica ühinemiseks pooldavad ka Res Publica eestseisuse liikmed Juhan Parts ja Tõnis Palts, kuid Res Publica esimehe Taavi Veskimäe kinnitusel läheb Res Publica 2007. aasta parlamendivalimistele vastu iseseisvalt. Lisa: Isamaaliit ja Res Publica

  3. Res Publica soolo rikkus tavasid / Kai Kalamees

    Index Scriptorium Estoniae

    Kalamees, Kai

    2005-01-01

    Riigikogu aseesimeheks valiti Res Publica liige Taavi Veskimägi, nüüd on Riigikogu juhatuses kaks ühe partei liiget. Riigikogu aseesimeheks tagasi valitud Toomas Vareki hinnangul näitab see samm nii Res Publica kogenematust kui ka Eesti poliitilise kultuuri kehva taset

  4. Res Publica otsib kandepinda / Mirko Ojakivi

    Index Scriptorium Estoniae

    Ojakivi, Mirko

    2004-01-01

    Res Publica peasekretäri Ott Lumi sõnul on erakond teinud tõsised järeldused Euroopa Parlamendi valimiste tulemusest. Res Publica parlamendifraktsiooni väljasõidul pidas kriitilise kõne erakonna esimees Juhan Parts

  5. Do (Female) Founders Influence (Female) Joiners to Become Founders too?

    DEFF Research Database (Denmark)

    Rocha, Vera; Van Praag, Mirjam

    -founder (gender) homophily affects the likelihood of female and male joiners to become founders themselves. We find a relatively large and robust positive effect among female joiners that can be attributed to the role modeling function of female founders. Female entrepreneurs hiring personnel may thus have...

  6. Founder Mutations in Xeroderma Pigmentosum

    Science.gov (United States)

    Tamura, Deborah; DiGiovanna, John J.; Kraemer, Kenneth H.

    2012-01-01

    In this issue, Soufir et al. report a founder mutation in the XPC DNA repair gene in 74% of families with xeroderma pigmentosum (XP) in the Maghreb region (Algeria, Morocco, and Tunisia) of northern Africa. These patients have a high frequency of skin cancer. The presence of this founder mutation provides an opportunity for genetic counseling and early diagnosis of XP. PMID:20463673

  7. Parts ei soovi Res Publica esimehe ametit / Tuuli Koch

    Index Scriptorium Estoniae

    Koch, Tuuli

    2005-01-01

    Kõige tõenäolisem kandidaat Res Publica juhi kohale on Taavi Veskimägi, aseesimeesteks kandideerivad Marko Mihkelson ja Henn Pärn. Res Publica fraktsiooni koosolekul leidis Mihhail Lotman, et erakond võiks olla feminiinsem

  8. Res Publica meelitab valla- ja linnajuhte / Henrik Roonemaa

    Index Scriptorium Estoniae

    Roonemaa, Henrik

    2001-01-01

    Valitsusliidu regionaalpoliitikas pettunud 30 omavalitsusjuhti on astunud ühenduse Res Publica liikmeks, lootes selle põhjal tekkiva partei abil kohaliku ja riigivõimu taas omavahel suhtlema panna. Vt. samas Res Publica liikmetest omavalitsusjuhid

  9. Kes tegelikult lõid Res Publica? / Valeri Kalabugin

    Index Scriptorium Estoniae

    Kalabugin, Valeri

    2005-01-01

    Enne erakonnaks kuulutamist oli Res Publica Eesti iseseisvust ja demokraatiat taotlev ühendus, kuhu on kuulunud mitmed poliitika- ning ühiskonnategelased. Vt. samas: Ühendus Res Publica avaldus. Küsimustele vastavad Res Publica avalike suhete juht Riina Vändre, Riigikogu liige Mart Nutt, ajakirjanik Toomas Kümmel

  10. Juhan Parts soovib Res Publica tagasi tippu viia / Toomas Sildam

    Index Scriptorium Estoniae

    Sildam, Toomas, 1961-

    2004-01-01

    Res Publica esimees peaminister Juhan Parts plaanib minna oma erakonnaga kohalikele valimistele ning uurib võimalusi paremerakondade ühinemiseks. Rakveres toimunud erakonna üldkogust. Lisad: Peaministri neli rasket hetke; Res Publica ministrid said parteilt toetuse. Vt. samas: Reformierakond kiitis Res Publicat hea koostöö eest; Parts: 191 vastuhäält on hea tulemus

  11. Res Publica Euroopas / Eiki Berg, Marko Mihkelson ; interv. Lauri Lugna

    Index Scriptorium Estoniae

    Berg, Eiki, 1970-

    2003-01-01

    Res Publica välispoliitika eksperdid Eiki Berg ja Marko Mihkelson vastavad küsimustele, mis käsitlevad Res Publica saamist Euroopa Rahvapartei (ERP) liikmeks, koostööd ERP-ga, EL-i põhiseaduslikku lepet

  12. Res Publica viskab Oleg Rebase välja

    Index Scriptorium Estoniae

    2006-01-01

    Res Publica Tallinna piirkonna juhatus leidis, et Oleg Rebane läks Keskerakonna provokatsiooniga kaasa minnes vastuollu Res Publica põhimõtetega. Tallinna linnapea Jüri Ratase suhtes algatatud umbusaldushääletuse põhjustest. Sven Sester vastab küsimusele, mis seotud Oleg Rebase ja Tõnis Bittmani juhtumiga

  13. Res Publica lükkas tagasi Isamaaliidu ühinemisettepaneku / Mirko Ojakivi

    Index Scriptorium Estoniae

    Ojakivi, Mirko

    2005-01-01

    Kuigi Res Publica juhid lükkasid tagasi idee ühineda Isamaaliiduga, on Res Publica valmis koostööks nii Isamaaliidu kui ka kõigi teiste erakondadega. Res Publica parlamendifraktsiooni esimehe Marko Pomerantsi arvamus

  14. Desafios das publicações feministas

    Directory of Open Access Journals (Sweden)

    Carmen Silva

    2013-11-01

    Full Text Available http://dx.doi.org/10.1590/S0104-026X2013000200014 Por ocasião dos 20 anos da Revista Estudos Feministas, busco articular o debate sobreteoria e movimento social para apresentar alguns desafios que estão postos para as publicaçõesfeministas. Trato dos desafios ligados ao reconhecimento, à sustentabilidade, às linhas editoriaise à relação universidade e movimento. Concluo afirmando que o principal desafio daspublicações feministas é articular a produção teórica e as pesquisas feministas às lutas e àsformas organizativas que o movimento feminista constrói em cada contexto histórico.

  15. Isamaa ja Res Publica Liidu plaan / Juhan Parts

    Index Scriptorium Estoniae

    Parts, Juhan, 1966-

    2008-01-01

    Ilmunud ka: Eesti Eest = Za Estoniju : Izdanije objedinenija "Sojuz Otetshestva i Res Publica" 15. mai 2008, lk. 4-5. Eesti majanduse uutest ülesannetest. Kommenteerib: Mart Laar. Vt. samas: IRL-i ettepanekud koalitsioonileppe täienduseks

  16. Normas para publicação

    Directory of Open Access Journals (Sweden)

    Editores INTERthesis

    2014-06-01

    • Sociedade e Meio Ambiente Serão aceitas contribuições nas seguintes modalidades: aArtigo: deve ser original, contribuição de caráter acadêmico e/ou técnico-científico destinada a divulgar resultados de pesquisa científica, de natureza empírica, experimental ou conceitual (mínimo de 12 e máximo de 18 páginas, incluindo títulos, resumos, tabelas, figuras, mapas e referências. b Revisão: avaliação crítica sistematizada da literatura sobre determinado assunto; deve-se citar o objetivo da revisão, especificar (em métodos os critérios de busca na literatura e o universo pesquisado, discutir os resultados obtidos e sugerir estudos no sentido de preencher lacunas do conhecimento atual (mínimo de 12 e máximo de 18 páginas, incluindo títulos, resumos, tabelas, figuras, mapas e referências. cEnsaio: reflexão circunstanciada, com redação adequada ao escopo de uma publicação científica, com maior liberdade por parte do autor para defender determinada posição, que vise aprofundar a discussão ou que apresente nova contribuição/abordagem a respeito de tema relevante (mínimo de 12 e máximo de 18 páginas, incluindo títulos, resumos, tabelas, figuras, mapas e referências. d Resenha: análise crítica sobre livro publicado nos últimos dois anos (até 6 páginas, com as mesmas configurações que se solicita ao texto, incluindo referência bibliográfica completa no cabeçalho. Leia mais nas Instruções aos autores: https://periodicos.ufsc.br/index.php/interthesis/article/view/31715/25904

  17. Alfabetización informacional y biblioteca publica

    OpenAIRE

    José Antonio Gómez Hernández; Cristóbal Pasadas-Urena

    2007-01-01

    Introducción. El objetivo del trabajo es hacer una revisión de la alfabetización informacional en las bibliotecas publicas. Se describe la alfabetización informacional como una competencia básica de las personas para saber encontrar y usar la información adecuada a sus necesidades, independientemente del lugar, soporte o medio utilizado para su transmisión. Se explica las tendencias internacionales y locales para la incorporación de este servicio en las bibliotecas publicas, y se justifica la...

  18. Res Publica tähistab sünnipäeva konverentsiga / Lauri Tankler

    Index Scriptorium Estoniae

    Tankler, Lauri

    2003-01-01

    Ilmunud ka: Võta Võim : na russkom jazõke 3. dets. lk. 3. Res Publica saab 2-aastaseks, mille puhul korraldatakse konverents "Riik ja Res Publica". Vt. samas: Selle aasta veebruaris said kuldmärgid

  19. Res Publica kärbiks võimuorganite koosseise / Argo Ideon

    Index Scriptorium Estoniae

    Ideon, Argo, 1966-

    2002-01-01

    Res Publica taotleb Riigikogu kärpimist 61 liikmeni, lubab kahandada kohalike volikogude koosseise, Tallinna abilinnapeade arvu ja kaotada portfellita ministrite kohad. Vt. samas: Res Publica valimisnimekiri Tallinnas

  20. Res Publica asus Reformierakonda Tallinna võimuliidust tõrjuma / Mirko Ojakivi

    Index Scriptorium Estoniae

    Ojakivi, Mirko

    2005-01-01

    Res Publica Tallinna piirkonna juhatuse liikme Siim Roode sõnul teeb Res Publica Keskerakonna Tallinna piirkonna juhatusele ettepaneku koalitsiooniläbirääkimiste alustamiseks. Lisa: Paltsu ettekäändeks Unicom

  1. Res Publica hakkab kaaluma Kohtla-Järve võimuliidust lahkumist / Erik Gamzejev

    Index Scriptorium Estoniae

    Gamzejev, Erik, 1967-

    2002-01-01

    Ilmunud ka: Severnoje Poberezhje 19. nov. lk. 1. Res Publica eestseisuse ettepanek Kohtla-Järve osakonnale lahkuda koalitsioonist. Osakonna juhatuse otsus esitada Hants Hint volikogu esimehe kandidaadiks. Res Publica liikmete käitumise arutelu aukohtus

  2. Res Publica presidendikandidaatide nimed selguvad neljapäevaks / Rauno Veri, Urmo Kübar

    Index Scriptorium Estoniae

    Veri, Rauno, 1978-

    2006-01-01

    Res Publica, Isamaaliit, Reformierakond, SDE ja Keskerakond otsivad ühist presidendikandidaati, ainsa parlamendierakonnana ei osale läbirääkimistel Rahvaliit. Reformierakonna, SDE presidendikandidaatidest; Res Publica naiskogu ja Väärikate Kogu ühisavaldusest

  3. Sisetülides Res Publica heitis liidu Keskerakonnaga kõrvale / Urmas Seaver

    Index Scriptorium Estoniae

    Seaver, Urmas, 1973-

    2005-01-01

    Res Publica juhatus otsustas toetada senise koalitsiooni jätkamist Tallinnas. Res Publica ja Reformierakonna täiendatud koalitsioonileppest. Reformierakonna Tallinna piirkonna juhi Keit Pentuse hinnang võimutülile. Lisa: Võimuleppe lisa

  4. Res Publica : umbusaldamine võib lõpetada senise koalitsiooni / Villy Paimets

    Index Scriptorium Estoniae

    Paimets, Villy, 1972-

    2005-01-01

    Res Publica erakorraline volikogu avaldas toetust justiitsministrile ja andis peaministrile volitused lõpetada justiitsministri umbusaldamise korral senine koalitsioon ning alustada läbirääkimisi Isamaaliiduga. Lisa: Res Publica toetab Vaherit

  5. Res Publica andis kolmele poliitikule fiktiivse elukoha / Kärt Karpa

    Index Scriptorium Estoniae

    Karpa, Kärt, 1973-

    2002-01-01

    Väidetavalt lasi Res Publica enne kohalikke valimisi ühte Pirita eramajja sisse registreerida Jaanus Rahumäe ja veel kaks Res Publica liiget, et nad saaksid kandideerida Tallinna volikogusse ja Pirita halduskogusse

  6. Reinsalu : Res Publica lisab kiirust / Urmas Reinsalu ; interv. Lauri Tankler

    Index Scriptorium Estoniae

    Reinsalu, Urmas, 1975-

    2004-01-01

    Ilmunud ka: Võta Võim : na russkom jazõke, 28. apr. 2004, lk. 4. Res Publica esikandidaat Urmas Reinsalu erakonna valimiskampaania eesmärkidest, võimalustest nende eesmärkide saavutamiseks ja erakonna valimisprogrammi ning kandidaatide eelistest konkurentide ees

  7. Pettumus Res Publicas algas kirikus antud vandest / Margus Tsahkna

    Index Scriptorium Estoniae

    Tsahkna, Margus, 1977-

    2005-01-01

    Autori sõnul on Res Publica petnud inimeste põhiväärtustele tuginevaid ootusi, Eesti riik kaugeneb kodanikust ja tema elulistest huvidest. Isamaaliit paneb ette asuda tegelike probleemide lahendamisele ning kutsub erakondi üles kaitsma rahvuslikke huve

  8. Res Publica pakub sponsoritele anonüümsust / Virkko Lepassalu

    Index Scriptorium Estoniae

    Lepassalu, Virkko, 1971-

    2003-01-01

    Mõnede tõenäoliselt Res Publica lähedaste ettevõtjate seas levib erakonna nimel rahapalumiskiri, mis lubab sponsorile anonüümsust. Vt. samas: Telefonikõne ettevõtja ja Res Publica aseesimehe Ken-Marti Vaheri vahel ; Teisedki on saanud rahaallikaid varjates ; Res Publica on loobunud reklaamibroneeringutest

  9. Res Publica aukohus heidab juhtidele ette eetikavääratust / Toomas Mattson

    Index Scriptorium Estoniae

    Mattson, Toomas, 1970-

    2002-01-01

    Ilmunud ka: Põhjarannik ; Severnoje Poberezhje 22. november lk. 3;4. Res Publica aukohus arvab, et Res Publica juhid on rikkunud erakonna põhikirja, sisekorda ja eetikakoodeksit Kohtla-Järve juhtumi lahendamisel. Kohtla-Järvel sai linnapeaks riisumiskahtlusega uurimise all olev Valeri Korb tänu Keskerakonna ja Res Publica koalitsioonileppele. Kommenteerib Juhan Kivirähk

  10. Res Publica ladvikus hõõgub võimutüli / Tuuli Koch

    Index Scriptorium Estoniae

    Koch, Tuuli

    2006-01-01

    22. aprillil kogunenud Res Publica volikogu toetas 60 poolthäälega ühe vastu Res Publica ja Isamaaliidu ühinemist. Tõnis Palts teatas volikogul esinedes, et Taavi Veskimägi ei sobi Res Publica poolseks läbirääkimiste juhiks

  11. Res Publicas käärib mäss / Hants Hint

    Index Scriptorium Estoniae

    Hint, Hants

    2002-01-01

    Res Publica eestseisuse liige ja Ida-Viru piirkonna esimees Hants Hint vastab küsimustele Res Publica ja Keskerakonna võimuliidu moodustamisega tekkinud skandaali, Res Publica esimehe Juhan Partsiga kohtumise kohta. Vt. samas: "Korbi toetajaid ootab hukkamõist"

  12. Alfabetización informacional y biblioteca publica

    Directory of Open Access Journals (Sweden)

    José Antonio Gómez Hernández

    2007-01-01

    Full Text Available Introducción. El objetivo del trabajo es hacer una revisión de la alfabetización informacional en las bibliotecas publicas. Se describe la alfabetización informacional como una competencia básica de las personas para saber encontrar y usar la información adecuada a sus necesidades, independientemente del lugar, soporte o medio utilizado para su transmisión. Se explica las tendencias internacionales y locales para la incorporación de este servicio en las bibliotecas publicas, y se justifica la importancia de ello por su conexión con el aprendizaje durante toda la vida, que hace de las bibliotecas un recurso fundamental para la educación no formal e informal de los ciudadanos. Método. Se analiza y describe las publicaciones, modelos conceptuales, proyectos, documentos normativos de asociaciones profesionales y los contenidos de los encuentros científicos y profesionales sobre alfabetización informacional y biblioteca publica. Análisis. Se hace un estudio comparativo de las distintas teorías y proyectos, y se hace una valoración critica confrontando éstas con su aplicación práctica en las bibliotecas. Resultados. A partir del análisis se exponen las tendencias en alfabetización informacional y se proponen tareas básicas para una agenda de desarrollo en las bibliotecas publicas de este servicio. Conclusión. Se propone una agenda comun de todas las bibliotecas, instituciones y profesiones involucradas en la adquisición por individuos y comunidades de las competencias básicas englobadas bajo el concepto de alfabetización continua.

  13. Evaluation of the ProPublica Surgeon Scorecard "Adjusted Complication Rate" Measure Specifications.

    Science.gov (United States)

    Ban, Kristen A; Cohen, Mark E; Ko, Clifford Y; Friedberg, Mark W; Stulberg, Jonah J; Zhou, Lynn; Hall, Bruce L; Hoyt, David B; Bilimoria, Karl Y

    2016-10-01

    The ProPublica Surgeon Scorecard is the first nationwide, multispecialty public reporting of individual surgeon outcomes. However, ProPublica's use of a previously undescribed outcome measure (composite of in-hospital mortality or 30-day related readmission) and inclusion of only inpatients have been questioned. Our objectives were to (1) determine the proportion of cases excluded by ProPublica's specifications, (2) assess the proportion of inpatient complications excluded from ProPublica's measure, and (3) examine the validity of ProPublica's outcome measure by comparing performance on the measure to well-established postoperative outcome measures. Using ACS-NSQIP data (2012-2014) for 8 ProPublica procedures and for All Operations, the proportion of cases meeting all ProPublica inclusion criteria was determined. We assessed the proportion of complications occurring inpatient, and thus not considered by ProPublica's measure. Finally, we compared risk-adjusted performance based on ProPublica's measure specifications to established ACS-NSQIP outcome measure performance (eg, death/serious morbidity, mortality). ProPublica's inclusion criteria resulted in elimination of 82% of all operations from assessment (range: 42% for total knee arthroplasty to 96% for laparoscopic cholecystectomy). For all ProPublica operations combined, 84% of complications occur during inpatient hospitalization (range: 61% for TURP to 88% for total hip arthroplasty), and are thus missed by the ProPublica measure. Hospital-level performance on the ProPublica measure correlated weakly with established complication measures, but correlated strongly with readmission (R = 0.834, P Scorecard is questionable.

  14. Founder of a scientific school on plasma

    International Nuclear Information System (INIS)

    Anon

    2003-01-01

    The academician Mikhail Aleksandrovitch Leontovitch is a physicist-theorist of a wide profile (physical optics, oscillation theory, acoustics, statistical physics, thermodynamics), who became the founder of the largest scientific schools on the radiophysics and plasma physics. Namely due to his effective leadership in developing the theory our theoretical studies on the controlled thermonuclear synthesis reached high level and facilitated the success of the experiment [ru

  15. New Firm Performance and the Replacement of Founder-CEOs

    DEFF Research Database (Denmark)

    Chen, Jing; Thompson, Peter

    2015-01-01

    We study the causes and consequences of the replacement of founder-CEOs in a sample of 4,172 Danish start-ups. We propose that founder-CEO replacement is driven in part by mismatches between business quality and founder ability. Our framework suggests that replacements are more likely among...... the worst- and best-performing firms, with low (high)-ability founders replaced by manager with higher (lower) ability. Replacement is not unambiguously associated with better subsequent performance. Firms that replaced the founder were much more likely to fail, but the surviving firms among them grew...

  16. New Firm Performance and the Replacement of Founders

    DEFF Research Database (Denmark)

    Chen, Jing; Thompson, Peter

    We construct a simple model of founder turnover in which there may be mismatches between the quality of a startup and the ability of the founder. When high-ability founders establish poor-quality businesses, they either choose to close the business or hire a less able CEO. In contrast, low......-ability founders with highquality businesses hire a more able CEO. We derive implications of the model for the relationship between firm performance and founder turnover. These predictions are tested using a large sample of Danish startups....

  17. Publicação Científica

    Directory of Open Access Journals (Sweden)

    Getulio Teixeira Batista

    2006-12-01

    Full Text Available O gerenciamento da editoração da revista científica integrada em um sistema digital que permite o monitoramento de um artigo desde a submissão até a publicação como o Sistema de Editoração Eletrônica de Revistas (SEER, Soares et al., 2004, a partir de qualquer ponto de acesso à Internet, representa um grande avanço no processo de editoração não só pela economia de papel e correio, mas principalmente por agilizar a comunicação do editor com os autores e revisores. É fundamental que o editor fique extremamente atento no fomento dessa interação. A motivação para publicações é muito variável e afeta o processo de publicação nas diferentes fases. Muitos estudantes submetem trabalhos para cumprir exigências de cursos e ao se depararem com o processo de revisão acabam desistindo porque já cumpriram a exigência e não querem investir o tempo necessário exigido pela revisão de seu artigo. Cabe ao editor o papel de incentivador da busca da qualidade. É fundamental que o editor não seja um mero repassador das observações dos avaliadores, mas que as interprete e interaja com os autores para que elas sejam implementadas adequadamente para melhoria da qualidade do artigo. Ao encerrar o primeiro volume, a editoração da Ambi-Água tem a satisfação de manifestar que a interação com os autores e avaliadores foi uma constante, o que resultou num tempo mínimo de processamento da editoração.

  18. Res Publica kõrvaldas mässaja / Kristjan Roos

    Index Scriptorium Estoniae

    Roos, Kristjan, 1978-

    2005-01-01

    Tallinna linnavolikogu Res Publica fraktsiooni juhi kohalt, Res Publica Tallinna piirkonna juhatusest ja erakonna eestseisusest end taandanud Toomas Tautsi sõnul esitati talle erakonna eestseisuses mitmeid süüdistusi, mis kokkuvõtvalt olid etteheited tema vastuseisule võimalikule koalitsioonile Keskerakonnaga. Lisa: Abilinnapeadeks saavad Promm, Reivik ja Pevkur

  19. Res Publica Ida-Viru piirkond valis uue juhatuse / Erik Gamzejev

    Index Scriptorium Estoniae

    Gamzejev, Erik, 1967-

    2002-01-01

    Ilmunud ka: Severnoje Poberezhje 4. dets. lk. 1. Res Publica Ida-Viru piirkonna üldkogul valiti uus juhatus, Vladimir Sarantsevi sõnul oli koosolek enamiku Kohtla-Järve osakonna liikmete arvates õigustühine. Res Publica peasekretäri Tõnis Konsi kommentaare

  20. Res Publica seisab vastu homse arvel elamisele / Siim Männik

    Index Scriptorium Estoniae

    Männik, Siim

    2005-01-01

    Ilmunud ka: Vabariik (venek.) 30. august lk. 1. Res Publica koostab praegu kohalikeks valimisteks nimekirju. Erakond ei plaani korraldada mitte ühte üleriigilist valimiskampaaniat, vaid 120 kohalikku kampaaniat, peale selle on kavas üleriigiline n.-ö. foonikampaania. Lisa: Miks valida Res Publica? Vt. samas: Sisevalimised 1.-3. septembrini

  1. Presidendilossis pidutses ka üks Res Publica liige / Kadri Jakobson

    Index Scriptorium Estoniae

    Jakobson, Kadri, 1970-

    2006-01-01

    SL Õhtulehele presidendilossis toimunud noortepidudest rääkinud neiu on Res Publica liige, kuid tema sõnul pole tema parteiline kuuluvus pidudega seotud. Arvamust avaldavad Res Publica juhatuse liige Andreas Kaju, erakonna esimees Taavi Veskimägi, ERL-i pressiesindaja Agu Uudelepp jt.

  2. Res Publica mängis topeltmängu / Risto Berendson

    Index Scriptorium Estoniae

    Berendson, Risto, 1975-

    2005-01-01

    Res Publica jätkab koostööd Tallinna linnavalitsuses Reformierakonnaga. Tallinna linnapea Tõnis Paltsi sõnul oli paralleelsete läbirääkimiste pidamine Keskerakonna ja Reformierakonnaga Res Publica Tallinna piirkonna juhatuse valitud taktika. Kommenteerib Jaanus Piirsalu

  3. Res Publica toetus pole aastaga üle viie protsendi tõusnud / Tuuli Koch

    Index Scriptorium Estoniae

    Koch, Tuuli

    2006-01-01

    Emori jaanuarikuu küsitluse põhjal on 22 protsendiga suurim toetajaskond Keskerakonnal, Res Publica reiting on aasta aega püsinud viie ja kolme toetusprotsendi vahel. Vt. samas: Taavi Veskimägi. 2 küsimust. Diagrammid: Res Publica valiks riigikogusse tagasi vaid kolm protsenti valijaist; Toetus Res Publicale

  4. Ühendpartei Res Publica tiib oli häältekogumisel Isamaast pisut edukam

    Index Scriptorium Estoniae

    2007-01-01

    Ühenderakonna Res Publica tiiva kandidaadid said Riigikogu valimistel umbes tuhat häält rohkem kui Isamaaliidu tiiva kandidaadid, samas oli IRL-i valimisnimekirjas Res Publica tiiva kandidaate ka mõne inimese võrra rohkem. Isamaaliidu edukaimad hääletoojad

  5. Res Publica lihtliikmed tõrjuvad Veskimäge / Tuuli Koch

    Index Scriptorium Estoniae

    Koch, Tuuli

    2006-01-01

    Ilmunud ka: Pärnu Postimees 17. okt. lk. 6. Isamaa ja Res Publica liidu peaministrikandidaadiks sai Mart Laar, kuid pinged erakondade sees kestavad edasi. Res Publica opositsioon toetab isamaaliitlast Mart Laari ja on Taavi Veskimäe vastu. Lisa: Otsitakse peaministrit

  6. Fides Publica in Ancient Rome and its Reception by Grotius and Locke

    NARCIS (Netherlands)

    de Wilde, M.

    2011-01-01

    The article analyzes the Roman notion of des publica and its reception by Grotius and Locke. The Romans considered des publica a general standard of behavior for all those invested with state power. It was regarded as a legal norm with moral connotations, which applied especially, though not

  7. The reality and importance of founder speciation in evolution.

    Science.gov (United States)

    Templeton, Alan R

    2008-05-01

    A founder event occurs when a new population is established from a small number of individuals drawn from a large ancestral population. Mayr proposed that genetic drift in an isolated founder population could alter the selective forces in an epistatic system, an observation supported by recent studies. Carson argued that a period of relaxed selection could occur when a founder population is in an open ecological niche, allowing rapid population growth after the founder event. Selectable genetic variation can actually increase during this founder-flush phase due to recombination, enhanced survival of advantageous mutations, and the conversion of non-additive genetic variance into additive variance in an epistatic system, another empirically confirmed prediction. Templeton combined the theories of Mayr and Carson with population genetic models to predict the conditions under which founder events can contribute to speciation, and these predictions are strongly confirmed by the empirical literature. Much of the criticism of founder speciation is based upon equating founder speciation to an adaptive peak shift opposed by selection. However, Mayr, Carson and Templeton all modeled a positive interaction of selection and drift, and Templeton showed that founder speciation is incompatible with peak-shift conditions. Although rare, founder speciation can have a disproportionate importance in adaptive innovation and radiation, and examples are given to show that "rare" does not mean "unimportant" in evolution. Founder speciation also interacts with other speciation mechanisms such that a speciation event is not a one-dimensional process due to either selection alone or drift alone. (c) 2008 Wiley Periodicals, Inc.

  8. Corporate Social Responsibility in Large Family and Founder Firms

    NARCIS (Netherlands)

    J.H. Block (Jörn); M. Wagner (Marcus)

    2010-01-01

    textabstractBased on arguments about long-term orientation and corporate reputation, we argue that family and founder firms differ from other firms with regard to corporate social responsibility. Using Bayesian analysis, we then show that family and founder ownership are associated with a lower

  9. Res Publica ja Isamaaliit ühendavad jõud / Urmo Kübar, Rauno Veri

    Index Scriptorium Estoniae

    Kübar, Urmo, 1978-

    2006-01-01

    Res Publica esimees Taavi Veskimägi ja Isamaaliidu esimees Tõnis Lukas kirjutasid alla ühiste kavatsuste deklaratsioonile, milles nad teevad ettepaneku moodustada ühine erakond. Lisad: Erakonna Eesti Eest deklaratsioon; Lühiülevaade ajaloost

  10. Res Publica üldkogu hääletab poliitilisi resolutsioone / Lauri Tankler

    Index Scriptorium Estoniae

    Tankler, Lauri

    2004-01-01

    Res Publica üldkogul hääletusele pandavate resolutsioonide eesmärgiks on teavitada avalikkust erakonna seisukohtadest. Olulisemad resolutsioonid on ette valmistatud ideoloogia, majanduse, hariduse ja sotsiaalpoliitika valdkonnas

  11. Res Publica nõuab Leinatammelt 44 600 krooni / Kadri Jakobson

    Index Scriptorium Estoniae

    Jakobson, Kadri, 1970-

    2005-01-01

    Res Publica nõuab Reformierakonda üle läinud Tarmo Leinatammelt maksmata jäänud liikmemaksu, fraktsioon kutsub teda üles loobuma kohast Riigikogus. Erakonna pressiesindaja Riina Vändre selgitus

  12. Res Publica tahab muuta Riigikogu kuluhüvitiste süsteemi / Alari Rammo

    Index Scriptorium Estoniae

    Rammo, Alari

    2003-01-01

    Riigikogu Res Publica fraktsiooni ettepanekutest reformida Riigikogu liikmetele ette nähtud kuluhüvitiste süsteemi. Tabel: Kasutatud kuluhüvitised seisuga 15. oktoober 2003. Kommenteerib Urmo Kübar

  13. The Lublin Philosophical School: Founders, Motives, Characteristics

    Directory of Open Access Journals (Sweden)

    Mieczysław A. Krąpiec

    2015-12-01

    Full Text Available The article is focused on the Lublin Philosophical School; it explains its name, presents its founders, reveals the causes of its rise, and introduce the specific character of the School’s philosophy.It starts with stating the fact that in the proper sense, the term “Lublin Philosophical School” describes a way of cultivating realistic (classical philosophy developed in the 1950s by a group of philosophers at the Catholic University of Lublin, Poland. The Lublin Philosophical School is characterized by cognitive realism (the object of cognition is really existing being, maximalism (taking up all existentially important questions, methodological autonomy (in relation to the natural-mathematical sciences and theology, transcendentalism in its assertions (its assertions refer to all reality, methodological-epistemological unity (the same method applied in objectively cultivated philosophical disciplines, coherence (which guarantees the objective unity of the object, and objectivity (achieved by the verifiability of assertions on their own terms, which is achieved by relating them in each instance to objective evidence. The term is the name of the Polish school of realistic (classical philosophy that arose as a response to the Marxism that was imposed administratively on Polish institutions of learning, and also as a response to other philosophical currents dominant at the time such as phenomenology, existentialism, and logical positivism.

  14. Fanconi anemia founder mutation in Macedonian patients.

    Science.gov (United States)

    Madjunkova, Svetlana; Kocheva, Svetlana A; Plaseska-Karanfilska, Dijana

    2014-01-01

    Fanconi anemia (FA) is a rare autosomal recessive disorder clinically characterized by developmental abnormalities, progressive bone marrow failure (BMF) and profound cancer predisposition. Approximately 65% of all affected individuals have mutation in the FANCA (Fanconi anemia complementation group A) gene. The mutation spectrum of the FANCA gene is highly heterogeneous. FA-A is usually associated with private FANCA mutations in individual families. We describe 3 unrelated patients with FA with a similar clinical presentation: BMF, renal anomalies and café-au-lait pigmentation without major skeletal abnormality. The molecular analysis of the FANCA gene using the FA MLPA kit P031-A2/P032 FANCA, showed homozygous deletion of exon 3 in all 3 patients. Molecular analysis of the flanking regions of exon 3 precisely defined unique deletion of 2,040 bp and duplication of C (1788_3828dupC). These are the first 3 patients homozygous for deletion of FANCA exon 3 described to date. Although not related, the patients originated from the same Gypsy-like ethnic population. We conclude that c.190-256_283 + 1680del2040 dupC mutation in the FANCA gene is a founder mutation in Macedonian FA patients of Gypsy-like ethnic origin. Our finding has very strong implications for these patients in formulating diagnostic and carrier-screening strategy for BMF and FA and to enable comprehensive genetic counseling. © 2013 S. Karger AG, Basel.

  15. The Effect of Founder Family Influence on Hedging and Speculation

    DEFF Research Database (Denmark)

    Aabo, Tom; Kuhn, Jochen; Zanotti, Giovanna

    We investigate the effect of founder family influence in the form of managers, board of directors, and/or ownership on hedging and speculation in medium-sized, manufacturing firms in Denmark. On a crude measure of use / non-use of derivatives we find only a weak indication of differences between...... founder family firms and other firms in relation to their management of foreign exchange rate, interest rate, and commodity price exposures. Digging deeper into a subsample of users of foreign exchange derivatives and debt denominated in foreign currency, we find that founder family firms not only tend...

  16. Founders at work stories of startups'' early days

    CERN Document Server

    Livingston, Jessica

    2008-01-01

    Livingston presents a collection of interviews with founders of famous technology companies about what happens in the very earliest days. Includes interviews with Steve Wozniak (Apple), Max Levchin (PayPal), and others.

  17. Izbirateli razotsharovalis v respublikantsahh? / Raivo Vetik ; interv. Tatjana Opekina

    Index Scriptorium Estoniae

    Vetik, Raivo

    2004-01-01

    Rahvusvaheliste ja sotsiaaluuringute instituudi direktor vastab küsimustele, mis puudutavad hinnangut valitsusele, Res Publica kampaaniat Euroopa Parlamendi valimiste eel ja valimistulemusi Eestis, Res Publica juhte, Res Publica endise juhi Rein Taagepera artiklit "Res Publica teelahkmel", Keskerakonna juhti Edgar Savisaart

  18. Cicero and the Mixed Constitution (res publica mixta

    Directory of Open Access Journals (Sweden)

    Mitja Sadek

    2009-12-01

    Full Text Available The story of the mixed constitution is the story of the most stable and just constitution. In theory, this is a combination of at least two of the three elementary forms of government (monarchy, aristocracy and democracy, with some advantages that elementary forms may lack. It originated with the deliberation of Greek philosophers, who wanted to draw up a constitution safeguarding against the permanent variation of elementary constitutional forms and against coups d’état. For both Plato and Aristotle, the mixed constitution was, above all, the reflection of a search for balance between the two extreme forms of government, direct (Athenian democracy on the one hand and the exclusion of the people from governing on the other. The Greek theory was applied by the historian Polybius to the traditional tripartite constitution of the Roman republic. In his view, the consuls were monarchic elements, the senate an aristocratic element, and the comitia a democratic one. Cicero’s introduction of the idea of the mixed constitution in De re publica can only be understood in the light of the author’s personal situation and contemporary political circumstances. His political engagement at a time when the republic was gradually transforming into a monarchy aimed at restoring the important role of the nobility, represented by the senate. For Cicero, the mixed constitution was mainly an instrument for restoring the lost balance between the consuls, the senate, and the comitia, a last chance to save the decaying republic. The concluding part of the article addresses Alois Riklin’s recent discussion of the modern reception of the mixed constitution idea, which advances the controversial thesis that the paradigm of power division, the foundation of modern representative democracy, originates directly from the mixed constitution.

  19. Recurrent and founder mutations in the PMS2 gene.

    Science.gov (United States)

    Tomsic, J; Senter, L; Liyanarachchi, S; Clendenning, M; Vaughn, C P; Jenkins, M A; Hopper, J L; Young, J; Samowitz, W; de la Chapelle, A

    2013-03-01

    Germline mutations in PMS2 are associated with Lynch syndrome (LS), the most common known cause of hereditary colorectal cancer. Mutation detection in PMS2 has been difficult due to the presence of several pseudogenes, but a custom-designed long-range PCR strategy now allows adequate mutation detection. Many mutations are unique. However, some mutations are observed repeatedly across individuals not known to be related due to the mutation being either recurrent, arising multiple times de novo at hot spots for mutations, or of founder origin, having occurred once in an ancestor. Previously, we observed 36 distinct mutations in a sample of 61 independently ascertained Caucasian probands of mixed European background with PMS2 mutations. Eleven of these mutations were detected in more than one individual not known to be related and of these, six were detected more than twice. These six mutations accounted for 31 (51%) ostensibly unrelated probands. Here, we performed genotyping and haplotype analysis in four mutations observed in multiple probands and found two (c.137G>T and exon 10 deletion) to be founder mutations and one (c.903G>T) a probable founder. One (c.1A>G) could not be evaluated for founder mutation status. We discuss possible explanations for the frequent occurrence of founder mutations in PMS2. © 2012 John Wiley & Sons A/S.

  20. Founder Family Influence and Foreign Exchange Risk Management

    DEFF Research Database (Denmark)

    Aabo, Tom; Kuhn, Jochen; Zanotti, Giovanni

    2011-01-01

    Purpose    The purpose of this study is to explore the influence of founder families in medium-sized, manufacturing firms and to investigate the impact of such influence on risk management - more specifically foreign exchange hedging and speculation. Design/methodology/approach This empirical study...... in the management team, are members of the board of directors, and/or are shareholders of the firm. We find no difference between such founder family firms and other firms in terms of the use / non-use decision related to foreign exchange derivatives but a marked difference in terms of the extent decision. Thus...... in medium-sized firms (as opposed to large, listed firms in most other studies) and adds to the sparse literature on the impact of founder family influence on risk management.  ...

  1. Res Publica soovib riigikogulaste kuluhüvitiste korra muutmist / Siim-Valmar Kiisler ; interv. Kalle Muuli

    Index Scriptorium Estoniae

    Kiisler, Siim, 1965-

    2003-01-01

    Res Publica saadikud teevad Riigikogu juhatusele ettepaneku muuta kuluhüvitiste korda, teatas intervjuus Res Publica saadikurühma esimees Siim-Valmar Kiisler. Kommenteerivad: Jaanus Männik, Toomas Varek. Vt. samas: Riigikogu liikmete vastuseid küsimustele tööga seotud kulude kohta: Robert Lepikson, Reet Roos, Janno Reiljan

  2. Utilization of founder lines for improved Citrus biotechnology via RMCE

    Science.gov (United States)

    On October 1st 2011 the CRB chose to fund a unique research project, the development of citrus cultivars specifically for genetic engineering (GE). The objective of this research was to develop GE citrus ‘Founder Lines’ containing DNA sequences that will allow the precise insertion of genes for de...

  3. Founders of share companies under the Ethiopian share company law

    African Journals Online (AJOL)

    This article explores the Commercial Code and other laws of Ethiopia regarding founders – who they are, liabilities and benefits - who are also called 'promoters' by many other company laws. To some extent, it also looks into the business practice based on documents like memorandum of associations, articles of ...

  4. What founders in developing countries learn about organizing microenterprise growth

    DEFF Research Database (Denmark)

    Pötz, Katharina Anna; Hjortsø, Carsten Nico Portefée

    organizational failure. In this regard, we find that only those founders that rapidly make sense of ineffective processes, gain management knowledge from different sources, and devote time and energy to managerial tasks, manage to sustain organizational growth by learning to make ‘fixes’ for internal problems...

  5. Res Publica murrab läbi / Urmo Kübar

    Index Scriptorium Estoniae

    Kübar, Urmo, 1978-

    2004-01-01

    Ilmunud ka: Võta Võim : na russkom jazõke, 28. apr. 2004, lk. 1. 18. aprillil 2004 Tallinnas toimunud Res Publica valimiskonverentsist, kus kinnitati programm ja kandidaadid Euroopa Parlamendi valimisteks. Esinesid Urmas Reinsalu ja Juhan Parts. Vt. samas: Kust tuli 'Murrame läbi'?

  6. Res Publica alustas Tallinnas koostööd Keskerakonnaga / Siim Männik

    Index Scriptorium Estoniae

    Männik, Siim

    2005-01-01

    Ilmunud ka: Vabariik (venek.) 18. apr. lk. 2. Koalitsioonivahetusest Tallinnas. Linnavolikogu Res Publica fraktsiooni esimehe Andres Korgi, linnapea Tõnis Paltsi nõuniku Jaano Martin Otsa kommentaare. Tallinna linnapea hinnangul on sügisel koalitsiooni asudes seatud eesmärgid praeguseks peaaegu saavutatud

  7. Res Publica nõuab rea võimulubaduste täitmist / Rasmus Kagge

    Index Scriptorium Estoniae

    Kagge, Rasmus, 1977-

    2005-01-01

    Res Publica lubas koalitsioonipartneritele mitte minna koalitsioonileppe kallale, kui nad toetavad toppama jäänud lubaduste täitmist - haridusreformi, presidendi otsevalimiste seadustamist, riigikontrollile ka omavalitsuste kontrollimiseks õiguse andmist ja lapsevanema tulumaksuvaba miinimumi kahekordistamist alates pere teisest lapsest. Lisa: Võimuliitlaste soovid

  8. Res Publica nõuab veel üht abilinnapea kohta / Urmas Seaver

    Index Scriptorium Estoniae

    Seaver, Urmas, 1973-

    2005-01-01

    Tallinna linnapea Tõnis Palts on seisukohal, et Reformierakond surus koalitsiooni moodustamisel Res Publicale peale ebaõiglase vastutusvaldkondade jaotuse. Res Publica peasekretär Ott Lumi ei välista võimuliidu loomist Keskerakonnaga, kui Reformierakond järeleandmisi ei tee. ERL tegi ettepaneku kokku kutsuda erakondade ümarlaud. Vt. samas intervjuud Ott Lumiga

  9. A common Greenlandic Inuit BRCA1 RING domain founder mutation

    DEFF Research Database (Denmark)

    Hansen, T.v.O.; Ejlertsen, B.; Albrechtsen, Anders

    2009-01-01

    of the families had members with ovarian cancer, suggesting that the RING domain may be an ovarian cancer hotspot. By SNP array analysis, we find that all 13 families share a 4.5 Mb genomic fragment containing the BRCA1 gene, showing that the mutation originates from a founder. Finally, analysis of 1152 Inuit......, representing almost ~2% of the total Greenlandic Inuit population, showed that the frequency of the mutation was 1.0%. We conclude that the BRCA1 nucleotide 234 T > G is a common Greenlandic Inuit founder mutation. The relative high frequency in the general population, together with the ease of screening...... and possibility to reduce mortality in gene carriers, may warrant screening of the Greenlandic Inuit population. Provided screening is efficient, about 5% of breast- and 13% of ovarian cancers, respectively, may be prevented Udgivelsesdato: 2009/5...

  10. ABOUT THE FOUNDERS OF LEGAL SOCIOLOGY AND THEIR IDEAS

    Directory of Open Access Journals (Sweden)

    MIRELA CRISTIANA NILĂ STRATONE

    2013-05-01

    Full Text Available The main founders of the juridical sociology are considered to be Eugen Ehrlich, Max Weber, Theodor Geiger and Georges Gurvitch, The researches of juridical sociology from Romania are demonstrating the existence of a real tradition in this domain at a national standard. Some roumanian explores of formation jurists have practicated in the cognitive demarche a sociologycal abordation about the law, what have been fatal conduced to the fixing of the base of the juridical sociology in Romania.

  11. Isamaa ja Res Publica liit tõotab neile kõrget kohta edetabelis / Rasmus Kagge

    Index Scriptorium Estoniae

    Kagge, Rasmus, 1977-

    2006-01-01

    Ilmunud ka: Postimees : na russkom jazõke 10. apr. lk. 7. TNS Emori märtsikuu erakondade populaarsusuuringu tulemused näitavad, et Res Publicaga liituda otsustanud Isamaaliit on tõusnud poliitedetabelis kolmandale kohale. Res Publica reiting on endiselt madal, edetabelit juhib Keskerakond. Diagrammid: Isamaaliit kogub toetajaid tõusvas tempos. Vt. samas: Ühendpartei Eesti Eest! otsib endale uut nime

  12. MSR Founders Narrative and Content Analysis of Scholarly Papers

    DEFF Research Database (Denmark)

    Tackney, Charles T.; Chappell, Stacie F.; Sato, Toyoko

    2017-01-01

    This is a founders’ narrative and research paper content analysis of the first 15 years of the Management Spirituality and Religion Interest Group (MSR) of the Academy of Management. Based on archival data and founder interviews, our inquiry recounts how the early collaborators established......: a corpus epitomizing MSR research and practice. The combined study is a benchmark of founding and institutionalization for current and potential MSR members. By tracing the research trends MSR has taken in light of the founding aspirations, we illuminate the distinctive values, tensions, and meanings...

  13. 50 years of Dutch immunology--founders, institutions, highlights.

    Science.gov (United States)

    Gmelig-Meyling, Frits H J; Meyaard, Linde; Mebius, Reina E

    2014-12-01

    At the occasion of the 50th anniversary of the Dutch Society for Immunology (DSI, de Nederlandse Vereniging voor Immunologie), this contribution deals with some highlights of 50 years of Immunology in the Netherlands. It narrates about the founders and first board members of the DSI, their institutes, progeny and patrimony, describes major centers of immunological activities, mentions key persons in the field, and touches upon some events dear to the Society and its members. Copyright © 2014 Elsevier B.V. All rights reserved.

  14. The advantage of experienced start-up founders in venture capital acquisition: evidence from serial entrepreneurs

    OpenAIRE

    Zhang, Junfu

    2007-01-01

    Existing literature suggests that entrepreneurs with prior firm-founding experience have more skills and social connections than novice entrepreneurs. Such skills and social connections could give experienced founders some advantage in the process of raising venture capital. This paper uses a large database of venture-backed companies and their founders to examine experienced founders' access to venture capital. Compared to novice entrepreneurs, entrepreneurs with venture-backed founding expe...

  15. Estado da Arte da Publicação Nacional e Internacional sobre Neuromarketing e Neuroeconomia

    OpenAIRE

    Caissa Veloso e Sousa; José Edson Lara; Erich Vale e Sousa; Jefferson Rodrigues Pereira

    2016-01-01

    Nas últimas três décadas os estudos envolvendo as áreas de Neurociência e Engenharia biomédica e que convergem para a possibilidade de mapeamento e avaliação do cérebro in vivo apresentaram desenvolvimento significativo, possibilitando a emersão, nas ciências sociais, dos campos de pesquisa chamados de Neuromarketing e Neuroeconomia. No presente trabalho foram analisadas as publicações existentes sobre o t...

  16. Founder takes all: density-dependent processes structure biodiversity.

    Science.gov (United States)

    Waters, Jonathan M; Fraser, Ceridwen I; Hewitt, Godfrey M

    2013-02-01

    Density-dependent processes play a key role in the spatial structuring of biodiversity. Specifically, interrelated demographic processes, such as gene surfing, high-density blocking, and competitive exclusion, can generate striking geographic contrasts in the distributions of genes and species. Here, we propose that well-studied evolutionary and ecological biogeographic patterns of postglacial recolonization, progressive island colonization, microbial sectoring, and even the 'Out of Africa' pattern of human expansion, are fundamentally similar, underpinned by a 'founder takes all' density-dependent principle. Additionally, we hypothesize that older historic constraints of density-dependent processes are seen today in the dramatic biogeographic shifts that occur in response to human-mediated extinction events, whereby surviving lineages rapidly expand their ranges to replace extinct sister taxa. Copyright © 2012 Elsevier Ltd. All rights reserved.

  17. Founder Control, Ownership Structure and Firm Value: Evidence from Entrepreneurial Listed Firms in China

    Directory of Open Access Journals (Sweden)

    Lijun Xia

    2008-06-01

    Full Text Available In emerging markets, the deviation between the ultimate controlling shareholders' voting rights and their cash flow rights (hereafter “DVC” in the listed firms is quite prevalent. DVC could be introduced due to the ultimate controlling shareholders' opportunistic incentives, as well as by their incentives to improve firm efficiency. This study uses 229 listed firms ultimately controlled by individuals or families (hereafter “entrepreneurial firms” for 2004 in China, to investigate the effect of DVC on firm value and to determine whether it is different between founder and non-founder controlled firms. We find that DVC has a positive effect on firm value for founder controlled firms. This result implies that investors believe that their interests are better protected by founder controlled firms than by non-founder controlled firms.

  18. Identification of kin structure among Guam rail founders: a comparison of pedigrees and DNA profiles

    Science.gov (United States)

    Haig, Susan M.; Ballou, J.D.; Casna, N.J.

    1994-01-01

    Kin structure among founders can have a significant effect on subsequent population structure. Here we use the correlation between DNA profile similarity and relatedness calculated from pedigrees to test hypotheses regarding kin structure among founders to the captive Guam rail (Rallus owstoni) population. Five different pedigrees were generated under the following hypotheses: (i) founders are unrelated; (ii) founders are unrelated except for same-nest chicks; (iii) founders from the same major site are siblings; (iv) founders from the same local site are siblings; and (v) founders are related as defined by a UPGMA cluster analysis of DNA similarity data. Relatedness values from pedigrees 1, 2 and 5 had the highest correlation with DNA similarity but the correlation between relatedness and similarity were not significantly different among pedigrees. Pedigree 5 resulted in the highest correlation overall when using only relatedness values that changed as a result of different founder hypotheses. Thus, founders were assigned relatedness based on pedigree 5 because it had the highest correlations with DNA similarity, was the most conservative approach, and incorporated all field data. The analyses indicated that estimating relatedness using DNA profiles remains problematic, therefore we compared mean kinship, a measure of genetic importance, with mean DNA profile similarity to determine if genetic importance among individuals could be determined via use of DNA profiles alone. The significant correlation suggests this method may provide more information about population structure than was previously thought. Thus, DNA profiles can provide a reasonable explanation for founder relatedness and mean DNA profile similarity may be helpful in determining relative genetic importance of individuals when detailed pedigrees are absent.

  19. Editorial: Integridade na pesquisa e ética na publicação

    OpenAIRE

    Shinkai, Rosemary Sadami Arai

    2011-01-01

    As exigências de produção intelectual com base nas publicações científicas constituem mecanismos de pressão sobre pesquisadores, docentes e discentes de programas de pós-graduação, uma vez que os indicadores de qualidade acadêmica estão atualmente atrelados à produção bibliográfica tanto no Brasil quanto no exterior. Nesse contexto, tornam-se cada vez mais necessárias políticas editoriais definidas para que o periódico científico exerça seu papel de orientar a comunidade científica sobre boas...

  20. O virtual e os novos paradigmas da publicação acadêmica

    Directory of Open Access Journals (Sweden)

    Renato Nunes Bittencourt

    2012-02-01

    Full Text Available O presente artigo analisa as vantagens técnicas das publicações acadêmicas realizadas pelo suporte virtual, em decorrência da dinamicidade das interações intelectuais próprias da dimensão da Internet. Através do enfoque teórico de Pierre Lévy, um dos principais filósofos da dita “Cibercultura”, apresentamos as mudanças de perspectivas epistemológicas operadas pela difusão planetária da Internet e de que maneira tal transformação influenciou no processo de editoração dos periódicos acadêmicos, envolvendo de forma mais precisa a participação plena da comunidade intelectual em torno do processo de realização do veículo de difusão de conhecimento.

  1. Venelastest Res Publica toetajad Ida-Virus võivad uuele parteile selja pöörata / Erik Kalda

    Index Scriptorium Estoniae

    Kalda, Erik, 1969-

    2006-01-01

    Ilmunud ka: Severnoje Poberezhje 6. apr. lk. 3, Narvskaja Nedelja 8. apr. lk. 2. Suur osa Ida-Virumaal elavatest Res Publica liikmetest ning toetajatest ei poolda erakonna ühinemist Isamaaliiduga, sest paljude venelaste meelest on Isamaaliit nende huve eirav partei

  2. Plágio e publicação científica

    Directory of Open Access Journals (Sweden)

    André Luís Gemal

    2015-05-01

    Full Text Available Nos últimos anos, a palavra ética tem estado em evidência no país, usualmente referida a sua ausência. Neste cenário, no qual sobram palavras e faltam atitudes, refletir, debater e concretizar ações sobre este tema na publicação científica tornam-se imprescindíveis. O acesso aberto e a democratização do conhecimento e, principalmente, da informa-ção, têm permitido atualmente uma possibilidade fabulosa de avanços na formação de pesquisadores e cidadãos.Neste contexto, a cultura do plágio tem maiores condições de se disseminar e de se tornar socialmente aceita. Isto faz com que instituições e editores de revistas científicas sejam colocados em situações que exigem atitudes imediatas e coerentes com os princípios éti-cos do campo da ciência. Em uma rápida busca no Google do termo “plágio em publicação científica”, encontramos cerca de 400 mil resultados, o que evidencia os danos e riscos que dizem respeito a todos nós: editores, pesquisadores, alunos, gestores de instituições de pesquisa — corresponsáveis pela acuidade da informação — e leitores.

  3. Citibikes de Colombia. La bicicleta publica: sistema alternativo de transporte para Santafe de Bogota

    Directory of Open Access Journals (Sweden)

    Javier Enrique Ramos

    2000-12-01

    Full Text Available EI objetivo del presente artículo es presentar una nueva propuesta en materia de transporte urbano, teniendo en cuenta el cada vez más restringido uso del automóvil particular y la ineficiencia de los actuales médicos de transporte público. En la primera parte del trabajo se presenta un panorama general de la importancia de los sistemas de transporte en las ciudades y cómo afectan la vida de sus habitantes. También se muestra la situación actual del transite en Bogotá y la necesidad de implantar sistemas alternativos de transporte. En la segunda parte, se propone el diseño de un sistema en línea de alquiler de bicicletas denominado Bicicleta Publica, que sea parte integral del Sistema integrado de transporte para Santafé de Bogotá. Para cumplir con este propósito se presentan los lineamientos generales mediante un plan de negocios, que conduzca a la creación de una empresa que administre el sistema y los servicios conexos. EI plan de negocios pretende cubrir la mayor parte de la ciudad, ubicando estaciones de bicicleta publica en diferentes lugares, principalmente en las áreas de influencia de las universidades, parques, centros comerciales y, en un futuro, en las estaciones de Transmilenio y el Metro. Esto le brinda al usuario la posibilidad de tomar una bicicleta en un punto determinado y retornarla en otra estación diferente a donde la alquiló inicialmente. Las ventajas de este mecanismo son apreciables, ya que no representa complicación alguna para el usuario debido a que puede usar la bicicleta el tiempo deseado sin preocuparse por aspectos tales como el estacionamiento, el clima o las diferentes actividades, para lo cual la bicicleta propia sería un completo inconveniente.

  4. Ludwig Edinger (1855-1918): founder of modern neuroanatomy.

    Science.gov (United States)

    Prithishkumar, Ivan James

    2012-03-01

    Ludwig Edinger, a German neurologist is considered as one of the founders of modern neuroanatomy. He was conferred the degree of Doctor of Medicine at the University of Strassburg. His observation of small living organisms under a microscope at an early age led him to study medicine. Edinger had many discoveries to his credit. He was the first to describe the ventral and dorsal spinocerebellar tracts, to distinguish between paleo-encephalon and neo-encephalon, and between paleo-cerebellum and neo-cerebellum. He coined the terms "gnosis" and "praxis," which were later adopted in psychological descriptions of agnosia and apraxia. He identified the Edinger-Westphal nucleus in 1885 and was the first to describe the syndrome of thalamic pain. Edinger worked with renowned clinicians and published a large number of papers. He founded the Neurological Institute at the Goethe University in Frankfurt, which is the oldest neurological Institute in Germany. Edinger was a rare combination of a profound scientist, a brilliant teacher, a fine artist, and a noted hypnotist. While at the height of his career, he underwent a surgery and died a few hours later. It was his last will that his brain should be dissected in his own institute. It showed extraordinarily well-developed occipital lobes as well as other unusual features. Copyright © 2011 Wiley-Liss, Inc.

  5. Cancer risks and immunohistochemical profiles linked to the Danish MLH1 Lynch syndrome founder mutation

    DEFF Research Database (Denmark)

    Therkildsen, Christina; Isinger-Ekstrand, Anna; Ladelund, Steen

    2012-01-01

    Founder mutations with a large impact in distinct populations have been described in Lynch syndrome. In Denmark, the MLH1 c.1667+2_1667_+8TAAATCAdelinsATTT mutation accounts for 25 % of the MLH1 mutant families. We used the national Danish hereditary nonpolyposis colorectal cancer register...... to estimate the cumulative lifetime risks for Lynch syndrome-associated cancer in 16 founder mutation families with comparison to 47 other MLH1 mutant families. The founder mutation conferred comparable risks for colorectal cancer (relative risks, RR, of 0.99 for males and 0.79 for females) and lower risks...... in 68 % with extensive inter-tumor variability despite the same underlying germline mutation. In conclusion, the Danish MLH1 founder mutation that accounts for a significant proportion of Lynch syndrome and is associated with a lower risk for extracolonic cancers....

  6. Founder effects and genetic population structure of brown trout (Salmo trutta) in a Danish river system

    DEFF Research Database (Denmark)

    Hansen, Michael Møller; Mensberg, Karen-Lise Dons

    1996-01-01

    The influence of founder effects on the genetic population structure of brown trout (Salmo trutta) was studied in a small Danish river system. Samples of trout from seven locations were analysed by allozyme electrophoresis and mitochondrial DNA restriction fragment length polymorphism analysis....... For comparison, allozyme data from other Danish trout populations and mtDNA data from two hatchery strains were included. Genetic differentiation among populations was found to be small but significant. Pairwise tests for homogeneity of allele and haplotype frequencies between samples showed that significance...... simulations of the influence of founder effects on mitochondrial DNA differentiation and variability showed that the observed divergence could be due either to natural founder effects or to a genetic contribution by hatchery trout. However, the allozyme results pointed towards natural founder effects...

  7. The Slavic NBN Founder Mutation: A Role for Reproductive Fitness?

    Directory of Open Access Journals (Sweden)

    Eva Seemanova

    Full Text Available The vast majority of patients with Nijmegen Breakage Syndrome (NBS are of Slavic origin and carry a deleterious deletion (c.657del5; rs587776650 in the NBN gene on chromosome 8q21. This mutation is essentially confined to Slavic populations and may thus be considered a Slavic founder mutation. Notably, not a single parenthood of a homozygous c.657del5 carrier has been reported to date, while heterozygous carriers do reproduce but have an increased cancer risk. These observations seem to conflict with the considerable carrier frequency of c.657del5 of 0.5% to 1% as observed in different Slavic populations because deleterious mutations would be eliminated quite rapidly by purifying selection. Therefore, we propose that heterozygous c.657del5 carriers have increased reproductive success, i.e., that the mutation confers heterozygote advantage. In fact, in our cohort study of the reproductive history of 24 NBS pedigrees from the Czech Republic, we observed that female carriers gave birth to more children on average than female non-carriers, while no such reproductive differences were observed for males. We also estimate that c.657del5 likely occurred less than 300 generations ago, thus supporting the view that the original mutation predated the historic split and subsequent spread of the 'Slavic people'. We surmise that the higher fertility of female c.657del5 carriers reflects a lower miscarriage rate in these women, thereby reflecting the role of the NBN gene product, nibrin, in the repair of DNA double strand breaks and their processing in immune gene rearrangements, telomere maintenance, and meiotic recombination, akin to the previously described role of the DNA repair genes BRCA1 and BRCA2.

  8. N.A. Bernstein, the founder of modern biomechanics

    Directory of Open Access Journals (Sweden)

    Vazha M. Devishvili

    2015-12-01

    Full Text Available The paper deals with three major periods of scientific work of Nikolai Alexandrovich Bernstein, the outstanding Russian scientist, the founder the motor activity theory of human and animal. In 2016 is the 120th anniversary of Bernstein´s birth. The first period of his scientific activity, from 1922 when Bernstein started his research at the Central Institute of Labour Protection until the middle of the 30s of the 20th century. By this time, he formulated and published the basic principles and ideas of the annular motion control and sensor correction movements of varying complexity and various performance. The second period ends with the fundamental scientific work «On the Construction of Movements» awarded by the USSR State Prize in 1948. The book sums up Bernstein´s more than twenty years of research in the field of biomechanics and physiology of movement. The paper briefly describes the main assumptions of the three chapters of the book. The first chapter «Movements» reveals the evolutionary ideas about the origin of motor function and shaped the principle of the equation of building movements. The second chapter describes five levels with different functionality in varying degrees involved in the implementation of motor actions. The third chapter of the «Development and Decay» deals with the general laws of occurrence and levels of building movements being signs of confirming the level structure of motion in pathology and standards. In 1950-60-ies of the 20th century Bernstein greatly expanded representation of the functional content and neural substrate levels of building movements, detailed the stages and phases of shaping and improvement of motor skills. The author shows the importance of scientific achievements of N.A. Bernstein for modern research in the psychophysiology of movements.

  9. Business strategy versus human resources strategy: the influence of the founder in small business

    Directory of Open Access Journals (Sweden)

    Juliana Popp Barbosa Lima

    2016-12-01

    Full Text Available Small and medium-sized businesses with familiar characteristics have been object of study in recent years, especially about the succession process, considering it is extremely critical to the longevity and sustainability of the organization. However, the figure of the founder and its impact in these organizations is less explored in academia. Thus, this article seeks to fill this gap, addressing the influences of the founder in the dissemination of business and HR strategies in these companies. Through a qualitative and quantitative research, there was a case of a single organization study seeking further analysis of the subject. The collection of qualitative data was given through an interview with semi-structured interview with the founder of the organization and the qualitative by applying a questionnaire with closed questions with officials of various hierarchical levels. It was observed that the personal values and the founding principles are permeated the organization, reflected in the mission and values of the company, as well as how the founder treats topics such as business strategy and the role of people management are decisive for inclusion and driving these topics within family-based organizations. The purpose of analyzing the spread of business strategies and human resources of the Founder has been reached. It was found that, in general, strategies portray the way of the Founder, however, the spread of these to the various hierarchical levels, demonstrates a more complex, as in the HRM.

  10. Estado da Arte da Publicação Nacional e Internacional sobre Neuromarketing e Neuroeconomia

    Directory of Open Access Journals (Sweden)

    Caissa Veloso e Sousa

    2016-03-01

    Full Text Available Nas últimas três décadas os estudos envolvendo as áreas de Neurociência e Engenharia biomédica e que convergem para a possibilidade de mapeamento e avaliação do cérebro in vivo apresentaram desenvolvimento significativo, possibilitando a emersão, nas ciências sociais, dos campos de pesquisa chamados de Neuromarketing e Neuroeconomia. No presente trabalho foram analisadas as publicações existentes sobre o tema em bases nacionais e internacionais. Pesquisaram-se as seguintes bases de dados: Associação Nacional de Pós-Graduação e Pesquisa em Administração (ANPAD; Ebscohost Research Databases (EBSCO, Google Acadêmico, Portal de Periódicos Capes, PubMed (US National Library of Medicine National Institutes of Health; Scientific Eletronic Library Online (SCIELO, Scientific Periodicals Eletronic Library (SPELL. A predominância de trabalhos teóricos reflete uma possível dificuldade de se realizar pesquisas empíricas, o que pode estar relacionado tanto ao custo financeiro efetivo dessas pesquisas, quanto ao acesso aos canais integrativos de pesquisa, que dependem de uma equipe transdisciplinar.

  11. Ken-Marti Vaher : Paremjõudude ühinemine on Res Publica esmane ülesanne / Ken-Marti Vaher ; interv. Tanel Mazur

    Index Scriptorium Estoniae

    Vaher, Ken-Marti, 1974-

    2004-01-01

    Ilmunud ka: Narvskaja Gazeta, 6. nov. 2004, lk. 2. Ida-Virumaad külastanud justiitsminister Ken-Marti Vaher Rakveres ja Narvas arutatust, praeguse võimupartei Res Publica seisukohtadest, tulevikuplaanidest

  12. The workforce composition of young firms and product innovation - complementarities in the skills of founders and their early employees

    OpenAIRE

    Müller, Bettina; Murmann, Martin

    2016-01-01

    We investigate the extent to which complementarities between technical and business skills of founders and employees matter for the generation of market novelties by new ventures. Using data about German start-ups, we find that there are no complementarities between technical and business skills within the group of founders, but that there are significant complementarities between technically trained founders and employees who have business skills. This suggests that the innovation potenti...

  13. Characterization of a mutation commonly associated with persistent stuttering: evidence for a founder mutation

    Science.gov (United States)

    Fedyna, Alison; Drayna, Dennis; Kang, Changsoo

    2010-01-01

    Stuttering is a disorder which affects the fluency of speech. It has been shown to have high heritability, and has recently been linked to mutations in the GNPTAB gene. One such mutation, Glu1200Lys, has been repeatedly observed in unrelated families and individual cases. Eight unrelated individuals carrying this mutation were analyzed in an effort to distinguish whether these arise from repeated mutation at the same site, or whether they represent a founder mutation with a single origin. Results show that all 12 chromosomes carrying this mutation share a common haplotype in this region, indicating it is a founder mutation. Further analysis estimated the age of this allele to be ~572 generations. Construction of a cladogram tracing the mutation through our study sample also supports the founder mutation hypothesis. PMID:20944643

  14. Do VCs use inside rounds to dilute founders? Some evidence from Silicon Valley

    OpenAIRE

    Fried, Jesse M.; Broughman, Brian J.

    2012-01-01

    In the bank-borrower setting, a firm’s existing lender may exploit its positional advantage to extract rents from the firm in subsequent financings. Analogously, a startup’s existing venture capital investors (VCs) may dilute the founder through a follow-on financing from these same VCs (an “inside” round) at an artificially low valuation. Using a hand-collected dataset of Silicon Valley startup firms, we find little evidence that VCs use inside rounds to dilute founders. Instead, our finding...

  15. The long-lasting customs (longa consuetudine and the public interests (utilitas publica

    Directory of Open Access Journals (Sweden)

    Sič Magdolna

    2011-01-01

    Full Text Available In the process of creating the Roman Empire as well as thereafter during the struggle for its existence, the following question emerges: to which extent should be the acceding nations allowed to practice their deeply embedded customary rules? This question is important also nowadays in times of creation of the European Union and its unified legal system. In terms of the use of customs Rome has been changing its attitude depending on important changes in the society. In times of a rise, during the period of Republic, Rome was deciding on whether it will allow or forbid the acceding nations to continue living by their own customs and religious rules. Later, when the roman citizenship has been given to all inhabitants of the Empire by Caracalla's Edict (in the 212. year, a liberal approach has been taken. In the constitution of Alexander Sever, as well as in the fragments of the classical lawyers one can read about the obligation of the judge to take into account the customs. However, when the Empire got into a serious crisis and barbarian people came onto the roman land, a general boundary has been set towards the use of longlasting customs: these customs could be used, and potentially even have the force of a law, as long as they did not jeopardize the interests of the Empire (utilitas publica. The analyzed rules on the question can the potential future heirs dispose with the future heritage (the goods of a living person - bonis viventis in the classical, post-classical and Justinian's law, points onto the fact that the postclassical cutomary rules, that were not in conflict with the interests of the Empire, contributed even to the changes of the rules of the classical roman law. In the taken example, the classical rule according to which the disposal with future heritage is null and void, is modified under the influence of a German custom in a way that, property division and disposal with the divided property by future heirs was allowed

  16. A novel FKRP-related muscular dystrophy founder mutation in South ...

    African Journals Online (AJOL)

    porphyria variegata, familial hypercholesterolaemia, Gaucher's dis- ease and autosomal recessive polycystic kidney disease.[7-11]. FKRP founder mutations have been described in a number of populations around the world, for example the c.826C>A. (p.Leu276Ile) FKRP mutation in 20 LGMD German patients[12].

  17. Evaluating the importance of metamorphism in the foundering of continental crust.

    Science.gov (United States)

    Chapman, Timothy; Clarke, Geoffrey L; Piazolo, Sandra; Daczko, Nathan R

    2017-10-12

    The metamorphic conditions and mechanisms required to induce foundering in deep arc crust are assessed using an example of representative lower crust in SW New Zealand. Composite plutons of Cretaceous monzodiorite and gabbro were emplaced at ~1.2 and 1.8 GPa are parts of the Western Fiordland Orthogneiss (WFO); examples of the plutons are tectonically juxtaposed along a structure that excised ~25 km of crust. The 1.8 GPa Breaksea Orthogneiss includes suitably dense minor components (e.g. eclogite) capable of foundering at peak conditions. As the eclogite facies boundary has a positive dP/dT, cooling from supra-solidus conditions (T > 950 ºC) at high-P should be accompanied by omphacite and garnet growth. However, a high monzodioritic proportion and inefficient metamorphism in the Breaksea Orthogneiss resulted in its positive buoyancy and preservation. Metamorphic inefficiency and compositional relationships in the 1.2 GPa Malaspina Pluton meant it was never likely to have developed densities sufficiently high to founder. These relationships suggest that the deep arc crust must have primarily involved significant igneous accumulation of garnet-clinopyroxene (in proportions >75%). Crustal dismemberment with or without the development of extensional shear zones is proposed to have induced foundering of excised cumulate material at P > 1.2 GPa.

  18. The impact of founder events on chromosomal variability in multiply mating species

    DEFF Research Database (Denmark)

    Pool, John E; Nielsen, Rasmus

    2008-01-01

    size reductions and recent bottlenecks leading to decreased X/A diversity ratios. Here we use theory and simulation to investigate a separate demographic effect-that of founder events involving multiply mated females-and find that it leads to much stronger reductions in X/A diversity ratios than...

  19. How lead founder personality affects new venture performance : the mediating role of team conflict

    NARCIS (Netherlands)

    Jong, de A.; Song, M.; Song, L.Z.

    2013-01-01

    This empirical study of 323 new ventures examines how task and relationship conflict in the founding top management team mediates the effect of lead founder personality on new venture performance. The results reveal that (1) openness and agreeableness increase task conflict, whereas

  20. How Lead Founder Personality Affects New Venture Performance: The Mediating Role of Team Conflict

    NARCIS (Netherlands)

    de Jong, Ad; Song, Michael; Song, Lisa Z.

    2013-01-01

    This empirical study of 323 new ventures examines how task and relationship conflict in the founding top management team mediates the effect of lead founder personality on new venture performance. The results reveal that (1) openness and agreeableness increase task conflict, whereas

  1. Effects of founder population size on the performance of Orius laevigatus (Hemiptera: Anthocoridae) colonies

    NARCIS (Netherlands)

    Castañe, C.; Bueno, V.H.P.; Carvalho, L.M.; Lenteren, van J.C.

    2014-01-01

    Orius laevigatus (Hemiptera: Anthocoridae) is a key predator of thrips and is mass reared in large numbers for use in biological control. The aim of this study was to evaluate the effect of founder population size on the biological and behavioral performance of O. laevigatus over time. Laboratory

  2. Análise das publicações dos enfermeiros assistenciais em periódicos nacionais

    Directory of Open Access Journals (Sweden)

    Ana Maria Dyniewicz

    2010-12-01

    Full Text Available Esta pesquisa identificou a participação de enfermeiras assistenciais em publicações. Foi realizada revisão bibliográfica em três periódicos nacionais entre 2000 a 2007, somando 1.918 artigos. A enfermeira assistencial esteve como autora ou co-autora em 162 artigos (8.5%; em 75 publicações não houve identificação de sua titulação. Os doutores foram os que mais publicaram com enfermeiras e as áreas com maior número de artigos: educação em saúde e enfermagem, saúde do adulto e idoso. Concluiu-se que as enfermeiras têm maior facilidade em publicar em grupos de pesquisas e que ao assumirem a prática, mesmo depois de pós-graduação, não mantêm a produção científica. Há necessidade de maior empenho de toda a categoria profissional para ampliar essa participação em periódicos.

  3. O marketing direto como canal de marketing no setor de publicações periódicas (revistas e jornais) em São Paulo

    OpenAIRE

    Kato, Heitor Takashi

    2010-01-01

    Trata da utilização do marketing direto como canal de marketing para as empresas editoras de publicações periódicas em São Paulo. Conceitua o marketing direto e descreve suas variantes. Faz um breve histórico das publicações periódicas e do papel das assinaturas desde sua origem. Utilizando-se do esquema teórico de Aspinwall e do estudo do caso de empresas de publicações periódicas em São Paulo, analisa o potencial da utilização do marketing direto como canal de marketing para outras categori...

  4. A publicação de periódicos científicos digitais

    Directory of Open Access Journals (Sweden)

    Rosângela Schwarz Rodrigues

    2011-05-01

    Full Text Available http://dx.doi.org/10.5007/1518-2924.2011v16n31pi Os periódicos científicos aumentam de importância na medida em que Ciência e Tecnologia são entendidas como essenciais para o bem estar da população e o desenvolvimento sustentável dos países. Como responsáveis pela certificação e divulgação dos resultados das pesquisas em todas as áreas, os periódicos são os canais de comunicação prioritários da ciência. Em função da relevância crescente da publicação científica em todas as áreas do conhecimento, os periódicos são pressionados cada vez mais a elevar seus padrões de qualidade, com o objetivo de atrair mais e melhores artigos, o que implica em maior número de leitores e citações. As instituições de fomento e avaliação da ciência consideram a publicação como elemento final do ciclo da pesquisa, e indicador quantitativo e qualitativo para a construção de confiabilidade e prestígio para os indivíduos, grupos e instituições que formam a rede. A Ciência da Informação é área que tem no estudo da Comunicação Científica uma de suas principais vertentes e esta condição exige que tenhamos excelentes e inovadores periódicos. A Encontros Bibli: revista de biblioteconomia e ciência da informação é pioneira, sendo a primeira revista exclusivamente digital da Ciência da Informação no Brasil. Em 1996, no dia 09 de maio, a revista Encontros Bibli, por iniciativa do então Departamento de Biblioteconomia e Documentação, atual Departamento de Ciência da Informação da Universidade Federal de Santa Catarina (UFSC, ingressava na Web, a partir de seu primeiro número, utilizando a ferramenta HTML e mais tarde agregando outros recursos de edição, como a edição final dos textos em PDF. Desde então, tem se mantido neste ambiente, com periodicidade semestral e edições especiais. No ano 2003, a Encontros Bibli foi incluída na Rede de Revistas Cientificas da América Latina, Caribe, Espanha e

  5. A publicação de periódicos científicos digitais

    Directory of Open Access Journals (Sweden)

    Rosângela Schwarz Rodrigues

    2011-05-01

    Full Text Available Os periódicos científicos aumentam de importância na medida em que Ciência e Tecnologia são entendidas como essenciais para o bem estar da população e o desenvolvimento sustentável dos países. Como responsáveis pela certificação e divulgação dos resultados das pesquisas em todas as áreas, os periódicos são os canais de comunicação prioritários da ciência.Em função da relevância crescente da publicação científica em todas as áreas do conhecimento, os periódicos são pressionados cada vez mais a elevar seus padrões de qualidade, com o objetivo de atrair mais e melhores artigos, o que implica em maior número de leitores e citações. As instituições de fomento e avaliação da ciência consideram a publicação como elemento final do ciclo da pesquisa, e indicador quantitativo e qualitativo para a construção de confiabilidade e prestígio para os indivíduos, grupos e instituições que formam a rede.A Ciência da Informação é área que tem no estudo da Comunicação Científica uma de suas principais vertentes e esta condição exige que tenhamos excelentes e inovadores periódicos. A Encontros Bibli: revista de biblioteconomia e ciência da informação é pioneira, sendo a primeira revista exclusivamente digital da Ciência da Informação no Brasil.Em 1996, no dia 09 de maio, a revista Encontros Bibli, por iniciativa do então Departamento de Biblioteconomia e Documentação, atual Departamento de Ciência da Informação da Universidade Federal de Santa Catarina (UFSC, ingressava na Web, a partir de seu primeiro número, utilizando a ferramenta HTML e mais tarde agregando outros recursos de edição, como a edição final dos textos em PDF. Desde então, tem se mantido neste ambiente, com periodicidade semestral e edições especiais.No ano 2003, a Encontros Bibli foi incluída na Rede de Revistas Cientificas da América Latina, Caribe, Espanha e Portugal (REDALYC e pelo Sistema Regional de Informaci

  6. A qualidade das publicações científicas: considerações de um Editor de Área ao final do mandato

    OpenAIRE

    Albuquerque,Ulysses Paulino de

    2009-01-01

    A qualidade das publicações científicas vem sendo discutida na atualidade considerando diferentes perspectivas. Neste texto, examina-se alguns dos principais problemas relativos à produção textual em ciência, com ênfase para os considerados de má conduta. Adicionalmente, são apresentadas sugestões para autores, revisores e editores no sentido de evitar condutas inadequadas no processo de publicação de trabalhos científicos.

  7. A Dutch Fanconi Anemia FANCC Founder Mutation in Canadian Manitoba Mennonites

    Directory of Open Access Journals (Sweden)

    Yne de Vries

    2012-01-01

    Full Text Available Fanconi anemia (FA is a recessive DNA instability disorder associated with developmental abnormalities, bone marrow failure, and a predisposition to cancer. Based on their sensitivity to DNA cross-linking agents, FA cells have been assigned to 15 complementation groups, and the associated genes have been identified. Founder mutations have been found in different FA genes in several populations. The majority of Dutch FA patients belongs to complementation group FA-C. Here, we report 15 patients of Dutch ancestry and a large Canadian Manitoba Mennonite kindred carrying the FANCC c.67delG mutation. Genealogical investigation into the ancestors of the Dutch patients shows that these ancestors lived in four distinct areas in The Netherlands. We also show that the Dutch and Manitoba Mennonite FANCC c.67delG patients share the same haplotype surrounding this mutation, indicating a common founder.

  8. Pervasive Genotypic Mosaicism in Founder Mice Derived from Genome Editing through Pronuclear Injection.

    Directory of Open Access Journals (Sweden)

    Daniel Oliver

    Full Text Available Genome editing technologies, especially the Cas9/CRISPR system, have revolutionized biomedical research over the past several years. Generation of novel alleles has been simplified to unprecedented levels, allowing for rapid expansion of available genetic tool kits for researchers. However, the issue of genotypic mosaicism has become evident, making stringent analyses of the penetrance of genome-edited alleles essential. Here, we report that founder mice, derived from pronuclear injection of ZFNs or a mix of guidance RNAs and Cas9 mRNAs, display consistent genotypic mosaicism for both deletion and insertion alleles. To identify founders with greater possibility of transmitting the mutant allele through the germline, we developed an effective germline genotyping method. The awareness of the inherent genotypic mosaicism issue with genome editing will allow for a more efficient implementation of the technologies, and the germline genotyping method will save valuable time and resources.

  9. Subspecies composition and founder contribution of the captive U.S. chimpanzee (Pan troglodytes) population.

    Science.gov (United States)

    Ely, John J; Dye, Brent; Frels, William I; Fritz, Jo; Gagneux, Pascal; Khun, Henry H; Switzer, William M; Lee, D Rick

    2005-10-01

    Chimpanzees are presently classified into three subspecies: Pan troglodytes verus from west Africa, P.t. troglodytes from central Africa, and P.t. schweinfurthii from east Africa. A fourth subspecies (P.t. vellerosus), from Cameroon and northern Nigeria, has been proposed. These taxonomic designations are based on geographical origins and are reflected in sequence variation in the first hypervariable region (HVR-I) of the mtDNA D-loop. Although advances have been made in our understanding of chimpanzee phylogenetics, little has been known regarding the subspecies composition of captive chimpanzees. We sequenced part of the mtDNA HVR-I region in 218 African-born population founders and performed a phylogenetic analysis with previously characterized African sequences of known provenance to infer subspecies affiliations. Most founders were P.t. verus (95.0%), distantly followed by the troglodytes schweinfurthii clade (4.6%), and a single P.t. vellerosus (0.4%). Pedigree-based estimates of genomic representation in the descendant population revealed that troglodytes schweinfurthii founder representation was reduced in captivity, vellerosus representation increased due to prolific breeding by a single male, and reproductive variance resulted in uneven representation among male P.t.verus founders. No increase in mortality was evident from between-subspecies interbreeding, indicating a lack of outbreeding depression. Knowledge of subspecies and their genomic representation can form the basis for phylogenetically informed genetic management of extant chimpanzees to preserve rare genetic variation for research, conservation, or possible future breeding. Copyright 2005 Wiley-Liss, Inc.

  10. A serial founder effect model for human settlement out of Africa

    OpenAIRE

    Deshpande, Omkar; Batzoglou, Serafim; Feldman, Marcus W.; Luca Cavalli-Sforza, L.

    2008-01-01

    The increasing abundance of human genetic data has shown that the geographical patterns of worldwide genetic diversity are best explained by human expansion out of Africa. This expansion is modelled well by prolonged migration from a single origin in Africa with multiple subsequent serial founding events. We discuss a new simulation model for the serial founder effect out of Africa and compare it with results from previous studies. Unlike previous models, we distinguish colonization events fr...

  11. The scribe of the founder's inscription of Saint Sava in Studenica

    Directory of Open Access Journals (Sweden)

    Špadijer Irena

    2006-01-01

    Full Text Available The founder's inscription situated at the foot of the tambour in the Church of the Virgin in Studenica originating from 1208/9, is one of the oldest dated specimens of Serbian literacy. It was uncovered in 1951, during the conservation works in the monastery. Former research (conducted by Dj. Trifunović, has ascertained that inscriptions on the scrolls, books and frescoes in the monastery were written by the Greek artists who decorated the church. Scribal errors indicate beyond any doubt that Slavic was not the mother tongue of the scribes, and that they were not, or at least not sufficiently, familiar with the orthography of this language. In this paper the main focus has been directed at the founder's inscription, which has been put under detailed orthographic and palaeographic scrutiny. The morphology of some letters — the Greek "K", non-distinguishing between ižica (ippsilon and the Cyrillic "Č" — clearly indicates that in all probability the author of the inscription was a Greek, perhaps the very painter who signed his name in the Greek language on the Mandelion beneath the large founder's inscription.

  12. Clinical applications and implications of common and founder mutations in Indian subpopulations.

    Science.gov (United States)

    Ankala, Arunkanth; Tamhankar, Parag M; Valencia, C Alexander; Rayam, Krishna K; Kumar, Manisha M; Hegde, Madhuri R

    2015-01-01

    South Asian Indians represent a sixth of the world's population and are a racially, geographically, and genetically diverse people. Their unique anthropological structure, prevailing caste system, and ancient religious practices have all impacted the genetic composition of most of the current-day Indian population. With the evolving socio-religious and economic activities of the subsects and castes, endogamous and consanguineous marriages became a commonplace. Consequently, the frequency of founder mutations and the burden of heritable genetic disorders rose significantly. Specifically, the incidence of certain autosomal-recessive disorders is relatively high in select Indian subpopulations and communities that share common recent ancestry. Although today clinical genetics and molecular diagnostic services are making inroads in India, the high costs associated with the technology and the tests often keep patients from an exact molecular diagnosis, making more customized and tailored tests, such as those interrogating the most common and founder mutations or those that cater to select sects within the population, highly attractive. These tests offer a quick first-hand affordable diagnostic and carrier screening tool. Here, we provide a comprehensive catalog of known common mutations and founder mutations in the Indian population and discuss them from a molecular, clinical, and historical perspective. © 2014 WILEY PERIODICALS, INC.

  13. The founder-cell transcriptome in the Arabidopsis apetala1 cauliflower inflorescence meristem.

    Science.gov (United States)

    Frerichs, Anneke; Thoma, Rahere; Abdallah, Ali Taleb; Frommolt, Peter; Werr, Wolfgang; Chandler, John William

    2016-11-03

    Although the pattern of lateral organ formation from apical meristems establishes species-specific plant architecture, the positional information that confers cell fate to cells as they transit to the meristem flanks where they differentiate, remains largely unknown. We have combined fluorescence-activated cell sorting and RNA-seq to characterise the cell-type-specific transcriptome at the earliest developmental time-point of lateral organ formation using DORNRÖSCHEN-LIKE::GFP to mark founder-cell populations at the periphery of the inflorescence meristem (IM) in apetala1 cauliflower double mutants, which overproliferate IMs. Within the lateral organ founder-cell population at the inflorescence meristem, floral primordium identity genes are upregulated and stem-cell identity markers are downregulated. Additional differentially expressed transcripts are involved in polarity generation and boundary formation, and in epigenetic and post-translational changes. However, only subtle transcriptional reprogramming within the global auxin network was observed. The transcriptional network of differentially expressed genes supports the hypothesis that lateral organ founder-cell specification involves the creation of polarity from the centre to the periphery of the IM and the establishment of a boundary from surrounding cells, consistent with bract initiation. However, contrary to the established paradigm that sites of auxin response maxima pre-pattern lateral organ initiation in the IM, auxin response might play a minor role in the earliest stages of lateral floral initiation.

  14. A mitochondrial analysis reveals distinct founder effect signatures in Canarian and Balearic goats.

    Science.gov (United States)

    Ferrando, A; Manunza, A; Jordana, J; Capote, J; Pons, A; Pais, J; Delgado, T; Atoche, P; Cabrera, B; Martínez, A; Landi, V; Delgado, J V; Argüello, A; Vidal, O; Lalueza-Fox, C; Ramírez, O; Amills, M

    2015-08-01

    In the course of human migrations, domestic animals often have been translocated to islands with the aim of assuring food availability. These founder events are expected to leave a genetic footprint that may be recognised nowadays. Herewith, we have examined the mitochondrial diversity of goat populations living in the Canarian and Balearic archipelagos. Median-joining network analysis produced very distinct network topologies for these two populations. Indeed, a majority of Canarian goats shared a single ancestral haplotype that segregated in all sampled islands, suggesting a single founder effect followed by a stepping-stone pattern of diffusion. This haplotype also was present in samples collected from archaeological assemblies at Gran Canaria and Lanzarote, making evident its widespread distribution in ancient times. In stark contrast, goats from Majorca and Ibiza did not share any mitochondrial haplotypes, indicating the occurrence of two independent founder events. Furthermore, in Majorcan goats, we detected the segregation of the mitochondrial G haplogroup that has only been identified in goats from Egypt, Iran and Turkey. This finding suggests the translocation of Asian and/or African goats to Majorca, possibly as a consequence of the Phoenician and Carthaginian colonisations of this island. © 2015 Stichting International Foundation for Animal Genetics.

  15. THE INFLUENCE OF THE COMPETENCES OF THE MANAGER: FOUNDER ON THE SUCCESS OF THE ORGANIZATION

    Directory of Open Access Journals (Sweden)

    Ace Milenkovski

    2013-06-01

    Full Text Available The environment, where the changes are everyday occurrence and the competition continuous threat, forces the leading people in the organizations to look after everything that goes on inside the organizations, as well as everything that goes on outside of them. Thus, depending on the founder’s capability, respectively the manager of the organization, the success of the organization can go up or down. The individuals that have entrepreneurial spirit, that know how to combine their knowledge, education and work experience with the successful guiding of the employees toward the goal, strengthen their business and open possibilities for its expansion.If under competence we imply to the knowledge of business, working experience and skills necessary for effective performance at the workplace, then undoubtedly the entrepreneur–founder in order to obtain the optimum knowledge for the business that he starts, previously has to build his competences through appropriate education and work experience.Herein we present working research conducted in order to prove the connection of the organization’s success with the knowledge, skills and competences for the corresponding business of the organization’s founder, particularly if the founder is also general manager of the organization. This research is conducted within the frames of the scientific and research activity of the University of Tourism and Management in Skopje, FYRO Macedonia.As a research sample 271 respondents – employees and 10 leaders of the companies included in the research. The leaders are managers and founders of the private companies. As a research technique questionnaire is used. Practical aim of the research was to use the results in order to create a basis for improving the performance of companies by developing the competencies of the management teams in them. One of the main conclusions of the research is: The manager-founder who starts up a business, needs to have optimum

  16. Differences in the Selection Bottleneck between Modes of Sexual Transmission Influence the Genetic Composition of the HIV-1 Founder Virus.

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    Damien C Tully

    2016-05-01

    Full Text Available Due to the stringent population bottleneck that occurs during sexual HIV-1 transmission, systemic infection is typically established by a limited number of founder viruses. Elucidation of the precise forces influencing the selection of founder viruses may reveal key vulnerabilities that could aid in the development of a vaccine or other clinical interventions. Here, we utilize deep sequencing data and apply a genetic distance-based method to investigate whether the mode of sexual transmission shapes the nascent founder viral genome. Analysis of 74 acute and early HIV-1 infected subjects revealed that 83% of men who have sex with men (MSM exhibit a single founder virus, levels similar to those previously observed in heterosexual (HSX transmission. In a metadata analysis of a total of 354 subjects, including HSX, MSM and injecting drug users (IDU, we also observed no significant differences in the frequency of single founder virus infections between HSX and MSM transmissions. However, comparison of HIV-1 envelope sequences revealed that HSX founder viruses exhibited a greater number of codon sites under positive selection, as well as stronger transmission indices possibly reflective of higher fitness variants. Moreover, specific genetic "signatures" within MSM and HSX founder viruses were identified, with single polymorphisms within gp41 enriched among HSX viruses while more complex patterns, including clustered polymorphisms surrounding the CD4 binding site, were enriched in MSM viruses. While our findings do not support an influence of the mode of sexual transmission on the number of founder viruses, they do demonstrate that there are marked differences in the selection bottleneck that can significantly shape their genetic composition. This study illustrates the complex dynamics of the transmission bottleneck and reveals that distinct genetic bottleneck processes exist dependent upon the mode of HIV-1 transmission.

  17. Investigações sobre o ensino de Genética e Biologia Molecular no Ensino Médio brasileiro: reflexões sobre as publicações científicas

    OpenAIRE

    Melo,José Romário de; Carmo,Edinaldo Medeiros

    2009-01-01

    Com o objetivo de analisar as publicações relacionadas ao ensino de Genética e Biologia Molecular no Ensino Médio brasileiro, foram consideradas reflexões sobre várias publicações científicas mediante revisão bibliográfica. Foram analisados trabalhos publicados entre 1999 a 2008. A Revista Genética na Escola se destacou quanto à quantidade de artigos publicados. As publicações puderam ser classificadas em diversas categorias, como: análise de livro didático (ALD), histórico (HIS), intrainterd...

  18. Constitutional Mismatch Repair Deficiency in Israel: High Proportion of Founder Mutations in MMR Genes and Consanguinity.

    Science.gov (United States)

    Baris, Hagit N; Barnes-Kedar, Inbal; Toledano, Helen; Halpern, Marisa; Hershkovitz, Dov; Lossos, Alexander; Lerer, Israela; Peretz, Tamar; Kariv, Revital; Cohen, Shlomi; Half, Elizabeth E; Magal, Nurit; Drasinover, Valerie; Wimmer, Katharina; Goldberg, Yael; Bercovich, Dani; Levi, Zohar

    2016-03-01

    Heterozygous germline mutations in any of the mismatch repair (MMR) genes, MLH1, MSH2, MSH6, and PMS2, cause Lynch syndrome (LS), an autosomal dominant cancer predisposition syndrome conferring a high risk of colorectal, endometrial, and other cancers in adulthood. Offspring of couples where both spouses have LS have a 1:4 risk of inheriting biallelic MMR gene mutations. These cause constitutional MMR deficiency (CMMRD) syndrome, a severe recessively inherited cancer syndrome with a broad tumor spectrum including mainly hematological malignancies, brain tumors, and colon cancer in childhood and adolescence. Many CMMRD children also present with café au lait spots and axillary freckling mimicking neurofibromatosis type 1. We describe our experience in seven CMMRD families demonstrating the role and importance of founder mutations and consanguinity on its prevalence. Clinical presentations included brain tumors, colon cancer, lymphoma, and small bowel cancer. In children from two nonconsanguineous Ashkenazi Jewish (AJ) families, the common Ashkenazi founder mutations were detected; these were homozygous in one family and compound heterozygous in the other. In four consanguineous families of various ancestries, different homozygous mutations were identified. In a nonconsanguineous Caucasus/AJ family, lack of PMS2 was demonstrated in tumor and normal tissues; however, mutations were not identified. CMMRD is rare, but, especially in areas where founder mutations for LS and consanguinity are common, pediatricians should be aware of it since they are the first to encounter these children. Early diagnosis will enable tailored cancer surveillance in the entire family and a discussion regarding prenatal genetic diagnosis. © 2015 Wiley Periodicals, Inc.

  19. Rayleigh and S wave tomography constraints on subduction termination and lithospheric foundering in central California

    Science.gov (United States)

    Jiang, Chengxin; Schmandt, Brandon; Hansen, Steven M.; Dougherty, Sara L.; Clayton, Robert W.; Farrell, Jamie; Lin, Fan-Chi

    2018-01-01

    The crust and upper mantle structure of central California have been modified by subduction termination, growth of the San Andreas plate boundary fault system, and small-scale upper mantle convection since the early Miocene. Here we investigate the contributions of these processes to the creation of the Isabella Anomaly, which is a high seismic velocity volume in the upper mantle. There are two types of hypotheses for its origin. One is that it is the foundered mafic lower crust and mantle lithosphere of the southern Sierra Nevada batholith. The alternative suggests that it is a fossil slab connected to the Monterey microplate. A dense broadband seismic transect was deployed from the coast to the western Sierra Nevada to fill in the least sampled areas above the Isabella Anomaly, and regional-scale Rayleigh and S wave tomography are used to evaluate the two hypotheses. New shear velocity (Vs) tomography images a high-velocity anomaly beneath coastal California that is sub-horizontal at depths of ∼40–80 km. East of the San Andreas Fault a continuous extension of the high-velocity anomaly dips east and is located beneath the Sierra Nevada at ∼150–200 km depth. The western position of the Isabella Anomaly in the uppermost mantle is inconsistent with earlier interpretations that the Isabella Anomaly is connected to actively foundering foothills lower crust. Based on the new Vs images, we interpret that the Isabella Anomaly is not the dense destabilized root of the Sierra Nevada, but rather a remnant of Miocene subduction termination that is translating north beneath the central San Andreas Fault. Our results support the occurrence of localized lithospheric foundering beneath the high elevation eastern Sierra Nevada, where we find a lower crustal low Vs layer consistent with a small amount of partial melt. The high elevations relative to crust thickness and lower crustal low Vs zone are consistent with geological inferences that lithospheric foundering drove

  20. Rayleigh and S wave tomography constraints on subduction termination and lithospheric foundering in central California

    Science.gov (United States)

    Jiang, Chengxin; Schmandt, Brandon; Hansen, Steven M.; Dougherty, Sara L.; Clayton, Robert W.; Farrell, Jamie; Lin, Fan-Chi

    2018-04-01

    The crust and upper mantle structure of central California have been modified by subduction termination, growth of the San Andreas plate boundary fault system, and small-scale upper mantle convection since the early Miocene. Here we investigate the contributions of these processes to the creation of the Isabella Anomaly, which is a high seismic velocity volume in the upper mantle. There are two types of hypotheses for its origin. One is that it is the foundered mafic lower crust and mantle lithosphere of the southern Sierra Nevada batholith. The alternative suggests that it is a fossil slab connected to the Monterey microplate. A dense broadband seismic transect was deployed from the coast to the western Sierra Nevada to fill in the least sampled areas above the Isabella Anomaly, and regional-scale Rayleigh and S wave tomography are used to evaluate the two hypotheses. New shear velocity (Vs) tomography images a high-velocity anomaly beneath coastal California that is sub-horizontal at depths of ∼40-80 km. East of the San Andreas Fault a continuous extension of the high-velocity anomaly dips east and is located beneath the Sierra Nevada at ∼150-200 km depth. The western position of the Isabella Anomaly in the uppermost mantle is inconsistent with earlier interpretations that the Isabella Anomaly is connected to actively foundering foothills lower crust. Based on the new Vs images, we interpret that the Isabella Anomaly is not the dense destabilized root of the Sierra Nevada, but rather a remnant of Miocene subduction termination that is translating north beneath the central San Andreas Fault. Our results support the occurrence of localized lithospheric foundering beneath the high elevation eastern Sierra Nevada, where we find a lower crustal low Vs layer consistent with a small amount of partial melt. The high elevations relative to crust thickness and lower crustal low Vs zone are consistent with geological inferences that lithospheric foundering drove uplift

  1. Fatores de impacto de publicações psiquiátricas e produtividade científica

    Directory of Open Access Journals (Sweden)

    Elkis Helio

    1999-01-01

    Full Text Available OBJETIVO: Mostrar que alguns índices bibliométricos, como o Fator de Impacto (FI e a análise de citações, são úteis para avaliação da repercussão científica de publicações psiquiátricas. Tais índices podem também ser empregados na avaliação de produtividade científica individual. MÉTODOS: Os fatores de impacto de periódicos psiquiátricos dos anos de 1995 e 1997 foram obtidos através do "Journal of Citation Reports". As curvas de distribuição foram analisadas através de histogramas e gráficos tipo caixa (box-plots. As médias das avaliações de 1995 e 1997 foram comparadas através do teste de soma de postos de Wilcoxon. RESULTADOS: As curvas de distribuição dos fatores de impacto em 1995 e 1997 mostraram não obedecer a uma distribuição normal. A média de ambas as avaliações girou em torno de 1,5. Houve um aumento significativo na média dos fatores de impacto de 1995 para 1997 ( Wilcoxon W=57 p=0,026. Três periódicos mantiveram os seus fatores de impacto várias vezes acima da média geral em ambas as avaliações ("outliers": "Archives of General Psychiatry", "American Journal of Psychiatry" e "Journal of Clinical Psychopharmacology". CONCLUSÕES: Os fatores de impacto são os melhores índices para avaliação do desempenho científico de publicações psiquiátricas. No entanto, no caso de avaliações da produtividade científica individual, esta também deve ser avaliada através de uma análise de citações.

  2. The nuclear power policy in Argentina (1965-2003); La politica publica de generacion nucleoelectrica en la Republica Argentina (1965-2003)

    Energy Technology Data Exchange (ETDEWEB)

    Carreiro, Francisco M [Buenos Aires Univ. (Argentina). Facultad de Ciencias Economicas

    2005-07-01

    This paper aims to expose some outcomes of a larger research on the nuclear power plants public policy review in Argentine, between 1965 and 2003. It points out the relevance of institutional design as a main factor to explain the policy evolution, and offers unpublished statistic data of this nuclear energy sector. Finally, some comments are presented in order to highlight the importance of the unsolved policy aspects that concern the decision makers in this area. (author) [Spanish] El presente trabajo deriva de un estudio integral desde la optica de la politica publica, y tiene como objetivo el analisis de la evolucion de la politica publica de generacion nucleoelectrica en la Republica Argentina entre los anios 1965 y 2003. (autor)

  3. Haplotype analysis suggest that the MLH1 c.2059C > T mutation is a Swedish founder mutation.

    Science.gov (United States)

    von Salomé, Jenny; Liu, Tao; Keihäs, Markku; Morak, Moni; Holinski-Feder, Elke; Berry, Ian R; Moilanen, Jukka S; Baert-Desurmont, Stéphanie; Lindblom, Annika; Lagerstedt-Robinson, Kristina

    2017-12-29

    Lynch syndrome (LS) predisposes to a spectrum of cancers and increases the lifetime risk of developing colorectal- or endometrial cancer to over 50%. Lynch syndrome is dominantly inherited and is caused by defects in DNA mismatch-repair genes MLH1, MSH2, MSH6 or PMS2, with the vast majority detected in MLH1 and MSH2. Recurrent LS-associated variants observed in apparently unrelated individuals, have either arisen de novo in different families due to mutation hotspots, or are inherited from a founder (a common ancestor) that lived several generations back. There are variants that recur in some populations while also acting as founders in other ethnic groups. Testing for founder mutations can facilitate molecular diagnosis of Lynch Syndrome more efficiently and more cost effective than screening for all possible mutations. Here we report a study of the missense mutation MLH1 c.2059C > T (p.Arg687Trp), a potential founder mutation identified in eight Swedish families and one Finnish family with Swedish ancestors. Haplotype analysis confirmed that the Finnish and Swedish families shared a haplotype of between 0.9 and 2.8 Mb. While MLH1 c.2059C > T exists worldwide, the Swedish haplotype was not found among mutation carriers from Germany or France, which indicates a common founder in the Swedish population. The geographic distribution of MLH1 c.2059C > T in Sweden suggests a single, ancient mutational event in the northern part of Sweden.

  4. Association of yield-related traits in founder genotypes and derivatives of common wheat (Triticum aestivum L.

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    Jie Guo

    2018-02-01

    Full Text Available Abstract Background Yield improvement is an ever-important objective of wheat breeding. Studying and understanding the phenotypes and genotypes of yield-related traits has potential for genetic improvement of crops. Results The genotypes of 215 wheat cultivars including 11 founder parents and 106 derivatives were analyzed by the 9 K wheat SNP iSelect assay. A total of 4138 polymorphic single nucleotide polymorphism (SNP loci were detected on 21 chromosomes, of which 3792 were mapped to single chromosome locations. All genotypes were phenotyped for six yield-related traits including plant height (PH, spike length (SL, spikelet number per spike (SNPS, kernel number per spike (KNPS, kernel weight per spike (KWPS, and thousand kernel weight (TKW in six irrigated environments. Genome-wide association analysis detected 117 significant associations of 76 SNPs on 15 chromosomes with phenotypic explanation rates (R 2 ranging from 2.03 to 12.76%. In comparing allelic variation between founder parents and their derivatives (106 and other cultivars (98 using the 76 associated SNPs, we found that the region 116.0–133.2 cM on chromosome 5A in founder parents and derivatives carried alleles positively influencing kernel weight per spike (KWPS, rarely found in other cultivars. Conclusion The identified favorable alleles could mark important chromosome regions in derivatives that were inherited from founder parents. Our results unravel the genetic of yield in founder genotypes, and provide tools for marker-assisted selection for yield improvement.

  5. High prevalence of BRCA1 founder mutations in Greek breast/ovarian families.

    Science.gov (United States)

    Konstantopoulou, I; Tsitlaidou, M; Fostira, F; Pertesi, M; Stavropoulou, A-V; Triantafyllidou, O; Tsotra, E; Tsiftsoglou, A P; Tsionou, C; Droufakou, S; Dimitrakakis, C; Fountzilas, G; Yannoukakos, D

    2014-01-01

    We have screened 473 breast/ovarian cancer patients with family history, aiming to define the prevalence and enrich the spectrum of BRCA1/2 pathogenic mutations occurring in the Greek population. An overall mutation prevalence of 32% was observed. Six BRCA1 recurrent/founder mutations dominate the observed spectrum (58.5% of all mutations found). These include three mutations in exon 20 and three large genomic deletions. Of the 44 different deleterious mutations found in both genes, 16 are novel and reported here for the first time. Correlation with available histopathology data showed that 80% of BRCA1 carriers presented a triple-negative breast cancer phenotype while 82% of BRCA2 carriers had oestrogen receptor positive tumours. This study provides a comprehensive view of the frequency, type and distribution of BRCA1/2 mutations in the Greek population as well as an insight of the screening strategy of choice for patients of Greek origin. We conclude that the Greek population has a diverse mutation spectrum influenced by strong founder effects. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  6. PRIMAL: Fast and accurate pedigree-based imputation from sequence data in a founder population.

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    Oren E Livne

    2015-03-01

    Full Text Available Founder populations and large pedigrees offer many well-known advantages for genetic mapping studies, including cost-efficient study designs. Here, we describe PRIMAL (PedigRee IMputation ALgorithm, a fast and accurate pedigree-based phasing and imputation algorithm for founder populations. PRIMAL incorporates both existing and original ideas, such as a novel indexing strategy of Identity-By-Descent (IBD segments based on clique graphs. We were able to impute the genomes of 1,317 South Dakota Hutterites, who had genome-wide genotypes for ~300,000 common single nucleotide variants (SNVs, from 98 whole genome sequences. Using a combination of pedigree-based and LD-based imputation, we were able to assign 87% of genotypes with >99% accuracy over the full range of allele frequencies. Using the IBD cliques we were also able to infer the parental origin of 83% of alleles, and genotypes of deceased recent ancestors for whom no genotype information was available. This imputed data set will enable us to better study the relative contribution of rare and common variants on human phenotypes, as well as parental origin effect of disease risk alleles in >1,000 individuals at minimal cost.

  7. Can a linguistic serial founder effect originating in Africa explain the worldwide phonemic cline?

    Science.gov (United States)

    Fort, Joaquim; Pérez-Losada, Joaquim

    2016-04-01

    It has been proposed that a serial founder effect could have caused the present observed pattern of global phonemic diversity. Here we present a model that simulates the human range expansion out of Africa and the subsequent spatial linguistic dynamics until today. It does not assume copying errors, Darwinian competition, reduced contrastive possibilities or any other specific linguistic mechanism. We show that the decrease of linguistic diversity with distance (from the presumed origin of the expansion) arises under three assumptions, previously introduced by other authors: (i) an accumulation rate for phonemes; (ii) small phonemic inventories for the languages spoken before the out-of-Africa dispersal; (iii) an increase in the phonemic accumulation rate with the number of speakers per unit area. Numerical simulations show that the predictions of the model agree with the observed decrease of linguistic diversity with increasing distance from the most likely origin of the out-of-Africa dispersal. Thus, the proposal that a serial founder effect could have caused the present observed pattern of global phonemic diversity is viable, if three strong assumptions are satisfied. © 2016 The Authors.

  8. A.T. STILL (1828–1917, THE FOUNDER OF OSTEOPATHY: THE COURSE OF LIFE

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    V. I. Karpova

    2016-01-01

    Full Text Available Osteopathy is a young medical specialty that has found official acceptance in Russia since 2013. The paper deals with the history of osteo pathy and its founder Andrew Taylor Still (1828–1917. He left a few printed scientific works, including his biography reporting much of his life and activities and the creation of osteopathy. The emergence date of osteopathy is considered to be 22 June 1874. Historically, modern osteopathy has come into existence not so long. We are almost contemporaries of it and its author, but despite this, the international osteopathy community is romanticizing and mythologizing the personality of A.T. Still. In our opinion, the reason is his magnetic personality and brilliant life. Thanks to A.T. Still’s personality, osteopathy may not have been lost among many medical areas and discoveries and continues to develop and attract new supporters. On the other hand, osteopathy is, in the opinion of its founder, a science; therefore a historical rather than mythological approach to A.T. Still’s bibliography, which takes into account all factors for personality formation, is considered correct. Modern science tells that these factors are inheritance, environment, and education. The authors have applied just this scientific approach and, without demolishing the myths, set forth an aim to study the factors forming the world outlook of A.T. Still in order to predict a further way to develope osteopathy in our country.

  9. Can a linguistic serial founder effect originating in Africa explain the worldwide phonemic cline?

    Science.gov (United States)

    2016-01-01

    It has been proposed that a serial founder effect could have caused the present observed pattern of global phonemic diversity. Here we present a model that simulates the human range expansion out of Africa and the subsequent spatial linguistic dynamics until today. It does not assume copying errors, Darwinian competition, reduced contrastive possibilities or any other specific linguistic mechanism. We show that the decrease of linguistic diversity with distance (from the presumed origin of the expansion) arises under three assumptions, previously introduced by other authors: (i) an accumulation rate for phonemes; (ii) small phonemic inventories for the languages spoken before the out-of-Africa dispersal; (iii) an increase in the phonemic accumulation rate with the number of speakers per unit area. Numerical simulations show that the predictions of the model agree with the observed decrease of linguistic diversity with increasing distance from the most likely origin of the out-of-Africa dispersal. Thus, the proposal that a serial founder effect could have caused the present observed pattern of global phonemic diversity is viable, if three strong assumptions are satisfied. PMID:27122180

  10. Haplotype variation in founders of the Mauremys annamensis population kept in European Zoos

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    Barbora Somerova

    2015-06-01

    Full Text Available The critically endangered Annam leaf turtle Mauremys annamensis faces extinction in nature. Because of that, the conservation value of the population kept in European zoos becomes substantial for reintroduction programmes. We sampled 39 specimens of M. annamensis from European zoos and other collections (mainly founders, imports and putatively unrelated individuals, and also four specimens of Mauremys mutica for comparison. In each animal, we sequenced 817 bp of the mitochondrial ND4 gene and 940 bp of the nuclear R35 intron that were used as phylogenetic markers for Mauremys mutica-annamensis group by previous authors. The sequences of the R35 intron, which are characteristic for M. annamensis and which clearly differ from those characteristic for M. mutica and/or other Mauremys species, were mutually shared by all of the examined M. annamensis. They also possessed mitochondrial haplotypes belonging to the annamensis subclades I and II, distinctness of which was clearly confirmed by phylogenetic analyses. Thus, both nuclear and mitochondrial markers agreed in the unequivocal assignment of the examined individuals to M. annamensis. Although no obvious hybrids were detected within the founders of the captive population, further careful genetic evaluation using genom-wide markers is required to unequivocally confirm this result.

  11. Publicação Eletrônica: a linguagem do e-book na hipermídia

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    Daniela Carvalho Monteiro Ferreira

    2013-12-01

    Full Text Available O e-Book é um ambiente virtual e os formatos ePub e Daisy são um conjunto de arquivos interconectados, com potencial de utilização de fontes externas de informação, o que os tornam uma hipermídia. O objetivo deste artigo é apresentar os primeiros resultados sobre a utilização do quadro metodológico de planejamento do conteúdo audiovisual na edição de e-Book. Verificou-se que, assim como na web, os formatos ePub e Daisy, e em especial o primeiro, possui o potencial de utilização de recursos audiovisuais que podem fazer do resultado extrapolar a linguagem tradicional do livro impresso, tornando-os multimídia. Surge então o questionamento sobre o papel do editor de e-Book enquanto publicação eletrônica baseado no hipertexto, que assemelha-se com o de um roteirista para hipermídia.

  12. Os usos sociais do dinheiro em circuitos filantrópicos: o caso das "publicações de rua"

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    Ariel Wilkis

    2008-04-01

    Full Text Available A partir de um estudo de caso centrado em uma organização que edita uma revista vendida por pessoas "sem teto" na cidade de Buenos Aires, me interrogo sobre os usos sociais do dinheiro em circuitos filantrópicos. Ao seguir a polêmica entre dinheiro e dom, que está no centro das discussões da antropologia e da sociologia, enfoco duas questões: a o papel do dinheiro para demarcar os limites entre as "transações mercantis" e as "circulações de dons"; b a relação entre dinheiro e moral. O trabalho de campo consistiu em uma etnografia das transações entre os vendedores e os compradores desta publicação.Based on a case study of an organization responsible for publishing a magazine sold to ‘homeless’ people in Buenos Aires, I examine the social uses of money in philanthropic circles. Turning to the polemic between money and gift at the centre of discussions in anthropology and sociology, I focus on two questions: a the role of money in demarcating the limits between ‘market transactions’ and ‘gift circulations’; b the relation between money and morality. Fieldwork involved an ethnographic study of the transactions between the sellers and buyers of this publication.

  13. Signatures of seaway closures and founder dispersal in the phylogeny of a circumglobally distributed seahorse lineage.

    Science.gov (United States)

    Teske, Peter R; Hamilton, Healy; Matthee, Conrad A; Barker, Nigel P

    2007-08-15

    The importance of vicariance events on the establishment of phylogeographic patterns in the marine environment is well documented, and generally accepted as an important cause of cladogenesis. Founder dispersal (i.e. long-distance dispersal followed by founder effect speciation) is also frequently invoked as a cause of genetic divergence among lineages, but its role has long been challenged by vicariance biogeographers. Founder dispersal is likely to be common in species that colonize remote habitats by means of rafting (e.g. seahorses), as long-distance dispersal events are likely to be rare and subsequent additional recruitment from the source habitat is unlikely. In the present study, the relative importance of vicariance and founder dispersal as causes of cladogenesis in a circumglobally distributed seahorse lineage was investigated using molecular dating. A phylogeny was reconstructed using sequence data from mitochondrial and nuclear markers, and the well-documented closure of the Central American seaway was used as a primary calibration point to test whether other bifurcations in the phylogeny could also have been the result of vicariance events. The feasibility of three other vicariance events was explored: a) the closure of the Indonesian Seaway, resulting in sister lineages associated with the Indian Ocean and West Pacific, respectively; b) the closure of the Tethyan Seaway, resulting in sister lineages associated with the Indo-Pacific and Atlantic Ocean, respectively, and c) continental break-up during the Mesozoic followed by spreading of the Atlantic Ocean, resulting in pairs of lineages with amphi-Atlantic distribution patterns. Comparisons of pairwise genetic distances among the seahorse species hypothesized to have diverged as a result of the closure of the Central American Seaway with those of published teleost sequences having the same distribution patterns show that the seahorses were among the last to diverge. This suggests that their

  14. Signatures of seaway closures and founder dispersal in the phylogeny of a circumglobally distributed seahorse lineage

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    Matthee Conrad A

    2007-08-01

    Full Text Available Abstract Background The importance of vicariance events on the establishment of phylogeographic patterns in the marine environment is well documented, and generally accepted as an important cause of cladogenesis. Founder dispersal (i.e. long-distance dispersal followed by founder effect speciation is also frequently invoked as a cause of genetic divergence among lineages, but its role has long been challenged by vicariance biogeographers. Founder dispersal is likely to be common in species that colonize remote habitats by means of rafting (e.g. seahorses, as long-distance dispersal events are likely to be rare and subsequent additional recruitment from the source habitat is unlikely. In the present study, the relative importance of vicariance and founder dispersal as causes of cladogenesis in a circumglobally distributed seahorse lineage was investigated using molecular dating. A phylogeny was reconstructed using sequence data from mitochondrial and nuclear markers, and the well-documented closure of the Central American seaway was used as a primary calibration point to test whether other bifurcations in the phylogeny could also have been the result of vicariance events. The feasibility of three other vicariance events was explored: a the closure of the Indonesian Seaway, resulting in sister lineages associated with the Indian Ocean and West Pacific, respectively; b the closure of the Tethyan Seaway, resulting in sister lineages associated with the Indo-Pacific and Atlantic Ocean, respectively, and c continental break-up during the Mesozoic followed by spreading of the Atlantic Ocean, resulting in pairs of lineages with amphi-Atlantic distribution patterns. Results Comparisons of pairwise genetic distances among the seahorse species hypothesized to have diverged as a result of the closure of the Central American Seaway with those of published teleost sequences having the same distribution patterns show that the seahorses were among the last to

  15. Avaliação do autoconceito no contexto escolar: análise das publicações em periódicos brasileiros

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    Adriana Cristina Boulhoça Suehiro

    Full Text Available Visando a levantar as publicações dos últimos dez anos referentes à avaliação do autoconceito no contexto escolar, o presente estudo avaliou artigos encontrados nos periódicos classificados como Nacional A pela CAPES. Os dados evidenciaram poucas publicações voltadas para a avaliação do construto. Mesmo os periódicos específicos de Psicologia escolar e educacionalpassaram a publicar artigos sobre o assunto somente a partir de 2005. Nas análises por Região, autoria e amostras, o Sudeste apresentou maior concentração de artigos publicados. Foi identificado o uso mais freqüente da autoria múltipla e a realização de estudos envolvendo crianças. As referências apresentaram mais artigos e livros, com predominância da literatura internacional. Quanto aos instrumentos de avaliação, os mais utilizados foram a Escala Infantil Piers-Harris e a Escala de Autoconceito Infanto-Juvenil EAC-IJ. Por fim, o presente estudo atesta a necessidade de novas publicações voltadas para a avaliação do autoconceito no contexto escolar, guiado pela importância do construto no processo de aprendizagem.

  16. Eduard Strasburger (1844-1912): founder of modern plant cell biology.

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    Volkmann, Dieter; Baluška, František; Menzel, Diedrik

    2012-10-01

    Eduard Strasburger, director of the Botany Institute and the Botanical Garden at the University of Bonn from 1881 to 1912, was one of the most admirable scientists in the field of plant biology, not just as the founder of modern plant cell biology but in addition as an excellent teacher who strongly believed in "education through science." He contributed to plant cell biology by discovering the discrete stages of karyokinesis and cytokinesis in algae and higher plants, describing cytoplasmic streaming in different systems, and reporting on the growth of the pollen tube into the embryo sac and guidance of the tube by synergides. Strasburger raised many problems which are hot spots in recent plant cell biology, e.g., structure and function of the plasmodesmata in relation to phloem loading (Strasburger cells) and signaling, mechanisms of cell plate formation, vesicle trafficking as a basis for most important developmental processes, and signaling related to fertilization.

  17. The founder of the church of Saint George at Pološko

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    Pavlović Dragana

    2015-01-01

    Full Text Available The paper seeks to establish who was the founder of the church of Saint George at Pološko and revise the conclusions of previous researchers regarding this issue. According to the opinion commonly adopted in the scholarly literature, Jovan Dragušin, a cousin of King Dušan, had merely undertaken the construction of church at Pološko, whereas his mother was responsible for the completion of construction and painting of frescoes in the church. Through an analysis of written and visual sources the conclusion is reached that the sole person responsible for the construction and painting of the church at Pološko was the nun Maria, the mother of Jovan Dragušin. [Projekat Ministarstva nauke Republike Srbije, br. 177036: Srpska srednjovekovna umetnost i njen evropski kontekst

  18. Preconception carrier screening for multiple disorders: evaluation of a screening offer in a Dutch founder population.

    Science.gov (United States)

    Mathijssen, Inge B; Holtkamp, Kim C A; Ottenheim, Cecile P E; van Eeten-Nijman, Janneke M C; Lakeman, Phillis; Meijers-Heijboer, Hanne; van Maarle, Merel C; Henneman, Lidewij

    2018-02-01

    Technological developments have enabled carrier screening for multiple disorders. This study evaluated experiences with a preconception carrier screening offer for four recessive disorders in a Dutch founder population. Questionnaires were completed by 182 attendees pretesting and posttesting and by 137 non-attendees. Semistructured interviews were conducted with seven of the eight carrier couples. Attendees were mainly informed about the existence of screening by friends/colleagues (49%) and family members (44%). Familiarity with the genetic disorders was high. Knowledge after counseling increased (p influencers (family/friends) can be used to raise awareness of a screening offer. Our findings provide lessons for the implementation of expanded carrier screening panels in other communities and other settings.

  19. XPC gene mutations in families with xeroderma pigmentosum from Pakistan; prevalent founder effect.

    Science.gov (United States)

    Ijaz, Ambreen; Basit, Sulman; Gul, Ajab; Batool, Lilas; Hussain, Abrar; Afzal, Sibtain; Ramzan, Khushnooda; Ahmad, Jamil; Wali, Abdul

    2018-03-23

    Xeroderma pigmentosum (XP) is a rare autosomal recessive skin disorder characterized by hyperpigmentation, premature skin aging, ocular and cutaneous photosensitivity, and increased risk of skin carcinoma. We investigated seven consanguineous XP families with nine patients from Pakistan. All the Patients exhibited typical clinical symptoms of XP since first year of life. Whole genome SNP genotyping identified a 14 Mb autozygous region segregating with the disease phenotype on chromosome 3p25.1. DNA sequencing of XPC gene revealed a founder homozygous splice site mutation (c.2251-1G>C) in patients from six families (A-F) and a homozygous nonsense mutation (c.1399C>T; p.Gln467*) in patients of family G. This is the first report of XPC mutations, underlying XP phenotype, in Pakistani population. © 2018 Japanese Teratology Society.

  20. Hematological consequences of a FANCG founder mutation in Black South African patients with Fanconi anemia.

    Science.gov (United States)

    Feben, Candice; Kromberg, Jennifer; Wainwright, Rosalind; Stones, David; Poole, Janet; Haw, Tabitha; Krause, Amanda

    2015-03-01

    Fanconi anemia (FA) is a rare disorder of DNA repair, associated with various somatic abnormalities but characterized by hematological disease that manifests as bone marrow aplasia and malignancy. The mainstay of treatment, in developed nations, is hematopoietic stem cell transplantation (HSCT) with subsequent surveillance for solid organ and non-hematological malignancies. In South Africa, FA in the Black population is caused by a homozygous deletion mutation in the FANCG gene in more than 80% of cases. Many affected patients are not diagnosed until late in the disease course when severe cytopenia and bone marrow aplasia are already present. Most patients are not eligible for HSCT at this late stage of the disease, even when it is available in the state health care system. In this study, the hematological presentation and disease progression in 30 Black South African patients with FA, confirmed to have the FANCG founder mutation, were evaluated and compared to those described in other FA cohorts. Our results showed that patients, homozygous for the FANCG founder mutation, present with severe cytopenia but progress to bone marrow failure at similar ages to other individuals affected with FA of heterogeneous genotype. Further, the incidence of myelodysplastic syndrome is similar to that which has been previously described in other FA cohorts. Although severe cytopenia at presentation may be predicted by a higher number of somatic anomalies, the recognition of the physical FA phenotype in Black South African patients is challenging and may not be useful in expediting referral of suspected FA patients for tertiary level investigations and care. Given the late but severe hematological presentation of FA in Black South African patients, an investigative strategy is needed for earlier recognition of affected individuals to allow for possible HSCT and management of bone marrow disease. Copyright © 2014 Elsevier Inc. All rights reserved.

  1. Brief communication: human cranial variation fits iterative founder effect model with African origin.

    Science.gov (United States)

    von Cramon-Taubadel, Noreen; Lycett, Stephen J

    2008-05-01

    Recent studies comparing craniometric and neutral genetic affinity matrices have concluded that, on average, human cranial variation fits a model of neutral expectation. While human craniometric and genetic data fit a model of isolation by geographic distance, it is not yet clear whether this is due to geographically mediated gene flow or human dispersal events. Recently, human genetic data have been shown to fit an iterative founder effect model of dispersal with an African origin, in line with the out-of-Africa replacement model for modern human origins, and Manica et al. (Nature 448 (2007) 346-349) have demonstrated that human craniometric data also fit this model. However, in contrast with the neutral model of cranial evolution suggested by previous studies, Manica et al. (2007) made the a priori assumption that cranial form has been subject to climatically driven natural selection and therefore correct for climate prior to conducting their analyses. Here we employ a modified theoretical and methodological approach to test whether human cranial variability fits the iterative founder effect model. In contrast with Manica et al. (2007) we employ size-adjusted craniometric variables, since climatic factors such as temperature have been shown to correlate with aspects of cranial size. Despite these differences, we obtain similar results to those of Manica et al. (2007), with up to 26% of global within-population craniometric variation being explained by geographic distance from sub-Saharan Africa. Comparative analyses using non-African origins do not yield significant results. The implications of these results are discussed in the light of the modern human origins debate. (c) 2007 Wiley-Liss, Inc.

  2. Distribution and medical impact of loss-of-function variants in the Finnish founder population.

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    Elaine T Lim

    2014-07-01

    Full Text Available Exome sequencing studies in complex diseases are challenged by the allelic heterogeneity, large number and modest effect sizes of associated variants on disease risk and the presence of large numbers of neutral variants, even in phenotypically relevant genes. Isolated populations with recent bottlenecks offer advantages for studying rare variants in complex diseases as they have deleterious variants that are present at higher frequencies as well as a substantial reduction in rare neutral variation. To explore the potential of the Finnish founder population for studying low-frequency (0.5-5% variants in complex diseases, we compared exome sequence data on 3,000 Finns to the same number of non-Finnish Europeans and discovered that, despite having fewer variable sites overall, the average Finn has more low-frequency loss-of-function variants and complete gene knockouts. We then used several well-characterized Finnish population cohorts to study the phenotypic effects of 83 enriched loss-of-function variants across 60 phenotypes in 36,262 Finns. Using a deep set of quantitative traits collected on these cohorts, we show 5 associations (p<5×10⁻⁸ including splice variants in LPA that lowered plasma lipoprotein(a levels (P = 1.5×10⁻¹¹⁷. Through accessing the national medical records of these participants, we evaluate the LPA finding via Mendelian randomization and confirm that these splice variants confer protection from cardiovascular disease (OR = 0.84, P = 3×10⁻⁴, demonstrating for the first time the correlation between very low levels of LPA in humans with potential therapeutic implications for cardiovascular diseases. More generally, this study articulates substantial advantages for studying the role of rare variation in complex phenotypes in founder populations like the Finns and by combining a unique population genetic history with data from large population cohorts and centralized research access to National Health

  3. The first Dutch SDHB founder deletion in paraganglioma – pheochromocytoma patients

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    Devilee Peter

    2009-04-01

    Full Text Available Abstract Background Germline mutations of the tumor suppressor genes SDHB, SDHC and SDHD play a major role in hereditary paraganglioma and pheochromocytoma. These three genes encode subunits of succinate dehydrogenase (SDH, the mitochondrial tricarboxylic acid cycle enzyme and complex II component of the electron transport chain. The majority of variants of the SDH genes are missense and nonsense mutations. To date few large deletions of the SDH genes have been described. Methods We carried out gene deletion scanning using MLPA in 126 patients negative for point mutations in the SDH genes. We then proceeded to the molecular characterization of deletions, mapping breakpoints in each patient and used haplotype analysis to determine whether the deletions are due to a mutation hotspot or if a common haplotype indicated a single founder mutation. Results A novel deletion of exon 3 of the SDHB gene was identified in nine apparently unrelated Dutch patients. An identical 7905 bp deletion, c.201-4429_287-933del, was found in all patients, resulting in a frameshift and a predicted truncated protein, p.Cys68HisfsX21. Haplotype analysis demonstrated a common haplotype at the SDHB locus. Index patients presented with pheochromocytoma, extra-adrenal PGL and HN-PGL. A lack of family history was seen in seven of the nine cases. Conclusion The identical exon 3 deletions and common haplotype in nine patients indicates that this mutation is the first Dutch SDHB founder mutation. The predominantly non-familial presentation of these patients strongly suggests reduced penetrance. In this small series HN-PGL occurs as frequently as pheochromocytoma and extra-adrenal PGL.

  4. Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.

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    Jennifer K Lowe

    2009-02-01

    Full Text Available It has been argued that the limited genetic diversity and reduced allelic heterogeneity observed in isolated founder populations facilitates discovery of loci contributing to both Mendelian and complex disease. A strong founder effect, severe isolation, and substantial inbreeding have dramatically reduced genetic diversity in natives from the island of Kosrae, Federated States of Micronesia, who exhibit a high prevalence of obesity and other metabolic disorders. We hypothesized that genetic drift and possibly natural selection on Kosrae might have increased the frequency of previously rare genetic variants with relatively large effects, making these alleles readily detectable in genome-wide association analysis. However, mapping in large, inbred cohorts introduces analytic challenges, as extensive relatedness between subjects violates the assumptions of independence upon which traditional association test statistics are based. We performed genome-wide association analysis for 15 quantitative traits in 2,906 members of the Kosrae population, using novel approaches to manage the extreme relatedness in the sample. As positive controls, we observe association to known loci for plasma cholesterol, triglycerides, and C-reactive protein and to a compelling candidate loci for thyroid stimulating hormone and fasting plasma glucose. We show that our study is well powered to detect common alleles explaining >/=5% phenotypic variance. However, no such large effects were observed with genome-wide significance, arguing that even in such a severely inbred population, common alleles typically have modest effects. Finally, we show that a majority of common variants discovered in Caucasians have indistinguishable effect sizes on Kosrae, despite the major differences in population genetics and environment.

  5. Mitochondrial Genome Diversity of Native Americans Supports a Single Early Entry of Founder Populations into America

    Science.gov (United States)

    Silva Jr., Wilson A.; Bonatto, Sandro L.; Holanda, Adriano J.; Ribeiro-dos-Santos, Andrea K.; Paixão, Beatriz M.; Goldman, Gustavo H.; Abe-Sandes, Kiyoko; Rodriguez-Delfin, Luis; Barbosa, Marcela; Paçó-Larson, Maria Luiza; Petzl-Erler, Maria Luiza; Valente, Valeria; Santos, Sidney E. B.; Zago, Marco A.

    2002-01-01

    There is general agreement that the Native American founder populations migrated from Asia into America through Beringia sometime during the Pleistocene, but the hypotheses concerning the ages and the number of these migrations and the size of the ancestral populations are surrounded by controversy. DNA sequence variations of several regions of the genome of Native Americans, especially in the mitochondrial DNA (mtDNA) control region, have been studied as a tool to help answer these questions. However, the small number of nucleotides studied and the nonclocklike rate of mtDNA control-region evolution impose several limitations to these results. Here we provide the sequence analysis of a continuous region of 8.8 kb of the mtDNA outside the D-loop for 40 individuals, 30 of whom are Native Americans whose mtDNA belongs to the four founder haplogroups. Haplogroups A, B, and C form monophyletic clades, but the five haplogroup D sequences have unstable positions and usually do not group together. The high degree of similarity in the nucleotide diversity and time of differentiation (i.e., ∼21,000 years before present) of these four haplogroups support a common origin for these sequences and suggest that the populations who harbor them may also have a common history. Additional evidence supports the idea that this age of differentiation coincides with the process of colonization of the New World and supports the hypothesis of a single and early entry of the ancestral Asian population into the Americas. PMID:12022039

  6. Congenital sucrase-isomaltase deficiency: identification of a common Inuit founder mutation.

    Science.gov (United States)

    Marcadier, Julien L; Boland, Margaret; Scott, C Ronald; Issa, Kheirie; Wu, Zaining; McIntyre, Adam D; Hegele, Robert A; Geraghty, Michael T; Lines, Matthew A

    2015-02-03

    Congenital sucrase-isomaltase deficiency is a rare hereditary cause of chronic diarrhea in children. People with this condition lack the intestinal brush-border enzyme required for digestion of di- and oligosaccharides, including sucrose and isomaltose, leading to malabsorption. Although the condition is known to be highly prevalent (about 5%-10%) in several Inuit populations, the genetic basis for this has not been described. We sought to identify a common mutation for congenital sucrase-isomaltase deficiency in the Inuit population. We sequenced the sucrase-isomaltase gene, SI, in a single Inuit proband with congenital sucrase-isomaltase deficiency who had severe fermentative diarrhea and failure to thrive. We then genotyped a further 128 anonymized Inuit controls from a variety of locales in the Canadian Arctic to assess for a possible founder effect. In the proband, we identified a novel, homozygous frameshift mutation, c.273_274delAG (p.Gly92Leufs*8), predicted to result in complete absence of a functional protein product. This change was very common among the Inuit controls, with an observed allele frequency of 17.2% (95% confidence interval [CI] 12.6%-21.8%). The predicted Hardy-Weinberg prevalence of congenital sucrase-isomaltase deficiency in Inuit people, based on this single founder allele, is 3.0% (95% CI 1.4%-4.5%), which is comparable with previous estimates. We found a common mutation, SI c.273_274delAG, to be responsible for the high prevalence of congenital sucrase-isomaltase deficiency among Inuit people. Targeted mutation testing for this allele should afford a simple and minimally invasive means of diagnosing this condition in Inuit patients with chronic diarrhea. © 2015 Canadian Medical Association or its licensors.

  7. A genetic cluster of patients with variant xeroderma pigmentosum with two different founder mutations.

    Science.gov (United States)

    Munford, V; Castro, L P; Souto, R; Lerner, L K; Vilar, J B; Quayle, C; Asif, H; Schuch, A P; de Souza, T A; Ienne, S; Alves, F I A; Moura, L M S; Galante, P A F; Camargo, A A; Liboredo, R; Pena, S D J; Sarasin, A; Chaibub, S C; Menck, C F M

    2017-05-01

    Xeroderma pigmentosum (XP) is a rare human syndrome associated with hypersensitivity to sunlight and a high frequency of skin tumours at an early age. We identified a community in the state of Goias (central Brazil), a sunny and tropical region, with a high incidence of XP (17 patients among approximately 1000 inhabitants). To identify gene mutations in the affected community and map the distribution of the affected alleles, correlating the mutations with clinical phenotypes. Functional analyses of DNA repair capacity and cell-cycle responses after ultraviolet exposure were investigated in cells from local patients with XP, allowing the identification of the mutated gene, which was then sequenced to locate the mutations. A specific assay was designed for mapping the distribution of these mutations in the community. Skin primary fibroblasts showed normal DNA damage removal but abnormal DNA synthesis after ultraviolet irradiation and deficient expression of the Polη protein, which is encoded by POLH. We detected two different POLH mutations: one at the splice donor site of intron 6 (c.764 +1 G>A), and the other in exon 8 (c.907 C>T, p.Arg303X). The mutation at intron 6 is novel, whereas the mutation at exon 8 has been previously described in Europe. Thus, these mutations were likely brought to the community long ago, suggesting two founder effects for this rare disease. This work describes a genetic cluster involving POLH, and, particularly unexpected, with two independent founder mutations, including one that likely originated in Europe. © 2016 British Association of Dermatologists.

  8. TGfU--Would You Know It if You Saw It? Benchmarks from the Tacit Knowledge of the Founders

    Science.gov (United States)

    Butler, Joy

    2014-01-01

    This paper explores the tacit expert knowledge and understanding about games curriculum and pedagogy of three men, Len Almond, David Bunker, and Rod Thorpe, credited as the founders of the Teaching Games for Understanding (TGfU) model. The model emerged from teacher practice in the late 1970s and was little theorized at the time, apart from a…

  9. Apple founder targets healthcare as NeXT market. Interview by Carolyn Dunbar and Michael L. Laughlin.

    Science.gov (United States)

    Jobs, S

    1992-12-01

    Cofounder and former chairman of the board of Apple Computer Steven Jobs looks beyond the 1980s image of a petulant, embittered young man, fighting with all who failed to share his vision, and many who did. Today, as a founder, president and chairman of NeXT, Inc., he looks to more high-minded applications of his computer genius.

  10. Elon Musk, founder of SpaceX and PayPal, to speak on campus Feb. 21

    OpenAIRE

    Crumbley, Liz

    2006-01-01

    Elon Musk, founder and chief executive officer of Space Exploration Technologies Co. (SpaceX), will speak on his company's Falcon rocket series and the future of university space research on Tuesday, Feb. 21 at 7:30 p.m. in Virginia Tech's Burruss Hall Auditorium. The event is free and open to the public.

  11. Valimissüsteemi tuleks muuta / Rein Taagepera

    Index Scriptorium Estoniae

    Taagepera, Rein, 1933-

    2007-01-01

    Autor on seisukohal, et praegune Riigikogu valimise süsteem on liiga keeruline ja seda tuleks lihtsustada. Ta vaatleb, mis juhtuks siis, kui Eesti oleks jagatud 101 valimisringkonnaks, kus enim hääli saanud kandidaat võidab, või kui Eesti oleks üksainus valimispiirkond, kus 101 enim hääli saanud kandidaati võidavad

  12. Peaks Venemaa tükeldama / Rein Taagepera

    Index Scriptorium Estoniae

    Taagepera, Rein, 1933-

    2001-01-01

    Ettekanne "Should Russia Break Up" Ameerika Politoloogia Ühingu aastakoosolekul Washingtonis 3.septembril 2000.a. Venemaa majanduslik ja poliitiline olukord seoses kolme revolutsiooni toimumisega: demokratiseerimine, turumajanduse sissetoomine ning dekoloniseerimine. Venemaa territoriaalse arengu võimalused

  13. Org-1 is required for the diversification of circular visceral muscle founder cells and normal midgut morphogenesis.

    Science.gov (United States)

    Schaub, Christoph; Frasch, Manfred

    2013-04-15

    The T-Box family of transcription factors plays fundamental roles in the generation of appropriate spatial and temporal gene expression profiles during cellular differentiation and organogenesis in animals. In this study we report that the Drosophila Tbx1 orthologue optomotor-blind-related-gene-1 (org-1) exerts a pivotal function in the diversification of circular visceral muscle founder cell identities in Drosophila. In embryos mutant for org-1, the specification of the midgut musculature per se is not affected, but the differentiating midgut fails to form the anterior and central midgut constrictions and lacks the gastric caeca. We demonstrate that this phenotype results from the nearly complete loss of the founder cell specific expression domains of several genes known to regulate midgut morphogenesis, including odd-paired (opa), teashirt (tsh), Ultrabithorax (Ubx), decapentaplegic (dpp) and wingless (wg). To address the mechanisms that mediate the regulatory inputs from org-1 towards Ubx, dpp, and wg in these founder cells we genetically dissected known visceral mesoderm specific cis-regulatory-modules (CRMs) of these genes. The analyses revealed that the activities of the dpp and wg CRMs depend on org-1, the CRMs are bound by Org-1 in vivo and their T-Box binding sites are essential for their activation in the visceral muscle founder cells. We conclude that Org-1 acts within a well-defined signaling and transcriptional network of the trunk visceral mesoderm as a crucial founder cell-specific competence factor, in concert with the general visceral mesodermal factor Biniou. As such, it directly regulates several key genes involved in the establishment of morphogenetic centers along the anteroposterior axis of the visceral mesoderm, which subsequently organize the formation of midgut constrictions and gastric caeca and thereby determine the morphology of the midgut. Copyright © 2013 Elsevier Inc. All rights reserved.

  14. Etica publica & buen gobierno

    Directory of Open Access Journals (Sweden)

    Manjarrez, J.

    2007-01-01

    Full Text Available Modern societies demand governments promoting equitable and sustainable development and combating corruption. In the different areas of the public administration, factors such as transparency, efficiency, effectiveness, accountability, economy, human rights and respect to the legal framework are of great relevance for a good government. In Mexico it is necessary to reinforce the ethical aspect in the public administration to diminish the level of corruption. The ethical behavior of the public servant is related to integrity, honesty, transparency, expertise and leadership, it is part of the social capital of a country and a necessary condition to a good government and to eradicate corruption. It is essential to establish efficient systems, programs and mechanisms to promote the importance of ethics in government and society. Finally, society must vote to punish or reward the government performance, recognize its social duties and rights, demand the equal exercise of the law and always act ethically.

  15. O metifenidato no Brasil: uma década de publicações Methylphenidate in Brazil: a decade of publications

    Directory of Open Access Journals (Sweden)

    Francisco Ortega

    2013-03-01

    Full Text Available O metilfenidato é um estimulante comercializado desde os anos 50 na Suíça, na Alemanha e nos EUA. Mas foi somente a partir de sua associação com o Transtorno do Déficit de Atenção e Hiperatividade (TDAH que suas vendas alavancaram, tornando-se o estimulante mais consumido no mundo. Este artigo tem por objetivo apresentar os resultados de uma análise das publicações brasileiras sobre os usos do metilfenidato no Brasil, ao longo da última década. Com isto, visa compreender como as informações são apresentadas ou omitidas nos diferentes espaços de divulgação impressa. Para tal análise, foram pesquisadas publicações científicas, nos principais periódicos de psiquiatria brasileiros, e reportagens de jornais e revistas nacionais destinados ao público em geral. A pesquisa inclui as publicações do período de 1998 a 2008. Destaca-se como ponto relevante da análise a importante participação dos laboratórios no financiamento dos grupos e pesquisas sobre TDAH. Os achados indicam que a combinação do uso do medicamento com psicoterapias, a dependência do medicamento e a ideia de que existe excesso de prescrição no Brasil são temas controversos nas publicações analisadas.Methylphenidate is frequently associated with Attention Deficit Hyperactivity disorder (ADHD, though this psychostimulant has been on the market in Switzerland, Germany and the US since the 1950s. After its association with ADHD, Ritalin has become the world's most widely used psychostimulant. The scope of this article is to present the results of an analysis of publications concerning the use of Methylphenidate in Brazil over a decade. It seeks to understand how the information is presented or omitted in the different printed materials. For the analysis, the most important Brazilian psychiatric journals as well as major Brazilian newspapers and magazines for the general public for the 1998-2008 period were consulted. One important point that resulted

  16. Highly prevalent LIPH founder mutations causing autosomal recessive woolly hair/hypotrichosis in Japan and the genotype/phenotype correlations.

    Directory of Open Access Journals (Sweden)

    Kana Tanahashi

    Full Text Available Mutations in LIPH cause of autosomal recessive woolly hair/hypotrichosis (ARWH, and the 2 missense mutations c.736T>A (p.Cys246Ser and c.742C>A (p.His248Asn are considered prevalent founder mutations for ARWH in the Japanese population. To reveal genotype/phenotype correlations in ARWH cases in Japan and the haplotypes in 14 Japanese patients from 14 unrelated Japanese families. 13 patients had woolly hair, and 1 patient had complete baldness since birth. An LIPH mutation search revealed homozygous c.736T>A mutations in 10 of the patients. Compound heterozygous c.736T>A and c.742C>A mutations were found in 3 of the patients, and homozygous c.742C>A mutation in 1 patient. The phenotype of mild hypotrichosis with woolly hair was restricted to the patients with the homozygous c.736T>A mutation. The severe phenotype of complete baldness was seen in only 1 patient with homozygous c.742C>A. Haplotype analysis revealed that the alleles containing the LIPH c.736T>A mutation had a haplotype identical to that reported previously, although 4 alleles out of 5 chromosomes containing the LIPH c.742C>A mutation had a different haplotype from the previously reported founder allele. These alleles with c.742C>A are thought to be the third founder LIPH mutation causing ARWH. To accurately determine the prevalence of the founder mutations, we investigated allele frequencies of those mutations in 819 Japanese controls. Heterozygous c.736T>A mutations were found in 13 controls (allele frequency: 0.0079; carrier rate: 0.016, and heterozygous c.742C>A mutations were found in 2 controls (allele frequency: 0.0012; carrier rate: 0.0024. In conclusion, this study confirms the more accurate allele frequencies of the pathogenic founder mutations of LIPH and shows that there is a third founder mutation in Japan. In addition, the present findings suggest that the mutation patterns of LIPH might be associated with hypotrichosis severity in ARWH.

  17. Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus

    Science.gov (United States)

    Liao, Hua-Xin; Lynch, Rebecca; Zhou, Tongqing; Gao, Feng; Alam, S. Munir; Boyd, Scott D.; Fire, Andrew Z.; Roskin, Krishna M.; Schramm, Chaim A.; Zhang, Zhenhai; Zhu, Jiang; Shapiro, Lawrence; Mullikin, James C.; Gnanakaran, S.; Hraber, Peter; Wiehe, Kevin; Kelsoe, Garnett; Yang, Guang; Xia, Shi-Mao; Montefiori, David C.; Parks, Robert; Lloyd, Krissey E.; Scearce, Richard M.; Soderberg, Kelly A.; Cohen, Myron; Kaminga, Gift; Louder, Mark K.; Tran, Lillan M.; Chen, Yue; Cai, Fangping; Chen, Sheri; Moquin, Stephanie; Du, Xiulian; Joyce, Gordon M.; Srivatsan, Sanjay; Zhang, Baoshan; Zheng, Anqi; Shaw, George M.; Hahn, Beatrice H.; Kepler, Thomas B.; Korber, Bette T.M.; Kwong, Peter D.; Mascola, John R.; Haynes, Barton F.

    2013-01-01

    Current HIV-1 vaccines elicit strain-specific neutralizing antibodies. However, cross-reactive neutralizing antibodies arise in ~20% of HIV-1-infected individuals, and details of their generation could provide a roadmap for effective vaccination. Here we report the isolation, evolution and structure of a broadly neutralizing antibody from an African donor followed from time of infection. The mature antibody, CH103, neutralized ~55% of HIV-1 isolates, and its co-crystal structure with gp120 revealed a novel loop-based mechanism of CD4-binding site recognition. Virus and antibody gene sequencing revealed concomitant virus evolution and antibody maturation. Notably, the CH103-lineage unmutated common ancestor avidly bound the transmitted/founder HIV-1 envelope glycoprotein, and evolution of antibody neutralization breadth was preceded by extensive viral diversification in and near the CH103 epitope. These data elucidate the viral and antibody evolution leading to induction of a lineage of HIV-1 broadly neutralizing antibodies and provide insights into strategies to elicit similar antibodies via vaccination. PMID:23552890

  18. Nukuleka as a founder colony for West Polynesian settlement : new insights from recent excavations

    International Nuclear Information System (INIS)

    Burley, D.V.; Barton, A.; Dickinson, W.R.; Connaughton, S.P.; Tache, K.

    2010-01-01

    Previous archaeological studies in the village of Nukuleka, Tongatapu, Kingdom of Tonga proposed it as a founder colony for Polynesia. Additional excavation and survey were undertaken in 2007 to evaluate this status further and to gain new insight into the nature of the occupation and its role in the subsequent peopling of west Polynesia. A review of this project and its findings are presented. Decorated ceramics of western Lapita style, the presence of tan paste ceramics foreign to Tonga, and new radiocarbon dates support Nukuleka as a site of first landfall in the interval 2850 to 2900 cal BP. The ceramic assemblage is distinct from west and central Fiji, and an independent origin for Fijian and Polynesian colonizers is argued. The settlement quickly expanded on the Nukuleka Peninsula to 20 ha or more in size, forming a central place for the eastern Lapita province in Tonga, Samoa and the Lau islands of Fiji. Nukuleka, we believe, provides insight into the cultural if not biological base from which ancestral Polynesian society emerged. (author). 35 refs., 11 figs., 3 tabs.

  19. Founder Fukutin mutation causes Walker-Warburg syndrome in four Ashkenazi Jewish families.

    Science.gov (United States)

    Chang, Wendy; Winder, Thomas L; LeDuc, Charles A; Simpson, Lynn L; Millar, William S; Dungan, Jeffrey; Ginsberg, Norman; Plaga, Stacey; Moore, Steven A; Chung, Wendy K

    2009-06-01

    Walker-Warburg syndrome (WWS) is a genetically heterogeneous congenital muscular dystrophy caused by abnormal glycosylation of alpha-dystroglycan (alpha-DG) that is associated with brain malformations and eye anomalies. The Fukutin (FKTN) gene, which causes autosomal recessively inherited WWS is most often associated with Fukuyama congenital muscular dystrophy in Japan. We describe the clinical features of four nonconsanguinous Ashkenazi Jewish families with WWS and identify the underlying genetic basis for WWS. We screened for mutations in POMGnT1, POMT1, POMT2, and FKTN, genes causing WWS, by dideoxy sequence analysis. We identified an identical homozygous c.1167insA mutation in the FKTN gene on a common haplotype in all four families and identified 2/299 (0.7%) carriers for the c.1167insA mutation among normal American Ashkenazi Jewish adults. These data suggest that the c.1167insA FKTN mutation described by us is a founder mutation that can be used to target diagnostic testing and carrier screening in the Ashkenazi Jewish population. Copyright (c) 2009 John Wiley & Sons, Ltd.

  20. Founder Fukutin mutation causes Walker-Warburg syndrome in four Ashkenazi Jewish families†

    Science.gov (United States)

    Chang, Wendy; Winder, Thomas L.; LeDuc, Charles A.; Simpson, Lynn L.; Millar, William S.; Dungan, Jeffrey; Ginsberg, Norman; Plaga, Stacey; Moore, Steven A.; Chung, Wendy K.

    2009-01-01

    Objective Walker-Warburg syndrome (WWS) is a genetically heterogeneous congenital muscular dystrophy caused by abnormal glycosylation of α-dystroglycan (α-DG) that is associated with brain malformations and eye anomalies. The Fukutin (FKTN) gene, which causes autosomal recessively inherited WWS is most often associated with Fukuyama congenital muscular dystrophy in Japan. We describe the clinical features of four nonconsanguinous Ashkenazi Jewish families with WWS and identify the underlying genetic basis for WWS. Method We screened for mutations in POMGnT1, POMT1, POMT2, and FKTN, genes causing WWS, by dideoxy sequence analysis. Results We identified an identical homozygous c.1167insA mutation in the FKTN gene on a common haplotype in all four families and identified 2/299 (0.7%) carriers for the c.1167insA mutation among normal American Ashkenazi Jewish adults. Conclusion These data suggest that the c.1167insA FKTN mutation described by us is a founder mutation that can be used to target diagnostic testing and carrier screening in the Ashkenazi Jewish population. PMID:19266496

  1. Use of Dried Blood Spots to Elucidate Full-Length Transmitted/Founder HIV-1 Genomes

    Directory of Open Access Journals (Sweden)

    Jesus F. Salazar-Gonzalez

    2016-07-01

    Full Text Available Background: Identification of HIV-1 genomes responsible for establishing clinical infection in newly infected individuals is fundamental to prevention and pathogenesis research. Processing, storage, and transportation of the clinical samples required to perform these virologic assays in resource-limited settings requires challenging venipuncture and cold chain logistics. Here, we validate the use of dried-blood spots (DBS as a simple and convenient alternative to collecting and storing frozen plasma. Methods: We performed parallel nucleic acid extraction, single genome amplification (SGA, next generation sequencing (NGS, and phylogenetic analyses on plasma and DBS. Results: We demonstrated the capacity to extract viral RNA from DBS and perform SGA to infer the complete nucleotide sequence of the transmitted/founder (TF HIV-1 envelope gene and full-length genome in two acutely infected individuals. Using both SGA and NGS methodologies, we showed that sequences generated from DBS and plasma display comparable phylogenetic patterns in both acute and chronic infection. SGA was successful on samples with a range of plasma viremia, including samples as low as 1,700 copies/ml and an estimated ~50 viral copies per blood spot. Further, we demonstrated reproducible efficiency in gp160 env sequencing in DBS stored at ambient temperature for up to three weeks or at -20ºC for up to five months. Conclusions: These findings support the use of DBS as a practical and cost-effective alternative to frozen plasma for clinical trials and translational research conducted in resource-limited settings.

  2. Willet M. Hays, great benefactor to plant breeding and the founder of our association.

    Science.gov (United States)

    Troyer, A F; Stoehr, H

    2003-01-01

    Willet M. Hays was a great benefactor to plant breeding and the founder of the American Genetic Association (AGA). We commemorate the AGA's centennial. We mined university archives, U.S. Department of Agriculture (USDA) yearbooks, plant breeding textbooks, scientific periodicals, and descendants for information. Willet Hays first recognized the individual plant as the unit of selection and started systematic pure-line selection and progeny tests in 1888. He developed useful plant breeding methods. He selected superior flax (Linum usitatissimum L.), wheat (Triticum vulgare L.), corn (Zea mays L.), barley (Hordeum vulgare L.), and oat (Avena sativa L.) varieties, and discovered Grimm alfalfa (Medicago sativa L.); all became commercially important. He initiated branch stations for better performance testing. Willet Hays befriended colleagues in other universities, in federal stations, in a London conference, and in Europe. He gathered and spread the scientific plant breeding gospel. He also improved rural roads and initiated animal breeding records and agricultural economics records. He started the AGA in 1903, serving as secretary for 10 years. He became assistant secretary of agriculture in 1904. He introduced the project system for agricultural research. He authored or coauthored the Nelson Amendment, the Smith-Lever Act, the Smith-Hughes Act, and the protocol leading to the United Nations Food and Agriculture Organization-all involved teaching agricultural practices that improved the world.

  3. A serial founder effect model for human settlement out of Africa.

    Science.gov (United States)

    Deshpande, Omkar; Batzoglou, Serafim; Feldman, Marcus W; Cavalli-Sforza, L Luca

    2009-01-22

    The increasing abundance of human genetic data has shown that the geographical patterns of worldwide genetic diversity are best explained by human expansion out of Africa. This expansion is modelled well by prolonged migration from a single origin in Africa with multiple subsequent serial founding events. We discuss a new simulation model for the serial founder effect out of Africa and compare it with results from previous studies. Unlike previous models, we distinguish colonization events from the continued exchange of people between occupied territories as a result of mating. We conduct a search through parameter space to estimate the range of parameter values that best explain key statistics from published data on worldwide variation in microsatellites. The range of parameters we use is chosen to be compatible with an out-of-Africa migration at 50-60Kyr ago and archaeo-ethno-demographic information. In addition to a colonization rate of 0.09-0.18, for an acceptable fit to the published microsatellite data, incorporation into existing models of exchange between neighbouring populations is essential, but at a very low rate. A linear decay of genetic diversity with geographical distance from the origin of expansion could apply to any species, especially if it moved recently into new geographical niches.

  4. Founder effect of a prevalent phenylketonuria mutation in the Oriental population

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Tao (Baylor College of Medicine, Houston, TX (United States) Chinese Academy of Medical Sciences, Beijing (China)); Okano, Yoshiyuki; Eisensmith, R.C.; Harvey, M.L.; Woo, S.L.C. (Baylor College of Medicine, Houston, TX (United States)); Lo, W.H.Y.; Yuan, Lifang (Chinese Academy of Medical Sciences, Beijing (China)); Huang, Shuzhen; Zeng, Yitao (Shanghai Children' s Hospital (China)); Furuyama, Junichi (Hyogo College of Medicine, Nishinomiya (Japan)); Oura, Toshiaki (Osaka Municipal Rehabilitation Center for the Disabled, Osaka (Japan)); Sommer, S.S. (Mayo Clinic/Foundation, Rochester, MN (United States))

    1991-03-15

    A missense mutation has been identified in the human phenylalanine hydroxylase Chinese patient with classic phenylketonuria (PKU). A G-to-C transition at the second base of codon 413 in exon 12 of the gene results in the substitution of Pro{sup 413} for Arg{sup 413} in the mutant protein. This mutation (R413P) results in negligible enzymatic activity when expressed in heterologous mammalian cells and is compatible with a classic PKU phenotype in the patient. Population genetic studies reveal that this mutation is tightly linked to restriction fragment length polymorphism haplotype 4, which is the predominant haplotype of the PAH locus in the Oriental population. It accounts for 13.8% of northern Chinese and 27% of Japanese PKU alleles, but it is rare in southern Chinese (2.2%) and is absent in the Caucasian population. The data demonstrate unambiguously that the mutation occurred after racial divergence of Orientals and Caucasians and suggest that the allele has spread throughout the Orient by a founder effect. Previous protein polymorphism studies in eastern Asia have led to the hypothesis that northern Mongoloids represented a founding population in Asia. The results are compatible with this hypothesis in that the PKU mutation might have occurred in northern Mongoloids and subsequently spread to the Chinese and Japanese populations.

  5. Founder effect of a prevalent phenylketonuria mutation in the Oriental population

    International Nuclear Information System (INIS)

    Wang, Tao; Okano, Yoshiyuki; Eisensmith, R.C.; Harvey, M.L.; Woo, S.L.C.; Lo, W.H.Y.; Yuan, Lifang; Huang, Shuzhen; Zeng, Yitao; Furuyama, Junichi; Oura, Toshiaki; Sommer, S.S.

    1991-01-01

    A missense mutation has been identified in the human phenylalanine hydroxylase Chinese patient with classic phenylketonuria (PKU). A G-to-C transition at the second base of codon 413 in exon 12 of the gene results in the substitution of Pro 413 for Arg 413 in the mutant protein. This mutation (R413P) results in negligible enzymatic activity when expressed in heterologous mammalian cells and is compatible with a classic PKU phenotype in the patient. Population genetic studies reveal that this mutation is tightly linked to restriction fragment length polymorphism haplotype 4, which is the predominant haplotype of the PAH locus in the Oriental population. It accounts for 13.8% of northern Chinese and 27% of Japanese PKU alleles, but it is rare in southern Chinese (2.2%) and is absent in the Caucasian population. The data demonstrate unambiguously that the mutation occurred after racial divergence of Orientals and Caucasians and suggest that the allele has spread throughout the Orient by a founder effect. Previous protein polymorphism studies in eastern Asia have led to the hypothesis that northern Mongoloids represented a founding population in Asia. The results are compatible with this hypothesis in that the PKU mutation might have occurred in northern Mongoloids and subsequently spread to the Chinese and Japanese populations

  6. Academician L. V. Pisarzhevsky is the founder of chemical science and education in Dnipropetrovsk university

    Directory of Open Access Journals (Sweden)

    Valerij S. Kovalenko

    2014-12-01

    Full Text Available The article is devoted to the 140 anniversary of birth of the academician Lev Vladimirovich Pisarzhevsky, who was a distinguished chemical scientist, founder of the important area of chemical science – electronic chemistry. The article dwells upon the basic stages of the scientist’s life and creative art. The major results of scientific and educational activity during Dnipropetrovsk period of his life are reported. His role in the foundation of dnipropetrovsk scientific school of physical chemistry, as well as in its establishment, is shown. The pioneering role of the academician L. V. Pisarzhevsky in the formation of the theory of redox reactions as processes of returning and joining of electrons, which is generally accepted nowadays, as well as in the creation of backgrounds of modern electronic theories of catalysis, has been shown. L. V. Pisarzhevsky is characterized as a wonderful lecturer and teacher who expounded chemical material from the point of view of electronic conception and laid the foundation for the reformation of chemistry. The role of the academician L. V. Pisarzhevsky in the foundation of Dnipropetrovsk University and its chemical department, as well as in the organization of educational process in this establishment, is exposed using archive materials, which are kept in the funds of the State Archive of the Dnipropetrovsk region and of the historical museum of Oles Honchar Dnipropetrovsk National University.

  7. A Mayan founder mutation is a common cause of deafness in Guatemala.

    Science.gov (United States)

    Carranza, C; Menendez, I; Herrera, M; Castellanos, P; Amado, C; Maldonado, F; Rosales, L; Escobar, N; Guerra, M; Alvarez, D; Foster, J; Guo, S; Blanton, S H; Bademci, G; Tekin, M

    2015-09-08

    Over 5% of the world's population has varying degrees of hearing loss. Mutations in GJB2 are the most common cause of autosomal recessive non-syndromic hearing loss (ARNHL) in many populations. The frequency and type of mutations are influenced by ethnicity. Guatemala is a multi-ethnic country with four major populations: Maya, Ladino, Xinca, and Garifuna. To determine the mutation profile of GJB2 in a ARNHL population from Guatemala, we sequenced both exons of GJB2 in 133 unrelated families. A total of six pathogenic variants were detected. The most frequent pathogenic variant is c.131G>A (p.Trp44*) detected in 21 of 266 alleles. We show that c.131G>A is associated with a conserved haplotype in Guatemala suggesting a single founder. The majority of Mayan population lives in the west region of the country from where all c.131G>A carriers originated. Further analysis of genome-wide variation of individuals carrying the c.131G>A mutation compared with those of Native American, European, and African populations shows a close match with the Mayan population. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  8. [HUGO STEINHAUS--CO-FOUNDER OF THE LWÓW SCHOOL OF MATHEMATICS].

    Science.gov (United States)

    Wócik, Wiesław

    2014-01-01

    The paper is dedicated to the presentation of professor Hugo Steinhaus--co-founder of the Lwów School of Mathematics. It is indicated that had it not been for the scholar, the founding and development of the Lwów School of Mathematics would have been almost impossible. The analyses focus on his undertakings during the Lvov period in the early 1920s and those events that preceded the founding of the school (namely Steinhaus's education at the Göttingen University, various meetings and gatherings, discussions, first fascinations and mathematical dissertations). This paper, however, does not look into the scientific output of Steinhaus, only presents his method of scientific work and highlights the strategy that he chose in order to create the scientific community. An attempt has been also made to justify the effectiveness of the adopted strategy by describing the scientific atmosphere of Lvov and intellectual potential of the students of the school. Steinhaus's activities in the 1930s will be only marginally presented with an impact on particularly interesting cooperation with the alumni of the Lwów School of Mathematics--Marek Kac, Stefan Kaczmarz, Paweł Nikliborec and scholars from other fields of science (as part of the process of the application of mathematics).

  9. Isolation mediates persistent founder effects on zooplankton colonisation in new temporary ponds

    Science.gov (United States)

    Badosa, Anna; Frisch, Dagmar; Green, Andy J.; Rico, Ciro; Gómez, Africa

    2017-03-01

    Understanding the colonisation process in zooplankton is crucial for successful restoration of aquatic ecosystems. Here, we analyzed the clonal and genetic structure of the cyclical parthenogenetic rotifer Brachionus plicatilis by following populations established in new temporary ponds during the first three hydroperiods. Rotifer populations established rapidly after first flooding, although colonisation was ongoing throughout the study. Multilocus genotypes from 7 microsatellite loci suggested that most populations (10 of 14) were founded by few clones. The exception was one of the four populations that persisted throughout the studied hydroperiods, where high genetic diversity in the first hydroperiod suggested colonisation from a historical egg bank, and no increase in allelic diversity was detected with time. In contrast, in another of these four populations, we observed a progressive increase of allelic diversity. This population became less differentiated from the other populations suggesting effective gene flow soon after its foundation. Allelic diversity and richness remained low in the remaining two, more isolated, populations, suggesting little gene flow. Our results highlight the complexity of colonisation dynamics, with evidence for persistent founder effects in some ponds, but not in others, and with early immigration both from external source populations, and from residual, historical diapausing egg banks.

  10. Genome-wide association study of pre-harvest sprouting resistance in Chinese wheat founder parents

    Directory of Open Access Journals (Sweden)

    Yu Lin

    2017-07-01

    Full Text Available Abstract Pre-harvest sprouting (PHS is a major abiotic factor affecting grain weight and quality, and is caused by an early break in seed dormancy. Association mapping (AM is used to detect correlations between phenotypes and genotypes based on linkage disequilibrium (LD in wheat breeding programs. We evaluated seed dormancy in 80 Chinese wheat founder parents in five environments and performed a genome-wide association study using 6,057 markers, including 93 simple sequence repeat (SSR, 1,472 diversity array technology (DArT, and 4,492 single nucleotide polymorphism (SNP markers. The general linear model (GLM and the mixed linear model (MLM were used in this study, and two significant markers (tPt-7980 and wPt-6457 were identified. Both markers were located on Chromosome 1B, with wPt-6457 having been identified in a previously reported chromosomal position. The significantly associated loci contain essential information for cloning genes related to resistance to PHS and can be used in wheat breeding programs.

  11. Founders Energy Ltd. 1998 annual report : fiscally prudent, value driven balanced growth strategy

    International Nuclear Information System (INIS)

    1999-01-01

    Founders Energy Ltd is a growth-oriented junior resource company engaged in the acquisition and development of oil and natural gas properties in Alberta, British Columbia and Saskatchewan. The annual review provides details of the company's operations and relevant financial performance during the 1998 fiscal year. In brief, the company realized significant increases in production and reserves, top quartile findings and development costs. It reported significant increases in leverage to natural gas through exploration success at Pouce Coupe and the acquisition of Opal Energy Inc.. It established new core areas in west-central Alberta, Peace River Arch and west-central Saskatchewan. It achieved a better balanced risk profile through geographical diversification and better balance to exploration and development. It increased undeveloped land area to 160,268 net acres and added 11.5 million barrels of established reserves at a finding cost of $ 6.28 per barrel. Financial highlights include increased gross revenue, increased net income per share, and increased shareholders' equity. tabs., figs

  12. Density of founder cells affects spatial pattern formation and cooperation in Bacillus subtilis biofilms.

    Science.gov (United States)

    van Gestel, Jordi; Weissing, Franz J; Kuipers, Oscar P; Kovács, Akos T

    2014-10-01

    In nature, most bacteria live in surface-attached sedentary communities known as biofilms. Biofilms are often studied with respect to bacterial interactions. Many cells inhabiting biofilms are assumed to express 'cooperative traits', like the secretion of extracellular polysaccharides (EPS). These traits can enhance biofilm-related properties, such as stress resilience or colony expansion, while being costly to the cells that express them. In well-mixed populations cooperation is difficult to achieve, because non-cooperative individuals can reap the benefits of cooperation without having to pay the costs. The physical process of biofilm growth can, however, result in the spatial segregation of cooperative from non-cooperative individuals. This segregation can prevent non-cooperative cells from exploiting cooperative neighbors. Here we examine the interaction between spatial pattern formation and cooperation in Bacillus subtilis biofilms. We show, experimentally and by mathematical modeling, that the density of cells at the onset of biofilm growth affects pattern formation during biofilm growth. At low initial cell densities, co-cultured strains strongly segregate in space, whereas spatial segregation does not occur at high initial cell densities. As a consequence, EPS-producing cells have a competitive advantage over non-cooperative mutants when biofilms are initiated at a low density of founder cells, whereas EPS-deficient cells have an advantage at high cell densities. These results underline the importance of spatial pattern formation for competition among bacterial strains and the evolution of microbial cooperation.

  13. [On the founders of the Institute of Mathematics and Physics, University of Bahia].

    Science.gov (United States)

    Dias, A L

    The reduced number of female students of mathematics at the University of Bahia School of Philosophy (Faculdade de Filosofia, Universidade da Bahia - FF/UBa) is quite surprising. To date, they are concentrated in areas traditionally viewed as feminine whereas men predominate in the mathematical fields. I have examined interview data from a few women who graduated in mathematics and went on to teach at the University of Bahia School of Mathematics (Faculdade de Filosofia - FF) and at the Institute of Mathematics and Physics (Instituto de Matemática e Física - IMF), where they were soon to outnumber men and constitute the majority of the mathematics teaching staff. In this study, I have investigated the course of their careers over time: from their early student days, through their time as teaching assistants and professors, and finally as founders of the Institute of Mathematics and Physics, in 1960. Special reference is made to Martha Maria de Souza Dantas, organizer of the I Brazilian Conference on Mathematics Teaching, an event which has provided the groundwork for what was to become the Institute (IMF); and to Arlete Cerqueira Lima, the mastermind behind its creation.

  14. Founder effect of the RET C611Y mutation in multiple endocrine neoplasia 2A in Denmark

    DEFF Research Database (Denmark)

    Mathiesen, Jes Sloth; Kroustrup, Jens Peter; Vestergaard, Peter

    2017-01-01

    BACKGROUND: Multiple endocrine neoplasia (MEN) 2A and 2B are caused by REarranged during Transfection (RET) germline mutations. In a recent nationwide study we reported of an unusually high prevalence (33%) of families with the C611Y mutation and hypothesized that this might be due to a founder...... effect. We conducted the first nationwide study of haplotypes in MEN2A families aiming to investigate the relatedness and occurrence of de novo mutations among Danish families carrying similar mutations. METHODS: The study included 21 apparently unrelated MEN2A families identified from a nationwide...... Danish RET cohort from 1994 to 2014. Twelve, two, two, three and two families carried the C611Y, C618F, C618Y, C620R and C634R mutation, respectively. Single nucleotide polymorphism chip data and identity by descent analysis were used to assess relatedness. RESULTS: A common founder mutation was found...

  15. Gerald J. Marks, M.D., FACS (1925-), founder of the Society of American Gastrointestinal Endoscopic Surgeons (SAGES).

    Science.gov (United States)

    Yeo, Theresa P; Cowan, Scott W; Yeo, Charles J

    2018-03-01

    This historical vignette describes the professional career of Gerald J. Marks, the founder of the Society of American Gastrointestinal and Endoscopic Surgeons and the International Federation of Societies of Endoscopic Surgeons. Dr. Marks is also the founding Associate Editor of Surgical Endoscopy, which celebrated its 30th anniversary in 2017. Dr. Marks is a renowned colorectal surgeon, an accomplished watercolor artist, and a fascinating personality.

  16. KT seminar on entrepreneurship | "From CERN engineer to company founder: my journey" by Julio Lucas | 26 September

    CERN Multimedia

    2016-01-01

    Europe needs its economy to be boosted by the ideas of its most talented scientists and engineers. One of the best ways in which these ideas may contribute to society is by creating a new business. In this Knowledge Transfer seminar, Julio Lucas, Technical Director and co-founder of Elytt Energy and former CERN engineer gives a personal view on how to make your first steps in entrepreneurship.    

  17. 13 February 2012 - World Economic Forum Founder and Executive Chairman K. Schwab and Chairperson and Co-Founder Schwab Foundation for Social Entrepreneurship H. Schwab (Mrs)in the ATLAS experimental area at LHC Point 1 with Collaboration Former Spokesperson P. Jenni; signing the guest book with CERN Director-General R. Heuer and Head of International Relations F. Pauss.

    CERN Multimedia

    Jean-Claude Gadmer

    2012-01-01

    13 February 2012 - World Economic Forum Founder and Executive Chairman K. Schwab and Chairperson and Co-Founder Schwab Foundation for Social Entrepreneurship H. Schwab (Mrs)in the ATLAS experimental area at LHC Point 1 with Collaboration Former Spokesperson P. Jenni; signing the guest book with CERN Director-General R. Heuer and Head of International Relations F. Pauss.

  18. Análisis de los factores que dieron emergencia y desarrollo a la política publica del salario mínimo en Colombia, 1934- 1945

    OpenAIRE

    González Mejía, Mariana

    2013-01-01

    Este trabajo de grado es una recopilación bibliográfica de múltiples factores nacionales e internacionales que pueden explicar la emergencia y desarrollo de la política publica del salario mínimo en Colombia. Todo esto esta cubierto bajo la definición de política publica de Raúl Velasquez. La relevancia del trabajo esta en que se hace el estudio de un fenómeno económico desde el lado social.

  19. A qualidade das publicações científicas: considerações de um Editor de Área ao final do mandato Quality of scientific puplications: considerations of an editor at the end of the mandate

    OpenAIRE

    Ulysses Paulino de Albuquerque

    2009-01-01

    A qualidade das publicações científicas vem sendo discutida na atualidade considerando diferentes perspectivas. Neste texto, examina-se alguns dos principais problemas relativos à produção textual em ciência, com ênfase para os considerados de má conduta. Adicionalmente, são apresentadas sugestões para autores, revisores e editores no sentido de evitar condutas inadequadas no processo de publicação de trabalhos científicos.Quality of scientific publications is being currently discussed consid...

  20. Quentin Skinner, Staten og friheten. Oslo: Res Publica, 2011. José Luis Martí and Philip Pettit, A Political Philosophy in Public Life. Civic Republicanism in Zapatero's Spain. Princeton: Princeton University Press, 2010 (Simon Laumann Jørgensen)

    DEFF Research Database (Denmark)

    Jørgensen, Simon Laumann

    2012-01-01

    Anmeldelse af Quentin Skinner, Staten og friheten, Oslo: Res Publica 2011, 199 NOK & José Luis Martí & Philip Pettit, A Political Philosophy in Public Life. Civic Republicanism in Zapatero’s Spain, Princeton: Princeton University Press 2010, $ 24.95......Anmeldelse af Quentin Skinner, Staten og friheten, Oslo: Res Publica 2011, 199 NOK & José Luis Martí & Philip Pettit, A Political Philosophy in Public Life. Civic Republicanism in Zapatero’s Spain, Princeton: Princeton University Press 2010, $ 24.95...

  1. Identification of full-length transmitted/founder viruses and their progeny in primary HIV-1 infection

    Energy Technology Data Exchange (ETDEWEB)

    Korber, Bette [Los Alamos National Laboratory; Hraber, Peter [Los Alamos National Laboratory; Giorgi, Elena [Los Alamos National Laboratory; Bhattacharya, T [Los Alamos National Laboratory

    2009-01-01

    Identification of transmitted/founder virus genomes and their progeny by is a novel strategy for probing the molecular basis of HIV-1 transmission and for evaluating the genetic imprint of viral and host factors that act to constrain or facilitate virus replication. Here, we show in a cohort of twelve acutely infected subjects (9 clade B; 3 clade C), that complete genomic sequences of transmitted/founder viruses could be inferred using single genome amplification of plasma viral RNA, direct amplicon sequencing, and a model of random virus evolution. This allowed for the precise identification, chemical synthesis, molecular cloning, and biological analysis of those viruses actually responsible for productive clinical infection and for a comprehensive mapping of sequential viral genomes and proteomes for mutations that are necessary or incidental to the establishment of HIV-1 persistence. Transmitted/founder viruses were CD4 and CCR5 tropic, replicated preferentially in activated primary T-Iymphocytes but not monocyte-derived macrophages, and were effectively shielded from most heterologous or broadly neutralizing antibodies. By 3 months of infection, the evolving viral quasispecies in three subjects showed mutational fixation at only 2-5 discreet genomic loci. By 6-12 months, mutational fixation was evident at 18-27 genomic loci. Some, but not all, of these mutations were attributable to virus escape from cytotoxic Tlymphocytes or neutralizing antibodies, suggesting that other viral or host factors may influence early HIV -1 fitness.

  2. Linkage disequilibrium analysis in young populations: Pseudo-vitamin D-deficiency rickets and the founder effect in French Canadians

    Energy Technology Data Exchange (ETDEWEB)

    Labuda, M.; Glorieux, F.H. [McGill Univ., Montreal (Canada); Labuda, D.; Korab-Laskowska, M. [Universite de Montreal (Canada)] [and others

    1996-09-01

    Pseudo-vitamin D-deficiency rickets (PDDR) was mapped close to D12S90 and between proximal D12S312 and distal (D12S305, D12S104) microsatellites that were subsequently found on a single YAC clone. Analysis of a complex haplotype in linkage disequilibrium (LD) with the disease discriminated among distinct founder effects in French Canadian populations in Acadia and in Charlevoix-Saguenay-Lac-Saint-Jean (Ch-SLSJ), as well as an earlier one in precolonial Europe. A simple demographic model suggested the historical age of the founder effect in Ch-SLSJ to be {approximately}12 generations. The corresponding LD data are consistent with this figure when they are analyzed within the framework of Luria-Delbruck model, which takes into account the population growth. Population sampling due to a limited number of first settlers and the rapid demographic expansion appear to have played a major role in the founding of PDDR in Ch-SLSJ and, presumably, other genetic disorders endemic to French Canada. Similarly, the founder effect in Ashkenazim, coinciding with their early settlement in medieval Poland and subsequent expansion eastward, could explain the origin of frequent genetic diseases in this population. 48 refs., 5 figs., 2 tabs.

  3. Cost effectiveness of population based BRCA1 founder mutation testing in Sephardi Jewish women.

    Science.gov (United States)

    Patel, Shreeya; Legood, Rosa; Evans, D Gareth; Turnbull, Clare; Antoniou, Antonis C; Menon, Usha; Jacobs, Ian; Manchanda, Ranjit

    2018-04-01

    Population-based BRCA1/BRCA2 founder-mutation testing has been demonstrated as cost effective compared with family history based testing in Ashkenazi Jewish women. However, only 1 of the 3 Ashkenazi Jewish BRCA1/BRCA2 founder mutations (185delAG[c.68_69delAG]), 5382insC[c.5266dupC]), and 6174delT[c.5946delT]) is found in the Sephardi Jewish population (185delAG[c.68_69delAG]), and the overall prevalence of BRCA mutations in the Sephardi Jewish population is accordingly lower (0.7% compared with 2.5% in the Ashkenazi Jewish population). Cost-effectiveness analyses of BRCA testing have not previously been performed at these lower BRCA prevalence levels seen in the Sephardi Jewish population. Here we present a cost-effectiveness analysis for UK and US populations comparing population testing with clinical criteria/family history-based testing in Sephardi Jewish women. A Markov model was built comparing the lifetime costs and effects of population-based BRCA1 testing, with testing using family history-based clinical criteria in Sephardi Jewish women aged ≥30 years. BRCA1 carriers identified were offered magnetic resonance imaging/mammograms and risk-reducing surgery. Costs are reported at 2015 prices. Outcomes include breast cancer, ovarian cancer, and excess deaths from heart disease. All costs and outcomes are discounted at 3.5%. The time horizon is lifetime, and perspective is payer. The incremental cost-effectiveness ratio per quality-adjusted life-year was calculated. Parameter uncertainty was evaluated through 1-way and probabilistic sensitivity analysis. Population testing resulted in gain in life expectancy of 12 months (quality-adjusted life-year = 1.00). The baseline discounted incremental cost-effectiveness ratio for UK population-based testing was £67.04/quality-adjusted life-year and for US population was $308.42/quality-adjusted life-year. Results were robust in the 1-way sensitivity analysis. The probabilistic sensitivity analysis showed 100% of

  4. Master John of Arderne (1307-1380): a founder of modern surgery.

    Science.gov (United States)

    Pearn, John

    2012-01-01

    John of Arderne (1307-1380) was one founder of surgery as the profession is known today. He was the first English surgeon of whom biographic details survive. Born on the Arderne Estates at Newark, England, he served as a military surgeon in France in campaigns where gunpowder was used in combat for the first time. His best-known work, the Practica (De Arte Phisicali et de Cirurgia), formed the basis of practical surgical teaching in the medical schools of medieval Europe. Biographic research of primary and secondary archives and documents. John of Arderne's surgical practice was undertaken against a background of turbulent political, military and medical events. He survived the Black Death (1347) and its cyclical recurrences. He lived through the turbulent reigns of Edward II and Edward III and practised in London in the decades preceding the simmering unrest which preceded the Peasant's Revolt of 1381. Surgical and medical practice in the late Middle Ages was enmeshed in astrological beliefs. It was greatly influenced by church doctrine of disease causation. In this paper, the known details of John of Arderne's life are placed in the perspective of these societal and professional influences. He is one of several pre-Renaissance European doctors who were the first to challenge the received medical lore of Galen and later Arabic surgeons. Writing when he was 70 years of age, John of Arderne was the first to advocate that surgeons should trust their own clinical experience 'Wele ymagynyng subtile things' rather than following the directions of others, even including those advocated by himself. © 2011 The Author. ANZ Journal of Surgery © 2011 Royal Australasian College of Surgeons.

  5. Counting the founders: the matrilineal genetic ancestry of the Jewish Diaspora.

    Science.gov (United States)

    Behar, Doron M; Metspalu, Ene; Kivisild, Toomas; Rosset, Saharon; Tzur, Shay; Hadid, Yarin; Yudkovsky, Guennady; Rosengarten, Dror; Pereira, Luisa; Amorim, Antonio; Kutuev, Ildus; Gurwitz, David; Bonne-Tamir, Batsheva; Villems, Richard; Skorecki, Karl

    2008-04-30

    The history of the Jewish Diaspora dates back to the Assyrian and Babylonian conquests in the Levant, followed by complex demographic and migratory trajectories over the ensuing millennia which pose a serious challenge to unraveling population genetic patterns. Here we ask whether phylogenetic analysis, based on highly resolved mitochondrial DNA (mtDNA) phylogenies can discern among maternal ancestries of the Diaspora. Accordingly, 1,142 samples from 14 different non-Ashkenazi Jewish communities were analyzed. A list of complete mtDNA sequences was established for all variants present at high frequency in the communities studied, along with high-resolution genotyping of all samples. Unlike the previously reported pattern observed among Ashkenazi Jews, the numerically major portion of the non-Ashkenazi Jews, currently estimated at 5 million people and comprised of the Moroccan, Iraqi, Iranian and Iberian Exile Jewish communities showed no evidence for a narrow founder effect, which did however characterize the smaller and more remote Belmonte, Indian and the two Caucasus communities. The Indian and Ethiopian Jewish sample sets suggested local female introgression, while mtDNAs in all other communities studied belong to a well-characterized West Eurasian pool of maternal lineages. Absence of sub-Saharan African mtDNA lineages among the North African Jewish communities suggests negligible or low level of admixture with females of the host populations among whom the African haplogroup (Hg) L0-L3 sub-clades variants are common. In contrast, the North African and Iberian Exile Jewish communities show influence of putative Iberian admixture as documented by mtDNA Hg HV0 variants. These findings highlight striking differences in the demographic history of the widespread Jewish Diaspora.

  6. Founder effects and the evolution of asymmetrical sexual isolation in a rapidly-speciating clade

    Directory of Open Access Journals (Sweden)

    Kevin P. OH, Gina L. CONTE, Kerry L. SHAW

    2013-04-01

    Full Text Available Sexual isolation resulting from differences in mate choice behaviors is a hallmark of rapidly-speciating lineages. When present, asymmetrical sexual isolation may provide insights into the mechanisms responsible for the evolutionary change in mate signaling traits. In particular, Kaneshiro’s hypothesis suggests that divergence in sexual characters between populations may arise in allopatry when ‘derived’ founding populations are subject to severe population bottlenecks, accompanied by a relaxation of sexual selection relative to ‘ancestral’ source populations. In the present study, we tested predictions of asymmetrical sexual isolation between two allopatric species of Hawaiian Laupala crickets, representing ‘ancestral’ (L. makaio and ‘derived’ (L. nigra taxa. While crickets in this genus are notable for rapid divergence of male courtship songs, these species share similar song types, thus suggesting that patterns of sexual isolation are likely due to other mating cues. Analysis of behavioral responses in conspecific and heterospecific ‘no-choice’ mating trials revealed pronounced asymmetrical isolation in the direction predicted by Kaneshiro’s hypothesis, wherein we observed a significant reduction in mating success for crosses involving ‘derived’ males paired with ‘ancestral’ females, compared to the reciprocal heterospecific and both conspecific pairings. Further dissection of courtship behaviors suggested this difference did not reflect male mate choice, but rather, marked reduced spermatophore acceptance rates by ‘ancestral’ females paired with ‘derived’ males. The results are discussed with respect to founder effect models of speciation and the potential role of chemosensory signals in mate choice in these species [Current Zoology 59 (2: 230-238, 2013].

  7. Um modelo semântico de publicações eletrônicas | A semantic model for electronic publishing

    Directory of Open Access Journals (Sweden)

    Carlos Henrique Marcondes

    2011-03-01

    Full Text Available Resumo Publicações eletrônicas, apesar dos avanços das Tecnologias da Informação, são ainda calcados no modelo impresso. O formato textual impede que programas possam ser usados para o processamento “semântico” desses conteúdos. È porposto um modelo “semântico” de publicações cientificas eletrônicas, no qual as conclusões contidas no texto do artigo fornecidas por autores e representadas em formato “inteligível” por programas, permitindo recuperação semântica, identificação de indícios de novas descobertas científicas e de incoerências sobre este conhecimento. O modelo se baseia nos conceitos de estrutura profunda, ou semântica, da linguagem (CHOMSKY, 1975, de microestrutura, macroestrutura e superestrutura, (KINTSH, VAN DIJK, 1972, na estrutura retórica de artigos científicos (HUTCHINS, 1977, (GROSS, 1990 e nos elementos de metodologia cientifica, como problema, questão, objetivo, hipótese, experimento e conclusão. Resulta da análise de 89 artigos biomédicos. Foi desenvolvido um protótipo de sistema que implementa parcialmente o modelo. Questionários foram usados com autores para embasar o desenvolvimento do protótipo. O protótipo foi testando com pesquisadores-autores. Foram identificados quatro padrões de raciocínio e encadeamento dos elementos semânticos em artigos científicos. O modelo de conteúdo foi implementado como uma ontologia computacional. Foi desenvolvido e avaliado um protótipo de uma interface web de submissão artigos pelos autores a um sistema eletrônico de publicação de periódicos que implementa o modelo. Palavras-chave publicações eletrônicas; metodológica científica; comunicação científica; representação do conhecimento; ontologias; processamento semântico de conteúdos; e-Ciência Abstract Electronic publishing, although Information Technologies advancements, are still based in the print text model. The textual format prevents programs to semantic process

  8. Ética na publicação de pesquisas sobre leishmaniose visceral humana em periódicos nacionais

    OpenAIRE

    Malafaia, Guilherme; Rodrigues, Aline Sueli de Lima; Talvani, André

    2010-01-01

    OBJETIVO: Analisar os aspectos éticos dos artigos nacionais sobre leishmaniose visceral humana publicados após a Resolução CNS 196/1996 e analisar a política de periódicos brasileiros sobre ética em pesquisa. MÉTODOS: Estudo exploratório de natureza bibliográfica e documental. A seleção das publicações sobre pesquisas envolvendo seres humanos foi realizada na base SciELO Brasil a partir de 1996. Foram analisadas lacunas relacionadas às políticas editoriais dos periódicos médicos a partir de i...

  9. Nature of the basement of the East Anatolian plateau: Implications for the lithospheric foundering processes

    Science.gov (United States)

    Topuz, G.; Candan, O.; Zack, T.; Yılmaz, A.

    2017-12-01

    Anatolian plateau have resulted from other processes of lithospheric foundering, rather than just slab steepening and break-off. This research is funded by a research grant (#114Y228) from TÜBİTAK.

  10. [Professor Adam Nowosławski (1925-2012)--founder of the Polish School of Immunopathology].

    Science.gov (United States)

    Madaliński, Kazimierz

    2012-01-01

    Professor dr med. Adam Nowosławski, has died at age of 87, on February 3, 2012, the founder of the Polish school of immunopathology, member of Polish Academy of Sciences and of Polish Academy of Art and Sciences. Professor was born on April 30, 1925 in Rzeszów (SE Poland). During the Second World War he took part in the anti-nazi resistance movement; he was the soldier of the 'Baszta' regiment of the Home Army. Subsequently, he was imprisoned in the Pawiak and concentration camps: Majdanek and Buchenwald. The medical studies he has completed at Warsaw Medical Academy between 1946-1951. The degree of doctor of medicine Prof. Adam Nowosławski has obtained in 1963, habilitation degree in the field of immunopathology--in 1966; the title of Professor he has obtained in 1980. His scientific achievements consist of 170 publications, including 101 original papers. His publications were quoted in several American books for students and physicians. Topics of his early papers concerned the immunopatogenesis ofPneumocystis carinii--induced pneumonia in premature babies, immunopatogenesis of rheumatoid arthritis, and the origin of rheumatoid factor. The enormous role in the field of hepatology played research on the virus of hepatitis B. These studies dealt with the discovery of HB core antigen which had the cellular localization different from HB surface antigen and with the parameters of the immune response to infection. Papers published on this topic were the mostly quoted in the literature and earned him national awards. The activity of Prof. Adam Nowosławski in the field of HIV/AIDS prevention was honored by the special prize of the Minister of Health. Professor was the honorary member of the two Societies: Polish Society of Pathologists and Polish Society of Hepatology. He was also the member of International Association for the Study of the Liver and International Academy of Pathology. Prof. Adam Nowosławski received the national medals: Polonia Restituta Crosses

  11. Identification of novel BRCA founder mutations in Middle Eastern breast cancer patients using capture and Sanger sequencing analysis.

    Science.gov (United States)

    Bu, Rong; Siraj, Abdul K; Al-Obaisi, Khadija A S; Beg, Shaham; Al Hazmi, Mohsen; Ajarim, Dahish; Tulbah, Asma; Al-Dayel, Fouad; Al-Kuraya, Khawla S

    2016-09-01

    Ethnic differences of breast cancer genomics have prompted us to investigate the spectra of BRCA1 and BRCA2 mutations in different populations. The prevalence and effect of BRCA 1 and BRCA 2 mutations in Middle Eastern population is not fully explored. To characterize the prevalence of BRCA mutations in Middle Eastern breast cancer patients, BRCA mutation screening was performed in 818 unselected breast cancer patients using Capture and/or Sanger sequencing. 19 short tandem repeat (STR) markers were used for founder mutation analysis. In our study, nine different types of deleterious mutation were identified in 28 (3.4%) cases, 25 (89.3%) cases in BRCA 1 and 3 (10.7%) cases in BRCA 2. Seven recurrent mutations identified accounted for 92.9% (26/28) of all the mutant cases. Haplotype analysis was performed to confirm c.1140 dupG and c.4136_4137delCT mutations as novel putative founder mutation, accounting for 46.4% (13/28) of all BRCA mutant cases and 1.6% (13/818) of all the breast cancer cases, respectively. Moreover, BRCA 1 mutation was significantly associated with BRCA 1 protein expression loss (p = 0.0005). Our finding revealed that a substantial number of BRCA mutations were identified in clinically high risk breast cancer from Middle East region. Identification of the mutation spectrum, prevalence and founder effect in Middle Eastern population facilitates genetic counseling, risk assessment and development of cost-effective screening strategy. © 2016 UICC.

  12. "Founder crops" v. wild plants: Assessing the plant-based diet of the last hunter-gatherers in southwest Asia

    Science.gov (United States)

    Arranz-Otaegui, Amaia; González Carretero, Lara; Roe, Joe; Richter, Tobias

    2018-04-01

    The Natufian culture (c. 14.6-11.5 ka cal. BP) represents the last hunter-gatherer society that inhabited southwest Asia before the development of plant food production. It has long been suggested that Natufians based their economy on the exploitation of the wild ancestors of the Neolithic "founder crops", and that these hunter-gatherers were therefore on the "threshold to agriculture". In this work we review the available data on Natufian plant exploitation and we report new archaeobotanical evidence from Shubayqa 1, a Natufian site located in northeastern Jordan (14.6-11.5 ka cal. BP). Shubayqa 1 has produced an exceptionally large plant assemblage, including direct evidence for the continuous exploitation of club-rush tubers (often regarded as "missing foods") and other wild plants, which were probably used as food, fuel and building materials. Taking together this data we evaluate the composition of archaeobotanical assemblages (plant macroremains) from the Natufian to the Early Pre-Pottery Neolithic B (EPPNB). Natufian assemblages comprise large proportions of non-founder plant species (>90% on average), amongst which sedges, small-seeded grasses and legumes, and fruits and nuts predominate. During the Pre-Pottery Neolithic, in particular the EPPNB, the presence of "founder crops" increases dramatically and constitute up to c. 42% of the archaeobotanical assemblages on average. Our results suggest that plant exploitation strategies during the Natufian were very different from those attested during subsequent Neolithic periods. We argue that historically driven interpretations of the archaeological record have over-emphasized the role of the wild ancestors of domesticated crops previous to the emergence of agriculture.

  13. The Expression of TALEN before Fertilization Provides a Rapid Knock-Out Phenotype in Xenopus laevis Founder Embryos.

    Science.gov (United States)

    Miyamoto, Kei; Suzuki, Ken-Ichi T; Suzuki, Miyuki; Sakane, Yuto; Sakuma, Tetsushi; Herberg, Sarah; Simeone, Angela; Simpson, David; Jullien, Jerome; Yamamoto, Takashi; Gurdon, J B

    2015-01-01

    Recent advances in genome editing using programmable nucleases have revolutionized gene targeting in various organisms. Successful gene knock-out has been shown in Xenopus, a widely used model organism, although a system enabling less mosaic knock-out in founder embryos (F0) needs to be explored in order to judge phenotypes in the F0 generation. Here, we injected modified highly active transcription activator-like effector nuclease (TALEN) mRNA to oocytes at the germinal vesicle (GV) stage, followed by in vitro maturation and intracytoplasmic sperm injection, to achieve a full knock-out in F0 embryos. Unlike conventional injection methods to fertilized embryos, the injection of TALEN mRNA into GV oocytes allows expression of nucleases before fertilization, enabling them to work from an earlier stage. Using this procedure, most of developed embryos showed full knock-out phenotypes of the pigmentation gene tyrosinase and/or embryonic lethal gene pax6 in the founder generation. In addition, our method permitted a large 1 kb deletion. Thus, we describe nearly complete gene knock-out phenotypes in Xenopus laevis F0 embryos. The presented method will help to accelerate the production of knock-out frogs since we can bypass an extra generation of about 1 year in Xenopus laevis. Meantime, our method provides a unique opportunity to rapidly test the developmental effects of disrupting those genes that do not permit growth to an adult able to reproduce. In addition, the protocol shown here is considerably less invasive than the previously used host transfer since our protocol does not require surgery. The experimental scheme presented is potentially applicable to other organisms such as mammals and fish to resolve common issues of mosaicism in founders.

  14. International distribution and age estimation of the Portuguese BRCA2 c.156_157insAlu founder mutation

    DEFF Research Database (Denmark)

    Peixoto, Ana; Santos, Catarina; Pinheiro, Manuela

    2011-01-01

    The c.156_157insAlu BRCA2 mutation has so far only been reported in hereditary breast/ovarian cancer (HBOC) families of Portuguese origin. Since this mutation is not detectable using the commonly used screening methodologies and must be specifically sought, we screened for this rearrangement...... individuals requesting predictive testing living in France and in the USA, all being Portuguese immigrants. After performing an extensive haplotype study in carrier families, we estimate that this founder mutation occurred 558 ± 215 years ago. We further demonstrate significant quantitative differences...... HBOC families from Portugal or with Portuguese ancestry are specifically tested for this rearrangement....

  15. International distribution and age estimation of the Portuguese BRCA2 c.156_157insAlu founder mutation

    DEFF Research Database (Denmark)

    Peixoto, Ana; Santos, Catarina; Pinheiro, Manuela

    2011-01-01

    The c.156_157insAlu BRCA2 mutation has so far only been reported in hereditary breast/ovarian cancer (HBOC) families of Portuguese origin. Since this mutation is not detectable using the commonly used screening methodologies and must be specifically sought, we screened for this rearrangement...... individuals requesting predictive testing living in France and in the USA, all being Portuguese immigrants. After performing an extensive haplotype study in carrier families, we estimate that this founder mutation occurred 558 +/- 215 years ago. We further demonstrate significant quantitative differences...... HBOC families from Portugal or with Portuguese ancestry are specifically tested for this rearrangement....

  16. Novel Founder Mutation in FANCA Gene (c.3446_3449dupCCCT) Among Romani Patients from the Balkan Region

    OpenAIRE

    Marija Dimishkovska; Vjosa Mulliqi Kotori; Zoran Gucev; Svetlana Kocheva; Momir Polenakovic; Dijana Plaseska-Karanfilska

    2018-01-01

    Background: Fanconi anemia is a rare autosomal recessive or X-linked disorder characterised by clinical and genetic heterogeneity. Most fanconi anemia patients harbour homozygous or double heterozygous mutations in the FANCA (60-65%), FANCC (10-15%), FANCG (~10%) or FANCD2 (3-6%) genes. We have already reported the FANCA variant c.190–256_283+1680del2040dupC as a founder mutation among Macedonian fanconi anemia patients of Gypsy-like ethnic origin. Here, we present a novel FANCA mutation in t...

  17. Molecular and genealogical evidence for a founder effect in Fanconi anemia families of the Afrikaner population of South Africa

    Science.gov (United States)

    Tipping, A. J.; Pearson, T.; Morgan, N. V.; Gibson, R. A.; Kuyt, L. P.; Havenga, C.; Gluckman, E.; Joenje, H.; de Ravel, T.; Jansen, S.; Mathew, C. G.

    2001-01-01

    Fanconi anemia (FA) is a rare, genetically heterogeneous autosomal recessive disorder associated with progressive aplastic anemia, congenital abnormalities, and cancer. FA has a very high incidence in the Afrikaner population of South Africa, possibly due to a founder effect. Previously we observed allelic association between polymorphic markers flanking the FA group A gene (FANCA) and disease chromosomes in Afrikaners. We genotyped 26 FA families with microsatellite and single nucleotide polymorphic markers and detected five FANCA haplotypes. Mutation scanning of the FANCA gene revealed association of these haplotypes with four different mutations. The most common was an intragenic deletion of exons 12–31, accounting for 60% of FA chromosomes in 46 unrelated Afrikaner FA patients, while two other mutations accounted for an additional 20%. Screening for these mutations in the European populations ancestral to the Afrikaners detected one patient from the Western Ruhr region of Germany who was heterozygous for the major deletion. The mutation was associated with the same unique FANCA haplotype as in Afrikaner patients. Genealogical investigation of 12 Afrikaner families with FA revealed that all were descended from a French Huguenot couple who arrived at the Cape on June 5, 1688, whereas mutation analysis showed that the carriers of the major mutation were descendants of this same couple. The molecular and genealogical evidence is consistent with transmission of the major mutation to Western Germany and the Cape near the end of the 17th century, confirming the existence of a founder effect for FA in South Africa. PMID:11344308

  18. A Founder Large Deletion Mutation in Xeroderma Pigmentosum-Variant Form in Tunisia: Implication for Molecular Diagnosis and Therapy

    Directory of Open Access Journals (Sweden)

    Mariem Ben Rekaya

    2014-01-01

    Full Text Available Xeroderma pigmentosum Variant (XP-V form is characterized by a late onset of skin symptoms. Our aim is the clinical and genetic investigations of XP-V Tunisian patients in order to develop a simple tool for early diagnosis. We investigated 16 suspected XP patients belonging to ten consanguineous families. Analysis of the POLH gene was performed by linkage analysis, long range PCR, and sequencing. Genetic analysis showed linkage to the POLH gene with a founder haplotype in all affected patients. Long range PCR of exon 9 to exon 11 showed a 3926 bp deletion compared to control individuals. Sequence analysis demonstrates that this deletion has occurred between two Alu-Sq2 repetitive sequences in the same orientation, respectively, in introns 9 and 10. We suggest that this mutation POLH NG_009252.1: g.36847_40771del3925 is caused by an equal crossover event that occurred between two homologous chromosomes at meiosis. These results allowed us to develop a simple test based on a simple PCR in order to screen suspected XP-V patients. In Tunisia, the prevalence of XP-V group seems to be underestimated and clinical diagnosis is usually later. Cascade screening of this founder mutation by PCR in regions with high frequency of XP provides a rapid and cost-effective tool for early diagnosis of XP-V in Tunisia and North Africa.

  19. Novel Founder Mutation in FANCA Gene (c.3446_3449dupCCCT) Among Romani Patients from the Balkan Region.

    Science.gov (United States)

    Dimishkovska, Marija; Kotori, Vjosa Mulliqi; Gucev, Zoran; Kocheva, Svetlana; Polenakovic, Momir; Plaseska-Karanfilska, Dijana

    2018-01-20

    Fanconi anemia is a rare autosomal recessive or X-linked disorder characterised by clinical and genetic heterogeneity. Most fanconi anemia patients harbour homozygous or double heterozygous mutations in the FANCA (60-65%), FANCC (10-15%), FANCG (~10%) or FANCD2 (3-6%) genes. We have already reported the FANCA variant c.190-256_283+1680del2040dupC as a founder mutation among Macedonian fanconi anemia patients of Gypsy-like ethnic origin. Here, we present a novel FANCA mutation in two patients from Macedonia and Kosovo. The novel FANCA mutation c.3446_3449dupCCCT was identified in two fanconi anemia patients with Romany ethnicity; a 2-year-old girl from Macedonia who is a compound heterozygote for a previously reported FANCA c.190-256_283+1680del2040dupC and the novel mutation and a 10-year-old girl from Kosovo who is a homozygote for the novel FANCA c.3446_3449dupCCCT mutation. The novel mutation is located in exon 35 in the FAAP20-binding domain which plays a crucial role in the FANCA -FAAP20 interaction and is required for integrity of the fanconi anemia pathway. The finding of the FANCA c.3446_3449dupCCCT mutation in two unrelated FA patients with Romani ethnicity from Macedonia and Kosovo suggests it is a founder mutation in the Romani population living in the Balkan region.

  20. A founder large deletion mutation in Xeroderma pigmentosum-Variant form in Tunisia: implication for molecular diagnosis and therapy.

    Science.gov (United States)

    Ben Rekaya, Mariem; Laroussi, Nadia; Messaoud, Olfa; Jones, Mariem; Jerbi, Manel; Naouali, Chokri; Bouyacoub, Yosra; Chargui, Mariem; Kefi, Rym; Fazaa, Becima; Boubaker, Mohamed Samir; Boussen, Hamouda; Mokni, Mourad; Abdelhak, Sonia; Zghal, Mohamed; Khaled, Aida; Yacoub-Youssef, Houda

    2014-01-01

    Xeroderma pigmentosum Variant (XP-V) form is characterized by a late onset of skin symptoms. Our aim is the clinical and genetic investigations of XP-V Tunisian patients in order to develop a simple tool for early diagnosis. We investigated 16 suspected XP patients belonging to ten consanguineous families. Analysis of the POLH gene was performed by linkage analysis, long range PCR, and sequencing. Genetic analysis showed linkage to the POLH gene with a founder haplotype in all affected patients. Long range PCR of exon 9 to exon 11 showed a 3926 bp deletion compared to control individuals. Sequence analysis demonstrates that this deletion has occurred between two Alu-Sq2 repetitive sequences in the same orientation, respectively, in introns 9 and 10. We suggest that this mutation POLH NG_009252.1: g.36847_40771del3925 is caused by an equal crossover event that occurred between two homologous chromosomes at meiosis. These results allowed us to develop a simple test based on a simple PCR in order to screen suspected XP-V patients. In Tunisia, the prevalence of XP-V group seems to be underestimated and clinical diagnosis is usually later. Cascade screening of this founder mutation by PCR in regions with high frequency of XP provides a rapid and cost-effective tool for early diagnosis of XP-V in Tunisia and North Africa.

  1. Características bibliométricas e sociométricas de publicações da área ambiental em congressos e períodicos nacionais

    Directory of Open Access Journals (Sweden)

    Ilse Maria Beuren

    2014-03-01

    Full Text Available http://dx.doi.org/10.5007/1983-4535.2014v7n1p234 O estudo objetiva examinar características bibliométricas e sociométricas de publicações da área ambiental no Congresso USP de Controladoria e Contabilidade, EnANPAD e em periódicos de Administração e Contabilidade no período de 2000 a 2010. Pesquisa descritiva com abordagem quantitativa foi realizada por meio de pesquisa documental. Os resultados da pesquisa bibliométrica destacam que: i o volume de publicações sobre o tema no EnANPAD aumentou significativamente no decorrer do período analisado; ii os periódicos O&S, RAE, RAUSP e REAd apresentam tendência ascendente no volume de publicações sobre o tema; iii quanto aos procedimentos metodológicos, o Congresso USP e o EnANPAD priorizaram estudos de caso e survey e os periódicos estudos teóricos, mas em todos prevaleceu a abordagem qualitativa; iv dentre as categorias da temática ambiental prevaleceu a Gestão Ambiental e evolução nas publicações sobre Evidenciação Ambiental. Os resultados da pesquisa sociométrica revelam que a configuração estrutural dos relacionamentos dos autores prepondera nos congressos e há alguns autores que possuem laços de publicações com autores de outros periódicos. Conclui-se que as características bibliométricas e sociométricas das publicações da área ambiental sinalizam que o tema continua em evidência e que a configuração estrutural dos relacionamentos dos autores apresenta lacunas principalmente nos periódicos pesquisados.

  2. A qualidade das publicações científicas: considerações de um Editor de Área ao final do mandato Quality of scientific puplications: considerations of an editor at the end of the mandate

    Directory of Open Access Journals (Sweden)

    Ulysses Paulino de Albuquerque

    2009-03-01

    Full Text Available A qualidade das publicações científicas vem sendo discutida na atualidade considerando diferentes perspectivas. Neste texto, examina-se alguns dos principais problemas relativos à produção textual em ciência, com ênfase para os considerados de má conduta. Adicionalmente, são apresentadas sugestões para autores, revisores e editores no sentido de evitar condutas inadequadas no processo de publicação de trabalhos científicos.Quality of scientific publications is being currently discussed considering different perspectives. In this text, we examine some of the main problems concerning textual production in science, emphasizing those considered of bad behaviors. Additionally, we present suggestions for authors, reviewers and editors in order to avoid misconducts in the publication process of scientific papers.

  3. A Pesquisa Design Science no Brasil segundo as Publicações em Administração da Informação

    Directory of Open Access Journals (Sweden)

    José Osvaldo De Sordi

    2015-09-01

    Full Text Available Este artigo realiza uma revisão da literatura das pesquisas publicadas pela academia brasileira de administração da informação com o objetivo de analisar o quanto se aplica e como se pratica os princípios da pesquisa design science (DS. A amostra da pesquisa foi extraída de 257 artigos publicados por esta área, nos anais do EnANPAD, no período 2008-2012. Observou-se o interesse manifesto dos pesquisadores pela DS, considerando que há publicações referentes ao desenvolvimento de novos artefatos. Estas pesquisas, porém, não observaram aspectos centrais da DS, como: associação do artefato a problemas do ambiente de negócios e evidenciação da utilidade do artefato por meio de testes com variáveis associadas ao problema.

  4. Design moveleiro: um estudo sobre abordagens de publicações internacionais por meio de revisão sistemática

    Directory of Open Access Journals (Sweden)

    Gabriel Bergmann Borges Vieira

    2016-08-01

    Full Text Available A competitividade no setor moveleiro e a busca por diferenciação amplia a importância do design como subsídio para aumentar a performance empresarial. As diferentes abordagens de design moveleiro, aproximando-se às variadas áreas do conhecimento como gestão, comunicação e engenharia impulsiona para a busca por compreender de quais as características predominantes em estudos publicados nos periódicos acadêmicos em nível internacional. Este trabalho tem como objetivo de pesquisa analisar as principais abordagens dos estudos sobre Design Moveleiro. A metodologia de pesquisa utilizada foi a revisão sistemática da literatura uma vez que viabiliza conhecimento acerca do tema de forma estruturada, clara e objetiva. Como resultado, o trabalho apresenta as principais publicações nos últimos cinco anos, as características desses estudos e os focos de conteúdos abordados, permitindo a compreensão do estado da arte de pesquisas sobre o Design Moveleiro, especialmente relacionados com a busca por performance empresarial.

  5. O lúdico e o ensino de Geociências no Brasil: principais tendências das publicações na área de Ciências da Natureza

    Directory of Open Access Journals (Sweden)

    Danilo Missias Teixeira

    2018-01-01

    Full Text Available As atividades lúdicas são metodologias de ensino que vêm conquistando espaço no Ensino de Ciências; proporcionam um estudo dos conceitos de forma mais dinâmica e prazerosa. Todavia, quando se trata dos conceitos de Geociências as dificuldades apresentadas pelos professores de Ciências Exatas e Biológicas acabam por fazer com que estes profissionais não elaborem propostas vinculadas a tais conceitos. O objetivo deste trabalho é, portanto, identificar na literatura científica do Ensino de Ciências as principais tendências de pesquisas com características lúdicas que possuam como foco os conceitos de Geociências. Para isso, foi realizada uma busca em: (a banco de Teses e Dissertações da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES, e (b periódicos vinculados ao Ensino de Ciências. Como resultado, foi possível observar que as publicações lúdicas no Ensino de Ciências apresentam as seguintes tendências: (1 A maior parte das publicações tem origem na região Sudeste, principalmente nos estados de Rio de Janeiro e São Paulo; (2 O número de publicações é crescente a partir do ano de 2014, com ponto forte no ano 2016; (3 a maior área de conhecimento a apresentar trabalhos é Química, seguida de Biologia; (4 as publicações são, em sua maior parte, experiências realizadas no Ensino Médio, e (5 a modalidade lúdica preferencial é “Jogo Didático”.

  6. A common founder mutation in FANCA underlies the world's highest prevalence of Fanconi anemia in Gypsy families from Spain.

    Science.gov (United States)

    Callén, Elsa; Casado, José A; Tischkowitz, Marc D; Bueren, Juan A; Creus, Amadeu; Marcos, Ricard; Dasí, Angeles; Estella, Jesús M; Muñoz, Arturo; Ortega, Juan J; de Winter, Johan; Joenje, Hans; Schindler, Detlev; Hanenberg, Helmut; Hodgson, Shirley V; Mathew, Christopher G; Surrallés, Jordi

    2005-03-01

    Fanconi anemia (FA) is a genetic disease characterized by bone marrow failure and cancer predisposition. Here we have identified Spanish Gypsies as the ethnic group with the world's highest prevalence of FA (carrier frequency of 1/64-1/70). DNA sequencing of the FANCA gene in 8 unrelated Spanish Gypsy FA families after retroviral subtyping revealed a homozygous FANCA mutation (295C>T) leading to FANCA truncation and FA pathway disruption. This mutation appeared specific for Spanish Gypsies as it is not found in other Gypsy patients with FA from Hungary, Germany, Slovakia, and Ireland. Haplotype analysis showed that Spanish Gypsy patients all share the same haplotype. Our data thus suggest that the high incidence of FA among Spanish Gypsies is due to an ancestral founder mutation in FANCA that originated in Spain less than 600 years ago. The high carrier frequency makes the Spanish Gypsies a population model to study FA heterozygote mutations in cancer.

  7. [Max Isserlin, Kantian orientation at Königsberg, psychotherapist with Kraepelin, founder of child psychiatry at Munich, emigrant to Britain].

    Science.gov (United States)

    Peters, U H

    2002-01-01

    This account of the life and work of Max Isserlin (1879 - 1941) wants to be a reminder of a German-Jewish fate next to Kraepelin and as a forced emigrant. Immediately after his studies at Königsberg Isserlin in 1903 came to Kraepelin at Heidelberg, later he followed him to Munich. All his life he kept a Kantian orientation and defended Kraepelin's positions out of this background. Kraepelin entrusted to him all of psychotherapy, theory and practice, which Isserlin for at least 18 years gave courses of in Kraepelin's department. His textbook of psychotherapy thus transmissions Kraepelins convictions about this topic also. During World War I Isserlin was the head of a field-hospital for brain damaged soldiers and continued working this way after the end of the war. Finally he became the founder of child psychiatry in Munich, until he was forced to leave Germany for Britain with a heavy heart.

  8. Jean-Alfred Fournier - the founder of the European venereology and dermatology (on the one hundredth death anniversary

    Directory of Open Access Journals (Sweden)

    O. A. Kisteneva

    2014-01-01

    Full Text Available The article presents a life story of a great French dermatologist and venereologist, one of the founders of the theory of syphilis Jean-Alfred Fournier (1832-1914. It provides data on the published works by Jean-Alfred Fournier, some of which earned him a doctoral degree. It also provides data on Fournier’s election as a member of the French Academy of Medicine in 1879 as well as on the founding of the French Society of Dermatology and Syphiligraphy by Fournier and other French dermatologists in 1889. The article defines the contribution made by Fournier to the development of venereology and practical medicine in the second half of the 19th century and early 20th century.

  9. Fragile X founder effect and distribution of CGG repeats among the mentally retarded population of Andalusia, South Spain

    Directory of Open Access Journals (Sweden)

    Yolanda de Diego

    2002-01-01

    Full Text Available Fragile X syndrome is the most common inherited form of mental retardation. We investigated the prevalence of the Fragile X syndrome in the population with mental retardation of unknown etiology in Andalusia, South Spain. We analyzed 322 unrelated patients (280 males and 42 females, and found a fragile X syndrome frequency of 6.5%. Among the non-fragile X chromosomes, the 29 CGG repeat was the most common allele. At the linked microsatellite DXS548 locus, we found a new allele which we called "allele 10" (17 CA. Similar to other south European populations, allele 2 (25 CA at the DXS548 locus and the fragile X allele were in linkage disequilibrium supporting the idea of a common founder chromosome predisposing to the CGG expansion.

  10. Novel Founder Mutation in FANCA Gene (c.3446_3449dupCCCT Among Romani Patients from the Balkan Region

    Directory of Open Access Journals (Sweden)

    Marija Dimishkovska

    2018-02-01

    Full Text Available Background: Fanconi anemia is a rare autosomal recessive or X-linked disorder characterised by clinical and genetic heterogeneity. Most fanconi anemia patients harbour homozygous or double heterozygous mutations in the FANCA (60-65%, FANCC (10-15%, FANCG (~10% or FANCD2 (3-6% genes. We have already reported the FANCA variant c.190–256_283+1680del2040dupC as a founder mutation among Macedonian fanconi anemia patients of Gypsy-like ethnic origin. Here, we present a novel FANCA mutation in two patients from Macedonia and Kosovo. Case Report: The novel FANCA mutation c.3446_3449dupCCCT was identified in two fanconi anemia patients with Romany ethnicity; a 2-year-old girl from Macedonia who is a compound heterozygote for a previously reported FANCA c.190-256_283+1680del2040dupC and the novel mutation and a 10-year-old girl from Kosovo who is a homozygote for the novel FANCA c.3446_3449dupCCCT mutation. The novel mutation is located in exon 35 in the FAAP20-binding domain which plays a crucial role in the FANCA-FAAP20 interaction and is required for integrity of the fanconi anemia pathway. Conclusion: The finding of the FANCA c.3446_3449dupCCCT mutation in two unrelated FA patients with Romani ethnicity from Macedonia and Kosovo suggests it is a founder mutation in the Romani population living in the Balkan region

  11. The CHEK2 del5395 is a founder mutation without direct effects for cancer risk in the latvian population

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    Plonis J

    2015-12-01

    Full Text Available Our objective was to determine: 1 whether the checkpoint kinase 2 (CHEK2 del5395 (g.27417113-27422508 del, NC_000022.11 is a founder mutation in the Latvian population, 2 if there is an association between CHEK2 del5395 mutation and cancer risk, and 3 and whether the CHEK2 del5395 mutation impacts cancer predisposition in Chernobyl disaster liquidators (the civil and military personnel who were called upon to deal with consequences of the 1986 nuclear disaster as well as geriatric populations. We recruited 438 breast cancer patients, 568 colorectal cancer patients, 399 ovarian cancer patients, 419 prostate cancer patients, 526 healthy blood donors, 480 Chernobyl disaster liquidators and 444 geriatric cancer-free participants. DNA samples were isolated from blood samples and subjected to multiplex polymerase chain reaction (PCR. The truncation of del5395 was estimated by fragment size of the multiplex PCR.All groups were compared to the healthy blood donors using Fisher’s exact test. All p values were two-sided and the odds ratios (OR calculated by two-by-two table. In cancer groups, the del5395 mutation was most frequently observed in the ovarian cancer group (1.00%, OR = 1.32. In control groups, the del5395 mutation was most frequent (0.76% in the healthy donors, which exceeded its frequency in the Chernobyl liquidators group and the geriatric group by 0.01 and 0.08%, respectively. For all groups, the OR appeared to be >1 only in ovarian cancer patients. However, OR rates showed no statistical significance in either cancer or control groups, with the p value fluctuating within the range of 0.39-1.00. The CHEK2 gene del5395 is a founder mutation in the Latvian population, which, however, does not have a direct impact on genetic predisposition toward colorectal, breast, ovarian and prostate cancer.

  12. HealthSouth's most wanted. Founder and former chairman and CEO Richard Scrushy is indicted for 85 counts of conspiracy, fraud and money laundering.

    Science.gov (United States)

    Piotrowski, Julie

    2003-11-10

    Wake-up call for the industry or an isolated case of corporate chicanery? Healthcare experts are divided on the import of Richard Scrushy's indictment on 85 counts last week in connection with the financial scandal at HealthSouth Corp. The indictment alleges the company founder relied on electronic and telephone surveillance, threats and intimidation to control his accomplices.

  13. Percecao da cultura organizacional em instituicoes publicas de saude com diferentes modelos de gestao Percepcion de la cultura organizacional en las instituciones de salud publica con diferentes modelos de gestion Perception of organizational culture in public health facilities with different management models

    Directory of Open Access Journals (Sweden)

    Sofia Gaspar Cruz

    2012-03-01

    Full Text Available Contexto: o sistema de saude portugues tem vindo a ser palco de reformas constantes sem que se tenham obtido os resultados esperados. Considerada enquanto variavel organizacional, que pode ditar o sucesso de determinada mudanca/reforma, e partindo-se do pressuposto que e gerivel, conhecer a cultura organizacional que predomina nas instituicoes de saude parece ser importante para quem as gere, principalmente perante processos de mudanca, como seja a implementacao de novos modelos de gestao. Objetivo: identificar o tipo de cultura organizacional que predomina em instituicoes publicas de saude com diferentes modelos de gestao. Metodo: estudo de tipo quantitativo e transversal, realizado numa amostra de 671 colaboradores de dez instituicoes de saude com diferentes modelos de gestao: modelo Sector Publico Administrativo (SPA, modelo Entidade Publica Empresarial (EPE e modelo Unidade de Saude Familiar (USF. Para identificar a percecao da cultura organizacional recorreu-se ao Organizational Culture Assessment Instrument (OCAI, que foi por nos traduzido, adaptado e validado. Resultados: nos modelos SPA e EPE verifica-se um predominio da cultura hierarquica, enquanto no modelo USF sobressai a cultura de cla. Conclusao: a cultura organizacional que prevalece nas instituicoes de saude, nomeadamente a nivel hospitalar (cultura hierarquica, nao parece ser a mais adequada a filosofia subjacente aos novos modelos de gestao e seu funcionamento. Considera-se pertinente alargar o estudo da percecao da cultura organizacional em cada modelo de gestao das instituicoes de saude e relacionar com variaveis de contexto.Contexto: el sistema de salud portugues ha sido el escenario de constantes reformas sin que por ello se hayan obtenido los resultados esperados. Considerada como una variable organizacional, que puede dictar el exito de un determinado cambio o reforma, y partiendo de la suposicion de que es gestionable, conocer la cultura organizacional que predomina en

  14. Nonsyndromic retinitis pigmentosa is highly prevalent in the Jerusalem region with a high frequency of founder mutations.

    Science.gov (United States)

    Sharon, Dror; Banin, Eyal

    2015-01-01

    Nonsyndromic retinitis pigmentosa (RP) is the most common inherited retinal degeneration, and prevalence of the disease has been reported in populations of American and European origin with a relatively low consanguinity rate. Our aim was to determine the prevalence of nonsyndromic RP in the Jerusalem region, which has a population of about 1 million individuals with a high rate of consanguinity. The patients' clinical data included eye exam findings (visual acuity, anterior segment, and funduscopy) as well as electroretinographic (ERG) testing results under scotopic and photopic conditions. Mutation analysis on a subgroup of patients was performed mainly with candidate gene analysis and homozygosity mapping. We evaluated the medical records of patients with degenerative retinal diseases residing in the Jerusalem region who were examined over the past 20 years in a large tertiary medical center. A total of 453 individuals affected with nonsyndromic RP were diagnosed at our center, according to funduscopic findings and ERG testing. Based on the estimated population size of 945,000 individuals who reside in the vicinity of Jerusalem, the prevalence of nonsyndromic RP in this region is 1:2,086. The prevalence of RP was higher among Arab Muslims (1:1,798) compared to Jews (1:2,230), mainly due to consanguineous marriages that are more common in the Arab Muslim population. To identify the genetic causes of RP in our cohort, we recruited 383 patients from 183 different families for genetic analysis: 70 with autosomal recessive (AR) inheritance, 15 with autosomal dominant, 86 isolate cases, and 12 with an X-linked inheritance pattern. In 64 (35%) of the families, we identified the genetic cause of the disease, and we revised the inheritance pattern of 20 isolate cases to the AR pattern; 49% of the families in our cohort had AR inheritance. Interestingly, in 42 (66%) of the genetically identified families, the cause of disease was a founder mutation. Previous studies

  15. Comprehensive population-wide analysis of Lynch syndrome in Iceland reveals founder mutations in MSH6 and PMS2

    Science.gov (United States)

    Haraldsdottir, Sigurdis; Rafnar, Thorunn; Frankel, Wendy L.; Einarsdottir, Sylvia; Sigurdsson, Asgeir; Hampel, Heather; Snaebjornsson, Petur; Masson, Gisli; Weng, Daniel; Arngrimsson, Reynir; Kehr, Birte; Yilmaz, Ahmet; Haraldsson, Stefan; Sulem, Patrick; Stefansson, Tryggvi; Shields, Peter G.; Sigurdsson, Fridbjorn; Bekaii-Saab, Tanios; Moller, Pall H.; Steinarsdottir, Margret; Alexiusdottir, Kristin; Hitchins, Megan; Pritchard, Colin C.; de la Chapelle, Albert; Jonasson, Jon G.; Goldberg, Richard M.; Stefansson, Kari

    2017-01-01

    Lynch syndrome, caused by germline mutations in the mismatch repair genes, is associated with increased cancer risk. Here using a large whole-genome sequencing data bank, cancer registry and colorectal tumour bank we determine the prevalence of Lynch syndrome, associated cancer risks and pathogenicity of several variants in the Icelandic population. We use colorectal cancer samples from 1,182 patients diagnosed between 2000–2009. One-hundred and thirty-two (11.2%) tumours are mismatch repair deficient per immunohistochemistry. Twenty-one (1.8%) have Lynch syndrome while 106 (9.0%) have somatic hypermethylation or mutations in the mismatch repair genes. The population prevalence of Lynch syndrome is 0.442%. We discover a translocation disrupting MLH1 and three mutations in MSH6 and PMS2 that increase endometrial, colorectal, brain and ovarian cancer risk. We find thirteen mismatch repair variants of uncertain significance that are not associated with cancer risk. We find that founder mutations in MSH6 and PMS2 prevail in Iceland unlike most other populations. PMID:28466842

  16. Comprehensive population-wide analysis of Lynch syndrome in Iceland reveals founder mutations in MSH6 and PMS2.

    Science.gov (United States)

    Haraldsdottir, Sigurdis; Rafnar, Thorunn; Frankel, Wendy L; Einarsdottir, Sylvia; Sigurdsson, Asgeir; Hampel, Heather; Snaebjornsson, Petur; Masson, Gisli; Weng, Daniel; Arngrimsson, Reynir; Kehr, Birte; Yilmaz, Ahmet; Haraldsson, Stefan; Sulem, Patrick; Stefansson, Tryggvi; Shields, Peter G; Sigurdsson, Fridbjorn; Bekaii-Saab, Tanios; Moller, Pall H; Steinarsdottir, Margret; Alexiusdottir, Kristin; Hitchins, Megan; Pritchard, Colin C; de la Chapelle, Albert; Jonasson, Jon G; Goldberg, Richard M; Stefansson, Kari

    2017-05-03

    Lynch syndrome, caused by germline mutations in the mismatch repair genes, is associated with increased cancer risk. Here using a large whole-genome sequencing data bank, cancer registry and colorectal tumour bank we determine the prevalence of Lynch syndrome, associated cancer risks and pathogenicity of several variants in the Icelandic population. We use colorectal cancer samples from 1,182 patients diagnosed between 2000-2009. One-hundred and thirty-two (11.2%) tumours are mismatch repair deficient per immunohistochemistry. Twenty-one (1.8%) have Lynch syndrome while 106 (9.0%) have somatic hypermethylation or mutations in the mismatch repair genes. The population prevalence of Lynch syndrome is 0.442%. We discover a translocation disrupting MLH1 and three mutations in MSH6 and PMS2 that increase endometrial, colorectal, brain and ovarian cancer risk. We find thirteen mismatch repair variants of uncertain significance that are not associated with cancer risk. We find that founder mutations in MSH6 and PMS2 prevail in Iceland unlike most other populations.

  17. The end of capitalism and its future: Hegel as founder of the concept of a welfare state

    Directory of Open Access Journals (Sweden)

    Vieweg Klaus

    2017-01-01

    Full Text Available A key part of Hegel’s practical philosophy is his theory of civil society and the idea of a rational regulation of the market. This is the foundation of Hegel’s theory of a social state. The copyright on the notion of a modern society of freedom and a rational, social state belongs to Hegel. Hegel proves himself to be the thinker who until now has provided the most convincing foundation for freedom in modernity. The theoretical foundation and at the same time bone of contention of Hegel’s political thought is to be found in his concept of ethical life (Sittlichkeit, in particular in his theory of civil society. The current shipwreck of deregulated capitalism does not mean the foundering of our journey towards a free society. Nevertheless the deficiencies and unsustainability of both traditional models - socialist collective ownership and market fundamentalism - exhibit two contradictory claims to a share of the wealth of nations. To take up Hegel’s project is, in essence, to aim at a new conception of an environmentally and socially sustainable and just society, and a corresponding world order. It is to further Hegel’s philosophy of freedom.

  18. Who were the male founders of rural Brazilian Afro-derived communities? A proposal based on three populations.

    Science.gov (United States)

    Ribeiro, Guilherme Galvarros Bueno Lobo; Abe-Sandes, Kiyoko; Barcelos, Rejane da Silva Sena; Klautau-Guimarães, Maria de Nazaré; Junior, Wilson Araujo da Silva; Oliveira, Silviene Fabiana de

    2011-03-01

    Brazilian Quilombos are Afro-derived communities founded mainly by fugitive slaves between the 16(th) and 19(th) centuries; they can be recognized today by ancestral and cultural characteristics. Each of these remnant communities, however, has its own particular history, which includes the migration of non-African derived people. The present work presents a proposal for the origin of the male founder in Brazilian quilombos based on Y-haplogroup distribution. Y haplogroups, based on 16 binary markers (92R7, SRY2627, SRY4064, SRY10831.1 and .2, M2, M3, M09, M34, M60, M89, M213, M216, P2, P3 and YAP), were analysed for 98 DNA samples from genetically unrelated men from three rural Brazilian Afro-derived communities-Mocambo, Rio das Rãs and Kalunga-in order to estimate male geographic origin. Data indicated significant differences among these communities. A high frequency of non-African haplogroups was observed in all communities. This observation suggested an admixture process that has occurred over generations and directional mating between European males and African female slaves that must have occurred on farms before the slaves escaped. This means that the admixture occurred before the slaves escaped and the foundation of the quilombo.

  19. Alfred Russel Wallace (1823-1913): the forgotten co-founder of the Neo-Darwinian theory of biological evolution.

    Science.gov (United States)

    Kutschera, Ulrich; Hossfeld, Uwe

    2013-12-01

    The British naturalist Alfred Russel Wallace (1823-1913), who had to leave school aged 14 and never attended university, did extensive fieldwork, first in the Amazon River basin (1848-1852) and then in Southeast Asia (1854-1862). Based on this experience, and after reading the corresponding scientific literature, Wallace postulated that species were not created, but are modified descendants of pre-existing varieties (Sarawak Law paper, 1855). Evolution is brought about by a struggle for existence via natural selection, which results in the adaptation of those individuals in variable populations who survive and reproduce (Ternate essay, 1858). In his monograph Darwinism (1889), and in subsequent publications, Wallace extended the contents of Darwin's Origin of Species (1859) into the Neo-Darwinian theory of biological evolution, with reference to the work of August Weismann (1834-1914). Wallace also became the (co)-founder of biogeography, biodiversity research, astrobiology and evolutionary anthropology. Moreover, he envisioned what was later called the anthropocene (i.e., the age of human environmental destructiveness). However, since Wallace believed in atheistic spiritualism and mixed up scientific facts and supernatural speculations in some of his writings, he remains a controversial figure in the history of biology.

  20. High throughput generation and characterization of replication-competent clade C transmitter-founder simian human immunodeficiency viruses.

    Directory of Open Access Journals (Sweden)

    Debashis Dutta

    Full Text Available Traditional restriction endonuclease-based cloning has been routinely used to generate replication-competent simian-human immunodeficiency viruses (SHIV and simian tropic HIV (stHIV. This approach requires the existence of suitable restriction sites or the introduction of nucleotide changes to create them. Here, using an In-Fusion cloning technique that involves homologous recombination, we generated SHIVs and stHIVs based on epidemiologically linked clade C transmitted/founder HIV molecular clones from Zambia. Replacing vif from these HIV molecular clones with vif of SIVmac239 resulted in chimeric genomes used to generate infectious stHIV viruses. Likewise, exchanging HIV env genes and introducing N375 mutations to enhance macaque CD4 binding site and cloned into a SHIVAD8-EO backbone. The generated SHIVs and stHIV were infectious in TZMbl and ZB5 cells, as well as macaque PBMCs. Therefore, this method can replace traditional methods and be a valuable tool for the rapid generation and testing of molecular clones of stHIV and SHIV based on primary clinical isolates will be valuable to generate rapid novel challenge viruses for HIV vaccine/cure studies.

  1. Generation and Characterization of HIV-1 Transmitted and Founder Virus Consensus Sequence from Intravenous Drug Users in Xinjiang, China.

    Science.gov (United States)

    Li, Fan; Ma, Liying; Feng, Yi; Hu, Jing; Ni, Na; Ruan, Yuhua; Shao, Yiming

    2017-06-01

    HIV-1 transmission in intravenous drug users (IDUs) has been characterized by high genetic multiplicity and suggests a greater challenge for HIV-1 infection blocking. We investigated a total of 749 sequences of full-length gp160 gene obtained by single genome sequencing (SGS) from 22 HIV-1 early infected IDUs in Xinjiang province, northwest China, and generated a transmitted and founder virus (T/F virus) consensus sequence (IDU.CON). The T/F virus was classified as subtype CRF07_BC and predicted to be CCR5-tropic virus. The variable region (V1, V2, and V4 loop) of IDU.CON showed length variation compared with the heterosexual T/F virus consensus sequence (HSX.CON) and homosexual T/F virus consensus sequence (MSM.CON). A total of 26 N-linked glycosylation sites were discovered in the IDU.CON sequence, which is less than that of MSM.CON and HSX.CON. Characterization of T/F virus from IDUs highlights the genetic make-up and complexity of virus near the moment of transmission or in early infection preceding systemic dissemination and is important toward the development of an effective HIV-1 preventive methods, including vaccines.

  2. Mutation screening of the HGD gene identifies a novel alkaptonuria mutation with significant founder effect and high prevalence.

    Science.gov (United States)

    Sakthivel, Srinivasan; Zatkova, Andrea; Nemethova, Martina; Surovy, Milan; Kadasi, Ludevit; Saravanan, Madurai P

    2014-05-01

    Alkaptonuria (AKU) is an autosomal recessive disorder; caused by the mutations in the homogentisate 1, 2-dioxygenase (HGD) gene located on Chromosome 3q13.33. AKU is a rare disorder with an incidence of 1: 250,000 to 1: 1,000,000, but Slovakia and the Dominican Republic have a relatively higher incidence of 1: 19,000. Our study focused on studying the frequency of AKU and identification of HGD gene mutations in nomads. HGD gene sequencing was used to identify the mutations in alkaptonurics. For the past four years, from subjects suspected to be clinically affected, we found 16 positive cases among a randomly selected cohort of 41 Indian nomads (Narikuravar) settled in the specific area of Tamil Nadu, India. HGD gene mutation analysis showed that 11 of these patients carry the same homozygous splicing mutation c.87 + 1G > A; in five cases, this mutation was found to be heterozygous, while the second AKU-causing mutation was not identified in these patients. This result indicates that the founder effect and high degree of consanguineous marriages have contributed to AKU among nomads. Eleven positive samples were homozygous for a novel mutation c.87 + 1G > A, that abolishes an intron 2 donor splice site and most likely causes skipping of exon 2. The prevalence of AKU observed earlier seems to be highly increased in people of nomadic origin. © 2014 John Wiley & Sons Ltd/University College London.

  3. A homozygous founder missense variant in arylsulfatase G abolishes its enzymatic activity causing atypical Usher syndrome in humans.

    Science.gov (United States)

    Khateb, Samer; Kowalewski, Björn; Bedoni, Nicola; Damme, Markus; Pollack, Netta; Saada, Ann; Obolensky, Alexey; Ben-Yosef, Tamar; Gross, Menachem; Dierks, Thomas; Banin, Eyal; Rivolta, Carlo; Sharon, Dror

    2018-01-04

    PurposeWe aimed to identify the cause of disease in patients suffering from a distinctive, atypical form of Usher syndrome.MethodsWhole-exome and genome sequencing were performed in five patients from three families of Yemenite Jewish origin, suffering from distinctive retinal degeneration phenotype and sensorineural hearing loss. Functional analysis of the wild-type and mutant proteins was performed in human fibrosarcoma cells.ResultsWe identified a homozygous founder missense variant, c.133G>T (p.D45Y) in arylsulfatase G (ARSG). All patients shared a distinctive retinal phenotype with ring-shaped atrophy along the arcades engirdling the fovea, resulting in ring scotoma. In addition, patients developed moderate to severe sensorineural hearing loss. Both vision and hearing loss appeared around the age of 40 years. The identified variant affected a fully conserved amino acid that is part of the catalytic site of the enzyme. Functional analysis of the wild-type and mutant proteins showed no basal activity of p.D45Y.ConclusionHomozygosity for ARSG-p.D45Y in humans leads to protein dysfunction, causing an atypical combination of late-onset Usher syndrome. Although there is no evidence for generalized clinical manifestations of lysosomal storage diseases in this set of patients, we cannot rule out the possibility that mild and late-onset symptoms may appear.GENETICS in MEDICINE advance online publication, 4 January 2018; doi:10.1038/gim.2017.227.

  4. Sobre discurso feminista em publicações: a política do Grupo Transas do Corpo About feminist discourse in publications: Grupo Transas do Corpo's politics

    Directory of Open Access Journals (Sweden)

    Joana Plaza Pinto

    2004-12-01

    Full Text Available Uma sociedade não produz uma única forma de ver a realidade. Dividida pelos interesses antagônicos dos diferentes grupos, uma sociedade produz discursos contrários entre si. Mas há alguns que predominam sobre seus contrários numa dada época, refletindo os interesses de grupos dominantes: os discursos hegemônicos. As contrapartes antagônicas desses discursos dominantes são fortemente submetidas a formas de controle e conjuradas para se passarem por enfraquecidas. Cientes desse jogo discursivo de poder, os discursos feministas proliferam sua discussão sobre a problemática de gênero, defendendo uma sociedade plural, justa e solidária, sem contudo se deixar classificar dentro de alguma tipologia normatizadora. O Grupo Transas do Corpo, ONG feminista brasileira, busca tornar visível cada vez mais a diversidade discursiva feminista e promover a voz das mulheres no campo de discurso público. Para isso, identificou a necessidade de criar espaços de produção de textos de mulheres, de forma a criar e fortalecer a capacidade de letramento das mulheres no contexto das tecnologias de escrita contemporâneas. Para atender a esses objetivos, o Transas elaborou uma política de publicações.A society doesn't yield a only way to see reality. Divided between antagonistic interests of unequal groups, a society yield discourses in contrast and opposites. However there are some discourses that surpass yours antagonistic in your age, reproducing governing groups interests: the hegemoniacal groups. The antagonistic opponent of these governing groups are strongly submit to regulations and render void of power. Aware of these discoursive game of power, feminist discourse proliferate yours ideas about gender trouble, supporting a plural, fair and reciprocal society, although it don't go in on a standard interpretation of discourses types. Transas do Corpo Group, Brazilian feminist NGO, try to make apparent more and more the unlikeness of feminist

  5. Publicações acadêmicas de pesquisas em contabilidade sobre terceiro setor no Brasil: análise do período de 2007 a 2009

    Directory of Open Access Journals (Sweden)

    Aneide Oliveira Araújo

    2011-08-01

    Full Text Available O desenvolvimento econômico, social e político mundial impulsionam constantes mudanças no modo de estruturar as organizações, sejam elas com fins lucrativos ou não. O Terceiro Setor tem a função de cumprir um papel social na mudança do ser humano, além realizar os serviços que o Estado não consegue cumprir. Pesquisas são realizadas em diversas áreas, no intuito de melhorar técnicas, identificar insucessos e auxiliar na tomada de decisões, dando uma visão ampla do que acontece sobre determinado setor ou tema. O problema para o desenvolvimento desta pesquisa foi qual a evolução da produção acadêmica da pesquisa contábil no Brasil, relacionada às organizações do Terceiro Setor no período de 2007 a 2009 a partir da pesquisa de Olak, Slomski e Alves, intitulada: As publicações acadêmicas da pesquisa contábil no Brasil, no âmbito das organizações do Terceiro Setor. O objetivo desta pesquisa é comparar se houve evolução acadêmica da pesquisa contábil no Brasil das organizações do Terceiro Setor de 2007 a 2009, tendo como parâmetro a pesquisa realizada entre os anos de 2000 a 2006. A metodologia utilizada foi bibliográfica e exploratória, e quanto à abordagem do problema a análise dos dados coletados é quantitativa. Após a análise dos resultados, conclui-se um aumento considerável nas publicações sobre o tema Terceiro Setor, onde foram identificados 32 trabalhos – 2007 a 2009 – enquanto que no período de 2000 a 2006 foram publicados 38 trabalhos. Tanto na pesquisa anterior como a atual ainda é inexpressivo as publicações em revistas (apenas 2 publicações.

  6. Fomento à publicação científica e proteção do conhecimento científico Financing of the scientific publication and protection of the scientific knowledge

    Directory of Open Access Journals (Sweden)

    Renato Santos de Oliveira Filho

    2005-01-01

    Full Text Available O trabalho científico atinge sua finalidade maior através de sua publicação. É indiscutível a importância atual das agências de fomento à pesquisa para que se possa desenvolver, finalizar e publicar os trabalhos científicos. As principais agências de fomento abordadas neste artigo são: a Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES, o Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq e a Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP. As atividades da CAPES podem ser agrupadas em quatro grandes linhas de ação: a avaliação da pós-graduação stricto sensu; b acesso e divulgação da produção científica; c investimentos na formação de recursos de alto nível no país e exterior e d promoção da cooperação científica internacional. Embora não haja uma linha direta de apoio à publicação científica, praticamente todas as ações da CAPES acabam por contribuir para a concretização de trabalhos científicos e suas publicações. O CNPq tem duas atividades básicas: o fomento à pesquisa e a formação de recursos humanos. Disponibiliza aos pesquisadores auxílio à divulgação e publicação científicas. O auxílio à editoração tem como objetivo apoiar publicações técnico-científicas nacionais, mantidas e editadas por instituição ou sociedade científica brasileira de âmbito nacional. Através do auxílio à promoção de eventos científicos, o CNPq apóia realização no país de congressos, simpósios e outros eventos similares de curta duração. O CNPq disponibiliza a Plataforma Lattes através da qual é possível preencher e acessar o Curriculum Lattes, hoje indispensável aos pesquisadores. A FAPESP financia publicação de periódicos, artigos e livros que exponham resultados originais de pesquisa realizada por pesquisador do Estado de São Paulo. Financia parcialmente a participação de pesquisadores em reuniões científicas ou

  7. Founder haplotype analysis of Fanconi anemia in the Korean population finds common ancestral haplotypes for a FANCG variant.

    Science.gov (United States)

    Park, Joonhong; Kim, Myungshin; Jang, Woori; Chae, Hyojin; Kim, Yonggoo; Chung, Nack-Gyun; Lee, Jae-Wook; Cho, Bin; Jeong, Dae-Chul; Park, In Yang; Park, Mi Sun

    2015-05-01

    A common ancestral haplotype is strongly suggested in the Korean and Japanese patients with Fanconi anemia (FA), because common mutations have been frequently found: c.2546delC and c.3720_3724delAAACA of FANCA; c.307+1G>C, c.1066C>T, and c.1589_1591delATA of FANCG. Our aim in this study was to investigate the origin of these common mutations of FANCA and FANCG. We genotyped 13 FA patients consisting of five FA-A patients and eight FA-G patients from the Korean FA population. Microsatellite markers used for haplotype analysis included four CA repeat markers which are closely linked with FANCA and eight CA repeat markers which are contiguous with FANCG. As a result, Korean FA-A patients carrying c.2546delC or c.3720_3724delAAACA did not share the same haplotypes. However, three unique haplotypes carrying c.307+1G>C, c.1066C > T, or c.1589_1591delATA, that consisted of eight polymorphic loci covering a flanking region were strongly associated with Korean FA-G, consistent with founder haplotypes reported previously in the Japanese FA-G population. Our finding confirmed the common ancestral haplotypes on the origins of the East Asian FA-G patients, which will improve our understanding of the molecular population genetics of FA-G. To the best of our knowledge, this is the first report on the association between disease-linked mutations and common ancestral haplotypes in the Korean FA population. © 2015 John Wiley & Sons Ltd/University College London.

  8. Recurrent missense mutations in TMEM43 (ARVD5) due to founder effects cause arrhythmogenic cardiomyopathies in the UK and Canada

    KAUST Repository

    Haywood, Annika

    2012-11-15

    AimsAutosomal dominant arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) (in the group of arrhythmogenic cardiomyopathies) is a common cause of sudden cardiac death in young adults. It is both clinically and genetically heterogeneous, with 12 loci (ARVC/D1-12) and eight genes identified, the majority of which encode structural proteins of cardiac desmosomes. The most recent gene identified, TMEM43, causes disease due to a missense mutation in a non-desmosomal gene (p.S358L) in 15 extended families from Newfoundland, Canada. To determine whether mutations in TMEM43 cause ARVC/D and arrhythmogenic cardiomyopathy in other populations, we fully re-sequenced TMEM43 on 143 ARVC/D probands (families) from the UK and 55 probands (from 55 families) from Newfoundland.Methods and resultsBidirectional sequencing of TMEM43 including intron-exon boundaries revealed 33 variants, the majority located in non-coding regions of TMEM43. For the purpose of validation, families of probands with rare, potentially deleterious coding variants were subjected to clinical and molecular follow-up. Three missense variants of uncertain significance (p.R28W, p.E142K, p.R312W) were located in highly conserved regions of the TMEM43 protein. One variant (p.R312W) also co-segregated with relatives showing clinical signs of disease. Genotyping and expansion of the disease-associated haplotype in subjects with the p.R312W variant from Newfoundland, Canada, and the UK suggest common ancestry.ConclusionAlthough the p.R312W variant was found in controls (3/378), identification of an ancestral disease p R312W haplotype suggests that the p.R312W variant is a pathogenic founder mutation. © 2012 The Author.

  9. Recurrent missense mutations in TMEM43 (ARVD5) due to founder effects cause arrhythmogenic cardiomyopathies in the UK and Canada

    KAUST Repository

    Haywood, Annika; Merner, Nancy D.; Hodgkinson, Kathy A.; Houston, Jim; Syrris, Petros; Booth, Valerie; Connors, Sean; Pantazis, Antonios; Quarta, Giovanni; Elliott, Perry; McKenna, William; Young, Terry Lynn

    2012-01-01

    AimsAutosomal dominant arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) (in the group of arrhythmogenic cardiomyopathies) is a common cause of sudden cardiac death in young adults. It is both clinically and genetically heterogeneous, with 12 loci (ARVC/D1-12) and eight genes identified, the majority of which encode structural proteins of cardiac desmosomes. The most recent gene identified, TMEM43, causes disease due to a missense mutation in a non-desmosomal gene (p.S358L) in 15 extended families from Newfoundland, Canada. To determine whether mutations in TMEM43 cause ARVC/D and arrhythmogenic cardiomyopathy in other populations, we fully re-sequenced TMEM43 on 143 ARVC/D probands (families) from the UK and 55 probands (from 55 families) from Newfoundland.Methods and resultsBidirectional sequencing of TMEM43 including intron-exon boundaries revealed 33 variants, the majority located in non-coding regions of TMEM43. For the purpose of validation, families of probands with rare, potentially deleterious coding variants were subjected to clinical and molecular follow-up. Three missense variants of uncertain significance (p.R28W, p.E142K, p.R312W) were located in highly conserved regions of the TMEM43 protein. One variant (p.R312W) also co-segregated with relatives showing clinical signs of disease. Genotyping and expansion of the disease-associated haplotype in subjects with the p.R312W variant from Newfoundland, Canada, and the UK suggest common ancestry.ConclusionAlthough the p.R312W variant was found in controls (3/378), identification of an ancestral disease p R312W haplotype suggests that the p.R312W variant is a pathogenic founder mutation. © 2012 The Author.

  10. Founder representation and effective population size in old versus young breeds-genetic diversity of Finnish and Nordic Spitz.

    Science.gov (United States)

    Kumpulainen, M; Anderson, H; Svevar, T; Kangasvuo, I; Donner, J; Pohjoismäki, J

    2017-10-01

    Finnish Spitz is 130-year-old breed and has been highly popular in Finland throughout its history. Nordic Spitz is very similar to Finnish Spitz by origin and use, but is a relatively recent breed with much smaller population size. To see how breed age and breeding history have influenced the current population, we performed comprehensive population genetic analysis using pedigree data of 28,119 Finnish and 9,009 Nordic Spitzes combined with genomewide single nucleotide polymorphism (SNP) data from 135 Finnish and 110 Nordic Spitzes. We found that the Finnish Spitz has undergone repeated male bottlenecks resulting in dramatic loss of genetic diversity, reflected by 20 effective founders (f a ) and mean heterozygosity (Hz) of 0.313. The realized effective population size in the breed based on pedigree analysis (N¯ec) is 168, whereas the genetic effective population size (N eg ) computed the decay of linkage disequilibrium (r 2 ) is only 57 individuals. Nordic Spitz, although once been near extinction, has not been exposed to similar repeated bottlenecks than Finnish Spitz and had f a of 27 individuals. However, due to the smaller total population size, the breed has also smaller effective population size than Finnish Spitz (N¯ec = 98 and N eg  = 49). Interestingly, the r 2 data show that the effective population size has contracted dramatically since the establishment of the breed, emphasizing the role of breed standards as constrains for the breeding population. Despite the small population size, Nordic Spitz still maintains SNP heterozygosity levels similar to mixed breed dogs (mean Hz = 0.409). Our study demonstrates that although pedigree analyses cannot provide estimates of the present diversity within a breed, the effective population sizes inferred from them correlate with the genotyping results. The genetic relationships of the northern Spitz breeds and the benefits of the open breed registry are discussed. © 2017 Blackwell Verlag GmbH.

  11. Ethical dilemmas in scientific publication: pitfalls and solutions for editors Dilemas éticos na publicação científica: dificuldades e soluções para editores

    Directory of Open Access Journals (Sweden)

    Laragh Gollogly

    2006-08-01

    Full Text Available Editors of scientific journals need to be conversant with the mechanisms by which scientific misconduct is amplified by publication practices. This paper provides definitions, ways to document the extent of the problem, and examples of editorial attempts to counter fraud. Fabrication, falsification, duplication, ghost authorship, gift authorship, lack of ethics approval, non-disclosure, 'salami' publication, conflicts of interest, auto-citation, duplicate submission, duplicate publications, and plagiarism are common problems. Editorial misconduct includes failure to observe due process, undue delay in reaching decisions and communicating these to authors, inappropriate review procedures, and confounding a journal's content with its advertising or promotional potential. Editors also can be admonished by their peers for failure to investigate suspected misconduct, failure to retract when indicated, and failure to abide voluntarily by the six main sources of relevant international guidelines on research, its reporting and editorial practice. Editors are in a good position to promulgate reasonable standards of practice, and can start by using consensus guidelines on publication ethics to state explicitly how their journals function. Reviewers, editors, authors and readers all then have a better chance to understand, and abide by, the rules of publishing.Editores de revistas científicas precisam estar atentos aos mecanismos de disseminação de condutas inadequadas no processo de publicação. Este artigo fornece definições, formas de documentar a extensão do problema e exemplos de iniciativas para conter fraudes editorias. Fabricação, falsificação, duplicação, autoria-fantasma, autoria concedida, falta de ética na aprovação de manuscritos, não-divulgação desses fatos, publicação "salami", conflitos de interesse, autocitação, submissão e publicação duplicadas, e plágio são problemas comuns. A conduta editorial inadequada

  12. Founders Online Metadata

    Data.gov (United States)

    National Archives and Records Administration — CORRESPONDENCE AND OTHER WRITINGS OF SIX MAJOR SHAPERS OF THE UNITED STATES: George Washington, Benjamin Franklin, John Adams (and family), Thomas Jefferson,...

  13. Transmitted/Founder Viruses Rapidly Escape from CD8+ T Cell Responses in Acute Hepatitis C Virus Infection.

    Science.gov (United States)

    Bull, Rowena A; Leung, Preston; Gaudieri, Silvana; Deshpande, Pooja; Cameron, Barbara; Walker, Melanie; Chopra, Abha; Lloyd, Andrew R; Luciani, Fabio

    2015-05-01

    The interaction between hepatitis C virus (HCV) and cellular immune responses during very early infection is critical for disease outcome. To date, the impact of antigen-specific cellular immune responses on the evolution of the viral population establishing infection and on potential escape has not been studied. Understanding these early host-virus dynamics is important for the development of a preventative vaccine. Three subjects who were followed longitudinally from the detection of viremia preseroconversion until disease outcome were analyzed. The evolution of transmitted/founder (T/F) viruses was undertaken using deep sequencing. CD8(+) T cell responses were measured via enzyme-linked immunosorbent spot (ELISpot) assay using HLA class I-restricted T/F epitopes. T/F viruses were rapidly extinguished in all subjects associated with either viral clearance (n = 1) or replacement with viral variants leading to establishment of chronic infection (n = 2). CD8(+) T cell responses against 11 T/F epitopes were detectable by 33 to 44 days postinfection, and 5 of these epitopes had not previously been reported. These responses declined rapidly in those who became chronically infected and were maintained in the subject who cleared infection. Higher-magnitude CD8(+) T cell responses were associated with rapid development of immune escape variants at a rate of up to 0.1 per day. Rapid escape from CD8(+) T cell responses has been quantified for the first time in the early phase of primary HCV infection. These rapid escape dynamics were associated with higher-magnitude CD8(+) T cell responses. These findings raise questions regarding optimal selection of immunogens for HCV vaccine development and suggest that detailed analysis of individual epitopes may be required. A major limitation in our detailed understanding of the role of immune response in HCV clearance has been the lack of data on very early primary infection when the transmitted viral variants successfully establish

  14. A Middle Eastern Founder Mutation Expands the Genotypic and Phenotypic Spectrum of Mitochondrial MICU1 Deficiency: A Report of 13 Patients.

    Science.gov (United States)

    Musa, Sara; Eyaid, Wafaa; Kamer, Kimberli; Ali, Rehab; Al-Mureikhi, Mariam; Shahbeck, Noora; Al Mesaifri, Fatma; Makhseed, Nawal; Mohamed, Zakkiriah; AlShehhi, Wafaa Ali; Mootha, Vamsi K; Juusola, Jane; Ben-Omran, Tawfeg

    2018-05-03

    MICU1 encodes a Ca 2+ sensing, regulatory subunit of the mitochondrial uniporter, a selective calcium channel within the organelle's inner membrane. Ca 2+ entry into mitochondria helps to buffer cytosolic Ca 2+ transients and also activates ATP production within the organelle. Mutations in MICU1 have previously been reported in 17 children from nine families with muscle weakness, fatigue, normal lactate, and persistently elevated creatine kinase, as well as variable features that include progressive extrapyramidal signs, learning disabilities, nystagmus, and cataracts. In this study, we report the clinical features of an additional 13 patients from consanguineous Middle Eastern families with recessive mutations in MICU1. Of these patients, 12/13 are homozygous for a novel founder mutation c.553C>T (p.Q185*) that is predicted to lead to a complete loss of function of MICU1, while one patient is compound heterozygous for this mutation and an intragenic duplication of exons 9 and 10. The founder mutation occurs with a minor allele frequency of 1:60,000 in the ExAC database, but in ~1:500 individual in the Middle East. All 13 of these patients presented with developmental delay, learning disability, muscle weakness and easy fatigability, and failure to thrive, as well as additional variable features we tabulate. Consistent with previous cases, all of these patients had persistently elevated serum creatine kinase with normal lactate levels, but they also exhibited elevated transaminase enzymes. Our work helps to better define the clinical sequelae of MICU1 deficiency. Furthermore, our work suggests that targeted analysis of the MICU1 founder mutation in Middle Eastern patients may be warranted.

  15. George de Hevesy (1885-1966). Discoverer of hafnium, founder of radioanalytical chemistry and X-ray fluorescence analysis and father of nuclear medicine

    International Nuclear Information System (INIS)

    Niese, Siegfried

    2017-01-01

    George de Hevesy known as discoverer of hafnium, founder of radioanalytical chemistry and X-ray fluorescence analysis and father of nuclear medicine has done important research work in inorganic, physical and radioanalytical and physiological chemistry as well as in geochemistry, radiation biology and medicine. When he must flee for political reasons from a country he must change his colleagues, his equipments, and the topic of his work. It is extremely surprising that he could receive important results under such circumstances even at an advanced age. (author)

  16. The science and art of learning about cultures: Descriptions, explanations, and reflections In conversation with Sri Sri Ravi Shankar, Founder, Art of Living

    Directory of Open Access Journals (Sweden)

    Ritu Tripathi

    2014-06-01

    Full Text Available National cultural differences pose major obstacles to global business expansion. Managers, therefore, seek to learn more about cultures. Conventional managerial learning mostly draws from descriptive scientific models which have potential drawbacks such as unidimensionality, decontextualisation, and culture-level information. Explanatory models of cultural psychology can help overcome these limitations. Further, insights from a cross-culturally fluent authority provide reflective learnings. Toward this end, I engage in a conversation with Sri Sri Ravi Shankar, the founder of the Art of Living organization, on issues related to cultural identity in the global workplace in the Indian context.

  17. The initial antibody response to HIV-1: induction of ineffective early B cell responses against GP41 by the transmitted/founder virus

    Energy Technology Data Exchange (ETDEWEB)

    Chavez, Leslie L [Los Alamos National Laboratory; Perelson, Alan [Los Alamos National Laboratory

    2008-01-01

    A window of opportunity for immune responses to extinguish HIV -1 exists from the moment of transmission through establishment of the latent pool of HIV -I-infected cells. A critical time to study the initial immune responses to the transmitted/founder virus is the eclipse phase of HIV-1 infection (time from transmission to the first appearance of plasma virus) but, to date, this period has been logistically difficult to analyze. Studies in non-human primates challenged with chimeric simianhuman immunodeficiency virus have shown that neutralizing antibodies, when present at the time of infection, can prevent virus infection.

  18. Analisis del contenido curricular de los Documentos Normativos del Programa de Ciencias en el area de biologia para la escuela superior del sistema de educacion publica de Puerto Rico: 1993-2012

    Science.gov (United States)

    Davila Montanez, Melissa

    Esta investigacion de naturaleza cualitativa se ocupo de realizar un analisis de contenido documental de los Documentos Normativos del Programa de Ciencias en el area de biologia de la escuela superior del sistema de educacion publica de Puerto Rico del periodo 1993-2012. Los documentos analizados fueron: Guia Curricular, 1995; Marco Curricular, 2003; Estandares de Excelencia, 1996, 2000 y Estandares de Contenido y Expectativas de Grado, 2007. Se indago si hubo cambios en significados en los Componentes Estructurales: Naturaleza de la ciencia, Paradigmas para la ensenanza de la ciencia, Funcion del curriculo formal, Mision de la ensenanza de la ciencia; Contenidos, destrezas y competencias, Estrategias de ensenanza y Evaluacion/Assessment del aprendizaje. El analisis sugiere que no hubo cambios sustanciales en los significados de los Componentes Estructurales. Los documentos estudiados muestran mayormente caracteristicas similares, aunque los documentos mas recientes eran mas descriptivos, explicativos y especificos.

  19. Caracterização das publicações periódicas em fonoaudiologia e neurociências: estudo sobre os tipos e temas de artigos e visibilidade na área de linguagem Periodicals' profile in speech-language and hearing pathology and neurosciences: study on types and headers of the language area articles, and their visibility

    Directory of Open Access Journals (Sweden)

    Sandrelli Virginio de Vasconcelos

    2009-03-01

    Full Text Available TEMA: caracterização das publicações periódicas em Fonoaudiologia e Neurociências: estudo sobre os tipos e temas de artigos e visibilidade na área de linguagem. OBJETIVO: caracterizar as publicações periódicas em Fonoaudiologia estudando os artigos da área de Linguagem relacionados às Neurociências no período de 2002 a 2006. CONCLUSÃO: ficou evidente um aumento crescente de publicações em Linguagem e em Neurociências nos últimos cinco anos. Contudo, o número de publicações em determinados temas como a Dislexia, a Doença de Alzheimer e o Transtorno do Déficit de Atenção / Hiperatividade ainda mostra-se resumido.BACKGROUND: periodicals' profile in speechlanguage and hearing pathology and neurosciences: study on types and headers of the language articles, and their visibility. PURPOSE: to characterize periodicals in SpeechLanguage Pathology and Hearing, studying the articles of the Language's area related to Neurosciences in the period from 2002 to 2006. CONCLUSION: increasing publication in Language and Neurosciences in the last five years has been evident. However, number of publications in certain headers, such as dyslexia, Alzheimer's disease and AttentionDeficit/Hyperactivity Disorder are still abridged.

  20. Is the c.3G>C mutation in the succinate dehydrogenase subunit D (SDHD) gene due to a founder effect in Chinese head and neck paraganglioma patients?

    Science.gov (United States)

    Zha, Yang; Chen, Xing-ming; Lam, Ching-wan; Lee, Soo-chin; Tong, Sui-fan; Gao, Zhi-qiang

    2011-08-01

    Three Chinese patients with head and neck paragangliomas have been reported to carry the c.3G>C mutation in the succinate dehydrogenase subunit D (SDHD) gene. In addition, in our hospital, two further patients were identified who have the same mutation. It is unclear whether the c.3G>C mutation in Chinese patients is a recurrent mutation or if it is due to a founder effect. We conducted haplotype analysis on these patients to answer this question. Individual case-control study. Germ-line mutations were confirmed in the patients and their families examined in this study using direct sequencing. We also constructed and analyzed haplotypes in four Chinese families. Genotype frequencies were compared to the control group. Three of four families shared the same haplotype, which rarely occurred in the control group. The last family shared a very short area on the physical map with the other three families. There is a founder effect in Chinese head and neck paraganglioma patients carrying the SDHD c.3G>C mutation. Copyright © 2011 The American Laryngological, Rhinological, and Otological Society, Inc.

  1. The size of second chambers and European assemblies / Rein Taagepera, Steven P Recchia

    Index Scriptorium Estoniae

    Taagepera, Rein, 1933-

    2002-01-01

    Autorid võrdlevad eri maade esinduskogude kodade suurust ja elanike arvu neis maades ning arutlevad, kui suur kohtade arv peaks olema Euroopa Liidu Nõukogus ja Euroopa Parlamendis. Tabelid, diagrammid

  2. Erakondade suuruse ennustamine : Skytte auhinnaloeng / Rein Taagepera ; autori tõlge

    Index Scriptorium Estoniae

    Taagepera, Rein, 1933-

    2009-01-01

    27. septembril 2008 Skytte auhinna vastuvõtu kõne ning Uppsala ülikooli peahoones peetud auhinnaloeng, kus autor selgitab, milles seisneb süvaanalüüs valimissüsteemide osa kohta esindusdemokraatias

  3. Blue eye color in humans may be caused by a perfectly associated founder mutation in a regulatory element located within the HERC2 gene inhibiting OCA2 expression

    DEFF Research Database (Denmark)

    Eiberg, Hans; Troelsen, Jesper; Boyd, Mette

    2008-01-01

    The human eye color is a quantitative trait displaying multifactorial inheritance. Several studies have shown that the OCA2 locus is the major contributor to the human eye color variation. By linkage analysis of a large Danish family, we finemapped the blue eye color locus to a 166 Kbp region...... within the HERC2 gene. By association analyses, we identified two SNPs within this region that were perfectly associated with the blue and brown eye colors: rs12913832 and rs1129038. Of these, rs12913832 is located 21.152 bp upstream from the OCA2 promoter in a highly conserved sequence in intron 86...... founder mutation in an OCA2 inhibiting regulatory element as the cause of blue eye color in humans. In addition, an LOD score of Z = 4.21 between hair color and D14S72 was obtained in the large family, indicating that RABGGTA is a candidate gene for hair color....

  4. An USH2A founder mutation is the major cause of Usher syndrome type 2 in Canadians of French origin and confirms common roots of Quebecois and Acadians

    Science.gov (United States)

    Ebermann, Inga; Koenekoop, Robert K; Lopez, Irma; Bou-Khzam, Lara; Pigeon, Renée; Bolz, Hanno J

    2009-01-01

    Congenital hearing loss affects approximately one child in 1000. About 10% of the deaf population have Usher syndrome (USH). In USH, hearing loss is complicated by retinal degeneration with onset in the first (USH1) or second (USH2) decade. In most populations, diagnostic testing is hampered by a multitude of mutations in nine genes. We have recently shown that in French Canadians from Quebec, USH1 largely results from a single USH1C founder mutation, c.216G>A (‘Acadian allele'). The genetic basis of USH2 in Canadians of French descent, however, has remained elusive. Here, we have investigated nine USH2 families from Quebec and New Brunswick (the former Acadia) by haplotype analyses of the USH2A locus and sequencing of the three known USH2 genes. Seven USH2A mutations were identified in eight patients. One of them, c.4338_4339delCT, accounts for 10 out of 18 disease alleles (55.6%). This mutation has previously been reported in an Acadian USH2 family, and it was found in homozygous state in the three Acadians of our sample. As in the case of c.216G>A (USH1C), a common haplotype is associated with c.4338_4339delCT. With a limited number of molecular tests, it will now be possible in these populations to estimate whether children with congenital hearing impairment of different degrees will develop retinal disease – with important clinical and therapeutic implications. USH2 is the second example that reveals a significant genetic overlap between Quebecois and Acadians: in contrast to current understanding, other genetic disorders present in both populations are likely based on common founder mutations as well. PMID:18665195

  5. Posterior microphthalmia and nanophthalmia in Tunisia caused by a founder c.1059_1066insC mutation of the PRSS56 gene.

    Science.gov (United States)

    Said, Mariem Ben; Chouchène, Ebtissem; Salem, Salma Ben; Daoud, Kods; Largueche, Leila; Bouassida, Walid; Benzina, Zeineb; Ayadi, Hammadi; Söderkvist, Peter; Matri, Leila; Hmani-Aifa, Mounira

    2013-10-10

    Congenital microphthalmia (CMIC) is a common developmental ocular disorder characterized by a small, and sometimes malformed, eye. Posterior microphthalmia (PM) and nanophthalmia are two rare subtypes of isolated CMIC characterized by extreme hyperopia due to short axial length and elevated lens/eye volume ratio. While nanophthalmia is associated with a reduced size in both anterior and posterior segments, PM involves a normal-size anterior chamber but a small posterior segment. Several genes encoding transcription and non-transcription regulators have been identified in different forms of CMIC. MFRP gene mutations have, for instance, been associated with nanophthalmia, and mutations in the recently identified PRSS56 gene have been linked to PM. So far, these two forms of CMIC have been associated with 9 mutations in PRSS56. Of particular interest, a c.1059_1066insC mutation has recently been reported in four Tunisian families with isolated PM and one Tunisian family with nanophthalmia. Here, we performed a genome-wide scan using a high density single nucleotide polymorphism (SNP) array 50 K in a large consanguineous Tunisian family (PM7) affected with PM and identified the same causative disease mutation. A total of 24 polymorphic markers spanning the PRSS56 gene in 6 families originating from different regions of Tunisia were analyzed to investigate the origin of the c.1059_1066insC mutation and to determine whether it arose in a common ancestor. A highly significant disease-associated haplotype, spanning across the 146 kb of the 2q37.1 chromosome, was conserved in those families, suggesting that c.1059_1066insC arose from a common founder. The age of the mutation in this haplotype was estimated to be around 1,850 years. The identification of such 'founder effects' may greatly simplify diagnostic genetic screening and lead to better prognostic counseling. © 2013 Elsevier B.V. All rights reserved.

  6. An USH2A founder mutation is the major cause of Usher syndrome type 2 in Canadians of French origin and confirms common roots of Quebecois and Acadians.

    Science.gov (United States)

    Ebermann, Inga; Koenekoop, Robert K; Lopez, Irma; Bou-Khzam, Lara; Pigeon, Renée; Bolz, Hanno J

    2009-01-01

    Congenital hearing loss affects approximately one child in 1000. About 10% of the deaf population have Usher syndrome (USH). In USH, hearing loss is complicated by retinal degeneration with onset in the first (USH1) or second (USH2) decade. In most populations, diagnostic testing is hampered by a multitude of mutations in nine genes. We have recently shown that in French Canadians from Quebec, USH1 largely results from a single USH1C founder mutation, c.216G>A ('Acadian allele'). The genetic basis of USH2 in Canadians of French descent, however, has remained elusive. Here, we have investigated nine USH2 families from Quebec and New Brunswick (the former Acadia) by haplotype analyses of the USH2A locus and sequencing of the three known USH2 genes. Seven USH2A mutations were identified in eight patients. One of them, c.4338_4339delCT, accounts for 10 out of 18 disease alleles (55.6%). This mutation has previously been reported in an Acadian USH2 family, and it was found in homozygous state in the three Acadians of our sample. As in the case of c.216G>A (USH1C), a common haplotype is associated with c.4338_4339delCT. With a limited number of molecular tests, it will now be possible in these populations to estimate whether children with congenital hearing impairment of different degrees will develop retinal disease - with important clinical and therapeutic implications. USH2 is the second example that reveals a significant genetic overlap between Quebecois and Acadians: in contrast to current understanding, other genetic disorders present in both populations are likely based on common founder mutations as well.

  7. A founder mutation in LEPRE1 carried by 1.5% of West Africans and 0.4% of African Americans causes lethal recessive osteogenesis imperfecta.

    Science.gov (United States)

    Cabral, Wayne A; Barnes, Aileen M; Adeyemo, Adebowale; Cushing, Kelly; Chitayat, David; Porter, Forbes D; Panny, Susan R; Gulamali-Majid, Fizza; Tishkoff, Sarah A; Rebbeck, Timothy R; Gueye, Serigne M; Bailey-Wilson, Joan E; Brody, Lawrence C; Rotimi, Charles N; Marini, Joan C

    2012-05-01

    Deficiency of prolyl 3-hydroxylase 1, encoded by LEPRE1, causes recessive osteogenesis imperfecta (OI). We previously identified a LEPRE1 mutation exclusively in African Americans and contemporary West Africans. We hypothesized that this allele originated in West Africa and was introduced to the Americas with the Atlantic slave trade. We aimed to determine the frequency of carriers for this mutation among African Americans and West Africans, and the mutation origin and age. Genomic DNA was screened for the mutation using PCR and restriction digestion, and a custom TaqMan genomic single-nucleotide polymorphism assay. The mutation age was estimated using microsatellites and short tandem repeats spanning 4.2 Mb surrounding LEPRE1 in probands and carriers. Approximately 0.4% (95% confidence interval: 0.22-0.68%) of Mid-Atlantic African Americans carry this mutation, estimating recessive OI in 1/260,000 births in this population. In Nigeria and Ghana, 1.48% (95% confidence interval: 0.95-2.30%) of unrelated individuals are heterozygous carriers, predicting that 1/18,260 births will be affected with recessive OI, equal to the incidence of de novo dominant OI. The mutation was not detected in Africans from surrounding countries. All carriers shared a haplotype of 63-770 Kb, consistent with a single founder for this mutation. Using linkage disequilibrium analysis, the mutation was estimated to have originated between 650 and 900 years before present (1100-1350 CE). We identified a West African founder mutation for recessive OI in LEPRE1. Nearly 1.5% of Ghanians and Nigerians are carriers. The estimated age of this allele is consistent with introduction to North America via the Atlantic slave trade (1501-1867 CE).

  8. 9 July 2008 - Microsoft Co-Founder P. Allen visiting ATLAS control room and underground experimental area with Adviser J. Ellis and IT Department Head W. von Rüden.

    CERN Multimedia

    Maximilien Brice

    2008-01-01

    9 July 2008 - Microsoft Co-Founder P. Allen visiting ATLAS control room and underground experimental area with Adviser J. Ellis and IT Department Head W. von Rüden and guided by ATLAS Collaboration Users S. Goldfarb, P. Nevski and L. Price.

  9. Preparando o despertar de Lilith: a enfermagem no feminino retratada pelas publicações da REBEn durante as décadas de oitenta e noventa do século XX

    Directory of Open Access Journals (Sweden)

    Lucia Helena Rodrigues Costa

    2002-02-01

    Full Text Available Este estudo apresenta um levantamento das publicações da Revista Brasileira de Enfermagem/REBEn durante as décadas de 80 e 90 do século XX relativas especificamente 'as condições da mulher e/ou mulher/enfermeira. Inicialmente pensei em levantar apenas os artigos que apresentassem alguma referência à gênero, mas percebi que desde o início dos anos oitenta alguns artigos já apontavam na direção da problemática que envolve as mulheres socialmente e as implicações dessa problemática para o exercício da enfermagem, sem no entanto utilizar especificamente a categoria gênero. Assim, optei por uma avaliação dos resumos e conteúdos dos artigos no sentido de detectar todos aqueles pertinentes à essa área de interesse. Foram selecionados 11 artigos e dois editoriais temáticos que inserem a REBEn ( embora num primeiro momento pareça uma inserção tímida efetivamente como revista contextualizada com os momentos decisivos do movimento das mulheres a nível mundial.

  10. Maracujá-doce: o autor, a obra e a data da publicação de Passiflora alata (Passifloraceae Sweet-passion-fruit: the autor, data and publication of the scientific name of Passiflora alata (Passifloraceae

    Directory of Open Access Journals (Sweden)

    Luís Carlos Bernacci

    2003-08-01

    Full Text Available O maracujazeiro-doce (Passiflora alata Curtis é uma espécie nativa da América do Sul, especialmente do Brasil, cujo cultivo tem se expandido em função do preço alcançado pelos frutos. Vários trabalhos de pesquisa foram realizados com esta espécie, quase todos com imprecisões na citação do nome científico. Com o objetivo de avaliar a extensão desses equívocos e identificar a forma cientificamente correta de citar a espécie, foram investigados o autor e a data de publicação do nome científico do maracujá-doce, em estudos taxonômicos. Concluiu-se que a espécie deve ser citada como Passiflora alata Curtis, conforme publicado originalmente em 1788, no periódico Botanical Magazine.The author, data and publication of the scientific name of the sweet passion-fruit had been investigated. A series of mistakes occurred in relation to the correct citation of the species. The aim of the present paper was to evaluate the problems and identify the scientific correct form of Passiflora alata nomenclature. The species must be cited as Passiflora alata Curtis and was published originally in 1788, in the Botanical Magazine.

  11. Mineração de texto aplicada às publicações científicas sobre gestão do conhecimento no período de 2003 a 2012

    Directory of Open Access Journals (Sweden)

    Cicero Aparecido Bezerra

    Full Text Available Desde sua apresentação, em meados da década de 1980, o tema 'Gestão do Conhecimento' (GC tem sido abordado sob os mais diversos aspectos. Neste sentido, uma vez observado o aumento da quantidade de trabalhos publicados em bases acadêmicas, nos últimos 10 anos, os objetivos da presente pesquisa são (1 encontrar os termos mais empregados nestes trabalhos e as (2 diferenças entre os termos encontrados em publicações brasileiras e estrangeiras. Para isto, empregou-se a técnica de mineração de textos. Os resultados mostram que temas envolvendo práticas, processos, sistemas de GC e tecnologias de informação são recorrentemente encontrados tanto em resumos de artigos nacionais como internacionais. Por outro lado, de maneira geral, os artigos nacionais se distinguem pelo fato de apresentarem termos mais associados a aspectos abstratos da GC (modelos, conhecimento tácito e organizacional, enquanto que os internacionais caracterizam-se por termos mais pragmáticos (efetividade, implementação, relacionamentos e desenvolvimento.

  12. A novel FKRP-related muscular dystrophy founder mutation in South African Afrikaner patients with a phenotype suggestive of a dystrophinopathy

    Directory of Open Access Journals (Sweden)

    M M Mudau

    2017-01-01

    Full Text Available Background. Fukutin-related protein (FKRP muscular dystrophy is an autosomal recessive disorder caused by mutations in the FKRP gene. The condition is often misdiagnosed as a dystrophinopathy. A previously unreported mutation, c.1100T>C in exon 4 of FKRP, had been identified in homozygous form in two white South African (SA Afrikaner patients clinically diagnosed with a dystrophinopathy. Objectives. To investigate whether the c.1100T>C mutation and the common European FKRP mutation c.826C>A are present in other patients of Afrikaner origin with suspected dystrophinopathy, and whether a founder haplotype exists. Methods. The c.1100T>C mutation was initially tested for using an amplification refractory mutation system technique in 45 white SA Afrikaner patients who had tested negative using multiplex ligation probe amplification screening for exonic deletions/duplications in the dystrophin gene. Sequencing analysis was used to confirm the c.1100T>C mutation and screen for the c.826C>A mutation. Two cohorts (each numbering 100 of Afrikaans and other white controls were screened for the c.1100T>C and c.826C>A mutations, respectively. Results. Of the 45 patients, 8 patients (17.8% were homozygous for c.1100T>C, 2 (4.4% were compound heterozygotes for c.1100T>C and c.826C>A, and 1 (2.2% was heterozygous for c.1100T>C with a second unidentified mutation. The c.1100T>C mutation was found in 1/100 controls, but no heterozygotes for the c.826C>A mutation were identified. Linked marker analysis for c.1100T>C showed a common haplotype, suggesting a probable founder mutation in the SA Afrikaner population. Conclusion. FKRP mutations may be relatively common in Afrikaners, and screening should be considered in patients who have a suggestive phenotype and test negative for a dystrophinopathy. This test will be useful for offering diagnostic, carrier and prenatal testing for affected individuals and their families. As FKRP muscular dystrophy is autosomal

  13. Fifty-five years (1955-2010) of the Coagulation Section at Laboratory of Hematology, Sestre milosrdnice University Hospital, and its founder, hematologist Ljubomir Popović.

    Science.gov (United States)

    Stancić, Vladimir; Stancić, Nevenka; Vucelić, Vesna; Lang, Nada; Grbac, Ljiljana

    2011-09-01

    The Coagulation Section at Laboratory of Hematology, Sestre milosrdnice University Hospital, Zagreb, was founded in 1955 by Ljubomir Popović, hematologist and assistant at School of Medicine, University of Zagreb, in cooperation with hard-working laboratory technicians. Apart from papers on hematologic neoplasms, plasmacytoma and lymphoma, Ljubomir Popović published a number of papers in the field of anticoagulant therapy with heparin and oral anticoagulants, some of which are also in use today. After Ljubomir Popović left the Hospital in 1964, the Laboratory was run by Professor Nedjeljko Milić, head of the newly founded Division of Hematology. In 1968, the management of the Laboratory of Hematology was taken over by Biserka Raić, MS, medical biochemist, until her retirement in 2007. Great development in morphological and cytometric studies of blood and blood cells has been paralleled by continuous progress and almost dominating activities in the diagnosis of hemostasis disorders. In the 1970s, Marko Koprcina, hematologist, and Biserka Raić introduced the then latest tests in practice at all Hospital departments. In that golden age of the Coagulation Section, M. Koprcina, B. Raić and their associates transferred their knowledge to all colleagues in the Hospital. Through that collaboration, high standards in the diagnosis of hemostasis disorders were achieved, from which the currently high level of clinical knowledge about coagulation disorders and their treatment has derived, making Sestre milosrdnice University Hospital one of the leading hospitals in this field in the country. By describing development of the Coagulation Section and the life of its founder Ljubomir Popović, the authors tried to provide an answer to the following question: can today's clinicians still have a deciding role in laboratory development, considering that assessments of different phenomena are always initiated by an interested clinician who is trying to interpret and understand

  14. TP53 mutations in ovarian carcinomas from sporadic cases and carriers of two distinct BRCA1 founder mutations; relation to age at diagnosis and survival

    International Nuclear Information System (INIS)

    Kringen, Pedro; Wang, Yun; Dumeaux, Vanessa; Kristensen, Gunnar; Borresen-Dale, Anne-Lise; Dorum, Anne

    2005-01-01

    Ovarian carcinomas from 30 BRCA1 germ-line carriers of two distinct high penetrant founder mutations, 20 carrying the 1675delA and 10 the 1135insA, and 100 sporadic cases were characterized for somatic mutations in the TP53 gene. We analyzed differences in relation to BRCA1 germline status, TP53 status, survival and age at diagnosis, as previous studies have not been conclusive. DNA was extracted from paraffin embedded formalin fixed tissues for the familial cases, and from fresh frozen specimen from the sporadic cases. All cases were treated at our hospital according to protocol. Mutation analyses of exon 2 – 11 were performed using TTGE, followed by sequencing. Survival rates for BRCA1-familial cases with TP53 mutations were not significantly lower than for familial cases without TP53 mutations (p = 0.25, RR = 1.64, 95% CI [0.71–3.78]). Median age at diagnosis for sporadic (59 years) and familial (49 years) cases differed significantly (p < 0.001) with or without TP53 mutations. Age at diagnosis between the two types of familial carriers were not significantly different, with median age of 47 for 1675delA and 52.5 for 1135insA carriers (p = 0.245). For cases ≥50 years at diagnosis, a trend toward longer survival for sporadic over familial cases was observed (p = 0.08). The opposite trend was observed for cases <50 years at diagnosis. There do not seem to be a protective advantage for familial BRCA1 carriers without TP53 mutations over familial cases with TP53 mutations. However, there seem to be a trend towards initial advantage in survival for familial cases compared to sporadic cases diagnosed before the age of 50 both with and without TP53 mutations. However, this trend diminishes over time and for cases diagnosed ≥50 years the sporadic cases show a trend towards an advantage in survival over familial cases. Although this data set is small, if confirmed, this may be a link in the evidence that the differences in ovarian cancer survival reported, are

  15. The initiation of lateral roots in the primary roots of maize (Zea mays L.) implies a reactivation of cell proliferation in a group of founder pericycle cells.

    Science.gov (United States)

    Alarcón, M Victoria; Lloret, Pedro G; Martín-Partido, Gervasio; Salguero, Julio

    2016-03-15

    The initiation of lateral roots (LRs) has generally been viewed as a reactivation of proliferative activity in pericycle cells that are committed to initiate primordia. However, it is also possible that pericycle founder cells that initiate LRs never cease proliferative activity but rather are displaced to the most distal root zones while undertaking successive stages of LR initiation. In this study, we tested these two alternative hypotheses by examining the incorporation of 5-bromo-2'-deoxyuridine (BrdU) into the DNA of meristematic root cells of Zea mays. According to the values for the length of the cell cycle and values for cell displacement along the maize root, our results strongly suggest that pericycle cells that initiate LR primordia ceased proliferative activity upon exiting the meristematic zone. This finding is supported by the existence of a root zone between 4 and 20mm from the root cap junction, in which neither mitotic cells nor labelled nuclei were observed in phloem pericycle cells. Copyright © 2016 Elsevier GmbH. All rights reserved.

  16. Novel NTRK1 mutations cause hereditary sensory and autonomic neuropathy type IV: demonstration of a founder mutation in the Turkish population.

    Science.gov (United States)

    Tüysüz, Beyhan; Bayrakli, Fatih; DiLuna, Michael L; Bilguvar, Kaya; Bayri, Yasar; Yalcinkaya, Cengiz; Bursali, Aysegul; Ozdamar, Elif; Korkmaz, Baris; Mason, Christopher E; Ozturk, Ali K; Lifton, Richard P; State, Matthew W; Gunel, Murat

    2008-05-01

    Hereditary sensory and autonomic neuropathy type IV (HSAN IV), or congenital insensitivity to pain with anhidrosis, is an autosomal recessive disorder characterized by insensitivity to noxious stimuli, anhidrosis from deinnervated sweat glands, and delayed mental and motor development. Mutations in the neurotrophic tyrosine kinase receptor type 1 (NTRK1), a receptor in the neurotrophin signaling pathway phosphorylated in response to nerve growth factor, are associated with this disorder. We identified six families from Northern Central Turkey with HSAN IV. We screened the NTRK1 gene for mutations in these families. Microsatellite and single nucleotide polymorphism (SNP) markers on the Affymetrix 250K chip platform were used to determine the haplotypes for three families harboring the same mutation. Screening for mutations in the NTRK1 gene demonstrated one novel frameshift mutation, two novel nonsense mutations, and three unrelated kindreds with the same splice-site mutation. Genotyping of the three families with the identical splice-site mutation revealed that they share the same haplotype. This report broadens the spectrum of mutations in NTRK1 that cause HSAN IV and demonstrates a founder mutation in the Turkish population.

  17. The History of the Foundation of the Iranian National Blood Transfusion Service in 1974 and the Biography of its Founder; Professor Fereydoun Ala.

    Science.gov (United States)

    Azizi, Mohammad Hossein; Nayernouri, Touraj; Bahadori, Moslem

    2015-06-01

    The history of early attempts of blood transfusion in Iran traces back to the 1940s; however, around three decades later in 1974, the Iranian National Blood Transfusion Service (Sazeman-e Melli-e Enteqal-e Khun-e Iran) was founded by the outstanding hematologist, Professor Fereydoun Ala. The main goals of this centralized organization were to collect blood from healthy voluntary donors, to screen the donated blood and to provide various safe blood products based on scientific and ethical standards. In due course, a new era of blood transfusion service in Iran had begun to such a degree that after more than four decades of its activity, it is now considered the best-developed blood service in the eastern Mediterranean region. Here, a brief historical account of the early blood transfusion efforts and the establishment of the modern Iranian National Blood Transfusion Service in Iran is discussed in addition to the life and career of its founder and first director, Professor Fereydoun Ala.

  18. Eduardo Primo Yúfera, founder of Revista de Agroquímica y Tecnología de Alimentos and pioneer on food science and technology research in Spain.

    Science.gov (United States)

    Ayala-Gascón, M; Aleixandre-Benavent, R; Gandía-Balaguer, A

    2011-12-01

    Eduardo Primo Yúfera was the founder and director of the Instituto de Agroquímica y Tecnología de Alimentos (IATA, 1957-1974) until he was appointed president of the Consejo Superior de Investigaciones Científicas (CSIC). His aim to publicize food science led him to create the Revista de Agroquímica y Tecnología de Alimentos in 1961, the forerunner of this journal, Food Science and Technology International, which he directed until 1977. Of his scientific output, 50% has been published in this journal. He is considered to be the promoter and exponent of Food Science and Technology and Chemical Ecology in Spain as well as the instigator of the country's innovation model (R&D and innovation). In his work, he was able to combine basic research excellence and socially relevant applied research to move both science and society forward. He was an example and inspiration to many colleagues and followers. The aim of this study is to highlight the influence and importance of Primo Yúfera in the formation, development and consolidation of the journal Revista de Agroquímica y Tecnología de Alimentos, and to appraise his scientific contribution to this journal.

  19. BRCA Genetic Screening in Middle Eastern and North African: Mutational Spectrum and Founder BRCA1 Mutation (c.798_799delTT in North African

    Directory of Open Access Journals (Sweden)

    Abdelilah Laraqui

    2015-01-01

    Full Text Available Background. The contribution of BRCA1 mutations to both hereditary and sporadic breast and ovarian cancer (HBOC has not yet been thoroughly investigated in MENA. Methods. To establish the knowledge about BRCA1 mutations and their correlation with the clinical aspect in diagnosed cases of HBOC in MENA populations. A systematic review of studies examining BRCA1 in BC women in Cyprus, Jordan, Egypt, Lebanon, Morocco, Algeria, and Tunisia was conducted. Results. Thirteen relevant references were identified, including ten studies which performed DNA sequencing of all BRCA1 exons. For the latter, 31 mutations were detected in 57 of the 547 patients ascertained. Familial history of BC was present in 388 (71% patients, of whom 50 were mutation carriers. c.798_799delTT was identified in 11 North African families, accounting for 22% of total identified BRCA1 mutations, suggesting a founder allele. A broad spectrum of other mutations including c.68_69delAG, c.181T>G, c.5095C>T, and c.5266dupC, as well as sequence of unclassified variants and polymorphisms, was also detected. Conclusion. The knowledge of genetic structure of BRCA1 in MENA should contribute to the assessment of the necessity of preventive programs for mutation carriers and clinical management. The high prevalence of BC and the presence of frequent mutations of the BRCA1 gene emphasize the need for improving screening programs and individual testing/counseling.

  20. Human mtDNA hypervariable regions, HVR I and II, hint at deep common maternal founder and subsequent maternal gene flow in Indian population groups.

    Science.gov (United States)

    Sharma, Swarkar; Saha, Anjana; Rai, Ekta; Bhat, Audesh; Bamezai, Ramesh

    2005-01-01

    We have analysed the hypervariable regions (HVR I and II) of human mitochondrial DNA (mtDNA) in individuals from Uttar Pradesh (UP), Bihar (BI) and Punjab (PUNJ), belonging to the Indo-European linguistic group, and from South India (SI), that have their linguistic roots in Dravidian language. Our analysis revealed the presence of known and novel mutations in both hypervariable regions in the studied population groups. Median joining network analyses based on mtDNA showed extensive overlap in mtDNA lineages despite the extensive cultural and linguistic diversity. MDS plot analysis based on Fst distances suggested increased maternal genetic proximity for the studied population groups compared with other world populations. Mismatch distribution curves, respective neighbour joining trees and other statistical analyses showed that there were significant expansions. The study revealed an ancient common ancestry for the studied population groups, most probably through common founder female lineage(s), and also indicated that human migrations occurred (maybe across and within the Indian subcontinent) even after the initial phase of female migration to India.

  1. A deep intronic CLRN1 (USH3A) founder mutation generates an aberrant exon and underlies severe Usher syndrome on the Arabian Peninsula.

    Science.gov (United States)

    Khan, Arif O; Becirovic, Elvir; Betz, Christian; Neuhaus, Christine; Altmüller, Janine; Maria Riedmayr, Lisa; Motameny, Susanne; Nürnberg, Gudrun; Nürnberg, Peter; Bolz, Hanno J

    2017-05-03

    Deafblindness is mostly due to Usher syndrome caused by recessive mutations in the known genes. Mutation-negative patients therefore either have distinct diseases, mutations in yet unknown Usher genes or in extra-exonic parts of the known genes - to date a largely unexplored possibility. In a consanguineous Saudi family segregating Usher syndrome type 1 (USH1), NGS of genes for Usher syndrome, deafness and retinal dystrophy and subsequent whole-exome sequencing each failed to identify a mutation. Genome-wide linkage analysis revealed two small candidate regions on chromosome 3, one containing the USH3A gene CLRN1, which has never been associated with Usher syndrome in Saudi Arabia. Whole-genome sequencing (WGS) identified a homozygous deep intronic mutation, c.254-649T > G, predicted to generate a novel donor splice site. CLRN1 minigene-based analysis confirmed the splicing of an aberrant exon due to usage of this novel motif, resulting in a frameshift and a premature termination codon. We identified this mutation in an additional two of seven unrelated mutation-negative Saudi USH1 patients. Locus-specific markers indicated that c.254-649T > G CLRN1 represents a founder allele that may significantly contribute to deafblindness in this population. Our finding underlines the potential of WGS to uncover atypically localized, hidden mutations in patients who lack exonic mutations in the known disease genes.

  2. Perfil da publicação científica brasileira sobre a temática da classe hospitalar Profile of Brazilian scientific publications on the subject of hospital shooling

    Directory of Open Access Journals (Sweden)

    Alessandra Santana Soares e Barros

    2011-08-01

    Full Text Available O objetivo do trabalho foi descrever o perfi l da publicação científi ca brasileira sobre a temática da escolarização em hospitais, iniciativa justifi cada a partir do reconhecimento da importância da produção científi ca na legitimação e consolidação de uma nova área do saber. Foram analisados 47 artigos publicadosem periódicos científi cos entre os anos de 1997 e 2008. Tratou-se, basicamente, de um estudo de avaliação do Estado do Conhecimento (ou Estado da Arte de uma área de interesse crescente dentro da Educação Especial: a escolarização de crianças hospitalizadas e/ou doentes crônicas, designada pelo MEC segundo o termo Classe Hospitalar. Do ponto de vista do corpus empírico, tratou-se de uma pesquisa documental, alicerçada metodologicamente na Análise de Conteúdo. Os artigos da amostra foram quantifi cados e qualifi cados segundo o tipo de investimento empírico predominante, quais fossem: ensaio, relato de experiência, relatos de pesquisa original (pesquisa com desenho de investigação ou revisão de literatura. Buscou-se, também, identifi car se o periódico ao qual o artigo pertencia encontrava-se indexado em bases de dados: SciELO, Edubase, Bireme e catálogo do INEP. Descreveu-se, ainda, a distribuição dos artigos por área de conhecimento e por instituições de onde provinham. Os principais resultados obtidos revelaram que dos 47 artigos analisados 22 foram classifi cados como sendo oriundos de pesquisa original, apenas dois periódicos encontravam-se indexados em todas as bases de dados consideradas em relevância e as publicações foram originadas, em sua grande parte, da atividade de pesquisadores estabelecidos em instituições federais de ensino superior.The aim of this paper was to describe the profi le of Brazilian scientifi c publications on the topic of education in hospitals, an initiative justifi ed since the recognition of the importance of scientifi c output in legitimizing and

  3. Ethical dilemmas experienced by nurses presented in nursing publications Dilemas éticos vivenciados por enfermeros y presentados en publicaciones de enfermería Dilemas éticos vivenciados por enfermeiros apresentados em publicações de enfermagem

    Directory of Open Access Journals (Sweden)

    Maria Adelane Alves Monteiro

    2008-12-01

    sentido de contribuir para el cambio de actitud, que implicaría en mejorar la calidad de la práctica profesional.Trata-se de revisão sistemática da literatura, realizada em artigos da área da enfermagem, contidos no banco de dados SCIELO, e que abordaram o tema "ética". Teve como objetivo identificar os dilemas éticos da enfermagem a partir de revisão de literatura em publicações da área, no período de 2002 a 2006. Localizou-se quarenta publicações, das quais foram selecionadas dezessete. A análise dos artigos permitiu a organização das categorias: ética, o sistema de saúde e a prática de enfermagem, ética e o ensino-aprendizagem na enfermagem, ética e o cuidado de enfermagem. Percebeu-se que os autores atribuíram às questões éticas abordagem multidimensional, no entanto, considerou-se, aqui, necessária maior atenção a respeito dos aspectos éticos que permeiam a prática de enfermagem. Ficou clara a necessidade de mais estudos que evidenciem novos dilemas éticos vivenciados por enfermeiros, no sentido de contribuir para mudança de atitude, implicando na qualidade da prática profissional.

  4. Mapping of epistemological approaches on publications on the organizational strategy field Mapeamento de abordagens epistemológicas em publicações sobre estratégia organizacional

    Directory of Open Access Journals (Sweden)

    Renê Birochi

    2013-03-01

    Full Text Available This paper aims to conduct a study about the major epistemological approaches, identified in articles on the subject of organizational strategy. The theoretical framework that guided this research is based on the classical definition proposed by Burrell and Morgan (1979 about the four paradigms of social science research. We investigated articles in the area of Administration, Accounting and Tourism, published in Brazilian journals between the years 2001 to 2012, classified as "B1" and "B2" in accordance with Qualis / CAPES criteria. In order to meet this goal, we performed a bibliometric study to map the selected publications. As a result of this study, there was a predominance of the functionalist paradigm, as well as a reduced presence of articles which explain their theoretical and methodological choices as the foundation for their empirical studies.Este artigo tem como objetivo realizar um estudo sobre as principais abordagens epistemológicas, identificadas em artigos sobre o tema da estratégia organizacional. O referencial teórico que guiou esta investigação é baseado na clássica definição proposta por Burrell e Morgan (1979 a respeito dos quatro paradigmas de pesquisa em ciências sociais. Foram investigados artigos da área de Administração, Ciências Contábeis e Turismo, publicados em periódicos nacionais entre os anos de 2001 a 2012, nos estratos B1 e B2 do sistema Qualis/Capes. Visando a atender este objetivo, foi realizado um estudo bibliométrico para mapear as publicações selecionadas. Como resultado deste estudo, constatou-se a predominância do paradigma funcionalista, assim como uma reduzida presença de artigos que explicitam as suas escolhas teórico-metodológicas, como fundamento para seus estudos empíricos. 

  5. Writing for international publication in nursing journals: a personal perspective (part 1 Como escribir para publicacion en enfermeria: una perspectiva personal (parte 1 Como escrever para publicação internacional em enfermagem: uma perspectiva pessoal (parte 1

    Directory of Open Access Journals (Sweden)

    G. Hussein Rassool

    2006-04-01

    . Nuestro desafío en América Latina es fomentar el desarrollo de artículos para publicación impresa o no en revistas con revisores internacionales. La co-autoría ofrece un modelo potencialmente alentador tanto para el investigador como para el alumno de postgrado publicar. Esa tarea puede ser emprendida con la ayuda de supervisores internacionales e investigadores o estudiantes de postgrado que dominan la lengua inglesa. Este artículo intenta desvelar el proceso de publicación y presentar algunos principios directivos de como publicar en revistas internacionales.O número de meios de divulgação acadêmica impressa e eletrônica (Internet de enfermagem de abrangência nacional e internacional destaca a importância de publicar entre enfermeiros. Ao redor do mundo, as revistas estão sendo categorizadas em relação a méritos para a profissão e avaliação por pares. Cada vez mais, as instituições de financiamento de pesquisa estão atentas à publicação em revistas de prestígio acadêmico como um dos critérios para a concessão do mesmo. Um fator importante a ser considerado entre as razões para que muitos artigos científicos falham no preenchimento dos requisitos de avaliação dos revisores de revistas internacionais, principalmente aquelas de idioma inglês, é a tradução pobre e de modo literal. Nosso desafio na América Latina é incrementar o desenvolvimento de artigos para publicação impressa ou não em revistas com revisores internacionais. A co-autoria oferece um modelo potencialmente encorajador tanto para o pesquisador como para o pós-graduando publicar. Esse objetivo pode ser empreendido com a ajuda de supervisores internacionais e pesquisadores, orientadores ou estudantes de pós-graduação conhecedores da língua inglesa. O presente artigo busca desmistificar o processo de publicação e apresentar alguns princípios norteadores de como publicar em revistas internacionais.

  6. Writing for international publication in nursing journals: a personal perspective (Part 2 Como escribir para publicacion en enfermeria: una perspectiva personal (Parte 2 Como escrever para publicação internacional em enfermagem: uma perspectiva pessoal (Parte 2

    Directory of Open Access Journals (Sweden)

    G. Hussein Rassool

    2006-06-01

    . Nuestro desafío en América Latina es fomentar el desarrollo de artículos para publicación impresa o no en revistas con revisores internacionales. La co-autoría ofrece un modelo potencialmente alentador tanto para el investigador como para el alumno de postgrado publicar. Esa tarea puede ser emprendida con la ayuda de supervisores internacionales e investigadores o estudiantes de postgrado que dominan la lengua inglesa. Este artículo intenta desvelar el proceso de publicación y presentar algunos principios directivos de como publicar en revistas internacionales.O número de meios de divulgação acadêmica impressa e eletrônica (Internet de enfermagem de abrangência nacional e internacional destaca a importância de publicar entre enfermeiros. Ao redor do mundo, as revistas estão sendo categorizadas em relação a méritos para a profissão e avaliação por pares. Cada vez mais, as instituições de financiamento de pesquisa estão atentas à publicação em revistas de prestígio acadêmico como um dos critérios para a concessão do mesmo. Um fator importante a ser considerado entre as razões para que muitos artigos científicos falham no preenchimento dos requisitos de avaliação dos revisores de revistas internacionais, principalmente aquelas de idioma inglês, é a tradução pobre e de modo literal. Nosso desafio na América Latina é incrementar o desenvolvimento de artigos para publicação impressa ou não em revistas com revisores internacionais. A co-autoria oferece um modelo potencialmente encorajador tanto para o pesquisador como para o pós-graduando publicar. Esse objetivo pode ser empreendido com a ajuda de supervisores internacionais e pesquisadores, orientadores ou estudantes de pós-graduação conhecedores da língua inglesa. O presente artigo busca desmistificar o processo de publicação e apresentar alguns princípios norteadores de como publicar em revistas internacionais.

  7. Interview with Mia Katigbak (co-founder and artistic producing director of NAATCO).Breaking Racial and Ethnic Stereotypes on the American Stage: National Asian American Theatre Company’s 25th Anniversary

    OpenAIRE

    Medalle, Rovie Herrera

    2016-01-01

    Entretien avec Mia Katigbak, co-fondatrice et directrice artistique de NAATCO (National Asian American Theatre Company). L’entretien, réalisé en août 2015, consistaient en un échange de courriels Interview with Mia Katigbak, co-founder and Artistic Producing Director of NAATCO (National Asian American Theatre Company). The interview was conducted by emails in August 2015

  8. The roles of geography and founder effects in promoting host-associated differentiation in the generalist bogus yucca moth Prodoxus decipiens.

    Science.gov (United States)

    Darwell, C T; Fox, K A; Althoff, D M

    2014-12-01

    There is ample evidence that host shifts in plant-feeding insects have been instrumental in generating the enormous diversity of insects. Changes in host use can cause host-associated differentiation (HAD) among populations that may lead to reproductive isolation and eventual speciation. The importance of geography in facilitating this process remains controversial. We examined the geographic context of HAD in the wide-ranging generalist yucca moth Prodoxus decipiens. Previous work demonstrated HAD among sympatric moth populations feeding on two different Yucca species occurring on the barrier islands of North Carolina, USA. We assessed the genetic structure of P. decipiens across its entire geographic and host range to determine whether HAD is widespread in this generalist herbivore. Population genetic analyses of microsatellite and mtDNA sequence data across the entire range showed genetic structuring with respect to host use and geography. In particular, genetic differentiation was relatively strong between mainland populations and those on the barrier islands of North Carolina. Finer scale analyses, however, among sympatric populations using different host plant species only showed significant clustering based on host use for populations on the barrier islands. Mainland populations did not form population clusters based on host plant use. Reduced genetic diversity in the barrier island populations, especially on the derived host, suggests that founder effects may have been instrumental in facilitating HAD. In general, results suggest that the interplay of local adaptation, geography and demography can determine the tempo of HAD. We argue that future studies should include comprehensive surveys across a wide range of environmental and geographic conditions to elucidate the contribution of various processes to HAD. © 2014 European Society For Evolutionary Biology. Journal of Evolutionary Biology © 2014 European Society For Evolutionary Biology.

  9. A iniciação científica e a publicação na graduação como meios de qualidade na formação de ensino superior: uma entrevista com José Roberto Rus Perez

    Directory of Open Access Journals (Sweden)

    Lucio José Dutra Lord

    2014-11-01

    Full Text Available O tema da qualidade da formação profissional há muito tem dirigido as políticas educacionais e influenciado nas matrizes curriculares dos cursos de graduação no país. Contudo, a questão extrapola este espaço e envolve, cada vez mais, as experiências extraclasses. Deste modo a extensão, pesquisa e publicação universitárias assumem papel relevante para a melhoria do ensino. Nesta entrevista o Professor e Pesquisador Livre Docente José Roberto Rus Perez nos fala da importância da pesquisa e publicação na formação de ensino superior. Seu relato de 30 anos de experiência no Núcleo de Estudos em Políticas Públicas (NEEP/UNICAMP evidencia alguns pontos fundamentais para que o ensino de graduação experiencie a pesquisa e divulgação, através da publicação, como pilares de sustentação do bom ensino. Ele também demonstra a estreita relação entre a formação na graduação e as dificuldades vividas na pós-graduação no país, sobretudo pela carência da pesquisa que é, sempre, tão necessária ao trabalho do profissional no mercado ou no setor público, na licenciatura ou no bacharelado. Cabe ressaltar também que o professor José Roberto Rus Perez é membro do Conselho Consultivo Nacional da Revista Eventos Pedagógicos – REP’s.

  10. Public illumination manual; Manual de iluminacao publica

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1992-12-31

    This work aims to guide in the correct choice and usage of the adequate public illumination equipment. It also aims to help the public authorities in terms of the best economical and technical choice, as well as the adequate maintenance of the equipment in order to obtain the most efficiency and safety with minimum costs 22 figs., 11 tabs.

  11. OPINION PUBLICA, CULTURAS POLITICAS Y DEMOCRACIA

    Directory of Open Access Journals (Sweden)

    Pedro Santana Rodríguez

    1998-01-01

    Full Text Available El autor realiza un acercamiento al deber ser de la democracia desde el abordaje de categorías como opinión pública y consenso, elementos indispensables en la construcción de una cultura política.

  12. Public illumination manual; Manual de iluminacao publica

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1993-12-31

    This work aims to guide in the correct choice and usage of the adequate public illumination equipment. It also aims to help the public authorities in terms of the best economical and technical choice, as well as the adequate maintenance of the equipment in order to obtain the most efficiency and safety with minimum costs 22 figs., 11 tabs.

  13. Por un sistema de interpretación de los procesos de regionalización e integración andina desde el análisis de políticas publicas

    Directory of Open Access Journals (Sweden)

    Catalina Toro Pérez

    2007-01-01

    Full Text Available En Colombia son mas bien recientes, los estudios de investigación sobre el proceso de integración andina y latinoamericana, en tiempos donde, sus relaciones internacionales, oscilan entre una inserción subordinada a los Estados Unidos y su aislamiento frente a los países vecinos, en una solitaria cruzada de por el restablecimiento del mito de la seguridad nacional, la autoridad y el orden en una sociedad que parece, al mismo tiempo, desintegrarse y fragmentarse cada día mas. Sin embargo, mientras el proceso de integración de la Comunidad Andina languidece, un nuevo tipo de regionalización política suramericana, se abre paso, impulsado por movimientos sociales y gobiernos alternativos de Ecuador, Venezuela, Bolivia, Argentina, y Brasil quienes en medio de grandes contradicciones, comienzan a constituir un frente común, contra las políticas de regionalización impuestas por los Estados Unidos, en materia de seguridad, defensa y comercio en el área andina. En un contexto de desintegración andina y de fractura social interna, como abordar la historia de los procesos de integración andina, sus conflictos y sus alternativas de construcción de practicas políticas comunes? Con el fin de aportar a la construcción de un marco de interpretación de los Procesos de Regionalización e Integración Andina, recogemos la contribución reciente de investigadores europeos que desde el campo de la sociología de la acción pública, abordan el análisis de la experiencia comunitaria europea. Luego a partir de diversas aproximaciones a los procesos de Integración andina en particular y latinoamericana en general, arrojamos una primera propuesta de interpretación desde el campo del análisis de las Políticas Publicas.

  14. A publicação de dados governamentais abertos: proposta de revisão da classe sobre Previdência Social do Vocabulário Controlado do Governo Eletrônico

    Directory of Open Access Journals (Sweden)

    Cláudio José Silva Ribeiro

    Full Text Available Este trabalho analisa a classe sobre Previdência Social do Vocabulário Controlado do Governo Eletrônico, investigando a publicação de dados governamentais abertos, realizada pela Empresa de Tecnologia e Informações da Previdência Social. Trata-se de um estudo exploratório, com objetivo de propor a revisão da classe sobre Previdência Social no domínio do Governo Eletrônico brasileiro, a fim de ampliar e corrigir a representação da área. O trabalho utiliza como metodologia: (1 pesquisa bibliográfica, para fundamentação teórica; (2 seleção da classe de assunto sobre Previdência Social do Vocabulário Controlado do Governo Eletrônico, como recorte; (3 análise dos pontos relacionados à categorização, linguagem escolhida (natural ou artificial, cobertura dos termos pertencentes ao escopo da classe de assunto estudado e relações apresentadas entre os termos; (4 propostas para revisão da classe estudada. O estudo aponta, nos resultados, falhas estruturais e inconsistências conceituais localizados no vocabulário. Discute a necessidade de se utilizarem vocabulários consistentes para representação dos dados publicados, a fim de torná-los legíveis por máquina e compartilháveis entre aplicações de software. Afirma que se deve investir em vocabulários já existentes para evitar esforços com a criação de outros instrumentos de representação. Julga necessário que outros órgãos públicos, além da Empresa de Tecnologia e Informações da Previdência Social, interessem-se em analisar e propor alterações e atualizações nas classes cuja temática contemple os dados por eles geridos. Conclui que a utilização do Vocabulário Controlado do Governo Eletrônico pode ir além de um mapa para navegação em páginas eletrônicas do setor público brasileiro, constituindo instrumento dinâmico de organização do conhecimento, podendo ser utilizado para diversos fins, de acordo com os interesses de cada usuário.

  15. Investigações sobre o ensino de Genética e Biologia Molecular no Ensino Médio brasileiro: reflexões sobre as publicações científicas Research on the teaching of Genetics and Molecular Biology in Brazilian High School: reflections about scientific publications

    Directory of Open Access Journals (Sweden)

    José Romário de Melo

    2009-01-01

    Full Text Available Com o objetivo de analisar as publicações relacionadas ao ensino de Genética e Biologia Molecular no Ensino Médio brasileiro, foram consideradas reflexões sobre várias publicações científicas mediante revisão bibliográfica. Foram analisados trabalhos publicados entre 1999 a 2008. A Revista Genética na Escola se destacou quanto à quantidade de artigos publicados. As publicações puderam ser classificadas em diversas categorias, como: análise de livro didático (ALD, histórico (HIS, intrainterdisciplinaridade (IID, metodologia de ensino (MEE, propostas curriculares (PRC e outros (OUT. Embora compatíveis em quantidade, artigos das categorias ALD, HIS e PRC encontram-se publicados em pouquíssima quantidade. O número de artigos publicados nas categorias IID e MEE soma quase 73% das publicações encontradas, em relação às demais (as outras categorias juntas somam aproximadamente 27%. Este estudo possibilitou considerar que ainda é incipiente a pesquisa voltada ao ensino de Genética e Biologia Molecular, com relação ao Ensino Médio na escola básica brasileira.The objective of this work was to analyze the publications related to the teaching of Genetics and Molecular Biology in Brazilian High Schools. We analyzed studies published from 1999 to 2008. The Revista Genética na Escola presents the most published articles. The publications were classified into different categories, such as: textbook analysis (ALD, history (HIS, intra-interdisciplinarity (IID, teaching methodology (MEE, curriculum proposals (PRC and other (OUT. Equivalent numbers of articles in ALD, HIS and PRC categories are published in very low quantity, however the number of articles published in categories IID and MEE total almost 73% of the publications found in the others (all other categories together total about 27%. This study has considered that research dedicated to the teaching of Genetics and Molecular Biology is still in its early stages, related to

  16. The founders of the ININ

    International Nuclear Information System (INIS)

    Bulbulian, S.

    2006-01-01

    The Mexican government sent the constituent law of the National Commission of Nuclear Energy (CNEN) at December 31, 1955. This classification enters in validity the January 1, 1956. However the Commission began to work in the last months 1956. This institution development two main activities: 1. A program of training on techniques with radioisotopes and nuclear instrumentation and 2. The creation of specialized programs and laboratories. Very important persons in the CNEN were the members of the Commission, the Dr. Manuel Sandoval Vallarta, the Dr. Nabor Carrillo Flores and the Atty. Jose Maria Ortiz Tirado, President of this institution. (Author)

  17. G1738R is a BRCA1 founder mutation in Greek breast/ovarian cancer patients: evaluation of its pathogenicity and inferences on its genealogical history.

    Science.gov (United States)

    Anagnostopoulos, Theodore; Pertesi, Maroulio; Konstantopoulou, Irene; Armaou, Sofia; Kamakari, Smaragda; Nasioulas, George; Athanasiou, Athanassios; Dobrovic, Alex; Young, Mary-Anne; Goldgar, David; Fountzilas, George; Yannoukakos, Drakoulis

    2008-07-01

    heterogeneity in the Greek population, the identification of a frequent founder mutation greatly facilitates genetic screening.

  18. Deep genetic divergences among Indo-Pacific populations of the coral reef sponge Leucetta chagosensis (Leucettidae): founder effects, vicariance, or both?

    Science.gov (United States)

    Wörheide, Gert; Epp, Laura S; Macis, Luciana

    2008-01-26

    An increasing number of studies demonstrate that genetic differentiation and speciation in the sea occur over much smaller spatial scales than previously appreciated given the wide distribution range of many morphologically defined coral reef invertebrate species and the presumed dispersal-enhancing qualities of ocean currents. However, knowledge about the processes that lead to population divergence and speciation is often lacking despite being essential for the understanding, conservation, and management of marine biodiversity. Sponges, a highly diverse, ecologically and economically important reef-invertebrate taxon, exhibit spatial trends in the Indo-West Pacific that are not universally reflected in other marine phyla. So far, however, processes generating those unexpected patterns are not understood. We unraveled the phylogeographic structure of the widespread Indo-Pacific coral reef sponge Leucetta chagosensis across its known geographic range using two nuclear markers: the rDNA internal transcribed spacers (ITS 1&2) and a fragment of the 28S gene, as well as the second intron of the ATP synthetase beta subunit-gene (ATPSb-iII). This enabled the detection of several deeply divergent clades congruent over both loci, one containing specimens from the Indian Ocean (Red Sea and Maldives), another one from the Philippines, and two other large and substructured NW Pacific and SW Pacific clades with an area of overlap in the Great Barrier Reef/Coral Sea. Reciprocally monophyletic populations were observed from the Philippines, Red Sea, Maldives, Japan, Samoa, and Polynesia, demonstrating long-standing isolation. Populations along the South Equatorial Current in the south-western Pacific showed isolation-by-distance effects. Overall, the results pointed towards stepping-stone dispersal with some putative long-distance exchange, consistent with expectations from low dispersal capabilities. We argue that both founder and vicariance events during the late Pliocene and

  19. Deep genetic divergences among Indo-Pacific populations of the coral reef sponge Leucetta chagosensis (Leucettidae: Founder effects, vicariance, or both?

    Directory of Open Access Journals (Sweden)

    Epp Laura S

    2008-01-01

    founder and vicariance events during the late Pliocene and Pleistocene were responsible to varying degrees for generating the deep phylogeographic structure. This structure was perpetuated largely as a result of the life history of L. chagosensis, resulting in high levels of regional isolation. Reciprocally monophyletic populations constitute putative sibling (cryptic species, while population para- and polyphyly may indicate incipient speciation processes. The genetic diversity and biodiversity of tropical Indo-Pacific sponges appears to be substantially underestimated since the high level of genetic divergence is not necessarily manifested at the morphological level.

  20. TP53 mutation p.R337H in gastric cancer tissues of a 12-year-old male child - evidence for chimerism involving a common mutant founder haplotype: case report

    International Nuclear Information System (INIS)

    Silva, Edaise M da; W Achatz, Maria Isabel; Martel-Planche, Ghyslaine; Montagnini, André L; Olivier, Magali; Prolla, Patricia A; Hainaut, Pierre; Soares, Fernando A

    2011-01-01

    Gastric adenocarcinoma is rare in children and adolescents, with about 17 cases under age 21 in the world's literature. We report a case of invasive well-differentiated metastatic gastric cancer in a Brazilian 12-year-old boy without documented familial history of cancer. The patient, diagnosed with metastatic disease, died seven months after surgery. DNA from intra-surgical specimens revealed a TP53 mutation at codon 337 (p.R337H) in samples with neoplastic cells (dysplasia, tumor and metastasis) but not in non-transformed cells (incomplete intestinal metaplasia and non-involved celiac lymph node). In all mutation-positive tissues, p.R337H occurred on the same background, a founder allele identified by a specific haplotype previously described in Brazilian Li-Fraumeni syndrome patients. The same mutant haplotype, corresponding to a founder mutation present in 0.3% of the general population in Southern Brazil, was found in the genome of the father. Presence of this inherited haplotype in the tumor as well as in the father's germline, suggests a rare case of microchimerism in this patient, who may have harbored a small number of mutant cells originating in another individual, perhaps a dizygotic twin that died early in gestation. This case represents one of the earliest ages at diagnosis of gastric cancer ever reported. It shows that cancer inheritance can occur in the absence of an obvious germline mutation, calling for caution in assessing early cancers in populations with common founder mutations such as p.R337H in Southern Brazil

  1. A enfermagem de saúde pública no Distrito Federal: a influência do relatório Goldmark (1923 A 1927 La enfermería de salud publica en el Distrito Federal: la influencia del relato goldmark (1923 hasta 1927 The public health nursing in the Distrito Federal: the influence of the goldmark report (1923 to 1927

    Directory of Open Access Journals (Sweden)

    Mary Ann Menezes Freire

    2008-03-01

    Full Text Available Estudo histórico-social, embasado na análise documental. Investiga as influências do Relatório Goldmark na organização da enfermagem de saúde pública, após o processo da Reforma Carlos Chagas, de 1923 a 1927. Objetivos: identificar as circunstâncias em que se deram as primeiras propostas para organizar a enfermagem de saúde pública durante a Reforma Carlos Chagas; analisar as implicações do Relatório Goldmark para a organização do saber e do fazer na enfermagem de saúde pública, na Capital da República, na década de 1920. Podemos citar como uma das implicações do Relatório Goldmark na organização da enfermagem de saúde pública no Distrito Federal a alteração do Standard Curriculum, adotado pela Escola de Enfermagem do Departamento Nacional de Saúde Pública, diante de uma de suas questões centrais, que procurou produzir um equilíbrio no ensino teórico-prático, o que provocou reflexos no saber e no fazer das enfermeiras de saúde pública.Estudio histórico-social basado en el análisis documental. Investiga las influencias del Relato Goldmark en la enfermería de salud publica después del proceso de la Reforma Carlos Chagas, 1923 - 1927. Objetivos: Identificar las condiciones en que ocurrieron las primeras propuestas para organizar la enfermería de salud publica en la Reforma Carlos Chagas; Analizar las implicaciones del Relato Goldmark para la organización de lo saber y de lo hacer en la enfermería de salud publica en la Capital de la Republica en la década de 1920. Podemos citar cómo una de las implicaciones del Relato Goldmark en la organización de la enfermería de salud publica en el Distrito Federal la alteración del "Standart Curriculum", adoptado por la Escuela de Enfermería del Departamento Nacional de Salud Publica, frente una de sus cuestiones centrales que intent�� producir un equilibrio en la enseñanza teórica y practica, lo que causó reflejo en lo saber y el que hacer de las

  2. "Innovation and Organizational Knowledge: A bibliometric mapping of scientific publications until 2009 Inovação e Conhecimento Organizacional: um mapeamento bibliométrico das publicações científicas até 2009

    Directory of Open Access Journals (Sweden)

    Jane Lucia Silva Santos

    2011-09-01

    Full Text Available

    Innovation has been acknowledged as a key factor to boost competitiveness in organizations. This subject has raised the concern of many related fields that have tried to add new meanings and constructs in search of a better explanation for this phenomenon, among them, several scholars have pointed out that organizational knowledge might leverage innovation. In this sense, this article has as objective to map out the pool of international publications where innovation and organizational knowledge are intertwined. Thus, we have used Bibliometrics techniques such as citation analysis to identify the key works in the subject. The results show a growing behavior on the amount of published articles reaching 800 approximately for year 2009. It also shows the predominance of US American and British Institutions in the number of articles as well as in the amount of citations. The contribution of this work lies on shedding more light on the scientific structure of innovation research and points out to the path dependency of the field as well as to the future trends.

    A inovação tem sido reconhecida como um fator crítico para a competitividade das organizações. O tema tem despertado o interesse de várias áreas da ciência, as quais têm agregado novos construtos para tentar explicar como se produz esse fenômeno, entre eles, o conhecimento organizacional como elemento alavancador da inovação. Este trabalho tem por objetivo mapear as publicações internacionais da área de inovação que tratam de conhecimento organizacional. Para isto foram utilizadas técnicas bibliométricas como a análise de citações para identificar os trabalhos relevantes da área. Os resultados apontam um crescimento na quantidade de artigos publicados, chegando aproximadamente a 800 (oitocentos no ano de 2009. Tamb

  3. The Public Health Problems of Nuclear Waste Disposal; L'Elimination des Dechets Radioactifs et la Sante Publique; 041f 0420 041e 0414 ; Problemas que Presenta para la Salud Publica la Evacuacion de Desechos Radiactivos

    Energy Technology Data Exchange (ETDEWEB)

    Dunster, H. J. [United Kingdom Atomic Energy Authority, Health and Safety Branch (United Kingdom)

    1960-07-01

    problemes que pose la fixation d'un taux maximum en ce qui concerne l'evacuation des dechets dans les rivieres, leur enfouissement' dans le sol ou leur immersion dans les eaux profondes de la mer. L'auteur conclut qu'il est possible de demontrer sans difficulte que la plupart des solutions proposees offrent toutes les garanties de securite voulues, mais qu'une enquete et un controle rigoureux sont necessaires lorsque des doses substantiefles de radioactivite peuvent se repandre dans une zone d'habitat humain. (author) [Spanish] Los principios en que se base la solucion de los problemas que presenta para la salud publica la evacuacion de desechos radiactivos son las recomendaciones de la Comision Internacional para la Proteccion Radiologica. Estas recomendaciones no pueden ser aplicadas directamente a Ja evacuacion de desechos debido a que la radiactividad producida no alcanza casi nunca al hombre en forma directa. Asi pues, para establecer las cifras maximas de descarga radiactiva admisibles es preciso conocer no solamente la forma en que el hombre emplea el medio que le rodea sino tambien los distintos procesos que rigen el comportamiento de las materias radiactivas en ese medio precisamente. Como ejemplo de la forma en que el Reino Unido ha tratado estos problemas, el autor de la memoria hace un estudio de la descarga de desechos liquidos de baja actividad en el mar y se refiere brevemente a los problemas similares que plantea el control de las descargas en rios y de la evacuacion en el suelo o en alta mar. Llega a la conclusion de que es posible demostrar sin dificultad el grado de seguridad de la mayoria de las operaciones propuestas para evacuacion de desechos, pero que es necesaria una investigacion y un control meticulosos siempre que haya que evacuar desechos de alto nivel radiactivo en las proximidades de habitaciones humanas. (author) [Russian] Rekomendacii Mezhdunarodnoj komissii po zashhite ot radioaktivnogo obluchenija javljajutsja fundamental'noj osnovoj

  4. Entre a viagem, a escrita e a publicação do relato, um mar de interesses. Argentina, Chile e Nova Zelândia comparados pelo britânico Robert FitzRoy na década de 1830

    Directory of Open Access Journals (Sweden)

    Gabriel Passetti

    2013-06-01

    Full Text Available Este artigo tem por objetivo discutir as relações entre a viagem, a escrita, a publicação de um relato e os interesses pessoais e a conjuntura social e política no momento de sua redação. A discussão recai sobre as escolhas na seleção de temas e formas de descrever locais, a partir de objetivos pessoais, econômicos ou políticos. São analisadas as imagens da América do Sul e da Oceania presentes no livro Narrative of the surveying voyages of HMS Beagle, produzido pelo comandante da Marinha Britânica Robert FitzRoy, entre os anos de 1836 e 1839, no contexto de intensas discussões e projetos para a expansão do império britânico.

  5. Ética na publicação de pesquisas sobre leishmaniose visceral humana em periódicos nacionais Ética en la publicación de investigaciones sobre leishmaniasis visceral humana en periódicos brasileños Ethics in the publication of studies on human visceral leishmaniasis in Brazilian periodicals

    OpenAIRE

    Guilherme Malafaia; Aline Sueli de Lima Rodrigues; André Talvani

    2011-01-01

    OBJETIVO: Analisar os aspectos éticos dos artigos nacionais sobre leishmaniose visceral humana publicados após a Resolução CNS 196/1996 e analisar a política de periódicos brasileiros sobre ética em pesquisa. MÉTODOS: Estudo exploratório de natureza bibliográfica e documental. A seleção das publicações sobre pesquisas envolvendo seres humanos foi realizada na base SciELO Brasil a partir de 1996. Foram analisadas lacunas relacionadas às políticas editoriais dos periódicos médicos a partir de i...

  6. Caracterización de las publicaciones periódicas de la enfermería en Colombia visibles en Internet Caracterização das publicações periódicas da enfermagem na Colómbia visíveis na Internet Characterization of periodical publications on nursing in Colombia, visible in the Internet

    Directory of Open Access Journals (Sweden)

    Lorena Mesa Melgarejo

    2011-07-01

    Full Text Available La publicación de la producción científica es determinante. Lipara el crecimiento disciplinar. Las publicaciones periódicas son el mecanismo más efectivo y válido para divulgar textos de carácter científico. Este estudio buscó caracterizar y describir las publicaciones periódicas de la enfermería colombiana existentes y contextualizar de una manera más aproximada las posibilidades de divulgación de la producción científica de los profesionales de enfermería en Colombia. Método: estudio descriptivo. Se realizaron búsquedas en línea en diferentes bases de datos para hallar las revistas y publicaciones editadas por organizaciones o instituciones de enfermería colombianas que se hacen visibles a través de internet. Resultados: las búsquedas en la red arrojaron un total de 18 publicaciones, de las cuales 12 (67% corresponden a ediciones de facultades y escuelas de enfermería de universidades nacionales públicas y privadas; 3 (17% son boletines informativos; 2 (11% son revistas de organizaciones gremiales y 1 (5% es una publicación editada por un hospital universitario. Discusión: la búsqueda de las revistas que hicieron parte de este estudio fue una travesía compleja; la visibilidad de muchas publicaciones, incluso en buscadores genéricos, es baja, casi nula, situación que estaría de acuerdo con la llamada "cultura del enclaustramiento", lo que implica que, a pesar de la gran cantidad de artículos de interés y de calidad que estas revistas publican, sus aportes teórico-metodológicos a la disciplina de enfermería no tengan mayor impacto.Apublicação da produção científica é determinante para o rescimento disciplinar. As publicações periódicas são os mecanismos mais efetivos e válidos para divulgar textos de natureza científica. Este estudo busca caracterizar e descrever as publicações periódicas da enfermagem colombiana existentes e contextualizar de forma mais apropriada as possibilidades de divulga

  7. 18 June 2012 - DST Global Founder Y. Milner signing the guest book with Head of International Relations F. Pauss; visiting the AD facility in building 193 with AEGIS Collaboration Spokesperson M. Doser and Adviser for the Russian Federation T. Kurtyka. Managing Director I. Osborne also present with Mrs J. Milner and DST Global A. Lebedkina.

    CERN Multimedia

    Maximilien Brice

    2012-01-01

    18 June 2012 - DST Global Founder Y. Milner signing the guest book with Head of International Relations F. Pauss; visiting the AD facility in building 193 with AEGIS Collaboration Spokesperson M. Doser and Adviser for the Russian Federation T. Kurtyka. Managing Director I. Osborne also present with Mrs J. Milner and DST Global A. Lebedkina.

  8. 25 June 2010 - Founder Chairman of the Japanese Science and Technology in Society Forum K. Omi signing the guest book with Head of International Relations F. Pauss, Adviser J. Ellis and Director-General R. Heuer; in the ATLAS visitor centre with Former Collaboration Spokesperson P. Jenni.

    CERN Multimedia

    2010-01-01

    25 June 2010 - Founder Chairman of the Japanese Science and Technology in Society Forum K. Omi signing the guest book with Head of International Relations F. Pauss, Adviser J. Ellis and Director-General R. Heuer; in the ATLAS visitor centre with Former Collaboration Spokesperson P. Jenni.

  9. Análise das publicações sobre capacidades dinâmicas entre 1992 e 2012: discussões sobre a evolução conceitual e as contribuições dos autores de maior notoriedade na área.

    Directory of Open Access Journals (Sweden)

    André Luís Janzkovski Cardoso

    2015-06-01

    Full Text Available Alguns elementos constituintes da abordagem das capacidades dinâmicas aparecem em diversas publicações (Schumpeter, 1942; Penrose, 1959, Nelson & Winter, 1982, Prahalad & Hamel, 1990, mas é a partir de Teece, Pisano e Schuen (1997 que o tema capacidades dinâmicas tem despertado interesse crescente dos estudiosos. A relevância do tema tem levado pesquisadores a considerar capacidades dinâmicas como um novo e robusto paradigma no campo da estratégia, principalmente por propor respostas às lacunas deixadas pela resource-based view (RBV. O arcabouço teórico das capacidades dinâmicas sofreu alterações ao longo do tempo (Barreto, 2010 e apresenta, além de convergências, ramificações entre seus defensores, principalmente no tocante ao embasamento e às fontes teóricas utilizadas em suas diferentes concepções. O conceito de capacidade dinâmica como fonte de vantagem competitiva fez com que estudos sobre esse tema proliferassem ao longo dos últimos anos, contudo essa proliferação ocorre de maneira não homogênea e consensual, o que torna o aprofundamento do tema um desafio ainda maior. Dessa forma, considerando as principais publicações sobre o tema capacidades dinâmicas entre os anos de 1992 e 2012, esta investigação apresenta as contribuições dos principais autores para o desenvolvimento da abordagem das capacidades dinâmicas e discute sua evolução conceitual. Trata-se de um estudo bibliométrico com tratamento dos dados por meio de escala multidimensional e análise de rede. Qualitativamente, a evolução da abordagem é analisada considerando os diferentes conceitos e proposições teórico-empíricas apresentados por autores de maior notoriedade na área, em diversos estudos sobre o tema. Os resultados indicam 1. uma evolução conceitual e de proposições teórico-empíricas; 2. um aumento de citações a autores contribuintes do tema; 3. uma diversidade de fontes de publicação e multidisciplinaridade da

  10. A presença de Francisco Ferrer nas publicações de Maurício Tragtenberg pela Revista Educação e Sociedade (1978 - 2008 = The presence of Francisco Ferrer in Maurício Tragtenberg’s publications by Journal Educação & Sociedade (1978 - 2008.

    Directory of Open Access Journals (Sweden)

    Lenildes Ribeiro Silva

    2011-01-01

    Full Text Available Este trabalho tem por objetivo compreender as relações entre o pensamento de Maurício Tragtenberg e o ideário da "Escola Moderna" de Francisco Ferrer y Guardia, no início do século XX, baseando-se nas publicações de Tragtenberg pela Revista "Educação e Sociedade" (1978-2008. Nessas publicações, intenta-se ressaltar as aproximações do pensamento entre os dois autores na defesa de uma educação voltada aos interesses do operariado, tornando-o uma classe consciente dos processos de dominação da sociedade capitalista e das possibilidades de superação. Na denúncia da monopolização do conhecimento sob interesses particulares, preconceituosos e excludentes, sejam religiosos ou na forma laica do Estado burguês, a educação defendida pelos autores visa conduzir o povo pela via da conscientização, autonomia e autogestão, necessárias a uma verdadeira democracia. Contra o treinamento, a obediência e a manipulação ideológica, os autores convergem na defesa de uma educação no sentido da liberdade, da crítica e da solidariedade.This paper seeks to understand the relationship between the thinking of Maurício Tragtenberg and the ideals of the Modern School of Francisco Ferrer y Guardia in the early 20th century, based on the analysis of Tragtenberg’s publications in the journal “Educação and Sociedade” (1978-2008. In these publications, emphasis is given to the approximations between the thoughts of the two authors in defense of an education focused on the interests of the working class, making it a class conscious of the domination processes of capitalist society as well as the possibilities of overcoming them. By denouncing the monopolization of knowledge by private, prejudiced and exclusionary interests – whether religious or in the secular form of the bourgeois state – the education advocated by the authors seeks to lead people through awareness, autonomy and self-management, all of which are necessary for a

  11. 90-letnij yubilej osnovatelya IAI Petra Grigor'evicha Kulikovskogo %t The founder of "Studies in the history of astronomy" Dr. P. G. Kulikovsky: to his 90th birthday

    Science.gov (United States)

    Eremeeva, A. I.; Laerova, N. B.; Samus', N. N.

    On June 13, 2000, Moscow astronomers congratulated personally P. G. Kulikovsky, the renowned Russian astronomer and teacher of astronomy on his birthday. Born in Kiev in a family with noble Polish and French roots, he graduated from Moscow University in 1938 and worked at Sternberg Astronomical Institute and the Department of Astronomy of Moscow University. His main scientific interests are Galactic astronomy and history of astronomy. Kulikovsky was one of the pioneers of astronomical electrophotometry in the Soviet Union. He was most active in studies of variable stars, investigated connections of their statistical properties with those of the corresponding stars systems. Being a brilliant teacher, he lectured successfully on astronomical subjects in Moscow University. Friends also know him as a talented musician and composer, an author of many piano plays. Kulikovsky has done very much as an organizer of Soviet systematic researches on the history of astronomy. He is the author of many papers on the subject, the founder of the corresponding commission of the USSR Astronomical Council. Kulikovsky was an active member of the IAU, he served as President of the IAU Commission 41 (History of Astronomy) in 1958 - 1964.

  12. Founder effect and estimation of the age of the c.892C>T (p.Arg298Cys) mutation in LMNA associated to Charcot-Marie-Tooth subtype CMT2B1 in families from North Western Africa.

    Science.gov (United States)

    Hamadouche, T; Poitelon, Y; Genin, E; Chaouch, M; Tazir, M; Kassouri, N; Nouioua, S; Chaouch, A; Boccaccio, I; Benhassine, T; De Sandre-Giovannoli, A; Grid, D; Lévy, N; Delague, V

    2008-09-01

    CMT2B1, an axonal subtype (MIM 605588) of the Charcot-Marie-Tooth disease, is an autosomal recessive motor and sensory neuropathy characterized by progressive muscular and sensory loss in the distal extremities with chronic distal weakness. The genetic defect associated with the disease is, to date, a unique homozygous missense mutation, p.Arg298Cys (c.892C>T), in the LMNA gene. So far, this mutation has only been found in affected individuals originating from a restricted region of North Western Africa (northwest of Algeria and east of Morocco), strongly suggesting a founder effect. In order to address this hypothesis, genotyping of both STRs and intragenic SNPs was performed at the LMNA locus, at chromosome 1q21.2-q21.3, in 42 individuals affected with CMT2B1 from 25 Algerian families. Our results indicate that the affected individuals share a common ancestral haplotype in a region of about 1.0 Mb (1 cM) and that the most recent common ancestor would have lived about 800-900 years ago (95% confidence interval: 550 to 1300 years).

  13. Mapping of Chagas disease research: analysis of publications in the period between 1940 and 2009 Mapeamento de pesquisa da doença de Chagas: análise da produção de publicações no período entre 1940 e 2009

    Directory of Open Access Journals (Sweden)

    José Manuel Ramos

    2011-12-01

    Full Text Available INTRODUCTION: Publications are often used as a measure of success in research work. Chagas disease occurs in Central and Southern America. However, during the past years, the disease has been occurring outside Latin America due to migration from endemic zones. This article describes a bibliometric review of the literature on Chagas disease research indexed in PubMed during a 70-year period. METHODS: Medline was used via the PubMed online service of the U.S. National Library of Medicine from 1940 to 2009. The search strategy was: Chagas disease [MeSH] OR Trypanosoma cruzi [MeSH]. RESULTS: A total of 13,989 references were retrieved. The number of publications increased steadily over time from 1,361 (1940-1969 to 5,430 (2000-2009 (coefficient of determination for linear fit, R²=0.910. Eight journals contained 25% of the Chagas disease literature. Of the publications, 64.2% came from endemic countries. Brazil was the predominant country (37%, followed by the United States (17.6% and Argentina (14%. The ranking in production changed when the number of publications was normalized by estimated cases of Chagas disease (Panama and Uruguay, population (Argentina and Uruguay, and gross domestic product (Bolivia and Brazil. CONCLUSIONS: Several Latin American countries, where the prevalence of T. cruzi infection was not very high, were the main producers of the Chagas disease literature, after adjusting for economic and population indexes. The countries with more estimated cases of Chagas disease produced less research on Chagas disease than some developed countries.INTRODUÇÃO: Publicações são frequentemente utilizadas como uma medida de sucesso do trabalho de pesquisa. A doença de Chagas (DCh ocorre na América Central e do Sul. Porém, durante os últimos anos, a doença tem ocorrido fora da América Latina, devido à migração das zonas endêmicas. Este artigo descreve uma análise bibliométrica da literatura sobre as pesquisas da doença de

  14. Analysis of TGM1, ALOX12B, ALOXE3, NIPAL4 and CYP4F22 in autosomal recessive congenital ichthyosis from Galicia (NW Spain): evidence of founder effects.

    Science.gov (United States)

    Rodríguez-Pazos, L; Ginarte, M; Fachal, L; Toribio, J; Carracedo, A; Vega, A

    2011-10-01

      Mutations in six genes have been identified in autosomal recessive congenital ichthyosis (ARCI). To date, few studies have analysed the spectrum of these mutations in specific populations. We have studied the characteristics of patients with ARCI in Galicia (NW Spain). Methods  We recruited patients by contacting all dermatology departments of Galicia and the Spanish patient organization for ichthyosis. TGM1, ALOX12B, ALOXE3, NIPAL4 and CYP4F22 were analysed in the patients and their relatives. We identified 23 patients with ARCI and estimated a prevalence of 1 : 122 000. Twenty of the patients were studied. Seventeen of them were clinically categorized as having lamellar ichthyosis (LI) and three as having congenital ichthyosiform erythroderma (CIE). TGM1 and ALOXE3 mutations were identified in 12/16 (75%) probands whereas no ALOX12B, NIPAL4 and CYP4F22 mutations were found. TGM1 mutations were found in 11/13 (85%) of LI probands. ALOXE3 mutations were identified in a single patient with CIE. Remarkably, mutations p.Arg760X, p.Asp408ValfsX21 and c.984+1G>A of TGM1 were present in six, four and two families, accounting for 41%, 23% and 14% of all TGM1 mutant alleles, respectively. The high percentage of patients with the same TGM1 mutations, together with the high number of homozygous probands (64%), indicates the existence of a strong founder effect in our population. © 2011 The Authors. BJD © 2011 British Association of Dermatologists 2011.

  15. Mathematical modeling of ultradeep sequencing data reveals that acute CD8+ T-lymphocyte responses exert strong selective pressure in simian immunodeficiency virus-infected macaques but still fail to clear founder epitope sequences.

    Science.gov (United States)

    Love, Tanzy M T; Thurston, Sally W; Keefer, Michael C; Dewhurst, Stephen; Lee, Ha Youn

    2010-06-01

    The prominent role of antiviral cytotoxic CD8(+) T-lymphocytes (CD8-TL) in containing the acute viremia of human and simian immunodeficiency viruses (HIV-1 and SIV) has rationalized the development of T-cell-based vaccines. However, the presence of escape mutations in the acute stage of infection has raised a concern that accelerated escape from vaccine-induced CD8-TL responses might undermine vaccine efficacy. We reanalyzed previously published data of 101,822 viral genomes of three CD8-TL epitopes, Nef(103-111)RM9 (RM9), Tat(28-35)SL8 (SL8), and Gag(181-189)CM9 (CM9), sampled by ultradeep pyrosequencing from eight macaques. Multiple epitope variants appeared during the resolution of acute viremia, followed by the predominance of a single mutant epitope. By fitting a mathematical model, we estimated the first acute escape rate as 0.36 day(-1) within escape-prone epitopes, RM9 and SL8, and the chronic escape rate as 0.014 day(-1) within the CM9 epitope. Our estimate of SIV acute escape rates was found to be comparable to very early HIV-1 escape rates. The timing of the first escape was more highly correlated with the timing of the peak CD8-TL response than with the magnitude of the CD8-TL response. The transmitted epitope decayed more than 400 times faster during the acute viral decline stage than predicted by a neutral evolution model. However, the founder epitope persisted as a minor population even at the viral set point; in contrast, the majority of acute escape epitopes were completely cleared. Our results suggest that a reservoir of SIV infection is preferentially formed by virus with the transmitted epitope.

  16. Autosomal recessive deafness 1A (DFNB1A) in Yakut population isolate in Eastern Siberia: extensive accumulation of the splice site mutation IVS1+1G>A in GJB2 gene as a result of founder effect.

    Science.gov (United States)

    Barashkov, Nikolay A; Dzhemileva, Lilya U; Fedorova, Sardana A; Teryutin, Fedor M; Posukh, Olga L; Fedotova, Elvira E; Lobov, Simeon L; Khusnutdinova, Elza K

    2011-09-01

    Hereditary forms of hearing impairment (HI) caused by GJB2 (Cx26) mutations are the frequent sensory disorders registered among newborns in various human populations. In this study, we present data on the molecular, audiological and population features of autosomal recessive deafness 1A (DFNB1A) associated with the donor splicing site IVS1+1G>A mutation of GJB2 gene in Yakut population isolate of the Sakha Republic (Yakutia) located in Eastern Siberia (Russian Federation). The Yakut population exhibits high frequency of some Mendelian disorders, which are rare in other populations worldwide. Mutational analysis of GJB2 gene in 86 unrelated Yakut patients with congenital HI without other clinical features has been performed. In this study, we registered a large cohort of Yakut patients homozygous for the IVS1+1G>A mutation (70 unrelated deaf subjects in total). Detailed audiological analysis of 40 deaf subjects with genotype IVS1+1G>A/IVS1+1G>A revealed significant association of this genotype with mostly symmetrical bilateral severe to profound HI (85% severe-to-profound HI versus 15% mild-to-moderate HI, PA mutation (11.7%) has been found in Yakut population. Reconstruction of 140 haplotypes with IVS1+1G>A mutation demonstrates the common origin of all mutant chromosomes found in Yakuts. The age of mutation was estimated to be approximately 800 years. These findings characterize Eastern Siberia as the region with the most extensive accumulation of the IVS1+1G>A mutation in the world as a result of founder effect.

  17. Criatividade no contexto educacional: análise de publicações periódicas e trabalhos de pós-graduação na área da psicologia Creativity in educational context: analysis of periodical publications and graduate works in the field of psychology

    Directory of Open Access Journals (Sweden)

    Talita Fernanda da Silva

    2012-09-01

    Full Text Available Atualmente, o número de estudos sobre criatividade desenvolvidos no contexto educacional vem-se ampliando, dada a constatação de sua importância tanto para os avanços almejados na educação, quanto para o desenvolvimento do estudante. Nesse sentido, o presente estudo teve como objetivo investigar a produção científica sobre criatividade no contexto educacional dos últimos quinze anos (1995-2009, por meio da análise de publicações periódicas e trabalhos de pós-graduação na área da psicologia. Após consulta a quatro bancos de dados, 82 trabalhos foram analisados em relação ao ano de publicação, à região do país a que pertence o pesquisador, ao nível do trabalho, à temática abordada e ao tipo de pesquisa, de amostra e de instrumentos utilizados. Os resultados mostraram, de maneira geral, um crescimento no número de publicações a partir do ano 2000. A maior parte dos trabalhos vem sendo desenvolvida por pesquisadores das regiões Sudeste e Centro-Oeste; a maioria deles é de cunho empírico, com foco de investigação, em primeiro lugar, na população adulta e, em segundo, na população infantil, envolvendo principalmente professores de ensino fundamental e seus alunos. Dentre os instrumentos que têm sido empregados para avaliação da criatividade no contexto educacional destacam-se o Inventário de barreiras à criatividade pessoal, os Testes de Pensamento Criativo de Torrance e a Checklist de barreiras à promoção da criatividade em sala de aula. A análise demonstrou que, embora se possa notar um aumento no número de trabalhos desenvolvidos no ambiente escolar, lacunas ainda existem em relação a estudos que investiguem essa característica em amostras minoritárias (alunos com deficiência, alunos com altas habilidades, idosos em universidades de terceira idade, espaços não formais de aprendizagem.Currently, the number of studies on creativity implemented in the educational context is increasing, as more

  18. Physicians founders of orthopedic surgery in Serbia

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    Bumbaširević Marko

    2004-01-01

    Full Text Available The beginnings of the development of orthopedic surgery in Serbia have been related to the name of Dr Nikola Krstic and his first radiography of the hand in 1908. The foundation of the Orthopedic Ward, led by Dr Nikola Krstic, within the General State Hospital in Belgrade, in 1919, marks the definition of orthopedics as a separate branch of surgery. In addition to Dr Nikola Krstic, Dr Borivoje Lalovic and Temp. Docent Dr Borivoje Gradojevic, who published the first orthopedics textbook in Serbian in 1934, also worked at the orthopedic ward between the two world wars. The work at the orthopedic ward, which grew into a clinic in 1947, was continued by Prof. Dr Milos Simovic, Prof. Dr Svetislav Stojanovic and Prof, dr Ljubisa Boric. Their successors would have high achievements: Prof. Dr Zivojin Bumbasirevic became the only orthopedist who was a regular member of the Serbian Academy of Sciences and Arts, and Chief of Staff Dr Predrag Klisic and Prof. Dr Branko Radulovic provide impetus for further development of orthopedics by founding Specialist Orthopedics Hospital "Banjica".

  19. Founder lines for improved citrus biotechnology

    Science.gov (United States)

    This article discusses the research needed to develop the RMCE strategy and molecular assays for site-specific recombinases as tools for genome manipulation. Explanation of genetic engineering used to generate transgenic citrus plants to exhibit a novel phenotype, but not to contain the recombinase...

  20. Founders of fish culture - European origins

    Science.gov (United States)

    Fish, F.F.

    1936-01-01

    Just where true fish culture appeared in history depends entirely upon what one considers fish culture to be. If the transportation of fishes from regions of plenty to those of few is to be regarded as fish culture - as it is by some even today - then this story should start in remotest antiquity and deal with an amazing series of failures. However, fish culture to be classed as a science must include far more than mere transportation, it must include a deliberate effort on the part of man to master a technique of fish raising which will yield results far superior to Nature's. Accordingly, the wheel of history must be spun forward to the fifteenth century, A. D., when man first conceived the idea that with care and exactitude, he could improve upon Nature. The fish cultural efforts of the Chinese, the Egyptians, the Greeks, and the Romans may be skipped over in a hurry, for they represented little more than the transportation and rearing of wild fish. With the renaissance of modern civilization in Europe came the birth of scientific fish culture.

  1. Transmitted/founder and chronic subtype C HIV-1 use CD4 and CCR5 receptors with equal efficiency and are not inhibited by blocking the integrin α4β7.

    Directory of Open Access Journals (Sweden)

    Nicholas F Parrish

    Full Text Available Sexual transmission of human immunodeficiency virus type 1 (HIV-1 most often results from productive infection by a single transmitted/founder (T/F virus, indicating a stringent mucosal bottleneck. Understanding the viral traits that overcome this bottleneck could have important implications for HIV-1 vaccine design and other prevention strategies. Most T/F viruses use CCR5 to infect target cells and some encode envelope glycoproteins (Envs that contain fewer potential N-linked glycosylation sites and shorter V1/V2 variable loops than Envs from chronic viruses. Moreover, it has been reported that the gp120 subunits of certain transmitted Envs bind to the gut-homing integrin α4β7, possibly enhancing virus entry and cell-to-cell spread. Here we sought to determine whether subtype C T/F viruses, which are responsible for the majority of new HIV-1 infections worldwide, share biological properties that increase their transmission fitness, including preferential α4β7 engagement. Using single genome amplification, we generated panels of both T/F (n = 20 and chronic (n = 20 Env constructs as well as full-length T/F (n = 6 and chronic (n = 4 infectious molecular clones (IMCs. We found that T/F and chronic control Envs were indistinguishable in the efficiency with which they used CD4 and CCR5. Both groups of Envs also exhibited the same CD4+ T cell subset tropism and showed similar sensitivity to neutralization by CD4 binding site (CD4bs antibodies. Finally, saturating concentrations of anti-α4β7 antibodies failed to inhibit infection and replication of T/F as well as chronic control viruses, although the growth of the tissue culture-adapted strain SF162 was modestly impaired. These results indicate that the population bottleneck associated with mucosal HIV-1 acquisition is not due to the selection of T/F viruses that use α4β7, CD4 or CCR5 more efficiently.

  2. La nueva contraloria social en la gestion publica mexicana

    Directory of Open Access Journals (Sweden)

    Jimenez, E

    2005-07-01

    Full Text Available The aim of this article is to bring abouthe typical mechanisms of control in the administration, its application to public management and the new concept of social regulation. To obtain this, the author briefly mentions the basic concepts of control in a private context,he control mechanisms in the public sector, and the shaping of the social regulation asa means of public participation.

  3. Debate sobre salud publica y despenalizacion del dopaje

    Directory of Open Access Journals (Sweden)

    Miguel Vicente Pedraz

    2013-10-01

    Full Text Available Este artículo pretende alertar de las contradicciones inherentes a la definición del deporte con relación a la salud y la educación. Tomando como referencia el dopaje, intenta elevar al debate público las repercusiones que la industria del rendimiento deportivo tiene en la salud pública. La práctica clandestina del dopaje conduce a muchos deportistas profesionales y aspirantes a la inseguridad sanitaria y a la desorientación ética de los practicantes aficionados y enseñantes del deporte. Por ello, se plantea la necesidad de discutir una eventual despenalización del dopaje en el deporte profesional.

  4. Institucionalizacao da saude publica paulista nos anos 1930-1940

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    Andre Mota

    2013-10-01

    Full Text Available O objetivo do estudo foi interpretar e compreender a institucionalização da saúde pública paulista nos anos 1930-1940, com base na história das especialidades médicas. Foram analisadas novas fontes documentais em diálogo com a literatura existente, levando à identificação de novos indícios relativamente à questão eugênica e à presença de crenças religiosas de médicos como um movimento social. Os médicos, à medida que se especializavam como sanitaristas, propunham um projeto para elevar a raça brasileira, mesclando discursos higienistas com ações sanitárias. São Paulo buscou a primazia nesse projeto, por se acreditar um Estado detentor de uma raça já constituída de “homens historicamente saudáveis”. Crenças religiosas influenciaram o debate e as decisões de época para a ordem sanitária. Historicamente, o discurso sanitário compõe questões técnico-científicas com as político-ideológicas e as culturais, produzindo uma mescla dos diferentes interesses e perspectivas de ordem corporativa da profissão.

  5. Cuidado humanizado como Politica Publica. El caso peruano

    Directory of Open Access Journals (Sweden)

    Fredy Hernán Polo Campos

    2017-04-01

    Full Text Available Resumen Es una experiencia de trasferencia de conocimientos que posibilitó fortalecer el proceso de implementación de una política pública de cuidado humanizado en la Región La Libertad-Perú en el periodo 2007-2014 cuyo objetivo radica en redimensionar las relaciones de poder entre Estado y Sociedad Civil respecto al cuidado de la vida y la libertad, conceptos que dan sentido y fines a una política socio-sanitaria. La experiencia se basó en desarrollar e implementar un modelo de cuidado, iniciando por cuestionar el actual modelo de atención con visas a proponer un modelo orientado a preservar la salud y desarrollo de ciudadanía. Para ello se implementaron procesos de modelamiento de la prestación socio-sanitaria, se modificaron estructuras y se re-inventaron los procesos de gestión sanitaria. Sin duda esta experiencia requiere ser evaluada, fortalecida y mejorar, siendo necesario determinar su efectividad, eficacia y valorar el impacto en la salud y en el desarrollo de la población liberteña para garantizar sostenibilidad e inversión por parte de la clase técnico-política.

  6. Biblioteca Publica en Huntington Beach (EE.UU.

    Directory of Open Access Journals (Sweden)

    Historico, Dion

    1977-07-01

    Full Text Available The first stage, which is the only one completed up to the present time, consists of a more extensive architectural complex conceived for housing different cultural functions besides the library: plastic arts, cinematography, scientific and informative activities, etc. The building is organized in two main floors in a rectangular shape, and in several mezzanines, reading rooms, book deposits, projection areas, music and painting departments and technical administration and maintenance offices, occupying a total of approximately 4,400 m2. The architectural design denotes the intention of integration in the treatment of the inside spaces, by the suppression of separate compartments, organizing the necessary distinction of functions in the reading rooms, by means of differences of floor levels and with the use of adequate decorative elements. In the same manner, the outside walls have been substituted by complete glass surfaces which allow full incorporation of the natural surroundings in the architecture.Constituye la primera fase, única realizada hasta el presente, de un complejo arquitectónico más amplio concebido para albergar distintas funciones culturales además de biblioteca: artes plásticas, cinematografía, actividades científicas e informativas, etc. El edificio se organiza en dos plantas principales, de forma rectangular, y en diversas entreplantas, salas de lectura, depósitos de libros, locales de proyección, departamentos de música y pintura, y oficinas técnicas de administración y mantenimiento, ocupando un total aproximado de 4.400 m2. El planteamiento arquitectónico denota un propósito integrador en el tratamiento de los espacios interiores, por la supresión de las compartimentaciones de fábrica, organizándose la necesaria distinción de ambientes en las salas de lectura, mediante diferencias de nivel del suelo y con el empleo de adecuados elementos decorativos. Del mismo modo, los muros de fachada se han sustituido por paramentos íntegramente acristalados, que permiten una plena incorporación del entorno natural en la arquitectura.

  7. Ciencia, Salud Publica y Educación Medica.

    Directory of Open Access Journals (Sweden)

    José Felix Patiño Restrepo

    1987-12-01

    Full Text Available

    Análisis Critico Del Panorama Actual.

    El conocimiento biomédico ha crecido a una velocidad enorme en el presente siglo y en las últimas décadas ha avanzado mucho más que en el curso de toda su historia.

    También en el presente siglo se han desarrollado en América Latina los conceptos de organización y de economía de la atención médica. en la medida que la opinión pública y los legisladores enfocan su atención hacia los costos del cuidado médico para el ciudadano. la financiación de los hospitales públicos y privados y la obligación del estado de proveer atención para aquellas personas sin acceso a servicios privados. La economía médica se convirtió en un área respetable, a la vez que básica y necesaria desde el punto de vista de la investigación, dentro del contexto general de las actividades médicas y de salud (1. Sin embargo, en otras latitudes ha surgido un peligroso fenómeno, el de la industria de la salud, que provee servicios con ánimo de lucro, dando lugar al denominado complejo médico-industrial que puede llegar a confundir los intereses del público con el de los inversionistas (8. Es así como aspectos relativos a la organización y a la economía de la atención médica son hoy un hecho de la vida diaria, allado de los tradicionales esfuerzos por mantener la excelencia en la calidad de la educación, la investigación y la prestación de servicios.

    Estos fenómenos, de ocurrencia universal, también han sido observados en Colombia y en la América Latina. Pero en la medida que el desarrollo socioeconómico de la atención médica prima como preocupación estatal y aparece prioritario en el panorama político como reflejo de justas aspiraciones ciudadanas, lo cual repercute en el crecimiento de la organización de la seguridad social como servicio público, el sector de la educación médica. representado por las facultades de medicina y los hospitales de enseñanza, públicos y privados, sufre un alarmante deterioro no sólo en su operación y desarrollo. sino aún en su misma filosofía y principios fundamentales (15. Reconocidas autoridades académicas, como A. Neghme de Chile, han denunciado la crisis que afecta a la educación médica y a las universidades latinoamericanas (13, 14. Mucho del progreso alcanzado en el conocimiento biológico y en la aplicación de modernas tecnologías, lo cual significa toda una nueva perspectiva de la medicina y una nueva concepción de la educación médica, aún no ha llegado a nuestras facultades. Lamentablemente parece que buena parte de nuestro profesorado no ha registrado el prodigioso panorama de la nueva biología.

    Lo más sobresaliente de la evolución histórica de la medicina en la segunda mitad del presente siglo. es el vertiginoso avance de la medicina como ciencia. La bioquímica celular, y ahora la biología en los niveles moleculares y submoleculares, han explotado como el nuevo y sobrecogedor campo que gobierna la educación y la investigación médicas. Philip Applewhite de Yale se refiere a “los dioses moleculares” (2, al señalar como la biología molecular significa algo que va más allá de la simple estructura y función orgánica. para determinar aún el mismo comportamiento humano: “nuestro comportamiento es controlado por moléculas, y por nada más … estas moléculas actúan como dioses. por así decir, gobernándonos aún más de lo que podemos imaginar … nuestro comportamiento se debe más a los eventos moleculares que ocurren
    en nuestro interior que a los eventos que tienen lugar a nuestro alrededor”...

  8. Wind power: public policies; Energia eolica: politicas publicas

    Energy Technology Data Exchange (ETDEWEB)

    Ferreira, Henrique Tavares; Faga, Murilo Tadeu Werneck [Universidade de Sao Paulo (USP), SP (Brazil). Inst. de Eletrotecnica e Energia. Programa Interunidades de Pos-graduacao em Energia]. E-mail: henrique@iee.usp.br; murfaga@iee.usp.br

    2006-07-01

    This paper presents the incentive models to the wind power applied in Germany and Denmark, two countries with great participation of wind power in their energetic matrixes, analysing the barriers found to the wind power development.

  9. Public Perception of Bio fuels; Percepcion Publica de los Biocombustibles

    Energy Technology Data Exchange (ETDEWEB)

    Oltra, C.; Priolo, V.

    2011-11-10

    The deployment of bio fuels has generated a significant controversy in the energy, agricultural and environmental fields. Governments and promoters around the world have advocated for developing bio fuels based on their potential contribution to emissions reduction and energy security. But opposition to bio fuels has growth in the last years. Environmental NGO's and other stake holders have called for a review of the environmental and social sustainability of energy crops. This controversy has characterized the public debate around bio fuels. In this context, and given the need to improve public involvement in energy technologies, this article reports an investigation of Spanish citizens' perceptions about bio fuels. The study investigated the perceptions of informed citizens and the reasoning basis underlying beliefs and attitudes. The study finds an initial positive association of bio fuels to a clean and natural fuel that is mitigated by participants' concerns on the practical usage of bio fuels and the social and environmental impacts. Study participants' reactions show the need to differentiate among the diverse groups of publics holding differing views and a different reaction to information on the benefits and costs of bio fuels. (Author) 9 refs.

  10. Energetic evaluation: public schools sector; Avaliacao energetica: setor escolas publicas

    Energy Technology Data Exchange (ETDEWEB)

    Jota, Patricia Romeiro da Silva; Ribeiro, Mariane Correa; Martins, Fernando Henrique Dias; Silva, Valeria R. Borges da [Centro Federal de Educacao Tecnologica de Minas Gerais (CEFET-MG), Belo Horizonte, MG (Brazil). Centro de Pesquisa em Energia Inteligente

    2010-07-01

    Energy consumption evaluation at schools is very important for school management. However, there is a great difference among consumption rates, and a simplified analysis would lead to wrong evaluation. It is not possible to analyze schools that have different number of students or different sizes, unless these variables are applied. This article proposes a methodology in order to develop a sector analysis taking into account operation features. A case study is presented to illustrate this methodology. (author)

  11. Public Perception of Bio fuels; Percepcion Publica de los Biocombustibles

    Energy Technology Data Exchange (ETDEWEB)

    Oltra, C; Priolo, V

    2011-11-10

    The deployment of bio fuels has generated a significant controversy in the energy, agricultural and environmental fields. Governments and promoters around the world have advocated for developing bio fuels based on their potential contribution to emissions reduction and energy security. But opposition to bio fuels has growth in the last years. Environmental NGO's and other stake holders have called for a review of the environmental and social sustainability of energy crops. This controversy has characterized the public debate around bio fuels. In this context, and given the need to improve public involvement in energy technologies, this article reports an investigation of Spanish citizens' perceptions about bio fuels. The study investigated the perceptions of informed citizens and the reasoning basis underlying beliefs and attitudes. The study finds an initial positive association of bio fuels to a clean and natural fuel that is mitigated by participants' concerns on the practical usage of bio fuels and the social and environmental impacts. Study participants' reactions show the need to differentiate among the diverse groups of publics holding differing views and a different reaction to information on the benefits and costs of bio fuels. (Author) 9 refs.

  12. Investigação pedagógica em educação física: análise das publicações em um periódico internacional Pedagogical research in physical education: scope analyses in a international journal

    Directory of Open Access Journals (Sweden)

    Carlos Henrique Ribeiro

    2011-09-01

    Full Text Available O presente trabalho tem como objetivo analisar as publicações de um periódico internacional e traçar o seu perfil editorial. A partir desta análise, traça um quadro comparativo com a produção nacional da Educação Física na sua subárea sociocultural. Para tanto, selecionamos um periódico especializado que fosse considerado de alto conceito pela plataforma WEB QUALIS periódicos, base de dados que tem sido utilizada para avaliar, em última instância, a qualidade dos Cursos de Pós-Graduação Stricto Sensu no Brasil. Nossas análises se pautaram em três grandes categorias, a saber: a a presença constante de pesquisadores advindos das universidades americanas em grande parte dos artigos deste periódico; b a discussão recorrente do papel da educação física como promotora da atividade física em ambientes formais de educação; c a ausência de discussão epistemológica sobre a educação física neste periódico. Como conclusão, discutimos acerca da necessidade de ajustes teóricos e metodológicos por parte da comunidade acadêmica da educação física brasileira, para que seja possível publicar neste periódico internacional.This paper aims to discuss about an editorial scope of pedagogical journal in physical education field. Our intent is compare some of their pedagogical issues with Brazilian ones. We chose the Journal of Teaching in Physical Education because it is well qualified in the Educational Brazilian Governmental web system. We framed our scope in three big issues: a the high concentration of American researchers in the most of papers; b the permanent idea about the Physical Education is the responsible for promote wellness in schools and the related problems; c the absence of epistemic discussions about the role of physical education in the Educational System. At the end, we discuss the necessity of having many theorical and empirical adjustments in the Brazilian Physical Educational papers, so as to we are

  13. Mutación fundadora en una familia argentina con cáncer colorrectal hereditario Detection of a founder mutation in an Argentine family with hereditary non polyposis colorectal cancer

    Directory of Open Access Journals (Sweden)

    Laura Gómez

    2010-02-01

    Full Text Available El cáncer colorrectal hereditario no poliposo (CCHNP se relaciona con mutaciones en los genes reparadores de ADN (MLH1, MSH2 y MSH6. La mayoría de estas alteraciones son familia-específicas y su detección suele requerir la secuenciación completa de los genes relacionados. Se detectó una mutación puntual (2269-2270insT en el último codón del gen MLH1 en familias de un área del norte de Italia (Reggio Emilia y su origen se considera debido a un efecto fundador. En este trabajo presentamos una familia mendocina con CCHNP portadora de la misma mutación, cuyos ancestros eran oriundos de Reggio Emilia. Para la detección de la mutación se diseñó una estrategia basada en PCR y posterior corte enzimático. La mutación fue hallada en tres integrantes de la familia estudiada, dos de los cuales no presentaban sintomatología clínica. Estos pacientes fueron seguidos preventivamente mediante colonoscopias. La metodología utilizada en nuestro laboratorio fue específica y sensible para la detección de una mutación previamente registrada y permitió realizar el diagnóstico genético molecular en el país, evitando el envío de muestras al extranjero. Es de importancia destacar que el diagnóstico genético pre-sintomático de cáncer hereditario, enfocado desde un grupo multidisciplinario de profesionales, permite un mejor seguimiento y apoyo a las familias afectadas.Hereditary non polyposis colorectal cancer (HNPCC has been related to mutations in the DNA mismatch repair genes (MLH1, MSH2 y MSH6. Mutation detection analysis requires the complete sequencing of these genes, given the high frequency of family-specific alterations. A point mutation (2269- 2270insT in the last codon of the MLH1 gene has been detected in families from a northern region of Italy (Reggio Emilia.Given that this alteration was registered only in people from this region, it has been considered a founder mutation. In this work, we present an Argentine HNPCC family

  14. United Kingdom Shadow Secretary of State for Universities and Skills David Willetts MP (centre) in front of the CMS detector with (from left to right) A. Barr, Partner and Founder, Matterhorn Investment Management LLP P. Bate, S. Harper, M. Willetts, T. Virdee, J. Ellis, CMS Spokesperson G. Tonelli, CMS Technical Coordinator A. Ball and (front) Partner, Caravel Capital H. Hsueh and P. Wells. Monday 4th January 2010

    CERN Multimedia

    Maximilien Brice; Point 5

    2010-01-01

    United Kingdom Shadow Secretary of State for Universities and Skills David Willetts MP (centre) in front of the CMS detector with (from left to right) A. Barr, Partner and Founder, Matterhorn Investment Management LLP P. Bate, S. Harper, M. Willetts, T. Virdee, J. Ellis, CMS Spokesperson G. Tonelli, CMS Technical Coordinator A. Ball and (front) Partner, Caravel Capital H. Hsueh and P. Wells. Monday 4th January 2010

  15. Análise das publicações nacionais sobre educação à distância na enfermagem Análisis de las publicaciones nacionales acerca de la educación a la distancia en enfermería Analysis of national publications about distance education in nursing

    Directory of Open Access Journals (Sweden)

    Alessandra Conceição Leite Funchal Camacho

    2009-08-01

    Full Text Available O objetivo é analisar as publicações que trabalham a Educação à Distância na Enfermagem nas principais bases de dados de 2005 a 2009. Estudo de revisão de literatura sistemática realizada nas bases de dados da Biblioteca Virtual da Saúde (Lilacs, Scielo e Bdenf, no período de 19/02/09 à 24/04/09 em 20 referências analisadas. Destacam-se como tônica nas discussões: o desenvolvimento de cursos de capacitação para profissionais de enfermagem bem como em disciplinas nos cursos de graduação via Educação à Distância. Há uma evolução da Educação à Distância na Enfermagem com possibilidades de ensino no ambiente virtual de aprendizagem são inesgotáveis e levam em consideração alguns condicionantes relevantes para interatividade como a disponibilidade de cursos de capacitação e disciplinas nos cursos de graduação.El objetivo es examinar las publicaciones que trabajan la educación a distancia en enfermería en las principales bases de datos de 2005 a 2009. Estudio de revisión de literatura realizada en las bases de datos de la Biblioteca Virtual de Salud (Lilacs, Scielo y Bdenf en el período comprendido entre 19/02/09 al 24/04/09 en 20 referencias. Es tónico en las discusiones: el desarrollo de cursos de capacitación para profisionales de enfermería, cursos en programas de postgrado a través de la educación a distancia. Hay una evolución en la educación a distancia de enfermería con posibilidades de enseñanza en el ambiente virtual de aprendizaje es inagotable y tenen algunas condiciones pertinentes para interactividad como la disponibilidad de cursos de formación y disciplinas de graduación.The objective is to examine the publications working in the Distance Education in nursing in the databases from 2005 to 2009. Study of literature review conducted in the databases of the Virtual Health Library (Lilacs, Scielo and Bdenf in the period from 19/02/09 to 24/04/09 in 20 selected references were reviewed

  16. Muhsin Ertuğrul: Türk Sinemasının Kurucusu mu Yoksa Günah Keçisi mi? / Muhsin Ertuğrul: The Founder or the Scapegoat of Turkish Cinema?

    Directory of Open Access Journals (Sweden)

    Seçkin SEVİM

    2016-10-01

    koymaktır. / Muhsin Ertuğrul (1892-1979 shaped the genetic codes of Turkish cinema with his films he shot in the early decades of the Rebuplic. The literature about Ertuğrul is dominated by Nijat Özön’s critics. Critics that are influenced by Özön’s arguments, held Ertuğrul responsible for the negativities of Turkish cinema. Alim Şerif Onaran’s studies reduced the effect of biased critics about Ertuğrul to some extent. However, the difficulties of struggling in a severe poverty and being a precursor did not prevent Ertuğrul from being considered as a scapegoat. Muhsin Ertuğrul’s theatrical identity supersedes his filmmaker identity as many historians of cinema stated before. Ertuğrul managed to go beyond average only in a few of his films. Even if his cinema heritage can be criticised in many ways, his effort for founding of Turkish cinema cannot be underestimated. Muhsin Ertuğrul has an exceptional place in the history of Turkish cinema because in severe poverty he managed to establish the cinema, which is the most technological branch of arts. Muhsin Ertuğrul’s films can be watched as a reflection of the Kemalist modernisation project. Ertuğrul was a man of culture who struggled to realize the revolutions of the Republic with self-devotion. He was not only the man who made the Turkish women appear in the silver screen but also he became a representative of the ideals of the Rebuplic in field of art during all his life. For this purpose, he was obliged to undertake many missions such as teaching, directing, criticising, acting and translating at the same time. He laid the foundations of theatre and cinema in a country where fighting against epidemic diseases and educating its population at least in a level of primary school were only priorities. Thus, the aim of this study is to put forward the founder role of Muhsin Ertuğrul in Turkish cinema.

  17. Florence Nightingale: Apontamentos sobre a fundadora da Enfermagem Moderna Florence Nightingale: Apuntes sobre la fundadora de la Enfermería Moderna Florence Nightingale: Notes on the founder of Modern Nursing

    Directory of Open Access Journals (Sweden)

    Lúcia Marlene Macário Lopes

    2010-12-01

    amigos y conocidos distinguidos y redactó cerca de 200 obras repartidas entre libros, informes y panfletos, que tuvieron un profundo impacto en la salud y en la reorganización de los servicios de salud. Su obra fue de tal forma revolucionaria y avanzada, que le permitió un alcance mundial, considerado, aún hoy, piedra angular en la profesionalización de la Enfermería.Ahead of her time, although conservative, Florence Nightingale popularized the practice of nursing, allowing the establishment of a new profession for women. A well-educated and cultured woman, she used her knowledge and status to influence health and education policy in her time. She provided nursing care to patients in the battlefields of the Crimea (1854-1856, validating the profession of nursing and setting her on the path to being a status icon and legend. This article is a selected compilation of the literature that aims to honor and make known the path of the person who is considered the founder of modern nursing. Over 90 years of life, Florence Nightingale wrote about 20.000 letters to friends and distinguished acquaintances and wrote about 200 papers, including books, pamphlets and reports, which had a profound impact on health and the reorganization of health services. Her work was revolutionary and advanced in a way that had global outreach, and is still considered nowadays a cornerstone of the professionalization of nursing.

  18. Genetic resources of vegetable crops: a survey in the Brazilian germplasm collections pictured through papers published in the journals of the Brazilian Society for Horticultural Science Recursos genéticos de hortaliças: as atividades nas coleções brasileiras de germoplasma retratadas nas publicações da Associação Brasileira de Horticultura

    Directory of Open Access Journals (Sweden)

    Cláudia P Sudré

    2007-12-01

    nine clusters.A pesquisa com recursos genéticos vegetais é essencial tanto para a conservação da diversidade genética, quanto para o estudo da divergência entre acessos, base para programas de melhoramento. Com objetivo de conhecer o estado-da-arte nesse tema, foram identificados os trabalhos relacionados a recursos genéticos de hortaliças publicados na " Revista de Olericultura" e " Horticultura Brasileira" , de 1961 a 2006. Foram anotadas as espécie(s estudada(s, a instituição de origem do primeiro autor, o ano de publicação, os softwares utilizados, o número de acessos, o número de descritores e o número de técnicas multivariadas aplicadas em cada artigo. Com base nessas caraterísticas, os artigos foram agrupados utilizando análise multivariada. No período pesquisado, 61 artigos trataram, sob algum aspecto, de recursos genéticos. Desses, 91,8% foram publicados a partir de 1990, com concentração de 2001 a 2005 (60,7%, com 57,3% deles utilizando pelo menos uma técnica multivariada, com média de 2,3 e máximo de seis técnicas por artigo. O método de agrupamento de Tocher foi o mais utilizado, relatado em 34% dos artigos. Os artigos cobriram 25 espécies. Dentre elas, Capsicum foi o gênero mais pesquisado, tanto em relação ao número de artigos (sete, quanto em número de acessos estudados (664. As instituições de pesquisa da região Sudeste concentraram o maior número de artigos. Se somadas, UFV, UENF, Embrapa Hortaliças e UNESP Campus de Jaboticabal foram responsáveis por 45% dos trabalhos publicados no tema. Houve um aprimoramento das técnicas estatísticas utilizadas na análise dos dados, sobretudo devido ao desenvolvimento e uso de softwares de fácil compreensão. O programa GENES foi o mais referenciado. Entretanto, quase a metade dos autores não citou o programa estatístico utilizado para a análise dos dados. Os descritores de caracterização morfoagronômica quantitativos e de avaliação foram os mais estudados. A an

  19. Public opinion, public information and public implication in radioactive waste management in the European Union; La opinion publica, informacion publica e implicacion publica en la gestion de residuos radiactivos en la Union Europea

    Energy Technology Data Exchange (ETDEWEB)

    Taylor, D.; Webster, S.

    2004-07-01

    The nuclear industry in European must address the issue of the lack of Public acceptance. In particular, the public are very concerned about radioactive waste. It is clear that there is a need to better inform the public about radioactive waste and to consult them as part of the decision-making process concerning the management of these wastes. Existing and proposed new European legislation not only encourage this provision of information and involvement in the decision-making process, but actually require it. The paper examines Public opinion and European legislation in this area and reports on the latest research on societal issues in radioactive waste management carried out under the Community's Euratom Framework Programme. (Author)

  20. Backing the Founders: The Case for Unalienable Individual Rights

    Directory of Open Access Journals (Sweden)

    Tibor R. Machan

    2010-12-01

    Full Text Available Many may benefit from revisiting the natural rights support for the fully free society even though the case is on record in several books and numerous scholarly pieces. Here I provide a sketch of that support, with a plethora of references for those who would like to explore the full case.The basic point is that adult human beings are moral agents and as such require in their communities respect for–and at times expert protection of–their individual natural rights. This is what gives rise to a polity of very limited government or law. Like referees at a game, whoever maintains and defends the law must stick to that job and not stray into other projects lest the work become corrupted. Such a society will not guarantee good conduct or prosperity but will have the best chance at these.

  1. A founder project: marketing the domestication baseline for forest trees

    Science.gov (United States)

    C. G. Williams; Floyd E. Bridgwater; C. Dana Nelson

    2004-01-01

    One of the most apparent benefits of forest genomics programmes is to provide genotypic information on the original selections of tree improvement programmes worldwide. In many breeding programmes, brances from these selections were grafted onto seedlings and the grafted seedlings composed the first seed orchards for planting programmes. with advanced generation...

  2. Horia Hulubei, father founder of the Institute of Atomic Physics

    International Nuclear Information System (INIS)

    Stratan, G.

    1999-01-01

    Horia Hulubei (b. November 15, 1896, Jassy, d. November 22, 1972, Bucharest) enrolled in 1915 at the University of Jassy, but his studies were interrupted by the WW I. He volunteered first on the Eastern Front, and then in France as a fighter pilot. Wounded and decorated with Legion d'Honneur, he came back to Romania and worked in the field of civil aviation. He graduated in 1926 from the same University with Magna cum Laudae. In 1927, Hulubei went in Paris with a fellowship at the Physical Chemistry Laboratory of Sorbonne and took his Ph. D. in 1933 with Jean Perrin in the field of X-rays spectroscopy, a domain in which he became one of the best specialists of the time. His papers treat a large area of subjects from the multiple Compton effect (predicted and experimentally discovered by him), Raman spectra, the X-ray spectra of gases (obtained for the first time by him in collaboration with Mademoiselle Yvette Cauchois), the identification of elements by X spectroscopy etc. Winner of two prizes of Paris Academy of Sciences, he was elected Corresponding Member of this prestigious French institution. He was also a Directeur de Recherches at the French National Centre of Scientific Research (CNRS). Back in Romania at the beginning of WW II, Hulubei became Professor of Physics, and in 1941, Rector of Bucharest University. After the war, Professor Hulubei dedicated himself to the organization of Romanian research in the field of Physics. The foundation of the Institute of Atomic Physics (IAP) in 1949 in Bucharest was the realization of his dream to build a modern institution of Western type in his own country, tightly connected with the rest of scientific world by international cooperation. Horia Hulubei was practically removed from his directorship of IAP in 1968, following his nomination in a honorary duty, but he remained in a permanent contact with the people formed by him and with the directions of research initiated by him and continued by his followers. The celebration of the Centennial of his birth in 1996 and the commemoration of 25 years from his death in 1997 have shown that the Romanian scientific community has a vivid remembrance of Horia Hulubei, as a great scientist and organizer of Science, ardent patriot and outstanding example for younger generations. (author)

  3. Genomewide association study identifies no major founder variant in ...

    Indian Academy of Sciences (India)

    2013-12-10

    Dec 10, 2013 ... variant in Caucasian moyamoya disease ... 1Department of Health and Environmental Sciences, Kyoto University Graduate ... a low prevalence in European countries (Goto and Yonekawa. 1992; Kuroda and Houkin 2008). We have found that the p.R4810K variant in the ring finger protein 213 (RNF213).

  4. Galileo, Descartes, and Newton - founders of the language of physics

    Czech Academy of Sciences Publication Activity Database

    Kvasz, Ladislav

    2012-01-01

    Roč. 62, č. 6 (2012), s. 519-614 ISSN 0323-0465 Institutional support: RVO:67985955 Keywords : Galilean physics * Cartesian physics * Newtonian Physics * language of physics Subject RIV: AA - Philosophy ; Religion Impact factor: 1.333, year: 2012

  5. Case for nuclear power. Founders Award Lecture, November 18, 1976

    International Nuclear Information System (INIS)

    Benedict, M.

    1976-01-01

    In the three years since the oil embargo, there have been many proposals for greater utilization of our domestic energy resources, but discouragingly slow progress toward adopting them. President Ford's generally sensible energy message of February, 1976 failed to gain the support of a Democratic Congress. Now that the elections are over with the President-Elect and Congress from the same party, it is not too much to hope that a national energy policy will be formulated that will provide for the future energy needs reliably, at an acceptable cost, with low environmental impact and with minimal risk of interruption from overseas. The author proposes to show how increased reliance on nuclear energy can contribute to these goals. Nuclear power plants using light water reactors now have a capacity of 42,000 MW and generate about nine percent of the electricity used in the United States. In some parts of the country 40 percent of the electricity now comes from nuclear plants. By the late 1980s reactors now in operation, under construction, and on order will have a capacity of over 208,000 MW, about 30 percent of the total U.S. capacity expected at that time. If the further projected expansion of nuclear capacity takes place, over 400,000 MW of nuclear power should be in operation by the end of the century, generating around 50 percent of U.S. electricity. The incentives for this increased adoption of nuclear power are its lower cost, the security of its fuel supply, and its lower impact on human health and the environment compared with oil and coal

  6. Gregor Mendel, OSA (1822-1884), founder of scientific genetics.

    Science.gov (United States)

    Dunn, P M

    2003-11-01

    Gregor Mendel, an Augustinian monk and part-time school teacher, undertook a series of brilliant hybridisation experiments with garden peas between 1857 and 1864 in the monastery gardens and, using statistical methods for the first time in biology, established the laws of heredity, thereby establishing the discipline of genetics.

  7. [Charles Robert Darwin: the great founder of scientific evolutionism].

    Science.gov (United States)

    Liang, Qian-Jin; Bin, Jie; Zhang, Gen-Fa

    2009-12-01

    Today, we celebrated 200 years since Charles Darwin, one of the world's most creative and influential thinkers, was born. And there happens to be the 150th anniversary of the publication of his famous book, On the Origin of Species. It is verified that On the Origin of Species is an immortal classic book and is still guiding the study of anagenesis in life science as the development of natural science from then on, and even though most of the ideas in the book are well-known at the present age. In the article, we recall the brilliance and predomination life of Darwin, a great sage with rich scientific achievements, review briefly the novel discoveries and theories after him in the field, and then elucidate the focal points and perspectiveas in near future study of evolution.

  8. [Baron Dominique-Jean Larrey: the founder of urological traumatology].

    Science.gov (United States)

    Hatzinger, M; Ameijenda, C; Lent, V; Sohn, M

    2012-12-01

    Dominique-Jean Larrey (1766-1842) was Surgeon-in-Chief of the Grande Army under Napoleon Bonaparte (1769-1821) and personal physician of the Emperor. Against the opposition of the traditionalists he introduced the "ambulances volantes", the so-called flying ambulances. The aim was the medical treatment of the injured soldiers immediately on the battlefield. This revolutionary treatment led to a benefit not only for the own soldiers, but also for the wounded enemies. His innovation in the field of immediate assistance of wounded persons, together with Larreys' outstanding medical competence, saved thousands of soldiers lives on the battlefield of the Napoleonic wars. His memories concerning the military campaigns, have been even up to the 20th century one of the standard works of modern military surgery. He had as well great interest in urolological injuries of the urinary system and their conservative and operative care. Up to these days, his work shows a surprising actuality and perfect anatomic understanding. In a time without anaesthetics, antibiotics and under primitive circumstances, Larrey and his collegues accomplished surgical feats. Larreys flying ambulances were copied by many different countries. The American Mobile Army Surgical Hospital (M.A.S.H) is clearly based on his thoughts and ideals. In our opinion he is the father of the modern war surgery as well the urological traumatology. Georg Thieme Verlag KG Stuttgart · New York.

  9. Entrepreneurial Founder Effects in the Growth of Regional Clusters

    DEFF Research Database (Denmark)

    Dahl, Michael Slavensky; Pedersen, Christian Ø. R.; Dalum, Bent

    How can the growth of regional clusters be explained? This paper studies in great detail the growth of the wireless communication cluster in Northern Denmark. Unlike the dominant theories, we argue that initial success of the first firms are the main driving force behind the generation of new firms...

  10. [Max Hirsch founder of rheumatology in Germany: banished and murdered].

    Science.gov (United States)

    Keitel, W

    2014-08-01

    The Jewish physician and scientist Dr. Max Hirsch (1875-1941) made a substantial contribution to consolidation of the foundations of his professional discipline, balneology, and in particular developed the social aspects. He recognized the economic significance of diseases of the musculoskeletal system very early on and gathered important ideas from abroad. Together with the department head in the Prussian Ministry of Education and Cultural Affairs, the Privy Councillor Prof. Dr. Eduard Dietrich and later alone, he was editor of various balneological journals. He worked as general secretary of the Deutsche Gesellschaft für Rheumatologie (German Society of Rheumatology) from the beginning of its existence (1927) and created the publication series Veröffentlichungen der Deutschen Gesellschaft für Rheumabekämpfung (Publications of the German Society against Rheumatism) and Rheuma-Jahrbuch (Annual review of rheumatology) in 1929, 1930 and 1931 and organized seven rheumatology congresses up to 1933. After the accession to power of the National Socialists, Max Hirsch and Eduard Dietrich were deposed from office. Hirsch emigrated to Latvia via Switzerland and the Soviet Union with his wife and one son where they were murdered in the course of the Jewish pogrom. The second son escaped with his family to Sweden.

  11. Miguel Angel Matute, founder and promoter of scientific culture

    Directory of Open Access Journals (Sweden)

    Giovanni L. Villalón-García

    2017-06-01

    Full Text Available Miguel Ángel Matute Peña is one of the highest voices of the Universidad de Oriente. His professional performance is characterized to extend several fields of the knowledge where he left a good mark of theorist depth, command of the contents, professional exemplarity and the acting as a teacher that marked the interest of the students to know more about the science that he explained. In this work, the author states the main arguments that demonstrate the role that teacher Matute Peña had in the foundation of the Schools of Physics and Sociology, his leadership in the philosophical studies of Mathematics and in the boarding of the field studies in the communities of Santiago de Cuba, between other aspects.

  12. Microsoft founder opens the Windows of the micro-world

    CERN Multimedia

    2009-01-01

    On Monday 8 June Bill Gates came to CERN for a short visit along with his son Rory. The Bulletin managed to grab a few words with him and discovered how much he appreciates (and supports) fundamental science. After meeting CERN Director-General Rolf Heuer, Gates and his son were given an introduction to CERN by Sergio Bertolucci, Director for Research, and then had a tour of the LHC tunnel, the Control Centre and SM18 with Mike Lamont before heading down to the CMS cavern guided by Jim Virdee, CMS Spokesperson, and Wolfram Zeuner.Millions of kids around the world dream of becoming the next Bill Gates, but Gates’ own son may well dream of becoming a physicist. "One of the reasons we wanted to come here is because Rory, my 10-year-old son, has shown a real interest in physics", explains Gates. "Rory has received some extra home-schooling in science. A lot of what we’ve been discussing has been building up to actually being able to s...

  13. Genomewide association study identifies no major founder variant in ...

    Indian Academy of Sciences (India)

    Young onset (<15 year). 14. –. Adult onset (≤15 year). 24. –. Clinical symptoms. Cerebral infarction. 18. –. TIAb. 6. –. Stroke. 3. –. Headache. 4. –. Hemorrhage. 1. –. Epilepsy. 2. –. Asymptomatic. 1. –. Otherc. 3. –. Clinical status. Bilateral. 35. –. Unilateral. 3. –. aSD, standard deviation; bTIA, transient ischemic attack; cother, ...

  14. A putative founder effect for Parkinson's disease in South African ...

    African Journals Online (AJOL)

    arose in German immigrants from the Volga river region in the 17th century,[1] and in PD ... be most useful to identify individuals who are genetically at risk for developing ... A major advantage of genetic studies is not only that they identify the ...

  15. George de Hevesy (1885 - 1966), founder of radioanalytical chemistry

    International Nuclear Information System (INIS)

    Niese, S.

    2006-01-01

    George de Hevesy has founded Radioanalytical Chemistry and Nuclear Medicine, discovered the element hafnium and first separated stable isotopes. For all these different important achievements he was nominated for the Nobel Prize. On occasion of his discovery of activation analysis 70 years ago his life and work will be illustrated. (author)

  16. Satyendranath Bose: Co-Founder of Quantum Statistics

    Science.gov (United States)

    Blanpied, William A.

    1972-01-01

    Satyendranath Bose was first to prove Planck's Law by using ideal quantum gas. Einstein credited Bose for this first step in the development of quantum statistical mechanics. Bose did not realize the importance of his work, perhaps because of peculiar academic settings in India under British rule. (PS)

  17. Population genetic testing for cancer susceptibility: founder mutations to genomes.

    Science.gov (United States)

    Foulkes, William D; Knoppers, Bartha Maria; Turnbull, Clare

    2016-01-01

    The current standard model for identifying carriers of high-risk mutations in cancer-susceptibility genes (CSGs) generally involves a process that is not amenable to population-based testing: access to genetic tests is typically regulated by health-care providers on the basis of a labour-intensive assessment of an individual's personal and family history of cancer, with face-to-face genetic counselling performed before mutation testing. Several studies have shown that application of these selection criteria results in a substantial proportion of mutation carriers being missed. Population-based genetic testing has been proposed as an alternative approach to determining cancer susceptibility, and aims for a more-comprehensive detection of mutation carriers. Herein, we review the existing data on population-based genetic testing, and consider some of the barriers, pitfalls, and challenges related to the possible expansion of this approach. We consider mechanisms by which population-based genetic testing for cancer susceptibility could be delivered, and suggest how such genetic testing might be integrated into existing and emerging health-care structures. The existing models of genetic testing (including issues relating to informed consent) will very likely require considerable alteration if the potential benefits of population-based genetic testing are to be fully realized.

  18. The founders of the ININ; Los fundadores del ININ

    Energy Technology Data Exchange (ETDEWEB)

    Bulbulian, S [ININ, 52045 Ocoyoacac, Estado de Mexico (Mexico)

    2006-07-01

    The Mexican government sent the constituent law of the National Commission of Nuclear Energy (CNEN) at December 31, 1955. This classification enters in validity the January 1, 1956. However the Commission began to work in the last months 1956. This institution development two main activities: 1. A program of training on techniques with radioisotopes and nuclear instrumentation and 2. The creation of specialized programs and laboratories. Very important persons in the CNEN were the members of the Commission, the Dr. Manuel Sandoval Vallarta, the Dr. Nabor Carrillo Flores and the Atty. Jose Maria Ortiz Tirado, President of this institution. (Author)

  19. The founder of the Friends Foundation--Tessie Soi.

    Science.gov (United States)

    Topurua, Ore

    2013-01-01

    Tessie Soi is well known in Papua New Guinea and beyond for her work with HIV/AIDS (human immunodeficiency virus/acquired immune deficiency syndrome) patients, including through the Friends Foundation, an organization that focuses on helping families affected by HIV and AIDS. This article explores Tessie's early life and childhood, providing insight into some of the values she learned from her parents. Providing details about the Friends Foundation and the Orphan Buddy Systems program, a program Tessie established to support AIDS orphans, the article offers insight into Tessie's beliefs and compassion, simultaneously highlighting the value she places on her family.

  20. Overoptimism among Founders: The Role of Information and Motivation

    NARCIS (Netherlands)

    I. Verheul (Ingrid); M.A. Carree (Martin)

    2008-01-01

    textabstractThis study empirically investigates factors that influence overoptimism across nascent entrepreneurs. We distinguish between two main groups of determinants (information, motivation) and three types of overoptimism (income, psychological burden, leisure time). Findings indicate that

  1. Anemia entre pre-escolares - um problema de saude publica em Belo Horizonte, Brasil

    Directory of Open Access Journals (Sweden)

    Thais de Souza Chaves de Oliveira

    2014-01-01

    Full Text Available O artigo tem por objetivo determinar a prevalência de anemia em crianças matriculadas em creches da regional Centro-Sul de Belo Horizonte (MG, identificando fatores biológicos e socioeconômicos associados. Estudo transversal descritivo realizado em 18 creches. Foram avaliadas 373 crianças com base em amostragem estratificada por instituição participante. A hemoglobina (Hb sérica foi determinada por punção capilar e leitura em β-hemoglobinômetro, adotando-se pontos de corte para anemia de Hb < 11,0g/dL para crianças de seis a 60 meses e Hb < 11,5g/dL para aquelas com idade superior, preconizados pela OMS. O estado nutricional foi definido por aferição do peso e altura e confecção dos índices Peso/Idade (P/I, Estatura/Idade (E/I e IMC/Idade (IMC/I. Entre os participantes 54% eram meninas. A média de idade foi de 38,1 ± 6,2 meses. A prevalência global de anemia foi de 38,3%, sendo superior nas crianças com idade inferior ou igual a 24 meses (56,1%. Encontrou-se associação significativa entre anemia e os fatores menor idade da criança, menor idade materna e baixa renda familiar. O estudo mostrou que anemia em crianças de creches de Belo Horizonte constitui relevante problema de saúde pública, sinalizando a necessidade de se implantar ações específicas para mitigação dos riscos por ele apontados.

  2. Public communication and nuclear energy; La comunicacion publica y la energia nuclear

    Energy Technology Data Exchange (ETDEWEB)

    Cornado, A.

    2006-07-01

    The article tries to explain why on occasion the public's perception of nuclear is more negative than of any other form of electricity generation or issue related to this field, when in reality public opinion has been gradually losing interest in nuclear in recent years. In fact, we could say that as nuclear loses its interest, its presence in the media grows in relation to the environmental aspects of electricity generation, of which nuclear form a part. Of the accusations directed at the nuclear industry, probably the most frequent one concerns the lack of transparency and lack of information on its activities. This article shows how the nuclear sector is probably one that generates more and better information on its own business. However, the lack of social acceptance of this activity, and of the energy business in general, is recognized. To solve this, mention is made of the example of France and Finland, where a well planned communication policy, implemented on a sustained basis over time, and the invitation to society to take part in these issues have favored a substantial improvement of public acceptance of electric generation sources, and specifically the nuclear option. The article ends with some recommendations that could be applied to Spain. (Author)

  3. University of Utrecht 1636-1676: "Res Ecclesia, Res Publica and … Res Pecunia"

    Science.gov (United States)

    van Rinsum, Henk; Koops, Willem

    2016-01-01

    The early history of Utrecht University (founded 1636) reflects an emerging public sphere (Habermas's "bürgerliche öffentlichkeit") of a major town in the Netherlands. This public sphere was a contested field among the different groups establishing and administering the university: university professors, town magistrates and…

  4. LA INEQUIDAD EN EL CAMPO DE LA SALUD PUBLICA EN AMERICA LATINA: UNA CUESTION CRUCIAL

    Directory of Open Access Journals (Sweden)

    Bernardo Kliksberg

    2002-08-01

    Full Text Available América Latina es considerada la región más desigual del planeta. Es el Continente donde, según múltiples fuentes, las polarizaciones son mayores en diversos campos, y el acceso a las oportunidades es marcadamente disímil para los diferentes sectores sociales. ¿Cómo impacta la inequidad latinoamericana el fundamental campo de la salud? ¿Qué problemas determina en esta área decisiva de la vida de las sociedades, y qué obstáculos y trabas pone al avance de los esfuerzos para mejorar la salud?.A pesar de su clara relevancia, este tema ha sido limitadamente puesto a foco. El objetivo de este trabajo es llamar la atención sobre el mismo, y contribuir a estimular este debate tan necesario. Para ello se subraya, en primer término, el papel central de la salud para el desarrollo, se reseñan las amplias brechas que existen, a pesar de ello, a nivel mundial entre países, y a su interior, se encaran ciertos difundidos mitos sobre cómo superar los problemas en salud, se exploran algunos de los principales impactos de la desigualdad de América Latina sobre aspectos básicos del campo de la salud y, finalmente, se sugieren algunas líneas de la gran tarea por realizar para enfrentar el peso de la inequidad sobre la salud pública.

  5. De la res publica al Imperium: Poder y subjetividad en la Roma Imperial

    Directory of Open Access Journals (Sweden)

    Juan Carlos Barrassús Herrero

    2013-05-01

    Full Text Available Este artículo pretende caracterizar la forma de poder imperial romano y las formas de subjetividad que aparecen tras la irrupción de un poder absoluto e irresistible propio del Principado. Trataremos de identificar los elementos de continuidad y discontinuidad que se dan en el ámbito del pensamiento político y de la subjetividad en el período republicano así como en el imperial. Los textos claves para comprender tal paso se encuentran tanto en los escritos de los últimos republicanos ‘convencidos’ así como en una literatura política de la primera época imperial que mira al pasado republicano con nostalgia y veneración, al tiempo que trata de ajustar cuentas con el presente mediante la narración de su corrupción

  6. Constitutional aspects of the economical public policies implantation; Aspectos constitucionais da implantacao de politicas publicas economicas

    Energy Technology Data Exchange (ETDEWEB)

    Andrade, Rogerio Emilio de [Centro de Estudos da Advocacia-Geral da Uniao, Sao Paulo, SP (Brazil)

    2004-10-15

    The article describes a picture, demonstrating the process of production and distribution of indispensable goods to the life in society, which we constructed the notion of capitalism, of which comprehension of cyclic crisis is fundamental to the analysis of the constitutional aspects of implantation of economic public policies. Cyclic crisis whose analysis and consequent comprehension have been object of study of great economy thinkers trying if not to eliminate, at least alleviate their consequences.

  7. Reducao do uso de acucar em escolas publicas: ensaio randomizado por conglomerados

    Directory of Open Access Journals (Sweden)

    Rita Adriana Gomes de Souza

    2013-08-01

    Full Text Available OBJETIVO Analisar a eficácia de ações de educação nutricional com merendeiras na redução da adição de açúcar na alimentação escolar e no próprio consumo. MÉTODOS Ensaio randomizado por conglomerado, controlado, conduzido em 20 escolas municipais na cidade metropolitana de Niterói, RJ, de março a dezembro de 2007. Programa de educação nutricional foi implementado nas escolas de intervenção, junto a merendeiras, usando mensagens, atividades e material educativo que encorajassem a redução da adição de açúcar na alimentação escolar e no consumo. A redução da disponibilidade de açúcar pelas escolas foi analisada por planilhas com dados da utilização dos itens do estoque. O consumo individual das merendeiras foi avaliado pelo uso de questionário de frequência de consumo alimentar. As medidas antropométricas foram realizadas de acordo com técnicas padronizadas e a variação na mudança do peso foi medida ao longo do estudo. RESULTADOS A redução da disponibilidade de açúcar ocorreu mais acentuadamente nas escolas de intervenção quando comparadas às escolas controle (-6,0 kg versus 3,4 kg, sem diferença estatisticamente significante (p = 0,21, embora o poder do estudo tenha sido baixo. Houve redução do consumo de doces e bebidas açucaradas nos dois grupos, mas o consumo de açúcar não apresentou diferenças estatisticamente significativas entre eles. Houve redução do peso e do consumo de energia total nos dois grupos, mas sem diferença estatisticamente significante entre eles e sem modificação dos percentuais de adequação dos macronutrientes em relação ao consumo de energia. CONCLUSÕES Não foi possível provar que a estratégia de redução da disponibilidade e do consumo de açúcar por merendeiras de escolas públicas se mostrou eficaz.

  8. O papel do enfermeiro de saúde publica: projeções no ensino

    Directory of Open Access Journals (Sweden)

    Bertha Cruz Enders

    1995-09-01

    Full Text Available Analisa-se o papel do enfermeiro em saúde pública no contexto do ensino, como ponto de partida para uma avaliação da prática. Objetivou-se 1 Identificar o papel do enfermeiro em saúde pública projetado nos conteúdos programáticos das disciplinas de saúde pública do Curso de Enfermagem na Universidade Federal do Rio Grande do Norte desde sua implantação em 1974 até 1990 e, 2 Avaliar as concepções projetadas no ensino frente a realidade das práticas dos egressos. Conceptualizações da teoria de papeis nortearam o entendimento do termo "papel" e do processo de internalização do conceito. Utilizou-se uma abordagem qualitativa com triangulação na coleta de dados. Dados foram obtidos em duas fontes: nos conteúdos programáticos do Curso e nas opiniões dos enfermeiros egressos do Curso. Técnicas de análise documental foram aplicadas a 70 programas de disciplinas de Saúde Pública e uma amostra aleatória estratificada de 60 enfermeiros foi entrevistada utilizando um questionário específico. Os dados foram analisados à luz da teoria de papeis para a identificação do conceito. Em seguida, se analisou o conceito com base nas políticas de saúde vigentes da época em estudo. Os resultados demonstram que o papel do enfermeiro em saúde pública projetado nos conteúdos focaliza funções múltiplas, assistenciais educativas e administrativas dentro de uma visão preventiva. O objetivo da enfermagem em saúde pública tem sido a prevenção, dentro de uma prática de assistência primária e mais recentemente, dentro de uma perspectiva de mudança e de transformação das questões sociais e das políticas de saúde. Focaliza o enfermeiro planejador, competente nas técnicas epidemiológicas. A percepção dos egressos é também preventiva e focaliza o papel educador e conscientizador do enfermeiro, embora pouco avanço se observa com relação às questões sociais da população. Existe uma incompatibilidade entre os conceitos expressos no curso e os exigidos na prática profissional, refletindo insatisfação dos egressos com a formação recebida no Curso que ressaltam insegurança técnica na prática. Conclui-se que o conceito da prática de enfermagem em saúde pública tem atendido as demandas das políticas de saúde vigentes, porém não as demandas da prática do enfermeiro. Tal divergência entre o ensino e a prática de enfermagem em saúde pública aponta a necessidade de uma revisão curricular no que tange o objeto de trabalho da enfermagem em saúde pública.

  9. das publicações em periódicos nacionais

    Directory of Open Access Journals (Sweden)

    Marléa Chagas Moreira

    2006-01-01

    Full Text Available Estudio de clasificación sobre la producción del conocimiento en la enfermería en oncología. Los objetivos son: identificar las publicaciones en la enfermería en oncología en el período entre 1994 y 2004 y, analizar en las publicaciones, los aspectos epistemológicos señalados en las tematicas focalizadas y en el encuadramiento teorico-metodológico adoptado en los estudios. El referencial teorico-metodológico conjuntamente a una metodología epistemológica para la investigación en la enfermería. Fueram utilizados como fuentes de datos tres periódicos: la Revista Brasileña de Enfermería, la Revista Latinoamericana de Enfermería y la Revista Brasileña de Cancerología . De acuerdo con los resultados, las autoras consideran que el conocimiento producido en el área de la enfermería oncológica éstos son consistentes con la complejidad y las tentativas de explicación sobre el arte de cuidar de los clientes y con los esfuerzos de ampliar los criterios y los patrones asistenciales.

  10. Publicações póstumas de Henri Fayol: revisitando sua teoria administrativa.

    Directory of Open Access Journals (Sweden)

    Edson Miranda de Souza

    2011-02-01

    Full Text Available O engenheiro francês Henri Fayol (1841-1925 é usualmente apresentado aos estudantes de Administração como o Pai da Escola Clássica de Administração, o que demonstra uma representação limitada da amplitude de sua contribuição para a evolução do pensamento administrativo. Além disso, é frequentemente associado ao seu contemporâneo, o teórico norte-americano Frederick Taylor, sendo aos dois atribuída a defesa de um modelo autoritário de administração. Entretanto, recentemente, pesquisadores descobriram, através do exame de documentos raros e inéditos, um desconhecido retrato desse pioneiro. Este trabalho resulta de uma investigação que buscou levantar fontes de informação bibliográfica disponíveis, publicadas ou não, incluindo resultados de trabalhos de pesquisadores da França, dos Estados Unidos, do Canadá, da Austrália e do Japão. Esses pesquisadores compõem um reduzido grupo de estudiosos, aqui denominados “novos fayolistas” porque retomam, depois de anos de quase amnésia no meio acadêmico, o interesse pelas contribuições de Henri Fayol. Tais estudos revelam conceitos desenvolvidos por Fayol que antecipam aspectos de teorias e práticas da Administração que, somente mais tarde, seriam desenvolvidas, como a Escola de Relações Humanas, a Teoria Contingencial e o Planejamento Estratégico. Ao apresentar as recentes pesquisas sobre o homem e o teórico Henri Fayol, este estudo permite, aos docentes e estudantes de língua portuguesa, acesso a escritos e palestras de sua autoria que, até então, permaneciam desconhecidos.

  11. Forgery from the Point of View of Criminal Illicitness, Putative Deeds and Disregarding Fides Publica

    Directory of Open Access Journals (Sweden)

    Monica Pocora

    2013-08-01

    Full Text Available Forgery by its nature, always harms the trust that people are forced to have and need to grant one another in the relations among themselves or which they should show for the things usually considered as the expression and evidence of truth. While for the offenses committed by violation of trust, this is the rule applied intuitu personae, taking into account the personal condition of the person to whom trust is granted, in forgery crimes trust is given in rem, meaning to the thing per se perceived as being the expression of truth. Thus, we are not in front of a violation of trust given to certain people, but in front of the trust granted to the thing which is assumed legally the characteristic of expressing the truth, but truth which has been altered. This paper aims to be an interdisciplinary approach, starting from the criminological meaning rendered to public trust and up to its legal effects produced, set into criminal or extra-criminal content, an approach derived from applying the method of observation.

  12. Opinión publica, culturas políticas y democracia

    Directory of Open Access Journals (Sweden)

    Pedro Santana Rodríguez

    1998-10-01

    Full Text Available El autor realiza un acercamiento al deber ser de la democracia desde el abordaje de categorías como opinión pública y consenso, elementos indispensables en la construcción de una cultura política.

  13. Publicações póstumas de Henri Fayol: revisitando sua teoria administrativa

    OpenAIRE

    Souza, Edson Miranda De; Aguiar, Afrânio Carvalho

    2011-01-01

    O engenheiro francês Henri Fayol (1841-1925) é usualmente apresentado aos estudantes de Administração como o Pai da Escola Clássica de Administração, o que demonstra uma representação limitada da amplitude de sua contribuição para a evolução do pensamento administrativo. Além disso, é frequentemente associado ao seu contemporâneo, o teórico norte-americano Frederick Taylor, sendo aos dois atribuída a defesa de um modelo autoritário de administração. Entretanto, recentemente, pesquisadores des...

  14. Problemas de citação em publicações de Psicologia

    Directory of Open Access Journals (Sweden)

    Almir Del Prette

    2010-11-01

    Full Text Available Considering the need to prepare researchers to communicate scientific knowledge in Psychology, this text reports and categorizes some common problems regarding citations found in a restrict pool of dissertations, thesis, published papers and books published between 2004 and 2007. Two researchers identified potential problems with complete agreement on the definition and the examples for each one of the eight categories produced by the analysis labeled as: unnecessary, showcase, mistaken figure-ground, out-of-time, sprayed, superimposed and masked. The current report focuses on the need for more caution with the use of citations in scientific texts as a way to improve the identification and appreciation of the studies mentioned and to avoid inaccuracy regarding the original ideas of the  quoted authors.   Keywords: scientific methodology; scientific writings; quotations; quotation mistakes.

  15. Complexo agroindustrial, grupos de interesses e politicas publicas : o caso do trigo no Brasil

    OpenAIRE

    Alvaro Ramalho Junior

    1994-01-01

    Resumo:Esta tese procura demonstrar que apesar de ter sido definida por um instrumento de força, em plena vigência de um regime autoritário, a política tritícola desencadeada pela promulgação do Decreto-Lei 210, de 1967, não pode ser caracterizada como uma imposição unilateral do Estado, mas, sim, como resultado de um intercâmbio que pretendeu conciliar interesses públicos e de grupos privados. Evidenciou-se ainda que a política tritícola definida por aquele decreto-lei resultou de um process...

  16. EL IMPACTO DEL ICE EN LAS FINANZAS PUBLICAS Y EN LA ECONOMÍA NACIONAL

    Directory of Open Access Journals (Sweden)

    Rebeca Howell Blanco

    2005-12-01

    Full Text Available El presente trabajo es el resultado de un estudio realizado en la Dirección de Planificación Estratégica Institucional del ICE, como parte de un trabajo de práctica dirigida para optar por el grado de licenciatura en economía en la Universidad Nacional. El propósito del estudio es informar en términos cuantitativos acerca del aporte neto del ICE a las finanzas públicas y a la economía nacional para contribuir en el debate en torno al tema del futuro del ICE en Costa Rica.

  17. Publicações póstumas de Henri Fayol: revisitando sua teoria administrativa.

    OpenAIRE

    Edson Miranda de Souza; Afrânio Carvalho Aguiar

    2011-01-01

    O engenheiro francês Henri Fayol (1841-1925) é usualmente apresentado aos estudantes de Administração como o Pai da Escola Clássica de Administração, o que demonstra uma representação limitada da amplitude de sua contribuição para a evolução do pensamento administrativo. Além disso, é frequentemente associado ao seu contemporâneo, o teórico norte-americano Frederick Taylor, sendo aos dois atribuída a defesa de um modelo autoritário de administração. Entretanto, recentemente, pesquisadores des...

  18. Ciencia e gestão na universidade publica : das interfaces epistemologicas a praxis possivel

    OpenAIRE

    Fernando Antonio Hello

    2009-01-01

    Resumo: O presente trabalho aborda uma universidade pública, do ponto de vista administrativo, em seus aspectos de perenidade enquanto instituição e de sustentabilidade enquanto organização, articulando a gestão administrativa, no geral, e a gestão de pessoas, no particular, na Universidade Estadual de Campinas - UNICAMP. Nosso objetivo é estudar, através de uma abordagem de cunho estruturalista, como se articulam o ethos universitário naquilo que tem de característico e predominante em ações...

  19. Nuevos objetivos de la educacion superior: idealidad y realidad de la universidad publica en Mexico

    Directory of Open Access Journals (Sweden)

    Jimenez Gomez, E.

    2004-01-01

    Full Text Available Este ensayo plantea en términos generales que la educación como compromiso fundamental del estado no ha estado a la altura del reto del tercer milenio. Se pone énfasis en la educación superior pública sobre dos aspectos fundamentales: el meramente financiero al no contar con los recursos suficientes para satisfacer la demanda nacional; y el más importante desde el punto de vista del autor y que se refiere a la conceptualización de la propia universidad, su función social tradicional y los nuevos objetivos que el autor propone para un auténtico Sistema Nacional de Educación que contribuya a resolver los problemas más urgentes de nuestra sociedad.

  20. The public opinion and ATC; La opinion publica y el ATC

    Energy Technology Data Exchange (ETDEWEB)

    Ballera, J.

    2010-07-01

    The role of the media is essential to adopt a final decision in relation to the location of a Centralized Temporary Storage (ATC)in Spain. to the deliberative process is public, open and transparent, as included in Royal Decree that created the Inter ministerial Commission responsible for overseeing the procedure, it is necessary for that citizens has information, clear and unequivocal. indicators such as the special edition of the Eurobarometer survey published in June 2008 showed that it is moving towards a truly informed public opinion in these matters. (Author)

  1. Entre o mito e apropaganda politica : Janio Quadros e sua imagem publica (1959-1961)

    OpenAIRE

    Jefferson Jose Queler

    2008-01-01

    Resumo: Pretendo, neste texto, analisar a construção da imagem pública de Jânio Quadros entre 1959 e 1961. Durante este período, ele disputou as eleições presidenciais brasileiras e governou o país até sua renúncia à Presidência. De acordo com a historiografia ? numa posição similar quando comparada a posições comumente veiculadas pela memória coletiva -, o personalismo dele poderia ser apontado como o principal fator para explicar sua força política, e a propaganda política ajudaria a constr...

  2. Nuclear public information activities in Chile; Programa de educacion publica de la energia nuclear en Chile

    Energy Technology Data Exchange (ETDEWEB)

    Munoz Quintana, R [Comision Chilena de Energia Nuclear, Santiago (Chile)

    1995-10-01

    Nuclear plans and developing programs in developing and developed countries are facing-in a higher or lower degree- opposition from public opinion. The objectives and contents of the public education program on nuclear energy in Chile are dealt with in this paper.

  3. Evaluacion ciudadana del desempeño de la Gestion Publica Municipal

    Directory of Open Access Journals (Sweden)

    Graciela Delgadillo

    2010-01-01

    Full Text Available This article presents the result of a study whit the objective to identify and measure the impact of the factors that the citizens uses to evaluate the public management performance in a specific territorial and temporary space in the sphere of action of local government. With a sample of 250 Mexican citizens that normally live in Guadalupe, Nuevo Leon, Mexico conformed by 126 (50,4% women of between 23 and 73 years with a mean of 43 years old and 124 (49,6% men of between 18 and 71 years with a mean of 38 years old, the most important findings allowed to identify the factors that mainly influence the evaluation that the citizen does about the local government performance are: the effectiveness of the public services, the honesty of the public workers and the accountability just only linked to the access of public information. The study also offers evidence that confirm variation does not exist between men and women in their way of local government performance evaluation.

  4. "Mõisaromantika" jätkub Tõstamaa mõisakoolis / Silja Joon

    Index Scriptorium Estoniae

    Joon, Silja, 1966-

    2006-01-01

    Kontsertidest sarja "Mõisaromantika" raames: "Võrratu klavessiin" 28. okt. Tõstamaa mõisakoolis (barokkansambel Corelli Consort), nov. lõpul "Jõulud mõisas" Taagepera lossis ja Vihterpalu mõisas (jazztrio Tafenau-Vind-Padilla), esinejatest

  5. Huvilised sukeldusid nahkhiirte maailma / Vello Jaska

    Index Scriptorium Estoniae

    Jaska, Vello, 1949-

    2012-01-01

    Taageperas Kivimäe turismitalus toimunud looduslaagris rääkis nahkhiirtest Tallinna Ülikooli lektor, MTÜ Suurkõrv spetsialist Triinu Tõrv, looduslaagri korraldas Ala põhikooli õpetaja Evelyn Tamm

  6. Anneli Remme soovitab : Kammerdžässi kava "Jõulud mõisas" / Siim Nestor

    Index Scriptorium Estoniae

    Nestor, Siim, 1974-

    2006-01-01

    Eesti-Tšiili trio Raivo Tafenau - Meelis Vind - Ricardo Padilla kontsertidest sarja "Mõisaromantika" raames 25. nov. Taagepera lossis Valgamaal, 26. nov. Tõstamaa mõisas Pärnumaal ja 16. dets. Vihterpalu mõisas Harjumaal

  7. Zdess dõshite, zdess ne dõshite / Lidia Iljina

    Index Scriptorium Estoniae

    Iljina, Lidia

    2006-01-01

    Tuntud politoloog Rein Taagepera tegi ettepaneku, et presidendikandidaadid läbiksid kohustuslikus korras arstliku läbivaatluse. Arvamused Toivo Tootsenilt, Liina Tõnissonilt ja psühholoog Jüri Ennetilt

  8. Kümnendikku riigikogust seovad peresidemed / Rein Sikk

    Index Scriptorium Estoniae

    Sikk, Rein, 1961-

    2007-01-01

    Vastvalitud riigikogus seovad kahtteist liiget perekondlikud sidemed. Vt. samas: Kas onupojapoliitika või juhus? Kommenteerivad: politoloog Rein Toomla, TÜ professor Marju Lauristin, TLÜ professor Rein Ruutsoo, emeriitprofessor Rein Taagepera

  9. Juugendloss Eestimaa ääre peal / Helju Koger

    Index Scriptorium Estoniae

    Koger, Helju, 1943-

    2003-01-01

    Aastaid raviasutusena tegutsenud Taagepera loss avas mais 2003 oma uksed hotelli ja konverentsikeskusena. 1912. a. valminud jugendhäärberi projekteeris Otto Wildau. Hoone omanikest, arhitektuurist. Hotelli sisekujunduse tegi Kadri Tarbe. Lossis on avatud harrastusfotograaf Peeter Sepa näitus "Eestimaa tagumises sopis Taageperas", keraamik Marget Tafeli näitus "Dora aarded", Leonhard Lapini ja Ülevi Eljandi näitus "Sõbrad SOUP 69-st". 16 ill

  10. [ELIE METCHNIKOFF--THE FOUNDER OF LONGEVITY SCIENCE AND A FOUNDER OF MODERN MEDICINE: IN HONOR OF THE 170TH ANNIVERSARY].

    Science.gov (United States)

    Stambler, I S

    2015-01-01

    The years 2015-2016 mark a double anniversary--the 170th anniversary of birth and the 100th anni- versary of death--of one of the greatest Russian scientists, a person that may be considered a founding figure of modern immunology, aging and longevity science--Elie Metchnikoff (May 15, 1845-July 15, 1916). At this time of the rapid aging of the world population and the rapid development of technologies that may ameliorate degenerative aging processes, Metchnikoff's pioneering contribution to the search for anti-aging and healthspan-extending means needs to be recalled and honored.

  11. IDENTIFIKASI IKAN CUPANG (Betta imbelis TRANSGENIK FOUNDER MEMBAWA GEN PENYANDI HORMON PERTUMBUHAN; Identification of Transgenic Founder Betta Fish (Betta imbelis Carry Growth Hormone Gene.

    Directory of Open Access Journals (Sweden)

    Eni Kusrini

    2017-01-01

    Full Text Available Penelitian dilakukan untuk mengidentifikasi keberhasilan introduksi gen penyandi hormon pertumbuhan (Growth Hormone, GH pada induk F-0 ikan Betta imbellis. Ikan transgenik F-0 dibuat dengan menggunakan metode transfeksi. Identifikasi dilakukan menggunakan metode RT-PCR. RNA total diekstraksi dari embrio pooled sample hasil persilangan induk transgenik dan non-transgenik. Berdasarkan analisis ekspresi gen pada embrio juga menunjukkan adanya aktivitas ekspresi gen GH pada semua perlakuan dibandingkan dengan kontrol (embrio hasil persilangan non-transgenik x non-transgenik. Jumlah individu induk F-0 yang membawa gen GH eksogen berdasarkan analisis PCR dengan DNA template dari sirip ekor adalah sebanyak 16%. Individu positif membawa gen GH eksogen tersebut dibesarkan lebih lanjut untuk memproduksi Betta imbellis transgenik F-1. Kandidat ikan transgenik jantan F-0 dikawinkan dengan ikan non-transgenik betina, sedangkan transgenik F-0 betina dikawinkan dengan non-transgenik jantan. Sebanyak 30-50 butir embrio hasil pemijahan F-0 digabung, kemudian DNA genom diekstrak. Sebagian embrio digunakan untuk ekstraksi RNA total untuk analisis ekspresi mRNA GH eksogen. Hasil analisis PCR menunjukkan bahwa semua sampel embrio dari induk transgenik F-0 dapat terdeteksi gen GH eksogen, sedangkan untuk kontrol (non-transgenik tidak terdeteksi. Ekspresi mRNA juga terdeteksi pada embrio F-1. Dengan demikian, metode transfeksi embrio Betta imbellis efektif digunakan untuk menghasilkan ikan transgenik, dan sangat berpotensi menghasilkan individu F-1 Betta imbellis dengan pertumbuhan lebih cepat. The study was conducted to identify the successful introduction of the growth hormone gene (Growth Hormone, GH on the F-0 Betta imbellis broodstock. The F-0 transgenic fish was made through transfection methods. Identification was done using RT-PCR method. Total RNA was extracted from pooled embryos sample. Based on the analysis of gene expression in embryos also showed activity GH gene expression in all treatments compared to the control (non-transgenic x non-transgenic. The number of individuals F-0 which carried exogenous GH gene by PCR analysis of the DNA template of the tail fin was as much as 16%. Positive individuals carried the exogenous GH gene raised further to produce transgenic F-1 B. imbellis. Candidate of transgenic F-0 males fish were mated with non-transgenic female fish, whereas the transgenic F-0 females were mated with non-transgenic males. The 30-50 embryos obtained were combined, then their genomic DNA were extracted. Some of the embryos was used for the extraction of total RNA for analysis of mRNA expression of GH exogenous. The PCR analysis showed that all samples of embryos from the transgenic F-0 broodstock could be detected, whereas for the control (non-transgenic was not detected. mRNA expression was also detected in embryos of F-1. The average weight of the F-0 broodstocks were 1.55 g and a total length was 12.97 cm. Thus, the transfection methods through betta embryos peaceful effectively generated transgenic fish, and potentially produced fast growth of individuals F-1 Betta imbellis.

  12. Improving of health and safety contribution of OECD/NEA Radiation Protection Committee and Public Health; Mejora de la salud publica y la seguridad. contribuciones de la OECD/NEA, comite de Proteccion Radiologia y Salud Publica

    Energy Technology Data Exchange (ETDEWEB)

    Lazo, T.

    2004-07-01

    The OECD Nuclear energy Agency, has, since 1957, been addressing issues in radiological protection through its Committee on Radiation Protection and Public Health (CRPPH). The Committee is made up of regulators and radiation protection experts, with the broad mission to provide timely identification of new and emerging issues, to analyse their possible implications and to recommend or take action to address these issues to further enhance radiation protection regulation and implementation. The regulatory and operational consensus developed by the CRPPH on these emerging issues supports policy and regulation development in Member countries, and disseminates good practice. To best serve the needs of its Member countries, the CRPPH has been focusing its work in recent years on a few key topic areas. These induce the evolution of the system of radiological protection, the advancement of preparedness for nuclear emergency accidents, and the improvement of occupational exposure management at nuclear power plants. With the International Commission on Radiological Protection about to issue new recommendations, due out in 2005, the CRPPH will take advantage of the radiological protection community's recent focus on emerging policy and strategic issues to develop a new CRPPH Collective Opinion. This document, to be published in 2005, will serve the Committee as a guide for its programme of work for the coming 5 to 10 years. (Author) 13 refs.

  13. Public Perception of Urban Air Pollution: An Exploratory Study; Percepcion Publica de la Contaminacion Atmosferica Urbana: Un Analisis Exploratorio

    Energy Technology Data Exchange (ETDEWEB)

    Sola, R.; Oltra, C.; Goncalves, L.

    2014-02-01

    This report presents the results of a qualitative study using focus groups aimed at understanding the beliefs and attitudes of the population towards air pollution, its levels, causes, health impacts and possible mitigation and protection actions. The study sample consisted of members of the general population, between 18 and 65 years living in Barcelona. The analysis of the group discussion indicates that there is little awareness among participants about air pollution risks. The causes of air pollution are relatively known but there is little knowledge about pollution levels and types of pollutants. We found a low level of perceived personal risk associated to air pollution that coexists with a general awareness of the health impacts of air pollution, a low level of concern about the problem and a low level of personal involvement in mitigation and self protection measures. Participants reported no use of existing information services about air pollution. (Author)

  14. Referências de periódicos médicos brasileiros em publicações nacionais

    Directory of Open Access Journals (Sweden)

    Renan Kleber Costa Teixeira

    2013-12-01

    Full Text Available OBJETIVO: Avaliar se há preferência pela citação de periódicos internacionais em detrimento dos nacionais em 10 periódicos nacionais de medicina em dois períodos de tempo distintos. MÉTODOS: Foram avaliadas todas as referências dos artigos publicados nos periódicos Arquivos Brasileiros de Oftalmologia, Revista Brasileira de Cirurgia Cardiovascular, Revista da Associação Médica Brasileira, São Paulo Medical Journal, Arquivos Brasileiros de Endocrinologia e Metabologia, Clinics, Jornal Brasileiro de Pneumologia, Revista da Sociedade Brasileira de Medicina Tropical, Revista Brasileira de Psiquiatria e Acta Ortopédica Brasileira nos anos de 2011 e 2007, verificando a quantidade de artigos provenientes de revistas nacionais e internacionais. RESULTADOS: Foram analisadas 36.125 referências dispostas em 1.462 artigos nas 10 revistas analisadas. Desse total, 4.242 (11,74% foram de periódicos nacionais. Não houve diferença significativa entre os dois períodos analisados. Artigos que citaram artigo de periódico nacional somaram 453 (30,98% artigos não citaram nenhum artigo de periódico nacional, enquanto 81 artigos (5,54% citaram mais artigos nacionais que estrangeiros. CONCLUSÃO: Do total de referências utilizadas, 11,74% foram referentes a artigos de periódicos brasileiros. Esse valor, quando comparado à porcentagem da produção brasileira no mundo na área de medicina, demonstra uma boa citação dos artigos nacionais.

  15. Publicações de enfermeiros sobre álcool e alcoolismo em anais do Congresso Brasileiro de Enfermagem

    Directory of Open Access Journals (Sweden)

    Divane de Vargas

    2013-06-01

    Full Text Available Este é um estudo exploratório, de cunho bibliográfico, cujo objetivo foi verificar e caracterizar a produção literária de enfermeiros sobre a temática álcool e alcoolismo publicada nos anais do Congresso Brasileiro de Enfermagem publicados no período de 1998 a 2008. A amostra constituiu-se de 99 resumos diretamente relacionados ao tema. Os dados foram categorizados segundo os pressupostos da análise de conteúdo e originaram sete categorias para análise. Evidenciou-se que houve um aumento da produção sobre a temática nos últimos cinco anos e que o atendimento ao paciente alcoolista foi o tema mais pesquisado pelos enfermeiros. Concluiu-se que, apesar do aumento da produção sobre o tema, esta ainda é incipiente e que outros estudos dessa natureza merecem ser realizados, de forma a mapear a produção da enfermagem divulgada nos eventos científicos da área.

  16. Turismo intervención publica en Canarias: transición del modelo cuantitivo al cuaitativo

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    Ramón Diaz Hernandez

    2008-09-01

    Full Text Available Confronté à une surfréquentation touristique, le Gouvernement local des Îles Canaries a publié un Arrêt (4/2001 qui reformule les Orientations Générales du Territoire et du Tourisme. L’objectif est de s’entendre sur les bases d’un modèle de développement insulaire soutenable, en mettant l’accent sur la gestion des ressources naturelles en général et le tourisme plus particulièrement. Cet Arrêt a été accompagné de normes dont l’objectif est de limiter la construction de nouveaux bâtiments hôteliers. Peu après, le Gouvernement a publié l’Arrêt 126/2001 qui limitait le développement touristique. Le Parlement adopta un autre Arrêt, la «Ley de Medidas Urgentes en Materia de Ordenación del Territorio y del Turismo de Canarias » (juillet 2001 qui détermine les conditions exigées aux établissements hôteliers de plus haute catégorie. Le Parlement donne aussi son accord à l’Arrêt 19/2003, «Directrices de Ordenación General y Directrices de Ordenación del Turismo de Canarias ».     Faced with excesses tourism, the local government of the Canary Islands issued a judgement (4 / 2001, which reformulates General Guidelines of Territory and Tourism. The aim is to set up the basis of a model of sustainable island development, with emphasis on natural resource management in general and tourism in particular. This decision was accompanied by standards whose objective is to limit the construction of new buildings for hotels. Shortly thereafter, the Government issued the ruling 126/2001 which limited the development of tourism. Parliament adopted another decree, "Ley de Medidas Urgent en Materia de Ordenación del Territorio y del Turismo de Canarias" (July 2001 which determines the conditions required for hotels higher category. The Parliament also gives its agreement to stop 19/2003, "Directrices de Ordenación General y Directrices de Ordenación del Turismo de Canarias."El desbordamiento ocasionado por el modelo desarrollista de nuestra economía dio lugar a que el gobierno canario promoviera el Decreto (4/2001 para formular las Directrices de Ordenación General y del Turismo por entender que el territorio y los recursos naturales, en general, y la actividad turística, en particular, precisaban de una acción que articulase la orientación del desarrollo insular hacia un modelo sostenible. Se acompañó esa intervención con una serie de medidas cautelares tendentes a congelar el crecimiento y suspender el otorgamiento de licencias para la creación de nuevos establecimientos turísticos alojativos. Poco después, el ejecutivo canario emitió el Decreto 126/2001 para contener el crecimiento, y, finalmente, el Parlamento aprueba y pone en vigor la Ley de Medidas Urgentes en Materia de Ordenación del Territorio y del Turismo de Canarias (julio, 2001 para regular las condiciones que deben reunir los establecimientos de la modalidad hotelera con la máxima categoría.  Por último, los diputados regionales dan el visto bueno a la Ley 19/2003 de Directrices  de Ordenación General y las Directrices de Ordenación del Turismo de Canarias.

  17. Research production among students from the Facultad Nacional de Salud Publica, Universidad de Antioquia, during the period 2004-2008

    Directory of Open Access Journals (Sweden)

    Camilo Noreña H

    2011-05-01

    Full Text Available Objective: to describe the research production of undergraduate students from the National Faculty of Public Health (Facultad Nacional de Salud Pública, FNSP, Universidad deAntioquia, during the period 2004-2008. Methods: descriptive study document review. The Study population was limited to graduation projects according to their different modalities (research projects, development project and monographs of the three undergraduate programs at the FNSP and research papers published in the Revista Facultad Nacional de SaludPública during the period 2004-2008. The analysis unit was restricted to graduation projects that could be located at the FNSP library and research papers including undergraduatestudents as authors. Descriptive statistics were used for the analysis of the data collected. Results: a total amount of 279 graduation projects were reviewed, from wich 119 (42.7% were research projects. In the undergraduate program of Management of Health Information Systems, research projects were the most frequent type of graduation project (79.1%. This proportion was smaller in the health administration programs both in its emphasis in health services (36.2% and in its emphasis on environment and sanitation (19.7%. A total amount of 126 research papers were reviewd finding 22 (17.5% with undergraduate students of the FNSP as coauthors. The proportion of research projects published in the Revista FNSP was 11.8%. Conclusions: during the period2004-2008, two out of five graduation projects in the FNSPwere research projects. During the period studied important differences according to the undergraduate programs were observed. The proportion of research projects published in the Revista FNSP is still very small.

  18. Analysis of public policies for new renewable energy in Brazil; Analise de politicas publicas para novas energias renovaveis no Brasil

    Energy Technology Data Exchange (ETDEWEB)

    Furtado, M.C.; Fadigas, E.A.F.A.; Baitelo, R.L. [Universidade de Sao Paulo (USP), SP (Brazil). Escola Politecnica

    2010-07-01

    Renewable energy have a prominent place among the solutions to combat global warming, but its potential is still untapped in Brazil. Without long-term policies with clear rules, you can not attract entrepreneurs and ensure stability of operation of this market. The main tools of government to promote renewable energy generation have not been efficient - the Incentive Program for Alternative Sources of Energy (Proinfa) was implemented in 2002 but put into operation just over two thirds of the energy proposal. The low success rate in repeated auctions focused on renewable energy. The objective of this paper is to discuss the prospects of the expansion of electricity generation by renewable energies in Brazil and some fundamental requirements for effective structuring of this market in the country. This argument is supported by the analysis of the proposed mechanisms used internationally and in the country, under a new law for renewable energies. As a practical demonstration of the analysis, we present a simulation of conditions of formation of the final price of renewable resources in different conditions as varied market rate of return, cost of transmission, and sale of carbon credits.

  19. Ensino à Distância: Uma Década das Publicações Científicas Brasileiras

    Directory of Open Access Journals (Sweden)

    Eliana Santos

    2009-01-01

    Full Text Available This study aimed to evaluate and trace the profile of the Brazilian scientific production for one decade (1997-2006 about e-learning through summaries of texts published in four databases indexed in the BVS-Psi. The analysis of the enclosed texts (N=52 in this study was given according to characteristic of authorship, sampling, among others. A light peak of production was seen in 2006 (19.23%. The authors matched in unique (n=28; 53.85% and multiple (n=23; 44.23%, differing only in the gender of the authors. More texts from research was observed (n=24;46.15%, with prominence for the Health Science area (n=14; 26.92%, as well studies with adults (n=29; 55,77%, On the other hand (n=46; 88,46% it was observed that the e-learning is stronger mainly in the academic scope. However, the publications related to this thematic, curiously, are not predominantly from Educational and Psychology professionals.

  20. Influence of communication on public opinion about nuclear energy; Influencia da comunicacao na aceitacao publica da energia nuclear

    Energy Technology Data Exchange (ETDEWEB)

    Carvalho, Everton de Almeida [ELETROBRAS Termonuclear S.A., (ELETRONUCLEAR), Rio de Janeiro, RJ (Brazil)

    1997-12-31

    Public opinion on risks and benefits associated to nuclear energy is depending on psychological and social factors and mainly on the communication strategy used to transfer knowledge and facts about nuclear technology to the public. In this work, the individual and collective communication process and the influences on the public opinion on nuclear energy will be analyzed. (author) 3 refs., 1 fig.

  1. Socioeconomic aspects and public opinion concerning radioactive wastes; Aspectos socieconomicos y de opinion publica en emplazamientos para residuos radiactivos

    Energy Technology Data Exchange (ETDEWEB)

    Gonzalez, Valentin [Empresa Nacional de Residuos Radiactivos (ENRESA) (Spain)

    1997-12-31

    Nuclear energy aspects in Spain are presented. The role of ENRESA (Empresa Nacional de Residuos Radiactivos, S.A.) a public company, that manages low and intermediate-level radioactive wastes in Spain is discussed. ENRESA activities such as radioactive wastes transportation and processing, radioactive wastes disposal, decommissioning of an uranium plant, environmental recovery procedures, geological studies, information dissemination of nuclear energy, sponsoring of conferences, courses, etc, are briefly reported

  2. Conexiones: Guia para Padres y Estudiantes. Directorio de Servicios y Programas de Educacion Especial de las Escuelas Publicas de Boston.

    Science.gov (United States)

    Celuzza, Paul W., Ed.; Clayton, Shelley Bakst, Ed.

    Intended for handicapped students and their parents, the booklet presents a guide in Spanish to special education services in the Boston public schools. Chapter 766, the Massachusetts law guaranteeing free appropriate public education to every child, is focused on. Section 1 discusses such evaluation aspects as early childhood screening, referral,…

  3. Las Nuevas Tecnologias de la Informacion en las Bibliotecas Publicas de Puerto Rico: Impacto en el Personal Bibliotecario

    Science.gov (United States)

    Diaz-Suarez, Damalin Judith

    2012-01-01

    The purpose of this research was to determine the status of Puerto Rico's public libraries to new information technologies. Obtaining the views of library staff working in the same, characteristics and attitudes and knowledge in new information technologies needed to serve as information specialists in libraries. To know the opinion of the…

  4. TABAGISMO NO BRASIL: AFERINDO O SUCESSO DAS POLÍTICAS PUBLICAS DE CONTROLE ENTRE 2006 A 2012

    Directory of Open Access Journals (Sweden)

    Kim Theodoro da Silva Rolim Cabral

    2017-05-01

    Full Text Available O tabagismo é o ato de consumir cigarros ou outros derivados de tabaco, cujo principal princípio ativo é a nicotina. O tabagismo é considerado uma doença crônica e a sua prevalência é considerada uma pandemia. Os usuários de tabaco são diariamente expostos a mais de 4 mil substâncias tóxicas sendo muitas dessas cancerígenas. Objetivo: Demonstrar índices de tabagismo durante os anos de 2006 a 2012 para avaliar a eficiência das ações governamentais contra o tabagismo. Metodologia: Trata-se de uma pesquisa quantitativa de caráter interpretativo e conclusivo. Resultados: o Ministério da Saúde tem valorizado a ação das equipes multidisciplinares que agem desde a prevenção contra o tabagismo até o processo de recuperação e tratamento da pessoa que deseja e tenta parar de fumar. Conclusão: Com a análise e interpretação destes dados pode-se afirmar que as políticas públicas antitabagismo têm apresentado contribuições reais para a diminuição do tabagismo no Brasil, nesta estratégia o Ministério da Saúde tem valorizado a ação das equipes multidisciplinares que agem desde a prevenção contra o tabagismo até o processo de recuperação e tratamento da pessoa que deseja e tenta parar de fumar.

  5. La escuela publica en Mexico y la definición incierta de la nación

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    Inés Castro

    Full Text Available La escuela en México siempre estuvo bajo el discurso de la integración, la homogenización y la construcción de la identidad nacional. El interés era dar continuidad a la cultura occidental europea, filtrada por las singularidades hispánicas y penetradas por el reconocimiento idealizado de lo autóctono (pueblos originarios. Sin embargo, el crecimiento de la pobreza, sumado a la permanencia de tendencias históricas discriminatorias en términos étnicos que se enfrentan al discurso cada vez más ampliado de respecto a los derechos humanos contraponen una realidad que invalida el logro de los objetivos originales de la escuela. En la última década surgen con fuerza las ideas de pluriculturalidad, como posiciones que desean integrar y renovar de alguna manera las propuestas escolares. Estas derivan del reconocimiento cada vez más expandido que se otorga a la diversidad cultural y de las deficiencias del proyecto del mestizaje cultural implementado en el país en períodos anteriores, que abogaba por una integración cultural casi "forzosa" que no resultó posible.

  6. Shallow Geothermal energy use in Public works; Aprovechamiento de la energia geotermica superficial en la obra publica

    Energy Technology Data Exchange (ETDEWEB)

    Santiago Buey, C. de; Pardo de Santayana Carrillo, F.

    2009-07-01

    Geothermal resources represent a great potential of directly usable energy, especially in connection with foundations and heat pumps, Since the beginning of the 1980s geothermal energy has also been increasingly obtained through foundation elements in some countries as Austria and switzerland. this innovation makes use of the high thermal storage capacity of concrete. energy foundations and other thermo-active ground structures mainly consist of earth-contact concrete elements (diaphragm walls, basement slabs or walls, tunnel linings) that are already required for structural reasons, but which simultaneously work as heat exchange after the installation of absorber pipes filled with a heat carrier fluid. This paper focuses in the current state of geothermal energy applications related to transport infrastructure and public works in general. Real cases on geothermal installations for heating systems in railway stations and tunnels, snow melting systems for roads, bridges, railways platforms and runways at airports are presented in this review. finally, two additional possibilities are briefly explained: Underground Thermal Energy Storage systems (UTES) and geothermal desalinisation systems. (Author) 41 refs.

  7. ESTRATEGIAS DE ACCION E INCIDENCIA EN LAS POLITICAS PUBLICAS DE LAS COOPERATIVAS DE TERCER GRADO EN ARGENTINA

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    María Cristina Acosta

    2011-01-01

    Full Text Available Este trabajo indaga sobre la incidencia de las entidades representativas del cooperativismo argentino en las políticas públicas contemporáneas. Se presenta un estudio de caso de las dos más importantes cooperativas de tercer grado del país, se analizan sus metas y estrategias en las interacciones con las dependencias estatales. Los resultados de las acciones de los actores definen metas y estrategias que pueden ser convergentes y/o divergentes. Se concluye que los vínculos que han construido las confederaciones seleccionadas con el Estado presentan características de complementación y cooperación en términos generales. Asimismo, la facultad de las organizaciones estudiadas para incidir en la definición de las políticas públicas resulta no solamente de los recursos propios, sino, principalmente, de las oportunidades políticas y la capacidad de establecer alianzas inter-actorales mediante estrategias colectivas.

  8. Use of colliery spoil in public works. La utilizacion de esteriles de la mineria del carbon en obras publicas

    Energy Technology Data Exchange (ETDEWEB)

    Gonzalez Canibano, J.; Rodriguez Ortiz, J.M. (HUNOSA, Oviedo (Spain))

    Colliery spoil presents a number of problems with regard to its storage because of the high cost involved, the difficulty of finding suitable land and its integration into the landscape. These factors are also affected by environmental legislation. One of the most interesting applications for colliery dirt is in the field of public works for in-filling operations, embankments, road building, dikes, etc., applications which require huge quantities of material without it needing to be processed. This article describes the physical and mechanical properties of colliery spoil from the point of view of its use in public works. 14 refs., 17 figs., 3 tabs.

  9. ¿Cambio cultural, posible o imposible? Orientaciones para el estudio de la Cultura Organizacional en la Administracion Publica Mexicana

    Directory of Open Access Journals (Sweden)

    Mendoza, J.

    2008-07-01

    Full Text Available This paper outlines the study of organizational culture and its changes in a context of public administration through the analysis of the implementation of civil service in the Mexican Public Administration. This conceptual development is elaborated to establish some explanations about the link between organizational culture and public administration. By analyzing this link, we establish the relevance of a theoretical approach to study organizational culture and its changes; thus, the influence of organizational culture on individual behavior in the organization is identified.

  10. Electric energy management - basis for a municipal public politics; Gestao da energia eletrica - bases para uma politica publica municipal

    Energy Technology Data Exchange (ETDEWEB)

    Kurahassi, Luiz Fernando

    2006-07-01

    Electricity is an input whose impact on the costs of the municipal public services varies according to the manner it is used and to the way it is obtained from the supplying company. The management of its use results in savings and in greater efficiency and quality of the delivered services - including the public lighting - besides, it softens environmental impacts and develops actions to orientate society towards energy-efficient consumption habits. The public sector has a significant share in the electricity final consumption in Brazil, trending to increase, but a room for consumption reduction and increase in energy efficiency can be seen in the municipalities. The purpose of this thesis is to identify concepts and set parameters that can be the basis of a public policy on electrical power management at the ambit of municipality. This paper reports a series of theoretical studies and empirical researches concerning the efficient use of electrical power in public services in cities of different countries and analyses the results reached from the application of models that successively work in the reality of cities from the Sao Paulo metropolitan area. It concludes that the municipality must play a role much more relevant than being a simple institutional electricity consumer, by proposing the basis for an intervention in the municipal reality. (author)

  11. Public perception of nuclear power in Mexico after Fukushima; Percepcion publica de la energia nuclear en Mexico despues de Fukushima

    Energy Technology Data Exchange (ETDEWEB)

    Palacios, J. C.; Alonso, G.; Ramirez, R., E-mail: javier.palacios@inin.gob.mx [ININ, Carretera Mexico-Toluca s/n, 52750 Ocoyoacac, Estado de Mexico (Mexico)

    2015-09-15

    This section presents some of the results of four studies on international public opinion about nuclear energy, the first one made several years before the Fukushima accident, conducted in 2005 by the IAEA through the company Globe Scan Inc. The second study was conducted by the same company in 2011 a few months after the Fukushima accident, including also corresponding results to two studies conducted by the British firm Ipsos Mori (of years 2011 and 2012 respectively). Finally three studies conducted by the Instituto Nacional de Investigaciones Nucleares (ININ) in 2006, 2008 and 2013 are presented. From the results of these studies was determined that the Fukushima accident itself had a negative effect on public opinion in Mexico, as throughout the world, but this trend is reversing. Also it found that public opinion in Mexico on using reactors to generate electricity is favorable, although not still has much support from the government for the construction of new nuclear power plants. (Author)

  12. Drogas na adolescencia : analise do uso de substancia quimicas entre adolescentes estudantes de escolas publicas e particulares de Campinas, SP

    OpenAIRE

    Maria Alice de Araujo Armani

    2007-01-01

    Resumo: Objetivo: Pesquisar, entre adolescentes de diferentes níveis sócio-culturais, estudantes de escolas públicas e privadas, uso de medicações específicas (fórmulas laboratoriais que visam emagrecimento, inibidores do apetite, ?orlistat?, anabólicos e esteróides, laxantes, diuréticos), tabagismo, consumo de bebidas alcoólicas, início de vida sexual, prevenção de gestações e DST e utilização de métodos anticoncepcionais. Métodos: Foi realizada uma pesquisa entre adolescentes estudantes do...

  13. Public Perception of Climate Change and Mitigation Technologies; Percepcion Publica del Cambio Climatico y las Tecnologias de Mitigacion

    Energy Technology Data Exchange (ETDEWEB)

    Sola, R; Sala, R; Oltra, C

    2007-09-27

    Public perception and understanding of climate change and mitigation policies may have a significant influence on the development of political programs as well as on individual behavioral intentions to address climate change. The study of public attitudes and beliefs about climate change and energy policy may be useful in the design of suitable communication strategies and in the efficient implementation of climate change mitigation and adaptation strategies. Based on a survey to the Spanish population, we analyze different issues such as the level of concern towards climate change, the existing knowledge about the contribution of different energy technologies to global warming, the attitudes toward energy technologies and the beliefs about potential adaptation strategies. Comparisons with other countries based on similar public opinion surveys are established to obtain a broader view of policy preferences and attitudes regarding climate change. (Author) 5 refs.

  14. Creator of Economic Opera, Founder and Reformer of Economic School – the Rector Paul Bran

    Directory of Open Access Journals (Sweden)

    Ghenadie Ciobanu

    2014-05-01

    Full Text Available Phd. Prof. Paul Bran (1940-2006, during the mandates of rector of the Bucharest University of Economic Studies (1996-2004 and beyond, although financier proved close to the Faculty of Commerce. In 2001, at the jubilee of the uninterrupted operation of the faculty, he stated: We join alumni, students and professors of the Faculty of Commerce to pay tribute to the work of learning and education that takes place here and to honor those who have established and then strengthened higher economic education in trade, marketing, tourism and commodity. I am convinced that the reputation of the Bucharest University of Economic Studies is due mainly to the quality of the activities taking place in departments and laboratories of the Faculty of Commerce.” On another occasion, the dedication on a book, he wrote: “Because tourism lives by money and money through tourism.” There are only two instances, seemingly unimportant, but which can be multiplied to the whole of his professional career of over four decades, and they shows us the Professor and Rector Paul Bran – both charismatic and effective – as a friend of the Faculty of Commerce. “Sincere congratulations and best wishes on the first issue of the journal Amfiteatru Economic,” said Rector Paul Bran, visionary, on the cover of the first issue of our publication, in 1999.

  15. African therapy for a fractured world(view): The life of founder bishop ...

    African Journals Online (AJOL)

    2015-06-26

    Jun 26, 2015 ... spirit-matter worldview. Read online: ... liturgical rituals to be found in this church, and his life story, or rather stories, are also still exercising that role after ..... Indians, Blacks and others, and that is where they met each other.

  16. Founder effect in 20 Afrikaner kindreds with pse·udoxanthoma ...

    African Journals Online (AJOL)

    1991-01-05

    Jan 5, 1991 ... geographical reasons the Mrikaner is an isolate population. Department of Medical Genealogy, Institute for Biostatis- tics ofthe South Mrican Medical Research Council, Parow- vallei, CP. M. TORRINGTON, D. PHIL. Department of Human Genetics and MRC Unit for. Inherited Skeletal Disorders, University ...

  17. High genetic diversity and absence of founder effects in a worldwide aquatic invader.

    Science.gov (United States)

    Lejeusne, Christophe; Saunier, Alice; Petit, Nicolas; Béguer, Mélanie; Otani, Michio; Carlton, James T; Rico, Ciro; Green, Andy J

    2014-07-24

    The introduced oriental shrimp Palaemon macrodactylus has recently become widespread in temperate estuaries worldwide. However, this recent worldwide spread outside of its native range arises after a previous introduction to the US Pacific coast, where it was restricted for more than 30 years. Using a phylogeographic approach, the present work investigates the genetic history of the invasion of this decapod worldwide. Japan acted as the main native source area for worldwide introduced populations, but other native areas (likely South Korea and China) may act as source populations as well. The recently introduced European and NW Atlantic populations result from colonization from both Japan and an unknown area of the native range, although colonization from the NE Pacific could not be ruled out. Most introduced populations had higher haplotypic diversity than most native populations. P. macrodactylus has a strong potential to become one of the most widespread introduced species and may become the dominant estuarine shrimp in Europe. The ecological and economic consequences of this invasion remain to be thoroughly evaluated.

  18. Social Entrepreneurship As Competence For Founders Of Social Enterprises In Romania And The Netherlands

    NARCIS (Netherlands)

    Joop Vinke; Loredana Orhei; S. Nandram

    2013-01-01

    Social entrepreneurship is currently at an early stage of knowledge development, both on the European Continent, as well as internationally. To a large extent, studies originate from theory, are based on small-scale individual case studies or have identified social entrepreneurship based on an

  19. A homozygous PMS2 founder mutation with an attenuated constitutional mismatch repair deficiency phenotype.

    Science.gov (United States)

    Li, Lili; Hamel, Nancy; Baker, Kristi; McGuffin, Michael J; Couillard, Martin; Gologan, Adrian; Marcus, Victoria A; Chodirker, Bernard; Chudley, Albert; Stefanovici, Camelia; Durandy, Anne; Hegele, Robert A; Feng, Bing-Jian; Goldgar, David E; Zhu, Jun; De Rosa, Marina; Gruber, Stephen B; Wimmer, Katharina; Young, Barbara; Chong, George; Tischkowitz, Marc D; Foulkes, William D

    2015-05-01

    Inherited mutations in DNA mismatch repair genes predispose to different cancer syndromes depending on whether they are mono-allelic or bi-allelic. This supports a causal relationship between expression level in the germline and phenotype variation. As a model to study this relationship, our study aimed to define the pathogenic characteristics of a recurrent homozygous coding variant in PMS2 displaying an attenuated phenotype identified by clinical genetic testing in seven Inuit families from Northern Quebec. Pathogenic characteristics of the PMS2 mutation NM_000535.5:c.2002A>G were studied using genotype-phenotype correlation, single-molecule expression detection and single genome microsatellite instability analysis. This PMS2 mutation generates a de novo splice site that competes with the authentic site. In homozygotes, expression of the full-length protein is reduced to a level barely detectable by conventional diagnostics. Median age at primary cancer diagnosis is 22 years among 13 NM_000535.5:c.2002A>G homozygotes, versus 8 years in individuals carrying bi-allelic truncating mutations. Residual expression of full-length PMS2 transcript was detected in normal tissues from homozygotes with cancers in their 20s. Our genotype-phenotype study of c.2002A>G illustrates that an extremely low level of PMS2 expression likely delays cancer onset, a feature that could be exploited in cancer preventive intervention. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  20. Founders, Finding, Being Found: Women's Wisdom in Teaching and Learning in Theology and Religion

    Science.gov (United States)

    Hess, Lisa M.; Brosmer, Mary Pierce; Moore, Mary Elizabeth Mullino

    2015-01-01

    This is an edited transcript of a conversation between two founding women on the delights and demands of teaching and learning within and beyond traditional institutional life, facilitated by Lisa M. Hess of the journal's Editorial Board. The conscious feminine practices of a women's writing school, Women Writing for (a) Change (Cincinnati, Ohio),…

  1. A Dutch Fanconi Anemia FANCC Founder Mutation in Canadian Manitoba Mennonites

    NARCIS (Netherlands)

    de Vries, Yne; Lwiwski, Nikki; Levitus, Marieke; Kuyt, Bertus; Israels, Sara J.; Arwert, Fré; Zwaan, Michel; Greenberg, Cheryl R.; Alter, Blanche P.; Joenje, Hans; Meijers-Heijboer, Hanne

    2012-01-01

    Fanconi anemia (FA) is a recessive DNA instability disorder associated with developmental abnormalities, bone marrow failure, and a predisposition to cancer. Based on their sensitivity to DNA cross-linking agents, FA cells have been assigned to 15 complementation groups, and the associated genes

  2. Commemorating Geoffrey Raisman: a great neuroscientist and one of the founders of neurorestoratology and the IANR

    Directory of Open Access Journals (Sweden)

    Li Y

    2018-03-01

    Full Text Available Ying Li,1 Pawel Tabakow,2 Daqing Li,1 Hongyun Huang3 On behalf of the International Association of Neurorestoratology 1Spinal Repair Unit, Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, UK; 2Department of Neurosurgery, Wroclaw Medical University, Wroclaw, Poland; 3Institute of Neurorestoratology, General Hospital of Armed Police Forces, Beijing, People’s Republic of China One year ago (January 27, 2017, the sad news that Life Honorary President of the International Association of Neurorestoratology (IANR, Geoffrey Raisman (Figure 1 had passed away shocked all our association members. We could hardly hide our grief. Besides expressing our grief and condolences to his wife, Vivian; his daughter, Ruth; and all his family, the Core Administration members communicated among each other via email and made a proposal to rename the Youth Forum of the Annual Conference, to the Raisman Youth Forum of the Annual Conference. The fourth IANR Council Board meeting in Argentina on September 29, 2017 approved this motion, and decided to establish the Raisman Neurorestoratology Foundation and to write an article commemorating him to be published in the Journal of Neurorestoratology. This commemorative article is divided into three parts: 1 his students and colleagues Daqing Li and Ying Li introduce his life and work; 2 his collaborating partner Pawel Tabakow introduces the process of their clinical trial; and 3 Hongyun Huang on behalf of the IANR introduces Geoffrey Raisman’s contribution to neurorestoratology and IANR. All individuals in the included images have provided written informed consent for the images to be published. 

  3. Genetic screening of the FLCN gene identify six novel variants and a Danish founder mutation

    DEFF Research Database (Denmark)

    Rossing, Maria; Albrechtsen, Anders; Skytte, Anne-Bine

    2016-01-01

    Pathogenic germline mutations in the folliculin (FLCN) tumor suppressor gene predispose to Birt-Hogg-Dubé (BHD) syndrome, a rare disease characterized by the development of cutaneous hamartomas (fibrofolliculomas), multiple lung cysts, spontaneous pneumothoraces and renal cell cancer. In this stu...... understanding of BHD syndrome and management of BHD patients.Journal of Human Genetics advance online publication, 13 October 2016; doi:10.1038/jhg.2016.118....

  4. [Doctor Levi B. Salmans, founder of The Good Samaritan sanitarium in Guanajuato].

    Science.gov (United States)

    Olivier-Toledo, Carlos; Viesca-Treviño, Carlos

    2016-01-01

    In this research we focus on the medical evangelist Levi B. Salmans, and The Good Samaritan sanitarium. Doctor Salmans lived in Mexico for about 50 years (1885-1935). During the first part of his stay, he was devoted to found churches and Methodist schools. However, from 1891 he took a turn in his career by founding dispensaries in different towns of Guanajuato to create, in 1899, the private charity association for the sick and infirm The Good Samaritan. His intense, intellectual, and practical work led him to create health journals, to train nurses, and to promote physiotherapies in accordance with the science advances of that time. By itself, this research shows that the history of medicine in Mexico still has long way to go and that Protestant communities, in favor of modernity and scientific knowledge, took a big part in shaping the history of this discipline in Mexico.

  5. Family Business Succession: Founders from Disadvantaged Communities in South Africa--An Exploratory Study

    Science.gov (United States)

    Isaacs, Eslyn B. H.; Friedrich, Christian

    2011-01-01

    It is estimated that 50-70% of all South African businesses are family-owned and that these businesses form the backbone of the South African economy, their qualities providing stability and resilience in the changing society of the nation. Succession is one of the biggest challenges for family business owners. Research shows that only 33% of all…

  6. From concept to certification; interview with AD&C co-founder and CEO Marcus Basien

    NARCIS (Netherlands)

    L'Ortye, J.; Spranger, L.

    2013-01-01

    Before any aircraft concept takes to the sky, air travel authorities require the aircraft be certified. One would expect a big organisation like EASA would function like a centralised verification authority. However, small companies like Aircraft Design & Certification Ltd. offer certification

  7. The Founder's Lecture 2009: advances in imaging of osteoporosis and osteoarthritis

    International Nuclear Information System (INIS)

    Link, Thomas Marc

    2010-01-01

    The objective of this review article is to provide an update on new developments in imaging of osteoporosis and osteoarthritis over the past three decades. A literature review is presented that summarizes the highlights in the development of bone mineral density measurements, bone structure imaging, and vertebral fracture assessment in osteoporosis as well as MR-based semiquantitative assessment of osteoarthritis and quantitative cartilage matrix imaging. This review focuses on techniques that have impacted patient management and therapeutic decision making or that potentially will affect patient care in the near future. Results of pertinent studies are presented and used for illustration. In summary, novel developments have significantly impacted imaging of osteoporosis and osteoarthritis over the past three decades. (orig.)

  8. Social Entrepreneurship Competence: Evidence from Founders of Social Enterprises in Romania

    NARCIS (Netherlands)

    Loredana Orhei; Joop Vinke; S. Nandram

    2014-01-01

    Social entrepreneurship has been defined until now by borrowing insights from commercial, Schumpeterian entrepreneurship as well as a new way of looking at non-profit work (Peredo and McLean, 2006; Short et al., 2009). Inspired by the use of a competence perspective to define entrepreneurship

  9. Virtual School Startups: Founder Processes in American K-12 Public Virtual Schools

    Science.gov (United States)

    Taylor, Brett D.; McNair, Delores E.

    2018-01-01

    Traditional school districts do not have a lot of experience with virtual schools and have lost students to state and charter virtual schools. To retain students and offer alternative learning opportunities, more public districts are starting their own virtual schools. This study was an examination of foundational processes at three California…

  10. Distribution and medical impact of loss-of-function variants in the Finnish founder population

    NARCIS (Netherlands)

    Lim, Elaine T.; Würtz, Peter; Havulinna, Aki S.; Palta, Priit; Tukiainen, Taru; Rehnström, Karola; Esko, Tõnu; Mägi, Reedik; Inouye, Michael; Lappalainen, Tuuli; Chan, Yingleong; Salem, Rany M.; Lek, Monkol; Flannick, Jason; Sim, Xueling; Manning, Alisa; Ladenvall, Claes; Bumpstead, Suzannah; Hämäläinen, Eija; Aalto, Kristiina; Maksimow, Mikael; Salmi, Marko; Blankenberg, Stefan; Ardissino, Diego; Shah, Svati; Horne, Benjamin; McPherson, Ruth; Hovingh, Gerald K.; Reilly, Muredach P.; Watkins, Hugh; Goel, Anuj; Farrall, Martin; Girelli, Domenico; Reiner, Alex P.; Stitziel, Nathan O.; Kathiresan, Sekar; Gabriel, Stacey; Barrett, Jeffrey C.; Lehtimäki, Terho; Laakso, Markku; Groop, Leif; Kaprio, Jaakko; Perola, Markus; McCarthy, Mark I.; Boehnke, Michael; Altshuler, David M.; Lindgren, Cecilia M.; Hirschhorn, Joel N.; Metspalu, Andres; Freimer, Nelson B.; Zeller, Tanja; Jalkanen, Sirpa; Koskinen, Seppo; Raitakari, Olli; Durbin, Richard; MacArthur, Daniel G.; Salomaa, Veikko; Ripatti, Samuli; Daly, Mark J.; Palotie, Aarno

    2014-01-01

    Exome sequencing studies in complex diseases are challenged by the allelic heterogeneity, large number and modest effect sizes of associated variants on disease risk and the presence of large numbers of neutral variants, even in phenotypically relevant genes. Isolated populations with recent

  11. A Founder Mutation in VPS11 Causes an Autosomal Recessive Leukoencephalopathy Linked to Autophagic Defects.

    Directory of Open Access Journals (Sweden)

    Jinglan Zhang

    2016-04-01

    Full Text Available Genetic leukoencephalopathies (gLEs are a group of heterogeneous disorders with white matter abnormalities affecting the central nervous system (CNS. The causative mutation in ~50% of gLEs is unknown. Using whole exome sequencing (WES, we identified homozygosity for a missense variant, VPS11: c.2536T>G (p.C846G, as the genetic cause of a leukoencephalopathy syndrome in five individuals from three unrelated Ashkenazi Jewish (AJ families. All five patients exhibited highly concordant disease progression characterized by infantile onset leukoencephalopathy with brain white matter abnormalities, severe motor impairment, cortical blindness, intellectual disability, and seizures. The carrier frequency of the VPS11: c.2536T>G variant is 1:250 in the AJ population (n = 2,026. VPS11 protein is a core component of HOPS (homotypic fusion and protein sorting and CORVET (class C core vacuole/endosome tethering protein complexes involved in membrane trafficking and fusion of the lysosomes and endosomes. The cysteine 846 resides in an evolutionarily conserved cysteine-rich RING-H2 domain in carboxyl terminal regions of VPS11 proteins. Our data shows that the C846G mutation causes aberrant ubiquitination and accelerated turnover of VPS11 protein as well as compromised VPS11-VPS18 complex assembly, suggesting a loss of function in the mutant protein. Reduced VPS11 expression leads to an impaired autophagic activity in human cells. Importantly, zebrafish harboring a vps11 mutation with truncated RING-H2 domain demonstrated a significant reduction in CNS myelination following extensive neuronal death in the hindbrain and midbrain. Thus, our study reveals a defect in VPS11 as the underlying etiology for an autosomal recessive leukoencephalopathy disorder associated with a dysfunctional autophagy-lysosome trafficking pathway.

  12. Professor Horia Hulubei, the father founder of the Institute of Atomic Physics

    International Nuclear Information System (INIS)

    Stratan, G.

    2000-01-01

    A hero of WW 1, Horia Hulubei (b. November 15, 1896, d. November 22, 1972), was one of the most prominent Romanian scientists of all time, leader and teacher of several generations of Romanian scientists during more than four decades. Graduated from Jassy University, he took his PhD. in Paris with Marie Curie and Jean Perrin in 1933. A few years later, Horia Hulubei was nominated Directeur de Recherches at the French National Centre of Scientific Research and elected Corresponding Member of Paris Academy of Sciences. Back in Romania, Hulubei was nominated professor and Rector of Bucharest University (1941). Professor Hulubei had a broad field of interests, from Classical to Atomic and Nuclear Physics, but his main achievements are connected with the Physics of X-rays (the first spectra of noble gases, the multiple Compton effect, the search for elements 87 and 85, etc.). The Institute of Atomic Physics (IPA) in Bucharest (1949) was the third research institution founded and directed by him. Following Hulubei's initial design, IPA was, and, in spite of the past and actual difficulties, remains, the flagship of Romanian scientific research. Along the years, IPA influenced beneficially the development of the post-war Romania and established many collaborations abroad. (author)

  13. Sister Mary Emil Penet, I.H.M.: Founder of the Sister Formation Conference

    Science.gov (United States)

    Glisky, Joan

    2006-01-01

    Mary Emil Penet, I.H.M., (1916-2001) used her talents and charisma to shape the first national organization of American women religious, the Sister Formation Conference (SFC; 1954-1964), facilitating the integrated intellectual, spiritual, psychological, and professional development of vowed women religious. In the decade preceding Vatican II, her…

  14. Contribution of CYP1B1 mutations and founder effect to primary congenital glaucoma in Mexico.

    Science.gov (United States)

    Zenteno, Juan Carlos; Hernandez-Merino, Elena; Mejia-Lopez, Herlinda; Matías-Florentino, Margarita; Michel, Norma; Elizondo-Olascoaga, Celia; Korder-Ortega, Vincent; Casab-Rueda, Homero; Garcia-Ortiz, Jose Elias

    2008-01-01

    The frequency of primary congenital glaucoma (PCG)-causing CYP1B1 mutations varies importantly among distinct populations, ranging from 20% in Indonesians and Japanese to about 100% among the Saudi Arabians and Slovakian Gypsies. Thus, the molecular characterization of large groups of PCG from different ethnic backgrounds is important to establish the actual CYP1B1 contribution in specific populations. In this work, the molecular analysis of the CYP1B1 gene in a group of Mexican PCG patients is reported. Thirty unrelated Mexican patients fulfilling the clinical criteria for PCG were included. Two cases were familial and with proven consanguinity, originating from distinct regions of the country. Polymerase chain reaction amplification and direct automated sequencing of the CYP1B1 coding region was performed in each participating subject. An identical pathogenic CYP1B1 mutation was demonstrated in 2 unrelated PCG subjects. The mutation consisted of a homozygous G to A transition at nucleotide position 1505 in exon 3, which predicted a substitution of glutamic acid for lysine at residue 387 of the protein (E387K). In the remaining 28 PCG subjects, no deleterious mutations were identified. Both subjects with the E387K mutation shared a same haplotype for 5 CYP1B1 intragenic single nucleotide polymorphisms, indicating a common origin of the allele. Mexican patients with PCG are rarely (less than 10%) due to CYP1B1 mutations. Available data indicate that most of the non-Brazilian Latin American PCG patients investigated to date are not due to CYP1B1 defects. Populations with low incidence of CYP1B1 mutations are appropriate candidates for the identification of novel PCG-causing genes.

  15. Monod as the founder of a new discipline: local and international contexts.

    Science.gov (United States)

    de Chadarevian, Soraya

    2015-06-01

    Monod gained stature as an experimentalist and theorist as well as a discipline builder. The essay reviews the intimate connection of the intellectual and institutional projects in his career. A brief comparison with the development of the new science of molecular biology across the English Channel highlights the commonalities and specificities of the disciplinary projects in France and Britain and the role that individuals like Monod played in their formation. The article argues that there was not a single path that led to the rise of molecular biology. Rather individual initiatives and historical contingencies very much shaped local outcomes. Copyright © 2015 Académie des sciences. Published by Elsevier SAS. All rights reserved.

  16. On the Founder of the Skripou Church: Literary Trends in the Milieu of Photius

    Directory of Open Access Journals (Sweden)

    Oscar Prieto-Domínguez

    2013-02-01

    Full Text Available Leo’s dedicatory poem, inscribed in 873/4, with its classical allusions has affinities with the culture and circle of Photius, and so the author may be the protospatharios Leo addressed in Photius ep. 209.

  17. Founders hope new venture-capital fund will spur medical, biotechnology research

    Science.gov (United States)

    Gray, Charlotte

    1995-01-01

    Lack of a coherent industrial strategy and venture capital have hindered scientific researchers in Canada, but the Canadian Medical Discoveries Fund (CMDF) Inc. hopes to change that. Under the leadership of Dr. Henry Friesen, president of the Medical Research Council of Canada, and Dr. Calvin Stiller, head of the multiorgan transplant unit at University Hospital, London, Ont., the new fund proposes to invest in promising medical and biotechnology research companies in Canada. The research council's peerreview system gives the new fund scientific credibility.

  18. Density of founder cells affects spatial pattern formation and cooperation in Bacillus subtilis biofilms

    NARCIS (Netherlands)

    van Gestel, Jordi; Weissing, Franz J.; Kuipers, Oscar P.; Kovacs, Akos T.

    2014-01-01

    In nature, most bacteria live in surface-attached sedentary communities known as biofilms. Biofilms are often studied with respect to bacterial interactions. Many cells inhabiting biofilms are assumed to express 'cooperative traits', like the secretion of extracellular polysaccharides (EPS). These

  19. Founder event and its effect on genetic variation in translocated populations of noble crayfish (Astacus astacus)

    Czech Academy of Sciences Publication Activity Database

    Bláha, M.; Žurovcová, Martina; Kouba, A.; Policar, T.; Kozák, P.

    2016-01-01

    Roč. 57, č. 1 (2016), s. 99-106 ISSN 1234-1983 Grant - others:European Fund(CZ) CZ.1.07/2.3.00/30.0049; European Fund(CZ) CZ1.05/2.1.00/01.0024; GA ČR(CZ) GAP505/12/0545 Institutional support: RVO:60077344 Keywords : bottleneck * conservation * homozygote excess Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 1.655, year: 2016 http://link.springer.com/article/10.1007%2Fs13353-015-0296-3

  20. Friedrich Robert Helmert, founder of modern geodesy, on the occasion of the centenary of his death

    Science.gov (United States)

    Ihde, Johannes; Reinhold, Andreas

    2017-08-01

    Friedrich Robert Helmert died in Potsdam in 1917 at the age of 74 after serving for over 30 years as director of the Royal Prussian Geodetic Institute and of the Central Bureau of the Internationale Erdmessung, the forerunner of today's International Association of Geodesy. He dedicated his life and his scientific career to the field of geodesy. His teachings on theoretical and physical geodesy were incorporated into university curricula around the world and hence into international endeavours to measure planet Earth. The purpose of this article is to illustrate the impact he has had on the development of modern geodesy and on the related sciences.

  1. African therapy for a fractured world(view): The life of founder bishop ...

    African Journals Online (AJOL)

    ... is in essence aimed at healing in all its multifaceted dimensions, which includes healing from physical ailments, 'healing' from barrenness, healing from spirit possession to healing as (re-)incorporation of an individual into the larger group, the healing of a nation as well as healing from a dualistic spirit-matter worldview.

  2. Fragile X founder chromosomes in Italy: A few initial events and possible explanation for their heterogeneity

    Energy Technology Data Exchange (ETDEWEB)

    Chiurazzi, P.; Genuardi, M.; Kozak, L.; Neri, G. [Universita Cattolica and Centro Ricerche per la Disabilita Mentale e Motoria, Roma (Italy)] [and others

    1996-07-12

    A total of 137 fragile X and 235 control chromosomes from various regions of Italy were haplotyped by analyzing two neighbouring marker microsatellites, FRAXAC1 and DXS548. The number of CGG repeats at the 5{prime} end of the FMR1 gene was also assessed in 141 control chromosomes and correlated with their haplotypes. Significant linkage disequilibrium between some {open_quotes}major{close_quotes} haplotypes and fragile X was observed, while other {open_quotes}minor{close_quotes} haplotypes may have originated by subsequent mutation at the marker microsatellite loci and/or recombination between them. Recent evidence suggests that the initial mechanism leading to CGG instability might consist of rare (10{sup -6/-7}) CGG repeat slippage events and/or loss of a stabilizing AGG via A-to-C transversion. Also, the apparently high variety of fragile X chromosomes may be partly due to the relatively high mutation rate (10{sup -4/-5}) of the microsatellite markers used in haplotyping. Our fragile X sample also showed a higher than expected heterozygosity when compared to the control sample and we suggest that this might be explained by the chance occurrence of the few founding events on different chromosomes, irrespective of their actual frequency in the population. Alternatively, a local mechanism could enhance the microsatellite mutation rate only on fragile X chromosomes, or fragile X mutations might occur more frequently on certain background haplotypes. 59 refs., 4 figs.

  3. Local-scale invasion pathways and small founder numbers in introduced Sacramento pikeminnow (Ptychocheilus grandis)

    Science.gov (United States)

    Andrew P. Kinziger; Rodney J. Nakamoto; Bret C. Harvey

    2014-01-01

    Given the general pattern of invasions with severe ecological consequences commonly resulting from multiple introductions of large numbers of individuals on the intercontinental scale, we explored an example of a highly successful, ecologically significant invader introduced over a short distance, possibly via minimal propagule pressure. The Sacramento pikeminnow (

  4. Marian Smoluchowski as the founder of the physics of stochastic phenomena

    International Nuclear Information System (INIS)

    Chandrasekhar, S.

    1989-01-01

    This paper present a discussion on Marian Smoluchowski, the originator (along with Einstein) of the theory of Brownian motion; who gave the correct interpretation of the phenomenon of critical opalescence. The author focuses on a series of papers which Smoluchowski wrote in which the foundations of the modern theory of stochastic processes were laid and the related paradoxes of Loschmidt and Zermelo were discussed

  5. Dynamic genetic linkage of intermediate blood pressure phenotypes during postural adaptations in a founder population

    Science.gov (United States)

    Arenas, I. A.; Tremblay, J.; Deslauriers, B.; Sandoval, J.; Šeda, O.; Gaudet, D.; Merlo, E.; Kotchen, T.; Cowley, A. W.

    2013-01-01

    Blood pressure (BP) is a dynamic phenotype that varies rapidly to adjust to changing environmental conditions. Standing upright is a recent evolutionary trait, and genetic factors that influence postural adaptations may contribute to BP variability. We studied the effect of posture on the genetics of BP and intermediate BP phenotypes. We included 384 sib-pairs in 64 sib-ships from families ascertained by early-onset hypertension and dyslipidemia. Blood pressure, three hemodynamic and seven neuroendocrine intermediate BP phenotypes were measured with subjects lying supine and standing upright. The effect of posture on estimates of heritability and genetic covariance was investigated in full pedigrees. Linkage was conducted on 196 candidate genes by sib-pair analyses, and empirical estimates of significance were obtained. A permutation algorithm was implemented to study the postural effect on linkage. ADRA1A, APO, CAST, CORIN, CRHR1, EDNRB, FGF2, GC, GJA1, KCNB2, MMP3, NPY, NR3C2, PLN, TGFBR2, TNFRSF6, and TRHR showed evidence of linkage with any phenotype in the supine position and not upon standing, whereas AKR1B1, CD36, EDNRA, F5, MMP9, PKD2, PON1, PPARG, PPARGC1A, PRKCA, and RET were specifically linked to standing phenotypes. Genetic profiling was undertaken to show genetic interactions among intermediate BP phenotypes and genes specific to each posture. When investigators perform genetic studies exclusively on a single posture, important genetic components of BP are missed. Supine and standing BPs have distinct genetic signatures. Standardized maneuvers influence the results of genetic investigations into BP, thus reflecting its dynamic regulation. PMID:23269701

  6. Founder-specific inbreeding depression affects racing performance in Thoroughbred horses.

    Science.gov (United States)

    Todd, Evelyn T; Ho, Simon Y W; Thomson, Peter C; Ang, Rachel A; Velie, Brandon D; Hamilton, Natasha A

    2018-04-18

    The Thoroughbred horse has played an important role in both sporting and economic aspects of society since the establishment of the breed in the 1700s. The extensive pedigree and phenotypic information available for the Thoroughbred horse population provides a unique opportunity to examine the effects of 300 years of selective breeding on genetic load. By analysing the relationship between inbreeding and racing performance of 135,572 individuals, we found that selective breeding has not efficiently alleviated the Australian Thoroughbred population of its genetic load. However, we found evidence for purging in the population that might have improved racing performance over time. Over 80% of inbreeding in the contemporary population is accounted for by a small number of ancestors from the foundation of the breed. Inbreeding to these ancestors has variable effects on fitness, demonstrating that an understanding of the distribution of genetic load is important in improving the phenotypic value of a population in the future. Our findings hold value not only for Thoroughbred and other domestic breeds, but also for small and endangered populations where such comprehensive information is not available.

  7. Founders lecture 2007. Metabolic bone disease: what has changed in 30 years?

    Energy Technology Data Exchange (ETDEWEB)

    Sundaram, Murali [Cleveland Clinic, Diagnostic Radiology, MSK, Cleveland, OH (United States)

    2009-09-15

    To provide an update on imaging of metabolic bone disease based on new developments, findings, and changing practices over the past 30 years. Literature review of osteoporosis, osteomalacia, renal osteodystrophy, Paget's disease, bisphosphonates, with an emphasis on imaging. Cited references and pertinent findings. Significant developments have occurred in the imaging of metabolic bone disease over the past 30 years. (orig.)

  8. Resiliência: análise das publicações no período de 2000 a 2006

    Directory of Open Access Journals (Sweden)

    Marileide A. de Oliveira

    Full Text Available A resiliência é um fenômeno importante do desenvolvimento humano; no entanto, seu conceito encontra-se em fase de discussão, pois esse campo de pesquisa é recente na área das ciências humanas. O presente estudo teve como objetivo realizar um levantamento bibliográfico de pesquisas relacionadas à resiliência no período de 2000 a 2006. O método adotado compreendeu a análise documental, através do levantamento de pesquisas em bases de dados, com a utilização de palavras-chave. A análise dos dados consistiu na elaboração de categorias de análise tomando como base os resultados encontrados em pesquisas sobre resiliência. Os dados apontaram que há ênfase nas pesquisas básicas, prevalência de população de adultos nos estudos analisados e utilização da entrevista como principal instrumento. Os resultados também indicam que o conceito de resiliência está em construção; além disso, a resiliência tem relação direta com os fatores de risco e de proteção e, por último, que é necessário o desenvolvimento de programas de prevenção e intervenção.

  9. Need for public participation in decision-making on energy; Necesidad de la participacion publica en la toma de decisiones en materia energetica

    Energy Technology Data Exchange (ETDEWEB)

    Norte Gomez, M. D.

    2014-07-01

    This paper outlines the need to expand and improve public participation in decision-making on energy. In an advanced society like ours you can not continue using the same tools they used a century ago. Provide and transmit by the scientific community to society, information science and technology in an appropriate language that comes to them, giving them opportunities and enabling them to participate objectively in this decision making. There must be a legitimate, honest, sincere and plural debate where the participation of all the actors involved and from all strata of society. (Author)

  10. Public Perception and Acceptance of Hydrogen Technologies. An Exploratory Study; Percepcin y Aceptacion Publica de las Tecnologias del Hidrogeno. Un Estudio Exploratorio

    Energy Technology Data Exchange (ETDEWEB)

    German, S; Navajas, J

    2011-11-10

    This report presents the results of a research study with lay peoples perception regarding hydrogen technologies. This study aims to explore how to shape public perception and acceptance of hydrogen technologies in Spain and permits the identification of issues that may facilitate or interfere with its development and implementation. The results showed the existence of a large and widespread lack of knowledge towards hydrogen technologies. Hydrogen is perceived as a clean energy technology and nearby to renewable energies. However, it is still not seen as an energetic option. The main drawbacks perceived by lay people have been the lack of profitability, the slow evolution of the technology and the absence of technological developments. Furthermore, hydrogen cost and safety issues appear to play an important role in public acceptance of these technologies. (Author) 35 refs.

  11. Quality of mammography equipment in Health Public Network; Calidad de proceso generador de imagenes mamograficas de equipos instalados en la Red Publica de Salud

    Energy Technology Data Exchange (ETDEWEB)

    Ruberti Filha, E. M.; Pires, S. R.; Medeiros, R. B.

    2006-07-01

    In spite of the requirements of the Brazilian Regulatory Organization to ensure that quality control verifications are made in the radiological equipment, further actions should also be carried out in order to guarantee the quality of the images and of the diagnosis. This study has as its objective to analyze the failures of the image generation system using instruments to control the quality of the radiological equipment, verify the processing image conditions and, finally, classify the mammographic findings as unacceptable, suitable and acceptable. A statistical phantom was used in which the fibers and the microcalcifications were randomly positioned. The images were then read by specialists and the level of agreement was measured by the Kappa value. It was possible to check that most of the tested equipment parameters presented a good performance, although the film processing did not generate satisfactory results and caused reading difficulties. Many of the results of these reading were classified as unacceptable. Among these images, only a small percentage of them presented the fibers and microcalcifications of the sizes required by the Brazilian legislation. We concluded that it is only possible to generate good quality images if all the steps of the process are properly controlled. Therefore, it is relevant to invest in training, calibration and maintenance of the mammographic equipment. (Author)

  12. Historia de la salud publica en México: siglos XIX y XX History of public health in Mexico: 19th and 20th centuries

    Directory of Open Access Journals (Sweden)

    Ana Cecilia Rodríguez de Romo

    1998-10-01

    Full Text Available A evolução da saúde pública mexicana foi gradual. Nos séculos XIX e XX desenvolveu-se paralelamente às mudanças políticas e sociais do país. Na primeira metade do século XIX o cuidado com os doentes dependia parcialmente da caridade religiosa. Depois, instituiu-se a beneficiência pública, consolidada pelo presidente Benito Juárez (1856, forma de atendimento continuada por Porfirio Díaz (1880-1910. A partir da Revolução (1910-1917 surgiu o princípio de assistência pública como obrigação do Estado para com a sociedade. Atualmente, a assistência à saúde, e a seguridade social conjugam-se em um conceito de medicina institucional que compreende a investigação, o ensino e os serviços prestados à sociedade. Este trabalho é uma análise do desenvolvimento da saúde pública mexicana nos dois últimos séculos. Faz referência às doenças e seu controle, ao aparecimento das instituições e à evolução do conceito de saúde pública na história mexicana.During the nineteenth and twentieth centuries, its growth accompanied the country’s political and social changes. In the early half of the nineteenth century, care for the sick depended in part on religious charity. So-called public beneficial care was later introduced and consolidated under president Benito Juárez (1856 and then continued under Porfirio Díaz (1880-1910. The Mexican Revolution (1910-1917 brought the notion that public-health assistance is the State’s social responsibility. Health care and social security are now both part of so-called "institutional medicine," which also encompasses research and teaching on public health. This analysis of public-health care in Mexico examines the question of diseases and their control, the emergence of institutions, and the development of the concept of public health.

  13. Energy efficiency programs in Brazil: formulation of public policy, planning and management; Programas de eficiencia energetica no Brasil: formulacao de politicas publicas, planejamento e gestao

    Energy Technology Data Exchange (ETDEWEB)

    Bajay, Sergio Valdir [Universidade Estadual de Campinas (NIPE/UNICAMP), SP (Brazil). Fac. de Engenharia Mecanica. Nucleo Interdisciplinar de Planejamento Energetico], email: bajay@fem.unicamp.br

    2010-07-01

    The Brazilian government never had a long-term policy for energy efficiency, with clearly defined energy conservation targets, implementation strategies, time schedules and responsibilities. The planning of energy efficiency programmes in the country is still in an early stage and the management of these programmes is far from satisfactory. A critical analysis of these three forms of federal government intervention in this area is carried out in this paper and several measures are proposed to the Ministry of Mines and Energy, some other ministries and to the Energy Research Company, which can increase substantially the adoption of new energy efficiency programmes in Brazil. (author)

  14. Economical evaluation of two public policies regarding water pollution control; Evaluacion economica de dos politicas publicas para controlar la contaminacion del agua

    Energy Technology Data Exchange (ETDEWEB)

    Gutierrez-Andrade, Miguel Angel [Universidad Autonoma Metropolitana-Iztapalapa (Mexico); Bravo-Perez, Hector Manuel [Centro de Investigacion y Docencia Economica (Mexico)

    2006-01-15

    Since Pigou proposed that the internalization of the negative externalities could be done calculating a tax in order to correct the difference between private costs and social costs; this will recover the conditions of economic efficiency in all the hydraulic legislations of the world, however, this advice has been applied in conditions of great shortage; it could be thought that to burden the consumptive use could be more suitable than to burden the production of residual water reaching this way not only the recovering of social efficiency but also a double dividend: to stimulate the water recycling. This work evaluates the effect that the tax to the consumptive use will have over a fake economy. The achieved results are compared using data from two economies with a different water production each one. The contrast is done using a model of computable general equilibrium with the Arrow-Debreu assumptions relaxed with the introduction of a government that collect the proposed taxes in a previously distorted economy. The collection distributes through a direct transference to the revenue of the consumers, the model calibrates and resolves following the methodology proposed by Shoven and Whalley (1984). [Spanish] Desde que Pigou propuso que la internalizacion de las externalidades negativas podria hacerse a traves de un impuesto que corrigiera la diferencia entre costos privados y costos sociales -de forma tal que se recuperaran las condiciones de eficiencia economica-, practicamente en todas las legislaciones hidraulicas del mundo se ha aplicado esta recomendacion; sin embargo, en condiciones de gran escasez de agua podria pensarse que gravar la cantidad de agua incorporada definitivamente al producto final, el uso consuntivo, podria ser mas adecuado que gravar la produccion de agua residual, pues asi se lograria, ademas de recuperar las condiciones de eficiencia social, un doble dividendo: incentivar el reciclaje del agua. En este trabajo se evalua el efecto que el cobro de un impuesto al uso consuntivo y a la produccion de agua residual tendria sobre una economia simplificada. Los resultados obtenidos se contrastan utilizando informacion de dos economias con dotaciones de agua muy diferentes. La comparacion se hace utilizando un modelo de equilibrio general computable del tipo Arrow-Debreu, considerando un gobierno que recauda los impuestos propuestos en una economia previamente distorsionada y distribuye la recaudacion via una transferencia directa al ingreso de los consumidores. El modelo se calibra y se resuelve siguiendo la metodologia propuesta por Shoven y Whalley (1984).

  15. La falta de financiacion publica hipoteca el futuro del acelerador de protones valenciano. La Universidad de Valencia tiene avanzado el diseno de este dispositivo de alta tecnologia

    CERN Multimedia

    Jatvia, J M

    2002-01-01

    "La Universidad de Valencia tiene avanzado el diseno de un acelerador lineal de protones, cuya culminacion depende del compromiso del Consell en sufragar la plantilla que necesitaria el centro para estar operativo" (1 page).

  16. Institutional opening: contribution to the public acceptance of the nuclear activities; Apertura institucional: una contribucion a la aceptacion publica de las actividades nucleares

    Energy Technology Data Exchange (ETDEWEB)

    Martin, Hugo R [Comision Nacional de Energia Atomica, Mendoza (Argentina). Regional Cuyo

    2003-07-01

    Activities that the National Atomic Energy Commission (CNEA) has carried out during a half century in Cordoba city show a long misunderstanding and confrontations with the provincial and municipal authorities, and with the neighbors and environmentalist antinuclear organizations. Most of the information that the people have received about the risks and benefits of the activities has generally been produced by the media. The media have always started the pressures on the political leadership and the government officials, to get measures on activities that are perceived as excessively dangerous. However the experience indicates that the demands for the protection of the health or the environment and sometimes the claiming for the closing of the facilities have been directly related with what people really know about the activities in the site. All that they know, comes from listening the radio and television or reading the newspapers. The common denominator that one observes in the conflicts of the past, is the high degree of ignorance on the part of the citizenship on the activities that are carried out in the place. This is valid for the neighbors of the place, for the competent authorities and even for the Cordoba's scientific and technical qualified community. From the analysis it also arises that the conflicts were originated by the absence of preventive actions to assist them properly (or to neutralize them in premature form) as well as for fair reasons related with unacceptable risks for the society. Finally the facts have demonstrated that the incompatibility among the reasoning of the technicians supporting their positions in rational arguments and the fundamentalism of the environmentalist's methodology using incomplete and emotional arguments, makes impossible a sustainable agreement for the development of the activities of the CNEA in Cordoba city. The origin of the conflicts are essentially two: the existence in the site of the residues of the minerals treated between 1954 and 1975 and the operation of the uranium oxide production plant of Dioxitek S.A. In the first case, the sole fact that there are 'residues' implies a negative connotation for the society. Their definitive uselessness and therefore the necessity of their elimination so soon and as far away as possible, is a natural perception in the population, also increased in this particular case for the use (and abusing in many opportunities) of the 'radioactive' or 'nuclear' adjectives. With them, a type of practically unknown risk is identified by the common man: the effects of the ionizing radiation on the life and the environment. In what concerns the operation of the plant, the doubts on possible accidents, or the final destination of their wastes and residues, is the main concern in the local community. On this background, during the year 2003, and taking into account the responsibility of informing the population on what is carried out in the facilities, the CNEA began a process of institutional opening. The legislators of the Commission of Ecological Matters of the Legislature of Cordoba, the members of educational centers and students of schools near to the site, officials of the municipal institutions, (Center of Communal Participation and Alta Cordoba Cultural Center), members of civil organizations with community ends (Association of Friends of the Belgrano Railways and Municipal Club) and neighbors have been invited to visit the site. The experience has shown to be doubly effective: on one hand the visitors manifested a clear support to the activities that are carried out in the site, ratifying their trust in the capacity of the CNEA to conduct them. On the other, the own personnel working in the place has appraised the importance that its daily work has for the society. (author)

  17. Tesis de la Facultad de Medicina: la cuti-reaccion de Von Pirquet y los alumnos de las escuelas publicas de Bogotá

    Directory of Open Access Journals (Sweden)

    Vicente Sáenz Caycedo

    1933-01-01

    limpiada con alcohol o éter y depositar luégo sobre ella una pequeña porción de Tuberculina; de doce a veinticuatro horas después se ha formado una pápula rojiza cuando la reacción es positiva, debida al estado alérgico del portador de bacilos vivos; y termina su trabajo con dos cuadros que condensan su experimentación sobre la Tuberculina en 3.166 niños de las Escuelas públicas de Bogotá, de ambos sexos y cuyas edades oscilaban Entre cinco y catorce años; los cuadros son los siguientes.

  18. A noção de couraça na obra de Wilhelm Reich: publicações de 1920 a 1933

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    Bruno Prates Almeida

    2014-08-01

    Full Text Available L'étude examine la notion de cuirasse dans les 13 premières années, de 1920 à 1933, de l'œuvre du psychanaliste Wilhelm Reich (1897-1957, période pendant laquelle l'auteur était membre de l'International Psychoanalytical Association [Association Internationale de Pschyanalyse]. Question directrice: quel est/ quels sont le/les sens de cuirasse dans la pensée de Reich? Méthode: nous menons des recherches sur les écrits de Reich, psychanalyste à cette époque-là, conformément à la séquence chronologique de la publication des travaux. Résultats: a la cuirasse est mentionnée pour la première fois en 1922, dans l'article Deux types narcissiques, pour indiquer une défense associée au cadre des névroses caractérielles; b en príncipe, elle est conçue dans la sphère psychique, mais graduellement, elle en vient à être considérée dans le cadre somatique également ; c destinée à exercer une fonction protectrice, la cuirasse constitue quelque chose de naturel et d'inévitable, cependant cette structure peut arriver à compromettre le contact avec le milieu interne et externe et elle affecte aussi la régulation libidinale du sujet.

  19. Public Perception of Carbon Capture and Storage. Qualitative Study Results; Percepcion Publica de la captura y almacenamiento de CO2. Resultados de un Estudio Cualitativo

    Energy Technology Data Exchange (ETDEWEB)

    Sola, R; Sala, R; Oltra, C

    2007-09-27

    In recent years, public perception and acceptance of Carbon Capture and Storage has become a key issue for research as technological projects have been initiated in USA, Canada and Europe. It has been considered that public opposition could be an important barrier for technological deployment. This report is part of the sub project Acceptability and Governance of CO2 storage processes, started in 2005 as a part of the technological project Advanced technologies of CO2 generation, capture and storage. The study is based on the application of focus groups with lay people. This qualitative social research technique was applied to get a deeper knowledge of the elements influencing the public acceptability of CO2 storage sites. Results indicate that there exists a low level of awareness about the technology among participants. After providing some information about the technology, the initial reaction stays between rejection and ambivalence. A reluctant acceptance appears when significant importance is given to the perceived benefits. The perception of risk from climate change plays an essential role. (Author) 25 refs.

  20. Publicação Científica Nacional e Internacional sobre Franchising: Levantamento e Análise do Período 1998 - 2007

    Directory of Open Access Journals (Sweden)

    Pedro Lucas de Resende Melo

    2010-03-01

    Full Text Available The franchising system generates about forty-six billion reais a year in the Brazilian economy by way of 1,197 franchising networks that licnse 65,500 units, generating almost 600,000 direct jobs. In the USA that number is higher still, with around 760,000 units that generate 1.53 trillion dollars a year in the economy. The objective of this paper is to develop an unpublished goal-analysis on franchising involving 61 Brazilian and international scientific papers published from 1998 to 2007 and published by Anpad and in related periodical in Proquest (Qualis A, B or C. Saint approached the following questions: how scientific research into franchises has developed; in which academic vehicles are they linked; the main themes that are dealt with; which institutions these authors are connected with; the participation of states and countries; the predominance of certain authors; the research methods used and the economic segments of application. The results show that Brazilian works are concentrated in Enanpad; the predominance of works on Entrepreneurship and Strategy, internationally, with focus in economic theories; most of the authors are connected to institutions in the south and south-east of Brazil and the USA; a strong predominance of the surveys and the application of the research in several sections of the economy.

  1. Apuntes sobre la utilidad de un modelo de competencias aplicado a los puestos de dirección en la Universidad Publica Costarricense

    OpenAIRE

    Warner Cascante Salas

    2003-01-01

    El modelo de competencia laboral es, en el ámbito mundial, una respuesta eficiente a las exigencias y ataques que reciben las Instituciones Estatales por parte de la Globalización. En Costa Rica, la Universidad Estatal forma parte del Servicio Público, y por esta razón, la Constitución Política impone como regla básica de la función de los Directores de las Unidades Académicas, la idoneidad comprobada. En este ensayo, se analiza el desarrollo del modelo de competencias como opción para legiti...

  2. Sustentabilidade e cadeia de suprimentos: uma perspectiva comparada de publicações nacionais e internacionais Sustainability in supply chains: a comparative perspective in domestic and international journals

    Directory of Open Access Journals (Sweden)

    Sylmara Lopes Francelino Gonçalves Dias

    2012-08-01

    Full Text Available O objetivo do artigo é apresentar um quadro de referência de conceitos da Gestão da Sustentabilidade na Cadeia de Suprimentos (GSCS para auxiliar pesquisas futuras na tentativa de integração intra e interorganizacional fundamentada em aspectos da sustentabilidade. Trata-se de um artigo teórico, cujo procedimento metodológico adotado foi o desk research em periódicos da área de gestão e operações, realizado em duas etapas. Na primeira, buscou-se visualizar os estudos da temática em seis importantes periódicos internacionais da área, totalizando 53 artigos entre 1954 e 2009. Esta etapa gerou uma evolução da temática, contribuindo para apontar tendências. Na segunda, foram revisados seis periódicos nacionais da área de administração. Selecionaram-se 11 artigos, publicados entre 1961 e 2009, resultando em um panorama da temática no contexto acadêmico brasileiro. O conceito de GSCS apareceu apenas em 2007, o que mostra a atualidade do tema, embora este seja a junção de temáticas anteriormente estudadas.This article provides a reference frame of concepts in Supply Chain Sustainability Management (SCSM, helping future research in the attempt to integrate intra and interorganizational choices based on the aspects of sustainability in supply chains. It is a theoretical study and the methodological procedure adopted was the desk research, organized in two steps. Firstly, the theme study was analyzed in six international journals, totaling 53 articles between 1954 and 2009. This step generated an evolution of the area, helping to pinpoint trends. Secondly, six domestic journals were reviewed and 11 articles were selected between 1961 and 2009, resulting in an overview of the theme in the Brazilian academic context. The concept of GSCS appeared only in 2007, which shows the relevance of the topic; although this is a gathering of topics previously studied separately.

  3. IL CONTRIBUTO DI INNOCENZO III ALLA FORMAZIONE DELLA CULTURA GIURIDICA OCCIDENTALE: IN PARTICOLARE IN RELAZIONE AL NOTO PRINCIPIO «REI PUBLICAE INTEREST NE CRIMINA REMANEANT IMPUNITA»

    Directory of Open Access Journals (Sweden)

    Cesare Edoardo Varalda

    2016-12-01

    Full Text Available Within the period so called renovatio, many principles contained in the Roman legal sources have been explained in a new and innovative way, influencing the history of juridical thought and contributing to the development of the European legal experience. In fact, the principle "Rei publice interest it crimina remaneant impunita" (mentioned in two decretals of Innocent III: i.e. the Inauditum in 1199 and i.e. the Ut famae in 1203 has an essential role in the development of the conceptual system of modern criminal law. The content of this study will be, on the one hand, the detailed study of historical iter by which this principle has been consolidated and has been embraced by canonical experience and, more generally, in the Western one; on the other hand, it will analyse both from a technical and a metagiuridico point of view the origin of such formula and on the contribution that Christian theology might have given by clarifying and specifying its meaning. Therefore, it’s clear the importance of this principle in the development of the European legal system and, broadly, in the Western legal experience.

  4. Depresión y factores socio demográficos asociados en estudiantes universitarios de ciencias de la salud de una universidad publica (Colombia)*

    OpenAIRE

    Ferrel Ortega, Robert F.; Celis Barros, Adela; Hernández Cantero, Olga

    2011-01-01

    Se trata de una investigación descriptiva, con diseño transversal, realizada con el objetivo identificar los niveles de depresión y factores sociodemográficos asociados, en 190 estudiantes de Psicología, Medicina, Odontología y Enfermería, de una Universidad Pública del Magdalena (35,8% hombres y 64,2% mujeres, media de 20,4 años y D.T. de 2,7). Se aplicó el "Inventario de Depresión de Beck" (BDI, Beck, Rush, Shaw y Emery, 1979) y se registraron datos sociodemográficos. Se halló que el 52% su...

  5. Public Perception of CCS Technology. The Effects of Information on Attitude; Percepcion Publica de la Tecnologia de CAC. El Efecto de la Informacion en la Actitud

    Energy Technology Data Exchange (ETDEWEB)

    Oltra, C.; Marin, R.; Sala, R.

    2011-11-10

    This report examines the public perception of Carbon Capture and Storage technology and the impacts of information on perception. We analyze, from an electronic questionnaire with technical and contextual information, dimensions such as the initial reaction to the technology, the acceptance of CO{sub 2} storage, the perception of risk of storage and the degree of antagonism toward the organizations involved. The determinants of attitudes and reactions to CCS are also analyzed. A favorable initial reaction to CCS is found after some information and contextualization of CCS as well as significant risk perception. The type of information transmitted appears to influence the attitude of participants to the technology. The broader positive impact on attitude occurs when transmitting the idea of CO{sub 2} as a natural resource. (Author) 4 refs.

  6. Organização e publicação dos termos do website da ANACOM sob uma perspetiva linked open data

    OpenAIRE

    Firmino, Helder Noel Monteiro

    2013-01-01

    Dissertação de mestrado em Engenharia e Gestão de Sistemas de Informação O propósito da Web Semântica é conseguir uma Web de dados totalmente ligada, isto é, numa perspetiva Linked Open Data. A Web Semântica deve garantir (estabelecendo padrões tecnológicos, vocabulários, linguagens lógicas, etc.) que os conteúdos publicados na Web sejam inteligíveis quer por agentes humanos, quer por agentes máquina. Esta dissertação tem como objetivo responder à um problema delimitado, propon...

  7. Apuntes sobre la utilidad de un modelo de competencias aplicado a los puestos de dirección en la Universidad Publica Costarricense

    Directory of Open Access Journals (Sweden)

    Warner Cascante Salas

    2003-01-01

    Full Text Available El modelo de competencia laboral es, en el ámbito mundial, una respuesta eficiente a las exigencias y ataques que reciben las Instituciones Estatales por parte de la Globalización. En Costa Rica, la Universidad Estatal forma parte del Servicio Público, y por esta razón, la Constitución Política impone como regla básica de la función de los Directores de las Unidades Académicas, la idoneidad comprobada. En este ensayo, se analiza el desarrollo del modelo de competencias como opción para legitimar la Universidad Pública como una Institución que cumple dicho mandato constitucional.

  8. Desafíos de las políticas publicas para enfrentar el proceso del envejecimiento de la poblacion mexicana

    Directory of Open Access Journals (Sweden)

    Moreno, M.G.

    2008-07-01

    Full Text Available The aging of the population poses an emergent problem for our country by its multiple repercussions. Between the aspects more worrying are found the sanitary situation and the gender inequity. Considering it previous, the present article has as initial purpose points out any information concerning ciphers that show the demographic aging in our country. Subsequently, the sanitary situation is raised and the conditions of health of old age; as well as some differences according to the gender. This information is used as framework of reference for the reflection concerning factors that have influenced negatively for that the conditions are not optima in this stage of the life. Finally, some strategies are proposed oriented to improve the quality of life of old age.

  9. El papel de la cuidadanía en la democracia deliberativa y su relación con la opinión publica.

    Directory of Open Access Journals (Sweden)

    Diana Carolyn Cimentes.

    2001-10-01

    Full Text Available El presente artículo busca presentar el papel que puede cumplir la ciudadanía dentro del marco de una democracia deliberativa. De tal modo la opinión pública se presenta -en el modelo deliberativo- como aquella que está centrada en el diálogo y el papel de influencia que cumpliría junto con el poder comunicativo frente al sistema-político administrativo. Es necesario por lo tanto, presentar y aclarar conceptos básicos como el de opinión pública y poder comunicativo para aclarar el papel que los ciudadanos llegarían a desempeñar, todo bajo el marco del paradigma consensual discursivo presentado en este caso bajo los lineamientos de Habermas. Teniendo en claro dicho espacio es posible pensar y aclarar temas relacionados con la legitimidad, la participación, los derechos fundamentales, el medio ambiente, la ciudad, etc. Este trabajo permite que el paradigma jurídico-político -trabajado aquí por Habermas- sea pensado como una posibilidad de reconstruir (o construir? a través de la democracia deliberativa el carácter participativo de la ciudadanía y de la opinión pública, para que de esta forma se legitime y se de soberanía al sistema, donde la sociedad civil y la opinión pública sean tenidas en cuenta por las instadas jurídico-políticas. Como conclusión del trabajo puede decirse que la falta de referentes comunes para los ciudadanos o una instada o lugar capaz de generar consenso para la fundamentación de vínculos sociales existen pero no han sido apropiadas ni asumidas.

  10. LAS TRAMPAS DE LA FALSA MODERNIZACIÓN DE LA GESTIÓN PUBLICA COSTARRICENSE: CONSIDERACIONES ALREDEDOR DE LA TEMÁTICA ENERGÉTICA 1995-2000

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    Carlos Carranza Villalobos

    2012-10-01

    Full Text Available En la ponencia se trata de vincular el contexto de la denominada modemización de la gestión pública costarricense, referido al campo energético y de telecomunicaciones. En la ponencia se enfatiza el contexto histórico en que este proceso surge, los cambios que suceden en la década de los 90, demostrando cómo una serie de acciones llevaron a la inmovilidad en relación con la institución eje en dicha materia: el Instituto Costarricense de Electricidad. En el trabajo se hace un esfuerzo para ubicar el proyecto de modernización del ICE, enfatizando los errores cometidos, así como parte del debate en relación con dicha área, de la misma manera se sitúa la respuesta de una parte importante de la sociedad civil, demostrándose que la sociedad civil consideró inoportuno tanto la forma como el fondo del tratamiento en este caso.

  11. [Valitsusliidus olevad Reformierakond ning Isamaa ja Res Publica Liit on kavandatava koolireformi suhtes eri meelt] / Mailis Reps, Tiiu Kuurme, Karin Kütt

    Index Scriptorium Estoniae

    Reps, Mailis, 1975-

    2010-01-01

    Reformierakonna ettepaneku kohta jätta omavalitsustele õiguse otsustada, kas gümnaasium ja põhikool lahutatakse või jätkatakse ühendkooliga avaldavad arvamust riigikogu liige Mailis Reps, Tallinna Ülikooli dotsent Tiiu Kuurme ja Rannu keskkooli direktor Karin Kütt

  12. Políticas publicas de juventud en America Latina: de la construcción de espacios especificos, al desarrollo de una perspectiva generacional

    Directory of Open Access Journals (Sweden)

    Ernesto Rodríguez

    2003-01-01

    Full Text Available El artículo revisa esquemáticamente las principales nociones teóricas utilizadas en la investigación comparada sobre el tema y analiza las experiencias desplegadas durante los años noventa en América Latina en el terreno de las políticas públicas de juventud, distinguiendo las explícitas (implementadas por instituciones especializadas en el tema y las implícitas (implementadas por instituciones no especializadas en el tema. En términos metodológicos, la evaluación distingue tres planos diferentes: la evaluación programática, la evaluación institucional y el uso de recursos (análisis del gasto público en juventud. Sustantivamente, el autor concluye que los impactos logrados hasta el momento han sido marginales (no se ha logrado mejorar las condiciones de vida de los jóvenes ni su participación en la sociedad y ello ha ocurrido por las limitaciones de las propias estrategias vigentes (sectoriales, universales, centralizadas, burocráticas, paternalistas, etc. Seguidamente, propone un enfoque alternativo al vigente, construido sobre la base de un análisis comparado sobre los enfoques promocionales vigentes en el trabajo con jóvenes, con mujeres y con niños. El eje de las propuestas está centrado en la necesidad de superar los clásicos esfuerzos por construir espacios específicos para la juventud (enfoque que ha contribuido a reforzar el aislamiento social de los jóvenes y de trabajar en la incorporación de un enfoque generacional al conjunto de las políticas públicas (emulando el trabajo de las mujeres centrado en la incorporación de la perspectiva de género. Sustantivamente, el autor propone invertir más y mejor en educación y salud (como claves para el desarrollo de capital humano y capital social, en la inserción laboral (como clave de la integración social de los jóvenes, en la prevención de la violencia (como clave de la convivencia pacífica y en la participación ciudadana (como clave del fortalecimiento democrático

  13. The public perception of the nuclear energy in Eastern Europe: past and present; La percepcion publica de la energia nuclear en Europa del Este: pasado y presente

    Energy Technology Data Exchange (ETDEWEB)

    Alvarez, A.; Jimenez, G.

    2010-07-01

    In Eastern Europe, people associate nuclear energy to the idea of progress, and prestige of the nuclear industry is very high. This article sets the use of nuclear technology to produce energy in a historical context that is particular to these countries. Results of interviews and surveys are analyzed in order to provide an insight on the level of acceptance among population. (Author)

  14. LIMITAÇÕES ENCONTRADAS PELOS DOCENTES DA REDE PUBLICA ESTADUAL DE COLORADO DO OESTE NO USO DA METODOLOGIA DE AULAS PRÁTICAS NO ENSINO DE BIOLOGIA

    Directory of Open Access Journals (Sweden)

    Cristiane da Silva

    2015-12-01

    Full Text Available Este trabalho é fruto de constantes observações acerca da reação dos discentes a respeito de aulas práticas realizadas no período de estagio supervisionado. Conta com um delineamento metodológico de estudo de caso onde foi aplicado um questionário de composição mista a todos os docentes de biologia das escolas estaduais de nível médio de Colorado do Oeste num total de quatro profissionais, contou também com o levantamento documental sobre o projeto do curso e os planejamentos anuais dos professores. Conclui-se ao final que a possibilidade da utilização de aulas práticas neste nível de ensino potencializa o aprendizado, tornando-o mais eficaz e integrado a realidade apesar da infraestrutura física básica ou precária utilizada para sua realização.

  15. Energy efficiency and acoustic comfort in Public Education Integrated Centers (PEICs); Eficiencia energetica e conforto acustico em CIEPs (Centros Intregrados de Educacao Publica)

    Energy Technology Data Exchange (ETDEWEB)

    Azevedo, Mariane Brito; Goncalves, Aldo Carlos de Moura [Universidade Federal do Rio de Janeiro (UFRJ), RJ (Brazil). Fac. de Arquitetura e Urbanismo. Programa de Pos-Graduacao em Arquitetura], e-mail: mariane.azevedo@ufrj.br, e-mail: aldo@msl.com.br; Salama, Jules Ghislain [Universidade Federal do Rio de Janeiro (UFRJ), RJ (Brazil). Coordenacao dos Programas de Pos-Graduacao de Engenharia (COPPE). Programa de Engenharia Mecanica], e-mail: julessslama@msl.com.br

    2008-07-01

    This paper intends to analyse the situation of the Rio de Janeiro Public Education Integrated Centers (PEICs) and presents proposals for reducing the existing acoustic problem, due to their facades and divisors, trying to harmonize the natural ventilation with control of sound pollution.

  16. Public perception on the benefits and risks of nuclear power plants. A simplified study; Um estudo simplificado da percepcao publica dos beneficios e riscos de centrais termonucleares

    Energy Technology Data Exchange (ETDEWEB)

    Ribeiro Junior, Joaquim Apparecido

    2007-07-01

    Public acceptance of the nuclear based electricity generation depends on many variables that can be affected by circumstances and interests, which although seemingly not close to the issue, can strongly influence the final outcome. Explicit or consented positions assumed by opinion makers and some segments of society are subject to episodic waves of interaction through the media and they permeate to the public in a process that is very complex to be fully understood. The modeling of such process is a very complicated undertaking, and gives no assurance of practical results concerning to what, how and who, should be given prominence in the interactions with the media and the general public. In this context, the risk communication has assumed a leading role and, as a consequence, most of the interaction with the public has been done with both defensive language and content. This study has tried a simple and practical approach to the problem, in such a way as to gather some interesting subsidies to treat this issue in a different way. The basic assumption is that in a similar way as individuals base their decision to acquire a new good or service on a 'intuitive' cost-benefit judgment, society (as a collection of individuals) also manifest their acceptance (or not) with respect to industrial installations and undertakings by comparing risks and benefits according to their perception. An exploratory survey was carried out in a few high schools, colleges and MBA courses in the state of Sao Paulo, Brazil. A first part was aimed to catch and understand the public perception of: the intrinsic value of the electric energy, the need to universalize the access to electricity, nuclear plants, the acceptance deficit of nuclear power as compared to other sources of energy, the benefits a nuclear plant can bring and who does and who does not deserves credibility to speak about nuclear plants. The second part was addressed to grasp a picture of more relevant distortions concerned to the public perception of a nuclear power plant risks. The analysis of the survey results and the utilization of a model inspired by the marketing way of value communication suggest a different approach to the communication with the public concerning to nuclear power plants. In this proposal, named Value Strategy, a matrix of risks vs. benefits is segmented in nine regions, where the central region corresponds to the current situation and the others show the possible (hypothetical) future situations after the installation of a nuclear power plant. There are three favorable regions, inductive of acceptance and three unfavorable ones, or routed to rejection. Based on the understanding of the targeted public, as partially revealed by the survey, different nuances can be emphasized in the communication to maximize its effect, without any detour to ethical behavior. Results also disclose various complementary subsidies to help the communication strategy, mainly regarded to the communication agents and to the more effective argument areas according to factors such as: sex, age ranges and educational level. (author)

  17. Bioclimatic buildings of 16 houses in Pozuelo de Alarcon (Madrid); Edificio bioclimatico de 16 viviendas de promocion publica pra jovenes en Pozuelo de Alarcon. (Madrid)

    Energy Technology Data Exchange (ETDEWEB)

    Yanez, G.; Yanez-Lopez del Amo, L.

    2004-07-01

    We present in this article a housing building for young people recently built for the Autonomous Administration of Madrid in Pozuelo de Alarcon in which have been applied some bioclimatic and energy efficiency techniques. In this communication are described the main architectural features and are exposed some of the estimated results of energy saving and reduction of Co2. (Author)

  18. 25 solar houses single-family of promotion publishes in Cantimpalos (Segovia); 25 viviendas unifamilares solares de promocion publica en Cantimpalos (Segovia)

    Energy Technology Data Exchange (ETDEWEB)

    Yanez, G.

    2008-07-01

    We present in this article a set of social houses built in Sevogia for the Autonomous Administration of Castilla y Leon in which have been applied some bio climatic and passive techniques. In this communication are described the main architectural features and are exposed the energy saving calculated and some of the results obtained through monitoring. (Author)

  19. Founder virus population related to route of virus transmission: a determinant of intrahost human immunodeficiency virus type 1 evolution?

    NARCIS (Netherlands)

    Lukashov, V. V.; Goudsmit, J.

    1997-01-01

    We and others have shown that in individual human immunodeficiency virus type 1 (HIV-1) infection, the adaptive evolution of HIV-1 is influenced by host immune competence. In this study, we tested the hypothesis that in addition to selective forces operating within the host, transmission bottlenecks

  20. A Novel Founder Mutation in MYBPC3: Phenotypic Comparison With the Most Prevalent MYBPC3 Mutation in Spain.

    Science.gov (United States)

    Sabater-Molina, María; Saura, Daniel; García-Molina Sáez, Esperanza; González-Carrillo, Josefa; Polo, Luis; Pérez-Sánchez, Inmaculada; Olmo, María Del Carmen; Oliva-Sandoval, María José; Barriales-Villa, Roberto; Carbonell, Pablo; Pascual-Figal, Domigo; Gimeno, Juan R

    2017-02-01

    Mutations in MYBPC3 are the cause of hypertrophic cardiomyopathy (HCM). Although most lead to a truncating protein, the severity of the phenotype differs. We describe the clinical phenotype of a novel MYBPC3 mutation, p.Pro108Alafs*9, present in 13 families from southern Spain and compare it with the most prevalent MYBPC3 mutation in this region (c.2308+1 G>A). We studied 107 relatives of 13 index cases diagnosed as HCM carriers of the p.Pro108Alafs*9 mutation. Pedigree analysis, clinical evaluation, and genotyping were performed. A total of 54 carriers of p.Pro108Alafs*9 were identified, of whom 39 had HCM. There were 5 cases of sudden death in the 13 families. Disease penetrance was greater as age increased and HCM patients were more frequently male and developed disease earlier than female patients. The phenotype was similar in p.Pro108Alafs*9 and in c.2308+1 G>A, but differences were found in several risk factors and in survival. There was a trend toward a higher left ventricular mass in p.Pro108Alafs*9 vs c.2308+1G>A. Cardiac magnetic resonance revealed a similar extent and pattern of fibrosis. The p.Pro108Alafs*9 mutation is associated with HCM, high penetrance, and disease onset in middle age. Copyright © 2016 Sociedad Española de Cardiología. Published by Elsevier España, S.L.U. All rights reserved.

  1. Finding the founder of Stockholm - A kinship study based on Y-chromosomal, autosomal and mitochondrial DNA

    DEFF Research Database (Denmark)

    Malmström, Helena; Vretemark, Maria; Tillmar, Andreas

    2012-01-01

    -chromosomal and autosomal SNPs and compared the results with haplogroup frequencies of modern Swedes to investigate paternal relations. Possible maternal kinship was investigated by deep FLX-sequencing of overlapping mtDNA amplicons. The authenticity of the sequences was examined using data from independent extractions......, massive clonal data, the c-statistics, and real-time quantitative data. We show that the males carry the same Y-chromosomal haplogroup and thus we cannot reject a father-son type of relation. Further, as shown by the mtDNA analyses, none of the individuals are maternally related. We conclude...

  2. A novel founder BBS1 mutation explains a unique high prevalence of Bardet-Biedl syndrome in the Faroe Islands

    DEFF Research Database (Denmark)

    Hjortshøj, T Duelund; Grønskov, K; Brøndum-Nielsen, K

    2009-01-01

    Bardet-Biedl syndrome is a multiorgan disease presenting with retinitis pigmentosa leading to blindness. The aim of the study was to investigate the genetic background of Bardet-Biedl syndrome in the Faroe Island. It was hypothesised that a common genetic background for the syndrome would be found....

  3. Jean-Martin Charcot and art: relationship of the "founder of neurology" with various aspects of art.

    Science.gov (United States)

    Bogousslavsky, Julien; Boller, François

    2013-01-01

    Jean-Martin Charcot (1825-1893), the "father of neurology" in France and much beyond, was also the man who established academic psychiatry in Paris, differentiating it from clinical alienism. In his teaching, he used artistic representations from previous centuries to illustrate the historical developments of hysteria, mainly with the help of his pupil Paul Richer. Charcot liked to draw portraits (in particular, sketches of colleagues during boring faculty meetings and students' examinations), caricatures of himself and others, church sculptures, landscapes, soldiers, etc. He also used this skill in his clinical and scientific work; he drew histological or anatomic specimens, as well as patients' features and demeanor. His most daring artistic experiments were drawing under the influence of hashish. Charcot's tastes in art were conservative; he displayed no affinity for the avant-gardes of his time, including impressionism, or for contemporary musicians, such as César Franck or Hector Berlioz. Léon Daudet, son of Charcot's former friend and famous writer Alphonse Daudet, described Charcot's home as a pseudo-gothic kitsch accumulation of heteroclite pieces of furniture and materials. However, as Henry Meige wrote a few years after his mentor's death, Charcot the artist remains "inseparable from Charcot the physician." © 2013 Elsevier B.V. All rights reserved.

  4. Herbert Aldersmith (1847-1918): Christ's Hospital medical officer and co-founder of the Medical Officers of Schools Association.

    Science.gov (United States)

    Hoskins, Trevor

    2008-02-01

    Herbert Aldersmith spent his entire working life, from the age of 23 years until his retirement at 65 years, as Resident Medical Officer to Christ's Hospital School. It was a crucial period in the school's history, from the overdue reforms of the late Victorian era to its historic move from the City of London to Sussex in 1902. He became an acknowledged authority on ringworm and also published extensively on the other great interest of his life, the British-Israel Society. He was the prime mover in founding the first-ever professional association of school doctors in 1884.

  5. Four USH2A founder mutations underlie the majority of Usher syndrome type 2 cases among non-Ashkenazi Jews.

    Science.gov (United States)

    Auslender, Noa; Bandah, Dikla; Rizel, Leah; Behar, Doron M; Shohat, Mordechai; Banin, Eyal; Allon-Shalev, Stavit; Sharony, Reuven; Sharon, Dror; Ben-Yosef, Tamar

    2008-06-01

    Type 2 Usher syndrome (USH2) is a recessively inherited disorder, characterized by the combination of early onset, moderate-to-severe, sensorineural hearing loss, and vision impairment due to retinitis pigmentosa. From 74% to 90% of USH2 cases are caused by mutations of the USH2A gene. USH2A is composed of 72 exons, encoding for usherin, an extracellular matrix protein, which plays an important role in the development and maintenance of neurosensory cells in both retina and cochlea. To date, over 70 pathogenic mutations of USH2A have been reported in individuals of various ethnicities. Many of these mutations are rare private mutations segregating in single families. The aim of the current work was to investigate the genetic basis for USH2 among Jews of various origins. We found that four USH2A mutations (c.239-240insGTAC, c.1000C>T, c.2209C>T, and c.12067-2A>G) account for 64% of mutant alleles underlying USH2 in Jewish families of non-Ashkenazi descent. Considering the very large size of the USH2A gene and the high number of mutations detected in USH2 patients worldwide, our findings have significant implications for genetic counseling and carrier screening in various Jewish populations.

  6. Frank Robert Tangherlini — the Founder of an Alternative Relativistic Kinematics (On the Occasion of His 85th Birthday

    Directory of Open Access Journals (Sweden)

    Malykin G. B.

    2009-01-01

    Full Text Available Already fifty years ago, Frank Robert Tangherlini, an American theoretical physicist, suggested an original procedure which, targeting the synchronization of clocks located in two different inertial reference frames of the space, was di erent from that Einstein had introduced. As a result of these, Tangherlini had deduced the so-called the Tangher- lini transformations, which are a sort of the transformations of the spatial coordinates and time being moved from one inertial reference frame into another one. The Tangher- lini transformations differ from the Lorentz transformations (which can be meant clas- sic ones in the theory of relativity and, in particular, suggest the velocity of light to be anisotropic in a moving inertial reference frame. The Tangherlini transformations be- ing applied provide adequate explanations to all well-known interference experiments checking of the Special Theory of Relativity.

  7. A founder effect for p47(phox)Trp193Ter chronic granulomatous disease in Kavkazi Jews

    NARCIS (Netherlands)

    de Boer, Martin; Tzur, Shay; van Leeuwen, Karin; Dencher, Paula C. D.; Skorecki, Karl; Wolach, Baruch; Gavrieli, Ronit; Nasidze, Ivane; Stoneking, Mark; Tanck, Michael W. T.; Roos, Dirk

    2015-01-01

    Chronic granulomatous disease (CGD) is a rare congenital immune deficiency caused by mutations in any of the five genes encoding NADPH oxidase subunits. One of these genes is NCF1, encoding the p47(phox) protein. A group of 39 patients, 14 of whom are of Kavkazi Jewish descent, was investigated for

  8. V.V. Davydov – the founder of significant scientific school and director of the Psychological Institute

    Directory of Open Access Journals (Sweden)

    Rubtsov V.V.

    2015-11-01

    Full Text Available The article presents the stages of biography of the famous Russian psychologist Davydov, who was a brilliant leader of a large scientific group, director of the Psychological Institute of the RAE. The content of the work of Davydov’s scientific schools is based upon the three proverbial whales that define its theoretical, methodological and didactical boundaries: the theory of content generalization and con cept formation, psychological theory of learning activity and the system of developmental teaching. The article also outlines the results of researches conducted by V.V. Davydov’s scientific group. It is demon strated that for evaluating the effectivity of learning activity, the systems of assessment of theoretical thinking and its components (such as analysis, reflection, planning, systemic characteristics of thinking were elaborated for different object matter. Also the scientific group elaborated the criteria for assessing the levels of learning activity development, as a whole as well as its separate components. The scientific school of V.V. Davydov is a living and evolving organism. The disciples and followers of Davydov conduct empirical research that bring his ideas to life. The article analyzes the philosophical, methodological and psychological foundations of Davydov’s scientific school. The content of Davydov’s debates with Vygotsky concerning the mechanisms of theo retical generalization is outlined. Davydov’s point of view is illustrated by large empirical evidence

  9. OCA1 in different ethnic groups of india is primarily due to founder mutations in the tyrosinase gene.

    NARCIS (Netherlands)

    Chaki, M.; Sengupta, M.S.; Mukhopadhyay, A.; Subba Rao, I.; Majumder, P.P.; Das, M.; Samanta, S.; Ray, K.

    2006-01-01

    Oculocutaneous albinism (OCA) is a heterogeneous group of autosomal recessive disorders characterized by an abnormally low amount of melanin in the eyes, skin and hair, and associated with common developmental abnormalities of the eye. Defects in the tyrosinase gene (TYR) cause a common type of OCA,

  10. Why Traditional Expository Teaching-Learning Approaches May Founder? An Experimental Examination of Neural Networks in Biology Learning

    Science.gov (United States)

    Lee, Jun-Ki; Kwon, Yong-Ju

    2011-01-01

    Using functional magnetic resonance imaging (fMRI), this study investigates and discusses neurological explanations for, and the educational implications of, the neural network activations involved in hypothesis-generating and hypothesis-understanding for biology education. Two sets of task paradigms about biological phenomena were designed:…

  11. Founder effect in the Horn of Africa for an insulin receptor mutation that may impair receptor recycling

    DEFF Research Database (Denmark)

    Raffan, E; Soos, M A; Rocha, N

    2011-01-01

    Genetic insulin receptoropathies are a rare cause of severe insulin resistance. We identified the Ile119Met missense mutation in the insulin receptor INSR gene, previously reported in a Yemeni kindred, in four unrelated patients with Somali ancestry. We aimed to investigate a possible genetic...

  12. Thirty-two years of Acta Neophilologica - with gratitude to its founder and editor Professor Janez Stanonik

    Directory of Open Access Journals (Sweden)

    Mirko Jurak

    2000-12-01

    Full Text Available In spring this year Professor Janez Stanonik decided to retire as the Editor of the scholarly journal Acta Neophilologica, which he founded in 1968 and edited for thirty-two years. I endeavoured to help him with the material side of the journal from the very beginning until1995; since then this task has been performed by the present Associate Editor. At the time when Janez Stanonik began publishing this journal, his main aim was to make our research work in Western European and American literature better known to scholars all over the world. However, in a few years' time the journal also became open to scholars from other countries and other fields, particularly in areas connected with Slovene literature and culture, Slovene immigrant literature, and linguistics. I believe that this approach gave the journal a new openness and that it enriched its quality, therefore I intend to follow this policy in the future too.

  13. On the number of New World founders: a population genetic portrait of the peopling of the Americas.

    Science.gov (United States)

    Hey, Jody

    2005-06-01

    The founding of New World populations by Asian peoples is the focus of considerable archaeological and genetic research, and there persist important questions on when and how these events occurred. Genetic data offer great potential for the study of human population history, but there are significant challenges in discerning distinct demographic processes. A new method for the study of diverging populations was applied to questions on the founding and history of Amerind-speaking Native American populations. The model permits estimation of founding population sizes, changes in population size, time of population formation, and gene flow. Analyses of data from nine loci are consistent with the general portrait that has emerged from archaeological and other kinds of evidence. The estimated effective size of the founding population for the New World is fewer than 80 individuals, approximately 1% of the effective size of the estimated ancestral Asian population. By adding a splitting parameter to population divergence models it becomes possible to develop detailed portraits of human demographic history. Analyses of Asian and New World data support a model of a recent founding of the New World by a population of quite small effective size.

  14. Kolm ministrit valgustasid Kagu-Eesti omavalitsusjuhte / Mari-Anne Leht

    Index Scriptorium Estoniae

    Leht, Mari-Anne, 1950-

    2003-01-01

    Valgamaal Taageperas räägiti Kagu-Eesti omavalitsusjuhtidele haridusest, haridusreformist ja rahast. Kohal olid ka haridus- ja teadusminister Toivo Maimets, siseminister Jaan Õunapuu ja majandusminister Meelis Atonen. Kommenteerivad Rein Randver, Pille Tali, Sirje Tobreluts jt. Vt. samas: Hannes Võrno kaebas rasket elu

  15. Praostkondade uudised : Viljandi. Põltsamaa

    Index Scriptorium Estoniae

    2006-01-01

    10.-11. aug. Helme kogudust külastanud norra koori Lillebergkvartetten kontserdist Taageperas Helme valla hooldekodus. 15. aug. Helme Maarja koguduses peetud maarjapäeval saatis koguduse laule Tõrva puhkpilliorkester. Põltsamaa kogudus külastas 14.-18. aug. sõpruskogudusi Soomes, andes barokkmuusika kontserdi

  16. Sadolini värvid / Piret Veigel

    Index Scriptorium Estoniae

    Veigel, Piret, 1961-

    2004-01-01

    11. III korraldas Akzo Nobel Taagepera lossis arhitektide õppepäeva. Esinesid Leonhard Lapin ja Rootsi esteetikakeskuse juht Per Nimer, kes tutvustas esteetikakeskuse värvusspetsialistide poolt 2003. a. väljatöötatud trendikaid värvikombinatsioone

  17. Koalitsionnoje rasputje / Josef Kats

    Index Scriptorium Estoniae

    Kats, Josef, 1977-

    2005-01-01

    Reformierakond ja Res Publica hakkasid otsima võimalikke koalitsioonipartnereid. Res Publica peasekretäri Ott Lumi arvates peaksid uue valitsuse moodustama justiitsministrile umbusaldust avaldanud erakonnad

  18. I eto vsjo o njom... / Valentin Zvegintsev

    Index Scriptorium Estoniae

    Zvegintsev, Valentin

    2005-01-01

    Res Publica nõuniku Nikolai Stelmachi sõnul ei saa Res Publica valimisreklaami Tallinnas kuidagi plagiaadiks nimetada, tema hinnangul on Reformierakonna ja Res Publica valimisplakatid Tallinnas sisult erinevad, kuid Reformierakond võttis üle Res Publica idee lastevanemate toetamise kohta. Reformierakonna liikme Tatjana Muravjova arvamus

  19. Mõisa peale kulub miljoneid kroone / Peeter Raidla

    Index Scriptorium Estoniae

    Raidla, Peeter, 1955-

    2005-01-01

    Ärimehed renoveerivad Eestimaa mõisaid. Lähemalt Taagepera lossist, Atla mõisast, Liigvalla mõisast, Esna mõisast, Ingliste mõisast, Nabala mõisast, Ontika mõisast, Kolu mõisast, Hõreda mõisast, Vihterpalu mõisast, Kalvi mõisast, Rägavere mõisast. Loetletud mõisate praegused omanikud

  20. Uudised : Tüüri esiettekanne Frankfurdis. Corelli Musicult "Jõulud mõisas"

    Index Scriptorium Estoniae

    2006-01-01

    22., 23. ja 24. nov. Frankfurdi Alte Operis esiettekandele tulevast Erkki-Sven Tüüri uuest "Klaverikontserdist". Eesti-Tšiili trio Raivo Tafenau - Meelis Vind - Ricardo Padilla kontsertidest sarja "Mõisaromantika" raames 25. nov. Taagepera lossis Valgamaal, 26. nov. Tõstamaa mõisas Pärnumaal ja 16. dets. Vihterpalu mõisas Harjumaal. Hans Neuenfelsi lavastatud Mozarti ooperist "Idemeneo" Deutsche Operis Berliinis. Inglise ansambli Procol Harumi hiti "A Whiter Shade of Pale" autoriõigustest