77 FR 20010 - Notice of Public Workshop: “Designing for Impact: Workshop on Building the National Network for...

Science.gov (United States)

2012-04-03

... Polytechnic Institute, Troy, NY, 12180. EMPAC is located at the corner of 8th Street and College Avenue, in Troy, NY. Members of the public wishing to attend the public workshop may register online at: http...

Impact of After-School Nutrition Workshops in a Public Library Setting

Science.gov (United States)

Freedman, Marjorie R.; Nickell, Audrey

2010-01-01

Objective: To determine if after-school nutrition workshops conducted in public libraries were related to lasting changes in food choice. Methods: "Snack Smart" workshops, based on Social Cognitive Theory, were conducted in 8 branch libraries (49 ethnically diverse children, ages 9 to 14) to assess changes in consumption of targeted food items by…

76 FR 49776 - The Development and Evaluation of Next-Generation Smallpox Vaccines; Public Workshop

Science.gov (United States)

2011-08-11

...] The Development and Evaluation of Next-Generation Smallpox Vaccines; Public Workshop AGENCY: Food and... Evaluation of Next-Generation Smallpox Vaccines.'' The purpose of the public workshop is to identify and discuss the key issues related to the development and evaluation of next-generation smallpox vaccines. The...

76 FR 45271 - Review and Qualification of Clinical Outcome Assessments; Public Workshop

Science.gov (United States)

2011-07-28

... announcing a public workshop to discuss measurement principles for clinical outcome assessments (COAs) for... appropriate drug development program. Because the qualification process is separate from the drug marketing... other DDTs. This workshop will focus on FDA review principles specific to all type of COAs, i.e., PRO...

76 FR 51041 - Hemoglobin Standards and Maintaining Adequate Iron Stores in Blood Donors; Public Workshop

Science.gov (United States)

2011-08-17

...] Hemoglobin Standards and Maintaining Adequate Iron Stores in Blood Donors; Public Workshop AGENCY: Food and... Donors.'' The purpose of this public workshop is to discuss blood donor hemoglobin and hematocrit qualification standards in the United States, its impact on donor safety and blood availability, and potential...

78 FR 32010 - Pipeline Safety: Public Workshop on Integrity Verification Process

Science.gov (United States)

2013-05-28

... DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration [Docket No... Hazardous Materials Safety Administration, DOT. ACTION: Notice of public meeting. SUMMARY: This notice is announcing a public workshop to be held on the concept of ``Integrity Verification Process.'' The Integrity...

76 FR 45268 - Center for Drug Evaluation and Research, Approach to Addressing Drug Shortage; Public Workshop

Science.gov (United States)

2011-07-28

...] Center for Drug Evaluation and Research, Approach to Addressing Drug Shortage; Public Workshop AGENCY... Administration (FDA) is announcing a public workshop regarding the approach of the Center for Drug Evaluation and..., and to gain additional insight from, professional societies, patient advocates, industry, consumer...

78 FR 10181 - Global Quality Systems-An Integrated Approach To Improving Medical Product Safety; Public Workshop

Science.gov (United States)

2013-02-13

...] Global Quality Systems--An Integrated Approach To Improving Medical Product Safety; Public Workshop... (AFDO), is announcing a public workshop entitled ``Global Quality Systems--An Integrated Approach to... topics concerning FDA requirements related to the production and marketing of drugs and/or devices...

Natural resource workshop: Public/private partnership for sustainable use of natural resources

Energy Technology Data Exchange (ETDEWEB)

NONE

1995-07-01

As part of an effort to shape Federal policy for environmentally sound, sustainable economic development, the White House Office of Science and Technology Policy sponsored a workshop in Boise, Idaho on February 1--2, 1995. The Boise Idaho workshop focused on the sustainable use of natural resources, a topic of considerable interest in Idaho. The workshop gave representatives from industry, academia, research, the public, and local and state government an opportunity to provide input to lawmakers and policymakers for establishing a National Environmental Technology Strategy to be issued by Earth Day, 1995.

Game-Coding Workshops in New Zealand Public Libraries: Evaluation of a Pilot Project

Science.gov (United States)

Bolstad, Rachel

2016-01-01

This report evaluates a game coding workshop offered to young people and adults in seven public libraries round New Zealand. Participants were taken step by step through the process of creating their own simple 2D videogame, learning the basics of coding, computational thinking, and digital game design. The workshops were free and drew 426 people…

ITS standards : lessons learned from deployment : raising ITS standards IQ with a public sector workshop

Science.gov (United States)

2000-01-01

This document contains information about a Public Sector Workshop held in Minnesota that focused on increasing the awareness of Intelligent Transportation Systems (ITS) standards. It gives an overview of how the workshop proceeded, which topics were ...

ENVIRONMENTAL PUBLIC HEALTH OUTCOMES WORKSHOP PROCEEDINGS -RESEARCH TRIANGLE PARK, NC, 7/30-31/2002

Science.gov (United States)

To better define ORD's Environmental Public Health Outcomes (EPHO) research agenda, a workshop was held 7/30-31/2002 at EPA facilities in Research Triangle Park, NC. The intent of this workshop was to engage federal and other organizations in a dialog that will assist ORD in deve...

Report on the NRA workshop ''investing in trust, nuclear regulators and the public''

International Nuclear Information System (INIS)

Laaksonen, J.

2002-01-01

The workshop was held in Paris on the 29. November - 1. December 2000. Its objective was well captured in the title: Investing in Trust, Nuclear Regulators and the Public. The general public is concerned with the risks involved in the use of nuclear power, and has a legitimate desire for reliable and impartial information. The nuclear regulators have answers, but in order to fulfill the information needs of the general public and their elected representatives, they need to be regarded trustworthy. Most of the about 80 participants were from nuclear regulatory bodies and radiation protection agencies. The discussions gave regulators an opportunity to change views and experiences on how to gain trust in their openness and honesty, and in their will and capability to protect public interests. The weight given to the topic was indicated by participation of nine heads of national regulatory bodies, among them top regulators from four countries with largest nuclear programmes: the USA, Japan, France, and the UK. The number of papers presented was 33, and their topics were considered well chosen by the organizing committee. Throughout the workshop 'posters' were available; these were electronic links to the web sites of the attending regulatory bodies. Proceedings of the workshop will be published during the first half of 2001. (author)

78 FR 30964 - Pipeline Safety: Workshop on Public Awareness Programs

Science.gov (United States)

2013-05-23

... Richardson, Texas. The workshop serves as an opportunity to bring pipeline safety stakeholders together to..., and excavators) will share their perspectives on what is working and what is not working with existing... discuss recent inspection findings; (2) Understand what's working and not working with public awareness...

Writing for publication in medical education: the benefits of a faculty development workshop and peer writing group.

Science.gov (United States)

Steinert, Yvonne; McLeod, Peter J; Liben, Stephen; Snell, Linda

2008-01-01

Although educational innovations in medical education are increasing in number, many educators do not submit their ideas for publication. The goal of this initiative was to assist faculty members write about their educational innovations. Twenty-four faculty members participated in this intervention, which consisted of a half-day workshop, three peer writing groups, and independent study. We assessed the impact of this intervention through post-workshop evaluations, a one-year follow-up questionnaire, tracking of manuscript submissions, and an analysis of curriculum vitae. The workshop evaluations and one-year follow-up demonstrated that participants valued the workshop small groups, self-instructional workbook, and peer support and feedback provided by the peer writing groups. One year later, nine participants submitted a total of 14 manuscripts, 11 of which were accepted for publication. In addition, 10 participants presented a total of 38 abstracts at educational meetings. Five years later, we reviewed the curriculum vitae of all participants who had published or presented their educational innovation. Although the total number of publications remained the same, the number of educationally-related publications and presentations at scientific meetings increased considerably. A faculty development workshop and peer writing group can facilitate writing productivity and presentations of scholarly work in medical education.

76 FR 67463 - Pediatric Medical Devices; Public Workshop; Request for Comments

Science.gov (United States)

2011-11-01

... use, existing scientific research data to determine pediatric effectiveness based on a similar course... research data, and C. The methods to overcome the pitfalls and data gaps, including statistical approaches... announcing a public workshop entitled ``Using Scientific Research Data to Support Pediatric Medical Device...

[Towards a social determinants-oriented approach to public health: workshop report].

Science.gov (United States)

Rojo, Elena González; Álvarez-Dardet, Carlos; Fernández, Luis Andrés López

2017-12-01

This article is the result of a workshop with public health experts held in Granada (Spain) in October 2015 in order to reflect upon the components of the framework that should be part of a public health approach based on the social determinants of health. Advocacy and training professionals in health advocacy were identified as key elements where this was needed. During the workshop, it was agreed that the gender perspective, the salutogenic approach, interdisciplinary work and particular attention to disadvantaged groups are crucial. The importance of working from a human rights' framework and promoting legislative changes were also mentioned. Moreover, the group mentioned that even though much progress has been made identifying social determinants of health and creating conceptual frameworks, there is limited knowledge about how to intervene to reduce health inequality gaps in our societies. Copyright © 2017 SESPAS. Publicado por Elsevier España, S.L.U. All rights reserved.

Impact of after-school nutrition workshops in a public library setting.

Science.gov (United States)

Freedman, Marjorie R; Nickell, Audrey

2010-01-01

To determine if after-school nutrition workshops conducted in public libraries were related to lasting changes in food choice. "Snack Smart" workshops, based on Social Cognitive Theory, were conducted in 8 branch libraries (49 ethnically diverse children, ages 9 to 14) to assess changes in consumption of targeted food items by pretest, posttest, and follow-up food frequency questionnaires. Results were analyzed using the Friedman test for repeated measures and Wilcoxon signed rank test. Intake of milk, vegetables, and water significantly increased at 3-week posttest (P school nutrition programs for lasting impact. Copyright 2010 Society for Nutrition Education. Published by Elsevier Inc. All rights reserved.

76 FR 10810 - Public Workshop to Discuss Low-Level Radioactive Waste Management

Science.gov (United States)

2011-02-28

... Radioactive Waste Management AGENCY: Nuclear Regulatory Commission. ACTION: Public Workshop and Request for... regulatory framework for the management of commercial low-level radioactive waste (LLW). The purpose of this...-level radioactive wastes that did not exist at the time part 61 was promulgated. The developments...

78 FR 49530 - Gastroenterology Regulatory Endpoints and the Advancement of Therapeutics; Public Workshop

Science.gov (United States)

2013-08-14

...] Gastroenterology Regulatory Endpoints and the Advancement of Therapeutics; Public Workshop AGENCY: Food and Drug... for Drug Evaluation and Research, in cosponsorship with the American College of Gastroenterology, the... American Society for Pediatric Gastroenterology, Hepatology, and Nutrition, and the Pediatric IBD...

Summary of Information Presented at an NRC-Sponsored Low-Power Shutdown Public Workshop, April 27, 1999, Rockville, Maryland

International Nuclear Information System (INIS)

Wheeler, Timothy A.; Whitehead, Donnie W.; Lois, Erasmia

1999-01-01

This report summarizes a public workshop that was held on April 27, 1999, in Rockville, Maryland. The workshop was conducted as part of the US Nuclear Regulatory Commission's (NRC) efforts to further develop its understanding of the risks associated with low power and shutdown operations at US nuclear power plants. A sufficient understanding of such risks is required to support decision-making for risk-informed regulation, in particular Regulatory Guide 1.174, and the development of a consensus standard. During the workshop the NRC staff discussed and requested feedback from the public (including representatives of the nuclear industry, state governments, consultants, private industry, and the media) on the risk associated with low-power and shutdown operations

Summary of Information Presented at an NRC-Sponsored Low-Power Shutdown Public Workshop, April 27, 1999, Rockville, Maryland

Energy Technology Data Exchange (ETDEWEB)

Wheeler, Timothy A.; Whitehead, Donnie W.; Lois, Erasmia

1999-07-01

This report summarizes a public workshop that was held on April 27, 1999, in Rockville, Maryland. The workshop was conducted as part of the US Nuclear Regulatory Commission's (NRC) efforts to further develop its understanding of the risks associated with low power and shutdown operations at US nuclear power plants. A sufficient understanding of such risks is required to support decision-making for risk-informed regulation, in particular Regulatory Guide 1.174, and the development of a consensus standard. During the workshop the NRC staff discussed and requested feedback from the public (including representatives of the nuclear industry, state governments, consultants, private industry, and the media) on the risk associated with low-power and shutdown operations.

Workshop salutogenesis and the future of health promotion and public health.

Science.gov (United States)

Lindström, Bengt

2018-02-01

This presentation is a synthesis of a workshop on Salutogenesis and the Future of Health Promotion and Public Health at the Nordic Health Promotion Research Conference in June 2016. A brief historical review of Public Health and Health Promotion development in a Nordic perspective is included. However, the main thrust of the article is to present how the salutogenic theory and approach could strengthen society's organised efforts to prevent disease, promote health and prolong life. A critical view based on existing evidence is maintained through the presentation that arrives at the conclusion it would be worthwhile to invest in effective theory driven approaches to the development of Public Health and Health Promotion in the future.

76 FR 81929 - South Carolina Public Service Authority; Notice of Workshop for Santee Cooper Hydroelectric Project

Science.gov (United States)

2011-12-29

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Project No. 199-205] South Carolina Public Service Authority; Notice of Workshop for Santee Cooper Hydroelectric Project On May 26 and...) and the South Carolina Public Service Authority (SCPSA), licensee for the Santee-Cooper Hydroelectric...

Eliciting Public Attitudes Regarding Bioremediation Cleanup Technologies: Lessons Learned from a Consensus Workshop in Idaho

Energy Technology Data Exchange (ETDEWEB)

Denise Lach, Principle Investigator; Stephanie Sanford, Co-P.I.

2003-03-01

During the summer of 2002, we developed and implemented a ''consensus workshop'' with Idaho citizens to elicit their concerns and issues regarding the use of bioremediation as a cleanup technology for radioactive nuclides and heavy metals at Department of Energy (DOE) sites. The consensus workshop is a derivation of a technology assessment method designed to ensure dialogue between experts and lay people. It has its origins in the United States in the form of ''consensus development conferences'' used by the National Institutes of Health (NIH) to elicit professional knowledge and concerns about new medical treatments. Over the last 25 years, NIH has conducted over 100 consensus development conferences. (Jorgensen 1995). The consensus conference is grounded in the idea that technology assessment and policy needs to be socially negotiated among many different stakeholders and groups rather than narrowly defined by a group of experts. To successfully implement new technology, the public requires access to information that addresses a full complement of issues including understanding the organization proposing the technology. The consensus conference method creates an informed dialogue, making technology understandable to the general public and sets it within perspectives and priorities that may differ radically from those of the expert community. While specific outcomes differ depending on the overall context of a conference, one expected outcome is that citizen panel members develop greater knowledge of the technology during the conference process and, sometimes, the entire panel experiences a change in attitude toward the technology and/or the organization proposing its use (Kluver 1995). The purpose of this research project was to explore the efficacy of the consensus conference model as a way to elicit the input of the general public about bioremediation of radionuclides and heavy metals at Department of Energy sites

Eliciting Public Attitudes Regarding Bioremediation Cleanup Technologies: Lessons Learned from a Consensus Workshop in Idaho

International Nuclear Information System (INIS)

Denise Lach, Principle Investigator; Stephanie Sanford, Co-P.I.

2003-01-01

During the summer of 2002, we developed and implemented a ''consensus workshop'' with Idaho citizens to elicit their concerns and issues regarding the use of bioremediation as a cleanup technology for radioactive nuclides and heavy metals at Department of Energy (DOE) sites. The consensus workshop is a derivation of a technology assessment method designed to ensure dialogue between experts and lay people. It has its origins in the United States in the form of ''consensus development conferences'' used by the National Institutes of Health (NIH) to elicit professional knowledge and concerns about new medical treatments. Over the last 25 years, NIH has conducted over 100 consensus development conferences. (Jorgensen 1995). The consensus conference is grounded in the idea that technology assessment and policy needs to be socially negotiated among many different stakeholders and groups rather than narrowly defined by a group of experts. To successfully implement new technology, the public requires access to information that addresses a full complement of issues including understanding the organization proposing the technology. The consensus conference method creates an informed dialogue, making technology understandable to the general public and sets it within perspectives and priorities that may differ radically from those of the expert community. While specific outcomes differ depending on the overall context of a conference, one expected outcome is that citizen panel members develop greater knowledge of the technology during the conference process and, sometimes, the entire panel experiences a change in attitude toward the technology and/or the organization proposing its use (Kluver 1995). The purpose of this research project was to explore the efficacy of the consensus conference model as a way to elicit the input of the general public about bioremediation of radionuclides and heavy metals at Department of Energy sites. Objectives of the research included: (1

Low and intermediate level waste repositories: Socioeconomic aspects and public involvement. Proceedings of a workshop

International Nuclear Information System (INIS)

2007-06-01

Waste management facilities are needed to protect the environment and improve public health for the long term future. One significant challenge is to inform the public on the relative hazards of radioactive waste compared to other hazards in our modern society and to get the acceptance of the appropriate members of the public for these necessary facilities. Over the entire life cycle of these facilities, the projects must be managed without expending a disproportionate share of the collective resources. Public involvement plays a key role and the sophisticated and extensive public education systems that exist provide a vital service to gain public acceptance. There is a full range of compensation and benefit programmes used as incentives for hosting a LILW facility. Even if exemptions exist the experience in most countries indicate the direct/indirect incentives as a necessary part of gaining public acceptance. The countries, regions and local communities have their own established processes to make public decisions. Each organization developing a site must select and implement the methods that are acceptable within their framework of laws and regulations. A three day workshop on socio-economic issues and public involvement practices and approaches for developing and operating repositories for low and intermediate level waste took place in the IAEA headquarters on 9-11 November 2005. The workshop provided a forum where experts from Member States shared their experiences in non-technical aspects of planning, licensing and operating LILW disposal facilities. Description of both principles and practices applied in particular countries provides a useful overview of potential approaches in application of non-technical issues during a repository lifecycle. Participants presented approaches and practices applied in their countries, established new contacts and were able to take advantage of activities and experiences from abroad. There were 25 interesting presentations

75 FR 51829 - Public Workshop on Medical Devices and Nanotechnology: Manufacturing, Characterization, and...

Science.gov (United States)

2010-08-23

... hotel at 301-977-8900 or refer to their Web page at: www.gaithersburg.hilton.com . Contact Person: Daya... provide public comments, time permitting. If you need special accommodations due to a disability, please... refer to the meeting registration Web page at http://www.fda.gov/MedicalDevices/NewsEvents/Workshops...

78 FR 15371 - Drug Development for Chronic Fatigue Syndrome and Myalgic Encephalomyelitis; Public Workshop

Science.gov (United States)

2013-03-11

... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2012-N-0962] Drug Development for Chronic Fatigue Syndrome and Myalgic Encephalomyelitis; Public Workshop AGENCY... therapies to treat signs and symptoms related to chronic fatigue syndrome (CFS) and myalgic...

Algal bloom detection, monitoring and prediction. 3. Workshop on public health

Energy Technology Data Exchange (ETDEWEB)

Catena, G; Funari, E [eds.; Istituto Superiore di Sanita' , Rome (Italy). Lab. di Igiene Ambientale

1999-07-01

The report presents articles discussed in the 3. Workshop on Public Health (Rome, Italy) focused on the problem of the harmful algae in the Mediterranean basin with the aim of verifying the possibilities of using remote sensing techniques together with conventional ones. These proceedings report the aim aspects of the problem, as the ecological one, the conventional monitoring techniques, the activities of international organizations and finally some of the current research activities in Italy aimed at using remote sensing techniques. [Italian] Il workshop sulla salute pubblica e' incentrato sul problema delle alghe tossiche marine all'interno del bacino del Mediterraneo con lo scopo di verificare le possibilita' di utilizzare delle tecniche di telerilevamento in modo complementare rispetto a quelle convenzionali. Si affrontano alcuni degli aspetti principali di questa problematica quali l'ecologia, le tecniche convenzionali di monitoraggio, le attivita' di organismi internazionali e infine le attivita' in corso in Italia finalizzate all'utilizzazione delle tecniche di telerilevamento.

Algal bloom detection, monitoring and prediction. 3. Workshop on public health

Energy Technology Data Exchange (ETDEWEB)

Catena, G.; Funari, E. [eds.] [Istituto Superiore di Sanita' , Rome (Italy). Lab. di Igiene Ambientale

1999-07-01

The report presents articles discussed in the 3. Workshop on Public Health (Rome, Italy) focused on the problem of the harmful algae in the Mediterranean basin with the aim of verifying the possibilities of using remote sensing techniques together with conventional ones. These proceedings report the aim aspects of the problem, as the ecological one, the conventional monitoring techniques, the activities of international organizations and finally some of the current research activities in Italy aimed at using remote sensing techniques. [Italian] Il workshop sulla salute pubblica e' incentrato sul problema delle alghe tossiche marine all'interno del bacino del Mediterraneo con lo scopo di verificare le possibilita' di utilizzare delle tecniche di telerilevamento in modo complementare rispetto a quelle convenzionali. Si affrontano alcuni degli aspetti principali di questa problematica quali l'ecologia, le tecniche convenzionali di monitoraggio, le attivita' di organismi internazionali e infine le attivita' in corso in Italia finalizzate all'utilizzazione delle tecniche di telerilevamento.

Proceedings of the 2010 Canadian Dam Association's public safety around dams workshop

Energy Technology Data Exchange (ETDEWEB)

NONE

2010-07-01

Nearly 30 people have drowned in dam-related incidents over the last 10 years in Canada. The Canadian public is now calling for improved safety guidelines. Public interaction with dams is increasing as a result of interest in extreme sports and perceived rights of access. However, many members of the public are not aware of the dangers posed by dams. This workshop provided a forum to discuss proposals for a draft publication of the Canadian Dam Association (CDA) guidelines for public safety and security around dams. Issues related to current legislation and liability were discussed. Methods of increasing public awareness of the hazards posed by dams included increased signage in dam locations, the use of audible and visual alert systems, and the use of booms and buoys. The responsibilities of dam owners in ensuring the safety of dams were also discussed. The conference featured 5 presentations, of which 2 have been catalogued separately for inclusion in this database. tabs., figs.

Summer workshops for high-school science teachers

International Nuclear Information System (INIS)

Young, H.H.; Kohl, J.

1975-01-01

A total of 52 summer workshops attended by over 1700 high-school science teachers have been given by 27 universities in the period of 1971 to 1974. These workshops are funded by ERDA to provide factual material through educational channels so that the public could obtain an informed perspective of the role of nuclear energy as an electrical power source. The workshops have included lectures, panel discussions, laboratories, and field trips, and have emphasized providing teachers with materials for use in their classrooms. Actual use of workshop material has been monitored through workshop reports, meetings, and visits. Participants have used their workshop experience for classroom presentations, talks to the public, and for assembly programs. The material developed and the experience of presenting it has proved valuable for the nuclear engineering faculty members giving the workshops. They have used their experience in other courses, for public lectures, and for other workshops. And they have gained personal experience in methods of dealing with the nuclear power controversy. A review of these workshops indicates that they offer at a reasonable cost a productive method of presenting factual information on the various solutions to the complex electrical generation problem

Boiling water reactor simulator. Workshop material

International Nuclear Information System (INIS)

2003-01-01

The International Atomic Energy Agency (IAEA) has established an activity in nuclear reactor simulation computer programs to assist its Member States in education. The objective is to provide, for a variety of advanced reactor types, insight and practice in their operational characteristics and their response to perturbations and accident situations. To achieve this, the IAEA arranges for the development and distribution of simulation programs and workshop material and sponsors workshops. The workshops are in two parts: techniques and tools for reactor simulator development; and the use of reactor simulators in education. Workshop material for the first part is covered in the IAEA publication: Training Course Series No. 12, 'Reactor Simulator Development' (2001). Course material for workshops using a WWER- 1000 simulator from the Moscow Engineering and Physics Institute, Russian Federation is presented in the IAEA publication: Training Course Series No. 21 'WWER-1000 Reactor Simulator' (2002). Course material for workshops using a pressurized water reactor (PWR) simulator developed by Cassiopeia Technologies Incorporated, Canada, is presented in the IAEA publication: Training Course Series No. 22 'Pressurized Water Reactor Simulator' (2003). This report consists of course material for workshops using a boiling water reactor (BWR) simulator. Cassiopeia Technologies Incorporated, developed the simulator and prepared this report for the IAEA

Predictive markers of safety and immunogenicity of adjuvanted vaccines.

Science.gov (United States)

Mastelic, Beatris; Garçon, Nathalie; Del Giudice, Giuseppe; Golding, Hana; Gruber, Marion; Neels, Pieter; Fritzell, Bernard

2013-11-01

Vaccination represents one of the greatest public health triumphs; in part due to the effect of adjuvants that have been included in vaccine preparations to boost the immune responses through different mechanisms. Although a variety of novel adjuvants have been under development, only a limited number have been approved by regulatory authorities for human vaccines. This report reflects the conclusions of a group of scientists from academia, regulatory agencies and industry who attended a conference on the current state of the art in the adjuvant field. Held at the U.S. Pharmacopeial Convention (USP) in Rockville, Maryland, USA, from 18 to 19 April 2013 and organized by the International Association for Biologicals (IABS), the conference focused particularly on the future development of effective adjuvants and adjuvanted vaccines and on overcoming major hurdles, such as safety and immunogenicity assessment, as well as regulatory scrutiny. More information on the conference output can be found on the IABS website, http://www.iabs.org/. Copyright © 2013. Published by Elsevier Ltd.. All rights reserved.

Facilitated workshop method to involve stakeholders and public in decision making process in radiological emergencies

International Nuclear Information System (INIS)

Mustonen, Raimo; Sinkko, Kari; Haemaelaeinen, Raimo P.

2006-01-01

International organisations in radiation protection have for many years recommended that key players, e.g. authorities, expert organisations, industry, producers of foodstuffs and even the public, should be involved in the planning of protective actions in case of a nuclear accident. In this work, we have developed and tested a facilitated workshop method where representatives from various fields of the society aim to identify and evaluate systematically protective actions. Decision analysis techniques have been applied in workshops in order to find out the most feasible countermeasure strategies and to make the decision making-process transparent and auditable. The work builds on case studies where it was assumed that a hypothetical accident had led to a release of considerable amounts of radionuclides and therefore various types of countermeasures should be considered. This paper provides experiences gained in several European countries on how to facilitate this kind of workshops and how modern decision analysis techniques can be applied in the decision-making process

Facilitated workshop method to involve stakeholders and public in decision making process in radiological emergencies

Energy Technology Data Exchange (ETDEWEB)

Mustonen, Raimo; Sinkko, Kari [STUK-Radiation and Nuclear Safety Authority, Helsinki (Finland). Research and Environmental Surveillance; Haemaelaeinen, Raimo P. [Helsinki Univ. of Technology, Helsinki (Finland). System Analysis Laboratory

2006-09-15

International organisations in radiation protection have for many years recommended that key players, e.g. authorities, expert organisations, industry, producers of foodstuffs and even the public, should be involved in the planning of protective actions in case of a nuclear accident. In this work, we have developed and tested a facilitated workshop method where representatives from various fields of the society aim to identify and evaluate systematically protective actions. Decision analysis techniques have been applied in workshops in order to find out the most feasible countermeasure strategies and to make the decision making-process transparent and auditable. The work builds on case studies where it was assumed that a hypothetical accident had led to a release of considerable amounts of radionuclides and therefore various types of countermeasures should be considered. This paper provides experiences gained in several European countries on how to facilitate this kind of workshops and how modern decision analysis techniques can be applied in the decision-making process.

78 FR 58311 - Complex Issues in Developing Drug and Biological Products for Rare Diseases; Public Workshop...

Science.gov (United States)

2013-09-23

... public workshop must register online by December 20, 2013. Early registration is recommended because...; however, it does not alter the statutory standards for marketing approval. To gain approval, all drugs must demonstrate substantial evidence of effectiveness, safety, and product quality for the treatment...

Summary of comments received at workshop on use of a Site Specific Advisory Board (SSAB) to facilitate public participation in decommissioning cases

International Nuclear Information System (INIS)

Caplin, J.; Padge, G.; Smith, D.; Wiblin, C.

1995-06-01

The Nuclear Regulatory Commission (NRC) is conducting an enhanced participatory rulemaking to establish radiological criteria for the decommissioning of NRC-licensed facilities. As part of this rulemaking, On August 20, 1994 the NRC published a proposed rule for public comment. Paragraph 20.1406(b) of the proposed rule would require that the licensee convene a Site Specific Advisory Board (SSAB) if the licensee proposed release of the site for restricted use after decommissioning. To encourage comment the NRC held a workshop on the subject of $SABs on December 6, 7, and 8, 1994. This report summarizes the 567 comments categorized from the transcript of the workshop. The commenters at the workshop generally supported public participation in decommissioning cases. Many participants favored promulgating requirements in the NRC's rules. Some industry participants favored relying on voluntary exchanges between the public and the licensees. Many participants indicated that a SSAB or something functionally equivalent is needed in controversial decommissioning cases, but that some lesser undertaking can achieve meaningful public participation in other cases. No analysis or response to the comments is included in this report

Accelerating energy efficiency improvement in the public sector, using Energy Performance Contracting - a workshop on Nordic experiences and needs for improvements

Energy Technology Data Exchange (ETDEWEB)

Gottberg, Annika; Gode, Jenny; Axelsson, Ulrik

2009-08-15

This report provides documentation on a workshop on experiences of Energy Performance Contracting (EPC) in the Nordic countries, aiming to identify strengths, weaknesses and needs for improvements. The results of surveys undertaken to inform presentations and discussions at the workshop are reported. Furthermore, the outcomes of the discussions during the workshop and resulting recommend actions for different actors to further and accelerate the use of EPC in the public sector are reported. Target groups for this documentation are existing and potential EPC customers, providers and policy-makers

Adjuvant bisphosphonates in early breast cancer

DEFF Research Database (Denmark)

Hadji, P; Coleman, R E; Wilson, C

2016-01-01

Bisphosphonates have been studied in randomised trials in early breast cancer to investigate their ability to prevent cancer treatment-induced bone loss (CTIBL) and reduce the risk of disease recurrence and metastasis. Treatment benefits have been reported but bisphosphonates do not currently have...... regulatory approval for either of these potential indications. This consensus paper provides a review of the evidence and offers guidance to breast cancer clinicians on the use of bisphosphonates in early breast cancer. Using the nominal group methodology for consensus, a systematic review of the literature...... was augmented by a workshop held in October 2014 for breast cancer and bone specialists to present and debate the available pre-clinical and clinical evidence for the use of adjuvant bisphosphonates. This was followed by a questionnaire to all members of the writing committee to identify areas of consensus...

Implementation Strategies for Gender-Sensitive Public Health Practice: A European Workshop.

Science.gov (United States)

Oertelt-Prigione, Sabine; Dalibert, Lucie; Verdonk, Petra; Stutz, Elisabeth Zemp; Klinge, Ineke

2017-11-01

Providing a robust scientific background for the focus on gender-sensitive public health and a systematic approach to its implementation. Within the FP7-EUGenMed project ( http://eugenmed.eu ) a workshop on sex and gender in public health was convened on February 2-3, 2015. The experts participated in moderated discussion rounds to (1) assemble available knowledge and (2) identify structural influences on practice implementation. The findings were summarized and analyzed in iterative rounds to define overarching strategies and principles. The participants discussed the rationale for implementing gender-sensitive public health and identified priorities and key stakeholders to engage in the process. Communication strategies and specific promotion strategies with distinct stakeholders were defined. A comprehensive list of gender-sensitive practices was established using the recently published taxonomy of the Expert Recommendations for Implementing Change (ERIC) project as a blueprint. A clearly defined implementation strategy should be mandated for all new projects in the field of gender-sensitive public health. Our tool can support researchers and practitioners with the analysis of current and past research as well as with the planning of new projects.

Enabling a Secure Environment for Vehicle-to-Vehicle (V2V) and Vehicle-to-Infrastructure (V2I) Transactions : April 2012 Public Workshop Proceedings

Science.gov (United States)

2012-06-08

This report provides a summary and overview of the Public Workshop entitled, Enabling a Secure Environment for Vehicle-to-Vehicle and Vehicle-to-Infrastructure Transactions, presented by USDOT. The workshop took place on April 19-20, 2012 at th...

76 FR 71348 - Role of Naloxone in Opioid Overdose Fatality Prevention; Public Workshop; Request for Comments

Science.gov (United States)

2011-11-17

... discussion about the potential value of making naloxone more widely available outside of conventional medical... registration on the day of the public workshop will be based on space availability. If registration reaches..., is an injectable medicine that can rapidly reverse the overdose of either prescription (e.g., Oxy...

Evaluation of the Geothermal Public Power Utility Workshops in California

Energy Technology Data Exchange (ETDEWEB)

Farhar, B. C.

2004-10-01

The federal government devotes significant resources to educating consumers and businesses about geothermal energy. Yet little evidence exists for defining the kinds of information needed by the various audiences with specialized needs. This paper presents the results of an evaluation of the Geothermal Municipal Utility Workshops that presented information on geothermal energy to utility resource planners at customer-owned utilities in California. The workshops were sponsored by the Western Area Power Administration and the U.S. Department of Energy's GeoPowering the West Program and were intended to qualitatively assess the information needs of municipal utilities relative to geothermal energy and get feedback for future workshops. The utility workshop participants found the geothermal workshops to be useful and effective for their purposes. An important insight from the workshops is that utilities need considerable lead-time to plan a geothermal project. They need to know whether it is better to own a project or to purchase geothermal electricity from another nonutility owner. California customer-owned utilities say they do not need to generate more electricity to meet demand, but they do need to provide more electricity from renewable resources to meet the requirements of the state's Renewable Portfolio Standard.

77 FR 26509 - Notice of Public Meeting-Cloud Computing Forum & Workshop V

Science.gov (United States)

2012-05-04

...--Cloud Computing Forum & Workshop V AGENCY: National Institute of Standards & Technology (NIST), Commerce. ACTION: Notice. SUMMARY: NIST announces the Cloud Computing Forum & Workshop V to be held on Tuesday... workshop. This workshop will provide information on the U.S. Government (USG) Cloud Computing Technology...

Adjuvant vaginal brachytherapy as a part of management in early endometrial cancer.

Science.gov (United States)

Kellas-Ślęczka, Sylwia; Wojcieszek, Piotr; Białas, Brygida

2012-12-01

Endometrial cancer is the most frequent cancer of female genital tract. Metro- and menorrhagia or postmenopausal bleeding results in its early presentation. It allows radical treatment. However, controversies remain on surgery coverage or adjuvant therapies in early endometrial women cancer. Optimal management should minimize intervention instead of aggressive approach, as showed by recent studies. There is a role for brachytherapy as an adjuvant irradiation. Crucial publications including PORTEC-1, GOG 99, MRC ASTEC, ASTEC/EN.5, PORTEC-2 or Italian lymphadenectomy trial are discussed. Moreover, there is attention paid on adjuvant vaginal brachytherapy analyses for the past fifteen years.

Strengthening public health nutrition research and training capacities in West Africa: Report of a planning workshop convened in Dakar, Senegal, 26-28 March 2009.

Science.gov (United States)

Brown, Kenneth H; McLachlan, Milla; Cardosa, Placido; Tchibindat, Félicité; Baker, Shawn K

2010-01-01

A three-day workshop was convened in Dakar, Senegal, to provide participants from West African and international academic and research institutions, public health agencies, and donor organisations an opportunity to review current public health nutrition research and training capabilities in West Africa, assess needs for strengthening the regional institutional and workforce capacities, and discuss appropriate steps required to advance this agenda. The workshop included presentations of background papers, experiences of regional and international training programmes and small group discussions. Participants concluded that there is an urgent need to: (1) increase the throughput of public health nutrition training programmes, including undergraduate education, pre-service and in-service professional training, and higher education in public health nutrition and related research skills; and (2) enhance applied research capacity, to provide the evidence base necessary for nutrition program planning and evaluation. A Task Team was appointed to inform the regional Assembly of Health Ministers of the workshop conclusions and to develop political and financial support for a regional nutrition initiative to: (1) conduct advocacy and nutrition stewardship; (2) survey existing training programmes and assist with curriculum development; and (3) develop a plan for a regional applied research institute in Public Health Nutrition.

75 FR 39251 - Control of Air Pollution From New Motor Vehicles: Announcement of Public Workshop for Heavy-Duty...

Science.gov (United States)

2010-07-08

... ENVIRONMENTAL PROTECTION AGENCY [FRL-9173-5] Control of Air Pollution From New Motor Vehicles: Announcement of Public Workshop for Heavy-Duty Diesel Engines Employing Selective Catalyst Reduction Technology... engine manufacturers have recently begun utilizing a NO X emission control technology called selective...

Nuclear Innovation Workshops Report

Energy Technology Data Exchange (ETDEWEB)

Jackson, John Howard [Idaho National Lab. (INL), Idaho Falls, ID (United States); Allen, Todd Randall [Idaho National Lab. (INL), Idaho Falls, ID (United States); Hildebrandt, Philip Clay [Idaho National Lab. (INL), Idaho Falls, ID (United States); Baker, Suzanne Hobbs [Idaho National Lab. (INL), Idaho Falls, ID (United States)

2015-09-01

The Nuclear Innovation Workshops were held at six locations across the United States on March 3-5, 2015. The data collected during these workshops has been analyzed and sorted to bring out consistent themes toward enhancing innovation in nuclear energy. These themes include development of a test bed and demonstration platform, improved regulatory processes, improved communications, and increased public-private partnerships. This report contains a discussion of the workshops and resulting themes. Actionable steps are suggested at the end of the report. This revision has a small amount of the data in Appendix C removed in order to avoid potential confusion.

The use of adjuvant radiotherapy in elderly patients with early-stage breast cancer: changes in practice patterns after publication of Cancer and Leukemia Group B 9343.

Science.gov (United States)

Palta, Manisha; Palta, Priya; Bhavsar, Nrupen A; Horton, Janet K; Blitzblau, Rachel C

2015-01-15

The Cancer and Leukemia Group B (CALGB) 9343 randomized phase 3 trial established lumpectomy and adjuvant therapy with tamoxifen alone, rather than both radiotherapy and tamoxifen, as a reasonable treatment course for women aged >70 years with clinical stage I (AJCC 7th edition), estrogen receptor-positive breast cancer. An analysis of the Surveillance, Epidemiology, and End Results (SEER) registry was undertaken to assess practice patterns before and after the publication of this landmark study. The SEER database from 2000 to 2009 was used to identify 40,583 women aged ≥70 years who were treated with breast-conserving surgery for clinical stage I, estrogen receptor-positive and/or progesterone receptor-positive breast cancer. The percentage of patients receiving radiotherapy and the type of radiotherapy delivered was assessed over time. Administration of radiotherapy was further assessed across age groups; SEER cohort; and tumor size, grade, and laterality. Approximately 68.6% of patients treated between 2000 and 2004 compared with 61.7% of patients who were treated between 2005 and 2009 received some form of adjuvant radiotherapy (P < .001). Coinciding with a decline in the use of external beam radiotherapy, there was an increase in the use of implant radiotherapy from 1.4% between 2000 and 2004 to 6.2% between 2005 to 2009 (P < .001). There were significant reductions in the frequency of radiotherapy delivery over time across age groups, tumor size, and tumor grade and regardless of laterality (P < .001 for all). Randomized phase 3 data support the omission of adjuvant radiotherapy in elderly women with early-stage breast cancer. Analysis of practice patterns before and after the publication of these data indicates a significant decline in radiotherapy use; however, nearly two-thirds of women continue to receive adjuvant radiotherapy. © 2014 American Cancer Society.

Adjuvants are key factors for the development of future vaccines: Lessons from the Finlay Adjuvant platform

Directory of Open Access Journals (Sweden)

Oliver ePérez

2013-12-01

Full Text Available The development of effective vaccines against neglected diseases, especially those associated with poverty and social deprivation, is urgently needed. Modern vaccine technologies and a better understanding of the immune response have provided scientists with the tools for rational and safer design of subunit vaccines. Often, however, subunit vaccines do not elicit strong immune responses, highlighting the need to incorporate better adjuvants; this step therefore becomes a key factor for vaccine development. In this review we outline some key features of modern vaccinology that are linked with the development of better adjuvants. In line with the increased desire to obtain novel adjuvants for future vaccines, the Finlay Adjuvant Platform offers a novel approach for the development of new and effective adjuvants. The Finlay Adjuvants (AFs, AFPL (proteoliposome and AFCo (cochleate, were initially designed for parenteral and mucosal applications, and constitute potent adjuvants for the induction of Th1 responses against several antigens. This review summarizes the status of the Finlay technology in producing promising adjuvants for unsolved-vaccine diseases including mucosal approaches and therapeutic vaccines. Ideas related to adjuvant classification, adjuvant selection, and their possible influence on innate recognition via multiple toll-like receptors are also discussed.

Opening Session - Introductory remarks for Workshop on Accident Tolerant Fuel. OECD/NEA Workshop on Accident Tolerant Fuels, Workshop Expectations

International Nuclear Information System (INIS)

Dujardin, Thierry; Gulliford, Jim; Massara, Simone; Pasamehmetoglu, K.

2013-01-01

The workshop opened with the welcome address from Th. Dujardin (OECD/NEA), NEA Deputy Director. Th. Dujardin recalled the integrated NEA response to the dramatic Fukushima-Daiichi events performed by three standing technical committees: the Committee on Nuclear Regulatory Activities (CNRA), the Committee on the Safety of Nuclear Installations (CSNI) and the Committee on Radiation Protection and Public Health (CRPPH). J. Gulliford (OECD/NEA) placed the workshop in the context of the activities of the Nuclear Science Committee within the framework of the NEA response to Fukushima- Daiichi. K. Pasamehmetoglu (INL, US) explained the main goals of the workshop oriented towards defining requirements for selection among various options during the feasibility phase of the development process, and not towards identifying and proposing design solutions

Adjuvant therapy for gastric cancer: what have we learned since INT0116?

Science.gov (United States)

Jácome, Alexandre A; Sankarankutty, Ajith K; dos Santos, José Sebastião

2015-04-07

Gastric cancer is one of the main cancer-related causes of death worldwide. The curative treatment of gastric cancer consists of tumor resection and lymphadenectomy. However, surgical treatment alone is associated with high recurrence rates. Adjuvant treatment strategies have been studied over the last decades, but there have been controversial results from the initial studies. The pivotal INT0116 study demonstrated that the use of adjuvant chemoradiotherapy with 5-fluorouracil increases relapse-free and overall survival, and it has been adopted across the Western world. The high toxicity of radiochemotherapy and suboptimal surgical treatment employed, with fewer than 10% of the patients submitted to D2 lymphadenectomy, were the main study limitations. Since its publication, other adjuvant treatment modalities have been studied, and radiochemotherapy is being refined to improve its efficacy and safety. A multimodal approach has been demonstrated to significantly increase relapse-free and overall survival, and it can be offered in the form of perioperative chemotherapy, adjuvant chemoradiotherapy or adjuvant chemotherapy, regardless of the extent of lymphadenectomy. The objective of the present review is to report the major advances obtained in the last decades in the adjuvant treatment of gastric cancer as well as the perspectives of treatment based on recent knowledge of the molecular biology of the disease.

Understanding Australian policies on public health using social and political science theories: reflections from an Academy of the Social Sciences in Australia Workshop.

Science.gov (United States)

Baum, Fran; Graycar, Adam; Delany-Crowe, Toni; de Leeuw, Evelyne; Bacchi, Carol; Popay, Jennie; Orchard, Lionel; Colebatch, Hal; Friel, Sharon; MacDougall, Colin; Harris, Elizabeth; Lawless, Angela; McDermott, Dennis; Fisher, Matthew; Harris, Patrick; Phillips, Clare; Fitzgerald, Jane

2018-04-19

There is strong, and growing, evidence documenting health inequities across the world. However, most governments do not prioritize policies to encourage action on the social determinants of health and health equity. Furthermore, despite evidence concerning the benefits of joined-up, intersectoral policy to promote health and health equity, it is rare for such policy approaches to be applied systematically. To examine the usefulness of political and social science theory in understanding the reasons for this disjuncture between evidence and practice, researchers and public servants gathered in Adelaide for an Academy of the Social Sciences in Australia (ASSA) Workshop. This paper draws together the learnings that emerged from the Workshop, including key messages about the usefulness of various theories as well as insights drawn from policy practice. Discussions during the Workshop highlighted that applying multiple theories is particularly helpful in directing attention to, and understanding, the influence of all stages of the policy process; from the construction and framing of policy problems, to the implementation of policy and evaluation of outcomes, including those outcomes that may be unintended. In addition, the Workshop emphasized the value of collaborations among public health researchers, political and social scientists and public servants to open up critical discussion about the intersections between theory, research evidence and practice. Such critique is vital to render visible the processes through which particular sources of knowledge may be privileged over others and to examine how political and bureaucratic environments shape policy proposals and implementation action.

Special workshop on lung dosimetry

International Nuclear Information System (INIS)

Fisher, D.R.

1983-01-01

A Special Workshop on Lung Dosimetry was convened in Salt Lake City, Utah, on April 21-22, 1982, to stimulate the use of improved radiation dosimetry and to formulate a stronger basis for dose-response relationships for inhaled radionuclides. The two-day workshop was held in conjunction with the 30th Annual Meeting of the Radiation Research Society. Publication is planned

77 FR 59404 - Food Defense; Public Workshop

Science.gov (United States)

2012-09-27

... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2012-N-0001... Regional Office (SWRO), in co-sponsorship with Oklahoma State University (OSU), Robert M. Kerr Food... workshop will be held at the Robert M. Kerr Food & Agricultural Products Center, Oklahoma State University...

WWER-1000 reactor simulator. Workshop material

International Nuclear Information System (INIS)

2003-01-01

The International Atomic Energy Agency (IAEA) has established an activity in nuclear reactor simulation computer programs to assist its Member States in education. The objective is to provide, for a variety of advanced reactor types, insight and practice in their operational characteristics and their response to perturbations and accident situations. To achieve this, the IAEA arranges for the development and distribution of simulation programs and educational material and sponsors courses and workshops. The workshops are in two parts: techniques and tools for reactor simulator development; and the use of reactor simulators in education. Workshop material for the first part is covered in the IAEA publication: Training Course Series 12, 'Reactor Simulator Development' (2001). Course material for workshops using a pressurized water reactor (PWR) Simulator developed for the IAEA by Cassiopeia Technologies Inc. of Canada is presented in the IAEA publication: Training Course Series No. 22 'Pressurized Water Reactor Simulator' (2003) and Training Course Series No. 23 'Boiling Water Reactor Simulator' (2003). This report consists of course material for workshops using the WWER-1000 Reactor Department Simulator from the Moscow Engineering and Physics Institute, Russian Federation. N. V. Tikhonov and S. B. Vygovsky of the Moscow Engineering and Physics Institute prepared this report for the IAEA

Proceedings of the second data acquisition system workshop

International Nuclear Information System (INIS)

Ohska, T.K.

1988-02-01

The second data acquisition system workshop was held on July 18 and 19, 1986 at the National Laboratory for High Energy Physics (KEK). The organizers had one thing in mind when this workshop was planned. It was wanted to make a record of mistakes in designing and building the electronic system. The time when this workshop was held was just before the completion of the TRISTAN detectors when everyone was very busy. Brilliant achievements have been published every year in the world, but the hard earned experience on what should not be done does not appear on publication. To record it while it is still hot was the basic motivation of this workshop. More than 100 people attended the workshop, and some speakers did excellently what the organizers hoped to do, but some talked on their great achievements only. The organizers are very thankful to everybody who helped before, during and after the workshop. If possible, it should be asked all speakers to hand in their write-ups on the day of the workshop. Actually, the last write-up was received almost one year late, and the publication of this report delayed. In this book, those write-ups are collected. (Kako, I.)

32 CFR 705.30 - Aerospace Education Workshop.

Science.gov (United States)

2010-07-01

... 32 National Defense 5 2010-07-01 2010-07-01 false Aerospace Education Workshop. 705.30 Section 705... REGULATIONS AND OFFICIAL RECORDS PUBLIC AFFAIRS REGULATIONS § 705.30 Aerospace Education Workshop. (a) This... of Naval Operations has cognizance of all assistance provided by the Navy to all Aerospace Education...

Skin Microbiota Workshop: Multidisciplinary Perspectives, Challenges and Opportunities

Science.gov (United States)

2014-12-08

SECURITY CLASSIFICATION OF: This report details the outcome of the 1st Skin Microbiota Workshop, Boulder, CO, held on October 15th-16th 2012. The...Sep-2014 Approved for Public Release; Distribution Unlimited Final Report: Skin Microbiota Workshop: Multidisciplinary Perspectives, Challenges and...Number of Papers published in peer-reviewed journals: Number of Papers published in non peer-reviewed journals: Final Report: Skin Microbiota Workshop

Summary report on the C.N.R.A. workshop ''investing in trust - nuclear regulators and the public''

International Nuclear Information System (INIS)

Laaksonen, J.

2001-01-01

The general public is concerned with the risks involved in the use of nuclear power, and has a legitimate desire for reliable and impartial information. It is important to convince the people that the regulatory body works for them and for their safety and is not promoting the use of nuclear energy or any other interests. A necessary condition for being trustworthy is to be well known, efficient channels are needed, a good information must be transferred to two directions, information must be easily available to the public are some important points developed in this workshop. (N.C.)

Vaxjo: A Web-Based Vaccine Adjuvant Database and Its Application for Analysis of Vaccine Adjuvants and Their Uses in Vaccine Development

Directory of Open Access Journals (Sweden)

Samantha Sayers

2012-01-01

Full Text Available Vaccine adjuvants are compounds that enhance host immune responses to co-administered antigens in vaccines. Vaxjo is a web-based central database and analysis system that curates, stores, and analyzes vaccine adjuvants and their usages in vaccine development. Basic information of a vaccine adjuvant stored in Vaxjo includes adjuvant name, components, structure, appearance, storage, preparation, function, safety, and vaccines that use this adjuvant. Reliable references are curated and cited. Bioinformatics scripts are developed and used to link vaccine adjuvants to different adjuvanted vaccines stored in the general VIOLIN vaccine database. Presently, 103 vaccine adjuvants have been curated in Vaxjo. Among these adjuvants, 98 have been used in 384 vaccines stored in VIOLIN against over 81 pathogens, cancers, or allergies. All these vaccine adjuvants are categorized and analyzed based on adjuvant types, pathogens used, and vaccine types. As a use case study of vaccine adjuvants in infectious disease vaccines, the adjuvants used in Brucella vaccines are specifically analyzed. A user-friendly web query and visualization interface is developed for interactive vaccine adjuvant search. To support data exchange, the information of vaccine adjuvants is stored in the Vaccine Ontology (VO in the Web Ontology Language (OWL format.

Vaxjo: a web-based vaccine adjuvant database and its application for analysis of vaccine adjuvants and their uses in vaccine development.

Science.gov (United States)

Sayers, Samantha; Ulysse, Guerlain; Xiang, Zuoshuang; He, Yongqun

2012-01-01

Vaccine adjuvants are compounds that enhance host immune responses to co-administered antigens in vaccines. Vaxjo is a web-based central database and analysis system that curates, stores, and analyzes vaccine adjuvants and their usages in vaccine development. Basic information of a vaccine adjuvant stored in Vaxjo includes adjuvant name, components, structure, appearance, storage, preparation, function, safety, and vaccines that use this adjuvant. Reliable references are curated and cited. Bioinformatics scripts are developed and used to link vaccine adjuvants to different adjuvanted vaccines stored in the general VIOLIN vaccine database. Presently, 103 vaccine adjuvants have been curated in Vaxjo. Among these adjuvants, 98 have been used in 384 vaccines stored in VIOLIN against over 81 pathogens, cancers, or allergies. All these vaccine adjuvants are categorized and analyzed based on adjuvant types, pathogens used, and vaccine types. As a use case study of vaccine adjuvants in infectious disease vaccines, the adjuvants used in Brucella vaccines are specifically analyzed. A user-friendly web query and visualization interface is developed for interactive vaccine adjuvant search. To support data exchange, the information of vaccine adjuvants is stored in the Vaccine Ontology (VO) in the Web Ontology Language (OWL) format.

1998 federal technical standards workshop: Proceedings

Energy Technology Data Exchange (ETDEWEB)

NONE

1998-10-01

The theme for the 1998 workshop was Standards Management -- A World of Change and Opportunities. The workshop`s goal was to further the implementation of the National Technology Transfer and Advancement Act of 1995 (Public Law 104-113) through the sharing of standards management success stories, lessons learned, and emerging initiatives within the Executive Branch of the Federal Government. The target audience for this workshop included agency/department and contractor personnel and representatives of standards developing organizations that either used technical standards in their work for the Federal Government of participated in standards writing/management activities in support of the missions and programs of Federal agencies/departments. As with previous standards workshops sponsored by the DOE, views on the technical subject areas under the workshop theme were solicited from and provided by agency Standards Executives and standards program managers, voluntary standards organizations, and the private sector. This report includes vugraphs of the presentations.

Continuing Education Workshops in Bioinformatics Positively Impact Research and Careers.

Science.gov (United States)

Brazas, Michelle D; Ouellette, B F Francis

2016-06-01

Bioinformatics.ca has been hosting continuing education programs in introductory and advanced bioinformatics topics in Canada since 1999 and has trained more than 2,000 participants to date. These workshops have been adapted over the years to keep pace with advances in both science and technology as well as the changing landscape in available learning modalities and the bioinformatics training needs of our audience. Post-workshop surveys have been a mandatory component of each workshop and are used to ensure appropriate adjustments are made to workshops to maximize learning. However, neither bioinformatics.ca nor others offering similar training programs have explored the long-term impact of bioinformatics continuing education training. Bioinformatics.ca recently initiated a look back on the impact its workshops have had on the career trajectories, research outcomes, publications, and collaborations of its participants. Using an anonymous online survey, bioinformatics.ca analyzed responses from those surveyed and discovered its workshops have had a positive impact on collaborations, research, publications, and career progression.

Evaluating patient and public involvement in health research: from theoretical model to practical workshop.

Science.gov (United States)

Gibson, Andy; Welsman, Jo; Britten, Nicky

2017-10-01

There is a growing literature on evaluating aspects of patient and public involvement (PPI). We have suggested that at the core of successful PPI is the dynamic interaction of different forms of knowledge, notably lay and professional. We have developed a four-dimensional theoretical framework for understanding these interactions. We explore the practical utility of the theoretical framework as a tool for mapping and evaluating the experience of PPI in health services research. We conducted three workshops with different PPI groups in which participants were invited to map their PPI experiences on wall charts representing the four dimensions of our framework. The language used to describe the four dimensions was modified to make it more accessible to lay audiences. Participants were given sticky notes to indicate their own positions on the different dimensions and to write explanatory comments if they wished. Participants' responses were then discussed and analysed as a group. The three groups were distinctive in their mapped responses suggesting different experiences in relation to having a strong or weak voice in their organization, having few or many ways of getting involved, addressing organizational or public concerns and believing that the organization was willing to change or not. The framework has practical utility for mapping and evaluating PPI interactions and is sensitive to differences in PPI experiences within and between different organizations. The workshops enabled participants to reflect collaboratively on their experiences with a view to improving PPI experiences and planning for the future. © 2017 The Authors Health Expectations published by John Wiley & Sons Ltd.

How to put on an ANS teachers' workshop

International Nuclear Information System (INIS)

Besmann, T.M.

1991-01-01

One of the most successful public outreach programs organized by the American Nuclear Society (ANS) has been the teachers' workshops. They are so highly thought of that a national meeting is considered incomplete without an attendant workshop. The workshops are also included in topical meetings, and a number are simply organized by local sections with no connection to a technical meeting. The accumulated experience with these workshops has now matured to where a set of reasonable guidelines can be established, although there are no guarantees of success or hard and fast rules

ENS PIME 2000: 12th international workshop on nuclear public information in practice. Transactions: Case studies, discussion documents, posters, videos

Energy Technology Data Exchange (ETDEWEB)

NONE

2000-07-01

Papers presented at this Meeting were devoted to the following main subjects: European key issues concerning nuclear power; Workshop dealing with building and maintaining media relations; Climatic change; waste management; siting new NPPs, INES scale revisited; contacts of regulators with the public; Ethics and nuclear energy.

ENS PIME 2000: 12th international workshop on nuclear public information in practice. Transactions: Case studies, discussion documents, posters, videos

International Nuclear Information System (INIS)

2000-01-01

Papers presented at this Meeting were devoted to the following main subjects: European key issues concerning nuclear power; Workshop dealing with building and maintaining media relations; Climatic change; waste management; siting new NPPs, INES scale revisited; contacts of regulators with the public; Ethics and nuclear energy

Proceedings of the Radon national action plan workshop

International Nuclear Information System (INIS)

Chevet, Pierre-Franck; Godet, Jean-Luc; Tirmarche, Margot; Strand, Per; Mrdakovic Popic, Jelena; Dysvik, Solveig; Skjold, Anne Marit; Vallet, Benoit; Van Deventer, Emilie; Colgan, Tony; ); Mundigl, Stefan; ); Magnusson, S.; Long, Bill; McBurney, Ruth; Thompson, P.A; Pollard, David; Fenton, David; Long, Stephanie; Dehandschutter, Boris; Murith, Christophe; Skeppstroem, Kirlna; Petrova, Karla; Davidkova, Jana; Pravdova, Eva; Kiselev, Sergey; Mc Coll, Neil; Vallet, Jeremie; Rannou, Alain; Kurttio, Paivi; Martinsen, Finn; Roulet, Claude-Alain; Goyette, Joelle; Frutos, Borja; Olaya, Manuel; Linares Alemparte, Pilar; Marinko, Janez; Garcia-Talavera, Marta; Pedrazzi, Lisa; Mc Laughlin, James; Gutierrez-Villanueva, Jose-Luis; Janssens, Augustin

2015-01-01

Following the publication of the new European Basic Safety Standards Directive (the Council Directive 2013/59/EURATOM ), published in January 2014, Member States of the European Union have 4 years to incorporate it and to prepare or update their strategy for reducing radon concentration and the associated national radon action plan. Under a joint initiative from ASN and NRPA, 20 European countries, represented by authorities in charge of Radiation Protection, Health, Labour and Housing and Landscaping were brought together during a workshop on national radon action plans. The objective of the workshop, held in ASN's premises, was to share the views and experiences concerning national strategies for reducing radon exposure of the population and associated lung cancer risk. The radon workshop was supported by the World Health Organisation (WHO), the International Atomic Energy Agency (IAEA), the Heads of European Radiation protection Control Authorities (HERCA) and the European Commission (EC). Authorities from USA (EPA, CRCPD), Canada (CNSC) and Russia (FMBA) and the European Radon Association (ERA) also participated in the workshop. This radon workshop has offered the opportunity to compare the actions in place or in preparation in different countries aiming at reducing radon exposure in home and dwellings, in buildings with public access (i.e. schools) and in workplaces. Preventive and corrective solutions, associated with incentives and communication to increase the public awareness, as well as education and training actions for different actors concerned, have been presented and discussed. The question about the relative place of regulation in the national strategy has been considered as an important key point. This document brings together the presentations (slides) given at the workshop. The main conclusions of the workshop are presented at the end of the document

Workshop on Women of Applied Mathematics: Research and Leadership

Energy Technology Data Exchange (ETDEWEB)

Dianne P. O' Leary; Tamara G. Kolda

2004-09-28

We held a two and a half day workshop on Women of Applied Mathematics: Research and Leadership at the University of Maryland in College Park, Maryland, October 8--10, 2003. The workshop provided a technical and professional forum for eleven senior women and twenty-four early-career women in applied mathematics. Each participant committed to an outreach activity and publication of a report on the workshop's web site. The final session of the workshop produced recommendations for future action.

Laser vaccine adjuvants

Science.gov (United States)

Kashiwagi, Satoshi; Brauns, Timothy; Gelfand, Jeffrey; Poznansky, Mark C

2014-01-01

Immunologic adjuvants are essential for current vaccines to maximize their efficacy. Unfortunately, few have been found to be sufficiently effective and safe for regulatory authorities to permit their use in vaccines for humans and none have been approved for use with intradermal vaccines. The development of new adjuvants with the potential to be both efficacious and safe constitutes a significant need in modern vaccine practice. The use of non-damaging laser light represents a markedly different approach to enhancing immune responses to a vaccine antigen, particularly with intradermal vaccination. This approach, which was initially explored in Russia and further developed in the US, appears to significantly improve responses to both prophylactic and therapeutic vaccines administered to the laser-exposed tissue, particularly the skin. Although different types of lasers have been used for this purpose and the precise molecular mechanism(s) of action remain unknown, several approaches appear to modulate dendritic cell trafficking and/or activation at the irradiation site via the release of specific signaling molecules from epithelial cells. The most recent study, performed by the authors of this review, utilized a continuous wave near-infrared laser that may open the path for the development of a safe, effective, low-cost, simple-to-use laser vaccine adjuvant that could be used in lieu of conventional adjuvants, particularly with intradermal vaccines. In this review, we summarize the initial Russian studies that have given rise to this approach and comment upon recent advances in the use of non-tissue damaging lasers as novel physical adjuvants for vaccines. PMID:25424797

Achievements and challenges in nuclear regulatory communication with the public. Outcome from the CNRA Workshops held in 2000, 2004 and 2007

International Nuclear Information System (INIS)

Joerle, Anders; Besenyei, Elisabeth; Calvo, Marina; Hah, Yeon-Hee; Hayden, Elizabeth; Herwig, Laurel; Kaliberda, Elena; Ostreng, Anne Marit; Robinson, Felicity; Storey, Peter; Yano, Mari; Zemanova, Dagmar; Chanial, Luc; Degueldre, Didier; Isaksson, Risto; Van Nuffelen, Dominique; Treier, Anton; Yoshimura, Uichiro; Gauvain, Jean

2008-06-01

After having identified that the public trust towards the regulators could be very different from one country to another even though they are neighbours, the NEA Committee on Nuclear Regulatory Activities (CNRA) has developed an activity in public communication and three successful international workshops have been held during this last decade: 1. Paris, December 2000 - Investing in Trust: Nuclear Regulators and the Public; 2. Ottawa, May 2004 - Building, Measuring and Improving Public Confidence; 3. Tokyo, May 2007 - Transparency of Nuclear Regulatory Activities. Collectively these workshops have illustrated valuable feedback experience can be exchanged amongst countries. The objective of this report is to: - summarise the lessons learned from the three CNRA workshops on public communication and related CNRA/WGPC activities over the past decade, - assess their influence on the developments of the different countries' approaches in public communication, - propose a way forward for future work. Over the last two decades public perception of nuclear in some countries has changed substantially and there is an increasing public thirst for information. This, coupled with the generalisation of Freedom of Information Acts in OECD countries and new transparency laws, has resulted in Nuclear Regulatory Organisations (NROs) turning their attention to activities which inform and engage the public. Acts related to the freedom of information (FOI), which give the public the right of access to all types of recorded information, are in force in all OECD countries since 2006 and in some countries they have been supplemented by specific Acts highlighting the importance of Nuclear Regulatory transparency and providing for its implementation. Public expectations regarding the Nuclear Regulatory Organisations (NRO) have significantly increased in every country during the last 20 years and in turn the communication of most NROs has tremendously developed its activities toward informing

76 FR 62373 - Notice of Public Meeting-Cloud Computing Forum & Workshop IV

Science.gov (United States)

2011-10-07

...--Cloud Computing Forum & Workshop IV AGENCY: National Institute of Standards and Technology (NIST), Commerce. ACTION: Notice. SUMMARY: NIST announces the Cloud Computing Forum & Workshop IV to be held on... to help develop open standards in interoperability, portability and security in cloud computing. This...

75 FR 16157 - Pharmaceutical Supply Chain; Public Workshop

Science.gov (United States)

2010-03-31

... supply of high quality, safe, and effective drug products and drug ingredients depends upon a series of... patients. Through a series of plenary sessions and working group breakout sessions, the workshop will... environment. Share improvements in programs and technology. Identify any barriers to securing the entire...

77 FR 74829 - Notice of Public Meeting-Cloud Computing and Big Data Forum and Workshop

Science.gov (United States)

2012-12-18

...--Cloud Computing and Big Data Forum and Workshop AGENCY: National Institute of Standards and Technology... Standards and Technology (NIST) announces a Cloud Computing and Big Data Forum and Workshop to be held on... followed by a one-day hands-on workshop. The NIST Cloud Computing and Big Data Forum and Workshop will...

The Assessment and Management of Suicide Risk: State of Workshop Education

OpenAIRE

Pisani, Anthony R.; Cross, Wendi F.; Gould, Madelyn S.

2011-01-01

A systematic search of popular and scholarly databases identified workshops that addressed general clinical competence in the assessment or management of suicide risk, targeted mental health professionals, and had at least one peerreviewed publication. We surveyed workshop developers and examined empirical articles associated with each workshop. The state of workshop education is characterized by presenting the learning objectives, educational formats, instructor factors, and evaluation studi...

The Assessment and Management of Suicide Risk: State of Workshop Education

Science.gov (United States)

Pisani, Anthony R.; Cross, Wendi F.; Gould, Madelyn S.

2011-01-01

A systematic search of popular and scholarly databases identified workshops that addressed general clinical competence in the assessment or management of suicide risk, targeted mental health professionals, and had at least one peer-reviewed publication. We surveyed workshop developers and examined empirical articles associated with each workshop.…

The Astronomy Workshop

Science.gov (United States)

Hamilton, D. P.; Asbury, M. L.; Proctor, A.

2001-12-01

The Astronomy Workshop (http://janus.astro.umd.edu) is an interactive online astronomy resource developed, and maintained at the University of Maryland, for use by students, educators and the general public. The Astronomy Workshop has been extensively tested and used successfully at many different levels, including High School and Junior High School science classes, University introductory astronomy courses, and University intermediate and advanced astronomy courses. Some topics currently covered in the Astronomy Workshop are: Animated Orbits of Planets and Moons: The orbits of the nine planets and 91 known planetary satellites are shown in animated, to-scale drawings. The orbiting bodies move at their correct relative speeds about their parent, which is rendered as an attractive, to-scale gif image. Solar System Collisions: This most popular of our applications shows what happens when an asteroid or comet with user-defined size and speed impacts a given planet. The program calculates many effects, including the country impacted (if Earth is the target), energy of the explosion, crater size, magnitude of the planetquake generated. It also displays a relevant image (e.g. terrestrial crater, lunar crater, etc.). Planetary and Satellite Data Calculators: These tools allow the user to easily calculate physical data for all of the planets or satellites simultaneously, making comparison very easy. Orbital Simulations: These tools allow the student to investigate different aspects of the three-body problem of celestial mechanics. Astronomy Workshop Bulletin Board: Get innovative teaching ideas and read about in-class experiences with the Astronomy Workshop. Share your ideas with other educators by posting on the Bulletin Board. Funding for the Astronomy Workshop is provided by the National Science Foundation.

Vaccines, adjuvants and autoimmunity.

Science.gov (United States)

Guimarães, Luísa Eça; Baker, Britain; Perricone, Carlo; Shoenfeld, Yehuda

2015-10-01

Vaccines and autoimmunity are linked fields. Vaccine efficacy is based on whether host immune response against an antigen can elicit a memory T-cell response over time. Although the described side effects thus far have been mostly transient and acute, vaccines are able to elicit the immune system towards an autoimmune reaction. The diagnosis of a definite autoimmune disease and the occurrence of fatal outcome post-vaccination have been less frequently reported. Since vaccines are given to previously healthy hosts, who may have never developed the disease had they not been immunized, adverse events should be carefully accessed and evaluated even if they represent a limited number of occurrences. In this review of the literature, there is evidence of vaccine-induced autoimmunity and adjuvant-induced autoimmunity in both experimental models as well as human patients. Adjuvants and infectious agents may exert their immune-enhancing effects through various functional activities, encompassed by the adjuvant effect. These mechanisms are shared by different conditions triggered by adjuvants leading to the autoimmune/inflammatory syndrome induced by adjuvants (ASIA syndrome). In conclusion, there are several case reports of autoimmune diseases following vaccines, however, due to the limited number of cases, the different classifications of symptoms and the long latency period of the diseases, every attempt for an epidemiological study has so far failed to deliver a connection. Despite this, efforts to unveil the connection between the triggering of the immune system by adjuvants and the development of autoimmune conditions should be undertaken. Vaccinomics is a field that may bring to light novel customized, personalized treatment approaches in the future. Copyright © 2015 Elsevier Ltd. All rights reserved.

Report on the Marine Imaging Workshop 2017

Directory of Open Access Journals (Sweden)

Timm Schoening

2017-06-01

Full Text Available Marine optical imaging has become a major assessment tool in science, policy and public understanding of our seas and oceans. Methodology in this field is developing rapidly, including hardware, software and the ways of their application. The aim of the Marine Imaging Workshop (MIW is to bring together academics, research scientists and engineers, as well as industrial partners to discuss these developments, along with applications, challenges and future directions. The first MIW was held in Southampton, UK in April 2014. The second MIW, held in Kiel, Germany, in 2017 involved more than 100 attendees, who shared the latest developments in marine imaging through a combination of traditional oral and poster presentations, interactive sessions and focused discussion sessions. This article summarises the topics addressed during the workshop, particularly the outcomes of these discussion sessions for future reference and to make the workshop results available to the open public.

Adjuvants and Their Mechanisms of Action

Directory of Open Access Journals (Sweden)

Masoumeh Foumani

2012-09-01

Full Text Available Adjuvants are chemicals, microbial components, or mammalian proteins that enhance the immune response to vaccine antigens. Reducing vaccine-related adverse effects and inducing specific types of immunity has led to the development of numerous new adjuvants. Adjuvants in experimental and commercial vaccines include aluminum salts (alum, oil emulsions, saponins, immune-stimulating complexes (ISCOMs, liposomes, microparticles, nonionic block copolymers, derivatized polysaccharides, cytokines, and a wide variety of bacterial derivatives. The mechanisms of action of these diverse compounds are different. Factors influencing the selection of an adjuvant include animal species, specific pathogen, vaccine antigen, route of immunization, and type of immunity needed. In this paper we review the current adjuvant types, structure and mechanism of action and their application in the design and production of animal and human vaccines to provide a source for students and researchers in related fields .

Public Benefits and Power Sector Reform. Report from an International Workshop

Energy Technology Data Exchange (ETDEWEB)

Nilsson, Lars J.; Arvidson, Anders; Eberhard, Anton (eds.)

2003-10-01

The Workshop on Public Benefits and Power Sector Reform was motivated by the need to address broader development goals and advance the provision of public benefits in power sector reforms. The primary objectives were: To provide a forum for a discussion among specialists, of how the provision of public benefits can be expanded as power sectors in developing countries are reformed, and review the experience (Day 1). To identify the needs for training and capacity building and institutional arrangements, as well as make recommendations for their design and implementation, for policy makers, regulators, and other professionals in developing countries (Day 2). Public benefits is a socially constructed concept that includes activities that are not adequately conceived by competitive markets. Public benefit policies and programmes include those that expand electricity access to rural areas and the urban poor, improve security of supply, promote energy efficiency and renewable energy, etc. Reforms have indeed been a threat to public benefits as traditionally delivered through electric utilities. However, in many cases public benefit programmes have also been rescued. In fewer cases, public benefit programmes have been conceived in the reform process. From experience so far it is clear that power sector reforms must be made more compatible with broader sustainable development goals. Recognising the need for broader policy integration and putting public benefits higher on the reform agenda points to the importance of reaching beyond energy ministries and power sector experts at an early stage in the reform process. Other actors, such as NGOs and academia, may also be instrumental in monitoring and assessing the impacts of reform. Public benefits can be an integral part of a reform package, or a complement to reform. It does appear that reform creates space and opportunity to achieve public benefits, but someone has to utilise that opportunity. The need to make trade

Public Benefits and Power Sector Reform. Report from an International Workshop

International Nuclear Information System (INIS)

Nilsson, Lars J.; Arvidson, Anders; Eberhard, Anton

2003-10-01

The Workshop on Public Benefits and Power Sector Reform was motivated by the need to address broader development goals and advance the provision of public benefits in power sector reforms. The primary objectives were: To provide a forum for a discussion among specialists, of how the provision of public benefits can be expanded as power sectors in developing countries are reformed, and review the experience (Day 1). To identify the needs for training and capacity building and institutional arrangements, as well as make recommendations for their design and implementation, for policy makers, regulators, and other professionals in developing countries (Day 2). Public benefits is a socially constructed concept that includes activities that are not adequately conceived by competitive markets. Public benefit policies and programmes include those that expand electricity access to rural areas and the urban poor, improve security of supply, promote energy efficiency and renewable energy, etc. Reforms have indeed been a threat to public benefits as traditionally delivered through electric utilities. However, in many cases public benefit programmes have also been rescued. In fewer cases, public benefit programmes have been conceived in the reform process. From experience so far it is clear that power sector reforms must be made more compatible with broader sustainable development goals. Recognising the need for broader policy integration and putting public benefits higher on the reform agenda points to the importance of reaching beyond energy ministries and power sector experts at an early stage in the reform process. Other actors, such as NGOs and academia, may also be instrumental in monitoring and assessing the impacts of reform. Public benefits can be an integral part of a reform package, or a complement to reform. It does appear that reform creates space and opportunity to achieve public benefits, but someone has to utilise that opportunity. The need to make trade

ERM immersion vaccination and adjuvants

DEFF Research Database (Denmark)

Skov, J.; Chettri, J. K.; Jaafar, R. M.

2015-01-01

Two candidate adjuvants were tested with a commercial ERM dip vaccine (AquaVac™ Relera, MSD Animal Health) for rainbow trout in an experimental design compatible with common vaccination practices at farm level, i.e. immersion of fish in vaccine (±adjuvant) for 30 s. The adjuvants were...... the commercial product Montanide™ IMS 1312 VG PR (SEPPIC), and a soluble and ≥98% pure β-glucan from yeast (Saccharomyces cerevisiae) (Sigma-Aldrich). Hence, five experimental groups in duplicate were established and exposed to vaccine and adjuvants in the following combinations: AquaVac™ Relera (alone); Aqua......Vac™ Relera + Montanide™; AquaVac™ Relera + β-glucan; Montanide™ (alone); and β-glucan (alone). Approximately 450 degree days post-vaccination, the fish were bath-challenged with live Yersinia ruckeri to produce survival curves. Blood, skin and gills were sampled at selected time points during the course...

Endogenous and Exogenous Natural Adjuvants for Vaccine Development.

Science.gov (United States)

Bolhassani, Azam; Talebi, Somayeh; Anvar, Ali

2017-01-01

Objective & Background: Various adjuvants are usually co-injected with an antigen for stimulation of effective immune responses. Adjuvants are able to elicit innate immune responses at the injection site. Depending on the activated type of innate responses, adjuvants can modify the quality and quantity of adaptive immune responses. Their mechanisms of action in vaccine development include: a) enhancement of the total antibody titers; b) reduction of the antigen dose; c) induction of potent cell-mediated immunity; d) increase in the speed and duration of the protective response; e) stimulation of mucosal immunity; and f) cross-protection. Up to now, different exogenous adjuvants have been identified to boost immune responses including inorganic compounds, mineral oil, bacterial products, non-bacterial organics, detergents or Quil A, plant saponins, Freund's complete or incomplete adjuvants, and delivery systems. However, some immune responses can be generated in the absence of the exogenous adjuvants. Indeed, endogenous adjuvants released from the cells were known as the danger signals and immunogenic compounds. Several main endogenous adjuvants contain cytokines, chemokines, alarmins, dendritic cells (DCs), toll like receptor (TLR) ligands or agonists, and antibodies. In this review, the immune activities of the natural adjuvants especially endogenous adjuvants and their mechanisms of action are discussed. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Proteoliposome derived cochleate as novel adjuvant.

Science.gov (United States)

Bracho, Gustavo; Lastre, Miriam; del Campo, Judith; Zayas, Caridad; González, Domingo; Gil, Danay; Acevedo, Reinaldo; Taboada, Carlos; Solís, Rosa L; Pérez, Oliver

2006-04-12

Cochleate structures (CS) consist in a highly stable lipid structures that have been reported to be a good antigen delivery system. The incorporation of pathogen associated molecular pattern (PAMP) from bacterial membranes into CS became in a promising approach to develop adjuvants, particularly mucosal adjuvants. Therefore, we prepare CS from proteoliposome (PL) obtained from Neisseria meningitidis B (PLCS) and evaluated it for its capability to stimulate the immune system as well as the adjuvant activity. The ability of PLCS to induce Thl polarization was also explored. The results and the easy capability for new antigen incorporation on CS support its use as adjuvant for immunization with a large variety of pathogen derived antigens and different routes of immunization.

Pressurized water reactor simulator. Workshop material

International Nuclear Information System (INIS)

2003-01-01

The International Atomic Energy Agency (IAEA) has established an activity in nuclear reactor simulation computer programs to assist its Member States in education. The objective is to provide, for a variety of advanced reactor types, insight and practice in their operational characteristics and their response to perturbations and accident situations. To achieve this, the IAEA arranges for the development and distribution of simulation programs and educational material and sponsors courses and workshops. The workshops are in two parts: techniques and tools for reactor simulator development; and the use of reactor simulators in education. Workshop material for the first part is covered in the IAEA Training Course Series No. 12, 'Reactor Simulator Development' (2001). Course material for workshops using a WWER- 1000 reactor department simulator from the Moscow Engineering and Physics Institute, the Russian Federation is presented in the IAEA Training Course Series No. 21 'WWER-1000 Reactor Simulator' (2002). Course material for workshops using a boiling water reactor simulator developed for the IAEA by Cassiopeia Technologies Incorporated of Canada (CTI) is presented in the IAEA publication: Training Course Series No.23 'Boiling Water Reactor Simulator' (2003). This report consists of course material for workshops using a pressurized water reactor simulator

Applications of nanomaterials as vaccine adjuvants

Science.gov (United States)

Zhu, Motao; Wang, Rongfu; Nie, Guangjun

2014-01-01

Vaccine adjuvants are applied to amplify the recipient's specific immune responses against pathogen infection or malignancy. A new generation of adjuvants is being developed to meet the demands for more potent antigen-specific responses, specific types of immune responses, and a high margin of safety. Nanotechnology provides a multifunctional stage for the integration of desired adjuvant activities performed by the building blocks of tailor-designed nanoparticles. Using nanomaterials for antigen delivery can provide high bioavailability, sustained and controlled release profiles, and targeting and imaging properties resulting from manipulation of the nanomaterials’ physicochemical properties. Moreover, the inherent immune-regulating activity of particular nanomaterials can further promote and shape the cellular and humoral immune responses toward desired types. The combination of both the delivery function and immunomodulatory effect of nanomaterials as adjuvants is thought to largely benefit the immune outcomes of vaccination. In this review, we will address the current achievements of nanotechnology in the development of novel adjuvants. The potential mechanisms by which nanomaterials impact the immune responses to a vaccine and how physicochemical properties, including size, surface charge and surface modification, impact their resulting immunological outcomes will be discussed. This review aims to provide concentrated information to promote new insights for the development of novel vaccine adjuvants. PMID:25483497

76 FR 62419 - Science of Abuse Liability Assessment; Public Workshop

Science.gov (United States)

2011-10-07

... Federal Register.) If you need special accommodations due to a disability, please contact Ellen B. Geller... workshop will center on status, needs, new approaches, and paradigms regarding preclinical studies...

FINPIE/97. Workshop proceedings

Energy Technology Data Exchange (ETDEWEB)

NONE

1997-12-31

This publication contains the proceedings of 1997 Finnish Workshop on Power and Industrial Electronics, held in Espoo, Finland, on 26 August, 1997. The programme consisted of technical sessions on Advanced AC Motor Control, Electric Machines and Drives, Advanced Control and Measurement, Power Electronics Systems, Modelling and Simulation, and Power Converters

75 FR 29991 - Schedules for Atlantic Shark Identification Workshops and Protected Species Safe Handling...

Science.gov (United States)

2010-05-28

... Atlantic Shark Identification Workshops and Protected Species Safe Handling, Release, and Identification... (NOAA), Commerce. ACTION: Notice of public workshops. SUMMARY: Free Atlantic Shark Identification..., August, and September of 2010. Certain fishermen and shark dealers are required to attend a workshop to...

"Land of Volcanoes" workshop: a first step in Earth Sciences for "L'Alzina" Public School primary students (4-5 years old)

Science.gov (United States)

Cortés, Jordi; Geyer, Adelina; Díaz, Mabel

2017-04-01

"Land of Volcanoes" is a scientific outreach workshop devised by Adelina Geyer, researcher of the Institute of Earth Sciences Jaume Almera, ICTJA-CSIC. The workshop proposes an approximation to the world of volcanology through the explanation of different concepts related to these geological phenomena: its origin and its characteristics, magma eruptions and their associated hazards, etc. Over the last years, Geyer has developed the workshop in the context of different outreach activities for an audience formed, not only but mainly, by secondary school students. At the beginning of 2016, as a result of different informal contacts between ICTJA-CSIC Communication Unit and Mabel Díaz, teacher of the "L'Alzina" public school (Molins de Rei), arose the idea of developing Geyer's workshop in front of 26 students aged 4-5 years old, primary students. Díaz explains that it is "in the age ranged between 0 and 6 years when observation and hands-on activities are important elements of the learning process", although she adds that " primary students are usually not seen as potential audiences of this type of outreach activities and workshops". Díaz says that "Science is simple: it is about observing, asking questions and finding answers, the same that children, even the smallest, do constantly." Adelina Geyer accepted the challenge of conducting the "Land of Volcanoes" workshop in front of 4-5 year old children, although it was necessary to adapt its format and content to the new audience. Meanwhile, students prepared the session following the same process used in the project work system employed at the school and that started from two questions: "What do we know about volcanoes? What we want to know about them?" On June 3rd 2016, Adelina Geyer conducted "Land of Volcanoes" workshop at l'Alzina public school in front of a classroom of 4-5 years old students. The activity was divided in two parts with a total duration of 45 minutes: 1) Brief introductory talk: this part

t4 Workshop Report*

Science.gov (United States)

Kleensang, Andre; Maertens, Alexandra; Rosenberg, Michael; Fitzpatrick, Suzanne; Lamb, Justin; Auerbach, Scott; Brennan, Richard; Crofton, Kevin M.; Gordon, Ben; Fornace, Albert J.; Gaido, Kevin; Gerhold, David; Haw, Robin; Henney, Adriano; Ma’ayan, Avi; McBride, Mary; Monti, Stefano; Ochs, Michael F.; Pandey, Akhilesh; Sharan, Roded; Stierum, Rob; Tugendreich, Stuart; Willett, Catherine; Wittwehr, Clemens; Xia, Jianguo; Patton, Geoffrey W.; Arvidson, Kirk; Bouhifd, Mounir; Hogberg, Helena T.; Luechtefeld, Thomas; Smirnova, Lena; Zhao, Liang; Adeleye, Yeyejide; Kanehisa, Minoru; Carmichael, Paul; Andersen, Melvin E.; Hartung, Thomas

2014-01-01

Summary Despite wide-spread consensus on the need to transform toxicology and risk assessment in order to keep pace with technological and computational changes that have revolutionized the life sciences, there remains much work to be done to achieve the vision of toxicology based on a mechanistic foundation. A workshop was organized to explore one key aspect of this transformation – the development of Pathways of Toxicity (PoT) as a key tool for hazard identification based on systems biology. Several issues were discussed in depth in the workshop: The first was the challenge of formally defining the concept of a PoT as distinct from, but complementary to, other toxicological pathway concepts such as mode of action (MoA). The workshop came up with a preliminary definition of PoT as “A molecular definition of cellular processes shown to mediate adverse outcomes of toxicants”. It is further recognized that normal physiological pathways exist that maintain homeostasis and these, sufficiently perturbed, can become PoT. Second, the workshop sought to define the adequate public and commercial resources for PoT information, including data, visualization, analyses, tools, and use-cases, as well as the kinds of efforts that will be necessary to enable the creation of such a resource. Third, the workshop explored ways in which systems biology approaches could inform pathway annotation, and which resources are needed and available that can provide relevant PoT information to the diverse user communities. PMID:24127042

78 FR 73500 - Schedules for Atlantic Shark Identification Workshops and Protected Species Safe Handling...

Science.gov (United States)

2013-12-06

... for Atlantic Shark Identification Workshops and Protected Species Safe Handling, Release, and... Administration (NOAA), Commerce. ACTION: Notice of public workshops. SUMMARY: Free Atlantic Shark Identification..., February, and March of 2014. Certain fishermen and shark dealers are required to attend a workshop to meet...

78 FR 54456 - Schedules for Atlantic Shark Identification Workshops and Protected Species Safe Handling...

Science.gov (United States)

2013-09-04

... for Atlantic Shark Identification Workshops and Protected Species Safe Handling, Release, and... Administration (NOAA), Commerce. ACTION: Notice of public workshops. SUMMARY: Free Atlantic Shark Identification..., November, and December of 2013. Certain fishermen and shark dealers are required to attend a workshop to...

77 FR 32950 - Schedules for Atlantic Shark Identification Workshops and Protected Species Safe Handling...

Science.gov (United States)

2012-06-04

... for Atlantic Shark Identification Workshops and Protected Species Safe Handling, Release, and... Administration (NOAA), Commerce. ACTION: Notice of public workshops. SUMMARY: Free Atlantic Shark Identification..., August, and September of 2012. Certain fishermen and shark dealers are required to attend a workshop to...

75 FR 10217 - Schedules for Atlantic Shark Identification Workshops and Protected Species Safe Handling...

Science.gov (United States)

2010-03-05

... Atlantic Shark Identification Workshops and Protected Species Safe Handling, Release, and Identification... (NOAA), Commerce. ACTION: Notice of public workshops. SUMMARY: NMFS announces free Atlantic Shark... April, May, and June of 2010. Certain fishermen and shark dealers are required to attend a workshop to...

77 FR 12574 - Schedules for Atlantic Shark Identification Workshops and Protected Species Safe Handling...

Science.gov (United States)

2012-03-01

... for Atlantic Shark Identification Workshops and Protected Species Safe Handling, Release, and... Administration (NOAA), Commerce. ACTION: Notice of public workshops. SUMMARY: Free Atlantic Shark Identification..., May, and June of 2012. Certain fishermen and shark dealers are required to attend a workshop to meet...

77 FR 55464 - Schedules for Atlantic Shark Identification Workshops and Protected Species Safe Handling...

Science.gov (United States)

2012-09-10

... for Atlantic Shark Identification Workshops and Protected Species Safe Handling, Release, and... Administration (NOAA), Commerce. ACTION: Notice of public workshops. SUMMARY: Free Atlantic Shark Identification..., November, and December of 2012. Certain fishermen and shark dealers are required to attend a workshop to...

77 FR 73451 - Schedules for Atlantic Shark Identification Workshops and Protected Species Safe Handling...

Science.gov (United States)

2012-12-10

... for Atlantic Shark Identification Workshops and Protected Species Safe Handling, Release, and... Administration (NOAA), Commerce. ACTION: Notice of public workshops. SUMMARY: Free Atlantic Shark Identification..., February, and March of 2013. Certain fishermen and shark dealers are required to attend a workshop to meet...

78 FR 15709 - Schedules for Atlantic Shark Identification Workshops and Protected Species Safe Handling...

Science.gov (United States)

2013-03-12

... for Atlantic Shark Identification Workshops and Protected Species Safe Handling, Release, and... Administration (NOAA), Commerce. ACTION: Notice of public workshops. SUMMARY: Free Atlantic Shark Identification..., May, and June of 2013. Certain fishermen and shark dealers are required to attend a workshop to meet...

75 FR 74693 - Schedules for Atlantic Shark Identification Workshops and Protected Species Safe Handling...

Science.gov (United States)

2010-12-01

... for Atlantic Shark Identification Workshops and Protected Species Safe Handling, Release, and... Administration (NOAA), Commerce. ACTION: Notice of public workshops. SUMMARY: Free Atlantic Shark Identification..., February, and March of 2011. Certain fishermen and shark dealers are required to attend a workshop to meet...

76 FR 34209 - Schedules for Atlantic Shark Identification Workshops and Protected Species Safe Handling...

Science.gov (United States)

2011-06-13

... for Atlantic Shark Identification Workshops and Protected Species Safe Handling, Release, and... Administration (NOAA), Commerce. ACTION: Notice of public workshops. SUMMARY: Free Atlantic Shark Identification..., August, and September of 2011. Certain fishermen and shark dealers are required to attend a workshop to...

76 FR 77214 - Schedules for Atlantic Shark Identification Workshops and Protected Species Safe Handling...

Science.gov (United States)

2011-12-12

... for Atlantic Shark Identification Workshops and Protected Species Safe Handling, Release, and... Administration (NOAA), Commerce. ACTION: Notice of public workshops. SUMMARY: Free Atlantic Shark Identification..., February, and March of 2012. Certain fishermen and shark dealers are required to attend a workshop to meet...

76 FR 11762 - Schedules for Atlantic Shark Identification Workshops and Protected Species Safe Handling...

Science.gov (United States)

2011-03-03

... for Atlantic Shark Identification Workshops and Protected Species Safe Handling, Release, and... Administration (NOAA), Commerce. ACTION: Notice of public workshops. SUMMARY: Free Atlantic Shark Identification..., May, and June of 2011. Certain fishermen and shark dealers are required to attend a workshop to meet...

Adjuvant chemo- and radiotherapy in gastrointestinal tumors

International Nuclear Information System (INIS)

Sendler, A.; Feldmann, H.J.; Fink, U.; Molls, M.; Siewert, J.R.

1995-01-01

In modern surgical oncology, adjuvant therapies are important complementary strategies. In local advanced carcinomas of the gastrointestinal tract, 5-year survival data are still disappointing despite standardized surgery. In this context, it has to be differentiated between adjuvant therapy following complete tumor exstirpation (so-called UICC R 0 resection) and additive therapies following incomplete tumor resections (UICC R 1 or R 2 resection). Modalities in the adjuvant setting are chemotherapy, radiotherapy or the combined radio-/chemotherapy. In esophageal and gastric cancer there is up to now no benefit of postoperative adjuvant therapy. In pancreatic cancer, there are studies indicating a benefit of combined radio-/chemotherapy after complete tumor resection. A standard adjuvant chemotherapeutic treatment is proven in colon cancer stage III (Dukes C) with levamisole and 5-FU. Completely resected rectal carcinoma should be treated postoperatively with combined radio-/chemotherapy. In the common clinical or practical setting, adjuvant therapy is indicated only in locally advanced gastrointestinal tumors following R 0 resection. Postoperative therapy following incomplete tumor resection has its reason only in a palliative intention. (orig.) [de

ENS PIME '99: 11. international workshop on nuclear public information in practice. Transactions. Case studies, discussion documents, posters, videos

Energy Technology Data Exchange (ETDEWEB)

NONE

1999-07-01

The papers of this 11th in the row international meeting were presented during the sessions named as follows: The young generation and communication with the public; Handling minor incidents; Nuclear power - what's it worth? Advertising; It's not what you say, it's how you say it; Workshop: handling the media; inside out communications - communicating with own staff; transport problems; nuclear subsidiaries - the black sheep of the family; campaigns and strategies; general updates and breaking news.

ENS PIME '99: 11. international workshop on nuclear public information in practice. Transactions. Case studies, discussion documents, posters, videos

International Nuclear Information System (INIS)

1999-01-01

The papers of this 11th in the row international meeting were presented during the sessions named as follows: The young generation and communication with the public; Handling minor incidents; Nuclear power - what's it worth? Advertising; It's not what you say, it's how you say it; Workshop: handling the media; inside out communications - communicating with own staff; transport problems; nuclear subsidiaries - the black sheep of the family; campaigns and strategies; general updates and breaking news

West Nile Virus workshop: scientific considerations for tissue donors.

Science.gov (United States)

Brubaker, Scott A; Robert Rigney, P

2012-08-01

This report contains selected excerpts, presented as a summary, from a public workshop sponsored by the American Association of Tissue Banks (AATB) held to discuss West Nile Virus (WNV) and scientific considerations for tissue donors. The daylong workshop was held 9 July 2010 at the Ritz-Carlton Hotel at Tyson's Corner in McLean, Virginia, United States (U.S.). The workshop was designed to determine and discuss scientific information that is known, and what is not known, regarding WNV infection and transmission. The goal is to determine how to fill gaps in knowledge of WNV and tissue donation and transplantation by pursuing relevant scientific studies. This information should ultimately support decisions leading to appropriate tissue donor screening and testing considerations. Discussion topics were related to identifying these gaps and determining possible solutions. Workshop participants included subject-matter experts from the U.S. Food and Drug Administration, the Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, Health Canada, the Public Health Agency of Canada, AATB-accredited tissue banks including reproductive tissue banks, accredited eye banks of the Eye Bank Association of America, testing laboratories, and infectious disease and organ transplantation professionals. After all presentations concluded, a panel addressed this question: "What are the scientific considerations for tissue donors and what research could be performed to address those considerations?" The slide presentations from the workshop are available at: http://www.aatb.org/2010-West-Nile-Virus-Workshop-Presentations.

A Weekend Workshop on Double Stars for Students

Science.gov (United States)

Brewer, Mark; Estrada, Chris; Estrada, Reed; Gillette, Sean

2016-01-01

A weekend double star workshop was held by Vanguard Preparatory for selected eighth grade students with the purpose of introducing them to astrometric observational science. The students were selected based on an essay provided by their language arts class. Collaboration with local visiting astronomers was established to provide telescopes equipped with an astrometric eyepiece, observational supervision, and expertise. During the workshop students learned how to determine the scale constant of an astrometric eyepiece, and the procedure for measuring separations and position angles of double stars. The students compared their data to past measurements reported in the Washington Double Star Catalog. Three goals were set for the student's outcome: 1) observe, record, and report observations of double stars, 2) write a scientific paper for publication in the Journal of Double Star Observations, and 3) present a PowerPoint presentation to their peers. This paper chronicles the planning, preparation, funding, and execution required to complete a double star workshop at a public middle school.

Workshop on Program for Elimination of Requirements Marginal to Safety: Proceedings

International Nuclear Information System (INIS)

Dey, M.

1993-09-01

These are the proceedings of the Public Workshop on the US Nuclear Regulatory Commission's Program for Elimination of Requirements Marginal to Safety. The workshop was held at the Holiday Inn, Bethesda, on April 27 and 28, 1993. The purpose of the workshop was to provide an opportunity for public and industry input to the program. The workshop addressed the institutionalization of the program to review regulations with the purpose of eliminating those that are marginal. The objective is to avoid the dilution of safety efforts. One session was devoted to discussion of the framework for a performance-based regulatory approach. In addition, panelists and attendees discussed scope, schedules and status of specific regulatory items: containment leakage testing requirements, fire protection requirements, requirements for environmental qualification of electrical equipment, requests for information under 10CFR50.54(f), requirements for combustible gas control systems, and quality assurance requirements

Workshop on Program for Elimination of Requirements Marginal to Safety: Proceedings

Energy Technology Data Exchange (ETDEWEB)

Dey, M. [Nuclear Regulatory Commission, Washington, DC (United States). Div. of Safety Issue Resolution; Arsenault, F.; Patterson, M.; Gaal, M. [SCIENTECH, Inc., Rockville, MD (United States)

1993-09-01

These are the proceedings of the Public Workshop on the US Nuclear Regulatory Commission`s Program for Elimination of Requirements Marginal to Safety. The workshop was held at the Holiday Inn, Bethesda, on April 27 and 28, 1993. The purpose of the workshop was to provide an opportunity for public and industry input to the program. The workshop addressed the institutionalization of the program to review regulations with the purpose of eliminating those that are marginal. The objective is to avoid the dilution of safety efforts. One session was devoted to discussion of the framework for a performance-based regulatory approach. In addition, panelists and attendees discussed scope, schedules and status of specific regulatory items: containment leakage testing requirements, fire protection requirements, requirements for environmental qualification of electrical equipment, requests for information under 10CFR50.54(f), requirements for combustible gas control systems, and quality assurance requirements.

Adjuvant chemotherapy for rectal cancer: Is it needed?

Science.gov (United States)

Milinis, Kristijonas; Thornton, Michael; Montazeri, Amir; Rooney, Paul S

2015-01-01

Adjuvant chemotherapy has become a standard treatment of advanced rectal cancer in the West. The benefits of adjuvant chemotherapy after surgery alone have been well established. However, controversy surrounds the use adjuvant chemotherapy in patients who received preoperative chemoradiotherapy, despite it being recommended by a number of international guidelines. Results of recent multicentre randomised control trials showed no benefit of adjuvant chemotherapy in terms of survival and rates of distant metastases. However, concerns exist regarding the quality of the studies including inadequate staging modalities, out-dated chemotherapeutic regimens and surgical approaches and small sample sizes. It has become evident that not all the patients respond to adjuvant chemotherapy and more personalised approach should be employed when considering the benefits of adjuvant chemotherapy. The present review discusses the strengths and weaknesses of the current evidence-base and suggests improvements for future studies. PMID:26677436

78 FR 12042 - Electric Grid Integration Technical Workshops

Science.gov (United States)

2013-02-21

... DEPARTMENT OF ENERGY Electric Grid Integration Technical Workshops AGENCY: Grid Tech Team, U.S. Department of Energy. ACTION: Notice of availability; request for comments. SUMMARY: Notice is hereby given that two documents are publicly available and the Department of Energy is requesting public comments...

MATHEON Workshop 2013

CERN Document Server

Calderbank, Robert; Kutyniok, Gitta; Vybíral, Jan

2015-01-01

Since publication of the initial papers in 2006, compressed sensing has captured the imagination of the international signal processing community, and the mathematical foundations are nowadays quite well understood. Parallel to the progress in mathematics, the potential applications of compressed sensing have been explored by many international groups of, in particular, engineers and applied mathematicians, achieving very promising advances in various areas such as communication theory, imaging sciences, optics, radar technology, sensor networks, or tomography. Since many applications have reached a mature state, the research center MATHEON in Berlin focusing on "Mathematics for Key Technologies", invited leading researchers on applications of compressed sensing from mathematics, computer science, and engineering to the "MATHEON Workshop 2013: Compressed Sensing and its Applications” in December 2013. It was the first workshop specifically focusing on the applications of compressed sensing. This book featur...

Synthetic Self-Adjuvanting Glycopeptide Cancer Vaccines

Science.gov (United States)

Payne, Richard; McDonald, David; Byrne, Scott

2015-10-01

Due to changes in glycosyltransferase expression during tumorigenesis, the glycoproteins of cancer cells often carry highly truncated carbohydrate chains compared to those on healthy cells. These glycans are known as tumor-associated carbohydrate antigens, and are prime targets for use in vaccines for the prevention and treatment of cancer. Herein, we review the state-of-the-art in targeting the immune system towards tumor-associated glycopeptide antigens via synthetic self adjuvanting vaccines, in which the antigenic and adjuvanting moieties of the vaccines are present in the same molecule. The majority of the self-adjuvanting glycopeptide cancer vaccines reported to date employ antigens from mucin 1, a protein which is highly over-expressed and aberrantly glycosylated in many forms of cancer. The adjuvants used in these vaccines predominantly include lipopeptide- or lipoamino acid-based TLR2 agonists, although studies investigating stimulation of TLR9 and TLR4 are also discussed. Most of these adjuvants are highly lipophilic, and, upon conjugation to antigenic peptides, provide amphiphilic vaccine molecules. The amphiphilic nature of these vaccine constructs can lead to the formation of higher-order structures by vaccines in solution, which are likely to be important for their efficacy in vivo.

The Second International Workshop on Squeezed States and Uncertainty Relations

Science.gov (United States)

Han, D. (Editor); Kim, Y. S.; Manko, V. I.

1993-01-01

This conference publication contains the proceedings of the Second International Workshop on Squeezed States and Uncertainty Relations held in Moscow, Russia, on 25-29 May 1992. The purpose of this workshop was to study possible applications of squeezed states of light. The Workshop brought together many active researchers in squeezed states of light and those who may find the concept of squeezed states useful in their research, particularly in understanding the uncertainty relations. It was found at this workshop that the squeezed state has a much broader implication than the two-photon coherent states in quantum optics, since the squeeze transformation is one of the most fundamental transformations in physics.

ITER workshops demonstrate details of Canada's bid

International Nuclear Information System (INIS)

Barnard, P.

2001-01-01

On 5 and 6 November a series of five Workshops were held in Canada that provided thirty international ITER participants with significant background on various aspects of the Canadian offer. The public-private sector partnership basis for the Canadian offer is unique, and the Workshops provided an opportunity for participants from the EU, Japan and the Russian Federation to broaden their understanding of the offer and to share and discuss issues that may be relevant in the preparation of other site offers

78 FR 79469 - Strategies To Address Hemolytic Complications of Immune Globulin Infusions; Public Workshop

Science.gov (United States)

2013-12-30

... questions related to patient risk and product characteristics. The workshop has been planned in partnership... questions related to patient risk and product characteristics. The first day of this workshop will include...-associated hemolysis; (2) patient risk factors; and (3) possible product risk factors, including the presence...

Challenges and Priorities for Surveillance of Stillbirths: A Report on Two Workshops

OpenAIRE

Duke, C. Wes; Correa, Adolfo; Romitti, Paul A.; Martin, Joyce; Kirby, Russell S.

2009-01-01

Stillbirths, those with and without birth defects, are an important public health topic. The National Center on Birth Defects and Developmental Disabilities at the Centers for Disease Control and Prevention conducted two workshops during April and July 2005. Both workshops explored the challenges of conducting surveillance of stillbirths. Workshop participants considered an approach that added the surveillance of stillbirths, those with and without birth defects, as part of existing populatio...

Workshop on intakes of radionuclides: occupational and public exposure, Avignon, 15-18 September 1997

International Nuclear Information System (INIS)

Etherington, G.; Phipps, A.W.; Harrison, J.D.; Jones, D.G.; Stradling, G.N.

1998-01-01

This meeting was the fourth in this series of Workshops, previous meetings having been held in Versailles, France in 1988, in Elmau, Germany in 1991, and in Bath, UK in 1993. The Avignon meeting comes at a time of intense activity in internal dosimetry. The International Commission on Radiological Protection (ICRP) has recently completed development and publication of a series of physiologically based age-dependent biokinetic models for a range of important radionuclides. This followed the publication in 1994 of the new Human Respiratory Tract Model (HRTM). These models have now been used to determine the dose coefficients that are given in the EURATOM Directive and in the International Basic Safety Standards. A forthcoming ICRP publication will present predictions of the new models for bioassay quantities of interest, and will give revised guidance on the design and interpretation of internal dosimetry monitoring programmes. Another will give technical guidance on the use of the HRTM in practical situations. Looking further into the future, work on the development of a new age-dependent dosimetric model for the gastro-intestinal tract is now under way. With so many recent and forthcoming developments in modelling, it is not surprising that one of the unifying themes of the meeting was the impending need for internal dosimetry practitioners to be able to use the new models for assessments of doses in the workplace. The meeting's main sessions were organised under five headings: occupational exposure to radionuclides, public exposure to radionuclides, developments in modelling, physical dosimetry and treatment of accidental intakes

Spiral 2 workshop

International Nuclear Information System (INIS)

2004-01-01

The accelerator and experimental facilities at GANIL will be transformed over the next 5-10 years. The centerpiece of the additions to the accelerator complex will be Spiral-2. This is the first phase of a new radioactive beam facility based on the ISOL principle. The main aim of Spiral-2 will be to produce intense, high quality beams of neutron-rich nuclei created in neutron-induced fission of heavy elements and accelerated by the existing CIME cyclotron. The principal aims of this workshop will be a) to publicize the new facilities, b) to discuss and define the science which might be carried out with them, c) to discuss the instrumentation and infrastructure required to exploit the new facilities and d) to help form collaborations of scientists wishing to design and construct the equipment needed to undertake the science programme. This document gathers most of the slides presented in the workshop

Spiral 2 workshop

Energy Technology Data Exchange (ETDEWEB)

NONE

2004-07-01

The accelerator and experimental facilities at GANIL will be transformed over the next 5-10 years. The centerpiece of the additions to the accelerator complex will be Spiral-2. This is the first phase of a new radioactive beam facility based on the ISOL principle. The main aim of Spiral-2 will be to produce intense, high quality beams of neutron-rich nuclei created in neutron-induced fission of heavy elements and accelerated by the existing CIME cyclotron. The principal aims of this workshop will be a) to publicize the new facilities, b) to discuss and define the science which might be carried out with them, c) to discuss the instrumentation and infrastructure required to exploit the new facilities and d) to help form collaborations of scientists wishing to design and construct the equipment needed to undertake the science programme. This document gathers most of the slides presented in the workshop.

Application of “Systems Vaccinology” to Evaluate Inflammation and Reactogenicity of Adjuvanted Preventative Vaccines

Directory of Open Access Journals (Sweden)

David J. M. Lewis

2015-01-01

Full Text Available Advances in “omics” technology (transcriptomics, proteomics, metabolomics, genomics/epigenomics, etc. allied with statistical and bioinformatics tools are providing insights into basic mechanisms of vaccine and adjuvant efficacy or inflammation/reactogenicity. Predictive biomarkers of relatively frequent inflammatory reactogenicity may be identified in systems vaccinology studies involving tens or hundreds of participants and used to screen new vaccines and adjuvants in in vitro, ex vivo, animal, or human models. The identification of rare events (such as those observed with initial rotavirus vaccine or suspected autoimmune complications will require interrogation of large data sets and population-based research before application of systems vaccinology. The Innovative Medicine Initiative funded public-private project BIOVACSAFE is an initial attempt to systematically identify biomarkers of relatively common inflammatory events after adjuvanted immunization using human, animal, and population-based models. Discriminatory profiles or biomarkers are being identified, which require validation in large trials involving thousands of participants before they can be generalized. Ultimately, it is to be hoped that the knowledge gained from such initiatives will provide tools to the industry, academia, and regulators to select optimal noninflammatory but immunogenic and effective vaccine adjuvant combinations, thereby shortening product development cycles and identifying unsuitable vaccine candidates that would fail in expensive late stage development or postmarketing.

75 FR 71454 - NIJ Certification Programs Workshop

Science.gov (United States)

2010-11-23

... Workshop to introduce NIJ standards for law enforcement, corrections, and public safety equipment to....m. to 5 p.m. at the Hotel Monaco, 700 F Street, NW., Washington, DC 20004. The meeting room is the...

Novel Adjuvants and Immunomodulators for Veterinary Vaccines.

Science.gov (United States)

Heegaard, Peter M H; Fang, Yongxiang; Jungersen, Gregers

2016-01-01

Adjuvants are crucial for efficacy of vaccines, especially subunit and recombinant vaccines. Rational vaccine design, including knowledge-based and molecularly defined adjuvants tailored for directing and potentiating specific types of host immune responses towards the antigens included in the vaccine is becoming a reality with our increased understanding of innate and adaptive immune activation. This will allow future vaccines to induce immune reactivity having adequate specificity as well as protective and recallable immune effector mechanisms in appropriate body compartments, including mucosal surfaces. Here we describe these new developments and, when possible, relate new immunological knowledge to the many years of experience with traditional, empirical adjuvants. Finally, some protocols are given for production of emulsion (oil-based) and liposome-based adjuvant/antigen formulations.

Adjuvant chemotherapy and cancer cure

International Nuclear Information System (INIS)

Bertino, J.R.

1983-01-01

The use of chemotherapy as an adjuvant to surgery and/or radiotherapy is well founded in experimental tumor systems and appears to be effective in patients in some circumstances. It is clear from both clinical and experimental studies that (1) the dose is important, (2) the earlier chemotherapy is started after primary therapy the better, and (3) combination chemotherapy may be more effective than single-agent treatment. The better the estimation of risk of recurrence, the better the assessment of the risk-benefit ratio with adjuvant therapy. Salvage therapy as well as relative risk of recurrence are considerations in the choice of patients to be treated. Finally, some evidence is presented to indicate that alkylating agents may not be necessary in combination regimens for adjuvant therapy if effective antimetabolite combinations are available

77 FR 56650 - Food and Drug Administration/American Glaucoma Society Workshop on the Validity, Reliability, and...

Science.gov (United States)

2012-09-13

...] Food and Drug Administration/American Glaucoma Society Workshop on the Validity, Reliability, and... entitled ``FDA/American Glaucoma Society (AGS) Workshop on the Validity, Reliability, and Usability of... research. The purpose of this public workshop is to provide a forum for discussing the validity...

Mars exploration study workshop 2

Science.gov (United States)

Duke, Michael B.; Budden, Nancy Ann

1993-11-01

A year-long NASA-wide study effort has led to the development of an innovative strategy for the human exploration of Mars. The latest Mars Exploration Study Workshop 2 advanced a design reference mission (DRM) that significantly reduces the perceived high costs, complex infrastructure, and long schedules associated with previous Mars scenarios. This surface-oriented philosophy emphasizes the development of high-leveraging surface technologies in lieu of concentrating exclusively on space transportation technologies and development strategies. As a result of the DRM's balanced approach to mission and crew risk, element commonality, and technology development, human missions to Mars can be accomplished without the need for complex assembly operations in low-Earth orbit. This report, which summarizes the Mars Exploration Study Workshop held at the Ames Research Center on May 24-25, 1993, provides an overview of the status of the Mars Exploration Study, material presented at the workshop, and discussions of open items being addressed by the study team. The workshop assembled three teams of experts to discuss cost, dual-use technology, and international involvement, and to generate a working group white paper addressing these issues. The three position papers which were generated are included in section three of this publication.

Workshop on nuclear structure at moderate and high spin: Slide report

International Nuclear Information System (INIS)

1986-10-01

The workshop was scheduled to coincide with the beginning of operation of a number of large arrays of Compton-suppressed germanium detectors. The workshop was divided into 14 sessions containing 3 presentations each. The topics of these sessions were superdeformation, heavy rare earths, single-particle configurations, band termination, continuum properties, light rare-earths, new techniques, high temperatures, transfer reactions, transition region, shapes, lifetimes, and moments. This publication consists of the slides used in all of the presentations at the workshop

Bioproducts to Enable Biofuels Workshop Summary Report

Energy Technology Data Exchange (ETDEWEB)

Bailey, Andrea [Office of Energy Efficiency and Renewable Energy (EERE), Washington, DC (United States); Leong, G. Jeremy [Office of Energy Efficiency and Renewable Energy (EERE), Washington, DC (United States); Fitzgerald, Nichole [Office of Energy Efficiency and Renewable Energy (EERE), Washington, DC (United States)

2015-12-01

This report summarizes the results of a public workshop sponsored by DOE/EERE in Westminster, Colorado, on July 16, 2015. The views and opinions of the workshop attendees, as summarized in this document, do not necessarily reflect those of the United States government or any agency thereof, nor do their employees make any warranty, expressed or implied, or assume any liability or responsibility for the accuracy, completeness, or usefulness of any information, apparatus, product, or process disclosed, or represent that its use would not infringe upon privately owned rights.

Seventeenth workshop on geothermal reservoir engineering: Proceedings

Energy Technology Data Exchange (ETDEWEB)

Ramey, H.J. Jr.; Kruger, P.; Miller, F.G.; Horne, R.N.; Brigham, W.E.; Cook, J.W. (Stanford Geothermal Program)

1992-01-31

PREFACE The Seventeenth Workshop on Geothermal Reservoir Engineering was held at Stanford University on January 29-31, 1992. There were one hundred sixteen registered participants which equaled the attendance last year. Participants were from seven foreign countries: Italy, Japan, United Kingdom, France, Belgium, Mexico and New Zealand. Performance of many geothermal fields outside the United States was described in the papers. The Workshop Banquet Speaker was Dr. Raffaele Cataldi. Dr. Cataldi gave a talk on the highlights of his geothermal career. The Stanford Geothermal Program Reservoir Engineering Award for Excellence in Development of Geothermal Energy was awarded to Dr. Cataldi. Dr. Frank Miller presented the award at the banquet. Thirty-eight papers were presented at the Workshop with two papers submitted for publication only. Dr. Roland Horne opened the meeting and the key note speaker was J.E. ''Ted'' Mock who discussed the DOE Geothermal R. & D. Program. The talk focused on aiding long-term, cost effective private resource development. Technical papers were organized in twelve sessions concerning: geochemistry, hot dry rock, injection, geysers, modeling, and reservoir mechanics. Session chairmen were major contributors to the program and we thank: Sabodh Garg., Jim Lovekin, Jim Combs, Ben Barker, Marcel Lippmann, Glenn Horton, Steve Enedy, and John Counsil. The Workshop was organized by the Stanford Geothermal Program faculty, staff, and graduate students. We wish to thank Pat Ota, Ted Sumida, and Terri A. Ramey who also produces the Proceedings Volumes for publication. We owe a great deal of thanks to our students who operate audiovisual equipment and to Francois Groff who coordinated the meeting arrangements for the Workshop. Henry J. Ramey, Jr. Roland N. Horne Frank G. Miller Paul Kruger William E. Brigham Jean W. Cook -vii

UVI Cyber-security Workshop Workshop Analysis.

Energy Technology Data Exchange (ETDEWEB)

Kuykendall, Tommie G. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Allsop, Jacob Lee [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Anderson, Benjamin Robert [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Boumedine, Marc [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Carter, Cedric [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Galvin, Seanmichael Yurko [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Gonzalez, Oscar [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Lee, Wellington K. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Lin, Han Wei [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Morris, Tyler Jake [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Nauer, Kevin S.; Potts, Beth A.; Ta, Kim Thanh; Trasti, Jennifer; White, David R.

2015-07-08

The cybersecurity consortium, which was established by DOE/NNSA’s Minority Serving Institutions Partnerships Program (MSIPP), allows students from any of the partner schools (13 HBCUs, two national laboratories, and a public school district) to have all consortia options available to them, to create career paths and to open doors to DOE sites and facilities to student members of the consortium. As a part of this year consortium activities, Sandia National Laboratories and the University of Virgin Islands conducted a week long cyber workshop that consisted of three courses; Digital Forensics and Malware Analysis, Python Programming, and ThunderBird Cup. These courses are designed to enhance cyber defense skills and promote learning within STEM related fields.

NEA Workshop on Stakeholder Involvement in Nuclear Decision Making. Summary Report

International Nuclear Information System (INIS)

Haage, Monica; Henderson, David; Mays, Claire

2017-01-01

The present report summarises the NEA workshop proceedings. Chapter 1 recalls the setting in which the 2017 workshop was organised, the development of the workshop and the audience it gathered. Subsequent chapters are based on rapporteurs' accounts of the plenary and keynote talks (Chapter 2) and topical presentations (Chapter 3), as well as the dialogues among attendees which were then reported in plenary (Chapter 4). Quotes highlighted throughout the report were drawn from speakers' material or from the dialogues. In this way the publication reports the kaleidoscope of views and practices brought by NEA member countries and their experts from almost all nuclear areas as well as from some other energy technology sectors. It documents best practice and lessons learnt. Furthermore, Chapter 5 singles out the commonalities and differences found across the countries and sectors, as well as tangible take-away from the workshop. The reader will find that certain major messages are repeated in different parts of the report, as a sign of the convergence between different contexts, experts, sessions and discussions. Chapter 6 reports the attendees' evaluation of the workshop and the actions requested to progress. The annexes provide further resources: other NEA publications of interest; instructions for facilitating dialogue; and the list of participants

WWER-1000 reactor simulator. Material for training courses and workshops. 2. ed

International Nuclear Information System (INIS)

2005-01-01

The International Atomic Energy Agency (IAEA) has established an activity in nuclear reactor simulation computer programs to assist its Member States in education. The objective is to provide, for a variety of advanced reactor types, insight and practice in their operational characteristics and their response to perturbations and accident situations. To achieve this, the IAEA arranges for the development and distribution of simulation programs and educational material and sponsors courses and workshops. The workshops are in two parts: techniques and tools for reactor simulator development; and the use of reactor simulators in education. Workshop material for the first part is covered in the IAEA publication: Training Course Series No.12, Reactor Simulator Development (2001). Course material for workshops using a pressurized water reactor (PWR) simulator developed for the IAEA by Cassiopeia Technologies Inc. of Canada is presented in the IAEA publication, Training Course Series No. 22, 2nd edition, Pressurized Water Reactor Simulator (2005) and Training Course Series No.23, 2nd edition, Boiling Water Reactor Simulator (2005). This report consists of course material for workshops using the WWER-1000 Reactor Department Simulator from the Moscow Engineering and Physics Institute, Russian Federation

Modern Vaccines/Adjuvants Formulation—Session 2 (Plenary II)

Science.gov (United States)

Collin, Nicolas

2013-01-01

On the 15–17th May 2013, the Fourth International Conference on Modern Vaccines/Adjuvants Formulation was organized in Lausanne, Switzerland, and gathered stakeholders from academics and from the industry to discuss several challenges, advances and promises in the field of vaccine adjuvants. Plenary session 2 of the meeting was composed of four different presentations covering: (1) the recent set-up of an adjuvant technology transfer and training platform in Switzerland, (2) the proposition to revisit existing paradigms of modern vaccinology, (3) the properties of polyethyleneimine as potential new vaccine adjuvant, and (4) the progresses in the design of HIV vaccine candidates able to induce broadly neutralizing antibodies. PMID:23966098

Pressurized water reactor simulator. Workshop material. 2. ed

International Nuclear Information System (INIS)

2005-01-01

The International Atomic Energy Agency (IAEA) has established an activity in nuclear reactor simulation computer programs to assist its Member States in education. The objective is to provide, for a variety of advanced reactor types, insight and practice in their operational characteristics and their response to perturbations and accident situations. To achieve this, the IAEA arranges for the development and distribution of simulation programs and educational material and sponsors courses and workshops. The workshops are in two parts: techniques and tools for reactor simulator development. And the use of reactor simulators in education. Workshop material for the first part is covered in the IAEA Training Course Series No. 12, 'Reactor Simulator Development' (2001). Course material for workshops using a WWER- 1000 reactor department simulator from the Moscow Engineering and Physics Institute, the Russian Federation is presented in the IAEA Training Course Series No. 21, 2nd edition, 'WWER-1000 Reactor Simulator' (2005). Course material for workshops using a boiling water reactor simulator developed for the IAEA by Cassiopeia Technologies Incorporated of Canada (CTI) is presented in the IAEA publication: Training Course Series No.23, 2nd edition, 'Boiling Water Reactor Simulator' (2005). This report consists of course material for workshops using a pressurized water reactor simulator

Nineteenth workshop on geothermal reservoir engineering: Proceedings

Energy Technology Data Exchange (ETDEWEB)

Ramey, H.J. Jr.; Horne, R.J.; Kruger, P.; Miller, F.G.; Brigham, W.E.; Cook, J.W. (Stanford Geothermal Program)

1994-01-20

PREFACE The Nineteenth Workshop on Geothermal Reservoir Engineering was held at Stanford University on January 18-20, 1994. This workshop opened on a sad note because of the death of Prof. Henry J. Ramey, Jr. on November 19, 1993. Hank had been fighting leukemia for a long time and finally lost the battle. Many of the workshop participants were present for the celebration of his life on January 21 at Stanford's Memorial Church. Hank was one of the founders of the Stanford Geothermal Program and the Geothermal Reservoir Engineering Workshop. His energy, kindness, quick wit, and knowledge will long be missed at future workshops. Following the Preface we have included a copy of the Memorial Resolution passed by the Stanford University Senate. There were one hundred and four registered participants. Participants were from ten foreign countries: Costa Rica, England, Iceland, Italy, Japan, Kenya, Mexico, New Zealand, Philippines and Turkey. Workshop papers described the performance of fourteen geothermal fields outside the United States. Roland N. Home opened the meeting and welcomed the visitors to the campus. The key note speaker was J.E. ''Ted'' Mock who gave a presentation about the future of geothermal development. The banquet speaker was Jesus Rivera and he spoke about Energy Sources of Central American Countries. Forty two papers were presented at the Workshop. Technical papers were organized in twelve sessions concerning: sciences, injection, production, modeling, and adsorption. Session chairmen are an important part of the workshop and our thanks go to: John Counsil, Mark Walters, Dave Duchane, David Faulder, Gudmundur Bodvarsson, Jim Lovekin, Joel Renner, and Iraj Ershaghi. The Workshop was organized by the Stanford Geothermal Program faculty, staff, and graduate students. We wish to thank Pat Ota, Ted Sumida, and Terri A. Ramey who also produces the Proceedings Volumes for publication. We owe a great deal of thanks to our students who

Adjuvant radiation for vulvar carcinoma: improved local control

International Nuclear Information System (INIS)

Faul, Clare M.; Mirmow, Dwight; Huang Qingshon; Gerszten, Kristina; Day, Roger; Jones, Mirka W.

1997-01-01

Purpose: Local recurrence is a significant problem following primary surgery for advanced vulva carcinoma. The objectives of this study were to evaluate the impact of adjuvant vulvar radiation on local control in high risk patients and the impact of local recurrence on overall survival. Methods and Materials: From 1980-1994, 62 patients with invasive vulva carcinoma and either positive or close (less 8 mm) margins of excision were retrospectively studied. Thirty-one patients were treated with adjuvant radiation therapy to the vulva and 31 patients were observed after surgery. Kaplan-Meier estimates and the Cox proportional hazard regression model were used to evaluate the effect of adjuvant radiation therapy on local recurrence and overall survival. Independent prognostic factors for local recurrence and survival were also assessed. Results: Local recurrence occurred in 58% of observed patients and 16% in patients treated with adjuvant radiation therapy. Adjuvant radiation therapy significantly reduced local recurrence rates in both the close margin and positive margin groups (p = 0.036, p = 0.0048). On both univariate and multivariate analysis adjuvant radiation and margins of excision were significant prognostic predictors for local control. Significant determinants of actuarial survival included International Federation of Gynecologists and Obstetricians (FIGO) stage, percentage of pathologically positive inguinal nodes and margins of excision. The positive margin observed group had a significantly poorer actuarial 5 year survival than the other groups (p = 0.0016) and adjuvant radiation significantly improved survival for this group. The 2 year actuarial survival after developing local recurrence was 25%. Local recurrence was a significant predictor for death from vulva carcinoma (risk ratio 3.54). Conclusion: Local recurrence is a common occurrence in high risk patients. In this study adjuvant radiation therapy significantly reduced local recurrence rates and

An update on safety and immunogenicity of vaccines containing emulsion-based adjuvants.

Science.gov (United States)

Fox, Christopher B; Haensler, Jean

2013-07-01

With the exception of alum, emulsion-based vaccine adjuvants have been administered to far more people than any other adjuvant, especially since the 2009 H1N1 influenza pandemic. The number of clinical safety and immunogenicity evaluations of vaccines containing emulsion adjuvants has correspondingly mushroomed. In this review, the authors introduce emulsion adjuvant composition and history before detailing the most recent findings from clinical and postmarketing data regarding the effects of emulsion adjuvants on vaccine immunogenicity and safety, with emphasis on the most widely distributed emulsion adjuvants, MF59® and AS03. The authors also present a summary of other emulsion adjuvants in clinical development and indicate promising avenues for future emulsion-based adjuvant development. Overall, emulsion adjuvants have demonstrated potent adjuvant activity across a number of disease indications along with acceptable safety profiles.

76 FR 50231 - Mobile Medical Applications Draft Guidance; Public Workshop

Science.gov (United States)

2011-08-12

... workshop discussion, a ``mobile medical app'' is a mobile application that meets the definition of ``device... applications are subject to regulation as devices when they meet the definition of a device in section 201(h... man * * * '' or ``* * * intended to affect the structure or any function of the body of man or other...

77 FR 50469 - Notice of Public Workshop: “Designing for Impact III: Workshop on Building the National Network...

Science.gov (United States)

2012-08-21

...-president-manufacturing-and-economy . The Designing for Impact workshop series is organized by the federal... regional manufacturing and ensuring that our manufacturing sector is a key pillar in an economy that is... initiative to facilitate collaboration and information sharing across federal agencies. \\2\\ http://www...

Overview of Vaccine Adjuvants: Introduction, History, and Current Status.

Science.gov (United States)

Shah, Ruchi R; Hassett, Kimberly J; Brito, Luis A

2017-01-01

Adjuvants are included in sub-unit or recombinant vaccines to enhance the potency of poorly immunogenic antigens. Adjuvant discovery is as complex as it is a multidiscplinary intersection of formulation science, immunology, toxicology, and biology. Adjuvants such as alum, which have been in use for the past 90 years, have illustrated that adjuvant research is a methodical process. As science advances, new analytical tools are developed which allows us to delve deeper into the various mechanisms that generates a potent immune response. Additionally, these new techniques help the field learn about our existing vaccines and what makes them safe, and effective, allowing us to leverage that in the next generation of vaccines. Our goal in this chapter is to define the concept, need, and mechanism of adjuvants in the vaccine field while describing its history, present use, and future prospects. More details on individual adjuvants and their formulation, development, mechanism, and use will be covered in depth in the next chapters.

Does lipophilicity per se induce adjuvant effects?

DEFF Research Database (Denmark)

Hansen, Jitka Stilund; Larsen, Søren Thor; Poulsen, Lars K.

2007-01-01

Anthopogenically introduced substances and pollutants are suspected to promote sensitization and development of allergic airway diseases, that is, acting as adjuvants. Lipophilicity may serve as an immunological warning signal, promoting adjuvant effects. Whether the lipophilicity of an inhaled...... respiratory patterns were significantly affected in the MP groups. The OVA + Al(OH)3 group had a significantly higher IgG1 and IgE production, as well as higher eosinophil infiltration in the BAL fluid. These studies showed that effects of adjuvants not are necessarily due to their lipophilicity; that is...

Novel Adjuvants and Immunomodulators for Veterinary Vaccines

DEFF Research Database (Denmark)

Heegaard, Peter M. H.; Fang, Yongxiang; Jungersen, Gregers

2016-01-01

Adjuvants are crucial for efficacy of vaccines, especially subunit and recombinant vaccines. Rational vaccine design, including knowledge-based and molecularly defined adjuvants tailored for directing and potentiating specific types of host immune responses towards the antigens included in the va...

Antibody-antigen-adjuvant conjugates enable co-delivery of antigen and adjuvant to dendritic cells in cis but only have partial targeting specificity.

Directory of Open Access Journals (Sweden)

Martin Kreutz

Full Text Available Antibody-antigen conjugates, which promote antigen-presentation by dendritic cells (DC by means of targeted delivery of antigen to particular DC subsets, represent a powerful vaccination approach. To ensure immunity rather than tolerance induction the co-administration of a suitable adjuvant is paramount. However, co-administration of unlinked adjuvant cannot ensure that all cells targeted by the antibody conjugates are appropriately activated. Furthermore, antigen-presenting cells (APC that do not present the desired antigen are equally strongly activated and could prime undesired responses against self-antigens. We, therefore, were interested in exploring targeted co-delivery of antigen and adjuvant in cis in form of antibody-antigen-adjuvant conjugates for the induction of anti-tumour immunity. In this study, we report on the assembly and characterization of conjugates consisting of DEC205-specific antibody, the model antigen ovalbumin (OVA and CpG oligodeoxynucleotides (ODN. We show that such conjugates are more potent at inducing cytotoxic T lymphocyte (CTL responses than control conjugates mixed with soluble CpG. However, our study also reveals that the nucleic acid moiety of such antibody-antigen-adjuvant conjugates alters their binding and uptake and allows delivery of the antigen and the adjuvant to cells partially independently of DEC205. Nevertheless, antibody-antigen-adjuvant conjugates are superior to antibody-free antigen-adjuvant conjugates in priming CTL responses and efficiently induce anti-tumour immunity in the murine B16 pseudo-metastasis model. A better understanding of the role of the antibody moiety is required to inform future conjugate vaccination strategies for efficient induction of anti-tumour responses.

Workshops Without Walls: broadening access to science around the world.

Directory of Open Access Journals (Sweden)

Betül K Arslan

2011-08-01

Full Text Available The National Aeronautics and Space Administration (NASA Astrobiology Institute (NAI conducted two "Workshops Without Walls" during 2010 that enabled global scientific exchange--with no travel required. The second of these was on the topic "Molecular Paleontology and Resurrection: Rewinding the Tape of Life." Scientists from diverse disciplines and locations around the world were joined through an integrated suite of collaborative technologies to exchange information on the latest developments in this area of origin of life research. Through social media outlets and popular science blogs, participation in the workshop was broadened to include educators, science writers, and members of the general public. In total, over 560 people from 31 US states and 30 other nations were registered. Among the scientific disciplines represented were geochemistry, biochemistry, molecular biology and evolution, and microbial ecology. We present this workshop as a case study in how interdisciplinary collaborative research may be fostered, with substantial public engagement, without sustaining the deleterious environmental and economic impacts of travel.

Towards an understanding of the adjuvant action of aluminium

Science.gov (United States)

Marrack, Philippa; McKee, Amy S.; Munks, Michael W.

2011-01-01

The efficacy of vaccines depends on the presence of an adjuvant in conjunction with the antigen. Of these adjuvants, the ones that contain aluminium, which were first discovered empirically in 1926, are currently the most widely used. However, a detailed understanding of their mechanism of action has only started to be revealed. In this Timeline article, we briefly describe the initial discovery of aluminium adjuvants and discuss historically important advances. We also summarize recent progress in the field and discuss their implications and the remaining questions on how these adjuvants work. PMID:19247370

Workshops som forskningsmetode

OpenAIRE

Ørngreen, Rikke; Levinsen, Karin Tweddell

2017-01-01

This paper contributes to knowledge on workshops as a research methodology, and specifically on how such workshops pertain to e-learning. A literature review illustrated that workshops are discussed according to three different perspectives: workshops as a means, workshops as practice, and workshops as a research methodology. Focusing primarily on the latter, this paper presents five studies on upper secondary and higher education teachers’ professional development and on teaching and learnin...

Helping Youth Decide: A Workshop Guide.

Science.gov (United States)

Duquette, Donna Marie; Boo, Katherine

This guide was written to complement the publication "Helping Youth Decide," a manual designed to help parents develop effective parent-child communication and help their children make responsible decisions during the adolescent years. The workshop guide is intended to assist people who work with families to provide additional information and…

Proceedings of the 2nd workshop on information management

International Nuclear Information System (INIS)

Hoepfner, K.A.

1992-03-01

As a practical result of this workshop it is expected that the possibilities for the acquisition of information become more transparent. From the point of view of the authorities this would be of special interest in the field of safety evaluations, on the regulatory level, and for the work of the press and public relations. The wish has been fulfilled to invite to this workshop the information experts competent in the specialist area. This means that at the end of this workshop a qualified survey over existing information sources will be available. All this is of vital importance for effective information management of the topic areas of nuclear safety, radiation protection and environmental protection. (orig./DG)

Adjuvants for vaccines to drugs of abuse and addiction.

Science.gov (United States)

Alving, Carl R; Matyas, Gary R; Torres, Oscar; Jalah, Rashmi; Beck, Zoltan

2014-09-22

Immunotherapeutic vaccines to drugs of abuse, including nicotine, cocaine, heroin, oxycodone, methamphetamine, and others are being developed. The theoretical basis of such vaccines is to induce antibodies that sequester the drug in the blood in the form of antibody-bound drug that cannot cross the blood brain barrier, thereby preventing psychoactive effects. Because the drugs are haptens a successful vaccine relies on development of appropriate hapten-protein carrier conjugates. However, because induction of high and prolonged levels of antibodies is required for an effective vaccine, and because injection of T-independent haptenic drugs of abuse does not induce memory recall responses, the role of adjuvants during immunization plays a critical role. As reviewed herein, preclinical studies often use strong adjuvants such as complete and incomplete Freund's adjuvant and others that cannot be, or in the case of many newer adjuvants, have never been, employed in humans. Balanced against this, the only adjuvant that has been included in candidate vaccines in human clinical trials to nicotine and cocaine has been aluminum hydroxide gel. While aluminum salts have been widely utilized worldwide in numerous licensed vaccines, the experience with human responses to aluminum salt-adjuvanted vaccines to haptenic drugs of abuse has suggested that the immune responses are too weak to allow development of a successful vaccine. What is needed is an adjuvant or combination of adjuvants that are safe, potent, widely available, easily manufactured, and cost-effective. Based on our review of the field we recommend the following adjuvant combinations either for research or for product development for human use: aluminum salt with adsorbed monophosphoryl lipid A (MPLA); liposomes containing MPLA [L(MPLA)]; L(MPLA) adsorbed to aluminum salt; oil-in-water emulsion; or oil-in-water emulsion containing MPLA. Copyright © 2014. Published by Elsevier Ltd.

International development workshops. Final technical report

International Nuclear Information System (INIS)

1997-01-01

The US Department of Energy (DOE) and the Nuclear Energy Agency of the Organization for Economic Cooperation and Development/Nuclear Energy Agency (OECD/NEA) began to act on their recognition of the importance of education in nuclear literacy, specifically in radioactive waste management (RWM), several years ago. To address this Goal for nuclear literacy, the US DOE; through the Information and Education Division of the Office of Civilian Radioactive Waste Management (OCRWM) and in cooperation with the OECD/NEA, organized an ''International Workshop on Education in the Field of Radioactive Waste Management'' in Engelberg, Switzerland in June of 1991. To this end, a grant to support nuclear literacy and RWM was written and funded by the OCRWM and the education division of the DOE Yucca Mountain Office in 1990. The over-riding Goal of that workshop and the DOE grant was to find ways of raising the level of nuclear literacy in the general public through educational programs in radioactive waste management (RWM). The two Main Objectives of the workshop were: first, to contribute to an information base for education systems, on global aspects of radioactive waste management; and second, to achieve international consensus on the basic tools and methods required to develop the information base. These two objectives also became the principal objectives of the DOE International Workshops grant. In other words, the global and local (Nevada) objectives were one and the same. Workshop overviews and accomplishments are summarized in this report

International development workshops. Final technical report

Energy Technology Data Exchange (ETDEWEB)

NONE

1997-08-06

The US Department of Energy (DOE) and the Nuclear Energy Agency of the Organization for Economic Cooperation and Development/Nuclear Energy Agency (OECD/NEA) began to act on their recognition of the importance of education in nuclear literacy, specifically in radioactive waste management (RWM), several years ago. To address this Goal for nuclear literacy, the US DOE; through the Information and Education Division of the Office of Civilian Radioactive Waste Management (OCRWM) and in cooperation with the OECD/NEA, organized an ``International Workshop on Education in the Field of Radioactive Waste Management`` in Engelberg, Switzerland in June of 1991. To this end, a grant to support nuclear literacy and RWM was written and funded by the OCRWM and the education division of the DOE Yucca Mountain Office in 1990. The over-riding Goal of that workshop and the DOE grant was to find ways of raising the level of nuclear literacy in the general public through educational programs in radioactive waste management (RWM). The two Main Objectives of the workshop were: first, to contribute to an information base for education systems, on global aspects of radioactive waste management; and second, to achieve international consensus on the basic tools and methods required to develop the information base. These two objectives also became the principal objectives of the DOE International Workshops grant. In other words, the global and local (Nevada) objectives were one and the same. Workshop overviews and accomplishments are summarized in this report.

Production, purification and immunogenicity of recombinant Ebola virus proteins - A comparison of Freund's adjuvant and adjuvant system 03.

Science.gov (United States)

Melén, Krister; Kakkola, Laura; He, Felix; Airenne, Kari; Vapalahti, Olli; Karlberg, Helen; Mirazimi, Ali; Julkunen, Ilkka

2017-04-01

There is an urgent need for Ebola virus (EBOV) proteins, EBOV-specific antibodies and recombinant antigens to be used in diagnostics and as potential vaccine candidates. Our objective was to produce and purify recombinant proteins for immunological assays and for the production of polyclonal EBOV specific antibodies. In addition, a limited comparison of the adjuvant effects of Freund's complete adjuvant (FCA) and adjuvant system 03 (AS03) was carried out. Recombinant EBOV GST-VP24, -VP30, -VP35, -VP40 and -NP were produced in E. coli and purified with affinity chromatography followed by preparative gel electrophoresis. Recombinant EBOV GP-His was produced in Sf9 insect cells and purified by preparative gel electrophoresis. To compare the adjuvant effect of FCA and AS03, 12 rabbits were immunized four times with one of the six recombinant EBOV proteins using FCA or AS03. In addition, three guinea pigs were immunized with EBOV VP24 using FCA. With the exception of sera from two rabbits immunized with GST-VP24, the antisera against all other EBOV proteins showed very high and specific antibody responses after three to four immunizations. The adjuvant effect of AS03 was comparable to that of FCA. The produced antibodies recognized the corresponding EBOV proteins in wild type EBOV-infected cells. Copyright © 2016 Elsevier B.V. All rights reserved.

Immunomodulators as adjuvants for vaccines and antimicrobial therapy.

Science.gov (United States)

Nicholls, Erin F; Madera, Laurence; Hancock, Robert E W

2010-12-01

A highly effective strategy for combating infectious diseases is to enhance host defenses using immunomodulators, either preventatively, through vaccination, or therapeutically. The effectiveness of many vaccines currently in use is due in part to adjuvants, molecules that have little immunogenicity by themselves but which help enhance and appropriately skew the immune response to an antigen. The development of new vaccines necessitates the development of new types of adjuvants to ensure an appropriate immune response. Herein, we review commonly used vaccine adjuvants and discuss promising adjuvant candidates. We also discuss various other immunomodulators (namely cytokines, Toll-like receptor agonists, and host defense peptides) that are, or have potential to be, useful for antimicrobial therapies that exert their effects by boosting host immune responses rather than targeting pathogens directly.

Developing public affairs counseling skills to support a public participation focus at Fernald

Energy Technology Data Exchange (ETDEWEB)

Hoopes, J. [Fernald Environmental Restoration Management Corp., Cincinnati, OH (United States)

1994-03-01

To provide closer coordination between the Public Affairs Division and environmental restoration management and technical staff, the Fernald Environmental Restoration Management Corporation (FERMCO) matrixed Public Affairs staffers as counselors to project teams within FERMCO. Close coordination between technical staff and public affairs staff is essential for effective public communication in a public participation, environmental risk communication environment. Two-way symmetrical communication (public participation) represents a paradigm shift for public affairs staff who have developed skills primarily in a public information (asymmetrical communication) environment. While there has been much focus in the literature and workshops on management changes needed to support a public participation environment, less attention has been paid to identifying and developing the skills needed by public affairs professionals to support public participation. To support the new counseling role of public affairs staffers, FERMCO used a public affairs training consultant to design and deliver a workshop to initiate development of the skills needed for the public affairs counseling role. This paper describes FERMCO`s matrixed counseling program and the training to develop public affairs counseling skills for the public participation environment.

NASA LaRC Workshop on Guidance, Navigation, Controls, and Dynamics for Atmospheric Flight, 1993

Science.gov (United States)

Buttrill, Carey S. (Editor)

1993-01-01

This publication is a collection of materials presented at a NASA workshop on guidance, navigation, controls, and dynamics (GNC&D) for atmospheric flight. The workshop was held at the NASA Langley Research Center on March 18-19, 1993. The workshop presentations describe the status of current research in the GNC&D area at Langley over a broad spectrum of research branches. The workshop was organized in eight sessions: overviews, general, controls, military aircraft, dynamics, guidance, systems, and a panel discussion. A highlight of the workshop was the panel discussion which addressed the following issue: 'Direction of guidance, navigation, and controls research to ensure U.S. competitiveness and leadership in aerospace technologies.'

House dust extracts contain potent immunological adjuvants

NARCIS (Netherlands)

Beukelman, C.J.; Dijk, H. van; Aerts, P.C.; Rademaker, P.M.; Berrens, L.; Willers, J.M.N.

1987-01-01

A crude aqueous extract of house dust and two house dust subfractions were tested for adjuvant activity in a sensitivity assay performed in mice. Evidence is presented that house dust contains at least two potent immunological adjuvants. One of these, present in both subfractions, was probably

Building Strong Geoscience Departments Through the Visiting Workshop Program

Science.gov (United States)

Ormand, C. J.; Manduca, C. A.; Macdonald, H.; Bralower, T. J.; Clemens-Knott, D.; Doser, D. I.; Feiss, P. G.; Rhodes, D. D.; Richardson, R. M.; Savina, M. E.

2011-12-01

points. Workshops resulted in changes in faculty attitudes and planned changes in programming. Participants wrote that they felt a greater ownership of their curricula and had a deeper understanding of the importance of general education offerings; they recognized a need for improvement; and they recognized a need to communicate the value of the geosciences to their institutions. Planned programmatic changes focused on curriculum revision, program assessment, student recruitment, and interactions with the institutional administration and the public. Leaders noted that the most effective workshops were those where the faculty cancelled all other activities for the duration of the workshop to focus on workshop goals.

HTTR workshop (workshop on hydrogen production technology)

International Nuclear Information System (INIS)

Shiina, Yasuaki; Takizuka, Takakazu

2004-12-01

Various research and development efforts have been performed to solve the global energy and environmental problems caused by large consumption of fossil fuels. Research activities on advanced hydrogen production technology by the use of nuclear heat from high temperature gas cooled reactors, for example, have been flourished in universities, research institutes and companies in many countries. The Department of HTTR Project and the Department of Advanced Nuclear Heat Technology of JAERI held the HTTR Workshop (Workshop on Hydrogen Production Technology) on July 5 and 6, 2004 to grasp the present status of R and D about the technology of HTGR and the nuclear hydrogen production in the world and to discuss about necessity of the nuclear hydrogen production and technical problems for the future development of the technology. More than 110 participants attended the Workshop including foreign participants from USA, France, Korea, Germany, Canada and United Kingdom. In the Workshop, the presentations were made on such topics as R and D programs for nuclear energy and hydrogen production technologies by thermo-chemical or other processes. Also, the possibility of the nuclear hydrogen production in the future society was discussed. The workshop showed that the R and D for the hydrogen production by the thermo-chemical process has been performed in many countries. The workshop affirmed that nuclear hydrogen production could be one of the competitive supplier of hydrogen in the future. The second HTTR Workshop will be held in the autumn next year. (author)

Mechanistic Oral Absorption Modeling and Simulation for Formulation Development and Bioequivalence Evaluation: Report of an FDA Public Workshop.

Science.gov (United States)

Zhang, X; Duan, J; Kesisoglou, F; Novakovic, J; Amidon, G L; Jamei, M; Lukacova, V; Eissing, T; Tsakalozou, E; Zhao, L; Lionberger, R

2017-08-01

On May 19, 2016, the US Food and Drug Administration (FDA) hosted a public workshop, entitled "Mechanistic Oral Absorption Modeling and Simulation for Formulation Development and Bioequivalence Evaluation." The topic of mechanistic oral absorption modeling, which is one of the major applications of physiologically based pharmacokinetic (PBPK) modeling and simulation, focuses on predicting oral absorption by mechanistically integrating gastrointestinal transit, dissolution, and permeation processes, incorporating systems, active pharmaceutical ingredient (API), and the drug product information, into a systemic mathematical whole-body framework. © 2017 The Authors CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics.

Public key infrastructure for DOE security research

Energy Technology Data Exchange (ETDEWEB)

Aiken, R.; Foster, I.; Johnston, W.E. [and others

1997-06-01

This document summarizes the Department of Energy`s Second Joint Energy Research/Defence Programs Security Research Workshop. The workshop, built on the results of the first Joint Workshop which reviewed security requirements represented in a range of mission-critical ER and DP applications, discussed commonalties and differences in ER/DP requirements and approaches, and identified an integrated common set of security research priorities. One significant conclusion of the first workshop was that progress in a broad spectrum of DOE-relevant security problems and applications could best be addressed through public-key cryptography based systems, and therefore depended upon the existence of a robust, broadly deployed public-key infrastructure. Hence, public-key infrastructure ({open_quotes}PKI{close_quotes}) was adopted as a primary focus for the second workshop. The Second Joint Workshop covered a range of DOE security research and deployment efforts, as well as summaries of the state of the art in various areas relating to public-key technologies. Key findings were that a broad range of DOE applications can benefit from security architectures and technologies built on a robust, flexible, widely deployed public-key infrastructure; that there exists a collection of specific requirements for missing or undeveloped PKI functionality, together with a preliminary assessment of how these requirements can be met; that, while commercial developments can be expected to provide many relevant security technologies, there are important capabilities that commercial developments will not address, due to the unique scale, performance, diversity, distributed nature, and sensitivity of DOE applications; that DOE should encourage and support research activities intended to increase understanding of security technology requirements, and to develop critical components not forthcoming from other sources in a timely manner.

Ninth workshop on geothermal reservoir engineering: Proceedings

Energy Technology Data Exchange (ETDEWEB)

Ramey, H.J. Jr.; Kruger, P.; Miller, F.G.; Horne, R.N.; Brigham, W.E.; Gudmundsson, J.S. (Stanford Geothermal Program)

1983-12-15

The attendance at the Workshop was similar to last year's with 123 registered participants of which 22 represented 8 foreign countries. A record number of technical papers (about 60) were submitted for presentation at the Workshop. The Program Committee, therefore, decided to have several parallel sessions to accommodate most of the papers. This format proved unpopular and will not be repeated. Many of the participants felt that the Workshop lost some of its unique qualities by having parallel sessions. The Workshop has always been held near the middle of December during examination week at Stanford. This timing was reviewed in an open discussion at the Workshop. The Program Committee subsequently decided to move the Workshop to January. The Tenth Workshop will be held on January 22-24, 1985. The theme of the Workshop this year was ''field developments worldwide''. The Program Committee addressed this theme by encouraging participants to submit field development papers, and by inviting several international authorities to give presentations at the Workshop. Field developments in at least twelve countries were reported: China, El Salvador, France, Greece, Iceland, Italy, Japan, Kenya, Mexico, New Zealand, the Philippines, and the United States. There were 58 technical presentations at the Workshop, of which 4 were not made available for publication. Several authors submitted papers not presented at the Workshop. However, these are included in the 60 papers of these Proceedings. The introductory address was given by Ron Toms of the U.S. Department of Energy, and the banquet speaker was A1 Cooper of Chevron Resources Company. An important contribution was made to the Workshop by the chairmen of the technical sessions. Other than Stanford Geothermal Program faculty members, they included: Don White (Field Developments), Bill D'Olier (Hydrothermal Systems), Herman Dykstra (Well Testing), Karsten Pruess (Well Testing), John Counsil

Proceedings of the geosciences workshop

Energy Technology Data Exchange (ETDEWEB)

None

1991-01-01

The manuscripts in these proceedings represent current understanding of geologic issues associated with the Weldon Spring Site Remedial Action Project (WSSRAP). The Weldon Spring site is in St. Charles County, Missouri. The proceedings are the record of the information presented during the WSSRAP Geosciences Workshop conducted on February 21, 1991. The objective of the workshop and proceedings is to provide the public and scientific community with technical information that will facilitate a common understanding of the geology of the Weldon Spring site, of the studies that have been and will be conducted, and of the issues associated with current and planned activities at the site. This coverage of geologic topics is part of the US Department of Energy overall program to keep the public fully informed of the status of the project and to address public concerns as we clean up the site and work toward the eventual release of the property for use by this and future generations. Papers in these proceedings detail the geology and hydrology of the site. The mission of the WSSRAP derives from the US Department of Energy's Surplus Facilities Management Program. The WSSRAP will eliminate potential hazards to the public and the environment and make surplus real property available for other uses to the extent possible. This will be accomplished by conducting remedial actions which will place the quarry, the raffinate pits, the chemical plant, and the vicinity properties in a radiologically and chemically safe condition. The individual papers have been catalogued separately.

The Astronomy Workshop

Science.gov (United States)

Hamilton, D. P.

2005-05-01

The Astronomy Workshop (http://janus.astro.umd.edu) is a collection of interactive online educational tools developed for use by students, educators, and the general public. The more than 20 tools in the Astronomy Workshop are rated for ease-of-use, and have been extensively tested in large university survey courses, classes for undergraduate majors, and High Schools. Here we briefly describe a few of the more popular tools. The Life of the Sun (New!): The history of the Sun is animated as a movie, showing students how the size and color of our star has evolved and will evolve in time. Animated Orbits of Planets and Moons: The orbital motions of planets, moons, asteroids, and comets are animated at their correct relative speeds in accurate to-scale drawings. Solar System Collisions: This most popular of our applications shows what happens when an asteroid or comet with user-defined size and speed impacts a given planet. The program calculates many effects, including the country of impact (if Earth is the target), energy of explosion, crater size, and magnitude of the ``planetquake'' generated. It also displays a relevant image (e.g. terrestrial crater, lunar crater, etc.). Astronomical Distances: Travel away from the Earth at a chosen speed and see how long it takes to reach other planets, stars and galaxies. This tool helps students visualize astronomical distances in an intuitive way. Funding for the Astronomy Workshop is provided by a NASA EPO grant.

Intranasal Immunization Using Mannatide as a Novel Adjuvant for an Inactivated Influenza Vaccine and Its Adjuvant Effect Compared with MF59.

Directory of Open Access Journals (Sweden)

Shu-Ting Ren

Full Text Available Intranasal vaccination is more potent than parenteral injection for the prevention of influenza. However, because the poor efficiency of antigen uptake across the nasal mucosa is a key issue, immunostimulatory adjuvants are essential for intranasal vaccines. The immunomodulator mannatide or polyactin (PA has been used for the clinical treatment of impaired immunity in China, but its adjuvant effect on an inactivated trivalent influenza vaccine (ITIV via intranasal vaccination is unclear. To explore the adjuvant effect of PA, an inactivated trivalent influenza virus with or without PA or MF59 was instilled intranasally once a week in BALB/c mice. Humoral immunity was assessed by both the ELISA and hemagglutination inhibition (HI methods using antigen-specific antibodies. Splenic lymphocyte proliferation and the IFN-γ level were measured to evaluate cell-mediated immunity. The post-vaccination serum HI antibody geometric mean titers (GMTs for the H1N1 and H3N2 strains, antigen-specific serum IgG and IgA GMTs, mucosal SIgA GMT, splenic lymphocyte proliferation, and IFN-γ were significantly increased in the high-dose PA-adjuvanted vaccine group. The seroconversion rate and the mucosal response for the H3N2 strain were significantly elevated after high-dose PA administration. These adjuvant effects of high-dose PA for the influenza vaccine were comparable with those of the MF59 adjuvant, and abnormal signs or pathological changes were not found in the evaluated organs. In conclusion, PA is a novel mucosal adjuvant for intranasal vaccination with the ITIV that has safe and effective mucosal adjuvanticity in mice and successfully induces both serum and mucosal antibody responses and a cell-mediated response.

Adjuvant solution for pandemic influenza vaccine production.

Science.gov (United States)

Clegg, Christopher H; Roque, Richard; Van Hoeven, Neal; Perrone, Lucy; Baldwin, Susan L; Rininger, Joseph A; Bowen, Richard A; Reed, Steven G

2012-10-23

Extensive preparation is underway to mitigate the next pandemic influenza outbreak. New vaccine technologies intended to supplant egg-based production methods are being developed, with recombinant hemagglutinin (rHA) as the most advanced program for preventing seasonal and avian H5N1 Influenza. Increased efforts are being focused on adjuvants that can broaden vaccine immunogenicity against emerging viruses and maximize vaccine supply on a worldwide scale. Here, we test protection against avian flu by using H5N1-derived rHA and GLA-SE, a two-part adjuvant system containing glucopyranosyl lipid adjuvant (GLA), a formulated synthetic Toll-like receptor 4 agonist, and a stable emulsion (SE) of oil in water, which is similar to the best-in-class adjuvants being developed for pandemic flu. Notably, a single submicrogram dose of rH5 adjuvanted with GLA-SE protects mice and ferrets against a high titer challenge with H5N1 virus. GLA-SE, relative to emulsion alone, accelerated induction of the primary immune response and broadened its durability against heterosubtypic H5N1 virus challenge. Mechanistically, GLA-SE augments protection via induction of a Th1-mediated antibody response. Innate signaling pathways that amplify priming of Th1 CD4 T cells will likely improve vaccine performance against future outbreaks of lethal pandemic flu.

1995 building energy codes and standards workshops: Summary and documentation

Energy Technology Data Exchange (ETDEWEB)

Sandahl, L.J.; Shankle, D.L.

1996-02-01

During the spring of 1995, Pacific Northwest National Laboratory (PNNL) conducted four two-day Regional Building Energy Codes and Standards workshops across the US. Workshops were held in Chicago, Denver, Rhode Island, and Atlanta. The workshops were designed to benefit state-level officials including staff of building code commissions, energy offices, public utility commissions, and others involved with adopting/updating, implementing, and enforcing building energy codes in their states. The workshops provided an opportunity for state and other officials to learn more about residential and commercial building energy codes and standards, the role of the US Department of Energy and the Building Standards and Guidelines Program at Pacific Northwest National Laboratory, Home Energy Rating Systems (HERS), Energy Efficient Mortgages (EEM), training issues, and other topics related to the development, adoption, implementation, and enforcement of building energy codes. Participants heard success stories, got tips on enforcement training, and received technical support materials. In addition to receiving information on the above topics, workshop participants had an opportunity to provide input on code adoption issues, building industry training issues, building design issues, and exemplary programs across the US. This paper documents the workshop planning, findings, and follow-up processes.

Trusted Silicon Stratus (TSS) Workshop

Science.gov (United States)

2011-02-01

business case for a proposed Infrastructure-as-a- Service (IaaS)/ Software -as-a- Service ( SaaS ) cloud architecture. User desires for innovative pricing and...Public Physically Unclonable Function PUF Physically Unclonable Function SaaS Software -as-a- Service SIP Semiconductor Intellectual Property SNL...WORKSHOP NIMBIS SERVICES INCORPORATED FEBRUARY 2011 FINAL TECHNICAL REPORT  ROME, NY 13441 UNITED STATES AIR FORCE  AIR FORCE

The adjuvant potential of synthetic alkylglycerols.

Science.gov (United States)

Acevedo, Reinaldo; Gil, Danay; del Campo, Judith; Bracho, Gustavo; Valdés, Yolanda; Pérez, Oliver

2006-04-12

Alkylglycerols (AGs) have shown immune stimulant and adjuvant activity in many studies, but natural sources are not so accessible and their extraction from them is very complicated. Therefore, a group of chemists at IFAL have synthesized AG analogs. The aim of this work was to evaluate the adjuvant potential of different synthetic AGs. A mix of ovoalbumin (Ova) and AGs increase anti-Ova IgG antibodies production in sera of immunized mice. The predominant subclass was IgG1 although higher levels of IgG2a were observed as the carbon chain length of AGs increased. AGs also induced the production of IL-12 and nitric oxide (NO) in the U937 human histiocyte and J774 mouse macrophage cell lines, respectively. These results indicate that synthetic AGs are effective adjuvants for the standardized antigen, Ova.

An overview of adjuvants utilized in prophylactic vaccine formulation as immunomodulators.

Science.gov (United States)

Chauhan, Nidhi; Tiwari, Sukirti; Iype, Tessy; Jain, Utkarsh

2017-05-01

Development of efficient and cost effective vaccines have been recognized as the primary concern to improve the overall healthcare in a country. In order to achieve this goal, more improved and powerful adjuvants need to be developed. Lacking in the self-adjuvanting immuno-modulatory constituents, vaccines exhibit lower immunogenicity. Combining potent adjuvants with vaccines is the most appropriate method to enhance the efficacy of the vaccines. Hence, this review is focussed on the most potent adjuvants for the formulation of vaccines. Areas covered: This review focuses on Oil-based emulsions, Mineral compounds, Liposomes, Bacterial products, ISCOMs and most recently used nanomaterials as adjuvants for enhancing the antigenicity of vaccines. Furthermore, this review explains the immunological response elicited by various particles. Moreover, case studies are incorporated providing an in depth analyses of various adjuvant-containing vaccines which are currently used. Expert commentary: Enhanced fundamental knowledge about the adjuvants and their immuno-stimulatory capabilities and delivery mechanisms will facilitate the rational designing of prophylactic vaccines with better efficacy.

Environmental adjuvants, apoptosis and the censorship over autoimmunity.

Science.gov (United States)

Rovere-Querini, Patrizia; Manfredi, Angelo A; Sabbadini, Maria Grazia

2005-11-01

Alterations during apoptosis lead to the activation of autoreactive T cells and the production of autoantibodies. This article discusses the pathogenic potential of cells dying in vivo, dissecting the role of signals that favor immune responses (adjuvants) and the influence of genetic backgrounds. Diverse factors determine whether apoptosis leads or not to a self-sustaining, clinically apparent autoimmune disease. The in vivo accumulation of uncleared dying cells per se is not sufficient to cause disease. However, dying cells are antigenic and their complementation with immune adjuvants causes lethal diseases in predisposed lupus-prone animals. At least some adjuvant signals directly target the function and the activation state of antigen presenting cells. Several laboratories are aggressively pursuing the molecular identification of endogenous adjuvants. Sodium monourate and the high mobility group B1 protein (HMGB1) are, among those identified so far, well known to rheumatologists. However, even the complementation of apoptotic cells with potent adjuvant signals fail to cause clinical autoimmunity in most strains: autoantibodies generated are transient, do not undergo to epitope/spreading and do not cause disease. Novel tools for drug development will derive from the molecular identification of the constraints that prevent autoimmunity in normal subjects.

75 FR 20843 - Notice of Workshop To Discuss Policy-Relevant Science to Inform EPA's Integrated Plan for the...

Science.gov (United States)

2010-04-21

... Policy-Relevant Science to Inform EPA's Integrated Plan for the Review of the Lead National Ambient Air.... Environmental Protection Agency (EPA) is announcing that a workshop entitled, ``Workshop to Discuss Policy... workshop will be open to attendance by interested public observers on a first-come, first-served basis up...

Proceedings of the 2010 renewable energy infrastructure workshop

International Nuclear Information System (INIS)

2010-01-01

This workshop provided a forum for electric power industry leaders and key stakeholders to discuss Canada's renewable energy infrastructure needs. The workshop was held to provide practical solutions for meeting the increased demand for renewable energy as well as to offer a range of marketplace options and funding opportunities. Participants in the workshop examined the regulatory framework of the Green Energy Act and its potential impact on organizations. Approval process procedures for renewable energy projects were reviewed, and methods of ensuring the integration of renewable energy projects with current business strategies were discussed. Communications strategies for managing the public perception of energy project were presented. Policy barriers to infrastructure development were outlined. Methods of developing partnerships with Aboriginal communities were also discussed. The conference featured 16 presentations, of which 3 have been catalogued separately for inclusion in this database. tabs., figs.

Adjuvant Therapy for Gallbladder Carcinoma: The Mayo Clinic Experience

International Nuclear Information System (INIS)

Gold, Douglas G.; Miller, Robert C.; Haddock, Michael G.; Gunderson, Leonard L.; Quevedo, Fernando; Donohue, John H.; Bhatia, Sumita; Nagorney, David M.

2009-01-01

Purpose: To analyze the effect of adjuvant chemoradiotherapy on gallbladder carcinoma. Methods and Materials: We retrospectively reviewed the records from consecutive patients who underwent R0 resection of gallbladder carcinoma between January 1, 1985, and December 31, 2004. Patients had either Stage I (T1-T2N0M0) or Stage II (T3N0M0 or T1-T3N1M0) disease. Patients undergoing adjuvant therapy received 5-fluorouracil chemotherapy concurrently with radiotherapy (median dosage, 50.4 Gy in 28 fractions). Adverse prognostic factors and the effect of adjuvant treatment on overall survival (OS) were evaluated. Results: A total of 73 patients were included in the analysis; of these, 25 received adjuvant chemoradiotherapy. On univariate analysis, no adverse prognostic factors for OS reached statistical significance, but trends were noted for Stage N1 vs. N0 (p = .06), Nx vs. N0 (p = .09), Stage T3 vs. T1-T2 (p = .06), and histologic findings other than adenocarcinoma (p = .13). The median OS for patients receiving adjuvant chemoradiotherapy vs. surgery alone was 4.8 years and 4.2 years, respectively (log-rank test, p = .56). However, a significantly greater percentage of patients receiving adjuvant chemoradiotherapy had Stage II disease (p <.001). In the multivariate Cox model, increasing T and N category and histologic findings other than adenocarcinoma were significant predictors of decreased OS. Additionally, adjuvant chemoradiotherapy was a significant predictor of improved OS after adjusting for these prognostic factors (hazard ratio for death, 0.3; 95% confidence interval, 0.13-0.69; p = .004). Conclusion: After adjusting for the stage parameters and histologic findings, our data suggest that adjuvant chemoradiotherapy might improve OS for patients with gallbladder cancer.

Urban Design - Architectural Workshop Nova Gorica

Directory of Open Access Journals (Sweden)

Anja Planišček

2012-01-01

Full Text Available The workshop ran through the 2008-09 academic year. The main themes were a thorough design of Magistrala, the main city street, and research of the spatial and programmatic development alongside it. The research was based on the original urban plan of Nova Gorica designed by architect Edvard Ravnikar in 1949.The workshop was divided into two phases. In the first phase, students researched the possibilities of an overall design for Magistrala (traffic arrangement, relations between built and vacant space, green spaces, public and private domain etc.. In the second phase, they proposed urban architectural interventions in the open spaces along Magistrala (university campus in the northern part of the city, student housing, residential areas, main square, law court, hotel etc..

Surviving and Thriving—Shifting the Public Health Response to HIV-Exposed Uninfected Children: Report of the 3rd HIV-Exposed Uninfected Child Workshop

Directory of Open Access Journals (Sweden)

Amy L. Slogrove

2018-05-01

Full Text Available Great gains were achieved with the introduction of the United Nations' Millennium Development Goals, including improved child survival. Transition to the Sustainable Development Goals (SDGs focused on surviving, thriving, and transforming, representing an important shift to a broader public health goal, the achievement of which holds the promise of longer-term individual and societal benefits. A similar shift is needed with respect to outcomes for infants born to women living with HIV (WLHIV. Programming to prevent vertical HIV transmission has been successful in increasingly achieving a goal of HIV-free survival for infants born to WLHIV. Unfortunately, HIV-exposed uninfected (HEU children are not achieving comparable health and developmental outcomes compared with children born to HIV-uninfected women under similar socioeconomic circumstances. The 3rd HEU Child Workshop, held as a satellite session of the International AIDS Society's 9th IAS Conference in Paris in July 2017, provided a venue to discuss HEU child health and development disparities. A summary of the Workshop proceedings follows, providing current scientific findings, emphasizing the gap in systems for long-term monitoring, and highlighting the public health need to establish a strategic plan to better quantify the short and longer-term health and developmental outcomes of HEU children.

CCME Climate Change Indicators -- Workshop Report

International Nuclear Information System (INIS)

2000-01-01

In an effort to give Canadians a better understanding of the climate change issue, in 1999 the Canadian Council of Ministers of the Environment (CCME) established a Project Working Group to identify and assemble a set of climate change indicators that is scientifically valid, useful and meaningful to the public. To ensure the widest possible participation of experts from all parts of the country the Project Working Group convened a two-day workshop in Toronto to take place on the 6th and 7th of November 2000. The outcome of the workshop, summarized in this report, resulted in a 'Made in Canada' framework of indicators for climate change impacts, divided into five categories: physical environment, personal health and safety, jobs and economic well-being, social and community well-being, and eco-system health. The report contains highlights of the discussions. There are seven appendices containing, respectively, a series of pre-workshop suggestions for indicators (Appendix A), the workshop agenda and backgrounder (Appendix B), a list of participants (Appendix C), presentation slides on the Canada country study (Appendix D), existing and proposed climate change indicators (Appendix E), presentation slides on communication issues (Appendix F), and notes summarizing small group discussions, including assessment of the level of interest demonstrated and opinions expressed by group members about the utility and value of each of the proposed indicators (Appendix G)

Social Networking for Emergency Management and Public Safety

Energy Technology Data Exchange (ETDEWEB)

Lesperance, Ann M.; Olson, Jarrod; Godinez, Melanie A.

2010-08-31

On March 10, 2010 the workshop titled Social Networking for Emergency Management and Public Safety was held in Seattle, WA. The objective of this workshop was to showcase ways social media networking technologies can be used to support emergency management and public safety operations. The workshop highlighted the current state of social networking and where this dynamic engagement is heading, demonstrated some of the more commonly used technologies, highlighted case studies on how these tools have been used in a variety of jurisdictions and engaged the private sector on how these tools might serve as a conduit for two way communication between with the public sector to address regional recovery issues and decision making.

A Performance Enhanced Interactive Learning Workshop Model as a Supplement for Organic Chemistry Instruction

Science.gov (United States)

Phillips, Karen E. S.; Grose-Fifer, Jilliam

2011-01-01

In this study, the authors describe a Performance Enhanced Interactive Learning (PEIL) workshop model as a supplement for organic chemistry instruction. This workshop model differs from many others in that it includes public presentations by students and other whole-class-discussion components that have not been thoroughly investigated in the…

9th Workshop on Stochastic Analysis and Related Topics

CERN Document Server

Decreusefond, Laurent; Stochastic Analysis and Related Topics

2012-01-01

Since the early eighties, Ali Suleyman Ustunel has been one of the main contributors to the field of Malliavin calculus. In a workshop held in Paris, June 2010 several prominent researchers gave exciting talks in honor of his 60th birthday. The present volume includes scientific contributions from this workshop. Probability theory is first and foremost aimed at solving real-life problems containing randomness. Markov processes are one of the key tools for modeling that plays a vital part concerning such problems. Contributions on inventory control, mutation-selection in genetics and public-pri

Report on the Aseismic Slip, Tremor, and Earthquakes Workshop

Science.gov (United States)

Gomberg, Joan; Roeloffs, Evelyn; Trehu, Anne; Dragert, Herb; Meertens, Charles

2008-01-01

This report summarizes the discussions and information presented during the workshop on Aseismic Slip, Tremor, and Earthquakes. Workshop goals included improving coordination among those involved in conducting research related to these phenomena, assessing the implications for earthquake hazard assessment, and identifying ways to capitalize on the education and outreach opportunities presented by these phenomena. Research activities of focus included making, disseminating, and analyzing relevant measurements; the relationships among tremor, aseismic or 'slow-slip', and earthquakes; and discovering the underlying causative physical processes. More than 52 participants contributed to the workshop, held February 25-28, 2008 in Sidney, British Columbia. The workshop was sponsored by the U.S. Geological Survey, the National Science Foundation?s Earthscope Program and UNAVCO Consortium, and the Geological Survey of Canada. This report has five parts. In the first part, we integrate the information exchanged at the workshop as it relates to advancing our understanding of earthquake generation and hazard. In the second part, we summarize the ideas and concerns discussed in workshop working groups on Opportunities for Education and Outreach, Data and Instrumentation, User and Public Needs, and Research Coordination. The third part presents summaries of the oral presentations. The oral presentations are grouped as they were at the workshop in the categories of phenomenology, underlying physical processes, and implications for earthquake hazards. The fourth part contains the meeting program and the fifth part lists the workshop participants. References noted in parentheses refer to the authors of presentations made at the workshop, and published references are noted in square brackets and listed in the Reference section. Appendix A contains abstracts of all participant presentations and posters, which also have been posted online, along with presentations and author contact

Eighteenth workshop on geothermal reservoir engineering: Proceedings

Energy Technology Data Exchange (ETDEWEB)

Ramey, H.J. Jr.; Horne, R.J.; Kruger, P.; Miller, F.G.; Brigham, W.E.; Cook, J.W. (Stanford Geothermal Program)

1993-01-28

PREFACE The Eighteenth Workshop on Geothermal Reservoir Engineering was held at Stanford University on January 26-28, 1993. There were one hundred and seventeen registered participants which was greater than the attendance last year. Participants were from eight foreign countries: Italy, Japan, United Kingdom, Mexico, New Zealand, the Philippines, Guatemala, and Iceland. Performance of many geothermal fields outside the United States was described in several of the papers. Dean Gary Ernst opened the meeting and welcomed the visitors to the campus. The key note speaker was J.E. ''Ted'' Mock who gave a brief overview of the Department of Energy's current plan. The Stanford Geothermal Program Reservoir Engineering Award for Excellence in Development of Geothermal Energy was awarded to Dr. Mock who also spoke at the banquet. Thirty-nine papers were presented at the Workshop with two papers submitted for publication only. Technical papers were organized in twelve sessions concerning: field operations, The Geysers, geoscience, hot-dry-rock, injection, modeling, slim hole wells, geochemistry, well test and wellbore. Session chairmen were major contributors to the program and we thank: John Counsil, Kathleen Enedy, Harry Olson, Eduardo Iglesias, Marcelo Lippmann, Paul Atkinson, Jim Lovekin, Marshall Reed, Antonio Correa, and David Faulder. The Workshop was organized by the Stanford Geothermal Program faculty, staff, and graduate students. We wish to thank Pat Ota, Ted Sumida, and Terri A. Ramey who also produces the Proceedings Volumes for publication. We owe a great deal of thanks to our students who operate audiovisual equipment and to John Hornbrook who coordinated the meeting arrangements for the Workshop. Henry J. Ramey, Jr. Roland N. Horne Frank G. Miller Paul Kruger William E. Brigham Jean W. Cook

ADJUVANT PHARMACOTERAPEUTICAL PROFILE OF ONCOLOGICAL PATIENTS FROM A WELCOMING HOUSE INSIDE THE BAHIA

Directory of Open Access Journals (Sweden)

Phydel Palmeira Carvalho

2017-05-01

Full Text Available Cancer is one of the most important public health problems worldwide and is among the main causes of death. The purpose of this study is to outline the adjuvant pharmacotherapeutic profile in the palliative support of cancer patients in a nursing home in the city of Vitória da Conquista - Bahia. Twenty-seven individuals over 40 years of age were interviewed, the variables studied were socioeconomic, comorbidities and palliative medication prescriptions. The research was performed during the months of October to December 2014. The most frequent signs and symptoms were weakness (96%, pain (70%, constipation (67% and insomnia (67%. The main adjuvant treatments were treatment of cancer pain (30.7% and inhibition of emesis (28.4%. It is concluded that palliative pharmacotherapeutic support was used in the treatment of cancer patients, with prevalence of drugs for pain, nausea and emesis control, as well as prophylaxis of ulcerations.

Droplet evaporation and spread on waxy and hairy leaves associated with type and concentration of adjuvants.

Science.gov (United States)

Xu, Linyun; Zhu, Heping; Ozkan, H Erdal; Bagley, William E; Krause, Charles R

2011-07-01

Adjuvants can improve pesticide application efficiency and effectiveness. However, quantifications of the adjuvant-amended pesticide droplet actions on foliage, which could affect application efficiencies, are largely unknown. Droplet evaporation rates and spread on waxy or hairy leaves varied greatly with the adjuvant types tested. On waxy leaves, the wetted areas of droplets containing crop oil concentrate (COC) were significantly smaller than those containing modified seed oil (MSO), non-ionic surfactant (NIS) or oil surfactant blend (OSB), whereas the evaporation rates of COC-amended droplets were significantly higher. On hairy leaves, COC-amended droplets remained on top of the hairs without wetting the epidermis. When the relative concentration was 1.50, the wetted area of droplets with NIS was 9.2 times lower than that with MSO and 6.1 times lower than that with OSB. The wetted area increased as the adjuvant concentration increased. MSO- or OSB-amended droplets spread extensively on the hairy leaf surface until they were completely dried. These results demonstrated that the proper concentration of MSO, NIS or OSB in spray mixtures improved the homogeneity of spray coverage on both waxy and hairy leaf surfaces and could reduce pesticide use. This article is a US Government work and is in the public domain in the USA. Published 2011 by John Wiley & Sons, Ltd.

Implementation and Outcomes of a Faculty-Based, Peer Review Manuscript Writing Workshop.

Science.gov (United States)

Kulage, Kristine M; Larson, Elaine L

2016-01-01

The publication of scholarly work and research findings is an important expectation for nursing faculty; however, academic writing is often neglected, leaving dissemination through manuscript writing an area of concern for the nursing profession. Writing initiatives have been utilized to promote scholarly dissemination in schools of nursing, but those described in the literature have been primarily non-United States based and student focused. This article describes a faculty-based manuscript writing workshop, assesses participants' impressions, and describes its impact on scholarly output. The workshop is a collaborative learning process utilizing peer review to improve manuscript quality and model behaviors for improving writing and peer-reviewing skills. Seventeen workshop participants including three predoctoral students, 6 postdoctoral fellows, and 8 faculty members completed an anonymous workshop survey (81% response rate). All but 1 of 17 manuscripts reviewed in the workshop are published, accepted, or in the review process. All participants indicated that the workshop was a valuable use of time and would recommend it to colleagues. The greatest reported workshop benefit was its function as an impetus to complete and submit manuscripts. We recommend the manuscript writing workshop model for other schools of nursing seeking ways to expand their scholarly output and create accountability for dissemination through manuscript writing. Copyright © 2016 Elsevier Inc. All rights reserved.

GLA-AF, an emulsion-free vaccine adjuvant for pandemic influenza.

Science.gov (United States)

Clegg, Christopher H; Roque, Richard; Perrone, Lucy A; Rininger, Joseph A; Bowen, Richard; Reed, Steven G

2014-01-01

The ongoing threat from Influenza necessitates the development of new vaccine and adjuvant technologies that can maximize vaccine immunogenicity, shorten production cycles, and increase global vaccine supply. Currently, the most successful adjuvants for Influenza vaccines are squalene-based oil-in-water emulsions. These adjuvants enhance seroprotective antibody titers to homologous and heterologous strains of virus, and augment a significant dose sparing activity that could improve vaccine manufacturing capacity. As an alternative to an emulsion, we tested a simple lipid-based aqueous formulation containing a synthetic TLR4 ligand (GLA-AF) for its ability to enhance protection against H5N1 infection. GLA-AF was very effective in adjuvanting recombinant H5 hemagglutinin antigen (rH5) in mice and was as potent as the stable emulsion, SE. Both adjuvants induced similar antibody titers using a sub-microgram dose of rH5, and both conferred complete protection against a highly pathogenic H5N1 challenge. However, GLA-AF was the superior adjuvant in ferrets. GLA-AF stimulated a broader antibody response than SE after both the prime and boost immunization with rH5, and ferrets were better protected against homologous and heterologous strains of H5N1 virus. Thus, GLA-AF is a potent emulsion-free adjuvant that warrants consideration for pandemic influenza vaccine development.

Long-term heart function after adjuvant epirubicin chemotherapy for breast cancer

DEFF Research Database (Denmark)

Appel, Jon M; Zerahn, Bo; Møller, Susanne

2012-01-01

Newer studies raise concern that adjuvant anthracycline treatment for breast cancer (BC) causes long-term heart damage. We aimed to examine whether heart failure or impairment could be demonstrated several years after low-dose epirubicin-based adjuvant treatment.......Newer studies raise concern that adjuvant anthracycline treatment for breast cancer (BC) causes long-term heart damage. We aimed to examine whether heart failure or impairment could be demonstrated several years after low-dose epirubicin-based adjuvant treatment....

Adjuvant Biological Therapies in Chronic Leg Ulcers

Directory of Open Access Journals (Sweden)

Natalia Burgos-Alonso

2017-11-01

Full Text Available Current biological treatments for non-healing wounds aim to address the common deviations in healing mechanisms, mainly inflammation, inadequate angiogenesis and reduced synthesis of extracellular matrix. In this context, regenerative medicine strategies, i.e., platelet rich plasmas and mesenchymal stromal cell products, may form part of adjuvant interventions in an integral patient management. We synthesized the clinical experience on ulcer management using these two categories of biological adjuvants. The results of ten controlled trials that are included in this systematic review favor the use of mesenchymal stromal cell based-adjuvants for impaired wound healing, but the number and quality of studies is moderate-low and are complicated by the diversity of biological products. Regarding platelet-derived products, 18 controlled studies investigated their efficacy in chronic wounds in the lower limb, but the heterogeneity of products and protocols hinders clinically meaningful quantitative synthesis. Most patients were diabetic, emphasizing an unmet medical need in this condition. Overall, there is not sufficient evidence to inform routine care, and further clinical research is necessary to realize the full potential of adjuvant regenerative medicine strategies in the management of chronic leg ulcers.

Effectiveness of a 1-day workshop on scientific writing conducted by the Indian journal of rheumatology

Directory of Open Access Journals (Sweden)

Mohit Goyal

2018-01-01

Full Text Available Background: Writing a scientific manuscript is an important skill to acquire for junior doctors considering the mandatory requirement of research publications during post-graduate training and for career advancement in India. Methods: We conducted a one-day workshop on scientific writing and publication at Udaipur in November 2017, comprising both didactic lectures as well as hands-on evaluation of a dummy manuscript, and evaluated structured questionnaires filled pre- and post-workshop. Results: There were 120 attendees, most of whom were junior doctors with little or no prior experience in writing a scientific paper. A significant baseline knowledge deficit regarding the principles and processes of scientific writing (ranging from 20.9% to 77.3% participants for the different questions asked could be identified before the workshop. This knowledge deficit was significantly improved in most areas as assessed after the workshop. We identified the need to discuss predatory publishing in greater detail in subsequent workshops, as 20.8% of respondents after the workshop professed that they might consider publishing in a predatory journal. As expressed in participant feedback, longer, more-specialized or advanced level workshops on scientific writing in the future could also consider including more details on appropriate statistical presentation and pictorial representation of data as well as longer time spent on hands-on exercises. Conclusion: There remains a need to conduct more scientific writing workshops by national societies and journals all over the country.

76 FR 31350 - Public Workshop; Privacy Compliance Basics and 2011 Developments

Science.gov (United States)

2011-05-31

... Privacy Act of 1974, as amended, the E-Government Act of 2002, Office of Management and Budget memoranda... telephone 703-235-0780; by facsimile 703-235-0442; or by e-mail at [email protected] . SUPPLEMENTARY INFORMATION... send an e-mail to [email protected] , with ``PRIVComplianceWorkshop'' in the subject line, and your full name...

Adjuvant therapy for ampullary carcinomas: The Mayo Clinic experience

International Nuclear Information System (INIS)

Bhatia, Sumita; Miller, Robert C.; Haddock, Michael G.; Donohue, John H.; Krishnan, Sunil

2006-01-01

Purpose: To determine the effects of adjuvant radiotherapy and chemotherapy for carcinoma of the ampulla of Vater. Methods and Materials: We retrospectively reviewed the records of 125 patients who underwent definitive surgery for carcinomas involving the ampulla of Vater between April 1977 and February 2005 and who survived more than 50 days after surgery. Twenty-nine of the patients also received adjuvant radiotherapy (median dose, 50.4 Gy in 28 fractions) with concurrent 5-fluorouracil chemotherapy. Adverse prognostic factors were investigated, and overall survival (OS) and local and distant failure were estimated. Results: Adverse prognostic factors for decreased OS by univariate analysis included lymph node (LN) involvement, locally advanced tumors (T3/T4), and poor histologic grade. By multivariate analysis, positive LN status (p = 0.02) alone was associated with decreased OS. The addition of adjuvant radiotherapy and chemotherapy improved OS for patients with positive LN (p = 0.01). Median survival for positive LN patients receiving adjuvant therapy was 3.4 years, vs. 1.6 years for those with surgery alone. Conclusions: The addition of adjuvant radiotherapy and 5-fluorouracil chemotherapy may improve OS in patients with LN involvement. The effect of adjuvant therapy on outcomes for patients with poor histologic grade or T3/T4 tumors without LN involvement could not be assessed

Antigen sparing with adjuvanted inactivated polio vaccine based on Sabin strains.

Science.gov (United States)

Westdijk, Janny; Koedam, Patrick; Barro, Mario; Steil, Benjamin P; Collin, Nicolas; Vedvick, Thomas S; Bakker, Wilfried A M; van der Ley, Peter; Kersten, Gideon

2013-02-18

Six different adjuvants, each in combination with inactivated polio vaccine (IPV) produced with attenuated Sabin strains (sIPV), were evaluated for their ability to enhance virus neutralizing antibody titres (VNTs) in the rat potency model. The increase of VNTs was on average 3-, 15-, 24-fold with adjuvants after one immunization (serotypes 1, 2, and 3, respectively). Also after a boost immunization the VNTs of adjuvanted sIPV were on average another 7-20-27 times higher than after two inoculations of sIPV without adjuvant. The results indicate that it is feasible to increase the potency of inactivated polio vaccines by using adjuvants. Copyright © 2013 Elsevier Ltd. All rights reserved.

Laser vaccine adjuvants. History, progress, and potential.

Science.gov (United States)

Kashiwagi, Satoshi; Brauns, Timothy; Gelfand, Jeffrey; Poznansky, Mark C

2014-01-01

Immunologic adjuvants are essential for current vaccines to maximize their efficacy. Unfortunately, few have been found to be sufficiently effective and safe for regulatory authorities to permit their use in vaccines for humans and none have been approved for use with intradermal vaccines. The development of new adjuvants with the potential to be both efficacious and safe constitutes a significant need in modern vaccine practice. The use of non-damaging laser light represents a markedly different approach to enhancing immune responses to a vaccine antigen, particularly with intradermal vaccination. This approach, which was initially explored in Russia and further developed in the US, appears to significantly improve responses to both prophylactic and therapeutic vaccines administered to the laser-exposed tissue, particularly the skin. Although different types of lasers have been used for this purpose and the precise molecular mechanism(s) of action remain unknown, several approaches appear to modulate dendritic cell trafficking and/or activation at the irradiation site via the release of specific signaling molecules from epithelial cells. The most recent study, performed by the authors of this review, utilized a continuous wave near-infrared laser that may open the path for the development of a safe, effective, low-cost, simple-to-use laser vaccine adjuvant that could be used in lieu of conventional adjuvants, particularly with intradermal vaccines. In this review, we summarize the initial Russian studies that have given rise to this approach and comment upon recent advances in the use of non-tissue damaging lasers as novel physical adjuvants for vaccines.

Chemokines as Cancer Vaccine Adjuvants

Directory of Open Access Journals (Sweden)

Agne Petrosiute

2013-10-01

Full Text Available We are witnessing a new era of immune-mediated cancer therapies and vaccine development. As the field of cancer vaccines advances into clinical trials, overcoming low immunogenicity is a limiting step in achieving full success of this therapeutic approach. Recent discoveries in the many biological roles of chemokines in tumor immunology allow their exploitation in enhancing recruitment of antigen presenting cells (APCs and effector cells to appropriate anatomical sites. This knowledge, combined with advances in gene therapy and virology, allows researchers to employ chemokines as potential vaccine adjuvants. This review will focus on recent murine and human studies that use chemokines as therapeutic anti-cancer vaccine adjuvants.

Developing workshop module of realistic mathematics education: Follow-up workshop

Science.gov (United States)

Palupi, E. L. W.; Khabibah, S.

2018-01-01

Realistic Mathematics Education (RME) is a learning approach which fits the aim of the curriculum. The success of RME in teaching mathematics concepts, triggering students’ interest in mathematics and teaching high order thinking skills to the students will make teachers start to learn RME. Hence, RME workshop is often offered and done. This study applied development model proposed by Plomp. Based on the study by RME team, there are three kinds of RME workshop: start-up workshop, follow-up workshop, and quality boost. However, there is no standardized or validated module which is used in that workshops. This study aims to develop a module of RME follow-up workshop which is valid and can be used. Plopm’s developmental model includes materials analysis, design, realization, implementation, and evaluation. Based on the validation, the developed module is valid. While field test shows that the module can be used effectively.

AS03-adjuvanted versus non-adjuvanted inactivated trivalent influenza vaccine against seasonal influenza in elderly people: a phase 3 randomised trial

NARCIS (Netherlands)

McElhaney, J.E.; Beran, J.; Devaster, J.M.; Esen, M.; Launay, O.; Leroux-Roels, G.; Ruiz-Palacios, G.M.; Essen, G.A. van; Caplanusi, A.; Claeys, C.; Durand, C.; Duval, X.; Idrissi, M. El; Falsey, A.R.; Feldman, G.; Frey, S.E.; Galtier, F.; Hwang, S.J.; Innis, B.L.; Kovac, M.; Kremsner, P.; McNeil, S.; Nowakowski, A.; Richardus, J.H.; Trofa, A.; Oostvogels, L.; Verheugt, F.W.; et al.,

2013-01-01

BACKGROUND: We aimed to compare AS03-adjuvanted inactivated trivalent influenza vaccine (TIV) with non-adjuvanted TIV for seasonal influenza prevention in elderly people. METHODS: We did a randomised trial in 15 countries worldwide during the 2008-09 (year 1) and 2009-10 (year 2) influenza seasons.

Creating Fantastic PI Workshops

Energy Technology Data Exchange (ETDEWEB)

Biedermann, Laura B. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Clark, Blythe G. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Colbert, Rachel S. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Dagel, Amber Lynn [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Gupta, Vipin P. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Hibbs, Michael R. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Perkins, David Nikolaus [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); West, Roger Derek [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

2015-10-01

The goal of this SAND report is to provide guidance for other groups hosting workshops and peerto-peer learning events at Sandia. Thus this SAND report provides detail about our team structure, how we brainstormed workshop topics and developed the workshop structure. A Workshop “Nuts and Bolts” section provides our timeline and check-list for workshop activities. The survey section provides examples of the questions we asked and how we adapted the workshop in response to the feedback.

Hypothesis driven development of new adjuvants: short peptides as immunomodulators.

Science.gov (United States)

Dong, Jessica C; Kobinger, Gary P

2013-04-01

To date, vaccinations have been one of the key strategies in the prevention and protection against infectious pathogens. Traditional vaccines have well-known limitations such as safety and efficacy issues, which consequently deems it inappropriate for particular populations and may not be an effective strategy against all pathogens. This evidence highlights the need to develop more efficacious vaccination regiments. Higher levels of protection can be achieved by the addition of immunostimulating adjuvants. Many adjuvants elicit strong, undefined inflammation, which produces increased immunogenicity but may also lead to undesirable effects. Hypothesis driven development of adjuvants is needed to achieve a more specific and directed immune response required for optimal and safe vaccine-induced immune protection. An example of such hypothesis driven development includes the use of short immunomodulating peptides as adjuvants. These peptides have the ability to influence the immune response and can be extrapolated for adjuvant use, but requires further investigation.

Development of a minimal saponin vaccine adjuvant based on QS-21

Science.gov (United States)

Fernández-Tejada, Alberto; Chea, Eric K.; George, Constantine; Pillarsetty, Nagavarakishore; Gardner, Jeffrey R.; Livingston, Philip O.; Ragupathi, Govind; Lewis, Jason S.; Tan, Derek S.; Gin, David Y.

2014-07-01

Adjuvants are materials added to vaccines to enhance the immunological response to an antigen. QS-21 is a natural product adjuvant under investigation in numerous vaccine clinical trials, but its use is constrained by scarcity, toxicity, instability and an enigmatic molecular mechanism of action. Herein we describe the development of a minimal QS-21 analogue that decouples adjuvant activity from toxicity and provides a powerful platform for mechanistic investigations. We found that the entire branched trisaccharide domain of QS-21 is dispensable for adjuvant activity and that the C4-aldehyde substituent, previously proposed to bind covalently to an unknown cellular target, is also not required. Biodistribution studies revealed that active adjuvants were retained preferentially at the injection site and the nearest draining lymph nodes compared with the attenuated variants. Overall, these studies have yielded critical insights into saponin structure-function relationships, provided practical synthetic access to non-toxic adjuvants, and established a platform for detailed mechanistic studies.

Between the Stars: A Professional Development Workshop for Teachers

Science.gov (United States)

Hemenway, Mary Kay; Redfield, S.

2008-05-01

A workshop for secondary school science teachers was conducted at McDonald Observatory in July 2007. Participants did classroom experiments to detect and compare radiation in the ultraviolet, optical, and infrared regions of the electromagnetic spectrum. Other activities involved various aspects of stellar evolution and telescope design. They built spectrometers and considered how astronomers use scientific models. These topics were chosen to help them form a conceptual understanding of the parent projects' research topic: Variations in the Ionization Structure within the Local Interstellar Cloud and Neighboring Clouds. Fifteen teachers from Alaska, Idaho, Michigan, New York, Ohio, Oklahoma, and Texas performed these standards-aligned activities at the workshop in preparation for using them within their own classrooms. During three scheduled nights of observing, the participants became familiar with the night sky and the operation of small telescopes. The workshop included tours of other observatory facilities and time to reflect on their own teaching practices. They concluded the workshop by developing concept maps that integrated all aspects of the workshop, including lectures, activities, observing experiences, and tours. Support from The National Aeronautics and Space Administration under an Education and Public Outreach supplement to the Far Ultraviolet Spectroscopic Explorer Guest Investigator grant NNX07AN07G issued through the Office of Space Science is gratefully acknowledged.

Advax, a Delta Inulin Microparticle, Potentiates In-built Adjuvant Property of Co-administered Vaccines

Directory of Open Access Journals (Sweden)

Masayuki Hayashi

2017-02-01

Full Text Available Advax, a delta inulin-derived microparticle, has been developed as an adjuvant for several vaccines. However, its immunological characteristics and potential mechanism of action are yet to be elucidated. Here, we show that Advax behaves as a type-2 adjuvant when combined with influenza split vaccine, a T helper (Th2-type antigen, but behaves as a type-1 adjuvant when combined with influenza inactivated whole virion (WV, a Th1-type antigen. In addition, an adjuvant effect was not observed when Advax-adjuvanted WV vaccine was used to immunize toll-like receptor (TLR 7 knockout mice which are unable to respond to RNA contained in WV antigen. Similarly, no adjuvant effect was seen when Advax was combined with endotoxin-free ovalbumin, a neutral Th0-type antigen. An adjuvant effect was also not seen in tumor necrosis factor (TNF-α knockout mice, and the adjuvant effect required the presences of dendritic cells (DCs and phagocytic macrophages. Therefore, unlike other adjuvants, Advax potentiates the intrinsic or in-built adjuvant property of co-administered antigens. Hence, Advax is a unique class of adjuvant which can potentiate the intrinsic adjuvant feature of the vaccine antigens through a yet to be determined mechanism.

Sixteenth workshop on geothermal reservoir engineering: Proceedings

Energy Technology Data Exchange (ETDEWEB)

Ramey, H.J. Jr.; Kruger, P.; Miller, F.G.; Horne, R.N.; Brigham, W.E.; Cook, J.W. (Stanford Geothermal Program)

1991-01-25

The Sixteenth Workshop on Geothermal Reservoir Engineering was held at Stanford University on January 23-25, 1991. The Workshop Banquet Speaker was Dr. Mohinder Gulati of UNOCAL Geothermal. Dr. Gulati gave an inspiring talk on the impact of numerical simulation on development of geothermal energy both in The Geysers and the Philippines. Dr. Gulati was the first recipient of The Stanford Geothermal Program Reservoir Engineering Award for Excellence in Development of Geothermal Energy. Dr. Frank Miller presented the award. The registered attendance figure of one hundred fifteen participants was up slightly from last year. There were seven foreign countries represented: Iceland, Italy, Philippines, Kenya, the United Kingdom, Mexico, and Japan. As last year, papers on about a dozen geothermal fields outside the United States were presented. There were thirty-six papers presented at the Workshop, and two papers were submitted for publication only. Attendees were welcomed by Dr. Khalid Aziz, Chairman of the Petroleum Engineering Department at Stanford. Opening remarks were presented by Dr. Roland Horne, followed by a discussion of the California Energy Commission's Geothermal Activities by Barbara Crowley, Vice Chairman; and J.E. ''Ted'' Mock's presentation of the DOE Geothermal Program: New Emphasis on Industrial Participation. Technical papers were organized in twelve sessions concerning: hot dry rock, geochemistry, tracer injection, field performance, modeling, and chemistry/gas. As in previous workshops, session chairpersons made major contributions to the program. Special thanks are due to Joel Renner, Jeff Tester, Jim Combs, Kathy Enedy, Elwood Baldwin, Sabodh Garg, Marcel0 Lippman, John Counsil, and Eduardo Iglesias. The Workshop was organized by the Stanford Geothermal Program faculty, staff, and graduate students. We wish to thank Pat Ota, Angharad Jones, Rosalee Benelli, Jeanne Mankinen, Ted Sumida, and Terri A. Ramey who also

Who Benefits From Adjuvant Radiation Therapy for Gastric Cancer? A Meta-Analysis

International Nuclear Information System (INIS)

Ohri, Nitin; Garg, Madhur K.; Aparo, Santiago; Kaubisch, Andreas; Tome, Wolfgang; Kennedy, Timothy J.; Kalnicki, Shalom; Guha, Chandan

2013-01-01

Purpose: Large randomized trials have demonstrated significant survival benefits with the use of adjuvant chemotherapy or chemoradiation therapy for gastric cancer. The importance of adjuvant radiation therapy (RT) remains unclear. We performed an up-to-date meta-analysis of randomized trials testing the use of RT for resectable gastric cancer. Methods and Materials: We searched MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials for randomized trials testing adjuvant (including neoadjuvant) RT for resectable gastric cancer. Hazard ratios describing the impact of adjuvant RT on overall survival (OS) and disease-free survival (DFS) were extracted directly from the original studies or calculated from survival curves. Pooled estimates were obtained using the inverse variance method. Subgroup analyses were performed to determine whether the efficacy of RT varies with chemotherapy use, RT timing, geographic region, type of nodal dissection performed, or lymph node status. Results: Thirteen studies met all inclusion criteria and were used for this analysis. Adjuvant RT was associated with a significant improvement in both OS (HR = 0.78, 95% CI: 0.70-0.86, P<.001) and DFS (HR = 0.71, 95% CI: 0.63-0.80, P<.001). In the 5 studies that tested adjuvant chemoradiation therapy against adjuvant chemotherapy, similar effects were seen for OS (HR = 0.83, 95% CI: 0.67-1.03, P=.087) and DFS (HR = 0.77, 95% CI: 0.91-0.65, P=.002). Available data did not reveal any subgroup of patients that does not benefit from adjuvant RT. Conclusion: In randomized trials for resectable gastric cancer, adjuvant RT provides an approximately 20% improvement in both DFS and OS. Available data do not reveal a subgroup of patients that does not benefit from adjuvant RT. Further study is required to optimize the implementation of adjuvant RT for gastric cancer with regard to patient selection and integration with systemic therapy

Adjuvant Chemoradiation Therapy for Pancreatic Adenocarcinoma: Who Really Benefits?

Science.gov (United States)

Merchant, Nipun B; Rymer, Jennifer; Koehler, Elizabeth AS; Ayers, G Daniel; Castellanos, Jason; Kooby, David A; Weber, Sharon H; Cho, Clifford S; Schmidt, C Max; Nakeeb, Atilla; Matos, Jesus M; Scoggins, Charles R; Martin, Robert CG; Kim, Hong Jin; Ahmad, Syed A; Chu, Carrie K; McClaine, Rebecca; Bednarski, Brian K; Staley, Charles A; Sharp, Kenneth; Parikh, Alexander A

2014-01-01

BACKGROUND The role of adjuvant chemoradiation therapy (CRT) in pancreatic cancer remains controversial. The primary aim of this study was to determine if CRT improved survival in patients with resected pancreatic cancer in a large, multiinstitutional cohort of patients. STUDY DESIGN Patients undergoing resection for pancreatic adenocarcinoma from seven academic medical institutions were included. Exclusion criteria included patients with T4 or M1 disease, R2 resection margin, preoperative therapy, chemotherapy alone, or if adjuvant therapy status was unknown. RESULTS There were 747 patients included in the initial evaluation. Primary analysis was performed between patients that had surgery alone (n = 374) and those receiving adjuvant CRT (n = 299). Median followup time was 12.2 months and 14.5 months for survivors. Median overall survival for patients receiving adjuvant CRT was significantly longer than for those undergoing operation alone (20.0 months versus 14.5 months, p = 0.001). On subset and multivariate analysis, adjuvant CRT demonstrated a significant survival advantage only among patients who had lymph node (LN)-positive disease (hazard ratio 0.477, 95% CI 0.357 to 0.638) and not for LN-negative patients (hazard ratio 0.810, 95% CI 0.556 to 1.181). Disease-free survival in patients with LN-negative disease who received adjuvant CRT was significantly worse than in patients who had surgery alone (14.5 months versus 18.6 months, p = 0.034). CONCLUSIONS This large multiinstitutional study emphasizes the importance of analyzing subsets of patients with pancreas adenocarcinoma who have LN metastasis. Benefit of adjuvant CRT is seen only in patients with LN-positive disease, regardless of resection margin status. CRT in patients with LN-negative disease may contribute to reduced disease-free survival. PMID:19476845

1996 DOE technical standards program workshop: Proceedings

Energy Technology Data Exchange (ETDEWEB)

NONE

1996-07-01

The workshop theme is `The Strategic Standardization Initiative - A Technology Exchange and Global Competitiveness Challenge for DOE.` The workshop goal is to inform the DOE technical standards community of strategic standardization activities taking place in the Department, other Government agencies, standards developing organizations, and industry. Individuals working on technical standards will be challenged to improve cooperation and communications with the involved organizations in response to the initiative. Workshop sessions include presentations by representatives from various Government agencies that focus on coordination among and participation of Government personnel in the voluntary standards process; reports by standards organizations, industry, and DOE representatives on current technology exchange programs; and how the road ahead appears for `information superhighway` standardization. Another session highlights successful standardization case studies selected from several sites across the DOE complex. The workshop concludes with a panel discussion on the goals and objectives of the DOE Technical Standards Program as envisioned by senior DOE management. The annual workshop on technical standards has proven to be an effective medium for communicating information related to standards throughout the DOE community. Technical standards are used to transfer technology and standardize work processes to produce consistent, acceptable results. They provide a practical solution to the Department`s challenge to protect the environment and the health and safety of the public and workers during all facility operations. Through standards, the technologies of industries and governments worldwide are available to DOE. The DOE Technical Standards Program, a Department-wide effort that crosscuts all organizations and disciplines, links the Department to those technologies.

Immune adjuvant activity of the olive, soybean and corn oils

Directory of Open Access Journals (Sweden)

Ana Claudia Marinho da Silva

2016-08-01

Full Text Available In the last half of the century, a large amount of substances has been used as immune adjuvant. The immune adjuvant effect of olive, soybean and corn oils in Swiss mice immunized with ovalbumin (OVA plus aluminum hydroxide or emulsified in Marcol, soybean, olive or corn oils was evaluated through the OVA-specific antibodies determined by ELISA and Passive Cutaneous Anaphylaxis. In this work the comparison of the intensity of the immune response was established by the Bayesian analysis. The adjuvant effect of the vegetable oils was shown to be more effective than aluminium hydroxide. Regarding to OVA-specific IgE synthesis, olive oil had the slowest adjuvant effect of the three vegetable oils. Accordingly, olive oil was the most convenient among the vegetable oils to be used as immune adjuvant, since it stimulated a higher production of OVA-specific Ig and lower levels of anti-OVA IgE.

Learning impairment in honey bees caused by agricultural spray adjuvants.

Directory of Open Access Journals (Sweden)

Timothy J Ciarlo

Full Text Available BACKGROUND: Spray adjuvants are often applied to crops in conjunction with agricultural pesticides in order to boost the efficacy of the active ingredient(s. The adjuvants themselves are largely assumed to be biologically inert and are therefore subject to minimal scrutiny and toxicological testing by regulatory agencies. Honey bees are exposed to a wide array of pesticides as they conduct normal foraging operations, meaning that they are likely exposed to spray adjuvants as well. It was previously unknown whether these agrochemicals have any deleterious effects on honey bee behavior. METHODOLOGY/PRINCIPAL FINDINGS: An improved, automated version of the proboscis extension reflex (PER assay with a high degree of trial-to-trial reproducibility was used to measure the olfactory learning ability of honey bees treated orally with sublethal doses of the most widely used spray adjuvants on almonds in the Central Valley of California. Three different adjuvant classes (nonionic surfactants, crop oil concentrates, and organosilicone surfactants were investigated in this study. Learning was impaired after ingestion of 20 µg organosilicone surfactant, indicating harmful effects on honey bees caused by agrochemicals previously believed to be innocuous. Organosilicones were more active than the nonionic adjuvants, while the crop oil concentrates were inactive. Ingestion was required for the tested adjuvant to have an effect on learning, as exposure via antennal contact only induced no level of impairment. CONCLUSIONS/SIGNIFICANCE: A decrease in percent conditioned response after ingestion of organosilicone surfactants has been demonstrated here for the first time. Olfactory learning is important for foraging honey bees because it allows them to exploit the most productive floral resources in an area at any given time. Impairment of this learning ability may have serious implications for foraging efficiency at the colony level, as well as potentially many

Adjuvant and Definitive Radiotherapy for Adrenocortical Carcinoma

International Nuclear Information System (INIS)

Sabolch, Aaron; Feng, Mary; Griffith, Kent; Hammer, Gary; Doherty, Gerard; Ben-Josef, Edgar

2011-01-01

Purpose: To evaluate the impact of both adjuvant and definitive radiotherapy on local control of adrenocortical carcinoma. Methods and Materials: Outcomes were analyzed from 58 patients with 64 instances of treatment for adrenocortical carcinoma at the University of Michigan's Multidisciplinary Adrenal Cancer Clinic. Thirty-seven of these instances were for primary disease, whereas the remaining 27 were for recurrent disease. Thirty-eight of the treatment regimens involved surgery alone, 10 surgery plus adjuvant radiotherapy, and 16 definitive radiotherapy for unresectable disease. The effects of patient, tumor, and treatment factors were modeled simultaneously using multiple variable Cox proportional hazards regression for associations with local recurrence, distant recurrence, and overall survival. Results: Local failure occurred in 16 of the 38 instances that involved surgery alone, in 2 of the 10 that consisted of surgery plus adjuvant radiotherapy, and in 1 instance of definitive radiotherapy. Lack of radiotherapy use was associated with 4.7 times the risk of local failure compared with treatment regimens that involved radiotherapy (95% confidence interval, 1.2-19.0; p = 0.030). Conclusions: Radiotherapy seems to significantly lower the risk of local recurrence/progression in patients with adrenocortical carcinoma. Adjuvant radiotherapy should be strongly considered after surgical resection.

Rethinking Information Systems in the Public Sector

DEFF Research Database (Denmark)

Medaglia, Rony

2014-01-01

This section of Information Polity consists of papers presented during the workshop “Rethinking Information Systems in the Public Sector: Bridging Academia and Public Service”. The workshop was held on 8 June 2014 in Tel Aviv, Israel, in conjunction with the European Conference on Information...... Systems (ECIS 2014), and it is part of the activities of the Special Interest Group for eGovernment (SIGeGov) of the Association for Information Systems (AIS)....

Adjuvant and Salvage Radiation Therapy After Prostatectomy: American Society for Radiation Oncology/American Urological Association Guidelines

Energy Technology Data Exchange (ETDEWEB)

Valicenti, Richard K., E-mail: Richard.valicenti@ucdmc.ucdavis.edu [Department of Radiation Oncology, University of California, Davis School of Medicine, Davis, California (United States); Thompson, Ian [Department of Urology, University of Texas Health Science Center at San Antonio, San Antonio, Texas (United States); Albertsen, Peter [Division of Urology, University of Connecticut Health Center, Farmington, Connecticut (United States); Davis, Brian J. [Department of Radiation Oncology, Mayo Medical School, Rochester, Minnesota (United States); Goldenberg, S. Larry [Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia (Canada); Wolf, J. Stuart [Department of Urology, University of Michigan, Ann Arbor, Michigan (United States); Sartor, Oliver [Department of Medicine and Urology, Tulane Medical School, New Orleans, Louisiana (United States); Klein, Eric [Glickman Urological Kidney Institute, Cleveland Clinic, Cleveland, Ohio (United States); Hahn, Carol [Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina (United States); Michalski, Jeff [Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri (United States); Roach, Mack [Department of Radiation Oncology, University of California, San Francisco, San Francisco, California (United States); Faraday, Martha M. [Four Oaks, Inc (United States)

2013-08-01

Purpose: The purpose of this guideline was to provide a clinical framework for the use of radiation therapy after radical prostatectomy as adjuvant or salvage therapy. Methods and Materials: A systematic literature review using PubMed, Embase, and Cochrane database was conducted to identify peer-reviewed publications relevant to the use of radiation therapy after prostatectomy. The review yielded 294 articles; these publications were used to create the evidence-based guideline statements. Additional guidance is provided as Clinical Principles when insufficient evidence existed. Results: Guideline statements are provided for patient counseling, use of radiation therapy in the adjuvant and salvage contexts, defining biochemical recurrence, and conducting a restaging evaluation. Conclusions: Physicians should offer adjuvant radiation therapy to patients with adverse pathologic findings at prostatectomy (ie, seminal vesicle invastion, positive surgical margins, extraprostatic extension) and salvage radiation therapy to patients with prostate-specific antigen (PSA) or local recurrence after prostatectomy in whom there is no evidence of distant metastatic disease. The offer of radiation therapy should be made in the context of a thoughtful discussion of possible short- and long-term side effects of radiation therapy as well as the potential benefits of preventing recurrence. The decision to administer radiation therapy should be made by the patient and the multidisciplinary treatment team with full consideration of the patient's history, values, preferences, quality of life, and functional status. The American Society for Radiation Oncology and American Urological Association websites show this guideline in its entirety, including the full literature review.

Adjuvant and Salvage Radiation Therapy After Prostatectomy: American Society for Radiation Oncology/American Urological Association Guidelines

International Nuclear Information System (INIS)

Valicenti, Richard K.; Thompson, Ian; Albertsen, Peter; Davis, Brian J.; Goldenberg, S. Larry; Wolf, J. Stuart; Sartor, Oliver; Klein, Eric; Hahn, Carol; Michalski, Jeff; Roach, Mack; Faraday, Martha M.

2013-01-01

Purpose: The purpose of this guideline was to provide a clinical framework for the use of radiation therapy after radical prostatectomy as adjuvant or salvage therapy. Methods and Materials: A systematic literature review using PubMed, Embase, and Cochrane database was conducted to identify peer-reviewed publications relevant to the use of radiation therapy after prostatectomy. The review yielded 294 articles; these publications were used to create the evidence-based guideline statements. Additional guidance is provided as Clinical Principles when insufficient evidence existed. Results: Guideline statements are provided for patient counseling, use of radiation therapy in the adjuvant and salvage contexts, defining biochemical recurrence, and conducting a restaging evaluation. Conclusions: Physicians should offer adjuvant radiation therapy to patients with adverse pathologic findings at prostatectomy (ie, seminal vesicle invastion, positive surgical margins, extraprostatic extension) and salvage radiation therapy to patients with prostate-specific antigen (PSA) or local recurrence after prostatectomy in whom there is no evidence of distant metastatic disease. The offer of radiation therapy should be made in the context of a thoughtful discussion of possible short- and long-term side effects of radiation therapy as well as the potential benefits of preventing recurrence. The decision to administer radiation therapy should be made by the patient and the multidisciplinary treatment team with full consideration of the patient's history, values, preferences, quality of life, and functional status. The American Society for Radiation Oncology and American Urological Association websites show this guideline in its entirety, including the full literature review

Effects of processing adjuvants on traditional Chinese herbs

Directory of Open Access Journals (Sweden)

Lin-Lin Chen

2018-04-01

Full Text Available Processing of Chinese medicines is a pharmaceutical technique that transforms medicinal raw materials into decoction pieces for use in different therapies. Various adjuvants, such as vinegar, wine, honey, and brine, are used in the processing to enhance the efficacy and reduce the toxicity of crude drugs. Proper processing is essential to ensure the quality and safety of traditional Chinese medicines (TCMs. Therefore, sound knowledge of processing principles is crucial to the standardized use of these processing adjuvants and to facilitate the production and clinical use of decoction pieces. Many scientific reports have indicated the synergistic effects of processing mechanisms on the chemistry, pharmacology, and pharmacokinetics of the active ingredients in TCMs. Under certain conditions, adjuvants change the content of active or toxic components in drugs by chemical or physical transformation, increase or decrease drug dissolution, exert their own pharmacological effects, or alter drug pharmacokinetics. This review summarizes various processing methods adopted in the last two decades, and highlights current approaches to identify the effects of processing parameters on TCMs. Keywords: Adjuvant, Processing, Synergism, Traditional Chinese medicine

Benefits of adjuvant chemotherapy in high-grade gliomas.

Science.gov (United States)

DeAngelis, Lisa M

2003-12-01

The current standard of care for patients with high-grade glioma is resection followed by radiotherapy. Adjuvant chemotherapy is not widely accepted because of the low sensitivity of gliomas to traditional antineoplastic agents, the poor penetration of most drugs across the blood-brain barrier, and the significant systemic toxicity associated with current agents. However, nitrosoureas and, subsequently, temozolomide (Temodar [US], Temodal [international]; Schering-Plough Corporation, Kenilworth, NJ), a novel alkylating agent, cross the blood-brain barrier and have activity against gliomas. Nitrosoureas have been studied in phase III trials in the adjuvant setting. In individual trials, chemotherapy did not increase median survival but did increase the proportion of patients surviving >/=18 months by 15%. Only with large meta-analyses did the addition of chemotherapy achieve a statistically significant improvement in median survival. Currently there is no means of identifying which patients will benefit from adjuvant chemotherapy, but nitrosoureas and temozolomide are well tolerated in most patients, justifying the administration of adjuvant chemotherapy to all newly diagnosed patients with malignant glioma.

78 FR 18415 - Connected Vehicle Reference Implementation Architecture Workshop; Notice of Public Meeting

Science.gov (United States)

2013-03-26

... DEPARTMENT OF TRANSPORTATION Connected Vehicle Reference Implementation Architecture Workshop...) Intelligent Transportation System Joint Program Office (ITS JPO) will host a free Connected Vehicle Reference... manufacturing, developing, deploying, operating, or maintaining the connected [[Page 18416

Adjuvanted vaccines: Aspects of immunosafety and modes of action

NARCIS (Netherlands)

Aalst, Susan van

2017-01-01

New developments in vaccine design shift towards safe, though sometimes less immunogenic, subunit and synthetic antigens. Therefore, the majority of current vaccines require adjuvants to increase immunogenicity. Most adjuvants available were developed empirically and their mode of action is only

Providing Effective Professional Development for Teachers through the Lunar Workshops for Educators

Science.gov (United States)

Canipe, Marti; Buxner, Sanlyn; Jones, Andrea; Hsu, Brooke; Shaner, Andy; Bleacher, Lora

2014-11-01

In order to integrate current scientific discoveries in the classroom, K-12 teachers benefit from professional development and support. The Lunar Workshops for Educators is a series of weeklong workshops for grade 6-9 science teachers focused on lunar science and exploration, sponsored by the Lunar Reconnaissance Orbiter (LRO) and conducted by the LRO Education and Public Outreach (E/PO) Team. The Lunar Workshops for Educators, have provided this professional development for teachers for the last five years. Program evaluation includes pre- and post- content tests and surveys related to classroom practice, daily surveys, and follow-up surveys conducted during the academic year following the summer workshops to assess how the knowledge and skills learned at the workshop are being used in the classroom. The evaluation of the workshop shows that the participants increased their overall knowledge of lunar science and exploration. Additionally, they gained knowledge about student misconceptions related to the Moon and ways to address those misconceptions. The workshops impacted the ways teachers taught about the Moon by providing them with resources to teach about the Moon and increased confidence in teaching about these topics. Participants reported ways that the workshop impacted their teaching practices beyond teaching about the Moon, encouraging them to include more inquiry and other teaching techniques demonstrated in the workshops in their science classes. Overall, the program evaluation has shown the Lunar Workshops for Educators are effective at increasing teachers’ knowledge about the Moon and use of inquiry-based teaching into their classrooms. Additionally, the program supports participant teachers in integrating current scientific discoveries into their classrooms.

Proceedings of the first geochemical workshop on shale: Environmental Sciences Division publication No. 2845

International Nuclear Information System (INIS)

Brookins, D.G.; Stow, S.H.

1986-12-01

This report represents the outcome of the first workshop dealing with geochemical research needs for a shale-hosted repository for disposal of high-level nuclear waste. The workshop was held at the University of New Mexico in 1985 and was attended by scientists representing academia, national laboratories, and the federal government. Research needs are grouped into three major categories: (1) characterization of baseline conditions, (2) radioelement behavior: ambient conditions, and (3) effect of waste emplacement. Within each category, specific needs are identified and discussed. For each, statements of justification, approach, and man-power requirements are presented. General levels of priorities are established for each research need

Proceedings of the second international workshop on design and construction of final repositories

Energy Technology Data Exchange (ETDEWEB)

Simmons, G R

1995-11-01

Many international radioactive waste disposal programs are in the design and construction phases for underground laboratories and repositories. To provide a forum for discussion Svensk Kaernbraenslehantering AB (SKB) in 1992 initiated an international workshop series in which the organizations considering disposal in hard crystalline rock could meet to discuss issues relevant to The Design and Construction of Final Repositories. The first workshop with the theme `Excavation through water conducting major fracture zones` was hosted by SKB in Saestaholm, Sweden on 1993 March 30 to 31 and the workshop proceedings are SKB Technical Report 94-06. Atomic Energy of Canada Limited hosted the second workshop with the theme `Factors influencing repository design and layout` in Winnipeg, Canada on 1994 February 15 to 17. Thirty-eight people from organizations in eight countries and representative of the European Community participated in the Workshop. This report is the summary of the second workshop. The discussions at the Workshop were recorded and reproduced in the summary. Some editorial license was used to provide the text that follows. The participants were given the opportunity to comment on the text prior to publication. Unfortunately some individual speakers could not be identified on the recording of the Workshop discussions and are labelled `unidentified` in the text. (author).

Proceedings of the second international workshop on design and construction of final repositories

International Nuclear Information System (INIS)

Simmons, G.R.

1995-11-01

Many international radioactive waste disposal programs are in the design and construction phases for underground laboratories and repositories. To provide a forum for discussion Svensk Kaernbraenslehantering AB (SKB) in 1992 initiated an international workshop series in which the organizations considering disposal in hard crystalline rock could meet to discuss issues relevant to The Design and Construction of Final Repositories. The first workshop with the theme 'Excavation through water conducting major fracture zones' was hosted by SKB in Saestaholm, Sweden on 1993 March 30 to 31 and the workshop proceedings are SKB Technical Report 94-06. Atomic Energy of Canada Limited hosted the second workshop with the theme 'Factors influencing repository design and layout' in Winnipeg, Canada on 1994 February 15 to 17. Thirty-eight people from organizations in eight countries and representative of the European Community participated in the Workshop. This report is the summary of the second workshop. The discussions at the Workshop were recorded and reproduced in the summary. Some editorial license was used to provide the text that follows. The participants were given the opportunity to comment on the text prior to publication. Unfortunately some individual speakers could not be identified on the recording of the Workshop discussions and are labelled 'unidentified' in the text. (author)

Lunar Reconnaissance Orbiter Lunar Workshops for Educators

Science.gov (United States)

Jones, A. P.; Hsu, B. C.; Hessen, K.; Bleacher, L.

2012-12-01

contributions to lunar science. Participant feedback on workshop surveys was enthusiastically positive. 2012 was the third and final year for the LWEs in the current funding cycle. They will continue in a modified version at NASA Goddard Space Flight Center in Greenbelt, MD, where the LRO Project Office and Education and Public Outreach Team are based. We will present evaluation results from our external evaluator, and share lessons learned from this workshop series. The LWEs can serve as a model for others interested in incorporating scientist and engineer involvement, data from planetary missions, and data-based activities into a thematic professional development experience for science educators. For more information about the LWEs, please visit http://lunar.gsfc.nasa.gov/lwe/index.html.

From Neurons to Neighborhoods: An Update--Workshop Summary

Science.gov (United States)

Olson, Steve

2012-01-01

"From Neurons to Neighborhoods: An Update: Workshop Summary" is based on the original study "From Neurons to Neighborhoods: Early Childhood Development," which was released in October of 2000. From the time of the original publication's release, much has occurred to cause a fundamental reexamination of the nation's…

77 FR 48107 - Workshop on Performance Assessments of Near-Surface Disposal Facilities: FEPs Analysis, Scenario...

Science.gov (United States)

2012-08-13

...) disposal facilities. The workshop has been developed to facilitate communication among Federal and State.... NRC Public Meeting The purpose of this public meeting is to facilitate communication and gather... Selection and Implementation, Model Abstraction, and Confidence Building Activities The public meeting will...

Workshops as a Research Methodology

Science.gov (United States)

Ørngreen, Rikke; Levinsen, Karin

2017-01-01

This paper contributes to knowledge on workshops as a research methodology, and specifically on how such workshops pertain to e-learning. A literature review illustrated that workshops are discussed according to three different perspectives: workshops as a means, workshops as practice, and workshops as a research methodology. Focusing primarily on…

Public education on sources and effects of radioactive waste disposal

International Nuclear Information System (INIS)

Martin, J.E.; Rengan, K.

1993-01-01

A six-day workshop, developed for providing information on sources and effects of radioactive waste disposal to the general public, is described. The materials were used successfully with a group representing the general public. An extension of the workshop for high school and junior high school science teachers is discussed. (author) 1 tab

Postoperative adjuvant therapy of colorectal carcinoma

International Nuclear Information System (INIS)

Scheithauer, W.

1989-01-01

Evaluating the results of controlled clinical trials, an attempt has been made to summarize the current status of adjuvant therapy in colorectal cancer. Several different adjuvant treatment approaches including immunotherapy, postoperative fibrinolysis, anticoagulation, pre- and postoperative radiotherapy when used as a single modality, have not resulted in any long-term survival benefit. Rather in contrast to previous experiences, recent prospective randomized trials have provided evidence for the efficacy of chemotherapy in the adjuvant treatment of colon and rectal cancer. Whereas its definitive role in the former disease remains somewhat controversial, for rectal cancer, it seems clear that combined modality therapy including polychemotherapy with or without radiation prolongs the disease-free interval, lowers the local recurrence rate, and may improve survival compared to surgery alone. Questions which remain to be answered by future clinical trials are related to the optimal duration and sequence of combined modality, to the role of different radiation sensitizers, and in both colon and rectal cancer, to the choice of the most effective systemtic chemotherapeutic drugs. (orig./MG) [de

Comparison of adjuvants for immune potentiating properties and side effects in mice

NARCIS (Netherlands)

Leenaars, P.P.A.M.; Hendriksen, C.F.M.; Koedam, M.A.; Claassen, I.; Claassen, E.

1995-01-01

Four types of adjuvants were evaluated as alternatives to the use of Freund's complete adjuvant in mice. The adjuvants evaluated included a water-in-oil emulsion (Specol), a microorganism (Lactobacillus), preformed immune-stimulating complexes (ISCOM) containing rabies virus glycoprotein and a

Proceedings: 2nd IEA international workshop on beryllium technology for fusion

Energy Technology Data Exchange (ETDEWEB)

Longhurst, G.R.

1995-09-01

The 2nd IEA International Workshop on Beryllium Technology for Fusion was held September 6--8, 1995 at Jackson Lake Lodge, Wyoming. Forty-four participants took part in the workshop representing Europe, Japan, the Russian Federation, and the United States including representatives from both government laboratories and private industry. The workshop was divided into six technical sessions and a ``town meeting`` panel discussion. Technical sessions addressed the general topics of: Thermomechanical Properties; Manufacturing Technologies; Radiation Effects; Plasma/Tritium Interactions; Safety, Applications, and Design; and Joining and Testing. This volume contains the majority of the papers presented at the workshop. In some instances, the authors of the papers could not be present at the workshop, and the papers were given by others, sometimes in summary form and in some instances combined with others. The full papers are included here in the sequence in which they would have been given. In other instances, presentations were made but no papers were submitted for publication. Those papers do not appear here. In summary, the workshop was very successful. The main objectives of bringing key members of the fusion beryllium community together was certainly met. Forty-four participants registered, and 35 papers were presented. Individual papers are indexed separately on the energy data bases.

Proceedings: 2nd IEA international workshop on beryllium technology for fusion

International Nuclear Information System (INIS)

Longhurst, G.R.

1995-09-01

The 2nd IEA International Workshop on Beryllium Technology for Fusion was held September 6--8, 1995 at Jackson Lake Lodge, Wyoming. Forty-four participants took part in the workshop representing Europe, Japan, the Russian Federation, and the United States including representatives from both government laboratories and private industry. The workshop was divided into six technical sessions and a ''town meeting'' panel discussion. Technical sessions addressed the general topics of: Thermomechanical Properties; Manufacturing Technologies; Radiation Effects; Plasma/Tritium Interactions; Safety, Applications, and Design; and Joining and Testing. This volume contains the majority of the papers presented at the workshop. In some instances, the authors of the papers could not be present at the workshop, and the papers were given by others, sometimes in summary form and in some instances combined with others. The full papers are included here in the sequence in which they would have been given. In other instances, presentations were made but no papers were submitted for publication. Those papers do not appear here. In summary, the workshop was very successful. The main objectives of bringing key members of the fusion beryllium community together was certainly met. Forty-four participants registered, and 35 papers were presented. Individual papers are indexed separately on the energy data bases

Adjuvant treatment and outcomes of stage III endometrial carcinoma

International Nuclear Information System (INIS)

Connell, C.; Ludbrook, J.; Davy, M.; Yeoh, E

2003-01-01

Surgery with staging using FIGO (1988) classification is accepted management for stage III endometrial carcinoma. The delivery of adjuvant therapy is controversial and tends to be individualised. Retrospective review of stage III endometrial carcinoma patients who underwent radical surgery at the Royal Adelaide and Queen Elizabeth Hospitals from 1984 to 2003 was carried out. Medical records were reviewed for details of patient characteristics, surgery, histopathology, adjuvant therapy and recurrence/survival. Sixty-six patients with a median age of 69 (37-97), had a median follow-up of 26 months (1-188 ). For all stage III patients, the actuarial 5-year disease-free and overall survivals were 50 and 43% respectively. Thirty-five patients received pelvic +/- paraaortic radiotherapy, 5 whole abdominal radiotherapy, 14 vaginal brachytherapy boost, 10 chemotherapy and 13 adjuvant hormones. Forty-six percent of patients recurred in a median time of 13 months (0-95). For these patients, the sites of first recurrence were pelvis in 27%, pelvis and abdomen in 23%, abdomen alone in 13%, distant alone in 27%, distant and abdominal in 7% and all three sites in 3%. On univariate analysis disease-free survival was impacted by; age, grade, parametrial involvement, number of extrauterine sites, lymphovascular invasion, adjuvant radiotherapy to the pelvis alone and postoperative macroscopic residual disease. Lymphovascular invasion, post-operative residual disease and adjuvant pelvic radiotherapy remained significant on multivariate analysis. These outcomes for stage III endometrial carcinoma are comparable to the current literature. Ongoing research is required to establish the most appropriate adjuvant therapy in these high risk patients

Proceedings of the workshop on review of dose modeling methods for demonstration of compliance with the radiological criteria for license termination

International Nuclear Information System (INIS)

Nicholson, T.J.; Parrott, J.D.

1998-05-01

The workshop was one in a series to support NRC staff development of guidance for implementing the final rule on ''Radiological Criteria for License Termination.'' The workshop topics included discussion of: dose models used for decommissioning reviews; identification of criteria for evaluating the acceptability of dose models; and selection of parameter values for demonstrating compliance with the final rule. The 2-day public workshop was jointly organized by RES and NMSS staff responsible for reviewing dose modeling methods used in decommissioning reviews. The workshop was noticed in the Federal Register (62 FR 51706). The workshop presenters included: NMSS and RES staff, who discussed both dose modeling needs for licensing reviews, and development of guidance related to dose modeling and parameter selection needs; DOE national laboratory scientists, who provided responses to earlier NRC staff-developed questions and discussed their various Federally-sponsored dose models (i.e., DandD, RESRAD, and MEPAS codes); and an EPA scientist, who presented details on the EPA dose assessment model (i.e., PRESTO code). The workshop was formatted to provide opportunities for the attendees to observe computer demonstrations of the dose codes presented. More than 120 workshop attendees from NRC Headquarters and the Regions, Agreement States; as well as industry representatives and consultants; scientists from EPA, DOD, DNFSB, DOE, and the national laboratories; and interested members of the public participated. A complete transcript of the workshop, including viewgraphs and attendance lists, is available in the NRC Public Document Room. This NUREG/CP documents the formal presentations made during the workshop, and provides a preface outlining the workshop's focus, objectives, background, topics and questions provided to the invited speakers, and those raised during the panel discussion. NUREG/CP-0163 also provides technical bases supporting the development of decommissioning

Cost-utility analysis of adjuvant goserelin (Zoladex and adjuvant chemotherapy in premenopausal women with breast cancer

Directory of Open Access Journals (Sweden)

Cheng Tsui

2012-01-01

Full Text Available Abstract Background Increased health care costs have made it incumbent on health-care facilities and physicians to demonstrate both clinical and cost efficacy when recommending treatments. Though studies have examined the cost-effectiveness of adjuvant goserelin with radiotherapy for locally advanced prostate cancer, few have compared the cost-effectiveness of adjuvant goserelin to adjuvant chemotherapy alone in premenopausal breast cancer. Methods In this retrospective study at one hospital, the records of 152 patients with stage Ia to IIIa ER + breast cancer who received goserelin or chemotherapy were reviewed. Survival analysis was assessed by the Kaplan-Meier method. Patients were interviewed to evaluate their quality of life using the European Organization for Research and Treatment Quality of Life questionnaire (EORTC-QLQ-C30, version 4.0, and to obtain the utility value by the standard gamble (SG and visual scale (VS methods. Total medical cost was assessed from the (National Health Insurance NHI payer's perspective. Results Survival at 11 years was significantly better in the groserelin group (P Conclusions Goserelin therapy results in better survival and higher utility-weighted life-years, and is more cost-effective than TC or TEC chemotherapy.

1997 DOE technical standards program workshop: Proceedings

Energy Technology Data Exchange (ETDEWEB)

NONE

1997-10-01

The Department of Energy held its annual Technical Standards Program Workshop on July 8--10, 1997, at the Loews L`Enfant Plaza Hotel in Washington, DC. The workshop focused on aspects of implementation of the National Technology Transfer and Advancement Act of 1995 [Public Law (PL) 104-113] and the related revision (still pending) to OMB Circular A119 (OMB A119), Federal Participation in the Development and Use of Voluntary Standards. It also addressed DOE`s efforts in transitioning to a standards-based operating culture, and, through this transition, to change from a developer of internal technical standards to a customer of external technical standards. The workshop was designed to provide a forum to better understand how the new law is affecting Department activities. Panel topics such as ``Public Law 104-113 and Its Influence on Federal Agency Standards Activities`` and ``Update on Global Standards Issues`` provided insight on both the internal and external effects of the new law. Keynote speaker Richard Meier of Meadowbrook International (and formerly the Deputy Assistant US Trade Representative) addressed the subject of international trade balance statistics. He pointed out that increases in US export figures do not necessarily indicate increases in employment. Rather, increased employment results from product growth. Mr Meier also discussed issues such as the US migration to the sue of the metric system, the impact of budget limitations on Government participation in voluntary standards organizations, international standards ISO 9000 and ISO 14000, and DOE`s role in the worldwide transition from weapons production to cleanup.

MOOC Design Workshop

DEFF Research Database (Denmark)

Nørgård, Rikke Toft; Mor, Yishay; Warburton, Steven

2016-01-01

For the last two years we have been running a series of successful MOOC design workshops. These workshops build on previous work in learning design and MOOC design patterns. The aim of these workshops is to aid practitioners in defining and conceptualising educational innovations (predominantly......, but not exclusively MOOCs) which are based on an empathic user-centered view of the target learners and teachers. In this paper, we share the main principles, patterns and resources of our workshops and present some initial results for their effectiveness...

Adjuvant Treatment for Older Women with Invasive Breast Cancer

Science.gov (United States)

Jolly, Trevor A; Williams, Grant R; Bushan, Sita; Pergolotti, Mackenzi; Nyrop, Kirsten A; Jones, Ellen L; Muss, Hyman B

2016-01-01

Older women experience a large share of breast cancer incidence and death. With the projected rise in the number of older cancer patients, adjuvant chemo-, radiation and endocrine therapy management will become a key component of breast cancer treatment in older women. Many factors influence adjuvant treatment decisions including patient preferences, life expectancy and tumor biology. Geriatric assessment predicts important outcomes, identifies key deficits, and can aid in the decision making process. This review utilizes clinical vignettes to illustrate core principles in adjuvant management of breast cancer in older women and suggests an approach incorporating life expectancy and geriatric assessment. PMID:26767315

Adjuvants and delivery systems in veterinary vaccinology: current state and future developments

DEFF Research Database (Denmark)

Heegaard, Peter M. H.; Dedieu, Laurence; Johnson, Nicholas

2011-01-01

Modern adjuvants should induce strong and balanced immune responses, and it is often desirable to induce specific types of immunity. As an example, efficient Th1-immunity-inducing adjuvants are highly in demand. Such adjuvants promote good cell-mediated immunity against subunit vaccines that have...

Current adjuvant treatment modalities for gastric cancer: From history to the future

Science.gov (United States)

Kilic, Leyla; Ordu, Cetin; Yildiz, Ibrahim; Sen, Fatma; Keskin, Serkan; Ciftci, Rumeysa; Pilanci, Kezban Nur

2016-01-01

The discrepancy between the surgical technique and the type of adjuvant chemotherapy used in clinical trials and patient outcomes in terms of overall survival rates has led to the generation of different adjuvant treatment protocols in distinct parts of the world. The adjuvant treatment recommendation is generally chemoradiotherapy in the United States, perioperative chemotherapy in the United Kingdom and parts of Europe, and chemotherapy in Asia. These options mainly rely on the United States Intergroup-0116, United Kingdom British Medical Research Council Adjuvant Gastric Infusional Chemotherapy, and the Asian Adjuvant Chemotherapy Trial of S-1 for Gastric Cancer and Capecitabine and Oxaliplatin Adjuvant Study in Stomach Cancer trials. However, the benefits were evident for only certain patients, which were not very homogeneous regarding the type of surgery, chemotherapy regimens, and stage of disease. Whether the dissimilarities in survival are attributable to surgical technique or intrinsic biological differences is a subject of debate. Regardless of the extent of surgery, multimodal therapy may offer modest survival advantage at least for diseases with lymph node involvement. Moreover, in the era of individualized treatment for most of the other cancer types, identification of special subgroups comprising those who will derive more or no benefit from adjuvant therapy merits further investigation. The aim of this review is to reveal the historical evolution and future reflections of adjuvant treatment modalities for resected gastric cancer patients. PMID:27190583

Does adjuvant therapy improve overall survival for stage IA/B pancreatic adenocarcinoma?

Science.gov (United States)

Ostapoff, Katherine T; Gabriel, Emmanuel; Attwood, Kristopher; Kuvshinoff, Boris W; Nurkin, Steven J; Hochwald, Steven N

2017-07-01

Current guidelines recommend adjuvant chemotherapy for resected pancreatic adenocarcinoma (PDAC). However, no studies have addressed its survival benefit for stage I patients as they comprise IA or IB PDAC were identified. Median OS was 60.3 months (mo) for stage IA and 36.9 mo for IB. 45.5% received adjuvant chemotherapy; 19.9% received adjuvant chemoradiation. There was OS benefit for both stage IA/IB patients with adjuvant chemotherapy (HR = 0.73 and 0.76 for IA and IB, respectively, p = 0.002 and IA disease (n = 1,477, 37.8%), age ≥70 (p < 0.001), higher grade (p < 0.001), ≤10 lymph nodes examined (p = 0.008), positive margins (p < 0.001), and receipt of adjuvant chemoradiation (p = 0.002) were associated with worse OS. For stage IB patients (n = 2,432, 62.2%), similar associations were observed with the exception of adjuvant chemoradiation whereby there was no significant association (p = 0.35). Adjuvant chemotherapy was associated with an OS benefit for patients with stage I PDAC; adjuvant chemoradiation was either of no benefit or associated with worse OS. Copyright © 2017 International Hepato-Pancreato-Biliary Association Inc. Published by Elsevier Ltd. All rights reserved.

Some Aspects Of Adjuvant Treatment Of Colorectal Cancer

International Nuclear Information System (INIS)

Hlavata, Z.

2008-01-01

Colorectal cancer is one of the most common cancers in Europe and in North America. Cornerstone of the treatment of localized colorectal cancer is surgical resection followed by chemotherapy or radio-chemotherapy in indicated cases. For patients with Stage III colon cancer recent data have shown efficacy through the combining fluorouracil-based chemotherapy with oxaliplatin into adjuvant treatment program. For patients with Stage II colon cancer, the use of adjuvant chemotherapy remains controversial, but may be appropriate in a subset of individuals at high risk for disease recurrence. Current randomized clinical trials in the adjuvant therapy of colorectal cancer are examining the value of adding agents known to be active in metastatic disease, including those that modify specific molecular targets. (author)

Old and new adjuvants for hepatitis B vaccines.

Science.gov (United States)

Leroux-Roels, Geert

2015-02-01

The safety and immunogenicity profiles of currently available recombinant hepatitis B vaccines are excellent. However, it remains a real challenge to induce protective immunity in the target groups that respond poorly or not at all to conventional vaccines. Ideally, a hepatitis B vaccine can be developed that conveys lifelong protection against infection rapidly after the injection of a single dose. Although this goal is far from being reached, important improvements have been made. Novel vaccine adjuvants have been developed that enhance the immunogenicity of recombinant hepatitis B vaccines while maintaining a good safety profile. The different adjuvants and adjuvant systems that are discussed herein have all been thoroughly evaluated in clinical trials and some have reached or are close to reach the market.

Delivery Mechanisms for Rural Electrification. A report from a workshop

Energy Technology Data Exchange (ETDEWEB)

Gullberg, Monica; Ilskog, Elisabeth; Arvidson, Anders; Katyega, Maneno (eds.)

2004-04-01

The workshop was attended by 28 participants from Kenya, Mozambique South Africa, Sweden, Tanzania, Uganda, Zambia and Zimbabwe, representing energy service providers (private, public and cooperative), consumer groups, public energy authorities, researchers, consultants, NGOs and the Swedish International Development Cooperation Agency. The topic of the workshop was how different types of electricity delivery mechanisms - i.e. the combination of an energy supply technology and the organisation managing it - can support rural development. Which energy services have high priority for rural development? What are the appropriate delivery mechanisms? How can the expansion of different delivery mechanisms be supported and made to work efficiently? These are some of the key questions that were discussed in the workshop. The objectives of the workshop were to share experiences and develop a better understanding of existing and potential energy delivery mechanisms that contribute to development in rural areas in Eastern and Southern Africa. The workshop was targeted at, amongst others, the authorities which are in the process of being formed, or have recently been formed, to take charge of rural electrification such as the Rural Electrification Agencies and Rural Electrification Funds. Four case studies were presented and discussed to provide an introduction to the topic, and concrete examples of different delivery mechanisms were given to inspire the workshop discussions. Focus group discussions were used to explore the participants perceptions and experience of: (i) what rural development is, (ii) what role energy plays in rural development, (iii) which energy services are important for rural development, (iv) which delivery mechanisms are used and appropriate for different situations of energy service delivery in rural areas, and (v) what the institutional framework requirements are for delivering different types of energy services and supporting different types of

77 FR 7136 - Caribbean Fishery Management Council; Public Meetings

Science.gov (United States)

2012-02-10

.../Sedar_Workshops.jsp?WorkshopNum=26 ) 5. Discussion of options paper on parrotfish size and trip limits 6... meetings are open to the public, and will be conducted in English. Simultaneous interpretation (English...

77 FR 25144 - Fisheries of the South Atlantic; South Atlantic Fishery Management Council; Public Meetings

Science.gov (United States)

2012-04-27

.... The Council will consider input from the workgroup and workshops during its June meeting in Orlando... Atlantic; South Atlantic Fishery Management Council; Public Meetings AGENCY: National Marine Fisheries... public meeting and public workshop. SUMMARY: The South Atlantic Fishery Management Council (Council) will...

[Status and suggestions for adjuvant standard for Chinese materia medica processing in China].

Science.gov (United States)

Yang, Chun-Yu; Cao, Hui; Wang, Xiao-Tao; Tu, Jia-Sheng; Qian, Zhong-Zhi; Yu, Zhi-Ling; Shang, Yue; Zhang, Bao-Xian

2017-04-01

In this paper, the status of adjuvant standard for Chinese materia medica processing in the Chinese Pharmacopoeia 2015 edition, the National Specification of Chinese Materia Medica Processing, and the 29 provincial specification of Chinese materia medica was summarized, and the the status including general requirements, specific requirements, and quality standard in the three grade official specifications was collected and analyzed according to the "medicine-adjuvant homology" and "food-adjuvant homology" features of adjuvants. This paper also introduced the research situation of adjuvant standard for Chinese materia medica processing in China; In addition, analyzed and discussed the problems existing in the standard system of adjuvant for Chinese materia medica processing, such as lack of general requirements, low level of standard, inconsistent standard references, and lack of research on the standard, and provided suggestions for the further establishment of the national standards system of adjuvant for Chinese materia medica processing. Copyright© by the Chinese Pharmaceutical Association.

Clinical Practice of Adjuvant Chemotherapy in Patients with Early-Stage Epithelial Ovarian Cancer.

Science.gov (United States)

Frielink, Lindy M J; Pijlman, Brenda M; Ezendam, Nicole P M; Pijnenborg, Johanna M A

2016-01-01

Adjuvant platinum-based chemotherapy improves survival in women with early-stage epithelial ovarian cancer (EOC). Yet, there is a wide variety in clinical practice. All patients diagnosed with FIGO I and IIa EOC (2006-2010) in the south of the Netherlands were analyzed. The percentage of patients that received adjuvant chemotherapy was determined as well as the comprehensiveness of staging and outcome. Forty percent (54/135) of the patients with early-stage EOC received adjuvant chemotherapy. Treatment with adjuvant chemotherapy was associated with FIGO stage, clear-cell histology and nonoptimal staging. Optimal staging was achieved in 50%, and nonoptimal staging was associated with advanced age, comorbidity and treatment in a non-referral hospital. Overall, there was no difference in outcome between patients with and without adjuvant chemotherapy. Yet, in grade 3 tumors, adjuvant chemotherapy seems beneficial. Selective treatment of patients with early-stage EOC might reduce adjuvant chemotherapy without compromising outcome. © 2016 S. Karger AG, Basel.

The Future of Public Health Informatics: Alternative Scenarios and Recommended Strategies

Science.gov (United States)

Edmunds, Margo; Thorpe, Lorna; Sepulveda, Martin; Bezold, Clem; Ross, David A.

2014-01-01

Background: In October 2013, the Public Health Informatics Institute (PHII) and Institute for Alternative Futures (IAF) convened a multidisciplinary group of experts to evaluate forces shaping public health informatics (PHI) in the United States, with the aim of identifying upcoming challenges and opportunities. The PHI workshop was funded by the Robert Wood Johnson Foundation as part of its larger strategic planning process for public health and primary care. Workshop Context: During the two-day workshop, nine experts from the public and private sectors analyzed and discussed the implications of four scenarios regarding the United States economy, health care system, information technology (IT) sector, and their potential impacts on public health in the next 10 years, by 2023. Workshop participants considered the potential role of the public health sector in addressing population health challenges in each scenario, and then identified specific informatics goals and strategies needed for the sector to succeed in this role. Recommendations and Conclusion: Participants developed recommendations for the public health informatics field and for public health overall in the coming decade. These included the need to rely more heavily on intersectoral collaborations across public and private sectors, to improve data infrastructure and workforce capacity at all levels of the public health enterprise, to expand the evidence base regarding effectiveness of informatics-based public health initiatives, and to communicate strategically with elected officials and other key stakeholders regarding the potential for informatics-based solutions to have an impact on population health. PMID:25848630

Systems Engineering Workshops | Wind | NREL

Science.gov (United States)

Workshops Systems Engineering Workshops The Wind Energy Systems Engineering Workshop is a biennial topics relevant to systems engineering and the wind industry. The presentations and agendas are available for all of the Systems Engineering Workshops: The 1st NREL Wind Energy Systems Engineering Workshop

Proceedings of the workshops on 'JAEA project researches at J-PARC/MLF'

International Nuclear Information System (INIS)

Kajimoto, Ryoichi; Maekawa, Fujio; Arima, Hiroshi; Yoshinari, Shizuka; Arai, Masatoshi

2011-06-01

The operation for public use of Materials and Life Science Experimental Facility (MLF) at Japan Proton Accelerator Research Complex (J-PARC) has started since the end of 2008. Rather stable neutron and muon beams at 120 kW are being supplied throughout 2010. Some of the instruments have already produced several good scientific outputs. Furthermore, operation at 200 kW, which exceeds the beam power of the ISIS facility in UK, has started since December 2010. In this promising situation for MLF, we hold three workshops for five neutron instruments which conducted researches for projects by Japan Atomic Energy Agency (JAEA) (project researches): 'Workshop on BL19 (Sep. 29)', 'Workshop on BL04+BL10 (Oct. 28)', and 'Workshop on BL01+BL14 (Oct. 29)'. There, status of the instruments and recent results of the project researches as well as a part of researches by general users were reported, and future directions and issues to be solved of the researches were discussed. This report includes abstracts, materials of the presentations and summary of discussions in the workshops. (author)

Introduction to the risk assessment workshop on indoor air quality

International Nuclear Information System (INIS)

Oezkaynak, H.; Spengler, J.D.

1990-01-01

Due to the emerging importance of the indoor air-quality problem and associated health risk concerns, on December 6-8, 1988 a three-day workshop on indoor air-quality risk assessment was jointly organized by Harvard University, Energy and Environmental Policy Center, and the Harvard School of Public Health. This introduction briefly summarizes the objectives of the workshop and its agenda. The workshop consisted of presentations and discussions by researchers from academic, government, and private institutions. Among the participants were those who have been involved in the design of major field studies of human exposure, physicians and toxicologists involved in clinical studies, human exposure modelers, and epidemiologists and health risk assessors. The overall objective of the workshop was to examine the critical elements needed to perform risk assessments on major indoor air pollutants. Eight pollutants were chosen for discussion: environmental tobacco smoke, formaldehyde, radon, volatile organic compounds, biologicals, man-made mineral fibers, nitrogen dioxide, and semivolatile organic compounds. Twenty-two papers were presented in the workshop. Eight of these papers are published in this issue of Risk Analysis. Nine of the remaining fourteen will shortly be published in the 'Exposure Assessment Section' issue of the Journal of Toxicology and Industrial Health

Postoperative adjuvant chemotherapy in rectal cancer operated for cure.

Science.gov (United States)

Petersen, Sune Høirup; Harling, Henrik; Kirkeby, Lene Tschemerinsky; Wille-Jørgensen, Peer; Mocellin, Simone

2012-03-14

Colorectal cancer is one of the most common types of cancer in the Western world. Apart from surgery - which remains the mainstay of treatment for resectable primary tumours - postoperative (i.e., adjuvant) chemotherapy with 5-fluorouracil (5-FU) based regimens is now the standard treatment in Dukes' C (TNM stage III) colon tumours i.e. tumours with metastases in the regional lymph nodes but no distant metastases. In contrast, the evidence for recommendations of adjuvant therapy in rectal cancer is sparse. In Europe it is generally acknowledged that locally advanced rectal tumours receive preoperative (i.e., neoadjuvant) downstaging by radiotherapy (or chemoradiotion), whereas in the US postoperative chemoradiotion is considered the treatment of choice in all Dukes' C rectal cancers. Overall, no universal consensus exists on the adjuvant treatment of surgically resectable rectal carcinoma; moreover, no formal systematic review and meta-analysis has been so far performed on this subject. We undertook a systematic review of the scientific literature from 1975 until March 2011 in order to quantitatively summarize the available evidence regarding the impact of postoperative adjuvant chemotherapy on the survival of patients with surgically resectable rectal cancer. The outcomes of interest were overall survival (OS) and disease-free survival (DFS). CCCG standard search strategy in defined databases with the following supplementary search. 1. Rect* or colorect* - 2. Cancer or carcinom* or adenocarc* or neoplasm* or tumour - 3. Adjuv* - 4. Chemother* - 5. Postoper* Randomised controlled trials (RCT) comparing patients undergoing surgery for rectal cancer who received no adjuvant chemotherapy with those receiving any postoperative chemotherapy regimen. Two authors extracted data and a third author performed an independent search for verification. The main outcome measure was the hazard ratio (HR) between the risk of event between the treatment arm (adjuvant chemotherapy

The Flower Workshop in psychosocial rehabilitation: a pilot study.

Science.gov (United States)

Pereira, Alfredo; Pereira, Maria Alice Ornellas

2009-01-01

We report a pilot study with the Flower Workshop, a new modality of psychosocial rehabilitation group activity. Cognitive performance in schizophrenia and other mental conditions can be impaired depending on the tasks to be executed and their respective social context. The vulnerability of these individuals can be reduced by means of cognitive and socio-affective facilitation. We conducted a pilot study to introduce the Flower Workshop in a public Mental Health Service in the city of Ribeirão Preto (São Paulo-Brasil) with 12 participants during 18 months (2002-2003). With cognitive and socio-affective facilitation, participants were able to construct vases and make flower arrangements successfully.

Building Public Confidence in Nuclear Activities

International Nuclear Information System (INIS)

Isaacs, T

2002-01-01

Achieving public acceptance has become a central issue in discussions regarding the future of nuclear power and associated nuclear activities. Effective public communication and public participation are often put forward as the key building blocks in garnering public acceptance. A recent international workshop in Finland provided insights into other features that might also be important to building and sustaining public confidence in nuclear activities. The workshop was held in Finland in close cooperation with Finnish stakeholders. This was most appropriate because of the recent successes in achieving positive decisions at the municipal, governmental, and Parliamentary levels, allowing the Finnish high-level radioactive waste repository program to proceed, including the identification and approval of a proposed candidate repository site. Much of the workshop discussion appropriately focused on the roles of public participation and public communications in building public confidence. It was clear that well constructed and implemented programs of public involvement and communication and a sense of fairness were essential in building the extent of public confidence needed to allow the repository program in Finland to proceed. It was also clear that there were a number of other elements beyond public involvement that contributed substantially to the success in Finland to date. And, in fact, it appeared that these other factors were also necessary to achieving the Finnish public acceptance. In other words, successful public participation and communication were necessary but not sufficient. What else was important? Culture, politics, and history vary from country to country, providing differing contexts for establishing and maintaining public confidence. What works in one country will not necessarily be effective in another. Nonetheless, there appear to be certain elements that might be common to programs that are successful in sustaining public confidence and some of

Building Public Confidence in Nuclear Activities

International Nuclear Information System (INIS)

Isaacs, T

2002-01-01

Achieving public acceptance has become a central issue in discussions regarding the future of nuclear power and associated nuclear activities. Effective public communication and public participation are often put forward as the key building blocks in garnering public acceptance. A recent international workshop in Finland provided insights into other features that might also be important to building and sustaining public confidence in nuclear activities. The workshop was held in Finland in close cooperation with Finnish stakeholders. This was most appropriate because of the recent successes in achieving positive decisions at the municipal, governmental, and Parliamentary levels, allowing the Finnish high-level radioactive waste repository program to proceed, including the identification and approval of a proposed candidate repository site Much of the workshop discussion appropriately focused on the roles of public participation and public communications in building public confidence. It was clear that well constructed and implemented programs of public involvement and communication and a sense of fairness were essential in building the extent of public confidence needed to allow the repository program in Finland to proceed. It was also clear that there were a number of other elements beyond public involvement that contributed substantially to the success in Finland to date. And, in fact, it appeared that these other factors were also necessary to achieving the Finnish public acceptance. In other words, successful public participation and communication were necessary but not sufficient. What else was important? Culture, politics, and history vary from country to country, providing differing contexts for establishing and maintaining public confidence. What works in one country will not necessarily be effective in another. Nonetheless, there appear to be certain elements that might be common to programs that are successful in sustaining public confidence, and some of

Forming perceptions and the limits to public participation on ocean commons

DEFF Research Database (Denmark)

Hadjimichael, Maria; Delaney, Alyne

2017-01-01

Public views of, and public participation in, the management of commons are increasingly being recommended and sought after in environmental management processes. Yet, given the limits of today’s liberal democracy, what are the weaknesses? This article presents data from a citizens jury......-inspired deliberative workshop held to tease out stakeholder views of management priorities for a section of the North Sea: the Dogger Bank. As this article reveals, the lessons learned from the Dogger Bank workshop advocate not simply what is required for managing one particular ocean commons, but also highlight some...... of the public participation research design failings, taking public participation in resource management further by adding to the literature and theoretical discussions on the public sphere (Habermas 1989). Analysis of the citizens jury-inspired deliberative workshop also highlights the critical issue of power...

Applied antineutrino physics workshop

International Nuclear Information System (INIS)

Lund, James C.

2008-01-01

This workshop is the fourth one of a series that includes the Neutrino Geophysics Conference at Honolulu, Hawaii, which I attended in 2005. This workshop was organized by the Astro-Particle and Cosmology laboratory in the recently opened Condoret building of the University of Paris. More information, including copies of the presentations, on the workshop is available on the website: www.apc.univ-paris7.fr/AAP2007/. The workshop aims at opening neutrino physics to various fields such that it can be applied in geosciences, nuclear industry (reactor and spent fuel monitoring) and non-proliferation. The workshop was attended by over 60 people from Europe, USA, Asia and Brazil. The meeting was also attended by representatives of the Comprehensive nuclear-Test Ban Treaty (CTBT) and the International Atomic Energy Agency (IAEA). The workshop also included a workshop dinner on board of a river boat sailing the Seine river

Use of chemical and biological adjuvants to achieve the optimum application of radiological techniques

International Nuclear Information System (INIS)

Azab, K.S.

2010-01-01

Nowadays, the optimization and attainment of maximum guarantee are representing the real challenge for the nuclear technology exercise. The Adjuvant techniques might be considered one of the available tactics for the developing, reducing risk and facilitating secure clearing of nuclear waste in the field of radiation technology applications. The history describes the belief that an adjuvant is required for immunity because the immune system evolved to respond to dangerous situations such as infections, and the presence of an adjuvant is the mechanism used to identify these situations. In immunology, an adjuvant is an agent that may stimulate the immune system and increase the response to a vaccine, without having any specific antigenic effect. Adjuvants are coming increasingly into focus for vaccine developers since many novel split and subunit vaccines are insufficiently immunogenic on their own. Among the used today are alum (aluminum hydroxide) and Glycosyl ceramides. It is worth mentioning that manufacturers already had produced thousands of different adjuvants, for both industrial and agricultural purposes. Today, the agricultural and horticultural industries are being overwhelmed by adjuvant choices. Complete Freunds adjuvant is the adjuvant used in animal research studies of basic and applied immunology. (author)

Self-Adjuvanting Glycopeptide Conjugate Vaccine against Disseminated Candidiasis

Science.gov (United States)

Xin, Hong; Cartmell, Jonathan; Bailey, Justin J.; Dziadek, Sebastian; Bundle, David R.; Cutler, Jim E.

2012-01-01

Our research on pathogenesis of disseminated candidiasis led to the discovery that antibodies specific for Candida albicans cell surface β-1, 2–mannotriose [β-(Man)3] protect mice. A 14 mer peptide Fba, which derived from the N-terminal portion of the C. albicans cytosolic/cell surface protein fructose-bisphosphate aldolase, was used as the glycan carrier and resulted in a novel synthetic glycopeptide vaccine β-(Man)3-Fba. By a dendritic cell-based immunization approach, this conjugate induced protective antibody responses against both the glycan and peptide parts of the vaccine. In this report, we modified the β-(Man)3-Fba conjugate by coupling it to tetanus toxoid (TT) in order to improve immunogenicity and allow for use of an adjuvant suitable for human use. By new immunization procedures entirely compatible with human use, the modified β-(Man)3-Fba-TT was administered either alone or as a mixture made with alum or monophosphoryl lipid A (MPL) adjuvants and given to mice by a subcutaneous (s.c.) route. Mice vaccinated with or, surprisingly, without adjuvant responded well by making robust antibody responses. The immunized groups showed a high degree of protection against a lethal challenge with C. albicans as evidenced by increased survival times and reduced kidney fungal burden as compared to control groups that received only adjuvant or DPBS buffer prior to challenge. To confirm that induced antibodies were protective, sera from mice immunized against the β-(Man)3-Fba-TT conjugate transferred protection against disseminated candidiasis to naïve mice, whereas C. albicans-absorbed immune sera did not. Similar antibody responses and protection induced by the β-(Man)3-Fba-TT vaccine was observed in inbred BALB/c and outbred Swiss Webster mice. We conclude that addition of TT to the glycopeptide conjugate results in a self-adjuvanting vaccine that promotes robust antibody responses without the need for additional adjuvant, which is novel and represents a

78 FR 17624 - Wireline Competition Bureau Adds New Discussion Topic To Connect America Cost Model Virtual Workshop

Science.gov (United States)

2013-03-22

... Competition Bureau Adds New Discussion Topic To Connect America Cost Model Virtual Workshop AGENCY: Federal... a new virtual workshop discussion topic, entitled ``Rate of Return for Connect America Cost Model,'' to seek public input on what cost of money should be utilized in the forward-looking cost model that...

Protein antigen adsorption to the DDA/TDB liposomal adjuvant

DEFF Research Database (Denmark)

Hamborg, Mette; Jorgensen, Lene; Bojsen, Anders Riber

2013-01-01

Understanding the nature of adjuvant-antigen interactions is important for the future design of efficient and safe subunit vaccines, but remains an analytical challenge. We studied the interactions between three model protein antigens and the clinically tested cationic liposomal adjuvant composed...... of dimethyldioctadecylammonium (DDA) and trehalose 6,6'-dibehenate (TDB)....

Peer-Review Writing Workshops in College Courses: Students’ Perspectives about Online and Classroom Based Workshops

Directory of Open Access Journals (Sweden)

Erin B. Jensen

2016-11-01

Full Text Available Peer-review workshops are commonly used in writing courses as a way for students to give their peers feedback as well as help their own writing. Most of the research on peer-review workshops focuses on workshops held in traditional in-person courses, with less research on peer-review workshops held online. Students in a freshman writing course experienced both a classroom based writing workshop and an online workshop and then took a survey about their experiences. The majority of the students preferred the online writing workshop because of the convenience of the workshop and being able to post anonymous reviews. Students whom preferred the traditional in-person writing workshop liked being able to talk with their peers about their papers. This research article focuses on the students’ responses and experiences with traditional and online peer-reviews.

Activity of glycated chitosan and other adjuvants to PDT vaccines

Science.gov (United States)

Korbelik, Mladen; Banáth, Judit; Čiplys, Evaldas; Szulc, Zdzislaw; Bielawska, Alicja; Chen, Wei R.

2015-03-01

Glycated chitosan (GC), a water soluble galactose-conjugated natural polysaccharide, has proven to be an effective immunoadjuvant for treatment of tumors based on laser thermal therapy. It was also shown to act as adjuvant for tumor therapy with high-intensity ultrasound and in situ photodynamic therapy (PDT). In the present study, GC was examined as potential adjuvant to PDT-generated cancer vaccine. Two other agents, pure calreticulin protein and acid ceramidase inhibitor LCL521, were also tested as prospective adjuvants for use in conjunction with PDT vaccines. Single treatment with GC, included with PDT vaccine cells suspension, improved the therapeutic efficacy when compared to vaccine alone. This attractive prospect of GC application remains to be carefully optimized and mechanistically elucidated. Both calreticulin and LCL521 proved also effective adjuvants when combined with PDT vaccine tumor treatment.

ICP-MS Workshop

Energy Technology Data Exchange (ETDEWEB)

Carman, April J. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Eiden, Gregory C. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

2014-11-01

This is a short document that explains the materials that will be transmitted to LLNL and DNN HQ regarding the ICP-MS Workshop held at PNNL June 17-19th. The goal of the information is to pass on to LLNL information regarding the planning and preparations for the Workshop at PNNL in preparation of the SIMS workshop at LLNL.

A systematic review and meta-analysis on the safety of newly adjuvanted vaccines among children.

Science.gov (United States)

Stassijns, Jorgen; Bollaerts, Kaatje; Baay, Marc; Verstraeten, Thomas

2016-02-03

New adjuvants such as the AS- or the MF59-adjuvants improve vaccine efficacy and facilitate dose-sparing. Their use in influenza and malaria vaccines has resulted in a large body of evidence on their clinical safety in children. We carried out a systematic search for safety data from published clinical trials on newly adjuvanted vaccines in children ≤10 years of age. Serious adverse events (SAEs), solicited AEs, unsolicited AEs and AEs of special interest were evaluated for four new adjuvants: the immuno-stimulants containing adjuvant systems AS01 and AS02, and the squalene containing oil-in-water emulsions AS03 and MF59. Relative risks (RR) were calculated, comparing children receiving newly adjuvanted vaccines to children receiving other vaccines with a variety of antigens, both adjuvanted and unadjuvanted. Twenty-nine trials were included in the meta-analysis, encompassing 25,056 children who received at least one dose of the newly adjuvanted vaccines. SAEs did not occur more frequently in adjuvanted groups (RR 0.85, 95%CI 0.75-0.96). Our meta-analyses showed higher reactogenicity following administration of newly adjuvanted vaccines, however, no consistent pattern of solicited AEs was observed across adjuvant systems. Pain was the most prevalent AE, but often mild and of short duration. No increased risks were found for unsolicited AEs, febrile convulsions, potential immune mediated diseases and new onset of chronic diseases. Our meta-analysis did not show any safety concerns in clinical trials of the newly adjuvanted vaccines in children ≤10 years of age. An unexplained increase of meningitis in one Phase III AS01-adjuvanted malaria trial and the link between narcolepsy and the AS03-adjuvanted pandemic vaccine illustrate that continued safety monitoring is warranted. Copyright © 2015 Elsevier Ltd. All rights reserved.

The effect of several adjuvants on glufosinate effectiveness in Conyza species.

Science.gov (United States)

Fernandez-Cerejido, M C; Bastida, F; Menendez, J

2009-01-01

The effect of several adjuvants on the effectiveness of glufosinate and the role of adherence and contact angle modifications due to the presence of these adjuvants in the spraying solution on the increase in efficacy observed on the broadleaved weeds Conyza albida and Conyza bonariensis has been determined under laboratory controlled conditions. The adjuvants used on the experiment were a mixture of methyl oleate and palmitate (MO/MP), a dodecylbenzene ammonium sulphonate (DBAS), a paraffinic oil (PO), an alkylglycol ester (AGE), and a lecithin + propionic acid + non ionic surfactant based product (LI-700). Dose-response experiments showed that C. albida displayed higher susceptibility to glufosinate than C. bonariensis, no matter the adjuvant tested. However, none of the mixtures increased the herbicide effectiveness on C. atlbida, with LI 700 and PO showing an antagonistic effect on the herbicide efficacy. On C. bonariensis, MO/MP and DBAS showed significant better results than non-amended glufosinate controls, with LI 700 showing again an antagonistic effect. Both adherence and contact angle studies were inconclusive, since adjuvants with best adherence and contact angle values were not the most effective ones. Therefore, other unknown parameters putatively modified by adjuvants such as herbicide penetration should be questioned.

Trastuzumab-associated cardiac adverse effects in the herceptin adjuvant trial

NARCIS (Netherlands)

Suter, Thomas M.; Procter, Marion; van Veldhuisen, Dirk J.; Muscholl, Michael; Bergh, Jonas; Carlomagno, Chiara; Perren, Timothy; Passalacqua, Rodolfo; Bighin, Claudia; Klijn, Jan G. M.; Ageev, Fail T.; Hitre, Erika; Groetz, Juergen; Iwata, Hiroji; Knap, Malgorzata; Gnant, Michael; Muehlbauer, Susanne; Spence, Alison; Gelber, Richard D.; Piccart-Gebhart, Martine J.

2007-01-01

Purpose The purpose of this analysis was to investigate trastuzumab- associated cardiac adverse effects in breast cancer patients after completion of ( neo) adjuvant chemotherapy with or without radiotherapy. Patients and Methods The Herceptin Adjuvant ( HERA) trial is a three- group, multicenter,

Workshops for the Handicapped; An Annotated Bibliography - No. 6.

Science.gov (United States)

Perkins, Dorothy C., Comp.; And Others

An annotated bibliography of workshops for the handicapped covers the literature on work programs for the period July, 1968 through June, 1969. One hundred and fifty four publications were reviewed; the number of articles on administration, management, and planning of facilities and programs has increased since the last edition. (Author/RJ)

Workshops for state review of site suitability criteria for high-level radioactive waste repositories. Discussion Group reports

International Nuclear Information System (INIS)

1977-10-01

The NRC Waste Management Program and the Office of State Programs held three regional workshops to solicit ideas from State executives and legislators on the siting and licensing procedures for high level waste repositories and to solicit comments on the NRC preliminary site suitability criteria. The workshops were held in Denver, Colorado; New Orleans, Louisiana; and Philadelphia, Pennsylvania during the period 19-30 September 1977. The reports from these workshops are contained herein. The workshops were attended by 170 invited State executives and legislators from 46 states. In addition, there were over 80 observers from diverse backgrounds including the general public, government, industry, professional consultants and university faculty. The workshops were announced in the Federal Register on September 1, 1977

Workshop: Preventing Air Pollution-related Cardiopulmonary Illnesses: Innovative, Cross-disciplinary Solutions

Science.gov (United States)

On Sept. 28-29, 2016 in Washington, DC, EPA’s held its first workshop to share multi-stakeholder perspectives on how to improve cardiopulmonary health outcomes through the integration of environmental health, public health, health care services, data.

Physician Beliefs and Practices for Adjuvant and Salvage Radiation Therapy After Prostatectomy

International Nuclear Information System (INIS)

Showalter, Timothy N.; Ohri, Nitin; Teti, Kristopher G.; Foley, Kathleen A.; Keith, Scott W.; Trabulsi, Edouard J.; Lallas, Costas D.; Dicker, Adam P.; Hoffman-Censits, Jean; Pizzi, Laura T.; Gomella, Leonard G.

2012-01-01

Purpose: Despite results of randomized trials that support adjuvant radiation therapy (RT) after radical prostatectomy (RP) for prostate cancer with adverse pathologic features (APF), many clinicians favor selective use of salvage RT. This survey was conducted to evaluate the beliefs and practices of radiation oncologists (RO) and urologists (U) regarding RT after RP. Methods and Materials: We designed a Web-based survey of post-RP RT beliefs and policies. Survey invitations were e-mailed to a list of 926 RO and 591 U. APF were defined as extracapsular extension, seminal vesicle invasion, or positive surgical margin. Differences between U and RO in adjuvant RT recommendations were evaluated by comparative statistics. Multivariate analyses were performed to evaluate factors predictive of adjuvant RT recommendation. Results: Analyzable surveys were completed by 218 RO and 92 U (overallresponse rate, 20%). Adjuvant RT was recommended based on APF by 68% of respondents (78% RO, 44% U, p <0.001). U were less likely than RO to agree that adjuvant RT improves survival and/or biochemical control (p < 0.0001). PSA thresholds for salvage RT were higher among U than RO (p < 0.001). Predicted rates of erectile dysfunction due to RT were higher among U than RO (p <0.001). On multivariate analysis, respondent specialty was the only predictor of adjuvant RT recommendations. Conclusions: U are less likely than RO to recommend adjuvant RT. Future research efforts should focus on defining the toxicities of post-RP RT and on identifying the subgroups of patients who will benefit from adjuvant vs. selective salvage RT.

Physician Beliefs and Practices for Adjuvant and Salvage Radiation Therapy After Prostatectomy

Energy Technology Data Exchange (ETDEWEB)

Showalter, Timothy N., E-mail: timothy.showalter@jeffersonhospital.org [Department of Radiation Oncology, Jefferson Medical College, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA (United States); Ohri, Nitin; Teti, Kristopher G. [Department of Radiation Oncology, Jefferson Medical College, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA (United States); Foley, Kathleen A. [Strategic Consulting, Thomson Reuters Healthcare, Cambridge, MA (United States); Keith, Scott W. [Division of Biostatistics, Department of Pharmacology and Experimental Therapeutics, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA (United States); Trabulsi, Edouard J.; Lallas, Costas D. [Department of Urology, Jefferson Medical College and Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA (United States); Dicker, Adam P. [Department of Radiation Oncology, Jefferson Medical College, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA (United States); Hoffman-Censits, Jean [Department of Medical Oncology, Jefferson Medical College and Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA (United States); Pizzi, Laura T. [School of Pharmacy, Thomas Jefferson University, Philadelphia, PA (United States); Gomella, Leonard G. [Department of Urology, Jefferson Medical College and Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA (United States)

2012-02-01

Purpose: Despite results of randomized trials that support adjuvant radiation therapy (RT) after radical prostatectomy (RP) for prostate cancer with adverse pathologic features (APF), many clinicians favor selective use of salvage RT. This survey was conducted to evaluate the beliefs and practices of radiation oncologists (RO) and urologists (U) regarding RT after RP. Methods and Materials: We designed a Web-based survey of post-RP RT beliefs and policies. Survey invitations were e-mailed to a list of 926 RO and 591 U. APF were defined as extracapsular extension, seminal vesicle invasion, or positive surgical margin. Differences between U and RO in adjuvant RT recommendations were evaluated by comparative statistics. Multivariate analyses were performed to evaluate factors predictive of adjuvant RT recommendation. Results: Analyzable surveys were completed by 218 RO and 92 U (overallresponse rate, 20%). Adjuvant RT was recommended based on APF by 68% of respondents (78% RO, 44% U, p <0.001). U were less likely than RO to agree that adjuvant RT improves survival and/or biochemical control (p < 0.0001). PSA thresholds for salvage RT were higher among U than RO (p < 0.001). Predicted rates of erectile dysfunction due to RT were higher among U than RO (p <0.001). On multivariate analysis, respondent specialty was the only predictor of adjuvant RT recommendations. Conclusions: U are less likely than RO to recommend adjuvant RT. Future research efforts should focus on defining the toxicities of post-RP RT and on identifying the subgroups of patients who will benefit from adjuvant vs. selective salvage RT.

Workshop Proceedings

DEFF Research Database (Denmark)

2012-01-01

, the main focus there is on spoken languages in their written and spoken forms. This series of workshops, however, offers a forum for researchers focussing on sign languages. For the third time, the workshop had sign language corpora as its main topic. This time, the focus was on the interaction between...... corpus and lexicon. More than half of the papers presented contribute to this topic. Once again, the papers at this workshop clearly identify the potentials of even closer cooperation between sign linguists and sign language engineers, and we think it is events like this that contribute a lot to a better...

77 FR 43827 - International Workshop on Alternative Methods for Leptospira

Science.gov (United States)

2012-07-26

... recent advances and innovations in science and technology that can be applied to Leptospira vaccine... alternative methods. The workshop is open to the public at no charge with attendance limited only by the... priority. Leptospirosis affects numerous animal species including livestock, pets, and wildlife. Vaccines...

77 FR 59930 - Clinical Development Programs for Disease-Modifying Agents for Peripheral Neuropathy; Public...

Science.gov (United States)

2012-10-01

...] Clinical Development Programs for Disease-Modifying Agents for Peripheral Neuropathy; Public Workshop... to the clinical development of disease-modifying agents for the treatment of peripheral neuropathy... disease-modifying products for the management of peripheral neuropathy. Date and Time: The public workshop...

Cognitive function after adjuvant treatment for early breast cancer

DEFF Research Database (Denmark)

Debess, Jeanne; Riis, Jens Østergaard; Engebjerg, Malene Cramer

2010-01-01

The purpose of this study was to examine cognitive function in patients with early breast cancer before and after adjuvant chemotherapy or 6 months of tamoxifen. We performed a population-based study in the county of North Jutland, Denmark, including 120 women aged ... chemotherapy with seven cycles of cyclophosphamide, epirubicin and fluoruracil or adjuvant tamoxifen for 6 months for early breast cancer from 2004 to 2006. They were compared with an aged-matched group of 208 women without previous cancer selected randomly from the same population. Data were collected before...... themselves as impaired at 6 months. Our results do not support that adjuvant chemotherapy is associated with cognitive side effects in breast cancer patients....

Workshop report

African Journals Online (AJOL)

abp

2017-09-14

Sep 14, 2017 ... health: report of first EQUIST training workshop in Nigeria .... The difference between the before and after measurements was ... After the administration of the pre-workshop questionnaire the ... represent Likert rating scale of 1-5 points, where 1point = grossly .... Procedures Manual for the "Evaluating.

Factors Affecting Adjuvant Therapy in Stage III Pancreatic Cancer—Analysis of the National Cancer Database

Directory of Open Access Journals (Sweden)

Mridula Krishnan

2017-08-01

Full Text Available Background: Adjuvant therapy after curative resection is associated with survival benefit in stage III pancreatic cancer. We analyzed the factors affecting the outcome of adjuvant therapy in stage III pancreatic cancer and compared overall survival with different modalities of adjuvant treatment. Methods: This is a retrospective study of patients with stage III pancreatic cancer listed in the National Cancer Database (NCDB who were diagnosed between 2004 and 2012. Patients were stratified based on adjuvant therapy they received. Unadjusted Kaplan-Meier and multivariable Cox regression analysis were performed. Results: We analyzed a cohort included 1731 patients who were recipients of adjuvant therapy for stage III pancreatic cancer within the limits of our database. Patients who received adjuvant chemoradiation had the longest postdiagnosis survival time, followed by patients who received adjuvant chemotherapy, and finally patients who received no adjuvant therapy. On multivariate analysis, advancing age and patients with Medicaid had worse survival, whereas Spanish origin and lower Charlson comorbidity score had better survival. Conclusions: Our study is the largest trial using the NCDB addressing the effects of adjuvant therapy specifically in stage III pancreatic cancer. Within the limits of our study, survival benefit with adjuvant therapy was more apparent with longer duration from date of diagnosis.

Thirteenth Workshop for Computational Fluid Dynamic Applications in Rocket Propulsion and Launch Vehicle Technology. Volume 2

Science.gov (United States)

Williams, R. W. (Compiler)

1996-01-01

This conference publication includes various abstracts and presentations given at the 13th Workshop for Computational Fluid Dynamic Applications in Rocket Propulsion and Launch Vehicle Technology held at the George C. Marshall Space Flight Center April 25-27 1995. The purpose of the workshop was to discuss experimental and computational fluid dynamic activities in rocket propulsion and launch vehicles. The workshop was an open meeting for government, industry, and academia. A broad number of topics were discussed including computational fluid dynamic methodology, liquid and solid rocket propulsion, turbomachinery, combustion, heat transfer, and grid generation.

Application of workshop oriented with new trends of teaching to technical course in chemistry: a partnership between university and public school

Directory of Open Access Journals (Sweden)

Marilde Beatriz Zorzi Sá

2013-08-01

Full Text Available With purpose to provide better training to citizens who have completed high school and they need better training to join the labor market, was created following courses, among them the Technical Course in Chemistry (CTQ. The structure consists of a formation that coordinates work, culture, science and technology as principles that summarize the training process whole. On a visit a public school in Maringá (PR, which implemented the CTQ, it was found that teachers were faced with several difficulties: lack of knowledge in technical skills early, how to articulate theory and practice, shortages of materials and reference theoretical, limitation of laboratories, lack of equipment and difficulties in developing practical activities for the course. Faced with this situation had the idea of support for these teachers and consequently their students. Thus, a group of academics after carry a survey in school in order to known the reality of the course and aspirations of students and teachers, it was developed a workshop with theme generator about the “milk”. These academics develop low-cost materials in aiding the practice of teachers. In addition, further research was conducted to check the results of the activity with the purpose of developing a new workshop looking for teaching strategies to contribute effectively to the course.

Exploring patient experiences of neo-adjuvant chemotherapy for breast cancer.

Science.gov (United States)

Beaver, Kinta; Williamson, Susan; Briggs, Jean

2016-02-01

Neo-adjuvant chemotherapy is recommended for 'inoperable' locally advanced and inflammatory breast cancers. For operable breast cancers, trials indicate no survival differences between chemotherapy given pre or post-surgery. Communicating evidence based information to patients is complex and studies examining patient experiences of neo-adjuvant chemotherapy are lacking. This study aims to explore the experiences of women who received neo-adjuvant chemotherapy for breast cancer. A qualitative approach using in-depth interviews with 20 women who had completed neo-adjuvant chemotherapy for breast cancer. Interview data were analysed using thematic analysis. The sample included a relatively young group of women, with caring responsibilities. Five main themes emerged: coping with the rapid transition from 'well' to 'ill', information needs and decision making, needing support and empathy, impact on family, and creating a new 'normal'. More support was needed towards the end of chemotherapy, when side effects were at their most toxic, and decisions about forthcoming surgery were being made. Some women were referred to psychological services, but usually when a crisis point had been reached. Information and support would have been beneficial at key time points. This information is vital in developing services and interventions to meet the complex needs of these patients and potentially prevent late referral to psychological services. Specialist oncology nurses are able to develop empathetic relationships with patients and have the experience, knowledge and skills to inform and support women experiencing neo-adjuvant chemotherapy. Targeting key time points and maintaining relationship throughout neo-adjuvant chemotherapy would be highly beneficial. Copyright © 2015 Elsevier Ltd. All rights reserved.

Proceedings of the workshop on prospects for research with radioactive beams from heavy ion accelerators

International Nuclear Information System (INIS)

Nitschke, J.M.

1984-04-01

The SuperHILAC Users Executive Committee organized a workshop on Prospects for Research with Radioactive Beams from Heavy Ion Accelerators. The main purpose of the workshop was to bring together a diverse group of scientists who had already done experients with radioactive beams or were interested in their use in the future. The topics of the talks ranged from general nuclear physics, astrophysics, production of radioactive beams and high energy projectile fragmentation to biomedical applications. This publication contains the abstracts of the talks given at the workshop and copies of the viewgraphs as they were supplied to the editor

Public confidence in the management of radioactive waste: the Canadian context

International Nuclear Information System (INIS)

2003-01-01

Public confidence is significantly affected by social considerations, such as public participation in decision-making processes, transparency of activities, access to information, effective and appropriate mitigation measures, development opportunities and social justice issues. In order to increase public confidence, there is a need to fully understand social concerns and to design an effective strategy on how to address them. This is particularly so in relation to radioactive waste management decision making. A workshop held in Ottawa in October 2002 brought together a wide range of Canadian stakeholders to present their views and to debate related issues with delegates from radioactive waste management programmes in 14 countries. This third interactive workshop of the NEA Forum on Stakeholder Confidence focused on key areas such as the social concerns at play in radioactive waste management, how these concerns can be addressed, and development opportunities for local communities. These proceedings provide a summary of the workshop, the full texts of the stakeholder presentations and detailed reports of the workshop discussions. (author)

[Cost-effectiveness analysis of adjuvant anastrozol in post-menopausal women with breast cancer].

Science.gov (United States)

Sasse, Andre Deeke; Sasse, Emma Chen

2009-01-01

Carry out an economic analysis of the incorporation of anastrozole as adjuvant hormone therapy in postmenopausal women with breast cancer in a Brazilian setting. The cost-effectiveness estimate comparing anastrozole to tamoxifen was made from the perspectives of the patient, private health insurance, and government. A Markov model was designed based on data from ATAC trial after 100 months follow-up in a hypothetical cohort of 1000 postmenopausal women in Brazil, using outcomes projections for a 25-year period. Resource utilization and associated costs were obtained from preselected sources and specialists' opinions. Treatment costs varied according to the perspective used. The incremental benefit was inserted in the model to obtain the cost of quality-adjusted life-year gained (QALY). Benefit extrapolations for a 25-year time line showed an estimate of 0.29 QALY gained with anastrozole compared to tamoxifen. The cost-effectiveness ratio per QALY gained depended on which perspective was used. There was an increment of R$ 32.403,00/QALY in the public health system/government, R$ 32.230,00/QALY for private health system, and R$ 55.270,00/QALY for patients. The benefit from adjuvant anastrozole in postmenopausal patients with breast cancer is associated to major differences in cost-effectiveness ratio and varies with the different perspectives. According to current WHO parameters, the increment is considered acceptable under public and private health system perspectives, but not from that of the patient.

Workshops as a Research Methodology

DEFF Research Database (Denmark)

Ørngreen, Rikke; Levinsen, Karin Tweddell

2017-01-01

, and workshops as a research methodology. Focusing primarily on the latter, this paper presents five studies on upper secondary and higher education teachers’ professional development and on teaching and learning through video conferencing. Through analysis and discussion of these studies’ findings, we argue......This paper contributes to knowledge on workshops as a research methodology, and specifically on how such workshops pertain to e-learning. A literature review illustrated that workshops are discussed according to three different perspectives: workshops as a means, workshops as practice...... that workshops provide a platform that can aid researchers in identifying and exploring relevant factors in a given domain by providing means for understanding complex work and knowledge processes that are supported by technology (for example, e-learning). The approach supports identifying factors...

Risk Management Techniques and Practice Workshop Workshop Report

Energy Technology Data Exchange (ETDEWEB)

Quinn, T; Zosel, M

2008-12-02

At the request of the Department of Energy (DOE) Office of Science (SC), Lawrence Livermore National Laboratory (LLNL) hosted a two-day Risk Management Techniques and Practice (RMTAP) workshop held September 18-19 at the Hotel Nikko in San Francisco. The purpose of the workshop, which was sponsored by the SC/Advanced Scientific Computing Research (ASCR) program and the National Nuclear Security Administration (NNSA)/Advanced Simulation and Computing (ASC) program, was to assess current and emerging techniques, practices, and lessons learned for effectively identifying, understanding, managing, and mitigating the risks associated with acquiring leading-edge computing systems at high-performance computing centers (HPCCs). Representatives from fifteen high-performance computing (HPC) organizations, four HPC vendor partners, and three government agencies attended the workshop. The overall workshop findings were: (1) Standard risk management techniques and tools are in the aggregate applicable to projects at HPCCs and are commonly employed by the HPC community; (2) HPC projects have characteristics that necessitate a tailoring of the standard risk management practices; (3) All HPCC acquisition projects can benefit by employing risk management, but the specific choice of risk management processes and tools is less important to the success of the project; (4) The special relationship between the HPCCs and HPC vendors must be reflected in the risk management strategy; (5) Best practices findings include developing a prioritized risk register with special attention to the top risks, establishing a practice of regular meetings and status updates with the platform partner, supporting regular and open reviews that engage the interests and expertise of a wide range of staff and stakeholders, and documenting and sharing the acquisition/build/deployment experience; and (6) Top risk categories include system scaling issues, request for proposal/contract and acceptance testing, and

Adjuvant Therapy for Stage II Colorectal Cancer: Who and with What?

Science.gov (United States)

Chung, Ki-Young Y; Kelsen, David

2006-06-01

The role of adjuvant chemotherapy for patients with stage II colon adenocarcinoma remains controversial. The high surgical cure rate for patients with "low-risk" stage II colon cancer, ranging from 75% to 80%, and the available clinical trials and meta-analyses provide conflicting recommendations for or against adjuvant chemotherapy for this group of patients. For fit "high-risk" stage II patients with clinical obstruction or perforation at presentation, in which the 5-year survival rate is 60% to 70%, there is little controversy, as these patients are routinely treated with adjuvant chemotherapy. Other potential high-risk factors, including high histologic grade, microsatellite instability, and loss of 18q, have yet to be validated in prospective trials. Patients with fewer than 12 regional lymph nodes identified in the surgical specimen have a statistically unclear risk of lymph node involvement. These patients may have stage III disease and should receive adjuvant therapy. The decision to use adjuvant chemotherapy to treat low-risk stage II colon cancer patients (no obstruction or perforation) should be an informed decision weighing the magnitude of a net 2% to 5% survival benefit, a 0.5% to 1.0% risk of mortality with chemotherapy in addition to 6 months of chemotherapy-related toxicities, other coexisting patient morbidities, and the anticipated life expectancy of each patient. As adjuvant chemotherapy is therapy addressing local or metastatic microscopic disease, and the effectiveness of systemic and biologically targeted therapy for advanced macroscopic colon cancer continues to improve rapidly, it remains to be determined by clinical trials whether therapies including newer agents such as cetuximab and bevacizumab administered in the adjuvant setting may affect survival for stage II cancer patients.

Adjuvant whole brain radiotherapy: strong emotions decide but rational studies are needed.

Science.gov (United States)

Brown, Paul D; Asher, Anthony L; Farace, Elana

2008-04-01

Brain metastases are common in cancer patients and cause considerable morbidity and mortality. For patients with limited disease and good performance status, treatment typically involves a combination of focal measures (e.g., surgical resection or radiosurgery) for the radiographically apparent disease, followed by adjuvant whole brain radiotherapy (WBRT) to treat subclinical disease. Because of concerns regarding the toxicity of WBRT, especially neurocognitive deterioration, many have advocated withholding adjuvant WBRT. Recently published studies have shed more light on the efficacy of adjuvant WBRT and the neurocognitive effects of WBRT. However, the inclusion of neurocognitive and quality-of-life data in clinical trials are still required to better define the role of adjuvant WBRT. Currently, two Phase III trials are underway, one in Europe and one in North America, that will determine the effect of adjuvant WBRT on patients' quality of life, neurocognitive function, and survival.

Adjuvant Whole Brain Radiotherapy: Strong Emotions Decide But Rational Studies Are Needed

Energy Technology Data Exchange (ETDEWEB)

Brown, Paul D. [Department of Radiation Oncology, Mayo Clinic, Rochester, MN (United States)], E-mail: brown.paul@mayo.edu; Asher, Anthony L [Brain and Spinal Cord Tumors Programs, Carolinas Medical Center and Presbyterian Hospital, Charlotte, NC (United States); Farace, Elana [Department of Neurosurgery, Pennsylvania State University, Penn State Milton S. Hershey Medical Center, Hershey, PA (United States)

2008-04-01

Brain metastases are common in cancer patients and cause considerable morbidity and mortality. For patients with limited disease and good performance status, treatment typically involves a combination of focal measures (e.g., surgical resection or radiosurgery) for the radiographically apparent disease, followed by adjuvant whole brain radiotherapy (WBRT) to treat subclinical disease. Because of concerns regarding the toxicity of WBRT, especially neurocognitive deterioration, many have advocated withholding adjuvant WBRT. Recently published studies have shed more light on the efficacy of adjuvant WBRT and the neurocognitive effects of WBRT. However, the inclusion of neurocognitive and quality-of-life data in clinical trials are still required to better define the role of adjuvant WBRT. Currently, two Phase III trials are underway, one in Europe and one in North America, that will determine the effect of adjuvant WBRT on patients' quality of life, neurocognitive function, and survival.

Adjuvant Whole Brain Radiotherapy: Strong Emotions Decide But Rational Studies Are Needed

International Nuclear Information System (INIS)

Brown, Paul D.; Asher, Anthony L.; Farace, Elana

2008-01-01

Brain metastases are common in cancer patients and cause considerable morbidity and mortality. For patients with limited disease and good performance status, treatment typically involves a combination of focal measures (e.g., surgical resection or radiosurgery) for the radiographically apparent disease, followed by adjuvant whole brain radiotherapy (WBRT) to treat subclinical disease. Because of concerns regarding the toxicity of WBRT, especially neurocognitive deterioration, many have advocated withholding adjuvant WBRT. Recently published studies have shed more light on the efficacy of adjuvant WBRT and the neurocognitive effects of WBRT. However, the inclusion of neurocognitive and quality-of-life data in clinical trials are still required to better define the role of adjuvant WBRT. Currently, two Phase III trials are underway, one in Europe and one in North America, that will determine the effect of adjuvant WBRT on patients' quality of life, neurocognitive function, and survival

Proceedings of the 3rd international workshop on radiation effects on semiconductor devices for space application

International Nuclear Information System (INIS)

1998-10-01

This publication is the collection of the paper presented at the title workshop. The main purpose of the workshop is to bring the chance for exchange of information between scientists and engineers who work in the field of research and development of semiconductor devices used in strong radiation environment in space. The 27 of the presented papers are indexed individually. (J.P.N.)

Engineering of an Inhalable DDA/TDB Liposomal Adjuvant

DEFF Research Database (Denmark)

Ingvarsson, Pall Thor; Yang, Mingshi; Mulvad, Helle

2013-01-01

The purpose of this study was to identify and optimize spray drying parameters of importance for the design of an inhalable powder formulation of a cationic liposomal adjuvant composed of dimethyldioctadecylammonium (DDA) bromide and trehalose-6,6'-dibehenate (TDB).......The purpose of this study was to identify and optimize spray drying parameters of importance for the design of an inhalable powder formulation of a cationic liposomal adjuvant composed of dimethyldioctadecylammonium (DDA) bromide and trehalose-6,6'-dibehenate (TDB)....

Workshop meeting

International Nuclear Information System (INIS)

Veland, Oeystein

2004-04-01

1-2 September 2003 the Halden Project arranged a workshop on 'Innovative Human-System Interfaces and their Evaluation'. This topic is new in the HRP 2003-2005 programme, and it is important to get feedback from member organizations to the work that is being performed in Halden. It is also essential that relevant activities and experiences in this area from the member organizations are shared with the Halden staff and other HRP members. Altogether 25 persons attended the workshop. The workshop had a mixture of presentations and discussions, and was chaired by Dominique Pirus of EDF, France. Day one focused on the HRP/IFE activities on Human-System Interface design, including Function-oriented displays, Ecological Interface Design, Task-oriented displays, as well as work on innovative display solutions for the oil and gas domain. There were also presentations of relevant work in France, Japan and the Czech Republic. The main focus of day two was the verification and validation of human-system interfaces, with presentations of work at HRP on Human-Centered Validation, Criteria-Based System Validation, and Control Room Verification and Validation. The chairman concluded that it was a successful workshop, although one could have had more time for discussions. The Halden Project got valuable feedback and viewpoints on this new topic during the workshop, and will consider all recommendations related to the future work in this area. (Author)

7th International k0-Users' Workshop

International Nuclear Information System (INIS)

Borut Smodis

2018-01-01

Complete text of publication follows. The k 0 method of neutron activation analysis (k 0 -NAA) has become a well-established analytical tool for elemental analysis of various samples since its introduction in mid-1970s. To strengthen its development, applications and use, a series of regular workshops dedicated to this particular analytical method has been introduced twenty-five years ago, held in Astene, Belgium (1992); Ljubljana, Slovenia (1996); Bruges, Belgium (2001); Funchal, Portugal (2005); Belo Horizonte, Brazil (2009) and Budapest, Hungary (2013). The 7th k 0 -Users' Workshop was held at Hotel Novotel Montreal Centre, Canada, 3-8 September 2017. The meeting was organized by Polytechnique Montreal in cooperation with the International Atomic Energy Agency. Twenty-seven participants from 16 different countries (Australia, Austria, Belgium, Brazil, Canada, Czech Republic, Egypt, Germany, Hungary, Italy, Jamaica, Peru, Slovenia, the Netherlands, Turkey, Vietnam) from all five continents discussed the latest developments and applications of k 0 -NAA. Thirty-three papers were presented in the following sessions: Fundamentals of k 0 -NAA, Nuclear Data, Neutron Flux Parameters, k 0 -NAA Methodology, Validation of k 0 -NAA, Facilities, Automatization, and k 0 -NAA Methodology and PGAA. The talks included presentations by two Keynote Speakers and one Honorary Speaker. During the workshop, scientific visits were paid to the SLOWPOKE NAA Laboratory and Thermal Hydraulics Laboratory of the Polytechnique Montreal. The upcoming 12 papers in this issue of the Journal of Radioanalytical and Nuclear Chemistry were selected to be published from the workshop. The next, 8th k 0 -Users' Workshop is expected to be held in Ljubljana, Slovenia in 2021.

European Workshop on Renewable Rural Energy Applications in North-East Europe

Energy Technology Data Exchange (ETDEWEB)

NONE

1997-12-31

This workshop is a part of the E.C. Thermie B project `Dissemination of Promising Renewable Rural Energy Applications in North-Eastern Europe`. The presentations held in the workshop are collected in this publication. The subjects are: TEKES (Technology Development Centre) Boost Technology; Renewable Energy in Latvia; Rural Renewable energy (Prospects) in Estonia; Renewable energy from Rural Electrification; Techno-Economic Analysis published as a summary; Practical Experiences of Small-Scale Heat Generation from Fuelwood in Finland; Solar systems for Domestic Hot Water and Space Heating; Biomass for Energy: Small-Scale Technologies; Photovoltaic Applications for Rural Areas in the North-East Europe

European Workshop on Renewable Rural Energy Applications in North-East Europe

Energy Technology Data Exchange (ETDEWEB)

NONE

1998-12-31

This workshop is a part of the E.C. Thermie B project `Dissemination of Promising Renewable Rural Energy Applications in North-Eastern Europe`. The presentations held in the workshop are collected in this publication. The subjects are: TEKES (Technology Development Centre) Boost Technology; Renewable Energy in Latvia; Rural Renewable energy (Prospects) in Estonia; Renewable energy from Rural Electrification; Techno-Economic Analysis published as a summary; Practical Experiences of Small-Scale Heat Generation from Fuelwood in Finland; Solar systems for Domestic Hot Water and Space Heating; Biomass for Energy: Small-Scale Technologies; Photovoltaic Applications for Rural Areas in the North-East Europe

77 FR 2556 - Ethical and Regulatory Challenges in the Development of Pediatric Medical Countermeasures; Public...

Science.gov (United States)

2012-01-18

...] Ethical and Regulatory Challenges in the Development of Pediatric Medical Countermeasures; Public Workshop... Administration (FDA), Office of Pediatric Therapeutics, is announcing a public workshop entitled ``Ethical and... provide a forum for careful consideration of scientific, ethical, and regulatory issues confronting FDA...

Aluminium based adjuvants and their effects on mitochondria and lysosomes of phagocytosing cells.

Science.gov (United States)

Ohlsson, Lars; Exley, Christopher; Darabi, Anna; Sandén, Emma; Siesjö, Peter; Eriksson, Håkan

2013-11-01

Aluminium oxyhydroxide, Al(OH)3 is one of few compounds approved as an adjuvant in human vaccines. However, the mechanism behind its immune stimulating properties is still poorly understood. In vitro co-culture of an aluminium adjuvant and the human monocytic cell line THP-1 resulted in reduced cell proliferation. Inhibition occurred at concentrations of adjuvant several times lower than would be found at the injection site using a vaccine formulation containing an aluminium adjuvant. Based on evaluation of the mitochondrial membrane potential, THP-1 cells showed no mitochondrial rupture after co-culture with the aluminium adjuvant, instead an increase in mitochondrial activity was seen. The THP-1 cells are phagocytosing cells and after co-culture with the aluminium adjuvant the phagosomal pathway was obstructed. Primary or early phagosomes mature into phagolysosomes with an internal pH of 4.5 - 5 and carry a wide variety of hydrolysing enzymes. Co-culture with the aluminium adjuvant yielded a reduced level of acidic vesicles and cathepsin L activity, a proteolytic enzyme of the phagolysosomes, was almost completely inhibited. THP-1 cells are an appropriate in vitro model in order to investigate the mechanism behind the induction of a phagocytosing antigen presenting cell into an inflammatory cell by aluminium adjuvants. Much information will be gained by investigating the phagosomal pathway and what occurs inside the phagosomes and to elucidate the ultimate fate of phagocytosed aluminium particles. © 2013.

Space and Architecture's Current Line of Research? A Lunar Architecture Workshop With An Architectural Agenda.

Science.gov (United States)

Solomon, D.; van Dijk, A.

The "2002 ESA Lunar Architecture Workshop" (June 3-16) ESTEC, Noordwijk, NL and V2_Lab, Rotterdam, NL) is the first-of-its-kind workshop for exploring the design of extra-terrestrial (infra) structures for human exploration of the Moon and Earth-like planets introducing 'architecture's current line of research', and adopting an architec- tural criteria. The workshop intends to inspire, engage and challenge 30-40 European masters students from the fields of aerospace engineering, civil engineering, archi- tecture, and art to design, validate and build models of (infra) structures for Lunar exploration. The workshop also aims to open up new physical and conceptual terrain for an architectural agenda within the field of space exploration. A sound introduc- tion to the issues, conditions, resources, technologies, and architectural strategies will initiate the workshop participants into the context of lunar architecture scenarios. In my paper and presentation about the development of the ideology behind this work- shop, I will comment on the following questions: * Can the contemporary architectural agenda offer solutions that affect the scope of space exploration? It certainly has had an impression on urbanization and colonization of previously sparsely populated parts of Earth. * Does the current line of research in architecture offer any useful strategies for com- bining scientific interests, commercial opportunity, and public space? What can be learned from 'state of the art' architecture that blends commercial and public pro- grammes within one location? * Should commercial 'colonisation' projects in space be required to provide public space in a location where all humans present are likely to be there in a commercial context? Is the wave in Koolhaas' new Prada flagship store just a gesture to public space, or does this new concept in architecture and shopping evolve the public space? * What can we learn about designing (infra-) structures on the Moon or any other

Physical exercise during adjuvant chemotherapy

NARCIS (Netherlands)

van Waart, H.

2017-01-01

This thesis evaluates the effect of physical exercise during chemotherapy. In chapter two the study design, rationale and methods of the Physical exercise during Adjuvant Chemotherapy Study (PACES) are described. Chapter three presents the effects of the randomized controlled trial evaluating a

Proceedings: energy from urban wastes workshop, Washington, DC, September 11-12, 1978

Energy Technology Data Exchange (ETDEWEB)

Cohen, A.S.; Brooks, C. (eds.)

1979-06-01

This workshop, for members of public interest groups, was sponsored by DOE's Urban Waste Technology Branch to provide information on the use of urban waste as an energy resource. A separate abstract was prepared for each of seven presentations plus the Summary of discussions. Two acts are included as appendices: (1) Public Law 95-238: Department of Energy Act of 1978 - Civilian Applications; and (2) Public Law 94-580: Resource Conservation and Recovery Act of 1976.

Workshop on establishing institutional credibility for SEAB Task Force on Radioactive Waste Management

International Nuclear Information System (INIS)

1994-01-01

At the request of the Secretary of Energy Advisory Board's Task Force on Civilian Radioactive Waste Management, the National Research Council sponsored a workshop on Establishing Institutional Credibility. The purpose of the workshop was to (1) identify the range of available knowledge regarding the theoretical and conceptual issues of how institutions establish their credibility and legitimacy with key constituents, and (2) to help explore and clarify fundamental concepts in management theory related to these issues. The examination was to include what is known about how organizations establish, maintain, lose, and regain public trust and confidence. There was to be no attempt to develop consensus on these issues or to suggest particular courses of action. The workshop was held on October 24-25, 1991, in Denver, Colorado

Adjuvant Chemoradiation Therapy After Pancreaticoduodenectomy in Elderly Patients With Pancreatic Adenocarcinoma

International Nuclear Information System (INIS)

Horowitz, David P.; Hsu, Charles C.; Wang Jingya; Makary, Martin A.; Winter, Jordan M.; Robinson, Ray; Schulick, Richard D.; Cameron, John L.; Pawlik, Timothy M.; Herman, Joseph M.

2011-01-01

Purpose: To evaluate the efficacy of adjuvant chemoradiation therapy (CRT) for pancreatic adenocarcinoma patients ≥75 years of age. Methods: The study group of 655 patients underwent pancreaticoduodenectomy (PD) for pancreatic adenocarcinoma at the Johns Hopkins Hospital over a 12-year period (8/30/1993 to 2/28/2005). Demographic characteristics, comorbidities, intraoperative data, pathology data, and patient outcomes were collected and analyzed by adjuvant treatment status and age ≥75 years. Cox proportional hazards analysis determined clinical predictors of mortality and morbidity. Results: We identified 166 of 655 (25.3%) patients were ≥75 years of age and 489 of 655 patients (74.7%) were <75 years of age. Forty-nine patients in the elderly group (29.5%) received adjuvant CRT. For elderly patients, node-positive metastases (p = 0.008), poor/anaplastic differentiation (p = 0.012), and undergoing a total pancreatectomy (p = 0.010) predicted poor survival. The 2-year survival for elderly patients receiving adjuvant therapy was improved compared with surgery alone (49.0% vs. 31.6%, p = 0.013); however, 5-year survival was similar (11.7% vs. 19.8%, respectively, p = 0.310). After adjusting for major confounders, adjuvant therapy in elderly patients had a protective effect with respect to 2-year survival (relative risk [RR] 0.58, p = 0.044), but not 5-year survival (RR 0.80, p = 0.258). Among the nonelderly, CRT was significantly associated with 2-year survival (RR 0.60, p < 0.001) and 5-year survival (RR 0.69, p < 0.001), after adjusting for confounders. Conclusions: Adjuvant therapy after PD is significantly associated with increased 2-year but not 5-year survival in elderly patients. Additional studies are needed to select which elderly patients are likely to benefit from adjuvant CRT.

Interactive Forms of Open Scientific and Educational Workshop

Directory of Open Access Journals (Sweden)

Naumova Galina Alekseevna

2014-12-01

Full Text Available The article discusses the innovative chain of the Russian economy which consists of three stages: “Idea” (academic science, “Technology” (applied science, and “Production”. The authors describe the innovative system of Russia in terms of infrastructure devices, the functioning of the financial system and human resources. Special attention is paid to the problem of staff training for the innovation economy in Russia. The authors propose the use of scientific and educational public workshop as a form of interactive courses in training staff for the “economy of knowledge”. The article describes the experience of holding open seminars at the Department of Innovation Studies of Volgograd State University. The members of project teams of scientific and Interdisciplinary Innovative Design educational center take part in these discussions. Four scenarios of public workshops are suggested. The first one refers to the joint research work of students, undergraduates and graduate students. The activity includes the presentation of research projects, collective work of students in the creation of business models, innovative projects, debates in the format of a talk show on current topics in the field of innovation and business. The participants also discuss the latest technological and scientific advances in the field of innovations with practical application in business by means of webinars. The second scenario implies an open workshop in the form of presentation of research results based on the technology of group project-based learning as an interactive method which is widely used in the leading universities of the world, and is the organization of educational process in the form of implementation of group projects, from the stage of their development to practical implementation. Team work (“brainstorming” open workshop consists in the creation of business models, innovative projects based on the use of techniques of prominent

Role of adjuvant radiotherapy in granulosa cell tumors of the ovary.

Science.gov (United States)

Hauspy, Jan; Beiner, Mario E; Harley, Ian; Rosen, Barry; Murphy, Joan; Chapman, William; Le, Lisa W; Fyles, Anthony; Levin, Wilfred

2011-03-01

To review the role of adjuvant radiotherapy (RT) in the outcome and recurrence patterns of granulosa cell tumors (GCTs) of the ovary. The records of all patients with GCTs referred to the Princess Margaret Hospital University Health Network between 1961 and 2006 were retrospectively reviewed. The patient, tumor, and treatment factors were assessed by univariate and multivariate analyses using disease-free survival (DFS) as the endpoint. A total of 103 patients with histologically confirmed GCTs were included in the present study. The mean duration of follow-up was 100 months (range, 1-399). Of the 103 patients, 31 received adjuvant RT. A total of 39 patients developed tumor recurrence. The tumor size, incidence of intraoperative rupture, and presence of concurrent endometrial cancer were not significant risk factors for DFS. The median DFS was 251 months for patients who underwent adjuvant RT compared with 112 months for patients who did not (p=.02). On multivariate analysis, adjuvant RT remained a significant prognostic factor for DFS (p=.004). Of the 103 patients, 12 had died and 44 were lost to follow-up. Ovarian GCTs can be indolent, with patients achieving long-term survival. In our series, adjuvant RT resulted in a significantly longer DFS. Ideally, randomized trials with long-term follow-up are needed to define the role of adjuvant RT for ovarian GCTs. Crown Copyright © 2011. Published by Elsevier Inc. All rights reserved.

[Reform steps toward networking sheltered workshops and the general labour market].

Science.gov (United States)

Wendt, S

2010-02-01

Only 0.16% of disabled employees are enabled to change from sheltered workshops to the general labour market. At the same time the number of disabled employees in sheltered workshops is increasing more than anticipated. Investigations into the growing admissions to sheltered workshops resulted in recommendations to improve the practice of change over. More and more admissions of students having finished special schools could be reduced by improved cooperation between special schools and the local employment market. Special schools should offer suitable job trainings and support students to develop an understanding of the requirements of specific jobs and of their opportunities to develop their skills to do these jobs. In 2009, supported employment has been regulated in social security law, lasting up to three years and aimed at qualifying disabled youngsters for employment in the general labour market instead of entering sheltered workshops. The majority of admissions to sheltered workshops in the meantime concern people with psychological handicaps, with more than 30% however leaving the workshops later on. For this population, "virtual sheltered workshops" are offering more suitable means for reintegration in the general labour market, such as temporary employment in the general labour market or in occupations with small earnings. The personal budget for work is meant to be a model project within the German Länder, to transfer personal support from the sheltered workshop into the general labour market. The conference of German Länder Ministers of Social Affairs has been active since 2007 to develop a concept for reform of the social security law concerning integration assistance for disabled people, which in future is to concentrate on individual needs, removal of obstacles in the law to facilitate the transition from sheltered workshops into the general labour market. The "Deutsche Verein für öffentliche und private Fürsorge" (German association for public

A clinically applicable adjuvant for an atherosclerosis vaccine in mice.

Science.gov (United States)

Kobiyama, Kouji; Vassallo, Melanie; Mitzi, Jessica; Winkels, Holger; Pei, Hong; Kimura, Takayuki; Miller, Jacqueline; Wolf, Dennis; Ley, Klaus

2018-06-22

Vaccination with MHC-II-restricted peptides from Apolipoprotein B (ApoB) with complete and incomplete Freund's adjuvant (CFA/IFA) is known to protect mice from atherosclerosis. This vaccination induces antigen-specific IgG1 and IgG2c antibody responses and a robust CD4 T cell response in lymph nodes. However, CFA/IFA cannot be used in humans. To find a clinically applicable adjuvant, we tested the effect of vaccinating Apoe-deficient mice with ApoB peptide P6 (TGAYSNASSTESASY). In a broad screening experiment, Addavax, a squalene oil similar to MF59, was the only adjuvant that showed similar efficacy as CFA/IFA. This was confirmed in a confirmation experiment for both the aortic arch and whole aorta analyzed by en face analysis after atherosclerotic lesion staining. Mechanistically, restimulated peritoneal cells from mice immunized with P6 in Addavax released significant amounts of IL-10. Unlike P6 in CFA/IFA, vaccination with P6 in Addavax did not induce any detectable IgG1 or IgG2c antibodies to P6. These data suggest that squalene-based adjuvants such as MF59 are good candidate adjuvants for developing a clinically effective atherosclerosis vaccine. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

Adjuvant chemotherapy for gastric cancer: Current evidence and future challenges

Science.gov (United States)

Miceli, Rosalba; Tomasello, Gianluca; Bregni, Giacomo; Di Bartolomeo, Maria; Pietrantonio, Filippo

2014-01-01

Gastric cancer still represents one of the major causes of cancer mortality worldwide. Patients survival is mainly related to stage, with a high proportion of patients with metastatic disease at presentation. Thus, the cure rate largely depend upon surgical resection. Despite the additional, albeit small, benefit of adjuvant chemotherapy has been clearly demonstrated, no general consensus has been reached on the best treatment option. Moreover, the narrow therapeutic index of adjuvant chemotherapy (i.e., limited survival benefit with considerable toxicity) requires a careful assessment of expected risks and benefits for individual patients. Treatment choices vary widely based on the different geographic areas, with chemotherapy alone more often preferred in Europe or Asia and chemoradiotherapy in the United States. In the present review we discuss the current evidence and future challenges regarding adjuvant chemotherapy in curatively resected gastric cancer with particular emphasis on the recently completed landmark studies and meta-analyses. The most recent patient-level meta-analysis demonstrated the benefit of adjuvant chemotherapy over curative surgery; the same Authors also showed that disease-free survival may be used as a surrogate end-point for overall survival. We finally discuss future research issues such as the need of economic evaluations, development of prognostic or predictive biomarkers, and the unmet clinical need of trials comparing perioperative chemotherapy with adjuvant treatment. PMID:24782604

Novel adjuvants & delivery vehicles for vaccines development: a road ahead.

Science.gov (United States)

Mohan, Teena; Verma, Priyanka; Rao, D Nageswara

2013-11-01

The pure recombinant and synthetic antigens used in modern day vaccines are generally less immunogenic than older style live/attenuated and killed whole organism vaccines. One can improve the quality of vaccine production by incorporating immunomodulators or adjuvants with modified delivery vehicles viz. liposomes, immune stimulating complexes (ISCOMs), micro/nanospheres apart from alum, being used as gold standard. Adjuvants are used to augment the effect of a vaccine by stimulating the immune system to respond to the vaccine, more vigorously, and thus providing increased immunity to a particular disease. Adjuvants accomplish this task by mimicking specific sets of evolutionary conserved molecules which include lipopolysaccharides (LPS), components of bacterial cell wall, endocytosed nucleic acids such as dsRNA, ssDNA and unmethylated CpG dinucleotide containing DNA. This review provides information on various vaccine adjuvants and delivery vehicles being developed to date. From literature, it seems that the humoral immune responses have been observed for most adjuvants and delivery platforms while viral-vector, ISCOMs and Montanides have shown cytotoxic T-cell response in the clinical trials. MF59 and MPL® have elicited Th1 responses, and virus-like particles (VLPs), non-degradable nanoparticle and liposomes have also generated cellular immunity. Such vaccine components have also been evaluated for alternative routes of administration with clinical success reported for intranasal delivery of viral-vectors and proteosomes and oral delivery of VLP vaccines.

Development of Novel Protocol for Preclinical Monitoring the Release of Adjuvants Encapsulated Mucosal Delivery Carriers

Directory of Open Access Journals (Sweden)

Mohamed Ibrahim-Saeed

2015-12-01

Full Text Available This work contributes in vaccines down-stream process by introducing a novel platform for in-vitro monitoring of vaccine-adjuvant delivery profile as a crucial preclinical optimizing step in mucosal vaccines. Nano and micro particles of Calcium phosphate (Cap vaccine-adjuvant were encapsulated in Chitosan and Alginate polymeric carriers. Adjuvants release profiles monitored in a permeable bag at 37°C, pH 2, incubated in isotonic buffer for 96 hours. The released Calcium in the outer buffer was monitored and compared in-addition to the carrier’s swelling and biophysical properties. The adjuvants and carriers did not interfere with the proliferation of cultured hepatocytes an indicator of their safe use; Chitosan’s viscosity and swelling were higher than Alginate. Chitosan’s Zeta-potential was significantly high positive, while Cap and Alginate were negative. The prepared CaP and Chitosan particles were in nano-size, while the ready-made CaP adjuvant and Alginate were in micro-size using zeta-seizer and scanning electron-micrograph. The release of nano-size particle was in ascending, extended and controlled manner compared to micro-size adjuvant. Moreover, nano-adjuvant release profile from Chitosan was superior compared to Alginate. The core controlling factors in vaccine-adjuvant sustained release includes; smaller adjuvant particles (nano-size, carrier’s low swelling, high viscosity and importantly carrier-adjuvant entrapment reversibility. Chitosan offers sustained ascending superior capacity in releasing Nano-Cap adjuvant. This novel in-vitro pre-clinical study answer a crucial downstream preparative step for optimizing mucosal vaccines before their direct routine in-vivo trial on animal regardless of adjuvant’s particle size or delivery kinetics.

Consumer and community involvement in health and medical research: evaluation by online survey of Australian training workshops for researchers

OpenAIRE

McKenzie, Anne; Alpers, Kirsten; Heyworth, Jane; Phuong, Cindy; Hanley, Bec

2016-01-01

Plain English Summary In Australia, since 2009, the Consumer and Community Involvement Program (formerly the Consumer and Community Participation Program) has developed and run workshops to help people working in health and medical research involve more consumers (patients) and community members (the public) in their research. In 2012, workshop attendees were invited to do an online survey to find out the effect, if any, that attending a workshop had on their awareness of and attitudes to con...

78 FR 5186 - Clinical Flow Cytometry in Hematologic Malignancies; Public Workshop; Request for Comments

Science.gov (United States)

2013-01-24

... need for such products to assist clinical laboratories in performing this testing. FDA has been working... this workshop include: (1) Overview of Quality control and standardization issues associated with Clinical Flow Cytometry (FCM), including discussion of a NIST traceable standard; (2) Biological controls...

Public understanding of radiation protection concepts

International Nuclear Information System (INIS)

1988-01-01

The Chernobyl accident in April 1986 clearly showed that communication with the public was one of the areas where there was a strong need for improvement, particularly concerning the nature and extent of the information provided by national authorities. The countermeasures adopted by public health authorities also raised difficulties in terms of public understanding and acceptance due, in part, to the perception of discrepancies in national, regional or local response to the accident, but also to a more basic lack of comprehension of the complex radiation protection considerations involved. In an attempt to help improve the situation, the NEA Committee on Radiation Protection and Public Health decided to organise a Workshop on public communication in the event of a nuclear accident, centered on radiation protection issues. The purpose of this Workshop was to analyse appropriate methods and language to be used when explaining to the public the scientific concepts underlying radiation risks and radiation protection, and the technical rationale for the choice of protective actions in an emergency. Separate abstracts were prepared for individual papers presented at the meeting

78 FR 20666 - Food and Drug Administration/National Institutes of Health/National Science Foundation Public...

Science.gov (United States)

2013-04-05

... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2013-N-0345] Food and Drug Administration/National Institutes of Health/ National Science Foundation Public Workshop... public workshop; request for comments. SUMMARY: The Food and Drug Administration (FDA) is announcing its...

Cardiac monitoring during adjuvant trastuzumab therapy: Guideline adherence in clinical practice

NARCIS (Netherlands)

Visser, Annemiek; van de Ven, Eline M. W.; Ruczynski, Larissa I. A.; Blaisse, Reinoud J. B.; van Halteren, Henk K.; Aben, Katja; van Laarhoven, Hanneke W. M.

2016-01-01

Cardiotoxicity is an important adverse effect of adjuvant breast cancer treatment with trastuzumab and three monthly left ventricular ejection fraction (LVEF) monitoring is considered mandatory. The purpose of this study was to gain insight into LVEF monitoring during adjuvant trastuzumab treatment

Randomized trial of adjuvant ovarian suppression in 926 premenopausal patients with early breast cancer treated with adjuvant chemotherapy.

Science.gov (United States)

Arriagada, R; Lê, M G; Spielmann, M; Mauriac, L; Bonneterre, J; Namer, M; Delozier, T; Hill, C; Tursz, T

2005-03-01

The aim of this multicenter trial was to evaluate the role of ovarian suppression in patients with early breast cancer previously treated with local surgery and adjuvant chemotherapy. Nine hundred and twenty-six premenopausal patients with completely resected breast cancer and either axillary node involvement or histological grade 2 or 3 tumors were randomized after surgery to adjuvant chemotherapy alone (control arm) or adjuvant chemotherapy plus ovarian suppression (ovarian suppression arm). Ovarian suppression was obtained by either radiation-induced ovarian ablation or triptorelin for 3 years. The analyses were performed with Cox models stratified by center. Median follow-up was 9.5 years. Mean age was 43 years. Ninety per cent of patients had histologically proven positive axillary nodes, 63% positive hormonal receptors and 77% had received an anthracycline-based chemotherapy regimen. Ovarian suppression was by radiation-induced ovarian ablation (45% of patients) or with triptorelin (48%). At the time of randomization, all patients had regular menses or their follicle-stimulating hormone and estradiol levels indicated a premenopausal status. The 10-year disease-free survival rates were 49% [95% confidence interval (CI) 44% to 54%] in both arms (P = 0.51). The 10-year overall survival rates were 66% (95% CI 61% to 70%) for the ovarian suppression arm and 68% (95% CI 63% to 73%) for the control arm (P = 0.19). There were no variations in the treatment effect according to age, hormonal receptor status or ovarian suppression modality. However, in patients suppression significantly decreased the risk of recurrence (P = 0.01). The results of this trial, after at least 10 years of follow-up, do not favor the use of ovarian suppression after adjuvant chemotherapy. The potential beneficial effect in younger women with hormono-dependent tumors should be further assessed.

Reactor simulator development. Workshop material

International Nuclear Information System (INIS)

2001-01-01

The International Atomic Energy Agency (IAEA) has established a programme in nuclear reactor simulation computer programs to assist its Member States in education and training. The objective is to provide, for a variety of advanced reactor types, insight and practice in reactor operational characteristics and their response to perturbations and accident situations. To achieve this, the IAEA arranges for the supply or development of simulation programs and training material, sponsors training courses and workshops, and distributes documentation and computer programs. This publication consists of course material for workshops on development of such reactor simulators. Participants in the workshops are provided with instruction and practice in the development of reactor simulation computer codes using a model development system that assembles integrated codes from a selection of pre-programmed and tested sub-components. This provides insight and understanding into the construction and assumptions of the codes that model the design and operational characteristics of various power reactor systems. The main objective is to demonstrate simple nuclear reactor dynamics with hands-on simulation experience. Using one of the modular development systems, CASSIM tm , a simple point kinetic reactor model is developed, followed by a model that simulates the Xenon/Iodine concentration on changes in reactor power. Lastly, an absorber and adjuster control rod, and a liquid zone model are developed to control reactivity. The built model is used to demonstrate reactor behavior in sub-critical, critical and supercritical states, and to observe the impact of malfunctions of various reactivity control mechanisms on reactor dynamics. Using a PHWR simulator, participants practice typical procedures for a reactor startup and approach to criticality. This workshop material consists of an introduction to systems used for developing reactor simulators, an overview of the dynamic simulation

Public health aspects of tobacco control revisited

NARCIS (Netherlands)

Gallagher, Jennifer E.; Alajbeg, Ivan; Buechler, Silvia; Carrassi, Antonio; Hovius, Marjolijn; Jacobs, Annelies; Jenner, Maryan; Kinnunen, Taru; Ulbricht, Sabina; Zoitopoulos, Liana

The tobacco epidemic presents a major public health challenge, globally, and within Europe. The aim of the Public Health Work Stream at the 2nd European Workshop on Tobacco Use Prevention and Cessation for Oral Health Professionals was to review the public health aspects of tobacco control and make

2014 Penn State Bioinorganic Workshop

Energy Technology Data Exchange (ETDEWEB)

Golbeck, John [Pennsylvania State Univ., State College, PA (United States)

2015-10-01

The 3rd Penn State Bioinorganic Workshop took place in early June 2014 and was combined with the 3rd Penn State Frontiers in Metallobiochemistry Symposium. The workshop was even larger than the 2nd Penn State Bioinorganic Workshop we offered in 2012. It had even more participants (162 rather than 123 in 2012). Like the 2012 workshop, the 2014 workshop had three parts. The first part consisted of 16 90-minute lectures presented by faculty experts on the topic of their expertise (see below). Based on the suggestions from the 2012 workshop, we have recorded all 16 lectures professionally and make them available to the entire bioinorganic community via online streaming. In addition, hard copies of the recordings are available as backup.

Management of Pediatric Myxopapillary Ependymoma: The Role of Adjuvant Radiation

Energy Technology Data Exchange (ETDEWEB)

Agbahiwe, Harold C.; Wharam, Moody [Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland (United States); Batra, Sachin [Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland (United States); Cohen, Kenneth [Division of Pediatric Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland (United States); Terezakis, Stephanie A., E-mail: sterezak@jhmi.edu [Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland (United States)

2013-02-01

Introduction: Myxopapillary ependymoma (MPE) is a rare tumor in children. The primary treatment is gross total resection (GTR), with no clearly defined role for adjuvant radiation therapy (RT). Published reports, however, suggest that children with MPE present with a more aggressive disease course. The goal of this study was to assess the role of adjuvant RT in pediatric patients with MPE. Methods: Sixteen patients with MPE seen at Johns Hopkins Hospital (JHH) between November 1984 and December 2010 were retrospectively reviewed. Fifteen of the patients were evaluable with a mean age of 16.8 years (range, 12-21 years). Kaplan-Meier curves and descriptive statistics were used for analysis. Results: All patients received surgery as the initial treatment modality. Surgery consisted of either a GTR or a subtotal resection (STR). The median dose of adjuvant RT was 50.4 Gy (range, 45-54 Gy). All patients receiving RT were treated at the involved site. After a median follow-up of 7.2 years (range, 0.75-26.4 years), all patients were alive with stable disease. Local control at 5 and 10 years was 62.5% and 30%, respectively, for surgery alone versus 100% at both time points for surgery and adjuvant RT. Fifty percent of the patients receiving surgery alone had local failure. All patients receiving STR alone had local failure compared to 33% of patients receiving GTR alone. One patient in the surgery and adjuvant RT group developed a distant site of recurrence 1 year from diagnosis. No late toxicity was reported at last follow-up, and neurologic symptoms either improved or remained stable following surgery with or without RT. Conclusions: Adjuvant RT improved local control compared to surgery alone and should be considered after surgical resection in pediatric patients with MPE.

[Critical analysis of reference studies on aluminium-based adjuvants toxicokinetics].

Science.gov (United States)

Masson, J-D; Crépeaux, G; Authier, F-J; Exley, C; Gherardi, R K

2017-07-01

We reviewed the three reference toxicokinetic studies commonly used to suggest innocuity of aluminum (Al)-based adjuvants. A single experimental study was carried out using isotopic 26 Al (Flarend et al., 1997). This study ignored adjuvant cell capture. It was conducted over a short period of time (28 days) and used only two rabbits per adjuvant. At the endpoint, Al retention was 78% for aluminum phosphate and 94% for aluminum hydroxide, both results being incompatible with quick elimination of vaccine-derived Al in urines. Tissue distribution analysis omitted three important retention sites: the injected muscle, the draining lymph node and bone. Two theoretical studies have evaluated the potential risk of vaccine Al in infants, by reference to the oral Minimal Risk Level (MRL) extrapolated from animal studies. Keith et al., 2002 used a too high MRL (2mg/kg/d), an erroneous model of 100% immediate absorption of vaccine Al, and did not consider renal and blood-brain barrier immaturity. Mitkus et al. (2011) only considered absorbed Al, with erroneous calculations of absorption duration. They ignored particulate Al captured by immune cells, which play a role in systemic diffusion and the neuro-inflammatory potential of the adjuvant. MRL they used was both inappropriate (oral Al vs injected adjuvant) and far too high (1mg/kg/d) with regard to experimental studies of Al-induced memory and behavioral changes. Both paucity and serious weaknesses of these studies strongly suggest that novel experimental studies of Al adjuvants toxicokinetics should be performed on the long-term, including post-natal and adult exposures, to ensure innocuity and restore population confidence in Al-containing vaccines. Copyright © 2017 Académie Nationale de Pharmacie. All rights reserved.

Extended Adjuvant Therapy for Breast Cancer

Science.gov (United States)

An NCI Cancer Currents blog on findings from a recent clinical trial which showed that extending adjuvant therapy with an aromatase inhibitor can have important benefits for some women with early-stage cancer.

Request for Travel Funds for Systems Radiation Biology Workshop

Energy Technology Data Exchange (ETDEWEB)

Barcellos-Hoff, Mary Helen [NYU School of Medicine

2014-03-22

The 3rd International Systems Radiation Biology Workshop brought together the major European, US and Japanese research programs on radiation risk as well as selected experts representing systems biological approaches to discuss how the new methodologies could be best exploited for low dose research. A significant part of the workshop was devoted to discussions organised as breakout group sessions. To facilitate discussions number of participants was limited to 60 persons. To achieve the goals of this symposium in this international conference, support from DOE is vital. Hence, this proposal requested support in the amount of $15,000 to cover the travel expenses of international experts and radiation biology scientists from the United States. This supporting mechanism was clearly identified to the selected US participants as a conference support award from the DOE (See attached PDF). The workshop was an outstanding opportunity to strengthen interactions between leading experts in the emerging areas of radiation sciences, and will also provide opportunities for younger scientists to meet with experts and discuss their results. This workshop was designed to endorse active engagement in international collaboration. A major objective of this conference was to effectively communicate research results, in order to ensure that current thinking reflects sound science of radiation biology. Further, this international event addressed the use and success of scientific initiatives in radiation biology for policymakers, standard-setters, and the general public.

INDICO Workshop

CERN Multimedia

CERN. Geneva; Fabbrichesi, Marco

2004-01-01

The INtegrated DIgital COnferencing EU project has finished building a complete software solution to facilitate the MANAGEMENT OF CONFERENCES, workshops, schools or simple meetings from their announcement to their archival. Everybody involved in the organization of events is welcome to join this workshop, in order to understand the scope of the project and to see demonstrations of the various features.

Measuring colorectal cancer care quality for the publicly insured in New York State

International Nuclear Information System (INIS)

Sinclair, Amber H; Schymura, Maria J; Boscoe, Francis P; Yung, Rachel L; Chen, Kun; Roohan, Patrick; Tai, Eric; Schrag, Deborah

2012-01-01

The extent to which concordance with colorectal cancer treatment quality metrics varies by patient characteristics in the publicly insured is not well understood. Our objective was to evaluate the quality of colorectal cancer care for publicly insured residents of New York State (NYS). NYS cancer registry data were linked to Medicaid and Medicare claims and hospital discharge data. We identified colorectal cancer cases diagnosed from 2004 through 2006 and evaluated three treatment quality measures: adjuvant chemotherapy within 4 months of diagnosis for American Joint Cancer Committee (AJCC) stage III colon cancer, adjuvant radiation within 6 months of diagnosis for AJCC stage IIB or III rectal cancer, and adjuvant chemotherapy within 9 months of diagnosis for AJCC stage II–III rectal cancer. Concordance with guidelines was evaluated separately for Medicaid-enrollees under age 65 years and Medicare-enrollees aged 65–79 years. For adjuvant chemotherapy for colon cancer, 79.4% (274/345) of the Medicaid cohort and 71.8% (585/815) of the Medicare cohort were guideline concordant. For adjuvant radiation for rectal cancer, 72.3% (125/173) of the Medicaid cohort and 66.9% (206/308) of the Medicare cohort were concordant. For adjuvant chemotherapy for rectal cancer, 89.5% (238/266) of the Medicaid cohort and 76.0% (392/516) of the Medicare cohort were concordant. Younger age was associated with higher adjusted odds of concordance for all three measures in the Medicare cohort. Racial differences were not evident in either cohort. There is room for improvement in concordance with accepted metrics of cancer care quality. Feedback about performance may assist in targeting efforts to improve care

Adjuvant chemotherapy in soft tissue sarcomas…Conflicts, consensus, and controversies

Directory of Open Access Journals (Sweden)

Jyoti Bajpai

2016-01-01

Full Text Available Soft tissue sarcomas (STSs are an uncommon and diverse group of more than 50 mesenchymal malignancies. Each of these histologic subtypes represents a unique disease with distinct biologic behavior and varying sensitivity to chemotherapy. The judicious use of adjuvant/neoadjuvant chemotherapy along with surgery and radiation in the treatment of localized STS has a role in improving patient outcomes by decreasing local and distant recurrences. There is evidence that the use of adjuvant chemotherapy to a mixed cohort of chemo sensitive and insensitive sarcoma subtypes results in limited benefit. Therefore, it is of paramount importance to identify the subpopulation with high metastatic potential and to identify effective histology-specific treatment options to these patients. Present perspective, will focus on the rationale for adjuvant chemotherapy in sarcoma, with emphasis on the histology driven chemotherapy. It will outline key therapeutic opportunities and hurdles in adjuvant medical treatment of sarcoma, focusing on specific subtypes that are on the verge of new breakthroughs, as well as those in which promise has not lived up to expectations.

NPS Workshop Launches a Continuum of Education, Analysis on the Navy’s Most Challenging Issues

OpenAIRE

Stewart, Kenneth A.

2013-01-01

All information contained herein has been approved for release by the NPS Public Affairs Officer. Students at the Naval Postgraduate School (NPS) recently participated in a warfare innovation workshop designed to challenge students to analyze a series of scenarios wherein U.S. forces are drawn into a conflict in the South China Sea. The university’s warfare innovation workshops, led by the Consortium for Robotics and Unmanned Systems Education and Research (CRUSER), explore adv...

Intraperitoneal P-32 for adjuvant and consolidative therapy in ovarian carcinoma

International Nuclear Information System (INIS)

Condra, Kellie S.; Mendenhall, William M.; Morgan, Linda S.; Freeman, Debra E.; Marcus, Robert B.; Hagan, Michael P.

1996-01-01

Purpose/Objective: To determine the role of intraperitoneal radioactive chromic phosphate (P-32) in the treatment of patients with ovarian carcinoma. Survival results, patterns of recurrence, and treatment morbidity are reported for patients treated adjuvantly after primary surgery and for patients treated with the intent of consolidation after second-look laparotomy. Materials and Methods: Between 1976 and 1993, 25 patients with ovarian carcinoma were treated with 15 mCi P-32 as adjuvant therapy and 43 patients received P-32 as consolidation after second-look laparotomy. The majority of patients (13 of 19) treated adjuvantly had high-risk early-stage disease (IAG 3, IBG 2-3, IC) or more advanced stages (6 patients). Thirty-nine patients received consolidative P-32 after negative second-look laparotomy (35 Stage II-IV and 4 Stage I) and 4 Stage III patients were treated after positive second-look laparotomy. All patients had 2-year minimum follow-up (median, 7.9 years). Results: Ten-year abdominal control and cause-specific survival rates for adjuvant P-32 were 83% and 82%, respectively. For patients treated with consolidative P-32, 5-year abdominal control and cause-specific survival rates were 65% and 78%, respectively. The 5-year cause-specific survival rate for 35 patients with Stage II-IV disease treated with consolidative P-32 after negative second-look laparotomy was 81%. A component of peritoneal failure was the primary mode of recurrence (15 of 22 failures). Four patients required surgical intervention for small-bowel obstruction. No patients died of treatment-related complications. Conclusion: P-32 is well tolerated with acceptable toxicity. In comparing our results to the literature, adjuvant P-32 appears to offer improved cause-specific survival compared with observation alone and equivalent cause-specific survival compared with adjuvant chemotherapy. Consolidative P-32 after negative second-look laparotomy resulted in improved 5-year cause

The QED Workshop

Energy Technology Data Exchange (ETDEWEB)

Pieper, G.W.

1994-07-01

On May 18--20, 1994, Argonne National Laboratory hosted the QED Workshop. The workshop was supported by special funding from the Office of Naval Research. The purpose of the workshop was to assemble of a group of researchers to consider whether it is desirable and feasible to build a proof-checked encyclopedia of mathematics, with an associated facility for theorem proving and proof checking. Among the projects represented were Coq, Eves, HOL, ILF, Imps, MathPert, Mizar, NQTHM, NuPrl, OTTER, Proof Pad, Qu-Prolog, and RRL. Although the content of the QED project is highly technical rigorously proof-checked mathematics of all sorts the discussions at the workshop were rarely technical. No prepared talks or papers were given. Instead, the discussions focused primarily on such political, sociological, practical, and aesthetic questions, such as Why do it? Who are the customers? How can one get mathematicians interested? What sort of interfaces are desirable? The most important conclusion of the workshop was that QED is an idea worthy pursuing, a statement with which virtually all the participants agreed. In this document, the authors capture some of the discussions and outline suggestions for the start of a QED scientific community.

Proceedings of the 3. Workshop on Nuclear Physics in Brazil

International Nuclear Information System (INIS)

1980-01-01

This publication is the final report of the III Workshop on Nuclear Physics in Brazil. Many works were presented on the fields related to Nuclear Physics. It was organized some work groups which discussed the following topics: Perspectivas of Nuclear Physics in Brazil, Personnel Formation and Related Instrumentation. (A.C.A.S.) [pt

Effects of adjuvants on IgG subclasses elicited by virus-like Particles

Directory of Open Access Journals (Sweden)

Visciano Maria Luisa

2012-01-01

Full Text Available Abstract Background Virus-Like Particles (VLPs represent an efficient strategy to present and deliver conformational antigens to the immune system, inducing both arms of the adaptive immune response. Moreover, their particulate structure surrounded by cell membrane provides an adjuvanted effect to VLP-based immunizations. In the present study, the elicitation of different patterns of IgG subclasses by VLPs, administered in CpG ODN1826 or poly(I:C adjuvants, has been evaluated in an animal model. Results Adjuvanted VLPs elicited a higher titer of total specific IgG compared to VLPs alone. Furthermore, while VLPs alone induced a balanced TH2 pattern, VLPs formulated with either adjuvant elicited a TH1-biased IgG subclasses (IgG2a and IgG3, with poly(I:C more potent than CpG ODN1826. Conclusions The results confirmed that adjuvants efficiently improve antigen immunogenicity and represent a suitable strategy to skew the adaptive immune response toward the differentiation of the desired T helper subset, also using VLPs as antigen.

The Blue Dot Workshop: Spectroscopic Search for Life on Extrasolar Planets

Science.gov (United States)

Des Marais, David J. (Editor)

1997-01-01

This workshop explored the key questions and challenges associated with detecting life on an extrasolar planet. The final product will be a NASA Conference Publication which includes the abstracts from 21 talks, summaries of key findings, and recommendations for future research. The workshop included sessions on three related topics: the biogeochemistry of biogenic gases in the atmosphere, the chemistry and spectroscopy of planetary atmospheres, and the remote sensing of planetary atmospheres and surfaces. With the observation that planetary formation is probably a common phenomenon, together with the advent of the technical capability to locate and describe extrasolar planets, this research area indeed has an exciting future.

77 FR 46444 - Gastroenterology Regulatory Endpoints and the Advancement of Therapeutics (GREAT); Public Workshop

Science.gov (United States)

2012-08-03

... discussion of a single relevant disease area. The goal of the workshop day dedicated to eosinophilic... day dedicated to pediatric inflammatory bowel disease (IBD) is to discuss issues related to the extrapolation of efficacy data from adult to pediatric patients, the definition and measurement of treatment...

Proceedings of the second Department Of Energy Defense Programs waste reduction workshop

International Nuclear Information System (INIS)

1989-04-01

The second waste reduction workshop was held at the Rocky Flats Plant (RFP). The objective of this workshop was to exchange specific information (successes and failures) on education and training programs for waste reduction. Each facility was asked to provide a description of their programs to include information on formal, informal, and planned employee training programs; employee incentive programs; pamphlets, posters, books, magazines, communications, and publicity; procurement control and awareness in minimizing hazardous materials; housekeeping successes; waste minimization surveys; and implementation successes and failures. This document contains copies of the demonstrations and not the text of the presentations

ENTRIA workshop: Emotions in the implementation of a final nuclear disposal site

International Nuclear Information System (INIS)

Kattau, Alke

2016-01-01

On 21 June 2016, prior to the publication of the report of the Commission Storage of High Radioactive Waste, ''Emotions in the realisation of a repository for nuclear waste'' were the topic of a workshop. The workshop was organised in the context of the Federal Ministry of Education and Research (BMBF) interdisciplinary research platform ENTRIA. In his opening remarks, Prof.Dr. Ulrich Smeddinck (Institute of Law of the University of Braunschweig) noticed, that emotions have been neglected in the scientific analysis so far, but fears and feelings to be considered with a special view.

Proceedings of the fifth workshop on elementary-particle picture of the universe

International Nuclear Information System (INIS)

Fukugita, Masataka; Suzuki, Atsuto

1991-01-01

The Fifth Workshop on the Elementary-Particle of the Universe was held at Minami-Izu, from 19 to 21, November, 1990. The 80 participants included high-energy physicists, nuclear physicists, cosmic-ray physicists and astrophysicists, both from the theoretic and experimental fields. In this workshop most of the time was given to reviews of the present status and prospects of the subjects of the present project as well as some others, in order to find future directions. A detector symposium was held to explore the applicability of new technologies. This publication collects the presented papers and transparencies. (J.P.N.)

Proceedings of the 2016 Workshop on the Physics and Applications of High Brightness Beams

Science.gov (United States)

Cianchi, Alessandro; Ferrario, Massimo; Musumeci, Pietro; Rosenzweig, James

2017-09-01

We are proud to present the proceedings of the latest in the series of International Committee on Future Accelerators (ICFA)-endorsed workshops on the Physics and Applications of High Brightness Beams, which has been held at the Hotel Nacional in Havana, Cuba between March 28 and April 1, 2016. In total, 135 participants coming from 14 different countries attended this historic conference. In recognition of its pioneering role in the significant blossoming of relations between Cuba and the larger scientific community, this workshop also received the endorsement of UNESCO. The workshop organization was headed by co-chairs Massimo Ferrario (INFN-LNF) and James Rosenzweig (UCLA), with the essential and energetic contributions of local organizing committee chair Fidel Antonio Castro Smirnov (InSTEC, Havana). The workshop scientific agenda was developed under the care of program committee co-chairs Pietro Musumeci (UCLA) and Luca Serafini (INFN-Milano). The publication of the proceedings we present here was led by Alessandro Cianchi (Tor Vergata). Tangible contributions to the workshop infrastructure were received from UCLA, INFN-LNF, InSTEC, EuroNNAC2, and the US National Science Foundation. The workshop web site, which contains detailed information on the scientific agenda of the meeting, is found at https://conferences.pa.ucla.edu/hbb/.

Alternate fusion fuels workshop

International Nuclear Information System (INIS)

1981-06-01

The workshop was organized to focus on a specific confinement scheme: the tokamak. The workshop was divided into two parts: systems and physics. The topics discussed in the systems session were narrowly focused on systems and engineering considerations in the tokamak geometry. The workshop participants reviewed the status of system studies, trade-offs between d-t and d-d based reactors and engineering problems associated with the design of a high-temperature, high-field reactor utilizing advanced fuels. In the physics session issues were discussed dealing with high-beta stability, synchrotron losses and transport in alternate fuel systems. The agenda for the workshop is attached

The Astronomy Workshop

Science.gov (United States)

Hamilton, Douglas P.

2012-05-01

{\\bf The Astronomy Workshop} (http://janus.astro.umd.edu) is a collection of interactive online educational tools developed for use by students, educators, professional astronomers, and the general public. The more than 20 tools in the Astronomy workshop are rated for ease-of-use, and have been extensively tested in large university survey courses as well as more specialized classes for undergraduate majors and graduate students. Here we briefly describe a few of the available tools. {\\bf Solar Systems Visualizer}: The orbital motions of planets, moons, and asteroids in the Solar System as well as many of the planets in exoplanetary systems are animated at their correct relative speeds in accurate to-scale drawings. Zoom in from the chaotic outer satellite systems of the giant planets all the way to their innermost ring systems. {\\bf Solar System Calculators}: These tools calculate a user-defined mathematical expression simultaneously for all of the Solar System's planets (Planetary Calculator) or moons (Satellite Calculator). Key physical and orbital data are automatically accessed as needed. {\\bf Stellar Evolution}: The "Life of the Sun" tool animates the history of the Sun as a movie, showing students how the size and color of our star has evolved and will evolve over billions of years. In "Star Race," the user selects two stars of different masses and watches their evolution in a split-screeen format that emphasizes the great differences in stellar lifetimes and fates.

Benefit of adjuvant chemotherapy in patients with T4 UICC II colon cancer.

Science.gov (United States)

Teufel, Andreas; Gerken, Michael; Hartl, Janine; Itzel, Timo; Fichtner-Feigl, Stefan; Stroszczynski, Christian; Schlitt, Hans Jürgen; Hofstädter, Ferdinand; Klinkhammer-Schalke, Monika

2015-05-20

Colorectal cancer is the third most common cancer and a major cause of morbidity and mortality worldwide. Adjuvant chemotherapy is considered the standard of care in patients with UICC stage III colon cancer after R0 resection. Adjuvant therapy was not shown to be beneficial in patients with UICC stage II colon cancer. However, there is an ongoing discussion as to whether adjuvant chemotherapy may be beneficial for a subgroup of UICC II patients in a "high-risk situation" (such as T4). We investigated a Bavarian population-based (2.1 million inhabitants) cohort of 1937 patients with UICC II CRC treated between 2002 and 2012 in regard of the benefit of adjuvant chemotherapy for large (T4) tumors. Patients older than 80 years of age were excluded. Of 1937 patients, 240 had a T4 tumor (12%); 77 of all T4 patients received postoperative chemotherapy (33%). Kaplan-Meier analysis and Cox regression models were used for survival analyses. Patients with a T4 tumor who received postoperative chemotherapy had a highly significant survival benefit in respect of overall survival (pbenefit from adjuvant treatment. Chemotherapy, age at diagnosis, and tumor grading remained independent risk factors in the multivariate cox regression analysis. Our retrospective study demonstrated the significant benefit of adjuvant chemotherapy in the T4 subgroup of patients with UICC II colon cancer. Our data suggest that adjuvant chemotherapy should be seriously considered in these patients.

The Third ATLAS ROD Workshop

CERN Multimedia

Poggioli, L.

A new-style Workshop After two successful ATLAS ROD Workshops dedicated to the ROD hardware and held at the Geneva University in 1998 and in 2000, a new style Workshop took place at LAPP in Annecy on November 14-15, 2002. This time the Workshop was fully dedicated to the ROD-TDAQ integration and software in view of the near future integration activities of the final RODs for the detector assembly and commissioning. More precisely, the aim of this workshop was to get from the sub-detectors the parameters needed for T-DAQ, as well as status and plans from ROD builders. On the other hand, what was decided and assumed had to be stated (like EB decisions and URDs), and also support plans. The Workshop gathered about 70 participants from all ATLAS sub-detectors and the T-DAQ community. The quite dense agenda allowed nevertheless for many lively discussions, and for a dinner in the old town of Annecy. The Sessions The Workshop was organized in five main sessions: Assumptions and recommendations Sub-de...

Technology transfer of oil-in-water emulsion adjuvant manufacturing for pandemic influenza vaccine production in Romania: Preclinical evaluation of split virion inactivated H5N1 vaccine with adjuvant.

Science.gov (United States)

Stavaru, Crina; Onu, Adrian; Lupulescu, Emilia; Tucureanu, Catalin; Rasid, Orhan; Vlase, Ene; Coman, Cristin; Caras, Iuliana; Ghiorghisor, Alina; Berbecila, Laurentiu; Tofan, Vlad; Bowen, Richard A; Marlenee, Nicole; Hartwig, Airn; Bielefeldt-Ohmann, Helle; Baldwin, Susan L; Van Hoeven, Neal; Vedvick, Thomas S; Huynh, Chuong; O'Hara, Michael K; Noah, Diana L; Fox, Christopher B

2016-04-02

Millions of seasonal and pandemic influenza vaccine doses containing oil-in-water emulsion adjuvant have been administered in order to enhance and broaden immune responses and to facilitate antigen sparing. Despite the enactment of a Global Action Plan for Influenza Vaccines and a multi-fold increase in production capabilities over the past 10 years, worldwide capacity for pandemic influenza vaccine production is still limited. In developing countries, where routine influenza vaccination is not fully established, additional measures are needed to ensure adequate supply of pandemic influenza vaccines without dependence on the shipment of aid from other, potentially impacted first-world countries. Adaptation of influenza vaccine and adjuvant technologies by developing country influenza vaccine manufacturers may enable antigen sparing and corresponding increases in global influenza vaccine coverage capacity. Following on previously described work involving the technology transfer of oil-in-water emulsion adjuvant manufacturing to a Romanian vaccine manufacturing institute, we herein describe the preclinical evaluation of inactivated split virion H5N1 influenza vaccine with emulsion adjuvant, including immunogenicity, protection from virus challenge, antigen sparing capacity, and safety. In parallel with the evaluation of the bioactivity of the tech-transferred adjuvant, we also describe the impact of concurrent antigen manufacturing optimization activities. Depending on the vaccine antigen source and manufacturing process, inclusion of adjuvant was shown to enhance and broaden functional antibody titers in mouse and rabbit models, promote protection from homologous virus challenge in ferrets, and facilitate antigen sparing. Besides scientific findings, the operational lessons learned are delineated in order to facilitate adaptation of adjuvant technologies by other developing country institutes to enhance global pandemic influenza preparedness.

Melatonin and Fertoprotective Adjuvants: Prevention against Premature Ovarian Failure during Chemotherapy.

Science.gov (United States)

Jang, Hoon; Hong, Kwonho; Choi, Youngsok

2017-06-07

Premature ovarian failure is one of the side effects of chemotherapy in pre-menopausal cancer patients. Preservation of fertility has become increasingly important in improving the quality of life of completely recovered cancer patients. Among the possible strategies for preserving fertility such as ovarian tissue cryopreservation, co-treatment with a pharmacological adjuvant is highly effective and poses less of a burden on the human body. Melatonin is generally produced in various tissues and acts as a universally acting antioxidant in cells. Melatonin is now more widely used in various biological processes including treating insomnia and an adjuvant during chemotherapy. In this review, we summarize the information indicating that melatonin may be useful for reducing and preventing premature ovarian failure in chemotherapy-treated female patients. We also mention that many adjuvants other than melatonin are developed and used to inhibit chemotherapy-induced infertility. This information will give us novel insights on the clinical use of melatonin and other agents as fertoprotective adjuvants for female cancer patients.

Emergency response workers workshop

International Nuclear Information System (INIS)

Agapeev, S.A.; Glukhikh, E.N.; Tyurin, R.L.

2012-01-01

A training workshop entitled Current issues and potential improvements in Rosatom Corporation emergency prevention and response system was held in May-June, 2012. The workshop combined theoretical training with full-scale practical exercise that demonstrated the existing innovative capabilities for radiation reconnaissance, diving equipment and robotics, aircraft, emergency response and rescue hardware and machinery. This paper describes the activities carried out during the workshop [ru

Effect of different adjuvant formulations on the immunogenicity and protective effect of a live Mycoplasma hyopneumoniae vaccine after intramuscular inoculation.

Science.gov (United States)

Xiong, Qiyan; Wei, Yanna; Xie, Haidong; Feng, Zhixin; Gan, Yuan; Wang, Chunlai; Liu, Maojun; Bai, Fangfang; Xie, Fang; Shao, Guoqing

2014-06-05

Mycoplasma hyopneumoniae (M. hyopneumoniae) vaccine strain 168 is an intrapulmonically injected attenuated live vaccine that is available in the Chinese market. The aim of this study was to develop suitable adjuvants for this live vaccine to provide effective protection after intramuscular inoculation. Several adjuvant components were screened to assess their toxicity for the live vaccine, and various adjuvant formulations were then designed and prepared. Vaccines supplemented with these adjuvants were used to immunize mice intramuscularly to assess the capacity of the adjuvants to induce a specific immune response. The screened formulations were then evaluated in pigs. Seven of the eight adjuvant components did not affect the viability of the live vaccine, and seven different adjuvant formulations were then designed. In mice, the ISCOM-matrix adjuvant and the levamisole-chitosan mixture adjuvant significantly enhanced serum IgG responses against M. hyopneumoniae, while lymphocyte proliferation was enhanced by the ISCOM-matrix adjuvant, the carbomer-astragalus polysaccharide mixture adjuvant and an oil-in-water emulsion adjuvant. These four adjuvants were evaluated in pigs. Enhancement of specific lymphocyte proliferation responses was observed in the groups vaccinated with the ISCOM-matrix adjuvant and the carbomer-astragalus polysaccharide mixture adjuvant. Significant enhancement of serum IgG antibody production was observed before challenge in pigs vaccinated with the carbomer-astragalus polysaccharide mixture adjuvant and the levamisole-chitosan mixture adjuvant, while after challenge, all of the animals that received vaccines containing adjuvants had higher antibody concentrations against M. hyopneumoniae than unvaccinated animals. Animals inoculated with a vaccine containing the ISCOM-matrix adjuvant (median score 3.57) or the carbomer-astragalus polysaccharide mixture adjuvant (median score 5.28) had reduced lesion scores compared to unvaccinated animals

EDITORIAL: 15th European Workshop on Micromechanics (MME)

Science.gov (United States)

Puers, Bob

2005-07-01

This special issue of Journal of Micromechanics and Microengineering is entirely devoted to the fifteenth European Workshop on Micromechanics (MME), which was held in Leuven, at the Faculty Club, 5-7 September 2004. In this issue you will find a selection of papers presented at this workshop. The MME Workshop is organized every year to gather mostly European scientists and people from industry to discuss topics related to micromachining and microengineering in an informal manner. The first workshop was held at Twente University, the Netherlands, in 1989. The success of that event inaugurated a series of workshops traveling all over Europe. Looking back on the fifteen years of micromachining it is evident that the field has become more mature. More application driven research is now replacing the basic pure technology driven research we once got so excited about. Yet, half of the contributions still cover problems related to fabrication, production and reliability. Traditionally, the workshop aims to bring together young scientists in the field, with emphasis on discussions and communications in a friendly and informal atmosphere. The goal is to stimulate and to improve knowledge in the field, as well as to promote friendships between researchers. This edition of the workshop was no different. More than 70 papers were contributed, and it was decided to widen the scope with contributions also covering non-silicon technologies. This trend had already been informally introduced some years ago. After the third edition, it was decided to open up a selection of the contributed papers to a broader public by publishing them in a special issue of Journal of Micromechanics and Microengineering, and this has continued to the present day. Since the purpose of the workshop clearly is to stimulate younger scientists to enter the field, even immature research is presented there. The selection in this issue, however, aims to bring to you the more advanced level research work. Even

Designing CAF-adjuvanted dry powder vaccines: spray drying preserves the adjuvant activity of CAF01.

Science.gov (United States)

Ingvarsson, Pall Thor; Schmidt, Signe Tandrup; Christensen, Dennis; Larsen, Niels Bent; Hinrichs, Wouter Leonardus Joseph; Andersen, Peter; Rantanen, Jukka; Nielsen, Hanne Mørck; Yang, Mingshi; Foged, Camilla

2013-05-10

Dry powder vaccine formulations are highly attractive due to improved storage stability and the possibility for particle engineering, as compared to liquid formulations. However, a prerequisite for formulating vaccines into dry formulations is that their physicochemical and adjuvant properties remain unchanged upon rehydration. Thus, we have identified and optimized the parameters of importance for the design of a spray dried powder formulation of the cationic liposomal adjuvant formulation 01 (CAF01) composed of dimethyldioctadecylammonium (DDA) bromide and trehalose 6,6'-dibehenate (TDB) via spray drying. The optimal excipient to stabilize CAF01 during spray drying and for the design of nanocomposite microparticles was identified among mannitol, lactose and trehalose. Trehalose and lactose were promising stabilizers with respect to preserving liposome size, as compared to mannitol. Trehalose and lactose were in the glassy state upon co-spray drying with the liposomes, whereas mannitol appeared crystalline, suggesting that the ability of the stabilizer to form a glassy matrix around the liposomes is one of the prerequisites for stabilization. Systematic studies on the effect of process parameters suggested that a fast drying rate is essential to avoid phase separation and lipid accumulation at the surface of the microparticles during spray drying. Finally, immunization studies in mice with CAF01 in combination with the tuberculosis antigen Ag85B-ESAT6-Rv2660c (H56) demonstrated that spray drying of CAF01 with trehalose under optimal processing conditions resulted in the preservation of the adjuvant activity in vivo. These data demonstrate the importance of liposome stabilization via optimization of formulation and processing conditions in the engineering of dry powder liposome formulations. Copyright © 2013 Elsevier B.V. All rights reserved.

2015 Inverter Workshop | Photovoltaic Research | NREL

Science.gov (United States)

Inverter Workshop 2015 Inverter Workshop Wednesday, February 25, 2015 Chair: Jack Flicker In about inverters. This workshop represented a follow-on to the inverter workshops that Sandia National conversations between module and inverter experts. Agenda For a detailed schedule of the day's events, access

First International Workshop on Grid Simulator Testing of Wind Turbine Drivetrains: Workshop Proceedings

Energy Technology Data Exchange (ETDEWEB)

Gevorgian, V.; Link, H.; McDade, M.; Mander, A.; Fox, J. C.; Rigas, N.

2013-11-01

This report summarizes the proceedings of the First International Workshop on Grid Simulator Testing of Wind Turbine Drivetrains, held from June 13 to 14, 2013, at the National Renewable Energy Laboratory's National Wind Technology Center, located south of Boulder, Colorado. The workshop was sponsored by the U.S. Department of Energy and cohosted by the National Renewable Energy Laboratory and Clemson University under ongoing collaboration via a cooperative research and development agreement. The purpose of the workshop was to provide a forum to discuss the research, testing needs, and state-of-the-art apparatuses involved in grid compliance testing of utility-scale wind turbine generators. This includes both dynamometer testing of wind turbine drivetrains ('ground testing') and field testing grid-connected wind turbines. Four sessions followed by discussions in which all attendees of the workshop were encouraged to participate comprised the workshop.

Tandem mirror theory workshop

International Nuclear Information System (INIS)

1981-05-01

The workshop was divided into three sections which were constituted according to subject matter: RF Heating, MHD Equilibrium and Stability, and Transport and Microstability. An overview from Livermore's point of view was given at the beginning of each session. Each session was assigned a secretary to take notes. These notes have been used in preparing this report on the workshop. The report includes the activities, conclusions, and recommendations of the workshop

Vaccine Adjuvant Incorporation Strategy Dictates Peptide Amphiphile Micelle Immunostimulatory Capacity.

Science.gov (United States)

Zhang, Rui; Kramer, Jake S; Smith, Josiah D; Allen, Brittany N; Leeper, Caitlin N; Li, Xiaolei; Morton, Logan D; Gallazzi, Fabio; Ulery, Bret D

2018-06-01

Current vaccine research has shifted from traditional vaccines (i.e., whole-killed or live-attenuated) to subunit vaccines (i.e., protein, peptide, or DNA) as the latter is much safer due to delivering only the bioactive components necessary to produce a desirable immune response. Unfortunately, subunit vaccines are very weak immunogens requiring delivery vehicles and the addition of immunostimulatory molecules termed adjuvants to convey protective immunity. An interesting type of delivery vehicle is peptide amphiphile micelles (PAMs), unique biomaterials where the vaccine is part of the nanomaterial itself. Due to the modularity of PAMs, they can be readily modified to deliver both vaccine antigens and adjuvants within a singular construct. Through the co-delivery of a model antigenic epitope (Ovalbumin 319-340 -OVA BT ) and a known molecular adjuvant (e.g., 2,3-dipalmitoyl-S-glyceryl cysteine-Pam 2 C), greater insight into the mechanisms by which PAMs can exert immunostimulatory effects was gained. It was found that specific combinations of antigen and adjuvant can significantly alter vaccine immunogenicity both in vitro and in vivo. These results inform fundamental design rules that can be leveraged to fabricate optimal PAM-based vaccine formulations for future disease-specific applications. Graphical Abstract.

International cooperation workshop. Regional workshop for CTBTO international cooperation: Africa

International Nuclear Information System (INIS)

1999-08-01

Pursuant to the 1999 programme of work, and following the International Cooperation Workshop held in Vienna, Austria, in 1998, the Provisional Technical Secretariat (PTS) of the Preparatory Commission for the CTBTO (Prep Com) held a regional Workshop for CTBTO International Cooperation in Cairo. The purpose of the workshop was to identify how and by what means the Africa region can promote international cooperation in CTBT verification related technologies, and how the region can benefit from and contribute to Prep Com activity. PTS staff briefed the 40 participants from 22 African States who attended the Workshop on general aspects, including costs, of the establishment and operation of the CTBT verification system, including its four monitoring technologies. Participants were informed on opportunities for local institutions in the establishment of monitoring stations and on possible support for national and regional data centres. National experts presented their research and development activities and reviewed existing experiences on bi/multi-lateral cooperation. The main points of the discussion focused on the need to engage governments to advance signature/ratification, and further training opportunities for African states

Adjuvant-enhanced CD4 T Cell Responses are Critical to Durable Vaccine Immunity.

Science.gov (United States)

Martins, Karen A O; Cooper, Christopher L; Stronsky, Sabrina M; Norris, Sarah L W; Kwilas, Steven A; Steffens, Jesse T; Benko, Jacqueline G; van Tongeren, Sean A; Bavari, Sina

2016-01-01

Protein-based vaccines offer a safer alternative to live-attenuated or inactivated vaccines but have limited immunogenicity. The identification of adjuvants that augment immunogenicity, specifically in a manner that is durable and antigen-specific, is therefore critical for advanced development. In this study, we use the filovirus virus-like particle (VLP) as a model protein-based vaccine in order to evaluate the impact of four candidate vaccine adjuvants on enhancing long term protection from Ebola virus challenge. Adjuvants tested include poly-ICLC (Hiltonol), MPLA, CpG 2395, and alhydrogel. We compared and contrasted antibody responses, neutralizing antibody responses, effector T cell responses, and T follicular helper (Tfh) cell frequencies with each adjuvant's impact on durable protection. We demonstrate that in this system, the most effective adjuvant elicits a Th1-skewed antibody response and strong CD4 T cell responses, including an increase in Tfh frequency. Using immune-deficient animals and adoptive transfer of serum and cells from vaccinated animals into naïve animals, we further demonstrate that serum and CD4 T cells play a critical role in conferring protection within effective vaccination regimens. These studies inform on the requirements of long term immune protection, which can potentially be used to guide screening of clinical-grade adjuvants for vaccine clinical development.

Influence of various forms of dialyzable leukocyte extracts on rat adjuvant arthritis

International Nuclear Information System (INIS)

Stancikova, Maria; Rovensky, Jozef; Blazickova, Stanislava; Pekarek, J.; Cech, Karel

1994-01-01

Adjuvant-induced arthritis in rats is a chronic inflammatory disease, widely as an animal model for rheumatoid arthritis. In our study the effect of various fractions of dialyzable leukocyte extract (DLE): DLE I-molecular weight below 10 kDa (commercial preparation), DLE II-molecular weight below 5 kDa (suppressor fraction), DLE III-molecular weight 5-10 kDa on rat adjuvant-induced arthritis was studied. The adjuvant arthritic (AA) rats were treated with DLE fractions i.p. in solutions containing an active substance isolated from 12.5 x 10 6 and 6.25 x 10 6 leukocytes from day 1 (adjuvant injected) through day 18, every second day (total 9 times). Various markers in inflammation, immune function and joint destruction were evaluated: hind paw volume, serum hyaluronic acid, serum albumin and biopterin in urine. All these markers showed a significant improvement after using fraction DLE II in comparison with AA controls. Fractions DLE I and DLE III influenced only some markers of inflammation and immune function. Our results demonstrated a therapeutical effect of fraction DLE II on rat adjuvant-induced arthritis. (author). 22 refs, 2 figs, 2 tabs

Environmental radioactive monitoring, evaluation and protection in luminous workshops of a factory

International Nuclear Information System (INIS)

Dai Hanbin; Xiang Ming; Tan Jianzu

2009-01-01

Fluorescent technique is often used to display instrumental indicator in the dark environment. Luminous workshops of a factory smear and depict the glassware by means of fluorescent power with adulterated radioactive matter. Because of adulterated radioactive matters such as 226 Ra, 40 K emit alpha-ray,beta-ray and gamma-ray, while they decay spontaneously, and high dose or cumulative radiation can damage human body in different degrees. Therefore, any radioactive damage to human body caused by over-safety dose should be prevented strictly during the working. To ensure health and safety of working staff in luminous workshop and the public, it is necessary to regularly have radioactive monitoring and evaluation to luminous workshop and its surrounding environment. Through the environment radioactive monitoring, the authors analyze its environmental radioactive level,and try to find out the possible problems so as to propose some protective measures for personal health. (authors)

PREFACE: 14th Micromechanics Europe Workshop (MME'03)

Science.gov (United States)

Wolffenbuttel, R. F.

2004-09-01

This special issue of the Journal of Micromechanics and Microengineering is devoted to the 14th Micromechanics Europe Workshop (MME'03), which was held at Delft University of Technology, The Netherlands on 2-4 November 2003. Papers have been selected from this workshop for presentation in this special issue. After a careful review by the MME'03 programme committee, 53 submissions were selected for poster presentation at the workshop in addition to 6 invited presentations. These covered the many aspects of our exciting field: technology, simulation, system design, fabrication and characterization in a wide range of applications. These contributions confirm a trend from technology-driven towards application-driven technological research. This trend has become possible because of the availability of mature fabrication technologies for micromechanical structures and is reflected by the presentations of some of the invited speakers. There were invited lectures about applications in the medical field, automotive and copiers, which provide evidence of the relevance of our work in society. Nevertheless, development of technologies rightfully remains a core activity of this workshop. This applies to both the introduction of new technologies, as was reflected by invited presentations on new trends in RIE and nanotechnology, and the addressing of manufacturing issues using available techniques, which will be demonstrated to be crucial in automotive applications. Out of these 59 papers 21 have been selected for presentation in this special issue. Since the scope of the workshop is somewhat wider than that of the journal, selection was based not only on the quality of the work, but also on suitability for presentation in the journal. Moreover, at the workshop, student presentation of research at an early stage was strongly encouraged, whereas publication of work in this journal requires a more advanced level. I would like to express my appreciation for the outstanding efforts

Network workshop

DEFF Research Database (Denmark)

Bruun, Jesper; Evans, Robert Harry

2014-01-01

This paper describes the background for, realisation of and author reflections on a network workshop held at ESERA2013. As a new research area in science education, networks offer a unique opportunity to visualise and find patterns and relationships in complicated social or academic network data....... These include student relations and interactions and epistemic and linguistic networks of words, concepts and actions. Network methodology has already found use in science education research. However, while networks hold the potential for new insights, they have not yet found wide use in the science education...... research community. With this workshop, participants were offered a way into network science based on authentic educational research data. The workshop was constructed as an inquiry lesson with emphasis on user autonomy. Learning activities had participants choose to work with one of two cases of networks...

Workshop report: US-China workshop on smart structures and smart systems

Science.gov (United States)

Tomizuka, Masayoshi

2006-03-01

A Joint U.S.-China workshop on the topic of Integrated Sensing Systems, Mechatronics and Smart Structures Technologies was held in Jinan, China in October 2005 to evaluate the current status of research and education in the topic areas in the United States and China, to identify critical and strategic research and educational issues of mutual interest, and to identify joint research projects and potential research teams for collaborative research activities. The workshop included a series of presentations by leading researchers and educators from the United States and China and group discussions on the workshop objectives.

Proceedings of Wireless Technology in the Electric Power Industry Workshop

International Nuclear Information System (INIS)

2001-01-01

A one-day workshop was conducted at EPRI Charlotte to identify technology issues related to wireless technology in nuclear power plants. The meeting concluded with a roundtable discussion to determine what projects could be conducted to address opportunities and gaps in this technology; the three projects recommended for further investigation were a risk analysis, development of a technology strategy, and development of guidelines for reliable implementation of wireless technologies. The Proceedings CD includes workshop presentations in PowerPoint format. The presentations cover the following topics: (1) Wireless Project at TXU: Integration of Voice, Data, and Video; (2) Radio Upgrade Project at Public Service Electric and Gas Company (PSE and G) of New Jersey; and (3) Operational Experience with Wireless Communication at Nuclear Plants

Meeting the public health challenge of protecting private wells: Proceedings and recommendations from an expert panel workshop

International Nuclear Information System (INIS)

Fox, Mary A.; Nachman, Keeve E.; Anderson, Breeana; Lam, Juleen

2016-01-01

Private wells serving fewer than 25 people are federally unregulated, and their users may be exposed to naturally occurring agents of concern such as arsenic and radionuclides, as well as anthropogenic contaminants. The Centers for Disease Control and Prevention's Clean Water for Health Program works to protect private wells and prevent adverse health outcomes for the roughly 15% of Americans who rely on them. To understand current and emerging challenges to the private drinking water supply, an interdisciplinary expert panel workshop on “Future and Emerging Issues for Private Wells” was organized to inform strategic planning for the Clean Water for Health Program. The panel assessed current conditions of ground water as a source for private wells, identified emerging threats, critical gaps in knowledge, and public health needs, and recommended strategies to guide future activities to ensure the safety of private drinking water wells. These strategies addressed topics of broad interest to the environmental public health community including: development of new methods to support citizen science; addressing contaminant mixtures; expanding capacity for well testing; evaluating treatment technologies; building an evidence base on best practices on well owner outreach and stewardship; and research and data needs. - Highlights: • About 43 million Americans use federally unregulated private wells for drinking water. • Private wells may be contaminated with naturally occurring and man-made chemicals. • Protecting well water requires an “infrastructure for stewardship”. • Recommendations to advance private well protection are offered.

Meeting the public health challenge of protecting private wells: Proceedings and recommendations from an expert panel workshop

Energy Technology Data Exchange (ETDEWEB)

Fox, Mary A., E-mail: mfox9@jhu.edu [Department of Health Policy and Management, Bloomberg School of Public Health, Johns Hopkins University, 624 North Broadway, Room 407, Baltimore, MD 21205 (United States); Risk Sciences and Public Policy Institute, Bloomberg School of Public Health, Johns Hopkins University, 624 North Broadway, Room 429, Baltimore, MD 21205 (United States); Nachman, Keeve E. [Department of Health Policy and Management, Bloomberg School of Public Health, Johns Hopkins University, 624 North Broadway, Room 407, Baltimore, MD 21205 (United States); Risk Sciences and Public Policy Institute, Bloomberg School of Public Health, Johns Hopkins University, 624 North Broadway, Room 429, Baltimore, MD 21205 (United States); Center for a Livable Future, Johns Hopkins University, 615 North Wolfe Street, Room W7010, Baltimore, MD 21205 (United States); Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, 615 North Wolfe Street, Baltimore, MD 21205 (United States); Anderson, Breeana [Risk Sciences and Public Policy Institute, Bloomberg School of Public Health, Johns Hopkins University, 624 North Broadway, Room 429, Baltimore, MD 21205 (United States); Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205 (United States); Lam, Juleen [Department of Health Policy and Management, Bloomberg School of Public Health, Johns Hopkins University, 624 North Broadway, Room 407, Baltimore, MD 21205 (United States); Risk Sciences and Public Policy Institute, Bloomberg School of Public Health, Johns Hopkins University, 624 North Broadway, Room 429, Baltimore, MD 21205 (United States); University of California at San Francisco, Department of Obstetrics, Gynecology & Reproductive Sciences, Mailstop 0132, 550 16th Street, 7th Floor, San Francisco, CA 94143 (United States); and others

2016-06-01

Private wells serving fewer than 25 people are federally unregulated, and their users may be exposed to naturally occurring agents of concern such as arsenic and radionuclides, as well as anthropogenic contaminants. The Centers for Disease Control and Prevention's Clean Water for Health Program works to protect private wells and prevent adverse health outcomes for the roughly 15% of Americans who rely on them. To understand current and emerging challenges to the private drinking water supply, an interdisciplinary expert panel workshop on “Future and Emerging Issues for Private Wells” was organized to inform strategic planning for the Clean Water for Health Program. The panel assessed current conditions of ground water as a source for private wells, identified emerging threats, critical gaps in knowledge, and public health needs, and recommended strategies to guide future activities to ensure the safety of private drinking water wells. These strategies addressed topics of broad interest to the environmental public health community including: development of new methods to support citizen science; addressing contaminant mixtures; expanding capacity for well testing; evaluating treatment technologies; building an evidence base on best practices on well owner outreach and stewardship; and research and data needs. - Highlights: • About 43 million Americans use federally unregulated private wells for drinking water. • Private wells may be contaminated with naturally occurring and man-made chemicals. • Protecting well water requires an “infrastructure for stewardship”. • Recommendations to advance private well protection are offered.

Public-policy responsibilities in a restructured electricity industry

Energy Technology Data Exchange (ETDEWEB)

Tonn, B.; Hirst, E.; Bauer, D.

1995-06-01

In this report, we identify and define the key public-policy values, objectives, and actions that the US electricity industry currently meets. We also discuss the opportunities for meeting these objectives in a restructured industry that relies primarily on market forces rather than on government mandates. And we discuss those functions that governments might undertake, presumably because they will not be fully met by a restructured industry on its own. These discussions are based on a variety of inputs. The most important inputs came from participants in an April 1995 workshop on Public-Policy Responsibilities and Electric Industry Restructuring: Shaping the Research Agenda. Other sources of information and insights include the reviews of a draft of this report by workshop participants and others and the rapidly growing literature on electric-industry restructuring and its implications. One of the major concerns about the future of the electricity industry is the fate of numerous social and environmental programs supported by today`s electric utilities. Many people worry that a market-driven industry may not meet the public-policy objectives that electric utilities have met in the past. Examples of potentially at-risk programs include demand-side management (DSM), renewable energy, low-income weatherization, and fuel diversity. Workshop participants represented electric utilities, public utility commissions (PUCs), state energy offices, public-interest groups, other energy providers, and the research community.

Adjuvants and the vaccine response to the DS-Cav1-stabilized fusion glycoprotein of respiratory syncytial virus.

Directory of Open Access Journals (Sweden)

Mallika Sastry

Full Text Available Appropriate adjuvant selection may be essential to optimize the potency and to tailor the immune response of subunit vaccines. To induce protective responses against respiratory syncytial virus (RSV-a highly prevalent childhood pathogen without a licensed vaccine-we previously engineered a pre-fusion-stabilized trimeric RSV F (pre-F "DS-Cav1" immunogen, which induced high titer RSV-neutralizing antibodies, in mice and non-human primates, when formulated with adjuvants Poly (I:C and Poly (IC:LC, respectively. To assess the impact of different adjuvants, here we formulated RSV F DS-Cav1 with multiple adjuvants and assessed immune responses. Very high RSV-neutralizing antibody responses (19,006 EC50 were observed in naïve mice immunized with 2 doses of DS-Cav1 adjuvanted with Sigma adjuvant system (SAS, an oil-in-water adjuvant, plus Carbopol; high responses (3658-7108 were observed with DS-Cav1 adjuvanted with Alum, SAS alone, Adjuplex, Poly (I:C and Poly (IC:LC; and moderate responses (1251-2129 were observed with DS-Cav1 adjuvanted with the TLR4 agonist MPLA, Alum plus MPLA or AddaVax. In contrast, DS-Cav1 without adjuvant induced low-level responses (6. A balanced IgG1 and IgG2a (Th2/Th1 immune response was elicited in most of the high to very high response groups (all but Alum and Adjuplex. We also tested the immune response induced by DS-Cav1 in elderly mice with pre-existing DS-Cav1 immunity; we observed that DS-Cav1 adjuvanted with SAS plus Carbopol boosted the response 2-3-fold, whereas DS-Cav1 adjuvanted with alum boosted the response 5-fold. Finally, we tested whether a mixture of ISA 71 VG and Carbopol would enhanced the antibody response in DS-Cav1 immunized calves. While pre-F-stabilized bovine RSV F induced very high titers in mice when adjuvanted with SAS plus Carbopol, the addition of Carbopol to ISA 71 VG did not enhance immune responses in calves. The vaccine response to pre-F-stabilized RSV F is augmented by adjuvant, but the

Gamma ray sterilization of delta inulin adjuvant particles (Advax™) makes minor, partly reversible structural changes without affecting adjuvant activity

Science.gov (United States)

Cooper, P. D.; Barclay, T. G.; Ginic-Markovic, M.; Petrovsky, N.

2014-01-01

We earlier identified a developmental series of seven isoforms/polymorphs of microparticulate inulin by comparing non-covalent bonding strengths. Their pharmaceutical utility lies in modulation of cellular immunity, exploited as vaccine adjuvants (Advax™) especially for delta inulin (DI). As such particles cannot be sterilized by filtration we explore the effect of 60Co gamma radiation (GR) on inulin isoforms, particularly DI. Its adjuvant activity and overt physical properties were unaffected by normal GR sterilizing doses (up to 25 kGy). Heating irradiated isoform suspensions near their critical dissolution temperature revealed increased solubility deduced to reflect a single lethal event in one component of a multi-component structure. Local oxidative effects of GR on DI were not found. The observed DI loss was almost halved by re-annealing at the critical temperature: surviving inulin chains apparently reassemble into smaller amounts of the original type of structure. Colorimetric tetrazolium assay revealed increases in reducing activity after GR of raw inulin powder, which yielded DI with normal physical properties but only 25% normal recovery yet 4× normal reducing ability, implying final retention of some GR-changed inulin chains. These findings suggest minimal inulin chain cleavage and confirm that GR may be a viable strategy for terminal sterilization of microparticulate inulin adjuvants. PMID:24342245

Benefit of Adjuvant Chemotherapy After Curative Resection of Lung Metastasis in Colorectal Cancer.

Science.gov (United States)

Park, Hyung Soon; Jung, Minkyu; Shin, Sang Joon; Heo, Su Jin; Kim, Chang Gon; Lee, Min Goo; Beom, Seung Hoon; Lee, Chang Young; Lee, Jin Gu; Kim, Dae Joon; Ahn, Joong Bae

2016-03-01

The survival benefit of adjuvant chemotherapy after colorectal cancer (CRC) lung metastasectomy is uncertain. We enrolled 221 CRC patients who underwent pulmonary metastasectomy between October 2002 and July 2013, including those with previous liver metastasis that had been curatively resected. Disease-free survival (DFS) and overall survival (OS) were calculated from the day of lung metastasectomy. Among all patients, 176 (79.6%) received adjuvant chemotherapy after lung metastasectomy. Median follow-up was 34.7 months from the time of lung metastasectomy [95% confidence interval (95% CI), 7.4-90.9 months]. Patients treated with adjuvant chemotherapy had longer DFS compared with surgery alone (median 32.7 vs 11.2 months respectively, P = 0.076). Multivariate analysis revealed previous liver metastasis, preoperative carcinoembryonic antigen ≥5 ng/mL, disease-free interval chemotherapy as independent risk factors for recurrence. Low-risk patients who had 0-1 risk factors received a significant survival benefit from adjuvant chemotherapy [hazard ratio (HR) 0.54; 95% CI 0.32-0.91, P = 0.020]; however, high-risk patients with ≥2 risk factors did not (HR 1.02; 95% CI 0.48-2.14, P = 0.964). Patients treated with adjuvant chemotherapy showed no OS benefit compared with patients who received surgery alone (median 89.6 vs 86.8 months respectively, P = 0.833). CRC patients received lung metastasectomy could have a DFS benefit from adjuvant chemotherapy, especially in low-risk patients. Larger, prospective studies are needed to evaluate the role of adjuvant chemotherapy after CRC lung metastasectomy.

Consumer and community involvement in health and medical research: evaluation by online survey of Australian training workshops for researchers.

Science.gov (United States)

McKenzie, Anne; Alpers, Kirsten; Heyworth, Jane; Phuong, Cindy; Hanley, Bec

2016-01-01

In Australia, since 2009, the Consumer and Community Involvement Program (formerly the Consumer and Community Participation Program) has developed and run workshops to help people working in health and medical research involve more consumers (patients) and community members (the public) in their research. In 2012, workshop attendees were invited to do an online survey to find out the effect, if any, that attending a workshop had on their awareness of and attitudes to consumer and community involvement. They were also asked about changes in their behaviour when it came to the involvement of consumers and the community in their work. The study found that, for people who answered the survey, more than double the number found consumer and community involvement very relevant after attending a workshop, compared with the number who thought that before attending one. Also, amongst those who answered the survey, 94 % thought that the workshop increased their understanding about involvement. Background There is limited evidence of the benefits of providing training workshops for researchers on how to involve consumers (patients) and the community (public) in health and medical research. Australian training workshops were evaluated to contribute to the evidence base. The key objective was to evaluate the impact of the workshops in increasing awareness of consumer and community involvement; changing attitudes to future implementation of involvement activities and influencing behaviour in the methods of involvement used. A secondary objective was to use a formal evaluation survey to build on the anecdotal feedback received from researchers about changes in awareness, attitudes and behaviours. Methods The study used a cross-sectional, online survey of researchers, students, clinicians, administrators and members of non-government organisations who attended Consumer and Community Involvement Program training workshops between 2009 and 2012 to ascertain changes to awareness

Innovative confinement concepts workshop

International Nuclear Information System (INIS)

Kirkpatrick, R.C.

1998-01-01

The Innovative Confinement Concepts Workshop occurred in California during the week preceding the Second Symposium on Current Trends in International Fusion Research. An informal report was made to the Second Symposium. A summary of the Workshop concluded that some very promising ideas were presented, that innovative concept development is a central element of the restructured US DOE. Fusion Energy Sciences program, and that the Workshop should promote real scientific progress in fusion

IPCC workshop on impacts of ocean acidification on marine biology and ecosystems. Workshop report

Energy Technology Data Exchange (ETDEWEB)

Field, C.B.; Barros, V.; Stocker, T.F.; Dahe, Q.; Mach, K.J.; Plattner, G.-K.; Mastrandrea, M.D.; Tignor, M.; Ebi, K.L.

2011-09-15

Understanding the effects of increasing atmospheric CO{sub 2} concentrations on ocean chemistry, commonly termed ocean acidification, as well as associated impacts on marine biology and ecosystems, is an important component of scientific knowledge about global change. The Fifth Assessment Report (AR5) of the Intergovernmental Panel on Climate Change (IPCC) will include comprehensive coverage of ocean acidification and its impacts, including potential feedbacks to the climate system. To support ongoing AR5 assessment efforts, Working Group II and Working Group I (WGII and WGI) of the IPCC held a joint Workshop on Impacts of Ocean Acidification on Marine Biology and Ecosystems in Okinawa, Japan, from 17 to 19 January 2011. The workshop convened experts from the scientific community, including WGII and WGI AR5 authors and review editors, to synthesise scientific understanding of changes in ocean chemistry due to increased CO{sub 2} and of impacts of this changing chemistry on marine organisms, ecosystems, and ecosystem services. This workshop report summarises the scientific content and perspectives presented and discussed during the workshop. It provides syntheses of these perspectives for the workshop's core topics: (i) the changing chemistry of the oceans, (ii) impacts of ocean acidification for individual organisms, and (iii) scaling up responses from individual organisms to ecosystems. It also presents summaries of workshop discussions of key cross-cutting themes, ranging from detection and attribution of ocean acidification and its impacts to understanding ocean acidification in the context of other stressors on marine systems. Additionally, the workshop report includes extended abstracts for keynote and poster presentations at the workshop. (Author)

Investing in trust: nuclear regulators and the public

International Nuclear Information System (INIS)

2001-01-01

The workshop was held in Paris on the 29. November - 1. December 2000. Its objective was well captured in the title: Investing in Trust, Nuclear Regulators and the Public. The general public is concerned with the risks involved in the use of nuclear power, and has a legitimate desire for reliable and impartial information. It is important to convince the people that the regulatory body works for them and for their safety and is not promoting the use of nuclear energy or any other interests. A necessary condition for being trustworthy is to be well known, efficient channels are needed, a good information must be transferred to two directions, information must be easily available to the public are some important points developed in this workshop. (N.C.)

The Affording Mars Workshop: Background and Recommendations

Science.gov (United States)

Thronson, Harley A.; Carberry, Christopher

2014-01-01

A human mission to Mars is the stated "ultimate" goal for NASA and is widely believed by the public to be the most compelling destination for America's space program. However, widely cited enormous costs - perhaps as much as a trillion dollars for a many-decade campaign - seem to be an impossible hurdle, although political and budget instability over many years may be equally challenging. More recently, a handful of increasingly detailed architectures for initial Mars missions have been developed by commercial companies that have estimated costs much less than widely believed and roughly comparable with previous major human space flight programs: the Apollo Program, the International Space Station, and the space shuttle. Several of these studies are listed in the bibliography to the workshop report. As a consequence of these new scenarios, beginning in spring, 2013 a multiinstitutional planning team began developing the content and invitee list for a winter workshop that would critically assess concepts, initiatives, technology priorities, and programmatic options to reduce significantly the costs of human exploration of Mars. The output of the workshop - findings and recommendations - would be presented in a number of forums and discussed with national leaders in human space flight. It would also be made available to potential international partners. This workshop was planned from the start to be the first in a series. Subsequent meetings, conferences, and symposia will concentrate on topics not able to be covered in December. In addition, to make progress in short meeting, a handful of ground rules were adopted by the planning team and agreed to by the participants. Perhaps the two most notable such ground rules were (1) the Space Launch System (SLS) and Orion would be available during the time frame considered by the participants and (2) the International Space Station (ISS) would remain the early linchpin in preparing for Mars exploration over the coming decade

Cyclic GMP-AMP displays mucosal adjuvant activity in mice.

Directory of Open Access Journals (Sweden)

Ivana Škrnjug

Full Text Available The recently discovered mammalian enzyme cyclic GMP-AMP synthase produces cyclic GMP-AMP (cGAMP after being activated by pathogen-derived cytosolic double stranded DNA. The product can stimulate STING-dependent interferon type I signaling. Here, we explore the efficacy of cGAMP as a mucosal adjuvant in mice. We show that cGAMP can enhance the adaptive immune response to the model antigen ovalbumin. It promotes antigen specific IgG and a balanced Th1/Th2 lymphocyte response in immunized mice. A characteristic of the cGAMP-induced immune response is the slightly reduced induction of interleukin-17 as a hallmark of Th17 activity--a distinct feature that is not observed with other cyclic di-nucleotide adjuvants. We further characterize the innate immune stimulation activity in vitro on murine bone marrow-derived dendritic cells and human dendritic cells. The observed results suggest the consideration of cGAMP as a candidate mucosal adjuvant for human vaccines.

Cyclic GMP-AMP displays mucosal adjuvant activity in mice.

Science.gov (United States)

Škrnjug, Ivana; Guzmán, Carlos Alberto; Rueckert, Christine; Ruecker, Christine

2014-01-01

The recently discovered mammalian enzyme cyclic GMP-AMP synthase produces cyclic GMP-AMP (cGAMP) after being activated by pathogen-derived cytosolic double stranded DNA. The product can stimulate STING-dependent interferon type I signaling. Here, we explore the efficacy of cGAMP as a mucosal adjuvant in mice. We show that cGAMP can enhance the adaptive immune response to the model antigen ovalbumin. It promotes antigen specific IgG and a balanced Th1/Th2 lymphocyte response in immunized mice. A characteristic of the cGAMP-induced immune response is the slightly reduced induction of interleukin-17 as a hallmark of Th17 activity--a distinct feature that is not observed with other cyclic di-nucleotide adjuvants. We further characterize the innate immune stimulation activity in vitro on murine bone marrow-derived dendritic cells and human dendritic cells. The observed results suggest the consideration of cGAMP as a candidate mucosal adjuvant for human vaccines.

Adjuvant chemotherapy compliance is not superior after thoracoscopic lobectomy

DEFF Research Database (Denmark)

Licht, Peter B; Schytte, Tine; Jakobsen, Erik

2014-01-01

BACKGROUND: It is generally assumed that patient compliance with adjuvant chemotherapy is superior after video-assisted thoracoscopic surgery compared with open lobectomy for non-small cell lung cancer (NSCLC). The level of evidence for this assumption, however, is limited to single-institution, ......BACKGROUND: It is generally assumed that patient compliance with adjuvant chemotherapy is superior after video-assisted thoracoscopic surgery compared with open lobectomy for non-small cell lung cancer (NSCLC). The level of evidence for this assumption, however, is limited to single...... adjuvant chemotherapy and 121 (38.7%) completed all four cycles. Ordinal logistic regression revealed that chemotherapy compliance (none, partial, and full chemotherapy) was significantly reduced by the patient's age (p....02). No significant difference between video-assisted thoracoscopic surgery and thoracotomy was seen regarding chemotherapy compliance (p=0.17), number of chemotherapy cycles (p=0.60), or time from surgery to chemotherapy (p = 0.41). CONCLUSIONS: Complete national data do not support the widespread assumption...

Workshop on Subcritical Neutron Production

International Nuclear Information System (INIS)

Walter Sadowski; Roald Sagdeev

2006-01-01

Executive Summary of the Workshop on Subcritical Neutron Production A workshop on Subcritical Neutron Production was sponsored by the East-West Center of the University of Maryland on October 11-13, 2004. The subject of the workshop was the application of subcritical neutrons to transmutation of actinides. The workshop was attended by members of the fission, accelerator and fusion communities. Papers on the state of development of neutron production by accelerators, fusion devices, and fission reactors were presented. Discussions were held on the potential of these technologies to solve the problems of spent nuclear waste storage and nuclear non-proliferation presented by current and future nuclear power reactors. A list of participants including their affiliation and their E-Mail addresses is attached. The workshop concluded that the technologies, presently available or under development, hold out the exciting possibility of improving the environmental quality and long term energy resources of nuclear power while strengthening proliferation resistance. The workshop participants agreed on the following statements. The workshop considered a number of technologies to deal with spent nuclear fuels and current actinide inventories. The conclusion was reached that substantial increase in nuclear power production will require that the issue of spent nuclear fuel be resolved. The Workshop concluded that 14 MeV fusion neutrons can be used to destroy nuclear reactor by-products, some of which would otherwise have to be stored for geologic periods of time. The production of 14 MeV neutrons is based on existing fusion technologies at different research institutions in several countries around the world. At the present time this technology is used to produce 14 MeV neutrons in JET. More development work will be required, however, to bring fusion technology to the level where it can be used for actinide burning on an industrial scale. The workshop concluded that the potential

Advanced Power Electronics Interfaces for Distributed Energy Workshop Summary: August 24, 2006, Sacramento, California

Energy Technology Data Exchange (ETDEWEB)

Treanton, B.; Palomo, J.; Kroposki, B.; Thomas, H.

2006-10-01

The Advanced Power Electronics Interfaces for Distributed Energy Workshop, sponsored by the California Energy Commission Public Interest Energy Research program and organized by the National Renewable Energy Laboratory, was held Aug. 24, 2006, in Sacramento, Calif. The workshop provided a forum for industry stakeholders to share their knowledge and experience about technologies, manufacturing approaches, markets, and issues in power electronics for a range of distributed energy resources. It focused on the development of advanced power electronic interfaces for distributed energy applications and included discussions of modular power electronics, component manufacturing, and power electronic applications.

IPHE Infrastructure Workshop Proceedings

Energy Technology Data Exchange (ETDEWEB)

None

2010-02-01

This proceedings contains information from the IPHE Infrastructure Workshop, a two-day interactive workshop held on February 25-26, 2010, to explore the market implementation needs for hydrogen fueling station development.

75 FR 37818 - Issues in the Design and Conduct of Clinical Trials for Antibacterial Drug Development; Public...

Science.gov (United States)

2010-06-30

... public workshop will help in developing topics for further discussion. Date and Time: The public workshop... Moser or Lori Benner, Center for Drug Evaluation and Research, Food and Drug Administration, Office of... of efficacy endpoints. Challenges in the conduct of clinical trials will be discussed, including good...

National Educators' Workshop: Update 2002 - Standard Experiments in Engineering, Materials Science, and Technology

Science.gov (United States)

Prior, Edwin J. (Compiler); Jacobs, James A. (Compiler); Chung, W. Richard (Compiler)

2003-01-01

This document contains a collection of experiments presented and demonstrated at the National Educators' Workshop: Update 2002 held in San Jose, California, October 13-16,2002. This publication provides experiments and demonstrations that can serve as a valuable guide to faculty who are interested in useful activities for their students. The material was the result of years of research aimed at better methods of teaching technical subjects. The experiments developed by faculty, scientists, and engineers throughout the United States and abroad add to the collection from past workshops. They include a blend of experiments on new materials and traditional materials.

75 FR 20009 - Development of NRC's Safety Culture Policy Statement: Cancellation of Public Workshops Scheduled...

Science.gov (United States)

2010-04-16

... included the development of the safety culture common terminology effort comprised of: (1) Development of a... alignment on the safety culture common terminology effort. The NRC held the first workshop on February 2-4... of individual industry groups, such as, [[Page 20010

Modern Vaccines/Adjuvants Formulation--Session 2 (Plenary II): May 15-17, 2013--Lausanne, Switzerland.

Science.gov (United States)

Collin, Nicolas

2013-09-01

On the 15-17th May 2013, the Fourth International Conference on Modern Vaccines/Adjuvants Formulation was organized in Lausanne, Switzerland, and gathered stakeholders from academics and from the industry to discuss several challenges, advances and promises in the field of vaccine adjuvants. Plenary session 2 of the meeting was composed of four different presentations covering: (1) the recent set-up of an adjuvant technology transfer and training platform in Switzerland, (2) the proposition to revisit existing paradigms of modern vaccinology, (3) the properties of polyethyleneimine as potential new vaccine adjuvant, and (4) the progresses in the design of HIV vaccine candidates able to induce broadly neutralizing antibodies.

The CLEAN Workshop Series: Promoting Effective Pedagogy for Teaching Undergraduate Climate Science

Science.gov (United States)

Kirk, K. B.; Bruckner, M. Z.; Manduca, C. A.; Buhr, S. M.

2012-12-01

To prepare students to understand a changing climate, it is imperative that we equip educators with the best possible tools and methods for reaching their audience. As part of the Climate Literacy and Energy Awareness Network (CLEAN) professional development efforts, two workshops for undergraduate faculty were held in 2012. These workshops used a variety of activities to help faculty learn about recent climate research, take part in demonstrations of successful activities for teaching climate topics, and collaborate to create new teaching materials. The workshops also facilitated professional networking among participants. Both workshops were held online, eliminating the need for travel, encouraging participants without travel funds to attend, and allowing international collaborations and presentations. To create an authentic experience, the workshop used several technologies such as the Blackboard Collaborate web conferencing platform, SERC's web-based collaboration tools and online discussion threads, and conference calls. The workshop Communicating Climate Science in the Classroom, held in April 2012, explored practices for communicating climate science and policy in the classroom and provided strategies to improve student understanding of this complex and sensitive topic. Workshop presentations featured public opinion research on Americans' perceptions of climate change, tactics for identifying and resolving student misconceptions, and methods to address various "backfire effects" that can result from attempts to correct misinformation. Demonstrations of teaching approaches included a role-playing simulation of emissions negotiations, Princeton's climate stabilization wedges game, and an activity that allows students to use scientific principles to tackle misinformation. The workshop Teaching Climate Complexity was held in May 2012. Teaching the complexities of climate science requires an understanding of many facets of the Earth system and a robust pedagogic

Practices and Experience in Stakeholder Involvement for Post-nuclear Emergency Management - Summary of the workshop

International Nuclear Information System (INIS)

Anon.

2011-01-01

One of the most important aspects of post-accident consequence management is the involvement of stakeholders: in the planning, preparation and execution as well as in sustaining efforts over the long term. Having recognised the significance of stakeholder participation in several International Nuclear Emergency Exercises (INEX), the NEA Committee on Radiation Protection and Public Health (CRPPH) decided to organise the Practices and Experience in Stakeholder Involvement for Post-nuclear Emergency Management Workshop to explore these issues. This summary highlights the key issues discussed during the workshop, which brought together 75 emergency management and communication specialists from 16 countries. In light of the accident at the Fukushima Daiichi nuclear power plant, the experience shared during this workshop will be central to further improving national emergency management arrangements

Assessment of side effects induced by injection of different adjuvant/antigen combinations in rabbits and mice

NARCIS (Netherlands)

Leenaars, P.P.A.M.; Koedam, M.A.; Wester, P.W.; Baumans, V.; Claassen, E.; Hendriksen, C.F.M.

1998-01-01

We evaluated the side effects induced by injection of Freund's adjuvant (FA) and alternative adjuvants combined with different antigens. Rabbits and mice were injected subcutaneously, intramuscularly (rabbits) and intraperitoneally (mice) with different adjuvants (FA, Specol, RIBI, TiterMax,

Adjuvant-enhanced CD4 T Cell Responses are Critical to Durable Vaccine Immunity

Directory of Open Access Journals (Sweden)

Karen A.O. Martins

2016-01-01

Full Text Available Protein-based vaccines offer a safer alternative to live-attenuated or inactivated vaccines but have limited immunogenicity. The identification of adjuvants that augment immunogenicity, specifically in a manner that is durable and antigen-specific, is therefore critical for advanced development. In this study, we use the filovirus virus-like particle (VLP as a model protein-based vaccine in order to evaluate the impact of four candidate vaccine adjuvants on enhancing long term protection from Ebola virus challenge. Adjuvants tested include poly-ICLC (Hiltonol, MPLA, CpG 2395, and alhydrogel. We compared and contrasted antibody responses, neutralizing antibody responses, effector T cell responses, and T follicular helper (Tfh cell frequencies with each adjuvant's impact on durable protection. We demonstrate that in this system, the most effective adjuvant elicits a Th1-skewed antibody response and strong CD4 T cell responses, including an increase in Tfh frequency. Using immune-deficient animals and adoptive transfer of serum and cells from vaccinated animals into naïve animals, we further demonstrate that serum and CD4 T cells play a critical role in conferring protection within effective vaccination regimens. These studies inform on the requirements of long term immune protection, which can potentially be used to guide screening of clinical-grade adjuvants for vaccine clinical development.

Evaluation of resistance training to improve muscular strength and body composition in cancer patients undergoing neoadjuvant and adjuvant therapy: a meta-analysis.

Science.gov (United States)

Padilha, Camila S; Marinello, Poliana Camila; Galvão, Daniel A; Newton, Robert U; Borges, Fernando H; Frajacomo, Fernando; Deminice, Rafael

2017-06-01

Muscle atrophy and strength decline are two of the most prominent characteristics in cancer patients undergoing cancer therapy, leading to decreased functional ability and reduced quality of life. Therefore, the aim is to systematically review research evidence of the effects of resistance exercise (RE) on lower-limb muscular strength, lean body mass (LBM), and body fat (BF) in cancer patients undertaking neoadjuvant or adjuvant therapy. This research was conducted using the following online database: Clinical Trial Register, Cochrane Trial Register, PubMed, SPORT Discus, and SciELO, from September 2014 until May 2015. We used the following keywords in various combinations with a systematic search: "Cancer therapy," "Wasting muscle," "Muscle loss," "Muscle function," "Neoadjuvant therapy," "Adjuvant thera-py," "Resistance Training," "Weight training," and "Exercise." After selection of 272 full-text articles, 14 publications were included in this meta-analysis. Resistance exercise (RE) during neoadjuvant or adjuvant therapy increased lower-limb muscular strength (mean: 26.22 kg, 95% CI [16.01, 36.43], heterogeneity: P = body mass (LBM) increased (mean 0.8 kg, 95% CI [0.7, 0.9], heterogeneity: P = 0.99, I 2  = 0%, P body fat (BF) (mean: -1.3 kg, 95% CI [-1.5, 1.1], heterogeneity: P = 0.93, I 2  = 0%, P cancer patients undergoing neoadjuvant and adjuvant therapy regardless of the kind of treatment. RE increases muscle strength, maintains LBM, and reduces BF in cancer patients undergoing adjuvant and neoadjuvant therapies. Cancer patients and survivors should consider undertaking RE as an effective countermeasure for treatment-related adverse effects to the musculoskeletal system.

Applications of ion beam analysis workshop. Workshop handbook

International Nuclear Information System (INIS)

1995-01-01

A workshop on applications of ion beam analysis was held at ANSTO, immediate prior to the IBMM-95 Conference in Canberra. It aims was to review developments and current status on use of ion beams for analysis, emphasizing the following aspects: fundamental ion beam research and secondary effects of ion beams; material sciences, geological, life sciences, environmental and industrial applications; computing codes for use in accelerator research; high energy heavy ion scattering and recoil; recent technological development using ion beams. The handbook contains the workshop's program, 29 abstracts and a list of participants

Summary and Recommendations from the National Institute of Allergy and Infectious Diseases (NIAID) Workshop "Gonorrhea Vaccines: the Way Forward".

Science.gov (United States)

Wetzler, Lee M; Feavers, Ian M; Gray-Owen, Scott D; Jerse, Ann E; Rice, Peter A; Deal, Carolyn D

2016-08-01

There is an urgent need for the development of an antigonococcal vaccine due to the increasing drug resistance found in this pathogen. The U.S. Centers for Disease Control (CDC) have identified multidrug-resistant gonococci (GC) as among 3 "urgent" hazard-level threats to the U.S. In light of this, on 29 to 30 June 2015, the National Institute for Allergy and Infectious Diseases (NIAID) sponsored a workshop entitled "Gonorrhea Vaccines: the Way Forward." The goal of the workshop was to gather leaders in the field to discuss several key questions on the current status of gonorrhea vaccine research and the path forward to a licensed gonorrhea vaccine. Representatives from academia, industry, U.S. Government agencies, and a state health department were in attendance. This review summarizes each of the 4 scientific sessions and a series of 4 breakout sessions that occurred during the one and a half days of the workshop. Topics raised as high priority for future development included (i) reinvigoration of basic research to understand gonococcal infection and immunity to allow intervention in processes essential for infection; (ii) clinical infection studies to establish parallels and distinctions between in vitro and animal infection models versus natural human genital and pharyngeal infection and to inform in silico modeling of vaccine impact; and (iii) development of an integrated pipeline for preclinical and early clinical evaluation and direct comparisons of potential vaccine antigens and adjuvants and routes of delivery. Copyright © 2016, American Society for Microbiology. All Rights Reserved.

Digital mapping techniques '06 - Workshop proceedings

Science.gov (United States)

Soller, David R.

2007-01-01

The Digital Mapping Techniques `06 (DMT`06) workshop was attended by more than 110 technical experts from 51 agencies, universities, and private companies, including representatives from 27 state geological surveys (see Appendix A of these Proceedings). This workshop was similar in nature to the previous nine meetings, which were held in Lawrence, Kansas (Soller, 1997), Champaign, Illinois (Soller, 1998), Madison, Wisconsin (Soller, 1999), Lexington, Kentucky (Soller, 2000), Tuscaloosa, Alabama (Soller, 2001), Salt Lake City, Utah (Soller, 2002), Millersville, Pennsylvania (Soller, 2003), Portland, Oregon (Soller, 2004), and Baton Rouge, Louisiana (Soller, 2005). This year?s meeting was hosted by the Ohio Geological Survey, from June 11-14, 2006, on the Ohio State University campus in Columbus, Ohio. As in the previous meetings, the objective was to foster informal discussion and exchange of technical information. It is with great pleasure that I note that the objective was successfully met, as attendees continued to share and exchange knowledge and information, and renew friendships and collegial work begun at past DMT workshops.Each DMT workshop has been coordinated by the Association of American State Geologists (AASG) and U.S. Geological Survey (USGS) Data Capture Working Group, the latter of which was formed in August 1996 to support the AASG and the USGS in their effort to build a National Geologic Map Database (see Soller, this volume, and http://ngmdb.usgs.gov/info/standards/datacapt/). The Working Group was formed because increased production efficiencies, standardization, and quality of digital map products were needed for the database - and for the State and Federal geological surveys - to provide more high-quality digital maps to the public.At the 2006 meeting, oral and poster presentations and special discussion sessions emphasized: 1) methods for creating and publishing map products (here, "publishing" includes Web-based release); 2) field data

Interferon alpha for the adjuvant treatment of cutaneous melanoma.

Science.gov (United States)

Mocellin, Simone; Lens, Marko B; Pasquali, Sandro; Pilati, Pierluigi; Chiarion Sileni, Vanna

2013-06-18

Interferon alpha is the only agent approved for the postoperative adjuvant treatment of high-risk cutaneous melanoma. However, the survival advantage associated with this treatment is unclear, especially in terms of overall survival. Thus, adjuvant interferon is not universally considered a gold standard treatment by all oncologists. To assess the disease-free survival and overall survival effects of interferon alpha as adjuvant treatment for people with high-risk cutaneous melanoma. We searched the following databases up to August 2012: the Cochrane Skin Group Specialised Register, CENTRAL in The Cochrane Library (2012, issue 8), MEDLINE (from 2005), EMBASE (from 2010), AMED (from 1985), and LILACS (from 1982). We also searched trials databases in 2011, and proceedings of the ASCO annual meeting from 2000 to 2011. We checked the reference lists of selected articles for further references to relevant trials. We included only randomised controlled trials (RCTs) comparing interferon alpha to observation (or any other treatment) for the postoperative (adjuvant) treatment of patients with high-risk skin melanoma, that is, people with regional lymph node metastasis (American Joint Committee on Cancer (AJCC) TNM (tumour, lymph node, metastasis) stage III) undergoing radical lymph node dissection, or people without nodal disease but with primary tumour thickness greater than 1 mm (AJCC TNM stage II). Two authors extracted data, and a third author independently verified the extracted data. The main outcome measure was the hazard ratio (HR), which is the ratio of the risk of the event occurring in the treatment arm (adjuvant interferon) compared to the control arm (no adjuvant interferon). The survival data were either entered directly into Review Manager (RevMan) or extrapolated from Kaplan-Meier plots and then entered into RevMan. Based on the presence of between-study heterogeneity, we applied a fixed-effect or random-effects model for calculating the pooled estimates

Autoimmune/inflammatory syndrome induced by adjuvants (Shoenfeld's syndrome) - An update.

Science.gov (United States)

Watad, A; Quaresma, M; Brown, S; Cohen Tervaert, J W; Rodríguez-Pint, I; Cervera, R; Perricone, C; Shoenfeld, Y

2017-06-01

Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) has been widely described in many studies conducted thus far. The syndrome incorporates five immune-mediated conditions, all associated with previous exposure to various agents such as vaccines, silicone implants and several others. The emergence of ASIA syndrome is associated with individual genetic predisposition, for instance those carrying HLA-DRB1*01 or HLA-DRB4 and results from exposure to external or endogenous factors triggering autoimmunity. Such factors have been demonstrated as able to induce autoimmunity in both animal models and humans via a variety of proposed mechanisms. In recent years, physicians have become more aware of the existence of ASIA syndrome and the relationship between adjuvants exposure and autoimmunity and more cases are being reported. Accordingly, we have created a registry that includes at present more than 300 ASIA syndrome cases that have been reported by different physicians worldwide, describing various autoimmune conditions induced by diverse adjuvants. In this review, we have summarized the updated literature on ASIA syndrome and the knowledge accumulated since 2013 in order to elucidate the association between the exposure to various adjuvant agents and its possible clinical manifestations. Furthermore, we especially referred to the relationship between ASIA syndrome and systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS).

Accounting for adjuvant-induced artifacts in the characterization of vaccine formulations by polyacrylamide gel electrophoresis.

Science.gov (United States)

Jakob, Virginie; Brunner, Livia; Barnier-Quer, Christophe; Blust, Molly; Collin, Nicolas; Carter, Lauren; Carter, Darrick; Rausch, Kelly M; Fox, Christopher B

2017-04-01

Several vaccine adjuvants comprise complex nano- or micro-particle formulations, such as oil-in-water emulsions. In order to characterize interactions and compatibility of oil-in-water emulsion adjuvants with protein antigens in vaccines, effective protein characterization methods that can accommodate potential interference from high concentrations of lipid-based particles are needed. Sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) is a standard protein characterization technique which is affected by the presence of adjuvants such as oil-in-water emulsions. In this article, we investigate variations in SDS-PAGE methods that result in a reduction of adjuvant-induced staining artifacts. We have investigated whether the SDS method or the adjuvant composition were the reason for these artifacts and succeeded in reducing the artifacts with a modified sample preparation and different staining procedures. The best results were obtained by using gold staining or silver staining instead of a Coomassie Blue staining procedure. Moreover, the replacement of the dilution buffer (20% SDS to disrupt emulsion) by alternative detergents such as Tween® 80 and Triton® X-100 removed adjuvant-induced streaking artifacts at the top of the gel. These methods may be useful for improving characterization approaches of antigen-adjuvant mixtures by SDS-PAGE.

Summer 1994 Computational Science Workshop. Final report

Energy Technology Data Exchange (ETDEWEB)

NONE

1994-12-31

This report documents the work performed by the University of New Mexico Principal Investigators and Research Assistants while hosting the highly successful Summer 1994 Computational Sciences Workshop in Albuquerque on August 6--11, 1994. Included in this report is a final budget for the workshop, along with a summary of the participants` evaluation of the workshop. The workshop proceeding have been delivered under separate cover. In order to assist in the organization of future workshops, we have also included in this report detailed documentation of the pre- and post-workshop activities associated with this contract. Specifically, we have included a section that documents the advertising performed, along with the manner in which applications were handled. A complete list of the workshop participants in this section. Sample letters that were generated while dealing with various commercial entities and departments at the University are also included in a section dealing with workshop logistics. Finally, we have included a section in this report that deals with suggestions for future workshops.

Vulcano Workshop 2016

CERN Document Server

Mannocchi, G.; Morselli, A.; Trinchero, G.

2016-01-01

We announce the XVI Vulcano Workshop, which will be held from May 22nd to May 28th, 2016 in the Vulcano Island (Sicily, Italy). As in the past editions, the workshop will aim to gather people from High Energy Astrophysics and Particle Physics to discuss the most recent highlights in these fields. The workshop will cover the following topics: Astrophysics/Cosmology, Astrophysics/Gravity, Dark Matter, Particle Physics, Cosmic Rays, Gamma/Neutrino Astronomy, Neutrinos and Future Prospects. The scientific program will include several 30-minute review talks, to introduce the current problems, and 20-minute talks, giving new experimental and theoretical results. The participation is by invitation and limited to 80 people.

CEBAF/SURA 1985 Summer Workshop

International Nuclear Information System (INIS)

Crannel, H.

1985-12-01

The 1985 Summer Workshop began a new phase of planning for the experimental program at CEBAF. One goal of the Workshop was to define and describe options for equipping the CEBAF and stations with experimental equipment. Starting with an initial list of options which grew out of discussions during the Winter of 1984 and the Spring of 1985, the five working groups met during the Workshop and developed their final reports, included in these proceedings. The program of the Workshop consisted of invited talks on both theoretical and experimental topics, and working group meetings. The five working groups, include: Magnetic Spectrometers; Large Acceptance Detectors and Low Intensity Beams; Internal Targets; Positrons; Theory. These proceedings begin with an overview of CEBAF, and a report on progress made by the Magnetic Spectrometer and Internal Target Working Groups prior to the Workshop. The next part contains the invited talks, presented in the order which they were given during the week. The final reports of the five working groups follow this, and the proceedings conclude with papers contributed to the Workshop

N Reactor Lessons Learned workshop

International Nuclear Information System (INIS)

Heaberlin, S.W.

1993-07-01

This report describes a workshop designed to introduce participants to a process, or model, for adapting LWR Safety Standards and Analysis Methods for use on rector designs significantly different than LWR. The focus of the workshop is on the ''Lessons Learned'' from the multi-year experience in the operation of N Reactor and the efforts to adapt the safety standards developed for commercial light water reactors to a graphite moderated, water cooled, channel type reactor. It must be recognized that the objective of the workshop is to introduce the participants to the operation of a non-LWR in a LWR regulatory world. The total scope of this topic would take weeks to provide a through overview. The objective of this workshop is to provide an introduction and hopefully establish a means to develop a longer term dialogue for technical exchange. This report provides outline of the workshop, a proposed schedule of the workshop, and a description of the tasks will be required to achieve successful completion of the project

Adjuvant radiotherapy for stage I endometrial cancer.

Science.gov (United States)

Kong, A; Johnson, N; Cornes, P; Simera, I; Collingwood, M; Williams, C; Kitchener, H

2007-04-18

The role of adjuvant radiotherapy (both pelvic external beam radiotherapy and vaginal intracavity brachytherapy) in stage I endometrial cancer following total abdominal hysterectomy and bilateral salpingo-oophorectomy (TAH and BSO) remains unclear. To assess the efficacy of adjuvant radiotherapy following surgery for stage I endometrial cancer. The Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, CancerLit, Physician Data Query (PDQ) of National Cancer Institute. Handsearching was also carried out where appropriate. Randomised controlled trials (RCTs) which compared adjuvant radiotherapy versus no radiotherapy following surgery for patients with stage I endometrial cancer were included. Quality of the studies was assessed and data collected using a predefined data collection form. The primary endpoint was overall survival. Secondary endpoints were locoregional recurrence, distant recurrence and endometrial cancer death. Data on quality of life (QOL) and morbidity were also collected. A meta-analysis on included trials was performed using the Cochrane Collaboration Review Manager Software 4.2. The meta-analysis was performed on four trials (1770 patients). The addition of pelvic external beam radiotherapy to surgery reduced locoregional recurrence, a relative risk (RR) of 0.28 (95% confidence interval (CI) 0.17 to 0.44, p ASTEC; Lukka) are awaited. External beam radiotherapy carries a risk of toxicity and should be avoided in stage 1 endometrial cancer patients with no high risk factors.

SUPPORT FOR HU CFRT SUMMER HIGH SCHOOL FUSION WORKSHOP

International Nuclear Information System (INIS)

Punjabi, Alkesh

2010-01-01

researchers in the HU CFRT mentor the students during summers. Mentors spend a considerable amount of time and efforts in training, teaching, guiding and supervising research projects. The HU CFRT has so far conducted nine workshops during the summers of 1996-2000 and 2002-2005. The first workshop was conducted in summer 1996. Students for the workshop are chosen from a national pool of exceptionally talented high school rising seniors/juniors. To our knowledge, most of these students have gone on to prestigious universities such as Duke University, John Hopkins University, CalTech, UCLA, Hampton University, etc. after completing their high school. For instance, Tiffany Fisher, participant of the 1996 summer workshop completed her BS in Mathematics at Hampton University in May 2001. She then went on to Wake Forest University at Winston-Salem, North Carolina to pursue graduate studies. Anshul Haldipur, participant of the 1999 summer workshop, began his undergraduate studies at Duke University in 2000. Christina Nguyen and Ilissa Martinez, participants of the 2000 summer workshop, are pursuing their undergraduate degrees at the UCLA and Florida State University respectively. The organizing committee of the APS DPP annual meeting invited Dr. Punjabi to deliver an invited talk on training the next generation of fusion scientists and engineers at the 2005 APS DPP meeting in Denver, CO. The organizing committee distributed a special flier with the Bulletin to highlight this invited talk and another talk on education as well the expo. This has given wide publicity and recognition to our workshops and Hampton University. Prof. Punjabi's talk: 'LI2 2: Training the next generation of fusion scientists and engineers: summer high school fusion science workshop, Bull. Amer. Phys. Soc. 50, 221 (2005)' was very well-received. He talked about HU education and outreach initiative and the HU CFRT Summer High School Workshop. The audience had a considerable number of questions about our

Interactive Forms of Open Scientific and Educational Workshop

OpenAIRE

Naumova Galina Alekseevna; Borisanova Yana Andreevna; Arzamastseva Anna Yuryevna

2014-01-01

The article discusses the innovative chain of the Russian economy which consists of three stages: “Idea” (academic science), “Technology” (applied science), and “Production”. The authors describe the innovative system of Russia in terms of infrastructure devices, the functioning of the financial system and human resources. Special attention is paid to the problem of staff training for the innovation economy in Russia. The authors propose the use of scientific and educational public workshop a...

NRSE technologies and trends workshop

Energy Technology Data Exchange (ETDEWEB)

Seo, W S; Lee, T K; Jo, D K; Jeong, M W; Kim, H W; Yoon, K S [Korea Inst. of Energy Research, Taejon (Korea, Republic of)

1995-12-01

The object of this workshop are to exchange scientific knowledge of exports, to collect the information on the current research trends and policies through the presentations of NRSE technologies and their case studies both at home and aboard. Another objects are to promote the international cooperation in the field of new and renewable energy research, and to provide a chance for taking new technologies to industries for the practical use or for commercialization. Research and development trends in NRSE technologies by major research institutions are investigated to make a comparative review as a reference for the future NRSE projects. Coupled with the government`s`s NRSE development policy, it has played an important role to make an increased public relations with the general public with respect to the development necessity of NRSE. The forum was very useful for an increased exchange of views on NRSE technologies of mutual interest between NRSE lectures and participants. (author)

Adjuvant chemotherapy for gastric cancer: Current evidence and future challenges

OpenAIRE

Miceli, Rosalba; Tomasello, Gianluca; Bregni, Giacomo; Di Bartolomeo, Maria; Pietrantonio, Filippo

2014-01-01

Gastric cancer still represents one of the major causes of cancer mortality worldwide. Patients survival is mainly related to stage, with a high proportion of patients with metastatic disease at presentation. Thus, the cure rate largely depend upon surgical resection. Despite the additional, albeit small, benefit of adjuvant chemotherapy has been clearly demonstrated, no general consensus has been reached on the best treatment option. Moreover, the narrow therapeutic index of adjuvant chemoth...

Adjuvant effect in aquaculture fish of cell-wall glycolipids isolated from acid-fast bacteria.

Science.gov (United States)

Matsumoto, Megumi; Araki, Kyosuke; Nishimura, Sayaka; Kuriyama, Hideki; Nakanishi, Teruyuki; Shiozaki, Kazuhiro; Takeuchi, Yutaka; Yamamoto, Atsushi

2018-08-01

Mycobacteriosis and nocardiosis in cultured fish caused by infections with acid-fast bacteria, are responsible for large economic losses globally. In this study, we suggest a novel adjuvant using glycolipids that activates host immune systems. The immune response to glycolipids stimulation was investigated using ginbuna crucian carp. Ginbuna vaccinated with FKC (formalin-killed cells) + glycolipids isolated from Mycobacterium sp., upregulated inflammatory- and Th1-related cytokines, and a DTH (delayed-type hypersensitivity) response was confirmed only in ginbuna vaccinated with FKC + glycolipids. These observations suggest that glycolipids activated host innate and cell-mediated immunity. Subsequently, we evaluated the adjuvant effect of glycolipids against amberjack nocardiosis. In a challenge test, a higher survival rate was observed in amberjack vaccinated with FKC + glycolipids emulsified with conventional oil adjuvant than in fish vaccinated with FKC + oil adjuvant without glycolipids. Therefore, glycolipids potentially could be used as a practical, economical and safe adjuvant for aquaculture fish. Copyright © 2018. Published by Elsevier Ltd.

Teaching Environmental Geology in the 21St Century: A Workshop Report

Science.gov (United States)

Mogk, D. W.; Wiese, K.; Castendyk, D.; McDaris, J. R.

2012-12-01

Environmental Geology encompasses a range of topics that include geohazards, natural resources, issues such as climate change, human health, and environmental policy. Instruction in Environmental Geology provides students the opportunity to address the grand challenges facing humanity regarding how to live sustainably and responsibly on Earth. Instruction in Environmental Geology ranges from dedicated introductory courses, instructional modules in upper division Earth Science "core" classes, to courses in related disciplines such as environmental science, ecology, and the social and political sciences. To explore the opportunities of teaching Environmental Geology in all these contexts, the On the Cutting Edge program convened a workshop in June 2012 to bring together instructors representing a diversity of instructional settings. The goals of the workshop were to: 1) Share innovative teaching methods, approaches, and activities for teaching Environmental Geology and share ideas on how to teach in various contexts. 2) Examine where and how environmental geology topics are taught in the geoscience curriculum from introductory courses for non-majors to "core" geoscience courses for majors. 3) Consider the ways that Environmental Geology courses and topical materials can contribute to public science literacy, particularly how to make personal and societal decisions about the range of issues facing humanity and to live responsibly and sustainably on this planet. 4) Develop a list of best practices for integrating emerging environmental issues, recent natural disasters, and issues related to natural resources into course work and identifying how scientific data and research outcomes can inform public discourse on topical issues. 5) Develop strategies to reach under-represented groups and expand the diversity of students who enroll in our courses. 6) Identify topics of high interest and need for future development as teaching modules and courses. The workshop program

The role of adjuvant radiotherapy in the treatment of resectable desmoid tumors

International Nuclear Information System (INIS)

Goy, Barry W.; Lee, Steve P.; Eilber, Frederick; Dorey, Fred; Eckardt, Jeffrey; Fu, Y.-S.; Juillard, Guy J.F.; Selch, Michael T.

1996-01-01

Purpose/Objective: Desmoid tumors have a high propensity for local recurrence with surgical resection. There are many reports describing good responses of desmoid tumors to irradiation, but none have clearly proven the indications for adjuvant radiotherapy in treating resectable desmoid tumors. Materials and Methods: A retrospective analysis was performed on 61 patients with resectable desmoid tumors who were treated at our institution from 1965 to 1992. Fifty-six patients had unifocal disease, of which 34 had positive surgical margins. Forty-five were treated with surgery alone, while 11 received surgery plus adjuvant radiotherapy. Median follow-up was 6 years. Local control was measured from the last day of treatment, and all cases were reviewed by our Department of Pathology. Results: Univariate analysis of 56 patients with unifocal disease revealed that female gender (p=0.025) and positive margins (p=0.032) predicted for local recurrence. Multivariate analysis revealed that only positive margins (p=0.003) independently predicted for local recurrence. Only 3 of 22 patients had local recurrences with clear margins, with a 6 year actuarial local control of 85%. We analyzed 34 patients with positive margins by univariate analysis, and only adjuvant radiotherapy predicted for improved local control (p=0.031). Multivariate analysis of these 34 patients revealed that adjuvant radiotherapy independently predicted for local control (p=0.012), and patients with recurrent disease had a slightly higher risk of local recurrence (p=0.083). The 6 year actuarial local control determined by Kaplan-Meier for patients with unifocal disease and positive margins was 32%(±12%) with surgery alone, and 78%(±14%) with surgery plus adjuvant radiotherapy (p=0.019). None of the patients who received radiotherapy for unifocal disease developed serious complications, or a secondary malignancy. Conclusions: Adjuvant radiotherapy is indicated in the treatment of patients with resectable

Report of the Orientation Workshop

DEFF Research Database (Denmark)

Nunez, Heilyn Camacho; Buus, Lillian; Ogange, Betty

2014-01-01

This Orientation Workshops is part of MAAGART project. The workshop is divided in three parts: 1) pre-Orientation Workshop stage, 2) Face-to-Face stage and 3) post-Orientation stage. Pre and post stages will be developed online. All the activities will take place in a virtual learning environment...... created for this purpose. Participants will receive all the information about how to access the virtual learning environment (Moodle) prior to the pre-orientation workshop. In this report we cover only the two first stages. Jørgen Bang, as a part of the Community of Practice activity, will be facilitating...

Healthy Young Minds: The Effects of a 1-hour Classroom Workshop on Mental Illness Stigma in High School Students

Science.gov (United States)

Ke, Sally; Lai, Joshua; Sun, Terri; Yang, Michael M. H.; Wang, Jay Ching Chieh; Austin, Jehannine

2014-01-01

Background This study aimed to test the effects of a one-hour classroom-based workshop, led by medical students, on mental illness stigma amongst secondary school students. Method Students (aged 14–17) from three public secondary schools in British Columbia participated in the workshop. A questionnaire measuring stigma (including stereotype endorsement and desire for social distance) was administered immediately before (T1), immediately after (T2), and 1-month post-workshop (T3). Results A total of 279 students met the study inclusion criteria. Total scores on the stigma scale decreased by 23% between T1 and T2 (pstigma reduction compared to pre-intervention (preduced through a one-hour easily implementable and cost-effective classroom-based workshop led by medical students. PMID:25017811

Proceeding of the public safety around dams conference

Energy Technology Data Exchange (ETDEWEB)

NONE

2011-07-01

The Canadian Dam Association hosted the Public Safety Around Dams workshop in which presentations were given in the morning to describe the different measures and methods implemented by the Ontario Ministry of Natural Resources, Ontario Power Generation and others to improve safety around dams. In the afternoon, the participants toured the Auburn and Lakefield dams and facilities to view the infrastructures and equipment. A roundtable discussion concluded the day. Following this workshop, a Public Safety Around Dams group was created on the social network site, LinkedIn. This conference featured 6 presentations, 3 of which have been catalogued separately for inclusion in this database.

Reactor experiments, workshops, and human resource development education simulating the Great East Japan Earthquake

International Nuclear Information System (INIS)

Horiguchi, Tetsuo; Yamamoto, Tomosada

2012-01-01

Kinki University Atomic Energy Research Institute has been implementing a social education program such as reactor experiments and training sessions for junior and senior high school teachers since 1987, and in recent years, it has been implementing an education program for common citizens. However, the Great East Japan Earthquake has made it necessary to consider not only the dissemination of accurate knowledge, but also responding to the anxiety on nuclear power. This paper explains the contents of the social contribution activities and workshops conducted at Kinki University Atomic Energy Research Institute, after the Great East Japan Earthquake and the Fukushima Daiichi Nuclear Power Station accident. As the activities that are carried out in addition to training sessions, it introduces the implementation state of telephone consultation about nuclear power, and earthquake reconstruction assistance advisory at Kawamata Town, Date-gun, Fukushima Prefecture. As workshop support, it reports human resource development education in the nuclear field at the university, activities at the workshops for junior/senior high school teachers and general public, and questionnaire survey at the time of the workshops. (A.O.)

Forging a potent vaccine adjuvant: CpG ODN/cationic peptide nanorings.

Science.gov (United States)

Gungor, Bilgi; Yagci, Fuat Cem; Gursel, Ihsan; Gursel, Mayda

Type I interferon inducers may potentially be engineered to function as antiviral and anticancer agents, or alternatively, vaccine adjuvants, all of which may have clinical applications. We recently described a simple strategy to convert a Toll-like receptor 9 (TLR9) agonist devoid of interferon α (IFNα) stimulating activity into a robust Type I interferon inducer with potent vaccine adjuvant activity.

Natural and synthetic saponin adjuvant QS-21 for vaccines against cancer

Science.gov (United States)

Ragupathi, Govind; Gardner, Jeffrey R; Livingston, Philip O; Gin, David Y

2013-01-01

One of the most widely used and potent immunological adjuvants is a mixture of soluble triterpene glycosides purified from the soap bark tree (Quillaja saponaria). Despite challenges in production, quality control, stability and toxicity, the QS-21 fraction from this extract has exhibited exceptional adjuvant properties for a range of antigens. It possesses an ability to augment clinically significant antibody and T-cell responses to vaccine antigens against a variety of infectious diseases, degenerative disorders and cancers. The recent synthesis of active molecules of QS-21 has provided a robust method to produce this leading vaccine adjuvant in high purity as well as to produce novel synthetic QS-21 congeners designed to induce increased immune responsiveness and decreased toxicity. PMID:21506644

Genetic Mechanisms of Antibiotic Resistance and the Role of Antibiotic Adjuvants.

Science.gov (United States)

Pontes, Daniela Santos; de Araujo, Rodrigo Santos Aquino; Dantas, Natalina; Scotti, Luciana; Scotti, Marcus Tullius; de Moura, Ricardo Olimpio; Mendonca-Junior, Francisco Jaime Bezerra

2018-01-01

The ever increasing number of multidrug-resistant microorganism pathogens has become a great and global public health threat. Antibiotic mechanisms of action and the opposing mechanisms of resistance are intimately associated, but comprehension of the biochemical and molecular functions of such drugs is not a simple exercise. Both the environment, and genetic settings contribute to alterations in phenotypic resistance (natural bacterial evolution), and make it difficult to control the emergence and impacts of antibiotic resistance. Under such circumstances, comprehension of how bacteria develop and/or acquire antibiotic resistance genes (ARG) has a critical role in developing propositions to fight against these superbugs, and to search for new drugs. In this review, we present and discuss both general information and examples of common genetic and molecular mechanisms related to antibiotic resistance, as well as how the expression and interactions of ARGs are important to drug resistance. At the same time, we focus on the recent achievements in the search for antibiotic adjuvants, which help combat antibiotic resistance through deactivation of bacterial mechanisms of action such as β-lactamases. Recent advances involving the use of anti-resistance drugs such as: efflux pump inhibitors; anti-virulence drugs; drugs against quorum sensing; and against type II/III secretion systems are revealed. Such antibiotic adjuvants (as explored herein) collaborate against the problems of antibiotic resistance, and may restore or prolong the therapeutic activity of known antibiotics. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Combined-modality treatment in advanced oral squamous cell carcinoma. Primary surgery followed by adjuvant concomitant radiochemotherapy

International Nuclear Information System (INIS)

Kreppel, Matthias; Dreiseidler, Timo; Zoeller, Joachim E.; Scheer, Martin; Drebber, Uta; Eich, Hans-Theodor; Mueller, Rolf-Peter

2011-01-01

The efficacy of adjuvant radiochemotherapy (RCT) in patients with advanced stage head and neck carcinoma has been proven in prospective randomized trials. However, these trials focused on different head and neck sites. Specific analyses for treatment effects in squamous cell carcinoma of the oral cavity (OSCC) are missing. We evaluated our experiences with adjuvant concomitant RCT in advanced OSCC to compare the results with other treatment schemes using adjuvant RCT. A total of 183 patients with OSCC of UICC stages II-IVb were reviewed retrospectively. All patients were treated with radical surgery followed by adjuvant, conventional fractionated concomitant RCT using carboplatin. Overall survival was plotted by Kaplan-Meier analysis. Prognostic factors were identified through univariate and multivariate analysis. Univariate analysis showed a significant impact of T, N, and UICC stage, histopathologic grading, surgical margins, extracapsular spread (ECS), and lymphangiosis carcinomatosa on overall survival (Table 3). Patients with stage IVa had a higher 5-year overall survival rate (42.8%) than patients with stage IVb (25.0%) (Figure 1). The differences were significant in multivariate analysis (p = 0.033) (Table 4). Adjuvant concomitant RCT is an effective treatment in patients with advanced stage OSCC. However, it remains unclear, which patients should be treated with adjuvant RCT. For patients with stage IVb, adjuvant RCT yields poor results. Prospective randomized trials are needed to confirm which patients should be treated with adjuvant RCT. (orig.)

International workshop on knowledge management in scientific organizations, KMSO 2009, Damascus (SY), 9-11 March 2009

International Nuclear Information System (INIS)

2009-01-01

This publication includes the papers presented at the International workshop on knowledge management in scientific organizations which held in Damascus 9-11 March 2009. KM processes and technologies are main topics of the workshop with keynote speeches and exercises covering: Knowledge Generation, Knowledge Preservation, Knowledge Distribution, Knowledge Utilization and KM technologies which cover Information and Communication Technology, Internet, Intranet and Extranet, Data Mining and Warehousing, Knowledge bases and information repositories, Information retrieval, Intelligent agents and expert systems, Groupware and collaborative systems

Nomogram for Predicting the Benefit of Adjuvant Chemoradiotherapy for Resected Gallbladder Cancer

Science.gov (United States)

Wang, Samuel J.; Lemieux, Andrew; Kalpathy-Cramer, Jayashree; Ord, Celine B.; Walker, Gary V.; Fuller, C. David; Kim, Jong-Sung; Thomas, Charles R.

2011-01-01

Purpose Although adjuvant chemoradiotherapy for resected gallbladder cancer may improve survival for some patients, identifying which patients will benefit remains challenging because of the rarity of this disease. The specific aim of this study was to create a decision aid to help make individualized estimates of the potential survival benefit of adjuvant chemoradiotherapy for patients with resected gallbladder cancer. Methods Patients with resected gallbladder cancer were selected from the Surveillance, Epidemiology, and End Results (SEER) –Medicare database who were diagnosed between 1995 and 2005. Covariates included age, race, sex, stage, and receipt of adjuvant chemotherapy or chemoradiotherapy (CRT). Propensity score weighting was used to balance covariates between treated and untreated groups. Several types of multivariate survival regression models were constructed and compared, including Cox proportional hazards, Weibull, exponential, log-logistic, and lognormal models. Model performance was compared using the Akaike information criterion. The primary end point was overall survival with or without adjuvant chemotherapy or CRT. Results A total of 1,137 patients met the inclusion criteria for the study. The lognormal survival model showed the best performance. A Web browser–based nomogram was built from this model to make individualized estimates of survival. The model predicts that certain subsets of patients with at least T2 or N1 disease will gain a survival benefit from adjuvant CRT, and the magnitude of benefit for an individual patient can vary. Conclusion A nomogram built from a parametric survival model from the SEER-Medicare database can be used as a decision aid to predict which gallbladder patients may benefit from adjuvant CRT. PMID:22067404

Benefit of adjuvant chemotherapy in patients with T4 UICC II colon cancer

International Nuclear Information System (INIS)

Teufel, Andreas; Gerken, Michael; Hartl, Janine; Itzel, Timo; Fichtner-Feigl, Stefan; Stroszczynski, Christian; Schlitt, Hans Jürgen; Hofstädter, Ferdinand; Klinkhammer-Schalke, Monika

2015-01-01

Colorectal cancer is the third most common cancer and a major cause of morbidity and mortality worldwide. Adjuvant chemotherapy is considered the standard of care in patients with UICC stage III colon cancer after R0 resection. Adjuvant therapy was not shown to be beneficial in patients with UICC stage II colon cancer. However, there is an ongoing discussion as to whether adjuvant chemotherapy may be beneficial for a subgroup of UICC II patients in a “high-risk situation” (such as T4). We investigated a Bavarian population-based (2.1 million inhabitants) cohort of 1937 patients with UICC II CRC treated between 2002 and 2012 in regard of the benefit of adjuvant chemotherapy for large (T4) tumors. Patients older than 80 years of age were excluded. Of 1937 patients, 240 had a T4 tumor (12 %); 77 of all T4 patients received postoperative chemotherapy (33 %). Kaplan-Meier analysis and Cox regression models were used for survival analyses. Patients with a T4 tumor who received postoperative chemotherapy had a highly significant survival benefit in respect of overall survival (p < 0.001) and recurrence-free survival (p = 0.008). However, no difference was observed between oxaliplatin-containing and non-oxaliplatin-containing treatment regimens. G2 and G3 tumors were found to particularly benefit from adjuvant treatment. Chemotherapy, age at diagnosis, and tumor grading remained independent risk factors in the multivariate cox regression analysis. Our retrospective study demonstrated the significant benefit of adjuvant chemotherapy in the T4 subgroup of patients with UICC II colon cancer. Our data suggest that adjuvant chemotherapy should be seriously considered in these patients. The online version of this article (doi:10.1186/s12885-015-1404-9) contains supplementary material, which is available to authorized users

Healthy young minds: the effects of a 1-hour classroom workshop on mental illness stigma in high school students.

Science.gov (United States)

Ke, Sally; Lai, Joshua; Sun, Terri; Yang, Michael M H; Wang, Jay Ching Chieh; Austin, Jehannine

2015-04-01

This study aimed to test the effects of a 1-h classroom-based workshop, led by medical students, on mental illness stigma amongst secondary school students. Students (aged 14-17) from three public secondary schools in British Columbia participated in the workshop. A questionnaire measuring stigma (including stereotype endorsement and desire for social distance) was administered immediately before (T1), immediately after (T2), and 1-month after the workshop (T3). A total of 279 students met the study inclusion criteria. Total scores on the stigma scale decreased by 23 % between T1 and T2 (p students.

Adjuvant chemotherapy for colorectal cancer: age differences in factors influencing patients' treatment decisions

Directory of Open Access Journals (Sweden)

Jorgensen ML

2013-08-01

Full Text Available Mikaela L Jorgensen,1,2 Jane M Young,1,2 Michael J Solomon1,31Surgical Outcomes Research Centre (SOuRCe, Sydney School of Public Health, University of Sydney and Sydney Local Health District, NSW, Australia; 2Cancer Epidemiology and Services Research (CESR, Sydney School of Public Health, University of Sydney, NSW, Australia; 3Discipline of Surgery, University of Sydney, NSW, AustraliaPurpose: Older colorectal cancer patients are significantly less likely than younger patients to receive guideline-recommended adjuvant chemotherapy. Previous research has indicated that patient refusal of treatment is a contributing factor. This study aimed to identify potential barriers to adjuvant chemotherapy use in older patients by examining the associations between patient age, factors influencing chemotherapy treatment decisions, and preferences for information and decision-making involvement.Patients and methods: Sixty-eight patients who underwent surgery for colorectal cancer in Sydney, Australia, within the previous 24 months completed a self-administered survey.Results: Fear of dying, health status, age, quality of life, and understanding treatment procedures and effects were significantly more important to older patients (aged ≥65 years than younger patients in deciding whether to accept chemotherapy (all P < 0.05. Reducing the risk of cancer returning and physician trust were important factors for all patients. Practical barriers such as traveling for treatment and cost were rated lowest. Older patients preferred less information and involvement in treatment decision making than younger patients. However, 60% of the older group wanted detailed information about chemotherapy, and 83% wanted some involvement in decision making. Those preferring less information and involvement still rated many factors as important in their decision making, including understanding treatment procedures and effects.Conclusion: A range of factors appears to influence

Successful adjuvant-free vaccination of BALB/c mice with mutated amyloid β peptides

Directory of Open Access Journals (Sweden)

Wahi Monika M

2008-02-01

Full Text Available Abstract Background A recent human clinical trial of an Alzheimer's disease (AD vaccine using amyloid beta (Aβ 1–42 plus QS-21 adjuvant produced some positive results, but was halted due to meningoencephalitis in some participants. The development of a vaccine with mutant Aβ peptides that avoids the use of an adjuvant may result in an effective and safer human vaccine. Results All peptides tested showed high antibody responses, were long-lasting, and demonstrated good memory response. Epitope mapping indicated that peptide mutation did not lead to epitope switching. Mutant peptides induced different inflammation responses as evidenced by cytokine profiles. Ig isotyping indicated that adjuvant-free vaccination with peptides drove an adequate Th2 response. All anti-sera from vaccinated mice cross-reacted with human Aβ in APP/PS1 transgenic mouse brain tissue. Conclusion Our study demonstrated that an adjuvant-free vaccine with different Aβ peptides can be an effective and safe vaccination approach against AD. This study represents the first report of adjuvant-free vaccines utilizing Aβ peptides carrying diverse mutations in the T-cell epitope. These largely positive results provide encouragement for the future of the development of human vaccinations for AD.

Reports on the AAAI 1999 Workshop Program

OpenAIRE

Drabble, Brian; Chaudron, Laurent; Tessier, Catherine; Abu-Hakima, Sue; Willmott, Steven; Austin, Jim; Faltings, Boi; Freuder, Eugene C.; Friedrich, Gerhard; Freitas, Alex A.; Cortes, U.; Sanchez-Marre, M.; Aha, David W.; Becerra-Fernandez, Irma; Munoz-Avila, Hector

2000-01-01

The AAAI-99 Workshop Program (a part of the sixteenth national conference on artificial intelligence) was held in Orlando, Florida. The program included 16 workshops covering a wide range of topics in AI. Each workshop was limited to approximately 25 to 50 participants. Participation was by invitation from the workshop organizers. The workshops were Agent-Based Systems in the Business Context, Agents' Conflicts, Artificial Intelligence for Distributed Information Networking, Artificial Intell...

PV radiometrics workshop proceedings

Energy Technology Data Exchange (ETDEWEB)

Myers, D.R.

1995-09-01

This report documents presentations and discussions held at the Photovoltaics Radiometeric Measurements Workshop conducted at Vail, Colorado, on July 24 and 25, 1995. The workshop was sponsored and financed by the Photovoltaic Module and Systems Performance and Engineering Project managed by Richard DeBlasio, Principal Investigator. That project is a component of the National Renewable Energy Laboratory (NREL) Photovoltaic Research and Development Program, conducted by NREL for the US Department of Energy, through the NREL Photovoltaic Engineering and Applications Branch, managed by Roland Hulstrom. Separate abstracts have been prepared for articles from this workshop.

A healthy turn in urban climate change policies; European city workshop proposes health indicators as policy integrators.

Science.gov (United States)

Keune, Hans; Ludlow, David; van den Hazel, Peter; Randall, Scott; Bartonova, Alena

2012-06-28

The EU FP6 HENVINET project reviewed the potential relevance of a focus on climate change related health effects for climate change policies at the city region level. This was undertaken by means of a workshop with both scientists, city representatives from several EU-countries, representatives of EU city networks and EU-experts. In this paper we introduce some important health related climate change issues, and discuss the current city policies of the participating cities. The workshop used a backcasting format to analyse the future relevance of a health perspective, and the main benefits and challenges this would bring to urban policy making. It was concluded that health issues have an important function as indicators of success for urban climate change policies, given the extent to which climate change policies contribute to public health and as such to quality of life. Simultaneously the health perspective may function as a policy integrator in that it can combine several related policy objectives, such as environmental policies, health policies, urban planning and economic development policies, in one framework for action. Furthermore, the participants to the workshop considered public health to be of strategic importance in organizing public support for climate change policies. One important conclusion of the workshop was the view that the connection of science and policy at the city level is inadequate, and that the integration of scientific knowledge on climate change related health effects and local policy practice is in need of more attention. In conclusion, the workshop was viewed as a constructive advance in the process of integration which hopefully will lead to ongoing cooperation. The workshop had the ambition to bring together a diversity of actor perspectives for exchange of knowledge and experiences, and joint understanding as a basis for future cooperation. Next to the complementarities in experience and knowledge, the mutual critical reflection

North Region ROW tool implementation workshop.

Science.gov (United States)

2010-08-02

Welcome to the North Region ROW Tool Workshop. This workshop is funded under an implementation project sponsored by TxDOTs Research & Technology Implementation Office (RTI). This is the second of four regional workshops being planned for this summ...

IMMUNOGENICITY OF ADJUVANT INFLUENZA VACCINE FOR PREGNANT WOMEN

Directory of Open Access Journals (Sweden)

M. P. Kostinov

2017-01-01

Full Text Available Recent epidemiological events showed that pregnant women are the most vulnerable part of population if there is the flu in the country and they die much more often than the rest part of people. That is why influenza vaccination of population including pregnant women is one of the priorities of public health service in our state. Worldwide experience of influenza vaccination of either adults or children by new adjuvant vaccine has caused our research of its efficiency among pregnant women. The aim of the study was to investigate the level of antibodies to influenza virus strain A/H1N1/v, A/H3N2 and B in pregnant women vaccinated adjuvant trivalent subunit vaccine. Our research is randomized and comparative on parallel groups. It was carried out within the demands of Russian Federation and International ethic norms adapted to such kind of researches. Evaluation of the immunogenicity of the vaccine was conducted in 27 pregnant women in the II trimester of gestation, and in 23 pregnant women in the III trimester of gestation, 19 non-pregnant women was in the control group. The level of antibodies in the serum was determined using a reaction of hemagglutination inhibition before and 1, 3, 6, 9 and 12 months after the vaccination. Revealed that influenza vaccination of pregnant women in the II and III trimester, causes the increase in titers of antibodies to vaccine influenza strains A and B, to fully meet the required criteria CPMP, and does not differ from the nonpregnant group. In a month after vaccination the level of seroprotective against A/H1N1/v was 77.0%, A/H3N2 — 88.9%, B — 85.2% after vaccination in II trimester, and 87.0; 87.0; 91.35% in III trimester of gestation. The factor of seroconversion after vaccination in II trimester for A/H1N1/v was equal to 6.5, A/H3N2 — 7.2, B — 6.5, after vaccination in III trimester of pregnancy: 7.1, 6.5 and 5.1 correspondingly. At the same time revealed accelerated decline in antibody titer against

Timing of adjuvant chemotherapy and its relation to survival among patients with stage III colon cancer.

Science.gov (United States)

Bos, A C R K; van Erning, F N; van Gestel, Y R B M; Creemers, G J M; Punt, C J A; van Oijen, M G H; Lemmens, V E P P

2015-11-01

Currently available data suggest that delaying the start of adjuvant chemotherapy in colon cancer patients has a detrimental effect on survival. We analysed which factors impact on the timing of adjuvant chemotherapy and evaluated the influence on overall survival (OS). Stage III colon cancer patients who underwent resection and received adjuvant chemotherapy between 2008 and 2013 were selected from the Netherlands Cancer Registry. Timing of adjuvant chemotherapy was subdivided into: ⩽ 4, 5-6, 7-8, 9-10, 11-12 and 13-16 weeks post-surgery. Multivariable regressions were performed to assess the influence of several factors on the probability of starting treatment within 8 weeks post-surgery and to evaluate the association of timing of adjuvant chemotherapy with 5-year OS. 6620 patients received adjuvant chemotherapy, 14% commenced after 8 weeks. Factors associated with starting treatment after 8 weeks were older age (Odds ratio (OR) 65-74 versus colon cancer patients within 8 weeks post-surgery. Copyright © 2015 Elsevier Ltd. All rights reserved.

INERA Workshop 2016: Membrane and Liquid Crystal Nanostructures (MELINA 2016)

International Nuclear Information System (INIS)

2017-01-01

We are pleased to introduce the Proceedings of the INERA Workshop “Membrane and Liquid Crystal Nanostructures” (MELINA 2016). This meeting was held from 3 th to 6 th of September 2016 in Varna (Bulgaria) and was organized by the Institute of Solid State Physics, Bulgarian Academy of Sciences (ISSP-BAS) in the frames of the Project INERA “Research and Innovation Capacity Strengthening of ISSP-BAS in Multifunctional Nanostructures” REGPOT-2012-2013-1 NMP (http://www.inera.org). The workshop venue was the “Saints Constantine and Helena” Resort - a beautiful complex on the Bulgarian Black Sea coast within a landscaped park 10 km north of downtown Varna, close to the Euxinograd royal summer palace, park and winery. The aim of this workshop was to bring together researchers with interests in interdisciplinary areas in order to report the recent results of their scientific work, to discuss the state-of-the-art and perspectives and communicate new ideas. Several experimental and theoretical streams in the field of nanostructured liquid crystal systems and nanocomposites; soft and living matter physics; membrane biophysics; nanostructures in polymer and lipid membranes; characterization of soft nanomaterials were merged and directed towards a constructive discussion and solutions of a wide variety of actual problems in these important scientific areas. Participants from 9 countries presented 20 oral and 15 poster presentations in 5 topical areas. INERA Workshop MELINA 2016 provided very good opportunities for direct contacts, interesting discussions and interactive exchange of ideas between the participants. It also became a meeting point where INERA partners could plan and organize their future efficient collaborations and joint research projects of common interest. The editors would like to thank all authors for their high-quality contributions. The papers submitted for publication in the Proceedings were refereed according to the publishing standards of the

Antinociceptive effect of chlorphenesin carbamate in adjuvant arthritic rats.

Science.gov (United States)

Okuyama, S; Aihara, H

1987-02-01

The antinociceptive effect of chlorphenesin carbamate (CPC) and mephenesin were examined in adjuvant arthritic rats. In the behavioral study, CPC (100-400 mg/kg, p.o.) but not mephenesin (100-400 mg/kg, p.o.) had a dose-dependent antinociceptive effect, determined using the flexion test. In the electrophysiological study, CPC (25-50 mg/kg, i.v.) but not mephenesin (50 mg/kg, i.v.) depressed the evoked neuronal responses of nociceptive neurons in the ventrobasal thalamus (VB), while the evoked responses of non-nociceptive neurons were not depressed by either CPC (50 mg/kg, i.v.) or mephenesin (50 mg/kg, i.v.). The spontaneous firings of the VB nociceptive neurons were depressed by both CPC (50 mg/kg, i.v.) and mephenesin (50 mg/kg, i.v.). However, mephenesin (50 mg/kg, i.v.) but not CPC (50 mg/kg, i.v.) also depressed the spontaneous firings of the mesencephalic reticular formation (RF), in these adjuvant arthritic rats. These results indicate that CPC but not mephenesin, has an antinociceptive action in adjuvant arthritic rats.

Tocotrienols are good adjuvants for developing cancer vaccines

International Nuclear Information System (INIS)

Abdul Hafid, Sitti Rahma; Radhakrishnan, Ammu Kutty; Nesaretnam, Kalanithi

2010-01-01

Dendritic cells (DCs) have the potential for cancer immunotherapy due to their ability to process and present antigens to T-cells and also in stimulating immune responses. However, DC-based vaccines have only exhibited minimal effectiveness against established tumours in mice and humans. The use of appropriate adjuvant enhances the efficacy of DC based cancer vaccines in treating tumours. In this study we have used tocotrienol-rich fraction (TRF), a non-toxic natural compound, as an adjuvant to enhance the effectiveness of DC vaccines in treating mouse mammary cancers. In the mouse model, six-week-old female BALB/c mice were injected subcutaneously with DC and supplemented with oral TRF daily (DC+TRF) and DC pulsed with tumour lysate from 4T1 cells (DC+TL). Experimental mice were also injected with DC pulsed with tumour lysate and supplemented daily with oral TRF (DC+TL+TRF) while two groups of animal which were supplemented daily with carrier oil (control) and with TRF (TRF). After three times vaccination, mice were inoculated with 4T1 cells in the mammary breast pad to induce tumour. Our study showed that TRF in combination with DC pulsed with tumour lysate (DC+TL+TRF) injected subcutaneously significantly inhibited the growth of 4T1 mammary tumour cells as compared to control group. Analysis of cytokines production from murine splenocytes showed significant increased productions of IFN-γ and IL-12 in experimental mice (DC+TL+TRF) compared to control, mice injected with DC without TRF, mice injected with DC pulsed with tumour lysate and mice supplemented with TRF alone. Higher numbers of cytotoxic T cells (CD8) and natural killer cells (NK) were observed in the peripheral blood of TRF adjuvanted DC pulsed tumour lysate mice. Our study show that TRF has the potential to be an adjuvant to augment DC based immunotherapy

Adjuvant endocrine and chemotherapy for early breast cancer

International Nuclear Information System (INIS)

Henderson, I. Craig

1996-01-01

Objective: Present the results of the 1995 World Overview which will be held in Oxford England two weeks before ASTRO. Discuss the interpretation and application of these results. Review current research topics on the use of adjuvant endocrine and chemotherapy for early breast cancer. The survival benefits from adjuvant chemotherapy in premenopausal women and adjuvant tamoxifen in postmenopausal women are well established. Each will reduce the annual odds of death by about 25% resulting in a 10 year survival difference of 8-10%. By the time of this presentation, the results of the 1995 Adjuvant Therapy Overview should be with 10+ years of follow-up, and if possible these will be summarized. Current efforts to improve on previous results are focused on the following areas: Optimal chemotherapy dose. Decreasing dose will compromise patient survival. It is not as certain that increasing dose will have as much impact in improving survival. The NSABP was unable to demonstrate an improvement in survival by modestly increasing the dose of cyclophosphamide alone. However, recent results of a Canadian study of CEF (cyclophosphamide, epidoxorubicin, and 5-fluorouracil) and an Intergroup trial of an intense 16 week polychemotherapy program keep alive the possibility that dose escalation is still a very important question. An NSABP trial evaluating even greater cyclophosphamide dose escalation, an Intergroup evaluation of different doxorubicin doses, and two Intergroup trials evaluating very high dose chemotherapy and bone marrow transplantation should provide definitive evidence regarding the importance of dose. Drug sequence. A study from Milan suggests that initial treatment with single agent doxorubicin followed by CMF will be superior to alternating doxorubicin and CMF. This has not been confirmed yet, and the reason for increased benefit from such a sequence is not entirely clear. This concept is being explored further in an Intergroup trial comparing four cycles of

Prognostic significance of adjuvant radiation therapy in adenocarcinoma of the cecum

Science.gov (United States)

Hosseini, Sare; Bananzadeh, Ali Mohammad; Mohammadianpanah, Mohammad; Salek, Roham; Taghizadeh-Kermani, Ali

2018-01-01

Purpose Local recurrence is a common failure pattern in adenocarcinoma of the cecum. This study aimed to investigate the potential role of adjuvant radiation therapy on oncologic outcomes of patients with adenocarcinoma of the cecum. Materials and Methods This retrospective study was carried out at three large tertiary university hospitals. We analyzed the characteristics, prognostic factors, and survival of 162 patients with adenocarcinoma of the cecum that were treated and followed up between 2000 and 2013. All the patients had undergone a right hemicolectomy and received chemotherapy with (n = 48) or without (n = 114) adjuvant radiation therapy. Results The subjects were 65 females and 97 males with a median age of 56 years (range, 17 to 90 years) at diagnosis. The 5-year local control (LC), disease free survival (DFS), and overall survival (OS) rates were 72.7%, 57.2%, and 62.6% respectively. In a multivariate analysis, age, tumor stage, node stage, and adjuvant radiation therapy were determined to be independent prognostic factors. Age more than 55 years (hazard ratio [HR] = 1.0; 95% confidence interval [CI], 0.06–0.32; p = 0.003], T4 stage (HR = 6.8; 95% CI, 3.07–15.36; p < 0.001), node positive disease (HR = 4.2; 95% CI, 1.94–9.13; p < 0.001), and the absence of adjuvant radiation therapy (HR = 3.0; 95% CI, 1.39–6.46; p = 0.005) had a negative influence on OS. Conclusion Adjuvant radiation therapy significantly improves DFS and OS in patients with adenocarcinoma of the cecum. PMID:29506326

Workshop on treatment of and postexposure prophylaxis for Burkholderia pseudomallei and B. mallei Infection, 2010

NARCIS (Netherlands)

Lipsitz, Rebecca; Garges, Susan; Aurigemma, Rosemarie; Baccam, Prasith; Blaney, David D.; Cheng, Allen C.; Currie, Bart J.; Dance, David; Gee, Jay E.; Larsen, Joseph; Limmathurotsakul, Direk; Morrow, Meredith G.; Norton, Robert; O'Mara, Elizabeth; Peacock, Sharon J.; Pesik, Nicki; Rogers, L. Paige; Schweizer, Herbert P.; Steinmetz, Ivo; Tan, Gladys; Tan, Patrick; Wiersinga, W. Joost; Wuthiekanun, Vanaporn; Smith, Theresa L.

2012-01-01

The US Public Health Emergency Medical Countermeasures Enterprise convened subject matter experts at the 2010 HHS Burkholderia Workshop to develop consensus recommendations for postexposure prophylaxis against and treatment for Burkholderia pseudomallei and B. mallei infections, which cause

Dynamic defense workshop :

Energy Technology Data Exchange (ETDEWEB)

Crosby, Sean Michael; Doak, Justin E.; Haas, Jason Juedes.; Helinski, Ryan; Lamb, Christopher C.

2013-02-01

On September 5th and 6th, 2012, the Dynamic Defense Workshop: From Research to Practice brought together researchers from academia, industry, and Sandia with the goals of increasing collaboration between Sandia National Laboratories and external organizations, de ning and un- derstanding dynamic, or moving target, defense concepts and directions, and gaining a greater understanding of the state of the art for dynamic defense. Through the workshop, we broadened and re ned our de nition and understanding, identi ed new approaches to inherent challenges, and de ned principles of dynamic defense. Half of the workshop was devoted to presentations of current state-of-the-art work. Presentation topics included areas such as the failure of current defenses, threats, techniques, goals of dynamic defense, theory, foundations of dynamic defense, future directions and open research questions related to dynamic defense. The remainder of the workshop was discussion, which was broken down into sessions on de ning challenges, applications to host or mobile environments, applications to enterprise network environments, exploring research and operational taxonomies, and determining how to apply scienti c rigor to and investigating the eld of dynamic defense.

ARES Education and Public Outreach

Science.gov (United States)

Allen, Jaclyn; Galindo, Charles; Graff, Paige; Willis, Kim

2014-01-01

The ARES Directorate education team is charged with translating the work of ARES scientists into content that can be used in formal and informal K-12 education settings and assisting with public outreach. This is accomplished through local efforts and national partnerships. Local efforts include partnerships with universities, school districts, museums, and the Lunar and Planetary Institute (LPI) to share the content and excitement of space science research. Sharing astromaterials and exploration science with the public is an essential part of the Directorate's work. As a small enclave of physical scientists at a NASA Center that otherwise emphasizes human space operations and engineering, the ARES staff is frequently called upon by the JSC Public Affairs and Education offices to provide presentations and interviews. Scientists and staff actively volunteer with the JSC Speaker's Bureau, Digital Learning Network, and National Engineers Week programs as well as at Space Center Houston activities and events. The education team also participates in many JSC educator and student workshops, including the Pre-Service Teacher Institute and the Texas Aerospace Scholars program, with workshop presentations, speakers, and printed materials.

The identification of plant lectins with mucosal adjuvant activity

Science.gov (United States)

Lavelle, E C; Grant, G; Pusztai, A; Pfüller, U; O'hagan, D T

2001-01-01

To date, the most potent mucosal vaccine adjuvants to be identified have been bacterial toxins. The present data demonstrate that the type 2 ribosome-inactivating protein (type 2 RIP), mistletoe lectin I (ML-I) is a strong mucosal adjuvant of plant origin. A number of plant lectins were investigated as intranasal (i.n.) coadjuvants for a bystander protein, ovalbumin (OVA). As a positive control, a potent mucosal adjuvant, cholera toxin (CT), was used. Co-administration of ML-I or CT with OVA stimulated high titres of OVA-specific serum immunoglobulin G (IgG) in addition to OVA-specific IgA in mucosal secretions. CT and ML-I were also strongly immunogenic, inducing high titres of specific serum IgG and specific IgA at mucosal sites. None of the other plant lectins investigated significantly boosted the response to co-administered OVA. Immunization with phytohaemagglutinin (PHA) plus OVA elicited a lectin-specific response but did not stimulate an enhanced response to OVA compared with the antigen alone. Intranasal delivery of tomato lectin (LEA) elicited a strong lectin-specific systemic and mucosal antibody response but only weakly potentiated the response to co-delivered OVA. In contrast, administration of wheatgerm agglutinin (WGA) or Ulex europaeus lectin 1 (UEA-I) with OVA stimulated a serum IgG response to OVA while the lectin-specific responses (particularly for WGA) were relatively low. Thus, there was not a direct correlation between immunogenicity and adjuvanticity although the strongest adjuvants (CT, ML-I) were also highly immunogenic. PMID:11168640

The current capacity for training in public health nutrition in West Africa

NARCIS (Netherlands)

Pepping, F.

2010-01-01

This article is based on a paper prepared for the Workshop on Establishing a Regional Institute for Public Health Nutrition Research and Training in West Africa, convened in Dakar, Senegal, 26-28 March, 2009. Information was gathered mainly prior to this workshop; several responses, however, came in

Nuclear Energy. Communicating with the Public

International Nuclear Information System (INIS)

1991-01-01

Information and communication with the public often appear to be the Achilles heel of nuclear energy, despite the considerable effort devoted to them. This report is based on the conclusions of several workshops organised by the OECD Nuclear Energy Agency for public information specialists. It discusses the principles and practices leading to better communication with the public in four nuclear energy fields: radiation protection, radiological emergencies, routine operation of nuclear plants and radioactive waste management

Antigen-Sparing and Enhanced Efficacy of Multivalent Vaccines Adjuvanted with Immunopotentiators in Chickens

Directory of Open Access Journals (Sweden)

Peipei Wu

2017-05-01

Full Text Available We previously described that immunopotentiators, CVCVA5, increased the efficacy of H5 and H9 subtype avian influenza vaccines in chickens, ducks, and geese. In this study, we further investigated the effects of the CVCVA5 for improving the efficacy of other univalent or multivalent inactivated vaccines. The immune response administrated with half-dose of monovalent vaccine plus CVCVA5 were higher than those of one dose of monovalent vaccine without immunopotentiators as measured by levels of antibodies from serum, tears and bronchoalveolar lavage fluids, and cytokines of IFNγ and IL-4 from serum. Vaccines included the univalent vaccine of Newcastle Disease virus (ND, Egg Drop Syndrome virus (EDS, Infectious Bronchitis virus (IB, and Infectious Bursal Disease virus (IBD. The CVCVA5 also improved the immune response of both ND and IBD vaccines with less dosage. The sterile protective immunity was monitored with one- or a half-dose of adjuvanted ND vaccine or one dose of adjuvanted IBD vaccine, respectively. The improved immune efficacy was observed in a half-dose of adjuvanted bivalent vaccines compared to one dose of vaccines without CVCVA5 as measured by the antibody levels, including bivalent vaccine of ND-H9, ND-IB, and ND-IBD. The CVCVA5 also boosted the immune efficacy of the tetravalent vaccine (ND-IB-EDS-H9. A half-dose of adjuvanted commercial vaccine or 75% antigen-sparing adjuvanted vaccine elicited similar antibody levels to those of one dose non-adjuvanted commercial vaccines. The CVCVA5 improved the effect of a booster vaccination as measured by the antibody levels against H5 or H9 virus antigens, in which chickens primed with the adjuvanted ND-IB vaccines given a booster with H5–H9 bivalent vaccines without CVCVA5 using 5-day intervals. The inflammatory response may contribute to these additional effects by increasing the levels of IFNγ and IL-4 after the injection of the adjuvanted ND-IB vaccines. Results indicated that the

Reports on the 2015 AAAI Workshop Program

OpenAIRE

Albrecht, Stefano V.; Beck, J. Christopher; Buckeridge, David L.; Botea, Adi; Caragea, Cornelia; Chi, Chi-hung; Damoulas, Theodoros; Dilkina, Bistra; Eaton, Eric; Fazli, Pooyan; Ganzfried, Sam; Giles, C. Lee; Guillet, Sébastian; Holte, Robert; Hutter, Frank

2015-01-01

AAAI's 2015 Workshop Program was held Sunday and Monday, January 25–26, 2015 at the Hyatt Regency Austin Hotel in Austion, Texas, USA. The AAAI-15 workshop program included 15 workshops covering a wide range of topics in artificial intelligence. Most workshops were held on a single day. The titles of the workshops included AI and Ethics, AI for Cities, AI for Transportation: Advice, Interactivity and Actor Modeling, Algorithm Configuration, Artificial Intelligence Applied to Assistive Technol...

Oncoplastic breast surgery does not delay the onset of adjuvant chemotherapy

DEFF Research Database (Denmark)

Klit, Anders; Tvedskov, Tove Filtenborg; Kroman, Niels

2017-01-01

BACKGROUND: Only a few studies of limited size have examined whether oncoplastic breast surgery delays the onset of adjuvant chemotherapy as compared to conventional breast surgery. We investigated whether oncoplastic breast surgery causes a delay in the onset of adjuvant chemotherapy in comparison...... to lumpectomy and mastectomy. MATERIAL AND METHODS: The study is a population-based cohort study. Within the nationwide registry of the Danish Breast Cancer Group (DBCG), we identified 1798 patients who received adjuvant chemotherapy following mastectomy, lumpectomy or oncoplastic breast surgery for early...... and unilateral invasive breast cancer. Women treated with neoadjuvant chemotherapy were excluded. RESULTS: We found no significant difference between the three groups (mastectomy, lumpectomy, oncoplastic breast surgery) in the time from biopsy to surgery (mean time 17.9, 17.0 and 18.3 days, respectively...

Impact of adjuvant chemotherapy for gliomatosis cerebri

International Nuclear Information System (INIS)

Kong, Doo-Sik; Nam, Do-Hyun; Kim, Sung Tae; Lee, Jung-Il; Suh, Yeon-Lim; Lim, Do Hoon; Kim, Won Seog; Kwon, Ki-Hoon; Park, Kwan; Kim, Jong Hyun

2010-01-01

Gliomatosis cerebri (GC) is characterized by a diffuse infiltration of tumor cells throughout CNS, however, few details are available about the chemotherapeutic effect on GC. The aim of this study was to investigate its clinical course and to determine the efficacy of chemotherapy for GC. Between Jan. 1999 and Dec. 2004, 37 GC patients were diagnosed by biopsy and treated with radiotherapy in a single institution. To determine the efficacy of chemotherapy for GC, we retrospectively reviewed their clinical courses. The study cohort was divided into 2 groups, those with and without receiving post-radiotherapy adjuvant chemotherapy such as temozolomide or nitrosourea-based chemotherapy. Nineteen patients with adjuvant chemotherapy were assigned to the chemotreatment group and 18 with radiotherapy alone were assigned to the control group. Mean survival for chemotreatment group and control group were 24.2 and 13.1 months, respectively (p = 0.045). Time to progression for these groups were 16.0 and 6.0 months, respectively (p = 0.007). Overall review of the clinical course of patients with GC provided that early appearance of new contrast-enhancing lesions within 6 months from the initial diagnosis and higher histological grade were closely associated with poor survival (p < 0.001 and p = 0.008). Adjuvant chemotherapy following radiotherapy could prolong the survival in patients with GC. In addition, newly developed contrast-enhanced lesions on the follow-up MR images indicate the progression of GC

NKS Workshop on Radioanalytical Chemistry - Final report

DEFF Research Database (Denmark)

The NKS-B workshop on radioanalytical chemistry was held 2-6th Sept 2013 at Risø, Denmark. There were a total of 49 persons participating in the workshop, including 32 young participants and 15 lecturers. The work-shop started with 3 days of lab practice followed by 1.5 day’s lectures by the expe......The NKS-B workshop on radioanalytical chemistry was held 2-6th Sept 2013 at Risø, Denmark. There were a total of 49 persons participating in the workshop, including 32 young participants and 15 lecturers. The work-shop started with 3 days of lab practice followed by 1.5 day’s lectures...

2017 Marine Hydrokinetic Instrumentation Workshop Report

Energy Technology Data Exchange (ETDEWEB)

Driscoll, Frederick R [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Mauer, Erik [U.S. Department of Energy; Rieks, Jeff [Allegheny Science and Technologies