WorldWideScience

Sample records for public management npm

  1. Is there new public health management (NPM) in Nepal? Arguments for and against NPM in Nepal.

    Science.gov (United States)

    Paudel, Mohan

    2013-01-01

    This article is a reflection about whether new public management (NPM) styles of reforms seen in other developing countries are also seen in Nepal, and to substantiate these facts with the available evidence and findings. The author saw the emergence of NPM ideas in Western industrialized countries like the United Kingdom and New Zealand. Now it exists in several developing countries of Africa and Asia; but it is very hard to generalize the degree and scope of NPM elements' existence. In Southeast Asia, there is still a mix of the old bureaucratic system with new NPM-oriented reform initiatives. Series of administrative reforms, donor conditionality, and the reestablishment of democracy in the country after 1991 have influenced an orientation toward an efficient, people-oriented, mixed-economy model with increasing partnership of private agencies and nongovernmental organizations in Nepal. The political movement of the last 15 years in the country has strongly called for a new, efficient, and performance-oriented administration and management culture in the country. There are several initiatives already introduced (public-private partnership, decentralization, good governance, accountability/public auditing, performance-based outcome/results-oriented financing and reporting systems). However, to take this momentum up, it still requires strong willingness of political leaders and senior administrators. At the moment, peace and stability of turmoil, political stability, state-of-the-art management skills, and supportive organizational culture are the fundamental requirements for increasing the realization of, and sustaining the NPM-oriented reforms in Nepal.

  2. The interplay of management accounting research and NPM health initiatives

    DEFF Research Database (Denmark)

    Malmmose, Margit

    This paper investigates the development of management accounting research in the context of New Public Management (NPM) initiatives in health care. Drawing on concepts from diffusion theory and earlier literature reviews, the paper examines the interplay between management accounting research...... and health care reforms in relation to country of origin, development, theoretical approach, research method and topic. The study thus establishes a different focus; namely the interrelationship between the development of management accounting research and practical socio-political NPM innovations. The study...... shows that management accounting techniques are increasingly adopted in governmental health reforms and diffused across nations, themes and initiatives through time with the result that wider social practices become more and more integrated in management accounting research themes...

  3. The interplay of management accounting research and NPM health initiatives

    DEFF Research Database (Denmark)

    Malmmose, Margit

    This paper investigates the development of management accounting research in the context of New Public Management (NPM) initiatives in health care. Drawing on concepts from diffusion theory and earlier literature reviews, the paper examines the interplay between management accounting research...... and health care reforms in relation to country of origin, development, theoretical approach, research method and topic. The study thus establishes a different focus; namely the interrelationship between the development of management accounting research and practical socio-political NPM innovations. The study...... shows that management accounting techniques are increasingly adopted in governmental health reforms and diffused across nations, themes and initiatives through time with the result that wider social practices become more and more integrated in management accounting research themes...

  4. From Autonomy to Quality Management: NPM Impacts on School Governance in Switzerland

    Science.gov (United States)

    Hangartner, Judith; Svaton, Carla Jana

    2013-01-01

    This article reviews the impact of discourses on "New Public Management" (NPM) on compulsory schooling in Switzerland during the last two decades and traces its implementation in the Canton of Bern. The analysis suggests that while NPM reformers initially promoted increased school autonomy, the introduction of market elements and school…

  5. From Autonomy to Quality Management: NPM Impacts on School Governance in Switzerland

    Science.gov (United States)

    Hangartner, Judith; Svaton, Carla Jana

    2013-01-01

    This article reviews the impact of discourses on "New Public Management" (NPM) on compulsory schooling in Switzerland during the last two decades and traces its implementation in the Canton of Bern. The analysis suggests that while NPM reformers initially promoted increased school autonomy, the introduction of market elements and school…

  6. New forms of knowledge challenge NPM-based management technologies

    DEFF Research Database (Denmark)

    Neisig, Margit

    2014-01-01

    is emerging and indicate that a new paradigm seems to be driven forward by the need for a new type of knowledge allowing us to address the complex issues associated with the future’s welfare generation. The article provides empirical support for theories claiming that we have not yet gone »beyond NPM«, nor......-, second- or third-order management. The empirical results demonstrate that, historically, the models have shifted from a primary focus on first-order process intervention towards a stronger emphasis on second- and third-order intervention – yet without abandoning first-order intervention. In other words...... level. Furthermore, the article discusses new trends in the management models Applied in the municipal sectors since 2007. The empirical analysis demonstrates that New Public Management (NPM) remains very much alive in Denmark. However, results also suggest that a new agenda for public administration...

  7. The historical development of management accounting discursive role in NPM reforms

    DEFF Research Database (Denmark)

    Malmmose, Margit

    from a historical perspective is limited. This paper investigates the historical and discursive development of management accounting in health care through general history, organisational and national documents along with academic literature. The framework is informed by the governmentality concept......Much research has focused on the role and limitations that management accounting techniques have had in the development of New Public Management (NPM) reforms during the past 30 years. However, research of the origin of NPM, the reason for NPM reforms consumed with the role of management accounting...... described by Miller and O’Leary (1987) and this is used to reflect on developments in the past century including the role of discursive formation and practice. The intention is to explain and put into perspective how the current role of management accounting developed. The aim is to guide future research...

  8. The historical development of management accounting discursive role in NPM reforms

    DEFF Research Database (Denmark)

    Malmmose, Margit

    Much research has focused on the role and limitations that management accounting techniques have had in the development of New Public Management (NPM) reforms during the past 30 years. However, research of the origin of NPM, the reason for NPM reforms consumed with the role of management accounting...... from a historical perspective is limited. This paper investigates the historical and discursive development of management accounting in health care through general history, organisational and national documents along with academic literature. The framework is informed by the governmentality concept...... described by Miller and O’Leary (1987) and this is used to reflect on developments in the past century including the role of discursive formation and practice. The intention is to explain and put into perspective how the current role of management accounting developed. The aim is to guide future research...

  9. Changing Market-Values? Tensions of Public Management Discourses

    DEFF Research Database (Denmark)

    Plotnikof, Mie

    2016-01-01

    The purpose of this paper is to address studies of New Public Governance (NPG) as a post-New Public Management (NPM) tendency. Although NPG is considered a contrast to NPM and its market incentives, it argues that the practices emerging in tensions of NPM and NPG discourses indicate not a clear...

  10. Public Management and Evaluation

    NARCIS (Netherlands)

    F.B.L. van der Meer (Frans-Bauke)

    2007-01-01

    textabstractIn public management we can observe a continuous search for its own improvement. New arrangements and procedures, often derived from NPM ideas, but also from other PA insights, are put in place with the expectations that public administration as well as its related agencies and networks

  11. Implementing New Public Management in Educational Policy

    Science.gov (United States)

    van der Sluis, Margriet E.; Reezigt, Gerry J.; Borghans, Lex

    2017-01-01

    This article describes how the Dutch Department of Education incorporates New Public Management (NPM) principles in educational policy, and whether conflicts of interest between the Department and schools cause deviations from NPM. We reviewed policy documents and performed secondary analyses on school data. Educational policy focuses on output…

  12. What Is a Good Workplace? Tracing the Logics of NPM among Managers and Professionals in Swedish Elderly Care

    Directory of Open Access Journals (Sweden)

    Britt-Inger Keisu

    2016-03-01

    Full Text Available Neoliberal policies such as new public management (NPM have been pivotal to the Swedish elderly care system for two decades. This article explores the discourses of NPM and work by focusing on how a good workplace is represented by professionals and managers in Swedish elderly care. Using qualitative interviews with 31 managers, nurses, physiotherapists, and occupational therapists at nine workplaces, we identified four competing meanings (‘storylines’ of how a good workplace is constructed among the interviewees within an ongoing struggle between two discourses. Three storylines, i.e., striving to achieve the mission, a desire to work in elderly care, and striving for good working relationships, are linked to the neoliberal discourse of organizational effectiveness. In contrast, the fourth storyline, support and better working conditions, is related to a welfare-state discourse of traditional labor relations with strong historical roots. Four subject positions available to the managers and professionals were identified: the bureaucrat, the passionate, the professional, and the critic. We conclude that NPM is translated on top of existing discourses, such as those of traditional labor relations, care ideals, and practices, that are already established in elderly care workplaces and that counteract the new policy.

  13. Academics in a New Work Environment: The Impact of New Public Management on Work Conditions

    Science.gov (United States)

    Santiago, Rui; Carvalho, Teresa

    2008-01-01

    New public management (NPM) approaches have informed policy in the public sector in advanced countries in the last decade. Some authors suggest that the main objective of NPM at the organisational level is to change the traditional way professionals are regulated. This study examines the impact of NPM on the working conditions of Portuguese higher…

  14. New Public Management in Europe

    NARCIS (Netherlands)

    Ch. Pollitt (Christopher); S. van Thiel (Sandra); V.M.F. Homburg (Vincent)

    2007-01-01

    textabstractNew Public Management (NPM) is the label which many academics have given to a series of reforms from the 1980s onwards, to improve the efficiency and performance of western governments and/or public sector organizations. Examples are the development of performance indicators and benchmar

  15. NPM eller/og NPG

    DEFF Research Database (Denmark)

    Greve, Carsten

    2014-01-01

    I dag står vi i en økonomisk krise igen. New Public Management og New Public Governance har derfor på sin vis hver noget at bidrage med i den aktuelle styringssituation, selv om troen på markedsmekanismerne i NPM som det eneste saliggørende er ved at være aftagende.......I dag står vi i en økonomisk krise igen. New Public Management og New Public Governance har derfor på sin vis hver noget at bidrage med i den aktuelle styringssituation, selv om troen på markedsmekanismerne i NPM som det eneste saliggørende er ved at være aftagende....

  16. New public management reforms in Nigerian democratic governance

    African Journals Online (AJOL)

    New public management reforms in Nigerian democratic governance: issues and challenges. ... Journal of Research in National Development ... of the philosophy of administration broadly called “New Public Management” (NPM) in an effort to ...

  17. New Public Management and Evaluation

    NARCIS (Netherlands)

    F.B.L. van der Meer (Frans-Bauke)

    2007-01-01

    textabstractIn this chapter I will discuss what evaluation does and can contribute to insight in the dynamics and effects of (new) public management reforms. To do so, I pose three key ques-tions: 1. How is evaluation actually applied in relation to NPM-reforms? 2. How are evaluation results used an

  18. Ideas in Public Management Reform for the 2010s

    DEFF Research Database (Denmark)

    Greve, Carsten

    2015-01-01

    management to what has been the dominant paradigm in recent years, the New Public Management (NPM). “Self-styled” means that they explicitly present themselves as alternatives to NPM and address the shortcomings in NPM to promote alternative conceptualizations. They include Digital-Era Governance, Public......-making, performance governance, and innovation and strategic HRM. NPG: networks and collaboration, public-private partnerships and new ways of engaging active citizens. The paper sees these ideas as competing for dominance in the public organization literature as they are new drivers for reforms. Together they form...

  19. "New Public Management" and the Academic Profession: Reflections on the German Situation

    Science.gov (United States)

    Schimank, Uwe

    2005-01-01

    This essay considers recent implications of "new public management" (NPM) strategies for the universities of Germany. It argues that NPM poses a threat to the traditional values of the academic profession, and asks what the universities should do to restore public trust in their methods and management.

  20. New forms of knowledge challenge NPM-based management technologies

    DEFF Research Database (Denmark)

    Neisig, Margit

    2014-01-01

    This article compares the management models of four Danish municipal sectors based on documentation and evaluation. The article sees the models as instances of interventional communication and sectors are compared with a view to determining at which level the interventions take place, i.e. first......-, second- or third-order management. The empirical results demonstrate that, historically, the models have shifted from a primary focus on first-order process intervention towards a stronger emphasis on second- and third-order intervention – yet without abandoning first-order intervention. In other words......, a symbiosis has evolved between the various types of intervention. To put the analysis into perspective, the discussion adopts a cybernetic point of view and explores to which extent differences between the various sector models are associated with different systemic consequences to flexibility at the local...

  1. Application and Effectiveness of New Public Management in ...

    African Journals Online (AJOL)

    ... for the adoption of market-oriented approaches to the provision of social services. ... corporation's management typifies the application of these principles and, if it does, ... Key words: NPM; Customer satisfaction; NWSC; Public sector reform ...

  2. Modernising Education: New Public Management Reform in the Norwegian Education System

    Science.gov (United States)

    Møller, Jorunn; Skedsmo, Guri

    2013-01-01

    Since the end of the 1980s, the Norwegian education system has gone through major reform, influenced largely by new managerialist ideas. Strategies to renew the public sector were promoted as the new public management (NPM). This paper investigates the way ideas connected to NPM reforms have been introduced and interpreted in the Norwegian…

  3. New Public Management and Public Services for People with an Intellectual Disability: A Review of the Implementation of "Valuing People" in England

    Science.gov (United States)

    Cumella, Stuart

    2008-01-01

    Public policy for people with an intellectual disability has been shaped since 1945 by universalistic ideas of human rights and social inclusion. These universalistic ideas are increasingly under challenge from consumerist ideas, which is reflected in public policy in the New Public Management (NPM). NPM involves a critique of poor coordination…

  4. Changing market values? Tensions of contradicting public management discourses

    DEFF Research Database (Denmark)

    Plotnikof, Mie

    2016-01-01

    that the discursive tensions between such value-laden practices indicate a changing marketization associated with collaboration and trust, yet also competition. Research limitations/implications To research it becomes critical to advance theoretical and empirical knowledge on the constitutive effects of such complex......The purpose of this paper is to address studies of New Public Governance (NPG) as a post-New Public Management (NPM) tendency. Although NPG is considered a contrast to NPM and its market incentives, it argues that the practices emerging in tensions of NPM and NPG discourses indicate not a clear...... in practice. Drawing on a case study from the Danish daycare sector, it investigates local collaborative governance initiatives that develop new quality-management methods. Findings The study elucidates how NPM and NPG discourses collide in local practices of public sector management within daycare. It shows...

  5. Management Control, Results-Oriented Culture and Public Sector Performance : Empirical Evidence on New Public Management

    NARCIS (Netherlands)

    Verbeeten, Frank H M; Speklé, Roland F.

    2015-01-01

    New Public Management (NPM) has been guiding public sector reform for over 25 years. Its position on the design of effective management control rests on three key ideas: (1) performance improvement requires a results-oriented culture that emphasizes outcomes rather than inputs or processes; (2) publ

  6. Orion NPM 在校园网管理中实现短信报警的方法%A Simple Method of Short Message Alarm in Campus Network Management with Orion NPM

    Institute of Scientific and Technical Information of China (English)

    李太凤; 朱艳

    2015-01-01

    在校园网管理中使用 SolarWinds Orion NPM 网管软件,使整个校园网处于可管理状态。当网络设备出现故障时,Orion NPM 提供了多种报警方式,短信报警是最为实用和快速的报警方式。如果直接使用 NPM 自带的发送短信功能,则需要相应的短信网关等硬件设备。使用邮件报警方式,再利用电子邮箱的“邮件到达通知”功能,可实现免费短信报警功能,使校园网网络管理员能实现掌握网络设备运行状态。%By using the SolarWinds Orion NPM network management software in the management of the cam-pus network,the whole campus network is under its management. When there is a breakdown of the equipment, the Orion NPM provides a variety of alarm modes,including the WEB notification,sending text messages and sending mail etc. . Alarm messages are the most practical and rapid alarm mode,if the direct use of the NPM built- in function sends text messages,the corresponding SMS gateway hardware is required. To use the mail alarm mode,and the use of electronic mail "email arrival notice" function,can realize the free SMS alarm function,the network administrator can achieve controlling the running state of the network equipment,and play an important role in the daily management of the campus network.

  7. Jigsawing Education Evaluation. Pieces from the Italian New Public Management Puzzle

    Science.gov (United States)

    Grimaldi, Emiliano; Serpieri, Roberto

    2013-01-01

    This article deals with the "troubled history" of head teachers' evaluation in Italy, as a specific strand of the controversial and fuzzy embedding of New Public Management (NPM) discourse in the Italian education system. Since the 1990s, NPM has shaped both policy agendas and professionals' subjectivities, leading the way to a process…

  8. New Public Management in Lithuania's Higher Education

    Science.gov (United States)

    Leisyte, Liudvika; Kizniene, Danguole

    2006-01-01

    The article focuses on recent shifts in modes of coordination and the emerging drive towards new public management (NPM) in higher education and examines Lithuanian higher education policy as an example. It investigates the dynamics of the shift by exploring how stakeholders define the term and how, in turn, it influences the political agenda.…

  9. New Public Management, Care and Struggles about Recognition

    DEFF Research Database (Denmark)

    Dahl, Hanne Marlene

    2009-01-01

    New Public Management (NPM) is usually perceived as a homogeneous discourse. However, when we examine it by looking at micro-politics in municipalities and understand its consequences drawing on the voices of home helpers, the picture is more complex and ambiguous. NPM is seen as disciplining paid...... of resistance. The analysis applies feminist theories of recognition and care, and its findings are based on focus group interviews and feminist discourse analysis...

  10. The role and impact of the New Public Management in the Turkish National Police and its personnel management system

    Directory of Open Access Journals (Sweden)

    Mutlu Köseli

    2014-04-01

    Full Text Available It is clear that the New Public Management (NPM approaches which are mostly themes of private sector, would impact/contribute to the Turkish National Police (TNP that has a workforce over 200 thousand. This study attempts to identify how far the NPM applications are implemented and how is it perceieved by the managing level officials in the TNP. To the aforementioned ends, this study conducted several interviews with open ended questions and found at the first place that mid and upper level managers of the TNP believe that the NPM has resulted in managers questioning of shared values, functions, services and the role of the TNP and in turn strive for making progress on the role of the organization. This study also found that the NPM approaches has made notible changes in the TNP and its services/fuctions such as de-bureaucratization to certain levels, increased citizen satisfaction. It however identified that these NPM changes are not based on systematic and structural institutional developments but based only on individual efforts which are not sustainable. Moreover, it found that the notions of NPM can not easily be applied and practiced in the TNP due to rigid systemic structures that resist any change. As a result, despite the fact the NPM has cause certain progresses with individual efforts, it is quite clear that there must be structural and systematic changes for NPM applications to be practiced sustainably in the TNP.

  11. Implementation of New Public Management in Norwegian Universities

    Science.gov (United States)

    Frolich, Nicoline

    2005-01-01

    This article analyses the implementation of market-type mechanisms in the management of universities. The question of which cultural biases have been used in the implementation of New Public Management (NPM) in Norwegian universities is discussed. Cultural theory, institutional theory, and public policy studies are applied to the analysis of a…

  12. Educational Reform and Modernisation in Europe: The Role of National Contexts in Mediating the New Public Management

    Science.gov (United States)

    Hall, David; Grimaldi, Emiliano; Gunter, Helen M; Møller, Jorunn; Serpieri, Roberto; Skedsmo, Guri

    2015-01-01

    This article examines the spread of new public management (NPM) across European education systems as it has traversed national boundaries. While recognising the transnational dimensions of the spread of NPM, the authors offer new insights into the importance of national contexts in mediating this development in educational settings by focusing…

  13. Quality management techniques in public sector organizations: the role of managerial autonomy and organizational culture

    OpenAIRE

    Demuzere, Sara; Verhoest, Koen; Bouckaert, Geert

    2008-01-01

    According to NPM, more effective and efficient public services can be delivered if public sector organizations are granted more managerial autonomy and if they use various (private sector) management techniques. To date, only very limited attention has been paid to the link between managerial autonomy and the use of management techniques. With this study, we seek to fill this gap in the extensive NPM literature by examining the extent to which managerial autonomy has an effect on the use of m...

  14. Reclaiming the Public Manager

    Directory of Open Access Journals (Sweden)

    Andrew CARDOW

    2007-02-01

    Full Text Available This article adds to the existing discussion regarding the NPM, and more specifically addresses the role of managerial identity that is often ignored within the existing literature. The research was conducted utilising a grounded, qualitative methodology. The data was analysed utilising the tools of critical discourse. Throughout the article a case will be made that the introduction of private sector ‘business paradigms’ have led the managers to seek their legitimacy and their sense of identity not from the public sector but from the private sector. In doing so they have distanced themselves from the public, the owners of the assets they manage. The research is a qualitative study that highlights the conflict between identity and community expectation. The implications suggest that managers of local government business operations need to be aware of the possible conflict that can arise through seeking identity with the private sector in that it may lead to distancing themselves from the public they serve. The practical implications lie in being able to recognise that too close an identity with “normal” business practice can conflict with provision of public services

  15. Appraising Academic Appraisal in the New Public Management University

    Science.gov (United States)

    Field, Laurie

    2015-01-01

    Against a backdrop of new public management (NPM) thinking and managerialism generally applied to universities in a range of countries, this study examines one of its manifestations--performance management for academics. Drawing on in-depth interviews with 40 academics at an Australian university, this article identifies six stances regularly…

  16. New Public Management in Educational Reform in Norway

    Science.gov (United States)

    Solhaug, Trond

    2011-01-01

    The article focuses on the similarities and differences in using new public management (NPM) administrative arrangements in educational policy as they have been presented in the educational reform process carried out this millennium by two governments in Norway: the Centre-Conservative government and the current Red-Green coalition government.…

  17. The impact of New Public Management on efficiency: an analysis of Madrid's hospitals.

    Science.gov (United States)

    Alonso, José M; Clifton, Judith; Díaz-Fuentes, Daniel

    2015-03-01

    Madrid has recently become the site of one of the most controversial cases of public healthcare reform in the European Union. Despite the fact that the introduction of New Public Management (NPM) into Madrid hospitals has been vigorous, little scholarship has been done to test whether NPM actually led to technical efficiency. This paper is one of the first attempts to do so. We deploy a bootstrapped data envelopment analysis to compare efficiency scores in traditionally managed hospitals and those operating with new management formulas. We do not find evidence that NPM hospitals are more efficient than traditionally managed ones. Moreover, our results suggest that what actually matters may be the management itself, rather than the management model. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  18. Social capital practices as adaptive drivers for local adjustment of new public management in schools

    DEFF Research Database (Denmark)

    Olesen, Kristian Gylling; Hasle, Peter; Sørensen, Ole H.

    2016-01-01

    local adjustments of the reform initiatives, while also revealing some ambiguities. The results demonstrate that some reform initiatives can lead to new collaborative leadership and management practices in schools that solve the central school leadership and management tasks of coordination and planning....... This indicates that collaborative leadership and management practices may emerge from NPM reforms, and that such practices can prevent negative outcomes of such reforms.......New public management (NPM) reforms have typically undermined teachers’ autonomy, values, and status in society. This article questions whether such reforms automatically have these outcomes or whether and how possibilities for local adjustment of such reforms may prevent negative outcomes. Drawing...

  19. NPM and Craftsmanship: an Explorative Case Study in a Utilities Company into a Neglected Relationship

    NARCIS (Netherlands)

    P. Mascini (Peter); Y. Bacharias

    2010-01-01

    textabstractIntroduction Since the 1980s welfare state institutions have undergone profound changes based on the principles of New Public Management (NPM). These changes were brought on by neoliberal criticism at the rigid, bureaucratic, inefficient and paternalistic nature of the welfare state. Led

  20. The New Public Management is not that bad after all : Evidence from Estonia, Hungary and Romania

    NARCIS (Netherlands)

    S. Dan (Sorin)

    2014-01-01

    textabstractThis article reviews the New Public Management (NPM) literature in Central and Eastern Europe, looking particularly at reforms in Estonia, Hungary and Romania. It finds that research that assessed changes in internal processes and activities within the public sector by far outnumber rese

  1. New Public Management og sygeplejersker - plager og potentialer

    DEFF Research Database (Denmark)

    Dalsgaard, Lene; Jørgensen, Henning

    2016-01-01

    New Public Management opfattes som hovedproblemet for sygeplejersker for øjeblikket. Arbejdsglæde og arbejdsmiljø føles truet. Der er imidlertid andet end NPM på spil - politikere, medierne m.v. skal også adresseres. Forslag til fremgangsmåder for faglig-politisk oprustning fremsættes.......New Public Management opfattes som hovedproblemet for sygeplejersker for øjeblikket. Arbejdsglæde og arbejdsmiljø føles truet. Der er imidlertid andet end NPM på spil - politikere, medierne m.v. skal også adresseres. Forslag til fremgangsmåder for faglig-politisk oprustning fremsættes....

  2. Public Sector Reform and Governance for Adaptation: Implications of New Public Management for Adaptive Capacity in Mexico and Norway

    Science.gov (United States)

    Eakin, Hallie; Eriksen, Siri; Eikeland, Per-Ove; Øyen, Cecilie

    2011-03-01

    Although many governments are assuming the responsibility of initiating adaptation policy in relation to climate change, the compatibility of "governance-for-adaptation" with the current paradigms of public administration has generally been overlooked. Over the last several decades, countries around the globe have embraced variants of the philosophy of administration broadly called "New Public Management" (NPM) in an effort to improve administrative efficiencies and the provision of public services. Using evidence from a case study of reforms in the building sector in Norway, and a case study of water and flood risk management in central Mexico, we analyze the implications of the adoption of the tenets of NPM for adaptive capacity. Our cases illustrate that some of the key attributes associated with governance for adaptation—namely, technical and financial capacities; institutional memory, learning and knowledge; and participation and accountability—have been eroded by NPM reforms. Despite improvements in specific operational tasks of the public sector in each case, we show that the success of NPM reforms presumes the existence of core elements of governance that have often been found lacking, including solid institutional frameworks and accountability. Our analysis illustrates the importance of considering both longer-term adaptive capacities and short-term efficiency goals in public sector administration reform.

  3. Between the effectivity and affectivity: new teachers in times of new public management

    Directory of Open Access Journals (Sweden)

    Rodrigo Andres Soto Lagos

    2016-11-01

    Full Text Available The Educational Public Policy in the current neoliberal context hold their proposals under the New Public Management (NPM. These devices promote a professionalization of the teaching role, positioning them as responsible for changes in education in the country. This research focuses on the discourse analysis of twelve official documents of the Ministry of Education of Chile, which under the logic of NPM promote emotions and effectiveness to interpellate teachers and invite them to work in adverse conditions. The results shows two interpellations to teachers in the country, one that relates to the effectiveness, based on competition, and other centered in affections, both challenging teachers individually and emotional. It is discussed relative to the direction of public policy devices that are supported from the NPM.

  4. Assessment of new public management in health care: the French case.

    Science.gov (United States)

    Simonet, Daniel

    2014-10-06

    The French health care system embraced New Public Management (NPM) selectively, and crafted their own version of NPM using Diagnostic-Related-Group accounting to re-centralize the health care system. Other organizational changes include the adoption of quasi-markets, public private partnerships, and pay-for-performance schemes for General Practitioners. There is little evidence that these improved the performance of the system. Misrepresentation has remained high. With the 2009 Hospital, Patients, Health and Territories Act physician participation in hospital governance receded. Decision-making powers and health units were re-concentrated to instill greater national coherence into the health system.

  5. Managing Public Accountability : How Public Managers Manage Public Accountability

    NARCIS (Netherlands)

    Schillemans, Thomas

    2015-01-01

    Accountability is of growing importance in contemporary governance. The academic literature on public accountability is fraught with concerned analyses, suggesting that accountability is a problematic issue for public managers. This article investigates how public managers experience accountability

  6. Pseudo-quantities, New Public Management and Human Judgement

    Directory of Open Access Journals (Sweden)

    Sven-Eric Liedman

    2012-10-01

    and conscientious verbal evaluation. The term pseudo-quantity is new, but the phenomenon is well known to researchers and has become the subject of a rapidly growing stream of literature.1 The new term would primarily be intended to provide insight into the on-going mechanisms and processes that underlie this phenomenon. Furthermore, this term has a critical potential that is urgently needed at a time when many individuals erroneously believe that pseudoquantities can be used to gain both time and perspective. In the first part of the article, I will present the new concept and its background in the concepts of quality and quantity. The importance of this term is pertinent to the founding of New Public Management (NPM in the public sector. NPM will be treated in the following section. I will specifically highlight how this process influences education and research. In the conclusion, I summarise my argument and provide insight regarding a possible alternative.

  7. The promises and facts of emergent strategy in public management

    DEFF Research Database (Denmark)

    Aagaard, Peter

    Public managers are experiencing a growing demand for innovation. One of the promising approaches to instigating innovation is that of emergent strategic patterns (ESPs). According to the literature, the institutional barriers and drivers of ESPs are shaped by the two dominant public management...... models, NPM (the barriers) and governance (the drivers). However, based on an empirical case study of the institutional barriers and drivers for ESPs in the Danish Crime Prevention Council, this article concludes that ESPs are in fact enabled by a much more mixed management model....

  8. The promises and facts of emergent strategy in public management

    DEFF Research Database (Denmark)

    Aagaard, Peter

    Public managers are experiencing a growing demand for innovation. One of the promising approaches to instigating innovation is that of emergent strategic patterns (ESPs). According to the literature, the institutional barriers and drivers of ESPs are shaped by the two dominant public management m...... models, NPM (the barriers) and governance (the drivers). However, based on an empirical case study of the institutional barriers and drivers for ESPs in the Danish Crime Prevention Council, this article concludes that ESPs are in fact enabled by a much more mixed management model....

  9. Social capital practices as adaptive drivers for local adjustment of new public management in schools

    DEFF Research Database (Denmark)

    Olesen, Kristian Gylling; Hasle, Peter; Sørensen, Ole H.

    2016-01-01

    New public management (NPM) reforms have typically undermined teachers’ autonomy, values, and status in society. This article questions whether such reforms automatically have these outcomes or whether and how possibilities for local adjustment of such reforms may prevent negative outcomes. Drawing...

  10. Social Capital Practices as Adaptive Drivers for Local Adjustment of New Public Management in Schools

    Science.gov (United States)

    Olesen, Kristian Gylling; Hasle, Peter; Sørensen, Ole H.

    2016-01-01

    New public management (NPM) reforms have typically undermined teachers' autonomy, values, and status in society. This article questions whether such reforms automatically have these outcomes or whether and how possibilities for local adjustment of such reforms may prevent negative outcomes. Drawing on empirical case studies from two Danish…

  11. New Public Management and the New Professionalism in Education: Framing the Issue

    Science.gov (United States)

    Anderson, Gary; Herr, Kathryn

    2015-01-01

    This article provides an introductory frame for this special issue dedicated to New Public Management and the New Professional Educator. We will introduce the five articles and how they analyze the characteristics of NPM and this emerging new professional as well as forms of educator resistance and advocacy.

  12. Neoliberalism, New Public Management and the Sustainable Development Agenda of Higher Education: History, Contradictions and Synergies

    Science.gov (United States)

    Bessant, Sophie E. F.; Robinson, Zoe P.; Ormerod, R. Mark

    2015-01-01

    This paper explores the ideological and the practical relationship between neoliberalism and New Public Management (NPM) and the sustainable development agenda of western higher education. Using the United Kingdom and specifically English universities as an example, it investigates the contradictions and the synergies between neoliberal and NPM…

  13. Neoliberalism, New Public Management and the Sustainable Development Agenda of Higher Education: History, Contradictions and Synergies

    Science.gov (United States)

    Bessant, Sophie E. F.; Robinson, Zoe P.; Ormerod, R. Mark

    2015-01-01

    This paper explores the ideological and the practical relationship between neoliberalism and New Public Management (NPM) and the sustainable development agenda of western higher education. Using the United Kingdom and specifically English universities as an example, it investigates the contradictions and the synergies between neoliberal and NPM…

  14. After managerialism: MacIntyre's lessons for public administration.

    NARCIS (Netherlands)

    Overeem, P.

    2011-01-01

    Disappointing results and negative consequences of government reforms inspired by New Public Management (NPM) ideas have recently stimulated Public Administration scholars to develop alternative approaches to governance. Prominent alternatives in current debates are the Neo-Weberian State, Public Va

  15. Control and Autonomy—The SAIs in Norway, Denmark, and Germany as Watchdogs in an NPM-Era?

    DEFF Research Database (Denmark)

    Jantz, Bastian; Reichborn-Kjennerud, Kristin; Vrangbæk, Karsten

    2015-01-01

    New public management (NPM) reforms have weakened the direct steering capacity within state bureaucracy. This article looks into how supreme audit institutions in three countries (Norway, Denmark, and Germany) assess these types of reforms. The analysis shows that all three SAIs have taken...

  16. New public management and policies of secrecy

    Directory of Open Access Journals (Sweden)

    Lise DEMAILLY

    2013-12-01

    Full Text Available Crossing a survey of literature in sociology of health and her own inquiries in the field of mental health, the author studies the historical change in policies of secrecy in health domains and specifically, in modern democracies, practical aporias opposing rights and duties to and towards secrecy, rights and duty to and towards transparency. The paper describes weakening of medical secret regarding legitimization of standards of transparency, coordination and evaluation supported by the New Public Management (NPM. Two forms of resistance against technocratic enforcement to publicizing are suggested. The first of these forms is the historical exception, nowadays vilified as out of date, of psychoanalysis bound to strict secret of the singular interview and building there a space for emancipation, preventing any governance of behavior by healthiness. The second one: some intentional and paradoxical break of secret can result in symbolic reversal against domination and shame.

  17. The Introduction of New Public Management Principles in the Italian Public Sector

    Directory of Open Access Journals (Sweden)

    Marino CALOGERO

    2010-06-01

    Full Text Available Over the last few decades, the Italian public administration has undergone significant reform, which aimed to rectify the structural defects in the system, leading to inefficiency in public management and an improper allocation and utilization of resources. The Italian legislator, following the New Public Management (NPM guidelines, introduced private principles and instruments in the public field to improve the efficiency, effectiveness and financial stability of state enterprise. In particular, one of the main innovations introduced in this field regarded the recognition of the principle of distinction between politics and administration and the transfer from a bureaucratic model based on norms to a managerial model based on performance. The reform has the aim of changing the traditional “weberian bureaucratic” approach of the Italian public administration, in accordance with the NPM principles. This reform process regarded also other European countries that have undergone profound changes. As well as Italy, the reform process in these countries was based on the principles of NPM which proclaims: an increased focus on results in terms of efficiency, effectiveness and quality of service by setting standards of productivity; an orientation towards citizens-consumers in terms of service quality and customer satisfaction; the introduction of market mechanisms; a more strategic focus on the reinforcement of strategic capacity. This paper is underpinned by an analysis of the regulation introduced by the reform of the Italian public administration to observe whether its main objectives have been really achieved. It is also based on a comparative analysis of the effects produced by reforms in Italy and in other European Countries. Lastly this work aims to verify if it is possible to individuate a framework of convergence based on the principles of new public management.

  18. Hierarchy and Power: A Conceptual Analysis with Particular Reference to New Public Management Reforms in German Universities

    Science.gov (United States)

    Hüther, Otto; Krücken, Georg

    2013-01-01

    For more than 20 years, new public management (NPM) has been the guiding governance model of university reforms in Europe. One central aspect of this governance model is to strengthen the hierarchy within the universities. Recent research shows that the formal decision-making authority of university leaders and deans has increased in almost every…

  19. New Public Management as a Global Education Policy: Its Adoption and Re-Contextualization in a Southern European Setting

    Science.gov (United States)

    Verger, Antoni; Curran, Marta

    2014-01-01

    In the education sector, new public management (NPM) has crystallized in policies such as school autonomy, professionalization of school principals, standardized evaluation and teachers' accountability, and it has been widely disseminated by international organizations, such as the OECD, which enjoy a great prestige when it comes to frame…

  20. Hierarchy and Power: A Conceptual Analysis with Particular Reference to New Public Management Reforms in German Universities

    Science.gov (United States)

    Hüther, Otto; Krücken, Georg

    2013-01-01

    For more than 20 years, new public management (NPM) has been the guiding governance model of university reforms in Europe. One central aspect of this governance model is to strengthen the hierarchy within the universities. Recent research shows that the formal decision-making authority of university leaders and deans has increased in almost every…

  1. Effective Public Management

    Science.gov (United States)

    Bower, Joseph L.

    1977-01-01

    Argues that public management differs from private management not just in degree but in quality, so that American business is an inappropriate analogy for evaluating public management. In particular, "purpose,""organization," and "people" have different meaning and significance in public agencies and private businesses. (JG)

  2. Effective Public Management

    Science.gov (United States)

    Bower, Joseph L.

    1977-01-01

    Argues that public management differs from private management not just in degree but in quality, so that American business is an inappropriate analogy for evaluating public management. In particular, "purpose,""organization," and "people" have different meaning and significance in public agencies and private businesses. (JG)

  3. Assessment of management approaches in a public water utility: A case study of the Namibia water corporation (NAMWATER)

    Science.gov (United States)

    Ndokosho, Johnson; Hoko, Zvikomborero; Makurira, Hodson

    More than 90% of urban water supply and sanitation services in developing countries are provided by public organizations. However, public provision of services has been inherently inefficient. As a result a number of initiatives have emerged in recent years with a common goal to improve service delivery. In Namibia, the water sector reform resulted in the creation of a public utility called the Namibia Water Corporation (NAMWATER) which is responsible for bulk water supply countrywide. Since its inception in 1998, NAMWATER has been experiencing poor financial performance. This paper presents the findings of a case study that compared the management approaches of NAMWATER to the New Public Management (NPM) paradigm. The focus of the NPM approach is for the public water sector to mirror private sector methods of management so that public utilities can accrue the benefits of effectiveness, efficiency and flexibility often associated with private sector. The study tools used were a combination of literature review, interviews and questionnaires. It was found out that NAMWATER has a high degree of autonomy in its operations, albeit government approved tariffs and sourcing of external financing. The utility reports to government annually to account for results. The utility embraces a notion of good corporate culture and adheres to sound management practices. NAMWATER demonstrated a strong market-orientation indicated by the outsourcing of non-core functions but benchmarking was poorly done. NAMWATER’s customer-orientation is poor as evidenced by the lack of customer care facilities. NAMWATER’s senior management delegated operational authority to lower management to facilitate flexibility and eliminate bottlenecks. The lower management is in turn held accountable for performance by the senior management. There are no robust methods of ensuring sufficient accountability indicated by absence of performance contracts or service level agreements. It was concluded that

  4. Japanese University Reform--Hybridity in Governance and Management

    Science.gov (United States)

    Christensen, Tom

    2011-01-01

    University reforms around the world reflect many of the ideas and measures associated with the New Public Management (NPM) reform wave that emerged in Australia and New Zealand in the early 1980s. However, they also display features of the post-NPM reforms introduced in the last decade. In this article I focus on university reforms in Japan,…

  5. Strategic Planning and Public management Reform: The Case of Romania

    Directory of Open Access Journals (Sweden)

    Călin Emilian HINȚEA

    2015-12-01

    Full Text Available Strategic planning is an excellent tool that local governments can (and should use in order to deal effi ciently with change, which means that planning is an important aspect of public sector reform, arguably one of the defi ning elements of the public policy landscape for the past three decades (Pollitt and Bouckaert, 2011. Our main objective with this research is twofold: to analyze why and how local public administration uses strategic planning as a managerial tool for managing change (reform, and to identify whether the planning efforts display a specifi c reform pattern. We employed a quantitative methodology – online survey – to collect data on the strategic planning process at the local level in Romania, with a specifi c framework for the strategic profi le (Hinţea, 2015 and another three dimension model – NPM, NWS, NPG1 – for the reform component (Pollitt and Bouckaert, 2011. Our analysis indicates that over 70% of strategic planning efforts are done because it is a mandatory condition for accessing EU funds. Major issues concern implementation, monitoring and evaluation with only around a third of organizations having a formal body responsible for this. Although the process has mixed characteristics, NWS type elements are more common/preferred, while NPM seem least common/preferred by local authorities

  6. Policy, Profession and Public Management

    DEFF Research Database (Denmark)

    Kann-Christensen, Nanna; Balling, Gitte

    Introduction The aim of this paper is to contribute to the establishment of a theoretically based understanding of the role that cultural policy plays in the way literature promotion is practiced in Danish public libraries. More specifically we aim at refining a model that integrates different issues which...... of literature promotion and other activities in public libraries, but that cultural policy must be seen in some kind of interaction with the logics of profession and NPM. These interactions or relations are the key objects of analysis in this paper. Our research question therefore concerns how Cultural policy...... is usually understood through the concept of rationales. In two influential articles, Skot-Hansen has argued that cultural policy since the 1960s has developed from a humanistic rationale as the principal argument, over a sociological rationale to the emerging of an instrumental rationale in the 80s (Skot...

  7. Value-creation and networking in coopetition and public value management-The two challenging complementing frameworks of management studies

    Directory of Open Access Journals (Sweden)

    Teacher/lecturer Rauno Rusko

    2010-12-01

    Full Text Available Managerialism, emphasising on competition, is a leading penetrable practice or method in public and business management. However, managerialism is not a unique principle to manage public and private organisations. In this study we introduce, in addition to managerialism and its backgrounds, the challenging contemporary practices or paradigms of public and business management, such as cooperation, or simultaneous cooperation and competition, that is coopetition, and public value management (PVM, and show their practical and theoretical significance in the management discussions. Regardless of the possibility to dispute the existence of both coopetition paradigm because of the contemporary dominating competition and cooperation paradigms, and PVM because of the different versions of post NPM viewpoints, we introduce the complementary roles of coopetition and PVM frameworks for the management studies and practices

  8. NEW PUBLIC MANAGEMENT ELEMENTS IN ROMANIA’S PUBLIC SERVICES IN THE EUROPEAN CONTEXT

    Directory of Open Access Journals (Sweden)

    Moraru Marilena Ortansa

    2012-12-01

    Full Text Available New Public Management (NPM is considered as a global paradigm emerging in response to economic, institutional, political, and ideological changes.Many attempts to define the New Public Management have been made and there are several definitions of this notion, referring to the implementation of management ideas from business and private sector into the public services.Over the past few years, Romania has been facing a great challenge as it has to enhance its public management for achieving the European standards and values of transparency, predictability, accountability, adaptability and efficiency. The necessity of a modern administration at European standards exists both at the level of the citizen, and at the level of institutions delivering public services.According to the provisions of its last stand-by arrangement with IMF, Romania placed emphasis on restoring medium- and long-term sustainability and paved the way for future growth. Structural reforms were a large component of the program, including tax administration, pensions, public wages and employment, and social benefits, improving public sector efficiency, as well as enhancing the business environment.\\\\\\\\r\\\\\\\

  9. Stakeholders Involvement in Performance Management in Public General Schools

    Directory of Open Access Journals (Sweden)

    Kristi Ploom

    2013-01-01

    Full Text Available In response to increasing concerns with the legitimacy and efficiency of public spending, performance management as a part of world-wide public sector reform, called New Public Management (NPM has taken place. This is also the case of educational sector. In Estonian education system, legislation formally enables to design an integrated performance management system. But there is few research done to investigate how these policies and regulations ought to be put into force in order to gain the benefits considering the schools' and pupils' better performance. This study investigates how different stakeholders are involved into the performance management in Estonian general schools. The study is based on empirical survey data gathered from 303 schools providing secondary education in Estonia. The research findings have three main implications. Firstly, the paper contributes to the scarce knowledge about implementation of performance management issues in public schools. Our analysis revealed that compilation of school development plans in Estonian schools is rather a formal obligation. Therefore we propose that the analysis and discussion of the school development plans is needed to organize on regional level, involving all main stakeholders of a school. Secondly, we suggest that in the circumstances of a decentralised education system, like in Estonia, it is needed to implement, central practical performance assessment principles and guidance for the schools. Thirdly, it is highly necessary to improve schools’ cooperation with different stakeholder groups. Also the framework involving different stakeholder groups in the decentralized schools management system should be built up.

  10. Determining the contribution of NPM1 heterozygosity to NPM-ALK-induced lymphomagenesis.

    Science.gov (United States)

    Mduff, Fiona K E; Hook, C Elizabeth; Tooze, Reuben M; Huntly, Brian J; Pandolfi, Pier Paolo; Turner, Suzanne D

    2011-09-01

    Heterozygous expression of Nucleophosmin (NPM1) predisposes to hematological malignancies in the mouse and cooperates with Myc in lymphomagenesis. NPM1 is therefore regarded as a haploinsufficient tumor suppressor. Heterozygous loss of NPM1 occurs as a result of the t(2;5), which generates the oncogenic fusion tyrosine kinase, NPM-anaplastic lymphoma kinase (ALK), a molecule underlying the pathogenesis of anaplastic large cell lymphoma (ALCL). Given the aforementioned role of NPM1 as a tumor suppressor, we hypothesized that NPM1 heterozygosity would cooperate with NPM-ALK in lymphomagenesis. In the event, we observed no difference in tumor latency, incidence or phenotype in NPM-ALK-transgenic mice heterozygous for NPM1 relative to transgenic mice expressing both NPM1 alleles. We propose that although the t(2;5) simultaneously reduces NPM1 allelic dosage and creates the NPM-ALK fusion protein, the two events do not cooperate in the pathogenesis of ALCL in our mouse model. These data indicate that a tumor-suppressive role for NPM1 may depend on cellular and/or genetic context.

  11. Le New Public Management et la réforme de l'hôpital public en France avec la loi HPST

    OpenAIRE

    Ferguene, Améziane

    2014-01-01

    International audience; Le thème de la « modernisation de l’Etat » vise à améliorer les méthodes de gestion des grandes administrations (traditionnellement organisées sur le modèle de la bureaucratie wéberienne) : cette évolution vers un nouveau management public (« New Public Management », NPM) a initialement (début des années 1990) concerné les pays anglo-saxons et d’Europe du Nord (USA, Canada, Grande Bretagne, pays scandinaves) avant de toucher les pays d’Europe du Sud. En ce qui la conce...

  12. New Public Management or Mismanagement? The Case of Public Service Agency of Indonesia

    Directory of Open Access Journals (Sweden)

    JIN-WOOK CHOI

    2016-02-01

    Full Text Available In line with the new public management (NPM, a public service agency (PSA is considered as an alternative to replace the government-led public service delivery in a more efficient and effective way. At the same time, a PSA mechanism can deliver public service with better quality. To meet these ends, a PSA is granted with operational flexibility and autonomy particularly in managing finance and personnel. However, the PSA system has not yielded the expected benefits in Indonesia. On the contrary, PSAs have been regarded to cause financial burdens to the Government of Indonesia. This paper explores the current conditions of three key institutional bases of PSAs in Indonesia including PSA governance, financial management and performance management. The notable challenges related to the three dimensions in the Indonesia’s PSAs include the weak PSA governance structure, and an inappropriate balance between flexibility and autonomy on the one hand and accountability and performance on the other in managing a PSA. Focusing on these challenges, this paper draws the following policy suggestions for Indonesia to improve the efficient operation of the PSA system: rebuild the PSA governance on a firm and clear legal base, absorb diverse stakeholders and outside experts in the PSA governance decision-making; monitor and evaluate the PSA’s financial flexibility and autonomy through vigilant internal and external monitoring mechanisms; redesign performance appraisal to set up right appraisal structure, process, and performance criteria; and link the results of performance appraisal to relevant rewards and punishment.

  13. Public debt management

    Directory of Open Access Journals (Sweden)

    Stevan Gaber

    2013-07-01

    Full Text Available The paper generally describes the segment of public debt management or especially the structure of public debt. It focuses on different kinds of risks which present potential danger for the public debt explosion. It intends to explain the government goal for borrowing money at lowest rate and sustain the fiscal stability. Also, it explains some practical issues regarding this topic for Republic of Macedonia for the period from 2009-2011. In the process of research were implemented several qualitative methods.

  14. The New Public Managementis Not That Bad After All: Evidence From Estonia, Hungary and Romania

    Directory of Open Access Journals (Sweden)

    Sorin DAN

    2015-02-01

    Full Text Available This article reviews the New Public Man-agement (NPM literature in Central and Eastern Europe, looking particularly at reforms in Estonia, Hungary and Romania. It fnds that research that assessed changes in internal processes and ac-tivities within the public sector by far outnumber research that assessed changes in outputs and outcomes. Signifcant challenges in assessing impacts make sweeping claims about whether NPM ‘works’ diffcult to support with solid evi-dence. The paper shows that NPM policy is still considered as an option for public sector mod-ernization in Central and Eastern Europe, and suggests that a number of components of NPM, if not the model as a whole, are likely to contin-ue to exert infuence on the public sector in the future.

  15. The role of trust in public services and public sector reform

    NARCIS (Netherlands)

    S.G.J. Van de Walle (Steven)

    2013-01-01

    markdownabstract__Abstract__ The balance between trust and distrust is shifting – yet again. The move towards public sector reforms inspired by the New Public Management (NPM) from the 1980s on introduced a series of innovations based on mutual distrust between public sector actors. More

  16. The role of trust in public services and public sector reform

    NARCIS (Netherlands)

    S.G.J. Van de Walle (Steven)

    2013-01-01

    markdownabstract__Abstract__ The balance between trust and distrust is shifting – yet again. The move towards public sector reforms inspired by the New Public Management (NPM) from the 1980s on introduced a series of innovations based on mutual distrust between public sector actors. More recently,

  17. The pathobiology of the oncogenic tyrosine kinase NPM-ALK: a brief update.

    Science.gov (United States)

    Lai, Raymond; Ingham, Robert J

    2013-04-01

    Extensive research has been carried out in the past two decades to study the pathobiology of nucleophosmin-anaplastic lymphoma kinase (NPM-ALK), which is an oncogenic fusion protein found exclusively in a specific type of T-cell lymphoid malignancy, namely ALK-positive anaplastic large cell lymphoma. Results from these studies have provided highly useful insights into the mechanisms by which a constitutively tyrosine kinase, such as NPM-ALK, promotes tumorigenesis. Several previous publications have comprehensively summarized the advances in this field. In this review, we provide readers with a brief update on specific areas of NPM-ALK pathobiology. In the first part, the NPM-ALK/signal transducer and activator of transcription 3 (STAT3) signaling axis is discussed, with an emphasis on the existence of multiple biochemical defects that have been shown to amplify the oncogenic effects of this signaling axis. Specifically, findings regarding JAK3, SHP1 and the stimulatory effects of several cytokines including interleukin (IL)-9, IL-21 and IL-22 are summarized. New concepts stemming from recent observations regarding the functional interactions among the NPM-ALK/STAT3 axis, β catenin and glycogen synthase kinase 3β will be postulated. Lastly, new mechanisms by which the NPM-ALK/STAT3 axis promotes tumorigenesis, such as its modulations of Twist1, hypoxia-induced factor 1α, CD274, will be described. In the second part, we summarize recent data generated by mass spectrometry studies of NPM-ALK, and use MSH2 and heat shock proteins as examples to illustrate the use of mass spectrometry data in stimulating new research in this field. In the third part, the evolving field of microRNA in the context of NPM-ALK biology is discussed.

  18. Immunohistochemistry predicts nucleophosmin (NPM) mutations in acute myeloid leukemia.

    Science.gov (United States)

    Falini, Brunangelo; Martelli, Maria Paola; Bolli, Niccolò; Bonasso, Rossella; Ghia, Emanuela; Pallotta, Maria Teresa; Diverio, Daniela; Nicoletti, Ildo; Pacini, Roberta; Tabarrini, Alessia; Galletti, Barbara Verducci; Mannucci, Roberta; Roti, Giovanni; Rosati, Roberto; Specchia, Giorgina; Liso, Arcangelo; Tiacci, Enrico; Alcalay, Myriam; Luzi, Lucilla; Volorio, Sara; Bernard, Loris; Guarini, Anna; Amadori, Sergio; Mandelli, Franco; Pane, Fabrizio; Lo-Coco, Francesco; Saglio, Giuseppe; Pelicci, Pier-Giuseppe; Martelli, Massimo F; Mecucci, Cristina

    2006-09-15

    Nucleophosmin (NPM) exon-12 mutations occur in 50% to 60% of adult acute myeloid leukemia (AML) with normal karyotype and are predictors of favorable prognosis. We evaluated bone marrow or peripheral blood samples from 450 adult patients with AML of the GIMEMA (Gruppo Italiano Malattie Ematologiche Maligne dell'Adulto)/AML12 EORTC (European Organization for Research and Treatment of Cancer) trial to (1) search for new exon-12 NPM mutations; (2) determine whether NPM immunostaining on paraffin-embedded biopsies predicts NPM mutations; and (3) investigate altered nucleocytoplasmic NPM traffic in primary AML cells. Fourteen NPM mutations, including 8 new variants, were identified. All 200 AML cases expressing cytoplasmic NPM (NPMc(+) AML) carried NPM mutations. None of the 250 cases with nucleus-restricted NPM (NPMc(-) AML) was mutated. At the C-terminus, NPM leukemic mutants carried mutations of only tryptophan 290 or of both tryptophans 288 and 290 and a new nuclear export signal (NES) motif, which appear to underlie their nuclear export. The specific Crm1/exportin-1 inhibitor leptomycin-B relocated NPM mutants from cytoplasm to nucleus of primary NPMc(+) AML cells, demonstrating that nuclear export is NES dependent. NPM mutants bound and recruited wild-type NPM into leukemic cell cytoplasm. Because alterations at C-terminus of leukemic NPM mutants are similar, immunohistochemistry detects all exon-12 NPM mutations and is a valuable, inexpensive tool in the diagnostic-prognostic work-up of patients with AML with normal karyotype.

  19. Legitimation as a particular mode of strategic communication in the public sector

    DEFF Research Database (Denmark)

    Aggerholm, Helle Kryger; Thomsen, Christa

    2016-01-01

    ) reforms in a public sector organization. The context of NPM in the case study is particularly relevant for our investigation, because it sets the stage for the creation of legitimation by the public sector managers. Our analysis finds that these public sector managers use the integration of ‘voices...

  20. After the reform : Change in Dutch public and private organizations

    NARCIS (Netherlands)

    Nieto Morales, F.; Wittek, R.P.M.; Heyse, L.

    Proponents of new public management (NPM) expect public organizations to become more flexible and adaptive after administrative reforms, effectively showing convergence with patterns of organizational change in the private sector. This "convergence argument" is tested with a sample of 61 public and

  1. State and Executive Perceptions of Public Sector Reform in Europe.

    NARCIS (Netherlands)

    D.S.D. Curry; G. Hammerschmid (Gerhard); S.R. Jilke (Sebastian); S.G.J. Van de Walle (Steven)

    2015-01-01

    markdownabstract__Abstract__ Like most other areas of the world, the public sector in Europe has undergone significant reform in the past two decades, shaped in part by a broader New Public Management (NPM) paradigm, but one that also introduces a unique European flavour to this form of public mana

  2. After the reform : Change in Dutch public and private organizations

    NARCIS (Netherlands)

    Nieto Morales, F.; Wittek, R.P.M.; Heyse, L.

    2013-01-01

    Proponents of new public management (NPM) expect public organizations to become more flexible and adaptive after administrative reforms, effectively showing convergence with patterns of organizational change in the private sector. This "convergence argument" is tested with a sample of 61 public and

  3. SUMOylation Confers Posttranslational Stability on NPM-ALK Oncogenic Protein

    Directory of Open Access Journals (Sweden)

    Deeksha Vishwamitra

    2015-09-01

    Full Text Available Nucleophosmin-anaplastic lymphoma kinase–expressing (NPM-ALK+ T-cell lymphoma is an aggressive form of cancer that commonly affects children and adolescents. The expression of NPM-ALK chimeric oncogene results from the chromosomal translocation t(2;5(p23;q35 that causes the fusion of the ALK and NPM genes. This translocation generates the NPM-ALK protein tyrosine kinase that forms the constitutively activated NPM-ALK/NPM-ALK homodimers. In addition, NPM-ALK is structurally associated with wild-type NPM to form NPM/NPM-ALK heterodimers, which can translocate to the nucleus. The mechanisms that sustain the stability of NPM-ALK are not fully understood. SUMOylation is a posttranslational modification that is characterized by the reversible conjugation of small ubiquitin-like modifiers (SUMOs with target proteins. SUMO competes with ubiquitin for substrate binding and therefore, SUMOylation is believed to protect target proteins from proteasomal degradation. Moreover, SUMOylation contributes to the subcellular distribution of target proteins. Herein, we found that the SUMOylation pathway is deregulated in NPM-ALK+ T-cell lymphoma cell lines and primary lymphoma tumors from patients. We also identified Lys24 and Lys32 within the NPM domain as the sites where NPM-ALK conjugates with SUMO-1 and SUMO-3. Importantly, antagonizing SUMOylation by the SENP1 protease decreased the accumulation of NPM-ALK and suppressed lymphoma cell viability, proliferation, and anchorage-independent colony formation. One possible mechanism for the SENP1-mediated decrease in NPM-ALK levels was the increase in NPM-ALK association with ubiquitin, which facilitates its degradation. Our findings propose a model in which aberrancies in SUMOylation contribute to the pathogenesis of NPM-ALK+ T-cell lymphoma. Unraveling such pathogenic mechanisms may lead to devising novel strategies to eliminate this aggressive neoplasm.

  4. SUMOylation Confers Posttranslational Stability on NPM-ALK Oncogenic Protein.

    Science.gov (United States)

    Vishwamitra, Deeksha; Curry, Choladda V; Shi, Ping; Alkan, Serhan; Amin, Hesham M

    2015-09-01

    Nucleophosmin-anaplastic lymphoma kinase-expressing (NPM-ALK+) T-cell lymphoma is an aggressive form of cancer that commonly affects children and adolescents. The expression of NPM-ALK chimeric oncogene results from the chromosomal translocation t(2;5)(p23;q35) that causes the fusion of the ALK and NPM genes. This translocation generates the NPM-ALK protein tyrosine kinase that forms the constitutively activated NPM-ALK/NPM-ALK homodimers. In addition, NPM-ALK is structurally associated with wild-type NPM to form NPM/NPM-ALK heterodimers, which can translocate to the nucleus. The mechanisms that sustain the stability of NPM-ALK are not fully understood. SUMOylation is a posttranslational modification that is characterized by the reversible conjugation of small ubiquitin-like modifiers (SUMOs) with target proteins. SUMO competes with ubiquitin for substrate binding and therefore, SUMOylation is believed to protect target proteins from proteasomal degradation. Moreover, SUMOylation contributes to the subcellular distribution of target proteins. Herein, we found that the SUMOylation pathway is deregulated in NPM-ALK+ T-cell lymphoma cell lines and primary lymphoma tumors from patients. We also identified Lys24 and Lys32 within the NPM domain as the sites where NPM-ALK conjugates with SUMO-1 and SUMO-3. Importantly, antagonizing SUMOylation by the SENP1 protease decreased the accumulation of NPM-ALK and suppressed lymphoma cell viability, proliferation, and anchorage-independent colony formation. One possible mechanism for the SENP1-mediated decrease in NPM-ALK levels was the increase in NPM-ALK association with ubiquitin, which facilitates its degradation. Our findings propose a model in which aberrancies in SUMOylation contribute to the pathogenesis of NPM-ALK+ T-cell lymphoma. Unraveling such pathogenic mechanisms may lead to devising novel strategies to eliminate this aggressive neoplasm.

  5. Public Managers Should Be Proactive

    Science.gov (United States)

    Carlson, Thomas S.

    1976-01-01

    Future public managers should be proactive by creating management processes before problems arise. Planning prevents reactive or crisis managing. Future managers should also be prepared to meet dilemmas and paradoxes such as centralization versus decentralization of decision-making and work processes, politics versus administration dichotomy, and…

  6. La réceptivité culturelle des organisations du pouvoir judiciaire au management public : Perceptions et attentes des parties prenantes d'une « bonne justice » de première et seconde instance en Suisse, et implications managériales.

    OpenAIRE

    De Santis, L. G.

    2016-01-01

    Nous traitons dans ce travail de thèse de la réceptivité culturelle des organisations du pouvoir judiciaire au management public. Nous utilisons comme acception réduite du management public, le NPM, celui-ci étant certainement la forme la plus radicale du management public. En d'autres termes, nous essayons d'évaluer si les organisations, soit les tribunaux, qui composent l'institution judiciaire de première et seconde instance en Suisse sont ouvertes au management public et à ses valeurs et,...

  7. How does the NPM1 mutant induce leukemia?

    Directory of Open Access Journals (Sweden)

    Paolo Sportoletti

    2011-06-01

    Full Text Available NPM1 is the most frequently mutated gene in AML and the role of the NPM1 mutant in acute myeloid leukemia along with its leukemogenic potential are still under investigation. NPM1 genetic alterations can contribute to leukemogenesis through the direct oncogenic effect of the mutant protein and the concomitant loss of one functional allele. Npm1 loss determines tumor development in the mouse while in human NPM1 maps in a chromosomal region frequently loss in myelodysplastic syndrome (MDS. The NPM1 mutant cytoplasmic delocalization in leukemic blasts alters multiple cellular pathways through either loss or gain of function effects on different protein partners. Here we discuss the most relevant studies on the role of the NPM1 molecule in hematological malignancies and both in vitro and in vivo studies that are trying to elucidate the way by which the NPM1 mutation induces leukemia.

  8. Public Sector Expatriate Managers:

    DEFF Research Database (Denmark)

    Fenner, Charles, R., Jr.; Selmer, Jan

    2008-01-01

    Although public sector expatriates are becoming increasingly common, research on them is very limited. There is reason to believe that the situation for expatriates from the public sector may be different than for those from the private sector. This study investigated U.S. Department of Defense a...

  9. Kritikken af new public management er forfejlet

    DEFF Research Database (Denmark)

    Klausen, Kurt Klaudi

    2016-01-01

    kronikken adresserer og korrigerer den opfattelse at de nyliberalistiske reformer under betegnelsen NPM ikke har bidraget positivt til moderniseringen af den offentlige sektor.......kronikken adresserer og korrigerer den opfattelse at de nyliberalistiske reformer under betegnelsen NPM ikke har bidraget positivt til moderniseringen af den offentlige sektor....

  10. Romanians Civil Servants between New Public Management and Neo Weberian Principles. Some perspectives

    Directory of Open Access Journals (Sweden)

    Ana-Maria Bercu

    2012-02-01

    Full Text Available This paper aims at outlining the contents of the special issue on Romanian civil servants,making a comparative analyze of the principles applicable: can we discuss about New PublicManagement (NPM approaches or, taking into consideration the Romanian civil service reform, wehave a Neo Weberian model? The article provides reviews of the scientific literatures in this specialissue. The argument is that the work performance ofcivil servants are based on a set of goalsdetermined by the citizens-clients needs and the market movements, but, in the mean time, it is aboutthe quality of work in terms of citizens satisfaction and the innovative solutions for the administrativeproblems. The special issue, of which this articleprovides an overview, make an incursion in theliterature providing analyze on the Romanians civilservants based on the steps of actual reform andputting on the questions the managerial and bureaucratic principles. Research limitations include thewidth of the phenomenon under discussion. We statethat the work and performance means not onlyNPM principles, but have instead chosen to adopt the Neo Weberian approach.

  11. Small Public Library Management

    Science.gov (United States)

    Pearlmutter, Jane; Nelson, Paul

    2012-01-01

    Anyone at the helm of a small public library knows that every little detail counts. But juggling the responsibilities that are part and parcel of the job is far from easy. Finally, here's a handbook that includes everything administrators need to keep a handle on library operations, freeing them up to streamline and improve how the organization…

  12. Managing Public School Dollars.

    Science.gov (United States)

    American Inst. of Certified Public Accountants, New York, NY.

    Although this booklet focuses on methods of accumulating and analyzing management and the financial and statistical data helpful to members of school boards, equal emphasis is placed on meeting the needs of the pupil--making him more self confident, developing his skills, instilling knowledge, and inspiring creativity. It considers changes in the…

  13. T.R. – Journal of Organizational Change Management

    NARCIS (Netherlands)

    D Pick (David); S.T.T. Teo (Stephen); L.G. Tummers (Lars); C. Newton (Cameron)

    2013-01-01

    textabstractNew public management (NPM) refers to an ideology that underpinned public sector reform of the 1980s and 1990s (Dieffenbach, 2009; Hood, 1991; Pollitt & Bouckaert, 2004; 2011). At its core was a problematisation of existing public sector institutional forms and operations for which the s

  14. Lick Northern Proper Motion Program. III. Lick NPM2 Catalog

    Science.gov (United States)

    Hanson, Robert B.; Klemola, Arnold R.; Jones, Burton F.; Monet, David G.

    2004-09-01

    The Lick Northern Proper Motion (NPM) program, a two-epoch (1947-1988) photographic survey of the northern two-thirds of the sky (δ>~-23deg), has measured absolute proper motions, on an inertial system defined by distant galaxies, for 378,360 stars in the magnitude range 8NPM1 Catalog contains 148,940 stars in 899 fields outside the Milky Way's zone of avoidance. The 2003 NPM2 Catalog contains 232,062 stars in the remaining 347 NPM fields near the plane of the Milky Way. This paper describes the NPM2 star selection, plate measurements, astrometric and photometric data reductions, and catalog compilation. The NPM2 Catalog contains 122,806 faint (B>=14) anonymous stars for astrometry and Galactic studies, 91,648 bright (BNPM2 proper motions are on the ICRS system, via Tycho-2 stars, to an accuracy of 0.6 mas yr-1 in each field. The rms proper-motion precision is 6 mas yr-1. Positional errors average 80 mas at the mean plate epoch 1968, and 200 mas at the NPM2 catalog epoch 2000. NPM2 photographic photometry errors average 0.18 mag in B and 0.20 mag in B-V. The NPM2 Catalog and the updated (to J2000.0) NPM1 Catalog are available at the CDS Strasbourg data center and on the NPM Web site. The NPM2 Catalog completes the Lick Northern Proper Motion program after a half-century of work by three generations of Lick Observatory astronomers. The NPM Catalogs will serve as a database for research in Galactic structure, stellar kinematics, and astrometry.

  15. How is the New Public Management applied in the occupational health care system? - decision-makers' and OH personnel's views in Finland

    Directory of Open Access Journals (Sweden)

    Rissanen Sari

    2011-08-01

    Full Text Available Abstract Background In many countries occupational health care system is in change. Occupational health studies are mainly focused on occupational health substance and content. This study offers new perspectives on municipal OHS and its operations from management perspective. Aim The aim of this study is to analyse how New Public Management (NPM doctrines are applied in the Finnish occupational health care system (OHS. The main focus is to describe and compare the views of decision-makers' and OH workers within the framework of NPM. Methods The data were collected by semi-structured interviews from 17 municipal decision-makers' and 26 municipal OH workers. Data was analyzed by examining coded data in a theory-driven way according to Hood's doctrine of NPM. Results The doctrines were not as compatible with the OH personnel view as with the decision-makers' view. Decision-makers and OH personnel highlighted the strict criteria required for operation evaluation. Moreover, decision-makers strongly accentuated professional management in the public sector and the reorganization of public sector units. These were not equally relevant in OH personnel views. In OH personnel views, other doctrines (more attention to performance and accomplishments, emphasizing and augmentation of the competition and better control of public expense and means test were not similarly in evidence, only weak evidence was observed when their importance viewed as medium by decision-makers. Neither of the respondents group kept the doctrine of management models of the private sector relevant. Conclusions The NPM and Hoods doctrine fitted well with OH research. The doctrine brought out view differences and similarities between decision-makers and OH personnel. For example, policymakers highlighted more strongly the structural change by emphasizing professional management compared to OH personnel. The need for reorganization of municipal OH, regardless of different operational

  16. Communicating with external publics: managing public opinion and behavior.

    Science.gov (United States)

    Ristino, Robert J

    2007-01-01

    In health care organizational settings public relations plays an important role in managing relationships with a variety of external publics as well as with society in general. Managing these relationships involves both reactive and proactive communication activities. Reactively, public relations responds to public issues, crises and concerns, as well as inquiries from the media and other social institutions. Proactively, public relations engages in deliberately planned campaigns and programs to inform, influence or change behaviors of targeted publics for a wide range of strategic purposes. These purposes include managing the organization's image and identity; influencing public policies; supporting health promotion and education; promoting fund raising and volunteerism; and managing organizational change and crises.

  17. Antecedents of Public Performance Management

    DEFF Research Database (Denmark)

    Hansen, Morten Balle; Høgedahl, Laust Kristian; Opstrup, Niels

    of the organization and the hierarchical level of the manager as well as the gender and education background of the manager has some significant impact on the perceived utility of the PM system, although the relations are rather weak. We discuss our findings and their implications for PM theory, PM practice as well......In this paper the antecedents of Public Performance Management systems (PPMs) are analyzed. We explore the notion that the challenges and utility of public PM systems varies considerably due to a number of contingencies. We explore how various contingencies presumed to influence the use and utility...... on performance, the extent to which incentives where related to performance indicators and the problem of measuring performance of inter-organizational cooperation. Using descriptive statistics and multivariate regression analysis our preliminary findings indicate that both the functional tasks...

  18. Lick Northern Proper Motion Program. III. Lick NPM2 Catalog

    CERN Document Server

    Hanson, R B; Jones, B F; Monet, D G; Hanson, Robert B.; Klemola, Arnold R.; Jones, Burton F.; Monet, David G.

    2004-01-01

    The Lick Northern Proper Motion (NPM) program, a two-epoch (1947-1988) photographic survey of the northern two-thirds of the sky (Dec. > -23 deg), has measured absolute proper motions, on an inertial system defined by distant galaxies, for 380,000 stars from 8 14) anonymous stars for astrometry and galactic studies, 92,000 bright (B < 14) positional reference stars, and 35,000 special stars chosen for astrophysical interest. The NPM2 proper motions are on the ICRS system, via Tycho-2 stars, to an accuracy of 0.5 mas/yr in each field. RMS proper motion precision is 6 mas/yr. Positional errors average 80 mas at the mean plate epoch 1968, and 200 mas at the NPM2 catalog epoch 2000. NPM2 photographic photometry errors average 0.18 mag in B, and 0.20 mag in B-V. The NPM2 Catalog and the updated (to J2000) NPM1 Catalog are available at the CDS Strasbourg data center and on the NPM WWW site (http://www.ucolick.org/~npm). The NPM2 Catalog completes the Lick Northern Proper Motion program after a half-century of w...

  19. Servers training the Ministry of Public Rondônia State accounts as management strategy

    Directory of Open Access Journals (Sweden)

    Angelina Maria de Oliveira Licório

    2015-06-01

    Full Text Available This paper studies the relevance of training in public management from the assumptions of Managerial Administration where there is a causal link between personal capacitation and successfull performed services. This form also known as the New Public Management (NPM, aims at the quality of public services provided to citizens, availing itself for much of performance controls. In this context, the paper aims to verify the relevance of the training process conducted by the Rondônia’s Ministry of Public Accounts servers and reflections of training in improving the quality of services performed. Making use of the deductive method of research, we analyze aspects of capacitation in general, to understand its importance within the new model of public administration. As objective the research is classified as descriptive and as to approach the problem, qualitative. The research instrument drew on secondary sources and two questionnaires, one applied to advisers and assistants to cabinet and other Attorneys Auditors. The study concluded that there is a high level of participation in the training offered by the institution studied and that the majority of respondents believes that training has a direct and immediate impact on the services performed.

  20. Towards Efficient Public Sector Asset Management

    Directory of Open Access Journals (Sweden)

    Mihaela Grubišić

    2009-09-01

    Full Text Available Governments are accountable for providing quality public services to their citizens at the most favourable terms. They are, among other issues, responsible for managing a diversified public asset portfolio.This paper examines one of the critical financial challenges in Croatia: managing public sector assets efficiently. It attempts to facilitate better understanding of public asset management as an integral part of public sector reforms. The lack of reliable information on public assets in place hinders determination of the assets’value, budgeting for asset management activities and evaluating public asset portfolio performance. As a result, assets are managed on an ad-hoc, often reactive basis. Starting from the concept that public authorities have to be fully accountable to the public, we propose the preconditions necessary for commencing proper public asset management practice in Croatia. Our model might help other countries that are also faced with public asset management inefficiency.

  1. [Physicians see both pros and cons of health care financial management. Questionnaire study provides more insights--with starting point in controversial DN-article series].

    Science.gov (United States)

    Björk, Joar; Petersson, Christer

    2015-05-12

    In the spring of 2013, the Swedish journalist Maciej Zaremba wrote a series of articles criticizing the impact of NPM (New Public Management) on Swedish health care. The present study examines the views of experienced Swedish physicians (general practitioners and internal medicine speclialists) on the problems focused in Mr Zaremba's article series. The respondents (51 general practitioners and 61 internal medicine specialists) mention advantages as well as disadvantages with NPM in Swedish health care. The majority agrees that with NPM, physicians loose influence over health care governance to other professional groups. The majority disagree with the charge made by Mr Zaremba that NPM has had the effect of manipulating Swedish physicians away from the standards of good medical care.

  2. Crisis - Strategic Management in Public Relation

    OpenAIRE

    Saari Ahmad

    2012-01-01

    This is a concept paper to explore the strategic management approaches in public relations during crisis. The main objective of this article is to identify the most effective action plan for Public relation. The review of the strategic management in public relations literature reveals that the relationship between strategic management and public relations is still vague. Four stages were identified in the process of establishing the action plan for public relations and eleven strategic action...

  3. Legitimation as a particular mode of strategic communication in the public sector

    DEFF Research Database (Denmark)

    Aggerholm, Helle Kryger; Thomsen, Christa

    2016-01-01

    Within the theoretical frameworks of strategic communication and legitimation and through the use of a case study analysis, this article investigates the creation of managerial legitimation towards internal stakeholders in text and talk as a particular mode of strategic communication in a public...... sector organization. Following a theoretical discussion of the interconnectedness of strategic communication and managerial legitimation, we present a case study analysis of management talk at three interrelated management meetings dealing with the implementation of New Public Management-based (NPM......) reforms in a public sector organization. The context of NPM in the case study is particularly relevant for our investigation, because it sets the stage for the creation of legitimation by the public sector managers. Our analysis finds that these public sector managers use the integration of ‘voices...

  4. An Analysis of Business Models in Public Service Platforms

    DEFF Research Database (Denmark)

    Ranerup, Agneta; Zinner Henriksen, Helle; Hedman, Jonas

    2016-01-01

    Public Service Platforms (PSPs) are a new type of technology platform. They are based in the philosophy of New Public Management (NPM) and support public services for citizens in quasi-markets. This article increases our understanding of the business models behind these PSPs in terms of their Value...... Propositions, structures, networks, and financing. We interviewed representatives from 14 PSP providers in four public sectors in Sweden: education, healthcare, elder care, and public pensions. We identified a “Traditional view” with its focus on public agencies and neutral information and an “Emerging view......” that includes dialogues, user evaluations, long-term perspectives on choice, promotion of the ideal of choice, and self-promotion by public agencies. The article contributes to research with its empirical example of the digitalization of NPM and the underlying business logic of PSPs....

  5. 75 FR 146 - Public Comment on Candidate National Enforcement and Compliance Assurance Priorities for Fiscal...

    Science.gov (United States)

    2010-01-04

    ... environmental laws. EPA issues National Program Manager Guidance (NPM Guidance) so that EPA and states can effectively align their activities to achieve mutual goals. The NPM guidance must be released for state...

  6. Public Sector Reforms: New Public Management without Marketization?

    DEFF Research Database (Denmark)

    Löfgren, Karl; Pedersen, John Storm

    2012-01-01

    Is it possible to imagine New Public Management without marketization? In Denmark the present liberal-conservative Government has, throughout its 10 years in power, designed and implemented more than 15 major management reforms in the public sector. Although most of the reforms are rhetorically...

  7. Fra New Public Management til New Public Governance

    DEFF Research Database (Denmark)

    2017-01-01

    Konturerne i New Public Governance ikke er skarpt optegnede og dets gennemslag i praksis er uforudsigelig. I dette kapitel sættes New Public Governance i relation til New Public Management og kravet om evidensbasering af offentlige ydelser. Samskabelse præsenteres som nyt centralt begreb....

  8. Mutual Regulation of FOXM1, NPM and ARF Proteins.

    Science.gov (United States)

    Pandit, Bulbul; Gartel, Andrei L

    2015-01-01

    ARF, NPM and FOXM1 proteins interact with each other in mammalian cells. We showed previously that proteasome inhibitors suppress not only FOXM1 expression, but also the expression of ARF and NPM proteins. Using RNA interference we found that the depletion of each of these proteins by RNAi in human cancer HeLa cells leads to down-regulation of the two other partners, suggesting that these proteins stabilize each other in human cancer cells. Since the suppression of FOXM1 is one of hallmarks of proteasome inhibition, suppression of ARF and NPM by proteasome inhibitors may be explained in part as a secondary effect of downregulation of FOXM1 that modulate stability of ARF and NPM1 proteins.

  9. Managing complex systems: performance management in public health.

    Science.gov (United States)

    Landrum, Laura B; Baker, Stacy L

    2004-01-01

    The complexity of mobilizing and managing systems-wide public health responses has prompted Turning Point's Performance Management National Excellence Collaborative, funded by the Robert Wood Johnson Foundation, to develop a conceptual framework for performance management in public health. The framework has four integrated parts: (1) performance standards, (2) performance measures, (3) reporting of progress, and (4) a quality improvement process. The Collaborative based its framework on evidence gathered through a survey of current state performance management practices, a literature review, and its investigation of current practice models. This balanced and cohesive management model can be constructively used by public health programs, organizations, and community and state public health systems.

  10. Management Methods of Decentralized Public Services

    Directory of Open Access Journals (Sweden)

    BILOUSEAC Irina Adriana

    2013-05-01

    Full Text Available The purpose of the article, having as theme the typology of public services management and the implications on decentralization, is the foundation of theoretical concepts, but also the analysis from a practical point of view of both types of management applied in the management of public services in Romania and of the effects they cause on the Romanian public administration capacity to provide efficient public services. Although the users of decentralized public services don’t have the possibility of choosing the service provider, the analysis of the management methods is important, because depending on the type of management chosen there are advantages and disadvantages for the local community. It has to be analyzed for each particularly case which type of management leads to a greater satisfaction of a social need appeared.

  11. STRATEGIC MANAGEMENT IN NONPROFIT AND PUBLIC ORGANIZATIONS

    Directory of Open Access Journals (Sweden)

    Ioan NICOLAE

    2008-01-01

    Full Text Available Strategic management in public organizations can use coerciveness as a keyelement of their strategy. Private organizations are more dependent onmarketing or selling to potential customers. As publicness increases,marketing declines in importance and maintaining favorable coercivearrangements increases in importance. Strategic managers should be awareof coercive opportunities in their mandates as they fashion strategy anddevise implementation plans.

  12. Motivating the Private vs. Public Sector Managers.

    Science.gov (United States)

    Khojasteh, Mak

    1993-01-01

    A questionnaire on intrinsic/extrinsic rewards received 362 responses from 380 managers. Pay and security were greater motivators for private than for public sector managers. Recognition had higher motivating potential in the public sector. Both groups were motivated by achievement and advancement. (SK)

  13. Mechanisms of Change in Public Management Projects

    OpenAIRE

    Tiina Soininen

    2013-01-01

    This article draws conclusions from four separate case evaluations from different development programs in Finland and aims to discuss the role of welfare state values in new public management. The study develops a comprehensive picture of the change in public management since 2000. The synthesis of the four case studies follows the critical realism tradition. This article shows that cooperation forms the key mechanism ...

  14. OUTILS DE GESTION ET SERVICES PUBLICS : LE CAS DE LA COMPTABILITE ANALYTIQUE A L'UNIVERSITE

    OpenAIRE

    Anne, Martin

    2015-01-01

    International audience; This research is about implementation of a management accounting tool in a French university, analyzed through Actor-Network Theory (ANT). This tool is a compulsory constraint operationalizing the New Public Management trend (NPM) contented in the current public reform. To do this, a case study was conducted in a university, and the results show that an actant coming from context and history of the organization had a leading influence on the tool’s shape.; Cette recher...

  15. NPM-RAR, not the RAR-NPM reciprocal t(5;17)(q35;q21) acute promyelocytic leukemia fusion protein, inhibits myeloid differentiation.

    Science.gov (United States)

    Pollock, Sheri L; Rush, Elizabeth A; Redner, Robert L

    2014-06-01

    The t(5;17) variant of acute promyelocytic leukemia (APL) fuses the nucleophosmin (NPM) gene at 5q35 with the retinoic acid receptor alpha (RARA) at 17q12-22. We have previously shown that leukemic cells express both NPM-RAR and RAR- NPM reciprocal translocation products. In this study we investigated the potential role of both proteins in modulating myeloid differentiation. Expression of NPM-RAR inhibited vitamin D3/transforming growth factor β (TGFβ)-mediated differentiation of U937 cells by more than 50%. In contrast, RAR-NPM expression did not alter vitamin D3/TGFβ-induced differentiation of U937 clones. These results indicate that NPM-RAR, not RAR-NPM, is the prime mediator of myeloid differentiation arrest in t(5;17) APL.

  16. New Public Management and Education

    Science.gov (United States)

    Tolofari, Sowaribi

    2005-01-01

    Public administration has always been under constant review. Such reviews were mostly parochial, incremental, initiated or driven by low-key staff and often ended as fads. From the end of the 1970s to the 1990s, however, governments around the world were engaged in widespread and sustained reforms of their public administration. These reforms were…

  17. PUBLIC DEBT MANAGEMENT – FUNDAMENTAL COMPONENT OF PUBLIC POLICY

    Directory of Open Access Journals (Sweden)

    Maria Pascal (Andriescu

    2011-12-01

    Full Text Available The global financial crisis has put considerable pressure on public finances, particularly on government debt. Public debt in many countries of the world have increased in recent years to levels that were not registered by the end of the Second World War, facing today with a high risk regarding fiscal sustainability.Debt portfolio is usually the largest financial portfolio of a state, with a complex structure that can generate high risks that may affect public balance and financial stability of the country. Thus, proper management of public debt must become a priority for both the creditor and debtor countries. This paper aims to highlight the importance of effective management of government debt and to make a brief assessment of Romania's public debt structure and dynamic.

  18. Benchmarking management practices in Australian public healthcare.

    Science.gov (United States)

    Agarwal, Renu; Green, Roy; Agarwal, Neeru; Randhawa, Krithika

    2016-01-01

    The purpose of this paper is to investigate the quality of management practices of public hospitals in the Australian healthcare system, specifically those in the state-managed health systems of Queensland and New South Wales (NSW). Further, the authors assess the management practices of Queensland and NSW public hospitals jointly and globally benchmark against those in the health systems of seven other countries, namely, USA, UK, Sweden, France, Germany, Italy and Canada. In this study, the authors adapt the unique and globally deployed Bloom et al. (2009) survey instrument that uses a "double blind, double scored" methodology and an interview-based scoring grid to measure and internationally benchmark the management practices in Queensland and NSW public hospitals based on 21 management dimensions across four broad areas of management - operations, performance monitoring, targets and people management. The findings reveal the areas of strength and potential areas of improvement in the Queensland and NSW Health hospital management practices when compared with public hospitals in seven countries, namely, USA, UK, Sweden, France, Germany, Italy and Canada. Together, Queensland and NSW Health hospitals perform best in operations management followed by performance monitoring. While target management presents scope for improvement, people management is the sphere where these Australian hospitals lag the most. This paper is of interest to both hospital administrators and health care policy-makers aiming to lift management quality at the hospital level as well as at the institutional level, as a vehicle to consistently deliver sustainable high-quality health services. This study provides the first internationally comparable robust measure of management capability in Australian public hospitals, where hospitals are run independently by the state-run healthcare systems. Additionally, this research study contributes to the empirical evidence base on the quality of

  19. Rounding, work intensification and new public management.

    Science.gov (United States)

    Willis, Eileen; Toffoli, Luisa; Henderson, Julie; Couzner, Leah; Hamilton, Patricia; Verrall, Claire; Blackman, Ian

    2016-06-01

    In this study, we argue that contemporary nursing care has been overtaken by new public management strategies aimed at curtailing budgets in the public hospital sector in Australia. Drawing on qualitative interviews with 15 nurses from one public acute hospital with supporting documentary evidence, we demonstrate what happens to nursing work when management imposes rounding as a risk reduction strategy. In the case study outlined rounding was introduced across all wards in response to missed care, which in turn arose as a result of work intensification produced by efficiency, productivity, effectiveness and accountability demands. Rounding is a commercially sponsored practice consistent with new public management. Our study illustrates the impact that new public management strategies such as rounding have on how nurses work, both in terms of work intensity and in who controls their labour.

  20. Shrinking the Administrative State: New Public Management Before and After 9/11

    Directory of Open Access Journals (Sweden)

    Keith M. Henderson

    2005-01-01

    Full Text Available Abstract The New Public Management (NPM is a worldwide administrative phenomenon that is well-exemplified in the United States experience. Nurtured in the Reagan years with "get government off our backs" rhetoric, it matured under President Clinton's National Performance Review and the subsequent Republican approach under President Bush. Both the Democratic and Republican leadership provided a vision of business-like government that is less intrusive yet responsive to citizens. The rate of growth of government programs was to be curtailed. However, the September 11, 2001 terrorist attack on the World Trade Center and the Pentagon gave rise to a "War on Terror" that changed priorities. Traditional public administration values of centralized control, coordination, and inter-governmental cooperation were emphasized. Shrinking of the administrative state was limited to non-Defense, non-Homeland Security arenas.Resumen La Nueva Administración Pública (NPM es un fenómeno mundial que nace de la experiencia norteamericana. Alimentada en los años de la administración Reagan con la retórica de "quitarse al gobierno de las espaldas", éste maduró bajo la crítica nacional a la actuación del Presidente Clinton y el posterior acercamiento republicano bajo el mandato del Presidente Bush. Tanto los líderes demócratas como republicanos proporcionaron una visión de gobierno empresarial, menos intruso pero más responsable a los ciudadanos. El índice de crecimiento de los programas de gobierno iba a ser limitado. Sin embargo, el ataque terrorista del 11 de septiembre del 2001 sobre el World Trade Center y el Pentágono dio pie a la "guerra contra el terrorismo" cambiando las prioridades. Fueron enfatizados los valores tradicionales de la administración pública, el control y la coordinación centralizada y la cooperación intra-gubernamental. La disminución del estado administrativo fue limitado a las áreas que no implican temáticas de defensa y

  1. Career management perspective in public administration

    Directory of Open Access Journals (Sweden)

    Camelia-Olivia ILIES

    2011-12-01

    Full Text Available An innovative public organization must be capable to access, internalize and implement the newest forms of knowledge and capitalize efficiently and effectively the potential of human resources available to it. Economic, political, social, administrative, organizational changes in the context of the global crisis impose permanent efforts aimed to ensure flexibility and to redesign the public organizational architecture, adaptation of career management systems to new conditions. Public organisational entities make substantial efforts to increase the quality of public services, performances and their innovative capacity, using as much as possible the employers’ potential and talent. The paper explores the importance of the concept, role, objectives and management of career from both individual and public organizational perspective. We try to identify the career features and its innovative role in the knowledge-based economy during the crisis, considering the fact that public services have in fact the ultimate responsibility for managing their own careers.

  2. New Public Management - Are we talking same languages?

    DEFF Research Database (Denmark)

    Voxted, Søren; Andersen, Torben; Rasmussen, Erling

    2016-01-01

    Paperet er et longitudinalt studie der beskriver forskelle og ligheder mellem New Zealand og Danmark ved anvendelse og udlægning af NPM teorier......Paperet er et longitudinalt studie der beskriver forskelle og ligheder mellem New Zealand og Danmark ved anvendelse og udlægning af NPM teorier...

  3. Sverige har officielt erklæret NPM-æraen slut

    DEFF Research Database (Denmark)

    Hjortdal, Henrik; Hegnsvad, Mogens

    2016-01-01

    Sverige har nu officielt erkendt at NPM-æraen er slut. Topchefer, forskere og personaleorganisationer bakker op.......Sverige har nu officielt erkendt at NPM-æraen er slut. Topchefer, forskere og personaleorganisationer bakker op....

  4. Mechanisms of Change in Public Management Projects

    Directory of Open Access Journals (Sweden)

    Tiina Soininen

    2013-04-01

    Full Text Available This article draws conclusions from four separate case evaluations from different development programs in Finland and aims to discuss the role of welfare state values in new public management. The study develops a comprehensive picture of the change in public management since 2000. The synthesis of the four case studies follows the critical realism tradition. This article shows that cooperation forms the key mechanism in all public administration projects and in any changes to their structure. The new structure is the postmodern service production sector that still faces many challenges with regard to the traditional welfare state values. One of these is the conflict between the deep-seated moral imperatives of the old welfare state and the goal-attainment priorities of the new public management. While evaluation research has become one of the operations in public administration that fulfills the control function, the value bases of society, management, and evaluations should be balanced together. Also the objectives of public management and evaluations should be more clearly defined in relation to values other than efficiency. An applied science, like evaluation, needs basic social research to formulate, recognize, and conceptualize the new public management structure. Furthermore, there is an urgent requirement to address those values that underpin society as a whole.

  5. PUBLIC-PRIVATE DISTINCTIONS AND STRATEGIC MANAGEMENT

    Directory of Open Access Journals (Sweden)

    Ioan NICOLAE

    2007-01-01

    Full Text Available Public organizations are no longer synonymous with governmental agencies but include many for-profit service organizations as well as the third sector, which is made up of the private NPOs. Such diverse organizations. meet the publicness criterion to the extent that they cannot ignore publicness when dealing with development of strategy. Competitive models of strategic management have little use in organizations with significant degrees of publicness. Instead, a strategy should be sought which enhances cooperation and collaboration. Strategic management in public settings must identify the beliefs and demands of key stakeholders and deal with elaborate fictions held by these individuals to premise development and guide implementation. Strategic managers must carefully collaborate with their oversight body as they fashion a strategy.

  6. Public policy issues in nuclear waste management

    Energy Technology Data Exchange (ETDEWEB)

    Nealey, S.M.; Radford, L.M.

    1978-10-01

    This document aims to raise issues and to analyze them, not resolve them. The issues were: temporal equity, geographic and socioeconomic equity, implementation of a nuclear waste management system, and public involvement.

  7. Public policy issues in nuclear waste management

    Energy Technology Data Exchange (ETDEWEB)

    Nealey, S.M.; Radford, L.M.

    1978-10-01

    This document aims to raise issues and to analyze them, not resolve them. The issues were: temporal equity, geographic and socioeconomic equity, implementation of a nuclear waste management system, and public involvement.

  8. IMPLICATIONS OF CHANGE MANAGEMENT IN PUBLIC ADMINISTRATION

    OpenAIRE

    Laurentiu Barcan Ph. D Student

    2010-01-01

    Governments must face a growing complexity and a greater acute needs more specialized staff to manage and solve new problems. Classical Administration, governed by a set of specific legislation is not adequate for this purpose. But as we shall see, is not redundant, obsolete. The new public management system that focuses on services provided to citizens and requires coherent coexistence and interaction of three areas: public administration, business sector and civil society.

  9. Public involvement in radioactive waste management decisions

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1994-04-01

    Current repository siting efforts focus on Yucca Mountain, Nevada, where DOE`s Office of Civilian Radioactive Waste Management (OCRWM) is conducting exploratory studies to determine if the site is suitable. The state of Nevada has resisted these efforts: it has denied permits, brought suit against DOE, and publicly denounced the federal government`s decision to study Yucca Mountain. The state`s opposition reflects public opinion in Nevada, and has considerably slowed DOE`s progress in studying the site. The Yucca Mountain controversy demonstrates the importance of understanding public attitudes and their potential influence as DOE develops a program to manage radioactive waste. The strength and nature of Nevada`s opposition -- its ability to thwart if not outright derail DOE`s activities -- indicate a need to develop alternative methods for making decisions that affect the public. This report analyzes public participation as a key component of this openness, one that provides a means of garnering acceptance of, or reducing public opposition to, DOE`s radioactive waste management activities, including facility siting and transportation. The first section, Public Perceptions: Attitudes, Trust, and Theory, reviews the risk-perception literature to identify how the public perceives the risks associated with radioactivity. DOE and the Public discusses DOE`s low level of credibility among the general public as the product, in part, of the department`s past actions. This section looks at the three components of the radioactive waste management program -- disposal, storage, and transportation -- and the different ways DOE has approached the problem of public confidence in each case. Midwestern Radioactive Waste Management Histories focuses on selected Midwestern facility-siting and transportation activities involving radioactive materials.

  10. The proteomic signature of NPM/ALK reveals deregulation of multiple cellular pathways.

    Science.gov (United States)

    Lim, Megan S; Carlson, Mary L; Crockett, David K; Fillmore, G Chris; Abbott, David R; Elenitoba-Johnson, Olaotan F; Tripp, Sheryl R; Rassidakis, George Z; Medeiros, L Jeffrey; Szankasi, Philippe; Elenitoba-Johnson, Kojo S J

    2009-08-20

    Constitutive expression of the chimeric NPM/ALK fusion protein encoded by the t(2;5)(p32;q35) is a key oncogenic event in the pathogenesis of most anaplastic large cell lymphomas (ALCLs). The proteomic network alterations produced by this aberration remain largely uncharacterized. Using a mass spectrometry (MS)-driven approach to identify changes in protein expression caused by the NPM/ALK fusion, we identified diverse NPM/ALK-induced changes affecting cell proliferation, ribosome synthesis, survival, apoptosis evasion, angiogenesis, and cytoarchitectural organization. MS-based findings were confirmed using Western blotting and/or immunostaining of NPM/ALK-transfected cells and ALK-deregulated lymphomas. A subset of the proteins distinguished NPM/ALK-positive ALCLs from NPM/ALK-negative ALCLs and Hodgkin lymphoma. The multiple NPM/ALK-deregulated pathways identified by MS analysis also predicted novel biologic effects of NPM/ALK expression. In this regard, we showed loss of cell adhesion as a consequence of NPM/ALK expression in a kinase-dependent manner, and sensitivity of NPM/ALK-positive ALCLs to inhibition of the RAS, p42/44ERK, and FRAP/mTOR signaling pathways. These findings reveal that the NPM/ALK alteration affects diverse cellular pathways, and provide novel insights into NPM/ALK-positive ALCL pathobiology. Our studies carry important implications for the use of MS-driven approaches for the elucidation of neoplastic pathobiology, the identification of novel diagnostic biomarkers, and pathogenetically relevant therapeutic targets.

  11. Public Financial Management in Indonesia: Review of Islamic Public Finance

    OpenAIRE

    Jaelani, Aan

    2017-01-01

    Public financial management by the government is very important in view of the level of welfare in Indonesia is still low, as there are still much poverty with the level of fulfillment of the needs of low, corruption that occurs in every area of government, income distribution is uneven, low economic growth, and various irregularities other budget. With a qualitative approach that emphasises the phenomenon of the social reality and the country's financial management practices in Indonesia, th...

  12. Strategic Management for Public Libraries: A Handbook.

    Science.gov (United States)

    Hayes, Robert M.; Walter, Virginia A.

    Public libraries must operate in a time of increasing change, both within the library community and throughout the larger social and economic environments in which the library must function. This book is a guide to the strategic management of change in community libraries. It addresses the unique circumstances and needs of public libraries and…

  13. The state of Public Performance Management Research

    DEFF Research Database (Denmark)

    Hansen, Morten Balle; Moon, M. Jae

    This paper reviews the PA literature on Public Performance Management (PPM) with the purpose of first providing a broad description of some basic characteristics of this literature and second more specifically to focus on the distinction between conceptualizations and definitions of public perfor...

  14. Public Speaking: Managing Challenging People and Situations.

    Science.gov (United States)

    Baum, Neil; Boughton, Leonarda

    2016-01-01

    Every public speaker has encountered, or most likely will encounter, a difficult member of the audience who disrupts their presentation. This is a source of anxiety and discomfort, not only for the presenter, but for the audience as well. Learning how to manage the disruptive audience member is an art form, just like being a good public speaker. A professional speaker knows how to handle this disruption without making the audience uncomfortable and without embarrassing the disruptor. This article discusses ways to manage the disruptive audience member and will help those of you who do public speaking to tactfully and professionally disengage someone who is ruining your program.

  15. Management accounting versus medical profession discourse

    DEFF Research Database (Denmark)

    Malmmose, Margit

    2015-01-01

    This study uses discourse, ideology and hegemony as a theoretical foundation to investigate the development of the polarised discourses of management accounting and the medical profession during the introduction of a NPM reform in the public health care debate, using Denmark as a case study. 194...... newspaper articles and 73 medical profession articles from 2002 to 2008 are analysed, using critical discourse analysis. The analysis shows that the management accounting discourse becomes the dominating ideology which is embedded in the public rhetorical debate. There are three peculiar outcomes...... perspective of a patient oriented focus to a quantitative focus through strong rationalised arguments. This puts the medical profession in a dilemma concerning their ideological Hippocratic Oath versus the NPM efficiency focus. However, they choose to gradually adopt management accounting terms in their own...

  16. Public sector risk management: a specific model.

    Science.gov (United States)

    Lawlor, Ted

    2002-07-01

    Risk management programs for state mental health authorities are generally limited in scope and reactive in nature. Recent changes in how mental health care is provided render it necessary to redirect the risk management focus from its present institutional basis to a statewide, network-based paradigm that is integrated across public and private inpatient and community programs alike. These changes include treating an increasing number of individuals in less-secure settings and contracting for an increasing number of public mental health services with private providers. The model proposed here is closely linked to the Quality Management Process.

  17. Effect of Managers on Public Service Performance

    DEFF Research Database (Denmark)

    Mikkelsen, Maria Falk

    This report provides an overview of the PhD dissertation “Effects of Managers on Public Service Performance” carried out at the Department of Political Science, Aarhus University and SFI – The Danish National Centre for Social Research. The dissertation is part of the research project “School...... Management, Teaching, and Student Performance” supported by the Danish Strategic Research Council (now Innovation Fund Denmark) and headed by professor Søren Winter. The dissertation explores the effects of managers on public service performance. By combining theoretical insights and research designs from......? The Interplay between Decentralized Authority and Managerial Factors.” Invited for revise and resubmit [referred to as “Decentralized authority”]. C. Mikkelsen, Maria Falk 2015, “Trade-offs or Superman(agers)? The Effect of Public Managers on Production and Process Performance.” Under review [referred...

  18. Public And Private Leadership And Performance Management

    Directory of Open Access Journals (Sweden)

    Christine (Mihaescu Demeter

    2013-05-01

    Full Text Available The aim of this article is to make a comparing between the private and public leadership. We analyze (1 whether there are differences between public and private sector leadership based on some variables related to job complexity of a manager (including the managerial behaviour, job autonomy, and job clarity, decision-making vs policymaking process and the stakeholders vs political influence, and (2 to assess the degree of their effects on the managerial competences and performance management. Our study is conducted from the Romanian perspective on public organizations. As the methodology used, in order to identify the perception on political influence in Romanian public administration we conducted a survey among civil servants at central and local level. Our research is based on the empirical analysis of the relevant literature in public administration, leadership and organizational performance.

  19. Understanding and managing organizational change: implications for public health management.

    Science.gov (United States)

    Thompson, Jon M

    2010-01-01

    Managing organizational change has become a significant responsibility of managers. Managing the change process within public health organizations is important because appropriately and systematically managing change is linked to improved organizational performance. However, change is difficult and the change process poses formidable challenges for managers. Managers themselves face increased pressure to respond to environmental influences and provide the necessary leadership to their organizations in the change process. In fact, managing organizational change has become a key competency for healthcare managers. This article addresses the important topic of organizational change in public health organizations. It provides a conceptual foundation for understanding organizational change and its relationship to healthcare organizational performance, and then discusses the types and nature of change, using some examples and evidence from those organizations that have successfully managed change. A framework for guiding public health managers in the change management process is provided. The article concludes with suggested management competencies to establish a change-oriented organization with the culture and capacity for change.

  20. QUALITY OF MANAGEMENT IN PUBLIC ADMINISTRATION

    Directory of Open Access Journals (Sweden)

    Ileana (BĂDULESCUANASTASE

    2015-04-01

    Full Text Available This paper shows the emmergence of strong aspects that require a deep transformation of the organization through the implementation of the Quality and management. We start from knowing the status of the organization, the environment, and through continuous improvement, the implementation of the Quality of management will try to reach stages closer to excellence. In this sense, the applyable practice in Public Administration must start from something elementary and simple, to allow the realization of some improvements, with a modern administration, with a number of considerable tasks. The introduction of a system of Quality management must be the decision of superior management, and the idea that sustains the arguments must be the following: the growth of productivity, the raise of income, the improvement of the image, the growth of competitiveness, the reducing of costs, the improvement of the environment. This way, reductions of consumptions in the Public Administration through improvements in the Quality of management must be determined.

  1. Publication ethics and the ghost management of medical publication.

    Science.gov (United States)

    Sismondo, Sergio; Doucet, Mathieu

    2010-07-01

    It is by now no secret that some scientific articles are ghost authored - that is, written by someone other than the person whose name appears at the top of the article. Ghost authorship, however, is only one sort of ghosting. In this article, we present evidence that pharmaceutical companies engage in the ghost management of the scientific literature, by controlling or shaping several crucial steps in the research, writing, and publication of scientific articles. Ghost management allows the pharmaceutical industry to shape the literature in ways that serve its interests. This article aims to reinforce and expand publication ethics as an important area of concern for bioethics. Since ghost-managed research is primarily undertaken in the interests of marketing, large quantities of medical research violate not just publication norms but also research ethics. Much of this research involves human subjects, and yet is performed not primarily to increase knowledge for broad human benefit, but to disseminate results in the service of profits. Those who sponsor, manage, conduct, and publish such research therefore behave unethically, since they put patients at risk without justification. This leads us to a strong conclusion: if medical journals want to ensure that the research they publish is ethically sound, they should not publish articles that are commercially sponsored.

  2. Public Relations Ethics in Information Management

    Directory of Open Access Journals (Sweden)

    Hrvoje Jakopović

    2013-06-01

    Full Text Available Public relations is involved in all communication between an organization and the public. In the contemporary world, PR practitioners have become the facilitators of information. Information and communication technology (ICT have imposed new rules in the field of public relations. Communication strategy and information management have become crucial parts of modern public relations. People change their habits with regard to the consumption of traditional and new media. The challenges imposed by the development of information and communication technology are also related to understanding the new information society. For that reason information ethics deals with the ethical implications of dissemination, use, development and safety of information. Public relations follow new information and communication trends, and they need to build firm ethical principles for the age of information. The author examines the ethical implications of the framing concept in public relations.

  3. Structural polymorphism in the N-terminal oligomerization domain of NPM1.

    Science.gov (United States)

    Mitrea, Diana M; Grace, Christy R; Buljan, Marija; Yun, Mi-Kyung; Pytel, Nicholas J; Satumba, John; Nourse, Amanda; Park, Cheon-Gil; Madan Babu, M; White, Stephen W; Kriwacki, Richard W

    2014-03-25

    Nucleophosmin (NPM1) is a multifunctional phospho-protein with critical roles in ribosome biogenesis, tumor suppression, and nucleolar stress response. Here we show that the N-terminal oligomerization domain of NPM1 (Npm-N) exhibits structural polymorphism by populating conformational states ranging from a highly ordered, folded pentamer to a highly disordered monomer. The monomer-pentamer equilibrium is modulated by posttranslational modification and protein binding. Phosphorylation drives the equilibrium in favor of monomeric forms, and this effect can be reversed by Npm-N binding to its interaction partners. We have identified a short, arginine-rich linear motif in NPM1 binding partners that mediates Npm-N oligomerization. We propose that the diverse functional repertoire associated with NPM1 is controlled through a regulated unfolding mechanism signaled through posttranslational modifications and intermolecular interactions.

  4. Interaction with RXR is necessary for NPM-RAR-induced myeloid differentiation blockade.

    Science.gov (United States)

    Rush, Elizabeth A; Pollock, Sheri L; Abecassis, Irina; Redner, Robert L

    2013-12-01

    The t(5;17)(q35;q21) APL variant results in expression of a fusion protein linking the N-terminus of nucleophosmin (NPM) to the C-terminus of the retinoic acid receptor alpha (RAR). We have previously shown that NPM-RAR is capable of binding to DNA either as a homodimer or heterodimer with RXR. To determine the biological significance of NPM-RAR/RXR interaction, we developed two mutants of NPM-RAR that showed markedly diminished ability to bind RXR. U937 subclones expressing the NPM-RAR mutants showed significantly less inhibition of vitamin D3/TGFbeta-induced differentiation, compared with NPM-RAR. These results support the hypothesis that RXR interaction is necessary for NPM-RAR-mediated myeloid maturation arrest.

  5. Crizotinib-resistant NPM-ALK mutants confer differential sensitivity to unrelated Alk inhibitors.

    Science.gov (United States)

    Ceccon, Monica; Mologni, Luca; Bisson, William; Scapozza, Leonardo; Gambacorti-Passerini, Carlo

    2013-02-01

    The dual ALK/MET inhibitor crizotinib was recently approved for the treatment of metastatic and late-stage ALK+ NSCLC, and is currently in clinical trial for other ALK-related diseases. As predicted after other tyrosine kinase inhibitors' clinical experience, the first mutations that confer resistance to crizotinib have been described in patients with non-small cell lung cancer (NSCLC) and in one patient inflammatory myofibroblastic tumor (IMT). Here, we focused our attention on the anaplastic large cell lymphoma (ALCL), where the oncogenic fusion protein NPM-ALK, responsible for 70% to 80% of cases, represents an ideal crizotinib target. We selected and characterized 2 human NPM-ALK+ ALCL cell lines, KARPAS-299 and SUP-M2, able to survive and proliferate at different crizotinib concentrations. Sequencing of ALK kinase domain revealed that a single mutation became predominant at high crizotinib doses in each cell line, namely L1196Q and I1171N in Karpas-299 and SUP-M2 cells, respectively. These mutations also conferred resistance to crizotinib in Ba/F3 cells expressing human NPM-ALK. The resistant cell populations, as well as mutated Ba/F3 cells, were characterized for sensitivity to two additional ALK inhibitors: the dual ALK/EGFR inhibitor AP26113 and NVP-TAE684. While L1196Q-positive cell lines were sensitive to both inhibitors, cells carrying I1171N substitution showed cross-resistance to all ALK inhibitors tested. This study provides potentially relevant information for the management of patients with ALCL that may relapse after crizotinib treatment.

  6. Customer orientation among employees in public administration: a transnational, longitudinal study.

    Science.gov (United States)

    Korunka, Christian; Scharitzer, Dieter; Carayon, Pascale; Hoonakker, Peter; Sonnek, Angelika; Sainfort, Francois

    2007-05-01

    The relation between ergonomic principles and quality management initiatives, both, in the private and public sector, has received increasing attention in the recent years. Customer orientation among employees is not only an important quality principle, but also an essential prerequisite for customer satisfaction, especially in service organizations. In this context, the objective of introducing new public management (NPM) in public-service organizations is to increase customer orientation among employees who are at the forefront of service providing. In this study, we developed a short scale to measure perceived customer orientation. In two separate longitudinal studies carried out in Austria and the US, we analyzed changes in customer orientation resulting from the introduction of NPM. In both organizations, we observed a significant increase in customer orientation. Perceived customer orientation was related to job characteristics, organizational characteristics and employee quality of working life. Creating positive influences on these characteristics within the framework of an organizational change process has positive effects on employee customer orientation.

  7. First line management in the public sector

    DEFF Research Database (Denmark)

    Voxted, Søren

    The paper will examines and discusses the results from a structured observational study, wherein 50 first-line managers from the public sector in Denmark in five areas of employment where observed. These observational studies are a key contribution in the ‘greenhouse for management’ project......, the study explores which tasks the managers primarily perform, divided into eight categories of activities. Third, it is examined how the manager’s usage of time is divided among the individual tasks. The results of the above data can be used both to provide a comprehensive characterization of municipal...... first-line managers’ work and to illuminate differences between first-line managers from different occupational groups. The second question relates to current debate about the degree of professionalized management among the municipal first-line managers. In both the international and Danish management...

  8. Change management in the public sector.

    Science.gov (United States)

    Caple, L

    1995-01-01

    Summarizes the management of change in a high profile public service with more than its fair share of political influences. Demonstrates the scale of change possible, given a clear strategy and a strong managerial commitment. Argues that this leads to high productivity, quality and value for money, with a strong element of organizational loyalty and ownership of the end product.

  9. Real time model for public transportation management

    Directory of Open Access Journals (Sweden)

    Ireneusz Celiński

    2014-03-01

    Full Text Available Background: The article outlines managing a public transportation fleet in the dynamic aspect. There are currently many technical possibilities of identifying demand in the transportation network. It is also possible to indicate legitimate basis of estimating and steering demand. The article describes a general public transportation fleet management concept based on balancing demand and supply. Material and methods: The presented method utilizes a matrix description of demand for transportation based on telemetric and telecommunication data. Emphasis was placed mainly on a general concept and not the manner in which data was collected by other researchers.  Results: The above model gave results in the form of a system for managing a fleet in real-time. The objective of the system is also to optimally utilize means of transportation at the disposal of service providers. Conclusions: The presented concept enables a new perspective on managing public transportation fleets. In case of implementation, the project would facilitate, among others, designing dynamic timetables, updated based on observed demand, and even designing dynamic points of access to public transportation lines. Further research should encompass so-called rerouting based on dynamic measurements of the characteristics of the transportation system.

  10. Management Control Packages in Public Sector Organizations

    NARCIS (Netherlands)

    van der Kolk, Berend

    2016-01-01

    This thesis examines configurations of management control (MC) packages in public sector organizations, and how they relate to employee motivation and behavior. Using multiple case studies and a survey study, this thesis contributes to the extant literature in three ways. First, it enhances the unde

  11. Public Order Management in a Virtual World

    NARCIS (Netherlands)

    Buiel, E.F.T.; Hulst, A.H. van der; Voogd, J.; Oprins, E.A.P.B.

    2013-01-01

    In urban operations, military commanders have to take into account the civilians present in the operation area. This is why Public Order Management (POM) is an important subject of their training. The organization of POM field training is challenging. It requires lots of humans to act as crowds. It

  12. Public Order Management in a Virtual World

    NARCIS (Netherlands)

    Buiel, E.F.T.; Hulst, A.H. van der; Voogd, J.; Oprins, E.A.P.B.

    2013-01-01

    In urban operations, military commanders have to take into account the civilians present in the operation area. This is why Public Order Management (POM) is an important subject of their training. The organization of POM field training is challenging. It requires lots of humans to act as crowds. It

  13. MANAGING OPERATIONS IMPROVEMENT IN ROMANIAN PUBLIC SERVICES

    Directory of Open Access Journals (Sweden)

    BALOI IONUT-COSMIN

    2015-07-01

    Full Text Available This paper aims to develop a pleading for the transfer of best practices to improving the operational activity in the Romanian public institutions. The practice of implementation demonstrates that the perception of many executives in the Romanian private enterprises regarding the set of tools to improve processes and assimilation of lean philosophy is not a very favorable and encouraging one. It can be said that only some large enterprises had successfully introduced in their daily practice and organization the improvement principles, the operational optimization and the elimination of waste sources. In the SMEs, and especially in the services the experiences are isolated, but they have demonstrated the usefulness (the frequency of saving goals indicate, indeed, the need for proliferation of continuous improvement principles. Regarding the public organizations, the implementation of the new management system of designing and operating the current practices is pretty unknown, accepted at declarative level, but becomes, when is planned and implemented rather a burden on managers who should take on this challenge. Both in public management and private management, today the focus is on people and relationships (processes and projects, starting of course with the work organization. The good practices successfully proved in the private management in the recent decades are transferred today to public institutions; and the Romanian public organizations tend to adapt, also in terms of processes optimization. The study aims to analyze the functioning of the hypothetical management system of processes improvements, respectively the applying of lean tools and principles within the public Romanian institution. They are treated some dysfunctions observed within the process of understanding the utility aspects and throughout the assuming of operational improvement goals within these organizations. The qualitative observations, the critical interpretations and

  14. NPM phosphorylation stimulates Cdk1, overrides G2/M checkpoint and increases leukemic blasts in mice.

    Science.gov (United States)

    Du, Wei; Zhou, Yun; Pike, Suzette; Pang, Qishen

    2010-02-01

    An elevated level of nucleophosmin (NPM) is often found in actively proliferative cells including human tumors. To identify the regulatory role for NPM phosphorylation in proliferation and cell cycle control, a series of mutants targeting the consensus cyclin-dependent kinase (CDK) phosphorylation sites was created to mimic or abrogate either single-site or multi-site phosphorylation. Simultaneous inactivation of two CDK phosphorylation sites at Ser10 and Ser70 (NPM-AA) induced G(2)/M cell cycle arrest, phosphorylation of Cdk1 at Tyr15 (Cdc2(Tyr15)) and increased cytoplasmic accumulation of Cdc25C. Strikingly, stress-induced Cdk1(Tyr15) and Cdc25C sequestration was suppressed by expression of a phosphomimetic NPM mutant created on the same CDK sites (S10E/S70E, NPM-EE). Further analysis revealed that phosphorylation of NPM at both Ser10 and Ser70 was required for proper interaction between Cdk1 and Cdc25C. Moreover, NPM-EE directly bound to Cdc25C and prevented phosphorylation of Cdc25C at Ser216 during mitosis. Finally, NPM-EE overrided stress-induced G(2)/M arrest and increased leukemia blasts in a NOD/SCID xenograft model. Thus, these findings reveal a novel function of NPM on regulation of cell cycle progression, in which phosphorylation of NPM controls cell cycle progression at G(2)/M transition through modulation of Cdk1 and Cdc25C activities.

  15. SHP1 tyrosine phosphatase negatively regulates NPM-ALK tyrosine kinase signaling.

    Science.gov (United States)

    Honorat, Jean-François; Ragab, Ashraf; Lamant, Laurence; Delsol, Georges; Ragab-Thomas, Jeannie

    2006-05-15

    Anaplastic large-cell lymphoma (ALCL) is frequently associated with the 2;5 translocation and expresses the NPM-ALK fusion protein, which possesses a constitutive tyrosine kinase activity. We analyzed SHP1 tyrosine phosphatase expression and activity in 3 ALK-positive ALCL cell lines (Karpas 299, Cost, and SU-DHL1) and in lymph node biopsies (n = 40). We found an inverse correlation between the level of NPM-ALK phosphorylation and SHP1 phosphatase activity. Pull-down and coimmunoprecipitation experiments demonstrated a SHP1/NPM-ALK association. Furthermore, confocal microscopy performed on ALCL cell lines and biopsy specimens showed the colocalization of the 2 proteins in cytoplasmic bodies containing Y664-phosphorylated NPM-ALK. Dephosphorylation of NPM-ALK by SHP1 demonstrated that NPM-ALK was a SHP1 substrate. Downregulation of SHP1 expression by RNAi in Karpas cells led to hyperphosphorylation of NPM-ALK, STAT3 activation, and increase in cell proliferation. Furthermore, SHP1 overexpression in 3T3 fibroblasts stably expressing NPM-ALK led to the decrease of NPM-ALK phosphorylation, lower cell proliferation, and tumor progression in nude mice. These findings show that SHP1 is a negative regulator of NPM-ALK signaling. The use of tissue microarrays revealed that 50% of ALK-positive ALCLs were positive for SHP1. Our results suggest that SHP1 could be a critical enzyme in ALCL biology and a potential therapeutic target.

  16. Phosphorylated STAT3 physically interacts with NPM and transcriptionally enhances its expression in cancer.

    Science.gov (United States)

    Ren, Z; Aerts, J L; Pen, J J; Heirman, C; Breckpot, K; De Grève, J

    2015-03-26

    The signal transducer and activator of transcription 3 (STAT3) can be activated by the tyrosine kinase domain of the chimeric protein nucleophosmin/anaplastic lymphoma kinase (NPM/ALK), and has a pivotal role in mediating NPM/ALK-related malignant cell transformation. Although the role of STAT3 and wild-type NPM in oncogenesis has been extensively investigated, the relationship between both molecules in cancer remains poorly understood. In the present study, we first demonstrate that STAT3 phosphorylation at tyrosine 705 is accompanied by a concomitant increase in the expression level of NPM. Nuclear co-translocation of phosphorylated STAT3 with NPM can be triggered by interferon-alpha (IFN-α) stimulation of Jurkat cells and phosphorylated STAT3 co-localizes with NPM in cancer cells showing constitutive STAT3 activation. We further demonstrate that STAT3 phosphorylation can transcriptionally mediate NPM upregulation in IFN-α-stimulated Jurkat cells and is responsible for maintaining its expression in cancer cells showing constitutive STAT3 activation. Inhibition of STAT3 phosphorylation or knockdown of NPM expression abrogates their simultaneous transnuclear movements. Finally, we found evidence for a physical interaction between NPM and STAT3 in conditions of STAT3 activation. In conclusion, NPM is a downstream effector of the STAT3 signaling, and can facilitate the nuclear entry of phosphorylated STAT3. These observations might open novel opportunities for targeting the STAT3 pathway in cancer.

  17. 77 FR 27440 - New England Fishery Management Council; Public Meeting

    Science.gov (United States)

    2012-05-10

    ... National Oceanic and Atmospheric Administration New England Fishery Management Council; Public Meeting...), Commerce. ACTION: Notice; public meeting. SUMMARY: The New England Fishery Management Council (Council) is... INFORMATION CONTACT: Paul J. Howard, Executive Director, New England Fishery Management Council;...

  18. The service of public services performance management

    DEFF Research Database (Denmark)

    Lystbæk, Christian Tang

    . Performance measures are rational tools, part of the rational panoply of effective management and organizational functioning. Their recommendation lies in their rationality. The literature suggests three main theoretical perspectives on the purpose of performance measurement of public services. One...... as compensating for the absence of effective competition in supply markets. Thus, according to this view, because dissatisfied service users are unable to go elsewhere and taxpayers cannot act like shareholders to keep in efficient providers in check, the role of performance measurement is to manage supply...... the existence of significant concern about the actual impact, the costs and unintended consequences associated with performance measurement.  Performance measurement and management have been part of the political agenda within the public sphere since their adoption in the post-Second World War period...

  19. Public access management as an adaptive wildlife management tool

    Science.gov (United States)

    Ouren, Douglas S.; Watts, Raymond D.

    2005-01-01

    Wildlife populations across the United States are benefiting from improved wildlife management techniques. However, these benefits also create new challenges including overpopulation, disease, increased winter kill, and forage degradation. These issues have become the challenges for natural resource managers and landowners. Specifically, elk (Cervus elaphus) populations in the Gunnison River Valley of Colorado are growing and causing increased resource damage on public and private lands. On public lands elk threaten sage grouse habitat and compete with domestic livestock for available forage; on private lands they diminish available livestock forage. Management of elk and elk habitat in this area is a shared responsibility of the NPS (Black Canyon of the Gunnison National Park and Curecanti National Recreation Area), BLM (Uncompahgre Field Office), USFS (Gunnison National Forest), and the CDOW (Colorado Division of Wildlife). All of these agencies participate in this research and adaptive management project.

  20. Performance Management Compared across Public Services

    DEFF Research Database (Denmark)

    Bjørnholt, Bente; Agger Nielsen, Jeppe; Lindholst, Christian

    on extent literature we expect performance management systems to be operationalized more tightly, freed from definitional conflicts and with more rigorous and quantitative measures in areas with low governance complexity (technical services) while performance management systems will appear with opposite...... service areas and draw lessons from these differences. On this backdrop this paper investigates theoretical assumptions on performance management systems through a cross-comparison of two public service areas (technical and social services) which differ in theoretically important dimensions. Drawing...... characteristics in areas with high governance complexity (social service). We find that the performance management systems unexpectedly converged in characteristics across the two service areas, and even appeared with more rigid monitoring and control functions in social services compared to newer developments...

  1. Literature promotion in Public Libraries

    DEFF Research Database (Denmark)

    Kann-Christensen, Nanna; Balling, Gitte

    2011-01-01

    This article discusses a model that can be used in order to analyse notions on literature promotion in public libraries. The model integrates different issues which interact with how literature promotion is understood and thought of in public libraries. Besides cultural policy we regard the logics...... of new public management (NPM) and professional logics in the field of public libraries. Cultural policy along with the identification of underlying logics present among politicians, government officials, managers and librarians/promoters of literature, play an important part in creating an understanding...... of literature promotion in Danish libraries. Thus the basic premise for the development of the model is that cultural policy (Policy) has an important influence on notions on literature promotion and other activities in public libraries, but that cultural policy must be seen in some kind of interaction...

  2. Literature promotion in Public Libraries

    DEFF Research Database (Denmark)

    Kann-Christensen, Nanna; Balling, Gitte

    2011-01-01

    This article discusses a model that can be used in order to analyse notions on literature promotion in public libraries. The model integrates different issues which interact with how literature promotion is understood and thought of in public libraries. Besides cultural policy we regard the logics...... of new public management (NPM) and professional logics in the field of public libraries. Cultural policy along with the identification of underlying logics present among politicians, government officials, managers and librarians/promoters of literature, play an important part in creating an understanding...... of literature promotion in Danish libraries. Thus the basic premise for the development of the model is that cultural policy (Policy) has an important influence on notions on literature promotion and other activities in public libraries, but that cultural policy must be seen in some kind of interaction...

  3. BUDGETARY CLASSIFICATIONS’ ROLE IN PUBLIC FINANCIAL MANAGEMENT

    Directory of Open Access Journals (Sweden)

    Gyorgy Adina Cristina

    2010-07-01

    Full Text Available Budgetary classifications are a vital condition for a sound budgetary management. To be a good and useful classification, some rules should be respected. The international experience could offer us guiding lines which contribute to this purpose. In our paper we tried to present some basic elements of a budgetary classification, stressing on their utility in practice: financial management, reporting, on various criteria, and electronic processing. In last part is presented a functional example of such a classification which proved its utility in Romanian public financial sector.

  4. Implementing public employment policy

    DEFF Research Database (Denmark)

    Larsen, Flemming; Bredgaard, Thomas

    disciplining of the unemployed (work first) (cf.Bredgaard & Larsen, 2005; Sol & Westerweld, 2005). It is, however, remarkable that in the research field there seems to be a division of labour so that changes in public administration and changes in the substance of employment policies are dealt with separately....... But there is an interesting question to investigate here: whether and if so how, NPM-inspired reforms are related to changes in employment policy towards a work-first approach? Are changes in public management systems created as deliberate policy changes, or do they bring about more indirect and unintended policy changes...... an intended policy shift, there seems to be very little public discussion about them. Far-reaching policy changes become politically invisible and de-politicized. Our empirical case is the contracting out of the public employment services in Australia, the Netherlands and Denmark. The main question is what...

  5. Excess of NPM-ALK oncogenic signaling promotes cellular apoptosis and drug dependency.

    Science.gov (United States)

    Ceccon, M; Merlo, M E Boggio; Mologni, L; Poggio, T; Varesio, L M; Menotti, M; Bombelli, S; Rigolio, R; Manazza, A D; Di Giacomo, F; Ambrogio, C; Giudici, G; Casati, C; Mastini, C; Compagno, M; Turner, S D; Gambacorti-Passerini, C; Chiarle, R; Voena, C

    2016-07-21

    Most of the anaplastic large-cell lymphoma (ALCL) cases carry the t(2;5; p23;q35) that produces the fusion protein NPM-ALK (nucleophosmin-anaplastic lymphoma kinase). NPM-ALK-deregulated kinase activity drives several pathways that support malignant transformation of lymphoma cells. We found that in ALK-rearranged ALCL cell lines, NPM-ALK was distributed in equal amounts between the cytoplasm and the nucleus. Only the cytoplasmic portion was catalytically active in both cell lines and primary ALCL, whereas the nuclear portion was inactive because of heterodimerization with NPM1. Thus, about 50% of the NPM-ALK is not active and sequestered as NPM-ALK/NPM1 heterodimers in the nucleus. Overexpression or relocalization of NPM-ALK to the cytoplasm by NPM genetic knockout or knockdown caused ERK1/2 (extracellular signal-regulated protein kinases 1 and 2) increased phosphorylation and cell death through the engagement of an ATM/Chk2- and γH2AX (phosphorylated H2A histone family member X)-mediated DNA-damage response. Remarkably, human NPM-ALK-amplified cell lines resistant to ALK tyrosine kinase inhibitors (TKIs) underwent apoptosis upon drug withdrawal as a consequence of ERK1/2 hyperactivation. Altogether, these findings indicate that an excess of NPM-ALK activation and signaling induces apoptosis via oncogenic stress responses. A 'drug holiday' where the ALK TKI treatment is suspended could represent a therapeutic option in cells that become resistant by NPM-ALK amplification.

  6. Animal Waste Management Practices and Perceptions on Public ...

    African Journals Online (AJOL)

    Animal Waste Management Practices and Perceptions on Public and Environmental Health Risks. ... Huria: Journal of the Open University of Tanzania ... and public health risks associated with improper management of animal wastes in 66 ...

  7. Consequences of failure to manage public sector financial records ...

    African Journals Online (AJOL)

    ... and Southern Africa Regional Branch of the International Council on Archives ... The focus of this article is the management of public sector financial records. ... the records generated by the public financial management system provide the ...

  8. NPM1 deletion is associated with gross chromosomal rearrangements in leukemia.

    Directory of Open Access Journals (Sweden)

    Roberta La Starza

    Full Text Available BACKGROUND: NPM1 gene at chromosome 5q35 is involved in recurrent translocations in leukemia and lymphoma. It also undergoes mutations in 60% of adult acute myeloid leukemia (AML cases with normal karyotype. The incidence and significance of NPM1 deletion in human leukemia have not been elucidated. METHODOLOGY AND PRINCIPAL FINDINGS: Bone marrow samples from 145 patients with myelodysplastic syndromes (MDS and AML were included in this study. Cytogenetically 43 cases had isolated 5q-, 84 cases had 5q- plus other changes and 18 cases had complex karyotype without 5q deletion. FISH and direct sequencing investigated the NPM1 gene. NPM1 deletion was an uncommon event in the "5q- syndrome" but occurred in over 40% of cases with high risk MDS/AML with complex karyotypes and 5q loss. It originated from large 5q chromosome deletions. Simultaneous exon 12 mutations were never found. NPM1 gene status was related to the pattern of complex cytogenetic aberrations. NPM1 haploinsufficiency was significantly associated with monosomies (p<0.001 and gross chromosomal rearrangements, i.e., markers, rings, and double minutes (p<0.001, while NPM1 disomy was associated with structural changes (p=0.013. Interestingly, in complex karyotypes with 5q- TP53 deletion and/or mutations are not specifically associated with NPM1 deletion. CONCLUSIONS AND SIGNIFICANCE: NPM1/5q35 deletion is a consistent event in MDS/AML with a 5q-/-5 in complex karyotypes. NPM1 deletion and NPM1 exon 12 mutations appear to be mutually exclusive and are associated with two distinct cytogenetic subsets of MDS and AML.

  9. Maternally inherited npm2 mRNA is crucial for egg developmental competence in zebrafish.

    Science.gov (United States)

    Bouleau, Aurélien; Desvignes, Thomas; Traverso, Juan Martin; Nguyen, Thaovi; Chesnel, Franck; Fauvel, Christian; Bobe, Julien

    2014-08-01

    The molecular mechanisms underlying and determining egg developmental competence remain poorly understood in vertebrates. Nucleoplasmin (Npm2) is one of the few known maternal effect genes in mammals, but this maternal effect has never been demonstrated in nonmammalian species. A link between developmental competence and the abundance of npm2 maternal mRNA in the egg was previously established using a teleost fish model for egg quality. The importance of maternal npm2 mRNA for egg developmental competence remains unknown in any vertebrate species. In the present study, we aimed to characterize the contribution of npm2 maternal mRNA to early developmental success in zebrafish using a knockdown strategy. We report here the oocyte-specific expression of npm2 and maternal inheritance of npm2 mRNA in zebrafish eggs. The knockdown of the protein translated from this maternal mRNA results in developmental arrest before the onset of epiboly and subsequent embryonic death, a phenotype also observed in embryos lacking zygotic transcription. Npm2 knockdown also results in impaired transcription of the first-wave zygotic genes. Our results show that npm2 is also a maternal effect gene in a nonmammalian vertebrate species and that maternally inherited npm2 mRNA is crucial for egg developmental competence. We also show that de novo protein synthesis from npm2 maternal mRNA is critical for developmental success beyond the blastula stage and required for zygotic genome activation. Finally, our results suggest that npm2 maternal mRNA is an important molecular factor of egg quality in fish and possibly in all vertebrates.

  10. Public Use Management Plan James River National Wildlife Refuge 1992

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The Public Use Plan for James River National Wildlife Refuge is intended to identify public use issues, objectives, and appropriate strategies for managing public...

  11. 77 FR 27440 - New England Fishery Management Council; Public Hearings

    Science.gov (United States)

    2012-05-10

    ... National Oceanic and Atmospheric Administration New England Fishery Management Council; Public Hearings...), Commerce. ACTION: Public Hearing; Request for Comments. SUMMARY: The New England Fishery Management Council... Northeast Small-Mesh Multispecies Fishery Management Plan (FMP). DATES: The public hearing will be held...

  12. Effect of Managers on Public Service Performance

    DEFF Research Database (Denmark)

    Mikkelsen, Maria Falk

    and society as a whole (Esping-Andersen 2002; Grossman 2006; Heckman, Lochner, and Todd 2006). Teaching quality and school performance have attracted much academic as well as political attention and debate in recent decades. Particularly in Denmark, which for a number of years has been among the OECD...... countries spending most on education (OECD 2014a), while still performing at the OECD average in PISA tests and on equity measures (OECD 2014b). Studying ways of improving school performance is therefore important in its own right. Another advantage of using Danish schools as the setting......? Analyzing the Impact of Managers on Organizational Performance in Public and Private Organizations” Working paper [referred to as “Public vs. private”]....

  13. Public sector managers and work stress

    DEFF Research Database (Denmark)

    Møller, Ann-Kristina Løkke; Madsen, Henning

    2014-01-01

    -related stress may cause absence from work it may influence production and the health system. If preventive measures can be taken a positive impact on the economy may be the result. Originality/value: Work-related stress has been studied before. But little focus has been given to the public sector and expecially...... and the way it is practiced (n=1,500, response rate 72 per cent) are applied. For the purpose of this paper only specific information related to the perception of work stress among public sector managers is analyzed (n=400). Findings: The perception of stress are influenced by factors like gender, managerial...... level, work load, the influence on own job situation, if they have children living at home as well as the percentage of work-at-home. Research limitations/implications: In general survey work stress is one among a larger number of issues. This fact may influence the validity of the information...

  14. Proteasome activity influences UV-mediated subnuclear localization changes of NPM.

    Science.gov (United States)

    Moore, Henna M; Bai, Baoyan; Matilainen, Olli; Colis, Laureen; Peltonen, Karita; Laiho, Marikki

    2013-01-01

    UV damage activates cellular stress signaling pathways, causes DNA helix distortions and inhibits transcription by RNA polymerases I and II. In particular, the nucleolus, which is the site of RNA polymerase I transcription and ribosome biogenesis, disintegrates following UV damage. The disintegration is characterized by reorganization of the subnucleolar structures and change of localization of many nucleolar proteins. Here we have queried the basis of localization change of nucleophosmin (NPM), a nucleolar granular component protein, which is increasingly detected in the nucleoplasm following UV radiation. Using photobleaching experiments of NPM-fluorescent fusion protein in live human cells we show that NPM mobility increases after UV damage. However, we show that the increase in NPM nucleoplasmic abundance after UV is independent of UV-activated cellular stress and DNA damage signaling pathways. Unexpectedly, we find that proteasome activity affects NPM redistribution. NPM nucleolar expression was maintained when the UV-treated cells were exposed to proteasome inhibitors or when the expression of proteasome subunits was inhibited using RNAi. However, there was no evidence of increased NPM turnover in the UV damaged cells, or that ubiquitin or ubiquitin recycling affected NPM localization. These findings suggest that proteasome activity couples to nucleolar protein localizations in UV damage stress.

  15. Delocalization and destabilization of the Arf tumor suppressor by the leukemia-associated NPM mutant.

    Science.gov (United States)

    Colombo, Emanuela; Martinelli, Paola; Zamponi, Raffaella; Shing, Danielle C; Bonetti, Paola; Luzi, Lucilla; Volorio, Sara; Bernard, Loris; Pruneri, Giancarlo; Alcalay, Myriam; Pelicci, Pier Giuseppe

    2006-03-15

    One third of acute myeloid leukemias (AMLs) are characterized by the aberrant cytoplasmic localization of nucleophosmin (NPM) due to mutations within its putative nucleolar localization signal. NPM mutations are mutually exclusive with major AML-associated chromosome rearrangements and are frequently associated with a normal karyotype, suggesting that they are critical during leukemogenesis. The underlying molecular mechanisms are, however, unknown. NPM is a nucleocytoplasmic shuttling protein that has been implicated in several cellular processes, including ribosome biogenesis, centrosome duplication, cell cycle progression, and stress response. It has been recently shown that NPM is required for the stabilization and proper nucleolar localization of the tumor suppressor p19(Arf). We report here that the AML-associated NPM mutant localizes mainly in the cytoplasm due to an alteration of its nucleus-cytoplasmic shuttling equilibrium, forms a direct complex with p19(Arf), but is unable to protect it from degradation. Consequently, cells or leukemic blasts expressing the NPM mutant have low levels of cytoplasmic Arf. Furthermore, we show that expression of the NPM mutant reduces the ability of Arf to initiate a p53 response and to induce cell cycle arrest. Inactivation of p19(Arf), a key regulator of the p53-dependent cellular response to oncogene expression, might therefore contribute to leukemogenesis in AMLs with mutated NPM.

  16. Study of nucleophosmin (NPM) gene mutation in patients with acute myeloid leukemia and myelodysplastic syndromes

    Institute of Scientific and Technical Information of China (English)

    张悦

    2006-01-01

    Objective To investigate nucleophosmin (NPM) gene mutations in patients with de novo acute myeloid leukemia (AML) with normal cytogenetics and primary myelodysplastic syndromes (MDS). Methods Genomic DNA corresponding to exon 12 of NPM gene was amplified by polymerase chain reaction (PCR) in 40 AML patients (28 case untreated and 12 in first remission) and

  17. Crystal Structure and Function of Human Nucleoplasmin (Npm2): A Histone Chaperone in Oocytes and Embryos

    Energy Technology Data Exchange (ETDEWEB)

    O Platonova; I Akey; J Head; C Akey

    2011-12-31

    Human Npm2 is an ortholog of Xenopus nucleoplasmin (Np), a chaperone that binds histones. We have determined the crystal structure of a truncated Npm2-core at 1.9 {angstrom} resolution and show that the N-terminal domains of Npm2 and Np form similar pentamers. This allowed us to model an Npm2 decamer which may be formed by hydrogen bonds between quasi-conserved residues in the interface between two pentamers. Interestingly, the Npm2 pentamer lacks a prototypical A1-acidic tract in each of its subunits. This feature may be responsible for the inability of Npm2-core to bind histones. However, Npm2 with a large acidic tract in its C-terminal tail (Npm2-A2) is able to bind histones and form large complexes. Fluorescence resonance energy transfer experiments and biochemical analysis of loop mutations support the premise that nucleoplasmins form decamers when they bind H2A-H2B dimers and H3-H4 tetramers simultaneously. In the absence of histone tetramers, these chaperones bind H2A-H2B dimers with a single pentamer forming the central hub. When taken together, our data provide insights into the mechanism of histone binding by nucleoplasmins.

  18. 78 FR 928 - New England Fishery Management Council; Public Meeting

    Science.gov (United States)

    2013-01-07

    ... Administration (NOAA), Commerce. ACTION: Notice; public meeting. SUMMARY: The New England Fishery Management... National Oceanic and Atmospheric Administration RIN 0648-XC428 New England Fishery Management Council... CONTACT: Paul J. Howard, Executive Director, New England Fishery Management Council; telephone: (978)...

  19. 76 FR 70420 - New England Fishery Management Council; Public Meeting

    Science.gov (United States)

    2011-11-14

    ... Administration (NOAA), Commerce. ACTION: Notice; public meeting. SUMMARY: The New England Fishery Management... National Oceanic and Atmospheric Administration RIN 0648-XA815 New England Fishery Management Council... CONTACT: Paul J. Howard, Executive Director, New England Fishery Management Council; telephone: (978)...

  20. 75 FR 63146 - New England Fishery Management Council; Public Meeting

    Science.gov (United States)

    2010-10-14

    ... Administration (NOAA), Commerce. ACTION: Notice of a public meeting. SUMMARY: The New England Fishery Management... National Oceanic and Atmospheric Administration RIN 0648-XZ64 New England Fishery Management Council.... Howard, Executive Director, New England Fishery Management Council; telephone: (978)...

  1. 76 FR 41216 - New England Fishery Management Council; Public Meeting

    Science.gov (United States)

    2011-07-13

    ... Administration (NOAA), Commerce. ACTION: Notice; public meeting. SUMMARY: The New England Fishery Management... National Oceanic and Atmospheric Administration RIN 0648-XA561 New England Fishery Management Council... New England Fishery Management Council, 50 Water Street, Mill 2, Newburyport, MA 01950;...

  2. 75 FR 49466 - New England Fishery Management Council; Public Meeting

    Science.gov (United States)

    2010-08-13

    ... Administration (NOAA), Commerce. ACTION: Notice; public meeting. SUMMARY: The New England Fishery Management... National Oceanic and Atmospheric Administration RIN 0648-XY17 New England Fishery Management Council... INFORMATION CONTACT: Paul J. Howard, Executive Director, New England Fishery Management Council;...

  3. 76 FR 43266 - New England Fishery Management Council; Public Meeting

    Science.gov (United States)

    2011-07-20

    ... Fisheries Service (NMFS). ACTION: Notice; Public meeting. SUMMARY: The New England Fishery Management... National Oceanic and Atmospheric Administration RIN 0648-XA582 New England Fishery Management Council.... Howard, Executive Director, New England Fishery Management Council; telephone: (978)...

  4. 78 FR 53729 - New England Fishery Management Council; Public Meeting

    Science.gov (United States)

    2013-08-30

    ... Administration (NOAA), Commerce. ACTION: Notice; public meeting. SUMMARY: The New England Fishery Management... National Oceanic and Atmospheric Administration RIN 0648-XC840 New England Fishery Management Council... INFORMATION CONTACT: Thomas A. Nies, Executive Director, New England Fishery Management Council;...

  5. 78 FR 62587 - New England Fishery Management Council; Public Meeting

    Science.gov (United States)

    2013-10-22

    ... Administration (NOAA), Commerce. ACTION: Notice; public meeting. SUMMARY: The New England Fishery Management... National Oceanic and Atmospheric Administration RIN 0648-XC923 New England Fishery Management Council...: Thomas A. Nies, Executive Director, New England Fishery Management Council; telephone: (978)...

  6. 78 FR 48860 - New England Fishery Management Council; Public Meetings

    Science.gov (United States)

    2013-08-12

    ... Administration (NOAA), Commerce. ACTION: Notice; public meetings. SUMMARY: The New England Fishery Management... National Oceanic and Atmospheric Administration RIN 0648-XC802 New England Fishery Management Council...: Thomas A. Nies, Executive Director, ] New England Fishery Management Council; telephone: (978)...

  7. 76 FR 64073 - New England Fishery Management Council; Public Meetings

    Science.gov (United States)

    2011-10-17

    ... Administration (NOAA), Commerce. ACTION: Notice; public meetings. SUMMARY: The New England Fishery Management... National Oceanic and Atmospheric Administration RIN 0648-XA763 New England Fishery Management Council... locations, see SUPPLEMENTARY INFORMATION. Council address: New England Fishery Management Council, 50...

  8. Public Management Reform without Managers: The Case of German Public Schools

    Science.gov (United States)

    Mintrop, Rick

    2015-01-01

    Purpose: The purpose of this paper is to discuss the role of principals in light of public management reforms taking place in the German educational system and in reference to the empirical patterns uncovered by the papers contained in the Special Issue. Policy makers have created new expectations and new technologies that seem to suggest to…

  9. FLT3 and NPM1 mutations in Chinese patients with acute myeloid leukemia and normal cytogenetics.

    Science.gov (United States)

    Wang, Lei; Xu, Wei-lai; Meng, Hai-tao; Qian, Wen-bin; Mai, Wen-yuan; Tong, Hong-yan; Mao, Li-ping; Tong, Yin; Qian, Jie-jing; Lou, Yin-jun; Chen, Zhi-mei; Wang, Yun-gui; Jin, Jie

    2010-10-01

    Mutations of fms-like tyrosine kinase 3 (FLT3) and nucleophosmin (NPM1) exon 12 genes are the most common abnormalities in adult acute myeloid leukemia (AML) with normal cytogenetics. To assess the prognostic impact of the two gene mutations in Chinese AML patients, we used multiplex polymerase chain reaction (PCR) and capillary electrophoresis to screen 76 AML patients with normal cytogenetics for mutations in FLT3 internal tandem duplication (FLT3/ITD) and exon 12 of the NPM1 gene. FLT3/ITD mutation was detected in 15 (19.7%) of 76 subjects, and NPM1 mutation in 20 (26.3%) subjects. Seven (9.2%) cases were positive for both FLT3/ITD and NPM1 mutations. Significantly more FLT3/ITD aberration was detected in subjects with French-American-British (FAB) M1 (42.8%). NPM1 mutation was frequently detected in subjects with M5 (47.1%) and infrequently in subjects with M2 (11.1%). FLT3 and NPM1 mutations were significantly associated with a higher white blood cell count in peripheral blood and a lower CD34 antigen expression, but not age, sex, or platelet count. Statistical analysis revealed that the FLT3/ITD-positive group had a lower complete remission (CR) rate (53.3% vs. 83.6%). Survival analysis showed that the FLT3/ITD-positive/NPM1 mutation-negative group had worse overall survival (OS) and relapse-free survival (RFS). The FLT3/ITD-positive/NPM1 mutation-positive group showed a trend towards favorable survival compared with the FLT3/ITD-positive/NPM1 mutation-negative group (P=0.069). Our results indicate that the FLT3/ITD mutation might be a prognostic factor for an unfavorable outcome in Chinese AML subjects with normal cytogenetics, while NPM1 mutation may be a favorable prognostic factor for OS and RFS in the presence of FLT3/ITD.

  10. Annotated Bibliography of Selected NPRDC Publications on Total Quality Management

    Science.gov (United States)

    1990-12-01

    AD-A233 573 Annotated Bibliography of Select NPRDC Publications on Total Quality Management Approved for public release; distribution is unlimited...Deming’s prin- ness is called Total Quality Management , The Role of NPRDC ciples into organizational practice and, or TQM. subsequently, to evaluate...Annotated Bibliography of Selected NPRDC Publications on Total Quality Management Deming’s Management Principles1 1. Create and publish to all employees

  11. Impact of Performance Management in Public and Private Organizations

    DEFF Research Database (Denmark)

    Hvidman, Ulrik; Andersen, Simon Calmar

    2014-01-01

    Recent theoretical developments suggest that management actions have different impacts on outcomes in public and private organizations. This proposition is important to public organizations’ widespread import of private sector management tools such as performance management. This article examines...... how performance management influences performance outcomes in otherwise similar public and private organizations. Showing that the factors expected to diminish the impact of performance management parallel the organizational characteristics of public organizations, we hypothesize that this type...... of management is less effective in public organizations. A difference-in-differences model based on survey data on management in Danish public and private schools, combined with administrative data of students’ test scores, confirms the hypothesis. The results have important implications for the transfer...

  12. Managerial Talent, Motivation, and Self-Selection into Public Management

    NARCIS (Netherlands)

    J. Delfgaauw (Josse); A.J. Dur (Robert)

    2008-01-01

    textabstractThe quality of public management is a recurrent concern in many countries. Calls to attract the economy's best and brightest managers to the public sector abound. This paper studies self-selection into managerial and non-managerial positions in the public and private sector, using a mode

  13. US Department of Energy environmental management advisory board public meeting

    Energy Technology Data Exchange (ETDEWEB)

    1994-03-01

    Contents of this publication include: list of participants; March 14, 1994--opening of public meeting and subcommittee reports, and public comment session; March 15, 1994--presentation by Thomas P. Grumbly, assistant secretary for environmental management, presentations by senior environmental management officials, and committee business.

  14. 76 FR 20959 - Pacific Fishery Management Council; Public Meeting

    Science.gov (United States)

    2011-04-14

    ... Pacific mackerel stock assessment for 2011, in order to inform fisheries management decisions for the 2011... National Oceanic and Atmospheric Administration RIN 0648-XA366 Pacific Fishery Management Council; Public... (NOAA), Commerce. ACTION: Notice of a public meeting. SUMMARY: The Pacific Fishery Management...

  15. 77 FR 8809 - New England Fishery Management Council; Public Hearings

    Science.gov (United States)

    2012-02-15

    ... Administration (NOAA), Commerce. ACTION: Notice; public hearings. SUMMARY: The New England Fishery Management... National Oceanic and Atmospheric Administration RIN 0648-XB006 New England Fishery Management Council... Herring Fishery Management Plan (FMP). DATES: Written public comments must be received on or before 5...

  16. 76 FR 32143 - New England Fishery Management Council; Public Meeting

    Science.gov (United States)

    2011-06-03

    ... National Oceanic and Atmospheric Administration New England Fishery Management Council; Public Meeting...), Commerce. ACTION: Public meeting. SUMMARY: The New England Fishery Management Council (Council) will hold a... the New England Fishery Management Council, 50 Water Street, Mill 2, Newburyport, MA 01950;...

  17. Down-regulated expression of NPM1 in IMS-M2 cell line by (-)-epigallocatechin-3-gallate

    Institute of Scientific and Technical Information of China (English)

    Hoang Thanh Chi; Bui Thi Kim Ly; Hoang Anh Vu; Yuko Sato; Phu Chi Dung; Phan Thi Xinh

    2014-01-01

    Objective: To investigate the inhibited effect of epigallocatechin-3-gallate (EGCG) on the expression of NPM1 in IMS-M2 cells harboring the NPM1 mutations.Methods:Cell proliferation assay was performed to test the effects of EGCG on cell growth of IMS-M2 cells harboring the NPM1 mutations. Western blot analysis were performed to test the protein expression of NPM1, AKT, those associated with apoptosis. Results: EGCG can down-regulate the expression of NPM1 in IMS-M2 cells harboring the NPM1 mutations. Moreover, EGCG also suppressed the cell proliferation and induced apoptosis in IMS-M2 cells.Conclusions:The results suggested that EGCG could be considered as a reagent for treatment of AML patients with NPM1 mutations.

  18. Phosphorylation of multifunctional nucleolar protein nucleophosmin (NPM1) by aurora kinase B is critical for mitotic progression.

    Science.gov (United States)

    Shandilya, Jayasha; Senapati, Parijat; Dhanasekaran, Karthigeyan; Bangalore, Suma S; Kumar, Manoj; Kishore, A Hari; Bhat, Akshay; Kodaganur, Gopinath S; Kundu, Tapas K

    2014-06-27

    The functional association of NPM1 with Aurora kinases is well documented. Surprisingly, although NPM1 is a well characterized phosphoprotein, it is unknown whether it is a substrate of Aurora kinases. We have found that Aurora kinases A and B can phosphorylate NPM1 at a single serine residue, Ser125, in vitro and in vivo. Phosphorylated-S125-NPM1 (pS125-NPM1) localizes to the midbody region during late cytokinesis where it colocalizes with Aurora B. The overexpression of mutant (S125A) NPM1 resulted in the deregulation of centrosome duplication and mitotic defects possibly due to cytokinesis failure. These data suggest that Aurora kinase B-mediated phosphorylation of NPM1 plays a critical role during mitosis, which could have wider implications in oncogenesis.

  19. Targeting Chromatin Regulators Inhibits Leukemogenic Gene Expression in NPM1 Mutant Leukemia.

    Science.gov (United States)

    Kühn, Michael W M; Song, Evelyn; Feng, Zhaohui; Sinha, Amit; Chen, Chun-Wei; Deshpande, Aniruddha J; Cusan, Monica; Farnoud, Noushin; Mupo, Annalisa; Grove, Carolyn; Koche, Richard; Bradner, James E; de Stanchina, Elisa; Vassiliou, George S; Hoshii, Takayuki; Armstrong, Scott A

    2016-10-01

    Homeobox (HOX) proteins and the receptor tyrosine kinase FLT3 are frequently highly expressed and mutated in acute myeloid leukemia (AML). Aberrant HOX expression is found in nearly all AMLs that harbor a mutation in the Nucleophosmin (NPM1) gene, and FLT3 is concomitantly mutated in approximately 60% of these cases. Little is known about how mutant NPM1 (NPM1(mut)) cells maintain aberrant gene expression. Here, we demonstrate that the histone modifiers MLL1 and DOT1L control HOX and FLT3 expression and differentiation in NPM1(mut) AML. Using a CRISPR/Cas9 genome editing domain screen, we show NPM1(mut) AML to be exceptionally dependent on the menin binding site in MLL1. Pharmacologic small-molecule inhibition of the menin-MLL1 protein interaction had profound antileukemic activity in human and murine models of NPM1(mut) AML. Combined pharmacologic inhibition of menin-MLL1 and DOT1L resulted in dramatic suppression of HOX and FLT3 expression, induction of differentiation, and superior activity against NPM1(mut) leukemia.

  20. The frequency of NPM1 mutations in childhood acute myeloid leukemia

    Directory of Open Access Journals (Sweden)

    Karamolegou Kalliopi

    2010-10-01

    Full Text Available Abstract Background Mutations in the nucleophosmin (NPM1 gene have been solely associated with childhood acute myeloid leukemia (AML. We evaluated the frequency of NPM1 mutations in childhood AML, their relation to clinical and cytogenetic features and the presence of common FLT3 and RAS mutations. Results NPM1 mutations were found in 8% of cases. They involved the typical type 'A' mutation and one novel mutation characterized by two individual base pair substitutions, which resulted in 2 amino acid changes (W290 and (S293 in the NPM protein. FLT3/ITD mutations were observed in 12% of the cases and in one NPM1-mutated case bearing also t(8;21 (q22;q22. No common RAS mutations were identified. Conclusions A relatively consistent NPM1 mutation rate was observed, but with variations in types of mutations. The role of different types of NPM1 mutations, either individually or in the presence of other common gene mutations may be essential for childhood AML prognosis.

  1. Mouse models of NPM1-mutated acute myeloid leukemia: biological and clinical implications.

    Science.gov (United States)

    Sportoletti, P; Varasano, E; Rossi, R; Mupo, A; Tiacci, E; Vassiliou, G; Martelli, M P; Falini, B

    2015-02-01

    Acute myeloid leukemia (AML) carrying nucleophosmin (NPM1) mutations displays distinct biological and clinical features that led to its inclusion as a provisional disease entity in the 2008 World Health Organization (WHO) classification of myeloid neoplasms. Studies of the molecular mechanisms underlying the pathogenesis of NPM1-mutated AML have benefited greatly from several mouse models of this leukemia developed over the past few years. Immunocompromised mice xenografted with NPM1-mutated AML served as the first valuable tool for defining the biology of the disease in vivo. Subsequently, genetically engineered mouse models of the NPM1 mutation, including transgenic and knock-in alleles, allowed the generation of mice with a constant genotype and a reproducible phenotype. These models have been critical for investigating the nature of the molecular effects of these mutations, defining the function of leukemic stem cells in NPM1-mutated AML, identifying chemoresistant preleukemic hemopoietic stem cells and unraveling the key molecular events that cooperate with NPM1 mutations to induce AML in vivo. Moreover, they can serve as a platform for the discovery and validation of new antileukemic drugs in vivo. Advances derived from the analysis of these mouse models promise to greatly accelerate the development of new molecularly targeted therapies for patients with NPM1-mutated AML.

  2. IMPROVING PUBLIC SERVICES THROUGH A ORGANIZATIONAL PERFORMANCE MANAGEMENT

    Directory of Open Access Journals (Sweden)

    IOANA STĂNCESCU

    2010-01-01

    Full Text Available Organizational management, systemic approach, is known more as a system Management, that set of factors such as organizational, methodological information, decisions and relationships between them, as outlined, that will achieve objectives. Fundamental objective of management in public organizations involved in the holders of public office positions and leadership and execution in this area an additional responsibility to manage all types of resources available to the public sector, namely human resources, information, material and financial.Summary of process management is focusing on human coordination of joint work. An important role in this process is modernizing organizational management and quality delivery of public services or the institution's activities, public services more efficient by implementing innovative tools, leading to a government driven process to a results-oriented public service.

  3. Managing the Cooperative Network: The Public Administration Model.

    Science.gov (United States)

    Diener, Ronald E.

    1981-01-01

    Recommends that library administrators turn to public administration models in preference to business administration models for network management; this choice is predicated on the not-for-profit aspects of public service organizations. (RAA)

  4. Analysis of nucleophosmin-anaplastic lymphoma kinase (NPM-ALK)-reactive CD8(+) T cell responses in children with NPM-ALK(+) anaplastic large cell lymphoma.

    Science.gov (United States)

    K Singh, V; Werner, S; Hackstein, H; Lennerz, V; Reiter, A; Wölfel, T; Damm-Welk, C; Woessmann, W

    2016-10-01

    Cellular immune responses against the oncoantigen anaplastic lymphoma kinase (ALK) in patients with ALK-positive anaplastic large cell lymphoma (ALCL) have been detected using peptide-based approaches in individuals preselected for human leucocyte antigen (HLA)-A*02:01. In this study, we aimed to evaluate nucleophosmin (NPM)-ALK-specific CD8(+) T cell responses in ALCL patients ensuring endogenous peptide processing of ALK antigens and avoiding HLA preselection. We also examined the HLA class I restriction of ALK-specific CD8(+) T cells. Autologous dendritic cells (DCs) transfected with in-vitro-transcribed RNA (IVT-RNA) encoding NPM-ALK were used as antigen-presenting cells for T cell stimulation. Responder T lymphocytes were tested in interferon-gamma enzyme-linked immunospot (ELISPOT) assays with NPM-ALK-transfected autologous DCs as well as CV-1 in Origin with SV40 genes (COS-7) cells co-transfected with genes encoding the patients' HLA class I alleles and with NPM-ALK encoding cDNA to verify responses and define the HLA restrictions of specific T cell responses. NPM-ALK-specific CD8(+) T cell responses were detected in three of five ALK-positive ALCL patients tested between 1 and 13 years after diagnosis. The three patients had also maintained anti-ALK antibody responses. No reactivity was detected in samples from five healthy donors. The NPM-ALK-specific CD8(+) T cell responses were restricted by HLA-C-alleles (C*06:02 and C*12:02) in all three cases. This approach allowed for the detection of NPM-ALK-reactive T cells, irrespective of the individual HLA status, up to 9 years after ALCL diagnosis.

  5. Reversal of microRNA-150 silencing disadvantages crizotinib-resistant NPM-ALK(+) cell growth.

    Science.gov (United States)

    Hoareau-Aveilla, Coralie; Valentin, Thibaud; Daugrois, Camille; Quelen, Cathy; Mitou, Géraldine; Quentin, Samuel; Jia, Jinsong; Spicuglia, Salvatore; Ferrier, Pierre; Ceccon, Monica; Giuriato, Sylvie; Gambacorti-Passerini, Carlo; Brousset, Pierre; Lamant, Laurence; Meggetto, Fabienne

    2015-09-01

    The regulatory microRNA miR-150 is involved in the development of hemopathies and is downregulated in T-lymphomas, such as anaplastic large-cell lymphoma (ALCL) tumors. ALCL is defined by the presence or absence of translocations that activate the anaplastic lymphoma kinase (ALK), with nucleophosmin-ALK (NPM-ALK) fusions being the most common. Here, we compared samples of primary NPM-ALK(+) and NPM-ALK(-) ALCL to investigate the role of miR-150 downstream of NPM-ALK. Methylation of the MIR150 gene was substantially elevated in NPM-ALK(+) biopsies and correlated with reduced miR-150 expression. In NPM-ALK(+) cell lines, DNA hypermethylation-mediated miR-150 repression required ALK-dependent pathways, as ALK inhibition restored miR-150 expression. Moreover, epigenetic silencing of miR-150 was due to the activation of STAT3, a major downstream substrate of NPM-ALK, in cooperation with DNA methyltransferase 1 (DNMT1). Accordingly, miR-150 repression was turned off following treatment with the DNMT inhibitor, decitabine. In murine NPM-ALK(+) xenograft models, miR-150 upregulation induced antineoplastic activity. Treatment of crizotinib-resistant NPM-ALK(+) KARPAS-299-CR06 cells with decitabine or ectopic miR-150 expression reduced viability and growth. Altogether, our results suggest that hypomethylating drugs, alone or in combination with other agents, may benefit ALK(+) patients harboring tumors resistant to crizotinib and other anti-ALK tyrosine kinase inhibitors (TKIs). Moreover, these results support further work on miR-150 in these and other ALK(+) malignancies.

  6. Reversal of microRNA-150 silencing disadvantages crizotinib-resistant NPM-ALK(+) cell growth

    Science.gov (United States)

    Hoareau-Aveilla, Coralie; Valentin, Thibaud; Daugrois, Camille; Quelen, Cathy; Mitou, Géraldine; Quentin, Samuel; Jia, Jinsong; Spicuglia, Salvatore; Ferrier, Pierre; Ceccon, Monica; Giuriato, Sylvie; Gambacorti-Passerini, Carlo; Brousset, Pierre; Lamant, Laurence; Meggetto, Fabienne

    2015-01-01

    The regulatory microRNA miR-150 is involved in the development of hemopathies and is downregulated in T-lymphomas, such as anaplastic large-cell lymphoma (ALCL) tumors. ALCL is defined by the presence or absence of translocations that activate the anaplastic lymphoma kinase (ALK), with nucleophosmin-ALK (NPM-ALK) fusions being the most common. Here, we compared samples of primary NPM-ALK(+) and NPM-ALK(–) ALCL to investigate the role of miR-150 downstream of NPM-ALK. Methylation of the MIR150 gene was substantially elevated in NPM-ALK(+) biopsies and correlated with reduced miR-150 expression. In NPM-ALK(+) cell lines, DNA hypermethylation–mediated miR-150 repression required ALK-dependent pathways, as ALK inhibition restored miR-150 expression. Moreover, epigenetic silencing of miR-150 was due to the activation of STAT3, a major downstream substrate of NPM-ALK, in cooperation with DNA methyltransferase 1 (DNMT1). Accordingly, miR-150 repression was turned off following treatment with the DNMT inhibitor, decitabine. In murine NPM-ALK(+) xenograft models, miR-150 upregulation induced antineoplastic activity. Treatment of crizotinib-resistant NPM-ALK(+) KARPAS-299-CR06 cells with decitabine or ectopic miR-150 expression reduced viability and growth. Altogether, our results suggest that hypomethylating drugs, alone or in combination with other agents, may benefit ALK(+) patients harboring tumors resistant to crizotinib and other anti-ALK tyrosine kinase inhibitors (TKIs). Moreover, these results support further work on miR-150 in these and other ALK(+) malignancies. PMID:26258416

  7. Prognostic Impact of Nucleophosmin 1 (NPM1 Gene Mutations in Egyptian Acute Myeloid Leukemia Patients

    Directory of Open Access Journals (Sweden)

    Magda Zidan

    2013-06-01

    Full Text Available OBJECTIVE: Somatic mutations of the nucleophosmin gene (NPM1, which alter the subcellular localization of the product, are the most frequent mutations in patients with acute myeloid leukemia. The aim of the study was to assess the prevalence and prognostic impact of NPM1 gene mutations in adult AML patients. METHODS: Polymerase chain reaction and single-strand conformation polymorphism (PCR-SSCP were used to screen 55 AML patients for mutations of NPM1 gene. RESULTS: NPM1 mutations were found in 12 (21.8% of 55 patients, significantly associated with higher total leukocytie count, marrow blast percentage (p=0.03 and p=0.02, respectively, and M5 subtype (p<0.001. Patients with NPM1 mutations had significantly higher complete remission rates (p=0.003 and a trend to lower rates of mortality, relapse and refractory disease (p=0.28, p=0.45 and p=0.08, respectively. Survival analysis showed significantly longer disease-free survival (mean 18.635±1.229 versus 11.041±1.250 months, p=0.044 and overall survival (mean 19.810±1.624 versus 12.063±1.244 months, p=0.041 in patients with NPM1 mutations compared with those without. Multivariate analyses confirmed NPM1 mutation as a significant independent predictor for disease-free survival (HR=0.066, p=0.001 and overall survival (HR=0.125, p=0.002. CONCLUSION: NPM1 mutation is a prognostic factor for a favorable outcome in Egyptian population. This finding is of major clinical importance since it strongly suggests that NPM1 mutations may allow one to divide the heterogeneous patient group of AML into prognostically different subgroups.

  8. Public Governance Principles in General Education School Management of Latvia

    OpenAIRE

    Rečs, Normunds

    2015-01-01

    In contemporary world the effect of globalisation and information technologies cause transformational processes of states` public management that promote the application of new managament approaches and principles in public institution management.The changes in the public managament have effected and still effects processes of management also in education. The increase of school autonomy, a stronger focus on the process of education and its results created the need to expand the application o...

  9. NPM1 mutations in therapy-related acute myeloid leukemia with uncharacteristic features

    DEFF Research Database (Denmark)

    Andersen, Morten Tolstrup; Andersen, Mette Klarskov; Christiansen, D.H.

    2008-01-01

    Frameshift mutations of the nucleophosmin gene (NPM1) were recently reported as a frequently occurring abnormality in patients with de novo acute myeloid leukemia (AML). To evaluate the frequency of NPM1 mutations in patients with therapy-related myelodysplasia (t-MDS) and therapy-related AML (t......-/-7, the most frequent abnormalities of t-MDS/t-AML, were not observed (P=0.002). This raises the question whether some of the cases presenting NPM1 mutations were in fact cases of de novo leukemia. The close association to class I mutations and the inverse association to class II mutations suggest...

  10. A Public Service-Dominant Logic for the Executive Education of Public Managers

    Science.gov (United States)

    Hiedemann, Alexander M.; Nasi, Greta; Saporito, Raffaella

    2017-01-01

    Building on the concept of Public Service-Dominant Logic (PSDL), this article aims to apply the public service-dominant logic to executive education. We argue that fit-for-purpose and effective executive master programs for public managers (EMPA) need to be designed from a public service perspective. Framing executive education as a service…

  11. 78 FR 31519 - New England Fishery Management Council; Public Meeting

    Science.gov (United States)

    2013-05-24

    ... England Fishery Management Council; Public Meeting AGENCY: National Marine Fisheries Service (NMFS...: The New England Fishery Management Council's (Council) Groundfish Oversight Committee will meet to... held at the Providence Biltmore Hotel, 11 Dorrance Street, Providence, RI 02903; telephone: (401) 421...

  12. EVALUATION OF THE PROJECT MANAGEMENT ORGANISATIONAL ABILITY OF PUBLIC ORGANISATIONS

    Directory of Open Access Journals (Sweden)

    Florescu Margareta

    2012-12-01

    Full Text Available The quality of the results of a project or a public programme, as well as the quality of project management consist in management process performance.This analysis tool promotes the idea of initiating a new organisational/functional policy – organisational tools regarding project management, a new standard concerning the complexity of the project and the associated risk, as well as a new standard concerning the project management organisational/functional ability. Political decision makers, public organisation managers, but project managers as well are the main people in charge of elaborating and taking responsibility for these standards and policies within the organisations they manage and represent.

  13. Managing Public's Complacency and Public Preparedness in Response to 2006 Avian Influenza Crisis in Turkey

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    Naim Kapucu

    2016-02-01

    Full Text Available Public complacency is one of the problems complicating emergency preparedness and response operations for disaster managers. Effective disaster management is possible to the extent that affected communities cooperate with disaster management. Focusing on the 2006 avian influenza crisis in Turkey, this article analyzes whether the strategies and tools used by government agencies responsible for disaster management were effective in reducing public complacency, and, thus, increasing overall perceived public preparedness and response. Specifically, communication tools used for information collection, organization and dissemination were analyzed to see whether they led increased public situational awareness and immediate public reaction to the crisis. Findings suggest that government's internal preparation and use of communication tools had an impact on the level of the information the public exposed to, while reduced complacency or public reaction to the crisis had an impact on the overall perceived public preparedness.

  14. Public debt managers' behaviour: Interactions with macro policies

    NARCIS (Netherlands)

    Hoogduin, L.; Öztürk, B.; Wierts, P.

    2011-01-01

    We investigate the evolution of public debt management, the policy behaviour of debt managers, and the interaction of debt management with financial stability and monetary policy. The main focus is on the euro area. Empirical estimations of a debt management reaction function indicate that the share

  15. Estrogen stimulates the proliferation of human endometrial cancer cells by stabilizing nucleophosmin/B23 (NPM/B23).

    Science.gov (United States)

    Chao, Angel; Lin, Chiao-Yun; Tsai, Chia-Lung; Hsueh, Swei; Lin, Ying-Yu; Lin, Cheng-Tao; Chou, Hung-Hsueh; Wang, Tzu-Hao; Lai, Chyong-Huey; Wang, Hsin-Shih

    2013-02-01

    Unopposed estrogen exposure is an important factor in the tumorigenesis of endometrial cancer. Nucleophosmin/B23 (NPM/B23), a phosphoprotein that has pleiotropic functions in cells, plays an important role in various cancers. However, the regulatory role of NPM/B23 in estrogen signaling in endometrial cancer has not been explored. Here, we report that NPM/B23 was required for estrogen-induced endometrial proliferation, and the increase in NPM/B23 was estrogen receptor α-dependent. Furthermore, estrogen increased NPM/B23 protein levels by repressing its ubiquitination and subsequently stabilizing the protein. The overexpression of the alternate reading frame (ARF) suppressed the estrogen-induced increase in the NPM/B23 protein levels, indicating that ARF inhibited the observed estrogen-mediated NPM/B23 stabilization. Our results suggest that one of the effects of estrogen on endometrial proliferation is the suppression of the NPM/B23-ARF interaction and the subsequent increase in NPM/B23 protein levels. This novel characterization of NPM/B23 in estrogen-mediated cell proliferation may extend our understanding of the tumorigenesis of steroid hormone-related cancers.

  16. Inhibition of Rac controls NPM-ALK-dependent lymphoma development and dissemination.

    Science.gov (United States)

    Colomba, A; Giuriato, S; Dejean, E; Thornber, K; Delsol, G; Tronchère, H; Meggetto, F; Payrastre, B; Gaits-Iacovoni, F

    2011-06-01

    Nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) is a tyrosine kinase oncogene responsible for the pathogenesis of the majority of human ALK-positive lymphomas. We recently reported that it activated the Rac1 GTPase in anaplastic large-cell lymphoma (ALCL), leading to Rac-dependent formation of active invadopodia required for invasiveness. Herein, we went further into the study of this pathway and used the inhibitor of Rac, NSC23766, to validate its potential as a molecular target in ALCL in vitro and in vivo in a xenograft model and in a conditional model of NPM-ALK transgenic mice. Our data demonstrate that Rac regulates important effectors of NPM-ALK-induced transformation such as Erk1/2, p38 and Akt. Moreover, inhibition of Rac signaling abrogates NPM-ALK-elicited disease progression and metastasis in mice, highlighting the potential of small GTPases and their regulators as additional therapic targets in lymphomas.

  17. FLT3 and NPM-1 mutations in a cohort of acute promyelocytic leukemia patients from India

    Directory of Open Access Journals (Sweden)

    Suchitra Swaminathan

    2014-01-01

    Results: Frequency of FLT3/internal tandem duplication and FLT3/tyrosine kinase domain was found to be 25% and 7% respectively. We observed a high frequency of NPM1 mutation (45% in the present population of APL patients.

  18. The role and impact of the New Public Management in the Turkish National Police and its personnel management systemYeni Kamu Yönetiminin Emniyet Teşkilatındaki yeri ve emniyet personel yönetimine etkileri

    Directory of Open Access Journals (Sweden)

    Mutlu Köseli

    2014-04-01

    Full Text Available It is clear that the New Public Management (NPM approaches which are mostly themes of private sector, would impact/contribute to the Turkish National Police (TNP that has a workforce over 200 thousand. This study attempts to identify how far the NPM applications are implemented and how is it perceieved by the managing level officials in the TNP. To the aforementioned ends, this study conducted several interviews with open ended questions and found at the first place that mid and upper level managers of the TNP believe that the NPM has resulted in managers questioning of shared values, functions, services and the role of the TNP and in turn strive for making progress on the role of the organization. This study also found that the NPM approaches has made notible changes in the TNP and its services/fuctions such as de-bureaucratization to certain levels, increased citizen satisfaction. It however identified that these NPM changes are not based on systematic and structural institutional developments but based only on individual efforts which are not sustainable. Moreover, it found that the notions of NPM can not easily be applied and practiced in the TNP due to rigid systemic structures that resist any change. As a result, despite the fact the NPM has cause certain progresses with individual efforts, it is quite clear that there must be structural and systematic changes for NPM applications to be practiced sustainably in the TNP. ÖzetÖzel sektör yönetim anlayışının kamu yönetiminde de uygulanmaya başlanmasıyla ortaya çıkan Yeni Kamu Yönetimi (YKY yaklaşımının 200.000’in üzerinde mensubu olan polis teşkilatının da yönetimine oldukça katkı sağlayacağı şüphe götürmezdir. YKY yaklaşımının polis teşkilatında ne kadar uygulama alanı bulduğunun araştırılması gereken bir husus olduğundan hareketle bu çalışma yapılmış ve YKY’nin Türk Polis Teşkilatı yöneticileri tarafından nasıl alg

  19. Strategic management of Public Hospitals' medical services.

    Science.gov (United States)

    Hao, Aimin; Yi, Tao; Li, Xia; Wei, Lei; Huang, Pei; Xu, Xinzhou; Yi, Lihua

    2016-01-01

    Purpose: The quality of medical services provided by competing public hospitals is the primary consideration of the public in determining the selection of a specific hospital for treatment. The main objective of strategic planning is to improve the quality of public hospital medical services. This paper provides an introduction to the history, significance, principles and practices of public hospital medical service strategy, as well as advancing the opinion that public hospital service strategy must not merely aim to produce but actually result in the highest possible level of quality, convenience, efficiency and patient satisfaction.

  20. Elements of a Knowledge Management Guide for Public Sector Organizations

    Science.gov (United States)

    Harris, Mark Cameron

    2013-01-01

    This study explored the factors that are critical to the success of public (government) sector knowledge management initiatives and the lessons from private sector knowledge management and organizational learning that apply in the public sector. The goal was to create a concise guide, based on research-validated success factors, to aid government…

  1. 78 FR 59657 - Pacific Fishery Management Council; Public Meeting

    Science.gov (United States)

    2013-09-27

    ... National Oceanic and Atmospheric Administration RIN 0648-XC890 Pacific Fishery Management Council; Public... (NOAA), Commerce. ACTION: Notice of public meeting. SUMMARY: The Pacific Fishery Management Council... Watertown Hotel Seattle, 4242 Roosevelt Way NE., Seattle, WA 98105; telephone: (206) 826-4242. Council...

  2. 77 FR 70419 - Caribbean Fishery Management Council; Public Meetings

    Science.gov (United States)

    2012-11-26

    ... National Oceanic and Atmospheric Administration RIN 0648-XC363 Caribbean Fishery Management Council; Public... (NOAA), Commerce. ACTION: Notice of public meetings. SUMMARY: The Caribbean Fishery Management Council... Morning Star Hotel, 4 Estate Bakkeroe, St. Thomas, U.S.V.I. 00802. FOR FURTHER INFORMATION CONTACT: Mr...

  3. 77 FR 42278 - New England Fishery Management Council; Public Meeting

    Science.gov (United States)

    2012-07-18

    ... National Oceanic and Atmospheric Administration New England Fishery Management Council; Public Meeting...), Commerce. ACTION: Notice; public meeting. SUMMARY: The New England Fishery Management Council's (Council... meeting will be held at the Sheraton Harborside Hotel, 250 Market Street, Portsmouth, NH 03801; telephone...

  4. Elements of a Knowledge Management Guide for Public Sector Organizations

    Science.gov (United States)

    Harris, Mark Cameron

    2013-01-01

    This study explored the factors that are critical to the success of public (government) sector knowledge management initiatives and the lessons from private sector knowledge management and organizational learning that apply in the public sector. The goal was to create a concise guide, based on research-validated success factors, to aid government…

  5. 78 FR 32623 - Caribbean Fishery Management Council; Public Meetings

    Science.gov (United States)

    2013-05-31

    ... National Oceanic and Atmospheric Administration RIN 0648-XC706 Caribbean Fishery Management Council; Public... (NOAA), Commerce. ACTION: Notice of public meetings. SUMMARY: The Caribbean Fishery Management Council's Scientific and ] Statistical Committee (SSC) will hold meetings. DATES: The SSC meetings will be held June...

  6. 78 FR 64200 - Caribbean Fishery Management Council; Public Meetings

    Science.gov (United States)

    2013-10-28

    ... National Oceanic and Atmospheric Administration RIN 0648-XC933 Caribbean Fishery Management Council; Public... (NOAA), Commerce. ACTION: Notice of public meetings. SUMMARY: The Caribbean Fishery Management Council's (Council) Scientific and Statistical Committee (SSC) will hold meetings. DATES: The SSC meetings will...

  7. 77 FR 20613 - New England Fishery Management Council; Public Meeting

    Science.gov (United States)

    2012-04-05

    ... National Oceanic and Atmospheric Administration RIN 0648-XB129 New England Fishery Management Council... Administration (NOAA), Commerce. ACTION: Notice of cancellation of a public meeting. SUMMARY: The New England Fishery Management Council (Council) has cancelled the public meeting of its Scientific and...

  8. Vaksamhet mot korruption och New Public Management

    Directory of Open Access Journals (Sweden)

    Karl Loxbo

    2012-01-01

    Full Text Available

    Eftersom organisationsförändringar i New Public Management filosofins fotspår har blivit allt vanligare i svenska kommuner, ofta med oklara regler som följd, menar flera forskare att en ny riskzon för korruption kan ha uppstått också i det traditionellt icke-korrupta Sverige. Genom att påbörja den empiriska kartläggningen av hur korruption upplevs bland politiskt ansvariga i Sveriges kommuner syftar artikeln till att granska om det finns någon grund för denna misstanke. Resultaten visar att den formaliserade uppmärksamheten kring korruption är långt mer utvecklad i de kommuner som tidigt införde kundvalssystem. Sambandet mellan en högre grad av formaliserad uppmärksamhet mot korruption och införandet av kundvalssystem håller också med kontroll för kommunens befolkningsstorlek. Trots att artikeln inte kan säga något om den faktiska utbredningen av korruption i svenska kommuner visar resultaten att politiker och tjänstemän i kommuner som mer helhjärtat än andra har genomfört långtgående marknadsreformer själva tycks bedöma att det finns en risk för korruption. Följaktligen ger resultaten indikationer om att formella åtgärder mot korruption i svenska kommuner är mer omfattande där teoretiska förväntningar gör gällande att riskerna är mest utbredda.

  9. Management challenges at the intersection of public policy environments and strategic decision making in public hospitals.

    Science.gov (United States)

    Longest, Beaufort B

    2012-01-01

    Hospitals in the United States are heavily impacted by public policies that affect them. For example, Medicare and Medicaid programs account for more than half the revenue in most of the nation's almost 5,000 community hospitals, including the almost 1,100 public hospitals controlled by state and local governments (American Hospital Association, 2012). The public hospitals are especially closely aligned with and controlled by governmental entities compared with hospitals with other kinds of sponsorship. This article addresses the management challenges at the intersection of the strategic management of public hospitals and their public policy environments. Public hospitals are complicated entities designed not only to provide health services but also in many cases to play key roles in health-related research and education and to play important general economic development roles in their communities. The multi-faceted strategic decision making in these organizations is as heavily affected by their public policy environments as by their business, demographic, technological or other external environments. Effectively managing the intersection of their public policy environments and their strategic management is indeed vital for contemporary public hospitals. This article is intended to clarify certain aspects of this intersection through a description and model of the strategic activity in public hospitals and the connection between this activity and their external environments. Specific attention is focused on the concept of public policy environments and their features. Attention is also given to how managers can assess public policy environments and incorporate the results into strategic activities.

  10. Oncogenic kinase NPM/ALK induces expression of HIF1α mRNA.

    Science.gov (United States)

    Marzec, M; Liu, X; Wong, W; Yang, Y; Pasha, T; Kantekure, K; Zhang, P; Woetmann, A; Cheng, M; Odum, N; Wasik, M A

    2011-03-17

    The mechanisms of malignant cell transformation mediated by the oncogenic anaplastic lymphoma kinase (ALK) tyrosine kinase remain only partially understood. In this study, we report that T-cell lymphoma (TCL) cells carrying the nucleophosmin (NPM)/ALK fusion protein (ALK+ TCL) strongly express hypoxia-induced factor 1α (HIF1α) mRNA, even under normoxic conditions, and markedly upregulate HIF1α protein expression under hypoxia. HIF1α expression is strictly dependent on the expression and enzymatic activity of NPM/ALK, as shown in BaF3 cells transfected with wild-type NPM/ALK and kinase-inactive NPM/ALK K210R mutant and by the inhibition of the NPM/ALK function in ALK+ TCL cells by a small-molecule ALK inhibitor. NPM/ALK induces HIF1α expression by upregulating its gene transcription through its key signal transmitter signal transducer and activator of transcription 3 (STAT3), which binds to the HIF1α gene promoter as shown by the chromatin immunoprecipitation assay and is required for HIF1α gene expression as demonstrated by its small interfering RNA-mediated depletion. In turn, depletion of HIF1α increases mammalian target of rapamycin complex 1 activation, cell growth and proliferation and decreases vascular endothelial growth factor synthesis. These results identify a novel cell-transforming property of NPM/ALK, namely its ability to induce the expression of HIF1α, a protein with an important role in carcinogenesis. These results also provide another rationale to therapeutically target NPM/ALK and STAT3 in ALK+ TCL.

  11. PUBLIC SECTOR INTER-INSTITUTIONAL COMBINATIONS - AN INTERDISCIPLINARY PERSPECTIVE

    Directory of Open Access Journals (Sweden)

    Ina MITU

    2014-11-01

    Full Text Available The purpose of this paper is to analyze the recent research litarature regarding public sector inter-institutional combinations. Based upon a sample of 51 articles published in 2010-2013 in four databases (Science Direct, Springer Link, Wiley Online Library and Sage, this study summarizes and analyses the approaches found. In the light of an in-depth empirical research the article looks at the issues raised by the public sector inte-institutional combinationsbygrouping the sample usingthe folowing criteria: year of publication, research methodology, field, the mentioning of New Public Management(NPM concept, theory and geographical area studied.The results reveal the fact that the predominant research methods used are: case study and statistical methods. The vast majority of papers analyze public institutions combinations of local public administration and investigate public sector combinations from Europe. Additionally, the majority of studies from the sample mention the concept of NPM and the institutional theory is mentioned in five articles.

  12. Pakistan - Public Expenditure Management : Strategic Issues and Reform Agenda

    OpenAIRE

    World Bank

    2004-01-01

    This report focuses principally on three key dimensions of better public expenditure management in Pakistan. First, it is paramount to continue financial discipline and reduce the overall size of the public sector deficit, including the sizable losses of public enterprises. The modest progress made in reducing the government's fiscal deficit during the past few years has been undermined by...

  13. Electronic Publications and Collection Management -- Issues to Consider

    Science.gov (United States)

    Grothkopf, Uta

    Electronic publications affect virtually all areas of library collection management. Previously, clearly distinguished work areas could be defined, including Acquisitions, Processing, Using/Making Available, and Archiving of publications. These areas must be modified in the digital environment to remain effective. Based on the traditional model of library collection management, the article gives an overview of issues librarians should consider when dealing with electronic publications.

  14. NPM and BRG1 Mediate Transcriptional Resistance to Retinoic Acid in Acute Promyelocytic Leukemia.

    Science.gov (United States)

    Nichol, Jessica N; Galbraith, Matthew D; Kleinman, Claudia L; Espinosa, Joaquín M; Miller, Wilson H

    2016-03-29

    Perturbation in the transcriptional control of genes driving differentiation is an established paradigm whereby oncogenic fusion proteins promote leukemia. From a retinoic acid (RA)-sensitive acute promyelocytic leukemia (APL) cell line, we derived an RA-resistant clone characterized by a block in transcription initiation, despite maintaining wild-type PML/RARA expression. We uncovered an aberrant interaction among PML/RARA, nucleophosmin (NPM), and topoisomerase II beta (TOP2B). Surprisingly, RA stimulation in these cells results in enhanced chromatin association of the nucleosome remodeler BRG1. Inhibition of NPM or TOP2B abrogated BRG1 recruitment. Furthermore, NPM inhibition and targeting BRG1 restored differentiation when combined with RA. Here, we demonstrate a role for NPM and BRG1 in obstructing RA differentiation and implicate chromatin remodeling in mediating therapeutic resistance in malignancies. NPM mutations are the most common genetic change in patients with acute leukemia (AML); therefore, our model may be applicable to other more common leukemias driven by NPM.

  15. PDGFR blockade is a rational and effective therapy for NPM-ALK-driven lymphomas.

    Science.gov (United States)

    Laimer, Daniela; Dolznig, Helmut; Kollmann, Karoline; Vesely, Paul W; Schlederer, Michaela; Merkel, Olaf; Schiefer, Ana-Iris; Hassler, Melanie R; Heider, Susi; Amenitsch, Lena; Thallinger, Christiane; Staber, Philipp B; Simonitsch-Klupp, Ingrid; Artaker, Matthias; Lagger, Sabine; Turner, Suzanne D; Pileri, Stefano; Piccaluga, Pier Paolo; Valent, Peter; Messana, Katia; Landra, Indira; Weichhart, Thomas; Knapp, Sylvia; Shehata, Medhat; Todaro, Maria; Sexl, Veronika; Höfler, Gerald; Piva, Roberto; Medico, Enzo; Ruggeri, Bruce A; Cheng, Mangeng; Eferl, Robert; Egger, Gerda; Penninger, Josef M; Jaeger, Ulrich; Moriggl, Richard; Inghirami, Giorgio; Kenner, Lukas

    2012-11-01

    Anaplastic large cell lymphoma (ALCL) is an aggressive non-Hodgkin's lymphoma found in children and young adults. ALCLs frequently carry a chromosomal translocation that results in expression of the oncoprotein nucleophosmin-anaplastic lymphoma kinase (NPM-ALK). The key molecular downstream events required for NPM-ALK-triggered lymphoma growth have been only partly unveiled. Here we show that the activator protein 1 family members JUN and JUNB promote lymphoma development and tumor dissemination through transcriptional regulation of platelet-derived growth factor receptor-β (PDGFRB) in a mouse model of NPM-ALK-triggered lymphomagenesis. Therapeutic inhibition of PDGFRB markedly prolonged survival of NPM-ALK transgenic mice and increased the efficacy of an ALK-specific inhibitor in transplanted NPM-ALK tumors. Notably, inhibition of PDGFRA and PDGFRB in a patient with refractory late-stage NPM-ALK(+) ALCL resulted in rapid, complete and sustained remission. Together, our data identify PDGFRB as a previously unknown JUN and JUNB target that could be a highly effective therapy for ALCL.

  16. AKT regulates NPM dependent ARF localization and p53mut stability in tumors.

    Science.gov (United States)

    Hamilton, Garth; Abraham, Aswin G; Morton, Jennifer; Sampson, Oliver; Pefani, Dafni E; Khoronenkova, Svetlana; Grawenda, Anna; Papaspyropoulos, Angelos; Jamieson, Nigel; McKay, Colin; Sansom, Owen; Dianov, Grigory L; O'Neill, Eric

    2014-08-15

    Nucleophosmin (NPM) is known to regulate ARF subcellular localization and MDM2 activity in response to oncogenic stress, though the precise mechanism has remained elusive. Here we describe how NPM and ARF associate in the nucleoplasm to form a MDM2 inhibitory complex. We find that oligomerization of NPM drives nucleolar accumulation of ARF. Moreover, the formation of NPM and ARF oligomers antagonizes MDM2 association with the inhibitory complex, leading to activation of MDM2 E3-ligase activity and targeting of p53. We find that AKT phosphorylation of NPM-Ser48 prevents oligomerization that results in nucleoplasmic localization of ARF, constitutive MDM2 inhibition and stabilization of p53. We also show that ARF promotes p53 mutant stability in tumors and suppresses p73 mediated p21 expression and senescence. We demonstrate that AKT and PI3K inhibitors may be effective in treatment of therapeutically resistant tumors with elevated AKT and carrying gain of function mutations in p53. Our results show that the clinical candidate AKT inhibitor MK-2206 promotes ARF nucleolar localization, reduced p53(mut) stability and increased sensitivity to ionizing radiation in a xenograft model of pancreatic cancer. Analysis of human tumors indicates that phospho-S48-NPM may be a useful biomarker for monitoring AKT activity and in vivo efficacy of AKT inhibitor treatment. Critically, we propose that combination therapy involving PI3K-AKT inhibitors would benefit from a patient stratification rationale based on ARF and p53(mut) status.

  17. New Quantitative Method to Identify NPM1 Mutations in Acute Myeloid Leukaemia

    Directory of Open Access Journals (Sweden)

    Sarah Huet

    2013-01-01

    Full Text Available Somatic mutations in the NPM1 gene, which encodes for nucleophosmin, have been reported to be the most frequent genetic abnormalities found in acute myeloid leukaemia (AML. Their identification and quantification remain crucial for the patients’ residual disease monitoring. We investigated a new method that could represent a novel reliable alternative to sequencing for its identification. This method was based on high-resolution melting analysis in order to detect mutated patients and on an allele-specific oligonucleotide real-time quantitative polymerase chain reaction (ASO-RQ-PCR for the identification and quantification of the transcripts carrying NPM1 mutations (NPM1m. Few patients carrying known NPM1m enabled us to set up a table with the different primers’ ΔCT values, identifying a profile for each mutation type. We then analysed a series of 337 AML patients' samples for NPM1 mutational status characterization and confirmed the ASO-RQ-PCR results by direct sequencing. We identified some mutations in 86 samples, and the results were fully correlated in 100% of the 36 sequenced samples. We also detected other rare NPM1m in two samples, that we confirmed by direct sequencing. This highly specific method provides a novel quick, useful, and costless tool, easy to use in routine practice.

  18. STRATEGIC MANAGEMENT OF TECHNOLOGY IN PUBLIC ...

    African Journals Online (AJOL)

    hi-tech

    2004-06-01

    Jun 1, 2004 ... new challenges in management of health care services for both developing and ... deploy, manage and assess new technologies, and also the development of strategies ..... Washington: Space Labs. Inc. 1993. 4. Kachieng'a ...

  19. Public debt management before, during and after the crisis

    Directory of Open Access Journals (Sweden)

    Ana Andabaka Badurina

    2012-03-01

    Full Text Available During the financial and economic crisis, the public debt ratio in the European Union increased significantly, and public debt management had to be carried out in a completely new and unfavorable environment. The authors of this paper explore the changes in public debt management during and after the crisis. They describe the way in which three members of the Union – the Netherlands, Ireland and Hungary – dealt with the challenge of government financing during the crisis. These three countries were chosen because they all had a comparatively welldeveloped public debt management system before the crisis, and also due to the fact that during the crisis those responsible for public debt management pursued a policy of active accommodation to current market circumstances. Therefore, these case studies can illustrate the capacity of public debt management to contribute to the prevention of a sovereign debt crisis. In the conclusion, the authors give an overview of public debt management in Croatia in the period of the crisis and compare it with public debt management in the three countries whose experiences are presented in the paper.

  20. The Public and Nuclear Waste Management.

    Science.gov (United States)

    Zinberg, Dorothy

    1979-01-01

    Discusses the public's negative attitude towards nuclear energy development. Explains the perceptions for the nuclear waste disposal problem, and the concern for the protection of the environment. (GA)

  1. Total Quality Management Plan: Office of Public Affairs

    Science.gov (United States)

    1989-07-01

    AND DATES COVERED I July 1989 4. TITLE AND SUBTITLE 5. FUNDING NUMBERS Total Quality Management Plan Office of Public Affairs 6. AUTHOR(S) 7...ANSI %to 09-10 2g6. 1O2 TOTAL QUALITY MANAGEMENT PLAN Defense Logistics Agency Office of Public Affairs Ace!;son For NT-S G":I DTTC T ,’ Ju:.. t if...12 CONCEPTS We recognize that the following concepts are vital to total quality management (TQM) as it applies specifically

  2. Applying the ecosystem services concept to public land management

    Science.gov (United States)

    Jeffrey D. Kline; Marisa J. Mazzota; Thomas A. Spies; Mark E. Harmon

    2013-01-01

    We examine challenges and opportunities involved in applying ecosystem services to public land management with an emphasis on national forests in the United States. We review historical forest management paradigms and related economic approaches, outline a conceptual framework defining the informational needs of forest managers, and consider the feasibility of its...

  3. 77 FR 21752 - New England Fishery Management Council; Public Meeting

    Science.gov (United States)

    2012-04-11

    ... Administration (NOAA), Commerce. ACTION: Notice of a public meeting. SUMMARY: The New England Fishery Management... National Oceanic and Atmospheric Administration RIN 0648-XB153 New England Fishery Management Council...: (860) 572-0328. Council address: New England Fishery Management Council, 50 Water Street, Mill...

  4. 75 FR 43928 - New England Fishery Management Council; Public Meeting

    Science.gov (United States)

    2010-07-27

    ... Administration (NOAA), Commerce ACTION: Notice; public meeting. SUMMARY: The New England Fishery Management... National Oceanic and Atmospheric Administration RIN 0648-XX80 New England Fishery Management Council...-7200; fax: (781) 289-3176. Council address: New England Fishery Management Council, 50 Water...

  5. 76 FR 48807 - New England Fishery Management Council; Public Meeting

    Science.gov (United States)

    2011-08-09

    ... Administration (NOAA), Commerce. ACTION: Notice; public meeting. SUMMARY: The New England Fishery Management... National Oceanic and Atmospheric Administration RIN 0648-XA623 New England Fishery Management Council...: (401) 861-8002. Council address: New England Fishery Management Council, 50 Water Street, Mill...

  6. 78 FR 11630 - New England Fishery Management Council; Public Meeting

    Science.gov (United States)

    2013-02-19

    ... Administration (NOAA), Commerce. ACTION: Notice; public meeting. SUMMARY: The New England Fishery Management... National Oceanic and Atmospheric Administration RIN 0648-XC504 New England Fishery Management Council... address: New England Fishery Management Council, 50 Water Street, Mill 2, Newburyport, MA 01950....

  7. 75 FR 32375 - New England Fishery Management Council; Public Meeting

    Science.gov (United States)

    2010-06-08

    ... Administration (NOAA), Commerce. ACTION: Notice of a public meeting. SUMMARY: The New England Fishery Management... National Oceanic and Atmospheric Administration RIN 0648-XW84 New England Fishery Management Council...; telephone: (207) 775-5411; fax: (207) 775- 2872. Council address: New England Fishery Management Council,...

  8. 75 FR 74008 - New England Fishery Management Council; Public Meeting

    Science.gov (United States)

    2010-11-30

    ... Administration (NOAA), Commerce. ACTION: Notice; public meeting. SUMMARY: The New England Fishery Management... National Oceanic and Atmospheric Administration RIN 0648-XA065 New England Fishery Management Council... address: New England Fishery Management Council, 50 Water Street, Mill 2, Newburyport, MA 01950....

  9. 76 FR 44577 - New England Fishery Management Council; Public meeting

    Science.gov (United States)

    2011-07-26

    ... Administration (NOAA), Commerce. ACTION: Notice; Public meeting. ] SUMMARY: The New England Fishery Management... National Oceanic and Atmospheric Administration RIN 0648-XA598 New England Fishery Management Council...) 750-7991. Council address: New England Fishery Management Council, 50 Water Street, Mill...

  10. 78 FR 30868 - New England Fishery Management Council; Public Meeting

    Science.gov (United States)

    2013-05-23

    ... Administration (NOAA), Commerce. ACTION: Notice; public meeting. SUMMARY: The New England Fishery Management... National Oceanic and Atmospheric Administration RIN 0648-XC692 New England Fishery Management Council...; telephone: (401) 421-0700; fax: (401) 455-3040. Council address: New England Fishery Management Council,...

  11. 76 FR 17381 - New England Fishery Management Council; Public Meeting

    Science.gov (United States)

    2011-03-29

    ... Administration (NOAA), Commerce. ACTION: Notice; public meeting. SUMMARY: The New England Fishery Management... National Oceanic and Atmospheric Administration RIN 0648-XA325 New England Fishery Management Council...; fax: (508) 339- 1040. Council address: New England Fishery Management Council, 50 Water Street, Mill...

  12. 76 FR 4870 - New England Fishery Management Council; Public Meeting

    Science.gov (United States)

    2011-01-27

    ... Administration (NOAA), Commerce. ACTION: Notice of a public meeting. SUMMARY: The New England Fishery Management... National Oceanic and Atmospheric Administration RIN 0648-XA181 New England Fishery Management Council... INFORMATION CONTACT: Paul J. Howard, Executive Director, New England Fishery Management Council;...

  13. 78 FR 48419 - New England Fishery Management Council; Public Meeting

    Science.gov (United States)

    2013-08-08

    ... Administration (NOAA), Commerce. ACTION: Notice; public meeting. SUMMARY: The New England Fishery Management... National Oceanic and Atmospheric Administration RIN 0648-XC796 New England Fishery Management Council...: (978) 535-8283. Council address: New England Fishery Management Council, 50 Water Street, Mill...

  14. 75 FR 1752 - New England Fishery Management Council; Public Meeting

    Science.gov (United States)

    2010-01-13

    ... Administration (NOAA), Commerce. ACTION: Notice of a public meeting. SUMMARY: The New England Fishery Management... National Oceanic and Atmospheric Administration RIN 0648-XT67 New England Fishery Management Council...; telephone: (603) 431-2300 and fax: (603) 433-5649. Council address: New England Fishery Management...

  15. 77 FR 5774 - New England Fishery Management Council; Public Meeting

    Science.gov (United States)

    2012-02-06

    ... Administration (NOAA), Commerce. ACTION: Notice; public meeting. SUMMARY: The New England Fishery Management... National Oceanic and Atmospheric Administration RIN 0648-XA980 New England Fishery Management Council...: (603) 431-2300; fax: (603) 433-5649. Council Address: New England Fishery Management Council, 50...

  16. 78 FR 14981 - New England Fishery Management Council; Public Meeting

    Science.gov (United States)

    2013-03-08

    ... Administration (NOAA), Commerce. ACTION: Notice; public meeting. SUMMARY: The New England Fishery Management... National Oceanic and Atmospheric Administration RIN 0648-XC547 New England Fishery Management Council.... Council address: New England Fishery Management Council, 50 Water Street, Mill 2, Newburyport, MA...

  17. 78 FR 64480 - New England Fishery Management Council; Public Meeting

    Science.gov (United States)

    2013-10-29

    ... Administration (NOAA), Commerce. ACTION: Notice; public meeting. SUMMARY: The New England Fishery Management... National Oceanic and Atmospheric Administration RIN 0648-XC939 New England Fishery Management Council...: (401) 598-8000; fax: (401) 598-8200. ] Council address: New England Fishery Management Council,...

  18. 78 FR 71565 - New England Fishery Management Council; Public Meeting

    Science.gov (United States)

    2013-11-29

    ... Administration (NOAA), Commerce. ACTION: Notice of public meeting. SUMMARY: The New England Fishery Management... National Oceanic and Atmospheric Administration RIN 0648-XD006 New England Fishery Management Council... . ] Council address: New England Fishery Management Council, 50 Water Street, Mill 2, Newburyport, MA...

  19. 78 FR 18963 - New England Fishery Management Council; Public Meeting

    Science.gov (United States)

    2013-03-28

    ... Administration (NOAA), Commerce. ACTION: Notice; public meeting. SUMMARY: The New England Fishery Management... National Oceanic and Atmospheric Administration RIN 0648-XC594 New England Fishery Management Council...: (508) 339- 2200; fax: (508) 339-1040. Council address: New England Fishery Management Council, 50...

  20. 77 FR 15721 - New England Fishery Management Council; Public Meeting

    Science.gov (United States)

    2012-03-16

    ... Administration (NOAA), Commerce. ACTION: Notice; public meeting. SUMMARY: The New England Fishery Management... National Oceanic and Atmospheric Administration RIN0648-XB090 New England Fishery Management Council...-4306. Council address: New England Fishery Management Council, 50 Water Street, Mill 2, Newburyport,...

  1. 75 FR 78976 - New England Fishery Management Council; Public Meeting

    Science.gov (United States)

    2010-12-17

    ... Administration (NOAA), Commerce. ACTION: Notice; public meeting. SUMMARY: The New England Fishery Management... National Oceanic and Atmospheric Administration RIN 0648-XA092 New England Fishery Management Council...: (617) 569-5250; fax: (617) 561-0971. Council address: New England Fishery Management Council, 50...

  2. 77 FR 64491 - New England Fishery Management Council; Public Meeting

    Science.gov (United States)

    2012-10-22

    ... Administration (NOAA), Commerce. ACTION: Notice; public meeting. SUMMARY: The New England Fishery Management... National Oceanic and Atmospheric Administration RIN 0648-XC306 New England Fishery Management Council...-3176. Council address: New England Fishery Management Council, 50 Water Street, Mill 2, Newburyport,...

  3. 75 FR 78680 - New England Fishery Management Council; Public Hearings

    Science.gov (United States)

    2010-12-16

    ... Hearing. SUMMARY: The New England Fishery Management Council (Council) has rescheduled a public hearing to... National Oceanic and Atmospheric Administration RIN 0648-XA091 New England Fishery Management Council... INFORMATION CONTACT: Paul J. Howard, Executive Director, New England Fishery Management Council;...

  4. 75 FR 11846 - New England Fishery Management Council; Public Meeting

    Science.gov (United States)

    2010-03-12

    ... Administration (NOAA), Commerce. ACTION: Notice; public meeting. SUMMARY: The New England Fishery Management... National Oceanic and Atmospheric Administration RIN 0648-XV06 New England Fishery Management Council...; telephone: (617) 385-4000; fax: (617) 385-4001. Council address: New England Fishery Management Council,...

  5. 75 FR 27990 - New England Fishery Management Council; Public Meeting

    Science.gov (United States)

    2010-05-19

    ... Administration (NOAA), Commerce. ACTION: Notice of a public meeting. SUMMARY: The New England Fishery Management... National Oceanic and Atmospheric Administration RIN 0648-XW50 New England Fishery Management Council...) 421-8006. Council address: New England Fishery Management Council, 50 Water Street, Mill...

  6. 78 FR 77658 - New England Fishery Management Council; Public Meeting

    Science.gov (United States)

    2013-12-24

    ... Administration (NOAA), Commerce. ACTION: Notice; public meeting. SUMMARY: The New England Fishery Management... National Oceanic and Atmospheric Administration RIN 0648-XD045 New England Fishery Management Council...: New England Fishery Management Council, 50 Water Street, Mill 2, Newburyport, MA 01950. FOR...

  7. 77 FR 52314 - New England Fishery Management Council; Public Meeting

    Science.gov (United States)

    2012-08-29

    ... Administration (NOAA), Commerce. ACTION: Notice; public meeting. SUMMARY: The New England Fishery Management... National Oceanic and Atmospheric Administration RIN 0648-XC199 New England Fishery Management Council...) 634-2001. Council address: New England Fishery Management Council, 50 Water Street, Mill...

  8. 78 FR 13326 - New England Fishery Management Council; Public Meeting

    Science.gov (United States)

    2013-02-27

    ... Administration (NOAA), Commerce ACTION: Notice; public meeting. ] SUMMARY: The New England Fishery Management... National Oceanic and Atmospheric Administration RIN 0648-XC520 New England Fishery Management Council... address: New England Fishery Management Council, 50 Water Street, Mill 2, Newburyport, MA 01950....

  9. 77 FR 16540 - New England Fishery Management Council; Public Meeting

    Science.gov (United States)

    2012-03-21

    ... Administration (NOAA), Commerce ACTION: Notice; public meeting. SUMMARY: The New England Fishery Management... National Oceanic and Atmospheric Administration RIN: 0648-XB097 New England Fishery Management Council...-4306. Council address: New England Fishery Management Council, 50 Water Street, Mill 2, Newburyport,...

  10. 77 FR 58983 - New England Fishery Management Council; Public Meeting

    Science.gov (United States)

    2012-09-25

    ... Administration (NOAA), Commerce. ACTION: Notice of a public meeting. SUMMARY: The New England Fishery Management... National Oceanic and Atmospheric Administration RIN 0648-XC250 New England Fishery Management Council...) 926-6762; fax: (603) 926-2002. Council address: New England Fishery Management Council, 50...

  11. 76 FR 9756 - New England Fishery Management Council; Public Meeting

    Science.gov (United States)

    2011-02-22

    ... Administration (NOAA), Commerce. ACTION: Notice; public meeting. SUMMARY: The New England Fishery Management... National Oceanic and Atmospheric Administration RIN 0648-XA234 New England Fishery Management Council...-2300; fax: (603) 433-5649. Council address: New England Fishery Management Council, 50 Water...

  12. 75 FR 11845 - New England Fishery Management Council; Public Meeting

    Science.gov (United States)

    2010-03-12

    ... Administration (NOAA), Commerce. ACTION: Notice; public meeting. SUMMARY: The New England Fishery Management... National Oceanic and Atmospheric Administration RIN 0648-XV07 New England Fishery Management Council...; telephone: (617) 385-4000; fax: (617) 385-4001. Council address: New England Fishery Management Council,...

  13. 77 FR 75614 - New England Fishery Management Council; Public Meeting

    Science.gov (United States)

    2012-12-21

    ... Administration (NOAA), Commerce. ACTION: Notice; public meeting. SUMMARY: The New England Fishery Management... National Oceanic and Atmospheric Administration RIN 0648-XC411 New England Fishery Management Council...; telephone: (207) 775-2311; fax: (207) 772-4017. Council address: New England Fishery Management Council,...

  14. 77 FR 15720 - New England Fishery Management Council; Public Meeting

    Science.gov (United States)

    2012-03-16

    ... Administration (NOAA), Commerce. ACTION: Notice; public meeting. SUMMARY: The New England Fishery Management... National Oceanic and Atmospheric Administration RIN 0648-XB092 New England Fishery Management Council...-3000; fax: (401) 732-9309. Council address: New England Fishery Management Council, 50 Water...

  15. 78 FR 11820 - New England Fishery Management Council; Public Meeting

    Science.gov (United States)

    2013-02-20

    ... Administration (NOAA), Commerce. ACTION: Notice; public meeting. SUMMARY: The New England Fishery Management... National Oceanic and Atmospheric Administration RIN 0648-XC514 New England Fishery Management Council.... Council address: New England Fishery Management Council, 50 Water Street, Mill 2, Newburyport, MA...

  16. 76 FR 28214 - New England Fishery Management Council; Public Meeting

    Science.gov (United States)

    2011-05-16

    ... Administration (NOAA), Commerce. ACTION: Notice; public meeting. SUMMARY: The New England Fishery Management... National Oceanic and Atmospheric Administration RIN 0648-XA437 New England Fishery Management Council...; telephone: (603) 436-7600; fax: (603) 436-7600. Council address: New England Fishery Management Council,...

  17. 78 FR 48420 - New England Fishery Management Council; Public Meeting

    Science.gov (United States)

    2013-08-08

    ... Administration (NOAA), Commerce. ACTION: Notice; public meeting. SUMMARY: The New England Fishery Management... National Oceanic and Atmospheric Administration RIN 0648-XC788 New England Fishery Management Council.... Council Address: New England Fishery Management Council, 50 Water Street, Mill 2, Newburyport, MA...

  18. 76 FR 71939 - New England Fishery Management Council; Public Meeting

    Science.gov (United States)

    2011-11-21

    ... Administration (NOAA), Commerce. ACTION: Notice; public meeting. SUMMARY: The New England Fishery Management... National Oceanic and Atmospheric Administration RIN 0648-XA837 New England Fishery Management Council...-4001. Council address: New England Fishery Management Council, 50 Water Street, Mill 2, Newburyport,...

  19. 78 FR 64199 - New England Fishery Management Council; Public Meeting

    Science.gov (United States)

    2013-10-28

    ... Administration (NOAA), Commerce. ACTION: Notice; public meeting. SUMMARY: The New England Fishery Management... National Oceanic and Atmospheric Administration RIN 0648-XC936 New England Fishery Management Council...; telephone: (401) 598-8000; fax: (401) 598-8200. Council Address: New England Fishery Management Council,...

  20. 77 FR 16211 - New England Fishery Management Council; Public Meeting

    Science.gov (United States)

    2012-03-20

    ... Administration (NOAA), Commerce. ACTION: Notice; public meeting. SUMMARY: The New England Fishery Management... National Oceanic and Atmospheric Administration RIN 0648-XB091 New England Fishery Management Council.... Council address: New England Fishery Management Council, 50 Water Street, Mill 2, Newburyport, MA...

  1. 77 FR 19231 - New England Fishery Management Council; Public Meeting

    Science.gov (United States)

    2012-03-30

    ... Administration (NOAA), Commerce. ACTION: Notice; public meeting. SUMMARY: The New England Fishery Management... National Oceanic and Atmospheric Administration RIN 0648-XB129 New England Fishery Management Council...: (401) 861-8002. Council address: New England Fishery Management Council, 50 Water Street, Mill...

  2. 77 FR 75615 - New England Fishery Management Council; Public Meeting

    Science.gov (United States)

    2012-12-21

    ... Administration (NOAA), Commerce. ACTION: Notice; public meeting. SUMMARY: The New England Fishery Management... National Oceanic and Atmospheric Administration RIN 0648-XC410 New England Fishery Management Council...; telephone: (207) 775-2311; fax: (207) 772-4017. Council address: New England Fishery Management Council,...

  3. 77 FR 64490 - New England Fishery Management Council; Public Meeting

    Science.gov (United States)

    2012-10-22

    ... Administration (NOAA), Commerce. ACTION: Notice; public meeting. SUMMARY: The New England Fishery Management... National Oceanic and Atmospheric Administration RIN 0648-XC305 New England Fishery Management Council...-3176. Council address: New England Fishery Management Council, 50 Water Street, Mill 2, Newburyport,...

  4. 76 FR 543 - New England Fishery Management Council; Public Meeting

    Science.gov (United States)

    2011-01-05

    ... Administration (NOAA), Commerce. ACTION: Notice of a public meeting. SUMMARY: The New England Fishery Management... National Oceanic and Atmospheric Administration RIN 0648-XA127 New England Fishery Management Council... INFORMATION CONTACT: Paul J. Howard, Executive Director, New England Fishery Management Council;...

  5. 78 FR 53730 - New England Fishery Management Council; Public Meeting

    Science.gov (United States)

    2013-08-30

    ... Administration (NOAA), Commerce. ACTION: Notice; public meetings. SUMMARY: The New England Fishery Management... National Oceanic and Atmospheric Administration RIN 0648-XC842 New England Fishery Management Council...) 431-8000; fax: (603) 501-3733. Council address: New England Fishery Management Council, 50...

  6. 78 FR 14982 - New England Fishery Management Council; Public Meeting

    Science.gov (United States)

    2013-03-08

    ... Administration (NOAA), Commerce. ACTION: Notice; public meeting. SUMMARY: The New England Fishery Management... National Oceanic and Atmospheric Administration RIN 0648-XC546 New England Fishery Management Council...-4650. Council address: New England Fishery Management Council, 50 Water Street, Mill 2, Newburyport,...

  7. 76 FR 48806 - New England Fishery Management Council; Public Meeting

    Science.gov (United States)

    2011-08-09

    ... Administration (NOAA), Commerce. ACTION: Notice; public meeting. SUMMARY: The New England Fishery Management... National Oceanic and Atmospheric Administration RIN 0648-XA621 New England Fishery Management Council...; fax: (401) 861-8002. Council address: New England Fishery Management Council, 50 Water Street, Mill...

  8. Collaborative Public Management and Collaborative Governance: Conceptual Similarities and Differences

    Directory of Open Access Journals (Sweden)

    Naim Kapucu

    2009-05-01

    Full Text Available There has been considerable interest among Public Administration scholars in collaborative public management and governance. However, there is a need for conceptual analysis of the two terms which share common aspects and differ essentially in scope and substance. We found that collaborative public management has a more local approach and focuses on the substance of collaboration practiced to solve societal problems and reach community goals at the organizational level. On the other hand, widely researched in management, political science, and public administration disciplines, collaborative governance has a global scope and focuses on both substance and process of collaboration in effectively solving societal problems with improved structures of nonhierarchical and decentralized institutions and mechanisms of citizen participation both through partnership projects and e-governance tools. The paper contributes to the better understanding of collaborative public management and collaborative governance with implications for both future research and practice.

  9. Strategic Public Management - Selected Experiences with BSC Implementation

    Directory of Open Access Journals (Sweden)

    Milan PŮČEK

    2014-02-01

    Full Text Available Elements associated with modern approaches towards public management have been gaining ground in various forms in the Czech public administration, especially in the last decade. They reflect the priorities of the public administration reform and the enhanced opportunities for co-financing the implementation of new management tools from European funds. This article summarizes the experience of strategic management, based on the analysis of secondary sources and on the experience of one of the authors who has worked as manager in several public administration/public sector institutions. In the practical part, the article focuses on the potential and limits of implementation of the Balanced Scorecard using the practical experience together with the implementation of this instrument at the level of city and ministry.

  10. Public health response to striking solid waste management.

    Science.gov (United States)

    Murti, Michelle; Ayre, Reg; Shapiro, Howard; de Burger, Ron

    2011-10-01

    In 2009, the City of Toronto, Ontario, Canada, experienced a six-week labor disruption involving 24,000 city workers that included solid waste and public health employees. In an attempt to control illegal dumping and to manage garbage storage across the city during this period, 24 temporary garbage storage sites were established by the city (mostly in local parks) for residents to dispose of their household waste. No other municipality in North America has attempted to operate this many temporary sites for this long a period. Management and nonunion staff from Healthy Environments in Toronto Public Health performed daily inspections, responded to community questions, issued public health orders, and worked closely with Solid Waste Management and the Ministry of the Environment to actively manage the public health concerns associated with these sites. This intensive oversight mitigated public health risks to the community and facilitated an effective, safe solution to the temporary garbage storage problem.

  11. Public meetings on nuclear waste management: their function and organization

    Energy Technology Data Exchange (ETDEWEB)

    Duvernoy, E.G.; Marcus, A.A.; Overcast, T.; Schilling, A.H.

    1981-05-01

    This report focuses on public meetings as a vehicle for public participation in nuclear waste management. The nature of public meetings is reviewed and the functions served by meetings highlighted. The range of participants and their concerns are addressed, including a review of the participants from past nuclear waste management meetings. A sound understanding of the expected participants allows DOE to tailor elements of the meeting, such as notification, format, and agenda to accommodate the attendees. Finally, the report discusses the organization of public meetings on nuclear waste management in order to enhance the DOE's functions for such meetings. Possible structures are suggested for a variety of elements that are relevant prior to, during and after the public meeting. These suggestions are intended to supplement the DOE Public Participation Manual.

  12. Sensitivity Analysis of the NPM-ALK Signalling Network Reveals Important Pathways for Anaplastic Large Cell Lymphoma Combination Therapy

    OpenAIRE

    2016-01-01

    A large subset of anaplastic large cell lymphoma (ALCL) patients harbour a somatic aberration in which anaplastic lymphoma kinase (ALK) is fused to nucleophosmin (NPM) resulting in a constitutively active signalling fusion protein, NPM-ALK. We computationally simulated the signalling network which mediates pathological cell survival and proliferation through NPM-ALK to identify therapeutically targetable nodes through which it may be possible to regain control of the tumourigenic process. The...

  13. Integrating new values into Mongolian public management

    OpenAIRE

    Badarch, Kherlen

    2014-01-01

    This dissertation explores the socio-cultural and institutional environment of the public sector organizations of Mongolia that have strong influence on current public administration reform results. This study applies the Cultural theory and Value theory. The strong hierarchy favoring rule-bounded behavior and collectivism, fatalism accepting an authority as inevitable and uncontrollable, and individualism wishing to have control over own actions are the types of culture common in Mongolian p...

  14. Risk Management in Public Procurement Process

    OpenAIRE

    Ioana Manea; Ioana Popa

    2010-01-01

    Public procurement represents an important part of the current economy reality. Throughout the procurement process, due to the effect of the interaction among the components of the public procurement system, certain actions with significant negative effects on its optimal operation may occur. Risks may turn into certainty either because of a simple error in the development and administration of the procurement process, or because of a deliberate deviation from the existing legal provisions. T...

  15. A knock-in Npm1 mutation in mice results in myeloproliferation and implies a perturbation in hematopoietic microenvironment.

    Directory of Open Access Journals (Sweden)

    Shiu-Huey Chou

    Full Text Available Somatic Nucleophosmin (NPM1 mutation frequently occurs in acute myeloid leukemia (AML, but its role in leukemogenesis remains unclear. This study reports the first "conventional" knock-in mouse model of Npm1 mutation, which was achieved by inserting TCTG after nucleotide c.857 (c.854_857dupTCTG to mimic human mutation without any "humanized" sequence. The resultant mutant peptide differed slightly different from that in humans but exhibited cytoplasmic pulling force. Homozygous (Npm1(c+/c+ mice showed embryonic lethality before day E8.5, wheras heterozygous (Npm1(wt/c+ mice appeared healthy at birth and were fertile. Approximately 36% of Npm1(wt/c+ mice developed myeloproliferative disease (MPD with extramedullary hematopoiesis. Those Npm1(wt/c+ mice that did not develop MPD nevertheless gradually developed monocytosis and showed increased numbers of marrow myeloid precursors. This second group of Npm1(wt/c+ mice also showed compromised cobblestone area formation, suggesting pathology in the hematopoietic niche. Microarray experiments and bioinformatic analysis on mice myeloid precursor cells and 227 human samples revealed the expression of CXCR4/CXCL12-related genes was significantly suppressed in mutant cells from both mice and humans. Thus, our mouse model demonstrated that Npm1 mutation can result in MPD, but is insufficient for leukemogenesis. Perturbation of hematopoietic niche in mutant hematopoietic stem cells (implied by underrepresentation of CXCR4/CXCL12-related genes may be important in the pathogenesis of NPM1 mutations.

  16. NPM1 Gene Type A Mutation in Bulgarian Adults with Acute Myeloid Leukemia: A Single-Institution Study

    Directory of Open Access Journals (Sweden)

    Gueorgui Balatzenko

    2014-03-01

    Full Text Available OBJECTIVE: Mutations of the nucleophosmin (NPM1 gene are considered as the most frequent acute myeloid leukemia (AML- associated genetic lesion, reported with various incidences in different studies, and type A (NPM1-A is the most frequent type. However, since most series in the literature report on the features of all patients regardless of the type of mutation, NPM1-A(+ cases have not been well characterized yet. Therefore, we evaluated the prevalence of NPM1-A in Bulgarian AML patients and searched for an association with clinical and laboratory features. METHODS: One hundred and four adults (51 men, 53 women were included in the study. NPM1-A status was determined using allele-specific reverse-transcription polymerase chain reaction with co-amplification of NPM1-A and β-actin and real-time quantitative TaqMan-based polymerase chain reaction. Patients received conventional induction chemotherapy and were followed for 13.2±16.4 months. RESULTS: NPM1-A was detected in 26 (24.8% patients. NPM1-A mutation was detected in all AML categories, including in one patient with RUNX1-RUNX1T1. There were no differences associated with the NPM1-A status with respect to age, sex, hemoglobin, platelet counts, percentage of bone marrow blasts, splenomegaly, complete remission rates, and overall survival. NPM1-A(+ patients, compared to NPM1-A(- patients, were characterized by higher leukocyte counts [(75.4±81.9x109/L vs. (42.5±65.9x109/L; p=0.049], higher frequency of normal karyotype [14/18 (77.8% vs. 26/62 (41.9%; p=0.014], higher frequency of FLT3-ITD [11/26 (42.3% vs. 8/77 (10.4%; p=0.001], and lower incidence of CD34(+ [6/21 (28.8% vs. 28/45 (62.2%; p=0.017]. Within the FLT3-ITD(- group, the median overall survival of NPM1-A(- patients was 14 months, while NPM1-A(+ patients did not reach the median (p=0.10. CONCLUSION: The prevalence of NPM1-A mutation in adult Bulgarian AML patients was similar to that reported in other studies. NPM1-A(+ patients

  17. NPM1 Gene Type A Mutation in Bulgarian Adults with Acute Myeloid Leukemia: A Single-Institution Study

    Science.gov (United States)

    Balatzenko, Gueorgui; Spassov, Branimir; Stoyanov, Nikolay; Ganeva, Penka; Dikov, Tihomit; Konstantinov, Spiro; Hrischev, Vasil; Romanova, Malina; Toshkov, Stavri; Guenova, Margarita

    2014-01-01

    Objective: Mutations of the nucleophosmin (NPM1) gene are considered as the most frequent acute myeloid leukemia (AML)-associated genetic lesion, reported with various incidences in different studies, and type A (NPM1-A) is the most frequent type. However, since most series in the literature report on the features of all patients regardless of the type of mutation, NPM1-A(+) cases have not been well characterized yet. Therefore, we evaluated the prevalence of NPM1-A in Bulgarian AML patients and searched for an association with clinical and laboratory features. Materials and Methods: One hundred and four adults (51 men, 53 women) were included in the study. NPM1-A status was determined using allele-specific reverse-transcription polymerase chain reaction with co-amplification of NPM1-A and β-actin and real-time quantitative TaqMan-based polymerase chain reaction. Patients received conventional induction chemotherapy and were followed for 13.2±16.4 months. Results: NPM1-A was detected in 26 (24.8%) patients. NPM1-A mutation was detected in all AML categories, including in one patient with RUNX1-RUNX1T1. There were no differences associated with the NPM1-A status with respect to age, sex, hemoglobin, platelet counts, percentage of bone marrow blasts, splenomegaly, complete remission rates, and overall survival. NPM1-A(+) patients, compared to NPM1-A(-) patients, were characterized by higher leukocyte counts [(75.4±81.9)x109/L vs. (42.5±65.9)x109/L; p=0.049], higher frequency of normal karyotype [14/18 (77.8%) vs. 26/62 (41.9%); p=0.014], higher frequency of FLT3-ITD [11/26 (42.3%) vs. 8/77 (10.4%); p=0.001], and lower incidence of CD34(+) [6/21 (28.8%) vs. 28/45 (62.2%); p=0.017]. Within the FLT3-ITD(-) group, the median overall survival of NPM1-A(-) patients was 14 months, while NPM1-A(+) patients did not reach the median (p=0.10). Conclusion: The prevalence of NPM1-A mutation in adult Bulgarian AML patients was similar to that reported in other studies. NPM1-A

  18. The performance measurement-management divide in public health.

    Science.gov (United States)

    Schwartz, Robert; Deber, Raisa

    2016-03-01

    What happens when performance measurement and management (PMM) is applied to public health systems? This review of the experiences of high-income jurisdictions reveals considerable challenges, some familiar from the general public management literature and some more unique to public health. To aid understanding, the PMM ladder, a framework for evaluating PMM systems is developed and applied to 55 public health measurement systems from Australia, Canada, EU, New Zealand, UK and US. Results indicate that: considerable measurement is occurring for informational purposes; measurement focuses more on clinical than on population health measures; and there is relatively little use of measurement results for improving management. Results demonstrate that much public health performance measurement is restricted to population health outcomes and fails to include more proximate activity and output measures that would be more useful for managing public health organizations. There are early signs of the emergence of a new breed of public health performance measurement that attempts to do just this. The PMM ladder proved useful for assessing efforts across a range of jurisdictions. It allows policymakers and managers to easily compare their PMM efforts with others and assists researchers in assessing what happens when PMM is applied to public health.

  19. State Wildlife Management Area Boundaries - Publicly Accessible

    Data.gov (United States)

    Minnesota Department of Natural Resources — This polygon theme contains boundaries for approximately 1392 Wildlife Management Areas (WMAs) across the state covering nearly 1,288,000 acres. WMAs are part of the...

  20. Public Healthcare Organizations: Leadership or Management?

    Directory of Open Access Journals (Sweden)

    Maite Martínez-Gonzalez

    2016-11-01

    Full Text Available This article studies the type of leadership that managers are currently exercising in the Catalan health system in Catalonia. A questionnaire (MQL-5X was sent to 120 people occupying management positions in healthcare centers and hospitals as well as 14 others who also hold such positions in these healthcare centers and hospitals, were interviewed. The mixed methods research design attests that the Catalan health system is managed through a structure of simultaneous transformational and transactional leadership. However, the efficacy of this system is conditioned purely by the communicative competence that a manager may or may not possess, as the system itself makes no effort to encourage transformational leadership. Transformation leadership inspires positive change, conveys a clear vision and enhances morale, motivation and job performance. It galvanizes a team into changing their expectations and perceptions and motivates them to work towards common goals.

  1. Project Management in Development Aid Industry – Public vs. Private

    Directory of Open Access Journals (Sweden)

    Simović Dragana

    2015-02-01

    Full Text Available This article examines the relationship between the type of a development aid implementing organisation (public or private and the quality of project management in development aid. The author begins with main public administration considerations - how public aid administration is different from private and furthermore, how particular sectoral characteristics of organisations influence the quality of the management process. The article combines empirical findings on the differences between the public and private sector with a complex setting of development aid and main success factors in development aid activity, in order to determine whether for-profit or public companies are more likely to achieve better project management processes. The article identifies some indices that favorise private companies, and outlines further necessary steps that should be taken in order to broaden the argumentation and confirm or reject this assertion

  2. Role of Public Archivists and Records Managers in Governance and ...

    African Journals Online (AJOL)

    The management of public sector information sources must be evident in the ... International Monetary Fund and United Nations to completelyeradicate world ... accountability, respect for the rule of law and citizens' rights could be gauged.

  3. 75 FR 80470 - Pacific Fishery Management Council; Public Meeting

    Science.gov (United States)

    2010-12-22

    ...-2280. SUPPLEMENTARY INFORMATION: The purpose of the GMT work session is to review team roles and... (Council) Groundfish Management Team (GMT) will hold a working meeting, which is open to the public....

  4. IFRS ADOPTION AND EARNINGS MANAGEMENT IN BRAZILIAN PUBLICLY TRADED COMPANIES

    National Research Council Canada - National Science Library

    Roberto Midoguti Joia; Silvio Hiroshi Nakao

    2014-01-01

    .... This study was aimed at verifying any changes in the earnings management levels after 2010 and whether this happened in function of the full adoption of the IFRS by the Brazilian publicly traded companies...

  5. Public Use Management Plan : Mingo National Wildlife Refuge

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This management plan is an attempt to provide definition, direction, and long term guidance to the public use program at Mingo NWR. A description of the Refuge, a...

  6. METHODS AND STYLES OF MANAGEMENT IN THE PUBLIC SERVICE SYSTEM

    OpenAIRE

    R.Baskanbaeva; Zh.Tokhtabaeva; A.Zholdasbaev

    2015-01-01

    Тhis article discusses the state administration head’s styles and methods of management, the competence of the public authority, personal qualities of the head and the application of employees rotation mechanisms.

  7. Of Bureaucrats and Passionate Public Managers

    DEFF Research Database (Denmark)

    Meyer, Renate; Egger-Peitler, Isabell; Höllerer, Markus A.

    2014-01-01

    frames of reference but also social identities and vocabularies of motive for the actors in the field. In this article, we approach the expanding research on public service motivation (PSM) by employing an institutional prism. Based on an executive survey in a continental European context, we examine...... the assumption that high PSM is associated with the traditional ethos and social identity in the public sector. What we find is that a Weberian legalistic-bureaucratic logic supports neither a high attraction to policy-making nor a high level of compassion. A managerial orientation, on the other hand, entails...... significantly higher scores on these two dimensions, as well as on overall PSM....

  8. Risk Management in Public Procurement Process

    Directory of Open Access Journals (Sweden)

    Ioana Manea

    2010-12-01

    Full Text Available Public procurement represents an important part of the current economy reality. Throughout the procurement process, due to the effect of the interaction among the components of the public procurement system, certain actions with significant negative effects on its optimal operation may occur. Risks may turn into certainty either because of a simple error in the development and administration of the procurement process, or because of a deliberate deviation from the existing legal provisions. Therefore, there is an imperative for the implementation of certain risk-avoiding measures, as well as of measures aiming to reduce their negative effects in case of their occurrence.

  9. The inherent politics of quality in public park management

    DEFF Research Database (Denmark)

    Lindholst, Andrej Christian; Konijnendijk, Cecil Cornelius; Fors, Hanna

    2012-01-01

    In this paper, we highlight and illustrate the inherent politics embedded in “quality” as a concept for managing public parks. Reflecting more generic quality concepts, contemporary quality models in park management include concepts for both operational, strategic and stakeholder management as well...... managing the park organisation itself. However, quality concepts and their application through various management models include as well as exclude the access, values and worldviews of particular interests. In this way, any particular quality concept and model embeds its own politics by inherent...... allocations of ‘who gets what, when and how’. We illustrate the inherent politics by providing a case study of a widely adopted quality model for operational management that has been adopted and implemented in Denmark as part of new public management reforms. In perspective, other quality concepts and models...

  10. Management of Labor Conflicts in Public Health Organizations

    OpenAIRE

    Adriana Elena Belu; Elena Alexandra Ilinca

    2012-01-01

    The work “Management of labor conflicts in public health organizations” treats a very importantissue, of the present, with extensive and multiple implications for public health. The work can be consideredas an interdisciplinary study justified by two arguments: first, it is essential to applied research step, theknowledge and use of enshrined informational content in management literature, especially of models andmechanisms of managerial activity on the administration of human resources, mana...

  11. Social dilemmas and public range management in Nevada

    NARCIS (Netherlands)

    Kooten, van G.C.; Thomsen, P.; Hobby, T.; Eagle, A.J.

    2006-01-01

    Increasing tension in the Nevada ranch community may have had a negative impact on social capital. Social capital is important because it facilitates cooperation in resolving social dilemmas related to public range management. In this paper, we use a survey of public grazing permit holders in Nevada

  12. Public Relations Manager Involvement in Strategic Issue Diagnosis.

    Science.gov (United States)

    Lauzen, Martha M.

    1995-01-01

    Reports on an exploratory study that seeks to build theoretical understanding of how public relations practitioner involvement in one type of strategic organizational decision making--strategic issue diagnosis--is related to shared values with top management, diagnosis accuracy, strategy pursued, and the power of the public relations function. (TB)

  13. NPM/ALK binds and phosphorylates the RNA/DNA-binding protein PSF in anaplastic large-cell lymphoma.

    Science.gov (United States)

    Galietta, Annamaria; Gunby, Rosalind H; Redaelli, Sara; Stano, Paola; Carniti, Cristiana; Bachi, Angela; Tucker, Philip W; Tartari, Carmen J; Huang, Ching-Jung; Colombo, Emanuela; Pulford, Karen; Puttini, Miriam; Piazza, Rocco G; Ruchatz, Holger; Villa, Antonello; Donella-Deana, Arianna; Marin, Oriano; Perrotti, Danilo; Gambacorti-Passerini, Carlo

    2007-10-01

    The oncogenic fusion tyrosine kinase nucleophosmin/anaplastic lymphoma kinase (NPM/ALK) induces cellular transformation in anaplastic large-cell lymphomas (ALCLs) carrying the t(2;5) chromosomal translocation. Protein-protein interactions involving NPM/ALK are important for the activation of downstream signaling pathways. This study was aimed at identifying novel NPM/ALK-binding proteins that might contribute to its oncogenic transformation. Using a proteomic approach, several RNA/DNA-binding proteins were found to coimmunoprecipitate with NPM/ALK, including the multifunctional polypyrimidine tract binding proteinassociated splicing factor (PSF). The interaction between NPM/ALK and PSF was dependent on an active ALK kinase domain and PSF was found to be tyrosine-phosphorylated in NPM/ALK-expressing cell lines and in primary ALK(+) ALCL samples. Furthermore, PSF was shown to be a direct substrate of purified ALK kinase domain in vitro, and PSF Tyr293 was identified as the site of phosphorylation. Y293F PSF was not phosphorylated by NPM/ALK and was not delocalized in NPM/ALK(+) cells. The expression of ALK fusion proteins induced delocalization of PSF from the nucleus to the cytoplasm and forced overexpression of PSF-inhibited proliferation and induced apoptosis in cells expressing NPM/ALK. PSF phosphorylation also increased its binding to RNA and decreased the PSF-mediated suppression of GAGE6 expression. These results identify PSF as a novel NPM/ALK-binding protein and substrate, and suggest that PSF function may be perturbed in NPM/ALK-transformed cells.

  14. Cloning, expression and nuclear localization of human NPM3, a member of the nucleophosmin/nucleoplasmin family of nuclear chaperones

    Directory of Open Access Journals (Sweden)

    Ganguly Amit

    2001-11-01

    Full Text Available Abstract Background Studies suggest that the related proteins nucleoplasmin and nucleophosmin (also called B23, NO38 or numatrin are nuclear chaperones that mediate the assembly of nucleosomes and ribosomes, respectively, and that these activities are accomplished through the binding of basic proteins via their acidic domains. Recently discovered and less well characterized members of this family of acidic phosphoproteins include mouse nucleophosmin/nucleoplasmin 3 (Npm3 and Xenopus NO29. Here we report the cloning and initial characterization of the human ortholog of Npm3. Results Human genomic and cDNA clones of NPM3 were isolated and sequenced. NPM3 lies 5.5 kb upstream of FGF8 and thus maps to chromosome 10q24-26. In addition to amino acid similarities, NPM3 shares many physical characteristics with the nucleophosmin/nucleoplasmin family, including an acidic domain, multiple potential phosphorylation sites and a putative nuclear localization signal. Comparative analyses of 14 members of this family from various metazoans suggest that Xenopus NO29 is a candidate ortholog of human and mouse NPM3, and they further group both proteins closer with the nucleoplasmins than with the nucleophosmins. Northern blot analysis revealed that NPM3 was strongly expressed in all 16 human tissues examined, with especially robust expression in pancreas and testis; lung displayed the lowest level of expression. An analysis of subcellular fractions of NIH3T3 cells expressing epitope-tagged NPM3 revealed that NPM3 protein was localized solely in the nucleus. Conclusions Human NPM3 is an abundant and widely expressed protein with primarily nuclear localization. These biological activities, together with its physical relationship to the chaparones nucleoplasmin and nucleophosmin, are consistent with the proposed function of NPM3 as a molecular chaperone functioning in the nucleus.

  15. The cytoplasmic NPM mutant induces myeloproliferation in a transgenic mouse model.

    Science.gov (United States)

    Cheng, Ke; Sportoletti, Paolo; Ito, Keisuke; Clohessy, John G; Teruya-Feldstein, Julie; Kutok, Jeffery L; Pandolfi, Pier Paolo

    2010-04-22

    Although NPM1 gene mutations leading to aberrant cytoplasmic expression of nucleophosmin (NPMc(+)) are the most frequent genetic lesions in acute myeloid leukemia, there is yet no experimental model demonstrating their oncogenicity in vivo. We report the generation and characterization of a transgenic mouse model expressing the most frequent human NPMc(+) mutation driven by the myeloid-specific human MRP8 promoter (hMRP8-NPMc(+)). In parallel, we generated a similar wild-type NPM trans-genic model (hMRP8-NPM). Interestingly, hMRP8-NPMc(+) transgenic mice developed myeloproliferation in bone marrow and spleen, whereas nontransgenic littermates and hMRP8-NPM transgenic mice remained disease free. These findings provide the first in vivo evidence indicating that NPMc(+) confers a proliferative advantage in the myeloid lineage. No spontaneous acute myeloid leukemia was found in hMPR8-NPMc(+) or hMRP8-NPM mice. This model will also aid in the development of therapeutic regimens that specifically target NPMc(+).

  16. Public-enterprise and total quality management

    DEFF Research Database (Denmark)

    Madsen, Ole Nørgaard

    1995-01-01

    Offentlige virksomheder er i stigende grad (service-) producerende og brugerorienterede. I konsekvens heraf trænger management-tankegangen (eksempelsvis TQM) ind i offentlige virksomheder, selv om der stadig er barrierer herimod. Artiklen beskriver en model for kvalitet i offentlig virksomhed og ...

  17. IL-2R common gamma-chain is epigenetically silenced by nucleophosphin-anaplastic lymphoma kinase (NPM-ALK) and acts as a tumor suppressor by targeting NPM-ALK.

    Science.gov (United States)

    Zhang, Qian; Wang, Hong Yi; Liu, Xiaobin; Bhutani, Gauri; Kantekure, Kanchan; Wasik, Mariusz

    2011-07-19

    Anaplastic lymphoma kinase (ALK), physiologically expressed only by certain neural cells, becomes highly oncogenic, when aberrantly expressed in nonneural tissues as a fusion protein with nucleophosphin (NPM) and other partners. The reason why NPM-ALK succeeds in transforming specifically CD4(+) T lymphocytes remains unknown. The IL-2R common γ-chain (IL-2Rγ) is shared by receptors for several cytokines that play key roles in the maturation and growth of normal CD4(+) T lymphocytes and other immune cells. We show that IL-2Rγ expression is inhibited in T-cell lymphoma cells expressing NPM-ALK kinase as a result of DNA methylation of the IL-2Rγ gene promoter. IL-2Rγ promoter methylation is induced in malignant T cells by NPM-ALK. NPM-ALK acts through STAT3, a transcription factor that binds to the IL-2Rγ gene promoter and enhances binding of DNA methyltransferases (DNMTs) to the promoter. In addition, STAT3 suppresses expression of miR-21, which selectively inhibits DNMT1 mRNA expression. Reconstitution of IL-2Rγ expression leads to loss of the NPM-ALK protein and, consequently, apoptotic cell death of the lymphoma cells. These results demonstrate that the oncogenic tyrosine kinase NPM-ALK induces epigenetic silencing of the IL-2Rγ gene and that IL-2Rγ acts as a tumor suppressor by reciprocally inhibiting expression of NPM-ALK.

  18. Crisis Communication and Management: Surviving a Public Relations Crisis

    Science.gov (United States)

    Eramo, Eric M.

    2009-01-01

    Crisis management, or crisis communication, is never a good thing for a business to experience. It is, however, a public relations' professional moment to shine and put their honed skills to good use. A good crisis management plan is not only action during the crisis but preparation and reflection. Hiring a PR firm that deals with crisis…

  19. 75 FR 70722 - New England Fishery Management Council; Public Meeting

    Science.gov (United States)

    2010-11-18

    ... National Oceanic and Atmospheric Administration RIN: 0648-XA044 New England Fishery Management Council... Administration (NOAA), Commerce. ACTION: Notice of a public meeting. SUMMARY: The New England Fishery Management... at 9:30 a.m. ADDRESSES: The meeting will be held at the Sheraton Harborside Hotel, 250 Market Street...

  20. 75 FR 78680 - New England Fishery Management Council; Public Meeting

    Science.gov (United States)

    2010-12-16

    ... National Oceanic and Atmospheric Administration RIN 0648-XA090 New England Fishery Management Council... Administration (NOAA), Commerce. ACTION: Notice; public meeting. SUMMARY: The New England Fishery Management... held at the Radisson Airport Hotel, 2081 Post Road, Warwick, RI 02886: telephone: (401) 739-3000; fax...

  1. 76 FR 77492 - New England Fishery Management Council; Public Meeting

    Science.gov (United States)

    2011-12-13

    ... National Oceanic and Atmospheric Administration RIN 0648-XA864 New England Fishery Management Council... Administration (NOAA), Commerce. ACTION: Notice; public meeting. SUMMARY: The New England Fishery Management... will be held at the Hotel Providence, 139 Mathewson Street, Providence, RI 02903: telephone: (401) 861...

  2. 77 FR 29595 - New England Fishery Management Council; Public Meeting

    Science.gov (United States)

    2012-05-18

    ... Management Council; Public Meeting AGENCY: National Marine Fisheries Service (NMFS), National Oceanic and... Management Council's (Council) Herring Oversight Committee will meet to consider actions affecting New... 6, 2012 at 8:30 a.m. ADDRESSES: The meeting will be held at the Radisson Hotel Plymouth Harbor, 180...

  3. 75 FR 80796 - New England Fishery Management Council; Public Meeting

    Science.gov (United States)

    2010-12-23

    ... National Oceanic and Atmospheric Administration RIN 0648-XA107 New England Fishery Management Council... Administration (NOAA), Commerce. ACTION: Notice; public meeting. SUMMARY: The New England Fishery Management.... ADDRESSES: The meeting will be held at the Clarion Hotel, 1230 Congress Street, Portland, ME 04102...

  4. 75 FR 63147 - New England Fishery Management Council; Public Meeting

    Science.gov (United States)

    2010-10-14

    ... National Oceanic and Atmospheric Administration RIN 0648-XZ63 New England Fishery Management Council... Administration (NOAA), Commerce. ACTION: Notice of a public meeting. SUMMARY: The New England Fishery Management... held at the Providence Biltmore Hotel, 11 Dorrance Street, Providence, RI 02903; telephone: (401) 421...

  5. 78 FR 25256 - New England Fishery Management Council; Public Meeting

    Science.gov (United States)

    2013-04-30

    ... National Oceanic and Atmospheric Administration RIN 0648-XC648 New England Fishery Management Council... Administration (NOAA), Commerce. ACTION: Notice; public meeting. SUMMARY: The New England Fishery Management...: Meeting address: The meeting will be held at the Sheraton Harborside Hotel, 250 Market Street, Portsmouth...

  6. 75 FR 80798 - New England Fishery Management Council; Public Meeting

    Science.gov (United States)

    2010-12-23

    ... National Oceanic and Atmospheric Administration RIN 0648-XA106 New England Fishery Management Council... Administration (NOAA), Commerce. ACTION: Notice; public meeting. SUMMARY: The New England Fishery Management... a.m. ADDRESSES: The meeting will be held at the Clarion Hotel, 1230 Congress Street, Portland, ME...

  7. 76 FR 2083 - Pacific Fishery Management Council; Public Meeting

    Science.gov (United States)

    2011-01-12

    ... National Oceanic and Atmospheric Administration RIN 0648-XA137 Pacific Fishery Management Council; Public.... ADDRESSES: The Joint Canada-U.S. Review Panel for Pacific hake/whiting will be held at the Hotel Deca, 4507... Management Council (Pacific Council), 7700 NE Ambassador Place, Suite 101, Portland, OR 97220-1384. FOR...

  8. 78 FR 30869 - New England Fishery Management Council; Public Meeting

    Science.gov (United States)

    2013-05-23

    ... National Oceanic and Atmospheric Administration RIN 0648-XC693 New England Fishery Management Council... Administration (NOAA), Commerce. ACTION: Notice; public meeting. SUMMARY: The New England Fishery Management... 10 a.m. ADDRESSES: Meeting address: The meeting will be held at the Providence Biltmore Hotel, 11...

  9. 75 FR 78681 - New England Fishery Management Council; Public Meeting

    Science.gov (United States)

    2010-12-16

    ... National Oceanic and Atmospheric Administration RIN 0648-XA089 New England Fishery Management Council... Administration (NOAA), Commerce. ACTION: Notice; public meeting. SUMMARY: The New England Fishery Management... held at the Clarion Hotel, 1230 Congress Street, Portland, ME 04102; telephone: (207) 774-5611; fax...

  10. 77 FR 14351 - New England Fishery Management Council; Public Meeting

    Science.gov (United States)

    2012-03-09

    ... National Oceanic and Atmospheric Administration RIN 0648-XB073 New England Fishery Management Council... Administration (NOAA), Commerce. ACTION: Notice; public meeting. SUMMARY: The New England Fishery Management... will be held at the Providence Biltmore Hotel, 11 Dorrance Street, Providence, RI 02903; telephone...

  11. 78 FR 70282 - New England Fishery Management Council; Public Meetings

    Science.gov (United States)

    2013-11-25

    ... National Oceanic and Atmospheric Administration RIN 0648-XC993 New England Fishery Management Council... Administration (NOAA), Commerce. ACTION: Notice; public meetings. SUMMARY: The New England Fishery Management... SUPPLEMENTARY INFORMATION. ADDRESSES: Meeting address: These meetings will be held at the Omni Providence Hotel...

  12. 77 FR 58982 - New England Fishery Management Council; Public Meeting

    Science.gov (United States)

    2012-09-25

    ... National Oceanic and Atmospheric Administration RIN 0648-XC256 New England Fishery Management Council... Administration (NOAA), Commerce. ACTION: Notice; public meeting. SUMMARY: The New England Fishery Management... a.m. ADDRESSES: The meeting will be held at the Ashworth by the Sea Hotel, 295 Ocean Boulevard...

  13. 75 FR 54092 - North Pacific Fishery Management Council; Public Meeting

    Science.gov (United States)

    2010-09-03

    ...-XY69 North Pacific Fishery Management Council; Public Meeting AGENCY: National Marine Fisheries Service... meeting. SUMMARY: The North Pacific Fishery Management Council's (Council) Scallop Plan Team will meet September 28th, 2010 at the Anchorage Hilton Hotel. DATES: The meeting will be held on September 28, 2010...

  14. 76 FR 77214 - New England Fishery Management Council; Public Meeting

    Science.gov (United States)

    2011-12-12

    ... National Oceanic and Atmospheric Administration RIN 0648-XA862 New England Fishery Management Council... Administration (NOAA), Commerce. ACTION: Notice; public meeting. SUMMARY: The New England Fishery Management... held at the Hotel Providence, 139 Mathewson Street, Providence, RI 02903; telephone: (401) 861-8000...

  15. Politics and the Public Library: A Management Guide.

    Science.gov (United States)

    Mason, Marilyn Gell

    1989-01-01

    Discusses the challenges of running a library in a political environment, and offers observations and strategies to aid in public library management. Areas discussed include governance, funding, personnel management, relationships with the press, working with elected officials, and negotiating strategies and skills. (CLB)

  16. ECO-Report - Research-management-public partnership continues

    Science.gov (United States)

    Jane Kapler Smith; Greg Jones; Nan Christianson; Lucia Solorzano; Gloria Weisgerber; Steve Arno; Sallie J. Hejl; F. Jeremy Wheeler; Timothy S. Redman; Joshua J. Tewksbury; Tom DeLuca; K. Zouhar

    1998-01-01

    ECO-Report is an annual Rocky Mountain Research Station (RMRS) publication which contains a set of articles showcasing the Bitterroot Ecosystem Management Research Project (BEMRP) research projects and activities. The articles are concise, user-friendly, and designed to inform a broad range of audiences interested in ecosystem management. Articles featured in...

  17. 77 FR 19228 - New England Fishery Management Council; Public Meeting

    Science.gov (United States)

    2012-03-30

    ... Administration (NOAA), Commerce. ACTION: Notice; public meeting. SUMMARY: The New England Fishery Management... National Oceanic and Atmospheric Administration RIN 0648-XB137 New England Fishery Management Council... 04101; telephone: (207) 775-2311; fax: (207) 772-4017. Council address: New England Fishery...

  18. 76 FR 57718 - New England Fishery Management Council; Public Meeting

    Science.gov (United States)

    2011-09-16

    ... Administration (NOAA), Commerce. ACTION: Notice; public meeting. SUMMARY: The New England Fishery Management... National Oceanic and Atmospheric Administration RIN 0648-XA706 New England Fishery Management Council... 01960; telephone: (978) 535-5000; fax: (978) 535-9610. Council address: New England Fishery...

  19. Effectiveness of infrastructure asset management: challenges for public agencies

    NARCIS (Netherlands)

    Schraven, Daan; Hartmann, Andreas; Dewulf, Geert P.M.R.

    2011-01-01

    Purpose: The aim of this research is to better understand the decisions in infrastructure asset management at public agencies and the challenges of these agencies to improve the effectiveness of their decision making. Design/methodology/approach: Based on a literature review on asset management at

  20. Agency relations and managed performance in public universities in Uganda

    Directory of Open Access Journals (Sweden)

    James R.K. Kagaari

    2013-01-01

    Full Text Available Orientation: This article focused on the need for improved employer-employee relationships in order for public universities in Uganda to achieve their intended objectives.Research purpose: The purpose of this article was to review the need for appropriate employer-employee relationships that will ensure quality services and service delivery in public universities in Uganda.Motivation for the study: The researchers set out to examine why managers of public universities in Uganda were continuously paying less attention to the needs of the employees.Research design, approach and method: A descriptive research design was employed and 12 respondents, purposively selected from 4 public universities, were interviewed. Data were recorded, transcribed and analysed using Nvivo software. This article is based on the perspective of agency theory, and discussed the contractual relationship between management and employees. The agency theory was deemed necessary because of its contribution to organisational literature.Main findings: There is a need to create and nurture a collegial working climate that promotes quality interactions through information sharing. This results in creating and retaining motivated and committed employees, and also helps to overcome the paradox of balancing the high demand for university education whilst offering quality services.Practical/managerial implications: Managers have to continuously monitor and accommodate employee needs and demands.Contribution/value-add: The potential value of the paper is its function as a guide for public universities to have visionary managers that will introduce new approaches to managing public universities in a competitive global environment.

  1. PUBLIC RELATIONS PROFESSIONALS’ PERCEPTION OF CONFLICT MANAGEMENT AS A MANAGEMENT FUNCTION

    Directory of Open Access Journals (Sweden)

    Tugce Ertem Eray

    2016-12-01

    Full Text Available Conflicts are a part of daily life that people encounter at home, work, and in organizations. It is evident that organizational conflicts are becoming more complex. In this respect, it is important for senior executives not to disregard these conflicts and involve public relations professionals in the conflict management processes. Hence, it is expected that public relations professionals become participants in the strategic planning process and that senior management relies on their experience and talents during the strategic planning process of organizations and resolution of issues. Another definition of public relations has emerged over the past years, even though the recent definitions of public relations focus on developing mutually beneficial relationships between organizations and their publics. Glen T. Cameron from University of Missouri defines public relations as management of conflict and competition strategically for the benefit of one’s own organization and, if possible, mutual benefit of organizations and individuals. It is impossible to disregard the influence of public relations professionals on managing the conflicts between an organization and its peers, and hence it is important to conduct further research on their approach to conflict management. With this motive, research questions have been generated based on the data presented by Professor Kenneth Plowman as a result of his analysis of strategic management of public relations in conflict management. Using the semi-structured interview technique, public relations professionals in Turkey were asked to describe their approach to conflict management.

  2. Planning analysis and political steering with New Public Management

    DEFF Research Database (Denmark)

    Sager, Tore Øivin; Sørensen, Claus Hedegaard

    2011-01-01

    of interviews sheds light on the apparent paradox that parliamentarians accept delegation of highway investment decisions despite their profound scepticism to the cost-benefit analyses and impact calculations that are essential to management by objectives and results, which was to give them continued political...... by the Government. The political concentration on strategic steering, the concomitant delegation, and management by objectives and results are central components of New Public Management....

  3. European developments in public sector human resource management

    OpenAIRE

    Hegewisch, A.; Larsen, Henrik Holt

    1994-01-01

    This paper discusses national differences in HRM within the public sector in nine European countties. Drawing on data from the PW Cranfeld Survey of International Human Resource Management we examine the decentralisation of HR policy decisions and trends in the devolvement to line management of responsibility for human resource management. In particular we looked at trends in the compensation area, ie pay determination and merit/ performance related pay and its impact on perfor...

  4. Planning analysis and political steering with New Public Management

    DEFF Research Database (Denmark)

    Sager, Tore Øivin; Sørensen, Claus Hedegaard

    2011-01-01

    of interviews sheds light on the apparent paradox that parliamentarians accept delegation of highway investment decisions despite their profound scepticism to the cost-benefit analyses and impact calculations that are essential to management by objectives and results, which was to give them continued political...... by the Government. The political concentration on strategic steering, the concomitant delegation, and management by objectives and results are central components of New Public Management....

  5. The External Networking Behaviour of Public Managers

    DEFF Research Database (Denmark)

    Hansen, Morten Balle; Villadsen, Anders Ryom

    2017-01-01

    There has been an increasing focus on managerial external networking behaviour within public administration. While most previous quantitative research has analysed such behaviour one-dimensionally, we suggest a two-dimensional conceptualization based on the concepts of weak and strong ties....... Utilizing measures resembling previous research, we explore the utility of the approach in an exploratory study of Danish local government. Our findings suggest that the two dimensions of external networking behaviour are distinct. We discuss our approach compared to previous approaches and argue...

  6. Normal pressure hydrocephalus: did publications alter management?

    Science.gov (United States)

    Vanneste, J; van Acker, R

    1990-07-01

    Forty six Dutch neurologists and neurosurgeons were interviewed to evaluate the clinical value of research articles on normal pressure hydrocephalus (NPH). From this survey it appears that most clinicians still limit investigations to psychometry, CSF-tap test(s), and cisternography. The main reasons for not using other techniques were: their invasiveness, technical complexity, poor availability, lack of time and doubt on their additional predictive value. There is an obvious discrepancy between the quantity of publications on NPH and their impact and their ability to assist clinicians in selecting potential NPH patients for a shunt.

  7. A "liaison dangereuse" between AUF1/hnRNPD and the oncogenic tyrosine kinase NPM-ALK.

    Science.gov (United States)

    Fawal, Mohamad; Armstrong, Florence; Ollier, Severine; Dupont, Henri; Touriol, Christian; Monsarrat, Bernard; Delsol, Georges; Payrastre, Bernard; Morello, Dominique

    2006-10-15

    Nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) is a chimeric protein expressed in a subset of cases of anaplastic large cell lymphoma (ALCL) for which constitutive expression represents a key oncogenic event. The ALK signaling pathway is complex and probably involves functional redundancy between various signaling substrates of ALK. Despite numerous studies on signaling mediators, the molecular mechanisms contributing to the distinct oncogenic features of NPM-ALK remain incompletely understood. The search for additional interacting partners of NPM-ALK led to the discovery of AUF1/hnRNPD, a protein implicated in AU-rich element (ARE)-directed mRNA decay. AUF1 was immunoprecipitated with ALK both in ALCL-derived cells and in NIH3T3 cells stably expressing NPM-ALK or other X-ALK fusion proteins. AUF1 and NPM-ALK were found concentrated in the same cytoplasmic foci, whose formation required NPM-ALK tyrosine kinase activity. AUF1 was phosphorylated by ALK in vitro and was hyperphosphorylated in NPM-ALK-expressing cells. Its hyperphosphorylation was correlated with increased stability of several AUF1 target mRNAs encoding key regulators of cell proliferation and with increased cell survival after transcriptional arrest. Thus, AUF1 could function in a novel pathway mediating the oncogenic effects of NPM-ALK. Our data establish an important link between oncogenic kinases and mRNA turnover, which could constitute a critical aspect of tumorigenesis.

  8. Favorable prognostic impact of NPM1 gene mutations in childhood acute myeloid leukemia, with emphasis on cytogenetically normal AML.

    NARCIS (Netherlands)

    Hollink, I.H.; Zwaan, C.M.; Zimmermann, M.; Arentsen-Peters, T.C.; Pieters, R.; Cloos, J.; Kaspers, G.J.L.; Graaf, S.S.N. de; Harbott, J.; Creutzig, U.; Reinhardt, D.; Heuvel-Eibrink, M.M. van den; Thiede, C.

    2009-01-01

    Nucleophosmin (NPM1) mutations occur frequently in adult cytogenetically normal acute myeloid leukemia (CN-AML) and confer favorable outcome. We investigated the frequency and prognostic significance of NPM1 mutations in childhood AML (n=298), specifically focusing on the CN-AML subgroup (n=100). Mu

  9. Public health emergencies and the public health/managed care challenge.

    Science.gov (United States)

    Rosenbaum, Sara; Skivington, Skip; Praeger, Sandra

    2002-01-01

    The relationship between insurance and public health is an enduring topic in public health policy and practice. Insurers share certain attributes with public health. But public health agencies operate in relation to the entire community that they are empowered by public law to serve and without regard to the insurance status of community residents; on the other hand, insurers (whether managed care or otherwise) are risk-bearing entities whose obligations are contractually defined and limited to enrolled members and sponsors. Public insurers such as Medicare and Medicaid operate under similar constraints. The fundamental characteristics that distinguish managed care-style insurance and public health become particularly evident during periods of public health emergency, when a public health agency's basic obligations to act with speed and flexibility may come face to face with the constraints on available financing that are inherent in the structure of insurance. Because more than 70% of all personal health care in the United States is financed through insurance, public health agencies effectively depend on insurers to finance necessary care and provide essential patient-level data to the public health system. Critical issues of state and federal policy arise in the context of the public health/insurance relations during public health emergencies. These issues focus on coverage and the power to make coverage decisions, as well as the power to define service networks and classify certain data as exempt from public reporting. The extent to which a formal regulatory approach may become necessary is significantly affected by the extent to which private entities themselves respond to the problem with active efforts to redesign their services and operations to include capabilities and accountability in the realm of public health emergency response.

  10. Oncogenic tyrosine kinase NPM-ALK induces expression of the growth-promoting receptor ICOS

    DEFF Research Database (Denmark)

    Zhang, Qian; Wang, HongYi; Kantekure, Kanchan

    2011-01-01

    Here we report that T-cell lymphoma cells carrying the NPM-ALK fusion protein (ALK(+) TCL) frequently express the cell-stimulatory receptor ICOS. ICOS expression in ALK(+) TCL is moderate and strictly dependent on the expression and enzymatic activity of NPM-ALK. NPM-ALK induces ICOS expression via...... STAT3, which triggers the transcriptional activity of the ICOS gene promoter. In addition, STAT3 suppresses the expression of miR-219 that, in turn, selectively inhibits ICOS expression. ALK(+) TCL cell lines display extensive DNA methylation of the CpG island located within intron 1, the putative...... enhancer region, of the ICOS gene, whereas cutaneous T-cell lymphoma cell lines, which strongly express ICOS, show no methylation of the island. Treatment of the ALK(+) TCL cell lines with DNA methyltransferase inhibitor reversed the CpG island methylation and augmented the expression of ICOS m...

  11. Public debate - radioactive wastes management; Debat public - gestion des dechets radioactifs

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2005-07-01

    Between September 2005 and January 2006 a national debate has been organized on the radioactive wastes management. This debate aimed to inform the public and to allow him to give his opinion. This document presents, the reasons of this debate, the operating, the synthesis of the results and technical documents to bring information in the domain of radioactive wastes management. (A.L.B.)

  12. Fusion tyrosine kinase NPM-ALK Deregulates MSH2 and suppresses DNA mismatch repair function novel insights into a potent oncoprotein.

    Science.gov (United States)

    Young, Leah C; Bone, Kathleen M; Wang, Peng; Wu, Fang; Adam, Benjamin A; Hegazy, Samar; Gelebart, Pascal; Holovati, Jelena; Li, Liang; Andrew, Susan E; Lai, Raymond

    2011-07-01

    The fusion tyrosine kinase NPM-ALK is central to the pathogenesis of ALK-positive anaplastic large cell lymphoma (ALK(+)ALCL). We recently identified that MSH2, a key DNA mismatch repair (MMR) protein integral to the suppression of tumorigenesis, is an NPM-ALK-interacting protein. In this study, we found in vitro evidence that enforced expression of NPM-ALK in HEK293 cells suppressed MMR function. Correlating with these findings, six of nine ALK(+)ALCL tumors displayed evidence of microsatellite instability, as opposed to none of the eight normal DNA control samples (P = 0.007, Student's t-test). Using co-immunoprecipitation, we found that increasing levels of NPM-ALK expression in HEK293 cells resulted in decreased levels of MSH6 bound to MSH2, whereas MSH2·NPM-ALK binding was increased. The NPM-ALK·MSH2 interaction was dependent on the activation/autophosphorylation of NPM-ALK, and the Y191 residue of NPM-ALK was a crucial site for this interaction and NPM-ALK-mediated MMR suppression. MSH2 was found to be tyrosine phosphorylated in the presence of NPM-ALK. Finally, NPM-ALK impeded the expected DNA damage-induced translocation of MSH2 out of the cytoplasm. To conclude, our data support a model in which the suppression of MMR by NPM-ALK is attributed to its ability to interfere with normal MSH2 biochemistry and function.

  13. Public Expenditures, Budgetary Sustainability and the Assessment of Management of Public Expenditures in Kosovo

    Directory of Open Access Journals (Sweden)

    Behxhet Brajshori

    2009-05-01

    Full Text Available Public expenditures are public outlays which competent state organs realize for the purpose of fulfilling obligations of general public interest. They are manifested in different forms and in different social, economic and political areas. Public expenditures produce direct and indirect effects in production and influence consumption and prices. Economic structure and conjectural courses of one country have an impact on the highness of the public expenditures. Economic and social subsidies present the main instruments for achieving economic and social effects through the policy of public expenditures, whilst in conjectural economies; the effect of public expenditures is large and is realized through the mechanism of multiplicators which are used when the economy is in the state of economic stagnation and recession. After the war, Kosovo built a new fiscal system according to the best international practices. The tax system consists of some taxes, it has a wide spread of tax charges and applies relatively low tax rates. Both budgetary revenues and budgetary consumption have marked certain variations in relation to GDP. Currently, The Kosovo Consolidated Budget (KCB is completely fulfilled by domestic revenues. It is considered that, even if the budgetary consumption increases up to 30-34% of GDP, this raise will not endanger budgetary sustainability of the country. According to the World Bank assessment (PEFA document- 2006 on the Effectiveness of Management of Public Expenditures in Kosovo, based on the performance of main indicators of management of public finances, the effectiveness of management of public expenditures in Kosovo is relatively satisfactory. According to the draft-document of the World Bank and the Government of Kosovo (PEFA-2008, the quality of management of public expenditures in 2008 has been profoundly improved.

  14. Sustainable waste management in the UK: the public health role.

    Science.gov (United States)

    Mohan, R; Spiby, J; Leonardi, G S; Robins, A; Jefferis, S

    2006-10-01

    This paper discusses waste management in the UK and its relationship with health. It aims to outline the role of health professionals in the promotion of waste management, and argues for a change in their role in waste management regulation to help make the process more sustainable. The most common definition of sustainable development is that by the Brundtland commission, i.e. "development that meets the needs of the present without compromising the ability of future generations to meet their own needs". Managing waste sites in a manner that minimises toxic impacts on the current and future generations is obviously a crucial part of this. Although the management of waste facilities is extremely complex, the Integrated Pollution Prevention and Control regime, which requires the input of public health professionals on the regulation of such sites, means that all waste management installations should now be operating in a fashion that minimises any toxicological risks to human health. However, the impacts upon climate change, resource use and health inequalities, as well as the effects of waste transportation, are currently not considered to be part of public health professionals' responsibilities when dealing with these sites. There is also no requirement for public health professionals to become involved in waste management planning issues. The fact that public health professionals are not involved in any of these issues makes it unlikely that the potential impacts upon health are being considered fully, and even more unlikely that waste management will become more sustainable. This paper aims to show that by only considering direct toxicological impacts, public health professionals are not fully addressing all the health issues and are not contributing towards sustainability. There is a need for a change in the way that health professionals deal with waste management issues.

  15. Public protection – reliable allergen risk management

    Science.gov (United States)

    Janković, V.; Popov Raljić, J.; Đorđević, V.

    2017-09-01

    Consumers with potentially fatal food allergies are dependent on correct product labelling to protect their health. The food industry is responsible for providing every detail consumers need to make informed decisions. Considering public health, food suppliers have to monitor the presence of allergens, prevent cross-contamination and label products accurately. Allergen labelling of food products, drinks and non pre-packed food and drink products is clearly defined with legal regulations. To achieve this, a complete understanding of each product’s allergenic ingredients is needed and cross-contamination of food with allergens must be avoided. Raw materials need to be checked, every ingredient must be verified and every single allergen has to be stipulated. A mislabeled product could be recalled at potential cost, financially damaging business and at the same time, negatively impacting brand and reputation.

  16. Public health laboratory quality management in a developing country.

    Science.gov (United States)

    Wangkahat, Khwanjai; Nookhai, Somboon; Pobkeeree, Vallerut

    2012-01-01

    The article aims to give an overview of the system of public health laboratory quality management in Thailand and to produce a strengths, weaknesses, opportunities and threats (SWOT) analysis that is relevant to public health laboratories in the country. The systems for managing laboratory quality that are currently employed were described in the first component. The second component was a SWOT analysis, which used the opinions of laboratory professionals to identify any areas that could be improved to meet quality management systems. Various quality management systems were identified and the number of laboratories that met both international and national quality management requirements was different. The SWOT analysis found the opportunities and strengths factors offered the best chance to improve laboratory quality management in the country. The results are based on observations and brainstorming with medical laboratory professionals who can assist laboratories in accomplishing quality management. The factors derived from the analysis can help improve laboratory quality management in the country. This paper provides viewpoints and evidence-based approaches for the development of best possible practice of services in public health laboratories.

  17. NPM-ALK signals through glycogen synthase kinase 3β to promote oncogenesis.

    Science.gov (United States)

    McDonnell, S R P; Hwang, S R; Basrur, V; Conlon, K P; Fermin, D; Wey, E; Murga-Zamalloa, C; Zeng, Z; Zu, Y; Elenitoba-Johnson, K S J; Lim, M S

    2012-08-01

    Anaplastic large cell lymphoma (ALCL) is the most common type of pediatric peripheral T-cell lymphoma. In 70-80% of cases, the chromosomal aberration t(2;5)(p23;q35) results in the juxtaposition of anaplastic lymphoma kinase (ALK) with nucleophosmin (NPM) and the subsequent expression of the NPM-ALK fusion protein. NPM-ALK is a chimeric tyrosine kinase, which induces numerous signaling pathways that drive proliferation and abrogate apoptosis. However, the mechanisms that lead to activation of downstream growth regulatory molecules have not been completely elucidated. Using a mass spectrometry-based phosphoproteomic screen, we identified GSK3β as a signaling mediator of NPM-ALK. Using a selective inhibitor of ALK, we demonstrated that the tyrosine kinase activity of ALK regulates the serine-9 phosphorylation of GSK3β. Expression of NPM-ALK in 293T cells led to an increase of pS(9)-GSK3β (glycogen synthase kinase 3 beta) compared with kinase-defective K210R mutant NPM-ALK, but did not affect total GSK3β levels. Phosphorylation of pS(9)-GSK3β by NPM-ALK was mediated by the PI3K/AKT signaling pathway. ALK inhibition resulted in degradation of GSK3β substrates Mcl-1 and CDC25A, which was recovered upon chemical inhibition of the proteasome (MG132). Furthermore, the degradation of Mcl-1 was recoverable with inhibition of GSK3β. ALK inhibition also resulted in decreased cell viability, which was rescued by GSK3β inhibition. Furthermore, stable knockdown of GSK3β conferred resistance to the growth inhibitory effects of ALK inhibition using viability and colony formation assays. pS(9)-GSK3β and CDC25A were selectively expressed in neoplastic cells of ALK+ALCL tissue biopsies, and showed a significant correlation (PNPM-ALK regulates the phosphorylation of S(9)-GSK3β by PI3K/AKT. The subsequent inhibition of GSK3β activity results in accumulation of CDC25A and Mcl-1, which confers the advantage of growth and protection from apoptosis. These findings provide

  18. Investigations and calculations into decreasing the uncertainty of a nanopositioning and nanomeasuring machine (NPM-Machine)

    Science.gov (United States)

    Schmidt, I.; Hausotte, T.; Gerhardt, U.; Manske, E.; Jäger, G.

    2007-02-01

    Continuously increasing demands on nanopositioning and nanomeasuring (NPM) machines require a detailed analysis of and a decrease in measurement uncertainty. Initial studies have been done in the field of length and angle measurement. The analysis resulted in updated assemblies, which were investigated further. Significant improvements in mechanical stability, drift behaviour and temperature dependence were produced. To minimize the undesired heat production by the non-self-locking vertical linear drive systems, an improved weight force compensation arrangement adaptable to different object masses was developed and tested. Also, the system's natural frequencies were analysed. A modified structure with increased stiffness of the vertical drive system was designed to improve the NPM's dynamic behaviour.

  19. The tyrosine phosphatase Shp2 interacts with NPM-ALK and regulates anaplastic lymphoma cell growth and migration.

    Science.gov (United States)

    Voena, Claudia; Conte, Chiara; Ambrogio, Chiara; Boeri Erba, Elisabetta; Boccalatte, Francesco; Mohammed, Shabaz; Jensen, Ole N; Palestro, Giorgio; Inghirami, Giorgio; Chiarle, Roberto

    2007-05-01

    Anaplastic large cell lymphomas (ALCL) are mainly characterized by the reciprocal translocation t(2;5)(p23;q35) that involves the anaplastic lymphoma kinase (ALK) gene and generates the fusion protein NPM-ALK with intrinsic tyrosine kinase activity. NPM-ALK triggers several signaling cascades, leading to increased cell growth, resistance to apoptosis, and changes in morphology and migration of transformed cells. To search for new NPM-ALK interacting molecules, we developed a mass spectrometry-based proteomic approach in HEK293 cells expressing an inducible NPM-ALK and identified the tyrosine phosphatase Shp2 as a candidate substrate. We found that NPM-ALK was able to bind Shp2 in coprecipitation experiments and to induce its phosphorylation in the tyrosine residues Y542 and Y580 both in HEK293 cells and ALCL cell lines. In primary lymphomas, antibodies against the phosphorylated tyrosine Y542 of Shp2 mainly stained ALK-positive cells. In ALCL cell lines, Shp2-constitutive phosphorylation was dependent on NPM-ALK, as it significantly decreased after short hairpin RNA (shRNA)-mediated NPM-ALK knock down. In addition, only the constitutively active NPM-ALK, but not the kinase dead NPM-ALK(K210R), formed a complex with Shp2, Gab2, and growth factor receptor binding protein 2 (Grb2), where Grb2 bound to the phosphorylated Shp2 through its SH2 domain. Shp2 knock down by specific shRNA decreased the phosphorylation of extracellular signal-regulated kinase 1/2 and of the tyrosine residue Y416 in the activation loop of Src, resulting in impaired ALCL cell proliferation and growth disadvantage. Finally, migration of ALCL cells was reduced by Shp2 shRNA. These findings show a direct involvement of Shp2 in NPM-ALK lymphomagenesis, highlighting its critical role in lymphoma cell proliferation and migration.

  20. Identification of multiple SNT-binding sites on NPM-ALK oncoprotein and their involvement in cell transformation.

    Science.gov (United States)

    Chikamori, M; Fujimoto, J; Tokai-Nishizumi, N; Yamamoto, T

    2007-05-01

    The t(2;5) chromosomal translocation occurs in anaplastic large-cell lymphoma arising from activated T lymphocytes. This genomic rearrangement generates the nucleophosmin (NPM)-anaplastic lymphoma kinase (ALK) oncoprotein that is a chimeric protein consisting of parts of the nuclear protein NPM and ALK receptor protein-tyrosine kinase. We used yeast two-hybrid screening to identify an adaptor protein Suc1-associated neurotrophic factor-induced tyrosine-phosphorylated target (SNT)-2 as a new partner that interacted with the cytoplasmic domain of ALK. Immunoprecipitation assay revealed that SNT-1 and SNT-2 interacted with NPM-ALK and kinase-negative NPM-ALK mutant. Y156, Y567 and a 19-amino-acid sequence (aa 631-649) of NPM-ALK were essential for this interaction. The interaction through Y156 and Y567 was dependent on phosphorylation of these tyrosines, whereas the interaction through the 19-amino-acid sequence was independent of phosphorylation. NPM-ALK mutant protein mutated at these three binding sites showed significantly reduced transforming activity. This transformation-defective NPM-ALK mutant still interacted with signal transducing proteins such as phospholipase C-gamma and phosphatidylinositol 3-kinase, which were previously reported to be relevant to NPM-ALK-dependent tumorigenesis. These observations indicate that the three SNT-binding sites of NPM-ALK are important for its transforming activity. This raises a possibility that SNT family proteins play significant roles in cellular transformation triggered by NPM-ALK, which though remains to be verified.

  1. Mutation of NPM1 and FLT3 Genes in Acute Myeloid Leukemia and Their Association with Clinical and Immunophenotypic Features

    Directory of Open Access Journals (Sweden)

    Pradeep Singh Chauhan

    2013-01-01

    Full Text Available Background. Mutations in NPM1 and FLT3 genes represent the most frequent genetic alterations and important diagnostic and prognostic indicators in patients with acute myeloid leukemia (AML. Objective. We investigated the prevalence and clinical characteristics of NPM1 and FLT3 mutations in 161 patients of de novo AML including adults and children. Results. NPM1 mutation was found in 21% and FLT3 mutation in 25% of the AML patients. Thirteen (8% samples were positive for both NPM1 and FLT3/ITD mutations. Adult patients had significantly higher frequency of NPM1 mutation than children (25.8% versus 8.8%; P=0.02. Further, NPM1 mutation was found to be more frequent in patients above 45 years of age (P=0.02. NPM1 mutation was significantly associated with higher platelet count (P=0.05 and absence of hepatosplenomegaly (P=0.01, while FLT3/ITD mutation was associated with higher white blood count (P=0.01. Immunophenotypically, NPM1 mutation was associated with the lack of CD34 (P<0.001 and HLD-DR expression (P<0.001, while FLT3/ITD mutation was positively associated with the expression of CD7 (P=0.04. No correlation was found between NPM1 mutation and fusion gene. Interestingly, FLT3/ITD mutation was found to be inversely associated with AML/ETO fusion gene (P=0.04. Conclusions. The results suggest that distinct clinical and immunophenotypic characteristics of NPM1 and FLT3/ITD mutations present further insight into the molecular mechanism of leukemogenesis.

  2. How to integrate street-level bureaucracies into public management?

    DEFF Research Database (Denmark)

    Aagaard, Peter; Pedersen, John Storm

    the professionals in the public sector at the street-level such as social-workers, teachers, doctors, and other professionals have maintained autonomy regarding the provision, production and delivery of the specific core welfare services to the citizens as end users. By definition hard budget constraint...... and professionals´ autonomy do not fit well. To explore both theoretically and empirically the conflicts between hard budget constraint and professionals´ autonomy, the professionals´ provision, production and delivery of the services to the citizens with disability and socially disadvantaged people and the public...... management of the public spending on the services in Denmark is used as a case. Surprisingly, we find that the managers have been able to resolve the conflicts between the hard budget constraint and the professionals´ autonomy to a rather high degree. The managers have integrated the street...

  3. Development of Public Management: Theory, Experience and Prospects

    Directory of Open Access Journals (Sweden)

    Maksimchuk Olga Viktorovna

    2014-09-01

    Full Text Available The development can be seen as change any properties of the phenomenon over time. Preservation and modification of these properties are necessary for any development, but it must be observed them the necessary balance. Defining this balance in the system of public management as the basis of sustainability of socio-economic systems of different order - the problem is not completely solved by economics. The authors aim to justify the development of methodological approaches to public management, taking into account the specific socio-economic systems of various sizes; offer practical solutions and outline prospects along the way. Methodological basis of research was interdisciplinary and systemic approaches. Scientific results have theoretical and practical and can be applied in the process of scientific substantiation of decisions of public management in a variety of missions.

  4. Conceptualizing ORGANIZATIONAL HEALTH - Public health management and leadership perspectives

    DEFF Research Database (Denmark)

    Orvik, Arne

    The thesis introduces a new conceptual model of organizational health and discusses its implications for public health management and leadership. It is developed with reference to organizational theories and ideologies, including New Public Management, the use of which has coincided with increasing...... workplace health problems in health care organizations. The model is based on empirical research and theories in the fields of public health, health care organization and management, and institutional theory. It includes five dimensions and defines organizational health in terms of how an organization...... is able to cope with the tensions associated with diverse values and competing institutional logics. This definition calls for an understanding of the tensions between values associated with quality, efficiency and integrity, and a dialectical perspective when attempting to assess the integration as well...

  5. SWOT ANALYSIS-MANAGEMENT TECHNIQUES TO STREAMLINE PUBLIC BUSINESS MANAGEMENT

    OpenAIRE

    Rodica IVORSCHI

    2012-01-01

    SWOT analysis is the most important management techniques for understanding the strategic position of an organization. Objective SWOT analysis is to recommend strategies to ensure the best alignment between internal and external environment, and choosing the right strategy can be benefi cial organization in order to adapt their strengths to opportunities, minimize risks and eliminate weaknesses.

  6. SWOT ANALYSIS-MANAGEMENT TECHNIQUES TO STREAMLINE PUBLIC BUSINESS MANAGEMENT

    Directory of Open Access Journals (Sweden)

    Rodica IVORSCHI

    2012-06-01

    Full Text Available SWOT analysis is the most important management techniques for understanding the strategic position of an organization.Objective SWOT analysis is to recommend strategies to ensure the best alignment between internal and external environment, and choosing the right strategy can be beneficial organization in order to adapt their strengths to opportunities, minimize risks and eliminate weaknesses.

  7. „Model of Effective Management of Bulgarian Public Administration Managing EU Funds“

    OpenAIRE

    2014-01-01

    The paper analyzes the possibilities of constructing a model for the effective management of the Bulgarian public administration responsible for managing the EU funds amid the global financial crisis by using McKinsey’s 7S model. The change of the management model of the public administration in charge of the absorption of EU funds in Bulgaria would increase the absorption rate of the funds while streamlining budgetary costs on the maintenance of the administration. The aim of the study is to...

  8. The tyrosine 343 residue of nucleophosmin (NPM)-anaplastic lymphoma kinase (ALK) is important for its interaction with SHP1, a cytoplasmic tyrosine phosphatase with tumor suppressor functions.

    Science.gov (United States)

    Hegazy, Samar A; Wang, Peng; Anand, Mona; Ingham, Robert J; Gelebart, Pascal; Lai, Raymond

    2010-06-25

    The cytoplasmic tyrosine phosphatase SHP1 has been shown to inhibit the oncogenic fusion protein nucleophosmin (NPM)-anaplastic lymphoma kinase (ALK), and loss of SHP1 contributes to NPM-ALK-mediated tumorigenesis. In this study, we aimed to further understand how SHP1 interacts and regulates NPM-ALK. We employed an in vitro model in which GP293 cells were transfected with various combinations of NPM-ALK (or mutants) and SHP1 (or mutants) expression vectors. We found that SHP1 co-immunoprecipitated with NPM-ALK, but not the enzymatically inactive NPM-ALK(K210R) mutant, or the mutant in which all three functionally important tyrosine residues (namely, Tyr(338), Tyr(342), and Tyr(343)) in the kinase activation loop (KAL) of ALK were mutated. Interestingly, whereas mutation of Tyr(338) or Tyr(342) did not result in any substantial change in the NPM-ALK/SHP1 binding (assessed by co-immunoprecipitation), mutation of Tyr(343) abrogated this interaction. Furthermore, the NPM-ALK/SHP1 binding was readily detectable when each of the remaining 8 tyrosine residues known to be phosphorylated were mutated. Although the expression of SHP1 effectively reduced the level of tyrosine phosphorylation of NPM-ALK, it did not affect that of the NPM-ALK(Y343F) mutant. In soft agar clonogenic assay, SHP1 expression significantly reduced the tumorigenicity of NPM-ALK but not that of NPM-ALK(Y343F). In conclusion, we identified Tyr(343) of NPM-ALK as the crucial site for mediating the NPM-ALK/SHP1 interaction. Our results also support the notion that the tumor suppressor effects of SHP1 on NPM-ALK are dependent on its ability to bind to this oncogenic protein.

  9. Communication and Conflict Management in Local Public Organizations

    Directory of Open Access Journals (Sweden)

    Gabriela HENER

    2010-06-01

    Full Text Available Intra-organizational conflict within public institutions represents a topic that, until recently, has been rather ignored in Romania. This article is trying to present the multiple role of communication in solving, controlling and preventing conflicts in local public organizations. The paper presents a set of theoretical models (of conflict and communication in organizations and, based on the data offered by an organizational diagnosis-type research, analyzes the role of communication processes in conflict management and prevention.

  10. Public local tax management in Spain: some solidarity proposals for welfare state to the global crisis / La gestión tributaria local en España: algunas propuestas solidarias del estado del bienestar ante la crisis global

    Directory of Open Access Journals (Sweden)

    Irene Belmonte Martín

    2013-10-01

    Full Text Available Local government is a basic mainstay for democratic Welfare States based on principle of maximum closeness to the citizen (subsidiarity. However, municipalities are faced with many problems to make this challenge, including precisely its limited financial capacity and infra municipalism. Therefore, they had to devise new ways to maximize administrative efficiency of tax administration and collection. Following the literature on models of local public service delivery, local tax management provision would be: direct supply by the local administration, delivery through special purpose bodies dependent on the local government, and outsourcing. These formulas, incorporating elements of both the New Public Management (NPM and governance, have been reflected in various models ranging from inter administrative cooperation and supra local organizing skills. The aim of the study is to analyze these formulas for the sake of the principles of Solidarity, Equity and Redistribution. In this sense, municipalities have to maximize tax revenue for effective development of their social policies in the mode of Welfare States increasingly uncertain.

  11. PUBLIC RELATIONS IN PUBLIC ADMINISTRATION: ROLE AND MANAGEMENT, IN A SOCIO-POLITICAL MARKETING CONTEXT

    Directory of Open Access Journals (Sweden)

    Dorian Pocovnicu

    2014-07-01

    Full Text Available Many agree that PR and marketing are at their best when used together, when it comes to local public administration institutions there is the need for both an individual and symbiotic approach of the two. Taking into consideration that public interest organizations act within public space, PR represents a public communication strategy. Thus they present the role of generating a climate and state of social normality and, especially in democratic societies, PR plays the part of generator of communication flows between public institutions, citizens and stakeholders. In a social-political marketing context, envisaged as an aggregate of processes, with a multiple purpose, the generator which is PR must unfold coherently for each of the processes. It is our purpose in this paper to depict the PR role and management in the case of one local public administration institution (Bacau Prefect Institution, in a socio-political marketing context.

  12. Management pattern of ecological public welfare forests in South China

    Institute of Scientific and Technical Information of China (English)

    Chong LOU; Anxing LIU; Guomin ZHU

    2008-01-01

    The characteristics and actualities of ecologi-cal public welfare forests in South China are studied in this paper, including common and special management patterns. The restoration and reconstruction pattern of subtropical evergreen broad-leaved forests, zonal vegeta-tion in the key eco-zone, and the transformation pattern of coniferous and broad-leaved mixed forests in the general eco-zone with multi-forms are discussed in detail. The authors also point out, based on ecological transformation and utilization, that ecological public welfare forests should be oriented to multiple benefit utilization to maintain sustainable management.

  13. Making waste management public (or falling back to sleep)

    Science.gov (United States)

    Lougheed, Scott; Rowe, R Kerry; Kuyvenhoven, Cassandra

    2014-01-01

    Human-produced waste is a major environmental concern, with communities considering various waste management practices, such as increased recycling, landfilling, incineration, and waste-to-energy technologies. This article is concerned with how and why publics assemble around waste management issues. In particular, we explore Noortje Marres and Bruno Latour’s theory that publics do not exist prior to issues but rather assemble around objects, and through these assemblages, objects become matters of concern that sometimes become political. The article addresses this theory of making things public through a study of a small city in Ontario, Canada, whose landfill is closed and waste diversion options are saturated, and that faces unsustainable costs in shipping its waste to the United States, China, and other regions. The city’s officials are undertaking a cost–benefit assessment to determine the efficacy of siting a new landfill or other waste management facility. We are interested in emphasizing the complexity of making (or not making) landfills public, by exploring an object in action, where members of the public may or may not assemble, waste may or may not be made into an issue, and waste is sufficiently routinized that it is not typically transformed from an object to an issue. We hope to demonstrate Latour’s third and fifth senses of politics best account for waste management’s trajectory as a persistent yet inconsistent matter of public concern. PMID:25051590

  14. IT PROJECT PORTFOLIO MANAGEMENT: MODULARITY PROBLEMS IN A PUBLIC ORGANIZATION

    DEFF Research Database (Denmark)

    Hansen, Lars Kristian; Mengiste, Shegaw Anagaw

    2012-01-01

    As today’s public and private sector organizations heavily rely on Information Technology (IT) to provide faster cycle times and better services, IT Project Portfolio Management (IT PPM) has become a high priority issue. This research adopts engaged scholarship to investigate IT PPM practices...... suggest a model addressing the identified problems by organizing IT PPM in three modules connected by three gateways. These results may be used to inform further research into IT PPM and to help managers improve IT PPM practices in public organizations. Keywords: IT Project Portfolio Management (IT PPM......, and (2) what modularity mechanisms can be recommended to improve IT PPM? By drawing on the theory’s distinction between visible information and Hidden design parameters five modularity problems are identified: (1) Lack of operational levels strategies, (2) No systematic approach to manage IT project...

  15. Applying strategic management theories in public sector organizations

    DEFF Research Database (Denmark)

    Hansen, Jesper Rosenberg; Ewan, Ferlie

    2016-01-01

    conditions: the degree of administrative autonomy, performance-based budgeting and market-like competition. We give empirical examples drawn from public servives in the UK and Denmark. We call for more exploration of these (and other) strategic management approaches within contemporary public services...... that possibiliteis for applying these theories vary depending on the type of public organizations involved, and are les appropriate in traditional settings but more relevant in autonomized and market-like service-delivery organizations. We further propose that their increased applicability depends on three specific...

  16. Resource file: practical publications for energy management, edition III

    Energy Technology Data Exchange (ETDEWEB)

    1980-03-01

    The Resource File is an in-depth bibliography of 166 practical and action-oriented energy conservation publications and materials. It is a reference tool, designed for Federal, state, and local energy managers or people who are asked to recommend how-to conservation guides to the public. Each listing describes a publication's intended audience and provides a summary of its contents. Included are operations and maintenance manuals, life-cycle costing handbooks, home insulation manuals, films on fuel-saving driving techniques, and courses devoted exclusively to home weatherization. 166 items.

  17. Emergency Management Operations Process Mapping: Public Safety Technical Program Study

    Science.gov (United States)

    2011-02-01

    DRDC CSS CR 2011-09 i Emergency Management Operations Process Mapping : Public Security Technical Program Study Anet Greenley ...processus/outils). DRDC CSS CR 2011-09 iii Executive summary Emergency Management Operations Process Mapping PSTP Study [ Greenley , A...technique de sécurité publique – Etude DSTP [ Greenley , A.; Poursina, S.]; DRDC CSS CR 2011-09 L’objectif principal du Programme technique de sécurité

  18. Managing retrenchment in French public hospitals: philosophical and regulatory constraints.

    Science.gov (United States)

    Sobczak, P M; Fottler, M D; Chastagner, D

    1988-01-01

    The French hospital system is experiencing economic stresses similar to those experienced by US hospitals. Pressures for cost containment have occurred due to changes in health care funding. The public hospital system is facing unprecedented severe retrenchment. Innovative strategies for managing retrenchment have been restricted by regulatory and philosophical constraints. What is needed is to provide more autonomy for individual hospital managers together with greater accountability for achievement of results.

  19. Oshkosh Logistic Management and Public Relations Responsibilities at NASA Langley

    Science.gov (United States)

    Beck, Danielle

    1995-01-01

    The central focus of my study for the summer of 1995 was to provide logistical support to Margaret Hunt, the logistics manager of the OSHKOSH airshow. In this capacity responsibilities included making arrangements for participants from NASA centers and SBIR companies for their stay in Wisconsin, while visiting the airshow, and managing staff for exhibits and the aerospace theater. A secondary purpose was to serve in other public service capacities by writing news releases, fact sheets, announcements, and articles for the Researcher News.

  20. Successful process management for public utilities; Erfolgreiches Prozessmanagement fuer Stadtwerke

    Energy Technology Data Exchange (ETDEWEB)

    Knipprath, Daniel [projekt:unternehmensberatungsgesellschaft mbH, Muenchen (Germany); Schaefer, Anke [Dr. Schaefer PR- und Strategieberatung, Rostock (Germany)

    2011-06-15

    As a result of regulatory cuts in their revenue structure, public utilities are increasingly compelled to improve their cost efficiency. Furthermore, they have to deal with altered framework conditions of energy procurement as well as the necessity of sustainable customer loyalty management. The example of a regional supplier is used here to show how goal-oriented process management can contribute to securing a sustainable, promising position in the market.

  1. Oncogenic tyrosine kinase NPM-ALK induces expression of the growth-promoting receptor ICOS.

    Science.gov (United States)

    Zhang, Qian; Wang, Hongyi; Kantekure, Kanchan; Paterson, Jennifer C; Liu, Xiaobin; Schaffer, Andras; Paulos, Chrystal; Milone, Michael C; Odum, Niels; Turner, Suzanne; Marafioti, Teresa; Wasik, Mariusz A

    2011-09-15

    Here we report that T-cell lymphoma cells carrying the NPM-ALK fusion protein (ALK(+) TCL) frequently express the cell-stimulatory receptor ICOS. ICOS expression in ALK(+) TCL is moderate and strictly dependent on the expression and enzymatic activity of NPM-ALK. NPM-ALK induces ICOS expression via STAT3, which triggers the transcriptional activity of the ICOS gene promoter. In addition, STAT3 suppresses the expression of miR-219 that, in turn, selectively inhibits ICOS expression. ALK(+) TCL cell lines display extensive DNA methylation of the CpG island located within intron 1, the putative enhancer region, of the ICOS gene, whereas cutaneous T-cell lymphoma cell lines, which strongly express ICOS, show no methylation of the island. Treatment of the ALK(+) TCL cell lines with DNA methyltransferase inhibitor reversed the CpG island methylation and augmented the expression of ICOS mRNA and protein. Stimulation of the ICOS receptor with anti-ICOS antibody or ICOS ligand-expressing B cells markedly enhanced proliferation of the ALK(+) TCL cells. These results demonstrate that NPM-ALK, acting through STAT3 as the gene transcriptional activator, induces the expression of ICOS, a cell growth promoting receptor. These data also show that the DNA methylation status of the intronic CpG island affects transcriptional activity of the ICOS gene and, consequently, modulates the concentration of the expressed ICOS protein.

  2. Atractylodin Inhibits Interleukin-6 by Blocking NPM-ALK Activation and MAPKs in HMC-1.

    Science.gov (United States)

    Chae, Hee-Sung; Kim, Young-Mi; Chin, Young-Won

    2016-09-02

    Atractylodin is one of the major constituents of the rhizome of Atractylodes lancea, which is widely used in Korean traditional medicine as a remedy for the treatment of gastritis and gastric ulcers. Despite of a major constituent of widely used botanical to treat inflammatory responses little is known about anti-inflammatory effect of atractylodin in the human mast cell (HMC-1). Hence, we evaluated the effect of atractylodin on the release of IL-6, the involvement of nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) and mitogen-activated protein kinases (MAPKs) in phorbol-12-myristate-13-acetate and A23187-induced HMC-1. In addition, Janus kinase 2 (JAK2), signal transducer and activator of transcription 3 (STAT3), phospholipase C (PLC) gamma 1, and AKT phosphorylation relevant to NPM-ALK signal pathway were assessed. IL-6 levels in the HMC-1 stimulated by phorbol-12-myristate-13-acetate and A23187 were apparently decreased by the treatment of atractylodin. Concurrently, atractylodin not only inhibited the phosphorylation of NPM-ALK, but also suppressed the phosphorylation of JAK2, STAT3, PLC gamma 1, and AKT. Furthermore, the activated mitogen-activated protein kinases (MAPKs) by phorbol-12-myristate-13-acetate and A23187 were inhibited by atractylodin. These results suggested that atractylodin might have a potential regulatory effect on inflammatory mediator expression through blockade of both the phosphorylation of MAPKs and the NPM-ALK signaling pathway.

  3. Atractylodin Inhibits Interleukin-6 by Blocking NPM-ALK Activation and MAPKs in HMC-1

    Directory of Open Access Journals (Sweden)

    Hee-Sung Chae

    2016-09-01

    Full Text Available Atractylodin is one of the major constituents of the rhizome of Atractylodes lancea, which is widely used in Korean traditional medicine as a remedy for the treatment of gastritis and gastric ulcers. Despite of a major constituent of widely used botanical to treat inflammatory responses little is known about anti-inflammatory effect of atractylodin in the human mast cell (HMC-1. Hence, we evaluated the effect of atractylodin on the release of IL-6, the involvement of nucleophosmin-anaplastic lymphoma kinase (NPM-ALK and mitogen-activated protein kinases (MAPKs in phorbol-12-myristate-13-acetate and A23187-induced HMC-1. In addition, Janus kinase 2 (JAK2, signal transducer and activator of transcription 3 (STAT3, phospholipase C (PLC gamma 1, and AKT phosphorylation relevant to NPM-ALK signal pathway were assessed. IL-6 levels in the HMC-1 stimulated by phorbol-12-myristate-13-acetate and A23187 were apparently decreased by the treatment of atractylodin. Concurrently, atractylodin not only inhibited the phosphorylation of NPM-ALK, but also suppressed the phosphorylation of JAK2, STAT3, PLC gamma 1, and AKT. Furthermore, the activated mitogen-activated protein kinases (MAPKs by phorbol-12-myristate-13-acetate and A23187 were inhibited by atractylodin. These results suggested that atractylodin might have a potential regulatory effect on inflammatory mediator expression through blockade of both the phosphorylation of MAPKs and the NPM-ALK signaling pathway.

  4. Kindermishandeling in Nederland anno 2005 : De nationale prevalentiestudie mishandeling van kinderen en jeugdigen (NPM-2005)

    NARCIS (Netherlands)

    IJzendoorn, M.H.; Prinzie, P.; Euser, E.M.; Groeneveld, M.G.; Brilleslijper-Kater, S.N.; Noort-Van der Linden, A.M.T. van; Bakermans-Kranenburg, M.J.; Juffer, F.; Mesman, J.; Klein Velderman, M.; San Martin Beuk, M.; Ohlsen-Koole, P.C.

    2007-01-01

    Hoeveel kinderen in ons land het slachtoffer worden van mishandeling is niet bekend. Daarom is er is behoefte aan cijfermateriaal over de aard en omvang van de problematiek. Het doel van de NPM-2005 is inzicht te verschaffen in de prevalentie van verschillende typen van kindermishandeling in

  5. 77 FR 70149 - Mid-Atlantic Fishery Management Council (MAFMC); Public Meetings

    Science.gov (United States)

    2012-11-23

    ... National Oceanic and Atmospheric Administration Mid-Atlantic Fishery Management Council (MAFMC); Public... (NOAA), Commerce. ACTION: Notice of public meetings. SUMMARY: The Mid-Atlantic Fishery Management Council (Council) and its Visioning and Strategic Planning ] Working Group will hold public...

  6. National Strategies for Public Library Development

    DEFF Research Database (Denmark)

    Kann-Christensen, Nanna

    2010-01-01

    by The Danish Agency for Libraries and Media, and The Swedish Arts Council, who both administer development grants to public libraries. The paper identifies both differences and similarities in both the means to (the political agendas) and the objectives of governmental influence in the libraries.......The economic rationale of New Public Management (NPM) is used in both Sweden and Denmark in order to employ the national cultural policies in local development projects. The paper discusses two different organizational models that are used in order for the national level to be able to exercise...... policies on the local level are discussed. according to the national goals and cultural policies for libraries. This is done in order to point towards a possible relationship between the political means and ends regarding library development. The two models to be discussed are the systems practiced...

  7. Cell line OCI/AML3 bears exon-12 NPM gene mutation-A and cytoplasmic expression of nucleophosmin.

    Science.gov (United States)

    Quentmeier, H; Martelli, M P; Dirks, W G; Bolli, N; Liso, A; Macleod, R A F; Nicoletti, I; Mannucci, R; Pucciarini, A; Bigerna, B; Martelli, M F; Mecucci, C; Drexler, H G; Falini, B

    2005-10-01

    We recently identified a new acute myeloid leukemia (AML) subtype characterized by mutations at exon-12 of the nucleophosmin (NPM) gene and aberrant cytoplasmic expression of NPM protein (NPMc+). NPMc+ AML accounts for about 35% of adult AML and it is associated with normal karyotype, wide morphological spectrum, CD34-negativity, high frequency of FLT3-ITD mutations and good response to induction therapy. In an attempt to identify a human cell line to serve as a model for the in vitro study of NPMc+ AML, we screened 79 myeloid cell lines for mutations at exon-12 of NPM. One of these cell lines, OCI/AML3, showed a TCTG duplication at exon-12 of NPM. This mutation corresponds to the type A, the NPM mutation most frequently observed in primary NPMc+ AML. OCI/AML3 cells also displayed typical phenotypic features of NPMc+ AML, that is, expression of macrophage markers and lack of CD34, and the immunocytochemical hallmark of this leukemia subtype, that is, the aberrant cytoplasmic expression of NPM. The OCI/AML3 cell line easily engrafts in NOD/SCID mice and maintains in the animals the typical features of NPMc+ AML, such as the NPM cytoplasmic expression. For all these reasons, the OCI/AML3 cell line represents a remarkable tool for biomolecular studies of NPMc+ AML.

  8. Public involvement in adaptive phased management of nuclear waste facilities

    Energy Technology Data Exchange (ETDEWEB)

    Chartrand, D. [Royal Roads Univ., Victoria, British Columbia (Canada); Donev, J. [Univ. of Calgary, Calgary, Alberta (Canada)

    2012-07-01

    If a community is going to host a waste facility that community must be informed about nuclear waste disposal and willing to house the facility permanently. This talk will discuss the process for distributing information to primary and secondary stakeholders; investigate the accessibility and transparency of public information and assess the ability to dialogue between stakeholders when issues are raised in the context of adaptive phased management? We will also examine transparency in the process of managing conflict by looking at some of the issues at hand and how those issues are currently being managed through stakeholder engagement.

  9. Public Facilities Management and Action Research for Sustainability

    DEFF Research Database (Denmark)

    Galamba, Kirsten Ramskov

    practice inspired by the principles of FM. The bottom up change process had an employee perspective, and the work provides answers to the challenges of creating a culture allowing for critical reflections in relation to the impact of FM practice on societal sustainability.......Current work is the main product of a PhD study with the initial working title ‘Sustainable Facilities Management’ at Centre for Facilities Management – Realdania Research, DTU Management 1. December 2008 – 30. November 2011. Here the notion of Public Sustainable Facilities Management (FM...

  10. 77 FR 53179 - North Pacific Fishery Management Council; Public Meeting

    Science.gov (United States)

    2012-08-31

    ... total catch accounting, recruitment and retrospective analyses, a review of the economic stock... National Oceanic and Atmospheric Administration RIN 0648-XC195 North Pacific Fishery Management Council... Administration (NOAA), Commerce. ACTION: Notice of a public meeting. SUMMARY: The North Pacific Fishery...

  11. What Kind of Reflection Do We Need in Public Management?

    DEFF Research Database (Denmark)

    Knassmüller, Monika; Meyer, Renate

    2016-01-01

    in practice. Focusing on three standard configurations – newcomers, experts and line managers in public administration – we illustrate that different types of reflection processes are required to different extents in various practical situations. By this approach we aim to provide a multilayered perspective...

  12. Digging deeper: public housing in Ghana managed by local authorities

    NARCIS (Netherlands)

    Aziabah Akanvose, A.B.; Gruis, V.H.; Elsinga, M.; Van der Flier, C.L.

    2015-01-01

    In the 1980s, the government of Ghana decided to withdraw from direct housing provision. In lieu of this, the two main institutions through which government provided and managed public housing – the TDC and SHC sold off most of their dwellings. The few remaining dwellings were transferred to local a

  13. Verification and Validation of the Public Order Management Serious Game

    NARCIS (Netherlands)

    Voogd, J.

    2014-01-01

    In urban operations, military commanders have to take into account the civilians present in the operation area. This is why Public Order Management (POM) is an important subject of their training. The organization of POM field training is challenging. It requires lots of humans to act as crowds. It

  14. Teaching Classroom Management-- A Potential Public Health Intervention?

    Science.gov (United States)

    Marlow, Ruth; Hansford, Lorraine; Edwards, Vanessa; Ukoumunne, Obioha C; Norman, Shelley; Ingarfield, Sara; Sharkey, Siobhan; Logan, Stuart; Ford, Tamsin

    2015-01-01

    Purpose: The purpose of this paper is to explore the feasibility of a classroom management course as a public health intervention. Improved socio-emotional skills may boost children's developmental and academic trajectory, while the costs of behaviour problems are enormous for schools with considerable impact on others' well-being.…

  15. Public management and performance : a theory of context

    NARCIS (Netherlands)

    O'Toole, Laurence J.; Meier, Kenneth J.

    2013-01-01

    Recent years have seen a substantial growth in the large-N quantitative study of public management and performance. Much of the progress can be attributed to a small number of data sets on local governments in England, Denmark, the Netherlands, and the United States. The range of data sets suggests

  16. Incentives and Their Dynamics in Public Sector Performance Management Systems

    Science.gov (United States)

    Heinrich, Carolyn J.; Marschke, Gerald

    2010-01-01

    We use the principal-agent model as a focal theoretical frame for synthesizing what we know, both theoretically and empirically, about the design and dynamics of the implementation of performance management systems in the public sector. In this context, we review the growing body of evidence about how performance measurement and incentive systems…

  17. Teacher Performance Management in Denver Public Schools. Executive Summary

    Science.gov (United States)

    New Teacher Project, 2010

    2010-01-01

    In the 2008-2009 school year, The New Teacher Project (TNTP) partnered with Denver Public Schools (DPS) and the Denver Classroom Teachers Association (DCTA) to assess the effectiveness of current teacher performance management policies and practices. DPS and the DCTA have been national leaders in their willingness to examine the difficult issues…

  18. Assessment of Corporate Management Practices in Public Universities in Kenya

    Science.gov (United States)

    Waswa, Fuchaka; Ombuki, Charles; Migosi, Joash; Metet, Joseph

    2013-01-01

    In order to continue attracting and retaining high-class intellectual power and hence guarantee quality service delivery, public university management will need to change and adjust in line with increasing local democratisation and globalisation pressures. Scenarios that depict participatory decision-making and respect of divergent viewpoints will…

  19. Public enterprises: Contemporary strategic management and marketing challenges

    Directory of Open Access Journals (Sweden)

    Vesić Dobrica

    2005-01-01

    Full Text Available Modern public companies, organizations and services management is a process that influences certain group, resulting in change of reality or function of it reaching certain, previously set objective. A new philosophy and approach to adaptive creativity, emphasize importance and capabilities of creativity improvement for employees, teams and all organizations.

  20. Improving ICT Management in Public Universities in Kenya

    NARCIS (Netherlands)

    Wanyembi, G.N.W.

    2002-01-01

    With the rapid infusion of information and communication technology (ICT) in Kenya in the recent past, organizations are now realizing the critical role that management, control and maintenance of ICT play in providing and improving ICT services to the user communities. Public universities as agents

  1. 77 FR 66441 - New England Fishery Management Council; Public Meeting

    Science.gov (United States)

    2012-11-05

    ...; Public Meeting AGENCY: National Marine Fisheries Service (NMFS), National Oceanic and Atmospheric... held at the Seaport Hotel, One Seaport Lane, Boston, MA 02210; telephone: (617) 385-4000; fax: (617... Fishery Management Council; telephone: (978) 465-0492. SUPPLEMENTARY INFORMATION: The SSC will meet...

  2. 77 FR 66072 - New England Fishery Management Council; Public Meeting

    Science.gov (United States)

    2012-11-01

    ...; Public Meeting AGENCY: National Marine Fisheries Service (NMFS), National Oceanic and Atmospheric... will be held at the Seaport Hotel, One Seaport Lane, Boston, MA 02210; telephone: (617) 385-4000; fax... Fishery Management Council; telephone: (978) 465-0492. SUPPLEMENTARY INFORMATION: The Scientific...

  3. A Balanced Scorecard Approach to Public Relations Management Assessment.

    Science.gov (United States)

    Fleisher, Craig S.; Mahaffy, Darren

    1997-01-01

    Describes a new managerial approach to assessing public relations/communications (PR/C) performance using a "balanced scorecard." Reviews the current state of PR/C management assessment; illustrates the balanced scorecard framework; highlights its strengths and weaknesses; describes the process of applying the scorecard to PR/C units;…

  4. Managing Public Libraries in the 21st Century.

    Science.gov (United States)

    Woodrum, Pat, Ed.

    1989-01-01

    The 16 articles in this issue focus on planning for future trends in public library administration. Topics discussed include leadership qualities; administrator education; collective bargaining; funding and budgeting; governance; user fees; collection management; community involvement and support; special population groups; services to educational…

  5. Lobatin B inhibits NPM/ALK and NF-κB attenuating anaplastic-large-cell-lymphomagenesis and lymphendothelial tumour intravasation.

    Science.gov (United States)

    Kiss, Izabella; Unger, Christine; Huu, Chi Nguyen; Atanasov, Atanas Georgiev; Kramer, Nina; Chatruphonprasert, Waranya; Brenner, Stefan; McKinnon, Ruxandra; Peschel, Andrea; Vasas, Andrea; Lajter, Ildiko; Kain, Renate; Saiko, Philipp; Szekeres, Thomas; Kenner, Lukas; Hassler, Melanie R; Diaz, Rene; Frisch, Richard; Dirsch, Verena M; Jäger, Walter; de Martin, Rainer; Bochkov, Valery N; Passreiter, Claus M; Peter-Vörösmarty, Barbara; Mader, Robert M; Grusch, Michael; Dolznig, Helmut; Kopp, Brigitte; Zupko, Istvan; Hohmann, Judit; Krupitza, Georg

    2015-01-28

    An apolar extract of the traditional medicinal plant Neurolaena lobata inhibited the expression of the NPM/ALK chimera, which is causal for the majority of anaplastic large cell lymphomas (ALCLs). Therefore, an active principle of the extract, the furanoheliangolide sesquiterpene lactone lobatin B, was isolated and tested regarding the inhibition of ALCL expansion and tumour cell intravasation through the lymphendothelium. ALCL cell lines, HL-60 cells and PBMCs were treated with plant compounds and the ALK inhibitor TAE-684 to measure mitochondrial activity, proliferation and cell cycle progression and to correlate the results with protein- and mRNA-expression of selected gene products. Several endpoints indicative for cell death were analysed after lobatin B treatment. Tumour cell intravasation through lymphendothelial monolayers was measured and potential causal mechanisms were investigated analysing NF-κB- and cytochrome P450 activity, and 12(S)-HETE production. Lobatin B inhibited the expression of NPM/ALK, JunB and PDGF-Rβ, and attenuated proliferation of ALCL cells by arresting them in late M phase. Mitochondrial activity remained largely unaffected upon lobatin B treatment. Nevertheless, caspase 3 became activated in ALCL cells. Also HL-60 cell proliferation was attenuated whereas PBMCs of healthy donors were not affected by lobatin B. Additionally, tumour cell intravasation, which partly depends on NF-κB, was significantly suppressed by lobatin B most likely due to its NF-κB-inhibitory property. Lobatin B, which was isolated from a plant used in ethnomedicine, targets malignant cells by at least two properties: I) inhibition of NPM/ALK, thereby providing high specificity in combating this most prevalent fusion protein occurring in ALCL; II) inhibition of NF-κB, thereby not affecting normal cells with low constitutive NF-κB activity. This property also inhibits tumour cell intravasation into the lymphatic system and may provide an option to manage this

  6. A dynamic management of a public transportation fleet

    Directory of Open Access Journals (Sweden)

    Ireneusz Celiński

    2013-09-01

    Full Text Available Background: The present paper deals with the problems of a public transportation fleet management in public transportation operators. A management concept is proposed based on a real-time acquisition of parameters of public transportation passenger exchange. Methods: The relevant research utilised video materials documenting the processes of passenger exchange in public transportation. The proposed methodology is based on a dynamic real-time measurement of passenger streams. A characteristic feature of the measurement methodology applied is that the data is collected outside the vehicles, with a CCTV camera used per access point. Demand for the public transportation service are calculated using the image processing. Results: The derived demand characteristics allow not only an estimation of the magnitude of traffic streams in public transportation but also their qualitative description. Such an approach permits a flexible design of the transportation offer to adapt to the demand. This allows matching the timetables to the density functions describing the demand for public transportation within the space of transportation networks. In addition, based on the results of this type of research, a public transportation operator may despatch the vehicle base in a flexible way. For each run of a bus or tram fleet, basing on the registered passenger traffic streams, it is possible to rationally despatch the vehicles with suitable capacity. Conclusions: A system of this type is capable of determining the quality of work of the public transportation. With the ITS systems being introduced still more widely, the proposed methodology allows the design and implementation of dynamic timetables.

  7. Social Networking for Emergency Management and Public Safety

    Energy Technology Data Exchange (ETDEWEB)

    Lesperance, Ann M.; Olson, Jarrod; Godinez, Melanie A.

    2010-08-31

    On March 10, 2010 the workshop titled Social Networking for Emergency Management and Public Safety was held in Seattle, WA. The objective of this workshop was to showcase ways social media networking technologies can be used to support emergency management and public safety operations. The workshop highlighted the current state of social networking and where this dynamic engagement is heading, demonstrated some of the more commonly used technologies, highlighted case studies on how these tools have been used in a variety of jurisdictions and engaged the private sector on how these tools might serve as a conduit for two way communication between with the public sector to address regional recovery issues and decision making.

  8. 78 FR 49281 - Trinity Adaptive Management Working Group; Public Meeting, Teleconference and Web-Based Meeting

    Science.gov (United States)

    2013-08-13

    ... Fish and Wildlife Service Trinity Adaptive Management Working Group; Public Meeting, Teleconference and... Trinity Adaptive Management Working Group (TAMWG). DATES: Public meeting, Teleconference, and web-based... Management Working Group (TAMWG) will hold a meeting. Background The TAMWG affords stakeholders...

  9. 78 FR 46361 - Trinity Adaptive Management Working Group; Public Meeting, Teleconference and Web-Based Meeting

    Science.gov (United States)

    2013-07-31

    ... Fish and Wildlife Service Trinity Adaptive Management Working Group; Public Meeting, Teleconference and.... Fish and Wildlife Service, announce a joint meeting between the Trinity Adaptive Management Working Group (TAMWG) and Trinity Management Council (TMC). DATES: Public meeting, Teleconference, and...

  10. 78 FR 35312 - Trinity Adaptive Management Working Group; Public Meeting, Teleconference and Web-Based Meeting

    Science.gov (United States)

    2013-06-12

    ... Fish and Wildlife Service Trinity Adaptive Management Working Group; Public Meeting, Teleconference and... Trinity Adaptive Management Working Group (TAMWG). DATES: Public meeting, Teleconference, and web-based... Management Working Group (TAMWG) will hold a meeting. Background The TAMWG affords stakeholders...

  11. Applying Business Process Re-Engineering to Public Sector as A New Public Management Strategy

    Directory of Open Access Journals (Sweden)

    Ropinder Oberoi

    2013-08-01

    Full Text Available The introduction of Business Process Reengineering (BPR to the public sector follows the much broader trend of New Public Management. BPR in the public sector mostly means amalgamation of business processes, computerization of various activities and removal of some unnecessary ones. BPR assimilates a radical premeditated scheme of business pro-cess reengineering and an additional progressive technique of uninterrupted process improvement with adequate information technology (IT and e-business infrastructure strategies. Public organizations have specific and exclusive features that differentiae-ate them from private sector organizations. Based on the literature review and examining of study find-ings, it is argued that a public sector organization can employ BPR to get better its process and overall organizational performance, if it (1 has accrues a collection of BPR-relevant resources and capabilities; (2 has embarked on BPR with adequate depth and breadth; (3 is developing a post-BPR complementary set of skills, systems and technologies, which are essential to further develop the organizational impact of the BPR; and (4 has successfully mitigated the effects of BPR implementation problems. In addition to its effect on administration and ser-vice delivery processes through reduction of the processing time, work steps and cost of government processes, BPR also contributes to enhancing citizen/customer and employee satisfaction, increasing organizational transparency and responsiveness which have also become an essential objective of New Public Management. Therefore, public sector BPR is emerging as an indispensable to performance of organizations in the developing economy. The essential questions addressed in this paper are: What are the scenario and impending problems of reengineering applications in the public sector? Can it be functional for the public sector in attending to frequent problems blockading bureaucracies of developed and

  12. Management of Labor Conflicts in Public Health Organizations

    Directory of Open Access Journals (Sweden)

    Adriana Elena Belu

    2012-05-01

    Full Text Available The work “Management of labor conflicts in public health organizations” treats a very importantissue, of the present, with extensive and multiple implications for public health. The work can be consideredas an interdisciplinary study justified by two arguments: first, it is essential to applied research step, theknowledge and use of enshrined informational content in management literature, especially of models andmechanisms of managerial activity on the administration of human resources, managerial style, mobilizationcapacities, communication, coordination or decision ones and, not least the mechanisms characteristic tocollective relations established between managers and employees; second, it is required for theimplementation phase of research findings, capitalization of an informational sphere of law field, specifically,labor law, because labor conflicts are based both on specific regulations of labor law and on a juridicalliterature, of great interest and of strict use for a concrete optimization of labor social relations.

  13. Public concerns and behaviours towards solid waste management in Italy.

    Science.gov (United States)

    Sessa, Alessandra; Di Giuseppe, Gabriella; Marinelli, Paolo; Angelillo, Italo F

    2010-12-01

    A self-administered questionnaire investigated knowledge, perceptions of the risks to health associated with solid waste management, and practices about waste management in a random sample of 1181 adults in Italy. Perceived risk of developing cancer due to solid waste burning was significantly higher in females, younger, with an educational level lower than university and who believed that improper waste management is linked to cancer. Respondents who had visited a physician at least once in the last year for fear of contracting a disease due to the non-correct waste management had an educational level lower than university, have modified dietary habits for fear of contracting disease due to improper waste management, believe that improper waste management is linked to allergies, perceive a higher risk of contracting infectious disease due to improper waste management and have participated in education/information activities on waste management. Those who more frequently perform with regularity differentiate household waste collection had a university educational level, perceived a higher risk of developing cancer due to solid waste burning, had received information about waste collection and did not need information about waste management. Educational programmes are needed to modify public concern about adverse health effects of domestic waste.

  14. Innovation in the Public Sector: Public Managers Challenges and Future Prospects

    Directory of Open Access Journals (Sweden)

    Dan Florin STANESCU

    2009-01-01

    Full Text Available Public managers are graduated young people who passed trough an accelerated development program preparing them for careers at the highest levels of the Civil Service. Civil Service fast streamers are exposed to a range of placements in government departments and agencies and they are placed in regularly changing roles of intensive responsibility to prepare them for future senior managerial positions. Methodology: Interviews with major stakeholders took place in order to find out their opinions on the overall impact of public managers on the Romanian Civil Service over the last 3 years. More than 25 senior civil servants and 40 Public Managers were interviewed using both face to face and phone interviews. The research is the more important as the studies on the subject are almost inexistent and it approaches a group of people being in essence, policy advisers, project leaders, experts, liaison and many other job titles all in one. Therefore, it is highly important to understand the challanges and future prospects of those Public Managers as they represent a group of people able to meet the fresh challanges that come from the rapidly changing business and political environment.

  15. The Public Manager, the Structure of Public Institution, and Implementation: The 2002-2012 Finnish Senior Bureaucratic Manager Reform

    Science.gov (United States)

    Mukhtar, Mohammed Ibn

    2015-01-01

    Public management and administration today is about crafting, structuring and instituting. Structuration is a very integral part of all organisations. Unlike the gradualist approach, structural reform transforms the dominant system touching on main elements. Structural reform had largely come and gone without necessarily touching on some public…

  16. Social Impact Management Plans: Innovation in corporate and public policy

    Energy Technology Data Exchange (ETDEWEB)

    Franks, Daniel M., E-mail: d.franks@uq.edu.au [Centre for Social Responsibility in Mining, The University of Queensland, Sustainable Minerals Institute, St Lucia, Brisbane, Queensland 4072 (Australia); Vanclay, Frank, E-mail: frank.vanclay@rug.nl [Department of Cultural Geography, Faculty of Spatial Sciences, The University of Groningen, P.O. Box 800, 9700 AV Groningen (Netherlands)

    2013-11-15

    Social Impact Assessment (SIA) has traditionally been practiced as a predictive study for the regulatory approval of major projects, however, in recent years the drivers and domain of focus for SIA have shifted. This paper details the emergence of Social Impact Management Plans (SIMPs) and undertakes an analysis of innovations in corporate and public policy that have put in place ongoing processes – assessment, management and monitoring – to better identify the nature and scope of the social impacts that might occur during implementation and to proactively respond to change across the lifecycle of developments. Four leading practice examples are analyzed. The International Finance Corporation (IFC) Performance Standards require the preparation of Environmental and Social Management Plans for all projects financed by the IFC identified as having significant environmental and social risks. Anglo American, a major resources company, has introduced a Socio-Economic Assessment Toolbox, which requires mine sites to undertake regular assessments and link these assessments with their internal management systems, monitoring activities and a Social Management Plan. In South Africa, Social and Labour Plans are submitted with an application for a mining or production right. In Queensland, Australia, Social Impact Management Plans were developed as part of an Environmental Impact Statement, which included assessment of social impacts. Collectively these initiatives, and others, are a practical realization of theoretical conceptions of SIA that include management and monitoring as core components of SIA. The paper concludes with an analysis of the implications for the practice of impact assessment including a summary of key criteria for the design and implementation of effective SIMPs. -- Highlights: • Social impact management plans are effective strategies to manage social issues. • They are developed in partnership with regulatory agencies, investors and community.

  17. Public Intellectuals vs. New Public Management: The Defeat of Public Engagement in Higher Education

    Science.gov (United States)

    Watermeyer, Richard

    2016-01-01

    Much is written apropos a rationalization for public engagement in science and technology (PEST). Less copious is a literature that considers PEST in a broader form and operationalized in the specific environment of higher education and the impact of its undertaking on the working lives of academics. This paper considers the status of public…

  18. South African managers in public service: On being authentic

    Directory of Open Access Journals (Sweden)

    Antoni Barnard

    2014-01-01

    Full Text Available South African managers in public service consistently face challenges related to managing a well-adjusted and productive diverse workforce. Following the notion that leadership authenticity fosters positive psychological employee capacity, the aim of this study was to explore the meaning essence of authenticity as lived in the work–life experiences of senior managers in public service. Five senior managers in public service were purposefully selected based on their articulated challenges with being authentic at work, whilst attending a diversity sensitivity workshop. From a hermeneutic phenomenological perspective, in-depth interviews were used, and an interpretative phenomenological analysis yielded two predominant themes offering a description of what it means to be authentic. Authenticity is experienced as an affective state that results from a continuous self-appraisal of the extent to which expression of self is congruent with a subjective and socially constructed expectation of self in relation to others. Authenticity seems to develop through a continuous process of internal and external adaptation, and it leads to ultimately building a differentiated yet integrated identity of self. A reciprocal dynamic between feeling authentic and self-confidence alludes to the potential importance of authenticity dynamics in identity work.

  19. South African managers in public service: on being authentic.

    Science.gov (United States)

    Barnard, Antoni; Simbhoo, Nirvana

    2014-01-01

    South African managers in public service consistently face challenges related to managing a well-adjusted and productive diverse workforce. Following the notion that leadership authenticity fosters positive psychological employee capacity, the aim of this study was to explore the meaning essence of authenticity as lived in the work-life experiences of senior managers in public service. Five senior managers in public service were purposefully selected based on their articulated challenges with being authentic at work, whilst attending a diversity sensitivity workshop. From a hermeneutic phenomenological perspective, in-depth interviews were used, and an interpretative phenomenological analysis yielded two predominant themes offering a description of what it means to be authentic. Authenticity is experienced as an affective state that results from a continuous self-appraisal of the extent to which expression of self is congruent with a subjective and socially constructed expectation of self in relation to others. Authenticity seems to develop through a continuous process of internal and external adaptation, and it leads to ultimately building a differentiated yet integrated identity of self. A reciprocal dynamic between feeling authentic and self-confidence alludes to the potential importance of authenticity dynamics in identity work.

  20. Prioritizing lean management practices in public and private hospitals.

    Science.gov (United States)

    Hussain, Matloub; Malik, Mohsin

    2016-05-16

    Purpose - The purpose of this paper is to prioritize 21 healthcare wastes in public and private hospitals of United Arab Emirates (UAE). Design/methodology/approach - Seven healthcare wastes linked with lean management are further decomposed in to sub-criteria and to deal with this complexity of multi criteria decision-making process, analytical hierarchical process (AHP) method is used in this research. Findings - AHP framework for this study resulted in a ranking of 21 healthcare wastes in public and private hospitals of UAE. It has been found that management in private healthcare systems of UAE is putting more emphasis on the inventory waste. On the other hand, over processing waste has got highest weight in public hospitals of UAE. Research limitations/implications - The future directions of this research would be to apply a lean set of tools for the value stream optimization of the prioritized key improvement areas. Practical implications - This is a contribution to the continuing research into lean management, giving practitioners and designers a practical way for measuring and implementing lean practices across health organizations. Originality/value - The contribution of this research, through successive stages of data collection, measurement analysis and refinement, is a set of reliable and valid framework that can be subsequently used in conceptualization, prioritization of the waste reduction strategies in healthcare management.

  1. Nucleophosmin1胞浆表达的结肠癌组织中不存在其第12外显子突变%Non-presence of mutations in exon 12 of nucleophosmin1 (NPM1) gene in colorectal carcinomas with NPM1 expression in cytoplasm

    Institute of Scientific and Technical Information of China (English)

    杨宇峰; 张锡迎; 杨梅; 谢树瑞; 张宝庭

    2014-01-01

    Objective To investigate whether there is a presence of mutations in exon 12 of nucleophosmin1 (NPM1) gene in colorectal carcinomas (CRC). Methods We investigated NPM expression by immunohistochemis-try in histologically normal to malignant colorectal tissues and also investigate whether exon 12 of the NPM1 gene is mutated in CRC with NPM expression located in cytoplasm. Results Among the 115 samples of colorectal carcino-mas, 92.1% (106/115) of the tumors showed NPM1-positive expression only in the nucleus, 7.0% (8/115) showed NPM1-positive expression in cytoplasm, and 0.9%(1/115) showed NPM1-negative expression in cytoplasm and nucle-us. NPM expression was found significantly up-regulated in CRC compared to adjacent colorectal tissue, villous ade-noma, tubular adenoma and normal colorectal tissues, respectively (P<0.05 for all). Sequencing of exon 12 of NPM1 gene in CRC was the same as those in normal colorectal tissue. Conclusion NPM expression is found significantly up-regulated in CRC, suggesting that NPM contributes to oncogenesis of CRC. However, NPM1 exon 12 is not mutat-ed in CRC, which suggests that NPM1 play a role in the tumorigenesis of CRC through unclear mechanisms rather than NPM1 mutation.%目的:观察Nucleophosmin1(NPM1)在结肠癌组织中是否存在NPM1基因第12外显子突变。方法免疫组化检测115例结肠癌组织及相应癌旁组织、10例结肠绒毛状腺瘤、10例管状腺瘤和10例正常结肠黏膜组织NPM1表达;检查NPM1胞浆表达的结肠癌组织中是否存在NPM1基因第12外显子突变。结果在115例结肠癌样本中有92.1%(106/115)的病例NPM1表达定位于胞核,7.0%(8/115)的病例存在胞浆NPM1表达,0.9%(1/115)的病例胞核与胞浆NPM1阴性表达;NPM1在结肠癌组织中呈高表达,并且明显高于在相应癌旁组织、绒毛状腺瘤、管状腺瘤和正常结肠黏膜组织的表达(P均<0.05)。结肠癌组织中NPM1第12外显子结构与正常黏膜野生型NPM

  2. Working in the Public Sector. Introduction to the Thematic Issue

    Directory of Open Access Journals (Sweden)

    Annette Kamp

    2013-05-01

    Full Text Available Work in the public sector has been changing dramatically in recent decades. Reforms aimed at increasing the efficiency of public services have been extensive in the Nordic countries and elsewhere since the 1980s. The reforms and changes have to a large extent been associated with so-called New Public Management (NPM principles, emphasizing the market as a central coordination mechanism. Consequently, public institutions have been restructured, their services are standardized and commodified, and market-like relationships between them have been created. In order to create markets and transform citizens into customers on a market, outsourcing and privatization have been stimulated (Blomqvist & Rothstein 2000, Busch et al 2005, Christensen & Lægreid 2007, Greve 2003. At the same time, traditional Weberian bureaucratic principles are still viable and even enhanced within the sector, for instance, as a consequence of the use of contracts as a means of managing public organizations (Greve 2008. Lately, large reforms aimed at centralized coordination of different service providers, such as the integration of the Norwegian welfare administration, have been labeled post-NPM reforms by some researchers. The implication of all these parallel tendencies is that the institutional and organizational landscape surrounding the work situations of employees in the public sector have become increasingly complex, some call them hybrid,  putting a variety of conflicting pressures on the performance of work within the sector (Christensen & Lægreid 2011, Hasselbladh et al. 2008. In this special issue, we explore some of the consequences of these structural and normative changes on the work of public sector employees in different sectors and contexts (...

  3. Attempt to promote hospital management by IM Public Platform

    Directory of Open Access Journals (Sweden)

    Hui CHEN

    2014-06-01

    Full Text Available Thisarticle has analyzed the contribution of modern IT to hospital management: using public platform of IM (instant message/communication will make it more convenient and efficient to conduct communication with (prior to the treatment, conduct treatment, and provide post-treatment service for patients and their family; withthe set-up of a smooth and efficient information channel set up, the relationship between patients and doctors will be greatly improved ,thus reputation and credibility of the hospital and its doctors will be promoted; when the public has better received the hospital and its doctors, social harmony will be achieved. 

  4. Managing Effective Organization: Public Administration and the Competing Values Approach

    Directory of Open Access Journals (Sweden)

    John ROHRBAUGH

    1999-01-01

    Full Text Available As we begin to develop the curriculum of public administration for the next century, one fundamental question remains unanswered. By what standards do we judge the effectiveness of government agencies? Our students will be leading some of the most important organizations in their countries, if not in the world. Our charge is to prepare them for distinguished management careers in which through thoughtful redesign they will be responsible for the creation of far better organizational structures and processes than existed in this decade or the last. To design curriculum appropriate to this challenge, we must be guided by a better understanding of effective and ineffective performance in the public sector.

  5. Management accounting versus medical profession discourse

    DEFF Research Database (Denmark)

    Malmmose, Margit

    2015-01-01

    of this domination; the absence of physicians in the general public debate, the creation of a phantom phenomenon meaning that the negative consequences of the reform are blamed on a third person, typically the system, and finally a changing meaning of the health care service quality provided from a medical......This study uses discourse, ideology and hegemony as a theoretical foundation to investigate the development of the polarised discourses of management accounting and the medical profession during the introduction of a NPM reform in the public health care debate, using Denmark as a case study. 194...... newspaper articles and 73 medical profession articles from 2002 to 2008 are analysed, using critical discourse analysis. The analysis shows that the management accounting discourse becomes the dominating ideology which is embedded in the public rhetorical debate. There are three peculiar outcomes...

  6. PUBLIC DEBT MANAGEMENT UNDER PRIORITIES OF THE DEBT POLICY OF UKRAINE

    Directory of Open Access Journals (Sweden)

    Y. Kolobov

    2014-01-01

    Full Text Available This paper examines existing methods of public debt management, features of their application, the problem of high levels of public debt and the efficiency of public debt management in Ukraine. Priorities debt policy of Ukraine in the context of the main methods are proposed for public debt management.

  7. Training Middle Managers of South African Public Schools in Leadership and Management Skills

    Science.gov (United States)

    Mampane, Sharon Thabo

    2017-01-01

    The purpose of this conceptual explanatory research is to highlight the importance of training of Middle Managers or Heads of Department (HoDs) in leadership and management in South African public schools. Leadership responsibilities in schools are becoming more complex to the extent that principals can no longer be sole leaders in schools. The…

  8. Managing the financial challenges of public-private collaboration.

    Science.gov (United States)

    Kirk, R

    1995-01-01

    With the growing emphasis on Medicaid managed care waivers as a method for states to constrain healthcare cost overruns (see also State Policy Review on page 63), new and creative pricing techniques for carve-out and carve-in programs will be a key to their success. The author builds on his experience in developing a Medicaid behavioral healthcare carve-out in Massachusetts to illustrate some basic principles in the pricing and management of such public-private collaborations. These collaborative systems should be based on specific actuarial models, plans for enhanced access to services and the need to change incrementally in the context of the political process.

  9. Assessment of public perception of radioactive waste management in Korea.

    Energy Technology Data Exchange (ETDEWEB)

    Trone, Janis R.; Cho, SeongKyung (Myongji University, Korea); Whang, Jooho (Kyung Hee University, Korea); Lee, Moo Yul

    2011-11-01

    The essential characteristics of the issue of radioactive waste management can be conceptualized as complex, with a variety of facets and uncertainty. These characteristics tend to cause people to perceive the issue of radioactive waste management as a 'risk'. This study was initiated in response to a desire to understand the perceptions of risk that the Korean public holds towards radioactive waste and the relevant policies and policy-making processes. The study further attempts to identify the factors influencing risk perceptions and the relationships between risk perception and social acceptance.

  10. Adaptive management: a paradigm for remediation of public facilities

    Energy Technology Data Exchange (ETDEWEB)

    Janecky, David R [Los Alamos National Laboratory; Whicker, Jeffrey J [Los Alamos National Laboratory; Doerr, Ted B [NON LANL

    2009-01-01

    Public facility restoration planning traditionally focused on response to natural disasters and hazardous materials accidental releases. These plans now need to integrate response to terrorist actions. Therefore, plans must address a wide range of potential vulnerabilities. Similar types of broad remediation planning are needed for restoration of waste and hazardous material handling areas and facilities. There are strong similarities in damage results and remediation activities between unintentional and terrorist actions; however, the uncertainties associated with terrorist actions result in a re-evaluation of approaches to planning. Restoration of public facilities following a release of a hazardous material is inherently far more complex than in confined industrial settings and has many unique technical, economic, social, and political challenges. Therefore, they arguably involve a superset of drivers, concerns and public agencies compared to other restoration efforts. This superset of conditions increases complexity of interactions, reduces our knowledge of the initial conditions, and even condenses the timeline for restoration response. Therefore, evaluations of alternative restoration management approaches developed for responding to terrorist actions provide useful knowledge for large, complex waste management projects. Whereas present planning documents have substantial linearity in their organization, the 'adaptive management' paradigm provides a constructive parallel operations paradigm for restoration of facilities that anticipates and plans for uncertainty, multiple/simUltaneous public agency actions, and stakeholder participation. Adaptive management grew out of the need to manage and restore natural resources in highly complex and changing environments with limited knowledge about causal relationships and responses to restoration actions. Similarities between natural resource management and restoration of a facility and surrounding area

  11. Incidence and significance of FLT3-ITD and NPM1 mutations in patients with normal karyotype acute myeloid leukaemia.

    LENUS (Irish Health Repository)

    Haslam, K

    2012-02-01

    BACKGROUND: Acute myeloid leukaemia (AML) is a heterogeneous clonal disorder of haematopoietic progenitor cells. Approximately half of all adult AML patients have a normal karyotype (NK-AML) and an intermediate risk prognosis. AIMS: To determine the incidence and prognostic significance of NPM1 and FLT3-ITD mutations in a population of patients with NK-AML. METHODS: FLT3-ITD and NPM1 mutation status was retrospectively sought in presentation samples from 44 NK-AML patients. RESULTS: FLT3-ITD and NPM1 mutations were detected in 45.5 and 54.5% of patients, respectively, allowing stratification according to genotype. CONCLUSIONS: FLT3-ITD and NPM1 mutation status can be defined in NK-AML. Prospective screening for these mutations is advocated in all NK-AML patients, as the genotype is of clinical importance when considering treatment options including stem cell transplantation.

  12. Critical systems for public health management of floods, North Dakota.

    Science.gov (United States)

    Wiedrich, Tim W; Sickler, Juli L; Vossler, Brenda L; Pickard, Stephen P

    2013-01-01

    Availability of emergency preparedness funding between 2002 and 2009 allowed the North Dakota Department of Health to build public health response capabilities. Five of the 15 public health preparedness capability areas identified by the Centers for Disease Control and Prevention in 2011 have been thoroughly tested by responses to flooding in North Dakota in 2009, 2010, and 2011; those capability areas are information sharing, emergency operations coordination, medical surge, material management and distribution, and volunteer management. Increasing response effectiveness has depended on planning, implementation of new information technology, changes to command and control procedures, containerized response materials, and rapid contract procedures. Continued improvement in response and maintenance of response capabilities is dependent on ongoing funding.

  13. TRANSFERABILITY OF ADMINISTRATIVE REFORMS: NEW PUBLIC MANAGEMENT AS AN EXAMPLE

    OpenAIRE

    KAPUCU, Naim; Kösecik, Muhammet

    2017-01-01

    This article begins with the examination of models of analyzing the process of policy transfer, lesson drawing and policy streams with regard to initiating and directing factors and dynamics of the process. The paper continues with the assessment of administrative reform transferring by evaluating the necessity, major themes and transferability of administrative reform. Strategies for successful administrative reform transferring are emphasized. Special reference is given to New Public Manage...

  14. A WiFi public address system for disaster management.

    Science.gov (United States)

    Andrade, Nicholas; Palmer, Douglas A; Lenert, Leslie A

    2006-01-01

    The WiFi Bullhorn is designed to assist emergency workers in the event of a disaster situation by offering a rapidly configurable wireless of public address system for disaster sites. The current configuration plays either pre recorded or custom recorded messages and utilizes 802.11b networks for communication. Units can be position anywhere wireless coverage exists to help manage crowds or to recall first responders from dangerous areas.

  15. Cluster Policy As an Instrument of Public Management: Regional Aspect

    Directory of Open Access Journals (Sweden)

    Cherkasova Tatiana, P.

    2016-07-01

    Full Text Available The paper presents the research results related to the effectiveness of the new public management instruments of innovative development, which is a regional cluster policy. The experience of implementation of cluster policy in the Rostov region is analyzed, problems are identified and priorities are defined, the solution of which will allow to increase the competitiveness of the region. The identified problems should be carried out in two stages: at the first stage (2016–2017 it is important to complete the implementation of measures to improve the regulatory framework of the Rostov region in the field of cluster and innovation development, investment and socio-economic policy; in the second (2018–2020 to conduct activities aimed at the formation of public authorities of the region a favorable economic and legal conditions for development of cluster infrastructure. Scheme of innovation cluster with government participation that satisfies the principles of public administration is proposed.

  16. 75 FR 39036 - Public Housing Assessment System (PHAS): Management Operations Certification

    Science.gov (United States)

    2010-07-07

    ... URBAN DEVELOPMENT Public Housing Assessment System (PHAS): Management Operations Certification AGENCY... of all major areas of a participant's management operations. The information is used to assess the...) submit management information for evaluation of all major areas of a participant's management...

  17. A new mode of organizing in health care? Governmentality and managed networks in cancer services in England.

    Science.gov (United States)

    Ferlie, Ewan; McGivern, Gerry; Fitzgerald, Louise

    2012-02-01

    We explore the argument that a new mode of health care organizing is emerging which moves beyond the established professional dominance versus New Public Management (NPM) debate. We review Foucault's work on 'governmentality', as applied to health care organizations. We specify two specific Foucauldian themes (the power/knowledge nexus in Evidence Based Medicine (EBM); and the technologies of the clinical managerial self) to analyse organizing in the English cancer services field. We introduce two qualitative case studies of Managed Cancer Networks. We suggest their governance can be fruitfully seen through a 'governmentality' lens. We consider implications for developing Foucauldian analysis of health care organizations.

  18. Managing IT Projects in Public Companies: A Case Study

    Directory of Open Access Journals (Sweden)

    Bouras, A.

    2014-07-01

    Full Text Available As part of its public sector modernization effort, a North African government has put a lot of effort and allocated significant budgets since 1997 to modernize one of its main public sector companies. Consequently, this company, that mainly offers postal services, initiated many IT-based projects to computerize all paper-based ongoing services offered through its branches and to present new products to customers. This company was aiming to improve service quality and to diversify the range of its services. However, some of these IT-based projects inevitably faced problems. Some projects were either not completed successfully, cancelled, over-budget or taking more time than scheduled. As a result, many employees and customers of this company were dissatisfied and complained about bad planning, slowness and significant disruptions in these projects, an event that affected adversely the quality of service. This study aims at determining the causes of these project disruptions, failures or delays. To achieve this aim, 30 experienced project developers and engineers working in that company’s IT department volunteered to respond to a detailed questionnaire specifically developed for this purpose. The questionnaire included questions about project vision clarity, time/cost management, project quality assurance, risk management and human resources management. Results show that the main reasons for disruptions, failure or delays in IT projects are lack of business plan and poor documentation during and after finishing projects, lack of clear quality assurance criteria, standards and reviews, and poor project risk management practices. Ramifications of such results in terms of improving IT project management practices in the public service sector are finally presented.

  19. A new transcriptional variant and small azurophilic granules in an acute promyelocytic leukemia case with NPM1/RARA fusion gene.

    Science.gov (United States)

    Kikuma, Tomoe; Nakamachi, Yuji; Noguchi, Yoriko; Okazaki, Yoko; Shimomura, Daisuke; Yakushijin, Kimikazu; Yamamoto, Katsuya; Matsuoka, Hiroshi; Minami, Hironobu; Itoh, Tomoo; Kawano, Seiji

    2015-12-01

    We report here the first case of NPM1/RARA-positive acute promyelocytic leukemia (APL) preceded by myeloid sarcoma (MS) in the vertebra. A 52-year-old man was diagnosed with MS, as the tumor cells were positive for myeloperoxidase and CD68 but negative for CD163. After treatment with steroids and radiation, the size of the tumor was markedly reduced and peripheral blood count was normal. Bone marrow examination showed 89.2% consisted of unclassified promyelocytes characterized by round nuclei and abundant small azurophilic granules but no Auer rods. The results of chromosome analysis showed 46,XY,t(5;17)(q35;q12). Reverse-transcription polymerase chain reaction amplified the NPM1/RARA fusion transcripts derived from a combination of NPM1 exon 4 and RARA exon 5, or of NPM1 exon 1 and RARA exon 5; the latter of these has not been reported previously. Electron microscopic examination of the promyelocyte nuclei showed they were oval with mild nuclear chromatin condensation and small- to medium-sized nucleoli. Hematological and molecular complete remission was attained after induction therapy including all-trans retinoic acid. As MS was also diagnosed in two of the seven other reported cases of APL with NPM1/RARA, MS may occur more frequently in APL with NPM1/RARA than APL with PML/RARA.

  20. TAT-mediated intracellular delivery of NPM-derived peptide induces apoptosis in leukemic cells and suppresses leukemogenesis in mice.

    Science.gov (United States)

    Zhou, Yun; Du, Wei; Koretsky, Tara; Bagby, Grover C; Pang, Qishen

    2008-09-15

    Nucleophosmin (NPM) is frequently overexpressed in leukemias and other tumors. NPM has been reported to suppress oncogene-induced senescence and apoptosis and may represent a therapeutic target for cancer. We fused a NPM-derived peptide to the HIV-TAT (TAT-NPMDeltaC) and found that the fusion peptide inhibited proliferation and induced apoptotic death of primary fibroblasts and preleukemic stem cells. TAT-NPMDeltaC down-regulated several NF-kappaB-controlled survival and inflammatory proteins and suppressed NF-kappaB-driven reporter gene activities. Using an inflammation-associated leukemia model, we demonstrate that TAT-NPMDeltaC induced proliferative suppression and apoptosis of preleukemic stem cells and significantly delayed leukemic development in mice. Mechanistically, TAT-NPMDeltaC associated with wild-type NPM proteins and formed complexes with endogenous NPM and p65 at promoters of several antiapoptotic and inflammatory genes and abrogated their transactivation by NF-kappaB in leu-kemic cells. Thus, TAT-delivered NPM peptide may provide a novel therapy for inflammation-associated tumors that require NF-kappaB signaling for survival.

  1. Stress among public middle managers dealing with reforms.

    Science.gov (United States)

    Giauque, David

    2016-11-21

    Purpose The purpose of this paper is to identify social and organizational antecedents of stress. This paper also investigates whether attitudes toward organizational changes and reforms might explain stress perception (SP) and mediate the relationships between social and organizational job characteristics and SP. Design/methodology/approach A quantitative approach is used to identify the relationships between the research variables. The investigated population is composed of middle managers working in Swiss public hospitals ( n=720), which are currently being confronted by major reforms. Findings The findings show that perceived social support (work relationships with and support from colleagues), as well as several job characteristics (autonomy in performing tasks, flexibility in the organization of working time, degree of conflict) are significantly related to SP. Moreover, positive attitudes toward change are negatively related to stress, and mediate the relationships between perceived social support as well as job characteristics and SP. Practical implications This paper sheds light on several job characteristics which could contribute to mitigating SP among middle managers. The findings could therefore guide HRM specialists in their efforts to create a favorable work environment so as to facilitate middle managers' activities. Originality/value The innovation of this paper is grounded in the specific population the author investigate, as the empirical inquiry concerns middle managers working in public hospitals. Moreover, this research highlights the central role of job characteristics and attitudes toward change in explaining SP.

  2. The Quality of Higher Education in Public Administration in Thailand: the Side-Effects of Administrative Reform

    Directory of Open Access Journals (Sweden)

    AMPORN TAMRONGLAK

    2016-02-01

    Full Text Available Since the current quality framework, called Thailand Qualification Frameworks for Higher Education (TQF-HEd, has been enforced in the past years by the Office ofthe Higher Education Commission (OHEC, the quality of the graduates produced and the quality of teaching Public Administration particularly graduate study seems to be in the opposite directions. This paper investigates the quality of higher education in Public Administration at Master level in Thailand. Data such as curriculums, program philosophy, etc. were collected from universities offering graduate study in Public Administration. In-depth interviews were conducted from public and private universities. In the midst of the Administrative Reform in Thailand during the economic crisis in 1997, the author analyzed the impacts of the reform, particularly the influential practice of New Public Management (NPM, on the quality of teaching graduate study in Public Administration in Thailand.

  3. NPM阻燃聚丙烯的研究%Study on NPM Flame-Retardant Polypropylene

    Institute of Scientific and Technical Information of China (English)

    梁静; 王新龙; 文小文

    2007-01-01

    通过氧指数(LOI)、水平燃烧(HB)、热重分析(TGA)、扫描电镜(SEM)和红外(IR)等表征方法,研究了单组分膨胀型阻燃剂新戊二醇磷酸脂三聚氰胺盐(NPM)阻燃PP体系的阻燃性能、燃烧发层结构及阻燃机理,评价了NPM的添加量对体系物理性能的影响.结果表明:PP/NPM(100/30)体系的氧指数为26.8%,600℃时的成炭率为8.30%,NPM显著提高了体系的热稳定性.

  4. Anti-ALK Antibodies in Patients with ALK-Positive Malignancies Not Expressing NPM-ALK.

    Science.gov (United States)

    Damm-Welk, Christine; Siddiqi, Faraz; Fischer, Matthias; Hero, Barbara; Narayanan, Vignesh; Camidge, David Ross; Harris, Michael; Burke, Amos; Lehrnbecher, Thomas; Pulford, Karen; Oschlies, Ilske; Siebert, Reiner; Turner, Suzanne; Woessmann, Wilhelm

    2016-01-01

    Patients with Nucleophosmin (NPM)- Anaplastic Lymphoma Kinase (ALK) fusion positive Anaplastic Large Cell Lymphoma produce autoantibodies against ALK indicative of an immune response against epitopes of the chimeric fusion protein. We asked whether ALK-expression in other malignancies induces specific antibodies. Antibodies against ALK were detected in sera of one of 50 analysed ALK-expressing neuroblastoma patients, 13 of 21 ALK positive non-small cell lung carcinoma (NSCLC) patients, 13 of 22 ALK translocation-positive, but NPM-ALK-negative lymphoma patients and one of one ALK-positive rhabdomyosarcoma patient, but not in 20 healthy adults. These data suggest that boosting a pre-existent anti-ALK immune response may be more feasible for patients with ALK-positive NSCLC, lymphomas and rhabdomyosarcomas than for tumours expressing wild-type ALK.

  5. Internal Communication in the Public Management: The Case of a Brazilian Federal Public Authority

    Directory of Open Access Journals (Sweden)

    Priscila Reinaldo Marson

    2013-03-01

    Full Text Available The intention of this article is to present a case study on the adoption and use of new channels of internal communication in a federal public autarchy. The study was conducted at the National Institute of Social Security, in São Paulo, between July 2008 and July 2009, and aimed to monitor the period in which a new internal communication plan was developed and implemented in its initial phase. The research methodology used was the case study, consisting of documentary analysis, field research and in-depth interviews conducted with the institution’s public employees. As a result, it was possible to observe the internal resistance and the difficulties encountered in the management of the new plan. Among its conclusions, the study highlights the need for a previous study on the conditions of relationships and practices developed in a public service unit at the adoption of new communication tools. It also highlights the importance of planning and management actions in the implementation of the intended communication actions, including internal marketing efforts to sensitize users about the meaning and importance of internal communication in promoting greater agility and efficiency in the workplace, in order to offer best public services to users.

  6. NPM1 mutation is a stable marker for minimal residual disease monitoring in acute myeloid leukaemia patients with increased sensitivity compared to WT1 expression*

    DEFF Research Database (Denmark)

    Kristensen, Thomas; Møller, Michael B; Friis, Lone;

    2011-01-01

    Mutation in the NPM1 gene occurs in 60% of acute myeloid leukaemia (AML) patients with normal karyotype. NPM1 mutation is potentially a superior minimal residual disease (MRD) marker compared to WT1 gene overexpression by being specific to the malignant clone, although experimental evidence...... published so far includes very limited numbers of relapsed cases. Also, the stability of the NPM1 mutation has been questioned by reports of the mutation being lost at relapse. In the present study we compared NPM1 mutation and WT1 overexpression as MRD markers in 20 cases of relapsed AML. The 20 patients...... experienced a total of 28 morphological relapses. Karyotypic evolution was detected in 56% of relapses. All relapses were accompanied by high levels of NPM1 mutation, along with high WT1 mRNA levels, thus demonstrating complete stability of both markers during relapse. Detectable NPM1 mutation following...

  7. A fast algorithm for determining the linear complexity of a binary sequence with period 2npm

    Institute of Scientific and Technical Information of China (English)

    魏仕民; 肖国镇; 陈钟

    2001-01-01

    An efficient algorithm for determining the linear complexity and the minimal polynomial of a binary sequence with period 2npm is proposed and proved, where 2 is a primitive root modulo p2. The new algorithm generalizes the algorithm for computing the linear complexity of a binary sequence with period 2 n and the algorithm for computing the linear complexity of a binary sequence with period pn,where 2 is a primitive root modulo p2.

  8. Integrated Quality Management System in Public Urban Traffic

    Directory of Open Access Journals (Sweden)

    Husein Pašagić

    2005-09-01

    Full Text Available Public urban traffic (PUT requirements are based on thespecific characteristics that dictate the requirements themselves.The problems faced by all the big cities regarding public urbantransport are very similar, and they range from unacceptabilityof the very organisational structure of the system facing the populationgrowth, limitations and congestions of the traffic routesloaded by an increasing number of automobiles, to the chroniclack of economic funds for the investments that would createthe necessary conditions for positive shifts. In PUT there aremany random parameters whose statistical laws are not easy todetermine and it is often the topic of research of various profilesof scientists. There is always the satisfaction, that is, the lack ofsatisfaction by the final user of the public urban transport andall the other involved groups. The result is that the potential usersof public urban transport give up and try to find other solutionsfor their transport needs, turning in principle to individualtraffic. Consequently, the number of passenger cars on the trafficroutes increases along with all the resulting negative effects.The complex systems of public urban transport facing the increasingrequirements to improve efficiency have to be subjectedto certain changes in order to achieve physical sustainability oftraffic at all, and to satisfy the environmental requirements thatoccur as counterbalance to the pollution of the urban area.With the aim of achieving optimal conditions for the qualityof service, and by introducing acceptable traffic solutionscombined with the integrated quality management systembased on the standards ISO 9001 and ISO 14000 high-qualityshifts are made possible. The integration of these standards resultsin the rational combining of the quality management systeminto a single efficient system, reflected in achieving high-quality traffic and transport service, improved informationflow, unique documentation, positive

  9. The potent oncogene NPM-ALK mediates malignant transformation of normal human CD4(+) T lymphocytes.

    Science.gov (United States)

    Zhang, Qian; Wei, Fang; Wang, Hong Yi; Liu, Xiaobin; Roy, Darshan; Xiong, Qun-Bin; Jiang, Shuguang; Medvec, Andrew; Danet-Desnoyers, Gwenn; Watt, Christopher; Tomczak, Ewa; Kalos, Michael; Riley, James L; Wasik, Mariusz A

    2013-12-01

    With this study we have demonstrated that in vitro transduction of normal human CD4(+) T lymphocytes with NPM-ALK results in their malignant transformation. The transformed cells become immortalized and display morphology and immunophenotype characteristic of patient-derived anaplastic large-cell lymphomas. These unique features, which are strictly dependent on NPM-ALK activity and expression, include perpetual cell growth, proliferation, and survival; activation of the key signal transduction pathways STAT3 and mTORC1; and expression of CD30 (the hallmark of anaplastic large-cell lymphoma) and of immunosuppressive cytokine IL-10 and cell-surface protein PD-L1/CD274. Implantation of NPM-ALK-transformed CD4(+) T lymphocytes into immunodeficient mice resulted in formation of tumors indistinguishable from patients' anaplastic large-cell lymphomas. Our findings demonstrate that the key aspects of human carcinogenesis closely recapitulating the features of the native tumors can be faithfully reproduced in vitro when an appropriate oncogene is used to transform its natural target cells; this in turn points to the fundamental role in malignant cell transformation of potent oncogenes expressed in the relevant target cells. Such transformed cells should permit study of the early stages of carcinogenesis, and in particular the initial oncogene-host cell interactions. This experimental design could also be useful for studies of the effects of early therapeutic intervention and likely also the mechanisms of malignant progression.

  10. Public management in Serbia: From imitation to status quo

    Directory of Open Access Journals (Sweden)

    Janićijević Nebojša

    2011-01-01

    Full Text Available Public management in Serbia has been experiencing reform changes since 2000. In this paper we attempt to analyze reforms in public management in Serbia during the period 2000-2010 from two theoretical frameworks: the institutional changes perspective and the downsizing perspective. We believe that the selected time frame is suitable for our research, since the period of ten years is long enough for radical changes to take place. The analysis from the institutional changes perspective suggests that the success in creating the new state administration institutional model in Serbia will greatly depend on the amount of pressure put by the European Union and IMF on the Serbian Government, but also on raising the level of knowledge and competence for conducting necessary changes in the Serbian state administration. The analysis from the downsizing perspective reveals that efforts aimed at downsizing of public administration in Serbia, initiated by the need to achieve results quickly, have almost been blocked by strong forces towards maintaining the status quo.

  11. Governance in managing public health resources in Brazilian municipalities.

    Science.gov (United States)

    Avelino, George; Barberia, Lorena G; Biderman, Ciro

    2014-09-01

    This study contributes to the health governance discussion by presenting a new data set that allows for comparisons of the management of health resources among Brazilian municipalities. Research on Brazil is particularly important as the provision of health services was decentralized in 1988 and since then municipalities have been given greater responsibilities for the management of fiscal resources for public health service provision. Based on detailed information on corruption practices (such as over-invoicing, illegal procurement and fake receipts) from audit reports of health programmes in 980 randomly selected Brazilian municipalities, this study deepens understanding of the relationship between health governance institutions and the incidence of corruption at the local level by exploring the extent to which horizontal and vertical accountabilities contribute to reducing the propensity of municipal government officials to divert public health resources for private gain. The results of our multiple regression analysis suggest that the experience of health municipal councils is correlated with reductions in the incidence of corruption in public health programmes. This impact is significant over time, with each additional year of health council experience reducing corruption incidence levels by 2.1% from baseline values. The findings reported in this study do not rely on the subjectivity of corruption measures which usually conflate the actual incidence of corruption with its perception by informants. Based on our results, we provide recommendations that can assist policy makers to reduce corruption.

  12. Dynamic conformations of nucleophosmin (NPM1 at a key monomer-monomer interface affect oligomer stability and interactions with granzyme B.

    Directory of Open Access Journals (Sweden)

    Wei D Duan-Porter

    Full Text Available Nucleophosmin (NPM1 is an abundant, nucleolar tumor antigen with important roles in cell proliferation and putative contributions to oncogenesis. Wild-type NPM1 forms pentameric oligomers through interactions at the amino-terminal core domain. A truncated form of NPM1 found in some hepatocellular carcinoma tissue formed an unusually stable oligomer and showed increased susceptibility to cleavage by granzyme B. Initiation of translation at the seventh methionine generated a protein (M7-NPM that shared all these properties. We used deuterium exchange mass spectrometry (DXMS to perform a detailed structural analysis of wild-type NPM1 and M7-NPM, and found dynamic conformational shifts or local "unfolding" at a specific monomer-monomer interface which included the β-hairpin "latch." We tested the importance of interactions at the β-hairpin "latch" by replacing a conserved tyrosine in the middle of the β-hairpin loop with glutamic acid, generating Y67E-NPM. Y67E-NPM did not form stable oligomers and further, prevented wild-type NPM1 oligomerization in a dominant-negative fashion, supporting the critical role of the β-hairpin "latch" in monomer-monomer interactions. Also, we show preferential cleavage by granzyme B at one of two available aspartates (either D161 or D122 in M7-NPM and Y67E-NPM, whereas wild-type NPM1 was cleaved at both sites. Thus, we observed a correlation between the propensity to form oligomers and granzyme B cleavage site selection in nucleophosmin proteins, suggesting that a small change at an important monomer-monomer interface can affect conformational shifts and impact protein-protein interactions.

  13. Earning management: analysis of publications in brazilian accounting journals

    Directory of Open Access Journals (Sweden)

    Débora Gomes Machado

    2014-06-01

    Full Text Available The goal of this study is to identify characteristics, from the perspective of social networks, of the scientific literature on earning management in Brazilian accounting journals. Specifically, were identified: a authors and their social networks of scientific production; b researched topics, models for accruals detection, authors’ networks and the period studied; c methodological procedures used. A bibliometric survey, with a quantitative approach was performed through the analysis of 17 Brazilian accounting journals, since their first edition until the year 2010. Out of them, 10 published articles having the theme earning management in the title, abstract or keywords. The 32 identified articles were submitted to content analysis and then the data were presented from the perspective of social networks. The survey results show that: the authors and their social networks of production originates mostly from Universidade de São Paulo (USP; the most researched theme was the methods or means to conduct earnings management, and accruals measurement models, with emphasis on Kang and Sivaramakrishnan Model; the descriptive research, based on document and quantitative approach were the most commonly used forms in the articles researched. It is noteworthy that structural gaps are the topics, such as compensation plans, political costs and earnings management in different contractual environments. The research results can contribute to academia to highlight some features of the earnings management theme and its researchers, in the field of publications in Brazilian accounting journals.

  14. Strategic inventory management: An example of a public hospital

    Directory of Open Access Journals (Sweden)

    Murat Türk

    2011-02-01

    Full Text Available Businesses have to develop and implement effective stock policies to maximize profits by minimizing costs in today's market conditions. Since the stocks enterprises between 20% to 60% within total assets of manufacturing, effective implementation of stock control and management policies, has great importance for the future of business. Businesses’ execution of it’s stock policies at the lowest cost depends on the forecasting amount of stock based on demand at least error, and minimum stock level determination and the appropriate time and amount of orders given to it. Thus, time and cost savings will be achieved by ensuring balance of continuity and speed in production of goods and services in the production process.By the rapid changes in consumer preferences, the variety of products, technologies and competitors are rapidly changing and increasing in rate. By increases in product variety, stock control and management is becoming even more difficult and complex. In recent years, effective and efficient resource use and management began to be kept in the foreground in public institutions as well as private sector. Public hospitals have been diverged from other business such as restaurant and hotel since it is an inpatient treatment business. It’s obligation of keeping right supplies in right amount, in the right place at the right time and cost is stricter comparing other institutions.

  15. Strategic inventory management: an example of a public hospital

    Directory of Open Access Journals (Sweden)

    Murat Türk

    2011-02-01

    Full Text Available Businesses have to develop and implement effective stock policies to maximize profits by minimizing costs in today's market conditions. Since the stocks enterprises between 20% to 60% within total assets of manufacturings,  effective implementation of stock control and management policies, has great importance for the future of business.Businesses’ execution of it’s stock policies at the lowest cost depends on the forecasting amount of stock based on demand at least error, and minimum stock level determination and the appropriate time and amount of orders given to it. Thus, time and cost savings will be achieved by ensuring balance of continuity and speed in production of goods and services in the production process.By the rapid changes in consumer preferences, the variety of products, technologies and competitors are rapidly changing and increasing in rate. By increases in product variety, stock control and management is becoming even more difficult and complex.In recent years, effective and efficient resource use and management began to be kept in the foreground in public institutions as well as private sector. Public hospitals have been diverged from other business such as restaurant and hotel since it  is an inpatient treatment business.It’s obligation of keeping right supplies in right amount, in the right place at the right time and cost is more strict comparing other institutions.

  16. Public health financial management needs: report of a national survey.

    Science.gov (United States)

    Costich, Julia F; Honoré, Peggy A; Scutchfield, F Douglas

    2009-01-01

    The work reported here builds on the identification of public health financial management practice competencies by a national expert panel. The next logical step was to provide a validity check for the competencies and identify priority areas for educational programming. We developed a survey for local public health finance officers based on the public health finance competencies and field tested it with a convenience sample of officials. We asked respondents to indicate the importance of each competency area and the need for training to improve performance; we also requested information regarding respondent education, jurisdiction size, and additional comments. Our local agency survey sample drew on the respondent list from the National Association of County and City Health Officials 2005 local health department survey, stratified by agency size and limited to jurisdiction populations of 25,000 to 1,000,000. Identifying appropriate respondents was a major challenge. The survey was fielded electronically, yielding 112 responses from 30 states. The areas identified as most important and needing most additional training were knowledge of budget activities, financial data interpretation and communication, and ability to assess and correct the organization's financial status. The majority of respondents had some postbaccalaureate education. Many provided additional comments and recommendations. Health department finance officers demonstrated a high level of general agreement regarding the importance of finance competencies in public health and the need for training. The findings point to a critical need for additional training opportunities that are accessible, cost-effective, and targeted to individual needs.

  17. Medical ethics and new public management in Sweden.

    Science.gov (United States)

    Hansson, Sven Ove

    2014-07-01

    In order to shorten queues to healthcare, the Swedish government has introduced a yearly "queue billion" that is paid out to the county councils in proportion to how successful they are in reducing queues. However, only the queues for first visits are covered. Evidence has accumulated that queues for return visits have become longer. This affects the chronically and severely ill. Swedish physicians, and the Swedish Medical Association, have strongly criticized the queue billion and have claimed that it conflicts with medical ethics. Instead they demand that their professional judgments on priority setting and medical urgency be respected. This discussion provides an interesting illustration of some of the limitations of new public management and also more generally of the complicated relationships between medical ethics and public policy.

  18. Public Participation and Environmental management in Mountain National Parks

    Directory of Open Access Journals (Sweden)

    Stéphane Héritier

    2010-05-01

    Full Text Available Public involvement has become a key concept in conservation management worldwide. This paper provides an overview of the situation in four countries where national parks have been established for over a century, and where their creation often involved clearing the land of earlier indigenous settlements. Since the 1970s, public participation has become common practice in park management, even though such participation has taken on a variety of forms. The paper analyses the general trends in public participation in park management practices, participation that most authors consider has contributed to successful governance policies and helped build participative democracy. Analyses at different levels, however, reveal that public participation can also divide stakeholders, making it really difficult for any effective coalition of stakeholders to emerge.L’implication du public est devenue l’un des éléments clé des politiques de conservation dans le monde. Cet article a pour objectif de proposer une analyse générale dans quatre pays ayant établi des parcs nationaux de manière très précoce, souvent en opposition avec les populations locales ou autochtones. Depuis les années 1970, la participation publique est devenue une pratique commune dans la gestion des parcs nationaux, même si elle revêt des réalités très variables. Cet article analyse les tendances générales de la participation (notamment au niveau des dispositifs dans les pratiques de gestion des parcs nationaux, qui sont généralement considérées comme des réussites en termes de pratiques politiques ou de gouvernance et qui sont souvent présentées comme des modes d’élaboration de démocratie délibérative. L’analyse utilisant les différents niveaux scalaires tend à montrer au contraire que les dispositifs de participation publique peuvent aussi fragmenter les parties prenantes et rendre plus difficile la constitution efficace d’une coalition d’acteurs.

  19. Developments in public sector financial management in Estonia

    Directory of Open Access Journals (Sweden)

    Arno Almann

    2011-04-01

    Full Text Available Systems approach, contingency theory, modeling and interviewing are used to research whether the integration of the financial accounting and budget systems that are based on different accounting principles into a balanced overall system will increase the efficiency of financial management and will provide more ways of management in Estonian public organizations. The integration of the systems will create a semantically and organizationally interacting information system for a midterm period, which could be used at all managerial levels in all organizations in real time by developing the information technological infrastructure in Estonia. As feedback, control authorities impart information about the deviations between the objectives of the information and the attainments to the decision-makers, which will enable the decision-makers to make corrections and improve the quality of decisions.

  20. Solid waste management. Public power and monopoly or private market?

    Energy Technology Data Exchange (ETDEWEB)

    Basse, E.M. [Aarhus Univ., The Dept. Law, Aarhus (Denmark)

    1994-11-01

    In the article it is described that there is a growing recognition all over the World that environmental policies and regulation - especially regarding waste-should place far more emphasis on pollution prevention as a cross cutting strategy for reducing environmental risks and that long-term solutions in the waste management area are necessary. It is stated that the waste treatment policy on its way to establishing `sustainable development` must employ a rich mix of regulatory strategies involving use of new principles and new means. It is underlined in the article that many companies (also the publicly owned ones) have realized that it makes economic sense to avoid waste and that waste treatment services could be - and in some cases already are - good profitable business. In the future it is possible that there will be more of a bottom-up approach to the over-riding environmental policy goal of ensuring sustainable development by a more reasonable waste management strategy. (EG)

  1. Oncogenic tyrosine kinase NPM/ALK induces activation of the rapamycin-sensitive mTOR signaling pathway.

    Science.gov (United States)

    Marzec, M; Kasprzycka, M; Liu, X; El-Salem, M; Halasa, K; Raghunath, P N; Bucki, R; Wlodarski, P; Wasik, M A

    2007-08-16

    The mechanisms of cell transformation mediated by the nucleophosmin (NPM)/anaplastic lymphoma kinase (ALK) tyrosine kinase are only partially understood. Here, we report that cell lines and native tissues derived from the NPM/ALK-expressing T-cell lymphoma display persistent activation of mammalian target of rapamycin (mTOR) as determined by phosphorylation of mTOR targets S6rp and 4E-binding protein 1 (4E-BP1). The mTOR activation is serum growth factor-independent but nutrient-dependent. It is also dependent on the expression and enzymatic activity of NPM/ALK as demonstrated by cell transfection with wild-type and functionally deficient NPM/ALK, small interfering RNA (siRNA)-mediated NPM/ALK depletion and kinase activity suppression using the inhibitor WHI-P154. The NPM/ALK-induced mTOR activation is transduced through the mitogen-induced extracellular kinase (MEK)/extracellular signal-regulated kinase (ERK) signaling pathway and, to a much lesser degree, through the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) pathway. Accordingly, whereas the low-dose PI3K inhibitor wortmannin and Akt inhibitor III profoundly inhibited Akt phosphorylation, they had a very modest effect on S6rp and 4E-BP1 phosphorylation. In turn, MEK inhibitors U0126 and PD98059 and siRNA-mediated depletion of either ERK1 or ERK2 inhibited S6rp phosphorylation much more effectively. Finally, the mTOR inhibitor rapamycin markedly decreased proliferation and increased the apoptotic rate of ALK+TCL cells. These findings identify mTOR as a novel key target of NPM/ALK and suggest that mTOR inhibitors may prove effective in therapy of ALK-induced malignancies.

  2. Expression and significance of Wnt5a gene and NPM1 gene in chronic myeloid leukemia patients

    Institute of Scientific and Technical Information of China (English)

    Liang-Tuo Wang; Xiang-Lan Zhang; Jian-Yu Situ; Yuan-Ying Huang

    2015-01-01

    Objective:To detect Wnt5a gene expression and NPM1 gene in chronic myeloid leukemia bone marrow cells and to explore its relevance and significance.Methods:Sixty cases of chronic myeloid leukemia patients in our hospital were included in the experimental group, taking up 20 cases in the blastic phase, 20 cases in the accelerated phase, and 20 cases in the chronic phase; and 60 cases with benign hematologic disease were included in the control group. Cultured bone marrow cells were detected by RT-PCR methods to analyze the significance of Wnt5a and NPM1 gene expressions.Results:Wnt5a mRNA in the three sub-groups of the experimental group had low semi-quantitative mean values and positive rates compared with the control group. NPM1 mRNA positive rates and median expression levels were higher, and the difference was statistically significant. In the three subgroups of the experimental group, Wnt5a mRNA semi-quantitative mean values and positive rates in the blastic phase and accelerated phase were low, while NPM1 mRNA positive rates and median expression levels were higher; and the difference was statistically significant. Wnt5a and NPM1 expression levels in patients' white blood cell count were associated with bone marrow blast cells; and the difference was statistically significant. However, this was not associated with age, hemoglobin content and platelet count; and the difference was not statistically significant.Conclusion: There is a certain degree of correlation between Wnt5a and NPM1 genes and the occurrence and development of chronic myeloid leukemia. Wnt5a gene may inhibit its occurrence, while NPM1 gene positivity promotes its progression, which may be applied in the diagnosis and treatment of chronic myeloid leukemia, providing a new way of analyzing prognosis and a theoretical basis for clinical application.

  3. Green supply chain management: analysis of brazilian academic publications

    Directory of Open Access Journals (Sweden)

    José Carlos Barbieri

    2014-08-01

    Full Text Available This paper deals with environmental issues from the perspective of Supply Chain Management. With the incorporation of environmental concerns in a systematic manner the concept of Green Supply Chain Management (GSCM has emerged. The subject GSCM interests not only to academics but also to professional audience especially with regard to new legal obligations, and social pressures of various types of stakeholders, as well as issues related to the competitiveness of enterprises and their supply chains. However, the way in which this knowledge is being produced in Brazil is not clear, hence the need for a mapping which areas and sub-areas of GSCM has been studied most frequently. Thus, this work can be characterized as a desk research that aims to analyze the Brazilian academic publications on green supply chain management. In order to delimit the scope of the research, we collected articles published from 2006 to 2010 in specific Brazilian congresses of Management and Production Engineering, as EnANPAD, SIMPOI and SIMPEP. 110 papers were collected and analyzed.The area of Green Operations represents 81% of published articles and 45% of these focus on Reverse Logistics. 70% of total papers are empirical and 77% use a qualitative approach, while 57% of the total are case studies

  4. 76 FR 10050 - Changes to the Public Housing Assessment System (PHAS): Management Operations Scoring Notice

    Science.gov (United States)

    2011-02-23

    ... URBAN DEVELOPMENT Changes to the Public Housing Assessment System (PHAS): Management Operations Scoring... of the public about HUD's process for issuing scores under the management operations indicator of the... process for the PHAS management operations indicator. The purpose of the management operations...

  5. 78 FR 64199 - Fisheries of the South Atlantic; South Atlantic Fishery Management Council; Public Meeting

    Science.gov (United States)

    2013-10-28

    .... SUMMARY: The South Atlantic Fishery Management Council's (Council) Scientific and Statistical Committee... Atlantic Fishery Management Council; Public Meeting AGENCY: National Marine Fisheries Service (NMFS...: (800) 445-8667 or (843) 308- 9330. Council address: South Atlantic Fishery Management Council,...

  6. 78 FR 48653 - Fisheries of the South Atlantic; South Atlantic Fishery Management Council; Public Meeting

    Science.gov (United States)

    2013-08-09

    ... Fishery Management Council (SAFMC) Scientific and Statistical Committee (SSC). SUMMARY: The SAFMC will... Atlantic Fishery Management Council; Public Meeting AGENCY: National Marine Fisheries Service (NMFS...: South Atlantic Fishery Management Council, 4055 Faber Place Drive, Suite 201, N. Charleston, SC...

  7. Understanding human resource management practices in Botswana's public health sector.

    Science.gov (United States)

    Seitio-Kgokgwe, Onalenna Stannie; Gauld, Robin; Hill, Philip C; Barnett, Pauline

    2016-11-21

    Purpose The purpose of this paper is to assess the management of the public sector health workforce in Botswana. Using institutional frameworks it aims to document and analyse human resource management (HRM) practices, and make recommendations to improve employee and health system outcomes. Design/methodology/approach The paper draws from a large study that used a mixed methods approach to assess performance of Botswana's Ministry of Health (MOH). It uses data collected through document analysis and in-depth interviews of 54 key informants comprising policy makers, senior staff of the MOH and its stakeholder organizations. Findings Public health sector HRM in Botswana has experienced inadequate planning, poor deployment and underutilization of staff. Lack of comprehensive retention strategies and poor working conditions contributed to the failure to attract and retain skilled personnel. Relationships with both formal and informal environments affected HRM performance. Research limitations/implications While document review was a major source of data for this paper, the weaknesses in the human resource information system limited availability of data. Practical implications This paper presents an argument for the need for consideration of formal and informal environments in developing effective HRM strategies. Originality/value This research provides a rare system-wide approach to health HRM in a Sub-Saharan African country. It contributes to the literature and evidence needed to guide HRM policy decisions and practices.

  8. IFRS ADOPTION AND EARNINGS MANAGEMENT IN BRAZILIAN PUBLICLY TRADED COMPANIES

    Directory of Open Access Journals (Sweden)

    Roberto Midoguti Joia

    2014-03-01

    Full Text Available In 2007, Brazil adopted the International Financial Reporting Standards (IFRS. Studies involving publicly traded companies in different countries around the world indicate that these new standards tend to improve the information quality and make it more comparable and transparent. This study was aimed at verifying any changes in the earnings management levels after 2010 and whether this happened in function of the full adoption of the IFRS by the Brazilian publicly traded companies (except for financial institutions. The data were extracted from the three-monthly financial statements of the databases from Economática and the Brazilian Securities Commission for the period from 2006 till 2011. To achieve the research objectives, two tests were applied. The first showed that the average discretionary accruals, calculated through the Modified Jones Model, were lower after 2010. Next, the regression analysis was elaborated, using panel data with Newey-West’s correction. The results did not confirm the hypothesis that the adoption of the IFRS affected the earnings management level in the period under analysis, but showed that the size and indebtedness significantly explain the discretionary accruals, independently of the adoption of the IFRS. The results suggest that larger companies with a large proportion of own capital tend to produce higher quality reports, independently of the adoption of the IFRS.

  9. Public private partnerships in solid waste management – case study

    Directory of Open Access Journals (Sweden)

    Christine Parmezani Munhoz

    2016-02-01

    Full Text Available This paper analyzes two public notices for PPP (Public-Private Partnerships - Law 11.079/2004 for solid waste management and verifies the suitability of these contracts to the new guidelines of Law 12.305/2010 - National Solid Waste Policy - PNRS. The online versions of 2 public notices and draft PPP Contracts, recently signed in the city of São Carlos and the Metropolitan Area of Belo Horizonte and Colar Metropolitano were analyzed. The mapping of the performance indicators of these documents was carried out according to 4 criteria: (a minimization of waste in landfills, (b recovery and valorization of solid waste (recycling, composting, etc.; (c pickers inclusion; and (d social participation. The results indicate that the analyzed contracts meet only part of the guidelines set by PNRS, mainly the eradication of the dumps and the final disposal of waste in landfills. The main object of these contracts remains linked to the old paradigm of waste management: collection and transportation of waste and operation of landfills. To meet the waste minimization policies, there are financial incentives that reward the reduction in the final disposal in landfills. However, there are no fixed contractual targets for the minimization of waste at landfills. If waste minimization policies, like reverse logistics and responsibility shared are implemented by the government, the contracts have clauses allowing periodic reviews for gradual adjustments, ensuring the economic and financial balance of the contract. It is yet to determine the efficiency of these mechanisms to meet the guidelines of PNRS, in the curse of the concession.

  10. Oncogenic kinase NPM/ALK induces through STAT3 expression of immunosuppressive protein CD274 (PD-L1, B7-H1).

    Science.gov (United States)

    Marzec, Michal; Zhang, Qian; Goradia, Ami; Raghunath, Puthiyaveettil N; Liu, Xiaobin; Paessler, Michele; Wang, Hong Yi; Wysocka, Maria; Cheng, Mangeng; Ruggeri, Bruce A; Wasik, Mariusz A

    2008-12-30

    The mechanisms of malignant cell transformation caused by the oncogenic, chimeric nucleophosmin (NPM)/anaplastic lymphoma kinase (ALK) remain only partially understood, with most of the previous studies focusing mainly on the impact of NPM/ALK on cell survival and proliferation. Here we report that the NPM/ALK-carrying T cell lymphoma (ALK+TCL) cells strongly express the immunosuppressive cell-surface protein CD274 (PD-L1, B7-H1), as determined on the mRNA and protein level. The CD274 expression is strictly dependent on the expression and enzymatic activity of NPM/ALK, as demonstrated by inhibition of the NPM/ALK function in ALK+TCL cells by the small molecule ALK inhibitor CEP-14083 and by documenting CD274 expression in IL-3-depleted BaF3 cells transfected with the wild-type NPM/ALK, but not the kinase-inactive NPM/ALK K210R mutant or empty vector alone. NPM/ALK induces CD274 expression by activating its key signal transmitter, transcription factor STAT3. STAT3 binds to the CD274 gene promoter in vitro and in vivo, as shown in the gel electromobility shift and chromatin immunoprecipitation assays, and is required for the PD-L1 gene expression, as demonstrated by siRNA-mediated STAT3 depletion. These findings identify an additional cell-transforming property of NPM/ALK and describe a direct link between an oncoprotein and an immunosuppressive cell-surface protein. These results also provide an additional rationale to therapeutically target NPM/ALK and STAT3 in ALK+TCL. Finally, they suggest that future immunotherapeutic protocols for this type of lymphoma may need to include the inhibition of NPM/ALK and STAT3 to achieve optimal clinical efficacy.

  11. Reactive oxygen species and lipoxygenases regulate the oncogenicity of NPM-ALK-positive anaplastic large cell lymphomas.

    Science.gov (United States)

    Thornber, K; Colomba, A; Ceccato, L; Delsol, G; Payrastre, B; Gaits-Iacovoni, F

    2009-07-23

    The chimera nucleophosmin-anaplastic lymphoma kinase (NPM-ALK), the tyrosine kinase activity of which is constitutively upregulated, is the causative agent of 75% of the anaplastic large-cell lymphomas (ALCLs). We have demonstrated that NPM-ALK induces the production of reactive oxygen species (ROS) by a pathway involving the arachidonic acid-metabolizing enzymes of the lipoxygenase (LOX) family. The use of the LOX inhibitor nordihydroguaiaretic acid (NDGA) and of the anti-oxidant N-acetylcysteine (NAC) demonstrated that ROS are important in maintaining the ALK kinase active. Consistent with this, NDGA treatment resulted in the inhibition of key pathways, such as Akt, signal transducer and activator of transcription factor 3 (STAT3) and extracellular signal-regulated kinase (ERK), which are involved in NPM-ALK antiapoptotic and pro-mitogenic functions. Conversely, the stress-activated kinase p38, described in some instances as a mediator of apoptosis, was activated. Interestingly, 5-LOX, an isoform involved in many cancers, was found to be activated in NPM-ALK(+) cells. Functional studies have shown that transforming properties, namely proliferation and resistance to apoptosis, were abrogated by treatment with either NDGA or the 5-LOX inhibitor (N-(3-phenoxycinnamyl)-acetohydroxamic acid) (BW A4C). Together, these data point to the ROS/LOX pathway as a potential new target for therapy in NPM-ALK-positive tumors.

  12. Polo-like kinase 2-dependent phosphorylation of NPM/B23 on serine 4 triggers centriole duplication.

    Science.gov (United States)

    Krause, Annekatrin; Hoffmann, Ingrid

    2010-03-24

    Duplication of the centrosome is well controlled during faithful cell division while deregulation of this process leads to supernumary centrosomes, chromosome missegregation and aneuploidy, a hallmark of many cancer cells. We previously reported that Polo-like kinase 2 (Plk2) is activated near the G1/S phase transition, and regulates the reproduction of centrosomes. In search for Plk2 interacting proteins we have identified NPM/B23 (Nucleophosmin) as a novel Plk2 binding partner. We find that Plk2 and NPM/B23 interact in vitro in a Polo-box dependent manner. An association between both proteins was also observed in vivo. Moreover, we show that Plk2 phosphorylates NPM/B23 on serine 4 in vivo in S-phase. Notably, expression of a non-phosphorylatable NPM/B23 S4A mutant interferes with centriole reduplication in S-phase arrested cells and leads to a dilution of centriole numbers in unperturbed U2OS cells. The corresponding phospho-mimicking mutants have the opposite effect and their expression leads to the accumulation of centrioles. These findings suggest that NPM/B23 is a direct target of Plk2 in the regulation of centriole duplication and that phosphorylation on serine 4 can trigger this process.

  13. The NPM-ALK tyrosine kinase mimics TCR signalling pathways, inducing NFAT and AP-1 by RAS-dependent mechanisms.

    Science.gov (United States)

    Turner, Suzanne D; Yeung, Debra; Hadfield, Kathryn; Cook, Simon J; Alexander, Denis R

    2007-04-01

    Nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) expression is associated with the lymphoid malignancy anaplastic large cell lymphoma (ALCL) and results from a t(2;5) chromosomal translocation. We show that NPM-ALK induces Ras activation and phosphorylation of the ERK MAP Kinase consistent with activation of the Ras-MAP Kinase pathway. Furthermore, we demonstrate that activation of Ras is necessary for inducing transcription via NFAT/AP-1 composite transcriptional binding sites. This activity is dependent on NPM-ALK forming complexes with proteins that bind to autophosphorylated tyrosine residues at positions 156, 567 and 664, associated with binding to IRS-1, Shc and PLCgamma, respectively. Specifically, NPM-ALK activates transcription from the TRE promoter element, an AP-1 binding region, an activity dependent on both Ras and Shc activity. Our results show that NPM-ALK mimics activated T-cell receptor signalling by inducing pathways associated with the activation of NFAT/AP-1 transcription factors that bind to promoter elements found in a broad array of cytokine genes.

  14. NPM-ALK oncogenic tyrosine kinase controls T-cell identity by transcriptional regulation and epigenetic silencing in lymphoma cells.

    Science.gov (United States)

    Ambrogio, Chiara; Martinengo, Cinzia; Voena, Claudia; Tondat, Fabrizio; Riera, Ludovica; di Celle, Paola Francia; Inghirami, Giorgio; Chiarle, Roberto

    2009-11-15

    Transformed cells in lymphomas usually maintain the phenotype of the postulated normal lymphocyte from which they arise. By contrast, anaplastic large cell lymphoma (ALCL) is a T-cell lymphoma with aberrant phenotype because of the defective expression of the T-cell receptor and other T-cell-specific molecules for still undetermined mechanisms. The majority of ALCL carries the translocation t(2;5) that encodes for the oncogenic tyrosine kinase NPM-ALK, fundamental for survival, proliferation, and migration of transformed T cells. Here, we show that loss of T-cell-specific molecules in ALCL cases is broader than reported previously and involves most T-cell receptor-related signaling molecules, including CD3epsilon, ZAP70, LAT, and SLP76. We further show that NPM-ALK, but not the kinase-dead NPM-ALK(K210R), downregulated the expression of these molecules by a STAT3-mediated gene transcription regulation and/or epigenetic silencing because this downregulation was reverted by treating ALCL cells with 5-aza-2-deoxycytidine or by knocking down STAT3 through short hairpin RNA. Finally, NPM-ALK increased the methylation of ZAP70 intron 1-exon 2 boundary region, and both NPM-ALK and STAT3 regulated the expression levels of DNA methyltransferase 1 in transformed T cells. Thus, our data reveal that oncogene-deregulated tyrosine kinase activity controls the expression of molecules that determine T-cell identity and signaling.

  15. Polo-like kinase 2-dependent phosphorylation of NPM/B23 on serine 4 triggers centriole duplication.

    Directory of Open Access Journals (Sweden)

    Annekatrin Krause

    Full Text Available Duplication of the centrosome is well controlled during faithful cell division while deregulation of this process leads to supernumary centrosomes, chromosome missegregation and aneuploidy, a hallmark of many cancer cells. We previously reported that Polo-like kinase 2 (Plk2 is activated near the G1/S phase transition, and regulates the reproduction of centrosomes. In search for Plk2 interacting proteins we have identified NPM/B23 (Nucleophosmin as a novel Plk2 binding partner. We find that Plk2 and NPM/B23 interact in vitro in a Polo-box dependent manner. An association between both proteins was also observed in vivo. Moreover, we show that Plk2 phosphorylates NPM/B23 on serine 4 in vivo in S-phase. Notably, expression of a non-phosphorylatable NPM/B23 S4A mutant interferes with centriole reduplication in S-phase arrested cells and leads to a dilution of centriole numbers in unperturbed U2OS cells. The corresponding phospho-mimicking mutants have the opposite effect and their expression leads to the accumulation of centrioles. These findings suggest that NPM/B23 is a direct target of Plk2 in the regulation of centriole duplication and that phosphorylation on serine 4 can trigger this process.

  16. NPM-RAR binding to TRADD selectively inhibits caspase activation, while allowing activation of NFκB and JNK.

    Science.gov (United States)

    Chattopadhyay, Anuja; Abecassis, Irina; Redner, Robert L

    2015-01-01

    The t(5;17) variant of acute promeylocytic leukemia (APL) expresses a fusion of nucleophosmin (NPM) with the retinoic acid receptor alpha (RARA). We have previously shown that NPM-RAR is a binding partner of the tumor necrosis factor (TNF) receptor type-I-associated DEATH domain protein, TRADD. Binding of TNF to its receptor, TNF-R, induces recruitment of TRADD, and subsequent recruitment of a cascade of proteins that ultimate activate caspase 3, nuclear factor κB (NFκB) and c-Jun N-terminal kinase (JNK). We have previously shown that NPM-RAR interaction with TRADD blocks TNF activation of caspase 3, caspase 8, poly(ADP-ribose) polymerase (PARP) cleavage and, ultimately, apoptosis. We now report that NPM-RAR expression is permissive for TNF activation of NFκB and JNK. We propose that inhibition of TNF activation of apoptosis, while preserving TNF activation of NFκB and JNK pathways that stimulate cell growth and survival, represents a novel mechanism through which NPM-RAR contributes to development of the leukemic phenotype.

  17. Recurrent mutations, including NPM1c, activate a BRD4-dependent core transcriptional program in acute myeloid leukemia.

    Science.gov (United States)

    Dawson, M A; Gudgin, E J; Horton, S J; Giotopoulos, G; Meduri, E; Robson, S; Cannizzaro, E; Osaki, H; Wiese, M; Putwain, S; Fong, C Y; Grove, C; Craig, J; Dittmann, A; Lugo, D; Jeffrey, P; Drewes, G; Lee, K; Bullinger, L; Prinjha, R K; Kouzarides, T; Vassiliou, G S; Huntly, B J P

    2014-02-01

    Recent evidence suggests that inhibition of bromodomain and extra-terminal (BET) epigenetic readers may have clinical utility against acute myeloid leukemia (AML). Here we validate this hypothesis, demonstrating the efficacy of the BET inhibitor I-BET151 across a variety of AML subtypes driven by disparate mutations. We demonstrate that a common 'core' transcriptional program, which is HOX gene independent, is downregulated in AML and underlies sensitivity to I-BET treatment. This program is enriched for genes that contain 'super-enhancers', recently described regulatory elements postulated to control key oncogenic driver genes. Moreover, our program can independently classify AML patients into distinct cytogenetic and molecular subgroups, suggesting that it contains biomarkers of sensitivity and response. We focus AML with mutations of the Nucleophosmin gene (NPM1) and show evidence to suggest that wild-type NPM1 has an inhibitory influence on BRD4 that is relieved upon NPM1c mutation and cytosplasmic dislocation. This leads to the upregulation of the core transcriptional program facilitating leukemia development. This program is abrogated by I-BET therapy and by nuclear restoration of NPM1. Finally, we demonstrate the efficacy of I-BET151 in a unique murine model and in primary patient samples of NPM1c AML. Taken together, our data support the use of BET inhibitors in clinical trials in AML.

  18. Sensitivity Analysis of the NPM-ALK Signalling Network Reveals Important Pathways for Anaplastic Large Cell Lymphoma Combination Therapy

    Science.gov (United States)

    Buetti-Dinh, Antoine; O’Hare, Thomas

    2016-01-01

    A large subset of anaplastic large cell lymphoma (ALCL) patients harbour a somatic aberration in which anaplastic lymphoma kinase (ALK) is fused to nucleophosmin (NPM) resulting in a constitutively active signalling fusion protein, NPM-ALK. We computationally simulated the signalling network which mediates pathological cell survival and proliferation through NPM-ALK to identify therapeutically targetable nodes through which it may be possible to regain control of the tumourigenic process. The simulations reveal the predominant role of the VAV1-CDC42 (cell division control protein 42) pathway in NPM-ALK-driven cellular proliferation and of the Ras / mitogen-activated ERK kinase (MEK) / extracellular signal-regulated kinase (ERK) cascade in controlling cell survival. Our results also highlight the importance of a group of interleukins together with the Janus kinase 3 (JAK3) / signal transducer and activator of transcription 3 (STAT3) signalling in the development of NPM-ALK derived ALCL. Depending on the activity of JAK3 and STAT3, the system may also be sensitive to activation of protein tyrosine phosphatase-1 (SHP1), which has an inhibitory effect on cell survival and proliferation. The identification of signalling pathways active in tumourigenic processes is of fundamental importance for effective therapies. The prediction of alternative pathways that circumvent classical therapeutic targets opens the way to preventive approaches for countering the emergence of cancer resistance. PMID:27669408

  19. Governance of the Public Debt Management Agency in Selected OECD Countries

    OpenAIRE

    Grezegorz Golebiowsku; Kamilla Marchewka-Bartkowiak

    2010-01-01

    In most countries public debt management is one of the fastest growing financial activities demanding great attention from the State. Therefore, there is a need for broadening public governance, as well as widening procedural solutions. The authors have analysed the operating principles of auditing and control in public debt management institutions of several OECD countries. Research was conducted based on questionnaires and reports obtained from selected public debt management institutions a...

  20. 急性髓系白血病NPM1基因突变检测的临床意义%Detection of NPM1 gene mutation in acute myeloid leukemia

    Institute of Scientific and Technical Information of China (English)

    马亮; 钟明华; 丰岱荣; 龙红; 沈军; 马一盖; 黄尚志

    2012-01-01

    目的 探讨初诊急性髓细胞白血病(acute myeloid leukemia,AML)患者NPM1基因突变发生率及其与染色体核型和FAB亚型之间的关系,并分析NPM1基因的突变类型.方法 选取2004至2010年中日友好医院血液科99例初诊AML患者.采集患者骨髓标本,采用聚合酶链反应(polymerase chain reaction,PCR)扩增基因组DNA,并采用变性聚丙烯酰胺凝胶电泳(polyacrylamide gel electrophoresis,PAGE)和毛细管电泳两种方法对AML患者NPM1基因突变进行检测.应用G显带方法对其中72例初诊AML患者进行细胞遗传学分析,同时对10例NPM1突变阳性患者进行直接测序分析.NPM1插入突变在各亚型患者中发生率的比较采用x2检验.变性PAGE和毛细管电泳两种方法检测NPM1基因突变发生率的比较采用McNemar检验.结果 毛细管电泳法与变性PAGE法检测AML患者NPM1基因插入突变发生率分别为15% (15/99)和11% (11/99),差异无统计学意义(x2 =2.25,P>0.05).NPM1插入突变在各亚型患者中发生率分别为:急性粒细胞白血病部分分化型(M2)(27%,8/30)、急性单核细胞白血病(M5)(32%,6/19)、红白血病(M6)(13%,1/8),差异无统计学意义(x2=1.06,P>0.05),其余亚型未检测到NPM1插入突变.49例AML异常核型患者的NPM1插入突变发生率为4% (2/49),23例正常核型患者的NPM1插入突变发生率为26% (6/23),差异有统计学意义(x2=5.61,P<0.05).10例NPM1基因插入突变均为A型突变(c.860_863 dupTCTG).突变导致NPM蛋白羧基末端读码框移,末尾7个氨基酸WQWRKSL被11个氨基酸CLAVEEVSLRK所代替.2例患者检测到内含子缺失突变,分别为IVS10-18_-15delCTTT和IVS10-17-15delTTT.结论 NPM1插入突变为AML患者常见基因改变,正常核型患者插入突变发生率高于异常核型患者.在NPM1基因内含子区发现2例缺失突变.%Objective To analyze the frequency of NPM1 mutation in de novo acute myeloid leukemia (AML) patients and the relationship

  1. Public management and pitizen participation in La Plata's city council

    Directory of Open Access Journals (Sweden)

    Beatriz Nelly Plot

    2005-01-01

    Full Text Available This proyect rises the dificlutties and challeges, that political power and society have faced because of the implimetation of the new technologies on territorial management, which started to be developed togerther with the State Reform of the nineties. This study is carried through the analysis of two basic tools by the State Modernization Plan and called upon to participate by the City Council: the Participative Budget and the Strategic Plan. The analysis of these experiences allows us to observe, on the one hand, to what extent political power yields power spaces to the citizenship with absolute conviction; and, on the other hand, the level of presence and commitment that the society undertakes when participating in these spaces open to all the actors who, with different interests, are involved in the construction of the city. Whit the outcome of both expiriences the opportunity to give rise to a deeper change in the city management and the prospects for dealing with the demands arisen from agreements reached by the community are missed. Finally, it is deemed necessary to build up a more persevering and firmer attitude on the part of the society which may allow it to reach participative levels in those sectors of management where public policies, which directly affect it, are both planned and executed.

  2. Integration of accounting principles for non-public and public management sectors

    Directory of Open Access Journals (Sweden)

    Tatyana Nikolayevna Kichenina

    2015-09-01

    Full Text Available Objective to identify and complement the principles of accounting in autonomous institutions for use in the development of organizational and methodological approaches to accounting in autonomous institutions. Methods this article uses a dialectical approach to study economic phenomena. Results analyzing the theoretical methodological and practical issues of the organization of the autonomous sports institutions under reforming of the public management sector the author substantiates the accounting principles that meet the objectives of the accounting activities of autonomous institutions proposes the principle of using the unified methodological tools for the integration of accounting in nonpublic and public management sectors. Scientific novelty currently there is a need to create an accounting system that would meet the requirements of forming the objective and reliable information on the activities of institutions in accordance with the socioeconomic tasks for which they are created. To ensure the principles of independence in the commercial activity and control over the targeted and efficient use of budgetary funds the author systematized and supplemented the accounting principles of autonomous institutions. Practical significance conclusions and proposals resulting from the study may be used in the practice of autonomous institutions in different sectors. nbsp

  3. New Public Management in Korean Higher Education: Is It Reality or Another Fad?

    Science.gov (United States)

    Byun, Kiyong

    2008-01-01

    The purpose of this study is to analyze changing patterns of governance in Korean higher education through the window of the NPM, so as to compare policy developments in Korea to wider international trends. Building upon Braun & Merrien (1999)'s earlier analytical framework on university governance, the study focuses on the following dimensions in…

  4. Effect of NPM1 Mutations on the Invasion Potential of Leukemic Cells in vitro%NPM1基因突变对急性白血病细胞系体外侵袭能力的影响

    Institute of Scientific and Technical Information of China (English)

    邵会媛; 苗宗玉; 覃凤娴; 陈先春; 谭诗; 高玉洁; 张伶

    2010-01-01

    核仁磷酸蛋白基因(nucleophosmin,NPM1)突变是目前急性髓系白血病发生突变率最高的基因改变,与白血病的发生发展密切相关.为探讨NPM1突变对白血病细胞体外侵袭能力的影响,将载体pEGFPC1-NPM1-mA转染THP-1白血病细胞系,筛选稳定表达NPM A型突变蛋白(NPM1-mA)的白血病细胞株(THP-1-mA).通过transwell迁移实验、Matrigel侵袭实验以及细胞粘附实验来观察THP-1-mA细胞体外浸润转移能力的改变.结果发现,THP-1-mA细胞的体外迁移能力和侵袭能力明显高于亲代THP-1细胞;此外,THP-1-mA细胞对纤维连接蛋白的粘附能力也显著高于THP-1细胞.因此,我们的研究结果提示,NPM1突变可增强白血病细胞的体外侵袭能力,这有利于进一步明确NPMJ突变基因在白血病细胞恶性转化中的调控作用.

  5. The validity and utility of the positive presentation management and negative presentation management scales for the Revised NEO Personality Inventory.

    Science.gov (United States)

    Sellbom, Martin; Bagby, R Michael

    2008-06-01

    Schinka, Kinder, and Kremer developed "validity" scales for the Revised NEO Personality Inventory (NEO PI-R; Costa & McCrae) to detect underreporting-the Positive Presentation Management (PPM) Scale and overreporting-the Negative Presentation Management (NPM) Scale. In this investigation, the clinical utility of these scales was examined using the established validity scales from the Minnesota Multiphasic Personality Inventory-2 (MMPI-2; Butcher et al.) as the referent. The sample was composed of 370 psychiatric patients who completed the NEO PI-R and the MMPI-2 as part of a routine evaluation. Results indicated that response distortion compromised the utility of the NEO PI-R domain scales. Moreover, the PPM and NPM scales and an NPM-PPM index significantly differentiated invalid under-and overreporting groups from a valid responding group. The PPM and NPM-PPM index were adequate in classifying under- and overreporters, respectively.

  6. Traditional vs. Contemporary Management Control Practices for Developing Public Health Policies.

    Science.gov (United States)

    Naranjo-Gil, David; Sánchez-Expósito, María Jesús; Gómez-Ruiz, Laura

    2016-07-14

    Public health policies must address multiple goals and complex community health needs. Recently, management control practices have emerged to provide a broader type of information for evaluating the effectiveness of healthcare policies, and relate activities and processes to multiple strategic outcomes. This study compares the effect of traditional and contemporary management control practices on the achievement of public health policies. It is also analyzed how two different uses of such practices (enabling vs. coercive) facilitate the achievement of public health policies. Relationships are explored using data collected from managers from public health agencies and public hospitals in Spain. The findings show that contemporary management control practices are more suitable than traditional practices to achieve public health policies. Furthermore, results show that public health policies are better achieved when managers use management control practices in an enabling way rather than in a coercive way.

  7. Traditional vs. Contemporary Management Control Practices for Developing Public Health Policies

    Science.gov (United States)

    Naranjo-Gil, David; Sánchez-Expósito, María Jesús; Gómez-Ruiz, Laura

    2016-01-01

    Public health policies must address multiple goals and complex community health needs. Recently, management control practices have emerged to provide a broader type of information for evaluating the effectiveness of healthcare policies, and relate activities and processes to multiple strategic outcomes. This study compares the effect of traditional and contemporary management control practices on the achievement of public health policies. It is also analyzed how two different uses of such practices (enabling vs. coercive) facilitate the achievement of public health policies. Relationships are explored using data collected from managers from public health agencies and public hospitals in Spain. The findings show that contemporary management control practices are more suitable than traditional practices to achieve public health policies. Furthermore, results show that public health policies are better achieved when managers use management control practices in an enabling way rather than in a coercive way. PMID:27428985

  8. Activation of Rac1 and the exchange factor Vav3 are involved in NPM-ALK signaling in anaplastic large cell lymphomas.

    Science.gov (United States)

    Colomba, A; Courilleau, D; Ramel, D; Billadeau, D D; Espinos, E; Delsol, G; Payrastre, B; Gaits-Iacovoni, F

    2008-04-24

    The majority of anaplastic large cell lymphomas (ALCLs) express the nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) fusion protein, which is oncogenic due to its constitutive tyrosine kinase activity. Transformation by NPM-ALK not only increases proliferation, but also modifies cell shape and motility in both lymphoid and fibroblastic cells. We report that the Rac1 GTPase, a known cytoskeletal regulator, is activated by NPM-ALK in ALCL cell lines (Karpas 299 and Cost) and transfected cells (lymphoid Ba/F3 cells, NIH-3T3 fibroblasts). We have identified Vav3 as one of the exchange factors involved in Rac1 activation. Stimulation of Vav3 and Rac1 by NPM-ALK is under the control of Src kinases. It involves formation of a signaling complex between NPM-ALK, pp60(c-src), Lyn and Vav3, in which Vav3 associates with tyrosine 343 of NPM-ALK via its SH2 domain. Moreover, Vav3 is phosphorylated in NPM-ALK positive biopsies from patients suffering from ALCL, demonstrating the pathological relevance of this observation. The use of Vav3-specific shRNA and a dominant negative Rac1 mutant demonstrates the central role of GTPases in NPM-ALK elicited motility and invasion.

  9. The ALK inhibitor ASP3026 eradicates NPM-ALK⁺ T-cell anaplastic large-cell lymphoma in vitro and in a systemic xenograft lymphoma model.

    Science.gov (United States)

    George, Suraj Konnath; Vishwamitra, Deeksha; Manshouri, Roxsan; Shi, Ping; Amin, Hesham M

    2014-07-30

    NPM-ALK⁺ T-cell anaplastic large-cell lymphoma (ALCL) is an aggressive type of cancer. Standard treatment of NPM-ALK⁺ ALCL is CHOP polychemotherapy. Although patients initially respond favorably to CHOP, resistance, relapse, and death frequently occur. Recently, selective targeting of ALK has emerged as an alternative therapeutic strategy. ASP3026 is a second-generation ALK inhibitor that can overcome crizotinib resistance in non-small cell lung cancer, and is currently being evaluated in clinical trials of patients with ALK⁺ solid tumors. However, NPM-ALK⁺ ALCL patients are not included in these trials. We studied the effects of ASP3026 on NPM-ALK⁺ ALCL cell lines in vitro and on systemic lymphoma growth in vivo. ASP3026 decreased the viability, proliferation, and colony formation, as well as induced apoptotic cell death of NPM-ALK⁺ ALCL cells. In addition, ASP3026 significantly reduced the proliferation of 293T cells transfected with NPM-ALK mutants that are resistant to crizotinib and downregulated tyrosine phosphorylation of these mutants. Moreover, ASP3026 abrogated systemic NPM-ALK⁺ ALCL growth in mice. Importantly, the survival of ASP3026-treated mice was superior to that of control and CHOP-treated mice. Our data suggest that ASP3026 is an effective treatment for NPM-ALK⁺ ALCL, and support the enrollment of patients with this lymphoma in the ongoing clinical trials.

  10. Downregulation of NPM-ALK by siRNA causes anaplastic large cell lymphoma cell growth inhibition and augments the anti cancer effects of chemotherapy in vitro.

    Science.gov (United States)

    Hsu, Faye Yuan-yi; Zhao, Yi; Anderson, W French; Johnston, Patrick B

    2007-06-01

    The fusion protein, nucleophosmin-anaplastic lymphoma kinase (NPM-ALK), results from the chromosome translocation t(2;5)(p23;q25) and is present in 50-70 percent of anaplastic large-cell lymphomas (ALCLs). NPM-ALK is a constitutively activated kinase that transforms cells through stimulating several mitogenic signaling pathways. To examine if the NPM-ALK is a potential therapeutic target in ALCL, we used siRNA to specifically downregulate the expression of the NPM-ALK in ALCL cell lines. In this report, we demonstrated viability loss in t(2;5)-positive ALCL cell lines, SUDHL-1 and Karpas 299 cells, but not in lymphoma cell lines without the chromosome translocation, Jurkat and Granta 519 cells. Further study demonstrated that the downregulation of NPM-ALK resulted in decreased cell proliferation and increased cell apoptosis. When used in combination with chemotherapeutic agents, such as doxorubicin, the inhibition of the NPM-ALK augments the chemosensitivity of the tumor cells. These results revealed the importance of continuous expression of NPM-ALK in maintaining the growth of ALCL cells. Our data also suggested that the repression of the fusion gene might be a potential novel therapeutic strategy for NPM-ALK positive ALCLs.

  11. Detection of NPM1 exon 12 mutations and FLT3 – internal tandem duplications by high resolution melting analysis in normal karyotype acute myeloid leukemia

    Directory of Open Access Journals (Sweden)

    Carney Dennis A

    2008-07-01

    Full Text Available Abstract Background Molecular characterisation of normal karyotype acute myeloid leukemia (NK-AML allows prognostic stratification and potentially can alter treatment choices and pathways. Approximately 45–60% of patients with NK-AML carry NPM1 gene mutations and are associated with a favourable clinical outcome when FLT3-internal tandem duplications (ITD are absent. High resolution melting (HRM is a novel screening method that enables rapid identification of mutation positive DNA samples. Results We developed HRM assays to detect NPM1 mutations and FLT3-ITD and tested diagnostic samples from 44 NK-AML patients. Eight were NPM1 mutation positive only, 4 were both NPM1 mutation and FLT3-ITD positive and 4 were FLT3-ITD positive only. A novel point mutation Y572C (c.1715A>G in exon 14 of FLT3 was also detected. In the group with de novo NK-AML, 40% (12/29 were NPM1 mutation positive whereas NPM1 mutations were observed in 20% (3/15 of secondary NK-AML cases. Sequencing was performed and demonstrated 100% concordance with the HRM results. Conclusion HRM is a rapid and efficient method of screening NK-AML samples for both novel and known NPM1 and FLT3 mutations. NPM1 mutations can be observed in both primary and secondary NK-AML cases.

  12. Salutogenesis and Ayurveda: indications for public health management.

    Science.gov (United States)

    Morandi, Antonio; Tosto, Carmen; Roberti di Sarsina, Paolo; Dalla Libera, Dacia

    2011-12-01

    Ayurveda, the ancient traditional medicine of India, defines health as a state of complete physical, mental and spiritual well-being. The focus of Ayurveda is on a predictive, preventive and personalized medicine. This is obtained through a low-cost personalized counseling about lifestyle measures (diet, activities, etc.), trying to involve the patient directly in the process of healing, increasing his self-awareness and good relationships with other people and nature. The approach of Ayurveda toward positive health shares its features with that of salutogenesis as described by Antonovsky. Prevention strategies pragmatically suggested by Ayurveda - including factors such as promotion of health education, individual awareness, integration of spirituality and ethics in healthcare system- may be applied in public health management, in order to improve perceived and objective life quality, promote healthy aging, limit drugs use (avoiding expensive side-effects) and reduce chronic diseases social costs. Ayurveda has a universal-coverage, being person-centered and consequently intercultural.

  13. Transformation in the management of Danish public-sector

    DEFF Research Database (Denmark)

    Andersen, Vibeke; Hindhede, Anette Lykke

    2016-01-01

    , quality, and safety (Olesen et al., 2008). The authors construct a theoretical model based on the concepts of trust, fairness, and cooperation in order to describe and measure a desired harmonious state of the organization, which is described as “an ability” (Olesen et al., 2008, p. 10). Thus, inspired......, based on assumptions that are often unsustainable. The paradox is that when problems are subject to ambiguity, a space of interpretation arises; when there is an interpretive space, strict measurement is not needed since the conditions and prerequisites therefore cannot be met. In this article, we try...... management tools. In this context, concepts such as social capital are introduced as measurable and progressive organizational tools which have spread like mantras in the public sector in its efforts to meet these challenges. In this article, we analyse this phenomenon in the light of ambiguity as described...

  14. Public or private water management: Experience from different European Countries

    Science.gov (United States)

    Wackerbauer, Johann

    2008-11-01

    Faced with liberalisation proposals and an increasing internationalisation of water resource management, the question arises as to how a change of the regulatory framework would affect the market structure and the supply conditions in this area. While the term "privatisation" relates to the ownership structure of the providers, the term "liberalisation" implies extensive free market ideas. Privatisation involves the outsourcing of public services from the public authorities to a privately organised organisation. Through this, however, nothing needs to change in terms of the market or the intensity of competition for the commodity in question. Within the framework of privatisation it can also occur that the public monopoly is only transferred to a private monopoly. The term "liberalisation" in addition refers to the basic regulatory constraints: liberalisation signifies the cessation of limitations to competition and supply monopolies, and open competition between several suppliers for the consumers. In the EU-15, the only country where the provision of operational services in the water supply has been totally passed to the private sector is the UK, but this is only true for UK and Wales. Another singular case is France, where there is a mix of mainly private operating companies and municipalities which have divided the regional supply areas among themselves. In six other EU-15 countries where some privatisation took place, either the municipalities or (majority) publicly owned companies are controlling water supply. In the remaining seven countries, the water supply is organised by municipality companies only. In an international comparison, there are three basic models for the regulation of natural monopolies in the public water supply: the Anglo-Saxon, the French and the German model. The delimitation between supervisory bodies and operations in the water supply is strongest in the first model and weakest in the last. This has led to three basic types of

  15. Managing across Public­Private Partnerships: A Review of Implementation in China and Australia

    Directory of Open Access Journals (Sweden)

    Loo-See Beh

    2015-12-01

    Full Text Available Public-private partnership is about governance in the contemporary public service and public interest in public administration with the participation of private sector in the market economy in establishing strategic partnerships in responsible economic management of public services. This article provides an overview of the implementation of public-private partnerships and how these evidences have been managed across China (including Hong Kong SAR and Australia. It also depicts the key challenges of managing them in both countries given their different stages of maturity in implementation framework of regulation and evaluation.

  16. ANALYSIS OF THE PUBLIC MANAGEMENT ADMINISTRATION IN ROMANIA BASED ON DIAGNOSTICS AND SWOT ANALYSIS

    Directory of Open Access Journals (Sweden)

    ANCA JARMILA GUŢĂ

    2015-10-01

    Full Text Available The paper identifies the strengths and weaknesses points existing in a public organization at the five management functions : planning, organization, coordination, training and control. It also done a PEST analysis of public management in Romania and it proposes a global model diagnosis and SWOT analysis for a public service.

  17. The Translation of Accrual Accounting and Budgeting and the Reconfiguration of Public Sector Accountants' Identities

    DEFF Research Database (Denmark)

    D. Becker, Sebastian; Jagalla, Tobias; Skærbæk, Peter

    2014-01-01

    -Network-Theory (ANT) and its concept of translation, this study seeks to explain how PSAs’ identities were transformed through the introduction of Accrual Output-Based Budgeting (AOBB) in two German states. Our analysis shows that the change of accounting regime was not a straightforward one, but rather involved......Under the umbrella of New Public Management (NPM) and managerialism, the last three decades have seen a widespread transformation of public sector accounting and budgeting from a cash to an accrual basis. Much of the ensuing research, however, has focused more on technical evaluations...... of these programmes and less on informing our knowledge of the interaction between such programmes and accountants. As public sector accountants (PSAs) are central entities in such programmes, the purpose of this paper is to focus on the reconfiguration of their identities. Using the theoretical lens of Actor...

  18. Measuring integrated pest management programs for public buildings.

    Science.gov (United States)

    Greene, Albert; Breisch, Nancy L

    2002-02-01

    Integrated pest management (IPM) tends to be perceived by different stakeholder groups either as a methodology for effective pest control or as an ideology of responsible environmental stewardship. The IPM process has never been subjected to a rigorous empirical test as a control methodology in buildings; published studies have either tested isolated program components or have presented uncontrolled, sequential descriptions of IPM replacing traditional pest control service procedures. Because ideological measurement is simpler, cheaper, and more relevant than methodological testing to evaluate structural IPM performance in the public sector, data on pesticide use/risk and customer satisfaction, rather than control efficacy, are used by the General Services Administration (GSA) IPM program to demonstrate success compatible with Government Performance and Results Act (GPRA) guidelines. Implementation of IPM in 1989 resulted in significant decreases both in quantities of insecticide applied indoors and requests for pest control service by building occupants throughout the first decade of the program. Although these results do not provide an empirical test of structural IPM methodological superiority as a means of reducing pest populations, they indicate that replacing sprayed insecticide formulations with baits and using client reporting as the primary pest surveillance method can successfully achieve the policy goals of a large-scale IPM program for public buildings.

  19. Simultaneous detection of mutations and copy number variation of NPM1 in the acute myeloid leukemia using multiplex ligation-dependent probe amplification

    Energy Technology Data Exchange (ETDEWEB)

    Marcinkowska-Swojak, Malgorzata, E-mail: m-marcinkowska@o2.pl [European Center of Bioinformatics and Genomics, Institute of Bioorganic Chemistry, Polish Academy of Sciences, Z. Noskowskiego 12/14, 61-704 Poznan (Poland); Handschuh, Luiza, E-mail: luizahan@ibch.poznan.pl [European Center of Bioinformatics and Genomics, Institute of Bioorganic Chemistry, Polish Academy of Sciences, Z. Noskowskiego 12/14, 61-704 Poznan (Poland); Department of Hematology and Bone Marrow Transplantation, Poznan University of Medical Sciences, Szamarzewskiego 82/84, 60-569 Poznan (Poland); Wojciechowski, Pawel, E-mail: Pawel.Wojciechowski@cs.put.poznan.pl [European Center of Bioinformatics and Genomics, Institute of Bioorganic Chemistry, Polish Academy of Sciences, Z. Noskowskiego 12/14, 61-704 Poznan (Poland); Institute of Computing Science, Poznan University of Technology, Piotrowo 2, 60-965 Poznan (Poland); Goralski, Michal, E-mail: mgoralsk@ibch.poznan.pl [European Center of Bioinformatics and Genomics, Institute of Bioorganic Chemistry, Polish Academy of Sciences, Z. Noskowskiego 12/14, 61-704 Poznan (Poland); Tomaszewski, Kamil, E-mail: kamil.tomaszewsky@gmail.com [European Center of Bioinformatics and Genomics, Institute of Bioorganic Chemistry, Polish Academy of Sciences, Z. Noskowskiego 12/14, 61-704 Poznan (Poland); Kazmierczak, Maciej, E-mail: maciej.kazmierczak@onet.eu [Department of Hematology and Bone Marrow Transplantation, Poznan University of Medical Sciences, Szamarzewskiego 82/84, 60-569 Poznan (Poland); Lewandowski, Krzysztof, E-mail: krzysztof.lewandowski@skpp.edu.pl [Department of Hematology and Bone Marrow Transplantation, Poznan University of Medical Sciences, Szamarzewskiego 82/84, 60-569 Poznan (Poland); Komarnicki, Mieczyslaw, E-mail: mak7@pro.onet.pl [Department of Hematology and Bone Marrow Transplantation, Poznan University of Medical Sciences, Szamarzewskiego 82/84, 60-569 Poznan (Poland); and others

    2016-04-15

    Highlights: • The NPM1 mutations were detected exclusively in AML accounting for 25% of cases. • The NPM1 gene did not reveal any copy number alterations. • The NPM1mut+ assay is a reliable test for the analysis of mutations and CNA in NPM1. - Abstract: The NPM1 gene encodes nucleophosmin, a protein involved in multiple cell functions and carcinogenesis. Mutation of the NPM1 gene, causing delocalization of the protein, is the most frequent genetic lesion in acute myeloid leukemia (AML); it is considered a founder event in AML pathogenesis and serves as a favorable prognostic marker. Moreover, in solid tumors and some leukemia cell lines, overexpression of the NPM1 gene is commonly observed. Therefore, the purpose of this study was to develop a new method for the detection of NPM1 mutations and the simultaneous analysis of copy number alterations (CNAs), which may underlie NPM1 gene expression deregulation. To address both of the issues, we applied a strategy based on multiplex ligation-dependent probe amplification (MLPA). A designed NPM1mut+ assay enables the detection of three of the most frequent NPM1 mutations: A, B and D. The accuracy of the assay was tested using a group of 83 samples from Polish patients with AML and other blood-proliferative disorders. To verify the results, we employed traditional Sanger sequencing and next-generation transcriptome sequencing. With the use of the NPM1mut+ assay, we detected mutations A, D and B in 14, 1 and 0 of the analyzed samples, respectively. All of these mutations were confirmed by complementary sequencing approaches, proving the 100% specificity and sensitivity of the proposed test. The performed sequencing analysis allowed the identification of two additional rare mutations (I and ZE). All of the mutations were identified exclusively in AML cases, accounting for 25% of those cases. We did not observe any CNAs (amplifications) of the NPM1 gene in the studied samples, either with or without the mutation. The

  20. Oncogenic tyrosine kinase NPM/ALK induces activation of the MEK/ERK signaling pathway independently of c-Raf.

    Science.gov (United States)

    Marzec, M; Kasprzycka, M; Liu, X; Raghunath, P N; Wlodarski, P; Wasik, M A

    2007-02-01

    The mechanisms of cell transformation mediated by the highly oncogenic, chimeric NPM/ALK tyrosine kinase remain only partially understood. Here we report that cell lines and native tissues derived from the NPM/ALK-expressing T-cell lymphoma (ALK+ TCL) display phosphorylation of the extracellular signal-regulated protein kinase (ERK) 1/2 complex. Transfection of BaF3 cells with NPM/ALK induces phosphorylation of EKR1/2 and of its direct activator mitogen-induced extracellular kinase (MEK) 1/2. Depletion of NPM/ALK by small interfering RNA (siRNA) or its inhibition by WHI-154 abrogates the MEK1/2 and ERK1/2 phosphorylation. The NPM/ALK-induced MEK/ERK activation is independent of c-Raf as evidenced by the lack of MEK1/2 and ERK1/2 phosphorylation upon c-Raf inactivation by two different inhibitors, RI and ZM336372, and by its siRNA-mediated depletion. In contrast, ERK1/2 activation is strictly MEK1/2 dependent as shown by suppression of the ERK1/2 phosphorylation by the MEK1/2 inhibitor U0126. The U0126-mediated inhibition of ERK1/2 activation impaired proliferation and viability of the ALK+ TCL cells and expression of antiapoptotic factor Bcl-xL and cell cycle-promoting CDK4 and phospho-RB. Finally, siRNA-mediated depletion of both ERK1 and ERK2 inhibited cell proliferation, whereas depletion of ERK 1 (but not ERK2) markedly increased cell apoptosis. These findings identify MEK/ERK as a new signaling pathway activated by NPM/ALK and indicate that the pathway represents a novel therapeutic target in the ALK-induced malignancies.