Kes tegelikult lõid Res Publica? / Valeri Kalabugin

Index Scriptorium Estoniae

Kalabugin, Valeri

2005-01-01

Enne erakonnaks kuulutamist oli Res Publica Eesti iseseisvust ja demokraatiat taotlev ühendus, kuhu on kuulunud mitmed poliitika- ning ühiskonnategelased. Vt. samas: Ühendus Res Publica avaldus. Küsimustele vastavad Res Publica avalike suhete juht Riina Vändre, Riigikogu liige Mart Nutt, ajakirjanik Toomas Kümmel

Do (Female) Founders Influence (Female) Joiners to Become Founders too?

DEFF Research Database (Denmark)

Rocha, Vera; Van Praag, Mirjam

-founder (gender) homophily affects the likelihood of female and male joiners to become founders themselves. We find a relatively large and robust positive effect among female joiners that can be attributed to the role modeling function of female founders. Female entrepreneurs hiring personnel may thus have...

Mida ootame Res Publica poliitikutelt? / Andreas Kaju

Index Scriptorium Estoniae

Kaju, Andreas

2003-01-01

Res Publica Juventus on piirkondadele saadetud küsitlustega otsinud vastuseid mitmetele probleemidele. Eesmärk Res Publica poliitilise käitumise raamide määramine. Tabel: Juventuse küsimused piirkondadele

Rahvaliit likvideerib Res Publica veeuputust / Janno Reiljan

Index Scriptorium Estoniae

Reiljan, Janno, 1951-2018

2005-01-01

Ilmunud ka: Molodjozh Estonii 1. august lk. 5. Selgitused Res Publica esimehe Taavi Veskimägi artiklile 25. juuli Postimehes "Pärast meid tulgu või veeuputus". Res Publica ja Rahvaliidu poliitika võrdlus

Res Publica esitas avalduse kaposse / Virkko Lepassalu

Index Scriptorium Estoniae

Lepassalu, Virkko, 1971-

2003-01-01

Kaposse jõudis Res Publica avaldus, milles palutakse uurida erakonda seadusvastaselt anonüümselt sponsoreerima kutsuva kirja tagamaid. Vt. ka Äripäev 19. veebruar lk. 6 "Kapo ei alustanud Res Publica avalduse peale kriminaalmenetlust"

Res Publica soolo rikkus tavasid / Kai Kalamees

Index Scriptorium Estoniae

Kalamees, Kai

2005-01-01

Riigikogu aseesimeheks valiti Res Publica liige Taavi Veskimägi, nüüd on Riigikogu juhatuses kaks ühe partei liiget. Riigikogu aseesimeheks tagasi valitud Toomas Vareki hinnangul näitab see samm nii Res Publica kogenematust kui ka Eesti poliitilise kultuuri kehva taset

Evaluation of the ProPublica Surgeon Scorecard "Adjusted Complication Rate" Measure Specifications.

Science.gov (United States)

Ban, Kristen A; Cohen, Mark E; Ko, Clifford Y; Friedberg, Mark W; Stulberg, Jonah J; Zhou, Lynn; Hall, Bruce L; Hoyt, David B; Bilimoria, Karl Y

2016-10-01

The ProPublica Surgeon Scorecard is the first nationwide, multispecialty public reporting of individual surgeon outcomes. However, ProPublica's use of a previously undescribed outcome measure (composite of in-hospital mortality or 30-day related readmission) and inclusion of only inpatients have been questioned. Our objectives were to (1) determine the proportion of cases excluded by ProPublica's specifications, (2) assess the proportion of inpatient complications excluded from ProPublica's measure, and (3) examine the validity of ProPublica's outcome measure by comparing performance on the measure to well-established postoperative outcome measures. Using ACS-NSQIP data (2012-2014) for 8 ProPublica procedures and for All Operations, the proportion of cases meeting all ProPublica inclusion criteria was determined. We assessed the proportion of complications occurring inpatient, and thus not considered by ProPublica's measure. Finally, we compared risk-adjusted performance based on ProPublica's measure specifications to established ACS-NSQIP outcome measure performance (eg, death/serious morbidity, mortality). ProPublica's inclusion criteria resulted in elimination of 82% of all operations from assessment (range: 42% for total knee arthroplasty to 96% for laparoscopic cholecystectomy). For all ProPublica operations combined, 84% of complications occur during inpatient hospitalization (range: 61% for TURP to 88% for total hip arthroplasty), and are thus missed by the ProPublica measure. Hospital-level performance on the ProPublica measure correlated weakly with established complication measures, but correlated strongly with readmission (R = 0.834, P Scorecard is questionable.

Res Publica meelitab valla- ja linnajuhte / Henrik Roonemaa

Index Scriptorium Estoniae

Roonemaa, Henrik

2001-01-01

Valitsusliidu regionaalpoliitikas pettunud 30 omavalitsusjuhti on astunud ühenduse Res Publica liikmeks, lootes selle põhjal tekkiva partei abil kohaliku ja riigivõimu taas omavahel suhtlema panna. Vt. samas Res Publica liikmetest omavalitsusjuhid

Res Publica pakub sponsoritele anonüümsust / Virkko Lepassalu

Index Scriptorium Estoniae

Lepassalu, Virkko, 1971-

2003-01-01

Mõnede tõenäoliselt Res Publica lähedaste ettevõtjate seas levib erakonna nimel rahapalumiskiri, mis lubab sponsorile anonüümsust. Vt. samas: Telefonikõne ettevõtja ja Res Publica aseesimehe Ken-Marti Vaheri vahel ; Teisedki on saanud rahaallikaid varjates ; Res Publica on loobunud reklaamibroneeringutest

Res Publica lükkas tagasi Isamaaliidu ühinemisettepaneku / Mirko Ojakivi

Index Scriptorium Estoniae

Ojakivi, Mirko

2005-01-01

Kuigi Res Publica juhid lükkasid tagasi idee ühineda Isamaaliiduga, on Res Publica valmis koostööks nii Isamaaliidu kui ka kõigi teiste erakondadega. Res Publica parlamendifraktsiooni esimehe Marko Pomerantsi arvamus

Res Publicas käärib mäss / Hants Hint

Index Scriptorium Estoniae

Hint, Hants

2002-01-01

Res Publica eestseisuse liige ja Ida-Viru piirkonna esimees Hants Hint vastab küsimustele Res Publica ja Keskerakonna võimuliidu moodustamisega tekkinud skandaali, Res Publica esimehe Juhan Partsiga kohtumise kohta. Vt. samas: "Korbi toetajaid ootab hukkamõist"

Res Publica viskab Oleg Rebase välja

Index Scriptorium Estoniae

2006-01-01

Res Publica Tallinna piirkonna juhatus leidis, et Oleg Rebane läks Keskerakonna provokatsiooniga kaasa minnes vastuollu Res Publica põhimõtetega. Tallinna linnapea Jüri Ratase suhtes algatatud umbusaldushääletuse põhjustest. Sven Sester vastab küsimusele, mis seotud Oleg Rebase ja Tõnis Bittmani juhtumiga

Parts ei soovi Res Publica esimehe ametit / Tuuli Koch

Index Scriptorium Estoniae

Koch, Tuuli

2005-01-01

Kõige tõenäolisem kandidaat Res Publica juhi kohale on Taavi Veskimägi, aseesimeesteks kandideerivad Marko Mihkelson ja Henn Pärn. Res Publica fraktsiooni koosolekul leidis Mihhail Lotman, et erakond võiks olla feminiinsem

Res Publica kärbiks võimuorganite koosseise / Argo Ideon

Index Scriptorium Estoniae

Ideon, Argo, 1966-

2002-01-01

Res Publica taotleb Riigikogu kärpimist 61 liikmeni, lubab kahandada kohalike volikogude koosseise, Tallinna abilinnapeade arvu ja kaotada portfellita ministrite kohad. Vt. samas: Res Publica valimisnimekiri Tallinnas

Res Publica ladvikus hõõgub võimutüli / Tuuli Koch

Index Scriptorium Estoniae

Koch, Tuuli

2006-01-01

22. aprillil kogunenud Res Publica volikogu toetas 60 poolthäälega ühe vastu Res Publica ja Isamaaliidu ühinemist. Tõnis Palts teatas volikogul esinedes, et Taavi Veskimägi ei sobi Res Publica poolseks läbirääkimiste juhiks

Res Publica andis kolmele poliitikule fiktiivse elukoha / Kärt Karpa

Index Scriptorium Estoniae

Karpa, Kärt, 1973-

2002-01-01

Väidetavalt lasi Res Publica enne kohalikke valimisi ühte Pirita eramajja sisse registreerida Jaanus Rahumäe ja veel kaks Res Publica liiget, et nad saaksid kandideerida Tallinna volikogusse ja Pirita halduskogusse

Res Publica kõrvaldas mässaja / Kristjan Roos

Index Scriptorium Estoniae

Roos, Kristjan, 1978-

2005-01-01

Tallinna linnavolikogu Res Publica fraktsiooni juhi kohalt, Res Publica Tallinna piirkonna juhatusest ja erakonna eestseisusest end taandanud Toomas Tautsi sõnul esitati talle erakonna eestseisuses mitmeid süüdistusi, mis kokkuvõtvalt olid etteheited tema vastuseisule võimalikule koalitsioonile Keskerakonnaga. Lisa: Abilinnapeadeks saavad Promm, Reivik ja Pevkur

Alfabetización informacional y biblioteca publica

OpenAIRE

José Antonio Gómez Hernández; Cristóbal Pasadas-Urena

2007-01-01

Introducción. El objetivo del trabajo es hacer una revisión de la alfabetización informacional en las bibliotecas publicas. Se describe la alfabetización informacional como una competencia básica de las personas para saber encontrar y usar la información adecuada a sus necesidades, independientemente del lugar, soporte o medio utilizado para su transmisión. Se explica las tendencias internacionales y locales para la incorporación de este servicio en las bibliotecas publicas, y se justifica la...

Res Publica Euroopas / Eiki Berg, Marko Mihkelson ; interv. Lauri Lugna

Index Scriptorium Estoniae

Berg, Eiki, 1970-

2003-01-01

Res Publica välispoliitika eksperdid Eiki Berg ja Marko Mihkelson vastavad küsimustele, mis käsitlevad Res Publica saamist Euroopa Rahvapartei (ERP) liikmeks, koostööd ERP-ga, EL-i põhiseaduslikku lepet

Res Publica aukohus heidab juhtidele ette eetikavääratust / Toomas Mattson

Index Scriptorium Estoniae

Mattson, Toomas, 1970-

2002-01-01

Ilmunud ka: Põhjarannik ; Severnoje Poberezhje 22. november lk. 3;4. Res Publica aukohus arvab, et Res Publica juhid on rikkunud erakonna põhikirja, sisekorda ja eetikakoodeksit Kohtla-Järve juhtumi lahendamisel. Kohtla-Järvel sai linnapeaks riisumiskahtlusega uurimise all olev Valeri Korb tänu Keskerakonna ja Res Publica koalitsioonileppele. Kommenteerib Juhan Kivirähk

Res Publica mängis topeltmängu / Risto Berendson

Index Scriptorium Estoniae

Berendson, Risto, 1975-

2005-01-01

Res Publica jätkab koostööd Tallinna linnavalitsuses Reformierakonnaga. Tallinna linnapea Tõnis Paltsi sõnul oli paralleelsete läbirääkimiste pidamine Keskerakonna ja Reformierakonnaga Res Publica Tallinna piirkonna juhatuse valitud taktika. Kommenteerib Jaanus Piirsalu

Res Publica lihtliikmed tõrjuvad Veskimäge / Tuuli Koch

Index Scriptorium Estoniae

Koch, Tuuli

2006-01-01

Ilmunud ka: Pärnu Postimees 17. okt. lk. 6. Isamaa ja Res Publica liidu peaministrikandidaadiks sai Mart Laar, kuid pinged erakondade sees kestavad edasi. Res Publica opositsioon toetab isamaaliitlast Mart Laari ja on Taavi Veskimäe vastu. Lisa: Otsitakse peaministrit

Res Publica Ida-Viru piirkond valis uue juhatuse / Erik Gamzejev

Index Scriptorium Estoniae

Gamzejev, Erik, 1967-

2002-01-01

Ilmunud ka: Severnoje Poberezhje 4. dets. lk. 1. Res Publica Ida-Viru piirkonna üldkogul valiti uus juhatus, Vladimir Sarantsevi sõnul oli koosolek enamiku Kohtla-Järve osakonna liikmete arvates õigustühine. Res Publica peasekretäri Tõnis Konsi kommentaare

Presidendilossis pidutses ka üks Res Publica liige / Kadri Jakobson

Index Scriptorium Estoniae

Jakobson, Kadri, 1970-

2006-01-01

SL Õhtulehele presidendilossis toimunud noortepidudest rääkinud neiu on Res Publica liige, kuid tema sõnul pole tema parteiline kuuluvus pidudega seotud. Arvamust avaldavad Res Publica juhatuse liige Andreas Kaju, erakonna esimees Taavi Veskimägi, ERL-i pressiesindaja Agu Uudelepp jt.

Res Publica asus Reformierakonda Tallinna võimuliidust tõrjuma / Mirko Ojakivi

Index Scriptorium Estoniae

Ojakivi, Mirko

2005-01-01

Res Publica Tallinna piirkonna juhatuse liikme Siim Roode sõnul teeb Res Publica Keskerakonna Tallinna piirkonna juhatusele ettepaneku koalitsiooniläbirääkimiste alustamiseks. Lisa: Paltsu ettekäändeks Unicom

Res Publica : umbusaldamine võib lõpetada senise koalitsiooni / Villy Paimets

Index Scriptorium Estoniae

Paimets, Villy, 1972-

2005-01-01

Res Publica erakorraline volikogu avaldas toetust justiitsministrile ja andis peaministrile volitused lõpetada justiitsministri umbusaldamise korral senine koalitsioon ning alustada läbirääkimisi Isamaaliiduga. Lisa: Res Publica toetab Vaherit

Res Publica seisab vastu homse arvel elamisele / Siim Männik

Index Scriptorium Estoniae

Männik, Siim

2005-01-01

Ilmunud ka: Vabariik (venek.) 30. august lk. 1. Res Publica koostab praegu kohalikeks valimisteks nimekirju. Erakond ei plaani korraldada mitte ühte üleriigilist valimiskampaaniat, vaid 120 kohalikku kampaaniat, peale selle on kavas üleriigiline n.-ö. foonikampaania. Lisa: Miks valida Res Publica? Vt. samas: Sisevalimised 1.-3. septembrini

Alfabetización informacional y biblioteca publica

Directory of Open Access Journals (Sweden)

José Antonio Gómez Hernández

2007-01-01

Full Text Available Introducción. El objetivo del trabajo es hacer una revisión de la alfabetización informacional en las bibliotecas publicas. Se describe la alfabetización informacional como una competencia básica de las personas para saber encontrar y usar la información adecuada a sus necesidades, independientemente del lugar, soporte o medio utilizado para su transmisión. Se explica las tendencias internacionales y locales para la incorporación de este servicio en las bibliotecas publicas, y se justifica la importancia de ello por su conexión con el aprendizaje durante toda la vida, que hace de las bibliotecas un recurso fundamental para la educación no formal e informal de los ciudadanos. Método. Se analiza y describe las publicaciones, modelos conceptuales, proyectos, documentos normativos de asociaciones profesionales y los contenidos de los encuentros científicos y profesionales sobre alfabetización informacional y biblioteca publica. Análisis. Se hace un estudio comparativo de las distintas teorías y proyectos, y se hace una valoración critica confrontando éstas con su aplicación práctica en las bibliotecas. Resultados. A partir del análisis se exponen las tendencias en alfabetización informacional y se proponen tareas básicas para una agenda de desarrollo en las bibliotecas publicas de este servicio. Conclusión. Se propone una agenda comun de todas las bibliotecas, instituciones y profesiones involucradas en la adquisición por individuos y comunidades de las competencias básicas englobadas bajo el concepto de alfabetización continua.

Juhan Parts soovib Res Publica tagasi tippu viia / Toomas Sildam

Index Scriptorium Estoniae

Sildam, Toomas, 1961-

2004-01-01

Res Publica esimees peaminister Juhan Parts plaanib minna oma erakonnaga kohalikele valimistele ning uurib võimalusi paremerakondade ühinemiseks. Rakveres toimunud erakonna üldkogust. Lisad: Peaministri neli rasket hetke; Res Publica ministrid said parteilt toetuse. Vt. samas: Reformierakond kiitis Res Publicat hea koostöö eest; Parts: 191 vastuhäält on hea tulemus

Sisetülides Res Publica heitis liidu Keskerakonnaga kõrvale / Urmas Seaver

Index Scriptorium Estoniae

Seaver, Urmas, 1973-

2005-01-01

Res Publica juhatus otsustas toetada senise koalitsiooni jätkamist Tallinnas. Res Publica ja Reformierakonna täiendatud koalitsioonileppest. Reformierakonna Tallinna piirkonna juhi Keit Pentuse hinnang võimutülile. Lisa: Võimuleppe lisa

Res Publica hakkab kaaluma Kohtla-Järve võimuliidust lahkumist / Erik Gamzejev

Index Scriptorium Estoniae

Gamzejev, Erik, 1967-

2002-01-01

Ilmunud ka: Severnoje Poberezhje 19. nov. lk. 1. Res Publica eestseisuse ettepanek Kohtla-Järve osakonnale lahkuda koalitsioonist. Osakonna juhatuse otsus esitada Hants Hint volikogu esimehe kandidaadiks. Res Publica liikmete käitumise arutelu aukohtus

New Firm Performance and the Replacement of Founders

DEFF Research Database (Denmark)

Chen, Jing; Thompson, Peter

We construct a simple model of founder turnover in which there may be mismatches between the quality of a startup and the ability of the founder. When high-ability founders establish poor-quality businesses, they either choose to close the business or hire a less able CEO. In contrast, low......-ability founders with highquality businesses hire a more able CEO. We derive implications of the model for the relationship between firm performance and founder turnover. These predictions are tested using a large sample of Danish startups....

Res Publica tähistab sünnipäeva konverentsiga / Lauri Tankler

Index Scriptorium Estoniae

Tankler, Lauri

2003-01-01

Ilmunud ka: Võta Võim : na russkom jazõke 3. dets. lk. 3. Res Publica saab 2-aastaseks, mille puhul korraldatakse konverents "Riik ja Res Publica". Vt. samas: Selle aasta veebruaris said kuldmärgid

Res Publica presidendikandidaatide nimed selguvad neljapäevaks / Rauno Veri, Urmo Kübar

Index Scriptorium Estoniae

Veri, Rauno, 1978-

2006-01-01

Res Publica, Isamaaliit, Reformierakond, SDE ja Keskerakond otsivad ühist presidendikandidaati, ainsa parlamendierakonnana ei osale läbirääkimistel Rahvaliit. Reformierakonna, SDE presidendikandidaatidest; Res Publica naiskogu ja Väärikate Kogu ühisavaldusest

Fides Publica in Ancient Rome and its Reception by Grotius and Locke

NARCIS (Netherlands)

de Wilde, M.

2011-01-01

The article analyzes the Roman notion of des publica and its reception by Grotius and Locke. The Romans considered des publica a general standard of behavior for all those invested with state power. It was regarded as a legal norm with moral connotations, which applied especially, though not

Founder Mutations in Xeroderma Pigmentosum

Science.gov (United States)

Tamura, Deborah; DiGiovanna, John J.; Kraemer, Kenneth H.

2012-01-01

In this issue, Soufir et al. report a founder mutation in the XPC DNA repair gene in 74% of families with xeroderma pigmentosum (XP) in the Maghreb region (Algeria, Morocco, and Tunisia) of northern Africa. These patients have a high frequency of skin cancer. The presence of this founder mutation provides an opportunity for genetic counseling and early diagnosis of XP. PMID:20463673

Ühendpartei Res Publica tiib oli häältekogumisel Isamaast pisut edukam

Index Scriptorium Estoniae

2007-01-01

Ühenderakonna Res Publica tiiva kandidaadid said Riigikogu valimistel umbes tuhat häält rohkem kui Isamaaliidu tiiva kandidaadid, samas oli IRL-i valimisnimekirjas Res Publica tiiva kandidaate ka mõne inimese võrra rohkem. Isamaaliidu edukaimad hääletoojad

The reality and importance of founder speciation in evolution.

Science.gov (United States)

Templeton, Alan R

2008-05-01

A founder event occurs when a new population is established from a small number of individuals drawn from a large ancestral population. Mayr proposed that genetic drift in an isolated founder population could alter the selective forces in an epistatic system, an observation supported by recent studies. Carson argued that a period of relaxed selection could occur when a founder population is in an open ecological niche, allowing rapid population growth after the founder event. Selectable genetic variation can actually increase during this founder-flush phase due to recombination, enhanced survival of advantageous mutations, and the conversion of non-additive genetic variance into additive variance in an epistatic system, another empirically confirmed prediction. Templeton combined the theories of Mayr and Carson with population genetic models to predict the conditions under which founder events can contribute to speciation, and these predictions are strongly confirmed by the empirical literature. Much of the criticism of founder speciation is based upon equating founder speciation to an adaptive peak shift opposed by selection. However, Mayr, Carson and Templeton all modeled a positive interaction of selection and drift, and Templeton showed that founder speciation is incompatible with peak-shift conditions. Although rare, founder speciation can have a disproportionate importance in adaptive innovation and radiation, and examples are given to show that "rare" does not mean "unimportant" in evolution. Founder speciation also interacts with other speciation mechanisms such that a speciation event is not a one-dimensional process due to either selection alone or drift alone. (c) 2008 Wiley Periodicals, Inc.

New Firm Performance and the Replacement of Founder-CEOs

DEFF Research Database (Denmark)

Chen, Jing; Thompson, Peter

2015-01-01

We study the causes and consequences of the replacement of founder-CEOs in a sample of 4,172 Danish start-ups. We propose that founder-CEO replacement is driven in part by mismatches between business quality and founder ability. Our framework suggests that replacements are more likely among...... the worst- and best-performing firms, with low (high)-ability founders replaced by manager with higher (lower) ability. Replacement is not unambiguously associated with better subsequent performance. Firms that replaced the founder were much more likely to fail, but the surviving firms among them grew...

Res Publica toetus pole aastaga üle viie protsendi tõusnud / Tuuli Koch

Index Scriptorium Estoniae

Koch, Tuuli

2006-01-01

Emori jaanuarikuu küsitluse põhjal on 22 protsendiga suurim toetajaskond Keskerakonnal, Res Publica reiting on aasta aega püsinud viie ja kolme toetusprotsendi vahel. Vt. samas: Taavi Veskimägi. 2 küsimust. Diagrammid: Res Publica valiks riigikogusse tagasi vaid kolm protsenti valijaist; Toetus Res Publicale

Isamaa ja Res Publica Liidu plaan / Juhan Parts

Index Scriptorium Estoniae

Parts, Juhan, 1966-

2008-01-01

Ilmunud ka: Eesti Eest = Za Estoniju : Izdanije objedinenija "Sojuz Otetshestva i Res Publica" 15. mai 2008, lk. 4-5. Eesti majanduse uutest ülesannetest. Kommenteerib: Mart Laar. Vt. samas: IRL-i ettepanekud koalitsioonileppe täienduseks

Publicação Científica

Directory of Open Access Journals (Sweden)

Getulio Teixeira Batista

2006-12-01

Full Text Available O gerenciamento da editoração da revista científica integrada em um sistema digital que permite o monitoramento de um artigo desde a submissão até a publicação como o Sistema de Editoração Eletrônica de Revistas (SEER, Soares et al., 2004, a partir de qualquer ponto de acesso à Internet, representa um grande avanço no processo de editoração não só pela economia de papel e correio, mas principalmente por agilizar a comunicação do editor com os autores e revisores. É fundamental que o editor fique extremamente atento no fomento dessa interação. A motivação para publicações é muito variável e afeta o processo de publicação nas diferentes fases. Muitos estudantes submetem trabalhos para cumprir exigências de cursos e ao se depararem com o processo de revisão acabam desistindo porque já cumpriram a exigência e não querem investir o tempo necessário exigido pela revisão de seu artigo. Cabe ao editor o papel de incentivador da busca da qualidade. É fundamental que o editor não seja um mero repassador das observações dos avaliadores, mas que as interprete e interaja com os autores para que elas sejam implementadas adequadamente para melhoria da qualidade do artigo. Ao encerrar o primeiro volume, a editoração da Ambi-Água tem a satisfação de manifestar que a interação com os autores e avaliadores foi uma constante, o que resultou num tempo mínimo de processamento da editoração.

Pettumus Res Publicas algas kirikus antud vandest / Margus Tsahkna

Index Scriptorium Estoniae

Tsahkna, Margus, 1977-

2005-01-01

Autori sõnul on Res Publica petnud inimeste põhiväärtustele tuginevaid ootusi, Eesti riik kaugeneb kodanikust ja tema elulistest huvidest. Isamaaliit paneb ette asuda tegelike probleemide lahendamisele ning kutsub erakondi üles kaitsma rahvuslikke huve

Res Publica soovib riigikogulaste kuluhüvitiste korra muutmist / Siim-Valmar Kiisler ; interv. Kalle Muuli

Index Scriptorium Estoniae

Kiisler, Siim, 1965-

2003-01-01

Res Publica saadikud teevad Riigikogu juhatusele ettepaneku muuta kuluhüvitiste korda, teatas intervjuus Res Publica saadikurühma esimees Siim-Valmar Kiisler. Kommenteerivad: Jaanus Männik, Toomas Varek. Vt. samas: Riigikogu liikmete vastuseid küsimustele tööga seotud kulude kohta: Robert Lepikson, Reet Roos, Janno Reiljan

Res Publica nõuab Leinatammelt 44 600 krooni / Kadri Jakobson

Index Scriptorium Estoniae

Jakobson, Kadri, 1970-

2005-01-01

Res Publica nõuab Reformierakonda üle läinud Tarmo Leinatammelt maksmata jäänud liikmemaksu, fraktsioon kutsub teda üles loobuma kohast Riigikogus. Erakonna pressiesindaja Riina Vändre selgitus

Res Publica murrab läbi / Urmo Kübar

Index Scriptorium Estoniae

Kübar, Urmo, 1978-

2004-01-01

Ilmunud ka: Võta Võim : na russkom jazõke, 28. apr. 2004, lk. 1. 18. aprillil 2004 Tallinnas toimunud Res Publica valimiskonverentsist, kus kinnitati programm ja kandidaadid Euroopa Parlamendi valimisteks. Esinesid Urmas Reinsalu ja Juhan Parts. Vt. samas: Kust tuli 'Murrame läbi'?

A European Res publica

Directory of Open Access Journals (Sweden)

Ola Zetterquist

2011-05-01

Full Text Available The article analyses the fundamental constitutional enigma of the European Union (EU, namely whether the EU can be considered as a (from its Member States separate and independent constitutional legal order. The EU is often referred to as a legal order sui generis, i.e. of a unique character that defies traditional definitions. More specifically, the notion of an independent and separate EU is at odds with the idea of the sovereign state. The notion of the EU as a legal order sui generis is too much influenced by the models of the sovereign state and sovereignty (in the vein of Thomas Hobbes. The key component in the Hobbesian idea of sovereignty is freedom as non-interference. A sovereign state is consequently a state that is free from, i.e. not interfered with by, external actors like, for example, the EU. Put differently, either the EU is sovereign or the Member States are sovereign. By shifting the perspective to a neo-Roman republican understanding of freedom as non-domination the constitutional picture of the EU will become more nuanced. Res publica is best understood as what citizens hold in common and above their narrow self-interest. According to a republican notion of the constitution the purpose of the law is to eliminate the possibility of arbitrary domination. For that reason, not all interference is to be considered as a restriction of freedom but only those restrictions that cannot be justified according to the res publica. Viewed through the republican prism it can be argued that the EU represents an important advancement in securing freedom as non-domination without implying that the EU must become a state. The fundamental enigma can thus be rephrased as a clash between two diverging concepts of freedom. Whereas the EU will always be at odds with the idea of sovereignty (however framed it will be much easier to reconcile with the republican ideal. DOWNLOAD THIS PAPER FROM SSRN: http://ssrn.com/abstract=1837332

Reinsalu : Res Publica lisab kiirust / Urmas Reinsalu ; interv. Lauri Tankler

Index Scriptorium Estoniae

Reinsalu, Urmas, 1975-

2004-01-01

Ilmunud ka: Võta Võim : na russkom jazõke, 28. apr. 2004, lk. 4. Res Publica esikandidaat Urmas Reinsalu erakonna valimiskampaania eesmärkidest, võimalustest nende eesmärkide saavutamiseks ja erakonna valimisprogrammi ning kandidaatide eelistest konkurentide ees

Corporate Social Responsibility in Large Family and Founder Firms

NARCIS (Netherlands)

J.H. Block (Jörn); M. Wagner (Marcus)

2010-01-01

textabstractBased on arguments about long-term orientation and corporate reputation, we argue that family and founder firms differ from other firms with regard to corporate social responsibility. Using Bayesian analysis, we then show that family and founder ownership are associated with a lower

Founder Family Influence and Foreign Exchange Risk Management

DEFF Research Database (Denmark)

Aabo, Tom; Kuhn, Jochen; Zanotti, Giovanni

2011-01-01

Purpose    The purpose of this study is to explore the influence of founder families in medium-sized, manufacturing firms and to investigate the impact of such influence on risk management - more specifically foreign exchange hedging and speculation. Design/methodology/approach This empirical study...... in the management team, are members of the board of directors, and/or are shareholders of the firm. We find no difference between such founder family firms and other firms in terms of the use / non-use decision related to foreign exchange derivatives but a marked difference in terms of the extent decision. Thus...... in medium-sized firms (as opposed to large, listed firms in most other studies) and adds to the sparse literature on the impact of founder family influence on risk management.  ...

Recurrent and founder mutations in the PMS2 gene.

Science.gov (United States)

Tomsic, J; Senter, L; Liyanarachchi, S; Clendenning, M; Vaughn, C P; Jenkins, M A; Hopper, J L; Young, J; Samowitz, W; de la Chapelle, A

2013-03-01

Germline mutations in PMS2 are associated with Lynch syndrome (LS), the most common known cause of hereditary colorectal cancer. Mutation detection in PMS2 has been difficult due to the presence of several pseudogenes, but a custom-designed long-range PCR strategy now allows adequate mutation detection. Many mutations are unique. However, some mutations are observed repeatedly across individuals not known to be related due to the mutation being either recurrent, arising multiple times de novo at hot spots for mutations, or of founder origin, having occurred once in an ancestor. Previously, we observed 36 distinct mutations in a sample of 61 independently ascertained Caucasian probands of mixed European background with PMS2 mutations. Eleven of these mutations were detected in more than one individual not known to be related and of these, six were detected more than twice. These six mutations accounted for 31 (51%) ostensibly unrelated probands. Here, we performed genotyping and haplotype analysis in four mutations observed in multiple probands and found two (c.137G>T and exon 10 deletion) to be founder mutations and one (c.903G>T) a probable founder. One (c.1A>G) could not be evaluated for founder mutation status. We discuss possible explanations for the frequent occurrence of founder mutations in PMS2. © 2012 John Wiley & Sons A/S.

Res Publica üldkogu hääletab poliitilisi resolutsioone / Lauri Tankler

Index Scriptorium Estoniae

Tankler, Lauri

2004-01-01

Res Publica üldkogul hääletusele pandavate resolutsioonide eesmärgiks on teavitada avalikkust erakonna seisukohtadest. Olulisemad resolutsioonid on ette valmistatud ideoloogia, majanduse, hariduse ja sotsiaalpoliitika valdkonnas

Desafios das publicações feministas

Directory of Open Access Journals (Sweden)

Carmen Silva

2013-11-01

Full Text Available http://dx.doi.org/10.1590/S0104-026X2013000200014 Por ocasião dos 20 anos da Revista Estudos Feministas, busco articular o debate sobreteoria e movimento social para apresentar alguns desafios que estão postos para as publicaçõesfeministas. Trato dos desafios ligados ao reconhecimento, à sustentabilidade, às linhas editoriaise à relação universidade e movimento. Concluo afirmando que o principal desafio daspublicações feministas é articular a produção teórica e as pesquisas feministas às lutas e àsformas organizativas que o movimento feminista constrói em cada contexto histórico.

The Effect of Founder Family Influence on Hedging and Speculation

DEFF Research Database (Denmark)

Aabo, Tom; Kuhn, Jochen; Zanotti, Giovanna

We investigate the effect of founder family influence in the form of managers, board of directors, and/or ownership on hedging and speculation in medium-sized, manufacturing firms in Denmark. On a crude measure of use / non-use of derivatives we find only a weak indication of differences between...... founder family firms and other firms in relation to their management of foreign exchange rate, interest rate, and commodity price exposures. Digging deeper into a subsample of users of foreign exchange derivatives and debt denominated in foreign currency, we find that founder family firms not only tend...

Res Publica tahab muuta Riigikogu kuluhüvitiste süsteemi / Alari Rammo

Index Scriptorium Estoniae

Rammo, Alari

2003-01-01

Riigikogu Res Publica fraktsiooni ettepanekutest reformida Riigikogu liikmetele ette nähtud kuluhüvitiste süsteemi. Tabel: Kasutatud kuluhüvitised seisuga 15. oktoober 2003. Kommenteerib Urmo Kübar

Res Publica nõuab rea võimulubaduste täitmist / Rasmus Kagge

Index Scriptorium Estoniae

Kagge, Rasmus, 1977-

2005-01-01

Res Publica lubas koalitsioonipartneritele mitte minna koalitsioonileppe kallale, kui nad toetavad toppama jäänud lubaduste täitmist - haridusreformi, presidendi otsevalimiste seadustamist, riigikontrollile ka omavalitsuste kontrollimiseks õiguse andmist ja lapsevanema tulumaksuvaba miinimumi kahekordistamist alates pere teisest lapsest. Lisa: Võimuliitlaste soovid

Res Publica alustas Tallinnas koostööd Keskerakonnaga / Siim Männik

Index Scriptorium Estoniae

Männik, Siim

2005-01-01

Ilmunud ka: Vabariik (venek.) 18. apr. lk. 2. Koalitsioonivahetusest Tallinnas. Linnavolikogu Res Publica fraktsiooni esimehe Andres Korgi, linnapea Tõnis Paltsi nõuniku Jaano Martin Otsa kommentaare. Tallinna linnapea hinnangul on sügisel koalitsiooni asudes seatud eesmärgid praeguseks peaaegu saavutatud

Res Publica nõuab veel üht abilinnapea kohta / Urmas Seaver

Index Scriptorium Estoniae

Seaver, Urmas, 1973-

2005-01-01

Tallinna linnapea Tõnis Palts on seisukohal, et Reformierakond surus koalitsiooni moodustamisel Res Publicale peale ebaõiglase vastutusvaldkondade jaotuse. Res Publica peasekretär Ott Lumi ei välista võimuliidu loomist Keskerakonnaga, kui Reformierakond järeleandmisi ei tee. ERL tegi ettepaneku kokku kutsuda erakondade ümarlaud. Vt. samas intervjuud Ott Lumiga

Identification of kin structure among Guam rail founders: a comparison of pedigrees and DNA profiles

Science.gov (United States)

Haig, Susan M.; Ballou, J.D.; Casna, N.J.

1994-01-01

Kin structure among founders can have a significant effect on subsequent population structure. Here we use the correlation between DNA profile similarity and relatedness calculated from pedigrees to test hypotheses regarding kin structure among founders to the captive Guam rail (Rallus owstoni) population. Five different pedigrees were generated under the following hypotheses: (i) founders are unrelated; (ii) founders are unrelated except for same-nest chicks; (iii) founders from the same major site are siblings; (iv) founders from the same local site are siblings; and (v) founders are related as defined by a UPGMA cluster analysis of DNA similarity data. Relatedness values from pedigrees 1, 2 and 5 had the highest correlation with DNA similarity but the correlation between relatedness and similarity were not significantly different among pedigrees. Pedigree 5 resulted in the highest correlation overall when using only relatedness values that changed as a result of different founder hypotheses. Thus, founders were assigned relatedness based on pedigree 5 because it had the highest correlations with DNA similarity, was the most conservative approach, and incorporated all field data. The analyses indicated that estimating relatedness using DNA profiles remains problematic, therefore we compared mean kinship, a measure of genetic importance, with mean DNA profile similarity to determine if genetic importance among individuals could be determined via use of DNA profiles alone. The significant correlation suggests this method may provide more information about population structure than was previously thought. Thus, DNA profiles can provide a reasonable explanation for founder relatedness and mean DNA profile similarity may be helpful in determining relative genetic importance of individuals when detailed pedigrees are absent.

Founder Control, Ownership Structure and Firm Value: Evidence from Entrepreneurial Listed Firms in China

Directory of Open Access Journals (Sweden)

Lijun Xia

2008-06-01

Full Text Available In emerging markets, the deviation between the ultimate controlling shareholders' voting rights and their cash flow rights (hereafter “DVC” in the listed firms is quite prevalent. DVC could be introduced due to the ultimate controlling shareholders' opportunistic incentives, as well as by their incentives to improve firm efficiency. This study uses 229 listed firms ultimately controlled by individuals or families (hereafter “entrepreneurial firms” for 2004 in China, to investigate the effect of DVC on firm value and to determine whether it is different between founder and non-founder controlled firms. We find that DVC has a positive effect on firm value for founder controlled firms. This result implies that investors believe that their interests are better protected by founder controlled firms than by non-founder controlled firms.

Res Publica ja Isamaaliit ühendavad jõud / Urmo Kübar, Rauno Veri

Index Scriptorium Estoniae

Kübar, Urmo, 1978-

2006-01-01

Res Publica esimees Taavi Veskimägi ja Isamaaliidu esimees Tõnis Lukas kirjutasid alla ühiste kavatsuste deklaratsioonile, milles nad teevad ettepaneku moodustada ühine erakond. Lisad: Erakonna Eesti Eest deklaratsioon; Lühiülevaade ajaloost

O marketing direto como canal de marketing no setor de publicações periódicas (revistas e jornais) em São Paulo

OpenAIRE

Kato, Heitor Takashi

2010-01-01

Trata da utilização do marketing direto como canal de marketing para as empresas editoras de publicações periódicas em São Paulo. Conceitua o marketing direto e descreve suas variantes. Faz um breve histórico das publicações periódicas e do papel das assinaturas desde sua origem. Utilizando-se do esquema teórico de Aspinwall e do estudo do caso de empresas de publicações periódicas em São Paulo, analisa o potencial da utilização do marketing direto como canal de marketing para outras categori...

Founders at work stories of startups'' early days

CERN Document Server

Livingston, Jessica

2008-01-01

Livingston presents a collection of interviews with founders of famous technology companies about what happens in the very earliest days. Includes interviews with Steve Wozniak (Apple), Max Levchin (PayPal), and others.

The advantage of experienced start-up founders in venture capital acquisition: evidence from serial entrepreneurs

OpenAIRE

Zhang, Junfu

2007-01-01

Existing literature suggests that entrepreneurs with prior firm-founding experience have more skills and social connections than novice entrepreneurs. Such skills and social connections could give experienced founders some advantage in the process of raising venture capital. This paper uses a large database of venture-backed companies and their founders to examine experienced founders' access to venture capital. Compared to novice entrepreneurs, entrepreneurs with venture-backed founding expe...

Business strategy versus human resources strategy: the influence of the founder in small business

Directory of Open Access Journals (Sweden)

Juliana Popp Barbosa Lima

2016-12-01

Full Text Available Small and medium-sized businesses with familiar characteristics have been object of study in recent years, especially about the succession process, considering it is extremely critical to the longevity and sustainability of the organization. However, the figure of the founder and its impact in these organizations is less explored in academia. Thus, this article seeks to fill this gap, addressing the influences of the founder in the dissemination of business and HR strategies in these companies. Through a qualitative and quantitative research, there was a case of a single organization study seeking further analysis of the subject. The collection of qualitative data was given through an interview with semi-structured interview with the founder of the organization and the qualitative by applying a questionnaire with closed questions with officials of various hierarchical levels. It was observed that the personal values and the founding principles are permeated the organization, reflected in the mission and values of the company, as well as how the founder treats topics such as business strategy and the role of people management are decisive for inclusion and driving these topics within family-based organizations. The purpose of analyzing the spread of business strategies and human resources of the Founder has been reached. It was found that, in general, strategies portray the way of the Founder, however, the spread of these to the various hierarchical levels, demonstrates a more complex, as in the HRM.

Evaluating the importance of metamorphism in the foundering of continental crust.

Science.gov (United States)

Chapman, Timothy; Clarke, Geoffrey L; Piazolo, Sandra; Daczko, Nathan R

2017-10-12

The metamorphic conditions and mechanisms required to induce foundering in deep arc crust are assessed using an example of representative lower crust in SW New Zealand. Composite plutons of Cretaceous monzodiorite and gabbro were emplaced at ~1.2 and 1.8 GPa are parts of the Western Fiordland Orthogneiss (WFO); examples of the plutons are tectonically juxtaposed along a structure that excised ~25 km of crust. The 1.8 GPa Breaksea Orthogneiss includes suitably dense minor components (e.g. eclogite) capable of foundering at peak conditions. As the eclogite facies boundary has a positive dP/dT, cooling from supra-solidus conditions (T > 950 ºC) at high-P should be accompanied by omphacite and garnet growth. However, a high monzodioritic proportion and inefficient metamorphism in the Breaksea Orthogneiss resulted in its positive buoyancy and preservation. Metamorphic inefficiency and compositional relationships in the 1.2 GPa Malaspina Pluton meant it was never likely to have developed densities sufficiently high to founder. These relationships suggest that the deep arc crust must have primarily involved significant igneous accumulation of garnet-clinopyroxene (in proportions >75%). Crustal dismemberment with or without the development of extensional shear zones is proposed to have induced foundering of excised cumulate material at P > 1.2 GPa.

Plágio e publicação científica

Directory of Open Access Journals (Sweden)

André Luís Gemal

2015-05-01

Full Text Available Nos últimos anos, a palavra ética tem estado em evidência no país, usualmente referida a sua ausência. Neste cenário, no qual sobram palavras e faltam atitudes, refletir, debater e concretizar ações sobre este tema na publicação científica tornam-se imprescindíveis. O acesso aberto e a democratização do conhecimento e, principalmente, da informa-ção, têm permitido atualmente uma possibilidade fabulosa de avanços na formação de pesquisadores e cidadãos.Neste contexto, a cultura do plágio tem maiores condições de se disseminar e de se tornar socialmente aceita. Isto faz com que instituições e editores de revistas científicas sejam colocados em situações que exigem atitudes imediatas e coerentes com os princípios éti-cos do campo da ciência. Em uma rápida busca no Google do termo “plágio em publicação científica”, encontramos cerca de 400 mil resultados, o que evidencia os danos e riscos que dizem respeito a todos nós: editores, pesquisadores, alunos, gestores de instituições de pesquisa — corresponsáveis pela acuidade da informação — e leitores.

Cancer risks and immunohistochemical profiles linked to the Danish MLH1 Lynch syndrome founder mutation

DEFF Research Database (Denmark)

Therkildsen, Christina; Isinger-Ekstrand, Anna; Ladelund, Steen

2012-01-01

Founder mutations with a large impact in distinct populations have been described in Lynch syndrome. In Denmark, the MLH1 c.1667+2_1667_+8TAAATCAdelinsATTT mutation accounts for 25 % of the MLH1 mutant families. We used the national Danish hereditary nonpolyposis colorectal cancer register...... to estimate the cumulative lifetime risks for Lynch syndrome-associated cancer in 16 founder mutation families with comparison to 47 other MLH1 mutant families. The founder mutation conferred comparable risks for colorectal cancer (relative risks, RR, of 0.99 for males and 0.79 for females) and lower risks...... in 68 % with extensive inter-tumor variability despite the same underlying germline mutation. In conclusion, the Danish MLH1 founder mutation that accounts for a significant proportion of Lynch syndrome and is associated with a lower risk for extracolonic cancers....

A qualidade das publicações científicas: considerações de um Editor de Área ao final do mandato

OpenAIRE

Albuquerque,Ulysses Paulino de

2009-01-01

A qualidade das publicações científicas vem sendo discutida na atualidade considerando diferentes perspectivas. Neste texto, examina-se alguns dos principais problemas relativos à produção textual em ciência, com ênfase para os considerados de má conduta. Adicionalmente, são apresentadas sugestões para autores, revisores e editores no sentido de evitar condutas inadequadas no processo de publicação de trabalhos científicos.

Características bibliométricas e sociométricas de publicações da área ambiental em congressos e períodicos nacionais

Directory of Open Access Journals (Sweden)

Ilse Maria Beuren

2014-03-01

Full Text Available http://dx.doi.org/10.5007/1983-4535.2014v7n1p234 O estudo objetiva examinar características bibliométricas e sociométricas de publicações da área ambiental no Congresso USP de Controladoria e Contabilidade, EnANPAD e em periódicos de Administração e Contabilidade no período de 2000 a 2010. Pesquisa descritiva com abordagem quantitativa foi realizada por meio de pesquisa documental. Os resultados da pesquisa bibliométrica destacam que: i o volume de publicações sobre o tema no EnANPAD aumentou significativamente no decorrer do período analisado; ii os periódicos O&S, RAE, RAUSP e REAd apresentam tendência ascendente no volume de publicações sobre o tema; iii quanto aos procedimentos metodológicos, o Congresso USP e o EnANPAD priorizaram estudos de caso e survey e os periódicos estudos teóricos, mas em todos prevaleceu a abordagem qualitativa; iv dentre as categorias da temática ambiental prevaleceu a Gestão Ambiental e evolução nas publicações sobre Evidenciação Ambiental. Os resultados da pesquisa sociométrica revelam que a configuração estrutural dos relacionamentos dos autores prepondera nos congressos e há alguns autores que possuem laços de publicações com autores de outros periódicos. Conclui-se que as características bibliométricas e sociométricas das publicações da área ambiental sinalizam que o tema continua em evidência e que a configuração estrutural dos relacionamentos dos autores apresenta lacunas principalmente nos periódicos pesquisados.

Investigações sobre o ensino de Genética e Biologia Molecular no Ensino Médio brasileiro: reflexões sobre as publicações científicas

OpenAIRE

Melo,José Romário de; Carmo,Edinaldo Medeiros

2009-01-01

Com o objetivo de analisar as publicações relacionadas ao ensino de Genética e Biologia Molecular no Ensino Médio brasileiro, foram consideradas reflexões sobre várias publicações científicas mediante revisão bibliográfica. Foram analisados trabalhos publicados entre 1999 a 2008. A Revista Genética na Escola se destacou quanto à quantidade de artigos publicados. As publicações puderam ser classificadas em diversas categorias, como: análise de livro didático (ALD), histórico (HIS), intrainterd...

Founder effects and genetic population structure of brown trout (Salmo trutta) in a Danish river system

DEFF Research Database (Denmark)

Hansen, Michael Møller; Mensberg, Karen-Lise Dons

1996-01-01

The influence of founder effects on the genetic population structure of brown trout (Salmo trutta) was studied in a small Danish river system. Samples of trout from seven locations were analysed by allozyme electrophoresis and mitochondrial DNA restriction fragment length polymorphism analysis....... For comparison, allozyme data from other Danish trout populations and mtDNA data from two hatchery strains were included. Genetic differentiation among populations was found to be small but significant. Pairwise tests for homogeneity of allele and haplotype frequencies between samples showed that significance...... simulations of the influence of founder effects on mitochondrial DNA differentiation and variability showed that the observed divergence could be due either to natural founder effects or to a genetic contribution by hatchery trout. However, the allozyme results pointed towards natural founder effects...

Founder of a scientific school on plasma

International Nuclear Information System (INIS)

Anon

2003-01-01

The academician Mikhail Aleksandrovitch Leontovitch is a physicist-theorist of a wide profile (physical optics, oscillation theory, acoustics, statistical physics, thermodynamics), who became the founder of the largest scientific schools on the radiophysics and plasma physics. Namely due to his effective leadership in developing the theory our theoretical studies on the controlled thermonuclear synthesis reached high level and facilitated the success of the experiment [ru

The scribe of the founder's inscription of Saint Sava in Studenica

Directory of Open Access Journals (Sweden)

Špadijer Irena

2006-01-01

Full Text Available The founder's inscription situated at the foot of the tambour in the Church of the Virgin in Studenica originating from 1208/9, is one of the oldest dated specimens of Serbian literacy. It was uncovered in 1951, during the conservation works in the monastery. Former research (conducted by Dj. Trifunović, has ascertained that inscriptions on the scrolls, books and frescoes in the monastery were written by the Greek artists who decorated the church. Scribal errors indicate beyond any doubt that Slavic was not the mother tongue of the scribes, and that they were not, or at least not sufficiently, familiar with the orthography of this language. In this paper the main focus has been directed at the founder's inscription, which has been put under detailed orthographic and palaeographic scrutiny. The morphology of some letters — the Greek "K", non-distinguishing between ižica (ippsilon and the Cyrillic "Č" — clearly indicates that in all probability the author of the inscription was a Greek, perhaps the very painter who signed his name in the Greek language on the Mandelion beneath the large founder's inscription.

Isamaa ja Res Publica liit tõotab neile kõrget kohta edetabelis / Rasmus Kagge

Index Scriptorium Estoniae

Kagge, Rasmus, 1977-

2006-01-01

Ilmunud ka: Postimees : na russkom jazõke 10. apr. lk. 7. TNS Emori märtsikuu erakondade populaarsusuuringu tulemused näitavad, et Res Publicaga liituda otsustanud Isamaaliit on tõusnud poliitedetabelis kolmandale kohale. Res Publica reiting on endiselt madal, edetabelit juhib Keskerakond. Diagrammid: Isamaaliit kogub toetajaid tõusvas tempos. Vt. samas: Ühendpartei Eesti Eest! otsib endale uut nime

Characterization of a mutation commonly associated with persistent stuttering: evidence for a founder mutation

Science.gov (United States)

Fedyna, Alison; Drayna, Dennis; Kang, Changsoo

2010-01-01

Stuttering is a disorder which affects the fluency of speech. It has been shown to have high heritability, and has recently been linked to mutations in the GNPTAB gene. One such mutation, Glu1200Lys, has been repeatedly observed in unrelated families and individual cases. Eight unrelated individuals carrying this mutation were analyzed in an effort to distinguish whether these arise from repeated mutation at the same site, or whether they represent a founder mutation with a single origin. Results show that all 12 chromosomes carrying this mutation share a common haplotype in this region, indicating it is a founder mutation. Further analysis estimated the age of this allele to be ~572 generations. Construction of a cladogram tracing the mutation through our study sample also supports the founder mutation hypothesis. PMID:20944643

Venelastest Res Publica toetajad Ida-Virus võivad uuele parteile selja pöörata / Erik Kalda

Index Scriptorium Estoniae

Kalda, Erik, 1969-

2006-01-01

Ilmunud ka: Severnoje Poberezhje 6. apr. lk. 3, Narvskaja Nedelja 8. apr. lk. 2. Suur osa Ida-Virumaal elavatest Res Publica liikmetest ning toetajatest ei poolda erakonna ühinemist Isamaaliiduga, sest paljude venelaste meelest on Isamaaliit nende huve eirav partei

Do VCs use inside rounds to dilute founders? Some evidence from Silicon Valley

OpenAIRE

Fried, Jesse M.; Broughman, Brian J.

2012-01-01

In the bank-borrower setting, a firm’s existing lender may exploit its positional advantage to extract rents from the firm in subsequent financings. Analogously, a startup’s existing venture capital investors (VCs) may dilute the founder through a follow-on financing from these same VCs (an “inside” round) at an artificially low valuation. Using a hand-collected dataset of Silicon Valley startup firms, we find little evidence that VCs use inside rounds to dilute founders. Instead, our finding...

Ken-Marti Vaher : Paremjõudude ühinemine on Res Publica esmane ülesanne / Ken-Marti Vaher ; interv. Tanel Mazur

Index Scriptorium Estoniae

Vaher, Ken-Marti, 1974-

2004-01-01

Ilmunud ka: Narvskaja Gazeta, 6. nov. 2004, lk. 2. Ida-Virumaad külastanud justiitsminister Ken-Marti Vaher Rakveres ja Narvas arutatust, praeguse võimupartei Res Publica seisukohtadest, tulevikuplaanidest

Análise das publicações dos enfermeiros assistenciais em periódicos nacionais

Directory of Open Access Journals (Sweden)

Ana Maria Dyniewicz

2010-12-01

Full Text Available Esta pesquisa identificou a participação de enfermeiras assistenciais em publicações. Foi realizada revisão bibliográfica em três periódicos nacionais entre 2000 a 2007, somando 1.918 artigos. A enfermeira assistencial esteve como autora ou co-autora em 162 artigos (8.5%; em 75 publicações não houve identificação de sua titulação. Os doutores foram os que mais publicaram com enfermeiras e as áreas com maior número de artigos: educação em saúde e enfermagem, saúde do adulto e idoso. Concluiu-se que as enfermeiras têm maior facilidade em publicar em grupos de pesquisas e que ao assumirem a prática, mesmo depois de pós-graduação, não mantêm a produção científica. Há necessidade de maior empenho de toda a categoria profissional para ampliar essa participação em periódicos.

The workforce composition of young firms and product innovation - complementarities in the skills of founders and their early employees

OpenAIRE

Müller, Bettina; Murmann, Martin

2016-01-01

We investigate the extent to which complementarities between technical and business skills of founders and employees matter for the generation of market novelties by new ventures. Using data about German start-ups, we find that there are no complementarities between technical and business skills within the group of founders, but that there are significant complementarities between technically trained founders and employees who have business skills. This suggests that the innovation potenti...

A common Greenlandic Inuit BRCA1 RING domain founder mutation

DEFF Research Database (Denmark)

Hansen, T.v.O.; Ejlertsen, B.; Albrechtsen, Anders

2009-01-01

of the families had members with ovarian cancer, suggesting that the RING domain may be an ovarian cancer hotspot. By SNP array analysis, we find that all 13 families share a 4.5 Mb genomic fragment containing the BRCA1 gene, showing that the mutation originates from a founder. Finally, analysis of 1152 Inuit......, representing almost ~2% of the total Greenlandic Inuit population, showed that the frequency of the mutation was 1.0%. We conclude that the BRCA1 nucleotide 234 T > G is a common Greenlandic Inuit founder mutation. The relative high frequency in the general population, together with the ease of screening...... and possibility to reduce mortality in gene carriers, may warrant screening of the Greenlandic Inuit population. Provided screening is efficient, about 5% of breast- and 13% of ovarian cancers, respectively, may be prevented Udgivelsesdato: 2009/5...

Juugendloss Eestimaa ääre peal / Helju Koger

Index Scriptorium Estoniae

Koger, Helju, 1943-

2003-01-01

Aastaid raviasutusena tegutsenud Taagepera loss avas mais 2003 oma uksed hotelli ja konverentsikeskusena. 1912. a. valminud jugendhäärberi projekteeris Otto Wildau. Hoone omanikest, arhitektuurist. Hotelli sisekujunduse tegi Kadri Tarbe. Lossis on avatud harrastusfotograaf Peeter Sepa näitus "Eestimaa tagumises sopis Taageperas", keraamik Marget Tafeli näitus "Dora aarded", Leonhard Lapini ja Ülevi Eljandi näitus "Sõbrad SOUP 69-st". 16 ill

Association of yield-related traits in founder genotypes and derivatives of common wheat (Triticum aestivum L.

Directory of Open Access Journals (Sweden)

Jie Guo

2018-02-01

Full Text Available Abstract Background Yield improvement is an ever-important objective of wheat breeding. Studying and understanding the phenotypes and genotypes of yield-related traits has potential for genetic improvement of crops. Results The genotypes of 215 wheat cultivars including 11 founder parents and 106 derivatives were analyzed by the 9 K wheat SNP iSelect assay. A total of 4138 polymorphic single nucleotide polymorphism (SNP loci were detected on 21 chromosomes, of which 3792 were mapped to single chromosome locations. All genotypes were phenotyped for six yield-related traits including plant height (PH, spike length (SL, spikelet number per spike (SNPS, kernel number per spike (KNPS, kernel weight per spike (KWPS, and thousand kernel weight (TKW in six irrigated environments. Genome-wide association analysis detected 117 significant associations of 76 SNPs on 15 chromosomes with phenotypic explanation rates (R 2 ranging from 2.03 to 12.76%. In comparing allelic variation between founder parents and their derivatives (106 and other cultivars (98 using the 76 associated SNPs, we found that the region 116.0–133.2 cM on chromosome 5A in founder parents and derivatives carried alleles positively influencing kernel weight per spike (KWPS, rarely found in other cultivars. Conclusion The identified favorable alleles could mark important chromosome regions in derivatives that were inherited from founder parents. Our results unravel the genetic of yield in founder genotypes, and provide tools for marker-assisted selection for yield improvement.

The nuclear power policy in Argentina (1965-2003); La politica publica de generacion nucleoelectrica en la Republica Argentina (1965-2003)

Energy Technology Data Exchange (ETDEWEB)

Carreiro, Francisco M [Buenos Aires Univ. (Argentina). Facultad de Ciencias Economicas

2005-07-01

This paper aims to expose some outcomes of a larger research on the nuclear power plants public policy review in Argentine, between 1965 and 2003. It points out the relevance of institutional design as a main factor to explain the policy evolution, and offers unpublished statistic data of this nuclear energy sector. Finally, some comments are presented in order to highlight the importance of the unsolved policy aspects that concern the decision makers in this area. (author) [Spanish] El presente trabajo deriva de un estudio integral desde la optica de la politica publica, y tiene como objetivo el analisis de la evolucion de la politica publica de generacion nucleoelectrica en la Republica Argentina entre los anios 1965 y 2003. (autor)

Differences in the Selection Bottleneck between Modes of Sexual Transmission Influence the Genetic Composition of the HIV-1 Founder Virus.

Directory of Open Access Journals (Sweden)

Damien C Tully

2016-05-01

Full Text Available Due to the stringent population bottleneck that occurs during sexual HIV-1 transmission, systemic infection is typically established by a limited number of founder viruses. Elucidation of the precise forces influencing the selection of founder viruses may reveal key vulnerabilities that could aid in the development of a vaccine or other clinical interventions. Here, we utilize deep sequencing data and apply a genetic distance-based method to investigate whether the mode of sexual transmission shapes the nascent founder viral genome. Analysis of 74 acute and early HIV-1 infected subjects revealed that 83% of men who have sex with men (MSM exhibit a single founder virus, levels similar to those previously observed in heterosexual (HSX transmission. In a metadata analysis of a total of 354 subjects, including HSX, MSM and injecting drug users (IDU, we also observed no significant differences in the frequency of single founder virus infections between HSX and MSM transmissions. However, comparison of HIV-1 envelope sequences revealed that HSX founder viruses exhibited a greater number of codon sites under positive selection, as well as stronger transmission indices possibly reflective of higher fitness variants. Moreover, specific genetic "signatures" within MSM and HSX founder viruses were identified, with single polymorphisms within gp41 enriched among HSX viruses while more complex patterns, including clustered polymorphisms surrounding the CD4 binding site, were enriched in MSM viruses. While our findings do not support an influence of the mode of sexual transmission on the number of founder viruses, they do demonstrate that there are marked differences in the selection bottleneck that can significantly shape their genetic composition. This study illustrates the complex dynamics of the transmission bottleneck and reveals that distinct genetic bottleneck processes exist dependent upon the mode of HIV-1 transmission.

Avaliação do autoconceito no contexto escolar: análise das publicações em periódicos brasileiros

Directory of Open Access Journals (Sweden)

Adriana Cristina Boulhoça Suehiro

Full Text Available Visando a levantar as publicações dos últimos dez anos referentes à avaliação do autoconceito no contexto escolar, o presente estudo avaliou artigos encontrados nos periódicos classificados como Nacional A pela CAPES. Os dados evidenciaram poucas publicações voltadas para a avaliação do construto. Mesmo os periódicos específicos de Psicologia escolar e educacionalpassaram a publicar artigos sobre o assunto somente a partir de 2005. Nas análises por Região, autoria e amostras, o Sudeste apresentou maior concentração de artigos publicados. Foi identificado o uso mais freqüente da autoria múltipla e a realização de estudos envolvendo crianças. As referências apresentaram mais artigos e livros, com predominância da literatura internacional. Quanto aos instrumentos de avaliação, os mais utilizados foram a Escala Infantil Piers-Harris e a Escala de Autoconceito Infanto-Juvenil EAC-IJ. Por fim, o presente estudo atesta a necessidade de novas publicações voltadas para a avaliação do autoconceito no contexto escolar, guiado pela importância do construto no processo de aprendizagem.

Clinical applications and implications of common and founder mutations in Indian subpopulations.

Science.gov (United States)

Ankala, Arunkanth; Tamhankar, Parag M; Valencia, C Alexander; Rayam, Krishna K; Kumar, Manisha M; Hegde, Madhuri R

2015-01-01

South Asian Indians represent a sixth of the world's population and are a racially, geographically, and genetically diverse people. Their unique anthropological structure, prevailing caste system, and ancient religious practices have all impacted the genetic composition of most of the current-day Indian population. With the evolving socio-religious and economic activities of the subsects and castes, endogamous and consanguineous marriages became a commonplace. Consequently, the frequency of founder mutations and the burden of heritable genetic disorders rose significantly. Specifically, the incidence of certain autosomal-recessive disorders is relatively high in select Indian subpopulations and communities that share common recent ancestry. Although today clinical genetics and molecular diagnostic services are making inroads in India, the high costs associated with the technology and the tests often keep patients from an exact molecular diagnosis, making more customized and tailored tests, such as those interrogating the most common and founder mutations or those that cater to select sects within the population, highly attractive. These tests offer a quick first-hand affordable diagnostic and carrier screening tool. Here, we provide a comprehensive catalog of known common mutations and founder mutations in the Indian population and discuss them from a molecular, clinical, and historical perspective. © 2014 WILEY PERIODICALS, INC.

What founders in developing countries learn about organizing microenterprise growth

DEFF Research Database (Denmark)

Pötz, Katharina Anna; Hjortsø, Carsten Nico Portefée

organizational failure. In this regard, we find that only those founders that rapidly make sense of ineffective processes, gain management knowledge from different sources, and devote time and energy to managerial tasks, manage to sustain organizational growth by learning to make ‘fixes’ for internal problems...

Subspecies composition and founder contribution of the captive U.S. chimpanzee (Pan troglodytes) population.

Science.gov (United States)

Ely, John J; Dye, Brent; Frels, William I; Fritz, Jo; Gagneux, Pascal; Khun, Henry H; Switzer, William M; Lee, D Rick

2005-10-01

Chimpanzees are presently classified into three subspecies: Pan troglodytes verus from west Africa, P.t. troglodytes from central Africa, and P.t. schweinfurthii from east Africa. A fourth subspecies (P.t. vellerosus), from Cameroon and northern Nigeria, has been proposed. These taxonomic designations are based on geographical origins and are reflected in sequence variation in the first hypervariable region (HVR-I) of the mtDNA D-loop. Although advances have been made in our understanding of chimpanzee phylogenetics, little has been known regarding the subspecies composition of captive chimpanzees. We sequenced part of the mtDNA HVR-I region in 218 African-born population founders and performed a phylogenetic analysis with previously characterized African sequences of known provenance to infer subspecies affiliations. Most founders were P.t. verus (95.0%), distantly followed by the troglodytes schweinfurthii clade (4.6%), and a single P.t. vellerosus (0.4%). Pedigree-based estimates of genomic representation in the descendant population revealed that troglodytes schweinfurthii founder representation was reduced in captivity, vellerosus representation increased due to prolific breeding by a single male, and reproductive variance resulted in uneven representation among male P.t.verus founders. No increase in mortality was evident from between-subspecies interbreeding, indicating a lack of outbreeding depression. Knowledge of subspecies and their genomic representation can form the basis for phylogenetically informed genetic management of extant chimpanzees to preserve rare genetic variation for research, conservation, or possible future breeding. Copyright 2005 Wiley-Liss, Inc.

A novel FKRP-related muscular dystrophy founder mutation in South ...

African Journals Online (AJOL)

porphyria variegata, familial hypercholesterolaemia, Gaucher's dis- ease and autosomal recessive polycystic kidney disease.[7-11]. FKRP founder mutations have been described in a number of populations around the world, for example the c.826C>A. (p.Leu276Ile) FKRP mutation in 20 LGMD German patients[12].

A Dutch Fanconi Anemia FANCC Founder Mutation in Canadian Manitoba Mennonites

Directory of Open Access Journals (Sweden)

Yne de Vries

2012-01-01

Full Text Available Fanconi anemia (FA is a recessive DNA instability disorder associated with developmental abnormalities, bone marrow failure, and a predisposition to cancer. Based on their sensitivity to DNA cross-linking agents, FA cells have been assigned to 15 complementation groups, and the associated genes have been identified. Founder mutations have been found in different FA genes in several populations. The majority of Dutch FA patients belongs to complementation group FA-C. Here, we report 15 patients of Dutch ancestry and a large Canadian Manitoba Mennonite kindred carrying the FANCC c.67delG mutation. Genealogical investigation into the ancestors of the Dutch patients shows that these ancestors lived in four distinct areas in The Netherlands. We also show that the Dutch and Manitoba Mennonite FANCC c.67delG patients share the same haplotype surrounding this mutation, indicating a common founder.

Análisis de los factores que dieron emergencia y desarrollo a la política publica del salario mínimo en Colombia, 1934- 1945

OpenAIRE

González Mejía, Mariana

2013-01-01

Este trabajo de grado es una recopilación bibliográfica de múltiples factores nacionales e internacionales que pueden explicar la emergencia y desarrollo de la política publica del salario mínimo en Colombia. Todo esto esta cubierto bajo la definición de política publica de Raúl Velasquez. La relevancia del trabajo esta en que se hace el estudio de un fenómeno económico desde el lado social.

Utilization of founder lines for improved Citrus biotechnology via RMCE

Science.gov (United States)

On October 1st 2011 the CRB chose to fund a unique research project, the development of citrus cultivars specifically for genetic engineering (GE). The objective of this research was to develop GE citrus ‘Founder Lines’ containing DNA sequences that will allow the precise insertion of genes for de...

Founders of share companies under the Ethiopian share company law

African Journals Online (AJOL)

This article explores the Commercial Code and other laws of Ethiopia regarding founders – who they are, liabilities and benefits - who are also called 'promoters' by many other company laws. To some extent, it also looks into the business practice based on documents like memorandum of associations, articles of ...

The founder-cell transcriptome in the Arabidopsis apetala1 cauliflower inflorescence meristem.

Science.gov (United States)

Frerichs, Anneke; Thoma, Rahere; Abdallah, Ali Taleb; Frommolt, Peter; Werr, Wolfgang; Chandler, John William

2016-11-03

Although the pattern of lateral organ formation from apical meristems establishes species-specific plant architecture, the positional information that confers cell fate to cells as they transit to the meristem flanks where they differentiate, remains largely unknown. We have combined fluorescence-activated cell sorting and RNA-seq to characterise the cell-type-specific transcriptome at the earliest developmental time-point of lateral organ formation using DORNRÖSCHEN-LIKE::GFP to mark founder-cell populations at the periphery of the inflorescence meristem (IM) in apetala1 cauliflower double mutants, which overproliferate IMs. Within the lateral organ founder-cell population at the inflorescence meristem, floral primordium identity genes are upregulated and stem-cell identity markers are downregulated. Additional differentially expressed transcripts are involved in polarity generation and boundary formation, and in epigenetic and post-translational changes. However, only subtle transcriptional reprogramming within the global auxin network was observed. The transcriptional network of differentially expressed genes supports the hypothesis that lateral organ founder-cell specification involves the creation of polarity from the centre to the periphery of the IM and the establishment of a boundary from surrounding cells, consistent with bract initiation. However, contrary to the established paradigm that sites of auxin response maxima pre-pattern lateral organ initiation in the IM, auxin response might play a minor role in the earliest stages of lateral floral initiation.

Estado da Arte da Publicação Nacional e Internacional sobre Neuromarketing e Neuroeconomia

OpenAIRE

Caissa Veloso e Sousa; José Edson Lara; Erich Vale e Sousa; Jefferson Rodrigues Pereira

2016-01-01

Nas últimas três décadas os estudos envolvendo as áreas de Neurociência e Engenharia biomédica e que convergem para a possibilidade de mapeamento e avaliação do cérebro in vivo apresentaram desenvolvimento significativo, possibilitando a emersão, nas ciências sociais, dos campos de pesquisa chamados de Neuromarketing e Neuroeconomia. No presente trabalho foram analisadas as publicações existentes sobre o t...

Editorial: Integridade na pesquisa e ética na publicação

OpenAIRE

Shinkai, Rosemary Sadami Arai

2011-01-01

As exigências de produção intelectual com base nas publicações científicas constituem mecanismos de pressão sobre pesquisadores, docentes e discentes de programas de pós-graduação, uma vez que os indicadores de qualidade acadêmica estão atualmente atrelados à produção bibliográfica tanto no Brasil quanto no exterior. Nesse contexto, tornam-se cada vez mais necessárias políticas editoriais definidas para que o periódico científico exerça seu papel de orientar a comunidade científica sobre boas...

A mitochondrial analysis reveals distinct founder effect signatures in Canarian and Balearic goats.

Science.gov (United States)

Ferrando, A; Manunza, A; Jordana, J; Capote, J; Pons, A; Pais, J; Delgado, T; Atoche, P; Cabrera, B; Martínez, A; Landi, V; Delgado, J V; Argüello, A; Vidal, O; Lalueza-Fox, C; Ramírez, O; Amills, M

2015-08-01

In the course of human migrations, domestic animals often have been translocated to islands with the aim of assuring food availability. These founder events are expected to leave a genetic footprint that may be recognised nowadays. Herewith, we have examined the mitochondrial diversity of goat populations living in the Canarian and Balearic archipelagos. Median-joining network analysis produced very distinct network topologies for these two populations. Indeed, a majority of Canarian goats shared a single ancestral haplotype that segregated in all sampled islands, suggesting a single founder effect followed by a stepping-stone pattern of diffusion. This haplotype also was present in samples collected from archaeological assemblies at Gran Canaria and Lanzarote, making evident its widespread distribution in ancient times. In stark contrast, goats from Majorca and Ibiza did not share any mitochondrial haplotypes, indicating the occurrence of two independent founder events. Furthermore, in Majorcan goats, we detected the segregation of the mitochondrial G haplogroup that has only been identified in goats from Egypt, Iran and Turkey. This finding suggests the translocation of Asian and/or African goats to Majorca, possibly as a consequence of the Phoenician and Carthaginian colonisations of this island. © 2015 Stichting International Foundation for Animal Genetics.

Haplotype analysis suggest that the MLH1 c.2059C > T mutation is a Swedish founder mutation.

Science.gov (United States)

von Salomé, Jenny; Liu, Tao; Keihäs, Markku; Morak, Moni; Holinski-Feder, Elke; Berry, Ian R; Moilanen, Jukka S; Baert-Desurmont, Stéphanie; Lindblom, Annika; Lagerstedt-Robinson, Kristina

2017-12-29

Lynch syndrome (LS) predisposes to a spectrum of cancers and increases the lifetime risk of developing colorectal- or endometrial cancer to over 50%. Lynch syndrome is dominantly inherited and is caused by defects in DNA mismatch-repair genes MLH1, MSH2, MSH6 or PMS2, with the vast majority detected in MLH1 and MSH2. Recurrent LS-associated variants observed in apparently unrelated individuals, have either arisen de novo in different families due to mutation hotspots, or are inherited from a founder (a common ancestor) that lived several generations back. There are variants that recur in some populations while also acting as founders in other ethnic groups. Testing for founder mutations can facilitate molecular diagnosis of Lynch Syndrome more efficiently and more cost effective than screening for all possible mutations. Here we report a study of the missense mutation MLH1 c.2059C > T (p.Arg687Trp), a potential founder mutation identified in eight Swedish families and one Finnish family with Swedish ancestors. Haplotype analysis confirmed that the Finnish and Swedish families shared a haplotype of between 0.9 and 2.8 Mb. While MLH1 c.2059C > T exists worldwide, the Swedish haplotype was not found among mutation carriers from Germany or France, which indicates a common founder in the Swedish population. The geographic distribution of MLH1 c.2059C > T in Sweden suggests a single, ancient mutational event in the northern part of Sweden.

THE INFLUENCE OF THE COMPETENCES OF THE MANAGER: FOUNDER ON THE SUCCESS OF THE ORGANIZATION

Directory of Open Access Journals (Sweden)

Ace Milenkovski

2013-06-01

Full Text Available The environment, where the changes are everyday occurrence and the competition continuous threat, forces the leading people in the organizations to look after everything that goes on inside the organizations, as well as everything that goes on outside of them. Thus, depending on the founder’s capability, respectively the manager of the organization, the success of the organization can go up or down. The individuals that have entrepreneurial spirit, that know how to combine their knowledge, education and work experience with the successful guiding of the employees toward the goal, strengthen their business and open possibilities for its expansion.If under competence we imply to the knowledge of business, working experience and skills necessary for effective performance at the workplace, then undoubtedly the entrepreneur–founder in order to obtain the optimum knowledge for the business that he starts, previously has to build his competences through appropriate education and work experience.Herein we present working research conducted in order to prove the connection of the organization’s success with the knowledge, skills and competences for the corresponding business of the organization’s founder, particularly if the founder is also general manager of the organization. This research is conducted within the frames of the scientific and research activity of the University of Tourism and Management in Skopje, FYRO Macedonia.As a research sample 271 respondents – employees and 10 leaders of the companies included in the research. The leaders are managers and founders of the private companies. As a research technique questionnaire is used. Practical aim of the research was to use the results in order to create a basis for improving the performance of companies by developing the competencies of the management teams in them. One of the main conclusions of the research is: The manager-founder who starts up a business, needs to have optimum

50 years of Dutch immunology--founders, institutions, highlights.

Science.gov (United States)

Gmelig-Meyling, Frits H J; Meyaard, Linde; Mebius, Reina E

2014-12-01

At the occasion of the 50th anniversary of the Dutch Society for Immunology (DSI, de Nederlandse Vereniging voor Immunologie), this contribution deals with some highlights of 50 years of Immunology in the Netherlands. It narrates about the founders and first board members of the DSI, their institutes, progeny and patrimony, describes major centers of immunological activities, mentions key persons in the field, and touches upon some events dear to the Society and its members. Copyright © 2014 Elsevier B.V. All rights reserved.

O metifenidato no Brasil: uma década de publicações Methylphenidate in Brazil: a decade of publications

Directory of Open Access Journals (Sweden)

Francisco Ortega

2013-03-01

Full Text Available O metilfenidato é um estimulante comercializado desde os anos 50 na Suíça, na Alemanha e nos EUA. Mas foi somente a partir de sua associação com o Transtorno do Déficit de Atenção e Hiperatividade (TDAH que suas vendas alavancaram, tornando-se o estimulante mais consumido no mundo. Este artigo tem por objetivo apresentar os resultados de uma análise das publicações brasileiras sobre os usos do metilfenidato no Brasil, ao longo da última década. Com isto, visa compreender como as informações são apresentadas ou omitidas nos diferentes espaços de divulgação impressa. Para tal análise, foram pesquisadas publicações científicas, nos principais periódicos de psiquiatria brasileiros, e reportagens de jornais e revistas nacionais destinados ao público em geral. A pesquisa inclui as publicações do período de 1998 a 2008. Destaca-se como ponto relevante da análise a importante participação dos laboratórios no financiamento dos grupos e pesquisas sobre TDAH. Os achados indicam que a combinação do uso do medicamento com psicoterapias, a dependência do medicamento e a ideia de que existe excesso de prescrição no Brasil são temas controversos nas publicações analisadas.Methylphenidate is frequently associated with Attention Deficit Hyperactivity disorder (ADHD, though this psychostimulant has been on the market in Switzerland, Germany and the US since the 1950s. After its association with ADHD, Ritalin has become the world's most widely used psychostimulant. The scope of this article is to present the results of an analysis of publications concerning the use of Methylphenidate in Brazil over a decade. It seeks to understand how the information is presented or omitted in the different printed materials. For the analysis, the most important Brazilian psychiatric journals as well as major Brazilian newspapers and magazines for the general public for the 1998-2008 period were consulted. One important point that resulted

Highly prevalent LIPH founder mutations causing autosomal recessive woolly hair/hypotrichosis in Japan and the genotype/phenotype correlations.

Directory of Open Access Journals (Sweden)

Kana Tanahashi

Full Text Available Mutations in LIPH cause of autosomal recessive woolly hair/hypotrichosis (ARWH, and the 2 missense mutations c.736T>A (p.Cys246Ser and c.742C>A (p.His248Asn are considered prevalent founder mutations for ARWH in the Japanese population. To reveal genotype/phenotype correlations in ARWH cases in Japan and the haplotypes in 14 Japanese patients from 14 unrelated Japanese families. 13 patients had woolly hair, and 1 patient had complete baldness since birth. An LIPH mutation search revealed homozygous c.736T>A mutations in 10 of the patients. Compound heterozygous c.736T>A and c.742C>A mutations were found in 3 of the patients, and homozygous c.742C>A mutation in 1 patient. The phenotype of mild hypotrichosis with woolly hair was restricted to the patients with the homozygous c.736T>A mutation. The severe phenotype of complete baldness was seen in only 1 patient with homozygous c.742C>A. Haplotype analysis revealed that the alleles containing the LIPH c.736T>A mutation had a haplotype identical to that reported previously, although 4 alleles out of 5 chromosomes containing the LIPH c.742C>A mutation had a different haplotype from the previously reported founder allele. These alleles with c.742C>A are thought to be the third founder LIPH mutation causing ARWH. To accurately determine the prevalence of the founder mutations, we investigated allele frequencies of those mutations in 819 Japanese controls. Heterozygous c.736T>A mutations were found in 13 controls (allele frequency: 0.0079; carrier rate: 0.016, and heterozygous c.742C>A mutations were found in 2 controls (allele frequency: 0.0012; carrier rate: 0.0024. In conclusion, this study confirms the more accurate allele frequencies of the pathogenic founder mutations of LIPH and shows that there is a third founder mutation in Japan. In addition, the present findings suggest that the mutation patterns of LIPH might be associated with hypotrichosis severity in ARWH.

Org-1 is required for the diversification of circular visceral muscle founder cells and normal midgut morphogenesis.

Science.gov (United States)

Schaub, Christoph; Frasch, Manfred

2013-04-15

The T-Box family of transcription factors plays fundamental roles in the generation of appropriate spatial and temporal gene expression profiles during cellular differentiation and organogenesis in animals. In this study we report that the Drosophila Tbx1 orthologue optomotor-blind-related-gene-1 (org-1) exerts a pivotal function in the diversification of circular visceral muscle founder cell identities in Drosophila. In embryos mutant for org-1, the specification of the midgut musculature per se is not affected, but the differentiating midgut fails to form the anterior and central midgut constrictions and lacks the gastric caeca. We demonstrate that this phenotype results from the nearly complete loss of the founder cell specific expression domains of several genes known to regulate midgut morphogenesis, including odd-paired (opa), teashirt (tsh), Ultrabithorax (Ubx), decapentaplegic (dpp) and wingless (wg). To address the mechanisms that mediate the regulatory inputs from org-1 towards Ubx, dpp, and wg in these founder cells we genetically dissected known visceral mesoderm specific cis-regulatory-modules (CRMs) of these genes. The analyses revealed that the activities of the dpp and wg CRMs depend on org-1, the CRMs are bound by Org-1 in vivo and their T-Box binding sites are essential for their activation in the visceral muscle founder cells. We conclude that Org-1 acts within a well-defined signaling and transcriptional network of the trunk visceral mesoderm as a crucial founder cell-specific competence factor, in concert with the general visceral mesodermal factor Biniou. As such, it directly regulates several key genes involved in the establishment of morphogenetic centers along the anteroposterior axis of the visceral mesoderm, which subsequently organize the formation of midgut constrictions and gastric caeca and thereby determine the morphology of the midgut. Copyright © 2013 Elsevier Inc. All rights reserved.

O lúdico e o ensino de Geociências no Brasil: principais tendências das publicações na área de Ciências da Natureza

Directory of Open Access Journals (Sweden)

Danilo Missias Teixeira

2018-01-01

Full Text Available As atividades lúdicas são metodologias de ensino que vêm conquistando espaço no Ensino de Ciências; proporcionam um estudo dos conceitos de forma mais dinâmica e prazerosa. Todavia, quando se trata dos conceitos de Geociências as dificuldades apresentadas pelos professores de Ciências Exatas e Biológicas acabam por fazer com que estes profissionais não elaborem propostas vinculadas a tais conceitos. O objetivo deste trabalho é, portanto, identificar na literatura científica do Ensino de Ciências as principais tendências de pesquisas com características lúdicas que possuam como foco os conceitos de Geociências. Para isso, foi realizada uma busca em: (a banco de Teses e Dissertações da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES, e (b periódicos vinculados ao Ensino de Ciências. Como resultado, foi possível observar que as publicações lúdicas no Ensino de Ciências apresentam as seguintes tendências: (1 A maior parte das publicações tem origem na região Sudeste, principalmente nos estados de Rio de Janeiro e São Paulo; (2 O número de publicações é crescente a partir do ano de 2014, com ponto forte no ano 2016; (3 a maior área de conhecimento a apresentar trabalhos é Química, seguida de Biologia; (4 as publicações são, em sua maior parte, experiências realizadas no Ensino Médio, e (5 a modalidade lúdica preferencial é “Jogo Didático”.

The impact of founder events on chromosomal variability in multiply mating species

DEFF Research Database (Denmark)

Pool, John E; Nielsen, Rasmus

2008-01-01

size reductions and recent bottlenecks leading to decreased X/A diversity ratios. Here we use theory and simulation to investigate a separate demographic effect-that of founder events involving multiply mated females-and find that it leads to much stronger reductions in X/A diversity ratios than...

ABOUT THE FOUNDERS OF LEGAL SOCIOLOGY AND THEIR IDEAS

Directory of Open Access Journals (Sweden)

MIRELA CRISTIANA NILĂ STRATONE

2013-05-01

Full Text Available The main founders of the juridical sociology are considered to be Eugen Ehrlich, Max Weber, Theodor Geiger and Georges Gurvitch, The researches of juridical sociology from Romania are demonstrating the existence of a real tradition in this domain at a national standard. Some roumanian explores of formation jurists have practicated in the cognitive demarche a sociologycal abordation about the law, what have been fatal conduced to the fixing of the base of the juridical sociology in Romania.

Pervasive Genotypic Mosaicism in Founder Mice Derived from Genome Editing through Pronuclear Injection.

Directory of Open Access Journals (Sweden)

Daniel Oliver

Full Text Available Genome editing technologies, especially the Cas9/CRISPR system, have revolutionized biomedical research over the past several years. Generation of novel alleles has been simplified to unprecedented levels, allowing for rapid expansion of available genetic tool kits for researchers. However, the issue of genotypic mosaicism has become evident, making stringent analyses of the penetrance of genome-edited alleles essential. Here, we report that founder mice, derived from pronuclear injection of ZFNs or a mix of guidance RNAs and Cas9 mRNAs, display consistent genotypic mosaicism for both deletion and insertion alleles. To identify founders with greater possibility of transmitting the mutant allele through the germline, we developed an effective germline genotyping method. The awareness of the inherent genotypic mosaicism issue with genome editing will allow for a more efficient implementation of the technologies, and the germline genotyping method will save valuable time and resources.

MSR Founders Narrative and Content Analysis of Scholarly Papers

DEFF Research Database (Denmark)

Tackney, Charles T.; Chappell, Stacie F.; Sato, Toyoko

2017-01-01

This is a founders’ narrative and research paper content analysis of the first 15 years of the Management Spirituality and Religion Interest Group (MSR) of the Academy of Management. Based on archival data and founder interviews, our inquiry recounts how the early collaborators established......: a corpus epitomizing MSR research and practice. The combined study is a benchmark of founding and institutionalization for current and potential MSR members. By tracing the research trends MSR has taken in light of the founding aspirations, we illuminate the distinctive values, tensions, and meanings...

High prevalence of BRCA1 founder mutations in Greek breast/ovarian families.

Science.gov (United States)

Konstantopoulou, I; Tsitlaidou, M; Fostira, F; Pertesi, M; Stavropoulou, A-V; Triantafyllidou, O; Tsotra, E; Tsiftsoglou, A P; Tsionou, C; Droufakou, S; Dimitrakakis, C; Fountzilas, G; Yannoukakos, D

2014-01-01

We have screened 473 breast/ovarian cancer patients with family history, aiming to define the prevalence and enrich the spectrum of BRCA1/2 pathogenic mutations occurring in the Greek population. An overall mutation prevalence of 32% was observed. Six BRCA1 recurrent/founder mutations dominate the observed spectrum (58.5% of all mutations found). These include three mutations in exon 20 and three large genomic deletions. Of the 44 different deleterious mutations found in both genes, 16 are novel and reported here for the first time. Correlation with available histopathology data showed that 80% of BRCA1 carriers presented a triple-negative breast cancer phenotype while 82% of BRCA2 carriers had oestrogen receptor positive tumours. This study provides a comprehensive view of the frequency, type and distribution of BRCA1/2 mutations in the Greek population as well as an insight of the screening strategy of choice for patients of Greek origin. We conclude that the Greek population has a diverse mutation spectrum influenced by strong founder effects. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Publicações acadêmicas de pesquisas em contabilidade sobre terceiro setor no Brasil: análise do período de 2007 a 2009

Directory of Open Access Journals (Sweden)

Aneide Oliveira Araújo

2011-08-01

Full Text Available O desenvolvimento econômico, social e político mundial impulsionam constantes mudanças no modo de estruturar as organizações, sejam elas com fins lucrativos ou não. O Terceiro Setor tem a função de cumprir um papel social na mudança do ser humano, além realizar os serviços que o Estado não consegue cumprir. Pesquisas são realizadas em diversas áreas, no intuito de melhorar técnicas, identificar insucessos e auxiliar na tomada de decisões, dando uma visão ampla do que acontece sobre determinado setor ou tema. O problema para o desenvolvimento desta pesquisa foi qual a evolução da produção acadêmica da pesquisa contábil no Brasil, relacionada às organizações do Terceiro Setor no período de 2007 a 2009 a partir da pesquisa de Olak, Slomski e Alves, intitulada: As publicações acadêmicas da pesquisa contábil no Brasil, no âmbito das organizações do Terceiro Setor. O objetivo desta pesquisa é comparar se houve evolução acadêmica da pesquisa contábil no Brasil das organizações do Terceiro Setor de 2007 a 2009, tendo como parâmetro a pesquisa realizada entre os anos de 2000 a 2006. A metodologia utilizada foi bibliográfica e exploratória, e quanto à abordagem do problema a análise dos dados coletados é quantitativa. Após a análise dos resultados, conclui-se um aumento considerável nas publicações sobre o tema Terceiro Setor, onde foram identificados 32 trabalhos – 2007 a 2009 – enquanto que no período de 2000 a 2006 foram publicados 38 trabalhos. Tanto na pesquisa anterior como a atual ainda é inexpressivo as publicações em revistas (apenas 2 publicações.

Normas para publicação

Directory of Open Access Journals (Sweden)

Editores INTERthesis

2014-06-01

• Sociedade e Meio Ambiente Serão aceitas contribuições nas seguintes modalidades: aArtigo: deve ser original, contribuição de caráter acadêmico e/ou técnico-científico destinada a divulgar resultados de pesquisa científica, de natureza empírica, experimental ou conceitual (mínimo de 12 e máximo de 18 páginas, incluindo títulos, resumos, tabelas, figuras, mapas e referências. b Revisão: avaliação crítica sistematizada da literatura sobre determinado assunto; deve-se citar o objetivo da revisão, especificar (em métodos os critérios de busca na literatura e o universo pesquisado, discutir os resultados obtidos e sugerir estudos no sentido de preencher lacunas do conhecimento atual (mínimo de 12 e máximo de 18 páginas, incluindo títulos, resumos, tabelas, figuras, mapas e referências. cEnsaio: reflexão circunstanciada, com redação adequada ao escopo de uma publicação científica, com maior liberdade por parte do autor para defender determinada posição, que vise aprofundar a discussão ou que apresente nova contribuição/abordagem a respeito de tema relevante (mínimo de 12 e máximo de 18 páginas, incluindo títulos, resumos, tabelas, figuras, mapas e referências. d Resenha: análise crítica sobre livro publicado nos últimos dois anos (até 6 páginas, com as mesmas configurações que se solicita ao texto, incluindo referência bibliográfica completa no cabeçalho. Leia mais nas Instruções aos autores: https://periodicos.ufsc.br/index.php/interthesis/article/view/31715/25904

Citibikes de Colombia. La bicicleta publica: sistema alternativo de transporte para Santafe de Bogota

Directory of Open Access Journals (Sweden)

Javier Enrique Ramos

2000-12-01

Full Text Available EI objetivo del presente artículo es presentar una nueva propuesta en materia de transporte urbano, teniendo en cuenta el cada vez más restringido uso del automóvil particular y la ineficiencia de los actuales médicos de transporte público. En la primera parte del trabajo se presenta un panorama general de la importancia de los sistemas de transporte en las ciudades y cómo afectan la vida de sus habitantes. También se muestra la situación actual del transite en Bogotá y la necesidad de implantar sistemas alternativos de transporte. En la segunda parte, se propone el diseño de un sistema en línea de alquiler de bicicletas denominado Bicicleta Publica, que sea parte integral del Sistema integrado de transporte para Santafé de Bogotá. Para cumplir con este propósito se presentan los lineamientos generales mediante un plan de negocios, que conduzca a la creación de una empresa que administre el sistema y los servicios conexos. EI plan de negocios pretende cubrir la mayor parte de la ciudad, ubicando estaciones de bicicleta publica en diferentes lugares, principalmente en las áreas de influencia de las universidades, parques, centros comerciales y, en un futuro, en las estaciones de Transmilenio y el Metro. Esto le brinda al usuario la posibilidad de tomar una bicicleta en un punto determinado y retornarla en otra estación diferente a donde la alquiló inicialmente. Las ventajas de este mecanismo son apreciables, ya que no representa complicación alguna para el usuario debido a que puede usar la bicicleta el tiempo deseado sin preocuparse por aspectos tales como el estacionamiento, el clima o las diferentes actividades, para lo cual la bicicleta propia sería un completo inconveniente.

Rayleigh and S wave tomography constraints on subduction termination and lithospheric foundering in central California

Science.gov (United States)

Jiang, Chengxin; Schmandt, Brandon; Hansen, Steven M.; Dougherty, Sara L.; Clayton, Robert W.; Farrell, Jamie; Lin, Fan-Chi

2018-01-01

The crust and upper mantle structure of central California have been modified by subduction termination, growth of the San Andreas plate boundary fault system, and small-scale upper mantle convection since the early Miocene. Here we investigate the contributions of these processes to the creation of the Isabella Anomaly, which is a high seismic velocity volume in the upper mantle. There are two types of hypotheses for its origin. One is that it is the foundered mafic lower crust and mantle lithosphere of the southern Sierra Nevada batholith. The alternative suggests that it is a fossil slab connected to the Monterey microplate. A dense broadband seismic transect was deployed from the coast to the western Sierra Nevada to fill in the least sampled areas above the Isabella Anomaly, and regional-scale Rayleigh and S wave tomography are used to evaluate the two hypotheses. New shear velocity (Vs) tomography images a high-velocity anomaly beneath coastal California that is sub-horizontal at depths of ∼40–80 km. East of the San Andreas Fault a continuous extension of the high-velocity anomaly dips east and is located beneath the Sierra Nevada at ∼150–200 km depth. The western position of the Isabella Anomaly in the uppermost mantle is inconsistent with earlier interpretations that the Isabella Anomaly is connected to actively foundering foothills lower crust. Based on the new Vs images, we interpret that the Isabella Anomaly is not the dense destabilized root of the Sierra Nevada, but rather a remnant of Miocene subduction termination that is translating north beneath the central San Andreas Fault. Our results support the occurrence of localized lithospheric foundering beneath the high elevation eastern Sierra Nevada, where we find a lower crustal low Vs layer consistent with a small amount of partial melt. The high elevations relative to crust thickness and lower crustal low Vs zone are consistent with geological inferences that lithospheric foundering drove

Rayleigh and S wave tomography constraints on subduction termination and lithospheric foundering in central California

Science.gov (United States)

Jiang, Chengxin; Schmandt, Brandon; Hansen, Steven M.; Dougherty, Sara L.; Clayton, Robert W.; Farrell, Jamie; Lin, Fan-Chi

2018-04-01

The crust and upper mantle structure of central California have been modified by subduction termination, growth of the San Andreas plate boundary fault system, and small-scale upper mantle convection since the early Miocene. Here we investigate the contributions of these processes to the creation of the Isabella Anomaly, which is a high seismic velocity volume in the upper mantle. There are two types of hypotheses for its origin. One is that it is the foundered mafic lower crust and mantle lithosphere of the southern Sierra Nevada batholith. The alternative suggests that it is a fossil slab connected to the Monterey microplate. A dense broadband seismic transect was deployed from the coast to the western Sierra Nevada to fill in the least sampled areas above the Isabella Anomaly, and regional-scale Rayleigh and S wave tomography are used to evaluate the two hypotheses. New shear velocity (Vs) tomography images a high-velocity anomaly beneath coastal California that is sub-horizontal at depths of ∼40-80 km. East of the San Andreas Fault a continuous extension of the high-velocity anomaly dips east and is located beneath the Sierra Nevada at ∼150-200 km depth. The western position of the Isabella Anomaly in the uppermost mantle is inconsistent with earlier interpretations that the Isabella Anomaly is connected to actively foundering foothills lower crust. Based on the new Vs images, we interpret that the Isabella Anomaly is not the dense destabilized root of the Sierra Nevada, but rather a remnant of Miocene subduction termination that is translating north beneath the central San Andreas Fault. Our results support the occurrence of localized lithospheric foundering beneath the high elevation eastern Sierra Nevada, where we find a lower crustal low Vs layer consistent with a small amount of partial melt. The high elevations relative to crust thickness and lower crustal low Vs zone are consistent with geological inferences that lithospheric foundering drove uplift

How lead founder personality affects new venture performance : the mediating role of team conflict

NARCIS (Netherlands)

Jong, de A.; Song, M.; Song, L.Z.

2013-01-01

This empirical study of 323 new ventures examines how task and relationship conflict in the founding top management team mediates the effect of lead founder personality on new venture performance. The results reveal that (1) openness and agreeableness increase task conflict, whereas

How Lead Founder Personality Affects New Venture Performance: The Mediating Role of Team Conflict

NARCIS (Netherlands)

de Jong, Ad; Song, Michael; Song, Lisa Z.

2013-01-01

This empirical study of 323 new ventures examines how task and relationship conflict in the founding top management team mediates the effect of lead founder personality on new venture performance. The results reveal that (1) openness and agreeableness increase task conflict, whereas

Identification of full-length transmitted/founder viruses and their progeny in primary HIV-1 infection

Energy Technology Data Exchange (ETDEWEB)

Korber, Bette [Los Alamos National Laboratory; Hraber, Peter [Los Alamos National Laboratory; Giorgi, Elena [Los Alamos National Laboratory; Bhattacharya, T [Los Alamos National Laboratory

2009-01-01

Identification of transmitted/founder virus genomes and their progeny by is a novel strategy for probing the molecular basis of HIV-1 transmission and for evaluating the genetic imprint of viral and host factors that act to constrain or facilitate virus replication. Here, we show in a cohort of twelve acutely infected subjects (9 clade B; 3 clade C), that complete genomic sequences of transmitted/founder viruses could be inferred using single genome amplification of plasma viral RNA, direct amplicon sequencing, and a model of random virus evolution. This allowed for the precise identification, chemical synthesis, molecular cloning, and biological analysis of those viruses actually responsible for productive clinical infection and for a comprehensive mapping of sequential viral genomes and proteomes for mutations that are necessary or incidental to the establishment of HIV-1 persistence. Transmitted/founder viruses were CD4 and CCR5 tropic, replicated preferentially in activated primary T-Iymphocytes but not monocyte-derived macrophages, and were effectively shielded from most heterologous or broadly neutralizing antibodies. By 3 months of infection, the evolving viral quasispecies in three subjects showed mutational fixation at only 2-5 discreet genomic loci. By 6-12 months, mutational fixation was evident at 18-27 genomic loci. Some, but not all, of these mutations were attributable to virus escape from cytotoxic Tlymphocytes or neutralizing antibodies, suggesting that other viral or host factors may influence early HIV -1 fitness.

A serial founder effect model for human settlement out of Africa

OpenAIRE

Deshpande, Omkar; Batzoglou, Serafim; Feldman, Marcus W.; Luca Cavalli-Sforza, L.

2008-01-01

The increasing abundance of human genetic data has shown that the geographical patterns of worldwide genetic diversity are best explained by human expansion out of Africa. This expansion is modelled well by prolonged migration from a single origin in Africa with multiple subsequent serial founding events. We discuss a new simulation model for the serial founder effect out of Africa and compare it with results from previous studies. Unlike previous models, we distinguish colonization events fr...

Um modelo semântico de publicações eletrônicas | A semantic model for electronic publishing

Directory of Open Access Journals (Sweden)

Carlos Henrique Marcondes

2011-03-01

Full Text Available Resumo Publicações eletrônicas, apesar dos avanços das Tecnologias da Informação, são ainda calcados no modelo impresso. O formato textual impede que programas possam ser usados para o processamento “semântico” desses conteúdos. È porposto um modelo “semântico” de publicações cientificas eletrônicas, no qual as conclusões contidas no texto do artigo fornecidas por autores e representadas em formato “inteligível” por programas, permitindo recuperação semântica, identificação de indícios de novas descobertas científicas e de incoerências sobre este conhecimento. O modelo se baseia nos conceitos de estrutura profunda, ou semântica, da linguagem (CHOMSKY, 1975, de microestrutura, macroestrutura e superestrutura, (KINTSH, VAN DIJK, 1972, na estrutura retórica de artigos científicos (HUTCHINS, 1977, (GROSS, 1990 e nos elementos de metodologia cientifica, como problema, questão, objetivo, hipótese, experimento e conclusão. Resulta da análise de 89 artigos biomédicos. Foi desenvolvido um protótipo de sistema que implementa parcialmente o modelo. Questionários foram usados com autores para embasar o desenvolvimento do protótipo. O protótipo foi testando com pesquisadores-autores. Foram identificados quatro padrões de raciocínio e encadeamento dos elementos semânticos em artigos científicos. O modelo de conteúdo foi implementado como uma ontologia computacional. Foi desenvolvido e avaliado um protótipo de uma interface web de submissão artigos pelos autores a um sistema eletrônico de publicação de periódicos que implementa o modelo. Palavras-chave publicações eletrônicas; metodológica científica; comunicação científica; representação do conhecimento; ontologias; processamento semântico de conteúdos; e-Ciência Abstract Electronic publishing, although Information Technologies advancements, are still based in the print text model. The textual format prevents programs to semantic process

Effects of founder population size on the performance of Orius laevigatus (Hemiptera: Anthocoridae) colonies

NARCIS (Netherlands)

Castañe, C.; Bueno, V.H.P.; Carvalho, L.M.; Lenteren, van J.C.

2014-01-01

Orius laevigatus (Hemiptera: Anthocoridae) is a key predator of thrips and is mass reared in large numbers for use in biological control. The aim of this study was to evaluate the effect of founder population size on the biological and behavioral performance of O. laevigatus over time. Laboratory

O virtual e os novos paradigmas da publicação acadêmica

Directory of Open Access Journals (Sweden)

Renato Nunes Bittencourt

2012-02-01

Full Text Available O presente artigo analisa as vantagens técnicas das publicações acadêmicas realizadas pelo suporte virtual, em decorrência da dinamicidade das interações intelectuais próprias da dimensão da Internet. Através do enfoque teórico de Pierre Lévy, um dos principais filósofos da dita “Cibercultura”, apresentamos as mudanças de perspectivas epistemológicas operadas pela difusão planetária da Internet e de que maneira tal transformação influenciou no processo de editoração dos periódicos acadêmicos, envolvendo de forma mais precisa a participação plena da comunidade intelectual em torno do processo de realização do veículo de difusão de conhecimento.

A qualidade das publicações científicas: considerações de um Editor de Área ao final do mandato Quality of scientific puplications: considerations of an editor at the end of the mandate

OpenAIRE

Ulysses Paulino de Albuquerque

2009-01-01

A qualidade das publicações científicas vem sendo discutida na atualidade considerando diferentes perspectivas. Neste texto, examina-se alguns dos principais problemas relativos à produção textual em ciência, com ênfase para os considerados de má conduta. Adicionalmente, são apresentadas sugestões para autores, revisores e editores no sentido de evitar condutas inadequadas no processo de publicação de trabalhos científicos.Quality of scientific publications is being currently discussed consid...

Quentin Skinner, Staten og friheten. Oslo: Res Publica, 2011. José Luis Martí and Philip Pettit, A Political Philosophy in Public Life. Civic Republicanism in Zapatero's Spain. Princeton: Princeton University Press, 2010 (Simon Laumann Jørgensen)

DEFF Research Database (Denmark)

Jørgensen, Simon Laumann

2012-01-01

Anmeldelse af Quentin Skinner, Staten og friheten, Oslo: Res Publica 2011, 199 NOK & José Luis Martí & Philip Pettit, A Political Philosophy in Public Life. Civic Republicanism in Zapatero’s Spain, Princeton: Princeton University Press 2010, $ 24.95......Anmeldelse af Quentin Skinner, Staten og friheten, Oslo: Res Publica 2011, 199 NOK & José Luis Martí & Philip Pettit, A Political Philosophy in Public Life. Civic Republicanism in Zapatero’s Spain, Princeton: Princeton University Press 2010, $ 24.95...

Founder takes all: density-dependent processes structure biodiversity.

Science.gov (United States)

Waters, Jonathan M; Fraser, Ceridwen I; Hewitt, Godfrey M

2013-02-01

Density-dependent processes play a key role in the spatial structuring of biodiversity. Specifically, interrelated demographic processes, such as gene surfing, high-density blocking, and competitive exclusion, can generate striking geographic contrasts in the distributions of genes and species. Here, we propose that well-studied evolutionary and ecological biogeographic patterns of postglacial recolonization, progressive island colonization, microbial sectoring, and even the 'Out of Africa' pattern of human expansion, are fundamentally similar, underpinned by a 'founder takes all' density-dependent principle. Additionally, we hypothesize that older historic constraints of density-dependent processes are seen today in the dramatic biogeographic shifts that occur in response to human-mediated extinction events, whereby surviving lineages rapidly expand their ranges to replace extinct sister taxa. Copyright © 2012 Elsevier Ltd. All rights reserved.

Can a linguistic serial founder effect originating in Africa explain the worldwide phonemic cline?

Science.gov (United States)

Fort, Joaquim; Pérez-Losada, Joaquim

2016-04-01

It has been proposed that a serial founder effect could have caused the present observed pattern of global phonemic diversity. Here we present a model that simulates the human range expansion out of Africa and the subsequent spatial linguistic dynamics until today. It does not assume copying errors, Darwinian competition, reduced contrastive possibilities or any other specific linguistic mechanism. We show that the decrease of linguistic diversity with distance (from the presumed origin of the expansion) arises under three assumptions, previously introduced by other authors: (i) an accumulation rate for phonemes; (ii) small phonemic inventories for the languages spoken before the out-of-Africa dispersal; (iii) an increase in the phonemic accumulation rate with the number of speakers per unit area. Numerical simulations show that the predictions of the model agree with the observed decrease of linguistic diversity with increasing distance from the most likely origin of the out-of-Africa dispersal. Thus, the proposal that a serial founder effect could have caused the present observed pattern of global phonemic diversity is viable, if three strong assumptions are satisfied. © 2016 The Authors.

Can a linguistic serial founder effect originating in Africa explain the worldwide phonemic cline?

Science.gov (United States)

2016-01-01

It has been proposed that a serial founder effect could have caused the present observed pattern of global phonemic diversity. Here we present a model that simulates the human range expansion out of Africa and the subsequent spatial linguistic dynamics until today. It does not assume copying errors, Darwinian competition, reduced contrastive possibilities or any other specific linguistic mechanism. We show that the decrease of linguistic diversity with distance (from the presumed origin of the expansion) arises under three assumptions, previously introduced by other authors: (i) an accumulation rate for phonemes; (ii) small phonemic inventories for the languages spoken before the out-of-Africa dispersal; (iii) an increase in the phonemic accumulation rate with the number of speakers per unit area. Numerical simulations show that the predictions of the model agree with the observed decrease of linguistic diversity with increasing distance from the most likely origin of the out-of-Africa dispersal. Thus, the proposal that a serial founder effect could have caused the present observed pattern of global phonemic diversity is viable, if three strong assumptions are satisfied. PMID:27122180

Linkage disequilibrium analysis in young populations: Pseudo-vitamin D-deficiency rickets and the founder effect in French Canadians

Energy Technology Data Exchange (ETDEWEB)

Labuda, M.; Glorieux, F.H. [McGill Univ., Montreal (Canada); Labuda, D.; Korab-Laskowska, M. [Universite de Montreal (Canada)] [and others

1996-09-01

Pseudo-vitamin D-deficiency rickets (PDDR) was mapped close to D12S90 and between proximal D12S312 and distal (D12S305, D12S104) microsatellites that were subsequently found on a single YAC clone. Analysis of a complex haplotype in linkage disequilibrium (LD) with the disease discriminated among distinct founder effects in French Canadian populations in Acadia and in Charlevoix-Saguenay-Lac-Saint-Jean (Ch-SLSJ), as well as an earlier one in precolonial Europe. A simple demographic model suggested the historical age of the founder effect in Ch-SLSJ to be {approximately}12 generations. The corresponding LD data are consistent with this figure when they are analyzed within the framework of Luria-Delbruck model, which takes into account the population growth. Population sampling due to a limited number of first settlers and the rapid demographic expansion appear to have played a major role in the founding of PDDR in Ch-SLSJ and, presumably, other genetic disorders endemic to French Canada. Similarly, the founder effect in Ashkenazim, coinciding with their early settlement in medieval Poland and subsequent expansion eastward, could explain the origin of frequent genetic diseases in this population. 48 refs., 5 figs., 2 tabs.

Signatures of seaway closures and founder dispersal in the phylogeny of a circumglobally distributed seahorse lineage.

Science.gov (United States)

Teske, Peter R; Hamilton, Healy; Matthee, Conrad A; Barker, Nigel P

2007-08-15

The importance of vicariance events on the establishment of phylogeographic patterns in the marine environment is well documented, and generally accepted as an important cause of cladogenesis. Founder dispersal (i.e. long-distance dispersal followed by founder effect speciation) is also frequently invoked as a cause of genetic divergence among lineages, but its role has long been challenged by vicariance biogeographers. Founder dispersal is likely to be common in species that colonize remote habitats by means of rafting (e.g. seahorses), as long-distance dispersal events are likely to be rare and subsequent additional recruitment from the source habitat is unlikely. In the present study, the relative importance of vicariance and founder dispersal as causes of cladogenesis in a circumglobally distributed seahorse lineage was investigated using molecular dating. A phylogeny was reconstructed using sequence data from mitochondrial and nuclear markers, and the well-documented closure of the Central American seaway was used as a primary calibration point to test whether other bifurcations in the phylogeny could also have been the result of vicariance events. The feasibility of three other vicariance events was explored: a) the closure of the Indonesian Seaway, resulting in sister lineages associated with the Indian Ocean and West Pacific, respectively; b) the closure of the Tethyan Seaway, resulting in sister lineages associated with the Indo-Pacific and Atlantic Ocean, respectively, and c) continental break-up during the Mesozoic followed by spreading of the Atlantic Ocean, resulting in pairs of lineages with amphi-Atlantic distribution patterns. Comparisons of pairwise genetic distances among the seahorse species hypothesized to have diverged as a result of the closure of the Central American Seaway with those of published teleost sequences having the same distribution patterns show that the seahorses were among the last to diverge. This suggests that their

Signatures of seaway closures and founder dispersal in the phylogeny of a circumglobally distributed seahorse lineage

Directory of Open Access Journals (Sweden)

Matthee Conrad A

2007-08-01

Full Text Available Abstract Background The importance of vicariance events on the establishment of phylogeographic patterns in the marine environment is well documented, and generally accepted as an important cause of cladogenesis. Founder dispersal (i.e. long-distance dispersal followed by founder effect speciation is also frequently invoked as a cause of genetic divergence among lineages, but its role has long been challenged by vicariance biogeographers. Founder dispersal is likely to be common in species that colonize remote habitats by means of rafting (e.g. seahorses, as long-distance dispersal events are likely to be rare and subsequent additional recruitment from the source habitat is unlikely. In the present study, the relative importance of vicariance and founder dispersal as causes of cladogenesis in a circumglobally distributed seahorse lineage was investigated using molecular dating. A phylogeny was reconstructed using sequence data from mitochondrial and nuclear markers, and the well-documented closure of the Central American seaway was used as a primary calibration point to test whether other bifurcations in the phylogeny could also have been the result of vicariance events. The feasibility of three other vicariance events was explored: a the closure of the Indonesian Seaway, resulting in sister lineages associated with the Indian Ocean and West Pacific, respectively; b the closure of the Tethyan Seaway, resulting in sister lineages associated with the Indo-Pacific and Atlantic Ocean, respectively, and c continental break-up during the Mesozoic followed by spreading of the Atlantic Ocean, resulting in pairs of lineages with amphi-Atlantic distribution patterns. Results Comparisons of pairwise genetic distances among the seahorse species hypothesized to have diverged as a result of the closure of the Central American Seaway with those of published teleost sequences having the same distribution patterns show that the seahorses were among the last to

Fomento à publicação científica e proteção do conhecimento científico Financing of the scientific publication and protection of the scientific knowledge

Directory of Open Access Journals (Sweden)

Renato Santos de Oliveira Filho

2005-01-01

Full Text Available O trabalho científico atinge sua finalidade maior através de sua publicação. É indiscutível a importância atual das agências de fomento à pesquisa para que se possa desenvolver, finalizar e publicar os trabalhos científicos. As principais agências de fomento abordadas neste artigo são: a Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES, o Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq e a Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP. As atividades da CAPES podem ser agrupadas em quatro grandes linhas de ação: a avaliação da pós-graduação stricto sensu; b acesso e divulgação da produção científica; c investimentos na formação de recursos de alto nível no país e exterior e d promoção da cooperação científica internacional. Embora não haja uma linha direta de apoio à publicação científica, praticamente todas as ações da CAPES acabam por contribuir para a concretização de trabalhos científicos e suas publicações. O CNPq tem duas atividades básicas: o fomento à pesquisa e a formação de recursos humanos. Disponibiliza aos pesquisadores auxílio à divulgação e publicação científicas. O auxílio à editoração tem como objetivo apoiar publicações técnico-científicas nacionais, mantidas e editadas por instituição ou sociedade científica brasileira de âmbito nacional. Através do auxílio à promoção de eventos científicos, o CNPq apóia realização no país de congressos, simpósios e outros eventos similares de curta duração. O CNPq disponibiliza a Plataforma Lattes através da qual é possível preencher e acessar o Curriculum Lattes, hoje indispensável aos pesquisadores. A FAPESP financia publicação de periódicos, artigos e livros que exponham resultados originais de pesquisa realizada por pesquisador do Estado de São Paulo. Financia parcialmente a participação de pesquisadores em reuniões científicas ou

Constitutional Mismatch Repair Deficiency in Israel: High Proportion of Founder Mutations in MMR Genes and Consanguinity.

Science.gov (United States)

Baris, Hagit N; Barnes-Kedar, Inbal; Toledano, Helen; Halpern, Marisa; Hershkovitz, Dov; Lossos, Alexander; Lerer, Israela; Peretz, Tamar; Kariv, Revital; Cohen, Shlomi; Half, Elizabeth E; Magal, Nurit; Drasinover, Valerie; Wimmer, Katharina; Goldberg, Yael; Bercovich, Dani; Levi, Zohar

2016-03-01

Heterozygous germline mutations in any of the mismatch repair (MMR) genes, MLH1, MSH2, MSH6, and PMS2, cause Lynch syndrome (LS), an autosomal dominant cancer predisposition syndrome conferring a high risk of colorectal, endometrial, and other cancers in adulthood. Offspring of couples where both spouses have LS have a 1:4 risk of inheriting biallelic MMR gene mutations. These cause constitutional MMR deficiency (CMMRD) syndrome, a severe recessively inherited cancer syndrome with a broad tumor spectrum including mainly hematological malignancies, brain tumors, and colon cancer in childhood and adolescence. Many CMMRD children also present with café au lait spots and axillary freckling mimicking neurofibromatosis type 1. We describe our experience in seven CMMRD families demonstrating the role and importance of founder mutations and consanguinity on its prevalence. Clinical presentations included brain tumors, colon cancer, lymphoma, and small bowel cancer. In children from two nonconsanguineous Ashkenazi Jewish (AJ) families, the common Ashkenazi founder mutations were detected; these were homozygous in one family and compound heterozygous in the other. In four consanguineous families of various ancestries, different homozygous mutations were identified. In a nonconsanguineous Caucasus/AJ family, lack of PMS2 was demonstrated in tumor and normal tissues; however, mutations were not identified. CMMRD is rare, but, especially in areas where founder mutations for LS and consanguinity are common, pediatricians should be aware of it since they are the first to encounter these children. Early diagnosis will enable tailored cancer surveillance in the entire family and a discussion regarding prenatal genetic diagnosis. © 2015 Wiley Periodicals, Inc.

13 February 2012 - World Economic Forum Founder and Executive Chairman K. Schwab and Chairperson and Co-Founder Schwab Foundation for Social Entrepreneurship H. Schwab (Mrs)in the ATLAS experimental area at LHC Point 1 with Collaboration Former Spokesperson P. Jenni; signing the guest book with CERN Director-General R. Heuer and Head of International Relations F. Pauss.

CERN Multimedia

Jean-Claude Gadmer

2012-01-01

13 February 2012 - World Economic Forum Founder and Executive Chairman K. Schwab and Chairperson and Co-Founder Schwab Foundation for Social Entrepreneurship H. Schwab (Mrs)in the ATLAS experimental area at LHC Point 1 with Collaboration Former Spokesperson P. Jenni; signing the guest book with CERN Director-General R. Heuer and Head of International Relations F. Pauss.

Elon Musk, founder of SpaceX and PayPal, to speak on campus Feb. 21

OpenAIRE

Crumbley, Liz

2006-01-01

Elon Musk, founder and chief executive officer of Space Exploration Technologies Co. (SpaceX), will speak on his company's Falcon rocket series and the future of university space research on Tuesday, Feb. 21 at 7:30 p.m. in Virginia Tech's Burruss Hall Auditorium. The event is free and open to the public.

Ética na publicação de pesquisas sobre leishmaniose visceral humana em periódicos nacionais

OpenAIRE

Malafaia, Guilherme; Rodrigues, Aline Sueli de Lima; Talvani, André

2010-01-01

OBJETIVO: Analisar os aspectos éticos dos artigos nacionais sobre leishmaniose visceral humana publicados após a Resolução CNS 196/1996 e analisar a política de periódicos brasileiros sobre ética em pesquisa. MÉTODOS: Estudo exploratório de natureza bibliográfica e documental. A seleção das publicações sobre pesquisas envolvendo seres humanos foi realizada na base SciELO Brasil a partir de 1996. Foram analisadas lacunas relacionadas às políticas editoriais dos periódicos médicos a partir de i...

Haplotype variation in founders of the Mauremys annamensis population kept in European Zoos

Directory of Open Access Journals (Sweden)

Barbora Somerova

2015-06-01

Full Text Available The critically endangered Annam leaf turtle Mauremys annamensis faces extinction in nature. Because of that, the conservation value of the population kept in European zoos becomes substantial for reintroduction programmes. We sampled 39 specimens of M. annamensis from European zoos and other collections (mainly founders, imports and putatively unrelated individuals, and also four specimens of Mauremys mutica for comparison. In each animal, we sequenced 817 bp of the mitochondrial ND4 gene and 940 bp of the nuclear R35 intron that were used as phylogenetic markers for Mauremys mutica-annamensis group by previous authors. The sequences of the R35 intron, which are characteristic for M. annamensis and which clearly differ from those characteristic for M. mutica and/or other Mauremys species, were mutually shared by all of the examined M. annamensis. They also possessed mitochondrial haplotypes belonging to the annamensis subclades I and II, distinctness of which was clearly confirmed by phylogenetic analyses. Thus, both nuclear and mitochondrial markers agreed in the unequivocal assignment of the examined individuals to M. annamensis. Although no obvious hybrids were detected within the founders of the captive population, further careful genetic evaluation using genom-wide markers is required to unequivocally confirm this result.

Fatores de impacto de publicações psiquiátricas e produtividade científica

Directory of Open Access Journals (Sweden)

Elkis Helio

1999-01-01

Full Text Available OBJETIVO: Mostrar que alguns índices bibliométricos, como o Fator de Impacto (FI e a análise de citações, são úteis para avaliação da repercussão científica de publicações psiquiátricas. Tais índices podem também ser empregados na avaliação de produtividade científica individual. MÉTODOS: Os fatores de impacto de periódicos psiquiátricos dos anos de 1995 e 1997 foram obtidos através do "Journal of Citation Reports". As curvas de distribuição foram analisadas através de histogramas e gráficos tipo caixa (box-plots. As médias das avaliações de 1995 e 1997 foram comparadas através do teste de soma de postos de Wilcoxon. RESULTADOS: As curvas de distribuição dos fatores de impacto em 1995 e 1997 mostraram não obedecer a uma distribuição normal. A média de ambas as avaliações girou em torno de 1,5. Houve um aumento significativo na média dos fatores de impacto de 1995 para 1997 ( Wilcoxon W=57 p=0,026. Três periódicos mantiveram os seus fatores de impacto várias vezes acima da média geral em ambas as avaliações ("outliers": "Archives of General Psychiatry", "American Journal of Psychiatry" e "Journal of Clinical Psychopharmacology". CONCLUSÕES: Os fatores de impacto são os melhores índices para avaliação do desempenho científico de publicações psiquiátricas. No entanto, no caso de avaliações da produtividade científica individual, esta também deve ser avaliada através de uma análise de citações.

Ethical dilemmas in scientific publication: pitfalls and solutions for editors Dilemas éticos na publicação científica: dificuldades e soluções para editores

Directory of Open Access Journals (Sweden)

Laragh Gollogly

2006-08-01

Full Text Available Editors of scientific journals need to be conversant with the mechanisms by which scientific misconduct is amplified by publication practices. This paper provides definitions, ways to document the extent of the problem, and examples of editorial attempts to counter fraud. Fabrication, falsification, duplication, ghost authorship, gift authorship, lack of ethics approval, non-disclosure, 'salami' publication, conflicts of interest, auto-citation, duplicate submission, duplicate publications, and plagiarism are common problems. Editorial misconduct includes failure to observe due process, undue delay in reaching decisions and communicating these to authors, inappropriate review procedures, and confounding a journal's content with its advertising or promotional potential. Editors also can be admonished by their peers for failure to investigate suspected misconduct, failure to retract when indicated, and failure to abide voluntarily by the six main sources of relevant international guidelines on research, its reporting and editorial practice. Editors are in a good position to promulgate reasonable standards of practice, and can start by using consensus guidelines on publication ethics to state explicitly how their journals function. Reviewers, editors, authors and readers all then have a better chance to understand, and abide by, the rules of publishing.Editores de revistas científicas precisam estar atentos aos mecanismos de disseminação de condutas inadequadas no processo de publicação. Este artigo fornece definições, formas de documentar a extensão do problema e exemplos de iniciativas para conter fraudes editorias. Fabricação, falsificação, duplicação, autoria-fantasma, autoria concedida, falta de ética na aprovação de manuscritos, não-divulgação desses fatos, publicação "salami", conflitos de interesse, autocitação, submissão e publicação duplicadas, e plágio são problemas comuns. A conduta editorial inadequada

PRIMAL: Fast and accurate pedigree-based imputation from sequence data in a founder population.

Directory of Open Access Journals (Sweden)

Oren E Livne

2015-03-01

Full Text Available Founder populations and large pedigrees offer many well-known advantages for genetic mapping studies, including cost-efficient study designs. Here, we describe PRIMAL (PedigRee IMputation ALgorithm, a fast and accurate pedigree-based phasing and imputation algorithm for founder populations. PRIMAL incorporates both existing and original ideas, such as a novel indexing strategy of Identity-By-Descent (IBD segments based on clique graphs. We were able to impute the genomes of 1,317 South Dakota Hutterites, who had genome-wide genotypes for ~300,000 common single nucleotide variants (SNVs, from 98 whole genome sequences. Using a combination of pedigree-based and LD-based imputation, we were able to assign 87% of genotypes with >99% accuracy over the full range of allele frequencies. Using the IBD cliques we were also able to infer the parental origin of 83% of alleles, and genotypes of deceased recent ancestors for whom no genotype information was available. This imputed data set will enable us to better study the relative contribution of rare and common variants on human phenotypes, as well as parental origin effect of disease risk alleles in >1,000 individuals at minimal cost.

Zdess dõshite, zdess ne dõshite / Lidia Iljina

Index Scriptorium Estoniae

Iljina, Lidia

2006-01-01

Tuntud politoloog Rein Taagepera tegi ettepaneku, et presidendikandidaadid läbiksid kohustuslikus korras arstliku läbivaatluse. Arvamused Toivo Tootsenilt, Liina Tõnissonilt ja psühholoog Jüri Ennetilt

Kümnendikku riigikogust seovad peresidemed / Rein Sikk

Index Scriptorium Estoniae

Sikk, Rein, 1961-

2007-01-01

Vastvalitud riigikogus seovad kahtteist liiget perekondlikud sidemed. Vt. samas: Kas onupojapoliitika või juhus? Kommenteerivad: politoloog Rein Toomla, TÜ professor Marju Lauristin, TLÜ professor Rein Ruutsoo, emeriitprofessor Rein Taagepera

Huvilised sukeldusid nahkhiirte maailma / Vello Jaska

Index Scriptorium Estoniae

Jaska, Vello, 1949-

2012-01-01

Taageperas Kivimäe turismitalus toimunud looduslaagris rääkis nahkhiirtest Tallinna Ülikooli lektor, MTÜ Suurkõrv spetsialist Triinu Tõrv, looduslaagri korraldas Ala põhikooli õpetaja Evelyn Tamm

Cicero and the Mixed Constitution (res publica mixta

Directory of Open Access Journals (Sweden)

Mitja Sadek

2009-12-01

Full Text Available The story of the mixed constitution is the story of the most stable and just constitution. In theory, this is a combination of at least two of the three elementary forms of government (monarchy, aristocracy and democracy, with some advantages that elementary forms may lack. It originated with the deliberation of Greek philosophers, who wanted to draw up a constitution safeguarding against the permanent variation of elementary constitutional forms and against coups d’état. For both Plato and Aristotle, the mixed constitution was, above all, the reflection of a search for balance between the two extreme forms of government, direct (Athenian democracy on the one hand and the exclusion of the people from governing on the other. The Greek theory was applied by the historian Polybius to the traditional tripartite constitution of the Roman republic. In his view, the consuls were monarchic elements, the senate an aristocratic element, and the comitia a democratic one. Cicero’s introduction of the idea of the mixed constitution in De re publica can only be understood in the light of the author’s personal situation and contemporary political circumstances. His political engagement at a time when the republic was gradually transforming into a monarchy aimed at restoring the important role of the nobility, represented by the senate. For Cicero, the mixed constitution was mainly an instrument for restoring the lost balance between the consuls, the senate, and the comitia, a last chance to save the decaying republic. The concluding part of the article addresses Alois Riklin’s recent discussion of the modern reception of the mixed constitution idea, which advances the controversial thesis that the paradigm of power division, the foundation of modern representative democracy, originates directly from the mixed constitution.

Percecao da cultura organizacional em instituicoes publicas de saude com diferentes modelos de gestao Percepcion de la cultura organizacional en las instituciones de salud publica con diferentes modelos de gestion Perception of organizational culture in public health facilities with different management models

Directory of Open Access Journals (Sweden)

Sofia Gaspar Cruz

2012-03-01

Full Text Available Contexto: o sistema de saude portugues tem vindo a ser palco de reformas constantes sem que se tenham obtido os resultados esperados. Considerada enquanto variavel organizacional, que pode ditar o sucesso de determinada mudanca/reforma, e partindo-se do pressuposto que e gerivel, conhecer a cultura organizacional que predomina nas instituicoes de saude parece ser importante para quem as gere, principalmente perante processos de mudanca, como seja a implementacao de novos modelos de gestao. Objetivo: identificar o tipo de cultura organizacional que predomina em instituicoes publicas de saude com diferentes modelos de gestao. Metodo: estudo de tipo quantitativo e transversal, realizado numa amostra de 671 colaboradores de dez instituicoes de saude com diferentes modelos de gestao: modelo Sector Publico Administrativo (SPA, modelo Entidade Publica Empresarial (EPE e modelo Unidade de Saude Familiar (USF. Para identificar a percecao da cultura organizacional recorreu-se ao Organizational Culture Assessment Instrument (OCAI, que foi por nos traduzido, adaptado e validado. Resultados: nos modelos SPA e EPE verifica-se um predominio da cultura hierarquica, enquanto no modelo USF sobressai a cultura de cla. Conclusao: a cultura organizacional que prevalece nas instituicoes de saude, nomeadamente a nivel hospitalar (cultura hierarquica, nao parece ser a mais adequada a filosofia subjacente aos novos modelos de gestao e seu funcionamento. Considera-se pertinente alargar o estudo da percecao da cultura organizacional em cada modelo de gestao das instituicoes de saude e relacionar com variaveis de contexto.Contexto: el sistema de salud portugues ha sido el escenario de constantes reformas sin que por ello se hayan obtenido los resultados esperados. Considerada como una variable organizacional, que puede dictar el exito de un determinado cambio o reforma, y partiendo de la suposicion de que es gestionable, conocer la cultura organizacional que predomina en

"Mõisaromantika" jätkub Tõstamaa mõisakoolis / Silja Joon

Index Scriptorium Estoniae

Joon, Silja, 1966-

2006-01-01

Kontsertidest sarja "Mõisaromantika" raames: "Võrratu klavessiin" 28. okt. Tõstamaa mõisakoolis (barokkansambel Corelli Consort), nov. lõpul "Jõulud mõisas" Taagepera lossis ja Vihterpalu mõisas (jazztrio Tafenau-Vind-Padilla), esinejatest

Identification of novel BRCA founder mutations in Middle Eastern breast cancer patients using capture and Sanger sequencing analysis.

Science.gov (United States)

Bu, Rong; Siraj, Abdul K; Al-Obaisi, Khadija A S; Beg, Shaham; Al Hazmi, Mohsen; Ajarim, Dahish; Tulbah, Asma; Al-Dayel, Fouad; Al-Kuraya, Khawla S

2016-09-01

Ethnic differences of breast cancer genomics have prompted us to investigate the spectra of BRCA1 and BRCA2 mutations in different populations. The prevalence and effect of BRCA 1 and BRCA 2 mutations in Middle Eastern population is not fully explored. To characterize the prevalence of BRCA mutations in Middle Eastern breast cancer patients, BRCA mutation screening was performed in 818 unselected breast cancer patients using Capture and/or Sanger sequencing. 19 short tandem repeat (STR) markers were used for founder mutation analysis. In our study, nine different types of deleterious mutation were identified in 28 (3.4%) cases, 25 (89.3%) cases in BRCA 1 and 3 (10.7%) cases in BRCA 2. Seven recurrent mutations identified accounted for 92.9% (26/28) of all the mutant cases. Haplotype analysis was performed to confirm c.1140 dupG and c.4136_4137delCT mutations as novel putative founder mutation, accounting for 46.4% (13/28) of all BRCA mutant cases and 1.6% (13/818) of all the breast cancer cases, respectively. Moreover, BRCA 1 mutation was significantly associated with BRCA 1 protein expression loss (p = 0.0005). Our finding revealed that a substantial number of BRCA mutations were identified in clinically high risk breast cancer from Middle East region. Identification of the mutation spectrum, prevalence and founder effect in Middle Eastern population facilitates genetic counseling, risk assessment and development of cost-effective screening strategy. © 2016 UICC.

The first Dutch SDHB founder deletion in paraganglioma – pheochromocytoma patients

Directory of Open Access Journals (Sweden)

Devilee Peter

2009-04-01

Full Text Available Abstract Background Germline mutations of the tumor suppressor genes SDHB, SDHC and SDHD play a major role in hereditary paraganglioma and pheochromocytoma. These three genes encode subunits of succinate dehydrogenase (SDH, the mitochondrial tricarboxylic acid cycle enzyme and complex II component of the electron transport chain. The majority of variants of the SDH genes are missense and nonsense mutations. To date few large deletions of the SDH genes have been described. Methods We carried out gene deletion scanning using MLPA in 126 patients negative for point mutations in the SDH genes. We then proceeded to the molecular characterization of deletions, mapping breakpoints in each patient and used haplotype analysis to determine whether the deletions are due to a mutation hotspot or if a common haplotype indicated a single founder mutation. Results A novel deletion of exon 3 of the SDHB gene was identified in nine apparently unrelated Dutch patients. An identical 7905 bp deletion, c.201-4429_287-933del, was found in all patients, resulting in a frameshift and a predicted truncated protein, p.Cys68HisfsX21. Haplotype analysis demonstrated a common haplotype at the SDHB locus. Index patients presented with pheochromocytoma, extra-adrenal PGL and HN-PGL. A lack of family history was seen in seven of the nine cases. Conclusion The identical exon 3 deletions and common haplotype in nine patients indicates that this mutation is the first Dutch SDHB founder mutation. The predominantly non-familial presentation of these patients strongly suggests reduced penetrance. In this small series HN-PGL occurs as frequently as pheochromocytoma and extra-adrenal PGL.

Congenital sucrase-isomaltase deficiency: identification of a common Inuit founder mutation.

Science.gov (United States)

Marcadier, Julien L; Boland, Margaret; Scott, C Ronald; Issa, Kheirie; Wu, Zaining; McIntyre, Adam D; Hegele, Robert A; Geraghty, Michael T; Lines, Matthew A

2015-02-03

Congenital sucrase-isomaltase deficiency is a rare hereditary cause of chronic diarrhea in children. People with this condition lack the intestinal brush-border enzyme required for digestion of di- and oligosaccharides, including sucrose and isomaltose, leading to malabsorption. Although the condition is known to be highly prevalent (about 5%-10%) in several Inuit populations, the genetic basis for this has not been described. We sought to identify a common mutation for congenital sucrase-isomaltase deficiency in the Inuit population. We sequenced the sucrase-isomaltase gene, SI, in a single Inuit proband with congenital sucrase-isomaltase deficiency who had severe fermentative diarrhea and failure to thrive. We then genotyped a further 128 anonymized Inuit controls from a variety of locales in the Canadian Arctic to assess for a possible founder effect. In the proband, we identified a novel, homozygous frameshift mutation, c.273_274delAG (p.Gly92Leufs*8), predicted to result in complete absence of a functional protein product. This change was very common among the Inuit controls, with an observed allele frequency of 17.2% (95% confidence interval [CI] 12.6%-21.8%). The predicted Hardy-Weinberg prevalence of congenital sucrase-isomaltase deficiency in Inuit people, based on this single founder allele, is 3.0% (95% CI 1.4%-4.5%), which is comparable with previous estimates. We found a common mutation, SI c.273_274delAG, to be responsible for the high prevalence of congenital sucrase-isomaltase deficiency among Inuit people. Targeted mutation testing for this allele should afford a simple and minimally invasive means of diagnosing this condition in Inuit patients with chronic diarrhea. © 2015 Canadian Medical Association or its licensors.

Founder effect of the RET C611Y mutation in multiple endocrine neoplasia 2A in Denmark

DEFF Research Database (Denmark)

Mathiesen, Jes Sloth; Kroustrup, Jens Peter; Vestergaard, Peter

2017-01-01

BACKGROUND: Multiple endocrine neoplasia (MEN) 2A and 2B are caused by REarranged during Transfection (RET) germline mutations. In a recent nationwide study we reported of an unusually high prevalence (33%) of families with the C611Y mutation and hypothesized that this might be due to a founder...... effect. We conducted the first nationwide study of haplotypes in MEN2A families aiming to investigate the relatedness and occurrence of de novo mutations among Danish families carrying similar mutations. METHODS: The study included 21 apparently unrelated MEN2A families identified from a nationwide...... Danish RET cohort from 1994 to 2014. Twelve, two, two, three and two families carried the C611Y, C618F, C618Y, C620R and C634R mutation, respectively. Single nucleotide polymorphism chip data and identity by descent analysis were used to assess relatedness. RESULTS: A common founder mutation was found...

Anneli Remme soovitab : Kammerdžässi kava "Jõulud mõisas" / Siim Nestor

Index Scriptorium Estoniae

Nestor, Siim, 1974-

2006-01-01

Eesti-Tšiili trio Raivo Tafenau - Meelis Vind - Ricardo Padilla kontsertidest sarja "Mõisaromantika" raames 25. nov. Taagepera lossis Valgamaal, 26. nov. Tõstamaa mõisas Pärnumaal ja 16. dets. Vihterpalu mõisas Harjumaal

Apple founder targets healthcare as NeXT market. Interview by Carolyn Dunbar and Michael L. Laughlin.

Science.gov (United States)

Jobs, S

1992-12-01

Cofounder and former chairman of the board of Apple Computer Steven Jobs looks beyond the 1980s image of a petulant, embittered young man, fighting with all who failed to share his vision, and many who did. Today, as a founder, president and chairman of NeXT, Inc., he looks to more high-minded applications of his computer genius.

"Founder crops" v. wild plants: Assessing the plant-based diet of the last hunter-gatherers in southwest Asia

Science.gov (United States)

Arranz-Otaegui, Amaia; González Carretero, Lara; Roe, Joe; Richter, Tobias

2018-04-01

The Natufian culture (c. 14.6-11.5 ka cal. BP) represents the last hunter-gatherer society that inhabited southwest Asia before the development of plant food production. It has long been suggested that Natufians based their economy on the exploitation of the wild ancestors of the Neolithic "founder crops", and that these hunter-gatherers were therefore on the "threshold to agriculture". In this work we review the available data on Natufian plant exploitation and we report new archaeobotanical evidence from Shubayqa 1, a Natufian site located in northeastern Jordan (14.6-11.5 ka cal. BP). Shubayqa 1 has produced an exceptionally large plant assemblage, including direct evidence for the continuous exploitation of club-rush tubers (often regarded as "missing foods") and other wild plants, which were probably used as food, fuel and building materials. Taking together this data we evaluate the composition of archaeobotanical assemblages (plant macroremains) from the Natufian to the Early Pre-Pottery Neolithic B (EPPNB). Natufian assemblages comprise large proportions of non-founder plant species (>90% on average), amongst which sedges, small-seeded grasses and legumes, and fruits and nuts predominate. During the Pre-Pottery Neolithic, in particular the EPPNB, the presence of "founder crops" increases dramatically and constitute up to c. 42% of the archaeobotanical assemblages on average. Our results suggest that plant exploitation strategies during the Natufian were very different from those attested during subsequent Neolithic periods. We argue that historically driven interpretations of the archaeological record have over-emphasized the role of the wild ancestors of domesticated crops previous to the emergence of agriculture.

The Expression of TALEN before Fertilization Provides a Rapid Knock-Out Phenotype in Xenopus laevis Founder Embryos.

Science.gov (United States)

Miyamoto, Kei; Suzuki, Ken-Ichi T; Suzuki, Miyuki; Sakane, Yuto; Sakuma, Tetsushi; Herberg, Sarah; Simeone, Angela; Simpson, David; Jullien, Jerome; Yamamoto, Takashi; Gurdon, J B

2015-01-01

Recent advances in genome editing using programmable nucleases have revolutionized gene targeting in various organisms. Successful gene knock-out has been shown in Xenopus, a widely used model organism, although a system enabling less mosaic knock-out in founder embryos (F0) needs to be explored in order to judge phenotypes in the F0 generation. Here, we injected modified highly active transcription activator-like effector nuclease (TALEN) mRNA to oocytes at the germinal vesicle (GV) stage, followed by in vitro maturation and intracytoplasmic sperm injection, to achieve a full knock-out in F0 embryos. Unlike conventional injection methods to fertilized embryos, the injection of TALEN mRNA into GV oocytes allows expression of nucleases before fertilization, enabling them to work from an earlier stage. Using this procedure, most of developed embryos showed full knock-out phenotypes of the pigmentation gene tyrosinase and/or embryonic lethal gene pax6 in the founder generation. In addition, our method permitted a large 1 kb deletion. Thus, we describe nearly complete gene knock-out phenotypes in Xenopus laevis F0 embryos. The presented method will help to accelerate the production of knock-out frogs since we can bypass an extra generation of about 1 year in Xenopus laevis. Meantime, our method provides a unique opportunity to rapidly test the developmental effects of disrupting those genes that do not permit growth to an adult able to reproduce. In addition, the protocol shown here is considerably less invasive than the previously used host transfer since our protocol does not require surgery. The experimental scheme presented is potentially applicable to other organisms such as mammals and fish to resolve common issues of mosaicism in founders.

Sadolini värvid / Piret Veigel

Index Scriptorium Estoniae

Veigel, Piret, 1961-

2004-01-01

11. III korraldas Akzo Nobel Taagepera lossis arhitektide õppepäeva. Esinesid Leonhard Lapin ja Rootsi esteetikakeskuse juht Per Nimer, kes tutvustas esteetikakeskuse värvusspetsialistide poolt 2003. a. väljatöötatud trendikaid värvikombinatsioone

A.T. STILL (1828–1917, THE FOUNDER OF OSTEOPATHY: THE COURSE OF LIFE

Directory of Open Access Journals (Sweden)

V. I. Karpova

2016-01-01

Full Text Available Osteopathy is a young medical specialty that has found official acceptance in Russia since 2013. The paper deals with the history of osteo pathy and its founder Andrew Taylor Still (1828–1917. He left a few printed scientific works, including his biography reporting much of his life and activities and the creation of osteopathy. The emergence date of osteopathy is considered to be 22 June 1874. Historically, modern osteopathy has come into existence not so long. We are almost contemporaries of it and its author, but despite this, the international osteopathy community is romanticizing and mythologizing the personality of A.T. Still. In our opinion, the reason is his magnetic personality and brilliant life. Thanks to A.T. Still’s personality, osteopathy may not have been lost among many medical areas and discoveries and continues to develop and attract new supporters. On the other hand, osteopathy is, in the opinion of its founder, a science; therefore a historical rather than mythological approach to A.T. Still’s bibliography, which takes into account all factors for personality formation, is considered correct. Modern science tells that these factors are inheritance, environment, and education. The authors have applied just this scientific approach and, without demolishing the myths, set forth an aim to study the factors forming the world outlook of A.T. Still in order to predict a further way to develope osteopathy in our country.

A qualidade das publicações científicas: considerações de um Editor de Área ao final do mandato Quality of scientific puplications: considerations of an editor at the end of the mandate

Directory of Open Access Journals (Sweden)

Ulysses Paulino de Albuquerque

2009-03-01

Full Text Available A qualidade das publicações científicas vem sendo discutida na atualidade considerando diferentes perspectivas. Neste texto, examina-se alguns dos principais problemas relativos à produção textual em ciência, com ênfase para os considerados de má conduta. Adicionalmente, são apresentadas sugestões para autores, revisores e editores no sentido de evitar condutas inadequadas no processo de publicação de trabalhos científicos.Quality of scientific publications is being currently discussed considering different perspectives. In this text, we examine some of the main problems concerning textual production in science, emphasizing those considered of bad behaviors. Additionally, we present suggestions for authors, reviewers and editors in order to avoid misconducts in the publication process of scientific papers.

The Lublin Philosophical School: Founders, Motives, Characteristics

Directory of Open Access Journals (Sweden)

Mieczysław A. Krąpiec

2015-12-01

Full Text Available The article is focused on the Lublin Philosophical School; it explains its name, presents its founders, reveals the causes of its rise, and introduce the specific character of the School’s philosophy.It starts with stating the fact that in the proper sense, the term “Lublin Philosophical School” describes a way of cultivating realistic (classical philosophy developed in the 1950s by a group of philosophers at the Catholic University of Lublin, Poland. The Lublin Philosophical School is characterized by cognitive realism (the object of cognition is really existing being, maximalism (taking up all existentially important questions, methodological autonomy (in relation to the natural-mathematical sciences and theology, transcendentalism in its assertions (its assertions refer to all reality, methodological-epistemological unity (the same method applied in objectively cultivated philosophical disciplines, coherence (which guarantees the objective unity of the object, and objectivity (achieved by the verifiability of assertions on their own terms, which is achieved by relating them in each instance to objective evidence. The term is the name of the Polish school of realistic (classical philosophy that arose as a response to the Marxism that was imposed administratively on Polish institutions of learning, and also as a response to other philosophical currents dominant at the time such as phenomenology, existentialism, and logical positivism.

TGfU--Would You Know It if You Saw It? Benchmarks from the Tacit Knowledge of the Founders

Science.gov (United States)

Butler, Joy

2014-01-01

This paper explores the tacit expert knowledge and understanding about games curriculum and pedagogy of three men, Len Almond, David Bunker, and Rod Thorpe, credited as the founders of the Teaching Games for Understanding (TGfU) model. The model emerged from teacher practice in the late 1970s and was little theorized at the time, apart from a…

Gerald J. Marks, M.D., FACS (1925-), founder of the Society of American Gastrointestinal Endoscopic Surgeons (SAGES).

Science.gov (United States)

Yeo, Theresa P; Cowan, Scott W; Yeo, Charles J

2018-03-01

This historical vignette describes the professional career of Gerald J. Marks, the founder of the Society of American Gastrointestinal and Endoscopic Surgeons and the International Federation of Societies of Endoscopic Surgeons. Dr. Marks is also the founding Associate Editor of Surgical Endoscopy, which celebrated its 30th anniversary in 2017. Dr. Marks is a renowned colorectal surgeon, an accomplished watercolor artist, and a fascinating personality.

Brief communication: human cranial variation fits iterative founder effect model with African origin.

Science.gov (United States)

von Cramon-Taubadel, Noreen; Lycett, Stephen J

2008-05-01

Recent studies comparing craniometric and neutral genetic affinity matrices have concluded that, on average, human cranial variation fits a model of neutral expectation. While human craniometric and genetic data fit a model of isolation by geographic distance, it is not yet clear whether this is due to geographically mediated gene flow or human dispersal events. Recently, human genetic data have been shown to fit an iterative founder effect model of dispersal with an African origin, in line with the out-of-Africa replacement model for modern human origins, and Manica et al. (Nature 448 (2007) 346-349) have demonstrated that human craniometric data also fit this model. However, in contrast with the neutral model of cranial evolution suggested by previous studies, Manica et al. (2007) made the a priori assumption that cranial form has been subject to climatically driven natural selection and therefore correct for climate prior to conducting their analyses. Here we employ a modified theoretical and methodological approach to test whether human cranial variability fits the iterative founder effect model. In contrast with Manica et al. (2007) we employ size-adjusted craniometric variables, since climatic factors such as temperature have been shown to correlate with aspects of cranial size. Despite these differences, we obtain similar results to those of Manica et al. (2007), with up to 26% of global within-population craniometric variation being explained by geographic distance from sub-Saharan Africa. Comparative analyses using non-African origins do not yield significant results. The implications of these results are discussed in the light of the modern human origins debate. (c) 2007 Wiley-Liss, Inc.

Publicação Eletrônica: a linguagem do e-book na hipermídia

Directory of Open Access Journals (Sweden)

Daniela Carvalho Monteiro Ferreira

2013-12-01

Full Text Available O e-Book é um ambiente virtual e os formatos ePub e Daisy são um conjunto de arquivos interconectados, com potencial de utilização de fontes externas de informação, o que os tornam uma hipermídia. O objetivo deste artigo é apresentar os primeiros resultados sobre a utilização do quadro metodológico de planejamento do conteúdo audiovisual na edição de e-Book. Verificou-se que, assim como na web, os formatos ePub e Daisy, e em especial o primeiro, possui o potencial de utilização de recursos audiovisuais que podem fazer do resultado extrapolar a linguagem tradicional do livro impresso, tornando-os multimídia. Surge então o questionamento sobre o papel do editor de e-Book enquanto publicação eletrônica baseado no hipertexto, que assemelha-se com o de um roteirista para hipermídia.

A genetic cluster of patients with variant xeroderma pigmentosum with two different founder mutations.

Science.gov (United States)

Munford, V; Castro, L P; Souto, R; Lerner, L K; Vilar, J B; Quayle, C; Asif, H; Schuch, A P; de Souza, T A; Ienne, S; Alves, F I A; Moura, L M S; Galante, P A F; Camargo, A A; Liboredo, R; Pena, S D J; Sarasin, A; Chaibub, S C; Menck, C F M

2017-05-01

Xeroderma pigmentosum (XP) is a rare human syndrome associated with hypersensitivity to sunlight and a high frequency of skin tumours at an early age. We identified a community in the state of Goias (central Brazil), a sunny and tropical region, with a high incidence of XP (17 patients among approximately 1000 inhabitants). To identify gene mutations in the affected community and map the distribution of the affected alleles, correlating the mutations with clinical phenotypes. Functional analyses of DNA repair capacity and cell-cycle responses after ultraviolet exposure were investigated in cells from local patients with XP, allowing the identification of the mutated gene, which was then sequenced to locate the mutations. A specific assay was designed for mapping the distribution of these mutations in the community. Skin primary fibroblasts showed normal DNA damage removal but abnormal DNA synthesis after ultraviolet irradiation and deficient expression of the Polη protein, which is encoded by POLH. We detected two different POLH mutations: one at the splice donor site of intron 6 (c.764 +1 G>A), and the other in exon 8 (c.907 C>T, p.Arg303X). The mutation at intron 6 is novel, whereas the mutation at exon 8 has been previously described in Europe. Thus, these mutations were likely brought to the community long ago, suggesting two founder effects for this rare disease. This work describes a genetic cluster involving POLH, and, particularly unexpected, with two independent founder mutations, including one that likely originated in Europe. © 2016 British Association of Dermatologists.

Eduard Strasburger (1844-1912): founder of modern plant cell biology.

Science.gov (United States)

Volkmann, Dieter; Baluška, František; Menzel, Diedrik

2012-10-01

Eduard Strasburger, director of the Botany Institute and the Botanical Garden at the University of Bonn from 1881 to 1912, was one of the most admirable scientists in the field of plant biology, not just as the founder of modern plant cell biology but in addition as an excellent teacher who strongly believed in "education through science." He contributed to plant cell biology by discovering the discrete stages of karyokinesis and cytokinesis in algae and higher plants, describing cytoplasmic streaming in different systems, and reporting on the growth of the pollen tube into the embryo sac and guidance of the tube by synergides. Strasburger raised many problems which are hot spots in recent plant cell biology, e.g., structure and function of the plasmodesmata in relation to phloem loading (Strasburger cells) and signaling, mechanisms of cell plate formation, vesicle trafficking as a basis for most important developmental processes, and signaling related to fertilization.

KT seminar on entrepreneurship | "From CERN engineer to company founder: my journey" by Julio Lucas | 26 September

CERN Multimedia

2016-01-01

Europe needs its economy to be boosted by the ideas of its most talented scientists and engineers. One of the best ways in which these ideas may contribute to society is by creating a new business. In this Knowledge Transfer seminar, Julio Lucas, Technical Director and co-founder of Elytt Energy and former CERN engineer gives a personal view on how to make your first steps in entrepreneurship.    

Caracterização das publicações periódicas em fonoaudiologia e neurociências: estudo sobre os tipos e temas de artigos e visibilidade na área de linguagem Periodicals' profile in speech-language and hearing pathology and neurosciences: study on types and headers of the language area articles, and their visibility

Directory of Open Access Journals (Sweden)

Sandrelli Virginio de Vasconcelos

2009-03-01

Full Text Available TEMA: caracterização das publicações periódicas em Fonoaudiologia e Neurociências: estudo sobre os tipos e temas de artigos e visibilidade na área de linguagem. OBJETIVO: caracterizar as publicações periódicas em Fonoaudiologia estudando os artigos da área de Linguagem relacionados às Neurociências no período de 2002 a 2006. CONCLUSÃO: ficou evidente um aumento crescente de publicações em Linguagem e em Neurociências nos últimos cinco anos. Contudo, o número de publicações em determinados temas como a Dislexia, a Doença de Alzheimer e o Transtorno do Déficit de Atenção / Hiperatividade ainda mostra-se resumido.BACKGROUND: periodicals' profile in speechlanguage and hearing pathology and neurosciences: study on types and headers of the language articles, and their visibility. PURPOSE: to characterize periodicals in SpeechLanguage Pathology and Hearing, studying the articles of the Language's area related to Neurosciences in the period from 2002 to 2006. CONCLUSION: increasing publication in Language and Neurosciences in the last five years has been evident. However, number of publications in certain headers, such as dyslexia, Alzheimer's disease and AttentionDeficit/Hyperactivity Disorder are still abridged.

Kolm ministrit valgustasid Kagu-Eesti omavalitsusjuhte / Mari-Anne Leht

Index Scriptorium Estoniae

Leht, Mari-Anne, 1950-

2003-01-01

Valgamaal Taageperas räägiti Kagu-Eesti omavalitsusjuhtidele haridusest, haridusreformist ja rahast. Kohal olid ka haridus- ja teadusminister Toivo Maimets, siseminister Jaan Õunapuu ja majandusminister Meelis Atonen. Kommenteerivad Rein Randver, Pille Tali, Sirje Tobreluts jt. Vt. samas: Hannes Võrno kaebas rasket elu

Praostkondade uudised : Viljandi. Põltsamaa

Index Scriptorium Estoniae

2006-01-01

10.-11. aug. Helme kogudust külastanud norra koori Lillebergkvartetten kontserdist Taageperas Helme valla hooldekodus. 15. aug. Helme Maarja koguduses peetud maarjapäeval saatis koguduse laule Tõrva puhkpilliorkester. Põltsamaa kogudus külastas 14.-18. aug. sõpruskogudusi Soomes, andes barokkmuusika kontserdi

Fanconi anemia founder mutation in Macedonian patients.

Science.gov (United States)

Madjunkova, Svetlana; Kocheva, Svetlana A; Plaseska-Karanfilska, Dijana

2014-01-01

Fanconi anemia (FA) is a rare autosomal recessive disorder clinically characterized by developmental abnormalities, progressive bone marrow failure (BMF) and profound cancer predisposition. Approximately 65% of all affected individuals have mutation in the FANCA (Fanconi anemia complementation group A) gene. The mutation spectrum of the FANCA gene is highly heterogeneous. FA-A is usually associated with private FANCA mutations in individual families. We describe 3 unrelated patients with FA with a similar clinical presentation: BMF, renal anomalies and café-au-lait pigmentation without major skeletal abnormality. The molecular analysis of the FANCA gene using the FA MLPA kit P031-A2/P032 FANCA, showed homozygous deletion of exon 3 in all 3 patients. Molecular analysis of the flanking regions of exon 3 precisely defined unique deletion of 2,040 bp and duplication of C (1788_3828dupC). These are the first 3 patients homozygous for deletion of FANCA exon 3 described to date. Although not related, the patients originated from the same Gypsy-like ethnic population. We conclude that c.190-256_283 + 1680del2040 dupC mutation in the FANCA gene is a founder mutation in Macedonian FA patients of Gypsy-like ethnic origin. Our finding has very strong implications for these patients in formulating diagnostic and carrier-screening strategy for BMF and FA and to enable comprehensive genetic counseling. © 2013 S. Karger AG, Basel.

The founder of the church of Saint George at Pološko

Directory of Open Access Journals (Sweden)

Pavlović Dragana

2015-01-01

Full Text Available The paper seeks to establish who was the founder of the church of Saint George at Pološko and revise the conclusions of previous researchers regarding this issue. According to the opinion commonly adopted in the scholarly literature, Jovan Dragušin, a cousin of King Dušan, had merely undertaken the construction of church at Pološko, whereas his mother was responsible for the completion of construction and painting of frescoes in the church. Through an analysis of written and visual sources the conclusion is reached that the sole person responsible for the construction and painting of the church at Pološko was the nun Maria, the mother of Jovan Dragušin. [Projekat Ministarstva nauke Republike Srbije, br. 177036: Srpska srednjovekovna umetnost i njen evropski kontekst

A Middle Eastern Founder Mutation Expands the Genotypic and Phenotypic Spectrum of Mitochondrial MICU1 Deficiency: A Report of 13 Patients.

Science.gov (United States)

Musa, Sara; Eyaid, Wafaa; Kamer, Kimberli; Ali, Rehab; Al-Mureikhi, Mariam; Shahbeck, Noora; Al Mesaifri, Fatma; Makhseed, Nawal; Mohamed, Zakkiriah; AlShehhi, Wafaa Ali; Mootha, Vamsi K; Juusola, Jane; Ben-Omran, Tawfeg

2018-05-03

MICU1 encodes a Ca 2+ sensing, regulatory subunit of the mitochondrial uniporter, a selective calcium channel within the organelle's inner membrane. Ca 2+ entry into mitochondria helps to buffer cytosolic Ca 2+ transients and also activates ATP production within the organelle. Mutations in MICU1 have previously been reported in 17 children from nine families with muscle weakness, fatigue, normal lactate, and persistently elevated creatine kinase, as well as variable features that include progressive extrapyramidal signs, learning disabilities, nystagmus, and cataracts. In this study, we report the clinical features of an additional 13 patients from consanguineous Middle Eastern families with recessive mutations in MICU1. Of these patients, 12/13 are homozygous for a novel founder mutation c.553C>T (p.Q185*) that is predicted to lead to a complete loss of function of MICU1, while one patient is compound heterozygous for this mutation and an intragenic duplication of exons 9 and 10. The founder mutation occurs with a minor allele frequency of 1:60,000 in the ExAC database, but in ~1:500 individual in the Middle East. All 13 of these patients presented with developmental delay, learning disability, muscle weakness and easy fatigability, and failure to thrive, as well as additional variable features we tabulate. Consistent with previous cases, all of these patients had persistently elevated serum creatine kinase with normal lactate levels, but they also exhibited elevated transaminase enzymes. Our work helps to better define the clinical sequelae of MICU1 deficiency. Furthermore, our work suggests that targeted analysis of the MICU1 founder mutation in Middle Eastern patients may be warranted.

Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.

Directory of Open Access Journals (Sweden)

Jennifer K Lowe

2009-02-01

Full Text Available It has been argued that the limited genetic diversity and reduced allelic heterogeneity observed in isolated founder populations facilitates discovery of loci contributing to both Mendelian and complex disease. A strong founder effect, severe isolation, and substantial inbreeding have dramatically reduced genetic diversity in natives from the island of Kosrae, Federated States of Micronesia, who exhibit a high prevalence of obesity and other metabolic disorders. We hypothesized that genetic drift and possibly natural selection on Kosrae might have increased the frequency of previously rare genetic variants with relatively large effects, making these alleles readily detectable in genome-wide association analysis. However, mapping in large, inbred cohorts introduces analytic challenges, as extensive relatedness between subjects violates the assumptions of independence upon which traditional association test statistics are based. We performed genome-wide association analysis for 15 quantitative traits in 2,906 members of the Kosrae population, using novel approaches to manage the extreme relatedness in the sample. As positive controls, we observe association to known loci for plasma cholesterol, triglycerides, and C-reactive protein and to a compelling candidate loci for thyroid stimulating hormone and fasting plasma glucose. We show that our study is well powered to detect common alleles explaining >/=5% phenotypic variance. However, no such large effects were observed with genome-wide significance, arguing that even in such a severely inbred population, common alleles typically have modest effects. Finally, we show that a majority of common variants discovered in Caucasians have indistinguishable effect sizes on Kosrae, despite the major differences in population genetics and environment.

Estado da Arte da Publicação Nacional e Internacional sobre Neuromarketing e Neuroeconomia

Directory of Open Access Journals (Sweden)

Caissa Veloso e Sousa

2016-03-01

Full Text Available Nas últimas três décadas os estudos envolvendo as áreas de Neurociência e Engenharia biomédica e que convergem para a possibilidade de mapeamento e avaliação do cérebro in vivo apresentaram desenvolvimento significativo, possibilitando a emersão, nas ciências sociais, dos campos de pesquisa chamados de Neuromarketing e Neuroeconomia. No presente trabalho foram analisadas as publicações existentes sobre o tema em bases nacionais e internacionais. Pesquisaram-se as seguintes bases de dados: Associação Nacional de Pós-Graduação e Pesquisa em Administração (ANPAD; Ebscohost Research Databases (EBSCO, Google Acadêmico, Portal de Periódicos Capes, PubMed (US National Library of Medicine National Institutes of Health; Scientific Eletronic Library Online (SCIELO, Scientific Periodicals Eletronic Library (SPELL. A predominância de trabalhos teóricos reflete uma possível dificuldade de se realizar pesquisas empíricas, o que pode estar relacionado tanto ao custo financeiro efetivo dessas pesquisas, quanto ao acesso aos canais integrativos de pesquisa, que dependem de uma equipe transdisciplinar.

Ludwig Edinger (1855-1918): founder of modern neuroanatomy.

Science.gov (United States)

Prithishkumar, Ivan James

2012-03-01

Ludwig Edinger, a German neurologist is considered as one of the founders of modern neuroanatomy. He was conferred the degree of Doctor of Medicine at the University of Strassburg. His observation of small living organisms under a microscope at an early age led him to study medicine. Edinger had many discoveries to his credit. He was the first to describe the ventral and dorsal spinocerebellar tracts, to distinguish between paleo-encephalon and neo-encephalon, and between paleo-cerebellum and neo-cerebellum. He coined the terms "gnosis" and "praxis," which were later adopted in psychological descriptions of agnosia and apraxia. He identified the Edinger-Westphal nucleus in 1885 and was the first to describe the syndrome of thalamic pain. Edinger worked with renowned clinicians and published a large number of papers. He founded the Neurological Institute at the Goethe University in Frankfurt, which is the oldest neurological Institute in Germany. Edinger was a rare combination of a profound scientist, a brilliant teacher, a fine artist, and a noted hypnotist. While at the height of his career, he underwent a surgery and died a few hours later. It was his last will that his brain should be dissected in his own institute. It showed extraordinarily well-developed occipital lobes as well as other unusual features. Copyright © 2011 Wiley-Liss, Inc.

Mõisa peale kulub miljoneid kroone / Peeter Raidla

Index Scriptorium Estoniae

Raidla, Peeter, 1955-

2005-01-01

Ärimehed renoveerivad Eestimaa mõisaid. Lähemalt Taagepera lossist, Atla mõisast, Liigvalla mõisast, Esna mõisast, Ingliste mõisast, Nabala mõisast, Ontika mõisast, Kolu mõisast, Hõreda mõisast, Vihterpalu mõisast, Kalvi mõisast, Rägavere mõisast. Loetletud mõisate praegused omanikud

XPC gene mutations in families with xeroderma pigmentosum from Pakistan; prevalent founder effect.

Science.gov (United States)

Ijaz, Ambreen; Basit, Sulman; Gul, Ajab; Batool, Lilas; Hussain, Abrar; Afzal, Sibtain; Ramzan, Khushnooda; Ahmad, Jamil; Wali, Abdul

2018-03-23

Xeroderma pigmentosum (XP) is a rare autosomal recessive skin disorder characterized by hyperpigmentation, premature skin aging, ocular and cutaneous photosensitivity, and increased risk of skin carcinoma. We investigated seven consanguineous XP families with nine patients from Pakistan. All the Patients exhibited typical clinical symptoms of XP since first year of life. Whole genome SNP genotyping identified a 14 Mb autozygous region segregating with the disease phenotype on chromosome 3p25.1. DNA sequencing of XPC gene revealed a founder homozygous splice site mutation (c.2251-1G>C) in patients from six families (A-F) and a homozygous nonsense mutation (c.1399C>T; p.Gln467*) in patients of family G. This is the first report of XPC mutations, underlying XP phenotype, in Pakistani population. © 2018 Japanese Teratology Society.

Mitochondrial Genome Diversity of Native Americans Supports a Single Early Entry of Founder Populations into America

Science.gov (United States)

Silva Jr., Wilson A.; Bonatto, Sandro L.; Holanda, Adriano J.; Ribeiro-dos-Santos, Andrea K.; Paixão, Beatriz M.; Goldman, Gustavo H.; Abe-Sandes, Kiyoko; Rodriguez-Delfin, Luis; Barbosa, Marcela; Paçó-Larson, Maria Luiza; Petzl-Erler, Maria Luiza; Valente, Valeria; Santos, Sidney E. B.; Zago, Marco A.

2002-01-01

There is general agreement that the Native American founder populations migrated from Asia into America through Beringia sometime during the Pleistocene, but the hypotheses concerning the ages and the number of these migrations and the size of the ancestral populations are surrounded by controversy. DNA sequence variations of several regions of the genome of Native Americans, especially in the mitochondrial DNA (mtDNA) control region, have been studied as a tool to help answer these questions. However, the small number of nucleotides studied and the nonclocklike rate of mtDNA control-region evolution impose several limitations to these results. Here we provide the sequence analysis of a continuous region of 8.8 kb of the mtDNA outside the D-loop for 40 individuals, 30 of whom are Native Americans whose mtDNA belongs to the four founder haplogroups. Haplogroups A, B, and C form monophyletic clades, but the five haplogroup D sequences have unstable positions and usually do not group together. The high degree of similarity in the nucleotide diversity and time of differentiation (i.e., ∼21,000 years before present) of these four haplogroups support a common origin for these sequences and suggest that the populations who harbor them may also have a common history. Additional evidence supports the idea that this age of differentiation coincides with the process of colonization of the New World and supports the hypothesis of a single and early entry of the ancestral Asian population into the Americas. PMID:12022039

A Founder Large Deletion Mutation in Xeroderma Pigmentosum-Variant Form in Tunisia: Implication for Molecular Diagnosis and Therapy

Directory of Open Access Journals (Sweden)

Mariem Ben Rekaya

2014-01-01

Full Text Available Xeroderma pigmentosum Variant (XP-V form is characterized by a late onset of skin symptoms. Our aim is the clinical and genetic investigations of XP-V Tunisian patients in order to develop a simple tool for early diagnosis. We investigated 16 suspected XP patients belonging to ten consanguineous families. Analysis of the POLH gene was performed by linkage analysis, long range PCR, and sequencing. Genetic analysis showed linkage to the POLH gene with a founder haplotype in all affected patients. Long range PCR of exon 9 to exon 11 showed a 3926 bp deletion compared to control individuals. Sequence analysis demonstrates that this deletion has occurred between two Alu-Sq2 repetitive sequences in the same orientation, respectively, in introns 9 and 10. We suggest that this mutation POLH NG_009252.1: g.36847_40771del3925 is caused by an equal crossover event that occurred between two homologous chromosomes at meiosis. These results allowed us to develop a simple test based on a simple PCR in order to screen suspected XP-V patients. In Tunisia, the prevalence of XP-V group seems to be underestimated and clinical diagnosis is usually later. Cascade screening of this founder mutation by PCR in regions with high frequency of XP provides a rapid and cost-effective tool for early diagnosis of XP-V in Tunisia and North Africa.

Novel Founder Mutation in FANCA Gene (c.3446_3449dupCCCT) Among Romani Patients from the Balkan Region.

Science.gov (United States)

Dimishkovska, Marija; Kotori, Vjosa Mulliqi; Gucev, Zoran; Kocheva, Svetlana; Polenakovic, Momir; Plaseska-Karanfilska, Dijana

2018-01-20

Fanconi anemia is a rare autosomal recessive or X-linked disorder characterised by clinical and genetic heterogeneity. Most fanconi anemia patients harbour homozygous or double heterozygous mutations in the FANCA (60-65%), FANCC (10-15%), FANCG (~10%) or FANCD2 (3-6%) genes. We have already reported the FANCA variant c.190-256_283+1680del2040dupC as a founder mutation among Macedonian fanconi anemia patients of Gypsy-like ethnic origin. Here, we present a novel FANCA mutation in two patients from Macedonia and Kosovo. The novel FANCA mutation c.3446_3449dupCCCT was identified in two fanconi anemia patients with Romany ethnicity; a 2-year-old girl from Macedonia who is a compound heterozygote for a previously reported FANCA c.190-256_283+1680del2040dupC and the novel mutation and a 10-year-old girl from Kosovo who is a homozygote for the novel FANCA c.3446_3449dupCCCT mutation. The novel mutation is located in exon 35 in the FAAP20-binding domain which plays a crucial role in the FANCA -FAAP20 interaction and is required for integrity of the fanconi anemia pathway. The finding of the FANCA c.3446_3449dupCCCT mutation in two unrelated FA patients with Romani ethnicity from Macedonia and Kosovo suggests it is a founder mutation in the Romani population living in the Balkan region.

A founder large deletion mutation in Xeroderma pigmentosum-Variant form in Tunisia: implication for molecular diagnosis and therapy.

Science.gov (United States)

Ben Rekaya, Mariem; Laroussi, Nadia; Messaoud, Olfa; Jones, Mariem; Jerbi, Manel; Naouali, Chokri; Bouyacoub, Yosra; Chargui, Mariem; Kefi, Rym; Fazaa, Becima; Boubaker, Mohamed Samir; Boussen, Hamouda; Mokni, Mourad; Abdelhak, Sonia; Zghal, Mohamed; Khaled, Aida; Yacoub-Youssef, Houda

2014-01-01

Xeroderma pigmentosum Variant (XP-V) form is characterized by a late onset of skin symptoms. Our aim is the clinical and genetic investigations of XP-V Tunisian patients in order to develop a simple tool for early diagnosis. We investigated 16 suspected XP patients belonging to ten consanguineous families. Analysis of the POLH gene was performed by linkage analysis, long range PCR, and sequencing. Genetic analysis showed linkage to the POLH gene with a founder haplotype in all affected patients. Long range PCR of exon 9 to exon 11 showed a 3926 bp deletion compared to control individuals. Sequence analysis demonstrates that this deletion has occurred between two Alu-Sq2 repetitive sequences in the same orientation, respectively, in introns 9 and 10. We suggest that this mutation POLH NG_009252.1: g.36847_40771del3925 is caused by an equal crossover event that occurred between two homologous chromosomes at meiosis. These results allowed us to develop a simple test based on a simple PCR in order to screen suspected XP-V patients. In Tunisia, the prevalence of XP-V group seems to be underestimated and clinical diagnosis is usually later. Cascade screening of this founder mutation by PCR in regions with high frequency of XP provides a rapid and cost-effective tool for early diagnosis of XP-V in Tunisia and North Africa.

Investigações sobre o ensino de Genética e Biologia Molecular no Ensino Médio brasileiro: reflexões sobre as publicações científicas Research on the teaching of Genetics and Molecular Biology in Brazilian High School: reflections about scientific publications

Directory of Open Access Journals (Sweden)

José Romário de Melo

2009-01-01

Full Text Available Com o objetivo de analisar as publicações relacionadas ao ensino de Genética e Biologia Molecular no Ensino Médio brasileiro, foram consideradas reflexões sobre várias publicações científicas mediante revisão bibliográfica. Foram analisados trabalhos publicados entre 1999 a 2008. A Revista Genética na Escola se destacou quanto à quantidade de artigos publicados. As publicações puderam ser classificadas em diversas categorias, como: análise de livro didático (ALD, histórico (HIS, intrainterdisciplinaridade (IID, metodologia de ensino (MEE, propostas curriculares (PRC e outros (OUT. Embora compatíveis em quantidade, artigos das categorias ALD, HIS e PRC encontram-se publicados em pouquíssima quantidade. O número de artigos publicados nas categorias IID e MEE soma quase 73% das publicações encontradas, em relação às demais (as outras categorias juntas somam aproximadamente 27%. Este estudo possibilitou considerar que ainda é incipiente a pesquisa voltada ao ensino de Genética e Biologia Molecular, com relação ao Ensino Médio na escola básica brasileira.The objective of this work was to analyze the publications related to the teaching of Genetics and Molecular Biology in Brazilian High Schools. We analyzed studies published from 1999 to 2008. The Revista Genética na Escola presents the most published articles. The publications were classified into different categories, such as: textbook analysis (ALD, history (HIS, intra-interdisciplinarity (IID, teaching methodology (MEE, curriculum proposals (PRC and other (OUT. Equivalent numbers of articles in ALD, HIS and PRC categories are published in very low quantity, however the number of articles published in categories IID and MEE total almost 73% of the publications found in the others (all other categories together total about 27%. This study has considered that research dedicated to the teaching of Genetics and Molecular Biology is still in its early stages, related to

Hematological consequences of a FANCG founder mutation in Black South African patients with Fanconi anemia.

Science.gov (United States)

Feben, Candice; Kromberg, Jennifer; Wainwright, Rosalind; Stones, David; Poole, Janet; Haw, Tabitha; Krause, Amanda

2015-03-01

Fanconi anemia (FA) is a rare disorder of DNA repair, associated with various somatic abnormalities but characterized by hematological disease that manifests as bone marrow aplasia and malignancy. The mainstay of treatment, in developed nations, is hematopoietic stem cell transplantation (HSCT) with subsequent surveillance for solid organ and non-hematological malignancies. In South Africa, FA in the Black population is caused by a homozygous deletion mutation in the FANCG gene in more than 80% of cases. Many affected patients are not diagnosed until late in the disease course when severe cytopenia and bone marrow aplasia are already present. Most patients are not eligible for HSCT at this late stage of the disease, even when it is available in the state health care system. In this study, the hematological presentation and disease progression in 30 Black South African patients with FA, confirmed to have the FANCG founder mutation, were evaluated and compared to those described in other FA cohorts. Our results showed that patients, homozygous for the FANCG founder mutation, present with severe cytopenia but progress to bone marrow failure at similar ages to other individuals affected with FA of heterogeneous genotype. Further, the incidence of myelodysplastic syndrome is similar to that which has been previously described in other FA cohorts. Although severe cytopenia at presentation may be predicted by a higher number of somatic anomalies, the recognition of the physical FA phenotype in Black South African patients is challenging and may not be useful in expediting referral of suspected FA patients for tertiary level investigations and care. Given the late but severe hematological presentation of FA in Black South African patients, an investigative strategy is needed for earlier recognition of affected individuals to allow for possible HSCT and management of bone marrow disease. Copyright © 2014 Elsevier Inc. All rights reserved.

Novel Founder Mutation in FANCA Gene (c.3446_3449dupCCCT) Among Romani Patients from the Balkan Region

OpenAIRE

Marija Dimishkovska; Vjosa Mulliqi Kotori; Zoran Gucev; Svetlana Kocheva; Momir Polenakovic; Dijana Plaseska-Karanfilska

2018-01-01

Background: Fanconi anemia is a rare autosomal recessive or X-linked disorder characterised by clinical and genetic heterogeneity. Most fanconi anemia patients harbour homozygous or double heterozygous mutations in the FANCA (60-65%), FANCC (10-15%), FANCG (~10%) or FANCD2 (3-6%) genes. We have already reported the FANCA variant c.190–256_283+1680del2040dupC as a founder mutation among Macedonian fanconi anemia patients of Gypsy-like ethnic origin. Here, we present a novel FANCA mutation in t...

Distribution and medical impact of loss-of-function variants in the Finnish founder population.

Directory of Open Access Journals (Sweden)

Elaine T Lim

2014-07-01

Full Text Available Exome sequencing studies in complex diseases are challenged by the allelic heterogeneity, large number and modest effect sizes of associated variants on disease risk and the presence of large numbers of neutral variants, even in phenotypically relevant genes. Isolated populations with recent bottlenecks offer advantages for studying rare variants in complex diseases as they have deleterious variants that are present at higher frequencies as well as a substantial reduction in rare neutral variation. To explore the potential of the Finnish founder population for studying low-frequency (0.5-5% variants in complex diseases, we compared exome sequence data on 3,000 Finns to the same number of non-Finnish Europeans and discovered that, despite having fewer variable sites overall, the average Finn has more low-frequency loss-of-function variants and complete gene knockouts. We then used several well-characterized Finnish population cohorts to study the phenotypic effects of 83 enriched loss-of-function variants across 60 phenotypes in 36,262 Finns. Using a deep set of quantitative traits collected on these cohorts, we show 5 associations (p<5×10⁻⁸ including splice variants in LPA that lowered plasma lipoprotein(a levels (P = 1.5×10⁻¹¹⁷. Through accessing the national medical records of these participants, we evaluate the LPA finding via Mendelian randomization and confirm that these splice variants confer protection from cardiovascular disease (OR = 0.84, P = 3×10⁻⁴, demonstrating for the first time the correlation between very low levels of LPA in humans with potential therapeutic implications for cardiovascular diseases. More generally, this study articulates substantial advantages for studying the role of rare variation in complex phenotypes in founder populations like the Finns and by combining a unique population genetic history with data from large population cohorts and centralized research access to National Health

A iniciação científica e a publicação na graduação como meios de qualidade na formação de ensino superior: uma entrevista com José Roberto Rus Perez

Directory of Open Access Journals (Sweden)

Lucio José Dutra Lord

2014-11-01

Full Text Available O tema da qualidade da formação profissional há muito tem dirigido as políticas educacionais e influenciado nas matrizes curriculares dos cursos de graduação no país. Contudo, a questão extrapola este espaço e envolve, cada vez mais, as experiências extraclasses. Deste modo a extensão, pesquisa e publicação universitárias assumem papel relevante para a melhoria do ensino. Nesta entrevista o Professor e Pesquisador Livre Docente José Roberto Rus Perez nos fala da importância da pesquisa e publicação na formação de ensino superior. Seu relato de 30 anos de experiência no Núcleo de Estudos em Políticas Públicas (NEEP/UNICAMP evidencia alguns pontos fundamentais para que o ensino de graduação experiencie a pesquisa e divulgação, através da publicação, como pilares de sustentação do bom ensino. Ele também demonstra a estreita relação entre a formação na graduação e as dificuldades vividas na pós-graduação no país, sobretudo pela carência da pesquisa que é, sempre, tão necessária ao trabalho do profissional no mercado ou no setor público, na licenciatura ou no bacharelado. Cabe ressaltar também que o professor José Roberto Rus Perez é membro do Conselho Consultivo Nacional da Revista Eventos Pedagógicos – REP’s.

Novel Founder Mutation in FANCA Gene (c.3446_3449dupCCCT Among Romani Patients from the Balkan Region

Directory of Open Access Journals (Sweden)

Marija Dimishkovska

2018-02-01

Full Text Available Background: Fanconi anemia is a rare autosomal recessive or X-linked disorder characterised by clinical and genetic heterogeneity. Most fanconi anemia patients harbour homozygous or double heterozygous mutations in the FANCA (60-65%, FANCC (10-15%, FANCG (~10% or FANCD2 (3-6% genes. We have already reported the FANCA variant c.190–256_283+1680del2040dupC as a founder mutation among Macedonian fanconi anemia patients of Gypsy-like ethnic origin. Here, we present a novel FANCA mutation in two patients from Macedonia and Kosovo. Case Report: The novel FANCA mutation c.3446_3449dupCCCT was identified in two fanconi anemia patients with Romany ethnicity; a 2-year-old girl from Macedonia who is a compound heterozygote for a previously reported FANCA c.190-256_283+1680del2040dupC and the novel mutation and a 10-year-old girl from Kosovo who is a homozygote for the novel FANCA c.3446_3449dupCCCT mutation. The novel mutation is located in exon 35 in the FAAP20-binding domain which plays a crucial role in the FANCA-FAAP20 interaction and is required for integrity of the fanconi anemia pathway. Conclusion: The finding of the FANCA c.3446_3449dupCCCT mutation in two unrelated FA patients with Romani ethnicity from Macedonia and Kosovo suggests it is a founder mutation in the Romani population living in the Balkan region

International distribution and age estimation of the Portuguese BRCA2 c.156_157insAlu founder mutation

DEFF Research Database (Denmark)

Peixoto, Ana; Santos, Catarina; Pinheiro, Manuela

2011-01-01

The c.156_157insAlu BRCA2 mutation has so far only been reported in hereditary breast/ovarian cancer (HBOC) families of Portuguese origin. Since this mutation is not detectable using the commonly used screening methodologies and must be specifically sought, we screened for this rearrangement...... individuals requesting predictive testing living in France and in the USA, all being Portuguese immigrants. After performing an extensive haplotype study in carrier families, we estimate that this founder mutation occurred 558 +/- 215 years ago. We further demonstrate significant quantitative differences...... HBOC families from Portugal or with Portuguese ancestry are specifically tested for this rearrangement....

HealthSouth's most wanted. Founder and former chairman and CEO Richard Scrushy is indicted for 85 counts of conspiracy, fraud and money laundering.

Science.gov (United States)

Piotrowski, Julie

2003-11-10

Wake-up call for the industry or an isolated case of corporate chicanery? Healthcare experts are divided on the import of Richard Scrushy's indictment on 85 counts last week in connection with the financial scandal at HealthSouth Corp. The indictment alleges the company founder relied on electronic and telephone surveillance, threats and intimidation to control his accomplices.

A Pesquisa Design Science no Brasil segundo as Publicações em Administração da Informação

Directory of Open Access Journals (Sweden)

José Osvaldo De Sordi

2015-09-01

Full Text Available Este artigo realiza uma revisão da literatura das pesquisas publicadas pela academia brasileira de administração da informação com o objetivo de analisar o quanto se aplica e como se pratica os princípios da pesquisa design science (DS. A amostra da pesquisa foi extraída de 257 artigos publicados por esta área, nos anais do EnANPAD, no período 2008-2012. Observou-se o interesse manifesto dos pesquisadores pela DS, considerando que há publicações referentes ao desenvolvimento de novos artefatos. Estas pesquisas, porém, não observaram aspectos centrais da DS, como: associação do artefato a problemas do ambiente de negócios e evidenciação da utilidade do artefato por meio de testes com variáveis associadas ao problema.

Preconception carrier screening for multiple disorders: evaluation of a screening offer in a Dutch founder population.

Science.gov (United States)

Mathijssen, Inge B; Holtkamp, Kim C A; Ottenheim, Cecile P E; van Eeten-Nijman, Janneke M C; Lakeman, Phillis; Meijers-Heijboer, Hanne; van Maarle, Merel C; Henneman, Lidewij

2018-02-01

Technological developments have enabled carrier screening for multiple disorders. This study evaluated experiences with a preconception carrier screening offer for four recessive disorders in a Dutch founder population. Questionnaires were completed by 182 attendees pretesting and posttesting and by 137 non-attendees. Semistructured interviews were conducted with seven of the eight carrier couples. Attendees were mainly informed about the existence of screening by friends/colleagues (49%) and family members (44%). Familiarity with the genetic disorders was high. Knowledge after counseling increased (p influencers (family/friends) can be used to raise awareness of a screening offer. Our findings provide lessons for the implementation of expanded carrier screening panels in other communities and other settings.

Founder Fukutin mutation causes Walker-Warburg syndrome in four Ashkenazi Jewish families.

Science.gov (United States)

Chang, Wendy; Winder, Thomas L; LeDuc, Charles A; Simpson, Lynn L; Millar, William S; Dungan, Jeffrey; Ginsberg, Norman; Plaga, Stacey; Moore, Steven A; Chung, Wendy K

2009-06-01

Walker-Warburg syndrome (WWS) is a genetically heterogeneous congenital muscular dystrophy caused by abnormal glycosylation of alpha-dystroglycan (alpha-DG) that is associated with brain malformations and eye anomalies. The Fukutin (FKTN) gene, which causes autosomal recessively inherited WWS is most often associated with Fukuyama congenital muscular dystrophy in Japan. We describe the clinical features of four nonconsanguinous Ashkenazi Jewish families with WWS and identify the underlying genetic basis for WWS. We screened for mutations in POMGnT1, POMT1, POMT2, and FKTN, genes causing WWS, by dideoxy sequence analysis. We identified an identical homozygous c.1167insA mutation in the FKTN gene on a common haplotype in all four families and identified 2/299 (0.7%) carriers for the c.1167insA mutation among normal American Ashkenazi Jewish adults. These data suggest that the c.1167insA FKTN mutation described by us is a founder mutation that can be used to target diagnostic testing and carrier screening in the Ashkenazi Jewish population. Copyright (c) 2009 John Wiley & Sons, Ltd.

Founder Fukutin mutation causes Walker-Warburg syndrome in four Ashkenazi Jewish families†

Science.gov (United States)

Chang, Wendy; Winder, Thomas L.; LeDuc, Charles A.; Simpson, Lynn L.; Millar, William S.; Dungan, Jeffrey; Ginsberg, Norman; Plaga, Stacey; Moore, Steven A.; Chung, Wendy K.

2009-01-01

Objective Walker-Warburg syndrome (WWS) is a genetically heterogeneous congenital muscular dystrophy caused by abnormal glycosylation of α-dystroglycan (α-DG) that is associated with brain malformations and eye anomalies. The Fukutin (FKTN) gene, which causes autosomal recessively inherited WWS is most often associated with Fukuyama congenital muscular dystrophy in Japan. We describe the clinical features of four nonconsanguinous Ashkenazi Jewish families with WWS and identify the underlying genetic basis for WWS. Method We screened for mutations in POMGnT1, POMT1, POMT2, and FKTN, genes causing WWS, by dideoxy sequence analysis. Results We identified an identical homozygous c.1167insA mutation in the FKTN gene on a common haplotype in all four families and identified 2/299 (0.7%) carriers for the c.1167insA mutation among normal American Ashkenazi Jewish adults. Conclusion These data suggest that the c.1167insA FKTN mutation described by us is a founder mutation that can be used to target diagnostic testing and carrier screening in the Ashkenazi Jewish population. PMID:19266496

Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus

Science.gov (United States)

Liao, Hua-Xin; Lynch, Rebecca; Zhou, Tongqing; Gao, Feng; Alam, S. Munir; Boyd, Scott D.; Fire, Andrew Z.; Roskin, Krishna M.; Schramm, Chaim A.; Zhang, Zhenhai; Zhu, Jiang; Shapiro, Lawrence; Mullikin, James C.; Gnanakaran, S.; Hraber, Peter; Wiehe, Kevin; Kelsoe, Garnett; Yang, Guang; Xia, Shi-Mao; Montefiori, David C.; Parks, Robert; Lloyd, Krissey E.; Scearce, Richard M.; Soderberg, Kelly A.; Cohen, Myron; Kaminga, Gift; Louder, Mark K.; Tran, Lillan M.; Chen, Yue; Cai, Fangping; Chen, Sheri; Moquin, Stephanie; Du, Xiulian; Joyce, Gordon M.; Srivatsan, Sanjay; Zhang, Baoshan; Zheng, Anqi; Shaw, George M.; Hahn, Beatrice H.; Kepler, Thomas B.; Korber, Bette T.M.; Kwong, Peter D.; Mascola, John R.; Haynes, Barton F.

2013-01-01

Current HIV-1 vaccines elicit strain-specific neutralizing antibodies. However, cross-reactive neutralizing antibodies arise in ~20% of HIV-1-infected individuals, and details of their generation could provide a roadmap for effective vaccination. Here we report the isolation, evolution and structure of a broadly neutralizing antibody from an African donor followed from time of infection. The mature antibody, CH103, neutralized ~55% of HIV-1 isolates, and its co-crystal structure with gp120 revealed a novel loop-based mechanism of CD4-binding site recognition. Virus and antibody gene sequencing revealed concomitant virus evolution and antibody maturation. Notably, the CH103-lineage unmutated common ancestor avidly bound the transmitted/founder HIV-1 envelope glycoprotein, and evolution of antibody neutralization breadth was preceded by extensive viral diversification in and near the CH103 epitope. These data elucidate the viral and antibody evolution leading to induction of a lineage of HIV-1 broadly neutralizing antibodies and provide insights into strategies to elicit similar antibodies via vaccination. PMID:23552890

Founders Energy Ltd. 1998 annual report : fiscally prudent, value driven balanced growth strategy

International Nuclear Information System (INIS)

1999-01-01

Founders Energy Ltd is a growth-oriented junior resource company engaged in the acquisition and development of oil and natural gas properties in Alberta, British Columbia and Saskatchewan. The annual review provides details of the company's operations and relevant financial performance during the 1998 fiscal year. In brief, the company realized significant increases in production and reserves, top quartile findings and development costs. It reported significant increases in leverage to natural gas through exploration success at Pouce Coupe and the acquisition of Opal Energy Inc.. It established new core areas in west-central Alberta, Peace River Arch and west-central Saskatchewan. It achieved a better balanced risk profile through geographical diversification and better balance to exploration and development. It increased undeveloped land area to 160,268 net acres and added 11.5 million barrels of established reserves at a finding cost of $ 6.28 per barrel. Financial highlights include increased gross revenue, increased net income per share, and increased shareholders' equity. tabs., figs

International distribution and age estimation of the Portuguese BRCA2 c.156_157insAlu founder mutation

DEFF Research Database (Denmark)

Peixoto, Ana; Santos, Catarina; Pinheiro, Manuela

2011-01-01

The c.156_157insAlu BRCA2 mutation has so far only been reported in hereditary breast/ovarian cancer (HBOC) families of Portuguese origin. Since this mutation is not detectable using the commonly used screening methodologies and must be specifically sought, we screened for this rearrangement...... individuals requesting predictive testing living in France and in the USA, all being Portuguese immigrants. After performing an extensive haplotype study in carrier families, we estimate that this founder mutation occurred 558 ± 215 years ago. We further demonstrate significant quantitative differences...... HBOC families from Portugal or with Portuguese ancestry are specifically tested for this rearrangement....

N.A. Bernstein, the founder of modern biomechanics

Directory of Open Access Journals (Sweden)

Vazha M. Devishvili

2015-12-01

Full Text Available The paper deals with three major periods of scientific work of Nikolai Alexandrovich Bernstein, the outstanding Russian scientist, the founder the motor activity theory of human and animal. In 2016 is the 120th anniversary of Bernstein´s birth. The first period of his scientific activity, from 1922 when Bernstein started his research at the Central Institute of Labour Protection until the middle of the 30s of the 20th century. By this time, he formulated and published the basic principles and ideas of the annular motion control and sensor correction movements of varying complexity and various performance. The second period ends with the fundamental scientific work «On the Construction of Movements» awarded by the USSR State Prize in 1948. The book sums up Bernstein´s more than twenty years of research in the field of biomechanics and physiology of movement. The paper briefly describes the main assumptions of the three chapters of the book. The first chapter «Movements» reveals the evolutionary ideas about the origin of motor function and shaped the principle of the equation of building movements. The second chapter describes five levels with different functionality in varying degrees involved in the implementation of motor actions. The third chapter of the «Development and Decay» deals with the general laws of occurrence and levels of building movements being signs of confirming the level structure of motion in pathology and standards. In 1950-60-ies of the 20th century Bernstein greatly expanded representation of the functional content and neural substrate levels of building movements, detailed the stages and phases of shaping and improvement of motor skills. The author shows the importance of scientific achievements of N.A. Bernstein for modern research in the psychophysiology of movements.

9 July 2008 - Microsoft Co-Founder P. Allen visiting ATLAS control room and underground experimental area with Adviser J. Ellis and IT Department Head W. von Rüden.

CERN Multimedia

Maximilien Brice

2008-01-01

9 July 2008 - Microsoft Co-Founder P. Allen visiting ATLAS control room and underground experimental area with Adviser J. Ellis and IT Department Head W. von Rüden and guided by ATLAS Collaboration Users S. Goldfarb, P. Nevski and L. Price.

A serial founder effect model for human settlement out of Africa.

Science.gov (United States)

Deshpande, Omkar; Batzoglou, Serafim; Feldman, Marcus W; Cavalli-Sforza, L Luca

2009-01-22

The increasing abundance of human genetic data has shown that the geographical patterns of worldwide genetic diversity are best explained by human expansion out of Africa. This expansion is modelled well by prolonged migration from a single origin in Africa with multiple subsequent serial founding events. We discuss a new simulation model for the serial founder effect out of Africa and compare it with results from previous studies. Unlike previous models, we distinguish colonization events from the continued exchange of people between occupied territories as a result of mating. We conduct a search through parameter space to estimate the range of parameter values that best explain key statistics from published data on worldwide variation in microsatellites. The range of parameters we use is chosen to be compatible with an out-of-Africa migration at 50-60Kyr ago and archaeo-ethno-demographic information. In addition to a colonization rate of 0.09-0.18, for an acceptable fit to the published microsatellite data, incorporation into existing models of exchange between neighbouring populations is essential, but at a very low rate. A linear decay of genetic diversity with geographical distance from the origin of expansion could apply to any species, especially if it moved recently into new geographical niches.

Founder effect of a prevalent phenylketonuria mutation in the Oriental population

Energy Technology Data Exchange (ETDEWEB)

Wang, Tao (Baylor College of Medicine, Houston, TX (United States) Chinese Academy of Medical Sciences, Beijing (China)); Okano, Yoshiyuki; Eisensmith, R.C.; Harvey, M.L.; Woo, S.L.C. (Baylor College of Medicine, Houston, TX (United States)); Lo, W.H.Y.; Yuan, Lifang (Chinese Academy of Medical Sciences, Beijing (China)); Huang, Shuzhen; Zeng, Yitao (Shanghai Children' s Hospital (China)); Furuyama, Junichi (Hyogo College of Medicine, Nishinomiya (Japan)); Oura, Toshiaki (Osaka Municipal Rehabilitation Center for the Disabled, Osaka (Japan)); Sommer, S.S. (Mayo Clinic/Foundation, Rochester, MN (United States))

1991-03-15

A missense mutation has been identified in the human phenylalanine hydroxylase Chinese patient with classic phenylketonuria (PKU). A G-to-C transition at the second base of codon 413 in exon 12 of the gene results in the substitution of Pro{sup 413} for Arg{sup 413} in the mutant protein. This mutation (R413P) results in negligible enzymatic activity when expressed in heterologous mammalian cells and is compatible with a classic PKU phenotype in the patient. Population genetic studies reveal that this mutation is tightly linked to restriction fragment length polymorphism haplotype 4, which is the predominant haplotype of the PAH locus in the Oriental population. It accounts for 13.8% of northern Chinese and 27% of Japanese PKU alleles, but it is rare in southern Chinese (2.2%) and is absent in the Caucasian population. The data demonstrate unambiguously that the mutation occurred after racial divergence of Orientals and Caucasians and suggest that the allele has spread throughout the Orient by a founder effect. Previous protein polymorphism studies in eastern Asia have led to the hypothesis that northern Mongoloids represented a founding population in Asia. The results are compatible with this hypothesis in that the PKU mutation might have occurred in northern Mongoloids and subsequently spread to the Chinese and Japanese populations.

Founder effect of a prevalent phenylketonuria mutation in the Oriental population

International Nuclear Information System (INIS)

Wang, Tao; Okano, Yoshiyuki; Eisensmith, R.C.; Harvey, M.L.; Woo, S.L.C.; Lo, W.H.Y.; Yuan, Lifang; Huang, Shuzhen; Zeng, Yitao; Furuyama, Junichi; Oura, Toshiaki; Sommer, S.S.

1991-01-01

A missense mutation has been identified in the human phenylalanine hydroxylase Chinese patient with classic phenylketonuria (PKU). A G-to-C transition at the second base of codon 413 in exon 12 of the gene results in the substitution of Pro 413 for Arg 413 in the mutant protein. This mutation (R413P) results in negligible enzymatic activity when expressed in heterologous mammalian cells and is compatible with a classic PKU phenotype in the patient. Population genetic studies reveal that this mutation is tightly linked to restriction fragment length polymorphism haplotype 4, which is the predominant haplotype of the PAH locus in the Oriental population. It accounts for 13.8% of northern Chinese and 27% of Japanese PKU alleles, but it is rare in southern Chinese (2.2%) and is absent in the Caucasian population. The data demonstrate unambiguously that the mutation occurred after racial divergence of Orientals and Caucasians and suggest that the allele has spread throughout the Orient by a founder effect. Previous protein polymorphism studies in eastern Asia have led to the hypothesis that northern Mongoloids represented a founding population in Asia. The results are compatible with this hypothesis in that the PKU mutation might have occurred in northern Mongoloids and subsequently spread to the Chinese and Japanese populations

[HUGO STEINHAUS--CO-FOUNDER OF THE LWÓW SCHOOL OF MATHEMATICS].

Science.gov (United States)

Wócik, Wiesław

2014-01-01

The paper is dedicated to the presentation of professor Hugo Steinhaus--co-founder of the Lwów School of Mathematics. It is indicated that had it not been for the scholar, the founding and development of the Lwów School of Mathematics would have been almost impossible. The analyses focus on his undertakings during the Lvov period in the early 1920s and those events that preceded the founding of the school (namely Steinhaus's education at the Göttingen University, various meetings and gatherings, discussions, first fascinations and mathematical dissertations). This paper, however, does not look into the scientific output of Steinhaus, only presents his method of scientific work and highlights the strategy that he chose in order to create the scientific community. An attempt has been also made to justify the effectiveness of the adopted strategy by describing the scientific atmosphere of Lvov and intellectual potential of the students of the school. Steinhaus's activities in the 1930s will be only marginally presented with an impact on particularly interesting cooperation with the alumni of the Lwów School of Mathematics--Marek Kac, Stefan Kaczmarz, Paweł Nikliborec and scholars from other fields of science (as part of the process of the application of mathematics).

Molecular and genealogical evidence for a founder effect in Fanconi anemia families of the Afrikaner population of South Africa

Science.gov (United States)

Tipping, A. J.; Pearson, T.; Morgan, N. V.; Gibson, R. A.; Kuyt, L. P.; Havenga, C.; Gluckman, E.; Joenje, H.; de Ravel, T.; Jansen, S.; Mathew, C. G.

2001-01-01

Fanconi anemia (FA) is a rare, genetically heterogeneous autosomal recessive disorder associated with progressive aplastic anemia, congenital abnormalities, and cancer. FA has a very high incidence in the Afrikaner population of South Africa, possibly due to a founder effect. Previously we observed allelic association between polymorphic markers flanking the FA group A gene (FANCA) and disease chromosomes in Afrikaners. We genotyped 26 FA families with microsatellite and single nucleotide polymorphic markers and detected five FANCA haplotypes. Mutation scanning of the FANCA gene revealed association of these haplotypes with four different mutations. The most common was an intragenic deletion of exons 12–31, accounting for 60% of FA chromosomes in 46 unrelated Afrikaner FA patients, while two other mutations accounted for an additional 20%. Screening for these mutations in the European populations ancestral to the Afrikaners detected one patient from the Western Ruhr region of Germany who was heterozygous for the major deletion. The mutation was associated with the same unique FANCA haplotype as in Afrikaner patients. Genealogical investigation of 12 Afrikaner families with FA revealed that all were descended from a French Huguenot couple who arrived at the Cape on June 5, 1688, whereas mutation analysis showed that the carriers of the major mutation were descendants of this same couple. The molecular and genealogical evidence is consistent with transmission of the major mutation to Western Germany and the Cape near the end of the 17th century, confirming the existence of a founder effect for FA in South Africa. PMID:11344308

Design moveleiro: um estudo sobre abordagens de publicações internacionais por meio de revisão sistemática

Directory of Open Access Journals (Sweden)

Gabriel Bergmann Borges Vieira

2016-08-01

Full Text Available A competitividade no setor moveleiro e a busca por diferenciação amplia a importância do design como subsídio para aumentar a performance empresarial. As diferentes abordagens de design moveleiro, aproximando-se às variadas áreas do conhecimento como gestão, comunicação e engenharia impulsiona para a busca por compreender de quais as características predominantes em estudos publicados nos periódicos acadêmicos em nível internacional. Este trabalho tem como objetivo de pesquisa analisar as principais abordagens dos estudos sobre Design Moveleiro. A metodologia de pesquisa utilizada foi a revisão sistemática da literatura uma vez que viabiliza conhecimento acerca do tema de forma estruturada, clara e objetiva. Como resultado, o trabalho apresenta as principais publicações nos últimos cinco anos, as características desses estudos e os focos de conteúdos abordados, permitindo a compreensão do estado da arte de pesquisas sobre o Design Moveleiro, especialmente relacionados com a busca por performance empresarial.

A Mayan founder mutation is a common cause of deafness in Guatemala.

Science.gov (United States)

Carranza, C; Menendez, I; Herrera, M; Castellanos, P; Amado, C; Maldonado, F; Rosales, L; Escobar, N; Guerra, M; Alvarez, D; Foster, J; Guo, S; Blanton, S H; Bademci, G; Tekin, M

2015-09-08

Over 5% of the world's population has varying degrees of hearing loss. Mutations in GJB2 are the most common cause of autosomal recessive non-syndromic hearing loss (ARNHL) in many populations. The frequency and type of mutations are influenced by ethnicity. Guatemala is a multi-ethnic country with four major populations: Maya, Ladino, Xinca, and Garifuna. To determine the mutation profile of GJB2 in a ARNHL population from Guatemala, we sequenced both exons of GJB2 in 133 unrelated families. A total of six pathogenic variants were detected. The most frequent pathogenic variant is c.131G>A (p.Trp44*) detected in 21 of 266 alleles. We show that c.131G>A is associated with a conserved haplotype in Guatemala suggesting a single founder. The majority of Mayan population lives in the west region of the country from where all c.131G>A carriers originated. Further analysis of genome-wide variation of individuals carrying the c.131G>A mutation compared with those of Native American, European, and African populations shows a close match with the Mayan population. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Genome-wide association study of pre-harvest sprouting resistance in Chinese wheat founder parents

Directory of Open Access Journals (Sweden)

Yu Lin

2017-07-01

Full Text Available Abstract Pre-harvest sprouting (PHS is a major abiotic factor affecting grain weight and quality, and is caused by an early break in seed dormancy. Association mapping (AM is used to detect correlations between phenotypes and genotypes based on linkage disequilibrium (LD in wheat breeding programs. We evaluated seed dormancy in 80 Chinese wheat founder parents in five environments and performed a genome-wide association study using 6,057 markers, including 93 simple sequence repeat (SSR, 1,472 diversity array technology (DArT, and 4,492 single nucleotide polymorphism (SNP markers. The general linear model (GLM and the mixed linear model (MLM were used in this study, and two significant markers (tPt-7980 and wPt-6457 were identified. Both markers were located on Chromosome 1B, with wPt-6457 having been identified in a previously reported chromosomal position. The significantly associated loci contain essential information for cloning genes related to resistance to PHS and can be used in wheat breeding programs.

TP53 mutation p.R337H in gastric cancer tissues of a 12-year-old male child - evidence for chimerism involving a common mutant founder haplotype: case report

International Nuclear Information System (INIS)

Silva, Edaise M da; W Achatz, Maria Isabel; Martel-Planche, Ghyslaine; Montagnini, André L; Olivier, Magali; Prolla, Patricia A; Hainaut, Pierre; Soares, Fernando A

2011-01-01

Gastric adenocarcinoma is rare in children and adolescents, with about 17 cases under age 21 in the world's literature. We report a case of invasive well-differentiated metastatic gastric cancer in a Brazilian 12-year-old boy without documented familial history of cancer. The patient, diagnosed with metastatic disease, died seven months after surgery. DNA from intra-surgical specimens revealed a TP53 mutation at codon 337 (p.R337H) in samples with neoplastic cells (dysplasia, tumor and metastasis) but not in non-transformed cells (incomplete intestinal metaplasia and non-involved celiac lymph node). In all mutation-positive tissues, p.R337H occurred on the same background, a founder allele identified by a specific haplotype previously described in Brazilian Li-Fraumeni syndrome patients. The same mutant haplotype, corresponding to a founder mutation present in 0.3% of the general population in Southern Brazil, was found in the genome of the father. Presence of this inherited haplotype in the tumor as well as in the father's germline, suggests a rare case of microchimerism in this patient, who may have harbored a small number of mutant cells originating in another individual, perhaps a dizygotic twin that died early in gestation. This case represents one of the earliest ages at diagnosis of gastric cancer ever reported. It shows that cancer inheritance can occur in the absence of an obvious germline mutation, calling for caution in assessing early cancers in populations with common founder mutations such as p.R337H in Southern Brazil

Jean-Alfred Fournier - the founder of the European venereology and dermatology (on the one hundredth death anniversary

Directory of Open Access Journals (Sweden)

O. A. Kisteneva

2014-01-01

Full Text Available The article presents a life story of a great French dermatologist and venereologist, one of the founders of the theory of syphilis Jean-Alfred Fournier (1832-1914. It provides data on the published works by Jean-Alfred Fournier, some of which earned him a doctoral degree. It also provides data on Fournier’s election as a member of the French Academy of Medicine in 1879 as well as on the founding of the French Society of Dermatology and Syphiligraphy by Fournier and other French dermatologists in 1889. The article defines the contribution made by Fournier to the development of venereology and practical medicine in the second half of the 19th century and early 20th century.

Is the c.3G>C mutation in the succinate dehydrogenase subunit D (SDHD) gene due to a founder effect in Chinese head and neck paraganglioma patients?

Science.gov (United States)

Zha, Yang; Chen, Xing-ming; Lam, Ching-wan; Lee, Soo-chin; Tong, Sui-fan; Gao, Zhi-qiang

2011-08-01

Three Chinese patients with head and neck paragangliomas have been reported to carry the c.3G>C mutation in the succinate dehydrogenase subunit D (SDHD) gene. In addition, in our hospital, two further patients were identified who have the same mutation. It is unclear whether the c.3G>C mutation in Chinese patients is a recurrent mutation or if it is due to a founder effect. We conducted haplotype analysis on these patients to answer this question. Individual case-control study. Germ-line mutations were confirmed in the patients and their families examined in this study using direct sequencing. We also constructed and analyzed haplotypes in four Chinese families. Genotype frequencies were compared to the control group. Three of four families shared the same haplotype, which rarely occurred in the control group. The last family shared a very short area on the physical map with the other three families. There is a founder effect in Chinese head and neck paraganglioma patients carrying the SDHD c.3G>C mutation. Copyright © 2011 The American Laryngological, Rhinological, and Otological Society, Inc.

Uudised : Tüüri esiettekanne Frankfurdis. Corelli Musicult "Jõulud mõisas"

Index Scriptorium Estoniae

2006-01-01

22., 23. ja 24. nov. Frankfurdi Alte Operis esiettekandele tulevast Erkki-Sven Tüüri uuest "Klaverikontserdist". Eesti-Tšiili trio Raivo Tafenau - Meelis Vind - Ricardo Padilla kontsertidest sarja "Mõisaromantika" raames 25. nov. Taagepera lossis Valgamaal, 26. nov. Tõstamaa mõisas Pärnumaal ja 16. dets. Vihterpalu mõisas Harjumaal. Hans Neuenfelsi lavastatud Mozarti ooperist "Idemeneo" Deutsche Operis Berliinis. Inglise ansambli Procol Harumi hiti "A Whiter Shade of Pale" autoriõigustest

Isolation mediates persistent founder effects on zooplankton colonisation in new temporary ponds

Science.gov (United States)

Badosa, Anna; Frisch, Dagmar; Green, Andy J.; Rico, Ciro; Gómez, Africa

2017-03-01

Understanding the colonisation process in zooplankton is crucial for successful restoration of aquatic ecosystems. Here, we analyzed the clonal and genetic structure of the cyclical parthenogenetic rotifer Brachionus plicatilis by following populations established in new temporary ponds during the first three hydroperiods. Rotifer populations established rapidly after first flooding, although colonisation was ongoing throughout the study. Multilocus genotypes from 7 microsatellite loci suggested that most populations (10 of 14) were founded by few clones. The exception was one of the four populations that persisted throughout the studied hydroperiods, where high genetic diversity in the first hydroperiod suggested colonisation from a historical egg bank, and no increase in allelic diversity was detected with time. In contrast, in another of these four populations, we observed a progressive increase of allelic diversity. This population became less differentiated from the other populations suggesting effective gene flow soon after its foundation. Allelic diversity and richness remained low in the remaining two, more isolated, populations, suggesting little gene flow. Our results highlight the complexity of colonisation dynamics, with evidence for persistent founder effects in some ponds, but not in others, and with early immigration both from external source populations, and from residual, historical diapausing egg banks.

George de Hevesy (1885-1966). Discoverer of hafnium, founder of radioanalytical chemistry and X-ray fluorescence analysis and father of nuclear medicine

International Nuclear Information System (INIS)

Niese, Siegfried

2017-01-01

George de Hevesy known as discoverer of hafnium, founder of radioanalytical chemistry and X-ray fluorescence analysis and father of nuclear medicine has done important research work in inorganic, physical and radioanalytical and physiological chemistry as well as in geochemistry, radiation biology and medicine. When he must flee for political reasons from a country he must change his colleagues, his equipments, and the topic of his work. It is extremely surprising that he could receive important results under such circumstances even at an advanced age. (author)

Valimissüsteemi tuleks muuta / Rein Taagepera

Index Scriptorium Estoniae

Taagepera, Rein, 1933-

2007-01-01

Autor on seisukohal, et praegune Riigikogu valimise süsteem on liiga keeruline ja seda tuleks lihtsustada. Ta vaatleb, mis juhtuks siis, kui Eesti oleks jagatud 101 valimisringkonnaks, kus enim hääli saanud kandidaat võidab, või kui Eesti oleks üksainus valimispiirkond, kus 101 enim hääli saanud kandidaati võidavad

Peaks Venemaa tükeldama / Rein Taagepera

Index Scriptorium Estoniae

Taagepera, Rein, 1933-

2001-01-01

Ettekanne "Should Russia Break Up" Ameerika Politoloogia Ühingu aastakoosolekul Washingtonis 3.septembril 2000.a. Venemaa majanduslik ja poliitiline olukord seoses kolme revolutsiooni toimumisega: demokratiseerimine, turumajanduse sissetoomine ning dekoloniseerimine. Venemaa territoriaalse arengu võimalused

[On the founders of the Institute of Mathematics and Physics, University of Bahia].

Science.gov (United States)

Dias, A L

The reduced number of female students of mathematics at the University of Bahia School of Philosophy (Faculdade de Filosofia, Universidade da Bahia - FF/UBa) is quite surprising. To date, they are concentrated in areas traditionally viewed as feminine whereas men predominate in the mathematical fields. I have examined interview data from a few women who graduated in mathematics and went on to teach at the University of Bahia School of Mathematics (Faculdade de Filosofia - FF) and at the Institute of Mathematics and Physics (Instituto de Matemática e Física - IMF), where they were soon to outnumber men and constitute the majority of the mathematics teaching staff. In this study, I have investigated the course of their careers over time: from their early student days, through their time as teaching assistants and professors, and finally as founders of the Institute of Mathematics and Physics, in 1960. Special reference is made to Martha Maria de Souza Dantas, organizer of the I Brazilian Conference on Mathematics Teaching, an event which has provided the groundwork for what was to become the Institute (IMF); and to Arlete Cerqueira Lima, the mastermind behind its creation.

Nukuleka as a founder colony for West Polynesian settlement : new insights from recent excavations

International Nuclear Information System (INIS)

Burley, D.V.; Barton, A.; Dickinson, W.R.; Connaughton, S.P.; Tache, K.

2010-01-01

Previous archaeological studies in the village of Nukuleka, Tongatapu, Kingdom of Tonga proposed it as a founder colony for Polynesia. Additional excavation and survey were undertaken in 2007 to evaluate this status further and to gain new insight into the nature of the occupation and its role in the subsequent peopling of west Polynesia. A review of this project and its findings are presented. Decorated ceramics of western Lapita style, the presence of tan paste ceramics foreign to Tonga, and new radiocarbon dates support Nukuleka as a site of first landfall in the interval 2850 to 2900 cal BP. The ceramic assemblage is distinct from west and central Fiji, and an independent origin for Fijian and Polynesian colonizers is argued. The settlement quickly expanded on the Nukuleka Peninsula to 20 ha or more in size, forming a central place for the eastern Lapita province in Tonga, Samoa and the Lau islands of Fiji. Nukuleka, we believe, provides insight into the cultural if not biological base from which ancestral Polynesian society emerged. (author). 35 refs., 11 figs., 3 tabs.

The CHEK2 del5395 is a founder mutation without direct effects for cancer risk in the latvian population

Directory of Open Access Journals (Sweden)

Plonis J

2015-12-01

Full Text Available Our objective was to determine: 1 whether the checkpoint kinase 2 (CHEK2 del5395 (g.27417113-27422508 del, NC_000022.11 is a founder mutation in the Latvian population, 2 if there is an association between CHEK2 del5395 mutation and cancer risk, and 3 and whether the CHEK2 del5395 mutation impacts cancer predisposition in Chernobyl disaster liquidators (the civil and military personnel who were called upon to deal with consequences of the 1986 nuclear disaster as well as geriatric populations. We recruited 438 breast cancer patients, 568 colorectal cancer patients, 399 ovarian cancer patients, 419 prostate cancer patients, 526 healthy blood donors, 480 Chernobyl disaster liquidators and 444 geriatric cancer-free participants. DNA samples were isolated from blood samples and subjected to multiplex polymerase chain reaction (PCR. The truncation of del5395 was estimated by fragment size of the multiplex PCR.All groups were compared to the healthy blood donors using Fisher’s exact test. All p values were two-sided and the odds ratios (OR calculated by two-by-two table. In cancer groups, the del5395 mutation was most frequently observed in the ovarian cancer group (1.00%, OR = 1.32. In control groups, the del5395 mutation was most frequent (0.76% in the healthy donors, which exceeded its frequency in the Chernobyl liquidators group and the geriatric group by 0.01 and 0.08%, respectively. For all groups, the OR appeared to be >1 only in ovarian cancer patients. However, OR rates showed no statistical significance in either cancer or control groups, with the p value fluctuating within the range of 0.39-1.00. The CHEK2 gene del5395 is a founder mutation in the Latvian population, which, however, does not have a direct impact on genetic predisposition toward colorectal, breast, ovarian and prostate cancer.

Os usos sociais do dinheiro em circuitos filantrópicos: o caso das "publicações de rua"

Directory of Open Access Journals (Sweden)

Ariel Wilkis

2008-04-01

Full Text Available A partir de um estudo de caso centrado em uma organização que edita uma revista vendida por pessoas "sem teto" na cidade de Buenos Aires, me interrogo sobre os usos sociais do dinheiro em circuitos filantrópicos. Ao seguir a polêmica entre dinheiro e dom, que está no centro das discussões da antropologia e da sociologia, enfoco duas questões: a o papel do dinheiro para demarcar os limites entre as "transações mercantis" e as "circulações de dons"; b a relação entre dinheiro e moral. O trabalho de campo consistiu em uma etnografia das transações entre os vendedores e os compradores desta publicação.Based on a case study of an organization responsible for publishing a magazine sold to ‘homeless’ people in Buenos Aires, I examine the social uses of money in philanthropic circles. Turning to the polemic between money and gift at the centre of discussions in anthropology and sociology, I focus on two questions: a the role of money in demarcating the limits between ‘market transactions’ and ‘gift circulations’; b the relation between money and morality. Fieldwork involved an ethnographic study of the transactions between the sellers and buyers of this publication.

Cost effectiveness of population based BRCA1 founder mutation testing in Sephardi Jewish women.

Science.gov (United States)

Patel, Shreeya; Legood, Rosa; Evans, D Gareth; Turnbull, Clare; Antoniou, Antonis C; Menon, Usha; Jacobs, Ian; Manchanda, Ranjit

2018-04-01

Population-based BRCA1/BRCA2 founder-mutation testing has been demonstrated as cost effective compared with family history based testing in Ashkenazi Jewish women. However, only 1 of the 3 Ashkenazi Jewish BRCA1/BRCA2 founder mutations (185delAG[c.68_69delAG]), 5382insC[c.5266dupC]), and 6174delT[c.5946delT]) is found in the Sephardi Jewish population (185delAG[c.68_69delAG]), and the overall prevalence of BRCA mutations in the Sephardi Jewish population is accordingly lower (0.7% compared with 2.5% in the Ashkenazi Jewish population). Cost-effectiveness analyses of BRCA testing have not previously been performed at these lower BRCA prevalence levels seen in the Sephardi Jewish population. Here we present a cost-effectiveness analysis for UK and US populations comparing population testing with clinical criteria/family history-based testing in Sephardi Jewish women. A Markov model was built comparing the lifetime costs and effects of population-based BRCA1 testing, with testing using family history-based clinical criteria in Sephardi Jewish women aged ≥30 years. BRCA1 carriers identified were offered magnetic resonance imaging/mammograms and risk-reducing surgery. Costs are reported at 2015 prices. Outcomes include breast cancer, ovarian cancer, and excess deaths from heart disease. All costs and outcomes are discounted at 3.5%. The time horizon is lifetime, and perspective is payer. The incremental cost-effectiveness ratio per quality-adjusted life-year was calculated. Parameter uncertainty was evaluated through 1-way and probabilistic sensitivity analysis. Population testing resulted in gain in life expectancy of 12 months (quality-adjusted life-year = 1.00). The baseline discounted incremental cost-effectiveness ratio for UK population-based testing was £67.04/quality-adjusted life-year and for US population was $308.42/quality-adjusted life-year. Results were robust in the 1-way sensitivity analysis. The probabilistic sensitivity analysis showed 100% of

Fragile X founder effect and distribution of CGG repeats among the mentally retarded population of Andalusia, South Spain

Directory of Open Access Journals (Sweden)

Yolanda de Diego

2002-01-01

Full Text Available Fragile X syndrome is the most common inherited form of mental retardation. We investigated the prevalence of the Fragile X syndrome in the population with mental retardation of unknown etiology in Andalusia, South Spain. We analyzed 322 unrelated patients (280 males and 42 females, and found a fragile X syndrome frequency of 6.5%. Among the non-fragile X chromosomes, the 29 CGG repeat was the most common allele. At the linked microsatellite DXS548 locus, we found a new allele which we called "allele 10" (17 CA. Similar to other south European populations, allele 2 (25 CA at the DXS548 locus and the fragile X allele were in linkage disequilibrium supporting the idea of a common founder chromosome predisposing to the CGG expansion.

The long-lasting customs (longa consuetudine and the public interests (utilitas publica

Directory of Open Access Journals (Sweden)

Sič Magdolna

2011-01-01

Full Text Available In the process of creating the Roman Empire as well as thereafter during the struggle for its existence, the following question emerges: to which extent should be the acceding nations allowed to practice their deeply embedded customary rules? This question is important also nowadays in times of creation of the European Union and its unified legal system. In terms of the use of customs Rome has been changing its attitude depending on important changes in the society. In times of a rise, during the period of Republic, Rome was deciding on whether it will allow or forbid the acceding nations to continue living by their own customs and religious rules. Later, when the roman citizenship has been given to all inhabitants of the Empire by Caracalla's Edict (in the 212. year, a liberal approach has been taken. In the constitution of Alexander Sever, as well as in the fragments of the classical lawyers one can read about the obligation of the judge to take into account the customs. However, when the Empire got into a serious crisis and barbarian people came onto the roman land, a general boundary has been set towards the use of longlasting customs: these customs could be used, and potentially even have the force of a law, as long as they did not jeopardize the interests of the Empire (utilitas publica. The analyzed rules on the question can the potential future heirs dispose with the future heritage (the goods of a living person - bonis viventis in the classical, post-classical and Justinian's law, points onto the fact that the postclassical cutomary rules, that were not in conflict with the interests of the Empire, contributed even to the changes of the rules of the classical roman law. In the taken example, the classical rule according to which the disposal with future heritage is null and void, is modified under the influence of a German custom in a way that, property division and disposal with the divided property by future heirs was allowed

The initial antibody response to HIV-1: induction of ineffective early B cell responses against GP41 by the transmitted/founder virus

Energy Technology Data Exchange (ETDEWEB)

Chavez, Leslie L [Los Alamos National Laboratory; Perelson, Alan [Los Alamos National Laboratory

2008-01-01

A window of opportunity for immune responses to extinguish HIV -1 exists from the moment of transmission through establishment of the latent pool of HIV -I-infected cells. A critical time to study the initial immune responses to the transmitted/founder virus is the eclipse phase of HIV-1 infection (time from transmission to the first appearance of plasma virus) but, to date, this period has been logistically difficult to analyze. Studies in non-human primates challenged with chimeric simianhuman immunodeficiency virus have shown that neutralizing antibodies, when present at the time of infection, can prevent virus infection.

Nonsyndromic retinitis pigmentosa is highly prevalent in the Jerusalem region with a high frequency of founder mutations.

Science.gov (United States)

Sharon, Dror; Banin, Eyal

2015-01-01

Nonsyndromic retinitis pigmentosa (RP) is the most common inherited retinal degeneration, and prevalence of the disease has been reported in populations of American and European origin with a relatively low consanguinity rate. Our aim was to determine the prevalence of nonsyndromic RP in the Jerusalem region, which has a population of about 1 million individuals with a high rate of consanguinity. The patients' clinical data included eye exam findings (visual acuity, anterior segment, and funduscopy) as well as electroretinographic (ERG) testing results under scotopic and photopic conditions. Mutation analysis on a subgroup of patients was performed mainly with candidate gene analysis and homozygosity mapping. We evaluated the medical records of patients with degenerative retinal diseases residing in the Jerusalem region who were examined over the past 20 years in a large tertiary medical center. A total of 453 individuals affected with nonsyndromic RP were diagnosed at our center, according to funduscopic findings and ERG testing. Based on the estimated population size of 945,000 individuals who reside in the vicinity of Jerusalem, the prevalence of nonsyndromic RP in this region is 1:2,086. The prevalence of RP was higher among Arab Muslims (1:1,798) compared to Jews (1:2,230), mainly due to consanguineous marriages that are more common in the Arab Muslim population. To identify the genetic causes of RP in our cohort, we recruited 383 patients from 183 different families for genetic analysis: 70 with autosomal recessive (AR) inheritance, 15 with autosomal dominant, 86 isolate cases, and 12 with an X-linked inheritance pattern. In 64 (35%) of the families, we identified the genetic cause of the disease, and we revised the inheritance pattern of 20 isolate cases to the AR pattern; 49% of the families in our cohort had AR inheritance. Interestingly, in 42 (66%) of the genetically identified families, the cause of disease was a founder mutation. Previous studies

The Slavic NBN Founder Mutation: A Role for Reproductive Fitness?

Directory of Open Access Journals (Sweden)

Eva Seemanova

Full Text Available The vast majority of patients with Nijmegen Breakage Syndrome (NBS are of Slavic origin and carry a deleterious deletion (c.657del5; rs587776650 in the NBN gene on chromosome 8q21. This mutation is essentially confined to Slavic populations and may thus be considered a Slavic founder mutation. Notably, not a single parenthood of a homozygous c.657del5 carrier has been reported to date, while heterozygous carriers do reproduce but have an increased cancer risk. These observations seem to conflict with the considerable carrier frequency of c.657del5 of 0.5% to 1% as observed in different Slavic populations because deleterious mutations would be eliminated quite rapidly by purifying selection. Therefore, we propose that heterozygous c.657del5 carriers have increased reproductive success, i.e., that the mutation confers heterozygote advantage. In fact, in our cohort study of the reproductive history of 24 NBS pedigrees from the Czech Republic, we observed that female carriers gave birth to more children on average than female non-carriers, while no such reproductive differences were observed for males. We also estimate that c.657del5 likely occurred less than 300 generations ago, thus supporting the view that the original mutation predated the historic split and subsequent spread of the 'Slavic people'. We surmise that the higher fertility of female c.657del5 carriers reflects a lower miscarriage rate in these women, thereby reflecting the role of the NBN gene product, nibrin, in the repair of DNA double strand breaks and their processing in immune gene rearrangements, telomere maintenance, and meiotic recombination, akin to the previously described role of the DNA repair genes BRCA1 and BRCA2.

Posterior microphthalmia and nanophthalmia in Tunisia caused by a founder c.1059_1066insC mutation of the PRSS56 gene.

Science.gov (United States)

Said, Mariem Ben; Chouchène, Ebtissem; Salem, Salma Ben; Daoud, Kods; Largueche, Leila; Bouassida, Walid; Benzina, Zeineb; Ayadi, Hammadi; Söderkvist, Peter; Matri, Leila; Hmani-Aifa, Mounira

2013-10-10

Congenital microphthalmia (CMIC) is a common developmental ocular disorder characterized by a small, and sometimes malformed, eye. Posterior microphthalmia (PM) and nanophthalmia are two rare subtypes of isolated CMIC characterized by extreme hyperopia due to short axial length and elevated lens/eye volume ratio. While nanophthalmia is associated with a reduced size in both anterior and posterior segments, PM involves a normal-size anterior chamber but a small posterior segment. Several genes encoding transcription and non-transcription regulators have been identified in different forms of CMIC. MFRP gene mutations have, for instance, been associated with nanophthalmia, and mutations in the recently identified PRSS56 gene have been linked to PM. So far, these two forms of CMIC have been associated with 9 mutations in PRSS56. Of particular interest, a c.1059_1066insC mutation has recently been reported in four Tunisian families with isolated PM and one Tunisian family with nanophthalmia. Here, we performed a genome-wide scan using a high density single nucleotide polymorphism (SNP) array 50 K in a large consanguineous Tunisian family (PM7) affected with PM and identified the same causative disease mutation. A total of 24 polymorphic markers spanning the PRSS56 gene in 6 families originating from different regions of Tunisia were analyzed to investigate the origin of the c.1059_1066insC mutation and to determine whether it arose in a common ancestor. A highly significant disease-associated haplotype, spanning across the 146 kb of the 2q37.1 chromosome, was conserved in those families, suggesting that c.1059_1066insC arose from a common founder. The age of the mutation in this haplotype was estimated to be around 1,850 years. The identification of such 'founder effects' may greatly simplify diagnostic genetic screening and lead to better prognostic counseling. © 2013 Elsevier B.V. All rights reserved.

The science and art of learning about cultures: Descriptions, explanations, and reflections In conversation with Sri Sri Ravi Shankar, Founder, Art of Living

Directory of Open Access Journals (Sweden)

Ritu Tripathi

2014-06-01

Full Text Available National cultural differences pose major obstacles to global business expansion. Managers, therefore, seek to learn more about cultures. Conventional managerial learning mostly draws from descriptive scientific models which have potential drawbacks such as unidimensionality, decontextualisation, and culture-level information. Explanatory models of cultural psychology can help overcome these limitations. Further, insights from a cross-culturally fluent authority provide reflective learnings. Toward this end, I engage in a conversation with Sri Sri Ravi Shankar, the founder of the Art of Living organization, on issues related to cultural identity in the global workplace in the Indian context.

Master John of Arderne (1307-1380): a founder of modern surgery.

Science.gov (United States)

Pearn, John

2012-01-01

John of Arderne (1307-1380) was one founder of surgery as the profession is known today. He was the first English surgeon of whom biographic details survive. Born on the Arderne Estates at Newark, England, he served as a military surgeon in France in campaigns where gunpowder was used in combat for the first time. His best-known work, the Practica (De Arte Phisicali et de Cirurgia), formed the basis of practical surgical teaching in the medical schools of medieval Europe. Biographic research of primary and secondary archives and documents. John of Arderne's surgical practice was undertaken against a background of turbulent political, military and medical events. He survived the Black Death (1347) and its cyclical recurrences. He lived through the turbulent reigns of Edward II and Edward III and practised in London in the decades preceding the simmering unrest which preceded the Peasant's Revolt of 1381. Surgical and medical practice in the late Middle Ages was enmeshed in astrological beliefs. It was greatly influenced by church doctrine of disease causation. In this paper, the known details of John of Arderne's life are placed in the perspective of these societal and professional influences. He is one of several pre-Renaissance European doctors who were the first to challenge the received medical lore of Galen and later Arabic surgeons. Writing when he was 70 years of age, John of Arderne was the first to advocate that surgeons should trust their own clinical experience 'Wele ymagynyng subtile things' rather than following the directions of others, even including those advocated by himself. © 2011 The Author. ANZ Journal of Surgery © 2011 Royal Australasian College of Surgeons.

Counting the founders: the matrilineal genetic ancestry of the Jewish Diaspora.

Science.gov (United States)

Behar, Doron M; Metspalu, Ene; Kivisild, Toomas; Rosset, Saharon; Tzur, Shay; Hadid, Yarin; Yudkovsky, Guennady; Rosengarten, Dror; Pereira, Luisa; Amorim, Antonio; Kutuev, Ildus; Gurwitz, David; Bonne-Tamir, Batsheva; Villems, Richard; Skorecki, Karl

2008-04-30

The history of the Jewish Diaspora dates back to the Assyrian and Babylonian conquests in the Levant, followed by complex demographic and migratory trajectories over the ensuing millennia which pose a serious challenge to unraveling population genetic patterns. Here we ask whether phylogenetic analysis, based on highly resolved mitochondrial DNA (mtDNA) phylogenies can discern among maternal ancestries of the Diaspora. Accordingly, 1,142 samples from 14 different non-Ashkenazi Jewish communities were analyzed. A list of complete mtDNA sequences was established for all variants present at high frequency in the communities studied, along with high-resolution genotyping of all samples. Unlike the previously reported pattern observed among Ashkenazi Jews, the numerically major portion of the non-Ashkenazi Jews, currently estimated at 5 million people and comprised of the Moroccan, Iraqi, Iranian and Iberian Exile Jewish communities showed no evidence for a narrow founder effect, which did however characterize the smaller and more remote Belmonte, Indian and the two Caucasus communities. The Indian and Ethiopian Jewish sample sets suggested local female introgression, while mtDNAs in all other communities studied belong to a well-characterized West Eurasian pool of maternal lineages. Absence of sub-Saharan African mtDNA lineages among the North African Jewish communities suggests negligible or low level of admixture with females of the host populations among whom the African haplogroup (Hg) L0-L3 sub-clades variants are common. In contrast, the North African and Iberian Exile Jewish communities show influence of putative Iberian admixture as documented by mtDNA Hg HV0 variants. These findings highlight striking differences in the demographic history of the widespread Jewish Diaspora.

Interview with Mia Katigbak (co-founder and artistic producing director of NAATCO).Breaking Racial and Ethnic Stereotypes on the American Stage: National Asian American Theatre Company’s 25th Anniversary

OpenAIRE

Medalle, Rovie Herrera

2016-01-01

Entretien avec Mia Katigbak, co-fondatrice et directrice artistique de NAATCO (National Asian American Theatre Company). L’entretien, réalisé en août 2015, consistaient en un échange de courriels Interview with Mia Katigbak, co-founder and Artistic Producing Director of NAATCO (National Asian American Theatre Company). The interview was conducted by emails in August 2015

Comprehensive population-wide analysis of Lynch syndrome in Iceland reveals founder mutations in MSH6 and PMS2.

Science.gov (United States)

Haraldsdottir, Sigurdis; Rafnar, Thorunn; Frankel, Wendy L; Einarsdottir, Sylvia; Sigurdsson, Asgeir; Hampel, Heather; Snaebjornsson, Petur; Masson, Gisli; Weng, Daniel; Arngrimsson, Reynir; Kehr, Birte; Yilmaz, Ahmet; Haraldsson, Stefan; Sulem, Patrick; Stefansson, Tryggvi; Shields, Peter G; Sigurdsson, Fridbjorn; Bekaii-Saab, Tanios; Moller, Pall H; Steinarsdottir, Margret; Alexiusdottir, Kristin; Hitchins, Megan; Pritchard, Colin C; de la Chapelle, Albert; Jonasson, Jon G; Goldberg, Richard M; Stefansson, Kari

2017-05-03

Lynch syndrome, caused by germline mutations in the mismatch repair genes, is associated with increased cancer risk. Here using a large whole-genome sequencing data bank, cancer registry and colorectal tumour bank we determine the prevalence of Lynch syndrome, associated cancer risks and pathogenicity of several variants in the Icelandic population. We use colorectal cancer samples from 1,182 patients diagnosed between 2000-2009. One-hundred and thirty-two (11.2%) tumours are mismatch repair deficient per immunohistochemistry. Twenty-one (1.8%) have Lynch syndrome while 106 (9.0%) have somatic hypermethylation or mutations in the mismatch repair genes. The population prevalence of Lynch syndrome is 0.442%. We discover a translocation disrupting MLH1 and three mutations in MSH6 and PMS2 that increase endometrial, colorectal, brain and ovarian cancer risk. We find thirteen mismatch repair variants of uncertain significance that are not associated with cancer risk. We find that founder mutations in MSH6 and PMS2 prevail in Iceland unlike most other populations.

Comparison of semiempirical formulae for alpha decay half-lives

International Nuclear Information System (INIS)

Poenaru, D.N.; Ivascu, M.; Sandulesku, A.

1983-01-01

The semiempirical relationships given by Froeman, Wapstra et al., Viola and Seaborg, Hornshoj et al., Taagepera and Nurmia, Keller and Munzel for alpha decay half-lives are compared with experimental results and with a new formula derived by the authors form the fission theory of alpha decay in even-even, odd-even, even-odd and odd-odd nuclei. By taking into consideration the shell effects, the new formula allows one to obtain a better agreement with experimental data, even in the neighbourhood of the magic numbers

Willet M. Hays, great benefactor to plant breeding and the founder of our association.

Science.gov (United States)

Troyer, A F; Stoehr, H

2003-01-01

Willet M. Hays was a great benefactor to plant breeding and the founder of the American Genetic Association (AGA). We commemorate the AGA's centennial. We mined university archives, U.S. Department of Agriculture (USDA) yearbooks, plant breeding textbooks, scientific periodicals, and descendants for information. Willet Hays first recognized the individual plant as the unit of selection and started systematic pure-line selection and progeny tests in 1888. He developed useful plant breeding methods. He selected superior flax (Linum usitatissimum L.), wheat (Triticum vulgare L.), corn (Zea mays L.), barley (Hordeum vulgare L.), and oat (Avena sativa L.) varieties, and discovered Grimm alfalfa (Medicago sativa L.); all became commercially important. He initiated branch stations for better performance testing. Willet Hays befriended colleagues in other universities, in federal stations, in a London conference, and in Europe. He gathered and spread the scientific plant breeding gospel. He also improved rural roads and initiated animal breeding records and agricultural economics records. He started the AGA in 1903, serving as secretary for 10 years. He became assistant secretary of agriculture in 1904. He introduced the project system for agricultural research. He authored or coauthored the Nelson Amendment, the Smith-Lever Act, the Smith-Hughes Act, and the protocol leading to the United Nations Food and Agriculture Organization-all involved teaching agricultural practices that improved the world.

A founder mutation in LEPRE1 carried by 1.5% of West Africans and 0.4% of African Americans causes lethal recessive osteogenesis imperfecta.

Science.gov (United States)

Cabral, Wayne A; Barnes, Aileen M; Adeyemo, Adebowale; Cushing, Kelly; Chitayat, David; Porter, Forbes D; Panny, Susan R; Gulamali-Majid, Fizza; Tishkoff, Sarah A; Rebbeck, Timothy R; Gueye, Serigne M; Bailey-Wilson, Joan E; Brody, Lawrence C; Rotimi, Charles N; Marini, Joan C

2012-05-01

Deficiency of prolyl 3-hydroxylase 1, encoded by LEPRE1, causes recessive osteogenesis imperfecta (OI). We previously identified a LEPRE1 mutation exclusively in African Americans and contemporary West Africans. We hypothesized that this allele originated in West Africa and was introduced to the Americas with the Atlantic slave trade. We aimed to determine the frequency of carriers for this mutation among African Americans and West Africans, and the mutation origin and age. Genomic DNA was screened for the mutation using PCR and restriction digestion, and a custom TaqMan genomic single-nucleotide polymorphism assay. The mutation age was estimated using microsatellites and short tandem repeats spanning 4.2 Mb surrounding LEPRE1 in probands and carriers. Approximately 0.4% (95% confidence interval: 0.22-0.68%) of Mid-Atlantic African Americans carry this mutation, estimating recessive OI in 1/260,000 births in this population. In Nigeria and Ghana, 1.48% (95% confidence interval: 0.95-2.30%) of unrelated individuals are heterozygous carriers, predicting that 1/18,260 births will be affected with recessive OI, equal to the incidence of de novo dominant OI. The mutation was not detected in Africans from surrounding countries. All carriers shared a haplotype of 63-770 Kb, consistent with a single founder for this mutation. Using linkage disequilibrium analysis, the mutation was estimated to have originated between 650 and 900 years before present (1100-1350 CE). We identified a West African founder mutation for recessive OI in LEPRE1. Nearly 1.5% of Ghanians and Nigerians are carriers. The estimated age of this allele is consistent with introduction to North America via the Atlantic slave trade (1501-1867 CE).

High throughput generation and characterization of replication-competent clade C transmitter-founder simian human immunodeficiency viruses.

Directory of Open Access Journals (Sweden)

Debashis Dutta

Full Text Available Traditional restriction endonuclease-based cloning has been routinely used to generate replication-competent simian-human immunodeficiency viruses (SHIV and simian tropic HIV (stHIV. This approach requires the existence of suitable restriction sites or the introduction of nucleotide changes to create them. Here, using an In-Fusion cloning technique that involves homologous recombination, we generated SHIVs and stHIVs based on epidemiologically linked clade C transmitted/founder HIV molecular clones from Zambia. Replacing vif from these HIV molecular clones with vif of SIVmac239 resulted in chimeric genomes used to generate infectious stHIV viruses. Likewise, exchanging HIV env genes and introducing N375 mutations to enhance macaque CD4 binding site and cloned into a SHIVAD8-EO backbone. The generated SHIVs and stHIV were infectious in TZMbl and ZB5 cells, as well as macaque PBMCs. Therefore, this method can replace traditional methods and be a valuable tool for the rapid generation and testing of molecular clones of stHIV and SHIV based on primary clinical isolates will be valuable to generate rapid novel challenge viruses for HIV vaccine/cure studies.

[Max Isserlin, Kantian orientation at Königsberg, psychotherapist with Kraepelin, founder of child psychiatry at Munich, emigrant to Britain].

Science.gov (United States)

Peters, U H

2002-01-01

This account of the life and work of Max Isserlin (1879 - 1941) wants to be a reminder of a German-Jewish fate next to Kraepelin and as a forced emigrant. Immediately after his studies at Königsberg Isserlin in 1903 came to Kraepelin at Heidelberg, later he followed him to Munich. All his life he kept a Kantian orientation and defended Kraepelin's positions out of this background. Kraepelin entrusted to him all of psychotherapy, theory and practice, which Isserlin for at least 18 years gave courses of in Kraepelin's department. His textbook of psychotherapy thus transmissions Kraepelins convictions about this topic also. During World War I Isserlin was the head of a field-hospital for brain damaged soldiers and continued working this way after the end of the war. Finally he became the founder of child psychiatry in Munich, until he was forced to leave Germany for Britain with a heavy heart.

A common founder mutation in FANCA underlies the world's highest prevalence of Fanconi anemia in Gypsy families from Spain.

Science.gov (United States)

Callén, Elsa; Casado, José A; Tischkowitz, Marc D; Bueren, Juan A; Creus, Amadeu; Marcos, Ricard; Dasí, Angeles; Estella, Jesús M; Muñoz, Arturo; Ortega, Juan J; de Winter, Johan; Joenje, Hans; Schindler, Detlev; Hanenberg, Helmut; Hodgson, Shirley V; Mathew, Christopher G; Surrallés, Jordi

2005-03-01

Fanconi anemia (FA) is a genetic disease characterized by bone marrow failure and cancer predisposition. Here we have identified Spanish Gypsies as the ethnic group with the world's highest prevalence of FA (carrier frequency of 1/64-1/70). DNA sequencing of the FANCA gene in 8 unrelated Spanish Gypsy FA families after retroviral subtyping revealed a homozygous FANCA mutation (295C>T) leading to FANCA truncation and FA pathway disruption. This mutation appeared specific for Spanish Gypsies as it is not found in other Gypsy patients with FA from Hungary, Germany, Slovakia, and Ireland. Haplotype analysis showed that Spanish Gypsy patients all share the same haplotype. Our data thus suggest that the high incidence of FA among Spanish Gypsies is due to an ancestral founder mutation in FANCA that originated in Spain less than 600 years ago. The high carrier frequency makes the Spanish Gypsies a population model to study FA heterozygote mutations in cancer.

I eto vsjo o njom... / Valentin Zvegintsev

Index Scriptorium Estoniae

Zvegintsev, Valentin

2005-01-01

Res Publica nõuniku Nikolai Stelmachi sõnul ei saa Res Publica valimisreklaami Tallinnas kuidagi plagiaadiks nimetada, tema hinnangul on Reformierakonna ja Res Publica valimisplakatid Tallinnas sisult erinevad, kuid Reformierakond võttis üle Res Publica idee lastevanemate toetamise kohta. Reformierakonna liikme Tatjana Muravjova arvamus

A novel FKRP-related muscular dystrophy founder mutation in South African Afrikaner patients with a phenotype suggestive of a dystrophinopathy

Directory of Open Access Journals (Sweden)

M M Mudau

2017-01-01

Full Text Available Background. Fukutin-related protein (FKRP muscular dystrophy is an autosomal recessive disorder caused by mutations in the FKRP gene. The condition is often misdiagnosed as a dystrophinopathy. A previously unreported mutation, c.1100T>C in exon 4 of FKRP, had been identified in homozygous form in two white South African (SA Afrikaner patients clinically diagnosed with a dystrophinopathy. Objectives. To investigate whether the c.1100T>C mutation and the common European FKRP mutation c.826C>A are present in other patients of Afrikaner origin with suspected dystrophinopathy, and whether a founder haplotype exists. Methods. The c.1100T>C mutation was initially tested for using an amplification refractory mutation system technique in 45 white SA Afrikaner patients who had tested negative using multiplex ligation probe amplification screening for exonic deletions/duplications in the dystrophin gene. Sequencing analysis was used to confirm the c.1100T>C mutation and screen for the c.826C>A mutation. Two cohorts (each numbering 100 of Afrikaans and other white controls were screened for the c.1100T>C and c.826C>A mutations, respectively. Results. Of the 45 patients, 8 patients (17.8% were homozygous for c.1100T>C, 2 (4.4% were compound heterozygotes for c.1100T>C and c.826C>A, and 1 (2.2% was heterozygous for c.1100T>C with a second unidentified mutation. The c.1100T>C mutation was found in 1/100 controls, but no heterozygotes for the c.826C>A mutation were identified. Linked marker analysis for c.1100T>C showed a common haplotype, suggesting a probable founder mutation in the SA Afrikaner population. Conclusion. FKRP mutations may be relatively common in Afrikaners, and screening should be considered in patients who have a suggestive phenotype and test negative for a dystrophinopathy. This test will be useful for offering diagnostic, carrier and prenatal testing for affected individuals and their families. As FKRP muscular dystrophy is autosomal

A enfermagem de saúde pública no Distrito Federal: a influência do relatório Goldmark (1923 A 1927 La enfermería de salud publica en el Distrito Federal: la influencia del relato goldmark (1923 hasta 1927 The public health nursing in the Distrito Federal: the influence of the goldmark report (1923 to 1927

Directory of Open Access Journals (Sweden)

Mary Ann Menezes Freire

2008-03-01

Full Text Available Estudo histórico-social, embasado na análise documental. Investiga as influências do Relatório Goldmark na organização da enfermagem de saúde pública, após o processo da Reforma Carlos Chagas, de 1923 a 1927. Objetivos: identificar as circunstâncias em que se deram as primeiras propostas para organizar a enfermagem de saúde pública durante a Reforma Carlos Chagas; analisar as implicações do Relatório Goldmark para a organização do saber e do fazer na enfermagem de saúde pública, na Capital da República, na década de 1920. Podemos citar como uma das implicações do Relatório Goldmark na organização da enfermagem de saúde pública no Distrito Federal a alteração do Standard Curriculum, adotado pela Escola de Enfermagem do Departamento Nacional de Saúde Pública, diante de uma de suas questões centrais, que procurou produzir um equilíbrio no ensino teórico-prático, o que provocou reflexos no saber e no fazer das enfermeiras de saúde pública.Estudio histórico-social basado en el análisis documental. Investiga las influencias del Relato Goldmark en la enfermería de salud publica después del proceso de la Reforma Carlos Chagas, 1923 - 1927. Objetivos: Identificar las condiciones en que ocurrieron las primeras propuestas para organizar la enfermería de salud publica en la Reforma Carlos Chagas; Analizar las implicaciones del Relato Goldmark para la organización de lo saber y de lo hacer en la enfermería de salud publica en la Capital de la Republica en la década de 1920. Podemos citar cómo una de las implicaciones del Relato Goldmark en la organización de la enfermería de salud publica en el Distrito Federal la alteración del "Standart Curriculum", adoptado por la Escuela de Enfermería del Departamento Nacional de Salud Publica, frente una de sus cuestiones centrales que intent�� producir un equilibrio en la enseñanza teórica y practica, lo que causó reflejo en lo saber y el que hacer de las

Density of founder cells affects spatial pattern formation and cooperation in Bacillus subtilis biofilms.

Science.gov (United States)

van Gestel, Jordi; Weissing, Franz J; Kuipers, Oscar P; Kovács, Akos T

2014-10-01

In nature, most bacteria live in surface-attached sedentary communities known as biofilms. Biofilms are often studied with respect to bacterial interactions. Many cells inhabiting biofilms are assumed to express 'cooperative traits', like the secretion of extracellular polysaccharides (EPS). These traits can enhance biofilm-related properties, such as stress resilience or colony expansion, while being costly to the cells that express them. In well-mixed populations cooperation is difficult to achieve, because non-cooperative individuals can reap the benefits of cooperation without having to pay the costs. The physical process of biofilm growth can, however, result in the spatial segregation of cooperative from non-cooperative individuals. This segregation can prevent non-cooperative cells from exploiting cooperative neighbors. Here we examine the interaction between spatial pattern formation and cooperation in Bacillus subtilis biofilms. We show, experimentally and by mathematical modeling, that the density of cells at the onset of biofilm growth affects pattern formation during biofilm growth. At low initial cell densities, co-cultured strains strongly segregate in space, whereas spatial segregation does not occur at high initial cell densities. As a consequence, EPS-producing cells have a competitive advantage over non-cooperative mutants when biofilms are initiated at a low density of founder cells, whereas EPS-deficient cells have an advantage at high cell densities. These results underline the importance of spatial pattern formation for competition among bacterial strains and the evolution of microbial cooperation.

Use of Dried Blood Spots to Elucidate Full-Length Transmitted/Founder HIV-1 Genomes

Directory of Open Access Journals (Sweden)

Jesus F. Salazar-Gonzalez

2016-07-01

Full Text Available Background: Identification of HIV-1 genomes responsible for establishing clinical infection in newly infected individuals is fundamental to prevention and pathogenesis research. Processing, storage, and transportation of the clinical samples required to perform these virologic assays in resource-limited settings requires challenging venipuncture and cold chain logistics. Here, we validate the use of dried-blood spots (DBS as a simple and convenient alternative to collecting and storing frozen plasma. Methods: We performed parallel nucleic acid extraction, single genome amplification (SGA, next generation sequencing (NGS, and phylogenetic analyses on plasma and DBS. Results: We demonstrated the capacity to extract viral RNA from DBS and perform SGA to infer the complete nucleotide sequence of the transmitted/founder (TF HIV-1 envelope gene and full-length genome in two acutely infected individuals. Using both SGA and NGS methodologies, we showed that sequences generated from DBS and plasma display comparable phylogenetic patterns in both acute and chronic infection. SGA was successful on samples with a range of plasma viremia, including samples as low as 1,700 copies/ml and an estimated ~50 viral copies per blood spot. Further, we demonstrated reproducible efficiency in gp160 env sequencing in DBS stored at ambient temperature for up to three weeks or at -20ºC for up to five months. Conclusions: These findings support the use of DBS as a practical and cost-effective alternative to frozen plasma for clinical trials and translational research conducted in resource-limited settings.

Análise das publicações sobre capacidades dinâmicas entre 1992 e 2012: discussões sobre a evolução conceitual e as contribuições dos autores de maior notoriedade na área.

Directory of Open Access Journals (Sweden)

André Luís Janzkovski Cardoso

2015-06-01

Full Text Available Alguns elementos constituintes da abordagem das capacidades dinâmicas aparecem em diversas publicações (Schumpeter, 1942; Penrose, 1959, Nelson & Winter, 1982, Prahalad & Hamel, 1990, mas é a partir de Teece, Pisano e Schuen (1997 que o tema capacidades dinâmicas tem despertado interesse crescente dos estudiosos. A relevância do tema tem levado pesquisadores a considerar capacidades dinâmicas como um novo e robusto paradigma no campo da estratégia, principalmente por propor respostas às lacunas deixadas pela resource-based view (RBV. O arcabouço teórico das capacidades dinâmicas sofreu alterações ao longo do tempo (Barreto, 2010 e apresenta, além de convergências, ramificações entre seus defensores, principalmente no tocante ao embasamento e às fontes teóricas utilizadas em suas diferentes concepções. O conceito de capacidade dinâmica como fonte de vantagem competitiva fez com que estudos sobre esse tema proliferassem ao longo dos últimos anos, contudo essa proliferação ocorre de maneira não homogênea e consensual, o que torna o aprofundamento do tema um desafio ainda maior. Dessa forma, considerando as principais publicações sobre o tema capacidades dinâmicas entre os anos de 1992 e 2012, esta investigação apresenta as contribuições dos principais autores para o desenvolvimento da abordagem das capacidades dinâmicas e discute sua evolução conceitual. Trata-se de um estudo bibliométrico com tratamento dos dados por meio de escala multidimensional e análise de rede. Qualitativamente, a evolução da abordagem é analisada considerando os diferentes conceitos e proposições teórico-empíricas apresentados por autores de maior notoriedade na área, em diversos estudos sobre o tema. Os resultados indicam 1. uma evolução conceitual e de proposições teórico-empíricas; 2. um aumento de citações a autores contribuintes do tema; 3. uma diversidade de fontes de publicação e multidisciplinaridade da

Comprehensive population-wide analysis of Lynch syndrome in Iceland reveals founder mutations in MSH6 and PMS2

Science.gov (United States)

Haraldsdottir, Sigurdis; Rafnar, Thorunn; Frankel, Wendy L.; Einarsdottir, Sylvia; Sigurdsson, Asgeir; Hampel, Heather; Snaebjornsson, Petur; Masson, Gisli; Weng, Daniel; Arngrimsson, Reynir; Kehr, Birte; Yilmaz, Ahmet; Haraldsson, Stefan; Sulem, Patrick; Stefansson, Tryggvi; Shields, Peter G.; Sigurdsson, Fridbjorn; Bekaii-Saab, Tanios; Moller, Pall H.; Steinarsdottir, Margret; Alexiusdottir, Kristin; Hitchins, Megan; Pritchard, Colin C.; de la Chapelle, Albert; Jonasson, Jon G.; Goldberg, Richard M.; Stefansson, Kari

2017-01-01

Lynch syndrome, caused by germline mutations in the mismatch repair genes, is associated with increased cancer risk. Here using a large whole-genome sequencing data bank, cancer registry and colorectal tumour bank we determine the prevalence of Lynch syndrome, associated cancer risks and pathogenicity of several variants in the Icelandic population. We use colorectal cancer samples from 1,182 patients diagnosed between 2000–2009. One-hundred and thirty-two (11.2%) tumours are mismatch repair deficient per immunohistochemistry. Twenty-one (1.8%) have Lynch syndrome while 106 (9.0%) have somatic hypermethylation or mutations in the mismatch repair genes. The population prevalence of Lynch syndrome is 0.442%. We discover a translocation disrupting MLH1 and three mutations in MSH6 and PMS2 that increase endometrial, colorectal, brain and ovarian cancer risk. We find thirteen mismatch repair variants of uncertain significance that are not associated with cancer risk. We find that founder mutations in MSH6 and PMS2 prevail in Iceland unlike most other populations. PMID:28466842

Academician L. V. Pisarzhevsky is the founder of chemical science and education in Dnipropetrovsk university

Directory of Open Access Journals (Sweden)

Valerij S. Kovalenko

2014-12-01

Full Text Available The article is devoted to the 140 anniversary of birth of the academician Lev Vladimirovich Pisarzhevsky, who was a distinguished chemical scientist, founder of the important area of chemical science – electronic chemistry. The article dwells upon the basic stages of the scientist’s life and creative art. The major results of scientific and educational activity during Dnipropetrovsk period of his life are reported. His role in the foundation of dnipropetrovsk scientific school of physical chemistry, as well as in its establishment, is shown. The pioneering role of the academician L. V. Pisarzhevsky in the formation of the theory of redox reactions as processes of returning and joining of electrons, which is generally accepted nowadays, as well as in the creation of backgrounds of modern electronic theories of catalysis, has been shown. L. V. Pisarzhevsky is characterized as a wonderful lecturer and teacher who expounded chemical material from the point of view of electronic conception and laid the foundation for the reformation of chemistry. The role of the academician L. V. Pisarzhevsky in the foundation of Dnipropetrovsk University and its chemical department, as well as in the organization of educational process in this establishment, is exposed using archive materials, which are kept in the funds of the State Archive of the Dnipropetrovsk region and of the historical museum of Oles Honchar Dnipropetrovsk National University.

Alfred Russel Wallace (1823-1913): the forgotten co-founder of the Neo-Darwinian theory of biological evolution.

Science.gov (United States)

Kutschera, Ulrich; Hossfeld, Uwe

2013-12-01

The British naturalist Alfred Russel Wallace (1823-1913), who had to leave school aged 14 and never attended university, did extensive fieldwork, first in the Amazon River basin (1848-1852) and then in Southeast Asia (1854-1862). Based on this experience, and after reading the corresponding scientific literature, Wallace postulated that species were not created, but are modified descendants of pre-existing varieties (Sarawak Law paper, 1855). Evolution is brought about by a struggle for existence via natural selection, which results in the adaptation of those individuals in variable populations who survive and reproduce (Ternate essay, 1858). In his monograph Darwinism (1889), and in subsequent publications, Wallace extended the contents of Darwin's Origin of Species (1859) into the Neo-Darwinian theory of biological evolution, with reference to the work of August Weismann (1834-1914). Wallace also became the (co)-founder of biogeography, biodiversity research, astrobiology and evolutionary anthropology. Moreover, he envisioned what was later called the anthropocene (i.e., the age of human environmental destructiveness). However, since Wallace believed in atheistic spiritualism and mixed up scientific facts and supernatural speculations in some of his writings, he remains a controversial figure in the history of biology.

The end of capitalism and its future: Hegel as founder of the concept of a welfare state

Directory of Open Access Journals (Sweden)

Vieweg Klaus

2017-01-01

Full Text Available A key part of Hegel’s practical philosophy is his theory of civil society and the idea of a rational regulation of the market. This is the foundation of Hegel’s theory of a social state. The copyright on the notion of a modern society of freedom and a rational, social state belongs to Hegel. Hegel proves himself to be the thinker who until now has provided the most convincing foundation for freedom in modernity. The theoretical foundation and at the same time bone of contention of Hegel’s political thought is to be found in his concept of ethical life (Sittlichkeit, in particular in his theory of civil society. The current shipwreck of deregulated capitalism does not mean the foundering of our journey towards a free society. Nevertheless the deficiencies and unsustainability of both traditional models - socialist collective ownership and market fundamentalism - exhibit two contradictory claims to a share of the wealth of nations. To take up Hegel’s project is, in essence, to aim at a new conception of an environmentally and socially sustainable and just society, and a corresponding world order. It is to further Hegel’s philosophy of freedom.

Analisis del contenido curricular de los Documentos Normativos del Programa de Ciencias en el area de biologia para la escuela superior del sistema de educacion publica de Puerto Rico: 1993-2012

Science.gov (United States)

Davila Montanez, Melissa

Esta investigacion de naturaleza cualitativa se ocupo de realizar un analisis de contenido documental de los Documentos Normativos del Programa de Ciencias en el area de biologia de la escuela superior del sistema de educacion publica de Puerto Rico del periodo 1993-2012. Los documentos analizados fueron: Guia Curricular, 1995; Marco Curricular, 2003; Estandares de Excelencia, 1996, 2000 y Estandares de Contenido y Expectativas de Grado, 2007. Se indago si hubo cambios en significados en los Componentes Estructurales: Naturaleza de la ciencia, Paradigmas para la ensenanza de la ciencia, Funcion del curriculo formal, Mision de la ensenanza de la ciencia; Contenidos, destrezas y competencias, Estrategias de ensenanza y Evaluacion/Assessment del aprendizaje. El analisis sugiere que no hubo cambios sustanciales en los significados de los Componentes Estructurales. Los documentos estudiados muestran mayormente caracteristicas similares, aunque los documentos mas recientes eran mas descriptivos, explicativos y especificos.

A publicação de periódicos científicos digitais

Directory of Open Access Journals (Sweden)

Rosângela Schwarz Rodrigues

2011-05-01

Full Text Available http://dx.doi.org/10.5007/1518-2924.2011v16n31pi Os periódicos científicos aumentam de importância na medida em que Ciência e Tecnologia são entendidas como essenciais para o bem estar da população e o desenvolvimento sustentável dos países. Como responsáveis pela certificação e divulgação dos resultados das pesquisas em todas as áreas, os periódicos são os canais de comunicação prioritários da ciência. Em função da relevância crescente da publicação científica em todas as áreas do conhecimento, os periódicos são pressionados cada vez mais a elevar seus padrões de qualidade, com o objetivo de atrair mais e melhores artigos, o que implica em maior número de leitores e citações. As instituições de fomento e avaliação da ciência consideram a publicação como elemento final do ciclo da pesquisa, e indicador quantitativo e qualitativo para a construção de confiabilidade e prestígio para os indivíduos, grupos e instituições que formam a rede. A Ciência da Informação é área que tem no estudo da Comunicação Científica uma de suas principais vertentes e esta condição exige que tenhamos excelentes e inovadores periódicos. A Encontros Bibli: revista de biblioteconomia e ciência da informação é pioneira, sendo a primeira revista exclusivamente digital da Ciência da Informação no Brasil. Em 1996, no dia 09 de maio, a revista Encontros Bibli, por iniciativa do então Departamento de Biblioteconomia e Documentação, atual Departamento de Ciência da Informação da Universidade Federal de Santa Catarina (UFSC, ingressava na Web, a partir de seu primeiro número, utilizando a ferramenta HTML e mais tarde agregando outros recursos de edição, como a edição final dos textos em PDF. Desde então, tem se mantido neste ambiente, com periodicidade semestral e edições especiais. No ano 2003, a Encontros Bibli foi incluída na Rede de Revistas Cientificas da América Latina, Caribe, Espanha e

A publicação de periódicos científicos digitais

Directory of Open Access Journals (Sweden)

Rosângela Schwarz Rodrigues

2011-05-01

Full Text Available Os periódicos científicos aumentam de importância na medida em que Ciência e Tecnologia são entendidas como essenciais para o bem estar da população e o desenvolvimento sustentável dos países. Como responsáveis pela certificação e divulgação dos resultados das pesquisas em todas as áreas, os periódicos são os canais de comunicação prioritários da ciência.Em função da relevância crescente da publicação científica em todas as áreas do conhecimento, os periódicos são pressionados cada vez mais a elevar seus padrões de qualidade, com o objetivo de atrair mais e melhores artigos, o que implica em maior número de leitores e citações. As instituições de fomento e avaliação da ciência consideram a publicação como elemento final do ciclo da pesquisa, e indicador quantitativo e qualitativo para a construção de confiabilidade e prestígio para os indivíduos, grupos e instituições que formam a rede.A Ciência da Informação é área que tem no estudo da Comunicação Científica uma de suas principais vertentes e esta condição exige que tenhamos excelentes e inovadores periódicos. A Encontros Bibli: revista de biblioteconomia e ciência da informação é pioneira, sendo a primeira revista exclusivamente digital da Ciência da Informação no Brasil.Em 1996, no dia 09 de maio, a revista Encontros Bibli, por iniciativa do então Departamento de Biblioteconomia e Documentação, atual Departamento de Ciência da Informação da Universidade Federal de Santa Catarina (UFSC, ingressava na Web, a partir de seu primeiro número, utilizando a ferramenta HTML e mais tarde agregando outros recursos de edição, como a edição final dos textos em PDF. Desde então, tem se mantido neste ambiente, com periodicidade semestral e edições especiais.No ano 2003, a Encontros Bibli foi incluída na Rede de Revistas Cientificas da América Latina, Caribe, Espanha e Portugal (REDALYC e pelo Sistema Regional de Informaci

Caracterización de las publicaciones periódicas de la enfermería en Colombia visibles en Internet Caracterização das publicações periódicas da enfermagem na Colómbia visíveis na Internet Characterization of periodical publications on nursing in Colombia, visible in the Internet

Directory of Open Access Journals (Sweden)

Lorena Mesa Melgarejo

2011-07-01

Full Text Available La publicación de la producción científica es determinante. Lipara el crecimiento disciplinar. Las publicaciones periódicas son el mecanismo más efectivo y válido para divulgar textos de carácter científico. Este estudio buscó caracterizar y describir las publicaciones periódicas de la enfermería colombiana existentes y contextualizar de una manera más aproximada las posibilidades de divulgación de la producción científica de los profesionales de enfermería en Colombia. Método: estudio descriptivo. Se realizaron búsquedas en línea en diferentes bases de datos para hallar las revistas y publicaciones editadas por organizaciones o instituciones de enfermería colombianas que se hacen visibles a través de internet. Resultados: las búsquedas en la red arrojaron un total de 18 publicaciones, de las cuales 12 (67% corresponden a ediciones de facultades y escuelas de enfermería de universidades nacionales públicas y privadas; 3 (17% son boletines informativos; 2 (11% son revistas de organizaciones gremiales y 1 (5% es una publicación editada por un hospital universitario. Discusión: la búsqueda de las revistas que hicieron parte de este estudio fue una travesía compleja; la visibilidad de muchas publicaciones, incluso en buscadores genéricos, es baja, casi nula, situación que estaría de acuerdo con la llamada "cultura del enclaustramiento", lo que implica que, a pesar de la gran cantidad de artículos de interés y de calidad que estas revistas publican, sus aportes teórico-metodológicos a la disciplina de enfermería no tengan mayor impacto.Apublicação da produção científica é determinante para o rescimento disciplinar. As publicações periódicas são os mecanismos mais efetivos e válidos para divulgar textos de natureza científica. Este estudo busca caracterizar e descrever as publicações periódicas da enfermagem colombiana existentes e contextualizar de forma mais apropriada as possibilidades de divulga

Founder effects and the evolution of asymmetrical sexual isolation in a rapidly-speciating clade

Directory of Open Access Journals (Sweden)

Kevin P. OH, Gina L. CONTE, Kerry L. SHAW

2013-04-01

Full Text Available Sexual isolation resulting from differences in mate choice behaviors is a hallmark of rapidly-speciating lineages. When present, asymmetrical sexual isolation may provide insights into the mechanisms responsible for the evolutionary change in mate signaling traits. In particular, Kaneshiro’s hypothesis suggests that divergence in sexual characters between populations may arise in allopatry when ‘derived’ founding populations are subject to severe population bottlenecks, accompanied by a relaxation of sexual selection relative to ‘ancestral’ source populations. In the present study, we tested predictions of asymmetrical sexual isolation between two allopatric species of Hawaiian Laupala crickets, representing ‘ancestral’ (L. makaio and ‘derived’ (L. nigra taxa. While crickets in this genus are notable for rapid divergence of male courtship songs, these species share similar song types, thus suggesting that patterns of sexual isolation are likely due to other mating cues. Analysis of behavioral responses in conspecific and heterospecific ‘no-choice’ mating trials revealed pronounced asymmetrical isolation in the direction predicted by Kaneshiro’s hypothesis, wherein we observed a significant reduction in mating success for crosses involving ‘derived’ males paired with ‘ancestral’ females, compared to the reciprocal heterospecific and both conspecific pairings. Further dissection of courtship behaviors suggested this difference did not reflect male mate choice, but rather, marked reduced spermatophore acceptance rates by ‘ancestral’ females paired with ‘derived’ males. The results are discussed with respect to founder effect models of speciation and the potential role of chemosensory signals in mate choice in these species [Current Zoology 59 (2: 230-238, 2013].

Ground states of molecules. XLIX. MINDO/3 study of the retro-diels-alder reaction of cyclohexene

International Nuclear Information System (INIS)

Dewar, M.J.S.; Olivella, S.; Rzepa, H.S.

1978-01-01

The retro-Diels-Alder reaction of cyclohexene to form ethylene and butadiene has been studied, using MINDO/3. The transition state is predicted to be very unsymmetric, corresponding to weakening of one of the two breaking CC bonds. The calculated entropy of activation agrees well with experiment and the calculated secondary isotope effects for 4,4-dideuteriocyclohexene and 4,4,5,5-tetradeuteriocyclohexene are similar to those measured for an analogous reaction by Taagepera and Thornton. Discrepancies between the conclusions reached here and those from recent ab-initio calculations are discussed. 4 tables, 3 figures, 53 references

Who were the male founders of rural Brazilian Afro-derived communities? A proposal based on three populations.

Science.gov (United States)

Ribeiro, Guilherme Galvarros Bueno Lobo; Abe-Sandes, Kiyoko; Barcelos, Rejane da Silva Sena; Klautau-Guimarães, Maria de Nazaré; Junior, Wilson Araujo da Silva; Oliveira, Silviene Fabiana de

2011-03-01

Brazilian Quilombos are Afro-derived communities founded mainly by fugitive slaves between the 16(th) and 19(th) centuries; they can be recognized today by ancestral and cultural characteristics. Each of these remnant communities, however, has its own particular history, which includes the migration of non-African derived people. The present work presents a proposal for the origin of the male founder in Brazilian quilombos based on Y-haplogroup distribution. Y haplogroups, based on 16 binary markers (92R7, SRY2627, SRY4064, SRY10831.1 and .2, M2, M3, M09, M34, M60, M89, M213, M216, P2, P3 and YAP), were analysed for 98 DNA samples from genetically unrelated men from three rural Brazilian Afro-derived communities-Mocambo, Rio das Rãs and Kalunga-in order to estimate male geographic origin. Data indicated significant differences among these communities. A high frequency of non-African haplogroups was observed in all communities. This observation suggested an admixture process that has occurred over generations and directional mating between European males and African female slaves that must have occurred on farms before the slaves escaped. This means that the admixture occurred before the slaves escaped and the foundation of the quilombo.

Generation and Characterization of HIV-1 Transmitted and Founder Virus Consensus Sequence from Intravenous Drug Users in Xinjiang, China.

Science.gov (United States)

Li, Fan; Ma, Liying; Feng, Yi; Hu, Jing; Ni, Na; Ruan, Yuhua; Shao, Yiming

2017-06-01

HIV-1 transmission in intravenous drug users (IDUs) has been characterized by high genetic multiplicity and suggests a greater challenge for HIV-1 infection blocking. We investigated a total of 749 sequences of full-length gp160 gene obtained by single genome sequencing (SGS) from 22 HIV-1 early infected IDUs in Xinjiang province, northwest China, and generated a transmitted and founder virus (T/F virus) consensus sequence (IDU.CON). The T/F virus was classified as subtype CRF07_BC and predicted to be CCR5-tropic virus. The variable region (V1, V2, and V4 loop) of IDU.CON showed length variation compared with the heterosexual T/F virus consensus sequence (HSX.CON) and homosexual T/F virus consensus sequence (MSM.CON). A total of 26 N-linked glycosylation sites were discovered in the IDU.CON sequence, which is less than that of MSM.CON and HSX.CON. Characterization of T/F virus from IDUs highlights the genetic make-up and complexity of virus near the moment of transmission or in early infection preceding systemic dissemination and is important toward the development of an effective HIV-1 preventive methods, including vaccines.

Mapping of Chagas disease research: analysis of publications in the period between 1940 and 2009 Mapeamento de pesquisa da doença de Chagas: análise da produção de publicações no período entre 1940 e 2009

Directory of Open Access Journals (Sweden)

José Manuel Ramos

2011-12-01

Full Text Available INTRODUCTION: Publications are often used as a measure of success in research work. Chagas disease occurs in Central and Southern America. However, during the past years, the disease has been occurring outside Latin America due to migration from endemic zones. This article describes a bibliometric review of the literature on Chagas disease research indexed in PubMed during a 70-year period. METHODS: Medline was used via the PubMed online service of the U.S. National Library of Medicine from 1940 to 2009. The search strategy was: Chagas disease [MeSH] OR Trypanosoma cruzi [MeSH]. RESULTS: A total of 13,989 references were retrieved. The number of publications increased steadily over time from 1,361 (1940-1969 to 5,430 (2000-2009 (coefficient of determination for linear fit, R²=0.910. Eight journals contained 25% of the Chagas disease literature. Of the publications, 64.2% came from endemic countries. Brazil was the predominant country (37%, followed by the United States (17.6% and Argentina (14%. The ranking in production changed when the number of publications was normalized by estimated cases of Chagas disease (Panama and Uruguay, population (Argentina and Uruguay, and gross domestic product (Bolivia and Brazil. CONCLUSIONS: Several Latin American countries, where the prevalence of T. cruzi infection was not very high, were the main producers of the Chagas disease literature, after adjusting for economic and population indexes. The countries with more estimated cases of Chagas disease produced less research on Chagas disease than some developed countries.INTRODUÇÃO: Publicações são frequentemente utilizadas como uma medida de sucesso do trabalho de pesquisa. A doença de Chagas (DCh ocorre na América Central e do Sul. Porém, durante os últimos anos, a doença tem ocorrido fora da América Latina, devido à migração das zonas endêmicas. Este artigo descreve uma análise bibliométrica da literatura sobre as pesquisas da doença de

Tallinna võim on libastumine?

Index Scriptorium Estoniae

2005-01-01

Elmar Sepp ja Tõnis Palts vastavad küsimusele, mis puudutab Taavi Veskimäe väidet, et Res Publica koostöö Tallinnas on Res Publica suurima poliitilise libastumise tagajärg. Elmar Sepp ei välista sügisestel valimistel Keskerakonna ja Res Publica koostöö jätkumist Tallinnas, tema sõnul ei ole Keskerakond mitte totalitaarne, vaid Eesti üks demokraatlikumaid erakondi. Vt. samas: Katkend Taavi Veskimäe kõnest Res Publica üldkogul

Mineração de texto aplicada às publicações científicas sobre gestão do conhecimento no período de 2003 a 2012

Directory of Open Access Journals (Sweden)

Cicero Aparecido Bezerra

Full Text Available Desde sua apresentação, em meados da década de 1980, o tema 'Gestão do Conhecimento' (GC tem sido abordado sob os mais diversos aspectos. Neste sentido, uma vez observado o aumento da quantidade de trabalhos publicados em bases acadêmicas, nos últimos 10 anos, os objetivos da presente pesquisa são (1 encontrar os termos mais empregados nestes trabalhos e as (2 diferenças entre os termos encontrados em publicações brasileiras e estrangeiras. Para isto, empregou-se a técnica de mineração de textos. Os resultados mostram que temas envolvendo práticas, processos, sistemas de GC e tecnologias de informação são recorrentemente encontrados tanto em resumos de artigos nacionais como internacionais. Por outro lado, de maneira geral, os artigos nacionais se distinguem pelo fato de apresentarem termos mais associados a aspectos abstratos da GC (modelos, conhecimento tácito e organizacional, enquanto que os internacionais caracterizam-se por termos mais pragmáticos (efetividade, implementação, relacionamentos e desenvolvimento.

An USH2A founder mutation is the major cause of Usher syndrome type 2 in Canadians of French origin and confirms common roots of Quebecois and Acadians

Science.gov (United States)

Ebermann, Inga; Koenekoop, Robert K; Lopez, Irma; Bou-Khzam, Lara; Pigeon, Renée; Bolz, Hanno J

2009-01-01

Congenital hearing loss affects approximately one child in 1000. About 10% of the deaf population have Usher syndrome (USH). In USH, hearing loss is complicated by retinal degeneration with onset in the first (USH1) or second (USH2) decade. In most populations, diagnostic testing is hampered by a multitude of mutations in nine genes. We have recently shown that in French Canadians from Quebec, USH1 largely results from a single USH1C founder mutation, c.216G>A (‘Acadian allele'). The genetic basis of USH2 in Canadians of French descent, however, has remained elusive. Here, we have investigated nine USH2 families from Quebec and New Brunswick (the former Acadia) by haplotype analyses of the USH2A locus and sequencing of the three known USH2 genes. Seven USH2A mutations were identified in eight patients. One of them, c.4338_4339delCT, accounts for 10 out of 18 disease alleles (55.6%). This mutation has previously been reported in an Acadian USH2 family, and it was found in homozygous state in the three Acadians of our sample. As in the case of c.216G>A (USH1C), a common haplotype is associated with c.4338_4339delCT. With a limited number of molecular tests, it will now be possible in these populations to estimate whether children with congenital hearing impairment of different degrees will develop retinal disease – with important clinical and therapeutic implications. USH2 is the second example that reveals a significant genetic overlap between Quebecois and Acadians: in contrast to current understanding, other genetic disorders present in both populations are likely based on common founder mutations as well. PMID:18665195

An USH2A founder mutation is the major cause of Usher syndrome type 2 in Canadians of French origin and confirms common roots of Quebecois and Acadians.

Science.gov (United States)

Ebermann, Inga; Koenekoop, Robert K; Lopez, Irma; Bou-Khzam, Lara; Pigeon, Renée; Bolz, Hanno J

2009-01-01

Congenital hearing loss affects approximately one child in 1000. About 10% of the deaf population have Usher syndrome (USH). In USH, hearing loss is complicated by retinal degeneration with onset in the first (USH1) or second (USH2) decade. In most populations, diagnostic testing is hampered by a multitude of mutations in nine genes. We have recently shown that in French Canadians from Quebec, USH1 largely results from a single USH1C founder mutation, c.216G>A ('Acadian allele'). The genetic basis of USH2 in Canadians of French descent, however, has remained elusive. Here, we have investigated nine USH2 families from Quebec and New Brunswick (the former Acadia) by haplotype analyses of the USH2A locus and sequencing of the three known USH2 genes. Seven USH2A mutations were identified in eight patients. One of them, c.4338_4339delCT, accounts for 10 out of 18 disease alleles (55.6%). This mutation has previously been reported in an Acadian USH2 family, and it was found in homozygous state in the three Acadians of our sample. As in the case of c.216G>A (USH1C), a common haplotype is associated with c.4338_4339delCT. With a limited number of molecular tests, it will now be possible in these populations to estimate whether children with congenital hearing impairment of different degrees will develop retinal disease - with important clinical and therapeutic implications. USH2 is the second example that reveals a significant genetic overlap between Quebecois and Acadians: in contrast to current understanding, other genetic disorders present in both populations are likely based on common founder mutations as well.

25 June 2010 - Founder Chairman of the Japanese Science and Technology in Society Forum K. Omi signing the guest book with Head of International Relations F. Pauss, Adviser J. Ellis and Director-General R. Heuer; in the ATLAS visitor centre with Former Collaboration Spokesperson P. Jenni.

CERN Multimedia

2010-01-01

25 June 2010 - Founder Chairman of the Japanese Science and Technology in Society Forum K. Omi signing the guest book with Head of International Relations F. Pauss, Adviser J. Ellis and Director-General R. Heuer; in the ATLAS visitor centre with Former Collaboration Spokesperson P. Jenni.

Erakondade suuruse ennustamine : Skytte auhinnaloeng / Rein Taagepera ; autori tõlge

Index Scriptorium Estoniae

Taagepera, Rein, 1933-

2009-01-01

27. septembril 2008 Skytte auhinna vastuvõtu kõne ning Uppsala ülikooli peahoones peetud auhinnaloeng, kus autor selgitab, milles seisneb süvaanalüüs valimissüsteemide osa kohta esindusdemokraatias

The History of the Foundation of the Iranian National Blood Transfusion Service in 1974 and the Biography of its Founder; Professor Fereydoun Ala.

Science.gov (United States)

Azizi, Mohammad Hossein; Nayernouri, Touraj; Bahadori, Moslem

2015-06-01

The history of early attempts of blood transfusion in Iran traces back to the 1940s; however, around three decades later in 1974, the Iranian National Blood Transfusion Service (Sazeman-e Melli-e Enteqal-e Khun-e Iran) was founded by the outstanding hematologist, Professor Fereydoun Ala. The main goals of this centralized organization were to collect blood from healthy voluntary donors, to screen the donated blood and to provide various safe blood products based on scientific and ethical standards. In due course, a new era of blood transfusion service in Iran had begun to such a degree that after more than four decades of its activity, it is now considered the best-developed blood service in the eastern Mediterranean region. Here, a brief historical account of the early blood transfusion efforts and the establishment of the modern Iranian National Blood Transfusion Service in Iran is discussed in addition to the life and career of its founder and first director, Professor Fereydoun Ala.

Erakonnaga või valimisliiduga? / Toivo Kratt

Index Scriptorium Estoniae

Kratt, Toivo

2005-01-01

Res Publica Viimsi osakonna esimehe sõnul ei takista erakonna kesised reitingunumbrid Viimsi vallas koostamast tugevat Res Publica nimekirja. Ta on veendunud erakonna toetuse suurenemises nii Harjumaal kui ka kogu Eestis ning peab õigeks, kui Res Publica liikmed kandideerivad erakonna nimekirjades ka siis, kui valimisliit võiks tuua rohkem hääli

Entre a viagem, a escrita e a publicação do relato, um mar de interesses. Argentina, Chile e Nova Zelândia comparados pelo britânico Robert FitzRoy na década de 1830

Directory of Open Access Journals (Sweden)

Gabriel Passetti

2013-06-01

Full Text Available Este artigo tem por objetivo discutir as relações entre a viagem, a escrita, a publicação de um relato e os interesses pessoais e a conjuntura social e política no momento de sua redação. A discussão recai sobre as escolhas na seleção de temas e formas de descrever locais, a partir de objetivos pessoais, econômicos ou políticos. São analisadas as imagens da América do Sul e da Oceania presentes no livro Narrative of the surveying voyages of HMS Beagle, produzido pelo comandante da Marinha Britânica Robert FitzRoy, entre os anos de 1836 e 1839, no contexto de intensas discussões e projetos para a expansão do império britânico.

Ética na publicação de pesquisas sobre leishmaniose visceral humana em periódicos nacionais Ética en la publicación de investigaciones sobre leishmaniasis visceral humana en periódicos brasileños Ethics in the publication of studies on human visceral leishmaniasis in Brazilian periodicals

OpenAIRE

Guilherme Malafaia; Aline Sueli de Lima Rodrigues; André Talvani

2011-01-01

OBJETIVO: Analisar os aspectos éticos dos artigos nacionais sobre leishmaniose visceral humana publicados após a Resolução CNS 196/1996 e analisar a política de periódicos brasileiros sobre ética em pesquisa. MÉTODOS: Estudo exploratório de natureza bibliográfica e documental. A seleção das publicações sobre pesquisas envolvendo seres humanos foi realizada na base SciELO Brasil a partir de 1996. Foram analisadas lacunas relacionadas às políticas editoriais dos periódicos médicos a partir de i...

Preparando o despertar de Lilith: a enfermagem no feminino retratada pelas publicações da REBEn durante as décadas de oitenta e noventa do século XX

Directory of Open Access Journals (Sweden)

Lucia Helena Rodrigues Costa

2002-02-01

Full Text Available Este estudo apresenta um levantamento das publicações da Revista Brasileira de Enfermagem/REBEn durante as décadas de 80 e 90 do século XX relativas especificamente 'as condições da mulher e/ou mulher/enfermeira. Inicialmente pensei em levantar apenas os artigos que apresentassem alguma referência à gênero, mas percebi que desde o início dos anos oitenta alguns artigos já apontavam na direção da problemática que envolve as mulheres socialmente e as implicações dessa problemática para o exercício da enfermagem, sem no entanto utilizar especificamente a categoria gênero. Assim, optei por uma avaliação dos resumos e conteúdos dos artigos no sentido de detectar todos aqueles pertinentes à essa área de interesse. Foram selecionados 11 artigos e dois editoriais temáticos que inserem a REBEn ( embora num primeiro momento pareça uma inserção tímida efetivamente como revista contextualizada com os momentos decisivos do movimento das mulheres a nível mundial.

Juhan Parts : näoga tuleviku poole / Juhan Parts ; interv. Märt Kivine

Index Scriptorium Estoniae

Parts, Juhan, 1966-

2005-01-01

Res Publica esimehe kohalt lahkuv Juhan Parts ütleb, et erakond on jäänud endaks - ausaks. Res Publica praeguse seisu üks põhjusi on tema arvates see, et erakond pole võtnud omaks vana poliitika lähenemisviise, ükski olemasolev erakond ei taha näha Res Publicat Eesti poliitikas. Lisa: Res Publica valib uue juhi

Novel NTRK1 mutations cause hereditary sensory and autonomic neuropathy type IV: demonstration of a founder mutation in the Turkish population.

Science.gov (United States)

Tüysüz, Beyhan; Bayrakli, Fatih; DiLuna, Michael L; Bilguvar, Kaya; Bayri, Yasar; Yalcinkaya, Cengiz; Bursali, Aysegul; Ozdamar, Elif; Korkmaz, Baris; Mason, Christopher E; Ozturk, Ali K; Lifton, Richard P; State, Matthew W; Gunel, Murat

2008-05-01

Hereditary sensory and autonomic neuropathy type IV (HSAN IV), or congenital insensitivity to pain with anhidrosis, is an autosomal recessive disorder characterized by insensitivity to noxious stimuli, anhidrosis from deinnervated sweat glands, and delayed mental and motor development. Mutations in the neurotrophic tyrosine kinase receptor type 1 (NTRK1), a receptor in the neurotrophin signaling pathway phosphorylated in response to nerve growth factor, are associated with this disorder. We identified six families from Northern Central Turkey with HSAN IV. We screened the NTRK1 gene for mutations in these families. Microsatellite and single nucleotide polymorphism (SNP) markers on the Affymetrix 250K chip platform were used to determine the haplotypes for three families harboring the same mutation. Screening for mutations in the NTRK1 gene demonstrated one novel frameshift mutation, two novel nonsense mutations, and three unrelated kindreds with the same splice-site mutation. Genotyping of the three families with the identical splice-site mutation revealed that they share the same haplotype. This report broadens the spectrum of mutations in NTRK1 that cause HSAN IV and demonstrates a founder mutation in the Turkish population.

Mutation screening of the HGD gene identifies a novel alkaptonuria mutation with significant founder effect and high prevalence.

Science.gov (United States)

Sakthivel, Srinivasan; Zatkova, Andrea; Nemethova, Martina; Surovy, Milan; Kadasi, Ludevit; Saravanan, Madurai P

2014-05-01

Alkaptonuria (AKU) is an autosomal recessive disorder; caused by the mutations in the homogentisate 1, 2-dioxygenase (HGD) gene located on Chromosome 3q13.33. AKU is a rare disorder with an incidence of 1: 250,000 to 1: 1,000,000, but Slovakia and the Dominican Republic have a relatively higher incidence of 1: 19,000. Our study focused on studying the frequency of AKU and identification of HGD gene mutations in nomads. HGD gene sequencing was used to identify the mutations in alkaptonurics. For the past four years, from subjects suspected to be clinically affected, we found 16 positive cases among a randomly selected cohort of 41 Indian nomads (Narikuravar) settled in the specific area of Tamil Nadu, India. HGD gene mutation analysis showed that 11 of these patients carry the same homozygous splicing mutation c.87 + 1G > A; in five cases, this mutation was found to be heterozygous, while the second AKU-causing mutation was not identified in these patients. This result indicates that the founder effect and high degree of consanguineous marriages have contributed to AKU among nomads. Eleven positive samples were homozygous for a novel mutation c.87 + 1G > A, that abolishes an intron 2 donor splice site and most likely causes skipping of exon 2. The prevalence of AKU observed earlier seems to be highly increased in people of nomadic origin. © 2014 John Wiley & Sons Ltd/University College London.

A homozygous founder missense variant in arylsulfatase G abolishes its enzymatic activity causing atypical Usher syndrome in humans.

Science.gov (United States)

Khateb, Samer; Kowalewski, Björn; Bedoni, Nicola; Damme, Markus; Pollack, Netta; Saada, Ann; Obolensky, Alexey; Ben-Yosef, Tamar; Gross, Menachem; Dierks, Thomas; Banin, Eyal; Rivolta, Carlo; Sharon, Dror

2018-01-04

PurposeWe aimed to identify the cause of disease in patients suffering from a distinctive, atypical form of Usher syndrome.MethodsWhole-exome and genome sequencing were performed in five patients from three families of Yemenite Jewish origin, suffering from distinctive retinal degeneration phenotype and sensorineural hearing loss. Functional analysis of the wild-type and mutant proteins was performed in human fibrosarcoma cells.ResultsWe identified a homozygous founder missense variant, c.133G>T (p.D45Y) in arylsulfatase G (ARSG). All patients shared a distinctive retinal phenotype with ring-shaped atrophy along the arcades engirdling the fovea, resulting in ring scotoma. In addition, patients developed moderate to severe sensorineural hearing loss. Both vision and hearing loss appeared around the age of 40 years. The identified variant affected a fully conserved amino acid that is part of the catalytic site of the enzyme. Functional analysis of the wild-type and mutant proteins showed no basal activity of p.D45Y.ConclusionHomozygosity for ARSG-p.D45Y in humans leads to protein dysfunction, causing an atypical combination of late-onset Usher syndrome. Although there is no evidence for generalized clinical manifestations of lysosomal storage diseases in this set of patients, we cannot rule out the possibility that mild and late-onset symptoms may appear.GENETICS in MEDICINE advance online publication, 4 January 2018; doi:10.1038/gim.2017.227.

Fifty-five years (1955-2010) of the Coagulation Section at Laboratory of Hematology, Sestre milosrdnice University Hospital, and its founder, hematologist Ljubomir Popović.

Science.gov (United States)

Stancić, Vladimir; Stancić, Nevenka; Vucelić, Vesna; Lang, Nada; Grbac, Ljiljana

2011-09-01

The Coagulation Section at Laboratory of Hematology, Sestre milosrdnice University Hospital, Zagreb, was founded in 1955 by Ljubomir Popović, hematologist and assistant at School of Medicine, University of Zagreb, in cooperation with hard-working laboratory technicians. Apart from papers on hematologic neoplasms, plasmacytoma and lymphoma, Ljubomir Popović published a number of papers in the field of anticoagulant therapy with heparin and oral anticoagulants, some of which are also in use today. After Ljubomir Popović left the Hospital in 1964, the Laboratory was run by Professor Nedjeljko Milić, head of the newly founded Division of Hematology. In 1968, the management of the Laboratory of Hematology was taken over by Biserka Raić, MS, medical biochemist, until her retirement in 2007. Great development in morphological and cytometric studies of blood and blood cells has been paralleled by continuous progress and almost dominating activities in the diagnosis of hemostasis disorders. In the 1970s, Marko Koprcina, hematologist, and Biserka Raić introduced the then latest tests in practice at all Hospital departments. In that golden age of the Coagulation Section, M. Koprcina, B. Raić and their associates transferred their knowledge to all colleagues in the Hospital. Through that collaboration, high standards in the diagnosis of hemostasis disorders were achieved, from which the currently high level of clinical knowledge about coagulation disorders and their treatment has derived, making Sestre milosrdnice University Hospital one of the leading hospitals in this field in the country. By describing development of the Coagulation Section and the life of its founder Ljubomir Popović, the authors tried to provide an answer to the following question: can today's clinicians still have a deciding role in laboratory development, considering that assessments of different phenomena are always initiated by an interested clinician who is trying to interpret and understand

Koalitsionnoje rasputje / Josef Kats

Index Scriptorium Estoniae

Kats, Josef, 1977-

2005-01-01

Reformierakond ja Res Publica hakkasid otsima võimalikke koalitsioonipartnereid. Res Publica peasekretäri Ott Lumi arvates peaksid uue valitsuse moodustama justiitsministrile umbusaldust avaldanud erakonnad

TP53 mutations in ovarian carcinomas from sporadic cases and carriers of two distinct BRCA1 founder mutations; relation to age at diagnosis and survival

International Nuclear Information System (INIS)

Kringen, Pedro; Wang, Yun; Dumeaux, Vanessa; Kristensen, Gunnar; Borresen-Dale, Anne-Lise; Dorum, Anne

2005-01-01

Ovarian carcinomas from 30 BRCA1 germ-line carriers of two distinct high penetrant founder mutations, 20 carrying the 1675delA and 10 the 1135insA, and 100 sporadic cases were characterized for somatic mutations in the TP53 gene. We analyzed differences in relation to BRCA1 germline status, TP53 status, survival and age at diagnosis, as previous studies have not been conclusive. DNA was extracted from paraffin embedded formalin fixed tissues for the familial cases, and from fresh frozen specimen from the sporadic cases. All cases were treated at our hospital according to protocol. Mutation analyses of exon 2 – 11 were performed using TTGE, followed by sequencing. Survival rates for BRCA1-familial cases with TP53 mutations were not significantly lower than for familial cases without TP53 mutations (p = 0.25, RR = 1.64, 95% CI [0.71–3.78]). Median age at diagnosis for sporadic (59 years) and familial (49 years) cases differed significantly (p < 0.001) with or without TP53 mutations. Age at diagnosis between the two types of familial carriers were not significantly different, with median age of 47 for 1675delA and 52.5 for 1135insA carriers (p = 0.245). For cases ≥50 years at diagnosis, a trend toward longer survival for sporadic over familial cases was observed (p = 0.08). The opposite trend was observed for cases <50 years at diagnosis. There do not seem to be a protective advantage for familial BRCA1 carriers without TP53 mutations over familial cases with TP53 mutations. However, there seem to be a trend towards initial advantage in survival for familial cases compared to sporadic cases diagnosed before the age of 50 both with and without TP53 mutations. However, this trend diminishes over time and for cases diagnosed ≥50 years the sporadic cases show a trend towards an advantage in survival over familial cases. Although this data set is small, if confirmed, this may be a link in the evidence that the differences in ovarian cancer survival reported, are

Riigikogu aseesimeeste valimine tekitas paksu verd : Res Publical riigikogu juhatuses kaks kohta / Katrin Pauts

Index Scriptorium Estoniae

Pauts, Katrin, 1977-

2005-01-01

Riigikogu aseesimeesteks valiti Res Publica liige Taavi Veskimägi ja Keskerakonna liige Toomas Varek. Opositsiooniparteil Res Publica on nüüd juhatuses kaks kohta. Erakondade juhtpoliitikute kommentaare

Human mtDNA hypervariable regions, HVR I and II, hint at deep common maternal founder and subsequent maternal gene flow in Indian population groups.

Science.gov (United States)

Sharma, Swarkar; Saha, Anjana; Rai, Ekta; Bhat, Audesh; Bamezai, Ramesh

2005-01-01

We have analysed the hypervariable regions (HVR I and II) of human mitochondrial DNA (mtDNA) in individuals from Uttar Pradesh (UP), Bihar (BI) and Punjab (PUNJ), belonging to the Indo-European linguistic group, and from South India (SI), that have their linguistic roots in Dravidian language. Our analysis revealed the presence of known and novel mutations in both hypervariable regions in the studied population groups. Median joining network analyses based on mtDNA showed extensive overlap in mtDNA lineages despite the extensive cultural and linguistic diversity. MDS plot analysis based on Fst distances suggested increased maternal genetic proximity for the studied population groups compared with other world populations. Mismatch distribution curves, respective neighbour joining trees and other statistical analyses showed that there were significant expansions. The study revealed an ancient common ancestry for the studied population groups, most probably through common founder female lineage(s), and also indicated that human migrations occurred (maybe across and within the Indian subcontinent) even after the initial phase of female migration to India.

Founder haplotype analysis of Fanconi anemia in the Korean population finds common ancestral haplotypes for a FANCG variant.

Science.gov (United States)

Park, Joonhong; Kim, Myungshin; Jang, Woori; Chae, Hyojin; Kim, Yonggoo; Chung, Nack-Gyun; Lee, Jae-Wook; Cho, Bin; Jeong, Dae-Chul; Park, In Yang; Park, Mi Sun

2015-05-01

A common ancestral haplotype is strongly suggested in the Korean and Japanese patients with Fanconi anemia (FA), because common mutations have been frequently found: c.2546delC and c.3720_3724delAAACA of FANCA; c.307+1G>C, c.1066C>T, and c.1589_1591delATA of FANCG. Our aim in this study was to investigate the origin of these common mutations of FANCA and FANCG. We genotyped 13 FA patients consisting of five FA-A patients and eight FA-G patients from the Korean FA population. Microsatellite markers used for haplotype analysis included four CA repeat markers which are closely linked with FANCA and eight CA repeat markers which are contiguous with FANCG. As a result, Korean FA-A patients carrying c.2546delC or c.3720_3724delAAACA did not share the same haplotypes. However, three unique haplotypes carrying c.307+1G>C, c.1066C > T, or c.1589_1591delATA, that consisted of eight polymorphic loci covering a flanking region were strongly associated with Korean FA-G, consistent with founder haplotypes reported previously in the Japanese FA-G population. Our finding confirmed the common ancestral haplotypes on the origins of the East Asian FA-G patients, which will improve our understanding of the molecular population genetics of FA-G. To the best of our knowledge, this is the first report on the association between disease-linked mutations and common ancestral haplotypes in the Korean FA population. © 2015 John Wiley & Sons Ltd/University College London.

[Professor Adam Nowosławski (1925-2012)--founder of the Polish School of Immunopathology].

Science.gov (United States)

Madaliński, Kazimierz

2012-01-01

Professor dr med. Adam Nowosławski, has died at age of 87, on February 3, 2012, the founder of the Polish school of immunopathology, member of Polish Academy of Sciences and of Polish Academy of Art and Sciences. Professor was born on April 30, 1925 in Rzeszów (SE Poland). During the Second World War he took part in the anti-nazi resistance movement; he was the soldier of the 'Baszta' regiment of the Home Army. Subsequently, he was imprisoned in the Pawiak and concentration camps: Majdanek and Buchenwald. The medical studies he has completed at Warsaw Medical Academy between 1946-1951. The degree of doctor of medicine Prof. Adam Nowosławski has obtained in 1963, habilitation degree in the field of immunopathology--in 1966; the title of Professor he has obtained in 1980. His scientific achievements consist of 170 publications, including 101 original papers. His publications were quoted in several American books for students and physicians. Topics of his early papers concerned the immunopatogenesis ofPneumocystis carinii--induced pneumonia in premature babies, immunopatogenesis of rheumatoid arthritis, and the origin of rheumatoid factor. The enormous role in the field of hepatology played research on the virus of hepatitis B. These studies dealt with the discovery of HB core antigen which had the cellular localization different from HB surface antigen and with the parameters of the immune response to infection. Papers published on this topic were the mostly quoted in the literature and earned him national awards. The activity of Prof. Adam Nowosławski in the field of HIV/AIDS prevention was honored by the special prize of the Minister of Health. Professor was the honorary member of the two Societies: Polish Society of Pathologists and Polish Society of Hepatology. He was also the member of International Association for the Study of the Liver and International Academy of Pathology. Prof. Adam Nowosławski received the national medals: Polonia Restituta Crosses

Estonia : a tie in elections / Kaarel Lahe

Index Scriptorium Estoniae

Lahe, Kaarel

2003-01-01

Autor analüüsib Eesti parlamendivalimiste tulemusi, Res Publica edu võimalikke põhjusi ning prognoosib loodava valitsuskoalitsiooni võimalikke osapooli. Diagramm. Vt. samas: Res Publica - a repetition of the Latvian case?

Staaride värbamine läänelik veidrus / Tuuli Koch

Index Scriptorium Estoniae

Koch, Tuuli

2004-01-01

Modell Carmen Kass astus Res Publica noorteühenduse Juventus liikmeks. Politoloogid ja Res Publica võimupartnerid näevad staaride kaasamises europarlamendi valimiskampaaniasse lääneliku poliitika veidruste ülevõtmist

Rede de colaboração científica sobre oleaginosas envolvidas na produção do biodiesel

Directory of Open Access Journals (Sweden)

Isadora Lucena Andrade

Full Text Available RESUMO Redes de colaboração científica representam estratégias para compartilhamento de informações e novos conhecimentos sobre as comunidades acadêmicas. Este tipo de rede pode identificar os agentes que compõem a rede e a intensidade da ligação que une os atores. Por esta razão, neste trabalho foram identificadas as relações entre os autores, países e instituições em publicações sobre seis oleaginosas pertencentes à cadeia produtiva do biodiesel. As oleaginosas selecionados foram soja, pinhão-manso, dendê, canola, girassol e mamona. Nesta rede, os vértices são autores, países ou instituições e as arestas são obtidas por meio da análise publicação. Portanto, se dois cientistas são coautores em uma publicação, eles estão conectados. As publicações sobre estas seis oleaginosas foram recuperadas da base de dados do Web of Knowledge de 1945 a 2011. As consultas foram feitas no modo de Pesquisa Avançada, procurando o nome da oleaginosa no título da publicação e a palavra biodiesel no título, resumo ou palavras-chave. Para cada oleaginosa, três redes foram construídas: autores, países e instituições. No período estudado, foram analisados um total de 1378 publicações. Quatro países (Brasil, Índia, China e Estados Unidos da América participaram das publicações sobre todas as oleaginosas estudadas.

Educação escolar de mulheres negras: interdições históricas...

Directory of Open Access Journals (Sweden)

Giane Elisa Sales de Almeida

2011-12-01

Full Text Available O artigo aborda aspectos relativos a historia da educação de mulheres negras com base na analise dos fragmentos de memória disponibilizados pelos sujeitos da investigação. Procurando desenhar um perfil do que foi a trajetória educacional desse grupo, particularmente na cidade de Juiz de Fora,no estado brasileiro de Minas Gerais, no período 1950-1970, utilizou-se a historia oral como metodologia. Foram analisados aspectos relativos a cultura escolar e a democratização da escola publica no Brasil, bem como os modos como as políticas publicas voltadas a escolarização interferiram nas historias de vida das mulheres negras. O artigo relaciona as categorias raça, gênero e classe para o entendimento da fruição do direito a cidade e a escola publica como um importante equipamento urbano. Discute os modos como as políticas publicas são apreendidas e os limites interpostos no cotidiano escolar. O artigo aborda aspectos relativos a historia da educação de mulheres negras com base na analise dos fragmentos de memória disponibilizados pelos sujeitos da investigação. Procurando desenhar um perfil do que foi a trajetória educacional desse grupo, particularmente na cidade de Juiz de Fora,no estado brasileiro de Minas Gerais, no período 1950-1970, utilizou-se a historia oral como metodologia. Foram analisados aspectos relativos a cultura escolar e a democratização da escola publica no Brasil, bem como os modos como as políticas publicas voltadas a escolarização interferiram nas historias de vida das mulheres negras. O artigo relaciona as categorias raça, gênero e classe para o entendimento da fruição do direito a cidade e a escola publica como um importante equipamento urbano. Discute os modos como as políticas publicas são apreendidas e os limites interpostos no cotidiano escolar.

Etica publica & buen gobierno

Directory of Open Access Journals (Sweden)

Manjarrez, J.

2007-01-01

Full Text Available Modern societies demand governments promoting equitable and sustainable development and combating corruption. In the different areas of the public administration, factors such as transparency, efficiency, effectiveness, accountability, economy, human rights and respect to the legal framework are of great relevance for a good government. In Mexico it is necessary to reinforce the ethical aspect in the public administration to diminish the level of corruption. The ethical behavior of the public servant is related to integrity, honesty, transparency, expertise and leadership, it is part of the social capital of a country and a necessary condition to a good government and to eradicate corruption. It is essential to establish efficient systems, programs and mechanisms to promote the importance of ethics in government and society. Finally, society must vote to punish or reward the government performance, recognize its social duties and rights, demand the equal exercise of the law and always act ethically.

18 June 2012 - DST Global Founder Y. Milner signing the guest book with Head of International Relations F. Pauss; visiting the AD facility in building 193 with AEGIS Collaboration Spokesperson M. Doser and Adviser for the Russian Federation T. Kurtyka. Managing Director I. Osborne also present with Mrs J. Milner and DST Global A. Lebedkina.

CERN Multimedia

Maximilien Brice

2012-01-01

18 June 2012 - DST Global Founder Y. Milner signing the guest book with Head of International Relations F. Pauss; visiting the AD facility in building 193 with AEGIS Collaboration Spokesperson M. Doser and Adviser for the Russian Federation T. Kurtyka. Managing Director I. Osborne also present with Mrs J. Milner and DST Global A. Lebedkina.

Lotmani kõne ajas erakonnad tülli / Tuuli Koch

Index Scriptorium Estoniae

Koch, Tuuli

2005-01-01

SDE ja Res Publica konfliktist seoses Mihhail Lotmani kõnega vanemahüvitise seaduseelnõu arutelul Riigikogus. Res Publica esimehe Juhan Partsi kirjast SDE esimehele Ivari Padarile, I. Padari vastusest. Lisa: Nestor: kõige tavalisem fašism

Hants Hint - kõigi ihaldatud kaalukeel / Hants Hint ; interv. Erik Gamzejev

Index Scriptorium Estoniae

Hint, Hants

2002-01-01

Ilmunud ka: Severnoje Poberezhje : Laupäev 26. okt. lk. 3. Res Publica Ida-Viru piirkonna juht Hants Hint: me oleme põhimõtteliselt valmis kõigi poliitiliste jõududega koostööd tegema. Autor: Res Publica

La sostenibilidad del recurso hídrico en el Ecuador: análisis multicriterial de la gestión del agua.

OpenAIRE

Rivera Pazmiño, Santiago Israel

2016-01-01

La gestio?n integral del recurso hi?drico representa un vaci?o en la poli?tica pu?blica. La formulacio?n de una poli?tica consistente para su manejo y conservacio?n se ha visto afectada por la gran cantidad de inversio?n pu?blica destinada a la construccio?n de proyectos multipropo?sito. La sostenibilidad del recurso hi?drico en el Ecuador, ana?lisis multicriterial de la gestio?n del agua, evalu?a el impacto de la inversio?n pu?blica en proyectos multipropo?sito y su relacio?n con la segur...

La política ambiental pública en el sector extractivismo petrolero ecuatoriano, con énfasis en áreas naturales protegidas. Caso de estudio: bloque 12-15, empresa pública Petroamazonas.

OpenAIRE

Orbe Bastidas, Sofía Alejandra

2016-01-01

La presente investigacio?n aborda la problema?tica en torno a la poli?tica ambiental pu?blica en el sector extractivo petrolero ecuatoriano, con e?nfasis en a?reas naturales protegidas, el intere?s de esta tesis es estudiar como incide la poli?tica ambiental pu?blica en el marco garantista de derechos en la gestio?n ambiental de la empresa pu?blica Petroamazonas en los Bloques 12 y 15, ya que representa el referente de la gestio?n ambiental “responsable” y “sustentable” de la industria hidroc...

Res Publicat on täna vaja rohkem kui kunagi varem / Taavi Veskimägi

Index Scriptorium Estoniae

Veskimägi, Taavi, 1974-

2005-01-01

Res Publica esimees seab erakonnale ülesandeks selgitada inimestele, et Res Publicat võib usaldada. Ta selgitab, et Res Publica parempoolne poliitika tähendab ka hoolimist nendest, kes ei saa endaga hakkama. Vt. samas: Viimased kampaaniapäevad

Nature of the basement of the East Anatolian plateau: Implications for the lithospheric foundering processes

Science.gov (United States)

Topuz, G.; Candan, O.; Zack, T.; Yılmaz, A.

2017-12-01

Anatolian plateau have resulted from other processes of lithospheric foundering, rather than just slab steepening and break-off. This research is funded by a research grant (#114Y228) from TÜBİTAK.

Blue eye color in humans may be caused by a perfectly associated founder mutation in a regulatory element located within the HERC2 gene inhibiting OCA2 expression

DEFF Research Database (Denmark)

Eiberg, Hans; Troelsen, Jesper; Boyd, Mette

2008-01-01

The human eye color is a quantitative trait displaying multifactorial inheritance. Several studies have shown that the OCA2 locus is the major contributor to the human eye color variation. By linkage analysis of a large Danish family, we finemapped the blue eye color locus to a 166 Kbp region...... within the HERC2 gene. By association analyses, we identified two SNPs within this region that were perfectly associated with the blue and brown eye colors: rs12913832 and rs1129038. Of these, rs12913832 is located 21.152 bp upstream from the OCA2 promoter in a highly conserved sequence in intron 86...... founder mutation in an OCA2 inhibiting regulatory element as the cause of blue eye color in humans. In addition, an LOD score of Z = 4.21 between hair color and D14S72 was obtained in the large family, indicating that RABGGTA is a candidate gene for hair color....

The Global Financial Crisis: Analysis and Policy Implications

Science.gov (United States)

2009-05-12

Ministerio de Economia y Finanzas Publicas. Instituto Nacional de Estadistica y Censos (INDEC). Utilizacion de la Capacidid Instalada en la Industria...2008 and International Monetary Fund. Global Markets Monitor. March 17, 2009. 102 Republica Argentina. Ministerio de Economia y Finanzas Publicas

Perfil da publicação científica brasileira sobre a temática da classe hospitalar Profile of Brazilian scientific publications on the subject of hospital shooling

Directory of Open Access Journals (Sweden)

Alessandra Santana Soares e Barros

2011-08-01

Full Text Available O objetivo do trabalho foi descrever o perfi l da publicação científi ca brasileira sobre a temática da escolarização em hospitais, iniciativa justifi cada a partir do reconhecimento da importância da produção científi ca na legitimação e consolidação de uma nova área do saber. Foram analisados 47 artigos publicadosem periódicos científi cos entre os anos de 1997 e 2008. Tratou-se, basicamente, de um estudo de avaliação do Estado do Conhecimento (ou Estado da Arte de uma área de interesse crescente dentro da Educação Especial: a escolarização de crianças hospitalizadas e/ou doentes crônicas, designada pelo MEC segundo o termo Classe Hospitalar. Do ponto de vista do corpus empírico, tratou-se de uma pesquisa documental, alicerçada metodologicamente na Análise de Conteúdo. Os artigos da amostra foram quantifi cados e qualifi cados segundo o tipo de investimento empírico predominante, quais fossem: ensaio, relato de experiência, relatos de pesquisa original (pesquisa com desenho de investigação ou revisão de literatura. Buscou-se, também, identifi car se o periódico ao qual o artigo pertencia encontrava-se indexado em bases de dados: SciELO, Edubase, Bireme e catálogo do INEP. Descreveu-se, ainda, a distribuição dos artigos por área de conhecimento e por instituições de onde provinham. Os principais resultados obtidos revelaram que dos 47 artigos analisados 22 foram classifi cados como sendo oriundos de pesquisa original, apenas dois periódicos encontravam-se indexados em todas as bases de dados consideradas em relevância e as publicações foram originadas, em sua grande parte, da atividade de pesquisadores estabelecidos em instituições federais de ensino superior.The aim of this paper was to describe the profi le of Brazilian scientifi c publications on the topic of education in hospitals, an initiative justifi ed since the recognition of the importance of scientifi c output in legitimizing and

Regional Joint Border Commands: A Pathway to Improving Collaboration and Effectiveness for Border Control

Science.gov (United States)

2009-12-01

Police xii SBI Secure Border Initiative SES Senior Executive Service SSP Secretaria de Seguridad Publica TSA Transportation Security...also been involvement from the Mexican law enforcement agency, Secretaria de Seguridad Publica (SSP) on the southwest border (CBP, 2009; ICE, 2009, p. 5

Mapping of epistemological approaches on publications on the organizational strategy field Mapeamento de abordagens epistemológicas em publicações sobre estratégia organizacional

Directory of Open Access Journals (Sweden)

Renê Birochi

2013-03-01

Full Text Available This paper aims to conduct a study about the major epistemological approaches, identified in articles on the subject of organizational strategy. The theoretical framework that guided this research is based on the classical definition proposed by Burrell and Morgan (1979 about the four paradigms of social science research. We investigated articles in the area of Administration, Accounting and Tourism, published in Brazilian journals between the years 2001 to 2012, classified as "B1" and "B2" in accordance with Qualis / CAPES criteria. In order to meet this goal, we performed a bibliometric study to map the selected publications. As a result of this study, there was a predominance of the functionalist paradigm, as well as a reduced presence of articles which explain their theoretical and methodological choices as the foundation for their empirical studies.Este artigo tem como objetivo realizar um estudo sobre as principais abordagens epistemológicas, identificadas em artigos sobre o tema da estratégia organizacional. O referencial teórico que guiou esta investigação é baseado na clássica definição proposta por Burrell e Morgan (1979 a respeito dos quatro paradigmas de pesquisa em ciências sociais. Foram investigados artigos da área de Administração, Ciências Contábeis e Turismo, publicados em periódicos nacionais entre os anos de 2001 a 2012, nos estratos B1 e B2 do sistema Qualis/Capes. Visando a atender este objetivo, foi realizado um estudo bibliométrico para mapear as publicações selecionadas. Como resultado deste estudo, constatou-se a predominância do paradigma funcionalista, assim como uma reduzida presença de artigos que explicitam as suas escolhas teórico-metodológicas, como fundamento para seus estudos empíricos. 

Analüütikud ennustavad Res Publicale mõõnast pääsu / Rasmus Kagge

Index Scriptorium Estoniae

Kagge, Rasmus, 1977-

2005-01-01

Poliitikavaatlejate hinnangul ületab Res Publica mõõna ja saab järgmistel parlamendivalimistel kuni 12 kohta, kui nad loobuvad "uue poliitika" stiilis loosungitest ja kõrkusest. Lisa: Mõõna põhjusi. Vt. samas: Taavi Veskimägi lubas lõpetada Res Publica peataoleku

A savoir against barbary: begginings of the popularization of science in the platino space of Uruguay and Brasil

OpenAIRE

Silveira, Ada Cristina Machado de; Gripp, Phillip Días

2015-01-01

O artigo estrutura elementos históricos no aparecimento de publicações dedicado à cultura científica no Uruguai e na região da Campanha no Estado brasileiro de Rio Grande faça Sul e é interrogado sobre os vínculos existentes naquele espaço platino e que favoreceram o surgimento de duas publicações especializadas analisadas em sua vontade de saber e de poder. Eles se salientam aspectos da revista uruguaia La Propaganda Rural e as publicações criadas por uma associação de produtores sul-brasile...

RESINAS COMPOSTAS EM DENTES POSTERIORES: UMA REVISÃO SISTEMÁTICA

OpenAIRE

Lima, Cláudia Fonseca de Albuquerque; de Souza, Fábio Barbosa; da Silva, Claudio Heliomar Vicente

2016-01-01

As resinas compostas vêm sendo largamente utilizadas em dentes posteriores. Objetivou-se realizar uma revisão sistemática acerca das publicações de avaliações clínicas do emprego deste material em restaurações que envolvessem a superfície oclusal e/ou proximal de pré-molares e molares de forma a avaliar os critérios empregados para execução das mesmas. As publicações foram selecionadas aleatoriamente a partir de uma pesquisa bibliográfica a partir dos pré-requisitos: publicação em revista ind...

The initiation of lateral roots in the primary roots of maize (Zea mays L.) implies a reactivation of cell proliferation in a group of founder pericycle cells.

Science.gov (United States)

Alarcón, M Victoria; Lloret, Pedro G; Martín-Partido, Gervasio; Salguero, Julio

2016-03-15

The initiation of lateral roots (LRs) has generally been viewed as a reactivation of proliferative activity in pericycle cells that are committed to initiate primordia. However, it is also possible that pericycle founder cells that initiate LRs never cease proliferative activity but rather are displaced to the most distal root zones while undertaking successive stages of LR initiation. In this study, we tested these two alternative hypotheses by examining the incorporation of 5-bromo-2'-deoxyuridine (BrdU) into the DNA of meristematic root cells of Zea mays. According to the values for the length of the cell cycle and values for cell displacement along the maize root, our results strongly suggest that pericycle cells that initiate LR primordia ceased proliferative activity upon exiting the meristematic zone. This finding is supported by the existence of a root zone between 4 and 20mm from the root cap junction, in which neither mitotic cells nor labelled nuclei were observed in phloem pericycle cells. Copyright © 2016 Elsevier GmbH. All rights reserved.

Entrepreneurial Choices of Initial Human Capital Endowments and New Venture Success

DEFF Research Database (Denmark)

Rocha, Vera; Van Praag, Mirjam; B. Folta, Timothy

The founder (team)'s human capital is a vital determinant of future firm performance. This is a stylized fact. Less is known about the effect of the human capital of the initial workforce hired by the founder(s). We study the performance consequences of a founder's choice of the initial workforce......'s human capital (quantity and quality), besides the human capital of the founder(s). The analysis is based on matched employer-employee data and covers about 5,300 startups in manufacturing industries founded by individuals coming from employment between 1992 and 2007. We acknowledge that initial hiring...... decisions are endogenous and correlated with the human capital of the founders and the ownership structure of startups (single founder versus team of founders). Given the stickiness of initial choices, human capital decisions at entry turn out to be a close to irreversible matter with significant...

Kas erakonnad läksid tülli? / Mihhail Lotman

Index Scriptorium Estoniae

Lotman, Mihhail, 1952-

2005-01-01

Riigikogu Res Publica fraktsiooni liikme hinnangul ei ole nn. vanad erakonnad unustanud eelmistel Riigikogu valimistel saadud kaotust Res Publicale, nende meelest on Res Publica poliitikud liiga noored ja kogenematud. Kuid autori hinnangul pole erakonnad emotsionaalselt tülli läinud ning vastuoludest saadakse üle

Cambio cultural y formación en las organizaciones públicas

Directory of Open Access Journals (Sweden)

JOSÉ LUIS VEIRA

1997-01-01

Full Text Available la distincion entre organizaciones publicas y privadas es confusa. detras de esta ambigüedad estan la expansion de los servicios publicos mas alla de lo que se venia entendiendo como el core del sector publico, y los procesos de privatizacion. estas dos tendencias de signo contrario tienen un impacto similar en el cambio cultural de las organizaciones publicas. desde los años ochenta los valores asociados al mercado han incrementado su influencia en el sector publico. ello implica la asimilacion de valores del management privado, tales como la competencia y la productividad, pero que no siempre son compatibles con los fines de la funcion publica como el control legal y la justicia. la formacion futura del funcionariado debera resolver estas contradicciones en un nuevo codigo de conducta para la vida publica. en el sector publico no basta con la eficiencia, tambien es necesario respetar el interes general y el control legal.

Writing for international publication in nursing journals: a personal perspective (part 1 Como escribir para publicacion en enfermeria: una perspectiva personal (parte 1 Como escrever para publicação internacional em enfermagem: uma perspectiva pessoal (parte 1

Directory of Open Access Journals (Sweden)

G. Hussein Rassool

2006-04-01

. Nuestro desafío en América Latina es fomentar el desarrollo de artículos para publicación impresa o no en revistas con revisores internacionales. La co-autoría ofrece un modelo potencialmente alentador tanto para el investigador como para el alumno de postgrado publicar. Esa tarea puede ser emprendida con la ayuda de supervisores internacionales e investigadores o estudiantes de postgrado que dominan la lengua inglesa. Este artículo intenta desvelar el proceso de publicación y presentar algunos principios directivos de como publicar en revistas internacionales.O número de meios de divulgação acadêmica impressa e eletrônica (Internet de enfermagem de abrangência nacional e internacional destaca a importância de publicar entre enfermeiros. Ao redor do mundo, as revistas estão sendo categorizadas em relação a méritos para a profissão e avaliação por pares. Cada vez mais, as instituições de financiamento de pesquisa estão atentas à publicação em revistas de prestígio acadêmico como um dos critérios para a concessão do mesmo. Um fator importante a ser considerado entre as razões para que muitos artigos científicos falham no preenchimento dos requisitos de avaliação dos revisores de revistas internacionais, principalmente aquelas de idioma inglês, é a tradução pobre e de modo literal. Nosso desafio na América Latina é incrementar o desenvolvimento de artigos para publicação impressa ou não em revistas com revisores internacionais. A co-autoria oferece um modelo potencialmente encorajador tanto para o pesquisador como para o pós-graduando publicar. Esse objetivo pode ser empreendido com a ajuda de supervisores internacionais e pesquisadores, orientadores ou estudantes de pós-graduação conhecedores da língua inglesa. O presente artigo busca desmistificar o processo de publicação e apresentar alguns princípios norteadores de como publicar em revistas internacionais.

Writing for international publication in nursing journals: a personal perspective (Part 2 Como escribir para publicacion en enfermeria: una perspectiva personal (Parte 2 Como escrever para publicação internacional em enfermagem: uma perspectiva pessoal (Parte 2

Directory of Open Access Journals (Sweden)

G. Hussein Rassool

2006-06-01

. Nuestro desafío en América Latina es fomentar el desarrollo de artículos para publicación impresa o no en revistas con revisores internacionales. La co-autoría ofrece un modelo potencialmente alentador tanto para el investigador como para el alumno de postgrado publicar. Esa tarea puede ser emprendida con la ayuda de supervisores internacionales e investigadores o estudiantes de postgrado que dominan la lengua inglesa. Este artículo intenta desvelar el proceso de publicación y presentar algunos principios directivos de como publicar en revistas internacionales.O número de meios de divulgação acadêmica impressa e eletrônica (Internet de enfermagem de abrangência nacional e internacional destaca a importância de publicar entre enfermeiros. Ao redor do mundo, as revistas estão sendo categorizadas em relação a méritos para a profissão e avaliação por pares. Cada vez mais, as instituições de financiamento de pesquisa estão atentas à publicação em revistas de prestígio acadêmico como um dos critérios para a concessão do mesmo. Um fator importante a ser considerado entre as razões para que muitos artigos científicos falham no preenchimento dos requisitos de avaliação dos revisores de revistas internacionais, principalmente aquelas de idioma inglês, é a tradução pobre e de modo literal. Nosso desafio na América Latina é incrementar o desenvolvimento de artigos para publicação impressa ou não em revistas com revisores internacionais. A co-autoria oferece um modelo potencialmente encorajador tanto para o pesquisador como para o pós-graduando publicar. Esse objetivo pode ser empreendido com a ajuda de supervisores internacionais e pesquisadores, orientadores ou estudantes de pós-graduação conhecedores da língua inglesa. O presente artigo busca desmistificar o processo de publicação e apresentar alguns princípios norteadores de como publicar em revistas internacionais.

A deep intronic CLRN1 (USH3A) founder mutation generates an aberrant exon and underlies severe Usher syndrome on the Arabian Peninsula.

Science.gov (United States)

Khan, Arif O; Becirovic, Elvir; Betz, Christian; Neuhaus, Christine; Altmüller, Janine; Maria Riedmayr, Lisa; Motameny, Susanne; Nürnberg, Gudrun; Nürnberg, Peter; Bolz, Hanno J

2017-05-03

Deafblindness is mostly due to Usher syndrome caused by recessive mutations in the known genes. Mutation-negative patients therefore either have distinct diseases, mutations in yet unknown Usher genes or in extra-exonic parts of the known genes - to date a largely unexplored possibility. In a consanguineous Saudi family segregating Usher syndrome type 1 (USH1), NGS of genes for Usher syndrome, deafness and retinal dystrophy and subsequent whole-exome sequencing each failed to identify a mutation. Genome-wide linkage analysis revealed two small candidate regions on chromosome 3, one containing the USH3A gene CLRN1, which has never been associated with Usher syndrome in Saudi Arabia. Whole-genome sequencing (WGS) identified a homozygous deep intronic mutation, c.254-649T > G, predicted to generate a novel donor splice site. CLRN1 minigene-based analysis confirmed the splicing of an aberrant exon due to usage of this novel motif, resulting in a frameshift and a premature termination codon. We identified this mutation in an additional two of seven unrelated mutation-negative Saudi USH1 patients. Locus-specific markers indicated that c.254-649T > G CLRN1 represents a founder allele that may significantly contribute to deafblindness in this population. Our finding underlines the potential of WGS to uncover atypically localized, hidden mutations in patients who lack exonic mutations in the known disease genes.

Criatividade no contexto educacional: análise de publicações periódicas e trabalhos de pós-graduação na área da psicologia Creativity in educational context: analysis of periodical publications and graduate works in the field of psychology

Directory of Open Access Journals (Sweden)

Talita Fernanda da Silva

2012-09-01

Full Text Available Atualmente, o número de estudos sobre criatividade desenvolvidos no contexto educacional vem-se ampliando, dada a constatação de sua importância tanto para os avanços almejados na educação, quanto para o desenvolvimento do estudante. Nesse sentido, o presente estudo teve como objetivo investigar a produção científica sobre criatividade no contexto educacional dos últimos quinze anos (1995-2009, por meio da análise de publicações periódicas e trabalhos de pós-graduação na área da psicologia. Após consulta a quatro bancos de dados, 82 trabalhos foram analisados em relação ao ano de publicação, à região do país a que pertence o pesquisador, ao nível do trabalho, à temática abordada e ao tipo de pesquisa, de amostra e de instrumentos utilizados. Os resultados mostraram, de maneira geral, um crescimento no número de publicações a partir do ano 2000. A maior parte dos trabalhos vem sendo desenvolvida por pesquisadores das regiões Sudeste e Centro-Oeste; a maioria deles é de cunho empírico, com foco de investigação, em primeiro lugar, na população adulta e, em segundo, na população infantil, envolvendo principalmente professores de ensino fundamental e seus alunos. Dentre os instrumentos que têm sido empregados para avaliação da criatividade no contexto educacional destacam-se o Inventário de barreiras à criatividade pessoal, os Testes de Pensamento Criativo de Torrance e a Checklist de barreiras à promoção da criatividade em sala de aula. A análise demonstrou que, embora se possa notar um aumento no número de trabalhos desenvolvidos no ambiente escolar, lacunas ainda existem em relação a estudos que investiguem essa característica em amostras minoritárias (alunos com deficiência, alunos com altas habilidades, idosos em universidades de terceira idade, espaços não formais de aprendizagem.Currently, the number of studies on creativity implemented in the educational context is increasing, as more

Counternarcotic Efforts in the Southern Cone: Chile

Science.gov (United States)

1990-06-30

within its scope is drug trafficking. -. The Ministry of Health. The Instituto de Salud Publica (National Institute of Public Heath, part of the...Instituto de Salud Publica ) issued a writen reply to a questionaire. Additional information on health matters was provided by Dr. Roberto Laihacar, psychiatrist of the Military Hospital in Santiago. 37

Sociedad mundial 2050 : una visión prospectiva para su gestión : una via para crear un mejor mañana /

OpenAIRE

Montero Olivares, Sergio

2013-01-01

 tesis que para obtener el grado de Doctorado en Administración Publica, presenta Sergio Montero Olivares ; tutor principal de tesis German Pérez Fernández del Castillo. 403 páginas : ilustraciones. Doctorado en Administración Publica Universidad Nacional Autónoma de México, 2013

Founder representation and effective population size in old versus young breeds-genetic diversity of Finnish and Nordic Spitz.

Science.gov (United States)

Kumpulainen, M; Anderson, H; Svevar, T; Kangasvuo, I; Donner, J; Pohjoismäki, J

2017-10-01

Finnish Spitz is 130-year-old breed and has been highly popular in Finland throughout its history. Nordic Spitz is very similar to Finnish Spitz by origin and use, but is a relatively recent breed with much smaller population size. To see how breed age and breeding history have influenced the current population, we performed comprehensive population genetic analysis using pedigree data of 28,119 Finnish and 9,009 Nordic Spitzes combined with genomewide single nucleotide polymorphism (SNP) data from 135 Finnish and 110 Nordic Spitzes. We found that the Finnish Spitz has undergone repeated male bottlenecks resulting in dramatic loss of genetic diversity, reflected by 20 effective founders (f a ) and mean heterozygosity (Hz) of 0.313. The realized effective population size in the breed based on pedigree analysis (N¯ec) is 168, whereas the genetic effective population size (N eg ) computed the decay of linkage disequilibrium (r 2 ) is only 57 individuals. Nordic Spitz, although once been near extinction, has not been exposed to similar repeated bottlenecks than Finnish Spitz and had f a of 27 individuals. However, due to the smaller total population size, the breed has also smaller effective population size than Finnish Spitz (N¯ec = 98 and N eg  = 49). Interestingly, the r 2 data show that the effective population size has contracted dramatically since the establishment of the breed, emphasizing the role of breed standards as constrains for the breeding population. Despite the small population size, Nordic Spitz still maintains SNP heterozygosity levels similar to mixed breed dogs (mean Hz = 0.409). Our study demonstrates that although pedigree analyses cannot provide estimates of the present diversity within a breed, the effective population sizes inferred from them correlate with the genotyping results. The genetic relationships of the northern Spitz breeds and the benefits of the open breed registry are discussed. © 2017 Blackwell Verlag GmbH.

Maracujá-doce: o autor, a obra e a data da publicação de Passiflora alata (Passifloraceae Sweet-passion-fruit: the autor, data and publication of the scientific name of Passiflora alata (Passifloraceae

Directory of Open Access Journals (Sweden)

Luís Carlos Bernacci

2003-08-01

Full Text Available O maracujazeiro-doce (Passiflora alata Curtis é uma espécie nativa da América do Sul, especialmente do Brasil, cujo cultivo tem se expandido em função do preço alcançado pelos frutos. Vários trabalhos de pesquisa foram realizados com esta espécie, quase todos com imprecisões na citação do nome científico. Com o objetivo de avaliar a extensão desses equívocos e identificar a forma cientificamente correta de citar a espécie, foram investigados o autor e a data de publicação do nome científico do maracujá-doce, em estudos taxonômicos. Concluiu-se que a espécie deve ser citada como Passiflora alata Curtis, conforme publicado originalmente em 1788, no periódico Botanical Magazine.The author, data and publication of the scientific name of the sweet passion-fruit had been investigated. A series of mistakes occurred in relation to the correct citation of the species. The aim of the present paper was to evaluate the problems and identify the scientific correct form of Passiflora alata nomenclature. The species must be cited as Passiflora alata Curtis and was published originally in 1788, in the Botanical Magazine.

A presença de Francisco Ferrer nas publicações de Maurício Tragtenberg pela Revista Educação e Sociedade (1978 - 2008 = The presence of Francisco Ferrer in Maurício Tragtenberg’s publications by Journal Educação & Sociedade (1978 - 2008.

Directory of Open Access Journals (Sweden)

Lenildes Ribeiro Silva

2011-01-01

Full Text Available Este trabalho tem por objetivo compreender as relações entre o pensamento de Maurício Tragtenberg e o ideário da "Escola Moderna" de Francisco Ferrer y Guardia, no início do século XX, baseando-se nas publicações de Tragtenberg pela Revista "Educação e Sociedade" (1978-2008. Nessas publicações, intenta-se ressaltar as aproximações do pensamento entre os dois autores na defesa de uma educação voltada aos interesses do operariado, tornando-o uma classe consciente dos processos de dominação da sociedade capitalista e das possibilidades de superação. Na denúncia da monopolização do conhecimento sob interesses particulares, preconceituosos e excludentes, sejam religiosos ou na forma laica do Estado burguês, a educação defendida pelos autores visa conduzir o povo pela via da conscientização, autonomia e autogestão, necessárias a uma verdadeira democracia. Contra o treinamento, a obediência e a manipulação ideológica, os autores convergem na defesa de uma educação no sentido da liberdade, da crítica e da solidariedade.This paper seeks to understand the relationship between the thinking of Maurício Tragtenberg and the ideals of the Modern School of Francisco Ferrer y Guardia in the early 20th century, based on the analysis of Tragtenberg’s publications in the journal “Educação and Sociedade” (1978-2008. In these publications, emphasis is given to the approximations between the thoughts of the two authors in defense of an education focused on the interests of the working class, making it a class conscious of the domination processes of capitalist society as well as the possibilities of overcoming them. By denouncing the monopolization of knowledge by private, prejudiced and exclusionary interests – whether religious or in the secular form of the bourgeois state – the education advocated by the authors seeks to lead people through awareness, autonomy and self-management, all of which are necessary for a

Recurrent missense mutations in TMEM43 (ARVD5) due to founder effects cause arrhythmogenic cardiomyopathies in the UK and Canada

KAUST Repository

Haywood, Annika; Merner, Nancy D.; Hodgkinson, Kathy A.; Houston, Jim; Syrris, Petros; Booth, Valerie; Connors, Sean; Pantazis, Antonios; Quarta, Giovanni; Elliott, Perry; McKenna, William; Young, Terry Lynn

2012-01-01

AimsAutosomal dominant arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) (in the group of arrhythmogenic cardiomyopathies) is a common cause of sudden cardiac death in young adults. It is both clinically and genetically heterogeneous, with 12 loci (ARVC/D1-12) and eight genes identified, the majority of which encode structural proteins of cardiac desmosomes. The most recent gene identified, TMEM43, causes disease due to a missense mutation in a non-desmosomal gene (p.S358L) in 15 extended families from Newfoundland, Canada. To determine whether mutations in TMEM43 cause ARVC/D and arrhythmogenic cardiomyopathy in other populations, we fully re-sequenced TMEM43 on 143 ARVC/D probands (families) from the UK and 55 probands (from 55 families) from Newfoundland.Methods and resultsBidirectional sequencing of TMEM43 including intron-exon boundaries revealed 33 variants, the majority located in non-coding regions of TMEM43. For the purpose of validation, families of probands with rare, potentially deleterious coding variants were subjected to clinical and molecular follow-up. Three missense variants of uncertain significance (p.R28W, p.E142K, p.R312W) were located in highly conserved regions of the TMEM43 protein. One variant (p.R312W) also co-segregated with relatives showing clinical signs of disease. Genotyping and expansion of the disease-associated haplotype in subjects with the p.R312W variant from Newfoundland, Canada, and the UK suggest common ancestry.ConclusionAlthough the p.R312W variant was found in controls (3/378), identification of an ancestral disease p R312W haplotype suggests that the p.R312W variant is a pathogenic founder mutation. © 2012 The Author.

Recurrent missense mutations in TMEM43 (ARVD5) due to founder effects cause arrhythmogenic cardiomyopathies in the UK and Canada

KAUST Repository

Haywood, Annika

2012-11-15

AimsAutosomal dominant arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) (in the group of arrhythmogenic cardiomyopathies) is a common cause of sudden cardiac death in young adults. It is both clinically and genetically heterogeneous, with 12 loci (ARVC/D1-12) and eight genes identified, the majority of which encode structural proteins of cardiac desmosomes. The most recent gene identified, TMEM43, causes disease due to a missense mutation in a non-desmosomal gene (p.S358L) in 15 extended families from Newfoundland, Canada. To determine whether mutations in TMEM43 cause ARVC/D and arrhythmogenic cardiomyopathy in other populations, we fully re-sequenced TMEM43 on 143 ARVC/D probands (families) from the UK and 55 probands (from 55 families) from Newfoundland.Methods and resultsBidirectional sequencing of TMEM43 including intron-exon boundaries revealed 33 variants, the majority located in non-coding regions of TMEM43. For the purpose of validation, families of probands with rare, potentially deleterious coding variants were subjected to clinical and molecular follow-up. Three missense variants of uncertain significance (p.R28W, p.E142K, p.R312W) were located in highly conserved regions of the TMEM43 protein. One variant (p.R312W) also co-segregated with relatives showing clinical signs of disease. Genotyping and expansion of the disease-associated haplotype in subjects with the p.R312W variant from Newfoundland, Canada, and the UK suggest common ancestry.ConclusionAlthough the p.R312W variant was found in controls (3/378), identification of an ancestral disease p R312W haplotype suggests that the p.R312W variant is a pathogenic founder mutation. © 2012 The Author.

The roles of geography and founder effects in promoting host-associated differentiation in the generalist bogus yucca moth Prodoxus decipiens.

Science.gov (United States)

Darwell, C T; Fox, K A; Althoff, D M

2014-12-01

There is ample evidence that host shifts in plant-feeding insects have been instrumental in generating the enormous diversity of insects. Changes in host use can cause host-associated differentiation (HAD) among populations that may lead to reproductive isolation and eventual speciation. The importance of geography in facilitating this process remains controversial. We examined the geographic context of HAD in the wide-ranging generalist yucca moth Prodoxus decipiens. Previous work demonstrated HAD among sympatric moth populations feeding on two different Yucca species occurring on the barrier islands of North Carolina, USA. We assessed the genetic structure of P. decipiens across its entire geographic and host range to determine whether HAD is widespread in this generalist herbivore. Population genetic analyses of microsatellite and mtDNA sequence data across the entire range showed genetic structuring with respect to host use and geography. In particular, genetic differentiation was relatively strong between mainland populations and those on the barrier islands of North Carolina. Finer scale analyses, however, among sympatric populations using different host plant species only showed significant clustering based on host use for populations on the barrier islands. Mainland populations did not form population clusters based on host plant use. Reduced genetic diversity in the barrier island populations, especially on the derived host, suggests that founder effects may have been instrumental in facilitating HAD. In general, results suggest that the interplay of local adaptation, geography and demography can determine the tempo of HAD. We argue that future studies should include comprehensive surveys across a wide range of environmental and geographic conditions to elucidate the contribution of various processes to HAD. © 2014 European Society For Evolutionary Biology. Journal of Evolutionary Biology © 2014 European Society For Evolutionary Biology.

Founders Online Metadata

Data.gov (United States)

National Archives and Records Administration — CORRESPONDENCE AND OTHER WRITINGS OF SIX MAJOR SHAPERS OF THE UNITED STATES: George Washington, Benjamin Franklin, John Adams (and family), Thomas Jefferson,...

Eduardo Primo Yúfera, founder of Revista de Agroquímica y Tecnología de Alimentos and pioneer on food science and technology research in Spain.

Science.gov (United States)

Ayala-Gascón, M; Aleixandre-Benavent, R; Gandía-Balaguer, A

2011-12-01

Eduardo Primo Yúfera was the founder and director of the Instituto de Agroquímica y Tecnología de Alimentos (IATA, 1957-1974) until he was appointed president of the Consejo Superior de Investigaciones Científicas (CSIC). His aim to publicize food science led him to create the Revista de Agroquímica y Tecnología de Alimentos in 1961, the forerunner of this journal, Food Science and Technology International, which he directed until 1977. Of his scientific output, 50% has been published in this journal. He is considered to be the promoter and exponent of Food Science and Technology and Chemical Ecology in Spain as well as the instigator of the country's innovation model (R&D and innovation). In his work, he was able to combine basic research excellence and socially relevant applied research to move both science and society forward. He was an example and inspiration to many colleagues and followers. The aim of this study is to highlight the influence and importance of Primo Yúfera in the formation, development and consolidation of the journal Revista de Agroquímica y Tecnología de Alimentos, and to appraise his scientific contribution to this journal.

The size of second chambers and European assemblies / Rein Taagepera, Steven P Recchia

Index Scriptorium Estoniae

Taagepera, Rein, 1933-

2002-01-01

Autorid võrdlevad eri maade esinduskogude kodade suurust ja elanike arvu neis maades ning arutlevad, kui suur kohtade arv peaks olema Euroopa Liidu Nõukogus ja Euroopa Parlamendis. Tabelid, diagrammid

90-letnij yubilej osnovatelya IAI Petra Grigor'evicha Kulikovskogo %t The founder of "Studies in the history of astronomy" Dr. P. G. Kulikovsky: to his 90th birthday

Science.gov (United States)

Eremeeva, A. I.; Laerova, N. B.; Samus', N. N.

On June 13, 2000, Moscow astronomers congratulated personally P. G. Kulikovsky, the renowned Russian astronomer and teacher of astronomy on his birthday. Born in Kiev in a family with noble Polish and French roots, he graduated from Moscow University in 1938 and worked at Sternberg Astronomical Institute and the Department of Astronomy of Moscow University. His main scientific interests are Galactic astronomy and history of astronomy. Kulikovsky was one of the pioneers of astronomical electrophotometry in the Soviet Union. He was most active in studies of variable stars, investigated connections of their statistical properties with those of the corresponding stars systems. Being a brilliant teacher, he lectured successfully on astronomical subjects in Moscow University. Friends also know him as a talented musician and composer, an author of many piano plays. Kulikovsky has done very much as an organizer of Soviet systematic researches on the history of astronomy. He is the author of many papers on the subject, the founder of the corresponding commission of the USSR Astronomical Council. Kulikovsky was an active member of the IAU, he served as President of the IAU Commission 41 (History of Astronomy) in 1958 - 1964.

Mexico’s National Command and Control Center Challenges and Successes

Science.gov (United States)

2011-06-01

law enforcement agencies. The NAS funding has enabled major Mexican Law Enforcement agency such as Secretaria Seguridad de Publica (SSP) to adopt...Secretaria Seguridad de Publica (SSP) orSecretary of Public Security – Lead Agency, responsable forlawenforcment and druingmajordisasters and...Perales Pimentel Ing. Francisco Niembro Maribel Cervates Guerrero Genaro Garcia Luna Secretaría de Seguridad Pública Mexico, D.F. Point of

BRCA Genetic Screening in Middle Eastern and North African: Mutational Spectrum and Founder BRCA1 Mutation (c.798_799delTT in North African

Directory of Open Access Journals (Sweden)

Abdelilah Laraqui

2015-01-01

Full Text Available Background. The contribution of BRCA1 mutations to both hereditary and sporadic breast and ovarian cancer (HBOC has not yet been thoroughly investigated in MENA. Methods. To establish the knowledge about BRCA1 mutations and their correlation with the clinical aspect in diagnosed cases of HBOC in MENA populations. A systematic review of studies examining BRCA1 in BC women in Cyprus, Jordan, Egypt, Lebanon, Morocco, Algeria, and Tunisia was conducted. Results. Thirteen relevant references were identified, including ten studies which performed DNA sequencing of all BRCA1 exons. For the latter, 31 mutations were detected in 57 of the 547 patients ascertained. Familial history of BC was present in 388 (71% patients, of whom 50 were mutation carriers. c.798_799delTT was identified in 11 North African families, accounting for 22% of total identified BRCA1 mutations, suggesting a founder allele. A broad spectrum of other mutations including c.68_69delAG, c.181T>G, c.5095C>T, and c.5266dupC, as well as sequence of unclassified variants and polymorphisms, was also detected. Conclusion. The knowledge of genetic structure of BRCA1 in MENA should contribute to the assessment of the necessity of preventive programs for mutation carriers and clinical management. The high prevalence of BC and the presence of frequent mutations of the BRCA1 gene emphasize the need for improving screening programs and individual testing/counseling.

CORRELAÇÃO ENTRE PUBLICAÇÕES CIENTÍFICAS E PATENTES COM CÉLULAS-TRONCO PLURIPOTENTE INDUZIDAS (iPS: BASES PARA UMA PROSPECÇÃO TECNOLÓGICA

Directory of Open Access Journals (Sweden)

Maria Acelina Carvalho

2014-12-01

Full Text Available A reprogramação de células somáticas para uma célula pluripotente indiferenciada, com características de uma célula-tronco embrionária (CTE, é um dos avanços promissores no campo da biologia celular na última década. O objetivo desse trabalho foi reunir informações como base de uma prospecção tecnológica prévia sobre o tema células-tronco pluripotente induzidas (iPS e verificar se existe correlação entre o número de publicações científicas e número de patentes na referida área. Foram pesquisadas patentes depositadas no EPO, USPTO e INPI e publicações científicas na base de dados Web of Science com a finalidade de realizar a correlação entre a quantidade de publicações científicas e o número de patentes depositados por ano e por países .A Organização Mundial de Propriedade Intelectual (WO seguida dos Estados Unidos e China detém os maiores números de patentes depositadas envolvendo iPS. Observa-se que as patentes envolvendo iPS aparecem a partir de 2007 com uma única patente japonesa registrada no INPI. Os EUA lidera o número de publicações científicas sobre iPS com 1.679 publicações na base de dados Web of Science.

Colombia: Learning Institutions Enable Integrated Response

Science.gov (United States)

2010-09-01

publica - tions of the “human rights cartel.” The frames whereby the parastates assessed the conflict remained virtually unchanged, and in some cases...Politica de Defensa y 144 | FRoM the FIeld PRISM 1, no. 4 Seguridad Democratica, requires slightly more pages for its presentation but is identical...capability” to “establish security force presence throughout the country” (lograr presencia fuerza publica en todo territorio nacional). Though a

A Study on the Bionomics of Anopheles darlingi Root (Diptera: Culicidae) in Belize, Central America

Science.gov (United States)

2004-03-01

Mosquitoes of medical importance. U.S. Dep. Agric. Agric. Handb. 152. Forattini, O.P. 1962. Entomologia medica vol. I. Faculdade de Higiene e Saude Publica...meridional do Brasil. Rev. Saude Publ., S. Paulo. 21: 291-304. Forattini, O.P. 1962. Entomologia medica vol. I. Faculdade de Higiene e Saude...152. Forattini, O.P. 1962. Entomologia medica vol. I. Faculdade de Higiene e Saude Publica, Sao Paulo, Brazil. 662 pp. Grieco, J.P. 2001. The

Ethical dilemmas experienced by nurses presented in nursing publications Dilemas éticos vivenciados por enfermeros y presentados en publicaciones de enfermería Dilemas éticos vivenciados por enfermeiros apresentados em publicações de enfermagem

Directory of Open Access Journals (Sweden)

Maria Adelane Alves Monteiro

2008-12-01

sentido de contribuir para el cambio de actitud, que implicaría en mejorar la calidad de la práctica profesional.Trata-se de revisão sistemática da literatura, realizada em artigos da área da enfermagem, contidos no banco de dados SCIELO, e que abordaram o tema "ética". Teve como objetivo identificar os dilemas éticos da enfermagem a partir de revisão de literatura em publicações da área, no período de 2002 a 2006. Localizou-se quarenta publicações, das quais foram selecionadas dezessete. A análise dos artigos permitiu a organização das categorias: ética, o sistema de saúde e a prática de enfermagem, ética e o ensino-aprendizagem na enfermagem, ética e o cuidado de enfermagem. Percebeu-se que os autores atribuíram às questões éticas abordagem multidimensional, no entanto, considerou-se, aqui, necessária maior atenção a respeito dos aspectos éticos que permeiam a prática de enfermagem. Ficou clara a necessidade de mais estudos que evidenciem novos dilemas éticos vivenciados por enfermeiros, no sentido de contribuir para mudança de atitude, implicando na qualidade da prática profissional.

Por un sistema de interpretación de los procesos de regionalización e integración andina desde el análisis de políticas publicas

Directory of Open Access Journals (Sweden)

Catalina Toro Pérez

2007-01-01

Full Text Available En Colombia son mas bien recientes, los estudios de investigación sobre el proceso de integración andina y latinoamericana, en tiempos donde, sus relaciones internacionales, oscilan entre una inserción subordinada a los Estados Unidos y su aislamiento frente a los países vecinos, en una solitaria cruzada de por el restablecimiento del mito de la seguridad nacional, la autoridad y el orden en una sociedad que parece, al mismo tiempo, desintegrarse y fragmentarse cada día mas. Sin embargo, mientras el proceso de integración de la Comunidad Andina languidece, un nuevo tipo de regionalización política suramericana, se abre paso, impulsado por movimientos sociales y gobiernos alternativos de Ecuador, Venezuela, Bolivia, Argentina, y Brasil quienes en medio de grandes contradicciones, comienzan a constituir un frente común, contra las políticas de regionalización impuestas por los Estados Unidos, en materia de seguridad, defensa y comercio en el área andina. En un contexto de desintegración andina y de fractura social interna, como abordar la historia de los procesos de integración andina, sus conflictos y sus alternativas de construcción de practicas políticas comunes? Con el fin de aportar a la construcción de un marco de interpretación de los Procesos de Regionalización e Integración Andina, recogemos la contribución reciente de investigadores europeos que desde el campo de la sociología de la acción pública, abordan el análisis de la experiencia comunitaria europea. Luego a partir de diversas aproximaciones a los procesos de Integración andina en particular y latinoamericana en general, arrojamos una primera propuesta de interpretación desde el campo del análisis de las Políticas Publicas.

OPINION PUBLICA, CULTURAS POLITICAS Y DEMOCRACIA

Directory of Open Access Journals (Sweden)

Pedro Santana Rodríguez

1998-01-01

Full Text Available El autor realiza un acercamiento al deber ser de la democracia desde el abordaje de categorías como opinión pública y consenso, elementos indispensables en la construcción de una cultura política.

Transmitted/Founder Viruses Rapidly Escape from CD8+ T Cell Responses in Acute Hepatitis C Virus Infection.

Science.gov (United States)

Bull, Rowena A; Leung, Preston; Gaudieri, Silvana; Deshpande, Pooja; Cameron, Barbara; Walker, Melanie; Chopra, Abha; Lloyd, Andrew R; Luciani, Fabio

2015-05-01

The interaction between hepatitis C virus (HCV) and cellular immune responses during very early infection is critical for disease outcome. To date, the impact of antigen-specific cellular immune responses on the evolution of the viral population establishing infection and on potential escape has not been studied. Understanding these early host-virus dynamics is important for the development of a preventative vaccine. Three subjects who were followed longitudinally from the detection of viremia preseroconversion until disease outcome were analyzed. The evolution of transmitted/founder (T/F) viruses was undertaken using deep sequencing. CD8(+) T cell responses were measured via enzyme-linked immunosorbent spot (ELISpot) assay using HLA class I-restricted T/F epitopes. T/F viruses were rapidly extinguished in all subjects associated with either viral clearance (n = 1) or replacement with viral variants leading to establishment of chronic infection (n = 2). CD8(+) T cell responses against 11 T/F epitopes were detectable by 33 to 44 days postinfection, and 5 of these epitopes had not previously been reported. These responses declined rapidly in those who became chronically infected and were maintained in the subject who cleared infection. Higher-magnitude CD8(+) T cell responses were associated with rapid development of immune escape variants at a rate of up to 0.1 per day. Rapid escape from CD8(+) T cell responses has been quantified for the first time in the early phase of primary HCV infection. These rapid escape dynamics were associated with higher-magnitude CD8(+) T cell responses. These findings raise questions regarding optimal selection of immunogens for HCV vaccine development and suggest that detailed analysis of individual epitopes may be required. A major limitation in our detailed understanding of the role of immune response in HCV clearance has been the lack of data on very early primary infection when the transmitted viral variants successfully establish

Long-Term Effects of Targeted Killings by Unmanned Aerial Vehicles

Science.gov (United States)

2015-04-03

The opinions and conclusions expressed herein are those of the student author, and do not necessarily represent the views of the U.S. Army Command and...Tullius Cicero, “Book III,” in De Re Publica [Concerning the ’Republic’ or ’Commonwealth’], trans. Francis Barham (Mohrsville, PA: Kings Academy, 2011...under “Fragments,” accessed January 22, 2015, http://www.kingsacademy.com/mhodges/08_Classics- Library/hellenist-roman/cicero/de-re- publica /de-re

Brain cortical organization in entrepreneurs during a visual Stroop decision task

Directory of Open Access Journals (Sweden)

Ortiz-Terán E

2013-11-01

Full Text Available Elena Ortiz-Terán,1,4 Agustín Turrero,2 Juan M Santos,3 Peter T Bryant,1 Tomás Ortiz4 1IE Business School, 2Department of Statistics, Universidad Complutense, Madrid, Spain; 3Fundación J Robert Cade and Department of Psychiatry, Universidad Católica de Córdoba, Córdoba, Argentina; 4Department of Psychiatry, Universidad Complutense, Madrid, Spain Abstract: Decision-making in entrepreneurs is a key aspect of their skills, but much about these processes remains unexplained. During a Stroop task, concomitant N200, P300, and N450 event-related potentials were measured in 25 founder entrepreneurs and in age-matched and gender-matched nonfounders/nonentrepreneurs (NFNE. Reaction times were shorter among founder entrepreneurs. The N200 was shorter and N450 larger in founder entrepreneurs. The personalities of both groups were measured using the Temperament and Character Inventory-Revised. Founder entrepreneurs scored significantly higher in novelty-seeking and self-directedness dimensions, as well as in exploratory excitability, impulsiveness, optimism, eagerness, and responsibility subdimensions. Possible interactions among candidate variables to differentiate between founder entrepreneurs versus NFNE were also addressed, and the model including impulsivity, N450 latency, and impulsivity*N450 interaction came up as the best model for discrimination between founder entrepreneurs and NFNE. A shorter N200, mostly associated with bilateral supplementary motor area activation, revealed a faster capability to make decisions when information was noncongruent or blurred. However, the larger N450 revealed a more intense post-evaluation cognitive process happening in founder entrepreneurs and was accompanied by a greater activation of anterior frontal regions. The whole decision-making process consumed more time and resources in founder entrepreneurs, even if its closure was faster. Attention, memory, and alertness, among other factors, have been invoked

United Kingdom Shadow Secretary of State for Universities and Skills David Willetts MP (centre) in front of the CMS detector with (from left to right) A. Barr, Partner and Founder, Matterhorn Investment Management LLP P. Bate, S. Harper, M. Willetts, T. Virdee, J. Ellis, CMS Spokesperson G. Tonelli, CMS Technical Coordinator A. Ball and (front) Partner, Caravel Capital H. Hsueh and P. Wells. Monday 4th January 2010

CERN Multimedia

Maximilien Brice; Point 5

2010-01-01

United Kingdom Shadow Secretary of State for Universities and Skills David Willetts MP (centre) in front of the CMS detector with (from left to right) A. Barr, Partner and Founder, Matterhorn Investment Management LLP P. Bate, S. Harper, M. Willetts, T. Virdee, J. Ellis, CMS Spokesperson G. Tonelli, CMS Technical Coordinator A. Ball and (front) Partner, Caravel Capital H. Hsueh and P. Wells. Monday 4th January 2010

The Influence of Financial 'Skin in the Game' on New Venture Creation

DEFF Research Database (Denmark)

Frid, Casey J.; Wyman, David M.; Gartner, William B.

2015-01-01

A common theme in entrepreneurship research is that the founder must be committed inorder for a new venture to succeed. Although investments of time and sweat equity can indicatecommitment, external stakeholders may prefer founders who have made a significant, personalfinancial stake in their nas......A common theme in entrepreneurship research is that the founder must be committed inorder for a new venture to succeed. Although investments of time and sweat equity can indicatecommitment, external stakeholders may prefer founders who have made a significant, personalfinancial stake...... in their nascent ventures. This personal financial commitment is known as “skinin the game.” Founders that invest more of their own money into their ventures signal greater commitment to potential business partners, suppliers, and resource providers.This studyexamines the amount of personal funds invested by 1...

Influências do "Projeto de Ensino Flora Fanerogâmica do Estado de São Paulo" na formação dos professores participantes em uma escola da cidade de Campinas

OpenAIRE

Lilian Pereira Cruz

2010-01-01

Resumo: O Projeto "Flora Fanerogamica do Estado de Sao Paulo" (FFESP) teve inicio em 1993, com o objetivo de estudar a vegetacao paulista. Em 1997, foi apresentado aos professores de duas escolas publicas de Ensino Fundamental: uma de Campinas e outra de Santos, e duas escolas, tambem publicas, de Ensino Medio: uma de Sao Carlos e outra de Sao Paulo. Em Campinas, o projeto foi desenvolvido com a participacao de professores das disciplinas de Ciencias, Portugues, Artes, Historia e Geografia em...

Sobre discurso feminista em publicações: a política do Grupo Transas do Corpo About feminist discourse in publications: Grupo Transas do Corpo's politics

Directory of Open Access Journals (Sweden)

Joana Plaza Pinto

2004-12-01

Full Text Available Uma sociedade não produz uma única forma de ver a realidade. Dividida pelos interesses antagônicos dos diferentes grupos, uma sociedade produz discursos contrários entre si. Mas há alguns que predominam sobre seus contrários numa dada época, refletindo os interesses de grupos dominantes: os discursos hegemônicos. As contrapartes antagônicas desses discursos dominantes são fortemente submetidas a formas de controle e conjuradas para se passarem por enfraquecidas. Cientes desse jogo discursivo de poder, os discursos feministas proliferam sua discussão sobre a problemática de gênero, defendendo uma sociedade plural, justa e solidária, sem contudo se deixar classificar dentro de alguma tipologia normatizadora. O Grupo Transas do Corpo, ONG feminista brasileira, busca tornar visível cada vez mais a diversidade discursiva feminista e promover a voz das mulheres no campo de discurso público. Para isso, identificou a necessidade de criar espaços de produção de textos de mulheres, de forma a criar e fortalecer a capacidade de letramento das mulheres no contexto das tecnologias de escrita contemporâneas. Para atender a esses objetivos, o Transas elaborou uma política de publicações.A society doesn't yield a only way to see reality. Divided between antagonistic interests of unequal groups, a society yield discourses in contrast and opposites. However there are some discourses that surpass yours antagonistic in your age, reproducing governing groups interests: the hegemoniacal groups. The antagonistic opponent of these governing groups are strongly submit to regulations and render void of power. Aware of these discoursive game of power, feminist discourse proliferate yours ideas about gender trouble, supporting a plural, fair and reciprocal society, although it don't go in on a standard interpretation of discourses types. Transas do Corpo Group, Brazilian feminist NGO, try to make apparent more and more the unlikeness of feminist

Deep genetic divergences among Indo-Pacific populations of the coral reef sponge Leucetta chagosensis (Leucettidae): founder effects, vicariance, or both?

Science.gov (United States)

Wörheide, Gert; Epp, Laura S; Macis, Luciana

2008-01-26

An increasing number of studies demonstrate that genetic differentiation and speciation in the sea occur over much smaller spatial scales than previously appreciated given the wide distribution range of many morphologically defined coral reef invertebrate species and the presumed dispersal-enhancing qualities of ocean currents. However, knowledge about the processes that lead to population divergence and speciation is often lacking despite being essential for the understanding, conservation, and management of marine biodiversity. Sponges, a highly diverse, ecologically and economically important reef-invertebrate taxon, exhibit spatial trends in the Indo-West Pacific that are not universally reflected in other marine phyla. So far, however, processes generating those unexpected patterns are not understood. We unraveled the phylogeographic structure of the widespread Indo-Pacific coral reef sponge Leucetta chagosensis across its known geographic range using two nuclear markers: the rDNA internal transcribed spacers (ITS 1&2) and a fragment of the 28S gene, as well as the second intron of the ATP synthetase beta subunit-gene (ATPSb-iII). This enabled the detection of several deeply divergent clades congruent over both loci, one containing specimens from the Indian Ocean (Red Sea and Maldives), another one from the Philippines, and two other large and substructured NW Pacific and SW Pacific clades with an area of overlap in the Great Barrier Reef/Coral Sea. Reciprocally monophyletic populations were observed from the Philippines, Red Sea, Maldives, Japan, Samoa, and Polynesia, demonstrating long-standing isolation. Populations along the South Equatorial Current in the south-western Pacific showed isolation-by-distance effects. Overall, the results pointed towards stepping-stone dispersal with some putative long-distance exchange, consistent with expectations from low dispersal capabilities. We argue that both founder and vicariance events during the late Pliocene and

Pontos críticos na produção científica de enfermagem - os¹ trabalhos submetidos à REBEn

Directory of Open Access Journals (Sweden)

Joel Rolim Maneia

2002-02-01

Full Text Available Estudo exploratório descritivo que objetivou detectar pontos críticos de manuscritos submetidos à avaliação para publicação na Revista Brasileira de Enfermagem. A coleta de dados se deu a partir de instrumentos de avaliação utilizados pelo Conselho Editorial da Revista Brasileira de Enfermagem, dos quais estudou-se 32 pareceres favoráveis à publicação, correspondentes a 50% dos textos publicados em um volume da revista. Os resultados demonstram que a totalidade dos textos aprovados para divulgação apresentavam deficiência e necessidade de correções, em torno das quais foi possível apresentar requisitos e orientações que auxiliam os autores no encaminhamento de suas produções para periódicos com sistema de revisão por pares. Ainda aparece como uma questão importante o desconhecimento por parte dos autores das normas de publicação do periódico.

Bibliographie

OpenAIRE

2014-01-01

Alabarces Pablo, Crónicas del aguante, futbol, violencia y política, Buenos Aires, capital intelectual, 2004. Alonso Guillermo, « La reforma del seguro social argentino », in Viviane Brachet-Marquez Salud publica y regimenes de pensiones en la era neo-liberal, Mexico, El Colegio de Mexico, 2007, p. 45-101. Alonso Guillermo, La reforma del sistema de pensiones argentino, in Viviane Brachet-Marquez Salud publica y regimenes de pensiones en la era neo-liberal, Mexico, El Colegio de Mexico, 2007,...

Founder effect and estimation of the age of the c.892C>T (p.Arg298Cys) mutation in LMNA associated to Charcot-Marie-Tooth subtype CMT2B1 in families from North Western Africa.

Science.gov (United States)

Hamadouche, T; Poitelon, Y; Genin, E; Chaouch, M; Tazir, M; Kassouri, N; Nouioua, S; Chaouch, A; Boccaccio, I; Benhassine, T; De Sandre-Giovannoli, A; Grid, D; Lévy, N; Delague, V

2008-09-01

CMT2B1, an axonal subtype (MIM 605588) of the Charcot-Marie-Tooth disease, is an autosomal recessive motor and sensory neuropathy characterized by progressive muscular and sensory loss in the distal extremities with chronic distal weakness. The genetic defect associated with the disease is, to date, a unique homozygous missense mutation, p.Arg298Cys (c.892C>T), in the LMNA gene. So far, this mutation has only been found in affected individuals originating from a restricted region of North Western Africa (northwest of Algeria and east of Morocco), strongly suggesting a founder effect. In order to address this hypothesis, genotyping of both STRs and intragenic SNPs was performed at the LMNA locus, at chromosome 1q21.2-q21.3, in 42 individuals affected with CMT2B1 from 25 Algerian families. Our results indicate that the affected individuals share a common ancestral haplotype in a region of about 1.0 Mb (1 cM) and that the most recent common ancestor would have lived about 800-900 years ago (95% confidence interval: 550 to 1300 years).

Editorial

Directory of Open Access Journals (Sweden)

Maria de Jesus Fonseca

2016-02-01

Full Text Available Celebra-se este ano o 15º aniversário de Millenium. A revista, enquanto publicação periódica do Instituto Politécnico de Viseu (IPV, lança o seu 1º número em Fevereiro de 1996 e, desde então até ao presente, tem cumprido com aquela que tem sido a sua periodicidade ao longo dos anos. Esta regularidade e continuidade editoriais que a revista tem conseguido manter ao longo destes 15 anos não é coisa de pouca monta, como bem o sabem os editores de publicações periódicas. Mas é essa regularidade que mantém viva uma publicação deste tipo, dando-lhe consistência e conferindo-lhe credibilidade. Assim, a publicação dos seus sucessivos números, de forma contínua e ininterrupta e em tempo oportuno, tem dado corpo e configurado a identidade de Millenium, assegurando-lhe a fidelidade e a confiança dos seus leitores habituais, garantindo-lhe um espaço próprio e permitindo o seu crescimento junto do público que a procura. Para isso muito contribuiu e continua a contribuir a sua disponibilização on-line em acesso livre, iniciada em 1997, e consumada em 1998 com a colocação on-line da versão integral e completa de cada número da revista.

Shaka Zulu’s Linkage of Strategy and Tactics: An Early Form of Operational Art?

Science.gov (United States)

2014-05-22

Senzangakhona Lineage ........................................................................... 7 Figure 2: Portrait of King Shaka, Founder of the Zulu ...of the Founder of the Zulu Nation (London: Penguin Books, 1955), 65. 13 impi-ebomvu – total war. But treat generously those who submit without war... Founder of the Zulu Nation, 59. 60Ibid., 63. 22 were less than a third of Zwide’s. Despite Shaka’s plea with Dingiswayo to kill Zwide, Dingiswayo

Avaliação na acessibilidade das ferramentas de geração automáticas de blogs

OpenAIRE

Pernambuco, Teresa Rachel de Arruda

2013-01-01

Nesta dissertação foram avaliados sistemas para publicação de blogs, no que diz respeito à acessibilidade web, em um estudo direcionado para deficientes visuais. A partir desse estudo foi possível levantar alguns problemas e percebe-se que pessoas com deficiências têm muita dificuldade para se incluir na sociedade e os sistemas para publicação de blogs podem ajudar nesta inclusão. Um estudo de caso foi desenvolvido para descobrir erros de acessibilidade nos sistemas de publi...

Cultura em Comentário: uma revista de cultura e resistência (1960 - 1973)

OpenAIRE

Taciana Wiazovski

2011-01-01

Este estudo reconstitui a trajetória e a contribuição intelectual de Comentário (1960-1973), revista financiada pelo American Jewish Committee (AJC) que seguiu o modelo da americana Commentary criada quinze anos antes. A publicação reuniu proeminentes nomes da cultura nacional e internacional da década de 1960. Procuramos pelas origens da revista nos Estados Unidos por meio de sua relação com a empreitada cultural norte-americana durante a Guerra Fria, considerando que tal publicação se dizia...

A Gazeta dos Caminhos de Ferro e a Promoção do Turismo em Portugal (1888-1940).

OpenAIRE

Figueiredo Ribeiro, Elói de

2009-01-01

Tendo como objecto de estudo a Gazeta dos Caminhos de Ferro pretende-se fazer uma abordagem ao desenvolvimento do turismo em Portugal no período que decorreu entre 1888 e 1940. O levantamento dos vários artigos publicados na Gazeta e as iniciativas dos seus editores para incentivar as viagens turísticas permitem perceber o papel relevante que esta publicação teve no desenvolvimento do turismo em Portugal. Sendo uma publicação dedicada ao caminho-de-ferro a Gazeta traduz a importância que este...

Resultados do Grupo de Trabalho de Tecnologias Avançadas IDE do Projecto OTALEX C

OpenAIRE

Vivas, Pedro; Álvarez, Rafael; Mateus, Júlio; Pavo, Marcos; Rubio, J.M.; González, Julián; Soriano, Marcos; Caballero, Carmen; Aparício, Alberto; Batista, T.; Carriço, Cristina; Cabezas, José; Fernández, Luis; Jiménez, Alberto; Gamero, Ulises

2013-01-01

Apresentam-se os resultado do Grupo de Trabalho de Tecnologias Avançadas IDE do projeto OTALEX-C, sendo estes: a geração de dados interligados de elementos geográficos do território OTALEX-C para a publicação de uma Web Semântica, e a captura e publicação de dados ambientais através de serviços padronizados de registo de observações com recurso a sensores, aplicando a standard SOS definida pela OGC. POCTEP 2007-2013

Deep genetic divergences among Indo-Pacific populations of the coral reef sponge Leucetta chagosensis (Leucettidae: Founder effects, vicariance, or both?

Directory of Open Access Journals (Sweden)

Epp Laura S

2008-01-01

founder and vicariance events during the late Pliocene and Pleistocene were responsible to varying degrees for generating the deep phylogeographic structure. This structure was perpetuated largely as a result of the life history of L. chagosensis, resulting in high levels of regional isolation. Reciprocally monophyletic populations constitute putative sibling (cryptic species, while population para- and polyphyly may indicate incipient speciation processes. The genetic diversity and biodiversity of tropical Indo-Pacific sponges appears to be substantially underestimated since the high level of genetic divergence is not necessarily manifested at the morphological level.

Public illumination manual; Manual de iluminacao publica

Energy Technology Data Exchange (ETDEWEB)

NONE

1992-12-31

This work aims to guide in the correct choice and usage of the adequate public illumination equipment. It also aims to help the public authorities in terms of the best economical and technical choice, as well as the adequate maintenance of the equipment in order to obtain the most efficiency and safety with minimum costs 22 figs., 11 tabs.

Biblioteca Publica en Huntington Beach (EE.UU.

Directory of Open Access Journals (Sweden)

Historico, Dion

1977-07-01

Full Text Available The first stage, which is the only one completed up to the present time, consists of a more extensive architectural complex conceived for housing different cultural functions besides the library: plastic arts, cinematography, scientific and informative activities, etc. The building is organized in two main floors in a rectangular shape, and in several mezzanines, reading rooms, book deposits, projection areas, music and painting departments and technical administration and maintenance offices, occupying a total of approximately 4,400 m2. The architectural design denotes the intention of integration in the treatment of the inside spaces, by the suppression of separate compartments, organizing the necessary distinction of functions in the reading rooms, by means of differences of floor levels and with the use of adequate decorative elements. In the same manner, the outside walls have been substituted by complete glass surfaces which allow full incorporation of the natural surroundings in the architecture.Constituye la primera fase, única realizada hasta el presente, de un complejo arquitectónico más amplio concebido para albergar distintas funciones culturales además de biblioteca: artes plásticas, cinematografía, actividades científicas e informativas, etc. El edificio se organiza en dos plantas principales, de forma rectangular, y en diversas entreplantas, salas de lectura, depósitos de libros, locales de proyección, departamentos de música y pintura, y oficinas técnicas de administración y mantenimiento, ocupando un total aproximado de 4.400 m2. El planteamiento arquitectónico denota un propósito integrador en el tratamiento de los espacios interiores, por la supresión de las compartimentaciones de fábrica, organizándose la necesaria distinción de ambientes en las salas de lectura, mediante diferencias de nivel del suelo y con el empleo de adecuados elementos decorativos. Del mismo modo, los muros de fachada se han sustituido por paramentos íntegramente acristalados, que permiten una plena incorporación del entorno natural en la arquitectura.

Public illumination manual; Manual de iluminacao publica

Energy Technology Data Exchange (ETDEWEB)

NONE

1993-12-31

This work aims to guide in the correct choice and usage of the adequate public illumination equipment. It also aims to help the public authorities in terms of the best economical and technical choice, as well as the adequate maintenance of the equipment in order to obtain the most efficiency and safety with minimum costs 22 figs., 11 tabs.

QUANTIFICAÇÃO DE TECNOLOGIAS EM GASEIFICAÇÃO ATRAVÉS DA ANÁLISE DOS PEDIDOS DE PATENTES E ARTIGOS LITERÁRIOS

Directory of Open Access Journals (Sweden)

Mikele Cândida Sousa Sant'Anna

2013-03-01

Full Text Available A gaseificação é o processo termoquímico que converte insumos sólidos, líquidos ou gaosos em gases com características basicamente combustíveis, através de sua oxidação parcial a temperaturas intermediárias. Para este processo diversos tipos de metodologias e equipamentos foram desenvolvidos nos ultimos anos, tendo em vista o destaque que as energias alternativas ganharam para as próximas décadas, em substituição aos combustíveis fosseis. Para a realização da busca de patentes utilizou-se a base da World Intellectual Property Organization (WIPO, do Banco de dados do Instituto Nacional de Propriedade Industrial (INPI e do European Patent Office (Espacenet. Para o monitoramento de publicações literárias utilizou-se as coleções indexadas do portal dos periódicos da CAPES e as bases indexadas do Scopus e Scielo.  Como resultados, a base de patentes que apresentou  maiores percentuais de registros foi Espacenet, seguido por WIPO e por ultimo INPI. O maior quantitativo de publicações literárias encontram-se nos periódicos do Scopus, seguida das bases CAPES e Scielo. As patentes foram apresentadas por ano de depósito, classificação internacional e país de depósito. Os artigos foram classificados pelo numero de publicações por base indexadas, idiomas de publicação, principais países e periódicos.

O ESTUDO DO CETICISMO NAS PESQUISAS DE MARKETING VERDE: UMA REVISÃO DE PUBLICAÇÕES BRASILEIRAS

OpenAIRE

Abilio Peixoto Diógenes; Minelle E. Silva

2017-01-01

RESUMO A presente pesquisa tem como foco entender como está sendo abordada a temática ceticismo com relação ao marketing verde nos principais periódicos e eventos brasileiros. Para tanto, a metodologia baseia-se em uma revisão sistemática da literatura nos principais veículos de publicação do Brasil, no período de 2013 a 2016, visando identificar a abordagem da temática. Na pesquisa os dados foram analisados conforme os seguintes critérios: autoria dos artigos e anos de publicação; objetiv...

Ethical abuses in the authorship of scientific papers

OpenAIRE

Carneiro,Marco Antonio A.; Cangussú,Silvia D.; Fernandes,G. Wilson

2007-01-01

Imposturas na Autoria de Artigos Científicos. Problemas relacionados a determinação de autoria de trabalhos científicos são freqüentes. Estes problemas vêm se agravando em decorrência da supervalorização do número de publicações no mundo acadêmico, uma vez que, a publicação de artigos científicos tornou-se uma referência de sucesso em um campo com poucas oportunidades de trabalho. Este artigo revê os abusos na autoria de artigos científicos. Diferentes exemplos são citados dos problemas mais ...

Estado de conocimiento sobre la integración de sistemas de gestión a partir del análisis bibliométrico de artículos publicados en revistas JCR

OpenAIRE

Camps Pons, Francisca

2016-01-01

La implantación de sistemas de gestión integrados (SIG) puede proporcionar muchos beneficios a las organizaciones, pero, aún hoy en día, son desconocidos por muchas empresas. El objetivo principal de este trabajo es realizar un meta análisis de las publicaciones científicas aparecidas en la base de datos JRC referidas a la integración de sistemas de gestión, para, recopilar información sobre qué temática se publica, dónde se publica y de qué forma, para tener conocimiento sobre qué y cómo ...

Uma produção de conhecimento no período de 1995 a 2010: livros de ensino religioso = A production of knowledge in the period 1995 to 2010: books religious education

Directory of Open Access Journals (Sweden)

Dissenha, Isabel Cristina Piccinelli

2011-01-01

Porém pode-se perceber que temos a carência de publicação de obras que abordem temas referentes à formação de professores, sistematização dos aspectos pedagógicos e metodológicos, assim como de novas proposições de estrutura curricular subsidiada pela Ciência da Religião. Outra temática não explorada é sobre os livros didáticos e as novas tecnologias para apoiar a ação docente e discente, o que exigirá novas perspectivas de publicação

Network Science Center Research Team’s Visit to Kampala, Uganda

Science.gov (United States)

2013-07-01

the intersection of open data, human rights, and African development. Jon is the founder or co- founder of several organizations and initiatives...drove across Kampala to meet with Teddy Ruge, a co- founder of Hive CoLab and a noted Ugandan Social Entrepreneur, and Brian Ndyaguma, the operations...www.netscience.usma.edu 845.938.0804 At Outbox, we were hosted by Richard Zulu , the general manager. Outbox was founded in 2012 and is the newest business incubator

MACHIAVELLI DÜŞÜNCESİNDE CUMHURİYETÇİ ÖZGÜRLÜK VE KURUCU LİDER İMGESİ

OpenAIRE

ÖZTÜRK, Armağan

2014-01-01

In this article, the thoughts of Machiavelli on ethics and politics will be addressed in detail and the republican freedom and founder leader themes will be opened to discussion with regards to the mentioned thought. The main problematic on the base of the discussion is characterized by the issues that what Machiavelli expects from the prince who is the founder of the state; and in this respect whether there is a tension between the founder leader and republican sensibility. Of course, such a...

Glossary

Science.gov (United States)

... Huntington disease in the Lake Maracaibo region of Venezuela. Related term: founder variant founder variant A pathogenic ... Support Center External link. Please review our privacy policy . NLM NIH DHHS USA.gov National Center for ...

The founders of the ININ

International Nuclear Information System (INIS)

Bulbulian, S.

2006-01-01

The Mexican government sent the constituent law of the National Commission of Nuclear Energy (CNEN) at December 31, 1955. This classification enters in validity the January 1, 1956. However the Commission began to work in the last months 1956. This institution development two main activities: 1. A program of training on techniques with radioisotopes and nuclear instrumentation and 2. The creation of specialized programs and laboratories. Very important persons in the CNEN were the members of the Commission, the Dr. Manuel Sandoval Vallarta, the Dr. Nabor Carrillo Flores and the Atty. Jose Maria Ortiz Tirado, President of this institution. (Author)

Analysis of TGM1, ALOX12B, ALOXE3, NIPAL4 and CYP4F22 in autosomal recessive congenital ichthyosis from Galicia (NW Spain): evidence of founder effects.

Science.gov (United States)

Rodríguez-Pazos, L; Ginarte, M; Fachal, L; Toribio, J; Carracedo, A; Vega, A

2011-10-01

  Mutations in six genes have been identified in autosomal recessive congenital ichthyosis (ARCI). To date, few studies have analysed the spectrum of these mutations in specific populations. We have studied the characteristics of patients with ARCI in Galicia (NW Spain). Methods  We recruited patients by contacting all dermatology departments of Galicia and the Spanish patient organization for ichthyosis. TGM1, ALOX12B, ALOXE3, NIPAL4 and CYP4F22 were analysed in the patients and their relatives. We identified 23 patients with ARCI and estimated a prevalence of 1 : 122 000. Twenty of the patients were studied. Seventeen of them were clinically categorized as having lamellar ichthyosis (LI) and three as having congenital ichthyosiform erythroderma (CIE). TGM1 and ALOXE3 mutations were identified in 12/16 (75%) probands whereas no ALOX12B, NIPAL4 and CYP4F22 mutations were found. TGM1 mutations were found in 11/13 (85%) of LI probands. ALOXE3 mutations were identified in a single patient with CIE. Remarkably, mutations p.Arg760X, p.Asp408ValfsX21 and c.984+1G>A of TGM1 were present in six, four and two families, accounting for 41%, 23% and 14% of all TGM1 mutant alleles, respectively. The high percentage of patients with the same TGM1 mutations, together with the high number of homozygous probands (64%), indicates the existence of a strong founder effect in our population. © 2011 The Authors. BJD © 2011 British Association of Dermatologists 2011.

Panorama brasileiro e espanhol sobre teses de doutorado na área das altas habilidades/superdotação

Directory of Open Access Journals (Sweden)

Ketilin Mayra Pedro

2015-12-01

Full Text Available No Brasil a área das Altas Habilidades/Superdotação (AH/SD foi contemplada inicialmente na LDB 5692/71 (BRASIL, 1971, enquanto na Espanha o marco inicial se dá a partir do Real Decreto 696/1995 (ESPANHA, 1995, garantindo a esse alunado ao direito a identificação e atendimento. Visando contribuir com as pesquisas desta área, elaboramos o atual panorama brasileiro e espanhol em relação as teses de doutorado sobre AH/SD. Para a realização desta investigação consultamos a Biblioteca Digital Brasileira de Teses e Dissertações e a Base de datos de Tesis Doctorales. Foram localizadas um total de 70 teses, sendo 20 brasileiras e 50 espanholas. Com base na análise do título, do resumo e das palavras-chaves, elencamos categorias temáticas, sendo que foram predominantes: Identidade, Identificação e Avaliação. A primeira tese brasileira defendida data de 1989, enquanto que na Espanha a primeira tese é de 1990. Em relação ao local de publicação, no Brasil percebemos que há uma predominância em relação as universidades federais, enquanto na Espanha, a Universidade Complutense de Madrid destaca-se em número de publicações. Percebemos que embora o número de publicações tenha aumentado progressivamente, esse ainda figura-se como incipiente frente ao número de publicações de outras áreas e a demanda de trabalho que esses estudantes requerem.

Jobs

DEFF Research Database (Denmark)

Schubart, Rikke

2013-01-01

Review of the movie Jobs (Joshua Michael Stern, 2013), a drama about Steve Jobs, the founder of Apple.......Review of the movie Jobs (Joshua Michael Stern, 2013), a drama about Steve Jobs, the founder of Apple....

Sketching the Global Social Media Landscape = Küresel sosyal medya alanının Avrupa ve Hollanda'ya odaklanarak Taslaklandırılması

OpenAIRE

Reijgersberg, Maarten

2016-01-01

Maarten Reijgersberg is the founder of and social media architect at RauwCC, social media the Rotterdam way. RauwCC is ranked as the number one social agency in The Netherlands by Emerce 100/2015. Maarten is also the founder of Social Media Week Rotterdam, the largest annual conference on social media and innovation in the Benelux region. Besides his work at RauwCC and Social Media Week Rotterdam, Maarten is the founder of Social Media Signage, the window to your online activity. Social Media...

Jornalismo, gêneros e diversidade cultural nas revistas brasileiras

Directory of Open Access Journals (Sweden)

Ana Regina Rêgo

Full Text Available Este artigo apresenta os resultados de uma pesquisa realizada em três publicações jornalísticas brasileiras de caráter cultural, a saber: Cult, Bravo e Brasileiros, que foram analisadas com o objetivo de identificar a visibilidade das manifestações culturais em suas páginas, por meio do mapeamento das matérias veiculadas. Em outro prisma, o intuito foi mapear os gêneros jornalísticos mais trabalhados na veiculação das matérias referentes à cultura, com vistas a identificar o grau de importância dado ao temas culturais retratados nas publicações, assim como, verificar as tendências no texto do Jornalismo Cultural. A metodologia utilizada no primeiro caso foi o diagnóstico simples e no segundo caso foi análise de conteúdo por emparelhamento. Ao final conclui-se que embora o Jornalismo Cultural brasileiro esteja se abrindo para divulgar a diversidade do país, ainda permanece uma predominância destacável dos eventos do sudeste entre os temas pautados pelas publicações citadas.

Pago y sostenibilidad de la deuda pública: ejercicios de simulación para algunas economías latino americanas

Directory of Open Access Journals (Sweden)

Andrés Ramírez Hassan

2006-10-01

Full Text Available Se desarrolla el marco teorico implicito en la restricción presupuestaria intertemporal del gobierno. A partir de este se realizan una serie de simulaciones sobre el problema de sostenibilidad de la deuda publica, y los sacrificios fiscales necesarios para juzgar el actual nivel de endeudamiento sostenible. Se observa que Colombia ubicada en el contexto analizado se encuentra en un lugar intermedio con respecto al esfuerzo fiscal necesario para sostener la deuda publica, concretamente se requiere un superavit primario promedio equivalente al 2.51% del PIB. Esta magnitud es inferior a la requerida por Argentina y Brasil, pero superior a los requerimientos de Venezuela, Chile y Mexico

O MERCADO ACADÊMICO CONTÁBIL BRASILEIRO: UMA ANÁLISE DO CENÁRIO A PARTIR DAS PRÁTICAS DE PUBLICAÇÃO E AVALIAÇÃO POR PARES

OpenAIRE

Espejo, Márcia Maria Santos Bortolocci; Azavedo, Sayuri Unoki; Trombelli, Renata Oliveira; Voese, Simone Bernardes

2013-01-01

O estudo tem como objetivo analisar o cenário acadêmico contábil brasileiro no que se refere às práticas de publicação e avaliação por pares, refletindo especificamente sobre como os eventos podem contribuir efetivamente para a eficiência do processo de qualificação da produção científica da área de Contabilidade, por meio da elaboração de uma proposta para a comunidade acadêmica. Esta pesquisa possui abordagem quantitativa e emerge a partir de três construtos: a conversão das publicações, a ...

O TEMA “CUSTOS” EM PERIÓDICOS DA ENGENHARIA DE PRODUÇÃO: UMA ANÁLISE BIBLIOMÉTRICA E PERSPECTIVAS FUTURAS

OpenAIRE

Alvarenga, Tiago Henrique de Paula; Sartori, Simone; Assumpção, Jairo José; Campos, Lucila Maria Souza

2015-01-01

O objetivo desse artigo é realizar um mapeamento das publicações sobre o tema custos na engenharia de produção e, como consequência, identificar um portfólio bibliográfico das publicações na área. Para atender ao objetivo, fez-se uma análise bibliométrica nos dois principais periódicos brasileiros especializados na área de engenharia de produção (Produção – ISSN 0103-6513 e Gestão & Produção – ISSN 0104-530X). Após a busca, foram selecionados 43 artigos relevantes e 540 artigos de referências...

Homossexualidades de papel: cenas da imprensa homoerótica no Brasil (1963-2015)

OpenAIRE

Arias Neto, José Miguel; Pessoa Do Amaral, Muriel Emídio

2016-01-01

Pelo método histórico, esse artigo discorre sobre a imprensa homoerótica brasileira apontando como esse segmento de imprensa estabeleceu um diálogo com as manifestações culturais, os modos de representação das homossexualidades e signos homoeróticos. Para isso, a pesquisa analisa O Snob, primeira publicação homoerótica brasileira, da década de 1960; o jornal Lampião da Esquina, que circulou de 1978 a 1982; a revista Junior, que se manteve de 2007 a 2013 e a revista Nin, a única publicação em ...

Richard Francis Burton e a inserÃÃo do kama-sutras como um manual sexual entre os vitorianos (Inglaterra, 1883)

OpenAIRE

Felipe Salvador Weissheimer

2014-01-01

Dentre os vÃrios âKama-sutrasâ difundidos no mercado, a versÃo clÃssica foi escrita por Vatsyayana (sÃculo I-IV, aproximadamente) e publicada na Inglaterra em 1883 pela Sociedade Hindu Kama-Shastra. Richard Francis Burton foi o membro de maior importÃncia na Sociedade Hindu Kama-Shastra, pois, alÃm de fomentar a publicaÃÃo, auxiliou na traduÃÃo, editou e enunciou vÃrios comentÃrios ao longo da obra. Em seus comentÃrios, percebemos que o projeto da traduÃÃo e publicaÃÃo do Kama-sutras visava e...

Cultura de integridade em pesquisa: somos agentes promotores

OpenAIRE

Ana Paula Abdon

2015-01-01

A Revista Brasileira em Promoção da Saúde (Brazilian Journal in Health Promotion), movida pela necessidade de uma cultura que estimule a integridade em pesquisa, quer enfatizar sua preocupação, não apenas com o conteúdo de suas publicações, mas também com os aspectos éticos que envolvem a submissão e a publicação dos manuscritos. Com isso, pretende levantar a discussão sobre boas práticas em pesquisa científica, ressaltando a importância de que este reforço ocorra desde os primeiros estágios ...

Educação a distância e diversidade no ensino superior

OpenAIRE

Aires, Luísa; Moura, Ana Pinto de; Seabra, Filipa; Moreira, J. António

2014-01-01

Os textos desta publicação refletem, de forma aprofundada, o pensamento dos autores sobre Educação a Distância e Inovação Pedagógica e, em particular, sobre o papel das metodologias, interações e dos recursos educacionais na inclusão e participação da população adulta no Ensino Superior. Estas reflexões foram, inicialmente, apresentadas no Seminário Educação a Distância e Diversidade no Ensino Superior, realizado no Porto, em julho de 2014 e, posteriormente, aprofundadas para publicação no pr...

O nascimento da Revista Brasileira de Criminalística

OpenAIRE

Ângela Tonietto; Bruno Telles; Charles Albert Andrade; Claudemir Rodrigues Dias Filho; Elvis Medeiros; Juliano de Andrade Gomes; Maria Paula Oliveira Valadares

2011-01-01

Nasce a Revista Brasileira de Criminalística (RBC): uma publicação periódica de um antigo anseio da comunidade de Peritos Criminais em ver a produção científica divulgada em revista especializada genuinamente brasileira. A RBC destina-se à publicação de artigos que contribuam para a promoção, a divulgação e o desenvolvimento científico e tecnológico das ciências forenses, referentes aos resultados de pesquisas, avanços, projetos técnico-científicos e relatos de caso relacionados à criminalíst...

Deconstructing Jaco: genetic heritage of an Afrikaner.

Science.gov (United States)

Greeff, J M

2007-09-01

It is often assumed that Afrikaners stem from a small number of Dutch immigrants. As a result they should be genetically homogeneous, show founder effects and be rather inbred. By disentangling my own South African pedigree, that is on average 12 generations deep, I try to quantify the genetic heritage of an Afrikaner. As much as 6% of my genes have been contributed by slaves from Africa, Madagascar and India, and a woman from China. This figure compares well to other genetic and genealogical estimates. Seventy three percent of my lineages coalesce into common founders, and I am related in excess of 10 times to 20 founder ancestors (30 times to Willem Schalk van der Merwe). Significant founder effects are thus possible. The overrepresentation of certain founder ancestors is in part explained by the fact that they had more children. This is remarkable given that they lived more than 300 years (or 12 generations) ago. DECONSTRUCT, a new program for pedigree analysis, identified 125 common ancestors in my pedigree. However, these common ancestors are so distant from myself, paths of between 16 and 25 steps in length, that my inbreeding coefficient is not unusually high (f approximately 0.0019).

A publicação de dados governamentais abertos: proposta de revisão da classe sobre Previdência Social do Vocabulário Controlado do Governo Eletrônico

Directory of Open Access Journals (Sweden)

Cláudio José Silva Ribeiro

Full Text Available Este trabalho analisa a classe sobre Previdência Social do Vocabulário Controlado do Governo Eletrônico, investigando a publicação de dados governamentais abertos, realizada pela Empresa de Tecnologia e Informações da Previdência Social. Trata-se de um estudo exploratório, com objetivo de propor a revisão da classe sobre Previdência Social no domínio do Governo Eletrônico brasileiro, a fim de ampliar e corrigir a representação da área. O trabalho utiliza como metodologia: (1 pesquisa bibliográfica, para fundamentação teórica; (2 seleção da classe de assunto sobre Previdência Social do Vocabulário Controlado do Governo Eletrônico, como recorte; (3 análise dos pontos relacionados à categorização, linguagem escolhida (natural ou artificial, cobertura dos termos pertencentes ao escopo da classe de assunto estudado e relações apresentadas entre os termos; (4 propostas para revisão da classe estudada. O estudo aponta, nos resultados, falhas estruturais e inconsistências conceituais localizados no vocabulário. Discute a necessidade de se utilizarem vocabulários consistentes para representação dos dados publicados, a fim de torná-los legíveis por máquina e compartilháveis entre aplicações de software. Afirma que se deve investir em vocabulários já existentes para evitar esforços com a criação de outros instrumentos de representação. Julga necessário que outros órgãos públicos, além da Empresa de Tecnologia e Informações da Previdência Social, interessem-se em analisar e propor alterações e atualizações nas classes cuja temática contemple os dados por eles geridos. Conclui que a utilização do Vocabulário Controlado do Governo Eletrônico pode ir além de um mapa para navegação em páginas eletrônicas do setor público brasileiro, constituindo instrumento dinâmico de organização do conhecimento, podendo ser utilizado para diversos fins, de acordo com os interesses de cada usuário.

Government teeters on edge of collapse / Aleksei Gunter

Index Scriptorium Estoniae

Gunter, Aleksei, 1979-

2005-01-01

Valitsuses tekkinud kriisist seoses justiitsministri korruptsiooni vastu võitlemise programmiga. Lisa: Res Publica ja Keskerakond ühinesid Tallinnas. Tabel: Kohtade jagunemine erakondade vahel Riigikogus

Whole genome scan in chickens for quantitative trait loci affecting carcass traits

NARCIS (Netherlands)

Kaam, van J.B.C.H.M.; Groenen, M.A.M.; Bovenhuis, H.; Veenendaal, A.; Vereijken, A.L.J.; Arendonk, van J.A.M.

1999-01-01

An experiment was conducted to enable quantitative trait loci (QTL) mapping for carcass traits. The population consisted of 10 full-sib families originating from a cross between male and female founders chosen from two different outcross broiler lines. Founder animals, parents, offspring, and

Enacted identities in the university spin-off process - bridging an imaginative gap

DEFF Research Database (Denmark)

Hannibal, Martin

2017-01-01

This paper employs a case study to explore the interdependencies between enacted role identities and behavioural logics of eight inventor-founders embedded in university spin-off venturing. The major tendencies in the findings suggest that the inventor-founders enact their academic role identity ...

Indicadores da produção científica e co-autoria: análise do departamento de ciências da informação da UFRGS

Directory of Open Access Journals (Sweden)

Josiane Gonçalves da Costa

2012-01-01

Full Text Available Através da Bibliometria, investigam-se as características de 248 documentos publicados pelos docentes do Departamento de Ciências da Informação da Universidade Federal do Rio Grande do Sul entre 2000 e 2008. O objetivo do estudo foi delinear o perfil de publicação departamental em relação aos seguintes indicadores: tipologia dos documentos, assunto, idioma, ano e local de publicação, redes de colaboração, títulos de periódicos e eventos utilizados como canais de comunicação científica. Os resultados indicam uma tendência à pesquisa colaborativa entre os docentes investigados, seus colegas e alunos da faculdade (74,3%, e revelam que anais de eventos e periódicos nacionais são os canais mais utilizados pelos professores para comunicação científica. Destaca como eventos mais utilizados para publicação o CBBD e INTERCOM e aponta a revista Em Questão (publicação eletrônica da faculdade como principal periódico. Reforça a ideia de que a Ciência da Informação no Brasil ainda é um campo em formação, sem padrões próprios de comportamento em relação à comunicação científica. Conclui que a Bibliometria é um método eficiente para coleta de subsídios à tomada de decisões no âmbito das políticas cientificas e da gestão de bibliotecas, mas requer atenção quanto à interpretação dos resultados.

MINERAÇÃO DE DADOS APLICADA A RELAÇÃO CLIENTES E PAGAMENTOS – ESTUDO BIBLIOMÉTRICO

Directory of Open Access Journals (Sweden)

Alcione Dias Silva

2013-03-01

Full Text Available O KDD (Knowledge Discovery in Database e a Mineração de Dados incluem tarefas e métodos para extração de conhecimento útil, interessante e indispensável na tomada de decisões rápidas nas mais diversas áreas de conhecimento. Esta pesquisa tem como objetivo nortear o leitor na vasta relação de trabalhos que se utilizam desta importante ferramenta e apontar as principais publicações de Mineração de Dados utilizadas na relação clientes e pagamentos, no âmbito público e privado, além de propor chaves de pesquisa que possam contribuir para a obtenção de trabalhos relacionados com objetivo de facilitar as buscas pertinentes a este importante assunto. Quanto à metodologia, foram pesquisadas as publicações relacionadas às técnicas de Mineração de Dados aplicadas a base de dados tributária pertencente a entidades governamentais estendendo-se analogamente aos trabalhos similares na área privada. A base de dados utilizada para este estudo foi a SCOPUS no período de janeiro de 1999 a março de 2012. Dentre os 927 resultados obtidos, tem merecido destaque o setor de pagamentos eletrônicos via cartões de crédito e a rede neural artificial como técnica aplicada com maior sucesso. O idioma mais utilizado para a confecção das publicações foi o inglês. Os resultados apresentados contribuem no sentido de direcionar os autores quanto às áreas mais carentes de trabalhos científicos aplicados a Mineração de Dados, os países e idiomas com maior número de publicações, contribuindo de forma direcionada para o enriquecimento de trabalhos futuros.

Public opinion, public information and public implication in radioactive waste management in the European Union; La opinion publica, informacion publica e implicacion publica en la gestion de residuos radiactivos en la Union Europea

Energy Technology Data Exchange (ETDEWEB)

Taylor, D.; Webster, S.

2004-07-01

The nuclear industry in European must address the issue of the lack of Public acceptance. In particular, the public are very concerned about radioactive waste. It is clear that there is a need to better inform the public about radioactive waste and to consult them as part of the decision-making process concerning the management of these wastes. Existing and proposed new European legislation not only encourage this provision of information and involvement in the decision-making process, but actually require it. The paper examines Public opinion and European legislation in this area and reports on the latest research on societal issues in radioactive waste management carried out under the Community's Euratom Framework Programme. (Author)

Svalilsja, no ne provalilsja / Jevgenija Garanzha

Index Scriptorium Estoniae

Garanža, Jevgenija, 1979-

2005-01-01

Peaminister Juhan Parts viis presidendile valitsuse tagasiastumisavalduse. Res Publica ei pea ennast koalitsiooni lagunemise põhjustajaks. Vt. samas Josef Katsi art. Riigikogu esimehe ja juhatuse valimistest

Finance minister resigns amid fraud probe / Aleksei Gunter

Index Scriptorium Estoniae

Gunter, Aleksei, 1979-

2003-01-01

Rahandusminister Tõnis Paltsi tagasiastumisest. Uus kandidaat rahandusministri ametikohale on Res Publica parlamendifraktsiooni esimees ja rahanduskomisjoni liige Taavi Veskimägi. Kommentaarid Pakterminali juhatuse esimehelt Aadu Luukaselt

Riigikokku pääseb läbi kolme sõela / Marko Suurmägi

Index Scriptorium Estoniae

Suurmägi, Marko, 1975-

2007-01-01

Kui iga erakonna üleriigilise nimekirja järjestus jääb samaks ka pärast valimisi, siis piirkondlik reastatakse pärast tulemuste selgumist saadud häälte arvu järgi ümber. Nii kerkib iga partei kõige rohkem hääli saanud liige esimeseks ja vähim toetust leidnud kandidaat viimaseks. Lisa: Võimalused. Isamaa ja Res Publica Liidu kandidaadi Helir-Valdor Seedri ja Rahvaliidu kandidaadi Jaak Alliku arvamus. Vt. samas lühiinter. valimistel osalevate erakondade esindajate Priit Toobali (Keskerakond), Meelis Atoneni (Reformierakond), Jaak Alliku (Rahvaliit), Helir-Valdor Seedri (Isamaa ja Res Publica Liit), Heiki Järveveeri (Sotsiaaldemokraatlik Erakond), Tanel Tammeti (Erakond Eestimaa Rohelised) ja Valentine Alvrega (Eesti Kristlikud Demokraadid)

Population specific genetic heterogeneity of familial hypercholesterolemia in South Africa.

Science.gov (United States)

Smyth, Natalie; Ramsay, Michèle; Raal, Frederick J

2018-04-01

To describe the prevalence and population-specific genetic heterogeneity of familial hypercholesterolemia in South Africa. This review highlights the paucity of data on familial hypercholesterolemia in South Africa, and the urgent need to uncover the mutation profiles in lipid-associated genes, causing an increase in LDL-cholesterol in the different ethnic groups. Case reports and small studies have shown that familial hypercholesterolemia, although apparently uncommon, is present in black Africans. Local founder effects have led to an increased prevalence of familial hypercholesterolemia in several South African populations: Afrikaner founder mutations (c.681 C>G, c.1285 G>A, c.523 G>A), Ashkenazi founder mutation (c.654_656del) and possible Indian founder mutation (c.2054 C>T). Preliminary data in black Africans with elevated LDL-cholesterol identified a possible common mutation, c.137_142del. The South African multiethnic society and well described founder effects emphasize the need for differential approaches to diagnosis and management of familial hypercholesterolemia. Studies involving larger cohorts and inclusive of different ethnicities are paramount to establishing an accurate prevalence of familial hypercholesterolemia in black Africans, not only in South Africa but in the Sub-Saharan African region. It is clear that the estimated world prevalence of one in 250 cannot be generally applied across African populations.

Editorial

Directory of Open Access Journals (Sweden)

Thaís Zerbini

2018-04-01

Full Text Available Como destacado no número anterior, a rPOT foi contemplada com mais um importante indexador: O DOAJ (Directory of Open Access Journals, diretório de revistas eletrônicas de acesso aberto, mantido pela Lund University Libraries na Suécia, o qual permite o acesso gratuito a revistas científicas e acadêmicas de qualidade. Continuando a política de aprimoramento do processo de editoração científica, a partir do número 3, a rPOT iniciará suas publicações no primeiro dia de cada trimestre. Neste número 2, em especial, iniciaremos com a publicação de um artigo no primeiro dia do trimestre, intitulado “Assédio moral no judiciário: Prevalência e repercussões na saúde dos trabalhadores” e, em algumas semanas, em função do processo de transição do cronograma de publicação, os demais artigos do número estarão disponíveis. Destaco e agradeço o trabalho dos Editores Associados, bem como de nossa Assistente Editorial. Desejamos a todos uma ótima leitura do presente artigo!

RELAÇÕES APOSENTADORIA, FAMÍLIA E SAÚDE DO TRABALHADOR

Directory of Open Access Journals (Sweden)

Débora Aparecida Moura Campos

2017-01-01

Full Text Available Resumo: Ao se aposentar, o indivíduo deixa de desempenhar seu papel de trabalhador “formal”, passando a focalizar o desempenho de um membro mais ativo na família. Este artigo teve por objetivo identificar as inter-relações entre o fenômeno da aposentadoria na família e na saúde do trabalhador, analisando as publicações nacionais, em especial, artigos científicos, no período de 2013 a 2015, a partir dos descritores “aposentadoria e família”, “aposentadoria e saúde do trabalhador”. Encontrou-se o total de 198 publicações, sendo 19 delas analisadas. Constatou-se a aposentadoria como um evento de vida e, a coincidência de sua ocorrência com a proximidade da velhice, além da estreita relação com as questões de saúde e de família, configurando-se um desafio durante o processo de envelhecimento. Concluiu-se que a inter-relação dos temas aposentadoria, envelhecimento, contexto familiar e a saúde do trabalhador estão em evidência nas publicações encontradas neste estudo.   Palavras-chave: Aposentadoria. Família. Saúde do trabalhador

Leitura de notícias e imaginário

Directory of Open Access Journals (Sweden)

Gislene Silva

2010-11-01

Full Text Available Pode a leitura de notícias provocar no leitor sensações estéticas, ajudá-lo a organizar significados, nutri-lo de experiências transcendentais? A investigação do jornalismo no âmbito da recepção e como narrativa cultural, potente em sua dimensão simbólico-mítica e imaginária, sugere resposta afirmativa. Leitores da revista Globo Rural, ao relatarem aspectos do pacto de leitura com a publicação, revelam fundamentos que levam a pesquisaa ultrapassar os limites da centralidade do jornalismo sustentada em fatos e acontecimentos objetivos. E, em sendo uma publicação configurada em sua maior parte por matérias de economia, técnicas e negócios agrícolas, as impressões de leitura indicam também a necessidade de se revisitar demarcações entre notícias factuais e não factuais, importantes e interessantes, de interessepúblico e de interesse do público. O que se pode perceber junto a esses leitores é que, mesmo a partir de empreendimento para a divulgação da realidade, algumas publicações jornalísticas se tornam ficcionais.

Founding a business inspired by close entrepreneurial ties: Does it matter for survival?

NARCIS (Netherlands)

de Jong, J.P.J.; Marsili, O.

2015-01-01

Founding a business may be inspired by close entrepreneurial ties, that is, business-owning relatives or friends. We analyze if and when such inspiration is associated with post-entry survival. Drawing on longitudinal data on 942 founders, we find a positive relationship only if founders start by

Wind power: public policies; Energia eolica: politicas publicas

Energy Technology Data Exchange (ETDEWEB)

Ferreira, Henrique Tavares; Faga, Murilo Tadeu Werneck [Universidade de Sao Paulo (USP), SP (Brazil). Inst. de Eletrotecnica e Energia. Programa Interunidades de Pos-graduacao em Energia]. E-mail: henrique@iee.usp.br; murfaga@iee.usp.br

2006-07-01

This paper presents the incentive models to the wind power applied in Germany and Denmark, two countries with great participation of wind power in their energetic matrixes, analysing the barriers found to the wind power development.

Ciencia, Salud Publica y Educación Medica.

Directory of Open Access Journals (Sweden)

José Felix Patiño Restrepo

1987-12-01

Full Text Available

Análisis Critico Del Panorama Actual.

El conocimiento biomédico ha crecido a una velocidad enorme en el presente siglo y en las últimas décadas ha avanzado mucho más que en el curso de toda su historia.

También en el presente siglo se han desarrollado en América Latina los conceptos de organización y de economía de la atención médica. en la medida que la opinión pública y los legisladores enfocan su atención hacia los costos del cuidado médico para el ciudadano. la financiación de los hospitales públicos y privados y la obligación del estado de proveer atención para aquellas personas sin acceso a servicios privados. La economía médica se convirtió en un área respetable, a la vez que básica y necesaria desde el punto de vista de la investigación, dentro del contexto general de las actividades médicas y de salud (1. Sin embargo, en otras latitudes ha surgido un peligroso fenómeno, el de la industria de la salud, que provee servicios con ánimo de lucro, dando lugar al denominado complejo médico-industrial que puede llegar a confundir los intereses del público con el de los inversionistas (8. Es así como aspectos relativos a la organización y a la economía de la atención médica son hoy un hecho de la vida diaria, allado de los tradicionales esfuerzos por mantener la excelencia en la calidad de la educación, la investigación y la prestación de servicios.

Estos fenómenos, de ocurrencia universal, también han sido observados en Colombia y en la América Latina. Pero en la medida que el desarrollo socioeconómico de la atención médica prima como preocupación estatal y aparece prioritario en el panorama político como reflejo de justas aspiraciones ciudadanas, lo cual repercute en el crecimiento de la organización de la seguridad social como servicio público, el sector de la educación médica. representado por las facultades de medicina y los hospitales de enseñanza, públicos y privados, sufre un alarmante deterioro no sólo en su operación y desarrollo. sino aún en su misma filosofía y principios fundamentales (15. Reconocidas autoridades académicas, como A. Neghme de Chile, han denunciado la crisis que afecta a la educación médica y a las universidades latinoamericanas (13, 14. Mucho del progreso alcanzado en el conocimiento biológico y en la aplicación de modernas tecnologías, lo cual significa toda una nueva perspectiva de la medicina y una nueva concepción de la educación médica, aún no ha llegado a nuestras facultades. Lamentablemente parece que buena parte de nuestro profesorado no ha registrado el prodigioso panorama de la nueva biología.

Lo más sobresaliente de la evolución histórica de la medicina en la segunda mitad del presente siglo. es el vertiginoso avance de la medicina como ciencia. La bioquímica celular, y ahora la biología en los niveles moleculares y submoleculares, han explotado como el nuevo y sobrecogedor campo que gobierna la educación y la investigación médicas. Philip Applewhite de Yale se refiere a “los dioses moleculares” (2, al señalar como la biología molecular significa algo que va más allá de la simple estructura y función orgánica. para determinar aún el mismo comportamiento humano: “nuestro comportamiento es controlado por moléculas, y por nada más … estas moléculas actúan como dioses. por así decir, gobernándonos aún más de lo que podemos imaginar … nuestro comportamiento se debe más a los eventos moleculares que ocurren
en nuestro interior que a los eventos que tienen lugar a nuestro alrededor”...

Debate sobre salud publica y despenalizacion del dopaje

Directory of Open Access Journals (Sweden)

Miguel Vicente Pedraz

2013-10-01

Full Text Available Este artículo pretende alertar de las contradicciones inherentes a la definición del deporte con relación a la salud y la educación. Tomando como referencia el dopaje, intenta elevar al debate público las repercusiones que la industria del rendimiento deportivo tiene en la salud pública. La práctica clandestina del dopaje conduce a muchos deportistas profesionales y aspirantes a la inseguridad sanitaria y a la desorientación ética de los practicantes aficionados y enseñantes del deporte. Por ello, se plantea la necesidad de discutir una eventual despenalización del dopaje en el deporte profesional.

Cuidado humanizado como Politica Publica. El caso peruano

Directory of Open Access Journals (Sweden)

Fredy Hernán Polo Campos

2017-04-01

Full Text Available Resumen Es una experiencia de trasferencia de conocimientos que posibilitó fortalecer el proceso de implementación de una política pública de cuidado humanizado en la Región La Libertad-Perú en el periodo 2007-2014 cuyo objetivo radica en redimensionar las relaciones de poder entre Estado y Sociedad Civil respecto al cuidado de la vida y la libertad, conceptos que dan sentido y fines a una política socio-sanitaria. La experiencia se basó en desarrollar e implementar un modelo de cuidado, iniciando por cuestionar el actual modelo de atención con visas a proponer un modelo orientado a preservar la salud y desarrollo de ciudadanía. Para ello se implementaron procesos de modelamiento de la prestación socio-sanitaria, se modificaron estructuras y se re-inventaron los procesos de gestión sanitaria. Sin duda esta experiencia requiere ser evaluada, fortalecida y mejorar, siendo necesario determinar su efectividad, eficacia y valorar el impacto en la salud y en el desarrollo de la población liberteña para garantizar sostenibilidad e inversión por parte de la clase técnico-política.

UMA ANÁLISE SISTEMÁTICA SOBRE ESTUDOS DE GESTÃO DE RECURSOS HUMANOS EM PEQUENAS E MÉDIAS EMPRESAS

Directory of Open Access Journals (Sweden)

¹SIQUEIRA, R.L.G

2015-12-01

Full Text Available O mercado de trabalho se caracteriza por uma forte flexibilidade contratual. O índice de rotatividade em alguns setores de negócio, apresenta taxas acima das médias nacionais. A gestão de recursos humanos nas organizações do século XXI enfrenta grandes desafios no repensar das suas formas de gestão. O objetivo do trabalho é fornecer uma visão sistemática sobre as publicações no tema de gestão de recursos humanos em pequenas e médias empresas. Este estudo prioriza encontrar documentos publicados que estão dispersos nas bases de pesquisa e permitir uma visão panorâmica a respeito do tema, através da utilização de um levantamento sistematizado efetuado em uma base disponível no portal de periódicos Capes, a base Scopus. Algumas questões estatísticas observadas neste trabalho constituem por: análise por ano de publicação; análise por área geográfica de publicação; análise por periódico de publicação; análise por área temática de assunto que concentram o maior número de publicações; análise por tipo de documento; e os autores que mais publicam, visando traçar um panorama geral desses eventos. Os procedimentos metodológicos utilizados caracterizam a pesquisa como predominantemente quantitativa do tipo descritiva, bibliográfica e documental. O estudo é operacionalizado através de uma ferramenta estatística básica para a gestão da informação e do conhecimento científico e tecnológico, o levantamento bibliométrico. Foram analisados 25 artigos e dentre os resultados do estudo, destaca-se que a gestão de recursos humanos é precária ainda quando se trata da implementação de procedimentos desta gestão em pequenas empresas. Outro resultado de destaque é que a maioria das aplicações estava relacionada à: empresas de pequeno porte. Desta forma, verificou-se: a situação que se encontra a produção científica dos trabalhos publicados em gestão de recursos humanos em pequenas e m

Keskerakond nurjas tunnustuse okupatsioonimuuseumi rajajale / Toomas Mattson

Index Scriptorium Estoniae

Mattson, Toomas, 1970-

2004-01-01

Keskerakond oli Tallinna linnavolikogus vastu Res Publica ettepanekule anda Tallinna teenetemärk väliseestlasele Olga Kistler-Ritsole, kes on annetanud 35 miljonit krooni okupatsioonide muuseumi rajamiseks

Ümberrivistumine mitte ainult paremal / Ivari Padar

Index Scriptorium Estoniae

Padar, Ivari, 1965-

2004-01-01

Eesti poliitikamaastikul toimuvast. Sotsiaaldemokraatlikust Erakonnast võib saada vasaktsentristlik koondav jõud, mis tõmbab endasse näiteks Res Publicas, Rahvaliidus ja Keskerakonnas pettunud liikmeid ja valijaid

Otvetshajet Juhan Parts, premjer-ministr / Juhan Parts

Index Scriptorium Estoniae

Parts, Juhan, 1966-

2005-01-01

Peaminister Juhan Parts selgitab Res Publica ja valitsuse korruptsioonivastast poliitikat ning loodab, et justiitsminister Ken-Marti Vaheri pakutud strateegia võitluses korruptsiooniga ei saa koalitsiooni lagunemise põhjuseks

Major trends in party system in Ukraine for 1998-2014 years

Directory of Open Access Journals (Sweden)

D. K. Nosenko

2015-01-01

Full Text Available The current party system of Ukraine, defined its main features and trends with regard of parliamentary elections 2014 was investigated. The classification, which distinguish the parliamentary system was determined. It is established that the party system has undergone significant changes compared to previous years. Thus, according to classification Mayra Ukrainian party system evolved from a secondary party system to a system of small parties because the two largest parties have 47.5% of votes in parliament. Meyer’s Index fell by almost a factor of 2, indicating that the party system became more competitive, the process of forming a coalition will be longer, and the stability of the government will be lower than in previous years. The calculated effective indices of the number of parties suggested Laakso, Taagepera and Golosov also show that the party system became more fragmented. Based on the analyzed results of parliamentary elections for 1998­2014 years, it has found that increasing or decreasing the percentage threshold of 1%, not significantly affected by the number of parties represented in Parliament; none of the parties could not be present in every convocation; there is uncertainty in electoral preferences.

Makit Lld: A Price above Rubies

DEFF Research Database (Denmark)

Hockerts, Kai; Jorem, Kaja; Walker Pedersen, Kristina

2016-01-01

. The case lends itself, furthermore, to the introduction of a number of other topics related to social entrepreneurship, such as, for example, how to organize a founder team, the ownership structures, and how to plan for the risk of one founder leaving the team. Moreover, the case allows discussing...

Sovet da neljubov / Josef Kats, Aleksandra Manukjan

Index Scriptorium Estoniae

Kats, Josef, 1977-

2005-01-01

Tallinnas vahetunud koalitsioon tõi muutusi ka Vene kultuurikeskuse juhtimisse, linnapea Tõnis Paltsi soov vahetada välja keskuse direktor tõi uued vastuolud Res Publica ja Reformierakonna suhetesse

Kings Today, Rich Tomorrow

DEFF Research Database (Denmark)

Fattoum, Asma

2013-01-01

This study investigates the King vs. Rich dilemma that founder-CEOs face at IPO. When undertaking IPO, founders face two options. They can either get rich, but then run the risk of losing the control over their firms; or they can remain kings by introducing defensive mechanisms, but this is likel...

Sanjoy Hazarika

Indian Academy of Sciences (India)

Sanjoy Hazarika is the Director, Commonwealth Human Rights Initiative. He was the founder Director, Centre for North-East Studies and Policy Research, Jamia Millia Islamia, New Delhi and also holds Dr Saifuddin Kitchlew Chair. He is the founder and managing trustee of North-East Studies, which runs the pioneering ...

Separation of Powers and the Legislative Power.

Science.gov (United States)

Rossum, Ralph A.

1986-01-01

Addresses the contribution of separation of powers and checks and balances in resolving the rival defects of democratic ineptitude and majority tyranny as the Founders framed the Constitution. Contends the Founders structured the government so that the three branches could keep each other in their proper places. Discusses Anti- Federalist…

Aasta pärast on Eestil uus valitsus / Max Kaur

Index Scriptorium Estoniae

Kaur, Max, 1969-

2003-01-01

Autori sõnul on Res Publica uus poliitika osutunud euroremonditud vanaks poliitikaks ning ta ennustab, et järgmiseks sügiseks on Eestil uus valitsuskoalitsioon, mille peaminister on keskerakondlane

Parts lubab eestlasliku korra riigis majja lüüa / Juhan Parts ; interv. Urmet Kook

Index Scriptorium Estoniae

Parts, Juhan, 1966-

2003-01-01

Res Publica esimees Juhan Parts vastab küsimustele erakonna valimislubaduste, valimisloosungi, sündimuspoliitika, EL-iga liitumise kohta, Eesti-Vene suhetes läbimurde saavutamise võimalikkusest, parteide rahastamisest

G1738R is a BRCA1 founder mutation in Greek breast/ovarian cancer patients: evaluation of its pathogenicity and inferences on its genealogical history.

Science.gov (United States)

Anagnostopoulos, Theodore; Pertesi, Maroulio; Konstantopoulou, Irene; Armaou, Sofia; Kamakari, Smaragda; Nasioulas, George; Athanasiou, Athanassios; Dobrovic, Alex; Young, Mary-Anne; Goldgar, David; Fountzilas, George; Yannoukakos, Drakoulis

2008-07-01

heterogeneity in the Greek population, the identification of a frequent founder mutation greatly facilitates genetic screening.

Understanding health care reform: bridging the gap between myth and reality

National Research Council Canada - National Science Library

Feldman, Arthur M

2012-01-01

... responsibility for the validity of all materials or the consequences of their use. The authors and publishers have attempted to trace the copyright holders of all material reproduced in this publica...

Lipsuta pintsaklipslane / Ken-Marti Vaher ; interv. Paavo Kangur

Index Scriptorium Estoniae

Vaher, Ken-Marti, 1974-

2008-01-01

Rahvusvahelise vaatlejana Gruusias viibinud Riigikogu liige Gruusia presidendivalimistest ja riigi arengust viimastel aastatel, korruptsioonist ja poliitilisest eliidist Eestis, Res Publica loomisest ja rahastamisest, oma perekonnast, spordiga tegelemisest. Lisa: Ken-Marti Vaher

Hariduspoliitikas ilmnevad üksmeele märgid / Mailis Reps

Index Scriptorium Estoniae

Reps, Mailis, 1975-

2006-01-01

Ilmunud ka: Severnoje Poberezhje 7. juuni lk. 2, Nädaline 10. juuni lk. 2. Haridusminister Mailis Reps Res Publica ja Isamaaliidu ühisest haridusprogrammist ning juba teostumas hariduspoliitilistest eesmärkidest

Slanets - Estonskaja nokia / Nikolai Golubev ; interv. Juliana Preobrazhenskaja

Index Scriptorium Estoniae

Golubev, Nikolai

2004-01-01

Narva linnavolikogu liige ja Res Publica kandidaat europarlamendi valimistel selgitab, milline on Narva koht Euroopa Liidus, venekeelse elanikkonna valimisaktiivsuse tõstmise võimalusi ning oma suhtumist Euroopa Liidu ühtsesse konstitutsiooni

Hindi tagandamine võib viia võimukoalitsiooni lagunemiseni Kohtla-Järvel / Erik Gamzejev

Index Scriptorium Estoniae

Gamzejev, Erik, 1967-

2003-01-01

Ilmunud ka: Severnoje Poberezhje 26. sept. lk. 1. Keskerakonna soov saada endale Kohtla-Järve linnapea ametikoht võib viia Keskerakonna ja endiste Res Publica liikmete vahel sõlmitud koalitsiooni lagunemiseni

Trad. Daniele Vitale, Arquitectos portugueses. Identidade, nacionalidade, modernidade

OpenAIRE

Marnoto, Rita

2010-01-01

(2010. Trad.). Daniele Vitale, Arquitectos portugueses. Identidade, nacionalidade, modernidade, JA Jornal Arquitectos. Publicação Trimestral da Ordem dos Arquitectos Portugal, 237, 93-101. ISSN 0870 1504 Trad. Daniele Vitale

La cittadinanza amministrativa. Una nuova prospettiva per la partecipazione

Directory of Open Access Journals (Sweden)

Gregorio Arena

2011-05-01

Full Text Available Io voglio in questo lavoro approciare il tema della cittadinanza attiva nella publica amministrazione, metendo in fuoco il concetto della partecipazione sociale. Parole-chiavi: Cittadinanza. Democrazia. Pubblica Amministrazione.

Founder lines for improved citrus biotechnology

Science.gov (United States)

This article discusses the research needed to develop the RMCE strategy and molecular assays for site-specific recombinases as tools for genome manipulation. Explanation of genetic engineering used to generate transgenic citrus plants to exhibit a novel phenotype, but not to contain the recombinase...

Founders of fish culture - European origins

Science.gov (United States)

Fish, F.F.

1936-01-01

Just where true fish culture appeared in history depends entirely upon what one considers fish culture to be. If the transportation of fishes from regions of plenty to those of few is to be regarded as fish culture - as it is by some even today - then this story should start in remotest antiquity and deal with an amazing series of failures. However, fish culture to be classed as a science must include far more than mere transportation, it must include a deliberate effort on the part of man to master a technique of fish raising which will yield results far superior to Nature's. Accordingly, the wheel of history must be spun forward to the fifteenth century, A. D., when man first conceived the idea that with care and exactitude, he could improve upon Nature. The fish cultural efforts of the Chinese, the Egyptians, the Greeks, and the Romans may be skipped over in a hurry, for they represented little more than the transportation and rearing of wild fish. With the renaissance of modern civilization in Europe came the birth of scientific fish culture.

Status Quo in Kadriorg (Presidential residence) or a coalition based on the "world view"? / Anna-Maria Galojan

Index Scriptorium Estoniae

Galojan, Anna-Maria, 1982-

2011-01-01

29. augustil 2011 Eestis toimuvatel presidendivalimistel peaks võitma praegune riigipea Toomas Hendrik Ilves, kuna Reformierakond, Isamaa ja Res Publica Liit ja Sotsiaaldemokraatlik Erakond on lubanud teda toetada. Autor kahtleb Eesti demokraatlikkuses

Õpetajaks hakkamise eest võib tulevikus saada 200 000 krooni / Mirko Ojakivi

Index Scriptorium Estoniae

Ojakivi, Mirko

2007-01-01

Isamaa ja Res Publica Liit lubab võimule pääsedes maksta esmakordselt tööle asuvale pedagoogilise kõrgharidusega õpetajale 200 000 krooni stardiraha. Endise haridusministri Tõnis Lukase selgitus

"K borbe za delo kapitalizma - bud gotov!" / Vjatsheslav Ivanov

Index Scriptorium Estoniae

Ivanov, Vjatsheslav

2005-01-01

Autor võrdleb Res Publica noorpoliitikuid 1970.-1980. aastate komsomolijuhtidega ning ütleb, et entusiasmist, võitluslikkusest ja lubaduste andmisest on vähe, et riiki juhtida, vaja on ka teadmisi, kogemust

Juhan Parts : Eesti saab uued ministrid paari-kolme nädalaga / Juhan Parts ; interv. Toomas Sildam

Index Scriptorium Estoniae

Parts, Juhan, 1966-

2003-01-01

Res Publica esimees Juhan Parts tunnistab Reformierakonna ja Rahvaliiduga peetavate võimukõneluste takerdumist päevaprobleemidesse, kuid loodab aprilli esimeseks pooleks valitsuskoalitsiooni kokku saada. Vt. samas: Parts kohtus Rüütliga

ECONOMIA CRIATIVA: UM ESTUDO BIBLIOMÉTRICO DOS ARTIGOS PUBLICADOS NOS ANAIS EnANPAD E PERIÓDICOS DO SPELL DE 2010 A 2015

Directory of Open Access Journals (Sweden)

Francisco Laurêncio Rodrigues da Silva

2017-08-01

Full Text Available A área da economia criativa ou indústrias criativas tem sido cada vez mais explorada nos trabalhos realizados. Objetivando uma utilização frequente e uma ótima ferramenta geradora de renda através da própria cultura local, o que demonstra a profissionalização das empresas e o comprometimento com o bem-estar pessoal, profissional dos colaboradores e o social visando o desenvolvimento não só da entidade, como também da comunidade. Com o intuito de contribuir no campo de estudo da economia criativa, este artigo realizou um estudo bibliométrico, por meio das publicações de artigos do EnANPAD e SPELL sobre as indústrias criativas nos períodos de 2010 a 2015, tendo como o objetivo identificar as principais contribuições na área da economia criativa nos anais e periódicos desses dois importantes instrumentos da administração. Quanto às categorias identificadas na pesquisa, conclui-se que é uma área considerada nova, mas as produções científicas estão acompanhando a evolução do empreendedorismo, principalmente com o quantitativo de publicações e estudos realizados nos encontros do EnANPAD e SPELL, que aparentemente contou com poucas publicações nos anais.

Monitoramento e Controle de Projetos de Desenvolvimento de Software com o Scrum: Avaliação da Produção Científica

Directory of Open Access Journals (Sweden)

Alexandre Guido Vallerão

2013-12-01

Full Text Available O objetivo principal deste estudo é a realização de bibliometria da produção científica dos últimos cinco anos sobre processos de monitoramento e controle de projetos de desenvolvimento de software gerenciados com o método Scrum, envolvendo as principais bases de publicações de periódicos, teses e dissertações. Para isso, foram definidos como eixos temáticos os métodos ágeis, o método Scrum, software e monitoramento e controle de projetos. Foram pesquisadas bases de publicações nos portais Capes e Web of Knowledge, sendo a relevância dos artigos encontrados determinada pelo h-index. Com base no conjunto de publicações localizadas, foram determinadas suas principais abordagens sobre aqueles processos de monitoramento e controle. Os resultados da pesquisa indicam uma pequena produção científica destinada ao monitoramento e controle de projetos de desenvolvimento de software com uso de métodos ágeis, revelando em número ainda menor aqueles com o uso do método Scrum, o que sugere oportunidades de pesquisa e consequente incremento da produção científica relacionada a esse tema contemporâneo às organizações.DOI:10.5585/gep.v4i2.154

Revistas científicas e a contituição de campo de estudos de gênero: um olhar desde as "margens"

Directory of Open Access Journals (Sweden)

Maria Margaret Lopes

2004-01-01

Full Text Available http://dx.doi.org/10.1590/S0104-026X2004000300013 Este artigo trata do papel das revistas científicas na construção do campo de estudos de gênero. A partir da sociologia da ciência, da história da ciência e da experiência das autoras na publicação dos CADERNOS PAGU, examina-se a interação desta com a agenda feminista. Busca-se discutir o efeito das tensões e “negociações” na publicação de revistas científicas, além da constituição do campo de estudos de gênero. As ações políticas, as tensões, as negociações, o processo de “peer-review”, o “controle” do conhecimento científico e as normas editoriais são analisadas no quadro das publicações cientificas – a formação de um campo de pesquisa e a reprodução de centralidade/periferia no Brasil. Finalmente, aponta-se para questões relativas ao aumento da visibilidade da Revista, da diversificação do seu conteúdo e da cooperação com pesquisadores latino-americanos e de outras partes do mundo.

Ecohealth Research in Practice

International Development Research Centre (IDRC) Digital Library (Canada)

Research, education, and practice in ecohealth have seen almost logarithmic ... Health Organization; Instituto Nacional de Salud Publica, Mexico; and IDRC). ..... rates and improving the control of major diseases like tuberculosis and malaria, ...

"Nizkii reiting - eto problema" / Taavi Veskimägi ; interv. Tatjana Opekina

Index Scriptorium Estoniae

Veskimägi, Taavi, 1974-

2006-01-01

Res Publica liidri Taavi Veskimägi suhtumisest president Arnold Rüütli võimalikku jätkamisse, hinnangutest tuntud poliitikute lahkumisele Res Publicast, ühenduse kujunemisest parteiks, partei reitingust, valitseva koalitsiooni kriitika

Ülo Vooglaiule ei ole ükskõik, mis Eestist saab / Ülo Vooglaid ; interv. Maris Balbat

Index Scriptorium Estoniae

Vooglaid, Ülo, 1935-

2005-01-01

Sotsioloog ja endine Riigikogu liige oma lapsepõlvest, haridusteest, tegevusest Tartu Ülikooli sotsioloogialaboratooriumis, kommunistlikus parteis, Rahvarindes, Koonderakonnas ja Res Publicas, Lohu külavanema ametist, perekonnast, hobidest ja väärtushinnangutest

Infrastructure Management Information System User Manual

Science.gov (United States)

1998-10-01

This publication describes and explains the user interface for the Infrastructure Management Information System (IMIS). The IMIS is designed to answer questions regarding public water supply, wastewater treatment, and census information. This publica...

Muutused transiidis panid uusi lahendusi otsima / Roger Allas

Index Scriptorium Estoniae

Allas, Roger

2008-01-01

Transiidikonverentsil Transestonia tehti kokkuvõte 2007. aasta transiidimahtudest ja otsiti lahendusi tulevikuks. Vt. samas: Tanel Raig. Juhtparteid vaatavad transiidi arendamisel eri suundades; Isamaa ja Res Publica Liidu kommentaar transiidi ja konteinerterminali rajamise kohta

Negrazhdanskii dolg koalitsii / Andrei Titov

Index Scriptorium Estoniae

Titov, Andrei, 1979-

2008-01-01

Autor kirjutab levivatest kuuldustest, et kodakondsuse saamise korda võidakse lihtsustada. Isamaa ja Res Publica Liidu pressisekretäri Jekaterina Rikkase, peaminister Andrus Ansipi, rahvastikuminister Urve Palo ja riigikogu liikme Vladimir Velmani arvamusi

マーケティングのパイオニア : 森永太一郎と鈴木三郎助

OpenAIRE

森田, 克徳

1998-01-01

This paper attempts to clarify the business activities of Taichiro Morinaga and Saburosuke Suzuki, especially of marketing. The former is the founder of Morinagaseika which was inagurated in 1899, and the latter is the founder of Ajinomoto established in 1908. Morinagaseika is a first-mover in the confectionery industory in Japan and Ajinomoto in the seasoning industory too.

Generation of transgenic mice producing fungal xylanase in the ...

African Journals Online (AJOL)

DR TONUKARI NYEROVWO

express exogenous digestive enzymes, since a single- stomached animal, such as a pig, can secret .... transgenic founder mice; 1 to15 are fifteen wild-type founder mice; M, marke; β-actin, endogenous control. (C) Identification of transgenic mice by ... 61.48±0.34%), gross energy digestibility (WT vs. TG = 68.79±0.51% vs.

The relationship between male moth density and female mating success in invading populations of Lymantria dispar

Science.gov (United States)

Patrick C. Tobin; Ksenia S. Onufrieva; Kevin W. Thorpe

2012-01-01

The successful establishment of non-native species in new areas can be affected by many factors including the initial size of the founder population. Populations comprised of fewer individuals tend to be subject to stochastic forces and Allee effects (positive-density dependence), which can challenge the ability of small founder populations to establish in a new area....

Roman Policies towards Antiochus III and the Greeks from Winter 197/196 B.C. to Autumn 196 B.C.

Directory of Open Access Journals (Sweden)

Deutschmann, Eike Hellmut

2012-01-01

Full Text Available In the Second Macedonian War (200-196 B.C., the res publica reduced the strength of the enemy King Philip V apparently to establish a new political order in Southern Balkans: Assumedly a pro-Roman balance of forces should prevail there, untainted by influence of another major power. A particular senatorial policy towards the Greeks probably did not exist before the fighting in Hellas came to an end in summer 197 B.C. In the same year, the Seleucid king Antiochus III brought large parts of the west coast of Asia Minor under control and set about crossing the Hellespont. Rome subsequently stylized itself as the guardian of freedom for the Greeks living in Hellas and Asia Minor. The statesmen of the res publica could have perceived Antiochus’ expansion as a threat to the mentioned new order. Therefore, the Roman Policy of Freedom was possibly applied primarily to take action against the Seleucid king. Die res publica verminderte im Zweiten Makedonischen Krieg (200-196 a.c. die Macht des gegnerischen Königs Philipp V - anscheinend um eine neue politische Ordnung im südlichen Balkanraum zu etablieren: Vermutlich sollte dort ein romfreundliches Kräftegleichgewicht vorherrschen, auf das keine andere Großmacht Einfluß hat. Eine speziell an die Griechen gerichtete Politik seitens des römischen Senats gab es wahrscheinlich nicht vor Ende der Kampfhandlungen in Hellas im Sommer 197 a.c. In dem Jahr erweiterte der seleukidische König Antiochos III. seinen Einflussbereich auf große Teile der kleinasiatischen Westküste und schickte sich an, den Hellespont zu überqueren. Rom stilisierte sich in der Folgezeit zum Freiheitsgarant der in Hellas und Kleinasien lebenden Griechen. Antiochos Expansion könnte von den Staatsmännern der res publica als Bedrohung der genannten neuen Ordnung angesehen worden sein. Demzufolge wurde die römische Freiheitspolitik möglicherweise in erster Linie angewendet, um gegen den seleukidischen König vorzugehen.

POPULATION ANALYSIS OF THE LOCAL ENDANGERED PŘEŠTICE BLACK-PIED PIG BREED

Directory of Open Access Journals (Sweden)

Emil Krupa

2015-09-01

Full Text Available The pedigree analysis of the local endangered Přeštice Black-Pied pig breed (n=19 289 was performed. Animals born within the period 2012-2014 were assumed as the reference population (n=1 374. The pedigree completeness index reached 100% for four generations back. The 100 % of the genetic pool was explained by 66 ancestors. Although all animals of the reference population were inbred, 57% of them had inbreeding less than five percent. Average inbreeding, co-ancestry coefficient and rate of inbreeding reached 4.93%, 13.48% and 1.29% in reference population, respectively. The effective population size calculated by four different methods varied from 32 to 91 animals in 2014. Average generation interval, average family size for sire and dam parents was 2.5, 17.46 and 6.5 animals, respectively. Total number of founders, effective number of founders, effective number of founders’ genomes and effective number of non-founders genomes reached values 299, 98.05, 21.92 and 28.23 founders, respectively. The average genetic diversity (GD loss was 13.71% in reference population. The GD loss has increased within the last three year period mainly due to the random genetic drift (77.6% and by unequal contribution of founders (22.4%. The Preštice Black-Pied breed is highly endangered with GD loss. Mating of closely related animals has to be prevented in breeding and mating program of this breed.

Potshemu ne goditsja nõheshnjaja sistema nalogooblazhenija?

Index Scriptorium Estoniae

2003-01-01

Oma arvamuse Eesti maksusüsteemi kohta ütlevad: Siim Kallas - Reformierakond, Tõnis Palts - Res Publica, Nikolai Maspanov - VEE, Eiki Nestor - Rahvaerakond Mõõdukad, Tiit Toomsalu - ESDTP, Küllo Arjakas - Keskerakond, Mart Opmann - ERL

Rakendav rahulolematus / Enn Soosaar

Index Scriptorium Estoniae

Soosaar, Enn, 1937-2010

2007-01-01

Autor arutleb parteide valijate üle Riigikogu valimistel ja leiab, et Riigikogu koosseis oleneb suurel määral sellest, kuivõrd suudavad erakonnad võita Res Publicas pettunud ja muidu rahulolematute valijate poolehoidu

3 küsimust / interv. Elina Kononenko

Index Scriptorium Estoniae

2005-01-01

Andres Kõivu (Isamaaliit), Ivari Padari (Sotsiaaldemokraatliku Erakond), Ülle Puustusmaa (Res Publica), Tõnu Antoni (Keskerakond), Ivi Eenmaa (Reformierakond), Toivo Teekeli (Kristliku Rahvapartei) ja Arno Silla (Rahvaliit) linnapeakandidaatide ja parteide esindajate vastused kohalike valimiste teemal

Grupo terapêutico em fonoaudiologia: revisão de literatura Therapeutic Group in Speech Language and Hearing Sciences: literature review

Directory of Open Access Journals (Sweden)

Vanessa Veis Ribeiro

2012-06-01

Full Text Available TEMA: grupo terapêutico fonoaudiológico. OBJETIVO: revisar, de maneira sistemática, pesquisas advindas de todas as áreas da Fonoaudiologia que envolveram abordagens grupais, na realidade brasileira. Foi realizada busca nos bancos de dados das bases SciELO e LILACS no período de 2005 a 2010. Foram selecionados os estudos cujos conteúdos dos resumos relacionavam-se com o objetivo da presente pesquisa. Como forma de categorização dos dados, optou-se pela análise dos seguintes aspectos: público-alvo, ano de publicação e área da Fonoaudiologia envolvida. CONCLUSÃO: observa-se um número restrito de publicações referentes ao tema (28 artigos. A maior parte dos trabalhos foi realizada com público adulto, seguido de grupos de crianças, adolescentes e idosos, respectivamente. Foi baixo o índice de artigos envolvendo grupos de familiares. Dentre as áreas da Fonoaudiologia, a de Linguagem tem o maior número de publicações envolvendo grupos, seguida pelas áreas de Voz e Audiologia. Em relação ao ano de publicação, observou-se que, de maneira geral, tem havido decréscimo do número de publicações sobre o assunto desde o ano de 2007. Concluiu-se que é restrito o número de publicações sobre grupo terapêutico na área de Fonoaudiologia. Considera-se que além de novos estudos sobre a prática grupal, outros trabalhos de revisão devam assumir a análise de categorias como aspectos metodológicos, estratégias de atuação e resultados obtidos nos processos terapêuticos grupais.BACKGROUND: therapeutic Group in Speech Language and Hearing Sciences. PURPOSE: to review, systematically, researches stemming from all areas of speech therapy that involved group approaches, in Brazil. We conducted a search in LILACS and SciELO databases in the period from 2005 to 2010. We selected studies where the contents of the abstracts were related to the objective of this research. As a way of categorizing such data, we chose to analyze the

Recursos Hídricos Subterrâneos de Portugal, Componente Fundamental do Desenvolvimento. Sua Caracterização Quantitativa e Qualitativa.

OpenAIRE

Lobo Ferreira, J. P. C.

1993-01-01

****** Artigo aceite para publicação num número especial sobre águas subterrâneas da revista Recursos Hídricos da Associação Portuguesa dos Recursos Hídricos, Dezembro de 1993. ****** ****** ****** ******

Arnold Rüütel: "Kohati jääb meie erakondadel puudu sisemisest demokraatiast." / Arnold Rüütel ; intervjueerinud Urmo Soonvald

Index Scriptorium Estoniae

Rüütel, Arnold, 1928-

2004-01-01

President Arnold Rüütel vastab küsimustele, mis puudutavad vedurijuhtide streiki, noorte arstide lahkumist välismaale, Rahvaliidu saadikurühma tekkimist Tallinna volikogus, Res Publica ja Reformierakonna võimalikku liitumist, Leedu-visiiti

Partija profsojuzam ne ukaz / Nikolai Govorov

Index Scriptorium Estoniae

Govorov, Nikolai

2007-01-01

Balti elektrijaama ametiühingujuhi, Isamaa ja Res Publica kandidaadi parlamendivalimistel Vladimir Ponjatovski üleskutsest Narva elanikele avaldada protesti 7. veebr. minutilise vaikimisega. Põhjuseks tuuakse Eesti poliitikute kavatsus teisaldada pronkssõdur. Pöördumise tekst

奥运短讯

Institute of Scientific and Technical Information of China (English)

无

2003-01-01

Olympic Games FounderRemembered A seminar to mark the birthday ofPierre de Coubertin,founder of themodern Olympic Games,was held inBeijing on January 1.Jiang Xiaoyu,vice president of theBeijing Olympic Games OrganizingCommittee,senior IOC member HeZhenliang and Olympic historian SunBaoli delivered speeches in memory ofMr.Coubertin who Was born OnJanuary 1,1863.

Pomjataja võborami niva obrazovanija / Jevgenija Garanzha

Index Scriptorium Estoniae

Garanža, Jevgenija, 1979-

2005-01-01

Res Publica ja Keskerakond loodavad sügisel toimuvatel kohalikel valimistel omavahel jagada enamuse venekeelse kogukonna valijate häältest. Tähelepanu alla on võetud haridust puudutavad küsimused, konfliktidest Narvas ja Paides

Mihkel Oviiril jääb sotside ja IRLi toetus saamata / Helga Koger

Index Scriptorium Estoniae

Koger, Helga, 1945-

2008-01-01

Isamaa ja Res Publica Liidu parlamendifraktsioon otsustas mitte toetada president Toomas Hendrik Ilvese poolt esitatud Mihkel Oviiri kandidatuuri riigikontrolöri ametikohale. Reformi- ja Keskerakonna üksmeel aga kindlustab Mihkel Oviirile riigikontrolöri teise ametiaja

Ettevaatust, uus pseudoläänlus vene ideoloogias! / Andres Herkel

Index Scriptorium Estoniae

Herkel, Andres, 1962-

2008-01-01

Ilmunud ka: Eesti Eest = Za Estoniju : Izdanije objedinenija "Sojuz Otetshestva i Res Publica" 14. aug. 2008, lk. 7. Ajalehes Rossiiskaja Gazeta ilmunud Sergei Karaganovi artiklist, kus ta visandab Venemaa globaalse arengu strateegia ja unistab Venemaa moderniseerimisest

Tööjõu maksukoormuse vähendamine parandab riigi konkurentsivõimet / Margit Aedla

Index Scriptorium Estoniae

Aedla, Margit, 1970-

2003-01-01

Res Publica liige, maksuküsimustega tegelev Taavi Veskimägi arvab, et hea maksusüsteem peaks tagama tasakaalu, sotsiaalse õigluse ja majanduskeskkonna atraktiivsuse. Lisad: Maksude kasutamise otstarbekus on tähtis ; Sõber ja vaenlane

20. september 2008 - tähtis päev / Kelly Kipper

Index Scriptorium Estoniae

Kipper, Kelly

2008-01-01

Ilmunud ka: Eesti Eest = Za Estoniju : Izdanije objedinenija "Sojuz Otetshestva i Res Publica" 18. sept. lk. 7. Autor räägib Noorte Konservatiivide ja Noor-Isamaa ühinemisest ja sellest, miks seda varem pole tehtud

2009. aasta eelarvest 2010. aastasse vaadates / Mart Laar

Index Scriptorium Estoniae

Laar, Mart, 1960-

2008-01-01

Erakonna Isamaa ja Res Publica Liit esimees avalikustab 2009.aasta eelarve arutelul välja käidud ettepanekud ja teavitab arutelu tulemused. Tekst pärineb Mart Laari blogist http://blog.irl.ee/Mart_ Laar/

Koren konflikta - v neftetranzite / Jelena Levina

Index Scriptorium Estoniae

Levina, Jelena

2004-01-01

Ühendus "Narvamaa" jälgib murega Keskerakonna ja Res Publica konflikti Riigikogus ning Narva linnavolikogus, mis jätab Narvast mulje kui madala poliitilise kultuuriga linnast, poliitilisest võitlusest Venemaal ja võimalikust huvist Eesti vastu

Aare Anderson : Elva-taoline väikelinn on parimaid kohti elamiseks / Aare Anderson ; interv. Mare Nõmmik

Index Scriptorium Estoniae

Anderson, Aare, 1966-

2006-01-01

Elva endine linnapea ja aselinnapea, rahandusministeeriumi töötaja vastab küsimustele, mis on seotud tema ametikohaga, Elvaga, võimalusega siduda end tulevikus poliitikaga. Isamaa ja Res Publica Liidu loosungist "Õnn ei ole rahas"

NCG61/24: Plan de Estudios de M??ster en Biomedicina Regenerativa

OpenAIRE

Universidad de Granada

2012-01-01

Plan de Estudios de M??ster en Biomedicina Regenerativa. Resoluci??n de 5 de marzo de 2012, de la Universidad de Granada, por la que se publica el plan de estudios de M??ster en Biomedicina Regenerativa

Eesti kolmas tulemine / Mart Laar

Index Scriptorium Estoniae

Laar, Mart, 1960-

2008-01-01

Ilmunud ka: Eesti Eest = Za Estoniju : Izdanije objedinenija "Sojuz Otetshestva i Res Publica" 15. mai 2008, lk. 1. Riigikogu liige kirjutab Eesti seismisest teelahkmel, kus majandus on sattunud probleemidesse, mille lahendamiseks peab olema valmis langetama julgeid otsuseid

Jüri Adams : ERSP võitis hirmu / Jüri Adams

Index Scriptorium Estoniae

Adams, Jüri, 1947-

2008-01-01

Ilmunud ka: Eesti Eest = Za Estoniju : Izdanije objedinenija "Sojuz Otetshestva i Res Publica" 14. aug. 2008, lk. 8. ERSP üks asutajaliikmetest vastab küsimustele, mis puudutavad sündmusi 1988. aastal, partei loomist, Eesti poliitikat

Home stretch for Ilves

Index Scriptorium Estoniae

2011-01-01

Suure tõenäosusega saab uueks presidendiks taas praegune riigipea Toomas Hendrik Ilves, sest teda on lubanud toetada Isamaa ja Res Publica Liit, Reformierakond ja Sotsiaaldemokraatlik Erakond, mis annab talle Riigikogu poolthäälte enamuse

A frozen record of density-driven crustal overturn in lava lakes: The example of Kilauea Iki 1959

Science.gov (United States)

Stovall, W.K.; Houghton, Bruce F.; Harris, A.J.L.; Swanson, D.A.

2009-01-01

Lava lakes are found at basaltic volcanoes on Earth and other planetary bodies. Density-driven crustal foundering leading to surface renewal occurs repeatedly throughout the life of a lava lake. This process has been observed and described in a qualitative sense, but due to dangerous conditions, no data has been acquired to evaluate the densities of the units involved. Kilauea Iki pit crater in Hawai'i houses a lava lake erupted during a 2 month period in 1959. Part of the surface of the Kilauea Iki lake now preserves the frozen record of a final, incomplete, crustal-overturn cycle. We mapped this region and sampled portions of the foundering crust, as well as overriding and underlying lava, to constrain the density of the units involved in the overturn process. Overturn is driven by the advance of a flow front of fresh, low-density lava over an older, higher density surface crust. The advance of the front causes the older crust to break up, founder, and dive downwards into the lake to expose new, hot, low-density lava. We find density differences of 200 to 740 kg/m3 between the foundering crust and over-riding and under-lying lava respectively. In this case, crustal overturn is driven by large density differences between the foundering and resurfacing units. These differences lead, inevitably, to frequent crustal renewal: simple density differences between the surface crust and underlying lake lava make the upper layers of the lake highly unstable. ?? Springer-Verlag 2008.

La nueva contraloria social en la gestion publica mexicana

Directory of Open Access Journals (Sweden)

Jimenez, E

2005-07-01

Full Text Available The aim of this article is to bring abouthe typical mechanisms of control in the administration, its application to public management and the new concept of social regulation. To obtain this, the author briefly mentions the basic concepts of control in a private context,he control mechanisms in the public sector, and the shaping of the social regulation asa means of public participation.

das publicações em periódicos nacionais

Directory of Open Access Journals (Sweden)

Marléa Chagas Moreira

2006-01-01

Full Text Available Estudio de clasificación sobre la producción del conocimiento en la enfermería en oncología. Los objetivos son: identificar las publicaciones en la enfermería en oncología en el período entre 1994 y 2004 y, analizar en las publicaciones, los aspectos epistemológicos señalados en las tematicas focalizadas y en el encuadramiento teorico-metodológico adoptado en los estudios. El referencial teorico-metodológico conjuntamente a una metodología epistemológica para la investigación en la enfermería. Fueram utilizados como fuentes de datos tres periódicos: la Revista Brasileña de Enfermería, la Revista Latinoamericana de Enfermería y la Revista Brasileña de Cancerología . De acuerdo con los resultados, las autoras consideran que el conocimiento producido en el área de la enfermería oncológica éstos son consistentes con la complejidad y las tentativas de explicación sobre el arte de cuidar de los clientes y con los esfuerzos de ampliar los criterios y los patrones asistenciales.

Institucionalizacao da saude publica paulista nos anos 1930-1940

Directory of Open Access Journals (Sweden)

Andre Mota

2013-10-01

Full Text Available O objetivo do estudo foi interpretar e compreender a institucionalização da saúde pública paulista nos anos 1930-1940, com base na história das especialidades médicas. Foram analisadas novas fontes documentais em diálogo com a literatura existente, levando à identificação de novos indícios relativamente à questão eugênica e à presença de crenças religiosas de médicos como um movimento social. Os médicos, à medida que se especializavam como sanitaristas, propunham um projeto para elevar a raça brasileira, mesclando discursos higienistas com ações sanitárias. São Paulo buscou a primazia nesse projeto, por se acreditar um Estado detentor de uma raça já constituída de “homens historicamente saudáveis”. Crenças religiosas influenciaram o debate e as decisões de época para a ordem sanitária. Historicamente, o discurso sanitário compõe questões técnico-científicas com as político-ideológicas e as culturais, produzindo uma mescla dos diferentes interesses e perspectivas de ordem corporativa da profissão.

Change in genetic size of small-closed populations: lessons from a domestic mammal population

Directory of Open Access Journals (Sweden)

Farhad Ghafouri-Kesbi

2010-01-01

Full Text Available The aim of this study was to monitor changes in genetic size of a small-closed population of Iranian Zandi sheep, by using pedigree information from animals born between 1991 and 2005. The genetic size was assessed by using measures based on the probability of identity-by-descend of genes (coancestry, f, and effective population size, Ne, as well as measures based on probability of gene origin (effective number of founders, f e, effective number of founder genomes, f g, and effective number of non-founder genomes, f ne. Average coancestry, or the degree of genetic similarity of individuals, increased from 0.81% to 1.44% during the period 1993 to 2005, at the same time that Ne decreased from 263 to 93. The observed trend for f e was irregular throughout the experiment in a way that f e was 68, 87, 77, 92, and 80 in 1993, 1996, 1999, 2002, and 2005, respectively. Simultaneously, f g, the most informative effective number, decreased from 61 to 35. The index of genetic diversity (GD which was obtained from estimates of f g,decreased about 2% throughout the period studied. In addition, a noticeable reduction was observed in the estimates of f ne from 595 in 1993 to 61 in 2005. The higher than 1 ratio of f e to f g indicated the presence of bottlenecks and genetic drift in the development of this population of Zandi sheep. From 1993 to 1999, f ne was much higher than f e, thereby indicating that with respect to loss of genetic diversity, the unequal contribution of founders was more important than the random genetic drift in non-founder generations. Subsequently, random genetic drift in non-founder generations was the major reason for f e> f ne. The minimization of average coancestry in new reproductive individuals was recommended as a means of preserving the population against a further loss in genetic diversity.

Change in genetic size of small-closed populations: Lessons from a domestic mammal population.

Science.gov (United States)

Ghafouri-Kesbi, Farhad

2010-10-01

The aim of this study was to monitor changes in genetic size of a small-closed population of Iranian Zandi sheep, by using pedigree information from animals born between 1991 and 2005. The genetic size was assessed by using measures based on the probability of identity-by-descend of genes (coancestry, f, and effective population size, N(e) ), as well as measures based on probability of gene origin (effective number of founders, f(e) , effective number of founder genomes, f(g) , and effective number of non-founder genomes, f(ne) ). Average coancestry, or the degree of genetic similarity of individuals, increased from 0.81% to 1.44% during the period 1993 to 2005, at the same time that N(e) decreased from 263 to 93. The observed trend for f(e) was irregular throughout the experiment in a way that f(e) was 68, 87, 77, 92, and 80 in 1993, 1996, 1999, 2002, and 2005, respectively. Simultaneously, f(g) , the most informative effective number, decreased from 61 to 35. The index of genetic diversity (GD) which was obtained from estimates of f(g) , decreased about 2% throughout the period studied. In addition, a noticeable reduction was observed in the estimates of f(ne) from 595 in 1993 to 61 in 2005. The higher than 1 ratio of f(e) to f(g) indicated the presence of bottlenecks and genetic drift in the development of this population of Zandi sheep. From 1993 to 1999, f(ne) was much higher than f(e) , thereby indicating that with respect to loss of genetic diversity, the unequal contribution of founders was more important than the random genetic drift in non-founder generations. Subsequently, random genetic drift in non-founder generations was the major reason for f(e) > f(ne) . The minimization of average coancestry in new reproductive individuals was recommended as a means of preserving the population against a further loss in genetic diversity.

Motivaciones, cualidades y valores del empresario fundador colombiano

Directory of Open Access Journals (Sweden)

Ernesto Barrera Duque

2014-01-01

Full Text Available En esta investigación, de carácter cualitativo, se establece una tipología de fundadores empresarios. Emergió de la iteración entre el marco conceptual y el dominio empírico, basado en entrevistas semi-estructuradas. De la integración de una teoría de las motivaciones (extrínsecas, intrínsecas y contributivas con trabajos previos de tipologías en el campo del emprendimiento, se desarrollan tres categorías de fundadores: el “rico”, el “rey” y el “monje”. Esta última es la contribución principal de este artículo. Se postula la hipótesis de que los  fundadores empresarios no se perfilan en los extremos de esta clasificación. Por el contrario, incorporan características de los tres tipos, en diferentes intensidades, y además, pueden cambiar de categoría predominante durante su ciclo de vida. En este artículo también se desarrollan algunas cualidades diferenciales del fundador emprendedor, así como sus valores más importantes.Palabras Clave: Fundador; emprendimiento; motivaciones; valores; Colombia.Colombian founder entrepreneur motivations, qualities and valuesAbstractIn this qualitative type of research is established a typology of business founders. It emerged from the iteration between the conceptual framework and the empirical domain, based on semistructured interviews. From the integration of a theory of motivation (extrinsic, intrinsic and contributory with previous typology works in the field of entrepreneurship, is developed three categories of founders: the “rich”, the “king” and the “Monk”. The latter is the main contribution of this article. It´s proposed the hypothesis that business founders are not outlined in the ends of this classification. Instead, they incorporate features of the three types, at different intensities, and also they may change the predominant category during their life cycle. This article also develops some entrepreneurial founder differential qualities as well as

Psicologia organizacional e do trabalho - retrato da produção científica na última década

Directory of Open Access Journals (Sweden)

Keli Cristina de Lara Campos

Full Text Available As práticas de Psicologia organizacional e do trabalho (POT ocupam um importante espaço no contexto da profissão e justificam a necessidade de esforços investigativos para o conhecimento de seu estado atual. Assim sendo, investigou-se a produção científica nessa área, publicada em periódicos nacionais de 1998 a março de 2009, disponível nas bases de dados Scielo, Pepsic e Lilacs. As palavras-chave utilizadas na pesquisa inicial foram: Psicologia organizacional, Psicologia do trabalho e Psicologia no trabalho, tendo sido selecionados 619 artigos. Após leitura dos resumos, foram identificados 116 artigos que correspondiam à proposta e que foram analisados quanto ao periódico publicado, ao ano de publicação, ao número de autores, à temática e aos tipos de delineamento, estudo, análise e pesquisa. Entre os resultados obtidos, pode-se observar um aumento significativo no número de publicações anuais, sendo que a temática com o maior número de publicações foi trabalho e saúde. É possível afirmar também que a análise delineia o desenvolvimento de uma área e suas especificidades de estudos, ajudando a evidenciar a expansão e a qualidade da produção científica bem como novos campos para investigação.

Relatórios de sustentabilidade segundo a Global Reporting Initiative (GRI: uma análise de correspondências entre os setores econômicos brasileiros

Directory of Open Access Journals (Sweden)

Murilo de Alencar Souza Oliveira

2014-06-01

Full Text Available O presente artigo tem por objetivo principal apresentar o nível de adesão e o volume de publicações dos relatórios de sustentabilidade das empresas brasileiras conforme as diretrizes da Global Reporting Initiative (GRI entre 2000 e 2008. Para a análise, foram definidas 5 variáveis de estudo: i Setor econômico de atuação das empresas; ii Ano de adesão às diretrizes; iii Nível de aplicação das diretrizes; iv Existência de ações negociadas em segmentos da BM&FBOVESPA; e v Participação na composição do índice de sustentabilidade empresarial (ISE da BM&FBOVESPA. Quanto aos procedimentos metodológicos, foram aplicadas análises por correspondências simples e múltipla entre os setores de atuação econômica das empresas publicantes e as 5 variáveis de estudos definidas. Os resultados mostram que o universo de organizações que publicaram relatórios socioambientais até 2008 ainda é reduzido. Contudo, observa-se crescente adesão, demonstrada pelo número de publicações, sobretudo na Europa. As empresas brasileiras responderam por metade do volume de publicações em 2008 na América Latina e o setor de energia liderou esse processo no país com 35% da amostra.

Sprashivajem? Otvetshajem... / Vladimir Evve

Index Scriptorium Estoniae

Evve, Vladimir

2002-01-01

Autor kommenteerib Res Publica reklaamartiklit kohalikeks valimisteks, kus esitati kaks küsimust - mida teha, et me elaksime nagu inimesed ja kes on süüdi, et Kohtla-Järvel on halb? Vt. ka 20. sep. Infopressi

Ponizhenije reitingovogo prognoza Estonii

Index Scriptorium Estoniae

2006-01-01

Isamaa ja Res Publica Liidu kaasesimehe Taavi Veskimäe sõnul näitab Eesti reitinguväljavaate alandamine, et rahvusvaheline reitinguagentuur Standard & Poor's ei usu Eesti valitsuse soovi ja suutlikkusse teha piisavaid jõupingutusi inflatsiooni alandamiseks

Peeter Kreitzberg välistab koostöö reformiparteiga / Toomas Sildam

Index Scriptorium Estoniae

Sildam, Toomas, 1961-

2003-01-01

Peeter Kreitzberg nimetab ERL-i valitsusest lahkumise otsust arusaadavaks. Ta ei välista, et pärast Res Publica ja Reformierakonna vähemusvalitsuse lagunemist moodustub koalitsioon, kuhu võivad kuuluda mis tahes erakonnad, aga mitte Reformierakond

Ühetasandiline omavalitsus maakonna tasandil / Helir-Valdor Seeder

Index Scriptorium Estoniae

Seeder, Helir-Valdor, 1964-

2008-01-01

Ilmunud ka: Eesti Eest = Za Estoniju : Izdanije objedinenija "Sojuz Otetshestva i Res Publica" 15. mai 2008, lk. 6. Maakonnad on vanimad ja kõige optimaalsemad territoriaalse juhtimise üksused Eestis, mille kujunemise aluseks on asustus ja looduslikud tingimused

Mathematical modeling of ultradeep sequencing data reveals that acute CD8+ T-lymphocyte responses exert strong selective pressure in simian immunodeficiency virus-infected macaques but still fail to clear founder epitope sequences.

Science.gov (United States)

Love, Tanzy M T; Thurston, Sally W; Keefer, Michael C; Dewhurst, Stephen; Lee, Ha Youn

2010-06-01

The prominent role of antiviral cytotoxic CD8(+) T-lymphocytes (CD8-TL) in containing the acute viremia of human and simian immunodeficiency viruses (HIV-1 and SIV) has rationalized the development of T-cell-based vaccines. However, the presence of escape mutations in the acute stage of infection has raised a concern that accelerated escape from vaccine-induced CD8-TL responses might undermine vaccine efficacy. We reanalyzed previously published data of 101,822 viral genomes of three CD8-TL epitopes, Nef(103-111)RM9 (RM9), Tat(28-35)SL8 (SL8), and Gag(181-189)CM9 (CM9), sampled by ultradeep pyrosequencing from eight macaques. Multiple epitope variants appeared during the resolution of acute viremia, followed by the predominance of a single mutant epitope. By fitting a mathematical model, we estimated the first acute escape rate as 0.36 day(-1) within escape-prone epitopes, RM9 and SL8, and the chronic escape rate as 0.014 day(-1) within the CM9 epitope. Our estimate of SIV acute escape rates was found to be comparable to very early HIV-1 escape rates. The timing of the first escape was more highly correlated with the timing of the peak CD8-TL response than with the magnitude of the CD8-TL response. The transmitted epitope decayed more than 400 times faster during the acute viral decline stage than predicted by a neutral evolution model. However, the founder epitope persisted as a minor population even at the viral set point; in contrast, the majority of acute escape epitopes were completely cleared. Our results suggest that a reservoir of SIV infection is preferentially formed by virus with the transmitted epitope.

Engagement no trabalho: uma discussão teórica

Directory of Open Access Journals (Sweden)

Paulo Cesar Porto-Martins

2013-12-01

Full Text Available O engagement no trabalho é considerado como um estado cognitivo positivo de realização, relacionado com o mundo laboral, que se caracteriza por três dimensões: vigor, dedicação e absorção. Este é formado por um componente comportamental-energético (vigor, um componente emocional (dedicação e um componente cognitivo (absorção. O objetivo deste estudo é apresentar uma revisão de publicações científicas internacionais acerca do constructo. O estudo do engagement no trabalho vem como consequência de inúmeras pesquisas realizadas sobre a síndrome de burnout, corroborando com as premissas da psicologia positiva. Conclui-se que existe deficiência de publicações neste constructo, principalmente em se tratando do contexto brasileiro.

A fundação de periódicos literários no terceiro quartel do século XIX: em defesa da literatura ou em prol da política e da educação? = La fundación de periódicos literarios en el tercer cuarto del siglo XIX: ¿en defensa de la literatura o a favor de la política y de la educación? = The foundation of literary periodicals in the third quarter of the nineteenth century: literature promotion or a political and educational agenda?

Directory of Open Access Journals (Sweden)

Baleiro, Rita

2013-01-01

Full Text Available O artigo apresenta 8 textos-fundação de periódicos literários portugueses (1855-1865. Pretende estudar as publicações nascidas durante a polémica literária portuguesa – a Questão Coimbr㠖 e, aplicando análise de texto detalhada, analisar: a a linha editorial das publicações; b a relação estabelecida com os leitores; c para que público(s escreviam? A análise regista uma preocupação didática, reflexo do contexto socio-histórico de promoção da instrução pública, quando mais de 70% da população era analfabeta e, em alguns casos, para o estreitamento de relações com o Brasil

O pesquisar em ação

Directory of Open Access Journals (Sweden)

Marcia Moraes

2012-12-01

Full Text Available O objetivo deste texto é fazer uma resenha do livro intitulado Pesquisar na Diferença, uma publicação coletiva, inspirada pelo Abecedário de Gilles Deleuze. O livro é composto por verbetes, cada um dos quais ligados a uma ação que se faz presente no pesquisar, tal como é entendido pelo grupo de pesquisadores que compõe o volume. Observar, desejar, escrever, afetar, tatear são alguns dos verbetes presentes neste livro. Os autores que se reúnem nesta publicação definem a pesquisa como uma ação encarnada e situada, como uma prática de composição de mundo e que por isso mesmo, é eminentemente política. É a partir deste ponto que os verbetes são definidos.

TIPOS DE CARREIRA: ANÁLISE DA PRODUÇÃO CIENTÍFICA

Directory of Open Access Journals (Sweden)

Fernanda Almeida da Silva Rosa

2017-04-01

Full Text Available Esta pesquisa buscou analisar e quantificar as publicações sobre carreira e, dentro destas as que envolviam além do termo carreira a questão do gênero, publicadas no ENANPAD, SEMEAD e Revista RECAPE no período de 2010-2014. Dessa forma, optou-se como processo metodológico a pesquisa bibliométrica e a utilização do programa Ucinet® para tratamento dos dados. Para a pesquisa foram selecionados 76 artigos e após o filtro de citações foram analisados 29 artigos. Os resultados apontaram para uma forte tendência nas pesquisas para os temas voltados para carreira subjetiva (individual e um escasso estudo sobre o tema carreira e gênero. Destacam-se três pesquisadores brasileiros com publicações de artigos sobre o tema carreira.

On the origin and diffusion of BRCA1 c.5266dupC (5382insC) in European populations

DEFF Research Database (Denmark)

Hamel, Nancy; Feng, Bing-Jian; Foretova, Lenka

2011-01-01

The BRCA1 mutation c.5266dupC was originally described as a founder mutation in the Ashkenazi Jewish (AJ) population. However, this mutation is also present at appreciable frequency in several European countries, which raises intriguing questions about the origins of the mutation. We genotyped 245...... carrier families from 14 different population groups (Russian, Latvian, Ukrainian, Czech, Slovak, Polish, Danish, Dutch, French, German, Italian, Greek, Brazilian and AJ) for seven microsatellite markers and confirmed that all mutation carriers share a common haplotype from a single founder individual.......5266dupC originated from a single common ancestor and was a common European mutation long before becoming an AJ founder mutation and (2) the mutation is likely present in many additional European countries where genetic screening of BRCA1 may not yet be common practice....

The promise of discovering population-specific disease-associated genes in South Asia.

Science.gov (United States)

Nakatsuka, Nathan; Moorjani, Priya; Rai, Niraj; Sarkar, Biswanath; Tandon, Arti; Patterson, Nick; Bhavani, Gandham SriLakshmi; Girisha, Katta Mohan; Mustak, Mohammed S; Srinivasan, Sudha; Kaushik, Amit; Vahab, Saadi Abdul; Jagadeesh, Sujatha M; Satyamoorthy, Kapaettu; Singh, Lalji; Reich, David; Thangaraj, Kumarasamy

2017-09-01

The more than 1.5 billion people who live in South Asia are correctly viewed not as a single large population but as many small endogamous groups. We assembled genome-wide data from over 2,800 individuals from over 260 distinct South Asian groups. We identified 81 unique groups, 14 of which had estimated census sizes of more than 1 million, that descend from founder events more extreme than those in Ashkenazi Jews and Finns, both of which have high rates of recessive disease due to founder events. We identified multiple examples of recessive diseases in South Asia that are the result of such founder events. This study highlights an underappreciated opportunity for decreasing disease burden among South Asians through discovery of and testing for recessive disease-associated genes.

Crowdinvesting-an alternative financing for German start-up enterprises?

OpenAIRE

Schütte, Sven

2016-01-01

Creation of young and innovational ventures is becoming more and more attrac-tive for potential business founders, due to beneficial political and economic frame conditions. Nevertheless, the issue of funding the project is concerning most of entrepreneurs: Because relatively weak own financial backings seldom suffice until profitability stage, founders are depending on external financial support in order to cover an arising equity gap. Here, established traditional forms of financing ca...

REFERENCIAL TEÓRICO

Directory of Open Access Journals (Sweden)

Mariana Fernandes de Souza

Full Text Available A autora aborda o conhecimento teórico na enfermagem, focaliza algumas publicações consideradas importantes sobre o mesmo e tece considerações sobre modelos conceituais e teorias como referencial para atuação profissional.

Kas IRL pelgab, et Juku-Kalle Raid kavatsebki riigikokku tulla? / Kärt Anvelt

Index Scriptorium Estoniae

Anvelt, Kärt, 1973-

2011-01-01

2011. aasta parlemendivalimistel Isamaa ja Res Publica Liidu nimekirjas kandideerinud ajalehe KesKus peatoimetaja Juku-Kalle Raid on praeguse majandus- ja kommunikatsiooniministri Juhan Partsi asendusliige ning kui viimane jätkab ministrina, läheb Juku-Kalle Raid tema asemel riigikokku

Mimesis in Bible Didactics – an outline in the context of religious ...

African Journals Online (AJOL)

2015-10-23

Oct 23, 2015 ... How to cite this article: Zimmermann, M. ... are central to the third book of Plato's Res Publica and reveals the .... type of depiction and reference brings it into the present ..... W.H. Fyfe, Harvard University Press, Cambridge, MA/.

Arengufoorumi korraldavad linnapea parteikaaslased / Kadri Jakobson

Index Scriptorium Estoniae

Jakobson, Kadri, 1970-

2005-01-01

Linnaplaneerimise ameti poolt välja kuulutatud riigihanke 2005. aasta septembris toimuva Tallinna linna arengufoorumi korraldamiseks võitis OÜ Hillside Events, mille omanik on Res Publica asutaja Tõnis-Martin Kons. Lisa: Aasta tagasi kritiseeris Palts Savisaart samasuguse käitumise eest

Experiment list: SRX026643 [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available | disease state=leukemic || treatment=no || antibody=AE (A706) || antibody vendor=n/a (commercialization pending... manuscript publication) || antibody catalog number=n/a (commercialization pending manuscript publicatio...n) || antibody lot/batch number=n/a (commercialization pending manuscript publica

Experiment list: SRX026648 [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available | disease state=leukemic || treatment=no || antibody=AE (A706) || antibody vendor=n/a (commercialization pending... manuscript publication) || antibody catalog number=n/a (commercialization pending manuscript publicatio...n) || antibody lot/batch number=n/a (commercialization pending manuscript publica

PR-spetsid annavad Partsile nõu puhata ja analüüsida

Index Scriptorium Estoniae

2005-01-01

TÜ avalikkussuhete õppejõud Kaja Saksakulm-Tampere soovitab Juhan Partsil toimunut analüüsida, suhtekorraldusspetsialist Ivo Rulli arvates oleks Juhan Partsil mõistlik võtta oma edasises avalikus elus pikem paus, taanduda Res Publica esimehe kohalt ja tegutseda parlamendis opositsioonis

Tööandjate Keskliidu pöördumine / Enn Veskimägi

Index Scriptorium Estoniae

Veskimägi, Enn, 1947-

2008-01-01

Ilmunud ka: Eesti Eest = Za Estoniju : Izdanije objedinenija "Sojuz Otetshestva i Res Publica" 15. mai 2008, lk. 3. Eesti Tööandjate Keskliidu Volikogu esimehe pöördumine, milles tehakse ettepanekuid vajalike muutuste tekkeks tänases majandusühiskonnas

Idealismi kaotus / Jarno Laur

Index Scriptorium Estoniae

Laur, Jarno, 1975-

2004-01-01

Ilmunud ka: Koit, 23. nov. 2004, lk. 6; Meie Maa, 25. nov. 2004, lk. 2; Hiiu Leht, 26. nov. 2004, lk. 2; Vooremaa, 27. nov. 2004, lk. 2; Sakala, 30. nov. 2004, lk. 2. Sotsiaaldemokraadist parlamendiliikme kriitika Res Publica aadressil

Maamaksu tõus karistab kodu / Ken-Marti Vaher, Urmas Reinsalu, Margus Tsahkna

Index Scriptorium Estoniae

Vaher, Ken-Marti, 1974-

2008-01-01

Ilmunud ka: Eesti Eest = Za Estoniju : Izdanije objedinenija "Sojuz Otetshestva i Res Publica" 15. mai 2008, lk. 7. Riigikogu liikmed leiavad, et parlament peab rahvast Tallinna kõrge maamaksu eest kaitsma. Vt. samas: Kaia Iva. Maamaks on nagu sundkorras kolhoosi astumine

Facing our Delusions: Rosenzweig’s Defence of Subtlety

Directory of Open Access Journals (Sweden)

Camelia Gradinaru

2011-12-01

Full Text Available Review of: Phil Rosenzweig, Efectul de halou si alte opt iluzii economice care îi induc în eroare pe manageri [The Halo Effect... and the Eight Other Business Delusions that Deceive Managers], Bucuresti: Publica, 2010, 296 p.

Transmitted/founder and chronic subtype C HIV-1 use CD4 and CCR5 receptors with equal efficiency and are not inhibited by blocking the integrin α4β7.

Directory of Open Access Journals (Sweden)

Nicholas F Parrish

Full Text Available Sexual transmission of human immunodeficiency virus type 1 (HIV-1 most often results from productive infection by a single transmitted/founder (T/F virus, indicating a stringent mucosal bottleneck. Understanding the viral traits that overcome this bottleneck could have important implications for HIV-1 vaccine design and other prevention strategies. Most T/F viruses use CCR5 to infect target cells and some encode envelope glycoproteins (Envs that contain fewer potential N-linked glycosylation sites and shorter V1/V2 variable loops than Envs from chronic viruses. Moreover, it has been reported that the gp120 subunits of certain transmitted Envs bind to the gut-homing integrin α4β7, possibly enhancing virus entry and cell-to-cell spread. Here we sought to determine whether subtype C T/F viruses, which are responsible for the majority of new HIV-1 infections worldwide, share biological properties that increase their transmission fitness, including preferential α4β7 engagement. Using single genome amplification, we generated panels of both T/F (n = 20 and chronic (n = 20 Env constructs as well as full-length T/F (n = 6 and chronic (n = 4 infectious molecular clones (IMCs. We found that T/F and chronic control Envs were indistinguishable in the efficiency with which they used CD4 and CCR5. Both groups of Envs also exhibited the same CD4+ T cell subset tropism and showed similar sensitivity to neutralization by CD4 binding site (CD4bs antibodies. Finally, saturating concentrations of anti-α4β7 antibodies failed to inhibit infection and replication of T/F as well as chronic control viruses, although the growth of the tissue culture-adapted strain SF162 was modestly impaired. These results indicate that the population bottleneck associated with mucosal HIV-1 acquisition is not due to the selection of T/F viruses that use α4β7, CD4 or CCR5 more efficiently.