WorldWideScience

Sample records for publ astron soc

  1. Intro. til Operationsanalyse Diplom M Publ 1115

    DEFF Research Database (Denmark)

    Rasmussen, Annelise

    1999-01-01

    Arbejdsgang i et operationsanalyseprojekt. Dokumentation af arbejdet. En engelsk oversættelse af kompendiet ligger som Diplom M Publ nr 1114......Arbejdsgang i et operationsanalyseprojekt. Dokumentation af arbejdet. En engelsk oversættelse af kompendiet ligger som Diplom M Publ nr 1114...

  2. Observatorio Astronómico Nacional, Colombia

    Science.gov (United States)

    Murdin, P.

    2000-11-01

    The Observatorio Astronómico Nacional (OAN) was founded by José Celestino Mutis in the framework of the `Expedicion Botanica' on 20 August 1803. His first astronomer was Francisco Jose de Caldas. By the turn of the century, Julio Garavito worked in celestial mechanics—a crater on the far side of the Moon bears his name....

  3. SOCS, inflammation and autoimmunity

    Directory of Open Access Journals (Sweden)

    Akihiko eYoshimura

    2012-03-01

    Full Text Available Cytokines play essential roles in innate and adaptive immunity. However, excess cytokines or dysregulation of cytokine signaling can cause a variety of diseases, including allergies, autoimmune diseases, inflammation, and cancer. Most cytokines utilize the so-called Janus kinase-signal transducers and activators of transcription (JAK-STAT pathway. This pathway is negatively regulated by various mechanisms including suppressors of cytokine signaling (SOCS proteins. SOCS proteins bind to JAK or cytokine receptors, thereby suppressing further signaling events. Especially, SOCS1 and SOCS3 are strong inhibitors of JAK, because these two contain kinase inhibitory region (KIR at the N-terminus. Studies using conditional knockout mice have shown that SOCS proteins are key physiological as well as pathological regulators of immune homeostasis. Recent studies have also demonstrated that SOCS1 and SOCS3 are important regulators of helper T cell differentiation and functions.

  4. Gravitational redshift experiment on RadioAstron

    Science.gov (United States)

    Litvinov, Dmitry; Bietenholz, Michael; Rudenko, Valentin; Biriukov, Alexander; Kauts, Vladimir; Kulagin, Victor; Bartel, Norbert; Gwinn, Carl; Cannon, Wayne

    The RadioAstron space radio telescope offers a possibility for testing the gravitational redshift effect with an accuracy of better than 10(-5) , thus, improving the result of the Gravity Probe A mission by at least an order of magnitude. However, RadioAstron’s communications and frequency transfer system doesn’t allow for a direct application of the nonrelativistic Doppler and tropospheric compensation scheme used in the Gravity Probe A experiment. This results in a degradation of the redshift test accuracy to approximately 1%. We discuss two approaches to overcome this difficulty and present preliminary results based on data obtained during special observing sessions scheduled for testing the new techniques.

  5. Observatorio Astronómico De Cantabria

    Science.gov (United States)

    Domínguez, R. M.; Carrera, F. J.

    The Astronomical Observatory of Cantabria is a center of the Consejería de Medio Ambiente del Gobierno de Cantabria managed by the Centro de Investigación del Medio Ambiente (CIMA), an autonomous organism which depends on such Consejería. The development of different activities of the Observatory is a joint collaboration between the University of Cantabria and the Agrupación Astronómica Cántabra (AstroCantabria). As part of the University of Cantabria, the Instituto de Física de Cantabria (IFCA, CSIC-UC) is in charge of the direction, management and coordination of scientific, observational, educational and outreach activities of the Observatory. AstroCantabria takes care of the outreach activities for the general public as well as the astronomical observations. In addition, it is responsible for the calibration and maintenance of the astronomical instrumentation of the Observatory. The Astronomical Observatory of Cantabria is located on the Southern edge of the Comunidad Autónoma de Cantabria, on the high plateau of La Lora (Valderredible county), at an altitude of 1,080m, with longitude 3∘ 56 ' 36' W and latitude 42∘ 46 ' 18' N. Rocamundo is the closest town. The Observatory aims to become a center of reference for scientific, observational, educational and public outreach activities in Cantabria. In the near future, an observational proposal system for outside users will be set in place.

  6. SOC and Fractal Geometry

    Science.gov (United States)

    McAteer, R. T. J.

    2013-06-01

    When Mandelbrot, the father of modern fractal geometry, made this seemingly obvious statement he was trying to show that we should move out of our comfortable Euclidean space and adopt a fractal approach to geometry. The concepts and mathematical tools of fractal geometry provides insight into natural physical systems that Euclidean tools cannot do. The benet from applying fractal geometry to studies of Self-Organized Criticality (SOC) are even greater. SOC and fractal geometry share concepts of dynamic n-body interactions, apparent non-predictability, self-similarity, and an approach to global statistics in space and time that make these two areas into naturally paired research techniques. Further, the iterative generation techniques used in both SOC models and in fractals mean they share common features and common problems. This chapter explores the strong historical connections between fractal geometry and SOC from both a mathematical and conceptual understanding, explores modern day interactions between these two topics, and discusses how this is likely to evolve into an even stronger link in the near future.

  7. The RadioAstron Dedicated DiFX Distribution

    Directory of Open Access Journals (Sweden)

    Gabriele Bruni

    2016-10-01

    Full Text Available Distributed FX-architecture (DiFX is a software Very Long Baseline Interferometry (VLBI correlator currently adopted by several main correlation sites around the globe. After the launch of the RadioAstron Space-VLBI mission in 2011, an extension was necessary to handle processing of an orbiting antenna, to be correlated with supporting ground arrays. Here, we present a branch of the main DiFX distribution (2.4, uploaded on the publicly available repository during July 2016, that the Max Planck Institute for Radio Astronomy (MPIfR developed to process data of the three key active galactic nuclei (AGN-imaging RadioAstron science projects, as well as part of the AGN survey project, and General Observing Time (GOT projects proposed since Announcement of Opportunity 2 (AO-2, July 2014–July 2015. It can account for general relativistic correction of an orbiting antenna with variable position/velocity, providing a routine to convert the native RadioAstron Data Format (RDF format to the more common Mark5 B (M5B. The possibility of introducing a polynomial clock allows one to mitigate the effects of spacecraft acceleration terms in near-perigee observations. Additionally, since for the first time polarimetry on space-baselines is available thanks to RadioAstron, this DiFX branch allows one to include the spacecraft orientation information at the correlation stage, in order to perform proper polarization calibration during data reduction. Finally, a fringe-finding algorithm able to manage an arbitrarily large fringe-search window is included, allowing one to increase the search space normally adopted by common software packages like HOPS.

  8. Alfabetización astronómica

    Science.gov (United States)

    Tignanelli, H.

    A fines de 1991, en una revista de educación en ciencias, José L. Sérsic reflexionaba acerca de los problemas que enfrentaría la enseñanza de los conocimientos astronómicos en nuestro país, en los umbrales del Siglo XXI. Entonces postulaba como un objetivo mínimo, que los jóvenes deberían mostrar signos claros de que se hallan astronómicamente alfabetizados. Era el año en que se realizaba por primera vez una Asamblea General de I.A.U. en Buenos Aires, una oportunidad de singulares características para la comunidad astronómica local y, simultáneamente el comienzo de un cambio radical en la estructura del sistema educativo argentino. ?`Contempla ese cambio el objetivo que postulara Sérsic? ?`Estamos en condiciones de afirmar que estamos en camino de lograrlo? ?`Con qué parámetros?. Presentamos aquí un panorama general sobre algunas de las acciones realizadas en función de alcanzar esa alfabetización científica, analizando exclusivamente la actividad de enseñanza hasta el nivel universitario, sin detenernos en el mismo, ya que lo consideramos una instancia superior e independiente de aquella alfabetización. Tampoco nos referiremos a la tarea de difusión, divulgación o popularización de la Astronomía, ya que su condición de asistemática y subjetiva no es evaluable en términos de la formación integral de un individuo.

  9. Guía astronómica

    OpenAIRE

    2003-01-01

    Esta Guía Astronómica es una versión de mis conferencias en el Taller de Astronomía desde 1985 y en el curso de Contexto en Astronomía desde 2000, dos actividades ofrecidas por la Universidad Nacional de Colombia en Manizales, como espacios disponibles para la comunidad académica y para los aficionados a la astronomía. Por esa razón, este texto propio de la vida universitaria, ha evolucionado hasta encontrar el lenguaje sencillo y la medida adecuada en la extensión y profundidad de los tem...

  10. Aniversarios astronómicos en Cananea, Sonora

    Directory of Open Access Journals (Sweden)

    Raúl Pérez – Enríquez

    2013-06-01

    Full Text Available El 21 de marzo de 1913, en la ciudad de México, nació Guillermo Haro Barraza y el 27 de abril de 1988, se inauguró el Observatorio Astrofísico Guillermo Haro, en Cananea, Sonora. Estos dos muy importantes aniversarios astronómicos se conmemoraron el pasado 27 de abril. Aquí se da cuenta de la relevancia de ambos festejos, de la fructuosa vida del homenajeado y de las actividades desarrolladas ese día allá donde está instalada “Una mina de estrellas”.

  11. SOC 120 ASH Tutorial course/ Uoptutorial

    OpenAIRE

    Michael Crichton

    2015-01-01

    For more course tutorials visit www.uoptutorial.com     SOC 120 WEEK 1 DQ 1 RELATIVISM SOC 120 WEEK 1 DQ 2 EGOISM AND ALTRUISM SOC 120 WEEK 2 DQ 1 SCHOOL PRAYER SOC 120 WEEK 2 DQ 2 RESPONSIBILITY AND REWARD SOC 120 WEEK 2 RELATIVISM AND MORALITY SOC 120 WEEK 3 DQ 1 DEATH PENALTY SOC 120 WEEK 3 DQ 2 FUTURE GENERATIONS AND DEVELOPMENT SOC 120 WEEK 3 ROUGH DRAFT OF FINAL PAPER ON ETHICS THEORY SOC 120 WEEK 4 DQ 1 PRESUMPTION OF INNOCENCE ...

  12. SOC Testing Methodology and Practice

    CERN Document Server

    Wu, Cheng-Wen

    2011-01-01

    On a commercial digital still camera (DSC) controller chip we practice a novel SOC test integration platform, solving real problems in test scheduling, test IO reduction, timing of functional test, scan IO sharing, embedded memory built-in self-test (BIST), etc. The chip has been fabricated and tested successfully by our approach. Test results justify that short test integration cost, short test time, and small area overhead can be achieved. To support SOC testing, a memory BIST compiler and an SOC testing integration system have been developed.

  13. RadioAstron gravitational redshift experiment: status update

    CERN Document Server

    Litvinov, D A; Bartel, N; Belousov, K G; Bietenholz, M; Biriukov, A V; Cimo, G; Duev, D A; Gurvits, L I; Gusev, A V; Haas, R; Kauts, V L; Kanevsky, B Z; Kovalenko, A V; Kronschnabl, G; Kulagin, V V; Lindqvist, M; Calves, G Molera; Neidhardt, A; Ploetz, C; Pogrebenko, S V; Porayko, N K; Rudenko, V N; Smirnov, A I; Sokolovsky, K V; Stepanyants, V A; Yang, J; Zakhvatkin, M V

    2016-01-01

    A test of a cornerstone of general relativity, the gravitational redshift effect, is currently being conducted with the RadioAstron spacecraft, which is on a highly eccentric orbit around Earth. Using ground radio telescopes to record the spacecraft signal, synchronized to its ultra-stable on-board H-maser, we can probe the varying flow of time on board with unprecedented accuracy. The observations performed so far, currently being analyzed, have already allowed us to measure the effect with a relative accuracy of $4\\times10^{-4}$. We expect to reach $2.5\\times10^{-5}$ with additional observations in 2016, an improvement of almost a magnitude over the 40-year old result of the GP-A mission.

  14. SPECKLE INTERFEROMETRY AT THE OBSERVATORIO ASTRON ́ OMICO NACIONAL. VI.

    Directory of Open Access Journals (Sweden)

    V. G. Orlov

    2015-01-01

    Full Text Available Presentamos mediciones de estrellas dobles mediante interferometría de motas, obtenidas en agosto de 2010 con el telescopio de 1.5 m y en mayo de 2010 con el telescopio de 2.1 m del Observatorio Astronómico Nacional en SPM (México. Reportamos los resultados de 331 mediciones de 321 sistemas, con una magnitud límite para las primarias de V = 12.9. Las separaciones angulares medidas están comprendidas entre 0.13 y 7.39 segundos de arco. 269 pares resultaron tener separaciones de menos de 1 segundo de arco. El error medio en las separaciones es de 0.032 segundos de arco, y en los ángulos de posición, 2 grados. La ambigüedad usual de 180 grados en los ángulos de posición fue corregida para la mayoría de ellos usando observaciones de otros autores.

  15. A Requirement for SOCS-1 and SOCS-3 Phosphorylation in Bcr-Abl-Induced Tumorigenesis

    Directory of Open Access Journals (Sweden)

    Xiaoxue Qiu

    2012-06-01

    Full Text Available Suppressors of cytokine signaling 1 and 3 (SOCS-1 and SOCS-3 are inhibitors of the Janus tyrosine kinase (JAK/signal transducers and activators of transcription (STAT pathway and function in a negative feedback loop during cytokine signaling. Abl transformation is associated with constitutive activation of JAK/STAT-dependent signaling. However, the mechanism by which Abl oncoproteins bypass SOCS inhibitory regulation remains poorly defined. Here, we demonstrate that coexpression of Bcr-Abl with SOCS-1 or SOCS-3 results in tyrosine phosphorylation of these SOCS proteins. Interestingly, SOCS-1 is highly tyrosine phosphorylated in one of five primary chronic myelogenous leukemia samples. Bcr-Abl-dependent tyrosine phosphorylation of SOCS-1 and SOCS-3 occurs mainly on Tyr 155 and Tyr 204 residues of SOCS-1 and on Tyr 221 residue of SOCS-3. We observed that phosphorylation of these SOCS proteins was associated with their binding to Bcr-Abl. Bcr-Abl-dependent phosphorylation of SOCS-1 and SOCS-3 diminished their inhibitory effects on the activation of JAK and STAT5 and thereby enhanced JAK/STAT5 signaling. Strikingly, disrupting the tyrosine phosphorylation of SOCS-1 or SOCS-3 impaired the expression of Bcl-XL protein and sensitized K562 leukemic cells to undergo apoptosis. Moreover, selective mutation of tyrosine phosphorylation sites of SOCS-1 or SOCS-3 significantly blocked Bcr-Abl-mediated tumorigenesis in nude mice and inhibited Bcr-Abl-mediated murine bone marrow transformation. Together, these results reveal a mechanism of how Bcr-Abl may overcome SOCS-1 and SOCS-3 inhibition to constitutively activate the JAK/STAT-dependent signaling, and suggest that Bcr-Abl may critically requires tyrosine phosphorylation of SOCS-1 and SOCS-3 to mediate tumorigenesis when these SOCS proteins are present in cells.

  16. YSO Clusters on Galactic Infrared Loops

    Science.gov (United States)

    Marton, Gábor; Kiss, Zoltán Tamás; Tóth, L. Viktor; Zahorecz, Sarolta; Pásztor, László; Ueno, Munateka; Kitamura, Yoshimi; Tamura, Motohide; Kawamura, Akiko; Onishi, Toshikazu

    The AKARI all sky survey (Murakami et al. Publ. Astron. Soc. Jpn. 59:369, 2007) was investigated for YSO candidates. Distribution of candidate sources have been analysed and compared to that of galactic CO and medium scale structures. Clustering and other inhomogenities have been found.

  17. Measurement of the gravitational redshift effect with RadioAstron satellite

    CERN Document Server

    Birukov, A V; Litvinov, D A; Porayko, N K; Rudenko, V N

    2015-01-01

    RadioAstron satellite admits in principle a testing the gravitational redshift effect with an accuracy of better than $10^{-5}$. It would surpass the result of Gravity Probe A mission at least an order of magnitude. However, RadioAstron's communications and frequency transfer systems are not adapted for a direct application of the non relativistic Doppler and troposphere compensation scheme used in the Gravity Probe A experiment. This leads to degradation of the redshift test accuracy approximately to the level 0.01. We discuss the way to overcome this difficulty and present preliminary results based on data obtained during special observing sessions scheduled for testing the new techniques.

  18. Cost Modeling for SOC Modules Testing

    OpenAIRE

    Balwinder Singh; Arun Khosla; Sukhleen B. Narang

    2013-01-01

    The complexity of the system design is increasing very rapidly as the number of transistors on Integrated Circuits (IC) doubles as per Moore’s law.There is big challenge of testing this complex VLSI circuit, in which whole system is integrated into a single chip called System on Chip (SOC). Cost of testing the SOC is also increasing with complexity. Cost modeling plays a vital role in reduction of test cost and time to market. This paper includes the cost modeling of the SOC Module testing...

  19. VIII Olimpíada Brasileira de Astronomia e Astronáutica

    Science.gov (United States)

    Garcia Canalle, João Batista; Villas da Rocha, Jaime Fernando; Wuensche de Souza, Carlos Alexandre; Pereira Ortiz, Roberto; Aguilera, Nuricel Villalonga; Padilha, Maria De Fátima Catta Preta; Pessoa Filho, José Bezerra; Soares Rodrigues, Ivette Maria

    2007-07-01

    Neste trabalho apresentamos as motivações pelas quais organizamos, em conjunto, pela primeira vez, a Olimpíada Brasileira de Astronomia incluindo a Astronáutica, em colaboração com a Agência Espacial Brasileira. Esta ampliação contribuiu para atrair ainda mais alunos, professores, escolas e patrocinadores para participarem desta Olimpíada. Em 2005 participaram da VIII Olimpíada Brasileira de Astronomia e Astronáutica (VIII OBA) 187.726 alunos distribuídos por 3.229 escolas, pertencentes a todos os estados brasileiros, incluindo o Distrito Federal. O crescimento em número de alunos participantes foi 52,4% maior do que em 2004. Em abril de 2005 organizamos, em Itapecerica da Serra, SP, um curso para os 50 alunos previamente selecionados e participantes da VII OBA e ao final selecionamos, dentre eles, uma equipe de 5 alunos, os quais representaram o Brasil na X Olimpíada Internacional de Astronomia, na China, em outubro de 2005. Ganhamos, pela primeira vez, uma medalha de ouro naquele evento. Em Agosto de 2005, organizamos a VIII Escola de Agosto para 50 alunos e respectivos professores, em Águas de Lindóia, SP, juntamente com a XXXI reunião anual da Sociedade Astronômica Brasileira (SAB). Em novembro de 2005 realizamos a I Jornada Espacial, em São José dos Campos, com 22 alunos e 22 professores selecionados dentre os participantes que melhores resultados obtiveram nas questões de Astronáutica da VIII OBA. Neste trabalho detalhamos os resultados da VIII OBA bem como as ações subseqüentes.

  20. SOC-Ahaccu 曲线-理解SOC 变化的关键

    Institute of Scientific and Technical Information of China (English)

    陈凯

    2016-01-01

    针对目前电池系统测试者面临的衡量BMS 的SOC 估算精度及修正策略问题,首次提出SOC-Ahaccu 曲线,作为理解分析SOC 相关问题的有效工具,并进行了深入探讨。

  1. Contrasting effects of deep ploughing of croplands and forests on SOC stocks and SOC bioavailability

    Science.gov (United States)

    Alcántara, Viridiana; Don, Axel; Vesterdal, Lars; Well, Reinhard; Nieder, Rolf

    2016-04-01

    Subsoils are essential within the global C cycle since they have a high soil organic carbon (SOC) storage capacity due to a high SOC saturation deficit. However, measures for enhancing SOC stocks commonly focus on topsoils. We assessed the long-term stability of topsoil SOC buried in cropland and forest subsoils by deep ploughing. Deep ploughing was promoted until the 1970s for breaking up hardpan and improving soil structure to optimize crop growth conditions. In forests deep ploughing is performed as a site preparation measure for afforestation of sandy soil aiming at increasing water availability in deeper layers and decreasing weed competition by burial of seeds. An effect of deep ploughing was the translocation of topsoil SOC into subsoils, with a concomitant mixing of SOC-poor subsoil material into the "new" topsoil horizon. Deep ploughed croplands and forests represent unique long-term "in-situ incubations" of SOC-rich material in subsoils in order to assess the effect of soil depth on SOC turnover. In this study, we sampled soil from five loamy and five sandy cropland sites as well as from five sandy forest sites, which were ploughed to 55-127 cm depth 25 to 53 years ago. Adjacent, equally managed but conventionally ploughed or not ploughed (forests) subplots were sampled as reference. On average 45 years after the deep ploughing operation, at the cropland sites, the deep ploughed soils contained 42±13 Mg ha-1 more SOC than the reference subplots down to 100 cm depth. On the contrary, at the forest sites, the SOC stocks of the deep ploughed soils contained 18±9 Mg ha-1 less SOC compared to the reference soils on average 38 years deep ploughing. These contrasting results can be explained, on the one hand, by the slower SOC accumulation in the newly formed topsoils of the deep ploughed forest soil (on average 48% lower SOC stocks in topsoil) compared to the croplands (on average 15% lower SOC stocks in topsoil). On the other hand, the buried topsoils at the

  2. Cost Modeling for SOC Modules Testing

    Directory of Open Access Journals (Sweden)

    Balwinder Singh

    2013-08-01

    Full Text Available The complexity of the system design is increasing very rapidly as the number of transistors on Integrated Circuits (IC doubles as per Moore’s law.There is big challenge of testing this complex VLSI circuit, in which whole system is integrated into a single chip called System on Chip (SOC. Cost of testing the SOC is also increasing with complexity. Cost modeling plays a vital role in reduction of test cost and time to market. This paper includes the cost modeling of the SOC Module testing which contains both analog and digital modules. The various test cost parameters and equations are considered from the previous work. The mathematical relations are developed for cost modeling to test the SOC further cost modeling equations are modeled in Graphical User Interface (GUI in MATLAB, which can be used as a cost estimation tool. A case study is done to calculate the cost of the SOC testing due to Logic Built in Self Test (LBIST and Memory Built in Self Test (MBIST. VLSI Test engineers can take the benefits of such cost estimation tools for test planning.

  3. Testing the SOC hypothesis for the magnetosphere

    CERN Document Server

    Watkins, N W; Chapman, S C; Dendy, R O

    2001-01-01

    As noted by Chang, the hypothesis of Self-Organised Criticality provides atheoretical framework in which the low dimensionality seen in magnetosphericindices can be combined with the scaling seen in their power spectra and therecently-observed plasma bursty bulk flows. As such, it has considerableappeal, describing the aspects of the magnetospheric fuelling:storage:releasecycle which are generic to slowly-driven, interaction-dominated, thresholdedsystems rather than unique to the magnetosphere. In consequence, several recentnumerical "sandpile" algorithms have been used with a view to comparison withmagnetospheric observables. However, demonstration of SOC in the magnetospherewill require further work in the definition of a set of observable propertieswhich are the unique "fingerprint" of SOC. This is because, for example, ascale-free power spectrum admits several possible explanations other than SOC. A more subtle problem is important for both simulations and data analysiswhen dealing with multiscale and hen...

  4. The Nuclear Structure of 3C84 with Space VLBI (RadioAstron) Observations

    CERN Document Server

    Giovannini, Gabriele; Savolainen, Tuomas; Nagai, Hiroshi; Giroletti, Marcello; Hada, Kazuhiro; Bruni, Gabriele; Hodgson, Jeffrey; Honma, Mareki; Kino, Motoki; Kovalev, Yuri Y; Krichbaum, Thomas; Lee, Sang-Sung; Lobanov, Andrei; Sohn, Bong Won; Sokolovsky, Kirill; Voitsik, Peter; Zensus, J Anton

    2015-01-01

    The radio galaxy 3C84 is a representative of gamma-ray-bright misaligned active galactic nuclei (AGN) and one of the best laboratories to study the radio properties of subparsec scale jets. We discuss here the past and present activity of the nuclear region within the central 1pc and the properties of subparsec-sized components C1, C2 and C3. We compare these results with the high resolution space-VLBI image at 5GHz obtained with the RadioAstron satellite and we shortly discuss the possible correlation of radio emission with the gamma-ray emission.

  5. Elementos astronómicos en el mundo religioso y funerario ibérico

    OpenAIRE

    Esteban, César

    2002-01-01

    Se presenta un análisis arqueoastronómico de la orientación de las estructuras arquitectónicas así como del horizonte que rodea a 16 yacimientos ibéricos de carácter religioso y funerario. Siete de los lugares estudiados (un 44%) presentan relaciones astronómicas relevantes, principalmente con el orto u ocaso solar en los equinoccios. Por otra parte, se obtiene que la mayoría de los edificios de culto ibéricos no domésticos se encuentran orientados hacia la zona del horizonte donde se produce...

  6. Language Choice on soc.culture.punjab.

    Science.gov (United States)

    Paolillo, John C.

    1996-01-01

    Examines factors influencing language choice on the newsgroup soc.culture.punjab, a forum discussing the culture of the Punjab region of India and Pakistan. Finds that Punjabi is used only with interlocutors who are Punjabi community members. Accounts for limited usage in terms of intergenerational language shift, cultural ambivalence among…

  7. Molecular characterization of two suppressor of cytokine signaling 1 genes (SOCS1a and SOCS1b in chickens

    Directory of Open Access Journals (Sweden)

    Xue XU,Jiannan ZHANG,Juan LI,Yajun WANG

    2015-03-01

    Full Text Available Suppressor of cytokine signaling 1 (SOCS1 protein can inhibit the signal transduction triggered by some cytokines or hormones and thus are important in many physiological/pathological processes, including innate and adaptive immunity, inflammation, and development in mammals. However, there is sparse information about their structure, tissue expression, in birds, where their biological functions remain unknown. In this study, we cloned and characterized two SOCS1 genes (named cSOCS1a and cSOCS1b from chickens. SOCS1a is predicted to encode a 207-amino acid protein, which shares high amino acid sequence identity (64%–67% with human and mouse SOCS1. Besides SOCS1a, a novel SOCS1b gene was also identified in chickens and other non-mammalian vertebrates including Xenopus tropicalis. Chicken SOCS1b is predicted to encode a 212-amino acid protein, which shares only 30%–32% amino acid sequence identity with human SOCS1 and cSOCS1a. RT-PCR assay revealed that both cSOCS1a and cSOCS1b are widely expressed in all chicken tissues. Using a luciferase reporter assay system, we further demonstrated that transient expression of cSOCS1a and cSOCS1b can significantly inhibit chicken growth hormone (GH- or prolactin (PRL-induced luciferase activities of Hep G2 cells expressing cGH receptor (or cPRL receptor, indicating that SOCS1a and SOCS1b proteins can negatively regulate GH/PRL signaling. Taken together, these data suggest that both cSOCS1a and cSOCS1b may function as negative regulators of cytokine/hormone actions, such as modulation of GH/PRL actions in chickens.

  8. Extreme Brightness Temperatures and Refractive Substructure in 3C273 with RadioAstron

    CERN Document Server

    Johnson, Michael D; Gwinn, Carl R; Gurvits, Leonid I; Narayan, Ramesh; Macquart, Jean-Pierre; Jauncey, David L; Voitsik, Peter A; Anderson, James M; Sokolovsky, Kirill V; Lisakov, Mikhail M

    2016-01-01

    Earth-space interferometry with RadioAstron provides the highest direct angular resolution ever achieved in astronomy at any wavelength. RadioAstron detections of the classic quasar 3C273 on interferometric baselines up to 171,000 km suggest brightness temperatures exceeding expected limits from the "inverse-Compton catastrophe" by two orders of magnitude. We show that at 18 cm, these estimates most probably arise from refractive substructure introduced by scattering in the interstellar medium. We use the scattering properties to estimate an intrinsic brightness temperature of 7*10^12 K, which is consistent with expected theoretical limits, but which is ~15 times lower than estimates that neglect substructure. At 6 cm, the substructure influences the measured values appreciably but gives an estimated brightness temperature that is comparable to models that do not account for the substructure. At 1.3 cm, the substructure does not affect the extremely high inferred brightness temperatures, in excess of 10^13 K....

  9. Practical Astronomical Activities during Daytime. (Spanish Title: Actividades Astronómicas Prácticas Diurnas.) Atividades Astronômicas Práticas Diurnas

    Science.gov (United States)

    Jackson, Eric

    2009-12-01

    These daytime astronomy activities arose from research done in New Zealand by a group of teachers and astronomers into the problems of teaching astronomy. This showed that it was generally regarded as a difficult subject to take, traditionally relying on books, films and models. The fortunate may have had a visit to an observatory or planetarium, the adventurous may have attempted an outdoor evening viewing session, which sometimes had weather-related difficulties. The problem of not having many 'hands-on' activities, the feelings of inadequate knowledge, the felt need for astronomical equipment and expertise become too daunting for many teachers to do the subject justice. If astronomy was to be taught then a way around these difficulties needed to be found. Our group, working with teachers and children using the constructivism teaching approach, found that the principles of astronomy could be discovered during the day when the students are at school. Working co-operatively they measured and recorded observations of their shadows caused by the motions and interactions of the nearest star, the Sun (Sol), and our planet, Earth. Because children were involved so personally they were much more interested in the results of the study. Astronomy became enthralling and challenging for both teacher and class after applying their daytime experiences to night time viewing at home and reporting back to class. Estas actividades astronómicas diurnas surgieron de una investigación hecha en NuevaZelandia por un grupo de maestros y astrónomos sobre los problemas de la enseñanza de la Astronomía. Este trabajo mostró que la Astronomía es generalmente considerada una disciplina difícil de enseñar, y tradicionalmente basada en libros, filmes y modelos. Los más afortunados pueden haber efectuado alguna visita a un observatorio o planetario, y los más aventajados pueden tal vez haber intentado una sesión de observación nocturna, las cuales sufren a veces de dificultades

  10. RadioAstron and millimetron space observatories: Multiverse models and the search for life

    Science.gov (United States)

    Kardashev, N. S.

    2017-04-01

    The transition from the radio to the millimeter and submillimeter ranges is very promising for studies of galactic nuclei, as well as detailed studies of processes related to supermassive black holes, wormholes, and possible manifestations of multi-element Universe (Multiverse) models. This is shown by observations with the largest interferometer available—RadioAstron observatory—that will be used for the scientific program forMillimetron observatory. Observations have also shown the promise of this range for studies of the formation and evolution of planetary systems and searches for manifestations of intelligent life. This is caused by the requirements to use a large amount of condensedmatter and energy in large-scale technological activities. This range can also be used efficiently in the organisation of optimal channels for the transmission of information.

  11. Space-VLBI with RadioAstron: new correlator capabilities at MPIfR

    CERN Document Server

    Bruni, G; Alef, W; Lobanov, A; Zensus, J A

    2015-01-01

    DiFX is a correlator for VLBI data based on the FX architecture (first Fourier transform and then cross-multiply). DiFX is a free licensed software written in C++, developed and maintened by an international group of programmers. A new DiFX version (dra) has been developed at Max-Planck-Institut f\\"ur Radioastronomie (MPIfR), in order to manage the correlation of a space-based antenna with ground stations. The dra version is running on the High Performance Computer cluster (HPC) in Bonn, and it is used for the data processing of the three AGN imaging RadioAstron Key Science Projects ongoing, based at the MPIfR.

  12. Analog circuit design for communication SOC

    CERN Document Server

    Tu, Steve Hung-Lung

    2012-01-01

    This e-book provides several state-of-the-art analog circuit design techniques. It presents both empirical and theoretical materials for system-on-a-chip (SOC) circuit design. Fundamental communication concepts are used to explain a variety of topics including data conversion (ADC, DAC, S-? oversampling data converters), clock data recovery, phase-locked loops for system timing synthesis, supply voltage regulation, power amplifier design, and mixer design. This is an excellent reference book for both circuit designers and researchers who are interested in the field of design of analog communic

  13. Research on object-oriented SOC design methodology

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    The growing complexity of System on Chip (SOC) requires a system level specification and design approach. High-level languages such as C+ +/SystemC can play multiple roles in system design as target languages. There are many practical problems in the application of object-oriented methods for this goal. Based on the analysis of traditional and system-level design methodology, a new object-oriented SOC design methodology with object-oriented design patterns is proposed, which emphasizes high-level design and verification. Aiming at the final goal of developing design patterns specific to SOC design, the reuse of design patterns in SOC systems and the capability of new SOC design patterns are discussed. With the illustration of some concrete examples of SOC design patterns, the application of object-oriented design methodology in the SOC design process is presented.

  14. ETHERNET PACKET PROCESSOR FOR SOC APPLICATION

    Directory of Open Access Journals (Sweden)

    Raja Jitendra Nayaka

    2012-07-01

    Full Text Available As the demand for Internet expands significantly in numbers of users, servers, IP addresses, switches and routers, the IP based network architecture must evolve and change. The design of domain specific processors that require high performance, low power and high degree of programmability is the bottleneck in many processor based applications. This paper describes the design of ethernet packet processor for system-on-chip (SoC which performs all core packet processing functions, including segmentation and reassembly, packetization classification, route and queue management which will speedup switching/routing performance. Our design has been configured for use with multiple projects ttargeted to a commercial configurable logic device the system is designed to support 10/100/1000 links with a speed advantage. VHDL has been used to implement and simulated the required functions in FPGA.

  15. Variation tolerant SoC design

    Science.gov (United States)

    Kozhikkottu, Vivek J.

    performance distribution. This task is particularly complex and challenging due to the inter-dependencies between components' execution, indirect effects of shared resources, and interactions between multiple system-level "execution paths". We argue that accurate variation-aware performance analysis requires Monte-Carlo based repeated system execution. Our proposed analysis framework leverages emulation to significantly speedup performance analysis without sacrificing the generality and accuracy achieved by Monte-Carlo based simulations. Our experiments show performance improvements of around 60x compared to state-of-the-art hardware-software co-simulation tools and also underscore the framework's potential to enable variation-aware design and exploration at the system level. Our second contribution addresses the problem of designing variation-tolerant SoCs using recovery based design, a popular circuit design paradigm that addresses variations by eliminating guard-bands and operating circuits at close to "zero margins" while detecting and recovering from timing errors. While previous efforts have demonstrated the potential benefits of recovery based design, we identify several challenges that need to be addressed in order to apply this technique to SoCs. We present a systematic design framework to apply recovery based design at the system level. We propose to partition SoCs into "recovery islands", wherein each recovery island consists of one or more SoC components that can recover independent of the rest of the SoC. We present a variation-aware design methodology that partitions a given SoC into recovery islands and computes the optimal operating points for each island, taking into account the various trade-offs involved. Our experiments demonstrate that the proposed design framework achieves an average of 32% energy savings over conventional worst-case designs, with negligible losses in performance. The third contribution of this thesis introduces disproportionate

  16. The Guieloa Adaptive Optics System for the Observatorio Astronómico Nacional

    Directory of Open Access Journals (Sweden)

    A.M. Watson

    2007-01-01

    Full Text Available Se describen los avances para construir un sistema de ptica adaptativa para el telescopio de 2.1-metros del Observatorio Astron mico Nacional en la Sierra de San Pedro M rtir. El sistema utilizar un espejo deformable de tipo bimorfo de 19 elementos montado sobre una plataforma articulada y un sensor de frente de onda tipo curvatura para estrellas gu a naturales. Guieloa tendr dos modos de operaci n. En modo de ptica adaptativa se espera que proporcionar una correcci n excelente en longitudes de onda mayores a 1.0 m y una correcci n buena entre 0.6 y 0.9 m dependiendo de las condiciones del seeing, aunque la cobertura del cielo ser restringida. En el modo de ptica activa y guiado r pido se espera que proporcionar im genes en el l mite del seeing natural o mejor, y con una cobertura de cielo mucho mayor. Actualmente el sistema se encuentra en la fase de pruebas en el laboratorio y se espera que sea entregado en el observatorio en 2009

  17. Gravitational redshift test with the space radio telescope "RadioAstron"

    Science.gov (United States)

    Biriukov, A. V.; Kauts, V. L.; Kulagin, V. V.; Litvinov, D. A.; Rudenko, V. N.

    2014-11-01

    The space radio telescope "RadioAstron" is equipped with a high performance hydrogen maser frequency standard and thus provides a unique opportunity for a gravitational redshift test. We consider various modes of operation of the on-board scientific equipment and their impact on accuracy of the anticipated experiment. We find that the accuracy of the test is limited by ˜10-2 for the hardware configuration routinely used in radio astronomical observations, which is a consequence of using ballistic data to remove the nonrelativistic Doppler frequency shift from the analyzed signal. On the other hand, the so-called "Semi-coherent" mode of the on-board hardware provides for combining the space and ground maser signals in such a way that the resulting signal carries information about the useful effect but is free from the nonrelativistic Doppler and tropospheric frequency shifts. The proposed compensation scheme, which is different from the one used in the Gravity Probe A experiment, allows for testing the gravitational redshift effect with ˜10-6 accuracy.

  18. Sitios de interés astronómico en el Noroeste Argentino

    Science.gov (United States)

    Recabarren, P.; Muriel, H.; Mosconi, M.; García Lambas, D.; Sarazin, M.; Giovanelli, R.

    Se presenta la distribución geográfica de nubosidad en la región comprendida entre las latitudes 23o y 28o Sur, y las longitudes 66o y 69o Oeste, obtenida a partir del análisis de imágenes GOES, tomadas durante los años 1999 al 2002 inclusive. Del análisis de esta información, se revelan como de gran interés las áreas circundantes a los Salares de Antofalla y de Arizaro, en la región de la Puna, en las provincias de Catamarca y Salta. Se hacen comentarios sobre sitios explorados en estas regiones y sobre las posibilidades de asentamientos de grandes facilidades astronómicas en la región. Se complementa la presentación con información tectónica, topográfica y logística de relevante importancia y, finalmente, se discute sobre la selección de emplazamientos para dos estaciones meteorológicas automáticas de la Universidad de Cornell, en las áreas mencionadas.

  19. SOCS3 and SOCS5 mRNA expressions may predict initial steroid response in nephrotic syndrome children

    Directory of Open Access Journals (Sweden)

    Witold Szaflarski

    2012-01-01

    Full Text Available Suppressors of Cytokine Signaling (SOCS inhibit Signal Transducers and Activators of Transcription (STATs phosphorylation by binding and inhibiting Janus Kinases (JaKs. The aim of the present study was to evaluate the influence of glucocorticosteroids on the JaK/STAT signaling pathway in the leukocytes of nephrotic syndrome (NS patients. The study group was composed of 34 steroid sensitive NS (SSNS children and 20 steroid resistant NS (SRNS subjects. Gene expression was assessed by real-time PCR using pre-designed human JaK/STAT PCR array. Protein expression was evaluated using ELISA assay (plasma concentration and immunofluorescence (in situ protein expression. In SSNS children, the initial increased expression of JaK1, JaK2, JaK3, STAT1, STAT2, STAT6, TYK2, SOCS1, SOCS2, SOCS3, SOCS4 and SOCS5 was reduced back to the control limits. Similarly, in SRNS patients the increased levels of almost all mRNA expressions for the abovementioned genes were decreased, with the exceptions of SOCS3 and SOCS5 expressions. These mRNA expressions were still significantly increased and correlated with early unfavorable course of nephrotic syndrome in children. Plasma levels of SOCS3, SOCS5, IL-6 and IL-20 were significantly increased in SRNS subjects after six weeks of steroids medication compared to SSNS and control participants. We conclude that SOCS3 and SOCS5 increased mRNA expressions might predict initial resistance to steroids in NS patients. (Folia Histochemica et Cytobiologica 2011; Vol. 49, No. 4, pp. 719–728

  20. SOC NANOBASED INTEGRATED WIRELESS SENSOR SYSTEM

    Directory of Open Access Journals (Sweden)

    Penghua Sun

    2014-11-01

    Full Text Available Smart nanotechnology materials have been recently utilized in sensing applications. Carbon nanotube (CNT based SoC sensor systems have potential applications in various fields, including medical, energy, consumer electronics, computers, and HVAC (heating, ventilation, and air conditioning among others. In this study, a nanotechnology multisensory system was designed and simulated using Labview Software. The mathematical models were developed for sensing three physical quantities: temperature, gas, and pressure. Four CNT groups on a chip (two for gas sensor, one for temperature, and a fourth one for pressure were utilized in order to perform sensing multiple parameters. The proposed fabrication processes and the materials used were chosen to avoid the interference of these parameters on each other when detecting one of them. The simulation results were translated into analog voltage from Labview software, transmitted via Bluetooth network, and received on desktop computers within the vicinity of the sensor system. The mathematical models and simulation results showed as high as 95% accuracy in measuring temperature, and the 5% error was caused from the interference of the surrounding gas. Within 7% change in pressure was impacted by both temperature and gas interference.

  1. Expression of SOCS-3 and Its Methylation in Renal Cancer

    Institute of Scientific and Technical Information of China (English)

    YU Jing; ZHAO Li-chun; YAO Song-mei; HE Cheng-yan; LI Hong-jun; KONG Xiang-bo

    2011-01-01

    The expression level of suppressor of cytokine signaling-3(SOCS-3) in human renal carcinoma and its methylation state were investigated. Reverse transcription-polymerase chain reaction(RT-PCR), immuocytochemistry,immunohistochemistry and Western blot were used to detect the expression level of SOCS-3, and the methylation of SOCS gene was investigated by methylation specific PCR in the tissues of i 5 cases of renal carcinoma. Compared to those of the normal renal cell line and specimens, the expression level of SOCS-3 in renal carcinoma was significantly lower or can't be detected(P<0.01). And the methylation of SOCS-3 gene in the tissue of renal carcinoma was significantly higher. The expression of SOCS-3 gene is significantly lower in renal carcinoma and the high methylation of the promoter island of SOCS-3 gene is associated with the lower expression of SOCS-3 gene. It may be one of main mechanisms for the development and progress of renal carcinoma.

  2. SOCS1 Mimetic Peptide Suppresses Chronic Intraocular Inflammatory Disease (Uveitis

    Directory of Open Access Journals (Sweden)

    Chang He

    2016-01-01

    Full Text Available Uveitis is a potentially sight-threatening disease characterized by repeated cycles of remission and recurrent inflammation. The JAK/STAT pathway regulates the differentiation of pathogenic Th1 and Th17 cells that mediate uveitis. A SOCS1 mimetic peptide (SOCS1-KIR that inhibits JAK2/STAT1 pathways has recently been shown to suppress experimental autoimmune uveitis (EAU. However, it is not clear whether SOCS1-KIR ameliorated uveitis by targeting JAK/STAT pathways of pathogenic lymphocytes or via inhibition of macrophages and antigen-presenting cells that also enter the retina during EAU. To further investigate mechanisms that mediate SOCS1-KIR effects and evaluate the efficacy of SOCS1-KIR as an investigational drug for chronic uveitis, we induced EAU in rats by adoptive transfer of uveitogenic T-cells and monitored disease progression and severity by slit-lamp microscopy, histology, and optical coherence tomography. Topical administration of SOCS1-KIR ameliorated acute and chronic posterior uveitis by inhibiting Th17 cells and the recruitment of inflammatory cells into retina while promoting expansion of IL-10-producing Tregs. We further show that SOCS1-KIR conferred protection of resident retinal cells that play critical role in vision from cytotoxic effects of inflammatory cytokines by downregulating proapoptotic genes. Thus, SOCS1-KIR suppresses uveitis and confers neuroprotective effects and might be exploited as a noninvasive treatment for chronic uveitis.

  3. SOCS2 Balances Metabolic and Restorative Requirements during Liver Regeneration.

    Science.gov (United States)

    Masuzaki, Ryota; Zhao, Sophia; Valerius, M Todd; Tsugawa, Daisuke; Oya, Yuki; Ray, Kevin C; Karp, Seth J

    2016-02-12

    After significant injury, the liver must maintain homeostasis during the regenerative process. We hypothesized the existence of mechanisms to limit hepatocyte proliferation after injury to maintain metabolic and synthetic function. A screen for candidates revealed suppressor of cytokine signaling 2 (SOCS2), an inhibitor of growth hormone (GH) signaling, was strongly induced after partial hepatectomy. Using genetic deletion and administration of various factors we investigated the role of SOCS2 during liver regeneration. SOCS2 preserves liver function by restraining the first round of hepatocyte proliferation after partial hepatectomy by preventing increases in growth hormone receptor (GHR) via ubiquitination, suppressing GH pathway activity. At later times, SOCS2 enhances hepatocyte proliferation by modulating a decrease in serum insulin-like growth factor 1 (IGF-1) that allows GH release from the pituitary. SOCS2, therefore, plays a dual role in modulating the rate of hepatocyte proliferation. In particular, this is the first demonstration of an endogenous mechanism to limit hepatocyte proliferation after injury.

  4. Settling-velocity specific SOC distribution on hillslopes

    DEFF Research Database (Denmark)

    Hu, Yaxian; Berhe, Asmeret Asefaw; Fogel, Marilyn L.;

    The net effect of soil erosion by water, as a sink or source of atmospheric CO2, is determined by the spatial (re-)distribution and stability of eroded soil organic carbon (SOC). The depositional position of eroded SOC is a function of the transport distances of soil fractions where the SOC...... is stored. In theory, the transport distances of soil fractions are related to their settling velocities under given flow conditions. Yet, very few field investigations have been conducted to examine the actual movement of eroded soil fractions along hillslopes, let alone the re-distribution pattern of SOC...... shows a coarsening effect immediately below the eroding slope, followed by a fining trend at the slope tail. The 13C values of soil fractions were more positive at the footslope than on the slope shoulder or at the slope tail, suggesting enhanced decomposition rate of fresh SOC input at the footslope...

  5. Pulsar B0329+54: scattering disk resolved by RadioAstron interferometer at 324 MHz

    Science.gov (United States)

    Popov, M.

    Propagation of pulsar radio emission through the interstellar plasma is accompanied with scattering by inhomogeneities of the plasma. The scattering produces a range of effects: angular broadening, pulse broadening, intensity modulation (scintillations), and distortion of radio spectra (diffraction pattern). In this presentation, we will primarily deal with scattering effects affecting interferometric measurements. Pulsars are point like radio sources at angular resolution provided by space VLBI even at largest baseline projections. Therefore, any structure, observed by the space-ground interferometer, is due to scattering effects. The objective of our study was to measure parameters of a scattering disk for the PSR B0329+54 at a frequency of 324 MHz with the space-ground interferometer RadioAstron. Observations were conducted on November 26-29 2012 in four sessions, one hour duration each, with progressively increasing baseline projections of 70, 90,175, and 235 thousand kilometers correspondingly. Only one ground radio telescope observed the pulsar together with the space radio telescope (SRT); it was 100-m telescope in Green Bank (GBT). Notable visibility amplitudes were detected at all baseline projections at a maximum level of 0.05 with the SNR of about 20. It was found that visibility function in delay consists of many isolated unresolved spikes. The overall spread of such spikes in delay corresponds to the scattering disk of about 4 mas at a half wide. Fine structure of the visibility amplitude in delay domain corresponds to a model of amplitude modulated noise (AMN). Fringe rate behavior with time indicates on dominant influence of refraction on traveling ionospheric disturbances (TID).

  6. Expression of the SOCS family in human chronic wound tissues: Potential implications for SOCS in chronic wound healing.

    Science.gov (United States)

    Feng, Yi; Sanders, Andrew J; Ruge, Fiona; Morris, Ceri-Ann; Harding, Keith G; Jiang, Wen G

    2016-11-01

    Cytokines play important roles in the wound healing process through various signalling pathways. The JAK-STAT pathway is utilised by most cytokines for signal transduction and is regulated by a variety of molecules, including suppressor of cytokine signalling (SOCS) proteins. SOCS are associated with inflammatory diseases and have an impact on cytokines, growth factors and key cell types involved in the wound‑healing process. SOCS, a negative regulator of cytokine signalling, may hold the potential to regulate cytokine‑induced signalling in the chronic wound‑healing process. Wound edge tissues were collected from chronic venous leg ulcer patients and classified as non-healing and healing wounds. The expression pattern of seven SOCSs members, at the transcript and protein level, were examined in these tissues using qPCR and immunohistochemistry. Significantly higher levels of SOCS3 (P=0.0284) and SOCS4 (P=0.0376) in non-healing chronic wounds compared to the healing/healed chronic wounds were observed at the transcript level. Relocalisation of SOCS3 protein in the non-healing wound environment was evident in the investigated chronic biopsies. Thus, the results show that the expression of SOCS transcript indicated that SOCS members may act as a prognostic biomarker of chronic wounds.

  7. SOCS3 and its role in associated diseases.

    Science.gov (United States)

    Yin, Yanlin; Liu, Weiwei; Dai, Yalei

    2015-10-01

    Cell-cell communication depends on cytokine and growth factor network. Bound to their receptors on the surface of target cell, these glycoproteins initiate a range of intracellular events. Subsequent dissipation of receptor signaling is essential to ensure the response of the cell does not become pathogenic. The Suppressors of cytokine signaling (SOCS) proteins are a family of proteins induced to attenuate cytokine signal transduction in response to signals from a diverse range of cytokines and growth factors. Current evidence indicates that intracellular JAK-STAT (Janus kinase-signal transducer and activator of transcription) signaling not only governs cytokine-induced immunological responses but also rapidly initiates SOCS expression and its biological functions. This review focuses on current understanding of SOCS3, a member of SOCS family. SOCS3 binds to JAK, certain cytokine receptors in intracellular domain, and some signaling molecules, which results in suppressing further signaling events in the cell. Studies using conditional knockout mice have shown that SOCS3 protein is the key physiological regulator and plays an important pathological role in immune homeostasis. Dysregulation of SOCS3 functions can cause a variety of diseases, including allergy, autoimmune diseases, inflammation and cancer.

  8. Regional SOC inventory in the Belgian loam belt

    Science.gov (United States)

    Stevens, F.; Bogaert, P.; van Wesemael, B.

    2012-04-01

    Soil organic carbon (SOC) is the largest component of the terrestrial carbon pool and plays a vital role in the terrestrial carbon cycle. However, it remains a challenge to accurately quantify SOC dynamics in intensively cultivated landscapes. The general objective of the research is to improve the regional SOC dynamics by taking into account the lateral fluxes of sediments and carbon. The study focuses on the croplands of the Belgian loam belt. The first part of the project consists in constructing a 3-dimensional SOC map from soil profile description and ancillary environmental data. A georeferenced soil database provided soil profile description and analyses across the entire Belgian loam belt. A Monte Carlo method was used to account for the uncertainty in the reported SOC content of each horizon. Different methods permitting to construct continuous distribution of SOC density from bulk horizon measurements were compared. Properties that best characterized the erosion-accumulation pattern in the region were searched in the profile description database. Different topographic indices were computed from digital elevation models to assess the influence of the topography on the SOC distribution. A linear regression analysis was conducted in order to predict the SOC spatial distribution at different depth intervals from soil and terrain properties. Using the resulting model, maps of SOC and other soil properties at different depths, and representative of the situation in ~1960, will be constructed. The total uncertainty will be assessed and the main sources of uncertainty determined. These maps could be used as input data for a processed-based model coupling lateral fluxes of sediment and carbon turnover.

  9. Single SOC Test Challenge for Blu-ray DVD

    Institute of Scientific and Technical Information of China (English)

    Don Blair; Keita Gunji

    2005-01-01

    The Blu-ray DVD single chip SOC architecture, challenging high speed and high fidelity mixed signal test requirements and test solutions are introduced. COT reductions to make this a mass production low cost test approach is also described.

  10. The simple art of SoC design

    CERN Document Server

    Keating, Michael

    2011-01-01

    This book tackles head-on the challenges of digital design in the era of billion-transistor SoCs. It discusses fundamental design concepts in design and coding required to produce robust, functionally correct designs. It also provides specific techniques for measuring and minimizing complexity in RTL code. Finally, it discusses the tradeoff between RTL and high-level (C-based) design and how tools and languages must progress to address the needs of tomorrow's SoC designs.

  11. ExpressionofSOCS3throughoutliverregeneration isnotregulatedbyDNAmethylation

    Institute of Scientific and Technical Information of China (English)

    Gang Guo; Jie Xia; Ji Bao; Huai-Qiang Sun; Yu-Jun Shi; Hong Bu

    2012-01-01

    BACKGROUND: While suppressor of cytokine signaling 3 (SOCS3) plays a crucial role in suppressing dysplasia and tumorigenesis, it also offers a typical instance of DNA methylation in the regulation of gene transcription, since the promoter region of the SOCS3 gene is rich in CpG islands (CGIs). During liver regeneration initiated by partial hepatectomy, SOCS3 acts as a suppressor to balance the acute-phase response and terminate the regeneration. This study aimed to determine whether the variation of SOCS3 expression throughout liver regeneration is also regulated by its DNA methylation. METHODS: We established a 70%partial hepatectomy mouse model and the animals were sacriifced at indicated times to assess the SOCS3 expression. We performed bisulifte sequencing PCR and DNA sequencing to investigate the detailed cytosine methylation in the SOCS3 gene. RESULTS:Within the promoter sequence, 58 CGIs were identiifed and 30 were found variously methylated before or after operation;however, methylation remained at a very low level. No evidence indicated that the total methylation level or the methylation of any CpG site regularly changed throughout liver regeneration. CONCLUSION: DNA methylation or demethylation seems to be a relatively stable modiifcation of cytosine, but not a dynamic and reversible process to regulate gene transcription in daily and acute pathophysiological events.

  12. Impact of vegetation types on soil organic carbon stocks SOC-S in Mediterranean natural areas

    Science.gov (United States)

    Parras-Alcántara, Luis; Lozano-García, Beatriz; Cantudo-Pérez, Marta

    2015-04-01

    Soils play a key role in the carbon geochemical cycle because they can either emit large quantities of CO2 or on the contrary they can act as a store for carbon. Agriculture and forestry are the only activities that can achieve this effect through photosynthesis and the carbon incorporation into carbohydrates (Parras-Alcántara et al., 2013). The Mediterranean evergreen oak Woodland (MEOW - dehesa) is a type of pasture with scattered evergreen and deciduous oak stands in which cereals are often grown under the tree cover. It is a system dedicated to the combined production of Iberian swine, sheep, fuel wood, coal and cork as well as to hunting. These semi-natural areas still preserve some of the primitive vegetation of the Mediterranean oak forests. The dehesa is a pasture where the herbaceous layer is comprised of either cultivated cereals such as oat, barley and wheat or native vegetation dominated by annual species, which are used as grazing resources. These Iberian open woodland rangelands (dehesas) have been studied from different points of view: hydrologically, with respect to soil organic matter content, as well as in relation to gully erosion, topographical thresholds, soil erosion and runoff production, soil degradation and management practices…etc, among others. The soil organic carbon stock capacity depends not only on abiotic factors such as the mineralogical composition and the climate, but also on soil use and management (Parras et al., 2014 and 2015). In Spanish soils, climate, use and management strongly affect the carbon variability, mainly in soils in dry Mediterranean climates characterized by low organic carbon content, weak structure and readily degradable soils. Hontoria et al. (2004) emphasized that the climate and soil use are two factors that greatly influence carbon content in the Mediterranean climate. This research sought to analyze the SOC stock (SOCS) variability in MEOW - dehesa with cereals, olive grove and Mediterranean oak forest

  13. Refining regional SOC estimates: Accounting for erosion induced within field variability of the vertical distribution of SOC.

    Science.gov (United States)

    Meersmans, Jeroen; Quine, Tim

    2013-04-01

    Recently, soil organic carbon (SOC) is considered as a dynamic soil property largely influencing soil quality and global C-cycling. Consequently, accurate mapping of SOC at the regional or national scale becomes an important issue in order to help policymakers in developing an appropriate soil and climate change management strategy. So far, in these studies, only factors determining the spatial and temporal distribution of SOC at the landscape scale, such as soil type, land use (change), climate and agro-management, were considered. Despite the fact that a few recent studies incorporated as well the distribution of SOC with depth, resulting in an improved representation of the 3D distribution of SOC, most studies only considers topsoil and/or are characterized by simple sampling by site at rather coarse resolution. Consequently, they omit quantification of stable subsoil carbon buried in depositional areas and does not allow to clearly identify significant differences of SOC and erosion at the within field scale. Hence, the variability of SOC at smaller scales in complex terrain driven by lateral soil transport processes (such as soil erosion), is still rather understudied and is not (well) presented in existing regional SOC estimates. Nevertheless, incorporating this smaller level of spatial detail will most probably have a major influence on SOC mapping and regional SOC stock dynamics' calculations. Consequently, there exists an urgent need in conducting an appropriate soil sampling strategy considering deeper layers and enabling us to detect significant patterns at detailed spatial levels. In this study we aim to unravel the variation of SOC depth distributions along typical hillslope transects under cropland (Devon, UK) and link these to soil redistribution rates and variations in C input, i.e. below and above ground biomass productivity. The radionuclide isotope Caesium-137 (137Cs) was used as proxy for erosion. Furthermore, a soil sampling strategy was

  14. Determinación astronómica de la Desviación de la Vertical

    Science.gov (United States)

    Pacheco, A. M.; Podestá, R. C.

    A partir de las coordenadas astronómicas de Latitud y Longitud determinadas en la falla geológica de Nikizanga ubicada en las serranías de Pie de Palo, y, en base a un Punto Datum de referencia, se desarrolla la metodología para la determinación de la Desviación de la Vertical, que comprende la reducción de las observaciones astronómicas, transformaciones de coordenadas, aplicación de correcciones y el cálculo definitivo de los valores angulares de la Vertical. Estos estudios se iniciaron a sugerencia del Servicio Internacional de Latitud, International Polar Motion Service (IPMS), con el objeto de obtener en determinados puntos de la Tierra la Desviación de la Vertical y su variación, dentro de la nueva disciplina denominada Astrogeodinámica, con la idea de correlacionar estas variaciones con la predicción de grandes sismos.

  15. EXPRESSION OF SOCS3 AND SOCS5 MRNAS IN PERIPHERAL BLOOD MONONUCLEARS FROM THE PATIENTS WITH BRONCHIAL ASTHMA

    Directory of Open Access Journals (Sweden)

    V. V. Lim

    2014-01-01

    Full Text Available We observed sixty patients with allergic bronchial asthma (ABA and 54 with non-allergic bronchial asthma (NABA. Quantitative SOCS3 and SOCS5 mRNA expression was evaluated by means of real-time PCR. Eighteen healthy persons served as a control group. In patients with bronchial asthma (irrespectively of pathogenetic form, a significant increase of SOCS3 transcription factor expression was detected in peripheral blood mononuclears, as compared with control group. This increase was more pronounced in NABA group. The mRNA SOCS5 level was significantly decreased in bronchial asthma patients, as compared to control group, especially, in ABA subgroup rather than in NABA patients. Thus, an increased expression of SOCS3 mRNA in BA patients could be regarded as a protective antiinflammatory response Decrease of SOCS5 mRNA expression in patients with bronchial asthma (being more pronounced in ABA, may be indicative for a deficiency in negative feedback regulation of gene transcription in allergic bronchial asthma.

  16. Settling-velocity specific SOC distribution on hillslopes

    Science.gov (United States)

    Hu, Yaxian; Asefaw Berhe, Asmeret; Fogel, Marilyn L.; Heckrath, Goswin J.; Kuhn, Nikolaus J.

    2016-04-01

    The net effect of soil erosion by water, as a sink or source of atmospheric CO2, is determined by the spatial (re-)distribution and stability of eroded soil organic carbon (SOC). The depositional position of eroded SOC is a function of the transport distances of soil fractions where the SOC is stored. In theory, the transport distances of soil fractions are related to their settling velocities under given flow conditions. Yet, very few field investigations have been conducted to examine the actual movement of eroded soil fractions along hillslopes, let alone the re-distribution pattern of SOC fractions. Eroding sandy soils and sediment were sampled after a series of rainfall events along a slope on a freshly seeded cropland in Jutland, Denmark. All the soil samples were fractionated into five settling classes using a settling tube apparatus. The spatial distribution of soil settling classes shows a coarsening effect immediately below the eroding slope, followed by a fining trend at the slope tail. The δ13C values of soil fractions were more positive at the footslope than on the slope shoulder or at the slope tail, suggesting enhanced decomposition rate of fresh SOC input at the footslope during or after erosion-induced transport. Overall, our results illustrate that immediate deposition of fast settling soil fractions and the associated SOC at footslopes must be appropriately accounted for in attempts to quantify the role of soil erosion in terrestrial carbon sequestration. A SOC erodibility parameter based on actual settling velocity distribution of eroded fractions is needed to better calibrate soil erosion models.

  17. The collider calamity, publ. by Scientific American

    CERN Multimedia

    2006-01-01

    "For decades, the big guns of American science have been the U.S. Department of Energy's particle collider, which investigate the nature of matter by accelerating subatomic particles and smashing them together." (1 page)

  18. The Role of SOCS in the Development of Tumors

    Directory of Open Access Journals (Sweden)

    Chunlai LIU

    2016-09-01

    Full Text Available Suppressor of cytokine signaling (SOCS family proteins are a group of negative regulatory factors that plays important roles in the negative regulation of cytokine responses by terminating the activation of the JAK-STAT and other signaling pathways. The family is composed of eight structurally related proteins. mainly through the inhibition of the activation of JAK-STAT signaling pathway and regulates cell proliferation, differentiation and apoptosis. In the process of tumor progression, the promoter CG island hypermethylation, gene mutation, gene deletion and inactivation lead to the abnormal expression of SOCS protein make JAK-STAT continuous activation, resulting in the development and metastasis of tumor. Here, we review the SOCS family members found, composition and molecular structure, the domain of the function, and the latest progress of development in tumor. Based on the important role of SOCS in tumor development, SOCS as a negative regulator factor represent a kind of tumor suppressor genes, has become a new target for tumor therapy.

  19. Centro astronómico de Calar-Alto Almería – España

    Directory of Open Access Journals (Sweden)

    Margarit, Salvador

    1980-08-01

    Full Text Available The Basic Agreement of Cooperation in Scientific Research and Technological development signed by the Spanish and West German governments in 1970, served as a framework for the agreement signed in 1972 by the National Astronomical Commission and the Max-Planck Society, for the setting up of the «Spanish-German Astronomical Centre». Construction work was started in 1973 on the Calar-Alto (2,168 m, the highest point in the Sierra de los Filabres in the province of Almería. At present the last of the domed buildings, which is intented to accommodate a 3.5 m diameter Telescope and should go into operation in 1983, is at the completion stage. By this date all work will have been completed, with four domed buildings for telescopes of different sizes and the buildings for laboratory, living quarters, services and workshops needed for the use of the scientific instruments. The 1.52 m diameter National Astronomical Observatory telescope has been installed in a separate building beside the infrastructure of the Spanish-German Astronomical Centre.

    El Convenio Básico de Cooperación en la Investigación Científica y en el Desarrollo tecnológico suscrito entre los gobiernos de España y de la República Federal de Alemania en 1970, sirvió de marco para el acuerdo firmado en 1972 entre la Comisión Nacional de Astronomía y la Sociedad Max-Planck, para el establecimiento del «Centro Astronómico» Hispano-Alemán. En 1973 se iniciaron los trabajos de Obras en Calar-Alto (2.168 m cota máxima de la Sierra de los Filabres en la provincia de Almena. Actualmente se halla en fase de terminación el último de los edificios de Cúpula destinado a albergar un Telescopio de 3,5 m de diámetro y cuya puesta en servicio se prevé en 1983. Para entonces quedará culminada la realización completa con cuatro edificios de Cúpula para telescopios de diferentes tamaños y las edificaciones destinadas a laboratorio, residencia, viviendas, servicios y

  20. Architecture Design of Computing Intensive SoCs

    Institute of Scientific and Technical Information of China (English)

    YUE Yao; ZHANG Chunming; WANG Haixin; BAI Guoqiang; CHEN Hongyi

    2009-01-01

    Most existing system-on-chip (SoC) architectures are for microprocessor-centric designs. They are not suitable for computing intensive SoCs, which have their own configurability, extendibility, perform-ance, and data exchange characteristics. This paper analyzes these characteristics and gives design princi-ples for computing intensive SoCs. Three architectures suitable for different situations are compared with selection criteria given. The architectural design of a high performance network security accelerator (HPNSA) is used to elaborate on the design techniques to fully exploit the performance potential of the ar-chitectures. A behavior-level simulation system is implemented with the C++ programming language to evaluate the HPNSA performance and to obtain the optimum system design parameters. Simulations show that this architecture provides high performance data transfer.

  1. RadioAstron Observations of the Quasar 3C273: a Challenge to the Brightness Temperature Limit

    CERN Document Server

    Kovalev, Y Y; Kellermann, K I; Lobanov, A P; Johnson, M D; Gurvits, L I; Voitsik, P A; Zensus, J A; Anderson, J M; Bach, U; Jauncey, D L; Ghigo, F; Ghosh, T; Kraus, A; Kovalev, Yu A; Lisakov, M M; Petrov, L Yu; Romney, J D; Salter, C J; Sokolovsky, K V

    2016-01-01

    Inverse Compton cooling limits the brightness temperature of the radiating plasma to a maximum of $10^{11.5}$ K. Relativistic boosting can increase its observed value, but apparent brightness temperatures much in excess of $10^{13}$ K are inaccessible using ground-based very long baseline interferometry (VLBI) at any wavelength. We present observations of the quasar 3C273, made with the space VLBI mission RadioAstron on baselines up to 171,000 km, which directly reveal the presence of angular structure as small as 26 $\\mu$as (2.7 light months) and brightness temperature in excess of $10^{13}$ K. These measurements challenge our understanding of the non-thermal continuum emission in the vicinity of supermassive black holes and require much higher jet speeds than are observed.

  2. RadioAstron -- a Telescope with a Size of 300 000 km: Main Parameters and First Observational Results

    CERN Document Server

    Kardashev, N S; 10.1134/S1063772913030025

    2013-01-01

    The Russian Academy of Sciences and Federal Space Agency, together with the participation of many international organizations, worked toward the launch of the RadioAstron orbiting space observatory with its onboard 10-m reflector radio telescope from the Baikonur cosmodrome on July 18, 2011. Together with some of the largest ground-based radio telescopes and a set of stations for tracking, collecting, and reducing the data obtained, this space radio telescope forms a multi-antenna ground-space radio interferometer with extremely long baselines, making it possible for the first time to study various objects in the Universe with angular resolutions a million times better than is possible with the human eye. The project is targeted at systematic studies of compact radio-emitting sources and their dynamics. Objects to be studied include supermassive black holes, accretion disks, and relativistic jets in active galactic nuclei, stellar-mass black holes, neutron stars and hypothetical quark stars, regions of format...

  3. The Double-Astrograph Telescope is working at the Observatorio Astronómico Nacional of Venezuela

    Science.gov (United States)

    Abad, C.; Barroeta, G.; Schenner, H.; Plaza, L.; Ramírez, P.; Lacruz, E.

    2009-05-01

    The Double Astrograph telescope (two 0.5 m lenses) in the Observatorio Astronómico Nacional of Venezuela (OAN) will soon be available for observations to the astronomical comunity. Despite of being placed at the OAN since thirty years ago, together with the three other telescopes installed there, it was not fully assembled. Recent engineering work on it, has got to mecanically balance the telescope and set control of the electric motors for the motion of this instrument. The current positioning and guided motions of the telescope allow for an observational quantification of the different aberrations of the optical system of the instrument. With this in mind, selected fields of stars have been observed with a CCD camera, that was installed at different locations on the focal plane. Here we show a summary of the technical operations and the first observational results, aimed at evaluating the potential of the Double Astrograph for future scientific investigations.

  4. Recent Site Testing Campaign at the Observatorio Astronómico Nacional in San Pedro Mártir

    Directory of Open Access Journals (Sweden)

    R. Michel

    2003-01-01

    Full Text Available Hemos llevado a cabo un nuevo programa para medir el seeing en el Observatorio Astronómico Nacional en San Pedro Mártir. Los resultados obtenidos durante un período de dos años, arrojan una calidad de imagen con mediana de 0.57 segundos de arco y un primer cuartil de 0.46 segundos de arco. Mostramos también que el seeing puede ser muy estable durante toda la noche bajo condiciones excelentes. Las mejores medidas arrojan una mediana de 0.37 segundos de arco, obtenidas de observaciones continuas durante casi nueve horas. Nuestros resultados son comparados con un estudio previo del sitio, encontrándose resultados muy similares.

  5. Analog and mixed signal test techniques for SoCs

    NARCIS (Netherlands)

    Kerkhoff, Hans G.; Kaminska, Bozena

    2003-01-01

    Submicron technologies, enabling the implementation of SoC's, are gaining acceptance and this represents a major step forward in design and test complexity. As a result, new tools and development flows are needed that will be able to handle the greater design and test challenges of increasingly smal

  6. Correct-by-construction approaches for SoC design

    CERN Document Server

    Sinha, Roopak; Basu, Samik

    2013-01-01

    This book describes an approach for designing Systems-on-Chip such that the system meets precise mathematical requirements. The methodologies presented enable embedded systems designers to reuse intellectual property (IP) blocks from existing designs in an efficient, reliable manner, automatically generating correct SoCs from multiple, possibly mismatching, components.

  7. SOCS proteins in regulation of receptor tyrosine kinase signaling

    DEFF Research Database (Denmark)

    Kazi, Julhash U.; Kabir, Nuzhat N.; Flores Morales, Amilcar;

    2014-01-01

    . The signaling mediated by RTKs must be tightly regulated by interacting proteins including protein-tyrosine phosphatases and ubiquitin ligases. The suppressors of cytokine signaling (SOCS) family proteins are well-known negative regulators of cytokine receptors signaling consisting of eight structurally similar...

  8. A Generalized SOC-OCV Model for Lithium-Ion Batteries and the SOC Estimation for LNMCO Battery

    Directory of Open Access Journals (Sweden)

    Caiping Zhang

    2016-11-01

    Full Text Available A state-of-charge (SOC versus open-circuit-voltage (OCV model developed for batteries should preferably be simple, especially for real-time SOC estimation. It should also be capable of representing different types of lithium-ion batteries (LIBs, regardless of temperature change and battery degradation. It must therefore be generic, robust and adaptive, in addition to being accurate. These challenges have now been addressed by proposing a generalized SOC-OCV model for representing a few most widely used LIBs. The model is developed from analyzing electrochemical processes of the LIBs, before arriving at the sum of a logarithmic, a linear and an exponential function with six parameters. Values for these parameters are determined by a nonlinear estimation algorithm, which progressively shows that only four parameters need to be updated in real time. The remaining two parameters can be kept constant, regardless of temperature change and aging. Fitting errors demonstrated with different types of LIBs have been found to be within 0.5%. The proposed model is thus accurate, and can be flexibly applied to different LIBs, as verified by hardware-in-the-loop simulation designed for real-time SOC estimation.

  9. The SOCS2 Ubiquitin Ligase Complex Regulates Growth Hormone Receptor Levels

    DEFF Research Database (Denmark)

    Vesterlund, Mattias; Zadjali, Fahad; Persson, Torbjörn

    2011-01-01

    that SOCS2 is part of a multimeric complex with intrinsic ubiquitin ligase activity. Mutational analysis shows that the interaction with Elongin B/C controls SOCS2 protein turnover and affects its molecular activity. Increased GHR levels were observed in livers from SOCS2(-/-) mice and in the absence...... to be responsible for the interaction with SOCS2, but only Y487 to account for the effects of SOCS2. The demonstration that SOCS2 is an ubiquitin ligase for the GHR unveils the molecular basis for its physiological actions....

  10. Differential Effects of Conservational Management on SOC Accumulation in the Grasslands of China.

    Science.gov (United States)

    Zhang, Ping; Tang, Jie; Sun, Wenjuan; Yu, Yongqiang; Zhang, Wen

    2015-01-01

    Conservational management practices in grasslands have been considered one of the efficient options to enhance the soil organic carbon (SOC) accumulation. However, the SOC changes after the conservational management practices vary significantly under different grassland vegetation types and the environmental conditions. At present, it is not clear how the SOC accumulation changes along the soil profile if conservational management practice was adopted. In this study, we collected 663 paired observational data of SOC changes with and without conservational management practices in grasslands of China from 176 published literatures that has both the surface (0‒20 cm) and subsurface (to 40 cm depth) SOC measurements. The differences of SOC density (SOCD) between pre‒management and post‒management in the vertical soil layers were analyzed in order to establish a quantitative relationship of the SOC changes between the subsurface and the surface. The results revealed that in all grasslands, conservational management practices benefits the SOC accumulation by enhancing 0.43‒1.14 Mg C ha-1 yr-1. But the SOC increment weakened downwards along the soil profile. While the surface SOC was enhanced by 17% after conservational management, the subsurface SOC was enhanced by only 7%. The SOC accumulation was closely correlated with restoration duration, pre-management SOCD and the environmental factors and differed greatly among different grasslands and the practices adopted. The alpine and mountain grassland showed a higher annual SOC increment than the temperate grassland with the annual rate of 1.62 and 0.72 Mg C ha-1 yr-1, respectively. The SOC increment caused by the artificial plantation and the grazing exclusion conservational management was more than 2-fold that of the cropland abandonment and the extensive utilization. With the quantitative relationship of the SOC changes between soil layers, we provide a methodological option to estimate SOC changes to layers

  11. SOCS1 and Regulation of Regulatory T Cells Plasticity

    Directory of Open Access Journals (Sweden)

    Reiko Takahashi

    2014-01-01

    Full Text Available Several reports have suggested that natural regulatory T cells (Tregs lose Forkhead box P3 (Foxp3 expression and suppression activity under certain inflammatory conditions. Treg plasticity has been studied because it may be associated with the pathogenesis of autoimmunity. Some studies showed that a minor uncommitted Foxp3+ T cell population, which lacks hypomethylation at Treg-specific demethylation regions (TSDRs, may convert to effector/helper T cells. Suppressor of cytokine signaling 1 (SOCS1, a negative regulator of cytokine signaling, has been reported to play an important role in Treg cell integrity and function by protecting the cells from excessive inflammatory cytokines. In this review, we discuss Treg plasticity and maintenance of suppression functions in both physiological and pathological settings. In addition, we discuss molecular mechanisms of maintaining Treg plasticity by SOCS1 and other molecules. Such information will be useful for therapy of autoimmune diseases and reinforcement of antitumor immunity.

  12. Selection of key terrain attributes for SOC model

    DEFF Research Database (Denmark)

    Greve, Mogens Humlekrog; Adhikari, Kabindra; Chellasamy, Menaka

    was selected, total 2,514,820 data mining models were constructed by 71 differences grid from 12m to 2304m and 22 attributes, 21 attributes derived by DTM and the original elevation. Relative importance and usage of each attributes in every model were calculated. Comprehensive impact rates of each attribute...... (standh) are the first three key terrain attributes in 5-attributes-model in all resolutions, the rest 2 of 5 attributes are Normal High (NormalH) and Valley Depth (Vall_depth) at the resolution finer than 40m, and Elevation and Channel Base (Chnl_base) coarser than 40m. The models at pixels size at 88m......As an important component of the global carbon pool, soil organic carbon (SOC) plays an important role in the global carbon cycle. SOC pool is the basic information to carry out global warming research, and needs to sustainable use of land resources. Digital terrain attributes are often use...

  13. Fractal Characteristics of Gravity Landform and Its SOC Mechanism

    Institute of Scientific and Technical Information of China (English)

    YAO Lingkan; QI Ying

    2007-01-01

    From the principle of self-organized criticality (SOC), this work presents our current understanding of the relationship between the morphology and the dynamics of the evolution of landforms. First, we validate the assumption: Erosional slopes may be treated as SOC systems. Thus Sand-pile models will reflect the universal process of energy dissipation within the slope accumulation under the self-organizing actions. And the scale and frequency of deposit landforms will be related by Fractal structure. Then, by analyzing the field data, such as landslides, rockfalls and debris flow fans, hi three typical areas, the power law for the magnitude-frequency seems very robust. Furthermore, some problems in application are discussed.

  14. System on a Chip (SoC) Overview

    Science.gov (United States)

    LaBel, Kenneth A.

    2010-01-01

    System-on-a-chip or system on chip (SoC or SOC) refers to integrating all components of a computer or other electronic system into a single integrated circuit (chip). It may contain digital, analog, mixed-signal, and often radio-frequency functions all on a single chip substrate. Complexity drives it all: Radiation tolerance and testability are challenges for fault isolation, propagation, and validation. Bigger single silicon die than flown before and technology is scaling below 90nm (new qual methods). Packages have changed and are bigger and more difficult to inspect, test, and understand. Add in embedded passives. Material interfaces are more complex (underfills, processing). New rules for board layouts. Mechanical and thermal designs, etc.

  15. AMBA Based Advanced DMA Controller for SoC

    Directory of Open Access Journals (Sweden)

    Abdullah Aljumah

    2016-03-01

    Full Text Available this paper describes the implementation of an AMBA Based Advanced DMA Controller for SoC. It uses AMBA Specifications, where two buses AHB and APB are defined and works for processor as system bus and peripheral bus respectively. The DMA controller functions between these two buses as a bridge and allow them to work concurrently. Depending on the speed of peripherals it uses buffering mechanism. Therefore an asynchronous FIFO is used for synchronizing the speed of peripherals. The proposed DMA controller can works in SoC along with processor and achieve fast data rate. The method introduced significant volume of data transfer with very low timing characteristics. Thus it is a better choice in respect of timing and volume of data. These two issues have been resolved under this research study. The results are compared with the AMD processors, like Geode GX 466, GX 500 and GX 533, and the presence and absence of DMA controller with processor is discussed and compared. The DMAC stands to be better alternative in SoC design.

  16. SOCS-1 deficiency does not prevent diet-induced insulin resistance

    DEFF Research Database (Denmark)

    Emanuelli, Brice; Macotela, Yazmin; Boucher, Jérémie

    2008-01-01

    Obesity is associated with inflammation and increased expression of suppressor of cytokine signaling (SOCS) proteins, which inhibit cytokine and insulin signaling. Thus, reducing SOCS expression could prevent the development of obesity-induced insulin resistance. Using SOCS-1 knockout mice, we...... investigated the contribution of SOCS-1 in the development of insulin resistance induced by a high-fat diet (HFD). SOCS-1 knockout mice on HFD gained 70% more weight, displayed a 2.3-fold increase in epididymal fat pads mass and increased hepatic lipid content. This was accompanied by increased mRNA expression...... of leptin and the macrophage marker CD68 in white adipose tissue and of SREBP1c and FAS in liver. HFD also induced hyperglycemia in SOCS-1 deficient mice with impairment of glucose and insulin tolerance tests. Thus, despite the role of SOCS proteins in obesity-related insulin resistance, SOCS-1 deficiency...

  17. Study on the expression of SOCS-1 SOCS-3 in liver and spleen of mice induced by acute organophosphorus pesticide poisoning( AOPP)%SOCS-1 SOCS-3在有机磷中毒鼠肝脾中表达的研究

    Institute of Scientific and Technical Information of China (English)

    欧阳艳红; 李松玲; 宋维; 赵宁; 马中富

    2009-01-01

    S-3水平均升高, 与对照组比较差异有统计学意义(P<0.05).统计分析显示, 肝脏中SOCS-1和SOCS-3 mRNA明显正相关(r=0.922,P<0.01) ,脾脏中SOCS-1和SOCS-3 mRNA明显正相关(r=0.957,P<0.01).结论 AOPP可诱导SOCS-1、SOCS-3在肝脾中表达,不同时间点AOPP中毒小鼠肝脏、脾脏中SOCS-1、SOCS-3 mRNA表达升高趋势一致.

  18. Parque Astronómico de Atacama: An Ideal Site for Millimeter, Submillimeter, and Mid-Infrared Astronomy

    Science.gov (United States)

    Bustos, R.; Rubio, M.; Otárola, A.; Nagar, N.

    2014-12-01

    The area of Chajnantor, at more than 5000 meters altitude in northern Chile, offers unique atmospheric and operational conditions which arguably make it the best site in the world for millimeter, submillimeter, and mid-infrared observatories. Long-term monitoring of the precipitable water vapor (PWV) column on the Chajnantor plateau has shown its extreme dryness with annual median values of 1.1 mm. Simultaneous measurements of PWV on the Chajnantor plateau (5050 m) and on Cerro Chajnantor (5612 m) show that the latter is around 36% lower under normal atmospheric conditions and up to 80% lower than the plateau in the presence of temperature inversion layers. Recently, the Government of Chile has consolidated the creation of the Parque Astron\\'omico de Atacama (Atacama Astronomical Park), an initiative of the Chilean Commission for Science and Technology (CONICYT). This new Parque offers an opportunity for national and international projects to settle within its boundaries, gain access to an extremely dry site that is suitable for observations over a broad spectral range, especially in the millimeter to mid-infrared wavelengths, and benefit from operational and logistical support within a secure legal framework.

  19. RadioAstron Studies of the Nearby, Turbulent Interstellar Plasma With the Longest Space-Ground Interferometer Baseline

    CERN Document Server

    Smirnova, T V; Popov, M V; Gwinn, C R; Anderson, J M; Andrianov, A S; Bartel, N; Deller, A; Johnson, M D; Joshi, B C; Kardashev, N S; Karuppusamy, R; Kovalev, Y Y; Kramer, M; Soglasnov, V A; Zensus, J A; Zhuravlev, V I

    2014-01-01

    RadioAstron space-ground VLBI observations of the pulsar B0950+08, conducted with the 10-m space radio telescope in conjunction with the Arecibo 300-m telescope and Westerbork Synthesis Radio Telescope at a frequency of 324 MHz, were analyzed in order to investigate plasma inhomogeneities in the direction of this nearby pulsar. The observations were conducted at a spacecraft distance of 330,000 km, resulting in a projected baseline of 220,000 km, providing the greatest angular resolution ever achieved at meter wavelengths. Our analysis is based on fundamental behavior of structure and coherence functions. We find that the pulsar shows scintillation on two frequency scales, both much less than the observing frequency; but modulation is less than 100%. We infer that the scattering is weak, but a refracting wedge disperses the scintillation pattern. The refraction angle of this "cosmic prism" is measured as theta_0=1.1 - 4.4 mas, with the refraction direction being approximately perpendicular to the observer vel...

  20. Parque Astron\\'omico de Atacama: An ideal site for millimeter, sub-millimeter, and mid-infrared astronomy

    CERN Document Server

    Bustos, Ricardo; Otárola, Angel; Nagar, Neil

    2014-01-01

    The area of Chajnantor, at more than 5000 meters altitude in northern Chile, offers unique atmospheric and operational conditions which arguably make it the best site in the world for millimeter, sub-millimeter, and mid-infrared observatories. Long-term monitoring of the precipitable water vapor (PWV) column on the Chajnantor plateau has shown its extreme dryness with annual median values of 1.1 mm. Simultaneous measurements of PWV on the Chajnantor plateau (5050 m) and on Cerro Chajnantor (5612 m) show that the latter is around 36% lower under normal atmospheric conditions and up to 80% lower than the plateau in the presence of temperature inversion layers. Recently, the Government of Chile has consolidated the creation of the Parque Astron\\'omico de Atacama (Atacama Astronomical Park), an initiative of the Chilean Commission for Science and Technology (CONICYT). This new Parque offers an opportunity for national and international projects to settle within its boundaries, gain access to an extremely dry site...

  1. "RadioAstron"-A telescope with a size of 300 000 km: Main parameters and first observational results

    Science.gov (United States)

    Kardashev, N. S.; Khartov, V. V.; Abramov, V. V.; Avdeev, V. Yu.; Alakoz, A. V.; Aleksandrov, Yu. A.; Ananthakrishnan, S.; Andreyanov, V. V.; Andrianov, A. S.; Antonov, N. M.; Artyukhov, M. I.; Arkhipov, M. Yu.; Baan, W.; Babakin, N. G.; Babyshkin, V. E.; Bartel', N.; Belousov, K. G.; Belyaev, A. A.; Berulis, J. J.; Burke, B. F.; Biryukov, A. V.; Bubnov, A. E.; Burgin, M. S.; Busca, G.; Bykadorov, A. A.; Bychkova, V. S.; Vasil'kov, V. I.; Wellington, K. J.; Vinogradov, I. S.; Wietfeldt, R.; Voitsik, P. A.; Gvamichava, A. S.; Girin, I. A.; Gurvits, L. I.; Dagkesamanskii, R. D.; D'Addario, L.; Giovannini, G.; Jauncey, D. L.; Dewdney, P. E.; D'yakov, A. A.; Zharov, V. E.; Zhuravlev, V. I.; Zaslavskii, G. S.; Zakhvatkin, M. V.; Zinov'ev, A. N.; Ilinen, Yu.; Ipatov, A. V.; Kanevskii, B. Z.; Knorin, I. A.; Casse, J. L.; Kellermann, K. I.; Kovalev, Yu. A.; Kovalev, Yu. Yu.; Kovalenko, A. V.; Kogan, B. L.; Komaev, R. V.; Konovalenko, A. A.; Kopelyanskii, G. D.; Korneev, Yu. A.; Kostenko, V. I.; Kotik, A. N.; Kreisman, B. B.; Kukushkin, A. Yu.; Kulishenko, V. F.; Cooper, D. N.; Kut'kin, A. M.; Cannon, W. H.; Larionov, M. G.; Lisakov, M. M.; Litvinenko, L. N.; Likhachev, S. F.; Likhacheva, L. N.; Lobanov, A. P.; Logvinenko, S. V.; Langston, G.; McCracken, K.; Medvedev, S. Yu.; Melekhin, M. V.; Menderov, A. V.; Murphy, D. W.; Mizyakina, T. A.; Mozgovoi, Yu. V.; Nikolaev, N. Ya.; Novikov, B. S.; Novikov, I. D.; Oreshko, V. V.; Pavlenko, Yu. K.; Pashchenko, I. N.; Ponomarev, Yu. N.; Popov, M. V.; Pravin-Kumar, A.; Preston, R. A.; Pyshnov, V. N.; Rakhimov, I. A.; Rozhkov, V. M.; Romney, J. D.; Rocha, P.; Rudakov, V. A.; Räisänen, A.; Sazankov, S. V.; Sakharov, B. A.; Semenov, S. K.; Serebrennikov, V. A.; Schilizzi, R. T.; Skulachev, D. P.; Slysh, V. I.; Smirnov, A. I.; Smith, J. G.; Soglasnov, V. A.; Sokolovskii, K. V.; Sondaar, L. H.; Stepan'yants, V. A.; Turygin, M. S.; Turygin, S. Yu.; Tuchin, A. G.; Urpo, S.; Fedorchuk, S. D.; Finkel'shtein, A. M.; Fomalont, E. B.; Fejes, I.; Fomina, A. N.; Khapin, Yu. B.; Tsarevskii, G. S.; Zensus, J. A.; Chuprikov, A. A.; Shatskaya, M. V.; Shapirovskaya, N. Ya.; Sheikhet, A. I.; Shirshakov, A. E.; Schmidt, A.; Shnyreva, L. A.; Shpilevskii, V. V.; Ekers, R. D.; Yakimov, V. E.

    2013-03-01

    The Russian Academy of Sciences and Federal Space Agency, together with the participation of many international organizations, worked toward the launch of the RadioAstron orbiting space observatory with its onboard 10-m reflector radio telescope from the Baikonur cosmodrome on July 18, 2011. Together with some of the largest ground-based radio telescopes and a set of stations for tracking, collecting, and reducing the data obtained, this space radio telescope forms a multi-antenna ground-space radio interferometer with extremely long baselines, making it possible for the first time to study various objects in the Universe with angular resolutions a million times better than is possible with the human eye. The project is targeted at systematic studies of compact radio-emitting sources and their dynamics. Objects to be studied include supermassive black holes, accretion disks, and relativistic jets in active galactic nuclei, stellar-mass black holes, neutron stars and hypothetical quark stars, regions of formation of stars and planetary systems in our and other galaxies, interplanetary and interstellar plasma, and the gravitational field of the Earth. The results of ground-based and inflight tests of the space radio telescope carried out in both autonomous and ground-space interferometric regimes are reported. The derived characteristics are in agreement with the main requirements of the project. The astrophysical science program has begun.

  2. DMPD: Regulation of cytokine signaling by SOCS family molecules. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 14644140 Regulation of cytokine signaling by SOCS family molecules. Fujimoto M, Nak...a T. Trends Immunol. 2003 Dec;24(12):659-66. (.png) (.svg) (.html) (.csml) Show Regulation of cytokine signaling by SOCS family... molecules. PubmedID 14644140 Title Regulation of cytokine signaling by SOCS family molec

  3. Probing the innermost regions of AGN jets and their magnetic fields with RadioAstron. II. Observations of 3C 273 at minimum activity

    Science.gov (United States)

    Bruni, G.; Gómez, J. L.; Casadio, C.; Lobanov, A.; Kovalev, Y. Y.; Sokolovsky, K. V.; Lisakov, M. M.; Bach, U.; Marscher, A.; Jorstad, S.; Anderson, J. M.; Krichbaum, T. P.; Savolainen, T.; Vega-García, L.; Fuentes, A.; Zensus, J. A.; Alberdi, A.; Lee, S.-S.; Lu, R.-S.; Pérez-Torres, M.; Ros, E.

    2017-08-01

    Context. RadioAstron is a 10 m orbiting radio telescope mounted on the Spektr-R satellite, launched in 2011, performing Space Very Long Baseline Interferometry (SVLBI) observations supported by a global ground array of radio telescopes. With an apogee of 350 000 km, it is offering for the first time the possibility to perform μas-resolution imaging in the cm-band. Aims: The RadioAstron active galactic nuclei (AGN) polarization Key Science Project (KSP) aims at exploiting the unprecedented angular resolution provided by RadioAstron to study jet launching/collimation and magnetic-field configuration in AGN jets. The targets of our KSP are some of the most powerful blazars in the sky. Methods: We present observations at 22 GHz of 3C 273, performed in 2014, designed to reach a maximum baseline of approximately nine Earth diameters. Reaching an angular resolution of 0.3 mas, we study a particularly low-activity state of the source, and estimate the nuclear region brightness temperature, comparing with the extreme one detected one year before during the RadioAstron early science period. We also make use of the VLBA-BU-BLAZAR survey data, at 43 GHz, to study the kinematics of the jet in a 1.5-yr time window. Results: We find that the nuclear brightness temperature is two orders of magnitude lower than the exceptionally high value detected in 2013 with RadioAstron at the same frequency (1.4 × 1013 K, source-frame), and even one order of magnitude lower than the equipartition value. The kinematics analysis at 43 GHz shows that a new component was ejected 2 months after the 2013 epoch, visible also in our 22 GHz map presented here. Consequently this was located upstream of the core during the brightness temperature peak. Fermi-LAT observations for the period 2010-2014 do not show any γ-ray flare in conjunction with the passage of the new component by the core at 43 GHz. Conclusions: These observations confirm that the previously detected extreme brightness temperature in

  4. Communication Architecture Synthesis for Multi-bus SoC

    Directory of Open Access Journals (Sweden)

    Abdelkrim Zitouni

    2006-01-01

    Full Text Available In the systems on chip (SoC design, the synthesis of communication architecture constitutes the bottleneck which can affect the performances of the system. Various schemes and protocols can be necessary, just as various topologies of interconnection. To reduce the complexity of the communications refinement, we present in this study a model and a synthesis approach for multi-bus communication architecture containing centralized bridge. The automation of the arbiter synthesis step profited from a detailed attention. This stage generates a hierarchical arbiter integrating various priority arbitration modules. The proposed approach was integrated in a toolbox based environment

  5. Low Noise Readout Circuit for Biosensor SoC

    Institute of Scientific and Technical Information of China (English)

    PAN Yin-song; KONG Mou-fu; LI Xiang-quan; WANG Li

    2008-01-01

    Presented is a low noise interface circuit that is tuned to the needs of self-assembly monolayers biosensor SoC. The correlated double sampling(CDS) unit of the readout circuit can reduce 1/f noise, KTC noise and fixed noise of micro arrays effectively. The circuit is simulated in a 0.6 μm/level 7 standard CMOS process, and the simulated results show the output voltage has a good linearity with the transducing current of the micro arrays. This is a novel circuit including four amplifiers sharing a common half-circuit and the noise reducing CDS unit. It could be widely used for micro array biosensors.

  6. Hardware-Software Co-Simulation for SOC Functional Verification

    Institute of Scientific and Technical Information of China (English)

    YAN Ying-jian; LIU Ming-ye

    2005-01-01

    A hardware-software co-simulation method for system on chip (SOC) design is discussed. It is based on an instruction set simulator (ISS) and an event-driven hardware simulator, and a bus interface model that is described in C language provides the interface between the two. The bus interface model and the ISS are linked into a singleton program the software simulator, which communicate with the hardware simulator through Windows sockets. The implementation of the bus interface model and the synchronization between hardware and software simulator are discussed in detail. Co-simulation control of the hardware simulator is also discussed.

  7. RadioAstron Studies of the Nearby, Turbulent Interstellar Plasma with the Longest Space-Ground Interferometer Baseline

    Science.gov (United States)

    Smirnova, T. V.; Shishov, V. I.; Popov, M. V.; Gwinn, C. R.; Anderson, J. M.; Andrianov, A. S.; Bartel, N.; Deller, A.; Johnson, M. D.; Joshi, B. C.; Kardashev, N. S.; Karuppusamy, R.; Kovalev, Y. Y.; Kramer, M.; Soglasnov, V. A.; Zensus, J. A.; Zhuravlev, V. I.

    2014-05-01

    RadioAstron space-ground very long baseline interferometry observations of the pulsar B0950+08, conducted with the 10 m Space Radio Telescope in conjunction with the Arecibo 300 m telescope and the Westerbork Synthesis Radio Telescope at a frequency of 324 MHz were analyzed in order to investigate plasma inhomogeneities in the direction of this nearby pulsar. The observations were conducted at a spacecraft distance of 330,000 km, resulting in a projected baseline of 220,000 km, providing the greatest angular resolution ever achieved at meter wavelengths. Our analysis is based on fundamental behavior of structure and coherence functions. We find that the pulsar shows scintillation on two frequency scales, both much less than the observing frequency, but modulation is less than 100%. We infer that the scattering is weak, but a refracting wedge disperses the scintillation pattern. The refraction angle of this "cosmic prism" is measured as θ0 = 1.1-4.4 mas, with the refraction direction being approximately perpendicular to the observer velocity. We show that the observed parameters of scintillation effects indicate that two plasma layers lie along the line of sight to the pulsar, at distances of 4.4-16.4 pc and 26-170 pc, and traveling in different directions relative to the line of sight. Spectra of turbulence for the two layers are found to follow a power law with the indices γ1 = γ2 = 3.00 ± 0.08, significantly different from the index expected for a Kolmogorov spectrum of turbulence, γ = 11/3.

  8. Constitutive SOCS-3 expression protects T-cell lymphoma against growth inhibition by IFNalpha

    DEFF Research Database (Denmark)

    Brender, C; Lovato, P; Sommer, V H;

    2005-01-01

    Signal transducer and activator of transcription (Stat)3 is constitutively activated in cutaneous T-cell lymphoma (CTCL), where it protects tumour cells against apoptosis. The constitutive activation of Stat3 leads to a constitutive expression of suppressor of cytokine signalling (SOCS)-3....... In healthy cells, SOCS-3 is transiently expressed following cytokine stimulation and functions as a negative feedback inhibitor of the Stat3-activating kinases. Here, we attempt to resolve the apparent paradox of a simultaneous SOCS-3 expression and Stat3 activation in the same cells. We show that (i) SOCS-3...... expression in tumour cells is equal to or higher than in cytokine-stimulated nonmalignant T cells, (ii) SOCS-3 is not mutated in CTCL, (iii) overexpression of SOCS-3 blocks IFNalpha-mediated growth inhibition without affecting Stat3 activation, growth, and apoptosis, and (iv) inhibition of SOCS-3...

  9. The App SOC plus a tool to estimate and calculate organic carbon in the soil profile

    Directory of Open Access Journals (Sweden)

    Francisco Bautista

    2016-04-01

    Full Text Available In the world, researchers are working very intensively in the development of soil organic carbon (SOC inventories. Soil organic carbon is very important because it constitutes the largest reservoir of carbon in terrestrial ecosystems. Maintaining and increasing soil carbon is an option to reduce the amounts of CO2 in the atmosphere, and thereby, to reduce or mitigate climate change. The SOC is now a topic of great interest hence it is recommended to know the amount of SOC along the profile to select and evaluate those areas that should be preserved. The aims of developing App SOC plus were to eliminate the calculate errors of SOC and to make a tool to estimate SOC in field. The common units of measurement of soil properties were employed: bulk density in mg mL−1, horizon thickness in centimetres, stoniness and organic carbon in percentage. The App SOC plus was developed in the Android platform. App SOC plus involves a three-step process: introduction of soil properties, calculation of SOC to horizon and soil profile, and conversion of units using the international and English systems. As a result, there will no longer be confusions with conversion units using App SOC plus; with App SOC plus the soil organic carbon can now be calculated or/and estimated because it provides instructions (aids to estimate the soil properties necessary to calculate the SOC in the soil profile. You can save time in the calculation of SOC. App SOC plus is a tool for diagnosis in the field.

  10. The SOCS2 ubiquitin ligase complex regulates growth hormone receptor levels.

    Directory of Open Access Journals (Sweden)

    Mattias Vesterlund

    Full Text Available Growth Hormone is essential for the regulation of growth and the homeostatic control of intermediary metabolism. GH actions are mediated by the Growth Hormone Receptor; a member of the cytokine receptor super family that signals chiefly through the JAK2/STAT5 pathway. Target tissue responsiveness to GH is under regulatory control to avoid excessive and off-target effects upon GHR activation. The suppressor of cytokine signalling 2 (SOCS is a key regulator of GHR sensitivity. This is clearly shown in mice where the SOCS2 gene has been inactivated, which show 30-40% increase in body length, a phenotype that is dependent on endogenous GH secretion. SOCS2 is a GH-stimulated, STAT5b-regulated gene that acts in a negative feedback loop to downregulate GHR signalling. Since the biochemical basis for these actions is poorly understood, we studied the molecular function of SOCS2. We demonstrated that SOCS2 is part of a multimeric complex with intrinsic ubiquitin ligase activity. Mutational analysis shows that the interaction with Elongin B/C controls SOCS2 protein turnover and affects its molecular activity. Increased GHR levels were observed in livers from SOCS2⁻/⁻ mice and in the absence of SOCS2 in in vitro experiments. We showed that SOCS2 regulates cellular GHR levels through direct ubiquitination and in a proteasomally dependent manner. We also confirmed the importance of the SOCS-box for the proper function of SOCS2. Finally, we identified two phosphotyrosine residues in the GHR to be responsible for the interaction with SOCS2, but only Y487 to account for the effects of SOCS2. The demonstration that SOCS2 is an ubiquitin ligase for the GHR unveils the molecular basis for its physiological actions.

  11. 类风湿性关节炎患者血清及关节积液SOCS-1、SOCS-3蛋白的含量检测及意义%The content and value of SOCS-1 and SOCS-3 proteins in serum and synovial fluid of patients with rheumatoid arthritis

    Institute of Scientific and Technical Information of China (English)

    林栋; 汪铁军; 钱一龙

    2012-01-01

    Objective To investigate the changes of the levels of serum and synovial fluid SOCS-1, SOCS-3 in patients with rheumatoid arthritis( RA ), and to explore the value of SOCS-1 and SOCS-3 in inflammatory reaction of rheumatoid arthritis. Methods 49 patients with rheumatoid arthritis were divided into active RA group( 26 cases ) and non- active RA group( 23 cases jaccording to disease activity index. The levels of serum and synovial fluid SOCS-1, SOCS-3 were detected by ELISA, while the 20 health)' control were compiled into the control group. Results The levels of serum SOCS-1 and SOCS-3 were significantly higher in RA group than those in control group( P < 0. 01 ), which were significantly higher in active RA group than those in non- active RA group( P < 0. 01, P < 0. 05 ). The levels of synovial fluid SOCS-1 and SOCS-3 were significantly higher in active RA group than those in non- active RA group( P <0. 05 ). The levels of serum SOCS-1 and SOCS-3 were positively correlated with the serum ESR,CRP,RF ( P <0. 01 ,P <0. 05 ). Conclusions SOCS-1 and SOCS-3 may play an important role in the pathological process of inflammatory response in rheumatoid arthritis, which ma)' be related to activity of rheumatoid arthritis.%目的 观察类风湿性关节炎(RA)患者血清及关节液SOCS-1、SOCS-3蛋白含量的变化,探讨其在炎症中的意义.方法 49例类风湿性关节炎患者根据疾病活动性分为活动期组(26例)及缓解期组(23例),采用ELISA法检测其血清及关节液SOCS-1、SOCS-3蛋白含量,并与20例健康体检者(对照组)进行比较.结果 与对照组比较,RA患者中活动期组与缓解期组血清SOCS-1、SOCS-3蛋白含量均明显升高(P<0.01),其中活动期组血清SOCS-1、SOCS-3含量表达较缓解组明显升高(P<0.01、P<0.05);活动期组患者关节积液SOCS-1、SOCS-3蛋白表达较缓解期组明显升高(P<0.05);活动期组患者血清SOCS-1、SOCS-3蛋白水平均与血清ESR、CRP、RF呈正相关(P<0.01、P<0

  12. Design of SOC based on IP core%基于IP的系统芯片(SOC)设计

    Institute of Scientific and Technical Information of China (English)

    薛严冰; 徐晓轩

    2004-01-01

    随着集成电路设计与工艺技术水平的提高,出现了系统芯片(SOC)的概念.本文介绍了基于IP的SOC设计方式的设计流程,指出了其与传统IC设计方法的不同.讨论了支持SOC设计的几种关键技术,并对SOC的技术优势及发展趋势作了全面阐述.

  13. Direct stimulation of bone mass by increased GH signalling in the osteoblasts of Socs2-/- mice.

    Science.gov (United States)

    Dobie, R; MacRae, V E; Huesa, C; van't Hof, R; Ahmed, S F; Farquharson, C

    2014-10-01

    The suppressor of cytokine signalling (Socs2(-/-))-knockout mouse is characterised by an overgrowth phenotype due to enhanced GH signalling. The objective of this study was to define the Socs2(-/-) bone phenotype and determine whether GH promotes bone mass via IGF1-dependent mechanisms. Despite no elevation in systemic IGF1 levels, increased body weight in 4-week-old Socs2(-/-) mice following GH treatment was associated with increased cortical bone area (Ct.Ar) (PGH. Indeed, male Socs2(-/-) mice had increased Ct.Ar (PGH action. Mechanistic studies showed that in osteoblasts and bone of Socs2(-/-) mice, STAT5 phosphorylation was significantly increased in response to GH. Conversely, overexpression of SOCS2 decreased GH-induced STAT5 signalling. Although an increase in Igf1 expression was observed in Socs2(-/-) osteoblasts following GH, it was not evident in vivo. Igf1 expression levels were not elevated in response to GH in 4-week-old mice and no alterations in expression was observed in bone samples of 6-week-old Socs2(-/-) mice. These studies emphasise the critical role of SOCS2 in controlling the local GH anabolic bone effects. We provide compelling evidence implicating SOCS2 in the regulation of GH osteoblast signalling and ultimately bone accrual, which maybe via mechanisms that are independent of IGF1 production in vivo.

  14. 寻常型银屑病患者外周血单个核细胞SOCS-1、SOCS-3 mRNA的表达%The expression of SOCS-1 and SOCS-3 mRNA in patients with psoriasis vulgaris

    Institute of Scientific and Technical Information of China (English)

    郭红卫; 王京滨; 李国明; 李顺凡; 吴志华

    2007-01-01

    目的: 检测细胞因子信号抑制因子SOCS-1、SOCS-3 mRNA在寻常型银屑病患者外周血单个核细胞(PBMC)中的表达.方法: 从20例银屑病患者及20例健康志愿者外周血中分离PBMC,提取RNA,应用逆转录-聚合酶链反应(RT-PCR)方法检测SOCS-1、SOCS-3 mRNA的表达.结果: SOCS-1、SOCS-3 mRNA在银屑病患者中表达,在正常人中无表达,活动期银屑病患者较静止期患者SOCS-1、SOCS-3 mRNA表达增高.结论: SOCS-1、SOCS-3可能在银屑病的Th1免疫反应中发挥作用.

  15. SOCS1 mimetics and antagonists: a complementary approach to positive and negative regulation of immune function

    Directory of Open Access Journals (Sweden)

    Chulbul M. Ahmed

    2015-04-01

    Full Text Available Suppressors of cytokine signaling (SOCS are inducible intracellular proteins that play essential regulatory roles in both immune and non-immune function. Of the eight known members, SOCS1 and SOCS3 in conjunction with regulatory T cells play key roles in regulation of the immune system. Molecular tools such as gene transfections and siRNA have played a major role in our functional understanding of the SOCS proteins where a key functional domain of 12 amino acid residues called the kinase inhibitory region (KIR has been identified on SOCS1 and SOCS3. KIR plays a key role in inhibition of the JAK2 tyrosine kinase which in turn plays a key role in cytokine signaling. A peptide corresponding to KIR (SOCS1-KIR bound to the activation loop of JAK2 and inhibited tyrosine phosphorylation of STAT1α transcription factor by JAK2. Cell internalized SOCS1-KIR is a potent therapeutic in the experimental allergic encephalomyelitis (EAE mouse model of multiple sclerosis and showed promise in a psoriasis model and a model of diabetes associated cardiovascular disease. By contrast, a peptide, pJAK2(1001-1013, that corresponds to the activation loop of JAK2 is a SOCS1 antagonist. The antagonist enhanced innate and adaptive immune response against a broad range of viruses including herpes simplex virus, vaccinia virus, and an EMC picornavirus. SOCS mimetics and antagonists are thus potential therapeutics for negative and positive regulation of the immune system.

  16. Large Catchment Scale Sediment Transport Modelling of SOC Using Environmental Tracers and Remote Sensing

    Science.gov (United States)

    Willgoose, G. R.; Kunkel, V.; Hancock, G. R.; Wells, T.

    2015-12-01

    Soil's potential as a carbon sink for atmospheric CO2 has been widely discussed. Studies of soil organic carbon (SOC) controls, and the subsequent models derived from their findings, have focussed mainly on North American and European regions, and more recently, in regions such as China. In Australia, agricultural practices have led to losses in SOC. This implies that Australian soils have a large potential for increased sequestration of SOC. Building on previous work, here we examine the spatial and temporal variation in soil organic carbon (SOC) and its controlling factors controls across a large catchment of approximately 650 km2 in the Upper Hunter Valley, New South Wales, Australia, using data collected from two sampling campaigns, (April 2006 and June-July 2014). The 2006 data represented a period of long-term drought which effectively ended in 2007 with average and above average subsequent rainfall. In 2007 and 2010 there were a series of extreme rainfall events. 137-Cesium and SOC concentrations were obtained from the sampled soils. Remote sensing using Landsat (30m) and MODIS (250m) NDVI was used to determine if catchment SOC could be predicted using both low and high resolution remote sensing. Relationships between SOC and 137-Cesium for both sampling periods were also quantified. Results indicate that, although moderate resolution (250 m) allows for reasonable prediction of the spatial distribution of SOC, the higher resolution (30 m) improved the strength of the SOC-NDVI relationship. Mean 137-Cesium concentrations were observed to show an increase in deposition at the sample sites over the 8 years between samplings. The relationship between SOC and 137-Cesium, as a surrogate for the erosion and deposition of SOC, suggested that sediment transport and deposition influences the distribution of SOC within the catchment. The increase in 137-Cesium also suggests that increased rainfall and extreme storm events, resulting from climate change, may increase

  17. SOCS3 inhibiting migration of A549 cells correlates with PYK2 signaling in vitro

    Directory of Open Access Journals (Sweden)

    Zhang Qingfu

    2008-05-01

    Full Text Available Abstract Background Suppressor of cytokine signaling 3 (SOCS3 is considered to inhibit cytokine responses and play a negative role in migration of various cells. Proline-rich tyrosine kinase 2 (PYK2 is a non-receptor kinase and has been found crucial to cell motility. However, little is known about whether SOCS3 could regulate PYK2 pro-migratory function in lung cancer. Methods The methylation status of SOCS3 was investigated in HBE and A549 cell lines by methylation-specific PCR. A549 cells were either treated with a demethylation agent 5-aza-2'-deoxycytidine or transfected with three SOCS3 mutants with various functional domains deleted. Besides, cells were pretreated with a proteasome inhibitor β-lactacystin where indicated. The effects of SOCS3 up-regulation on PYK2 expression, PYK2 and ERK1/2 phosphorylations were assessed by western blot using indicated antibodies. RT-PCR was used to estimate PYK2 mRNA levels. Transwell experiments were performed to evaluate cell migration. Results SOCS3 expression was found impaired in A549 cells and higher PYK2 activity was correlated with enhanced cell migration. We identified that SOCS3 was aberrantly methylated in the exon 2, and 5-aza-2'-deoxycytidine restored SOCS3 expression. Reactivation of SOCS3 attenuated PYK2 expression and phosphorylation, cell migration was inhibited as well. Transfection studies indicated that exogenous SOCS3 interacted with PYK2, and both the Src homology 2 (SH2 and the kinase inhibitory region (KIR domains of SOCS3 contributed to PYK2 binding. Furthermore, SOCS3 was found to inhibit PYK2-associated ERK1/2 activity in A549 cells. SOCS3 possibly promoted degradation of PYK2 in a SOCS-box-dependent manner and interfered with PYK2-related signaling events, such as cell migration. Conclusion These data indicate that SOCS3 negatively regulates cell motility and decreased SOCS3 induced by methylation may confer a migration advantage to A549 cells. These results also suggest a

  18. The Impact of Strong Cathodic Polarization on SOC Electrolyte Materials

    DEFF Research Database (Denmark)

    Kreka, Kosova; Hansen, Karin Vels; Jacobsen, Torben

    2016-01-01

    One of the most promising reversible energy conversion/storage technologies is that of Solid Oxide Fuel/Electrolysis Cells (SOFC/SOEC, collectively termed SOC). Long term durability is typically required for such devises to become economically feasible, hence considerable amount of work has...... of impurities at the grain boundaries, electrode poisoning, delamination or cracks of the electrolyte etc., have been observed in cells operated at such conditions, lowering the lifetime of the cell1,2. High polarizations are observed at the electrolyte/cathode interface of an electrolysis cell operated at high...... current density. In case of a cell voltage above 1.6 V, p-type and n-type electronic conductivity are often observed at the anode and cathode respectively3. Hence, a considerable part of the current is lost as leakage through the electrolyte, thus lowering the efficiency of the cell considerably....

  19. The Impact of Strong Cathodic Polarization on SOC Electrolyte Materials

    DEFF Research Database (Denmark)

    Kreka, Kosova; Hansen, Karin Vels; Jacobsen, Torben

    2016-01-01

    of impurities at the grain boundaries, electrode poisoning, delamination or cracks of the electrolyte etc., have been observed in cells operated at such conditions, lowering the lifetime of the cell1,2. High polarizations are observed at the electrolyte/cathode interface of an electrolysis cell operated at high...... current density. In case of a cell voltage above 1.6 V, p-type and n-type electronic conductivity are often observed at the anode and cathode respectively3. Hence, a considerable part of the current is lost as leakage through the electrolyte, thus lowering the efficiency of the cell considerably.......One of the most promising reversible energy conversion/storage technologies is that of Solid Oxide Fuel/Electrolysis Cells (SOFC/SOEC, collectively termed SOC). Long term durability is typically required for such devises to become economically feasible, hence considerable amount of work has...

  20. Impacts of SOC on car-following behavior and travel time in the heterogeneous traffic system

    Science.gov (United States)

    Tang, Tie-Qiao; Xu, Ke-Wei; Yang, Shi-Chun; Ding, Chuan

    2016-01-01

    Since the SOC (state of charge) of the battery of each electric vehicle directly determines whether the battery should be charged/swapped, the SOC may affect the electric vehicle's driving behavior. In this paper, we introduce the SOC of battery into the electric vehicle's driving behavior model and propose a car-following model for electric vehicles, and then use the proposed model to study the effects of the SOC of battery and battery swap on each vehicle's driving behavior in the heterogeneous traffic system consisting of traditional vehicles and electric vehicles. The numerical results show that the proposed model can reproduce some complex traffic phenomena resulted by the SOC of battery and battery swap and that the influences on each vehicle's driving behavior are directly related to the initial traffic state, the electric vehicle's proportion, and the SOC of battery.

  1. Deletion of skeletal muscle SOCS3 prevents insulin resistance in obesity

    DEFF Research Database (Denmark)

    Beck Jørgensen, Sebastian; O'Neill, Hayley M; Sylow, Lykke

    2013-01-01

    Obesity is associated with chronic low-grade inflammation that contributes to defects in energy metabolism and insulin resistance. Suppressor of cytokine signaling (SOCS)-3 expression is increased in skeletal muscle of obese humans. SOCS3 inhibits leptin signaling in the hypothalamus and insulin...... deleted in skeletal muscle (SOCS MKO). The SOCS3 MKO mice had normal muscle development, body mass, adiposity, appetite, and energy expenditure compared with wild-type (WT) littermates. Despite similar degrees of obesity when fed a high-fat diet, SOCS3 MKO mice were protected against the development...... of hyperinsulinemia and insulin resistance because of enhanced skeletal muscle insulin receptor substrate 1 (IRS1) and Akt phosphorylation that resulted in increased skeletal muscle glucose uptake. These data indicate that skeletal muscle SOCS3 does not play a critical role in regulating muscle development or energy...

  2. NIRS as an alternative to conventional soil analysis for Greenland soils (focus on SOC)

    DEFF Research Database (Denmark)

    Knadel, Maria; Ogric, Mateja; Adhikari, Kabindra;

    Soil organic carbon (SOC) is an important soil property. It is the main constituents of soil organic matter and a good indicator of soil quality. The estimation and mapping of SOC content could be used to select potential agricultural areas in the Arctic areas. However, conventional analysis of SOC...... are time consuming and expensive. They involve a lot of sample preparation, and chemicals and are destructive. Near infrared spectroscopy (NIRS) in the range between 400 and 2500 nm is an alternative method for SOC analysis. It is fast and non-destructive. The aims of this study where to test...... the feasibility of using NIRS to estimate SOC content on a landscape and field scale in Greenland. Partial Least squares regression models were built to correlated soil spectra and their reference SOC data to develop calibration models. Very good predictive ability for both landscape and field scale were obtained...

  3. Diseño, construcción y uso de una cámara CCD para observaciones astronómicas

    OpenAIRE

    Roca Molina, Felipe

    2014-01-01

    En este proyecto se presenta la construcción de una cámara CCD (dispositivo de carga acoplada) para su uso posterior en aplicaciones astronómicas siguiendo y adaptando las indicaciones del texto The CCD Camera Cookbook (Berry et al., 1994). Se explica el funcionamiento de una cámara CCD a nivel sencillo particularizada para el chip TC211 de la casa Texas Instuments. Se ha diseñado y construido las placas necesarias y se ha realizado un amplio estudio del funcionamiento de la...

  4. Escuela de literatura i filosofía. programa de jeografía astronómica, física i política

    OpenAIRE

    Pinzón, José Rafael

    2009-01-01

    Nociones preliminares de geometría, necesarias para el estudio de la geografía.Geografía astronómica: Parte histórica; Parte científica; Aspectos del cielo; Estrellas fijas; Distancia de los planetas; Planetas; Planetas superiores; Planetas telescópicos que se encuentran entre Marte y Júpiter: Juno, Céres, Pálas, Vesta; Júpiter y sus satélites; Saturno, sus satélites y anillos; Herschell o Urano y sus satélites; Leverrier o Neptuno; Leyes de Kepler; Atracción universal; Masas planetarias; La ...

  5. El «Plan de las inmediaciones» del Observatorio Astronómico: Un Proyecto desaparecido de Juan de Villanueva

    Directory of Open Access Journals (Sweden)

    Laca Menéndez de Luarca, Luis Ramón

    1999-09-01

    Full Text Available This paper reconstructs the "plan de las inmediaciones" ("project for the surroundings" hypothetically composed by Juan de Villanueva for Madrid Observatorio Astronómico, today disappeared. The data emanated from the drawing dedied to the Observatorio by Isidro Velazquez, Villanueva's best disciple, as well as from the parcel, allow to draw the perfect integration between the building and the surrounding landscape. Because of a number of circumstances two important elements are losten, the original access building and the great 25 feet telescope. Nevertheless, the restoration of the scene conceived by Villanueva, and later drawn by Velazquez, is still perfectly possible.No disponible

  6. Sense of Coherence and Physical Health. A “Copenhagen Interpretation” of Antonovsky's SOC Concept

    Directory of Open Access Journals (Sweden)

    P. Christian Endler

    2008-01-01

    Full Text Available According to Antonovsky's (Aaron Antonovsky, 1923–1994 sense of coherence (SOC model, persons with a high SOC have the ability to benefit from their general defense mechanisms in order to overcome stressful situations. In a health-disease continuum, this leads to the development towards health. However, Antonovsky's global hypothesis that the strength of the SOC may influence the physical health status of a person could not be proven.

  7. Expression of SOCS-1 in the liver tissues of chronic hepatitis B and its clinical significance

    Institute of Scientific and Technical Information of China (English)

    Zhi-Xin Zhao; Qing-Xian Cai; Xiao-Mou Peng; Yu-Tian Chong; Zhi-Liang Gao

    2008-01-01

    AIM: To study the expression of suppressor of cytokine signaling-1 (SOCS-1) in the liver tissues of chronic hepatitis B (CHB) and the clinical significance of this expression.METHODS: The expression of SOCS-1 in liver tissues of 45 cases of CHB was investigated by immunohistochemical staining, and its correlations with inflammation grades and fibrosis stage were analyzed by SPSS statistics software.RESULTS: The result showed SOCS-1 expressing could be observed in the liver tissue of CHB. The expression of SOCS-1 was mainly distributed near the portal area in the liver tissue of mild inflammation CHB group, and was diffusely distributed in the liver tissue of moderate and severe inflammation groups. SOCS-1 positive stains mainly appear in the hepatocytes, only a few of liver interstitial cells were involved. Inside the hepatocyte, SOCS-1 positive stains are mainly distributed in the plasma. Some of the staining was observed on the membrane. The inclusion bodies in the plasma of hepatocytes were observed occasionally. There were both obvious correlations between the expression of SOCS-1 and the inflammatory grade, and that between the expression of SOCS-1 and the fibrosis stage.CONCLUSION: The distribution of SOCS-1 in the liver tissue of CHB is variable. This expression was correlated with the inflammation grade and fibrosis stage.

  8. Promotion of Erythropoietic Differentiation in Hematopoietic Stem Cells by SOCS3 Knock-Down.

    Directory of Open Access Journals (Sweden)

    Yu-xiao Liu

    Full Text Available Suppressor of cytokine signaling 3 (SOCS3 plays an important role in mice fetal liver erythropoiesis, but the roles of SOCS3 in human hematopoietic stem cells (HSCs have not been well investigated. In the present study, lentiviral small interference RNA expression vectors (shRNA of SOCS3 were constructed and stably transferred into HSCs. We found that SOCS3 knockdown induced erythroid expansion in HSCs. Conversely, Ectopic expression of SOCS3 in progenitor cells blocked erythroid expansion and erythroid colony formation of HSCs. To further explore the involved mechanism, we compared gene expression profiles of SOCS3-shRNA tranduced HSCs with that of control HSCs by whole genome microarrays. The results indicated that cell developmental process related genes, especially hematopoietic lineage-specific genes, associated with the responses to SOCS3 in HSCs.Downexpression of SOCS3 in HSCs or differentiated erythroid progenitor cells induced a transcriptional program enriched for erythroid development relative genes. Our results proved that SOCS3 down-expression induced lineage commitment towards erythroid progenitor cell fate by activation of erythroid-specific gene in HSCs and provided new insight into the mechanism of erythropoietic development.

  9. Favorable prognostic value of SOCS2 and IGF-I in breast cancer

    Directory of Open Access Journals (Sweden)

    Daxenbichler Günter

    2007-07-01

    Full Text Available Abstract Background Suppressor of cytokine signaling (SOCS proteins comprise a protein family, which has initially been described as STAT induced inhibitors of the Jak/Stat pathway. Recent in vivo and in vitro studies suggest that SOCS proteins are also implicated in cancer. The STAT5 induced IGF-I acts as an endocrine and para/autocrine growth and differentiation factor in mammary gland development. Whereas high levels of circulating IGF-I have been associated with increased cancer risk, the role of autocrine acting IGF-I is less clear. The present study is aimed to elucidate the clinicopathological features associated with SOCS1, SOCS2, SOCS3, CIS and IGF-I expression in breast cancer. Methods We determined the mRNA expression levels of SOCS1, SOCS2, SOCS3, CIS and IGF-I in 89 primary breast cancers by reverse transcriptase PCR. SOCS2 protein expression was further evaluated by immuno-blot and immunohistochemistry. Results SOCS2 expression inversely correlated with histopathological grade and ER positive tumors exhibited higher SOCS2 levels. Patients with high SOCS2 expression lived significantly longer (108.7 vs. 77.7 months; P = 0.015 and high SOCS2 expression proved to be an independent predictor for good prognosis (HR = 0.45, 95% CI 0.23 – 0.91, P = 0.026. In analogy to SOCS2, high IGF-I expression was an independent predictor for good prognosis in the entire patient cohort. In the subgroup of patients with lymph-node negative disease, high IGF-I was a strong predictor for favorable outcome in terms of overall survival and relapse free survival (HR = 0.075, 95% CI 0.014 – 0.388, P = 0.002. Conclusion This is the first report on the favorable prognostic value of high SOCS2 expression in primary mammary carcinomas. Furthermore a strong association of high IGF-I expression levels with good prognosis was observed especially in lymph-node negative patients. Our results suggest that high expression of the STAT5 target genes SOCS2 and IGF

  10. What are the effects of agricultural management on soil organic carbon (SOC) stocks?

    DEFF Research Database (Denmark)

    Söderström, Bo; Hedlund, Katarina; Jackson, Louise E.

    2014-01-01

    Changes in soil organic carbon (SOC) stocks significantly influence the atmospheric C concentration. Agricultural management practices that increase SOC stocks thus may have profound effects on climate mitigation. Additional benefits include higher soil fertility since increased SOC stocks improve......, such as oxidation/mineralization, leaching and erosion. However, a systematic review comparing the efficacy of different agricultural management practices to increase SOC stocks has not yet been produced. Since there are diverging views on this matter, a systematic review would be timely for framing policies...

  11. IL-10 and socs3 Are Predictive Biomarkers of Dengue Hemorrhagic Fever

    Science.gov (United States)

    Estrada-Jiménez, Tania; Sedeño-Monge, Virginia; Moreno, Margarita; Manjarrez, María del Consuelo; González-Ochoa, Guadalupe; Millán-Pérez Peña, Lourdes

    2017-01-01

    Background Cytokines play important roles in the physiopathology of dengue infection; therefore, the suppressors of cytokine signaling (socs) that control the type and timing of cytokine functions could be involved in the origin of immune alterations in dengue. Objective To explore the association of cytokine and socs levels with disease severity in dengue patients. Methods Blood samples of 48 patients with confirmed dengue infection were analyzed. Amounts of interleukins IL-2, IL-4, IL-6, and IL-10, interferon- (IFN-) γ, and tumor necrosis factor- (TNF-) α were quantified by flow cytometry, and the relative expression of socs1 and socs3 mRNA was quantified by real-time RT-PCR. Results Increased levels of IL-10 and socs3 and lower expression of socs1 were found in patients with dengue hemorrhagic fever (DHF) with respect to those with dengue fever (DF) (p 199.8-fold), socs1 (134 pg/ml) have the highest sensitivity and specificity to discriminate between DF and DHF. Conclusion Simultaneous changes in IL-10 and socs1/socs3 could be used as prognostic biomarkers of dengue severity. PMID:28827898

  12. Model based SOC estimation for high-power Li-ion battery packs used on FCHVs

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    A model based method which recruited the extended Kalman filter (EKF) to estimate the full state of charge (SOC) of Li-ion battery was proposed. The underlying dynamic behavior of the cell pack was described based on an equivalent circuit comprising of two capacitors and three resistors. Measurements in two tests were applied to compare the SOC estimated by model based EKF estimation with the SOC calculated by coulomb counting. Results have shown that the proposed method is able to perform a good estimation of the SOC of battery packs. Moreover, a corresponding battery management systems (BMS) including software and hardware based on this method was designed.

  13. [Effect of reclamation on the vertical distribution of SOC and retention of DOC].

    Science.gov (United States)

    Huo, Li-Li; Zou, Yuan-Chun; Guo, Jia-Wei; Lü, Xian-Guo

    2013-01-01

    Contents and density of soil organic carbon (SOC) in soil profiles and dissolved organic carbon (DOC) of soil solution in different soil depths in wetland, soybean and paddy field reclaimed from the wetland around Xingkai Lake were determined to investigate how reclamation of wetland for soybean and rice farming impacts vertical distribution of SOC and retention of DOC. SOC contents in 0-40 cm soil layers were significantly influenced. SOC contents in 0-10, 10-20, 20-30 and 30-40 cm soil layers in soybean and paddy field were 79.07% and 82.01%, 79.01% and 82.28%, 79.86% and 92.90%, 37.49% and 78.05% respectively lower than those in wetland. Before and after reclamation, SOC contents in soil layers deeper than 40 cm were not significantly different. SOC densities in soybean and paddy field were 25.50% and 47.35% respectively lower than those in wetland. However, either in wetland or farm land, most of the SOC storage in 0-100 cm soil layer was stored in 0-50 cm soil layer. The relationships between SOC content and soil depth in wetland and two farm lands all could be described by exponential functions; cultivation did not change the variation of SOC content with soil depth. The retention of DOC was more obvious for soybean farming than wetland and rice farming, and that was roughly the same for wetland as rice farming.

  14. IL-10 and socs3 Are Predictive Biomarkers of Dengue Hemorrhagic Fever

    Directory of Open Access Journals (Sweden)

    Lilian Karem Flores-Mendoza

    2017-01-01

    Full Text Available Background. Cytokines play important roles in the physiopathology of dengue infection; therefore, the suppressors of cytokine signaling (socs that control the type and timing of cytokine functions could be involved in the origin of immune alterations in dengue. Objective. To explore the association of cytokine and socs levels with disease severity in dengue patients. Methods. Blood samples of 48 patients with confirmed dengue infection were analyzed. Amounts of interleukins IL-2, IL-4, IL-6, and IL-10, interferon- (IFN- γ, and tumor necrosis factor- (TNF- α were quantified by flow cytometry, and the relative expression of socs1 and socs3 mRNA was quantified by real-time RT-PCR. Results. Increased levels of IL-10 and socs3 and lower expression of socs1 were found in patients with dengue hemorrhagic fever (DHF with respect to those with dengue fever (DF (p199.8-fold, socs1 (134 pg/ml have the highest sensitivity and specificity to discriminate between DF and DHF. Conclusion. Simultaneous changes in IL-10 and socs1/socs3 could be used as prognostic biomarkers of dengue severity.

  15. Probing the innermost regions of AGN jets and their magnetic fields with RadioAstron. I. Imaging BL Lacertae at 21 microarcsecond resolution

    CERN Document Server

    Gómez, José L; Bruni, Gabriele; Kovalev, Yuri Y; Marscher, Alan P; Jorstad, Svetlana G; Mizuno, Yosuke; Bach, Uwe; Sokolovsky, Kirill V; Anderson, James M; Galindo, Pablo; Kardashev, Nikolay S; Lisakov, Mikhail M

    2016-01-01

    We present the first polarimetric space VLBI imaging observations at 22 GHz. BL Lacertae was observed in 2013 November 10 with the RadioAstron space VLBI mission, including a ground array of 15 radio telescopes. The instrumental polarization of the space radio telescope is found to be within 9%, demonstrating the polarimetric imaging capabilities of RadioAstron at 22 GHz. Ground-space fringes were obtained up to a projected baseline distance of 7.9 Earth's diameters in length, allowing us to image the jet in BL Lacertae with a maximum angular resolution of 21 $\\mu$as, the highest achieved to date. We find evidence for emission upstream of the radio core, which may correspond to a recollimation shock at about 40 $\\mu$as from the jet apex, in a pattern that includes other recollimation shocks at approximately 100 $\\mu$as and 250 $\\mu$as from the jet apex. Polarized emission is detected in two components within the innermost 0.5 mas from the core, as well as in some knots 3 mas downstream. Faraday rotation analy...

  16. Power optimization and performance improvement for embedded Ethernet SOC

    Institute of Scientific and Technical Information of China (English)

    ZHENG Zhao-xia; ZOU Lian-ying; GAO Jun

    2008-01-01

    Information appliance is the combination of traditional home appliances and the internet technology. In this article, an Ethernet controller system-on-chip (SOC) solution for information appliances is presented. To achieve high performance, the embedded 8 bits 8051 micro control unit (MCU) is optimized by an independent instruction bus and a data bus. Besides, a two-stage pipeline feature is added. Compared with the existing 8051 core, the enhanced one-cycle MCU offers ten times improvement in instruction execution efficiency. Mean- while, the performance of media access control (MAC) circuit is greatly improved by adopting various techniques such as direct memory access (DMA) control, paging strategy, etc. To reduce the power consumption, clock gating, low power supply, and multi-working-clock are adopted. Moreover, to achieve rapid data communication in different clock frequency circuits, a simple ping-pong first in first out (FIFO) circuit is realized. The chip is implemented using TSMC 0.25 μm two-poly four-metal mixed signal complementary metal oxide semiconductor (CMOS) technology. Its die area is mm. The test results show that the maximum throughput of Ethernet packets can reach 7 Mb/s while the power consumption is rather low-the working current is just about 200 mA.

  17. Cache Performance Optimization for SoC Vedio Applications

    Directory of Open Access Journals (Sweden)

    Lei Li

    2014-07-01

    Full Text Available Chip Multiprocessors (CMPs are adopted by industry to deal with the speed limit of the single-processor. But memory access has become the bottleneck of the performance, especially in multimedia applications. In this paper, a set of management policies is proposed to improve the cache performance for a SoC platform of video application. By analyzing the behavior of Vedio Engine, the memory-friendly writeback and efficient prefetch policies are adopted. The experiment platform is simulated by System C with ARM Cotex-A9 processor model. Experimental study shows that the performance can be improved by the proposed mechanism in contrast to the general cache without Last Level Cache (LLC: up to 18.87% Hit Rate increased, 10.62% MM Latency and 46.43% CPU Read Latency decreased for VENC/16way/64bytes; up to 52.1% Hit Rate increased, 11.43% MM Latency and 47.48% CPU Read Latency decreased for VDEC/16way/64bytes, but with only 8.62% and 4.23% Bandwidth increased respectively

  18. SoC Design Approach Using Convertibility Verification

    Directory of Open Access Journals (Sweden)

    Basu Samik

    2008-01-01

    Full Text Available Abstract Compositional design of systems on chip from preverified components helps to achieve shorter design cycles and time to market. However, the design process is affected by the issue of protocol mismatches, where two components fail to communicate with each other due to protocol differences. Convertibility verification, which involves the automatic generation of a converter to facilitate communication between two mismatched components, is a collection of techniques to address protocol mismatches. We present an approach to convertibility verification using module checking. We use Kripke structures to represent protocols and the temporal logic to describe desired system behavior. A tableau-based converter generation algorithm is presented which is shown to be sound and complete. We have developed a prototype implementation of the proposed algorithm and have used it to verify that it can handle many classical protocol mismatch problems along with SoC problems. The initial idea for -based convertibility verification was presented at SLA++P '07 as presented in the work by Roopak Sinha et al. 2008.

  19. Kinase inhibition, competitive binding and proteasomal degradation: resolving the molecular function of the suppressor of cytokine signaling (SOCS) proteins.

    Science.gov (United States)

    Linossi, Edmond M; Nicholson, Sandra E

    2015-07-01

    The suppressor of cytokine signaling (SOCS) family of proteins are key negative regulators of cytokine and growth factor signaling. They act at the receptor complex to modulate the intracellular signaling cascade, preventing excessive signaling and restoring homeostasis. This regulation is critical to the normal cessation of signaling, highlighted by the complex inflammatory phenotypes exhibited by mice deficient in SOCS1 or SOCS3. These two SOCS proteins remain the best characterized of the eight family members (CIS, SOCS1-7), and in particular, we now possess a sound understanding of the mechanism of action for SOCS3. Here, we review the mechanistic role of the SOCS proteins and identify examples where clear, definitive data have been generated and discuss areas where the information is less clear. From this functional viewpoint, we discuss how the SOCS proteins achieve exquisite and specific regulation of cytokine signaling and highlight outstanding questions regarding the function of the less well-studied SOCS family members.

  20. Synthesis of highly monodispersed Ga-soc-MOF hollow cubes, colloidosomes and nanocomposites

    KAUST Repository

    Cai, Xuechao

    2016-07-06

    Ga-soc-MOF hollow cubes with an average size of about 300 nm were prepared by a polyvinylpyrrolidone (PVP) assisted acid etching process. Colloidosomes with sizes of around 5-10 mu m composed of single-layer tetrakaidecahedron building blocks (BBs) were synthesized for the first time. Au@Ga-soc-MOF nanocomposites with excellent catalytic properties were obtained.

  1. Boosted gain programmable OpAmp with embedded gain monitor for dependable SoCs

    NARCIS (Netherlands)

    Wan, Jinbo; Kerkhoff, Hans G.

    2011-01-01

    SoCs used in safety-critical applications need to be dependable. However in the deep-submicron region, different kinds of aging effects like negative bias temperature instability (NBTI) make the SoCs, especially the analog/mixed-signal parts, undependable. In this paper, a dependability-improved Opa

  2. A Technique for Accelerating Injection of Transient Faults in Complex SoCs

    NARCIS (Netherlands)

    Rohani, A.; Kerkhoff, Hans G.

    2011-01-01

    This paper presents a technique for reducing CPU time to perform simulation-based fault-injection experiments in complex SoCs. This technique is fully compatible with commercial HDL simulators with no requirement to develop dedicated compilers. This approach can be easily applied to complex SoC moel

  3. Predicted soil management and climate change effects on SOC in South Carolina

    Science.gov (United States)

    Extensive use of inversion tillage has contributed to the loss of soil organic carbon (SOC) and degraded soil health in the southeast U.S.A. Our objective was to predict changes in SOC in a Norfolk loamy sand in Florence, SC under several crop rotations (corn (Zea mays L.)-cotton (Gossypium ssp.), C...

  4. Role of Leptin and SOCS3 in Inhibiting the Type I Interferon Response During Obesity.

    Science.gov (United States)

    Terán-Cabanillas, Elí; Hernández, Jesús

    2017-02-01

    Obesity provokes an imbalance in the immune system, including an aberrant type I interferon response during some viral infections and after TLR stimulation. SOCS3 overexpression and altered systemic leptin levels could be responsible for the reduced type I interferon production in people with obesity and, eventually, significantly increase the risk of viral infection. The aim of this study was to determine whether SOCS3- and leptin-induced tolerance are responsible for the reduced type I interferon production in people with obesity. SOCS3 overexpression in PBMCs from people with obesity was inhibited with the small interfering RNA (siRNA) assay, and leptin-induced tolerance was evaluated in PBMCs from non-obese volunte\\ers and U937 cells treated with TLR ligands. SOCS3, but not SOCS1, gene silencing via siRNA increased the type I interferon response in PBMCs obtained from people with obesity. On the other hand, leptin induced SOCS3 expression and inhibited type I interferons in PBMCs from healthy donors and in U937 monocytes stimulated with TLR ligands. Taken together, these results demonstrate that reduced type I interferon production in obesity is caused by SOCS3 overexpression as well as tolerance induced by leptin. Here, we demonstrate a key role of leptin and SOCS3 in inhibiting the type I interferon response during obesity.

  5. Sense of coherence and physical health. A "Copenhagen interpretation" of Antonovsky's SOC concept.

    Science.gov (United States)

    Endler, P Christian; Haug, Thomas M; Spranger, Heinz

    2008-04-20

    According to Antonovsky's (Aaron Antonovsky, 1923-1994) sense of coherence (SOC) model, persons with a high SOC have the ability to benefit from their general defense mechanisms in order to overcome stressful situations. In a health-disease continuum, this leads to the development towards health. However, Antonovsky's global hypothesis that the strength of the SOC may influence the physical health status of a person could not be proven. Flensborg-Madsen et al. from Copenhagen were able to provide a new access regarding SOC and health. They investigated the mixture of emotional aspects and mental constructions as a possible cause for fairly low correlation between SOC and physical health. Thus, in an empirical way, they described "emotional coherence" in relation to physical health, while "mental coherence" was linked to psychological health. These authors introduced the idea of applying a shortened version of the original 29-item SOC questionnaire, but have not yet developed or tested the shortened questionnaire. Backed by their important findings, it appears to be promising to consider the use of the SOC questionnaire as standardized by Antonovsky, but cleared of the items regarding "predictability", i.e., Flensborg-Madsen et al. suggested that the items on "predictability" be excluded from the SOC scale when a correlation to physical health is to be investigated. Further investigations in this area of research will be of high impact, not only for health sciences, but also for medical practice.

  6. The 2010 Standard Occupational Classification (SOC): A Classification System Gets an Update

    Science.gov (United States)

    Emmel, Alissa; Cosca, Theresa

    2010-01-01

    Making sense of occupational data isn't always easy. But the task is less daunting when the data are well organized. For Federal occupational statistics, the Standard Occupational Classification (SOC) system establishes that organization. And a recent revision to the SOC means that the data will be current, in addition to being well organized. The…

  7. Synthesis of highly monodispersed Ga-soc-MOF hollow cubes, colloidosomes and nanocomposites.

    Science.gov (United States)

    Cai, Xuechao; Deng, Xiaoran; Xie, Zhongxi; Bao, Shouxin; Shi, Yanshu; Lin, Jun; Pang, Maolin; Eddaoudi, Mohamed

    2016-08-02

    Ga-soc-MOF hollow cubes with an average size of about 300 nm were prepared by a polyvinylpyrrolidone (PVP) assisted acid etching process. Colloidosomes with sizes of around 5-10 μm composed of single-layer tetrakaidecahedron building blocks (BBs) were synthesized for the first time. Au@Ga-soc-MOF nanocomposites with excellent catalytic properties were obtained.

  8. A MGy Radiation-Hardened Sensor Instrumentation SoC in 65nm CMOS Technology

    OpenAIRE

    Verbeeck, Jens; Cao, Ying; Van Uffelen, Marco; Mont Casellas, Laura; Damiani, Carlo; Meek, Richard; Haist, Bernhard; Steyaert, Michiel; Leroux, Paul

    2014-01-01

    A radiation-hardened sensor instrumentation SoC is presented in this paper. The SoC is implemented in a standard 65nm CMOS technology, and achieves MGy-level TID radiation hardness through radiation-hardening-by-design.

  9. SOC EKF Estimation based on a Second-order LiFePO4 Battery Model

    Directory of Open Access Journals (Sweden)

    Zheng Zhu

    2013-08-01

    Full Text Available An accurate battery State of Charge (SOC estimation has great significance in improving battery life and vehicle performance. An improved second-order battery model is proposed in this paper through quantities of LiFePO4 battery experiments. The parameters of the model were acquired by the HPPC composite pulse condition under different temperature, charging and discharging rates, SOC. Based on the model, battery SOC is estimated by Extended Kalman Filter (EKF. Comparison of three different pulse conditions shows that the average error of SOC estimation of this algorithm is about 4.2%. The improved model is able to reflect the dynamic performance of batteries suitably, and the SOC estimation algorithm is provided with higher accuracy and better dynamic adaptability.

  10. SOC Estimation of LiFePO4 Battery based on Improved Ah Integral Method

    Directory of Open Access Journals (Sweden)

    Zheng ZHU

    2013-07-01

    Full Text Available State of charge (SOC is the most important status parameters of energy storage system, which is able to predict the available mileage of electric vehicle. In fact, the accuracy of SOC estimation plays a vital role in the usability and security of the battery. To fully consider the practical demands, a novel method to predict SOC of LiFePO4 battery is presented in this paper, which defines the correct coefficient separately under two working conditions of charging and discharging. Based on effective factors such as coulombic efficiency, charge and discharge current, and temperature, an Ah integral SOC estimation method with two kinds of efficiency correct coefficients is established by performing massive experimental study. Experiments prove that the estimated error of SOC is less than 5%. Compared with the original Ah method, the improved Ah method is more advantageous in the accuracy and reliability.

  11. Research on SOC estimation based on second-order RC model

    Directory of Open Access Journals (Sweden)

    Xieyang Wang

    2012-11-01

    Full Text Available The estimation accuracy of batteries’ State of Charge (SOC plays an important role in the development of hybrid electric vehicle (HEV. Accurate estimation of SOC can prevent battery from overly charging and discharging, so the lifetime of batteries will be increased. Although Kalman filter algorithm has better estimation accuracy for HEV application in which the current changes fast, Kalman filter algorithm deeply relies on the battery model. In other words, the accuracy of batteries’ SOC estimation needs precise batteries models. Besides, when the HEV is running, the statistical characteristics of noise produced in the course of the battery management system collecting data are unknown. This can cause estimated performance of Kalman filter algorithm to decrease even diffuse. To solve the problem, adaptive Kalman filter algorithm is adopted to estimate battery SOC based on the second order RC battery model in this paper. Through MATLAB simulation analysis, the estimation accuracy of battery SOC is improved to some extent.

  12. STAT3-mediated constitutive expression of SOCS-3 in cutaneous T-cell lymphoma

    DEFF Research Database (Denmark)

    Brender, C; Nielsen, M; Kaltoft, K;

    2001-01-01

    A characteristic feature of neoplastic transformation is the loss of external control by cytokines and extracellular matrix of cellular differentiation, migration, and mitogenesis. Because suppressors of cytokine signaling (SOCS) proteins are negative regulators of cytokine-induced signaling......, it has been hypothesized that an aberrant SOCS expression plays a role in neoplastic transformation. This study reports on a constitutive SOCS-3 expression in cutaneous T-cell lymphoma (CTCL) cell lines. SOCS-3 protein is constitutively expressed in tumor cell lines (but not in nonmalignant T cells......) obtained from affected skin from a patient with mycosis fungoides (MF) and from peripheral blood from a patient with Sezary syndrome (SS). In contrast, constitutive SOCS-3 expression is not found in the leukemic Jurkat T-cell line, the MOLT-4 acute lymphoblastic leukemia cell line, and the monocytic...

  13. Immature B Cell Egress from Bone Marrow Is SOCS3 Independent.

    Directory of Open Access Journals (Sweden)

    Kristina Nadrah

    Full Text Available Suppressor of cytokine signaling (SOCS-3 has been suggested to regulate CXCR4 signaling in a variety of human cell lines. In mice, conditional SOCS3 inactivation in hematopoietic cells including B-lineage lymphocytes has been reported to exacerbate CXCR4-signaling and focal adhesion kinase phosphorylation, which resulted in altered immature B cell distribution in bone marrow (BM due to sustained α4β1 integrin-mediated adhesion to the extracellular matrix. However, a recent study examining conditional SOCS3 deletion specifically in B-lineage cells failed to detect significant roles in B-lineage cell retention in BM. In this study we carefully examined the role played by SOCS3 in CXCR4 signaling in developing B cell subsets. We show that in mice conditionally deficient in SOCS3 exclusively in B cells (Socs3fl/fl Mb1cre/+ there was no detectable difference in B cell development in BM and in periphery. We show that SOCS3 deficient and sufficient immature B cell subsets are similarly distributed between BM parenchyma and sinusoids, and are equally competent at exiting BM into peripheral blood. Furthermore, we found no significant differences in CXCR4 desensitization upon ligand exposure in developing B lymphocyte subsets. Consequently, SOCS3-deficient and sufficient B-lineage cell migration towards CXCL12 in vitro was undistinguishable, and B-lineage cell amoeboid motility within BM parenchyma was also unaffected by SOCS3-deficiency. Thus we conclude that SOCS3 has no detectable influence on biological processes known to be controlled by CXCR4 signaling.

  14. The Prognostic Role of SOCS3 and A20 in Human Cholangiocarcinoma.

    Directory of Open Access Journals (Sweden)

    Yimin Wang

    Full Text Available As an antagonist of the JAK/STAT pathway, suppressor of cytokine signaling 3 (SOCS3 plays an integral role in shaping the inflammatory environment, tumorigenesis and disease progression in cholangiocarcinoma (CCA; however, its prognostic significance remains unclear. Although tumor necrosis factor α-induced protein 3 (TNFAIP3, also known as A20 can decrease SOCS3 expression and is involved in the regulation of tumorigenesis in certain malignancies, its role in CCA remains unknown. In this study, we investigated the expression of SOCS3 and A20 in human CCA tissues to assess the prognostic significance of these proteins. The expression of SOCS3 and A20 was initially detected by western blot in 22 cases of freshly frozen CCA tumors with corresponding peritumoral tissues and 22 control normal bile duct tissues. Then, these proteins were investigated in 86 CCA patients by immunohistochemistry (IHC and were evaluated for their association with clinicopathological parameters in human CCA. The results indicated that SOCS3 expression was significantly lower in CCA tumor tissues than in corresponding peritumoral biliary tissues and normal bile duct tissues. Conversely, A20 was overexpressed in CCA tissues. Thus, an inverse correlation between the expression of SOCS3 and A20 was discovered. Furthermore, patients with low SOCS3 expression or high A20 expression showed a dramatically lower overall survival rate. These proteins were both associated with CCA lymph node metastasis, postoperative recurrence and overall survival rate. However, only A20 showed a significant association with the tumor node metastasis (TNM stage, while SOCS3 showed a significant association with tumor differentiation. Multivariate Cox analysis revealed that SOCS3 and A20 were independent prognostic indicators for overall survival in CCA. Thus, our study demonstrated that SOCS3 and A20 represent novel prognostic factors for human CCA.

  15. Sense of coherence and physical health. A cross-sectional study using a new scale (SOC II).

    Science.gov (United States)

    Flensborg-Madsen, Trine; Ventegodt, Søren; Merrick, Joav

    2006-10-09

    In this study, we constructed a new sense of coherence scale (SOC II), where we eliminated the notion of predictability (that life is meant to be predictable), which was present in the original SOC scale developed by Aaron Antonovsky (1923-1994) (SOC-29 and SOC-13). Our hypothesis was that SOC II would show a higher degree of association with physical health than the original SOC scale. In order to test this idea, we used a cross-sectional study including 4,648 Danes and used the three different health measures: self-evaluated physical health, physical symptoms, and self-evaluated psychological health. We found that SOC II was positively associated with all three health measures with the correlation coefficients 0.338, 0.282, and 0.578, respectively. Furthermore, we found dose response tendencies for all three health measures across groups of SOC, since health improved with a higher SOC. By means of regression analysis, we found that SOC was significantly associated with all three health measures after stratifying for demographic variables, life style variables, life form variables, and attitude variables, respectively. We conclude from this study that the SOC II scale we developed seems better associated with physical health than found with the original SOC scale. We also postulate that the concept of predictability was irrelevant, or even disturbing, and should not be included in the SOC scale.

  16. Stress coping ability in nursing students: studies on the influence factor of Sense of Coherence (SOC).

    Science.gov (United States)

    Okumura, Ryusaku; Suzuki, Tamami; Bai, Yoshiko; Mukawa, Kazuma

    2012-07-01

    The researchers conducted an investigation on factors influencing stress coping ability, referred to as a Sense of Coherence (SOC). 278 students in the 2nd to 4th year of "A" University nursing program were subjected to this survey, and the response rate was 75.5%. The average SOC value was 39.5 +/- 6.6 for males, and 37.4 +/- 7.0 for females. The value for age group 20 to 24 years old was 37.1 +/- 6.8. The average SOC value obtained through this survey was higher than the survey results of the Kanto region and lower than the national results. When a comparison was made between "the group with higher average SOC" and "the group with lower average SOC" among the entire survey average SOC, especially significant differences were discovered in the following items. "Prospects for the future is bright", "Difficult experiences have meaning", "I have good relationship with friends", "I feel stressed", and "I was seriously ill" (P SOC.

  17. Suppressor of cytokine signaling (SOCS genes are silenced by DNA hypermethylation and histone deacetylation and regulate response to radiotherapy in cervical cancer cells.

    Directory of Open Access Journals (Sweden)

    Moon-Hong Kim

    Full Text Available Suppressor of cytokine signaling (SOCS family is an important negative regulator of cytokine signaling and deregulation of SOCS has been involved in many types of cancer. All cervical cancer cell lines tested showed lower expression of SOCS1, SOCS3, and SOCS5 than normal tissue or cell lines. The immunohistochemistry result for SOCS proteins in human cervical tissue also confirmed that normal tissue expressed higher level of SOCS proteins than neighboring tumor. Similar to the regulation of SOCS in other types of cancer, DNA methylation contributed to SOCS1 downregulation in CaSki, ME-180, and HeLa cells. However, the expression of SOCS3 or SOCS5 was not recovered by the inhibition of DNA methylation. Histone deacetylation may be another regulatory mechanism involved in SOCS1 and SOCS3 expression, however, SOCS5 expression was neither affected by DNA methylation nor histone deacetylation. Ectopic expression of SOCS1 or SOCS3 conferred radioresistance to HeLa cells, which implied SOCS signaling regulates the response to radiation in cervical cancer. In this study, we have shown that SOCS expression repressed by, in part, epigenetically and altered SOCS1 and SOCS3 expression could contribute to the radiosensitive phenotype in cervical cancer.

  18. Percepção Astronômica de Alunos do Ensino Médio da Rede Estadual de São Paulo

    Science.gov (United States)

    de Oliveira, E. F.; Voelzke, M. R.; Amaral, L. H.

    2005-08-01

    Embora a astronomia seja uma das ciências mais antigas da humanidade e muitos dos conceitos astronômicos serem populares, principalmente nesta época de alta globalização do conhecimento por intermédio de eficientes meios de comunicação e de obtenção da informação, notadamente através da internet, observa-se que uma parcela significativa dos estudantes encontra-se à margem dessas informações. O presente trabalho visa analisar o nível de conhecimento básico dos alunos de Ensino Médio da rede estadual da cidade de Suzano quanto aos fenômenos astronômicos que os rodeiam, tais como a sucessão dos dias e das estações do ano, além de questioná-los sobre fatos genéricos tais como: quais são os astros que se encontram mais próximos do planeta Terra, o que vem a ser o Sol, o Big Bang, um ano-luz, uma estrela cadente, a estrela de Bélem e o que ocasionou a extinção dos dinossauros. Para tanto foi elaborado um formulário constando de questões de múltipla escolha, o qual foi aplicado no primeiro colegial noturno da Escola Estadual Batista Renzi. Num espaço amostral de 34 alunos constatou-se que apenas 29,4% compreendiam a sucessão dos dias da semana, que apenas 20,6% explicaram corretamente as estações do ano, que apenas 20,6% tinham idéia de quais são os objetos celestes mais próximos da Terra, em contraposição 67,6% sabiam classificar corretamente o Sol como estrela, 55,9% relacionavam o Big Bang à origem do universo, apenas 20,6% identificavam um ano-luz como unidade de distância, 32,4% reconheciam uma estrela cadente como meteoro, 41,2% consideravam a estrela de Belém como um cometa e 50,0% explicaram corretamente a extinção dos dinossauros. A presente análise será expandida para as demais classes de primeiro colegial, não somente do período noturno, mas também do diurno da Escola Estadual Batista Renzi, bem como o formulário será devidamente ampliado. Já nesta primeira fase nota-se claramente o pequeno discernimento

  19. The Fabra-ROA Baker-Nunn Camera at Observatori Astron\\`omic del Montsec: a wide-field imaging facility for exoplanet transit detection

    CERN Document Server

    Fors, O; Muiños, J L; Montojo, F J; Baena, R; Merino, M; Morcillo, R; Blanco, V

    2009-01-01

    A number of Baker-Nunn Camera (BNC) were manufactured by Smithsonian Institution during the 60s as optical tracking systems for artificial satellites with optimal optical and mechanical specifications. One of them was installed at the Real Instituto y Observatorio de la Armada (ROA). We have conducted a profound refurbishment project of the telescope to be installed at Observatori Astron\\`omic del Montsec (OAdM). As a result, the BNC offers the largest combination of a huge FOV (4.4$\\deg$x4.4$\\deg$) and aperture (leading to a limiting magnitude of V$\\sim$20). These specifications, together with their remote and robotic natures, allows this instrument to face an observational program of exoplanets detection by means of transit technique with high signal-to-noise ratio in the appropiate magnitude range.

  20. A Influência da Escola e da Mídia na Obtenção dos Conhecimentos Astronômicos

    Science.gov (United States)

    da Cunha, W. S.; Voelzke, M. R.; Amaral, L. H.

    2006-08-01

    O universo em que vivemos possui segredos jamais imaginados pelo homem, fruto da pequena proporção que ocupamos diante de um cosmos infinito. A astronomia funciona como um instrumento que sacia a sede humana em desvendar esses segredos, estudando as galáxias, quasares, pulsares além da existência de todos os elementos que preenchem o espaço cósmico, o vácuo, não mais vazio como se pensou em outros tempos. A mídia explora esse campo de forma mística e também científica. A difusão adequada e dentro dos padrões educacionais vigentes, de conceitos astronômicos, se faz necessária, devido sua presença nos conteúdos escolares, centros de ciência e na mídia, de modo geral. A reforma do Currículo Básico da Escola Pública da maioria dos Estados brasileiros introduziu conceitos astronômicos desde a pré-escola até o Ensino Médio. Num estudo realizado com 1.032 alunos do Ensino Médio de seis escolas estaduais, revelou-se através da aplicação de um questionário que abordava conheciment os básicos em astronomia, como estes foram adquiridos e qual era a infra-estrutura oferecida pela escola: para 66,2% dos entrevistados o professor já fez alguma apresentação a respeito de astronomia. O presente estudo revelou também que 44,5% dos alunos entrevistados adquiriram seus conhecimentos astronômicos na escola, 28,1% através da televisão e 27,4% afirmaram que seus conhecimentos foram obtidos através de outros tipos de mídia (internet, filmes e revistas). Embora o estudo revele claramente que há certo equilíbrio na forma em que os alunos obtiveram seus conhecimentos astronômicos, a mídia ainda explora e muitas vezes desperta o interesse pela astronomia com assuntos que não fazem parte de nosso cotidiano como, por exemplo, o homem na Lua, os projetos espaciais e a primeira viagem de um astronauta brasileiro no espaço. Porém, em certos casos, a mídia pode promover conhecimentos incompletos ou mesmo equivocados sobre os conceitos que envolvam

  1. Supuestos y filiaciones filosóficas de los paradigmas astronómicos en el virreinato del Perú

    Directory of Open Access Journals (Sweden)

    Roberto Katayama Omura

    2014-03-01

    Full Text Available En el presente artículo se estudian los supuestos y filiaciones filosófico-naturales de los paradigmas astronómicos vigentes en el virreinato delPerú. Se busca demostrar que hasta el siglo XVIII fue dominante el paradigma clásico o geocéntrico en la versión moderna de Tycho Brahe y quetambién estuvo presente el paradigma clásico en su versión tradicionalo ptolemaica aunque con menos fuerza. Finalmente, se propone quedesde mediados del siglo XVIII se introduce en el virreinato peruano elparadigma moderno kepleriano-newtoniano el cual se impondrá a finesdel mismo siglo.

  2. The adaptor protein soc-1/Gab1 modifies growth factor receptor output in Caenorhabditis elegans.

    Science.gov (United States)

    Hopper, Neil A

    2006-05-01

    Previous genetic analysis has shown that dos/soc-1/Gab1 functions positively in receptor tyrosine kinase (RTK)-stimulated Ras/Map kinase signaling through the recruitment of csw/ptp-2/Shp2. Using sensitized assays in Caenorhabditis elegans for let-23/Egfr and daf-2/InsR (insulin receptor-like) signaling, it is shown that soc-1/Gab1 inhibits phospholipase C-gamma (PLCgamma) and phosphatidylinositol 3'-kinase (PI3K)-mediated signaling. Furthermore, as well as stimulating Ras/Map kinase signaling, soc-1/Gab1 stimulates a poorly defined signaling pathway that represses class 2 daf-2 phenotypes. In addition, it is shown that SOC-1 binds the C-terminal SH3 domain of SEM-5. This binding is likely to be functional as the sem-5(n2195)G201R mutation, which disrupts SOC-1 binding, behaves in a qualitatively similar manner to a soc-1 null allele in all assays for let-23/Egfr and daf-2/InsR signaling that were examined. Further genetic analysis suggests that ptp-2/Shp2 mediates the negative function of soc-1/Gab1 in PI3K-mediated signaling, as well as the positive function in Ras/Map kinase signaling. Other effectors of soc-1/Gab1 are likely to inhibit PLCgamma-mediated signaling and stimulate the poorly defined signaling pathway that represses class 2 daf-2 phenotypes. Thus, the recruitment of soc-1/Gab1, and its effectors, into the RTK-signaling complex modifies the cellular response by enhancing Ras/Map kinase signaling while inhibiting PI3K and PLCgamma-mediated signaling.

  3. Mobile 3D Graphics SoC From Algorithm to Chip

    CERN Document Server

    Woo, Jeong-Ho; Nam, Byeong-Gyu

    2010-01-01

    The first book to explain the principals behind mobile 3D hardware implementation, helping readers understand advanced algorithms, produce low-cost, low-power SoCs, or become familiar with embedded systems. As mobile broadcasting and entertainment applications evolve, there is increasing interest in 3D graphics within the field of mobile electronics, particularly for handheld devices. In Mobile 3D Graphics SoC , Yoo provides a comprehensive understanding of the algorithms of mobile 3D graphics and their real chip implementation methods. 3D graphics SoC (System on a Chip) architecture and its i

  4. Test access to deeply embedded analog terminals within an A/MS SoC

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    This paper presents a standard scalable and reconfigurable design for testability (SR DfT) in order to increase accessibility to deeply embedded A/MS cores and to limit application of costly off-chip mixed-signal testers. SR DfT is an oscillation-based wrapper compatible with digital embedded core-based SoC test methodologies. The impact of the optimized oscillation-based wrapper design on MS SoC testing is evaluated in two directions: area and test time. Experimental results are presented for several SoCs from the ITC'02 test benchmarks with inclusion of eight analog filters.

  5. SOCS2 deletion protects against hepatic steatosis but worsens insulin resistance in high-fat-diet-fed mice

    DEFF Research Database (Denmark)

    Zadjali, Fahad; Santana-Farre, Ruyman; Vesterlund, Mattias

    2012-01-01

    in the development of diet-induced hepatic steatosis and insulin resistance. SOCS2-knockout (SOCS2(-/-)) mice and wild-type littermates were fed for 4 mo with control or high-fat diet, followed by assessment of insulin sensitivity, hepatic lipid content, and expression of inflammatory cytokines. SOCS2(-/-) mice...

  6. Biological evidence that SOCS-2 can act either as an enhancer or suppressor of growth hormone signaling

    DEFF Research Database (Denmark)

    Greenhalgh, Christopher J; Metcalf, Donald; Thaus, Anne L

    2002-01-01

    Suppressor of cytokine signaling (SOCS)-2 is a member of a family of intracellular proteins implicated in the negative regulation of cytokine signaling. The generation of SOCS-2-deficient mice, which grow to one and a half times the size of their wild-type littermates, suggests that SOCS-2 may at...

  7. Growth hormone preferentially induces the rapid, transient expression of SOCS-3, a novel inhibitor of cytokine receptor signaling

    DEFF Research Database (Denmark)

    Adams, T E; Hansen, J A; Starr, R;

    1998-01-01

    Four members (SOCS-1, SOCS-2, SOCS-3, and CIS) of a family of cytokine-inducible, negative regulators of cytokine receptor signaling have recently been identified. To address whether any of these genes are induced in response to growth hormone (GH), serum-starved 3T3-F442A fibroblasts were...

  8. Effects of Reducing Suppressors of Cytokine Signaling-3 (SOCS3 Expression on Dendritic Outgrowth and Demyelination after Spinal Cord Injury.

    Directory of Open Access Journals (Sweden)

    Keun Woo Park

    Full Text Available Suppressors of cytokine signaling-3 (SOCS3 is associated with limitations of nerve growth capacity after injury to the central nervous system. Although genetic manipulations of SOCS3 can enhance axonal regeneration after optic injury, the role of SOCS3 in dendritic outgrowth after spinal cord injury (SCI is still unclear. The present study investigated the endogenous expression of SOCS3 and its role in regulating neurite outgrowth in vitro. Interleukin-6 (IL-6 induces SOCS3 expression at the mRNA and protein levels in neuroscreen-1 (NS-1 cells. In parallel to SOCS3 expression, IL-6 induced tyrosine phosphorylation of signal transducer and activator of transcription 3 (STAT3 in NS-1 cells. Lentiviral delivery of short hairpin RNA (shSOCS3 (Lenti-shSOCS3 to decrease SOCS3 expression into NS-1 cells enhanced IL-6-induced tyrosine phosphorylation of STAT3 (P-STAT3 Tyr705 and promoted neurite outgrowth. In addition, we determined if reduction of SOCS3 expression by microinjection of Lenti-shSOCS3 into spinal cord enhances dendrite outgrowth in spinal cord neurons after SCI. Knocking down of SOCS3 in spinal cord neurons with Lenti-shSOCS3 increased complete SCI-induced P-STAT3 Tyr705. Immunohistochemical analysis showed that complete SCI induced a significant reduction of microtubule association protein 2-positive (MAP-2+ dendrites in the gray and white matter at 1 and 4 weeks after injury. The SCI-induced reduction of MAP-2+ dendrites was inhibited by infection with Lenti-shSOCS3 in areas both rostral and caudal to the lesion at 1 and 4 weeks after complete SCI. Furthermore, shSOCS3 treatment enhanced up-regulation of growth associated protein-43 (GAP-43 expression, which co-localized with MAP-2+ dendrites in white matter and with MAP-2+ cell bodies in gray matter, indicating Lenti-shSOCS3 may induce dendritic regeneration after SCI. Moreover, we demonstrated that Lenti-shSOCS3 decreased SCI-induced demyelination in white matter of spinal cord both

  9. Insulin resistance, adipokine profile and hepatic expression of SOCS-3 gene in chronic hepatitis C

    OpenAIRE

    Wójcik, Kamila; Jabłonowska, Elżbieta; Omulecka, Aleksandra; Piekarska, Anna

    2014-01-01

    AIM: To analyze adipokine concentrations, insulin resistance and hepatic expression of suppressor of cytokine signaling 3 (SOCS-3) in patients with chronic hepatitis C genotype 1 with normal body weight, glucose and lipid profile.

  10. Mapping SOC in a river catchment by integrating laboratory spectra wavelength with remote sensing spectra

    DEFF Research Database (Denmark)

    Peng, Yi; Xiong, Xiong; Knadel, Maria;

    There is potential to use soil ·-proximal and remote sensing derived spectra concomitantly to develop soil organic carbon (SOC) models. Yet mixing spectral data from different sources and technologies to improve soil models is still in its infancy. The objective of this study was to incorporate...... soil spectral features indicative of SOC from laboratory visible near-infrared reflectance (vis-NlR) spectra and incorporate them with remote sensing (RS) images to improve predictions of top SOC in the Skjem river catchment, Denmark. The secondary objective was to improve prediction results...... by separately calibrating samples from upland and wetland. We hypbthesize that final prediction accuracy is significantly improved by incorporatin1 laboratory vis-NlR images upscaled from point-based spectra to catchment scale and RS data for topsoil SOC spatial modeling....

  11. Comparison Study on the Battery SoC Estimation with EKF and UKF Algorithms

    Directory of Open Access Journals (Sweden)

    Hongwen He

    2013-09-01

    Full Text Available The battery state of charge (SoC, whose estimation is one of the basic functions of battery management system (BMS, is a vital input parameter in the energy management and power distribution control of electric vehicles (EVs. In this paper, two methods based on an extended Kalman filter (EKF and unscented Kalman filter (UKF, respectively, are proposed to estimate the SoC of a lithium-ion battery used in EVs. The lithium-ion battery is modeled with the Thevenin model and the model parameters are identified based on experimental data and validated with the Beijing Driving Cycle. Then space equations used for SoC estimation are established. The SoC estimation results with EKF and UKF are compared in aspects of accuracy and convergence. It is concluded that the two algorithms both perform well, while the UKF algorithm is much better with a faster convergence ability and a higher accuracy.

  12. The effect of synchronized area on SOC behavior in a kind of Neural Network Model

    OpenAIRE

    Zhao, Xiao Wei; Chen, Tian Lun

    2000-01-01

    Based on the LISSOM model and the OFC earthquake model, we introduce a self-organized feature map Neural Network model . It displays a "Self Organized Criticality"(SOC) behavior. It can be seen that the feature area (synchronized area) produced by self-organized process brings about some definite effect on SOC behavior and the system evolves into a "partly-synchronized" state. For explaining this phenomena, a quasi-OFC earthquake model is simulated.

  13. The inventory-based approach for prediction of SOC change following land use change

    Directory of Open Access Journals (Sweden)

    van Wesemael B.

    2004-01-01

    Full Text Available This paper describes and illustrates an approach to predict soil organic carbon (SOC change in time after land use change as derived from SOC differences in space. The approach requires the availability of a SOC inventory for spatially explicit combinations of soil and land use type, further termed landscape units (LSU. SOC of LSU with equal soil type but different land use type are compared and the observed differences in SOC are interpreted as the expected SOC change after the corresponding land use change. From a confrontation with time series of agro-statistical data on crop and grassland areas and on animal manure production, we conclude that the approach is a low-cost alternative for more complex methods like multitemporal assessments and modelling, provided that (i an inventory reflecting current management and climate conditions and (ii additional information on the extent and type of recent land use changes are available. Examples of land use and land management changes are discussed, such as grassland – cropland conversions, the conversion of permanent to temporary grassland, or changes in manure application.

  14. Optimal hardware/software co-synthesis for core-based SoC designs

    Institute of Scientific and Technical Information of China (English)

    Zhan Jinyu; Xiong Guangze

    2006-01-01

    A hardware/software co-synthesis method is presented for SoC designs consisting of both hardware IP cores and software components on a graph-theoretic formulation. Given a SoC integrated with a set of functions and a set of performance factors, a core for each function is selected from a set of alternative IP cores and software components, and optimal partitions is found in a way to evenly balance the performance factors and to ultimately reduce the overall cost, size, power consumption and runtime of the core-based SoC. The algorithm formulates IP cores and components into the corresponding mathematical models, presents a graph-theoretic model for finding the optimal partitions of SoC design and transforms SoC hardware/software co-synthesis problem into finding optimal paths in a weighted, directed graph. Overcoming the three main deficiencies of the traditional methods, this method can work automatically, evaluate more performance factors at the same time and meet the particularity of SoC designs.At last, the approach is illustrated that is practical and effective through partitioning a practical system.

  15. Antonovsky's Sense of Coherence Scale: Cultural Validation of Soc Questionnaire and Socio-Demographic Patterns in an Italian Population.

    Science.gov (United States)

    Sardu, Claudia; Mereu, Alessandra; Sotgiu, Alessandra; Andrissi, Laura; Jacobson, Maria Katarina; Contu, Paolo

    2012-01-01

    The theory of salutogenesis entails that the ability to use resources for one's wellbeing is more important than the resources themselves. This ability is referred to as the Sense of Coherence (SOC). This paper present the cross-culturally adapted version of the Italian questionnaire (13 items), and the psychometric and statistical testing of the SOC properties. It offers for the first time a view of the distribution of SOC in an Italian sample, and uses a multivariate method to clarify the effects of socio-demographic determinants on SOC. The cross-cultural adaptation of the English SOC questionnaire was carried out according to the guidelines reported in literature. To evaluate the psychometric and statistical properties we assessed reliability, validity and frequency distribution of the collected data. A Generalised Linear Model was used to analyse the effects of socio demographic variables on SOC. The Italian SOC scale demonstrates a good internal consistency (α = 0.825). The model obtained with factorial analysis is not related to the traditional dimensions of SOC represented in more than one factor. The multivariate analysis highlights the joint influence of gender, age and education on SOC. The validated Italian questionnaire is now available. Socio-demographic variables should be taken into account as confounders when SOC values among different populations are compared. Presenting data on SOC of the Italian population makes a control population available for comparisons with specific subgroups, such as patient populations. Now, the Italian challenge is to integrate the salutogenic approach into Public Health police.

  16. The suppressor of cytokine signaling SOCS1 promotes apoptosis of intestinal epithelial cells via p53 signaling in Crohn's disease.

    Science.gov (United States)

    Cui, Xiaopeng; Shan, Xiaohang; Qian, Ji; Ji, Qianqian; Wang, Liang; Wang, Xiaotong; Li, Manhua; Ding, Haifang; Liu, Qingqing; Chen, Lingling; Zhang, Dongmei; Ni, Runzhou

    2016-08-01

    The suppressor of cytokine signaling SOCS1 is a member of the cytokine signaling pathway inhibitor family, which is induced by the IFN-γ induced JAK signaling pathway. The expression of SOCS1 has been found to increase in Crohn's disease (CD) patients, but the role of SOCS1 in intestinal epithelium is unclear. This study was designed to investigate whether SOCS1 has a role in the death of intestinal epithelial cells and intestinal injury. The results showed that the expression of SOCS1 increased in CD patients, and the expression of SOCS1, p-p53 and PUMA increased in the mouse TNBS induced colitis model. Using IFN-γ treated HT-29 cells as an apoptotic model of intestinal epithelial cells in vitro, we confirmed that SOCS1 promoted apoptosis of intestinal epithelial cells by activating p53. In HT-29 cells which were treated with IFN-γ, the interaction between p53 and SOCS1 and phosphorylation of p53 were significantly higher than untreated cells. When knocking SOCS1 down by using SOCS1 siRNA, phosphorylation of p53 and apoptosis of intestinal epithelial cells which was induced by IFN-γ were significantly inhibited. In summary, our findings suggest that SOCS1 may promote apoptosis of intestinal epithelial cells at least partly through mediating p53 signaling.

  17. Sense of coherence and health. The construction of an amendment to Antonovsky's sense of coherence scale (SOC II).

    Science.gov (United States)

    Flensborg-Madsen, Trine; Ventegodt, Søren; Merrick, Joav

    2006-06-20

    In two previous papers, we concluded that (1) the sense of coherence (SOC) scale developed by Aaron Antonovsky (1923-1994) is unable to prove the association between SOC and the physical health empirically and (2) the SOC scale is unlikely to be a fair materialization of Antonovsky's idea and, thus, unlikely to measure SOC correctly. In order to improve the scale, we developed some new questions that we suggest should be incorporated in a new questionnaire and scale (SOC II) derived directly from Antonovsky's idea and the three key explanatory concepts of SOC: comprehensibility, manageability, and meaningfulness. We hope that this new scale will demonstrate a stronger correlation between SOC and physical health.

  18. Structural basis for c-KIT inhibition by the suppressor of cytokine signaling 6 (SOCS6) ubiquitin ligase

    DEFF Research Database (Denmark)

    Zadjali, Fahad; Pike, Ashley C W; Vesterlund, Mattias

    2011-01-01

    of cytokine signaling 6 (SOCS6) is a member of the SOCS family of E3 ubiquitin ligases that can interact with c-KIT and suppress c-KIT-dependent pathways. Here, we analyzed the molecular mechanisms that determine SOCS6 substrate recognition. Our results show that the SH2 domain of SOCS6 is essential for its...... to substrate residue position pY+6 and envelopes the c-KIT phosphopeptide with a large BG loop insertion that contributes significantly to substrate interaction. We demonstrate that SOCS6 has ubiquitin ligase activity toward c-KIT and regulates c-KIT protein turnover in cells. Our data support a role of SOCS6...... as a feedback inhibitor of SCF-dependent signaling and provides molecular data to account for target specificity within the SOCS family of ubiquitin ligases....

  19. A Bayesian Belief Network framework to predict SOC stock change: the Veneto region (Italy) case study

    Science.gov (United States)

    Dal Ferro, Nicola; Quinn, Claire Helen; Morari, Francesco

    2017-04-01

    A key challenge for soil scientists is predicting agricultural management scenarios that combine crop productions with high standards of environmental quality. In this context, reversing the soil organic carbon (SOC) decline in croplands is required for maintaining soil fertility and contributing to mitigate GHGs emissions. Bayesian belief networks (BBN) are probabilistic models able to accommodate uncertainty and variability in the predictions of the impacts of management and environmental changes. By linking multiple qualitative and quantitative variables in a cause-and-effect relationships, BBNs can be used as a decision support system at different spatial scales to find best management strategies in the agroecosystems. In this work we built a BBN to model SOC dynamics (0-30 cm layer) in the low-lying plain of Veneto region, north-eastern Italy, and define best practices leading to SOC accumulation and GHGs (CO2-equivalent) emissions reduction. Regional pedo-climatic, land use and management information were combined with experimental and modelled data on soil C dynamics as natural and anthropic key drivers affecting SOC stock change. Moreover, utility nodes were introduced to determine optimal decisions for mitigating GHGs emissions from croplands considering also three different IPCC climate scenarios. The network was finally validated with real field data in terms of SOC stock change. Results showed that the BBN was able to model real SOC stock changes, since validation slightly overestimated SOC reduction (+5%) at the expenses of its accumulation. At regional level, probability distributions showed 50% of SOC loss, while only 17% of accumulation. However, the greatest losses (34%) were associated with low reduction rates (100-500 kg C ha-1 y-1), followed by 33% of stabilized conditions (-100 < SOC < 100 kg ha-1 y-1). Land use management (especially tillage operations and soil cover) played a primary role to affect SOC stock change, while climate conditions

  20. Molecular characterization and immune response to lipopolysaccharide (LPS) of the suppressor of cytokine signaling (SOCS)-1, 2 and 3 genes in Nile tilapia (Oreochromis niloticus).

    Science.gov (United States)

    Liu, Cai-Zhi; He, An-Yuan; Chen, Li-Qiao; Limbu, Samwel Mchele; Wang, Ya-Wen; Zhang, Mei-Ling; Du, Zhen-Yu

    2016-03-01

    Suppressor of cytokine signaling (SOCS) proteins are inverse feedback regulators of cytokine and hormone signaling mediated by the Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway that are involved in immunity, growth and development of organisms. In the present study, three SOCS genes, SOCS-1, SOCS-2 and SOCS-3, were identified in an economically important fish, Nile tilapia (Oreochromis niloticus) referred to as NtSOCS-1, NtSOCS-2 and NtSOCS-3. Multiple alignments showed that, the three SOCS molecules share highly conserved functional domains, including the SRC homology 2 (SH2) domain, the extended SH2 subdomain (ESS) and the SOCS box with others vertebrate counterparts. Phylogenetic analysis indicated that NtSOCS-1, 2 and 3 belong to the SOCS type II subfamily. Whereas NtSOCS-1 and 3 showed close evolutionary relationship with Perciformes, NtSOCS-2 was more related to Salmoniformes. Tissue specific expression results showed that, NtSOCS-1, 2 and 3 were constitutively expressed in all nine tissues examined. NtSOCS-1 and 3 were highly expressed in immune-related tissues, such as gills, foregut and head kidney. However, NtSOCS-2 was superlatively expressed in liver, brain and heart. In vivo, NtSOCS-1 and 3 mRNA levels were up-regulated after lipopolysaccharide (LPS) challenge while NtSOCS-2 was down-regulated. In vitro, LPS stimulation increased NtSOCS-3 mRNA expression, however it inhibited the transcription of NtSOCS-1 and 2. Collectively, our findings suggest that, the NtSOCS-1 and 3 might play significant role(s) in innate immune response, while NtSOCS-2 may be more involved in metabolic regulation.

  1. Critical and independent role for SOCS3 in either myeloid or T cells in resistance to Mycobacterium tuberculosis.

    Directory of Open Access Journals (Sweden)

    Berit Carow

    Full Text Available Suppressor of cytokine signalling 3 (SOCS3 negatively regulates STAT3 activation in response to several cytokines such as those in the gp130-containing IL-6 receptor family. Thus, SOCS3 may play a major role in immune responses to pathogens. In the present study, the role of SOCS3 in M. tuberculosis infection was examined. All Socs3(fl/fl LysM cre, Socs3(fl/fl lck cre (with SOCS3-deficient myeloid and lymphoid cells, respectively and gp130(F/F mice, with a mutation in gp130 that impedes binding to SOCS3, showed increased susceptibility to infection with M. tuberculosis. SOCS3 binding to gp130 in myeloid cells conveyed resistance to M. tuberculosis infection via the regulation of IL-6/STAT3 signalling. SOCS3 was redundant for mycobacterial control by macrophages in vitro. Instead, SOCS3 expression in infected macrophages and DCs prevented the IL-6-mediated inhibition of TNF and IL-12 secretion and contributed to a timely CD4+ cell-dependent IFN-γ expression in vivo. In T cells, SOCS3 expression was essential for a gp130-independent control of infection with M. tuberculosis, but was neither required for the control of infection with attenuated M. bovis BCG nor for M. tuberculosis in BCG-vaccinated mice. Socs3(fl/fl lck cre mice showed an increased frequency of γδ+ T cells in different organs and an enhanced secretion of IL-17 by γδ+ T cells in response to infection. Socs3(fl/fl lck cre γδ+ T cells impaired the control of infection with M. tuberculosis. Thus, SOCS3 expression in either lymphoid or myeloid cells is essential for resistance against M. tuberculosis via discrete mechanisms.

  2. Critical and Independent Role for SOCS3 in Either Myeloid or T Cells in Resistance to Mycobacterium tuberculosis

    Science.gov (United States)

    Carow, Berit; Reuschl, Ann-Kathrin; Gavier-Widén, Dolores; Jenkins, Brendan J.; Ernst, Matthias; Yoshimura, Akihiko; Chambers, Benedict J.; Rottenberg, Martin E.

    2013-01-01

    Suppressor of cytokine signalling 3 (SOCS3) negatively regulates STAT3 activation in response to several cytokines such as those in the gp130-containing IL-6 receptor family. Thus, SOCS3 may play a major role in immune responses to pathogens. In the present study, the role of SOCS3 in M. tuberculosis infection was examined. All Socs3fl/fl LysM cre, Socs3fl/fl lck cre (with SOCS3-deficient myeloid and lymphoid cells, respectively) and gp130F/F mice, with a mutation in gp130 that impedes binding to SOCS3, showed increased susceptibility to infection with M. tuberculosis. SOCS3 binding to gp130 in myeloid cells conveyed resistance to M. tuberculosis infection via the regulation of IL-6/STAT3 signalling. SOCS3 was redundant for mycobacterial control by macrophages in vitro. Instead, SOCS3 expression in infected macrophages and DCs prevented the IL-6-mediated inhibition of TNF and IL-12 secretion and contributed to a timely CD4+ cell-dependent IFN-γ expression in vivo. In T cells, SOCS3 expression was essential for a gp130-independent control of infection with M. tuberculosis, but was neither required for the control of infection with attenuated M. bovis BCG nor for M. tuberculosis in BCG-vaccinated mice. Socs3fl/fl lck cre mice showed an increased frequency of γδ+ T cells in different organs and an enhanced secretion of IL-17 by γδ+ T cells in response to infection. Socs3fl/fl lck cre γδ+ T cells impaired the control of infection with M. tuberculosis. Thus, SOCS3 expression in either lymphoid or myeloid cells is essential for resistance against M. tuberculosis via discrete mechanisms. PMID:23853585

  3. Enhancement of leptin receptor signaling by SOCS3 deficiency induces development of gastric tumors in mice.

    Science.gov (United States)

    Inagaki-Ohara, K; Mayuzumi, H; Kato, S; Minokoshi, Y; Otsubo, T; Kawamura, Y I; Dohi, T; Matsuzaki, G; Yoshimura, A

    2014-01-01

    Leptin acts on its receptor (ObR) in the hypothalamus to inhibit food intake and energy expenditure. Leptin and ObR are also expressed in the gastrointestinal tract; however, the physiological significance of leptin signaling in the gut remains uncertain. Suppressor of cytokine signaling 3 (SOCS3) is a key negative feedback regulator of ObR-mediated signaling in the hypothalamus. We now show that gastrointestinal epithelial cell-specific SOCS3 conditional knockout (T3b-SOCS3 cKO) mice developed gastric tumors by enhancing leptin production and the ObRb/signal transducer and activator of transcription 3 (STAT3) signaling pathway. All T3b-SOCS3 cKO mice developed tumors in the stomach but not in the bowels by 2 months of age, even though the SOCS3 deletion occurred in both the epithelium of stomach and bowels. The tumors developed in the absence of the inflammatory response and all cKO mice died within 6 months. These tumors displayed pathology and molecular alterations, such as an increase in MUC2 (Mucin 2, oligomeric mucus/gel-forming) and TFF3 (trefoil factor 3), resembling human intestinal-type gastric tumors. Administration of antileptin antibody to T3b-SOCS3 cKO mice reduced hyperplasia of gastric mucosa, which is the step of the initiation of gastric tumor. These data suggest that SOCS3 is an antigastric tumor gene that suppresses leptin overexpression and ObRb/STAT3 hyperactivation, supporting the hypothesis that the leptin/ObRb/STAT3 axis accelerates tumorigenesis and that it may represent a new therapeutic target for the treatment of gastric cancer.

  4. The impact of soil redistribution on SOC pools in a Mediterranean agroforestry catchment

    Science.gov (United States)

    Quijano, Laura; Gaspar, Leticia; Lizaga, Iván; Navas, Ana

    2017-04-01

    Soil redistribution processes play an important role influencing the spatial distribution patterns of soil and associated soil organic carbon (SOC) at landscape scale. Information on drivers of SOC dynamics is key for evaluating both soil degradation and SOC stability that can affect soil quality and sustainability. 137Cs measurements provide a very effective tool to infer spatial patterns of soil redistribution and quantify soil redistribution rates in different landscapes, but to date these data are scarce in mountain Mediterranean agroecosystems. We evaluate the effect of soil redistribution on SOC and SOC pools in relation to land use in a Mediterranean mountain catchment (246 ha). To this purpose, two hundred and four soil bulk cores were collected on a 100 m grid in the Estaña lakes catchment located in the central sector of the Spanish Pyrenees (31T 4656250N 295152E). The study area is an agroforestry and endorheic catchment characterized by the presence of evaporite dissolution induced dolines, some of which host permanent lakes. The selected landscape is representative of rainfed areas of Mediterranean continental climate with erodible lithology and shallow soils, and characterized by an intense anthropogenic activity through cultivation and water management. The cultivated and uncultivated areas are heterogeneously distributed. SOC and SOC pools (the active and decomposable fraction, ACF and the stable carbon fraction SCF) were measured by the dry combustion method and soil redistribution rates were derived from 137Cs measurements. The results showed that erosion predominated in the catchment, most of soil samples were identified as eroded sites (n=114) with an average erosion rate of 26.9±51.4 Mg ha-1 y-1 whereas the mean deposition rate was 13.0±24.2 Mg ha-1 y-1. In cultivated soils (n=54) the average of soil erosion rate was significantly higher (78.5±74.4 Mg ha-1 y-1) than in uncultivated soils (6.8±10.4 Mg ha-1 y-1). Similarly, the mean of soil

  5. Potential fate of SOC eroded from natural crusted soil surface under simulated wind driven storm

    Science.gov (United States)

    Xiao, Liangang; Fister, Wolfgang; Greenwood, Philip; Hu, Yaxian; Kuhn, Nikolaus J.

    2016-04-01

    Improving the assessment of the impact of soil erosion on carbon (C) cycling requires a better understanding of the redistribution of eroded sediment and associated soil organic carbon (SOC) across agricultural landscapes. Recent studies conducted on dry-sieved aggregates in the laboratory demonstrated that aggregation can profoundly skew SOC redistribution and its subsequent fate by accelerating settling velocities of aggregated sediment compared to mineral grains, which in turn can increase SOC mineralization into greenhouse gases. However, the erodibility of the soil in the field is more variable than in the laboratory due to tillage, crus formation, drying-wetting and freeze-thaw cycles, and biological effects. This study aimed to investigate the potential fate of the SOC eroded from naturally developed soil surface and to compare the observations with those made in the laboratory. Simulated, short, high intensity wind driven storms were conducted on a crusted loam in the field. The sediments were fractionated with a settling tube according to their potential transport distances. The soil mass, SOC concentration and cumulative 80-day CO2 emission of each fraction were identified. The results show: 1) 53% of eroded sediment and 62% of eroded SOC from the natural surface in the field would be deposited across landscapes, which is six times and three times higher compared to that implied by mineral grains, respectively; 2) the preferential deposition of SOC-rich fast-settling sediment potentially releases approximately 50% more CO2 than the same layer of the non-eroded soil; 3) the respiration of the slow-settling fraction that is potentially transported to the aquatic systems was much more active compared to the other fractions and the bulk soil. Our results confirm in general the conclusions drawn from laboratory and thus demonstrate that aggregation can affect the redistribution of sediment associated SOC under field conditions, including an increase in

  6. SOCS3 overexpression inhibits advanced glycation end product-induced EMT in proximal tubule epithelial cells.

    Science.gov (United States)

    Yu, Lin; Zhang, Ying; Zhang, Huimin; Li, Yingtao

    2017-06-01

    Diabetic nephropathy (DN) is among the most severe complications of diabetes mellitus, and may lead to end-stage renal disease. Sustained exposure to advanced glycation end products (AGEs) typically causes renal tubular epithelial cells (TECs) to suffer from an epithelial-to-mesenchymal transition (EMT). However, there remains no consensus regarding the mechanism underlying the cause of EMT in TECs as induced by AGEs. In the present study, we investigated the promotion of EMT in TECs by AGEs, and the activation of Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling. In addition, we constructed a recombinant adenovirus (Ad) that overexpressed suppressor of cytokine signaling 3 (SOCS3), and examined the regulatory role of SOCS3 in the activation of JAK/STAT signaling and the promotion of EMT in TECs. The results demonstrated that AGE-bovine serum albumin (BSA) treatment significantly promoted the expression of EMT-associated proteins, while reducing the expression of the epithelial cell marker, E-cadherin. Furthermore, the Ad-mediated SOCS3 overexpression markedly inhibited the AGE-BSA-induced JAK2/STAT3 activation; phosphorylated JAK2 and phosphorylated STAT3 expression levels were reduced by the Ad-SOCS3 infection, compared with the control Ad (Ad-con) infection, in HK-2 cells subject to AGE-BSA. Moreover, the overexpression of SOCS3 markedly inhibited the AGE-BSA-promoted EMT in HK-2 cells. AGE-BSA-promoted EMT-associated proteins, such as α-smooth muscle actin and collagen I, were reduced by the Ad-SOCS3 virus infection, in contrast to the Ad-con virus infection. Furthermore, reduced E-cadherin expression was reversed by the Ad-SOCS3 virus infection, in contrast to the Ad-con virus infection, in epithelial HK-2 cells. In conclusion, the present study confirmed the inhibitory role of SOCS3 in the AGE-induced EMT in renal TECs, implying the protective role of SOCS3 in DN.

  7. Influence of overexpression of SOCS2 on cells of DN rat.

    Science.gov (United States)

    Bao, Na-Na; Kong, De-Yang; Zhu, Dan; Hao, Li-Rong

    2015-07-01

    To explore the influence and mechanism of overexpression of SOCS2 on diabetic nephropathy (DN) rats and cells. STZ was used to induce male SD rats and SOCS2 was injected into left renal vein. Rats were divided into DN group, DN-Ad-null group and DN-Ad-SOCS2 group. Glucose with high and normal concentration was used to culture HBZY-1 cells and then transfect Ad-SOCS2. HG group, HG-Ad-null group, HG-Ad-SOCS2 group, CG group, CG-Ad-null group, and CG-Ad-SOCS2 group were created. The expression of inflammatory cytokines (MCP-1, TNF-α and IL-6) in kidney tissue of rats, fibrosis related protein (FN, Collagen IV and TGF-β) in kidney tissue and cells of rats, and JAK/STAT signaling pathway related proteins (p-JAK2 and p-STAT3) were tested by western blot. ELISA was used to test the expression of inflammatory cytokines (TNF-α and IL-6) in cells. The expression of inflammatory cytokines in DN rats (MCP-1, TNF-α and IL-6) and cell (TNF-α and IL-6) were increased (P DN animal models and cell models (P DN rats and cells increased while SOCS2 decreased the overexpression of mediated fibrosis related protein in DN model rats and cells (P DN rats and cells increased and the JAK/STAT signaling pathway was activated. Yet, SOCS2 obviously suppressed the expression of the JAK/STAT signaling pathway as well as the related proteins (p-JAK2 and p-STAT3) in both DN rats and cells. The overexpression of SOCS2 can decrease the expression of inflammatory cytokines and fibrosis related proteins in DN rats and cells, and meanwhile suppress the activation of JAK/STAT signaling pathway mediated by DN. Copyright © 2015 Hainan Medical College. Production and hosting by Elsevier B.V. All rights reserved.

  8. Dysregulation of SOCS-Mediated Negative Feedback of Cytokine Signaling in Carcinogenesis and Its Significance in Cancer Treatment

    Science.gov (United States)

    Jiang, Mengmeng; Zhang, Wen-wen; Liu, Pengpeng; Yu, Wenwen; Liu, Ting; Yu, Jinpu

    2017-01-01

    Suppressor of cytokine signaling (SOCS) proteins are major negative feedback regulators of cytokine signaling mediated by the Janus kinase (JAK)-signal transducer and activator of transcription signaling pathway. In particular, SOCS1 and SOCS3 are strong inhibitors of JAKs and can play pivotal roles in the development and progression of cancers. The abnormal expression of SOCS1 and SOCS3 in cancer cells is associated with the dysregulation of cell growth, migration, and death induced by multiple cytokines and hormones in human carcinomas. In addition, the mechanisms involved in SOCS1- and SOCS3-regulated abnormal development and activation of immune cells in carcinogenesis, including T cells, macrophages, dendritic cells, and myeloid-derived suppressor cells, are still unclear. Therefore, this study aims to further discuss the molecules and signal pathways regulating the expression and function of SOCS1 and SOCS3 in various types of cancers and elucidate the feasibility and efficiency of SOCS-based target therapeutic strategy in anticancer treatment. PMID:28228755

  9. Sense of coherence (SOC) among psychotherapists in Austria, differentiated according to number of individually completed training therapy sessions.

    Science.gov (United States)

    Binder, Heinz P; Mesenholl-Strehler, Elke; Pass, Paul; Endler, P Christian

    2006-10-02

    The sense of coherence (according Aaron Antonovsky, 1923-1994, when a person's sense that his/her own life and the world are sufficiently comprehensible, manageable, and meaningful) of Austrian psychotherapists was assessed and compared with a standard sample, as well as with the sense of coherence (SOC) of members of other professions. In addition, the question as to whether psychotherapists who had completed more extensive individual training therapy/self-awareness sessions had a higher SOC than do those with fewer, was addressed. Forty psychotherapists who worked in private practices and various psychosocial health care institutions in Styria, Austria took part in the study. The investigation was conducted in the form of a questionnaire assessment. The evaluation showed that the overall SOC value of the professional group in question was significantly higher than that of the standard sample (162.3 vs. 145.7), as well as other samples (physicians: SOC = 153.8; teachers: SOC = 156.1; physiotherapists SOC = 158.1). Concerning whether psychotherapists who had completed more individual training therapy/self-awareness sessions had higher SOC values than did those with fewer, we found no difference in regard to the overall SOC score or SOC scores for individual components. The SOC of psychotherapists did not seem to depend on the number of additional training therapy/self-awareness sessions.

  10. An Energy-Harvesting Wireless-Interface SoC for Short-Range Data Communication

    Science.gov (United States)

    Mikami, Shinji; Matsuno, Tetsuro; Miyama, Masayuki; Kawaguchi, Hiroshi; Yoshimoto, Masahiko; Ono, Hiroaki

    This paper describes design and verification of a wireless-interface SoC (system-on-a-chip) for a wireless battery-less mouse with short-range data-communication capability. The SoC comprises an RF transmitter and microcontroller. The SoC, which is powered by an electric generator that exploits gyration energy by dragging the mouse, was fabricated using a TSMC 0.18-um CMOS process. The features of the SoC are the adoption of a simple FSK modulation scheme, single-end configuration on the RF transmitter, and specific microcontroller design for mouse operation. We verified that the RF transmitter can make data communication within a 1-m range at 2.17 mW, and the microcontroller consumes 0.03 mW at 1 MHz, which exhibits that the total power consumption is 2.2 mW. This is sufficiently low for the SoC to operate with energy harvesting.

  11. Transport-distance specific SOC distribution: Does it skew erosion induced C fluxes?

    DEFF Research Database (Denmark)

    Hu, Yaxian; Berbe, Asmerat Asefaw; Fogel, Marilyn L.

    2016-01-01

    Abstract The net effect of soil erosion by water, as a sink or source of atmospheric carbon dioxide (CO2), is determined by the spatial (re-)distribution and stability of eroded soil organic carbon (SOC), and the dynamic replacement of eroded C by the production of new photosynthate. The depositi......Abstract The net effect of soil erosion by water, as a sink or source of atmospheric carbon dioxide (CO2), is determined by the spatial (re-)distribution and stability of eroded soil organic carbon (SOC), and the dynamic replacement of eroded C by the production of new photosynthate....... (Land Degrad Dev 11:83–91, 2000) to predict SOC redistribution patterns along hillslopes. The d13C values of soil fractions were more positive at the footslope than on the slope shoulder or at the slope tail, suggesting enhanced decomposition rate of fresh SOC input at the footslope during or after...... emissions during or immediately after transport, must be appropriately accounted for in attempts to quantify the role of soil erosion in terrestrial C sequestration. A SOC erodibility parameter based on actual settling velocity distribution of eroded fractions is needed to better calibrate soil erosion...

  12. Insight into the HIV-1 Vif SOCS-box-ElonginBC interaction.

    Science.gov (United States)

    Lu, Zhisheng; Bergeron, Julien R C; Atkinson, R Andrew; Schaller, Torsten; Veselkov, Dennis A; Oregioni, Alain; Yang, Yi; Matthews, Stephen J; Malim, Michael H; Sanderson, Mark R

    2013-11-13

    The HIV-1 viral infectivity factor (Vif) neutralizes cell-encoded antiviral APOBEC3 proteins by recruiting a cellular ElonginB (EloB)/ElonginC (EloC)/Cullin5-containing ubiquitin ligase complex, resulting in APOBEC3 ubiquitination and proteolysis. The suppressors-of-cytokine-signalling-like domain (SOCS-box) of HIV-1 Vif is essential for E3 ligase engagement, and contains a BC box as well as an unusual proline-rich motif. Here, we report the NMR solution structure of the Vif SOCS-ElonginBC (EloBC) complex. In contrast to SOCS-boxes described in other proteins, the HIV-1 Vif SOCS-box contains only one α-helical domain followed by a β-sheet fold. The SOCS-box of Vif binds primarily to EloC by hydrophobic interactions. The functionally essential proline-rich motif mediates a direct but weak interaction with residues 101-104 of EloB, inducing a conformational change from an unstructured state to a structured state. The structure of the complex and biophysical studies provide detailed insight into the function of Vif's proline-rich motif and reveal novel dynamic information on the Vif-EloBC interaction.

  13. An Online SOC and SOH Estimation Model for Lithium-Ion Batteries

    Directory of Open Access Journals (Sweden)

    Shyh-Chin Huang

    2017-04-01

    Full Text Available The monitoring and prognosis of cell degradation in lithium-ion (Li-ion batteries are essential for assuring the reliability and safety of electric and hybrid vehicles. This paper aims to develop a reliable and accurate model for online, simultaneous state-of-charge (SOC and state-of-health (SOH estimations of Li-ion batteries. Through the analysis of battery cycle-life test data, the instantaneous discharging voltage (V and its unit time voltage drop, V′, are proposed as the model parameters for the SOC equation. The SOH equation is found to have a linear relationship with 1/V′ times the modification factor, which is a function of SOC. Four batteries are tested in the laboratory, and the data are regressed for the model coefficients. The results show that the model built upon the data from one single cell is able to estimate the SOC and SOH of the three other cells within a 5% error bound. The derived model is also proven to be robust. A random sampling test to simulate the online real-time SOC and SOH estimation proves that this model is accurate and can be potentially used in an electric vehicle battery management system (BMS.

  14. Aging and work: how do SOC strategies contribute to job performance across adulthood?

    Science.gov (United States)

    Yeung, Dannii Y; Fung, Helene H

    2009-12-01

    The authors examined the impacts of selection, optimization, and compensation (SOC) strategies-elective selection, loss-based selection, optimization, and compensation-on job performance across adulthood. A cross-sectional survey (Study 1, N=355) and a 5-day experience sampling study (Study 2, N=87) were conducted to assess Chinese insurance sales workers' global and momentary employment of SOC strategies at work and compare the effectiveness of these strategies in predicting their job performance. Study 1 revealed that the use of compensation predicted higher performance maintenance among older workers, whereas the use of elective selection contributed positively to sales productivity for both age groups, with stronger association for younger workers. Study 2 demonstrated that the positive impact of SOC strategies on global and momentary measures of job performance differed across tasks with various difficulty levels. When the task was perceived as highly difficult, older workers' greater use of elective selection predicted higher self-rated task performance; however, the positive association was weaker among younger workers. Older workers' greater use of the 4 SOC strategies was positively associated with sales increases when the task was not difficult or moderately difficult, yet the relationship was negative when the task was highly difficult. A reverse pattern was observed among younger workers. This article contributes to the understanding of working adults' psychological adaptation to the process of aging and reveals the moderating role of task difficulty on the association between SOC strategies and performance outcomes.

  15. RadioAstron space VLBI imaging of polarized radio emission in the high-redshift quasar 0642+449 at 1.6 GHz

    CERN Document Server

    Lobanov, A P; Bruni, G; Kovalev, Y Y; Anderson, J; Bach, U; Kraus, A; Zensus, J A; Lisakov, M M; Sokolovsky, K V; Voytsik, P A

    2015-01-01

    Polarization of radio emission in extragalactic jets at a sub-milliarcsecond angular resolution holds important clues for understanding the structure of the magnetic field in the inner regions of the jets and in close vicinity of the supermassive black holes in the centers of active galaxies. Space VLBI observations provide a unique tool for polarimetric imaging at a sub-milliarcsecond angular resolution and studying the properties of magnetic field in active galactic nuclei on scales of less than 10^4 gravitational radii. A space VLBI observation of high-redshift quasar TXS 0642+449 (OH 471), made at a wavelength of 18 cm (frequency of 1.6 GHz) as part of the Early Science Programme (ESP) of the RadioAstron} mission, is used here to test the polarimetric performance of the orbiting Space Radio Telescope (SRT) employed by the mission, to establish a methodology for making full Stokes polarimetry with space VLBI at 1.6 GHz, and to study the polarized emission in the target object on sub-milliarcsecond scales. ...

  16. PSR B0329+54: substructure in the scatter-broadened image discovered with RadioAstron on baselines up to 330 000 km

    Science.gov (United States)

    Popov, Mikhail V.; Bartel, Norbert; Gwinn, Carl R.; Johnson, Michael D.; Andrianov, Andrey; Fadeev, Evgeny; Joshi, Bhal Chandra; Kardashev, Nikolay; Karuppusamy, Ramesh; Kovalev, Yuri Y.; Kramer, Michael; Rudnitskiy, Alexey; Shishov, Vladimir; Smirnova, Tatiana; Soglasnov, Vladimir A.; Zensus, J. Anton

    2017-02-01

    We have resolved the scatter-broadened image of PSR B0329+54 and detected substructure within it. These results are not influenced by any extended structure of a source but instead are directly attributed to the interstellar medium. We obtained these results at 324 MHz with the ground-space interferometer RadioAstron which included the space radio telescope (SRT), ground-based Westerbork Synthesis Radio Telescope and 64-m Kalyazin Radio Telescope on baseline projections up to 330,000 km in 2013 November 22 and 2014 January 1 to 2. At short 15,000 to 35,000 km ground-space baseline projections the visibility amplitude decreases with baseline length providing a direct measurement of the size of the scattering disk of 4.8$\\pm$0.8 mas. At longer baselines no visibility detections from the scattering disk would be expected. However, significant detections were obtained with visibility amplitudes of 3 to 5% of the maximum scattered around a mean and approximately constant up to 330,000 km. These visibilities reflect substructure from scattering in the interstellar medium and offer a new probe of ionized interstellar material. The size of the diffraction spot near Earth is 17,000$\\pm$3,000 km. With the assumption of turbulent irregularities in the plasma of the interstellar medium, we estimate that the effective scattering screen is located 0.6$\\pm$0.1 of the distance from Earth toward the pulsar.

  17. PSR B0329+54: Substructure in the scatter-broadened image discovered with RadioAstron on baselines up to 330,000 km

    CERN Document Server

    Popov, M V; Gwinn, C R; Johnson, M D; Andrianov, A; Fadeev, E; Joshi, B C; Kardashev, N S; Karuppusamy, R; Kovalev, Y Y; Kramer, M; Rudnitskiy, A; Shishov, V I; Smirnova, T V; Soglasnov, V A; Zensus, J A

    2016-01-01

    We have resolved the scatter-broadened image of PSR B0329+54 and detected substructure within it. These results are not influenced by any extended structure of a source but instead are directly attributed to the interstellar medium. We obtained these results at 324 MHz with the ground-space interferometer RadioAstron which included the space radio telescope (SRT), ground-based Westerbork Synthesis Radio Telescope and 64-m Kalyazin Radio Telescope on baseline projections up to 330,000 km in 2013 November 22 and 2014 January 1 to 2. At short 15,000 to 35,000 km ground-space baseline projections the visibility amplitude decreases with baseline length providing a direct measurement of the size of the scattering disk of 4.8$\\pm$0.8 mas. At longer baselines no visibility detections from the scattering disk would be expected. However, significant detections were obtained with visibility amplitudes of 3 to 5% of the maximum scattered around a mean and approximately constant up to 330,000 km. These visibilities reflec...

  18. Scaling in the space climatology of the auroral indices: is SOC the only possible description?

    Directory of Open Access Journals (Sweden)

    N. W. Watkins

    2002-01-01

    Full Text Available The study of the robust features of the magnetosphere is motivated both by new "whole system" approaches, and by the idea of "space climate" as opposed to "space weather". We enumerate these features for the AE index, and discuss whether self-organised criticality (SOC is the most natural explanation of the "stylised facts" so far known for AE. We identify and discuss some open questions, answers to which will clarify the extent to which AE's properties provide evidence for SOC. We then suggest an SOC-like reconnection-based scenario drawing on the result of Craig (2001 as an explanation of the very recent demonstration by Uritsky et al. (2001b of power laws in several properties of spatiotemporal features seen in auroral images.

  19. AGL24 acts in concert with SOC1 and FUL during Arabidopsis floral transition.

    Science.gov (United States)

    Torti, Stefano; Fornara, Fabio

    2012-10-01

    Arabidopsis plants flower in response to long days (LDs). Exposure of leaves to inductive day lengths activates expression of FLOWERING LOCUS T (FT) protein which moves to the shoot apical meristem (SAM) to induce developmental reprogramming. SUPPRESSOR OF OVEREXPRESSION OF CONSTANS 1 (SOC1) and FRUITFULL (FUL) are induced by FT at the apex. We previously screened the SAM for mRNAs of genes required to promote the floral transition in response to photoperiod, and conducted detailed expression and functional analyses on several putative candidates. Here, we show that expression of AGAMOUS-LIKE 24 (AGL24) is detected at the SAM under SD conditions and increases upon exposure to LDs. Mutations in AGL24 further delay flowering of a soc1 ful double mutant, suggesting that flowering is controlled by AGL24 partly independently of SOC1 and FUL.

  20. Sense of Coherence (SOC) in Christian Orthodox Monks and Nuns in Greece.

    Science.gov (United States)

    Merakou, Kyriakoula; Taki, Stavroula; Barbouni, Anastasia; Antoniadou, Eleni; Theodoridis, Dimitrios; Karageorgos, Georgios; Kourea-Kremastinou, Jeny

    2017-04-01

    This paper aims to investigate the stress management skills of Christian Orthodox monks and nuns, as measured by Antonovsky's scale sense of coherence (SOC). A case-control study was designed to test the hypotheses whether monks and nuns have higher SOC than secular people. The study population consisted of 193 individuals, 96 monks and nuns (study group) and 97 secular men and women (control group). SOC score was higher in monks and nuns as compared to the secular population (p = 0.002), men as compared to women (p = 0.012) and persons of older age (p = 0.004) as compared to younger individuals.

  1. Fundamentals of IP and SoC security design, verification, and debug

    CERN Document Server

    Ray, Sandip; Sur-Kolay, Susmita

    2017-01-01

    This book is about security in embedded systems and it provides an authoritative reference to all aspects of security in system-on-chip (SoC) designs. The authors discuss issues ranging from security requirements in SoC designs, definition of architectures and design choices to enforce and validate security policies, and trade-offs and conflicts involving security, functionality, and debug requirements. Coverage also includes case studies from the “trenches” of current industrial practice in design, implementation, and validation of security-critical embedded systems. Provides an authoritative reference and summary of the current state-of-the-art in security for embedded systems, hardware IPs and SoC designs; Takes a "cross-cutting" view of security that interacts with different design and validation components such as architecture, implementation, verification, and debug, each enforcing unique trade-offs; Includes high-level overview, detailed analysis on implementation, and relevant case studies on desi...

  2. SOCS5 is expressed in primary B and T lymphoid cells but is dispensable for lymphocyte production and function

    DEFF Research Database (Denmark)

    Brender, Christine; Columbus, Ruth; Metcalf, Donald

    2004-01-01

    Suppressors of cytokine signaling (SOCSs) are key regulators of cytokine-induced responses in hematopoietic as well as nonhematopoietic cells. SOCS1 and SOCS3 have been shown to modulate T-cell responses, whereas the roles of other SOCS family members in the regulation of lymphocyte function...... are less clear. Here, we report the generation of mice with a targeted disruption of the Socs5 gene. Socs5(-/-) mice were born in a normal Mendelian ratio and were healthy and fertile. We found that SOCS5 is expressed in primary B and T cells in wild-type mice. However, no abnormalities in the lymphocyte...... to be dispensable for the regulation of lymphocyte function....

  3. Afforestation effects on SOC in former cropland: oak and spruce chronosequences resampled after 13 years.

    Science.gov (United States)

    Bárcena, Teresa G; Gundersen, Per; Vesterdal, Lars

    2014-09-01

    Chronosequences are commonly used to assess soil organic carbon (SOC) sequestration after land-use change, but SOC dynamics predicted by this space-for-time substitution approach have rarely been validated by resampling. We conducted a combined chronosequence/resampling study in a former cropland area (Vestskoven) afforested with oak (Quercus robur) and Norway spruce (Picea abies) over the past 40 years. The aims of this study were (i) to compare present and previous chronosequence trends in forest floor and top mineral soil (0-25 cm) C stocks; (ii) to compare chronosequence estimates with current rates of C stock change based on resampling at the stand level; (iii) to estimate SOC changes in the subsoil (25-50 cm); and (iv) to assess the influence of two tree species on SOC dynamics. The two chronosequence trajectories for forest floor C stocks revealed consistently higher rates of C sequestration in spruce than oak. The chronosequence trajectory was validated by resampling and current rates of forest floor C sequestration decreased with stand age. Chronosequence trends in topsoil SOC in 2011 did not differ significantly from those reported in 1998, however, there was a shift from a negative rate (1998: -0.3 Mg C ha(-1) yr(-1) ) to no change in 2011. In contrast SOC stocks in the subsoil increased with stand age, however, not significantly (P = 0.1), suggesting different C dynamics in and below the former plough layer. Current rates of C change estimated by repeated sampling decreased with stand age in forest floors but increased in the topsoil. The contrasting temporal change in forest floor and mineral soil C sequestration rates indicate a shift in C source-sink strength after approximately 40 years. We conclude that afforestation of former cropland within the temperate region may induce soil C loss during the first decades followed by a recovery phase of yet unknown duration.

  4. Efficient Wrapper/TAM Co-Optimization for SOC Using Rectangle Packing

    CERN Document Server

    Islam, Md Rafiqul; Mahmud, Abdullah Al; Islam, Md Saiful; Babu, Hafiz Md Hasan

    2010-01-01

    The testing time for a system-on-chip(SOC) largely depends on the design of test wrappers and the test access mechanism(TAM).Wrapper/TAM co-optimization is therefore necessary to minimize SOC testing time . In this paper, we propose an efficient algorithm to construct wrappers that reduce testing time for cores. We further propose a new approach for wrapper/TAM co-optimization based on two-dimensional rectangle packing. This approach considers the diagonal length of the rectangles to emphasize on both TAM widths required by a core and its corresponding testing time.

  5. Socs36E Controls Niche Competition by Repressing MAPK Signaling in the Drosophila Testis.

    Directory of Open Access Journals (Sweden)

    Marc Amoyel

    2016-01-01

    Full Text Available The Drosophila testis is a well-established system for studying stem cell self-renewal and competition. In this tissue, the niche supports two stem cell populations, germ line stem cells (GSCs, which give rise to sperm, and somatic stem cells called cyst stem cells (CySCs, which support GSCs and their descendants. It has been established that CySCs compete with each other and with GSCs for niche access, and mutations have been identified that confer increased competitiveness to CySCs, resulting in the mutant stem cell and its descendants outcompeting wild type resident stem cells. Socs36E, which encodes a negative feedback inhibitor of the JAK/STAT pathway, was the first identified regulator of niche competition. The competitive behavior of Socs36E mutant CySCs was attributed to increased JAK/STAT signaling. Here we show that competitive behavior of Socs36E mutant CySCs is due in large part to unbridled Mitogen-Activated Protein Kinase (MAPK signaling. In Socs36E mutant clones, MAPK activity is elevated. Furthermore, we find that clonal upregulation of MAPK in CySCs leads to their outcompetition of wild type CySCs and of GSCs, recapitulating the Socs36E mutant phenotype. Indeed, when MAPK activity is removed from Socs36E mutant clones, they lose their competitiveness but maintain self-renewal, presumably due to increased JAK/STAT signaling in these cells. Consistently, loss of JAK/STAT activity in Socs36E mutant clones severely impairs their self-renewal. Thus, our results enable the genetic separation of two essential processes that occur in stem cells. While some niche signals specify the intrinsic property of self-renewal, which is absolutely required in all stem cells for niche residence, additional signals control the ability of stem cells to compete with their neighbors. Socs36E is node through which these processes are linked, demonstrating that negative feedback inhibition integrates multiple aspects of stem cell behavior.

  6. DMPD: Suppressor of cytokine signaling (SOCS) 2, a protein with multiple functions. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 17070092 Suppressor of cytokine signaling (SOCS) 2, a protein with multiple functio...Epub 2006 Oct 27. (.png) (.svg) (.html) (.csml) Show Suppressor of cytokine signaling (SOCS) 2, a protein with multiple...SOCS) 2, a protein with multiple functions. Authors Rico-Bautista E, Flores-Morales A, Fernandez-Perez L. Pu... functions. PubmedID 17070092 Title Suppressor of cytokine signaling (

  7. Type II SOCS as a feedback repressor for GH-induced Igf1 expression in carp hepatocytes.

    Science.gov (United States)

    Jiang, Xue; Xiao, Jia; He, Mulan; Ma, Ani; Wong, Anderson O L

    2016-05-01

    Type II suppressor of cytokine signaling (SOCS) serve as feedback repressors for cytokines and are known to inhibit growth hormone (GH) actions. However, direct evidence for SOCS modulation of GH-induced insulin-like growth factor 1 (Igf1) expression is lacking, and the post-receptor signaling for SOCS expression at the hepatic level is still unclear. To shed light on the comparative aspects of SOCS in GH functions, grass carp was used as a model to study the role of type II SOCS in GH-induced Igf1 expression. Structural identity of type II SOCS, Socs1-3 and cytokine-inducible SH2-containing protein (Cish), was established in grass carp by 5'/3'-RACE, and their expression at both transcript and protein levels were confirmed in the liver by RT-PCR and LC/MS/MS respectively. In carp hepatocytes, GH treatment induced rapid phosphorylation of JAK2, STATs, MAPK, PI3K, and protein kinase B (Akt) with parallel rises in socs1-3 and cish mRNA levels, and these stimulatory effects on type II SOCS were shown to occur before the gradual loss of igf1 gene expression caused by prolonged exposure of GH. Furthermore, GH-induced type II SOCS gene expression could be negated by inhibiting JAK2, STATs, MEK1/2, P38 (MAPK), PI3K, and/or Akt respectively. In CHO cells transfected with carp GH receptor, over-expression of these newly cloned type II SOCS not only suppressed JAK2/STAT5 signaling with GH treatment but also inhibited GH-induced grass carp Igf1 promoter activity. These results, taken together, suggest that type II SOCS could be induced by GH in the carp liver via JAK2/STATs, MAPK, and PI3K/Akt cascades and serve as feedback repressors for GH signaling and induction of igf1 gene expression.

  8. Expression of suppressor of cytokine signalling 3 (SOCS3) in human bladder epithelial cells infected with uropathogenic Escherichia coli.

    Science.gov (United States)

    Demirel, Isak; Säve, Susanne; Kruse, Robert; Persson, Katarina

    2013-02-01

    Suppressor of cytokine signalling (SOCS) proteins inhibit pro-inflammatory signalling mediated by Janus-activated kinase (JAK)-signal transducer and activator of transcription (STAT) pathways. To evade the immune response some pathogens appear to modify the host SOCS proteins. Uropathogenic Escherichia coli (UPEC) are able to subvert the host response evoked by bladder epithelial cells, but the mechanisms are not fully understood. The objective of this study was to investigate whether UPEC can modify the host SOCS and STAT3 response. Real time RT-PCR studies demonstrated an increased SOCS1 and SOCS3 expression in the isolated human bladder epithelial cell lines (RT-4 and 5637) in response to cytokines. UPEC strain IA2 increased SOCS3, but not SOCS1, mRNA levels with a peak at 6 h after infection. The increase of SOCS3 was confirmed at the protein level by Western blotting. The UPEC strain IA2 caused a time-dependent decrease in the phosphorylation of STAT3. This study demonstrates that UPEC are able to affect SOCS3 and STAT3 signalling in human uroepithelial cells. The finding that UPEC are able to induce mediators involved in suppression of host cytokine signalling may help to elucidate how UPEC may circumvent the host response during urinary tract infection.

  9. ZmSOC1, a MADS-box transcription factor from Zea mays, promotes flowering in Arabidopsis.

    Science.gov (United States)

    Zhao, Suzhou; Luo, Yanzhong; Zhang, Zhanlu; Xu, Miaoyun; Wang, Weibu; Zhao, Yangmin; Zhang, Lan; Fan, Yunliu; Wang, Lei

    2014-11-03

    Zea mays is an economically important crop, but its molecular mechanism of flowering remains largely uncharacterized. The gene, SUPPRESSOR OF OVEREXPRESSION OF CONSTANS 1 (SOC1), integrates multiple flowering signals to regulate floral transition in Arabidopsis. In this study, ZmSOC1 was isolated from Zea mays. Sequence alignment and phylogenetic analysis demonstrated that the ZmSOC1 protein contained a highly conserved MADS domain and a typical SOC1 motif. ZmSOC1 protein was localized in the nucleus in protoplasts and showed no transcriptional activation activity in yeast cells. ZmSOC1 was highly expressed in maize reproductive organs, including filaments, ear and endosperm, but expression was very low in embryos; on the other hand, the abiotic stresses could repress ZmSOC1 expression. Overexpression of ZmSOC1 resulted in early flowering in Arabidopsis through increasing the expression of AtLFY and AtAP1. Overall, these results suggest that ZmSOC1 is a flowering promoter in Arabidopsis.

  10. Qual o Papel da Escola e da Mídia na Obtenção dos Conhecimentos Astronômicos?

    Science.gov (United States)

    da Cunha, W. S.; Voelzke, M. R.; Amaral, L. H.

    2007-08-01

    É amplamente reconhecido que as pessoas em geral têm grande fascínio e interesse pela Astronomia. Por outro lado, o conteúdo dessa área incluído no ensino formal está longe de ser abrangente e suficiente para suprir a demanda. Esse interesse permite aperfeiçoar a divulgação e o ensino não formal de Astronomia através da mídia aliando a adequação do conteúdo à expectativa das pessoas. A reforma do Currículo Básico da Escola Pública da maioria dos Estados brasileiros tem introduzido Astronomia desde a pré-escola até o Ensino Médio. Num estudo realizado com 1180 alunos do Ensino Médio de seis escolas estaduais, revelou-se através da aplicação de um formulário contendo questões que abordavam conhecimentos básicos em Astronomia, como foram adquiridos tais conhecimentos e à infra-estrutura da escola. Para 66,1% dos entrevistados o professor já fez alguma apresentação a respeito de Astronomia. O presente estudo revelou também que 54,4% dos alunos entrevistados adquiriram seus conhecimentos astronômicos na escola, 18,4% através da televisão e 27,1% afirmaram que seus conhecimentos foram obtidos através de outros tipos de mídia (internet, livros didáticos, filmes e revistas). Embora o estudo revele claramente que há certo equilíbrio no meio em que os alunos obtiveram seus conhecimentos astronômicos, a mídia busca não somente sua difusão, mas a disponibilização desse conhecimento de maneira correta, que às vezes, não é atingido, apresentando conceitos sem fundamentação e incorretos. Por outro lado, no dia-a-dia escolar, é comum encontrar professores que vêm para as aulas com concepções prévias, que podem diferir substancialmente das idéias a serem ensinadas, dificultando o aprendizado de futuros conceitos científicos. Uma avaliação criteriosa, avaliando as dificuldades dos professores em determinar o sentido correto dos conceitos e observando a metodologia que utilizam no ensino, poderá proporcionar uma melhor

  11. Increasing SoC Dependability via Known Good Tile NoC Testing

    NARCIS (Netherlands)

    Kerkhoff, Hans G.; Kuiken, O.J.; Zhang, X.

    2008-01-01

    Advanced CMOS technology possibilities, power, communication and flexibility issues as well as the design gap are directing System-on-Chip (SoC) platforms towards Network-on-Chip (NoC) interconnected identical processing tiles (PT) such as the Montium processor [1]. It is broadly acknowledged that

  12. A step toward 'plug and play' robotics with SoC technology

    DEFF Research Database (Denmark)

    Sørensen, Anders Stengaard; Falsig, Simon; Ugilt, Rolf

    p, li { white-space: pre-wrap; } This article describe our progress toward simplifying and streamlining the low level systems integration of experimental robots, combining a System on Chip (SoC) approach with conventional modular approaches. The combined approach has increased flexibility, improv...

  13. A survey of efficient on-chip communications for SoC

    NARCIS (Netherlands)

    Kavaldjiev, N.K.; Smit, G.J.M.

    2003-01-01

    This paper provides a survey of methods and techniques for flexible on-chip inter-processor communications for Systems-on-a-Chip (SoC) components. These devices are applied in battery-powered mobile multimedia devices. A classification is made of the most popular interconnection methods, techniques

  14. E-CMIRC - towards a model for the integration of services between SOCs and CSIRTs

    CSIR Research Space (South Africa)

    Jacobs, P

    2015-07-01

    Full Text Available , including governments. While the focus of a SOC is on the monitoring of technical security controls and critical assets, and the response to attacks and threats, CSIRTs’ main focus is on response and incident management. One postulation is that a CSIRT...

  15. Primary single event effect studies on Xilinx 28-nm System-on-Chip (SoC)

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Yao [Xi’an Jiaotong University, Xi’an, Shaanxi 710049 (China); Liu, Shuhuan, E-mail: shuhuanliu@126.com [Xi’an Jiaotong University, Xi’an, Shaanxi 710049 (China); Du, Xuecheng; Yuan, Yuan; He, Chaohui [Xi’an Jiaotong University, Xi’an, Shaanxi 710049 (China); Ren, Xiaotang [Peking University, Beijing 100000 (China); Du, Xiaozhi; Li, Yonghong [Xi’an Jiaotong University, Xi’an, Shaanxi 710049 (China)

    2016-09-21

    Single Event Effect (SEE) on Xilinx 28-nm System-on-Chip (SoC) was investigated by both simulation and experiments in this study. In the simulation process, typical structure of NAND gate and flip-flop in SoC were designed using Cadence tool. Various kinds of radiation were simulated as pulsed current source in consideration of multilayer wiring and energy loss before reaching the sensitive area. The circuit modules were simulated as SEE occurred and malfunctioned when pulsed current source existed. The changes of the circuit modules output were observed when pulsed current signals were placed at different sensitive nodes or the circuit operated under different conditions. The sensitive nodes in typical modules and the possible reasons of test program malfunction were primarily studied. In the experimental process, SoC chip was irradiated with α particles, protons and laser respectively. The irradiation test results showed that Single Event Upset (SEU) occurred in typical modules of SoC, in accordance with the simulation results.

  16. Baltes' SOC model of successful ageing as a potential framework for stroke rehabilitation.

    Science.gov (United States)

    Donnellan, C; O'Neill, D

    2014-01-01

    The aim of this paper is to explore approaches used to address some stroke rehabilitation interventions and to examine the potential use of one of the life-span theories called the Baltes' model of selective optimisation with compensation (SOC) as a potential framework. Some of the key considerations for a stroke rehabilitation intervention framework are highlighted including accommodating for the life management changes post stroke, alterations in self-regulation, acknowledge losses and focusing on a person-centred approach for transition from acute rehabilitation to the home or community setting. The Baltes' SOC model is then described in terms of these considerations for a stroke rehabilitation intervention framework. The Baltes' SOC model may offer further insights, including ageing considerations, for stroke rehabilitation approaches and interventions. It has potential to facilitate some of the necessary complexities of adjustment required in stroke rehabilitation. However, further development in terms of empirical support is required for using the model as a framework to structure stroke rehabilitation intervention. Implications for Rehabilitation There is a scarcity of theoretical frameworks that can facilitate and be inclusive for all the necessary complexities of adjustment, required in stroke rehabilitation. In addition to motor recovery post stroke, rehabilitation intervention frameworks should be goal orientated; address self-regulatory processes; be person-centred and use a common language for goal planning, setting and attainment. The Baltes' SOC model is one such framework that may address some of the considerations for stroke rehabilitation, including motor recovery and other life management aspects.

  17. On-Line Dependability Enhancement of Multiprocessor SoCs by Resource Management

    NARCIS (Netherlands)

    Braak, ter T.D.; Burgess, S.T.; Hurskainen, H.; Kerkhoff, H.G.; Vermeulen, B.; Zhang, Xiao

    2010-01-01

    This paper describes a new approach towards dependable design of homogeneous multi-processor SoCs in an example satellite-navigation application. First, the NoC dependability is functionally verified via embedded software. Then the Xentium processor tiles are periodically verified via on-line self-t

  18. A Programmable and Configurable Mixed-Mode FPAA SoC

    Science.gov (United States)

    2016-03-17

    A Programmable and Configurable Mixed-Mode FPAA SoC Sahil Shah, Sihwan Kim, Farhan Adil, Jennifer Hasler, Suma George, Michelle Collins, Richard...configurable implementations [7] of Vector -Matrix Multiplication (VMM), demonstrate 1-10 MMAC (/s)/μW power ranges while the digital MAC energy

  19. SOC and now also SIC: store-operated and store-inhibited channels.

    Science.gov (United States)

    Moreno, Claudia; Vaca, Luis

    2011-10-01

    There is a specialized form of calcium influx that involves a close communication between endoplasmic reticulum and the channels at the plasma membrane. In one side store depletion activates channels known as store-operated channels (SOC), which are responsible of the well-studied store-operated calcium entry (SOCE). SOC comprises two different types of channels. Orai, which is exclusively activated by store depletion being the channel responsible of the calcium release-activated calcium current, and transient receptor potential canonical channel, which in contrast, is activated by store depletion only under specific conditions and carries nonselective cationic currents. On the other hand, it has been recently shown that store depletion also inhibits calcium channels. The first member identified, of what we named as store-inhibited channels (SIC), is the L-type voltage-gated calcium channel. Stores control both SOC and SIC by means of the multifunctional protein STIM1. The identification of SOC and SIC opens a new scenario for the role of store depletion in the modulation of different calcium entry pathways, which may satisfy different cellular processes.

  20. Functional SOCS1 polymorphisms are associated with variation in obesity in whites

    DEFF Research Database (Denmark)

    Gylvin, T; Ek, J; Nolsøe, R.;

    2009-01-01

    AIMS/HYPOTHESIS: The suppressor of cytokine signalling 1 (SOCS1) is a natural inhibitor of cytokine and insulin signalling pathways and may also play a role in obesity. In addition, SOCS1 is considered a candidate gene in the pathogenesis of both type 1 diabetes (T1D) and type 2 diabetes (T2D......). The objective was to perform mutation analysis of SOCS1 and to test the identified variations for association to T2D-related quantitative traits, T2D or T1D. METHODS: Mutation scanning was performed by direct sequencing in 27 white Danish subjects. Genotyping was carried out by TaqMan allelic discrimination...... of both the rs33977706 and the rs243330 (-1656G > A) variants to obesity were found (p = 0.047 and p = 0.015) respectively. The rs33977706 affected both binding of a nuclear protein to and the transcriptional activity of the SOCS1 promoter, indicating a relationship between this polymorphism and gene...

  1. An overview of online implementable SOC estimation methods for Lithium-ion batteries

    DEFF Research Database (Denmark)

    Jinhao, Meng; Ricco, Mattia; Guangzhao, Luo

    2017-01-01

    With the popularity of Electrical Vehicles (EVs), Lithium-ion battery industry is also developing rapidly. To ensure the battery safety usage and reduce the average lifecycle cost, accurate State Of Charge (SOC) tracking algorithms for real-time implementation are required in different applications...

  2. SOCS2 mediates the cross talk between androgen and growth hormone signaling in prostate cancer

    DEFF Research Database (Denmark)

    Iglesias Gato, Diego; Chuan, Yin Choy; Wikström, Pernilla

    2014-01-01

    Anabolic signals such as androgens and the growth hormone/insulin-like growth factor 1 (GH/IGF-1) axis play an essential role in the normal development of the prostate but also in its malignant transformation. In this study, we investigated the role of suppressor of cytokine signaling 2 (SOCS2) a...

  3. Mediciones de irradiancia solar y capa de ozono durante el eclipse de Sol de 1994 en el Observatorio Astronómico de Rosario, Argentina

    Science.gov (United States)

    Piacentini, R. D.; Micheletti, M. I.

    We show results of measurements made during the Sun's eclipse of November 3, 1994, in Observatorio Astronómico de Rosario (32o 57' S, 60o 37' W, 25 m a.s.l.). The eclipse begin at 8:41 local hour, reached its maximum with 77% of the surface covered at 9:51 and finished at 11:04. The direct solar irradiance of 300 nm and 313 nm were able to be measured, due to the fact that during the whole period the sky remained completed uncovered (zero percent cloudiness). The measurements were made with the portable ozonometer developed by Tocho and co-workers. They show the characterictic decrease due to the occultation of the source, which is approximately proportional to the surface's diminution. When crossing the earth's atmosphere to arrive to the observation point, these irradiances are affected mainly by the ozone layer, specially the irradiance at lower wavelength, what let it to determine by comparison the thickness of this layer. The total ozone thickness distributed between the troposphere and the stratosphere shows an oscillation, whose amplitude, since the occurence of the maximum of occulation, has a mean value of 4%, and whose period is of approximately 2100 seconds, being both numbers considerably larger than the ones registred by Mims III y Mims (Geophysical Research Letters, 20, 367, 1993) during the eclipse of July 11, 1991 and by Tocho, Da Silva y Rivas (XVIII Quadriennial Ozone Symposiom, Italy, September, 1996) during the same eclipse analyzed in the present work, but observed in Salta. As complementary results, we measured the global irradiance and the ambient temperature during this astronomical event.

  4. RNA interference-mediated silencing of SOCS-1 via lentiviral vector promotes apoptosis of alveolar epithelial cells in vitro.

    Science.gov (United States)

    Qian, Yan-Rong; Zhang, Qiu-Rui; Cheng, Ting; Wan, Huan-Ying; Zhou, Min

    2012-02-01

    Suppressor of cytokine signaling-1 (SOCS1) is a protein that negatively regulates cytokine and growth factor signaling. However, little is known regarding the precise role it plays in idiopathic pulmonary fibrosis. The aim of the present study was to construct a recombinant lentiviral vector for RNA interference targeting the SOCS1 gene and to detect the expression in human alveolar epithelial cells. A lentiviral vector-mediated RNA interference method was used to establish a SOCS1-negative cell line of alveolar origin (A549). Three pairs of complementary small hairpin RNA (shRNA) oligonucleotides targeting the SOCS1 gene were designed, synthesized and inserted into the pPll3.7 vector. Packaged lentivirus particles were obtained after 48 h, and the supernatant was used to transfect the human alveolar epithelial cell line A549. The expression of the SOCS1 protein was detected by Western blotting. MTT assay was used to detect the cell proliferation of alveolar epithelial cells with SOCS1 knockdown. The recombinant plasmids were confirmed by sequencing. The lentivirus-containing supernatant effectively infected the A549 cell line, and the expression of SOCS1 protein was inhibited, which was confirmed by Western blotting in the target cells. MTT assay indicated the inhibition effect for cell proliferation of A549 cells in the SOCS1-RNA interference group, compared to the control group with no interference-mediated silencing of the SOCS1 gene. A lentiviral vector for RNA interference targeting the SOCS1 gene was successfully constructed, and cell survival tests showed that knockdown of the SOCS1 gene promotes the apoptosis of alveolar cells.

  5. Sense of coherence (SOC) related to health and mortality among the very old: the Umeå 85+ study.

    Science.gov (United States)

    Lundman, Berit; Forsberg, Karl Anton; Jonsén, Elisabeth; Gustafson, Yngve; Olofsson, Kent; Strandberg, Gunilla; Lövheim, Hugo

    2010-01-01

    We describe associations between sense of coherence (SOC) and sense of well-being, diseases, physical function and the predictive value of SOC on depression and mortality. The study included 190 participants, aged 85-103 years. Linear correlation analysis was used for relationships between SOC scores and continuous variables. The effects of SOC score on 1- and 4-year mortality, as well as on depression at the 5-year follow-up, were investigated using Cox regression models. The mean SOC score was 71.8±10.2 (±S.D.). SOC score was positively related to well-being (p≤0.001). Heart failure (p=0.009), chronic obstructive pulmonary disease (p=0.015), depression (p=0.015), and osteoarthritis (p=0.032) were significantly associated with low SOC scores, as were high scores on the Geriatric Depression Scale (GDS) (p=0.002). One-year mortality was significantly associated with the SOC score (OR=0.945, confidence interval (CI)=0.898-0.995, p=0.032), while the 4-year mortality was not (OR=0.995, CI=0.973-1.018, p=0.674). The SOC score did not predict depression at 5-year follow-up (OR=0.977, CI=0.937-1.018, p=0.267). Strong SOC was associated with well-being in this group of old people. Low SOC was found among those with diseases known to have a negative influence on daily life.

  6. Dynamics and fate of SOC in tidal marshes along a salinity gradient (Scheldt estuary, Belgium)

    Science.gov (United States)

    Van de Broek, Marijn; Temmermann, Stijn; Merckx, Roel; Wang, Zhengang; Govers, Gerard

    2016-04-01

    Coastal ecosystems have been attributed the potential to store large amounts of organic carbon (OC), often referred to as blue carbon, of which a considerable amount is stored in tidal marsh soils. Large uncertainties still exist with respect to the amount and controlling factors of soil organic carbon (SOC) stored in these ecosystems. Moreover, most research has focused on SOC dynamics of saltmarshes, while brackish and freshwater marshes are often even more productive and thus receive even larger organic carbon inputs. Therefore, in this study the OC dynamics of tidal marsh soils along an estuarine gradient are studied in order to contribute to our knowledge of 1) the stocks, 2) the controlling factors and 3) the fate of SOC in tidal marshes with different environmental characteristics. This research thus contributes to a better understanding of the potential of coastal environments to store organic carbon under future climatic changes. Soil and vegetation samples are collected in tidal salt-, brackish- and freshwater marshes in the Scheldt estuary (Belgium - The Netherlands). At each tidal marsh, three replicate soil cores up to 1.5m depth in 0.03m increments are collected at locations with both a low and a high elevation. These cores are analyzed for OC, stable C and N isotopes, bulk density and texture. Incubation experiments of topsoil samples were conducted and both aboveground and belowground biomass were collected. The results show that SOC stocks (range: 13,5 - 35,4 kg OC m-2), standing biomass (range: 2000 - 7930 g DW m-2) and potential soil respiration of CO2 (range: 0,03 - 0,12 % per unit OC per day) decrease with increasing salinity. This shows that both the amount of OC from local macrophytes and the quality of the organic matter are important factors controlling the SOC stocks. In addition, based on the analysis of stable C and N isotopes, it appears that when a significant fraction of SOC is derived from local macrophytes, higher SOC stocks are

  7. t(8;9(p22;p24/PCM1-JAK2 activates SOCS2 and SOCS3 via STAT5.

    Directory of Open Access Journals (Sweden)

    Stefan Ehrentraut

    Full Text Available Fusions of the tyrosine kinase domain of JAK2 with multiple partners occur in leukemia/lymphoma where they reportedly promote JAK2-oligomerization and autonomous signalling, Affected entities are promising candidates for therapy with JAK2 signalling inhibitors. While JAK2-translocations occur in myeloid, B-cell and T-cell lymphoid neoplasms, our findings suggest their incidence among the last group is low. Here we describe the genomic, transcriptional and signalling characteristics of PCM1-JAK2 formed by t(8;9(p22;p24 in a trio of cell lines established at indolent (MAC-1 and aggressive (MAC-2A/2B phases of a cutaneous T-cell lymphoma (CTCL. To investigate signalling, PCM1-JAK2 was subjected to lentiviral knockdown which inhibited 7 top upregulated genes in t(8;9 cells, notably SOCS2/3. SOCS3, but not SOCS2, was also upregulated in a chronic eosinophilic leukemia bearing PCM1-JAK2, highlighting its role as a central signalling target of JAK2 translocation neoplasia. Conversely, expression of GATA3, a key T-cell developmental gene silenced in aggressive lymphoma cells, was partially restored by PCM1-JAK2 knockdown. Treatment with a selective JAK2 inhibitor (TG101348 to which MAC-1/2A/2B cells were conspicuously sensitive confirmed knockdown results and highlighted JAK2 as the active moiety. PCM1-JAK2 signalling required pSTAT5, supporting a general paradigm of STAT5 activation by JAK2 alterations in lymphoid malignancies. MAC-1/2A/2B--the first JAK2-translocation leukemia/lymphoma cell lines described--display conspicuous JAK/STAT signalling accompanied by T-cell developmental and autoimmune disease gene expression signatures, confirming their fitness as CTCL disease models. Our data support further investigation of SOCS2/3 as signalling effectors, prognostic indicators and potential therapeutic targets in cancers with JAK2 rearrangements.

  8. Suppressor of Cytokine Signaling 6 (SOCS6) Negatively Regulates Flt3 Signal Transduction through Direct Binding to Phosphorylated Tyrosines 591 and 919 of Flt3

    DEFF Research Database (Denmark)

    Kazi, Julhash U; Sun, Jianmin; Phung, Bengt;

    2012-01-01

    The receptor tyrosine kinase Flt3 is an important growth factor receptor in hematopoiesis, and gain-of-function mutations of the receptor contribute to the transformation of acute myeloid leukemia. SOCS6 (suppressor of cytokine signaling 6) is a member of the SOCS family of E3 ubiquitin ligases...... that can regulate receptor tyrosine kinase signal transduction. In this study, we analyzed the role of SOCS6 in Flt3 signal transduction. The results show that ligand stimulation of Flt3 can induce association of SOCS6 and Flt3 and tyrosine phosphorylation of SOCS6. Phosphopeptide fishing indicated...... that SOCS6 binds directly to phosphotyrosines 591 and 919 of Flt3. By using stably transfected Ba/F3 cells with Flt3 and/or SOCS6, we show that the presence of SOCS6 can enhance ubiquitination of Flt3, as well as internalization and degradation of the receptor. The presence of SOCS6 also induces weaker...

  9. Robustness of SOC Estimation Algorithms for EV Lithium-Ion Batteries against Modeling Errors and Measurement Noise

    Directory of Open Access Journals (Sweden)

    Xue Li

    2015-01-01

    Full Text Available State of charge (SOC is one of the most important parameters in battery management system (BMS. There are numerous algorithms for SOC estimation, mostly of model-based observer/filter types such as Kalman filters, closed-loop observers, and robust observers. Modeling errors and measurement noises have critical impact on accuracy of SOC estimation in these algorithms. This paper is a comparative study of robustness of SOC estimation algorithms against modeling errors and measurement noises. By using a typical battery platform for vehicle applications with sensor noise and battery aging characterization, three popular and representative SOC estimation methods (extended Kalman filter, PI-controlled observer, and H∞ observer are compared on such robustness. The simulation and experimental results demonstrate that deterioration of SOC estimation accuracy under modeling errors resulted from aging and larger measurement noise, which is quantitatively characterized. The findings of this paper provide useful information on the following aspects: (1 how SOC estimation accuracy depends on modeling reliability and voltage measurement accuracy; (2 pros and cons of typical SOC estimators in their robustness and reliability; (3 guidelines for requirements on battery system identification and sensor selections.

  10. Assessing Sense of Community on Adolescents: Validating the Brief Scale of Sense of Community in Adolescents (SOC-A)

    Science.gov (United States)

    Chiessi, Monica; Cicognani, Elvira; Sonn, Christopher

    2010-01-01

    Sense of Community (SoC) is a key theoretical construct in community psychology. This study validated a SoC scale for adolescents (SoC-A) in Italy. The scale comprises 20 items and five components: satisfaction of needs and opportunities for involvement; support and emotional connection with peers; support and emotional connection in the…

  11. Psychometric Analyses of the Problem-Focused Style of Coping (PF-SOC) Scale with Taiwanese Samples

    Science.gov (United States)

    Chang, Yuhsuan; Lan, Yu-Ling; Lin, Hung-Yu; Heppner, Puncky Paul

    2012-01-01

    The current research comprises two samples that investigated the psychometric properties of the Problem-Focused Style of Coping (PF-SOC; Heppner, Cook, Wright, & Johnson) scale using two Taiwanese samples. In Sample 1 (N = 809), we investigated the structural dimensions of the PF-SOC using a principal component analysis (PCA) and confirmed…

  12. Hepatitis C virus (HCV)-induced suppressor of cytokine signaling (SOCS) 3 regulates proinflammatory TNF-α responses.

    Science.gov (United States)

    Collins, Aideen S; Ahmed, Suaad; Napoletano, Silvia; Schroeder, Martina; Johnston, James A; Hegarty, John E; O'Farrelly, Cliona; Stevenson, Nigel J

    2014-08-01

    TNF-α is a proinflammatory cytokine, dramatically elevated during pathogenic infection and often responsible for inflammation-induced disease pathology. SOCS proteins are inhibitors of cytokine signaling and regulators of inflammation. In this study, we found that both SOCS1 and SOCS3 were transiently induced by TNF-α and negatively regulate its NF-κB-mediated signal transduction. We discovered that PBMCs from HCV-infected patients have elevated endogenous SOCS3 expression but less TNF-α-mediated IκB degradation and proinflammatory cytokine production than healthy controls. HCV protein expression in Huh7 hepatocytes also induced SOCS3 and directly inhibited TNF-α-mediated IL-8 production. Furthermore, we found that SOCS3 associates with TRAF2 and inhibits TRAF2-mediated NF-κB promoter activity, suggesting a mechanism by which SOCS3 inhibits TNF-α-mediated signaling. These results demonstrate a role for SOCS3 in regulating proinflammatory TNF-α signal transduction and reveal a novel immune-modulatory mechanism by which HCV suppresses inflammatory responses in primary immune cells and hepatocytes, perhaps explaining mild pathology often associated with acute HCV infection.

  13. A Reappraising of Cosmography: the Interface Between Astronomical and Geographic Studies. (Breton Title: Releitura do Conceito de Cosmografia: a Interface Entre os Estudos Astronômicos e Geográficos.) Una Relectura del Concepto de Cosmografía: la Interfase Entre los Estudios Astronómicos y Geográficos

    Science.gov (United States)

    Azevedo Sobreira, Paulo Henrique

    2012-12-01

    The concept of "Cosmography" is in disuse since the 80s of the last century, but the astronomical themes previously discussed in the school subjects of Geography and Cosmography remain in current textbooks. The use of term "Cosmography" was rescued in this research, and the study of its re-signification prompted the appearance of the term Geographic Cosmography. The Geographic Cosmography is a field of studies of the Geography, whose set of knowledge and skills is predominantly scholar. It studies the interface between terrestrial and celestial knowledge, and assigns a geographic significance to them. It examines human and natural relationships with Sidereal Space and its consequences for society and nature. O conceito de "Cosmografia" está em desuso desde os anos 80 do século XX, mas os temas astronômicos anteriormente abordados nas disciplinas escolares de Cosmografia e de Geografia permanecem nos atuais livros didáticos. O uso do termo "Cosmografia" foi resgatado nesta pesquisa e o estudo de sua ressignificação proporcionou o surgimento do termo Cosmografia Geográfica. A Cosmografia Geográfica é um campo de estudos da Geografia, cujo conjunto de conhecimentos e habilidades é predominantemente escolar. Estuda a interface entre os conhecimentos terrestres e os celestes e lhes atribui significância geográfica. Analisa as relações humanas e naturais com o Espaço Sideral e suas consequências para a sociedade e a natureza. Aunque el concepto de "Cosmografía" no se usa desde la década de los '80 del siglo pasado, los temas astronómicos que se enseñaban anteriormente en las asignaturas escolares de Cosmografía y de Geografía permanecen en los actuales libros didácticos. El uso del término "Cosmografía" fue rescatado en esta investigación y el estudio de su resignificación proporcionó el surgimiento del término Cosmografía Geográfica. La Cosmografía Geográfica es un campo de estudio de la Geografía, donde el conjunto de conocimientos y

  14. Changes in Leptin Signaling by SOCS3 Modulate Fasting-Induced Hyperphagia and Weight Regain in Mice.

    Science.gov (United States)

    Pedroso, João A B; Silveira, Marina A; Lima, Leandro B; Furigo, Isadora C; Zampieri, Thais T; Ramos-Lobo, Angela M; Buonfiglio, Daniella C; Teixeira, Pryscila D S; Frazão, Renata; Donato, Jose

    2016-10-01

    Weight regain frequently follows interventions that reduce body weight, leading to a failure in long-term obesity treatment. Inhibitory proteins of the leptin signaling pathway, such as the suppressor of cytokine signaling 3 (SOCS3), have been studied in conditions that predispose animals to obesity. However, whether SOCS3 modulates postrestriction hyperphagia and weight regain remains unknown. Mice lacking SOCS3 protein specifically in leptin receptor (LepR)-expressing cells (LepR SOCS3 knockout [KO]) were generated and studied in fasting and refeeding conditions. LepR SOCS3 KO mice exhibited increased leptin sensitivity in the hypothalamus. Notably, LepR SOCS3 KO males and females showed attenuated food intake and weight regain after 48 hours of fasting. Postrestriction hyperleptinemia was also prevented in LepR SOCS3 KO mice. Next, we studied possible mechanisms and neural circuits involved in the SOCS3 effects. SOCS3 deletion did not prevent fasting- or refeeding-induced c-Fos expression in the arcuate nucleus of the hypothalamus (ARH) nor fasting-induced increased excitability of ARH LepR-expressing cells. On the other hand, SOCS3 ablation reduced the mRNA levels of hypothalamic orexigenic neuropeptides during fasting (neuropeptide Y, agouti-related protein, orexin, and melanin-concentrating hormone). In summary, our findings suggest that increased leptin sensitivity contributes to the maintenance of a reduced body weight after food deprivation. In addition, the attenuated postrestriction food intake observed in mutant mice was not explained by fasting-induced changes in the activity of ARH neurons but exclusively by a lower transcription of orexigenic neuropeptides during fasting. These results indicate a partial dissociation between the regulation of neuronal activity and gene expression in ARH LepR-expressing cells.

  15. Methylation status of the SOCS 1 and JUNB genes in chronic myeloid leukemia patients Padrão de metilação dos genes SOCS 1 e JUNB em pacientes com leucemia mieloide crônica

    Directory of Open Access Journals (Sweden)

    Márcia Cristina R. Pena

    2009-01-01

    Full Text Available Alterations in the methylation status of genes may contribute to the progression of Chronic Myeloid Leukemia (CML. In this study, the methylation status in exon2 of SOCS- 1 and promoter regions of both SOCS- 1 and JUNB were evaluated in CML patients. The methylation status of these genes was analyzed using methylation- specific Polymerase Chain Reaction (MSP in 30 samples from CML patients, 30 samples from these same patients after hematopoietic stem cell transplantation (HSCT and 30 samples from healthy controls. The samples of CML patients presented methylation as follows: JUNB gene (3.3%, promoter region of the SOCS- 1 gene (6.6% and exon2 of the SOCS- 1 gene (46.6%. The samples of the healthy individuals presented methylation (10%, P = 0.002 only in exon 2 of the SOCS- 1 gene. After transplantation, patients presented alterations in the methylation status of the promoter region of the SOCS- 1 gene (6.6%, exon2 of SOCS- 1 (46.6% and the promoter region of the JUNB gene (16.6%. Methylation of the promoter regions of the SOCS- 1 gene and the JUNB gene is not a frequent event in CML. In contrast, SOCS- 1 gene methylation in exon2 is a frequent event, susceptible to alterations in status after HSCT with possible implications for the progression of this disease.Alteração no padrão de metilação gênica pode contribuir para a progressão da leucemia mielóide crônica (LMC. Neste estudo, o padrão de metilação no exon 2 do gene SOCS- 1 e região promotora de ambos SOCS- 1 e JUNB foram avaliadas em pacientes com LMC. O padrão de metilação desses genes foi analisado usando a técnica " methylation- specific polymerase chain reaction (MSP" em 30 amostras de pacientes com LMC, 30 amostras desses mesmos pacientes após transplante de medula óssea (TMO e 30 amostras controle de indivíduos saudáveis. As amostras de pacientes com LMC apresentaram o seguinte padrão de metilação: gene JUNB (3.3%, região promotora do gene SOCS- 1 (6.6% e exon2

  16. Distribution of inhomogeneities in the interstellar plasma in the directions of three distant pulsars from observations with the RadioAstron ground-space interferometer

    Science.gov (United States)

    Popov, M. V.; Andrianov, A. S.; Bartel, N.; Gwinn, C.; Joshi, B. C.; Jauncey, D.; Kardashev, N. S.; Rudnitskii, A. G.; Smirnova, T. V.; Soglasnov, V. A.; Fadeev, E. N.; Shishov, V. I.

    2016-09-01

    The RadioAstron ground-space interferometer has been used to measure the angular sizes of the scattering disks of the three distant pulsars B1641-45, B1749-28, and B1933+16. The observations were carried out with the participation of the Westerbork Synthesis Radio Telescope; two 32-m telescopes at Torun, Poland and Svetloe, Russia (the latter being one antenna of the KVAZAR network); the Saint Croix VLBA antenna; the Arecibo radio telescope; the Parkes, Narrabri (ATCA), Mopra, Hobart, and Ceduna Australian radio telescopes; and the Hartebeesthoek radio telescope in South Africa. The full widths at half maximum of the scattering disks were 27 mas at 1668 MHz for B1641-45, 0.5 mas at 1668 MHz for B1749-28, and 12.3 at 316 MHz and 0.84 mas at 1668 MHz for B1933+16. The characteristic time scales for scatter-broadening of the pulses on inhomogeneities in the interstellar plasma τsc were also measured for these pulsars using various methods. Joint knowledge of the size of the scattering disk and the scatter-broadening time scale enables estimation of the distance to the effective scattering screen d. For B1641-45, d = 3.0 kpc for a distance to the pulsar D = 4.9 kpc, and for B1749-28, d = 0.95 kpc for D = 1.3 kpc. Observations of B1933+16 were carried out simultaneously at 316 and 1668 MHz. The positions of the screen derived using the measurements at the two frequencies agree: d 1 = 2.6 and d 2 = 2.7 kpc, for a distance to the pulsar of 3.7 kpc. Two screens were detected for this pulsar from an analysis of parabolic arcs in the secondary dynamic spectrum at 1668 MHz, at 1.3 and 3.1 kpc. The scattering screens for two of the pulsars are identified with real physical objects located along the lines of sight toward the pulsars: G339.1-04 (B1641-45) and G0.55-0.85 (B1749-28).

  17. Suppressor of cytokine signaling 2 (SOCS2) negatively regulates the expression of antimicrobial peptides by affecting the Stat transcriptional activity in shrimp Marsupenaeus japonicus.

    Science.gov (United States)

    Sun, Jie-Jie; Lan, Jiang-Feng; Xu, Ji-Dong; Niu, Guo-Juan; Wang, Jin-Xing

    2016-09-01

    The suppressor of cytokine signaling (SOCS) family is a kind of negative regulators in the Janus kinase/signal transducer and activator of transcription (Jak/Stat) pathway in mammals and Drosophila. In kuruma shrimp, Marsupenaeus japonicus, SOCS2 is identified and its expression can be stimulated by peptidoglycan and polycytidylic acid. However, if SOCS2 participates in regulating Jak/Stat pathway in shrimp still needs further study. In this study, SOCS2 with Src homology 2 domain and SOCS box was identified in kuruma shrimp, M. japonicus. SOCS2 existed in hemocytes, heart, hepatopancreas, gills, stomach, and intestine, the expression of SOCS2 was upregulated significantly in the hemocytes and intestine of shrimp challenged with Vibrio anguillarum at 6 h. To analyze SOCS2 function in shrimp immunity, bacterial clearance and survival rate were analyzed after knockdown of SOCS2 in shrimp challenged with V. anguillarum. Results showed that bacterial clearance increased, and the survival rate improved significantly comparing with controls. The SOCS2 was expressed in Escherichia coli and the recombinant SOCS2 was injected into shrimp, and Stat phosphorylation and translocation were analyzed. The result showed that "overexpression" of SOCS2 declined Stat phosphorylation level and inhibited Stat translocation into the nucleus. After knockdown of SOCS2 in shrimp prior to V. anguillarum infection, the expression level of antimicrobial peptides, including anti-lipopolysaccharide factors C1, C2 and D1, and Crustin I was upregulated significantly, and the expression of the AMPs was declined after recombinant SOCS2 injection. The SOCS2 expression was also decreased in Stat-knockdown shrimp challenged by V. anguillarum at 6 and 12 h. Therefore, SOCS2 negatively regulates the AMP expression by inhibiting Stat phosphorylation and translocation into nucleus in shrimp, meanwhile, SOCS2 expression was also regulated by Jak/Stat pathway.

  18. The topological quantum phase transitions in Lieb lattice driven by the Rashba SOC and exchange field

    Science.gov (United States)

    Wang, Rui; Qiao, Qian; Wang, Bin; Ding, Xiu-Huan; Zhang, Yi-Fu

    2016-09-01

    The quantum spin Hall (QSH) effect and the quantum anomalous Hall (QAH) effect in Lieb lattice are investigated in the presence of both Rashba spin-orbit coupling (SOC) and uniform exchange field. The Lieb lattice has a simple cubic symmetry, which is characterized by the single Dirac-cone per Brillouin zone and the middle flat band in the band structure. The intrinsic SOC is essentially needed to open the full energy gap in the bulk. The QSH effect could survive even in the presence of the exchange field. In terms of the first Chern number and the spin Chern number, we study the topological nature and the topological phase transition from the time-reversal symmetry broken QSH effect to the QAH effect. For Lieb lattice ribbons, the energy spectrum and the wave-function distributions are obtained numerically, where the helical edge states and the chiral edge states reveal the non-trivial topological QSH and QAH properties, respectively.

  19. System Design of a Trusted SoC and Detailed Analysis of its Secure State Transitions

    Directory of Open Access Journals (Sweden)

    Xianwen Yang

    2010-11-01

    Full Text Available According to the relevant criterion and principle for designing and evaluating various trusted computing chips, we have proposed a new trusted SoC chip, and have given the implementation of its basic functional modules. In detail, we have discussed the design of the trusted SoC security architecture and the main module functional modules such as microprocessor, cryptographic function module, security management module, input/output interface, along with the most important memory management unit. Moreover, we have discussed reliability of relevant parameters and transfer strategy for trusted root in chip development and application, together with the simulation and validation of corresponding functions. At last, we point out that one of the most important further research directions is the trusted measurement of dynamic data and software running in security environment.

  20. FPGA Implementation of Deblocking Filter Custom Instruction Hardware on NIOS - II Based SOC

    Directory of Open Access Journals (Sweden)

    Bolla Leela Naresh

    2011-12-01

    Full Text Available This paper presents a frame work for hardware acceleration for post video processing system implemented on FPGA. The deblocking filter algorithms ported on SOC having Alter a NIOS-II soft core processor.SOC designed with the help of SOPC builder .Custom instructions are chosen by identifying the most frequently used tasks in the algorithm and the instruction set of NIOS-II processor has been extended. Deblocking filter new instruction added to the processor that are implemented in hardware and interfaced to the NIOSII processor. New instruction added to the processor to boost the performance of the deblocking filter algorithm. Use of custom instructions the implemented tasks have been accelerated by 5.88%. The benefit of the speed is obtained at the cost of very small hardware resources.

  1. FPGA Implementation of Deblocking Filter Custom Instruction Hardware on NIOS - II Based SOC

    Directory of Open Access Journals (Sweden)

    Addanki Purna Ramesh

    2012-01-01

    Full Text Available This paper presents a frame work for hardware acceleration for post video processing system implemented on FPGA. The deblocking filter algorithms ported on SOC having Altera NIOS-II soft core processor.SOC designed with the help of SOPC builder .Custom instructions are chosen by identifying the most frequently used tasks in the algorithm and the instruction set of NIOS-II processor has been extended. Deblockingfilter new instruction added to the processor that are implemented in hardware and interfaced to the NIOSII processor. New instruction added to the processor to boost the performance of the deblocking filteralgorithm. Use of custom instructions the implemented tasks have been accelerated by 5.88%. The benefit of the speed is obtained at the cost of very small hardware resources.

  2. Occurrence, fate and removal of synthetic oral contraceptives (SOCs) in the natural environment: a review.

    Science.gov (United States)

    Liu, Ze-hua; Ogejo, Jactone Arogo; Pruden, Amy; Knowlton, Katharine F

    2011-11-15

    Synthetic oral contraceptives (SOCs) are a group of compounds with progestagenic and/or androgenic activities, with some also possessing estrogenic activities. Recent research has documented that some of these emerging contaminants have adverse effects on aquatic organisms at very low concentrations. To facilitate the evaluation of their latent risks, published works on their occurrence and fate in the environment are reviewed. Androgenic/progestagenic relative potencies or relative binding affinity of these SOCs as well as their physicochemical properties and toxicity are summarized. Appropriate analytical methods are outlined for various environmental sample types, including methods of sample preparation and limit of detection/quantification (LOD/LOQ). Finally results on their occurrence and fate in wastewater treatment plants (WWTPs) and other environments are critically examined.

  3. Early postnatal hyperalimentation impairs renal function via SOCS-3 mediated renal postreceptor leptin resistance.

    Science.gov (United States)

    Alcazar, Miguel Angel Alejandre; Boehler, Eva; Rother, Eva; Amann, Kerstin; Vohlen, Christina; von Hörsten, Stephan; Plank, Christian; Dötsch, Jörg

    2012-03-01

    Early postnatal hyperalimentation has long-term implications for obesity and developing renal disease. Suppressor of cytokine signaling (SOCS) 3 inhibits phosphorylation of signal transducer and activator of transcription (STAT) 3 and ERK1/2 and thereby plays a pivotal role in mediating leptin resistance. In addition, SOCS-3 is induced by both leptin and inflammatory cytokines. However, little is known about the intrinsic-renal leptin synthesis and function. Therefore, this study aimed to elucidate the implications of early postnatal hyperalimentation on renal function and on the intrinsic-renal leptin signaling. Early postnatal hyperalimentation in Wistar rats during lactation was induced by litter size reduction at birth (LSR) either to LSR10 or LSR6, compared with home cage control male rats. Assessment of renal function at postnatal day 70 revealed decreased glomerular filtration rate and proteinuria after LSR6. In line with this impairment of renal function, renal inflammation and expression as well as deposition of extracellular matrix molecules, such as collagen I, were increased. Furthermore, renal expression of leptin and IL-6 was up-regulated subsequent to LSR6. Interestingly, the phosphorylation of Stat3 and ERK1/2 in the kidney, however, was decreased after LSR6, indicating postreceptor leptin resistance. In accordance, neuropeptide Y (NPY) gene expression was down-regulated; moreover, SOCS-3 protein expression, a mediator of postreceptor leptin resistance, was strongly elevated and colocalized with NPY. Thus, our findings not only demonstrate impaired renal function and profibrotic processes but also provide compelling evidence of a SOCS-3-mediated intrinsic renal leptin resistance and concomitant up-regulated NPY expression as an underlying mechanism.

  4. Utilizing Predictors for Efficient Thermal Management in Multiprocessor SoCs

    Science.gov (United States)

    2009-10-01

    IEEE Authorized licensed use limited to: Univ of Calif San Diego. Downloaded on October 12, 2009 at 08:29 from IEEE Xplore . Restrictions apply...from IEEE Xplore . Restrictions apply. COŞKUN et al.: UTILIZING PREDICTORS FOR EFFICIENT THERMAL MANAGEMENT IN MULTIPROCESSOR SoCs 1505 values in...dependent on the power Authorized licensed use limited to: Univ of Calif San Diego. Downloaded on October 12, 2009 at 08:29 from IEEE Xplore . Restrictions

  5. Analysis of CSIRT/SOC Incidents and Continuous Monitoring of Threats

    Science.gov (United States)

    Wang, John; Ishisoko, Katsutoshi C.

    2012-01-01

    Security Operations Centers (SOC) contain a wealth of data which, if properly classified and tagged upfront, can yield a wealth of real-time information about your organizations IT Security posture, risks, and threats. These include answers to relevant and actionable questions such as: What are our biggest threats? Who is attacking us and what do they want? What controls are working or not working? How effective was the new technology we just implemented? What is our ROI?

  6. Tipología de recursos astronómicos históricos y fondos documentales en las cartotecas españolas: estado de la cuestión

    Directory of Open Access Journals (Sweden)

    Alonso-Lifante, M. Pilar

    2015-09-01

    Full Text Available The state of the art about a type of specialised resource with great historical and scientific value is presented: the astronomical documentation. First of all, the main types of astronomical resources are defined focusing on their historical evolution. Secondly, the result of a survey carried out between April and May 2014 about the astronomical collections in Spanish map libraries and archives is shown taking as a reference the IBERCARTO directory of 2012. Conclusions show that almost half of queried libraries and archives map have these type of documents, but disseminated in different collections. Moreover, around 70% of the institutions have catalogued all of their astronomical documentation and have used the classical encoding (MARC 21 and cataloguing standards (ISBD and ISAD(G, although recent studies have shown that these standards are not the most suitable ones to describe it. Hence, a satisfactory scientific information retrieval is not achieved.Se presenta el estado de la cuestión de un tipo de recurso especializado de gran valor histórico y científico: la documentación astronómica. Para ello, en primer lugar se definen los principales tipos de recursos astronómicos existentes señalando su evolución histórica. En segundo lugar se presentan los resultados de un estudio, realizado entre abril y mayo de 2014, sobre los fondos astronómicos existentes en cartotecas españolas, tomando como referencia el directorio de IBERCARTO de 2012. Las conclusiones indican que casi la mitad de las cartotecas encuestadas conservan documentos de este tipo, encontrándose dispersos en diferentes colecciones. Además, en torno al 70% de las instituciones tienen catalogada toda su documentación astronómica, descrita con los estándares clásicos de codificación (MARC 21 y catalogación (ISBD e ISAD(G, aunque recientes estudios han puesto de manifiesto que estos estándares no son los más adecuados para describirla, por lo que actualmente no se

  7. Eppur si muove: una secuencia contextualizada de indagación y comunicación científica sobre el sistema astronómico Sol-Tierra

    OpenAIRE

    Jordi Domènech Casal

    2015-01-01

    Se describe el desarrollo de una actividad de indagación sobre el sistema astronómico Sol-Tierra articulada alrededor de varios referentes contextuales (objetos, términos de vocabulario, espacios) que el alumno debe manipular e interpretar. Como parte de la actividad, se usan andamios didácticos de distintos tipos (lingüísticos, de análisis, estructuradores) para enseñar al alumnado a investigar y comunicar científicamente. La experiencia promueve la contextualización de los modelo c...

  8. Dynamic power management for UML modeled applications on multiprocessor SoC

    Science.gov (United States)

    Kukkala, Petri; Arpinen, Tero; Setälä, Mikko; Hännikäinen, Marko; Hämäläinen, Timo D.

    2007-02-01

    The paper presents a novel scheme of dynamic power management for UML modeled applications that are executed on a multiprocessor System-on-Chip (SoC) in a distributed manner. The UML models for both application and architecture are designed according to a well-defined UML profile for embedded system design, called TUT-Profile. Application processes are considered as elementary units of distributed execution, and their mapping on a multiprocessor SoC can be dynamically changed at run-time. Our approach on the dynamic power management balances utilized processor resources against current workload at runtime by (1) observing the processor and workload statistics, (2) re-evaluating the amount of required resources (i.e. the number of active processors), and (3) re-mapping the application processes to the minimum set of active processors. The inactive processors are set to a power-save state by using clock-gating. The approach integrates the well-known power management techniques tightly with the UML based design of embedded systems in a novel way. We evaluated the dynamic power management with a WLAN terminal implemented on a multiprocessor SoC on Altera Stratix II FPGA containing up to five Nios II processors and dedicated hardware accelerators. Measurements proved up to 21% savings in the power consumption of the whole FPGA board.

  9. An Infrastructural IP for Interactive MPEG-4 SoC Functional Verification

    Directory of Open Access Journals (Sweden)

    Trio Adiono

    2013-09-01

    Full Text Available This paper introduces a specific architecture including an infrastructural IP for functional verification and diagnostics, which is suitable for functional core-based testing of an MPEG4 SoC. Our advanced MPEG4 SoC results in a high complexity SoC with limited physical access to many different functional cores. The proposed test method provides direct monitoring and control for each core, which enables core verification at actual speed. It significantly decreases the verification time due to the large number of required test vectors in typical MPEG4 verification. Furthermore, it also makes the system scalable for functional core expansion due to upgrading of standards. The proposed infrastructural IP is also linked to PC-based interactive tools to simplify the verification of individual and integrated cores. It also provides detailed diagnostic data that enables simple system debugging. The debugging tools also feature test-pattern generation and simulation of expected values. Actual system implementation has shown full functionality of our proposed method.

  10. An Infrastructural IP for Interactive MPEG-4 SoC Functional Verification

    Directory of Open Access Journals (Sweden)

    Trio Adiono

    2009-05-01

    Full Text Available This paper introduces a specific architecture including an infrastructural IP for functional verification and diagnostics, which is suitable for functional core-based testing of an MPEG4 SoC. Our advanced MPEG4 SoC results in a high complexity SoC with limited physical access to many different functional cores. The proposed test method provides direct monitoring and control for each core, which enables core verification at actual speed. It significantly decreases the verification time due to the large number of required test vectors in typical MPEG4 verification. Furthermore, it also makes the system scalable for functional core expansion due to upgrading of standards. The proposed infrastructural IP is also linked to PC-based interactive tools to simplify the verification of individual and integrated cores. It also provides detailed diagnostic data that enables simple system debugging. The debugging tools also feature test-pattern generation and simulation of expected values. Actual system implementation has shown full functionality of our proposed method.

  11. Gypenoside Attenuates β Amyloid-Induced Inflammation in N9 Microglial Cells via SOCS1 Signaling

    Directory of Open Access Journals (Sweden)

    Hui Cai

    2016-01-01

    Full Text Available Reducing β amyloid- (Aβ- induced microglial activation is believed to be effective in treating Alzheimer’s disease (AD. Microglia can be activated into classic activated state (M1 state or alternative activated state (M2 state, and the former is harmful; in contrast, the latter is beneficial. Gypenoside (GP is the major bioactive constituent of Gynostemma pentaphyllum, a traditional Chinese herb medicine. In this study, we hypothesized that GP attenuates Aβ-induced microglial activation by ameliorating microglial M1/M2 states, and the process may be mediated by suppressor of cell signaling protein 1 (SOCS1. In this study, we found that Aβ exposure increased the levels of microglial M1 markers, including iNOS expression, tumor necrosis factor α (TNF-α, interleukin 1β (IL-1β, and IL-6 releases, and coadministration of GP reversed the increase of M1 markers and enhanced the levels of M2 markers, including arginase-1 (Arg-1 expression, IL-10, brain-derived neurotrophic factor (BDNF, and glial cell-derived neurotrophic factor (GDNF releases in the Aβ-treated microglial cells. SOCS1-siRNA, however, significantly abolished the GP-induced effects on the levels of microglial M1 and M2 markers. These findings indicated that GP attenuates Aβ-induced microglial activation by ameliorating M1/M2 states, and the process may be mediated by SOCS1.

  12. Gypenoside Attenuates β Amyloid-Induced Inflammation in N9 Microglial Cells via SOCS1 Signaling

    Science.gov (United States)

    Cai, Hui; Liang, Qianlei; Ge, Guanqun

    2016-01-01

    Reducing β amyloid- (Aβ-) induced microglial activation is believed to be effective in treating Alzheimer's disease (AD). Microglia can be activated into classic activated state (M1 state) or alternative activated state (M2 state), and the former is harmful; in contrast, the latter is beneficial. Gypenoside (GP) is the major bioactive constituent of Gynostemma pentaphyllum, a traditional Chinese herb medicine. In this study, we hypothesized that GP attenuates Aβ-induced microglial activation by ameliorating microglial M1/M2 states, and the process may be mediated by suppressor of cell signaling protein 1 (SOCS1). In this study, we found that Aβ exposure increased the levels of microglial M1 markers, including iNOS expression, tumor necrosis factor α (TNF-α), interleukin 1β (IL-1β), and IL-6 releases, and coadministration of GP reversed the increase of M1 markers and enhanced the levels of M2 markers, including arginase-1 (Arg-1) expression, IL-10, brain-derived neurotrophic factor (BDNF), and glial cell-derived neurotrophic factor (GDNF) releases in the Aβ-treated microglial cells. SOCS1-siRNA, however, significantly abolished the GP-induced effects on the levels of microglial M1 and M2 markers. These findings indicated that GP attenuates Aβ-induced microglial activation by ameliorating M1/M2 states, and the process may be mediated by SOCS1. PMID:27213058

  13. A Cryptographic SoC for Robust Protection of Secret Keys in IPTV DRM Systems

    Science.gov (United States)

    Lee, Sanghan; Yang, Hae-Yong; Yeom, Yongjin; Park, Jongsik

    The security level of an internet protocol television (IPTV) digital right management (DRM) system ultimately relies on protection of secret keys. Well known devices for the key protection include smartcards and battery backup SRAMs (BB-SRAMs); however, these devices could be vulnerable to various physical attacks. In this paper, we propose a secure and cost-effective design of a cryptographic system on chip (SoC) that integrates the BB-SRAM with a cell-based design technique. The proposed SoC provides robust safeguard against the physical attacks, and satisfies high-speed and low-price requirements of IPTV set-top boxes. Our implementation results show that the maximum encryption rate of the SoC is 633Mb/s. In order to verify the data retention capabilities, we made a prototype chip using 0.18µm standard cell technology. The experimental results show that the integrated BB-SRAM can reliably retain data with a 1.4µA leakage current.

  14. Regulation of pancreatic beta-cell mass and proliferation by SOCS-3

    DEFF Research Database (Denmark)

    Lindberg, K; Rønn, S G; Tornehave, D

    2005-01-01

    Growth hormone and prolactin are important growth factors for pancreatic beta-cells. The effects exerted by these hormones on proliferation and on insulin synthesis and secretion in beta-cells are largely mediated through the Janus kinase (JAK)/signal transducer and activator of transcription (ST......-type littermates following an oral glucose-tolerance test. Together these data suggest that SOCS-3 modulates cytokine signaling in pancreatic beta-cells and therefore potentially could be a candidate target for development of new treatment strategies for diabetes.......Growth hormone and prolactin are important growth factors for pancreatic beta-cells. The effects exerted by these hormones on proliferation and on insulin synthesis and secretion in beta-cells are largely mediated through the Janus kinase (JAK)/signal transducer and activator of transcription (STAT......) signaling pathway. Suppressors of cytokine signaling (SOCS) proteins are specific inhibitors of the JAK/STAT pathway acting through a negative-feedback loop. To investigate in vivo effects of SOCS-3 in growth hormone (GH)/prolactin signaling in beta-cells we generated transgenic mice with beta...

  15. Development of a Danish national vis—NIR soil spectral library for SOC determination

    DEFF Research Database (Denmark)

    Knadel, Maria; Deng, Fan; Greve, Mogens Humlekrog;

    The development of a soil spectral library is a prerequisite for using vis-NIR spectroscopy for soil analysis. The aim of this study is twofold: (i) to create a Danish national soil library with a main focus on building a model for SOC determination and (ii) to test the feasibility of using...... the library to predict SOC from new dry and moist samples, before and after spiking the library with additional local samples. Soils spectra were obtained using Labspec 5100 (350-2500 nm) vis-NIR sensor. The best validation model resulted in RMSEP value of 0.31, R2 value of 0.79 and RPD value of 2.......3. The prediction on independent data resulted in very similar results: RMSEP=0.29, R2 of 0.81 and RPD of 2.4. Before spiking the library moderate SOC predictions were obtained for the new dry soils. Prediction on moist samples however, required prior spiking the global library with moist samples from the new...

  16. Parametric dense stereovision implementation on a system-on chip (SoC).

    Science.gov (United States)

    Gardel, Alfredo; Montejo, Pablo; García, Jorge; Bravo, Ignacio; Lázaro, José L

    2012-01-01

    This paper proposes a novel hardware implementation of a dense recovery of stereovision 3D measurements. Traditionally 3D stereo systems have imposed the maximum number of stereo correspondences, introducing a large restriction on artificial vision algorithms. The proposed system-on-chip (SoC) provides great performance and efficiency, with a scalable architecture available for many different situations, addressing real time processing of stereo image flow. Using double buffering techniques properly combined with pipelined processing, the use of reconfigurable hardware achieves a parametrisable SoC which gives the designer the opportunity to decide its right dimension and features. The proposed architecture does not need any external memory because the processing is done as image flow arrives. Our SoC provides 3D data directly without the storage of whole stereo images. Our goal is to obtain high processing speed while maintaining the accuracy of 3D data using minimum resources. Configurable parameters may be controlled by later/parallel stages of the vision algorithm executed on an embedded processor. Considering hardware FPGA clock of 100 MHz, image flows up to 50 frames per second (fps) of dense stereo maps of more than 30,000 depth points could be obtained considering 2 Mpix images, with a minimum initial latency. The implementation of computer vision algorithms on reconfigurable hardware, explicitly low level processing, opens up the prospect of its use in autonomous systems, and they can act as a coprocessor to reconstruct 3D images with high density information in real time.

  17. A configurable and low-power mixed signal SoC for portable ECG monitoring applications.

    Science.gov (United States)

    Kim, Hyejung; Kim, Sunyoung; Van Helleputte, Nick; Artes, Antonio; Konijnenburg, Mario; Huisken, Jos; Van Hoof, Chris; Yazicioglu, Refet Firat

    2014-04-01

    This paper describes a mixed-signal ECG System-on-Chip (SoC) that is capable of implementing configurable functionality with low-power consumption for portable ECG monitoring applications. A low-voltage and high performance analog front-end extracts 3-channel ECG signals and single channel electrode-tissue-impedance (ETI) measurement with high signal quality. This can be used to evaluate the quality of the ECG measurement and to filter motion artifacts. A custom digital signal processor consisting of 4-way SIMD processor provides the configurability and advanced functionality like motion artifact removal and R peak detection. A built-in 12-bit analog-to-digital converter (ADC) is capable of adaptive sampling achieving a compression ratio of up to 7, and loop buffer integration reduces the power consumption for on-chip memory access. The SoC is implemented in 0.18 μm CMOS process and consumes 32 μ W from a 1.2 V while heart beat detection application is running, and integrated in a wireless ECG monitoring system with Bluetooth protocol. Thanks to the ECG SoC, the overall system power consumption can be reduced significantly.

  18. Sense of coherence (SOC) may reduce the effects of occupational stress on mental health status among Japanese factory workers.

    Science.gov (United States)

    Urakawa, Kayoko; Yokoyama, Kazuhito

    2009-10-01

    To examine if sense of coherence (SOC) can reduce the adverse effects of job stress on mental health status, self-administered questionnaires were distributed among 740 workers in a manufacturing industry. The questionnaire contained SOC, Job Content Questionnaire (JCQ), and General Health Questionnaire (GHQ-12). Complete answers were recovered from 466 workers (62.8%), consisting of 387 males and 79 females, with ages of 45.1 + or - 12.0 yr, and used for the analysis. The logistic regression analysis revealed the followings: Both for males and females, high GHQ was significantly associated with scores on SOC and JCQ job demand subscale, i.e. the mental health status was adversely related to job demand whereas it was positively associated with SOC. Similarly, the mental health status was affected adversely by managerial work in males, whereas was positively by co-workers support in females. Thus, high SOC enables workers to cope with their job demand, which is a potent job stressor, indicating that SOC is an important factor determining their coping ability to job stress for both genders. Male managerial employees may cope with their strong job stress because of high SOC, protecting their mental health status. Social support seems also significant for prevention of mental well-being of female workers from work-related stressors.

  19. [Impact of land use change and cultivation measures on soil organic carbon (SOC) and its 13C values].

    Science.gov (United States)

    Meng, Fan-qiao; Kuang, Xing; Du, Zhang-liu; Wu, Wen-liang; Guo, Yan-bin

    2010-08-01

    In Quzhou County, Hebei Province where now intensive farming system is operated, original grassland and farming land under different tillage, crop straw return and fertilization measures were studied using isotope carbon for the analysis of the impact on soil organic carbon (SOC) properties. The research indicated that after change into farmland (34 years), SOC is significantly reduced and for 1 m of soil layer, the scope of reduction is from 13.3%-35% and this decrease happens in 0-40 cm of soil layer. After 8 years of fertilization, SOC can be increased at 0.83 g x kg(-1). No-tillage can significantly increase the SOC especially in 0-10 cm but plough will increase the SOC at 10-15 cm and 15-20 cm. Change of delta13 C of SOC due to land use change mainly happens in 0-20 cm, where input of organic materials from maize stored. In soil layer of 0-5 cm, only maximum 18% of SOC is from crop residues and in 15-20 cm, this percentage is about 5%.

  20. Influencia de la marea astronómica sobre las variaciones del nivel del Río Negro en la zona de Carmen de Patagones

    Directory of Open Access Journals (Sweden)

    Enrique D'Onofrio

    2010-12-01

    Full Text Available El Río Negro, límite natural entre las provincias de Buenos Aires y Río Negro, es uno de los ríos más importantes de la Patagonia que desemboca en el Océano Atlántico. Es navegable desde su desembocadura hasta Carmen de Patagones por embarcaciones de hasta 2,04 m de calado, dificultándose por irregularidades en la profundidad aguas arriba. La onda de marea proveniente del océano Atlántico ingresa al río haciendo que este adopte un régimen semidiurno hasta Carmen de Patagones. El conocimiento de la onda de marea en este tramo del río es de fundamental importancia para la calibración de modelos numéricos, el perfeccionamiento de los sistemas de alerta de inundaciones y la toma de decisiones relacionadas con el manejo costero. En este trabajo se analizan cuatro series de mediciones de marea, dos obtenidas en el hidrómetro de Carmen de Patagones con una duración de 608 y 731 días, una de 77 días proveniente de un mareómetro instalado en el kilómetro 18 del río y una de 79 días obtenida con un sensor de presión fondeado en proximidades de Punta Redonda (desembocadura del Río Negro. Se calculan y comparan los espectros de potencia de las alturas observadas en los tres sitios para detectar los cambios energéticos producidos en la banda de frecuencias correspondientes a la marea astronómica. De su comparación surge que la energía de las componentes semidiurnas y diurnas disminuye un 22% y un 45% respectivamente desde la desembocadura del Río Negro hasta Carmen de Patagones. En contraposición se observa un ligero aumento de la energía correspondiente a las frecuencias de las componentes cuarto diurnas. Esto se debe fundamentalmente a procesos no lineales inducidos por aguas someras y a irregularidades en la morfología del fondo del río. Para obtener las amplitudes y épocas de la marea se realizan análisis armónicos por el método de cuadrados mínimos. Las amplitudes de las componentes diurnas en Carmen de Patagones

  1. Increased linear bone growth by GH in the absence of SOCS2 is independent of IGF-1.

    Science.gov (United States)

    Dobie, Ross; Ahmed, Syed F; Staines, Katherine A; Pass, Chloe; Jasim, Seema; MacRae, Vicky E; Farquharson, Colin

    2015-11-01

    Growth hormone (GH) signaling is essential for postnatal linear bone growth, but the relative importance of GHs actions on the liver and/or growth plate cartilage remains unclear. The importance of liver derived insulin like-growth factor-1 (IGF-1) for endochondral growth has recently been challenged. Here, we investigate linear growth in Suppressor of Cytokine Signaling-2 (SOCS2) knockout mice, which have enhanced growth despite normal systemic GH/IGF-1 levels. Wild-type embryonic ex vivo metatarsals failed to exhibit increased linear growth in response to GH, but displayed increased Socs2 transcript levels (P GH treatment enhanced metatarsal linear growth over a 12 day period. Despite this increase, IGF-1 transcript and protein levels were not increased in response to GH. In accordance with these data, IGF-1 levels were unchanged in GH-challenged postnatal Socs2(-/-) conditioned medium despite metatarsals showing enhanced linear growth. Growth-plate Igf1 mRNA levels were not elevated in juvenile Socs2(-/-) mice. GH did however elevate IGF-binding protein 3 levels in conditioned medium from GH challenged metatarsals and this was more apparent in Socs2(-/-) metatarsals. GH did not enhance the growth of Socs2(-/-) metatarsals when the IGF receptor was inhibited, suggesting that IGF receptor mediated mechanisms are required. IGF-2 may be responsible as IGF-2 promoted metatarsal growth and Igf2 expression was elevated in Socs2(-/-) (but not WT) metatarsals in response to GH. These studies emphasise the critical importance of SOCS2 in regulating GHs ability to promote bone growth. Also, GH appears to act directly on the metatarsals of Socs2(-/-) mice, promoting growth via a mechanism that is independent of IGF-1.

  2. Are soils of Iowa USA currently a carbon sink or source? Simulated changes in SOC stock from 1972 to 2007

    Science.gov (United States)

    Liu, S.; Tan, Z.; Li, Z.; Zhao, S.; Yuan, W.

    2011-01-01

    Upscaling the spatial and temporal changes in carbon (C) stocks and fluxes from sites to regions is a critical and challenging step toward improving our understanding of the dynamics of C sources and sinks over large areas. This study simulated soil organic C (SOC) dynamics within 0-100cm depth of soils across the state of Iowa in the USA from 1972 to 2007 using the General Ensemble biogeochemical Modeling System (GEMS). The model outputs with variation coefficient were analyzed and assembled from simulation unit to the state scale based upon major land use types at annual step. Results from this study indicate that soils (within a depth of 0-100cm) in Iowa had been a SOC source at a rate of 190??380kg Cha-1yr-1. This was likely caused by the installation of a massive drainage system which led to the release of SOC from deep soil layers previously protected under poor drainage conditions. The annual crop rotation was another major force driving SOC variation and resulted in spatial variability of annual budgets in all croplands. Annual rate of change of SOC stocks in all land types depended significantly on the baseline SOC levels; soils with higher SOC levels tended to be C sources, and those with lower levels tended to be C sinks. Management practices (e.g., conservation tillage and residue management practices) slowed down the C emissions from Iowa soils, but could not reverse the general trend of net SOC loss in view of the entire state due mainly to a high level of baseline SOC stocks. ?? 2010 Elsevier B.V.

  3. An OCP Compliant Network Adapter for GALS-based SoC Design Using the MANGO Network-on-Chip

    DEFF Research Database (Denmark)

    Bjerregaard, Tobias; Mahadevan, Shankar; Olsen, Rasmus Grøndahl

    2005-01-01

    decouples communication and computation, providing memory-mapped OCP transactions based on primitive message-passing services of the network. Also, it facilitates GALS-type systems, by adapting to the clockless network. This helps leverage a modular SoC design flow. We evaluate performance and cost of 0......The demand for IP reuse and system level scalability in System-on-Chip (SoC) designs is growing. Network-onchip (NoC) constitutes a viable solution space to emerging SoC design challenges. In this paper we describe an OCP compliant network adapter (NA) architecture for the MANGO NoC. The NA...

  4. The ubiquitin ligase Cullin5(SOCS2) regulates NDR1/STK38 stability and NF-κB transactivation

    DEFF Research Database (Denmark)

    Paul, Indranil; Batth, Tanveer S; Iglesias-Gato, Diego

    2017-01-01

    SOCS2 is a pleiotropic E3 ligase. Its deficiency is associated with gigantism and organismal lethality upon inflammatory challenge. However, mechanistic understanding of SOCS2 function is dismal due to our unawareness of its protein substrates. We performed a mass spectrometry based proteomic...... show that SOCS2-deficiency is pro-inflammatory and negatively correlates with NDR1 and nuclear p65 levels. Lastly, we provide evidence to suggest that NDR1 acts as an oncogene in prostate cancer. To the best of our knowledge, this is the first report of an identified E3 ligase for NDR1. These results...

  5. Multiscale approach to the predictability of earthquakes and of synthetic SOC sequences

    Science.gov (United States)

    Peresan, A.; Panza, G. F.

    2003-04-01

    The power-law scaling expressed by the Gutenberg-Richter (GR) law is the main argument in favour of the Self-Organised Criticality (SOC) of seismic phenomena. Nevertheless the limits of validity of the GR law and the phenomenology reproduced by the SOC models, as well as their consequences for earthquake predictability, still remain quite undefined. According to the Multiscale Seismicity (MS) model, the GR law describes adequately only the ensemble of earthquakes that are geometrically small with respect to the dimensions of the analysed region. The MS model and its implications for intermediate-term medium-range earthquake predictions are thus examined, considering both the seismicity observed in the Italian territory and the synthetic sequences of events generated by a SOC model. The predictability of the large events is evaluated by means of the algorithms CN and M8, based on a quantitative analysis of the seismic flow within a delimited region, which allow for the prediction of the earthquakes with magnitude greater than a fixed threshold Mo. Considering the application of CN and M8 to the Italian territory, we show that, in agreement with the MS model, these algorithms make use of the information carried by small and moderate earthquakes, following the GR law, to predict the strong earthquakes, which are infrequent and often arbitrarily considered characteristic events inside the regions delimited for prediction purposes. Similarly, the application of the algorithm CN for the prediction of the largest events in the synthetic SOC sequences, indicates that a certain predictability can be attained, when the MS model is taken into account. These results suggest that the similarity between the seismic flow and the SOC sequences goes beyond the average features of scale-invariance. In fact, while the GR law describes an average feature of seismicity, CN algorithm is checking for the deviations from such trend, which may characterise the sequence of events before the

  6. The Meanings of Astronomical Observation: An Analysis on the Basis of Relationship with Knowledge. (Spanish Title: Los Sentidos de la Observación Astronómica: un Análisis sobre la Base de la Relación con el Saber.) Os Sentidos da Observação Astronômica: Uma Análise com Base na Relação com o Saber

    Science.gov (United States)

    Klein, Alberto Eduardo; de Mello Arruda, Sergio; Meneghello Passos, Marinez; Vinicius Domenes Zapparoli, Ferdinando

    2010-12-01

    This article presents results of a research which aimed to understand the meanings that people construct for astronomical observation. The subjects, students and school teachers, initially received some instruction on how to view astronomical objects through the telescope. After the observation was realized, they were interviewed. The data analysis allowed the creation of 12 categories, later interpreted on the basis of relationship with knowledge (relation to the world, with himself and with others), as presented by Bernard Charlot. Este artículo presenta los resultados de una investigación que tuvo como objetivo comprender los sentidos que las personas construyen para la observación astronómica. Los sujetos, los estudiantes y maestros de escuela, recibieron inicialmente algunas instrucciones sobre cómo ver los objetos astronómicos a través del telescopio. Al término de la observación, fueron entrevistados. El análisis de datos permitió la creación de 12 categorías que más tarde fueron interpretadas sobre la base de la relación con el conocimiento (relación con el mundo, consigo mismo y con los demás), tal como presentado por Bernard Charlot. Este artigo apresenta resultados de uma pesquisa que objetivou entender quais os sentidos que as pessoas constroem para a observação astronômica. Os sujeitos da pesquisa, estudantes e professores do ensino médio, receberam inicialmente alguma instrução sobre como visualizar os objetos astronômicos através do telescópio. Após a realização da observação, eles foram entrevistados. A análise dos dados permitiu a elaboração de 12 categorias que foram posteriormente interpretadas com base nas relações com o saber (relação com o mundo, consigo mesmo e com o outro), conforme apresentadas por Bernard Charlot.

  7. The fate of SOC during the processes of water erosion and subsequent deposition: a field study.

    Science.gov (United States)

    van Hemelryck, H.; Govers, G.; van Oost, K.; Merckx, R.

    2009-04-01

    Globally soils are the largest terrestrial pool of carbon (C). A relatively small increase or decrease in soil carbon content due to changes in land use or management practices could therefore result in a significant net exchange of C between the soil C reservoir and the atmosphere. As such, the geomorphic processes of water and tillage erosion have been identified to significantly impact on this large pool of soil organic carbon (SOC). Soil erosion, transport and deposition not only result in redistribution of sediments and associated carbon within a landscape, but also affect the exchange of C between the pedosphere and the atmosphere. The direction and magnitude of an erosion-induced change in the global C balance is however a topic of much debate as opposing processes interact: i) At eroding sites a net uptake of C could be the result of reduced respiration rates and continued inputs of newly produced carbon. ii) Colluvial deposition of eroded sediment and SOC leads to the burial of the original topsoil and this may constrain the decomposition of its containing SOC. iii) Eroded sediment could be transported to distal depositional environments or fluvial systems where it will either be conserved or become rapidly mineralized. iv) Increased emission of CO2 due to erosion may result from the disruptive energy of erosive forces causing the breakdown of aggregates and exposing previously protected SOC to microbial decomposition. The above-mentioned processes show a large spatial and temporal variability and assessing their impact requires an integrated modeling approach. However uncertainties about the basic processes that accompany SOC displacement are still large. This study focuses on one of these large information gaps: the fate of eroded and subsequently deposited SOC. A preceding experimental study (Van Hemelryck et al., 2008) was used to identify controlling factors (erosional intensity, changes in soil structure,…). However this experimental research

  8. Numerical Simulations of Solar Spicule Jets at a Magnetic Null-Point

    Science.gov (United States)

    Smirnova, V.; Konkol, P. M.; Solov'ev, A. A.; Murawski, K.

    2016-11-01

    Two-dimensional numerical simulations of jet-like structures in the solar atmosphere are performed. These structures result from a pressure pulse that is launched at the null point of a potential magnetic arcade. The plasma jet exhibits a double structure with two components: (a) dense, cool, and short vertical stream and (b) a less dense, hot and tall part of the jet. The upper part of the hot and tall jet may represent a direct response of the system to the pressure pulse launched at the null point, and the second, slower cool and dense part of the jet is formed later through the stretching up of the stream as a result of plasma evacuation from the top of the magnetic arcade. Numerical results show that jet-like structures mimic some properties of both type I and type II spicules, according to the classification provided by De Pontieu et al. ( Publ. Astron. Soc. Japan 59, S655, 2007).

  9. The Question and Prospect for the Development of SOC%开发SOC面临的问题及发展展望

    Institute of Scientific and Technical Information of China (English)

    于宗光

    2001-01-01

    The basic concept of SOC is reviewed first. The various questions for the research of SOC are analyzed. The developing strategy of SOC is presented.%在阐述SOC发展背景的基础上,分析了SOC发展面临的各种问题,并提出了我国SOC发展的策略。

  10. Using 137Cs to study spatial patterns of soil erosion and soil organic carbon (SOC) in an agricultural catchment of the typical black soil region, Northeast China.

    Science.gov (United States)

    Fang, Haiyan; Li, Qiuyan; Sun, Liying; Cai, Qiangguo

    2012-10-01

    Understanding the spatial pattern of soil organic carbon (SOC) is of great importance because of global environmental concerns. Soil erosion and its subsequent redistribution contribute significantly to the redistribution of SOC in agricultural ecosystems. This study investigated the relationships between (137)Cs and SOC over an agricultural landscape, and SOC redistribution was conducted for an agricultural catchment of the black soil region in Northeast China. The spatial patterns of (137)Cs and SOC were greatly affected by the established shelterbelts and the developed ephemeral gullies. (137)Cs were significantly correlated with SOC when (137)Cs were >2000 Bq m(-2), while no relation was observed between them when (137)Cs were SOC, landscape position and management induced their spatial difference of (137)Cs and SOC. Using (137)Cs technique to directly study SOC dynamics must be cautious in the black soils. The net SOC loss rate across the entire catchment during 1954-2010 was 92.8 kg ha(-1) yr(-1), with around 42% of the eroded SOC being redeposited within the catchment. Such information can help guide shelterbelt establishment or other land management to reduce SOC loss in the agricultural ecosystems.

  11. Péndulos astronómicos y cronómetros marinos de la armada: el observatorio de San Fernando y los antecedentes del patrón nacional de tiempo (1753-1957

    Directory of Open Access Journals (Sweden)

    González González, Francisco José

    1998-06-01

    Full Text Available This article is a brief review on the precision clocks in use by the Spanish Navy during the XVIII, XIX and XX centuries. It deals with the introduction in Spain of marine chronometers needed for the application of the new techniques of astronomical navigation and also, with the evolution of the methods for time keeping and determination by astronomical pendulum clocks. Both facts placed the Navy and its Observatory in a good starting position for future activity in the field of the scientific study of time in our country.

    Este artículo presenta un breve estudio sobre los relojes de precisión usados por la Armada española durante los siglos XVIII, XIX y XX. Se trata, por una parte, sobre la introducción en España de los cronómetros marinos, necesarios para la aplicación de las nuevas técnicas de navegación astronómica. Se estudia, además, la evolución del sistema de determinación y conservación de la hora mediante péndulos astronómicos, origen del servicio horario del Observatorio de San Femando. Ambas vertientes sitúan a la Marina, y a su Observatorio, en un lugar preferente en los trabajos relacionados con el cómputo científico del tiempo en nuestro país.

  12. Effects of land use change and management on SOC and soil quality in Mediterranean rangelands areas

    Science.gov (United States)

    Parras-Alcántara, Luis; Lozano-García, Beatriz; Requejo, Ana; Zornoza, Raúl

    2017-04-01

    INTRODUCTION Rangelands in the Iberian Peninsula occupy more than 90,000 km2. These rangelands were created from the former Mediterranean oak forests, mainly composed of holm oak and cork oak (Quercus ilex rotundifolia and Quercus suber), by clear-cutting shrubs, removing selected trees and cultivating. These man-made landscapes are called 'dehesas' in Spain and 'montados' in Portugal. Between 1955 and 1981, more than 5,000 km2 of dehesas was converted from pastureland to cultivated land. This process has been accelerated since 1986 owing to subsidies from the European Common Agricultural Policy (Parras-Alcántara et al., 2015a). The role that natural rangelands play in the global carbon cycle is extremely important, accounting for 10-30% of the world's total soil organic carbon (SOC), in addition, SOC concentration is closely related to soil quality and vegetation productivity (Brevik, 2012). Therefore, to study the land use and management changes is important, particularly in Mediterranean soils, as they are characterized by low organic carbon content, furthermore, the continuous use of ploughing for grain production is the principal cause of soil degradation. Therefore, land use decisions and management systems can increase or decrease SOC content and stock (Corral-Fernández et al., 2013; Parras-Alcántara et al., 2014, 2015a and 2015b; Parras-Alcántara and Lozano-García, 2014) MATERIAL AND METHODS A field study was conducted to determine the land use change (Mediterranean evergreen oak woodland to olive grove and cereal, all of them managed under conventional tillage and under conservationist practices) effects on SOC stocks and the soil quality (Stratification Ratio) in Los Pedroches valley, southern Spain. RESULTS Results for the present study indicate that management practices had little effect on SOC storage in dehesas. The stratification ratio was >2 both under conventional tillage and under organic farming, so, soils under dehesa had high quality

  13. Effect of crop residue incorporation on soil organic carbon (SOC) and greenhouse gas (GHG) emissions in European agricultural soils

    Science.gov (United States)

    Lehtinen, Taru; Schlatter, Norman; Baumgarten, Andreas; Bechini, Luca; Krüger, Janine; Grignani, Carlo; Zavattaro, Laura; Costamagna, Chiara; Spiegel, Heide

    2014-05-01

    Soil organic matter (SOM) improves soil physical (e.g. increased aggregate stability), chemical (e.g. cation exchange capacity) and biological (e.g. biodiversity, earthworms) properties. The sequestration of soil organic carbon (SOC) may mitigate climate change. However, as much as 25-75% of the initial SOC in world agricultural soils may have been lost due to intensive agriculture (Lal, 2013). The European Commission has described the decline of organic matter (OM) as one of the major threats to soils (COM(2006) 231). Incorporation of crop residues may be a sustainable and cost-efficient management practice to maintain the SOC levels and to increase soil fertility in European agricultural soils. Especially Mediterranean soils that have low initial SOC concentrations, and areas where stockless croplands predominate may be suitable for crop residue incorporation. In this study, we aim to quantify the effects of crop residue incorporation on SOC and GHG emissions (CO2 and N2O) in different environmental zones (ENZs, Metzger et al., 2005) in Europe. Response ratios for SOC and GHG emissions were calculated from pairwise comparisons between crop residue incorporation and removal. Specifically, we investigated whether ENZs, clay content and experiment duration influence the response ratios. In addition, we studied how response ratios of SOM and crop yields were correlated. A total of 718 response ratios (RR) were derived from a total of 39 publications, representing 50 experiments (46 field and 4 laboratory) and 15 countries. The SOC concentrations and stocks increased by approximately 10% following crop residue incorporation. In contrast, CO2 emissions were approximately six times and N2O emissions 12 times higher following crop residue incorporation. The effect of ENZ on the response ratios was not significant. For SOC concentration, the >35% clay content had significantly approximately 8% higher response ratios compared to 18-35% clay content. As the duration of the

  14. Association of primary biliary cirrhosis with variants in the CLEC16A, SOCS1, SPIB and SIAE immunomodulatory genes

    Science.gov (United States)

    Hirschfield, GM; Xie, G; Lu, E; Sun, Y; Juran, BD; Chellappa, V; Coltescu, C; Mason, AL; Milkiewicz, P; Myers, RP; Odin, JA; Luketic, VA; Bacon, B; Bodenheimer, H; Liakina, V; Vincent, C; Levy, C; Pillai, S; Lazaridis, KN; Amos, CI; Siminovitch, KA

    2012-01-01

    We fine mapped two primary biliary cirrhosis (PBC) risk loci, CLEC16A (C-type lectin domain family 16 member A)–suppressor of cytokine signaling 1 (SOCS1) and Spi-B protein (SPIB) and sequenced a locus, sialic acid acetylesterase (SIAE), proposed to harbor autoimmunity-associated mutations. In all, 1450 PBC cases and 2957 healthy controls were genotyped for 84 single-nucleotide polymorphisms (SNPs) across the CLEC16A-SOCS1 and SPIB loci. All 10 exons of the SIAE gene were resequenced in 381 cases and point substitutions of unknown significance assayed for activity and secretion. Fine mapping identified 26 SNPs across the CLEC16A-SOCS1 and 11 SNPs across the SPIB locus with significant association to PBC, the strongest signals at the CLEC16A-SOCS1 locus emanating from a SOCS1 intergenic SNP (rs243325; P = 9.91 × 10−9) and at the SPIB locus from a SPIB intronic SNP (rs34944112; P = 3.65 × 10−9). Among the associated SNPs at the CLEC16A-SOCS1 locus, two within the CLEC16A gene as well as one SOCS1 SNP (rs243325) remained significant after conditional logistic regression and contributed independently to risk. Sequencing of the SIAE gene and functional assays of newly identified variants revealed six patients with functional non-synonymous SIAE mutations (Fisher’s P = 9 × 10−4 vs controls) We demonstrate independent effects on risk of PBC for CLEC16A, SOCS1 and SPIB variants, while identifying functionally defective SIAE variants as potential factors in risk for PBC. PMID:22257840

  15. Change in sense of coherence (SOC) and symptoms of depression among old non-demented persons 12 months after hospitalization.

    Science.gov (United States)

    Helvik, Anne-Sofie; Engedal, Knut; Selbaek, Geir

    2013-01-01

    We studied whether SOC of older adults (≥65 years) without cognitive impairment had changed 1-year after medical hospitalization (T2) and to examine what factors were associated with the change. At baseline (T1) and (T2), the 13-item version of the SOC scale assessed coping, and the Hospital Anxiety and Depression (HAD) Scale assessed symptoms of depression and anxiety. The cognitive state was assessed by means of the mini-mental state examination (MMSE). Physical health was measured with the Charlson Index and functional status with Lawton and Brody's scales for physical self-maintenance (PSMS) and the instrumental activities of daily living (I-ADL). In all, 97 (51 men) persons with a mean age of 75.3 (SD 6.3) years and Mini Mental State Evaluation (MMSE) score of 28.0 (SD 1.6) participated. The SOC improved significantly from baseline to 1-year later (mean 76.5, SD 11.4 vs. mean 79.1, SD 9.1, p≤0.01). Improved SOC was associated with a low SOC at baseline and living without assistance during the study period. The prevalence of depression (HAD-D≥8) and the mean depression (HAD-D) score did not change between the first and second data collection (HAD-D≥8: 3.1% vs. 4.1% and HAD-D score: mean 1.8, SD 2.3 vs. mean 2.4, SD 2.4). However, an improved SOC and reduced anxiety symptoms at the second time point were associated with reduced HAD-D. The mean SOC improved 1-year after hospitalization. The symptoms of depression did not change, but reduction of symptoms of depression at the second time point was associated with improved SOC.

  16. Structure of the small outer capsid protein, Soc: a clamp for stabilizing capsids of T4-like phages.

    Science.gov (United States)

    Qin, Li; Fokine, Andrei; O'Donnell, Erin; Rao, Venigalla B; Rossmann, Michael G

    2010-01-29

    Many viruses need to stabilize their capsid structure against DNA pressure and for survival in hostile environments. The 9-kDa outer capsid protein (Soc) of bacteriophage T4, which stabilizes the virus, attaches to the capsid during the final stage of maturation. There are 870 Soc molecules that act as a "glue" between neighboring hexameric capsomers, forming a "cage" that stabilizes the T4 capsid against extremes of pH and temperature. Here we report a 1.9 A resolution crystal structure of Soc from the bacteriophage RB69, a close relative of T4. The RB69 crystal structure and a homology model of T4 Soc were fitted into the cryoelectron microscopy reconstruction of the T4 capsid. This established the region of Soc that interacts with the major capsid protein and suggested a mechanism, verified by extensive mutational and biochemical studies, for stabilization of the capsid in which the Soc trimers act as clamps between neighboring capsomers. The results demonstrate the factors involved in stabilizing not only the capsids of T4-like bacteriophages but also many other virus capsids.

  17. Astronomical Perception of the Secondary School's Students in São Paulo's State School in Suzano City. (Spanish Title: Percepción Astronómica de Alumnos de la Enseñanza Media de la Red Estatal de San Pablo en la Ciudad de Suzano.) Percepção Astronômica de um Grupo de Alunos do Ensino Médio da Rede Estadual de São Paulo da Cidade de Suzano

    Science.gov (United States)

    França de Oliveira, Edilene; Voelzke, Marcos Rincon; Amaral, Luis Henrique

    2007-12-01

    Although Astronomy is one of the oldest Sciences in the world and many of its concepts are popular, it is possible to observe that a major part of the students do not know about them. This work aims to analyse the basic knowledge of the secondary school's students of a state school in the city of Suzano, related to the astronomical phenomena, which surround them. It was carried out a questionnaire of multiple choice to 34 students from the first grade, night classes, of the state school Batista Renzi. From the sample, 34 students, only 29.4% of them could understand the succession of the days; 20.6% could explain the seasons of the year and 20.6% had some idea about celestial objects nearer to the Earth. In turn, 67.6% correctly classified the Sun as a star; 55.9% related the Big Bang to the origin of Universe; only 20.6% identified the light-year as an unit of distance and 32.4% recognized a falling star as a meteor. The actual analysis was expanded to more 310 students of other classes, grades and periods of the same school. In this first stage, it can be noted the students' little discernment of the astronomical events and mainly the great confusion about the appropriate meaning of popular astronomical terms. Aunque la Astronomía es una de las ciencias más antiguas de la humanidad y muchos de los conceptos astronómicos son populares, se observa que una parcela significativa de los estudiantes se encuentra al margen de estas informaciones. El presente trabajo pretende analizar el nivel de conocimiento básico de los alumnos de la Enseñanza Media de la Red Estatal de la ciudad de Suzano con relación a los fenómenos astronómicos que los rodean. Con este objetivo fue elaborado un formulario constando de preguntas de selección múltipla, aplicado en el primer año nocturno de la Escuela Estatal Batista Renzi. En un universo de 34 alumnos se constató que solamente 29,4% comprendían la sucesión de los días; 20,6% explicaron correctamente las estaciones del

  18. STAT3 and SOCS3 expression patterns during murine placenta development

    Directory of Open Access Journals (Sweden)

    S. San Martin

    2013-06-01

    Full Text Available Signal transducers and activators of transcription 3 (Stat3 has been identified as an important signal transducer in the invasive phenotype of the trophoblasts cells in in vitro studies. However, the in situ distribution and patterns of expression of this molecule in trophoblast cells during the development of the placenta are still under-elucidated. Mice uteri of gestational ages between 7 and 14 days of pregnancy (dop were fixed in methacarn and processed with immunoperoxidase techniques for detection of Stat3 and its phosphorylation at serine (p-ser727 residues, as well as the suppressor of cytokine signaling 3 (Socs3 expression. Stat3 was observed at 7 through 9 dop in both the antimesometrial and mesometrial deciduas, while continued immunoreactivity between 10 and 13 dop was seen only in the mesometrial decidua. In the placenta, Stat3 was detected in the cytotrophoblast cells of labyrinth and giant trophoblast cells between 10 and 14 dop. Immunoreactivity for Stat3 was also seen in trophoblast cells surrounding the maternal blood vessels. On days 10 and 11 of pregnancy, p-ser727 was detectable in the mesometrial decidua and in giant trophoblasts, while during 12-14 dop in the spongiotrophoblast region. In addition, Socs3 was immunodetected in maternal and placental tissues, principally in the giant trophoblast cells during the whole period of the study. The present in situ study shows the distribution of Stat3, its serine activation and Socs3 in different maternal and fetal compartments during murine placental development, thus further supporting the idea that they play a role during physiological placentation in mice. 

  19. Reduced expression of TAC1, PENK and SOCS2 in Hcrtr-2 mutated narcoleptic dog brain

    Directory of Open Access Journals (Sweden)

    Mignot Emmanuel

    2007-05-01

    Full Text Available Abstract Background Narcolepsy causes dramatic behavioral alterations in both humans and dogs, with excessive sleepiness and cataplexy triggered by emotional stimuli. Deficiencies in the hypocretin system are well established as the origin of the condition; both from studies in humans who lack the hypocretin ligand (HCRT and in dogs with a mutation in hypocretin receptor 2 (HCRTR2. However, little is known about molecular alterations downstream of the hypocretin signals. Results By using microarray technology we have screened the expression of 29760 genes in the brains of Doberman dogs with a heritable form of narcolepsy (homozygous for the canarc-1 [HCRTR-2-2] mutation, and their unaffected heterozygous siblings. We identified two neuropeptide precursor molecules, Tachykinin precursor 1 (TAC1 and Proenkephalin (PENK, that together with Suppressor of cytokine signaling 2 (SOCS2, showed reduced expression in narcoleptic brains. The difference was particularly pronounced in the amygdala, where mRNA levels of PENK were 6.2 fold lower in narcoleptic dogs than in heterozygous siblings, and TAC1 and SOCS2 showed 4.4 fold and 2.8 fold decrease in expression, respectively. The results obtained from microarray experiments were confirmed by real-time RT-PCR. Interestingly, it was previously shown that a single dose of amphetamine-like stimulants able to increase wakefulness in the dogs, also produce an increase in the expression of both TAC1 and PENK in mice. Conclusion These results suggest that TAC1, PENK and SOCS2 might be intimately connected with the excessive daytime sleepiness not only in dogs, but also in other species, possibly including humans.

  20. Study of Reversible Logic Synthesis with Application in SOC: A Review

    Science.gov (United States)

    Sharma, Chinmay; Pahuja, Hitesh; Dadhwal, Mandeep; Singh, Balwinder

    2017-08-01

    The prime concern in today’s SOC designs is the power dissipation which increases with technology scaling. The reversible logic possesses very high potential in reducing power dissipation in these designs. It finds its application in latest research fields such as DNA computing, quantum computing, ultra-low power CMOS design and nanotechnology. The reversible circuits can be easily designed using the conventional CMOS technology at a cost of a garbage output which maintains the reversibility. The purpose of this paper is to provide an overview of the developments that have occurred till date in this concept and how the new reversible logic gates are used to design the logic functions.

  1. Metamodeling-driven IP reuse for SoC integration and microprocessor design

    CERN Document Server

    Mathaikutty, Deepak A

    2009-01-01

    This cutting-edge resource offers you an in-depth understanding of metamodeling approaches for the reuse of intellectual properties (IPs) in the form of reusable design or verification components. The books covers the essential issues associated with fast and effective integration of reusable design components into a system-on-a-chip (SoC) to achieve faster design turn-around time. Moreover, it addresses key factors related to the use of reusable verification IPs for a "write once, use many times" verification strategy - another effective approach that can attain a faster product design cycle.

  2. Hardware-Software Co-implementation of H.264 Decoder in SoC

    Institute of Scientific and Technical Information of China (English)

    YANG Yu-hong; ZHANG Wen-jun; XIONG Lian-xue; RAO Zhen-ning

    2006-01-01

    With the increasing demand for flexible and efficient implementation of image and video processing algorithms, there should be a good tradeoff between hardware and software design method. This paper utilized the HW-SW codesign method to implement the H. 264 decoder in an SoC with an ARM core, a multimedia processor and a deblocking filter coprocessor. For the parallel processing features of the multimedia processor, clock cycles of decoding process can be dramatically reduced. And the hardware dedicated deblocking filter coprocessor can improve the efficiency a lot. With maximum clock frequency of 150 MHz, the whole system can achieve real time processing speed and flexibility.

  3. Towards closed-loop neuromodulation: a wireless miniaturized neural implant SoC

    Science.gov (United States)

    Liu, Wentai; Wang, Po-Min; Lo, Yi-Kai

    2017-05-01

    This work reports a platform technology toward the development of closed-loop neuromodulation. A neural implant based on the SoC developed in our laboratory is used as an example to illustrate the necessary functionalities for the efficacious implantable system. We also present an example of using the system to investigate the epidural stimulation for partial motor function recovery after spinal cord injury in a rat model. This hardware-software co-design tool demonstrate its promising potential towards an effective closed-loop neuromodulation for various biomedical applications.

  4. Wrapper/TAM Co-Optimization and constrained Test Scheduling for SOCs Using Rectangle Bin Packing

    CERN Document Server

    Babu, Hafiz Md Hasan; Karim, Muhammad Rezaul; Mahmud, Abdullah Al; Islam, Md Saiful

    2010-01-01

    This paper describes an integrated framework for SOC test automation. This framework is based on a new approach for Wrapper/TAM co-optimization based on rectangle packing considering the diagonal length of the rectangles to emphasize on both TAM widths required by a core and its corresponding testing time .In this paper, an efficient algorithm has been proposed to construct wrappers that reduce testing time for cores. Rectangle packing has been used to develop an integrated scheduling algorithm that incorporates power constraints in the test schedule. The test power consumption is important to consider since exceeding the system's power limit might damage the system.

  5. Behavior data of battery and battery pack SOC estimation under different working conditions.

    Science.gov (United States)

    Zhang, Xu; Wang, Yujie; Yang, Duo; Chen, Zonghai

    2016-12-01

    This article provides the dataset of operating conditions of battery behavior. The constant current condition and the dynamic stress test (DST) condition were carried out to analyze the battery discharging and charging features. The datasets were achieved at room temperature, in April, 2016. The shared data contributes to clarify the battery pack state-of-charge (SOC) and the battery inconsistency, which is also shown in the article of "An on-line estimation of battery pack parameters and state-of-charge using dual filters based on pack model" (X. Zhang, Y. Wang, D. Yang, et al., 2016) [1].

  6. Real-time Face Detection and Tracking Using Haar Classifier on SoC

    OpenAIRE

    Rajashree Tripathy; R N Daschoudhury

    2014-01-01

    In this paper we intend to Implement a real time Face detection and tracking the head poses position from high definition video using Haar Classifier through Raspberry Pi BCM2835 CPU processor which is a combination of SoC with GPU based Architecture. OV5647 CMOS Image sensor with 5-megapixel used for obtaining high definition video H.264 video data via GPU’s hardware video decoder to improve the playback of H.264 Video data supporting from 1080p at 30fps with complete user control over fo...

  7. Suppressor of Cytokine Signaling (SOCS 5 utilises distinct domains for regulation of JAK1 and interaction with the adaptor protein Shc-1.

    Directory of Open Access Journals (Sweden)

    Edmond M Linossi

    Full Text Available Suppressor of Cytokine Signaling (SOCS5 is thought to act as a tumour suppressor through negative regulation of JAK/STAT and epidermal growth factor (EGF signaling. However, the mechanism/s by which SOCS5 acts on these two distinct pathways is unclear. We show for the first time that SOCS5 can interact directly with JAK via a unique, conserved region in its N-terminus, which we have termed the JAK interaction region (JIR. Co-expression of SOCS5 was able to specifically reduce JAK1 and JAK2 (but not JAK3 or TYK2 autophosphorylation and this function required both the conserved JIR and additional sequences within the long SOCS5 N-terminal region. We further demonstrate that SOCS5 can directly inhibit JAK1 kinase activity, although its mechanism of action appears distinct from that of SOCS1 and SOCS3. In addition, we identify phosphoTyr317 in Shc-1 as a high-affinity substrate for the SOCS5-SH2 domain and suggest that SOCS5 may negatively regulate EGF and growth factor-driven Shc-1 signaling by binding to this site. These findings suggest that different domains in SOCS5 contribute to two distinct mechanisms for regulation of cytokine and growth factor signaling.

  8. Expression of SOCS1 and the downstream targets of its putative tumor suppressor functions in prostate cancer.

    Science.gov (United States)

    Chevrier, Martin; Bobbala, Diwakar; Villalobos-Hernandez, Alberto; Khan, Md Gulam Musawwir; Ramanathan, Sheela; Saucier, Caroline; Ferbeyre, Gerardo; Geha, Sameh; Ilangumaran, Subburaj

    2017-02-24

    Suppressor of cytokine signaling 1 (SOCS1) is considered a tumor suppressor due to frequent epigenetic and micro-RNA-mediated repression of its gene expression in diverse cancers. In prostate cancer (PCa), elevated expression of miR-30d that targets SOCS1 mRNA is associated with increased risk of disease recurrence. SOCS1 can mediate its tumor suppressor functions by diverse mechanisms such as inhibiting the JAK-STAT signaling pathway, promoting the tumor suppressor functions of p53, attenuating MET receptor tyrosine kinase signaling and blocking the oncogenic potential of the cell cycle inhibitor p21(CIP1) (p21). Here, we studied the expression of SOCS1 and the downstream targets of its putative tumor suppressor functions (p53, MET and p21) in human PCa specimens to evaluate their significance as markers of disease prognosis. Tissue microarrays were constructed of 78 archived prostatectomy specimens that were grouped according to the recommendations of the International Society of Urological Pathology (ISUP) based on the Gleason patterns. SOCS1, p53, MET and p21 protein expression were evaluated by immunohistochemical staining alongside the common prostate cancer-related markers Ki67, prostein and androgen receptor. Statistical correlations between the staining intensities of these markers and ISUP grade groups, local invasion or lymph node metastasis were evaluated. SOCS1 showed diffuse staining in the prostatic epithelium. SOCS1 staining intensity correlated inversely with the ISUP grade groups (ρ = -0.4687, p <0.0001) and Ki67 (ρ = -0.2444, p = 0.031), and positively with prostein (ρ = 0.3511, p = 0.0016). Changes in SOCS1 levels did not significantly associate with those of p53, MET or p21. However, p21 positively correlated with androgen receptor expression (ρ = -0.1388, p = 0.0003). A subset of patients with regional lymph node metastasis, although small in number, showed reduced SOCS1 expression and increased expression of

  9. An ESL Approach for Energy Consumption Analysis of Cache Memories in SoC Platforms

    Directory of Open Access Journals (Sweden)

    Abel G. Silva-Filho

    2011-01-01

    Full Text Available The design of complex circuits as SoCs presents two great challenges to designers. One is the speeding up of system functionality modeling and the second is the implementation of the system in an architecture that meets performance and power consumption requirements. Thus, developing new high-level specification mechanisms for the reduction of the design effort with automatic architecture exploration is a necessity. This paper proposes an Electronic-System-Level (ESL approach for system modeling and cache energy consumption analysis of SoCs called PCacheEnergyAnalyzer. It uses as entry a high-level UML-2.0 profile model of the system and it generates a simulation model of a multicore platform that can be analyzed for cache tuning. PCacheEnergyAnalyzer performs static/dynamic energy consumption analysis of caches on platforms that may have different processors. Architecture exploration is achieved by letting designers choose different processors for platform generation and different mechanisms for cache optimization. PCacheEnergyAnalyzer has been validated with several applications of Mibench, Mediabench, and PowerStone benchmarks, and results show that it provides analysis with reduced simulation effort.

  10. Signaling via the CytoR/JAK/STAT/SOCS pathway: Emergence during evolution.

    Science.gov (United States)

    Liongue, Clifford; Taznin, Tarannum; Ward, Alister C

    2016-03-01

    Cell-cell signaling represents an essential hallmark of multicellular organisms, which necessarily require a means of communicating between different cell populations, particularly immune cells. Cytokine receptor signaling through the Janus kinase/Signal Transducer and Activator of Transcription/Suppressor of Cytokine Signaling (CytoR/JAK/STAT/SOCS) pathway embodies one important paradigm by which this is achieved. This pathway has been extensively studied in vertebrates and protostomes and shown to play fundamental roles in development and function of immune and other cells. However, our understanding of the origins of the individual pathway components and their assembly into a functional pathway has remained limited. This study examined the origins of each component of this pathway through bioinformatics analysis of key extant species. This has revealed step-wise accretion of individual components over a large evolutionary time-frame, but only in bilateria did a series of innovations allow their final coalescence to form a complete pathway. Assembly of the CytoR/JAK/STAT pathway has followed the retrograde model of pathway evolution, whereas addition of the SOCS component has adhered to the patchwork model.

  11. EtherBone - A Network Layer for the Wishbone SoC Bus

    CERN Document Server

    Kreider, M; Lewis, J; Włostowski, T; Serrano, J

    2011-01-01

    Today, there are several System on a Chip (SoC) bus systems. Typically, these buses are confined on-chip and rely on higher level components to communicate with the outside world. Taking these systems a step further, we see the possibility of extending the reach of the SoC bus to remote FPGAs or processors. This leads to the idea of the EtherBone (EB) core, which connects a Wishbone (WB) Ver. 4 Bus via a Gigabit Ethernet based network link to remote peripheral devices. EB acts as a transparent interconnect module towards attached WB Bus devices. Address information and data from one or more WB bus cycles is preceded with a descriptive header and encapsulated in a UDP/IP packet. Because of this standard compliance, EB is able to traverse Wide Area Networks and is therefore not bound to a geographic location. Due to the low level nature of the WB bus, EB provides a sound basis for remote hardware tools like a JTAG debugger, In-System-Programmer (ISP), boundary scan interface or logic analyser module. EB was de...

  12. Multi Resolution AHB Bus Tracer with Real Time Compression for SOC

    Directory of Open Access Journals (Sweden)

    J. Jagadish Reddy

    2013-01-01

    Full Text Available AMBA (Advanced Microcontroller based Bus Architecture consists of AHB, APB, ASB and AXI. In this project we are Tracing AHB (Advanced High performance Bus signals with Real time Compression and Multi-resolution Techniques. A simple transaction on the AHB consists of an address phase and a subsequent data phase. Access to the target device is controlled through a MUX , thereby admitting bus-access to one bus-master at a time. In AHB Tracer we have to Trace Address signals, Data signals and Control signals, we have to compress them depending on AHB protocols. A multi-resolution AHB on-chip bus tracer is named as SYS_HMRBT (AHB Multi-resolution Bus Tracer and is used for monitoring. The goal is to provide better compression quality and multiple resolution traces to meet the complex SoC debugging needs. Compressing all signals at cycle-accurate-level does not always meet the debugging needs. As SOCs become more complex, the transaction level debugging becomes increasingly important, since it helps designers focus on the functional behaviors, instead of interpreting complex signals. By using this SYS_HMRBT, we can achieve 79%-96% of compression depending on selected resolution mode. Tools Used for this Project are Modelsim for Simulation, and Xilinx ISE II for Synthesis

  13. Observation of self-organized criticality (SOC) behavior during edge biasing experiment on TEXTOR

    Energy Technology Data Exchange (ETDEWEB)

    Xu, Y.H.; Jachmich, S.; Weynants, R.R. [Ecole Royale Militaire/Koninklijke Militaire School, Laboratory for Plasma Physics, Euratom-Belgian State Association, Brussels, Belgium, Partner in the Trilateral Euregio Cluster (Belgium)

    2004-07-01

    The self-organized criticality (SOC) behavior of the edge plasma transport has been investigated using the fluctuation data measured in the plasma edge and the scrape-off layer of TEXTOR tokamak before and during the edge electrode biasing experiments. In the 'non-shear' discharge phase before biasing, both the potential and density fluctuations clearly exhibit some of the characteristics associated with SOC: (1) existence of f{sup -1} power-law dependence in the frequency spectrum, (2) slowly decaying long tails in the autocorrelation function, (3) values of Hurst parameters larger than 0.5 at all the detected radial locations, (4) non-Gaussian probability density function of fluctuations and (5) radial propagation of avalanche-like events in the edge plasma area. During the biasing phase, with the generation of an edge radial electric field E{sub r} and hence a sheared E{sub r} x B flow, the local turbulence is found to be well de-correlated by the E{sub r} x B velocity shear, consistent with theoretical predictions. Nevertheless, it is concomitantly found that the Hurst parameters are substantially enhanced in the negative flow shear region and in the scrape-off layer as well, which is contrary to theoretical expectation. Implication of these observations to our understanding of plasma transport mechanisms is discussed. (authors)

  14. Interaction Between Member LIGHT of TNF Superfamily and SOCS3, which Respond to Induce the Differentiation and Maturation of Dendritic Cell%SOCS3与LIGHT在诱导DC分化成熟中的相互作用

    Institute of Scientific and Technical Information of China (English)

    林苹; 张洁; 王琪; 陆燕蓉; 王修杰; 熊竹娟; 杨洪亮; 任婧婧

    2007-01-01

    目的 探讨SOCS3与LIGHT在刺激树突状细胞(DC)分化成熟过程中的相互作用.方法 用重组小鼠粒-巨噬细胞集落刺激因子(rmGM-CSF)、重组小鼠白细胞介素4(rmIL-4)体外诱导培养小鼠骨髓单核细胞产生骨髓来源树突状细胞(BMDC).RT-PCR、Western blot检测受LIGHT刺激后BMDC中SOCS3 mRNA及SOCS3蛋白表达的时间动力学;利用反义核苷酸技术抑制SOCS3的表达,通过流式细胞术测定BMDC 表面分子CD40、CD86的表达水平.结果 LIGHT刺激后,BMDC的SOCS3 mRNA水平有不同程度增高(P<0.05),并呈双峰度变化(分别出现在LIGHT刺激后2 h和10 h,增高幅度分别为92%和83%,其蛋白表达亦有所增加(LIGHT刺激24 h后表达量增加80%,P<0.05);反义寡核苷酸能阻断SOCS3的表达,其对mRNA和蛋白表达的抑制率分别为49%和45%;经反义寡核苷酸处理后的BMDC在LIGHT刺激下其CD40、CD86表达均升高(P<0.05).结论 LIGHT在刺激BMDC分化成熟过程中同时上调了SOCS3的表达;阻断SOCS3能使BMDC 对LIGHT 的反应更敏感,从而促使BMDC 成熟度更高;SOCS3对LIGHT 诱导的BMDC 分化成熟有负反馈调节作用.

  15. SOCS1基因SNPs快速筛查和等位基因频率估算%Study on Rapidly Screening SNPs of Cattle SOCS1 Gene and Estimating Allelic Frequencies

    Institute of Scientific and Technical Information of China (English)

    吴芸; 杨永强; 蒋自立; 陈瑶

    2012-01-01

    目的:试验旨在对务川黑牛SOCS1基因进行SNPs筛查.方法:选取务川黑牛为试验对象构建DNA池,设计2对引物分别扩增SOCS1基因的编码区和3’-UTR序列.切胶回收后对PCR产物进行双向测序.结果:结果表明,在牛中发现SOCS1基因SNPs位点.结论:SOCS1基因的编码区有1个SNPs,C645T为同义突变;3’-非翻译区(3'untranslated region,3’-UTR)有C815A和C900T 2个SNPs,3个SNPs等位基因频率分别为0.893 7、0.658 5和0.867 9.研究结果为下一步遗传效应分析及SOCS1基因对牛生长调控的功能研究提供一定试验基础.

  16. 芥菜开花整合子SOC1启动子的克隆及其与FLC、SVP蛋白互作的研究%Promoter Isolation of Flowering Signal Integrator SOC1 Gene and Its Interactions with FLC and SVP Proteins in Brassica juncea

    Institute of Scientific and Technical Information of China (English)

    陈娇; 赵夏云; 鲜登宇; 马关鹏; 谢婷; 王志敏; 宋明; 汤青林

    2015-01-01

    为了深入研究芥菜开花整合子SOC1基因的表达调控机制,利用染色体步移法从芥菜‘QJ’中克隆了SOC1编码区上游782 bp的启动子,并构建SOC1基因启动子的酵母表达载体pAbAi-SOC1,与蛋白表达载体pGADT7-FLC、pGADT7-SVP共转化酵母Y1HGold菌株.酵母单杂交表明:芥菜FLC和SVP蛋白均能与SOC1的启动子相互作用.进一步分析发现:SOC1启动子含3个CArG-box表达调控基序.分别亚克隆这3个基因片段(SOC1-1、SOC1-2和SOC1-3),并再次构建酵母重组质粒pAbAi-SOC1-1、pAbAi-SOC1-2和pAbAi-SOC1-3,与pGADT7-FLC、pGADT7-SVP分别融合到Y1HGold菌株.融合菌株均能在相应SD/-Leu/AbA培养基上生长,说明SOC1-1、SOC1-2和SOC1-3都能被芥菜FLC、SVP蛋白识别并结合.再次构建SOC1-1、SOC1-2、SOC1-3的CArG-box删除突变体及A-T互换突变体,则均不能与FLC、SVP蛋白互作.由此说明:SOC1-1、SOC1-2和SOC1-3的3个CArG-box基序确实能特异性识别FLC、SVP,发生DNA—蛋白相互作用.这为利用启动子调控SOC1基因的转录表达等深入研究奠定了理论基础.

  17. Influenza A virus inhibits type I IFN signaling via NF-kappaB-dependent induction of SOCS-3 expression.

    Directory of Open Access Journals (Sweden)

    Eva-K Pauli

    2008-11-01

    Full Text Available The type I interferon (IFN system is a first line of defense against viral infections. Viruses have developed various mechanisms to counteract this response. So far, the interferon antagonistic activity of influenza A viruses was mainly observed on the level of IFNbeta gene induction via action of the viral non-structural protein 1 (NS1. Here we present data indicating that influenza A viruses not only suppress IFNbeta gene induction but also inhibit type I IFN signaling through a mechanism involving induction of the suppressor of cytokine signaling-3 (SOCS-3 protein. Our study was based on the observation that in cells that were infected with influenza A virus and subsequently stimulated with IFNalpha/beta, phosphorylation of the signal transducer and activator of transcription protein 1 (STAT1 was strongly reduced. This impaired STAT1 activation was not due to the action of viral proteins but rather appeared to be induced by accumulation of viral 5' triphosphate RNA in the cell. SOCS proteins are potent endogenous inhibitors of Janus kinase (JAK/STAT signaling. Closer examination revealed that SOCS-3 but not SOCS-1 mRNA levels increase in an RNA- and nuclear factor kappa B (NF-kappaB-dependent but type I IFN-independent manner early in the viral replication cycle. This direct viral induction of SOCS-3 mRNA and protein expression appears to be relevant for suppression of the antiviral response since in SOCS-3 deficient cells a sustained phosphorylation of STAT1 correlated with elevated expression of type I IFN-dependent genes. As a consequence, progeny virus titers were reduced in SOCS-3 deficient cells or in cells were SOCS-3 expression was knocked-down by siRNA. These data provide the first evidence that influenza A viruses suppress type I IFN signaling on the level of JAK/STAT activation. The inhibitory effect is at least in part due to the induction of SOCS-3 gene expression, which results in an impaired antiviral response.

  18. Why is Antonovsky's sense of coherence not correlated to physical health? Analysing Antonovsky's 29-item Sense of Coherence Scale (SOC-29).

    Science.gov (United States)

    Flensborg-Madsen, Trine; Ventegodt, Søren; Merrick, Joav

    2005-09-14

    We have previously concluded that the use of the Antonovsky Sense of Coherence (SOC) scale was unable to document a predicted strong association between SOC and physical health. By way of statistical methods numerous studies have investigated the validity, reliability, and applicability of the SOC scale with positive results. However, this paper analyses whether the questions in the SOC scale actually represent the universe of factors necessary to describe the phenomenon of SOC, which we believe is an important supplement to the statistically means of investigating validity and reliability. In this paper we explore the idea, the concepts, the theory and the operationalization behind the SOC Scale. The conclusions are: 1) it seems that Antonovsky's basic idea of coherence, for which he coined the term sense of coherence, as the basis for the highly popular salutogenic orientation is outstandingly good, in spite of the lack of statistical evidence; 2) the chosen key explanatory concepts of comprehensibility, manageability, and meaning, seems to be a fair, although mental, conceptualization of this idea; 3) Antonovsky's theory was unfortunately much less clear, as Antonovsky assumed predictability to be very important for the sense of coherence, especially for comprehensibility and manageability. This notion of predictability leaves its footprints in his operationalization of SOC into the SOC Scale. Our analysis convinced us that the SOC scale is unlikely to be a fair materialization of the idea of coherence and thus unlikely to measure SOC correctly.

  19. Effects of different soil types in natural Mediterranean areas on soil organic carbon (SOC)

    Science.gov (United States)

    Requejo Silva, Ana; Lozano García, Beatriz; Parras Alcántara, Luis

    2017-04-01

    Effects of different soil types in natural Mediterranean areas on soil organic carbon (SOC) Ana Requejo1, Beatriz Lozano-García1, Luis Parras Alcántara1 1 Department of Agricultural Chemistry and Soil Science, Faculty of Science, Agrifood Campus of International Excellence - ceiA3, University of Córdoba, Spain. The carbon content of the atmosphere can be influenced by soils, since they can store carbon or emit large quantities of CO2. C sequestration into soils is one of the most important ecosystems services because of its role in climate regulation (IPPC, 2007). Thereof, agriculture and forestry are the only activities that can contribute to C sequestration through photosynthesis and its carbon incorporation into carbohydrates (Parras Alcántara et al., 2013). Dehesa is a multifunctional agro-sylvo-pastoral system and typical landscape of southern and central Spain and southern Portugal. It is an anthropogenic system dedicated to the combined production of black iberian pigs, a variety of foods, fuel, coal, and cork. Besides, it acts as well in the production of endangered species as wildlife habitat and as sustainable hunting areas. These dehesa areas are defined by a relationship between productivity and conservation of forest oaks, providing environmental benefits such as carbon capture and storage. The area focused in this study is the Cardeña-Montoro Nature Reserve, located within the Sierra Morena (Córdoba, South Spain). The most representative soils in Cardeña-Montoro Nature Reserve are Cambisols, Regosols, Leptosols and Fluvisols according to IUSS Working Group WRB (2006). They are characterized by a low fertility, poor physical conditions and marginal capacity for agricultural use, along with low organic matter content due to climate conditions (semiarid Mediterranean climate) and soil texture (sandy). Several studies have shown that land use affects the SOC concentration (Lozano-García et al., 2016; Khaledian et al., 2016). Based on this

  20. Em busca de uma simpatia universal: o entendimento do principado de Otávio Augusto a partir da obra Astronômicas de Marco Manílio (século I d.C.)

    OpenAIRE

    Oliveira, Rodrigo Santos Monteiro

    2014-01-01

    Marco Manílio, escritor do I século d.C., estrutura, a partir de sua obra intitulada Astronômicas, o universo. Seu manual, que aborda conceitos e temas que atualmente dividimos entre astrologia e astronomia, nos traz uma compreensão organizacional dos corpos celestes, além de uma explanação acerca das relações existentes entre eles. Tais relações não abrangem somente a porção que compreendemos como Céu, mas também influenciam na elaboração e ação da vida terrena, ou seja, astro...

  1. Regulation of neurotrophin receptor (Trk signaling: suppressor of cytokine signaling 2 (SOCS2 is a new player

    Directory of Open Access Journals (Sweden)

    Rachel eUren

    2014-05-01

    Full Text Available The classic neurotrophins Nerve Growth Factor (NGF, Brain Derived Neurotrophic Factor (BDNF and Neurotrophins NT-3 and NT-4 are well known to regulate various aspects of neuronal differentiation, survival and growth. They do this by binding to their cognate receptors, members of the Tropomyosin-related kinase (Trk receptor tyrosine kinase family, namely TrkA, TrkB and TrkC. These receptors are then internalized and localized to different cellular compartments, where signal transduction occurs. Conversely, members of the suppressor of cytokine signaling (SOCS family are best known as negative regulators of signaling via the JAK/STAT pathway. Some members of the family, and in particular SOCS2, have roles in the nervous system that at least partially overlap with that of neurotrophins, namely neuronal differentiation and neurite outgrowth. Recent evidence suggests that SOCS2 is a novel regulator of NGF signaling, altering TrkA cellular localization and downstream signaling to affect neurite growth but not neuronal survival. This review first discusses regulation of Trk receptor signaling, followed by the role of SOCS2 in the nervous system and finishes with a discussion of possible mechanisms by which SOCS2 may regulate TrkA function.

  2. A 0.7-V 17.4- μ W 3-lead wireless ECG SoC.

    Science.gov (United States)

    Khayatzadeh, Mahmood; Zhang, Xiaoyang; Tan, Jun; Liew, Wen-Sin; Lian, Yong

    2013-10-01

    This paper presents a fully integrated sub-1 V 3-lead wireless ECG System-on-Chip (SoC) for wireless body sensor network applications. The SoC includes a two-channel ECG front-end with a driven-right-leg circuit, an 8-bit SAR ADC, a custom-designed 16-bit microcontroller, two banks of 16 kb SRAM, and a MICS band transceiver. The microcontroller and SRAM blocks are able to operate at sub-/near-threshold regime for the best energy consumption. The proposed SoC has been implemented in a standard 0.13- μ m CMOS process. Measurement results show the microcontroller consumes only 2.62 pJ per instruction at 0.35 V . Both microcontroller and memory blocks are functional down to 0.25 V. The entire SoC is capable of working at single 0.7-V supply. At the best case, it consumes 17.4 μ W in heart rate detection mode and 74.8 μW in raw data acquisition mode under sampling rate of 500 Hz. This makes it one of the best ECG SoCs among state-of-the-art biomedical chips.

  3. Improved OCV Model of a Li-Ion NMC Battery for Online SOC Estimation Using the Extended Kalman Filter

    Directory of Open Access Journals (Sweden)

    Ines Baccouche

    2017-05-01

    Full Text Available Accurate modeling of the nonlinear relationship between the open circuit voltage (OCV and the state of charge (SOC is required for adaptive SOC estimation during the lithium-ion (Li-ion battery operation. Online SOC estimation should meet several constraints, such as the computational cost, the number of parameters, as well as the accuracy of the model. In this paper, these challenges are considered by proposing an improved simplified and accurate OCV model of a nickel manganese cobalt (NMC Li-ion battery, based on an empirical analytical characterization approach. In fact, composed of double exponential and simple quadratic functions containing only five parameters, the proposed model accurately follows the experimental curve with a minor fitting error of 1 mV. The model is also valid at a wide temperature range and takes into account the voltage hysteresis of the OCV. Using this model in SOC estimation by the extended Kalman filter (EKF contributes to minimizing the execution time and to reducing the SOC estimation error to only 3% compared to other existing models where the estimation error is about 5%. Experiments are also performed to prove that the proposed OCV model incorporated in the EKF estimator exhibits good reliability and precision under various loading profiles and temperatures.

  4. Algorithm & SoC design for automotive vision systems for smart safe driving system

    CERN Document Server

    Shin, Hyunchul

    2014-01-01

    An emerging trend in the automobile industry is its convergence with information technology (IT). Indeed, it has been estimated that almost 90% of new automobile technologies involve IT in some form. Smart driving technologies that improve safety as well as green fuel technologies are quite representative of the convergence between IT and automobiles. The smart driving technologies include three key elements: sensing of driving environments, detection of objects and potential hazards, and the generation of driving control signals including warning signals. Although radar-based systems are primarily used for sensing the driving environments, the camera has gained importance in advanced driver assistance systems(ADAS). This book covers system-on-a-chip (SoC) designs—including both algorithms and hardware—related with image sensing and object detection by using the camera for smart driving systems. It introduces a variety of algorithms such as lens correction, super resolution, image enhancement, and object ...

  5. Implementation of a Capacitor Less Low Dropout Voltage Regulator on Chip (SOC

    Directory of Open Access Journals (Sweden)

    Shailika Sharma

    2014-06-01

    Full Text Available — In this paper we have implemented a linear voltage low drop out regulator for efficient power management considering the fact in mind that voltage regulators provide a constant voltage supply to the circuits. We replace the common drain by common source pass element to improve efficiency and reduce the voltage drop across the device. This research paper includes the process to remove the external capacitor allowing for greater power system (soc application. A compensation scheme is presented that provides both a fast transient response and full range alternating current (ac stability from 0 to 50 mA load current even if the output load is as high as 100 pf. A 2.7-v capacitorless LDO voltage regulator with a power supply 3 v was designed with a dropout voltage of 300 mv.

  6. Mixed-signal methodology guide advanced methodology for AMS IP and SOC design, verification and implementation

    CERN Document Server

    Chen, Jess; Mar, Monte F; Nizic, Mladen; Bailey, Brian

    2012-01-01

    This Book, The Mixed-Signal Methodology Guide: Advanced Methodology For Ams Ip And Soc Design, Verification, And Implementation Provides A Broad Overview Of The Design, Verification And Implementation Methodologies Required For Today's Mixed-Signal Designs. The Book Covers Mixed-Signal Design Trends And Challenges, Abstraction Of Analog Using Behavioral Models, Assertion-Based Metric-Driven Verification Methodology Applied On Analog And Mixed-Signal And Verification Of Low Power Intent In Mixed-Signal Design. It Also Describes Methodology For Physical Implementation In Context Of Concurrent Mixed-Signal Design And For Handling Advanced Node Physical Effects. The Book Contains Many Practical Examples Of Models And Techniques. The Authors Believe It Should Serve As A Reference To Many Analog, Digital And Mixed-Signal Designers, Verification, Physical Implementation Engineers And Managers In Their Pursuit Of Information For A Better Methodology Required To Address The Challenges Of Modern Mixed-Signal Design.

  7. Verification and Diagnosis Infrastructure of SoC HDL-model

    CERN Document Server

    Hahanov, Vladimir; Litvinova, Eugenia; Chumachenko, Svetlana

    2012-01-01

    This article describes technology for diagnosing SoC HDL-models, based on transactional graph. Diagnosis method is focused to considerable decrease the time of fault detection and memory for storage of diagnosis matrix by means of forming ternary relations in the form of test, monitor, and functional component. The following problems are solved: creation of digital system model in the form of transaction graph and multi-tree of fault detection tables, as well as ternary matrices for activating functional components in tests, relative to the selected set of monitors; development of a method for analyzing the activation matrix to detect the faults with given depth and synthesizing logic functions for subsequent embedded hardware fault diagnosing.

  8. Reconfigurable Multiparameter Biosignal Acquisition SoC for Low Power Wearable Platform

    Directory of Open Access Journals (Sweden)

    Jongpal Kim

    2016-11-01

    Full Text Available A low power and low noise reconfigurable analog front-end (AFE system on a chip (SoC for biosignal acquisition is presented. The presented AFE can be reconfigured for use in electropotential, bioimpedance, electrochemical, and photoelectrical modes. The advanced healthcare services based on multiparameter physiological biosignals can be easily implemented with these multimodal and highly reconfigurable features of the proposed system. The reconfigurable gain and input referred noise of the core instrumentation amplifier block are 25 dB to 52 dB, and 1 μVRMS, respectively. The power consumption of the analog blocks in one readout channel is less than 52 μW. The reconfigurable capability among various modes of applications including electrocardiogram, blood glucose concentration, respiration, and photoplethysmography are shown experimentally.

  9. Reconfigurable Multiparameter Biosignal Acquisition SoC for Low Power Wearable Platform

    Science.gov (United States)

    Kim, Jongpal; Ko, Hyoungho

    2016-01-01

    A low power and low noise reconfigurable analog front-end (AFE) system on a chip (SoC) for biosignal acquisition is presented. The presented AFE can be reconfigured for use in electropotential, bioimpedance, electrochemical, and photoelectrical modes. The advanced healthcare services based on multiparameter physiological biosignals can be easily implemented with these multimodal and highly reconfigurable features of the proposed system. The reconfigurable gain and input referred noise of the core instrumentation amplifier block are 25 dB to 52 dB, and 1 μVRMS, respectively. The power consumption of the analog blocks in one readout channel is less than 52 μW. The reconfigurable capability among various modes of applications including electrocardiogram, blood glucose concentration, respiration, and photoplethysmography are shown experimentally. PMID:27898004

  10. SOC Synchronization Control Method of Electric Vehicles Considering Customers' Convenience for Suppression of System Frequency Fluctuation

    Science.gov (United States)

    Shimizu, Koichiro; Masuta, Taisuke; Ota, Yutaka; Yokoyama, Akihiko

    Nowadays, a large integration of photovoltaic and wind power generations causes an imbalance between supply and demand in power systems because their outputs are intermittent. To solve the mentioned problem, Vehicle-to-Grid (V2G), which is one of the smart grid technologies, has gained much attention. Under the concept of V2G, batteries of Electric Vehicles (EVs) can be used as Battery Storage Energy Systems (BESS) in the power system. In this paper, we are developing a new Load Frequency Control (LFC) method using EVs, which is named the State Of Charge (SOC) synchronization control. In the proposal control method, a number of EVs in the power system can be considered as one large-capacity BESS. Moreover, the EVs can be plugged-in/out whenever the users want to and can store the sufficient energy for the next trip at plug-out.

  11. A Robust and Power-Efficient SoC Implementation in 65 nm

    Institute of Scientific and Technical Information of China (English)

    Bin Xiao; Yi-Fu Zhang; Yan-Ping Gao; Liang Yang; Dong-Mei Wu; Bao-Xia Fan

    2013-01-01

    Godson2H is a complex SoC (System-on-Chip) of Godson series,which is a 117mm2,152 million transistors chip fabricated in 65 nm CMOS LP/GP process technology.It integrates a 1 GHz processor core and abundant high or low speed peripheral IO interfaces.To overcome on-chip-variation problems in deep submicron designs,many methods are adopted in clock tree,and PVT detectors are integrated for debug.To meet the low power constraints in different applications,most of state-of-the-art low power methods are used carefully,such as dynamic voltage and frequency scaling,power gating and aggressive multi-voltage design.

  12. Reconfigurable Multiparameter Biosignal Acquisition SoC for Low Power Wearable Platform.

    Science.gov (United States)

    Kim, Jongpal; Ko, Hyoungho

    2016-11-25

    A low power and low noise reconfigurable analog front-end (AFE) system on a chip (SoC) for biosignal acquisition is presented. The presented AFE can be reconfigured for use in electropotential, bioimpedance, electrochemical, and photoelectrical modes. The advanced healthcare services based on multiparameter physiological biosignals can be easily implemented with these multimodal and highly reconfigurable features of the proposed system. The reconfigurable gain and input referred noise of the core instrumentation amplifier block are 25 dB to 52 dB, and 1 μVRMS, respectively. The power consumption of the analog blocks in one readout channel is less than 52 μW. The reconfigurable capability among various modes of applications including electrocardiogram, blood glucose concentration, respiration, and photoplethysmography are shown experimentally.

  13. Soc stock in different forest-related land-uses in central Stara planina mountain, Bulgaria

    Directory of Open Access Journals (Sweden)

    Zhiyanski Miglena

    2009-01-01

    Full Text Available Forest conversions may lead to an accumulation of carbon in vegetation, but little is known about changes in soil C storage with establishment of plantation forests. Understanding these effects is important to addressing issues relevant to ecosystem function and productivity, and to global balance of carbon. The study investigated the effects of the created coniferous plantations on former beech and pasture sites on the soil organic carbon storage. The major forest-related land-uses in the high mountainous regions of central Stara Planina Mountain were investigated: mountainous pasture, coniferous plantations (planted on previous pasture and beech forests between four and five decades ago and natural beech forests. The experimental data of soil properties, conducted in 2005, 2006 and 2007, were used in determining the variations in organic carbon storage in forest litter and in mineral soil under different land-use patterns. At each site five representative soil profiles were opened and described giving a total 75 soil samples from the soil layers respectively at 0-10, 10-30 and 30-50 cm depth. A total of 55 samples from forest floor layers (Aol, Aof, Aoh and greensward were collected with 25:25 cm plastic frame. The main soil properties were determined in accordance with the standardized methods in the Laboratory of soil science at the Forest Research Institute - BAS. The IPCC Good Practice Guidance for Land Use, Land Use Change and Forestry was used to estimate the soil organic carbon stock in soil and litter. The results obtained showed that the SOC stock was quite similar among forest land-uses. The conversion of natural beech forests to coniferous plantations in studied region is related with slightly expressed decrease in soil carbon storage. The values of SOC stocks in 0-50 cm soil layer in these sites were 8.5 (±2.1 tones/ha for pine and 11.0 (±1.4 tones/ha for spruce, while under the natural beech forest it was 14.8 (±1.0 tones

  14. A new universal gate for low power SoC applications

    Indian Academy of Sciences (India)

    M Geetha Priya; K Baskaran

    2013-08-01

    This paper formulates a new design technique for an area and energy efficient Universal NAND gate. The proposed robust three transistors (3T) based NAND gate is just as effective for dynamic power control in CMOS VLSI circuits for System on Chip (SoC) applications. The 3T NAND gate is intuitively momentous and lead to better performance measures in terms of dynamic power, reduced area and high speed while maintaining comparable performance than the other available NAND gate logic structures. Simulation tests were performed by employing standard Berkeley Predictive Technology Model (BPTM) 22 nm, 45 nm and 90 nm process technologies. The experiment and simulation results show that, the proposed 3T NAND gate effectively outperforms the basic CMOS NAND gate with excellent driving capability and signal integrity with exact output logic levels.

  15. Vitamin D3 alters microglia immune activation by an IL-10 dependent SOCS3 mechanism.

    Science.gov (United States)

    Boontanrart, Mandy; Hall, Samuel D; Spanier, Justin A; Hayes, Colleen E; Olson, Julie K

    2016-03-15

    Microglia become activated immune cells during infection or disease in the central nervous system (CNS). However, the mechanisms that downregulate activated microglia to prevent immune-mediated damage are not completely understood. Vitamin D3 has been suggested to have immunomodulatory affects, and high levels of vitamin D3 have been correlated with a decreased risk for developing some neurological diseases. Recent studies have demonstrated the synthesis of active vitamin D3, 1,25-dihydroxyvitamin D3, within the CNS, but its cellular source and neuroprotective actions remain unknown. Therefore, we wanted to determine whether microglia can respond to vitamin D3 and whether vitamin D3 alters immune activation of microglia. We have previously shown that microglia become activated by IFNγ or LPS or by infection with virus to express pro-inflammatory cytokines, chemokines, and effector molecules. In this study, activated microglia increased the expression of the vitamin D receptor and Cyp27b1, which encodes the enzyme for converting vitamin D3 into its active form, thereby enhancing their responsiveness to vitamin D3. Most importantly, the activated microglia exposed to vitamin D3 had reduced expression of pro-inflammatory cytokines, IL-6, IL-12, and TNFα, and increased expression of IL-10. The reduction in pro-inflammatory cytokines was dependent on IL-10 induction of suppressor of cytokine signaling-3 (SOCS3). Therefore, vitamin D3 increases the expression of IL-10 creating a feedback loop via SOCS3 that downregulates the pro-inflammatory immune response by activated microglia which would likewise prevent immune mediated damage in the CNS.

  16. SOCS1 cooperates with FLT3-ITD in the development of myeloproliferative disease by promoting the escape from external cytokine control

    DEFF Research Database (Denmark)

    Reddy, P.N.G.; Serve, H.; Brandts, C.H.;

    2012-01-01

    tandem duplication (ITD), when localized to the biosynthetic compartment, aberrantly activates STAT5. Here, we show that one of the target genes induced by STAT5 is suppressor of cytokine signaling (SOCS)1 - a surprising finding for a known tumor suppressor. Although SOCS1 expression in murine bone...... marrow severely impaired cytokine-induced colony growth, it failed to inhibit FLT3-ITD-supported colony growth, indicating resistance of FLT3-ITD to SOCS1. In addition, SOCS1 coexpression did not affect FLT3-ITD-mediated signaling or proliferation. Importantly, SOCS1 coexpression inhibited interferon......-αand interferon-γ signaling and protected FLT3-ITD hematopoietic cells from interferon-mediated growth inhibitory effects. In a murine bone marrow transplantation model, the coexpression of SOCS1 and FLT3-ITD significantly shortened the latency of a myeloproliferative disease compared with FLT3-ITD alone (P

  17. SOCS-3 is involved in the downregulation of the acute insulin-like effects of growth hormone in rat adipocytes by inhibition of Jak2/IRS-1 signaling

    DEFF Research Database (Denmark)

    Ridderstråle, M; Amstrup, J; Hilton, D J;

    2003-01-01

    identified family of suppressors of cytokine signaling (SOCS) proteins in the transition between the refractory and the responsive states in rat adipocytes. The ability of GH to stimulate lipogenesis and tyrosine phosphorylation of the GH receptor (GHR), Janus kinase 2 (Jak2), insulin receptor substrate-1...... (IRS-1) and -2 (IRS-2) was greatly reduced in refractory as compared to responsive primary rat adipocytes. However, phosphorylation of Signal Transducer and Activator of Transcription 5 (Stat5) was not affected. SOCS-3 and CIS mRNA levels were significantly higher in refractory compared to responsive...... cells and could be induced by GH, whereas the level of SOCS-2 mRNA was unchanged. With overexpression of GHR, Jak2 and IRS-1 along with each of these SOCS proteins in human A293 cells, we could demonstrate that both SOCS-1 and SOCS-3 completely inhibited the GH-stimulated tyrosine phosphorylation of IRS...

  18. Expression and significance of SOCS3 in liver tissue of rats with severe acute pancreatitis complicated by liver injury

    Directory of Open Access Journals (Sweden)

    Bin WANG

    2012-11-01

    Full Text Available Objective  To investigate the expression and mechanism of action of suppressor of cytokine signaling 3 (SOCS3 in liver tissue of rats with experimental severe acute pancreatitis (SAP concurring with liver injury. Methods  The rat model of SAP was reproduced by retrograde injection of 4% sodium taurocholate into the biliopancreatic duct. Thirty-two male SD rats were randomly assigned into 4 groups (8 each: normal control group (NC, SAP 6h, 12h, and 18h groups. The levels of serum amylase (AMY, alanine aminotransferase (ALT and aspartate aminotransferase (AST were measured dynamically. The concentrations of IL -6 and IL -18 were determined by ELISA. The localization and expression of SOCS3 protein in liver were determined by immunohistochemical staining and Western blotting. Results  Compared with NC group, the serum levels of AMY, ALT and AST increased significantly in SAP groups (P < 0.05, and there was significant difference among SAP groups. The serum concentrations of IL-6 and IL-18 increased significantly in the SAP groups than in NC group (P < 0.05, and there was significant difference among SAP groups. Compared with NC group, the concentration of SOCS3 protein increased significantly in SAP groups, and increased gradually along with the increased duration of pancreatitis (P < 0.05. A minor expression of SOCS3 protein was found in NC group. The change in SOCS3 protein concentration was consistent with the severity of liver injury as well as the serum concentrations of IL-6 and IL-18. Conclusions  The inflammatory action induced by SAP concurring with liver injury may induce the expression of SOCS3 in liver tissue, and it may increase in intensity along with the severity of liver injury and inflammatory reaction. The mechanism may be attributed to a negative feedback regulation of the inflammatory action mediated by JAK/STAT pathway.

  19. Methylation of SOCS3 is inversely associated with metabolic syndrome in an epigenome-wide association study of obesity.

    Science.gov (United States)

    Ali, Omar; Cerjak, Diana; Kent, Jack W; James, Roland; Blangero, John; Carless, Melanie A; Zhang, Yi

    2016-09-01

    Epigenetic mechanisms, including DNA methylation, mediate the interaction between gene and environment and may play an important role in the obesity epidemic. We assessed the relationship between DNA methylation and obesity in peripheral blood mononuclear cells (PBMCs) at 485,000 CpG sites across the genome in family members (8-90 y of age) using a discovery cohort (192 individuals) and a validation cohort (1,052 individuals) of Northern European ancestry. After Bonferroni-correction (Pα=0.05 = 1.31 × 10(-7)) for genome-wide significance, we identified 3 loci, cg18181703 (SOCS3), cg04502490 (ZNF771), and cg02988947 (LIMD2), where methylation status was associated with body mass index percentile (BMI%), a clinical index for obesity in children, adolescents, and adults. These sites were also associated with multiple metabolic syndrome (MetS) traits, including central obesity, fat depots, insulin responsiveness, and plasma lipids. The SOCS3 methylation locus was also associated with the clinical definition of MetS. In the validation cohort, SOCS3 methylation status was found to be inversely associated with BMI% (P = 1.75 × 10(-6)), waist to height ratio (P = 4.18 × 10(-7)), triglycerides (P = 4.01 × 10(-4)), and MetS (P = 4.01 × 10(-7)), and positively correlated with HDL-c (P = 4.57 × 10(-8)). Functional analysis in a sub cohort (333 individuals) demonstrated SOCS3 methylation and gene expression in PBMCs were inversely correlated (P = 2.93 × 10(-4)) and expression of SOCS3 was positively correlated with status of MetS (P = 0.012). We conclude that epigenetic modulation of SOCS3, a gene involved in leptin and insulin signaling, may play an important role in obesity and MetS.

  20. Methylation of SOCS3 is inversely associated with metabolic syndrome in an epigenome-wide association study of obesity

    Science.gov (United States)

    Ali, Omar; Cerjak, Diana; Kent, Jack W.; James, Roland; Blangero, John; Carless, Melanie A.; Zhang, Yi

    2016-01-01

    ABSTRACT Epigenetic mechanisms, including DNA methylation, mediate the interaction between gene and environment and may play an important role in the obesity epidemic. We assessed the relationship between DNA methylation and obesity in peripheral blood mononuclear cells (PBMCs) at 485,000 CpG sites across the genome in family members (8-90 y of age) using a discovery cohort (192 individuals) and a validation cohort (1,052 individuals) of Northern European ancestry. After Bonferroni-correction (Pα=0.05 = 1.31 × 10−7) for genome-wide significance, we identified 3 loci, cg18181703 (SOCS3), cg04502490 (ZNF771), and cg02988947 (LIMD2), where methylation status was associated with body mass index percentile (BMI%), a clinical index for obesity in children, adolescents, and adults. These sites were also associated with multiple metabolic syndrome (MetS) traits, including central obesity, fat depots, insulin responsiveness, and plasma lipids. The SOCS3 methylation locus was also associated with the clinical definition of MetS. In the validation cohort, SOCS3 methylation status was found to be inversely associated with BMI% (P = 1.75 × 10−6), waist to height ratio (P = 4.18 × 10−7), triglycerides (P = 4.01 × 10−4), and MetS (P = 4.01 × 10−7), and positively correlated with HDL-c (P = 4.57 × 10−8). Functional analysis in a sub cohort (333 individuals) demonstrated SOCS3 methylation and gene expression in PBMCs were inversely correlated (P = 2.93 × 10−4) and expression of SOCS3 was positively correlated with status of MetS (P = 0.012). We conclude that epigenetic modulation of SOCS3, a gene involved in leptin and insulin signaling, may play an important role in obesity and MetS. PMID:27564309

  1. [Characteristics of Soil Respiration along Eroded Sloping Land with Different SOC Background on the Hilly Loess Plateau].

    Science.gov (United States)

    Chen, Gai; Xu, Ming-xiang; Zhang, Ya-feng; Wang, Chao-hua; Fan, Hui-min; Wang, Shan-shan

    2015-09-01

    This study aimed to characterize soil respiration along eroded sloping land at erosion and deposition area under different soil organic carbon(SOC) levels, and linked the relationship between soil respiration and soil temperature, soil moisture, SOC and slope position. Experiments were carried out in the plots of S type slopes include five different soil organic carbon levels in the Loess Hilly Region. The S type slopes were divided into control area at the top of the slope, erosion area at the middle of the slope and deposition area at the toe of the slope. We found that soil temperature had a greater impact on soil respiration in the deposition area, whereas soil moisture had a greater impact on soil respiration in the erosion area compared among control area, erosion area and deposition area. In addition, SOC was the most important factor affecting soil respiration, which can explain soil respiration variation 54. 72%, followed by soil moisture, slope position and soil temperature, which explain soil respiration variation 18. 86% , 16. 13% and 10. 29%, respectively. Soil respiration response to erosion showed obvious on-site and off-site effects along the eroded sloping land. Soil respiration in the erosion area was reduced by 21. 14% compared with control area, and soil respiration in the deposition area was increased by 21. 93% compared with control area. Erosion effect on source and sink of carbon emission was correlated with SOC content of the eroded sloping land. When SOC content was higher than 6. 82 g.kg-1, the slope. erosion tended to be a carbon sequestration process, and when SOC content was lower than 3.03 g.kg-1, the slope erosion tended to be a process of the carbon emission source. The model could reflect the relationship between soil respiration and independent variables of soil organic carbon content, soil temperature and moisture.

  2. A mixed SOC-turbulence model for nonlocal transport and Lévy-fractional Fokker–Planck equation

    Energy Technology Data Exchange (ETDEWEB)

    Milovanov, Alexander V. [ENEA National Laboratory, Centro Ricerche Frascati, I-00044 Frascati, Rome (Italy); Department of Space Plasma Physics, Space Research Institute, Russian Academy of Sciences, 117997 Moscow (Russian Federation); Juul Rasmussen, Jens [Physics Department, Technical University of Denmark, DK-2800 Kgs. Lyngby (Denmark)

    2014-04-01

    The phenomena of nonlocal transport in magnetically confined plasma are theoretically analyzed. A hybrid model is proposed, which brings together the notion of inverse energy cascade, typical of drift-wave- and two-dimensional fluid turbulence, and the ideas of avalanching behavior, associable with self-organized critical (SOC) behavior. Using statistical arguments, it is shown that an amplification mechanism is needed to introduce nonlocality into dynamics. We obtain a consistent derivation of nonlocal Fokker–Planck equation with space-fractional derivatives from a stochastic Markov process with the transition probabilities defined in reciprocal space. The hybrid model observes the Sparre Andersen universality and defines a new universality class of SOC.

  3. Analysis, design and implementation of analog/RF blocks suitable for a multi-band analog interface for CMOS SOCs

    OpenAIRE

    2008-01-01

    O desenvolvimento de tecnologias de integração para circuitos integrados junto com a demanda de cada vez mais processamento digital de sinais, como em sistemas de telecomunicações e aplicações SOC, resultaram na crescente necessidade de circuitos mistos em tecnologia CMOS integrados em um único chip. Em um trabalho anterior, a arquitetura de uma interface analógica para ser usada em aplicações SOC mistas foi desenvolvida e implementada. Basicamente esta interface é composta por uma célula ana...

  4. Multiple MIPS 4Kc cores based interrupt controller design and its implementation on HDTV SoC platform

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    A multiple MIPS 4Kc processor cores based interrupt processing system is introduced. The interrupt controller plays a key role in the high definition television (HDTV) system-on-a-chip (SoC) platform,especially when it is a multiple processor system. Based on a general introduction to the whole HDTV SoC platform, a layered interrupt controller and its implementation are discussed in detail. The proposed scheme was implemented in our FPGA verification board. The results indicate that our scheme is reliable and efficient. Meanwhile, as a functional intellectual property (IP), the interrupt controller has reusability and expandability with the layered structure.

  5. socs315 full course latest spring 2015 [ all discussions all homework all you decide and all quizes but no final

    OpenAIRE

    Laynebaril1

    2017-01-01

     socs315 full course latest spring 2015 [ all discussions all homework all you decide and all quizes but no final ] Click Link Below To Buy: http://hwcampus.com/shop/socs315-full-course-latest/   week 1 Marriage & Family Concerns (graded) Explain the concerns that someone might have when he or she is making choices to begin a relationship in a marriage and/or family life in our society. Is any of this uneasiness partly due to problems in society? Explain why and ho...

  6. Increased SOCS expression in peripheral blood mononuclear cells of end stage renal disease patients is related to inflammation and dialysis modality.

    Science.gov (United States)

    Rastmanesh, M Mehdi; Braam, Branko; Joles, Jaap A; Boer, Peter; Bluyssen, Hans A R

    2009-01-05

    Inflammation is a characteristic of cardiovascular disease and is increased in end-stage renal disease. Suppressors of cytokine signaling (SOCS) inhibit and reflect activation of intracellular inflammatory pathways. We hypothesized that SOCS expression in peripheral blood mononuclear cells of end stage renal disease patients is increased. Whether SOCS expression in peripheral blood mononuclear cells is related to inflammation, dialysis, and dialysis modality was investigated. Monocytes and lymphocytes were isolated from peripheral blood mononuclear cells of patients not on dialysis (n=8), on peritoneal dialysis (n=8), on hemodialysis (n=14) and of healthy control (n=15) subjects. SOCS expression was assessed by real-time quantitative PCR and plasma cytokines by ELISA. In end stage renal disease patients monocyte SOCS1, and lymphocyte SOCS1 and cytokine-inducible SH2 containing protein-1 (CIS-1) gene expression were increased along with increased plasma levels of interleukin (IL)-6, tumor necrosis factor (TNF)alpha ,and C-reactive protein (CRP). Monocyte SOCS1 correlated with IL-6. Lymphocyte CIS-1 was increased in non-dialysis and peritoneal dialysis but not in hemodialysis patients. Lymphocyte CIS-1 in peritoneal dialysis patients correlated with plasma TNFalpha. Despite the relatively low number of patients studied we observed increased expression of SOCS1 in both monocytes and lymphocytes, and of CIS-1 solely in lymphocytes of the patients. SOCS expression was related to increased systemic inflammation, illustrated by a significant correlation between monocyte SOCS1 and plasma IL-6. SOCS expression in peripheral blood mononuclear cells was also affected by hemodialysis, indicated by increased lymphocyte CIS-1 in non-dialysis and peritoneal dialysis but not in hemodialysis patients. We suggest that increased SOCS expression in peripheral blood mononuclear cells of end stage renal disease patients reflects whether and to which extent systemic inflammation

  7. MOF Crystal Chemistry Paving the Way to Gas Storage Needs: Aluminum-Based soc-MOF for CH4, O2, and CO2 Storage

    OpenAIRE

    Alezi, Dalal; Belmabkhout, Youssef; Suyetin, Mikhail; Bhatt, Prashant M.; Weseliński, Łukasz J.; Solovyeva, Vera; Adil, Karim; Spanopoulos, Ioannis; Trikalitis, Pantelis N.; Emwas, Abdul-Hamid; Eddaoudi, Mohamed

    2015-01-01

    The molecular building block approach was employed effectively to construct a series of novel isoreticular, highly porous and stable, aluminum-based metal–organic frameworks with soc topology. From this platform, three compounds were experimentally isolated and fully characterized: namely, the parent Al-soc-MOF-1 and its naphthalene and anthracene analogues. Al-soc-MOF-1 exhibits outstanding gravimetric methane uptake (total and working capacity). It is shown experimentally, for the first tim...

  8. Report of the SocMon capacity development workshop for the Bay of Bengal Large Marine Ecosystem countries in South Asia, St Martin's Island, Bangladesh, 2-11 January, 2015

    OpenAIRE

    Hoon, V.; Saleem, M.; Townsley, P.

    2015-01-01

    Socio-economic Monitoring (SocMon) is an approach and set of tools for conducting socio-economic monitoring of changes in coastal communities. Planned outputs of the workshop included: training of local staff i SocMon methodologies; draft a SocMon report for St. Martin's Island; a workplan for implementing the SocMon; a communication strategy; and key inputs to a regional SocMon strategy

  9. In-situ degradation of pollutants like MTBE, VC and PAh in groundwater using iSOC trademark; In situ Abbau von Schadstoffen wie MTBE, VC und PAK mittels iSOC trademark im Grundwasser

    Energy Technology Data Exchange (ETDEWEB)

    Buhl, J. [Cornelsen Umwelttechnologie GmbH, Essen (Germany)

    2005-07-01

    The iSOC system (in situ Submerged Oxygen Curtain) is a tool for stimulating biological sanitation of groundwater. This is achieved by introducing oxygen into the groundwater, which may be highly efficient in removing pollutants like BTEX, MTBE, VC, and PAH. (orig.)

  10. Progress of study on SOCS1 silent DC vaccine for oncotherapy%SOCS1基因修饰树突状细胞在肿瘤治疗中的研究进展

    Institute of Scientific and Technical Information of China (English)

    远洋; 王雪峰; 李云霞; 穆兰; 潘欣宇

    2011-01-01

    树突状细胞是功能最强的抗原提呈细胞,是启动、调节及维持免疫应答的核心环节,以树突状细胞为基础的肿瘤疫苗被认为是最具潜能的肿瘤免疫治疗手段.细胞因子信号通路抑制因子1(suppressor of cytokine signalingl,SOCS1)是细胞因子信号通路抑制因子(suppressor of cytokine signaling,SOCS)家族的重要成员,广泛参与树突状细胞的发生、成熟和活化,具有负调控树突状细胞功能的重要作用.SOCS1沉默的树突状细胞能够促进自身成熟并增强其诱导的T细胞的抗肿瘤活性.现就国内外关于树突状细胞功能研究及基因修饰的肿瘤疫苗临床试验作一综述,以期对未来的研究有所帮助.%Dendritic cell is the most potent professional antigen-presenting cell, which displays an extraordinary capacity to induce, sustain and regulate immune responses. For this reason, DC vaccine is considered the most potential tumor immune therapy. Suppressor of cytokine signaling 1(SOCS 1) is an important member of SOCS family, which is irreplaceable in the regulation of DC activation, development, and differentiation. SOCS1 represents an inhibitory control mechanism for DC antigen presentation. SOCS1 silent DC could promote DC maturity and enhance the antitumor response of T cell. This paper overviews the current status of dendritic cell function studies and clinical trials on gene-modified DC vaccine, for the purpose of helping the future research.

  11. Effect of the suppressors of cytokine signaling-1(SOCS1) on the differentiation and maturation of bone marrow-derived dendritic cells induced by the TNF superfamily member LIGHT%SOCS1对LIGHT诱导的骨髓来源DC分化成熟的影响

    Institute of Scientific and Technical Information of China (English)

    王琪; 林苹; 张洁; 陆燕蓉; 王修杰; 宁其志; 熊竹娟; 王静

    2005-01-01

    为探讨SOCS1是否参与LIGHT诱导的骨髓来源树突状细胞(BmDC)分化成熟,及其在此过程中的作用.RT-PCR检测受LIGHT刺激后小鼠BmDC、小鼠脾脏来源树突状细胞(sDC)中SOCS1 mRNA水平及BmDC SOCS1 mRNA水平的时间动力学;利用反义核苷酸技术抑制SOCS1的表达,通过流式细胞术(FACS)测定BmDC表面分子CD40、CD86的表达水平来分析阻断SOCS1对LIGHT诱导的BmDC分化成熟的影响.结果显示LIGHT刺激后,BmDC SOCS1 mRNA水平迅速增高,并呈峰度变化,在4 h时达到高峰;正常无SOCS1 mRNA表达的sDC在加LIGHT后可检测到SOCS1 mRNA;所设计SOCS1反义寡核苷酸能特异阻断SOCS1 mRNA;在LIGHT作用下,SOCS1抑制组较非抑制组的CD40表达明显升高(P<0.05),CD86呈中度升高(P<0.05).LIGHT在刺激BmDC分化成熟过程中上调了SOCS1的表达,阻断SOCS1使BmDC对LIGHT的反应更敏感,从而使BmDC成熟度更高;SOCS1对LIGHT诱导的BmDC分化成熟有负反馈调节作用.

  12. Screening for the Interaction Proteins of SOC1 from Phyllostachys violascens Using Yeast Two-Hybrid System%利用酵母双杂交系统筛选雷竹 SOC1相互作用蛋白

    Institute of Scientific and Technical Information of China (English)

    潘现飞; 施泉; 林新春; 徐英武; 曹友志

    2016-01-01

    This work aims to study the target proteins of suppressor of overexpression of constans1(SOC1)in flowering way of Phyllostachys violaceus and to explore the action mechanism of SOC1. The pGBKT7-PvSOC1 vector was constructed as the bait protein,then the cDNA library of P. violascens flowering was established using SMART technology,and the interaction proteins with SOC1 were screened by yeast two-hybrid system as well as analyzed and identified. The results showed that the cDNA library for yeast two-hybrid was constructed successfully,the conversion rate of the library was about 3.0×106 converters per μg pGADT7-Rec,and the capacity of the library was up to 7.5×106 cfu/mL and the insert fragments were distributed from 0.25 kb to 2 kb. The protein interacted with the bait protein PvSOC1 was screened through the yeast two-hybrid technology. The screened target protein was identified as a protein kinase containing plentiful leucine which amino acid sequence was very conservative in different species,and had the highest affinity with rice.%在雷竹(Phyllostachys violascens)中找到 SUPPRESSOR OF OVEREXPRESSION OF CONSTANS1(SOC1)在开花途径中的作用靶标,进一步探索 SOC1的作用机制。构建 pGBKT7-PvSOC1诱饵表达载体,通过 SMART 技术构建开花时期的雷竹 cDNA文库,酵母双杂交筛选与 SOC1互作的蛋白,并对其进行分析鉴定。结果显示,成功构建了可用于酵母双杂交的 cDNA 文库,文库的转化率为每微克 pGADT7-Rec 3.0×106转化子,文库滴度为7.5×106 cfu/mL,插入片段主要在250-2000 bp 之间。通过酵母双杂交实验得到与诱饵蛋白 PvSOC1相互作用的蛋白,筛选到的靶标蛋白经鉴定是一个富含亮氨酸的蛋白激酶,特征氨基酸序列在不同物种中非常保守,与水稻中的同源蛋白亲缘性最高。

  13. SoCRocket: A Virtual Platform for SoC Design

    Science.gov (United States)

    Fossati, Luca; Schuster, Thomas; Meyer, Rolf; Berekovic, Mladen

    2013-08-01

    Both in the commercial and in the aerospace domain, the continuous increase of transistor density on a single die is leading towards the production of more and more complex systems on a single chip, with an increasing number of components. This brought to the introduction of the System-On-Chip (SoC) architecture, that integrates on a single circuit all the elements of a full system. This strive for efficient utilization of the available silicon has triggered several paradigm shifts in system design. Similarly to what happened in the early 1990s, when VHDL and Verilog took over from schematic design, today SystemC and Transaction Level Modeling [1] are about to further raise the design abstraction level. Such descriptions have to be accurate enough to describe the entire system throughout the phases of its development, and has to provide enough flexibility to be refined iteratively up to the point where the actual device can be produced using current process technology. Besides requiring new languages and methodologies, the complexity of current and future SoCs (SCOC3 [16] and NGMP [5] are example in the space domain) forces the SoC design process to rely on pre-designed or third party components. Components obtained from different providers, and even those designed by different teams of the same company, may be heterogeneous on several aspects: design domains, interfaces, abstraction levels, granularity, etc. Therefore, component integration is required at system level. Only by applying design re-use it is possible to successfully and timely design such complex SoCs. This transition to new languages and design methods is also motivated by the implementation with software of an increasing amount of system functionalities. Hence the need for methodologies to enable early software development and which allow the analysis of the performance of the combined Hw/Sw system, as their design and configuration cannot be performed separately. Virtual Prototyping is a key

  14. SOCS3 deficiency in leptin receptor-expressing cells mitigates the development of pregnancy-induced metabolic changes

    Directory of Open Access Journals (Sweden)

    Thais T. Zampieri

    2015-03-01

    Conclusions: Our study identified the increased hypothalamic expression of SOCS3 as a key mechanism responsible for triggering pregnancy-induced leptin resistance and metabolic adaptations. These findings not only help to explain a common phenomenon of the mammalian physiology, but it may also aid in the development of approaches to prevent and treat gestational metabolic imbalances.

  15. DMPD: Regulation of innate immunity by suppressor of cytokine signaling (SOCS)proteins. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available oteins. Dalpke A, Heeg K, Bartz H, Baetz A. Immunobiology. 2008;213(3-4):225-35. Epub 2007 Nov 28. (.png) (....ignaling (SOCS)proteins. Authors Dalpke A, Heeg K, Bartz H, Baetz A. Publication Immunobiology. 2008;213(3-4

  16. Fasciola hepatica tegumental coat antigen suppresses MAPK signalling in dendritic cells and up-regulates the expression of SOCS3.

    Science.gov (United States)

    Vukman, K V; Adams, P N; O'Neill, S M

    2013-07-01

    Fasciola hepatica tegumental coat antigen (FhTeg) suppresses dendritic cell maturation and function by inhibiting IL-6, tumour necrosis factor (TNF)-α, IL-10 and IL-12 production and CD80, CD86 and CD40 cell surface marker expression in TLR4-stimulated dendritic cells. Fasciola hepatica also impairs dendritic cell function by inhibiting its phagocytic capacity and its ability to prime T cells. We have shown previously that activation of mast cells with bacterial ligands is also inhibited by FhTeg. Fasciola hepatica suppresses LPS-induced NF-κB and MAPK pathway (ERK) activation in these cells. Previously, we demonstrated that FhTeg induces expression of suppressor of cytokine signalling (SOCS)3, a negative regulator of the TLR pathway in mast cells. In this study, we show the same inhibitory effect of FhTeg on the activation of the other members of the MAPKs pathway (ERK, p38, JNK) in dendritic cells and demonstrate an enhanced expression of SOCS3, but not SOCS1, SOCS5 or PIAS3 in this process. These studies enhance our understanding of the immunomodulatory effect of helminth molecules on the TLR pathway.

  17. Mixed micellar properties of sodium n-octanoate(SOC) with n-octylammonium chloride(OAC) in aqueous solution

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Byung Hwan [Korea University of Technology, Chonan (Korea, Republic of)

    2002-12-01

    The critical concentration(CMC) and the counterion binding constant(B) for the mixed micellization of sodium n-octanoate(SOC) with n-octylammonium chloride(OAC) were determined as a function of the overall mole fraction of SOC({alpha}{sub 1}). Various thermodynamic parameters(X{sub i}, {gamma}{sub i}, C{sub i}, a{sub i}{sup M}, and {delta}H{sub mix}) for the mixed micellization of the SOC/OAC systems have been calculated and analyzed by means of the equations derived from the nonideal mixed micellar model. The results show that there are great deviations from the ideal behavior for the mixed micellization of these systems. And other thermodynamic parameters({delta}G{sub m}{sup o}, {delta}H{sub m}{sup o}, and {delta}S{sub m}{sup o}) associated with the micellization of SOC, OAC, and their mixture({alpha}{sub 1}=0.5) have been also estimated from the temperature dependence of CMC and B values, and the significance of these parameters and their relation to the theory of the micelle formation have been considered and analyzed by comparing each other.

  18. The Social Orienting Continuum and Response Scale (SOC-RS): A Dimensional Measure for Preschool-Aged Children

    Science.gov (United States)

    Mosconi, Matthew W.; Reznick, J. Steven; Mesibov, Gary; Piven, Joseph

    2009-01-01

    Children with autism show deficits in social referencing, joint attention, orienting to their names, and social smiling as early as the first year of life. The present study describes the development of the Social Orienting Continuum and Response Scale (SOC-RS), a quantitative scale assessing each of these behaviors during the course of…

  19. SOC-DS computer code provides tool for design evaluation of homogeneous two-material nuclear shield

    Science.gov (United States)

    Disney, R. K.; Ricks, L. O.

    1967-01-01

    SOC-DS Code /Shield Optimization Code-Direc Search/, selects a nuclear shield material of optimum volume, weight, or cost to meet the requirments of a given radiation dose rate or energy transmission constraint. It is applicable to evaluating neutron and gamma ray shields for all nuclear reactors.

  20. Comparison Study on Two Model-Based Adaptive Algorithms for SOC Estimation of Lithium-Ion Batteries in Electric Vehicles

    Directory of Open Access Journals (Sweden)

    Yong Tian

    2014-12-01

    Full Text Available State of charge (SOC estimation is essential to battery management systems in electric vehicles (EVs to ensure the safe operations of batteries and providing drivers with the remaining range of the EVs. A number of estimation algorithms have been developed to get an accurate SOC value because the SOC cannot be directly measured with sensors and is closely related to various factors, such as ambient temperature, current rate and battery aging. In this paper, two model-based adaptive algorithms, including the adaptive unscented Kalman filter (AUKF and adaptive slide mode observer (ASMO are applied and compared in terms of convergence behavior, tracking accuracy, computational cost and estimation robustness against parameter uncertainties of the battery model in SOC estimation. Two typical driving cycles, including the Dynamic Stress Test (DST and New European Driving Cycle (NEDC are applied to evaluate the performance of the two algorithms. Comparison results show that the AUKF has merits in convergence ability and tracking accuracy with an accurate battery model, while the ASMO has lower computational cost and better estimation robustness against parameter uncertainties of the battery model.

  1. A Control Method for Balancing the SoC of Distributed Batteries in Islanded Converter-Interfaced Microgrids

    Directory of Open Access Journals (Sweden)

    Spyros I. Gkavanoudis

    2016-01-01

    Full Text Available In a low-voltage islanded microgrid powered by renewable energy sources, the energy storage systems (ESSs are considered necessary, in order to maintain the power balance. Since a microgrid can be composed of several distributed ESSs (DESSs, a coordinated control of their state-of-charge (SoC should be implemented, ensuring the prolonged lifespan. This paper proposes a new decentralized control method for balancing the SoC of DESSs in islanded microgrids, without physical communication. Each DESS injects a current distortion at 175 Hz, when its SoC changes by 10%. This distortion is recognized by every DESS, through a phase-locked loop (PLL. In order to distinguish the origin of the distortion, each DESS injects a distortion of different time duration. This intermediate frequency has been selected in order to avoid the concurrence with the usual harmonics. The DESSs take advantage of this information and inject a current proportional to the SoC. Implementing this strategy, a comparable number of charging/discharging cycles for each DESS are achieved. Furthermore, an active filter operation, implemented in the dq rotating frame for each individual harmonic, is integrated in the control of the distributed generation units, supplying nonlinear loads with high-quality voltage. The effectiveness of this method is verified by detailed simulation results.

  2. Macrophage Deletion of SOCS1 Increases Sensitivity to LPS and Palmitic Acid and Results in Systemic Inflammation and Hepatic Insulin Resistance

    Science.gov (United States)

    Graham, Kate L.; Galic, Sandra; Honeyman, Jane E.; Fynch, Stacey L.; Hewitt, Kimberly A.; Kay, Thomas W.

    2011-01-01

    OBJECTIVE Macrophage secretion of proinflammatory cytokines contributes to the pathogenesis of obesity-related insulin resistance. An important regulator of inflammation is the suppressor of cytokine signaling-1 (SOCS1), which inhibits the JAK-STAT and toll-like receptor-4 (TLR4) pathways. Despite the reported role of SOCS1 in inhibiting insulin signaling, it is surprising that a SOCS1 polymorphism that increases SOCS1 promoter activity is associated with enhanced insulin sensitivity despite obesity. In the current study, we investigated the physiological role of myeloid and lymphoid cell SOCS1 in regulating inflammation and insulin sensitivity. RESEARCH DESIGN AND METHODS We used mice generated by crossing SOCS1 floxed mice with mice expressing Cre recombinase under the control of the LysM-Cre promoter (SOCS1 LysM-Cre). These mice have deletion of SOCS1 in macrophages and lymphocytes. We assessed macrophage inflammation using flow cytometry and serum cytokine levels using Bioplex assays. We then measured insulin sensitivity using glucose tolerance tests and the euglycemic-hyperinsulinemic clamp. Using bone marrow–derived macrophages, we tested the effects of SOCS1 deletion in regulating responses to the TLR4 ligands: lipopolysaccharide (LPS) and palmitic acid. RESULTS SOCS1 LysM-Cre mice had increased macrophage expression of CD11c, enhanced sensitivity to LPS, and palmitic acid and increased serum concentrations of tumor necrosis factor-α, interleukin-6, and monocyte chemoattractant protein. Increased inflammation was associated with impaired glucose tolerance and hyperinsulinemia as a result of reduced hepatic but not skeletal muscle insulin sensitivity. CONCLUSIONS The expression of SOCS1 in hematopoietic cells protects mice against systemic inflammation and hepatic insulin resistance potentially by inhibiting LPS and palmitate-induced TLR4 signaling in macrophages. PMID:21646388

  3. Plant growth controls short-term changes in soil organic carbon (SOC) stocks of croplands - new insights from the CarboZALF experiment

    Science.gov (United States)

    Hoffmann, Mathias; Jurisch, Nicole; Garcia Alba, Joana; Albiac Borraz, Elisa; Schmidt, Marten; Verch, Gernot; Sommer, Michael; Augustin, Jürgen

    2016-04-01

    The long-term influence of crop rotations, climate conditions or soil type on soil organic carbon stock (SOC) patterns and gaseous C emissions of agricultural landscapes is widely recognized. However, the question of short-term seasonal changes in SOC within these areas remains unclear. A main reason for this is the detection problem of temporal and spatial variability in gaseous C exchange and thus, changes in SOC stocks (ΔSOC) in a high resolution. This study introduces dynamic C balances as a method to obtain seasonal changes in SOC stocks. Dynamic C balances were calculated by a combination of automatic chamber CO2 exchange measurements and empirical biomass models. Measurements were performed for three consecutive years at a colluvial depression (Colluvic Regosol) in the hummocky ground moraine landscape of NE Germany (CarboZALF experimental site). The investigated crop rotation was maize, winter fodder rye, maize, winter fodder rye, and sudangrass. The site is characterized by a gradient in ground water level (GWL) and related spatial heterogeneity in soil properties, such as SOC as well as soil nitrogen (Nt) stocks. Modelled dynamic C balances reveal that up to 79% of the standard deviation of estimated annual ΔSOC between single chambers emerged during the main period of crop growth (three months in summer). No significant changes in ΔSOC were detected outside the growing season. Instead, differences between chambers remain constant despite ΔSOC dynamics. Environmental variables (Nt stocks of Ap horizon and GWL), affecting plant-mediated C sequestration, explained up to 95% of temporal and spatial variability in CO2 exchange and ΔSOC. Thus, plant activities were the major catalyst for small scale differences in annual ΔSOC of croplands.

  4. Gaining Insights on the H2–Sorbent Interactions: Robust soc-MOF Platform as a Case Study

    KAUST Repository

    Cairns, Amy J.

    2016-09-18

    We report on the synthesis and gas adsorption properties (i.e., Ar and H2) of four robust 3-periodic metal–organic frameworks (MOFs) having the targeted soc topology. These cationic MOFs are isostructural to the parent indium-based MOF, In-soc-MOF-1a (for NO3–), previously reported by us, and likewise are constructed from the assembly of rigid μ3-oxygen-centered trinuclear metal carboxylate clusters, [M3O(O2C−)6], where M = In3+ or Fe3+. Each inorganic trinuclear molecular building block (MBB), generated in situ, is bridged by six 3,3′,5,5′-azobenzenetetracarboxylate (ABTC4–) ligands to give the extended (4,6)-connected MOF, soc-MOF. In our previous work, we confirmed that the parent soc-MOF, i.e., In-soc-MOF-1a, possesses unique structural characteristics (e.g., vacant In binding sites and narrow pores with higher localized charge density), which led to exceptional hydrogen (H2) storage capabilities. Therefore, charged MOFs with soc topology can be viewed collectively as an ideal prototypical platform to examine the impact of specific structural parameters on H2–MOF interactions via systematic gas adsorption studies. We infer that enhanced binding of molecular H2 is primarily governed by the presence and type of vacant metal centers (i.e., Fe was shown to exhibit stronger H2–MOF interactions at low H2 loading compared to the In analogues). These findings are evident from the associated isosteric heat of adsorption (Qst) at low loadings and inelastic neutron scattering (INS) experiments of the rotational transitions of sorbed H2, as well as, temperature-programmed desorption (TPD) studies (for a select compound). The importance of localized charge density is also highlighted, where the extra-framework nitrate anions in the Fe-soc-MOF-1a (for NO3–) facilitate enhanced binding affinities as compared to the chloride analogue.

  5. An On-Chip Bus Tracer Analyzer With Amba AHB For Real Time Tracing With Lossless Data Compression For SOC

    Directory of Open Access Journals (Sweden)

    KOKA SRIKANTH

    2014-09-01

    Full Text Available The Advanced Microcontroller Bus Architecture (AMBA widely used as the on-chip bus in System-on-a-chip (SoC designs. The important aspect of a SoC is not only which components or blocks it houses, but also how they are interconnected. AMBA is a solution for the blocks to interface with each other. The biggest challenge in SoC design is in validating and testing the system. AHB Bus Tracer is a significant infrastructure that is needed to monitor the on chip-bus signals, which is vital for debugging and performance analysis and also optimizing the SOC. Basically on chip signals are difficult to observe since they are deeply embedded in a SoC and no sufficient I/O pins are required to access those signals. Therefore, we embed a bus tracer in SoC to capture the bus signals and store them. The AMBA AHB should be used to which are high bandwidth and require the high performance of a pipelined bus interface. Performance can be improved at high-frequency operation. Performance is independent of the mark-space ratio of the clock. No special considerations are required for automatic test insertion. Our aim in this project is to Design the AHB- protocol with bus tracer. For real-time tracing, we should reduce the trace size as much as possible without reducing the original data.SYS-HMRBT supports tracing after/before an event triggering, named post-triggering trace/pre-triggering trace, respectively. SYS-HMRBT runs at 500 MHz and costs 42 K gates in TSMC 0.13- m technology, indicating that it is capable of real time tracing and is very small in modern SoCs.The experimental results show that trace compression ratio reduced by 96.32%. Finally this approach was designed successfully along with MODEL SIM and synthesis using Xilinx ISE. The SoC can be verified in field-programmable gate array.

  6. Prediction of SOC content by Vis-NIR spectroscopy at European scale using a modified local PLS algorithm

    Science.gov (United States)

    Nocita, M.; Stevens, A.; Toth, G.; van Wesemael, B.; Montanarella, L.

    2012-12-01

    In the context of global environmental change, the estimation of carbon fluxes between soils and the atmosphere has been the object of a growing number of studies. This has been motivated notably by the possibility to sequester CO2 into soils by increasing the soil organic carbon (SOC) stocks and by the role of SOC in maintaining soil quality. Spatial variability of SOC masks its slow accumulation or depletion, and the sampling density required to detect a change in SOC content is often very high and thus very expensive and labour intensive. Visible near infrared diffuse reflectance spectroscopy (Vis-NIR DRS) has been shown to be a fast, cheap and efficient tool for the prediction of SOC at fine scales. However, when applied to regional or country scales, Vis-NIR DRS did not provide sufficient accuracy as an alternative to standard laboratory soil analysis for SOC monitoring. Under the framework of Land Use/Cover Area Frame Statistical Survey (LUCAS) project of the European Commission's Joint Research Centre (JRC), about 20,000 samples were collected all over European Union. Soil samples were analyzed for several physical and chemical parameters, and scanned with a Vis-NIR spectrometer in the same laboratory. The scope of our research was to predict SOC content at European scale using LUCAS spectral library. We implemented a modified local partial least square regression (l-PLS) including, in addition to spectral distance, other potentially useful covariates (geography, texture, etc.) to select for each unknown sample a group of predicting neighbours. The dataset was split in mineral soils under cropland, mineral soils under grassland, mineral soils under woodland, and organic soils due to the extremely diverse spectral response of the four classes. Four every class training (70%) and test (30%) sets were created to calibrate and validate the SOC prediction models. The results showed very good prediction ability for mineral soils under cropland and mineral soils

  7. Tolerogenic nanoparticles inhibit T cell-mediated autoimmunity through SOCS2.

    Science.gov (United States)

    Yeste, Ada; Takenaka, Maisa C; Mascanfroni, Ivan D; Nadeau, Meghan; Kenison, Jessica E; Patel, Bonny; Tukpah, Ann-Marcia; Babon, Jenny Aurielle B; DeNicola, Megan; Kent, Sally C; Pozo, David; Quintana, Francisco J

    2016-06-21

    Type 1 diabetes (T1D) is a T cell-dependent autoimmune disease that is characterized by the destruction of insulin-producing β cells in the pancreas. The administration to patients of ex vivo-differentiated FoxP3(+) regulatory T (Treg) cells or tolerogenic dendritic cells (DCs) that promote Treg cell differentiation is considered a potential therapy for T1D; however, cell-based therapies cannot be easily translated into clinical practice. We engineered nanoparticles (NPs) to deliver both a tolerogenic molecule, the aryl hydrocarbon receptor (AhR) ligand 2-(1'H-indole-3'-carbonyl)-thiazole-4-carboxylic acid methyl ester (ITE), and the β cell antigen proinsulin (NPITE+Ins) to induce a tolerogenic phenotype in DCs and promote Treg cell generation in vivo. NPITE+Ins administration to 8-week-old nonobese diabetic mice suppressed autoimmune diabetes. NPITE+Ins induced a tolerogenic phenotype in DCs, which was characterized by a decreased ability to activate inflammatory effector T cells and was concomitant with the increased differentiation of FoxP3(+) Treg cells. The induction of a tolerogenic phenotype in DCs by NPs was mediated by the AhR-dependent induction of Socs2, which resulted in inhibition of nuclear factor κB activation and proinflammatory cytokine production (properties of tolerogenic DCs). Together, these data suggest that NPs constitute a potential tool to reestablish tolerance in T1D and potentially other autoimmune disorders.

  8. Design of adaptive deblocking filter for H.264/AVC decoder SOC

    Institute of Scientific and Technical Information of China (English)

    YANG Kun; ZHANG Chun; WANG Zhi-hua

    2009-01-01

    In this article, a design for the adaptive deblocking filter is proposed. To understand the real-time performance, a FILTER unit that can process eight pixels beside an edge simultaneously is applied in this design to increase filtering efficiency, and local memory is used to store all temporary data generated by the FILTER to reduce access to system bus. The filter makes every 4×4 sample block pipelined through the process units and achieves an efficiency of 80% for both the FILTER unit and the bus access unit. It can fulfill filtering process for a crystallographic information file (CIF, 352×288) format picture in 95 k clock cycles. The proposed design is part of a H.264/AVC decoder system-on-chip (SOC), which is fabricated in 0.18 μm complementary metal oxide semiconductor (CMOS) process. The filter module consists of 60 k gates and 25.7 kb static random access memory (SRAM) and it can filter a macro-block in 240 clock cycles.

  9. Co-verification of hardware and software for ARM SoC design

    CERN Document Server

    Andrews, Jason

    2004-01-01

    Hardware/software co-verification is how to make sure that embedded system software works correctly with the hardware, and that the hardware has been properly designed to run the software successfully -before large sums are spent on prototypes or manufacturing. This is the first book to apply this verification technique to the rapidly growing field of embedded systems-on-a-chip(SoC). As traditional embedded system design evolves into single-chip design, embedded engineers must be armed with the necessary information to make educated decisions about which tools and methodology to deploy. SoC verification requires a mix of expertise from the disciplines of microprocessor and computer architecture, logic design and simulation, and C and Assembly language embedded software. Until now, the relevant information on how it all fits together has not been available. Andrews, a recognized expert, provides in-depth information about how co-verification really works, how to be successful using it, and pitfalls to avoid. H...

  10. Ahb Compatible DDR Sdram Controller Ip Core for Arm Based Soc

    CERN Document Server

    Shashikumar, Dr R; Nagendrakumar, M; Hemanthkumar, C S

    2010-01-01

    DDR SDRAM is similar in function to the regular SDRAM but doubles the bandwidth of the memory by transferring data on both edges of the clock cycles. DDR SDRAM most commonly used in various embedded application like networking, image or video processing, Laptops ete. Now a days many applications needs more and more cheap and fast memory. Especially in the field of signal processing, requires significant amount of memory. The most used type of dynamic memory for that purpose is DDR SDRAM. For FPGA design the IC manufacturers are providing commercial memory controller IP cores working only on their products. Main disadvantage is the lack of memory access optimization for random memory access patterns. The data path part of those controllers can be used free of charge. This work propose an architecture of a DDR SDRAM controller, which takes advantage of those available and well tested data paths and can be used for any FPGA device or ASIC design.(5). In most of the SOC design, DDR SDRAM is commonly used. ARM pro...

  11. Development of a strontium optical lattice clock for the SOC mission on the ISS

    CERN Document Server

    Bongs, K; Smith, L; He, W; Kock, O; Swierad, D; Hughes, J; Schiller, S; Alighanbari, S; Origlia, S; Vogt, S; Sterr, U; Lisdat, Ch; Targat, R Le; Lodewyck, J; Holleville, D; Venon, B; Bize, S; Barwood, G P; Gill, P; Hill, I R; Ovchinnikov, Y B; Poli, N; Tino, G M; Stuhler, J; Kaenders, W

    2015-01-01

    Ultra-precise optical clocks in space will allow new studies in fundamental physics and astronomy. Within an European Space Agency (ESA) program, the Space Optical Clocks (SOC) project aims to install and to operate an optical lattice clock on the International Space Station (ISS) towards the end of this decade. It would be a natural follow-on to the ACES mission, improving its performance by at least one order of magnitude. The payload is planned to include an optical lattice clock, as well as a frequency comb, a microwave link, and an optical link for comparisons of the ISS clock with ground clocks located in several countries and continents. Within the EU-FP7-SPACE-2010-1 project no. 263500, during the years 2011-2015 a compact, modular and robust strontium lattice optical clock demonstrator has been developed. Goal performance is a fractional frequency instability below 1x10^{-15}, tau^{-1/2} and a fractional inaccuracy below 5x10^{-17}. Here we describe the current status of the apparatus' development, i...

  12. Implementation of SoC Based Real-Time Electromagnetic Transient Simulator

    Directory of Open Access Journals (Sweden)

    I. Herrera-Leandro

    2017-01-01

    Full Text Available Real-time electromagnetic transient simulators are important tools in the design stage of new control and protection systems for power systems. Real-time simulators are used to test and stress new devices under similar conditions that the device will deal with in a real network with the purpose of finding errors and bugs in the design. The computation of an electromagnetic transient is complex and computationally demanding, due to features such as the speed of the phenomenon, the size of the network, and the presence of time variant and nonlinear elements in the network. In this work, the development of a SoC based real-time and also offline electromagnetic transient simulator is presented. In the design, the required performance is met from two sides, (a using a technique to split the power system into smaller subsystems, which allows parallelizing the algorithm, and (b with specialized and parallel hardware designed to boost the solution flow. The results of this work have shown that for the proposed case studies, based on a balanced distribution of the node of subsystems, the proposed approach has decreased the total simulation time by up to 99 times compared with the classical approach running on a single high performance 32-bit embedded processor ARM-Cortex A9.

  13. Gene therapy with neurogenin3, betacellulin and SOCS1 reverses diabetes in NOD mice.

    Science.gov (United States)

    Li, R; Buras, E; Lee, J; Liu, R; Liu, V; Espiritu, C; Ozer, K; Thompson, B; Nally, L; Yuan, G; Oka, K; Chang, B; Samson, S; Yechoor, V; Chan, L

    2015-11-01

    Islet transplantation for type 1 diabetes is limited by a shortage of donor islets and requirement for immunosuppression. We approached this problem by inducing in vivo islet neogenesis in non-obese diabetic (NOD) diabetic mice, a model of autoimmune diabetes. We demonstrate that gene therapy with helper-dependent adenovirus carrying neurogenin3 (Ngn3), an islet lineage-defining transcription factor, and betacellulin (Btc), an islet growth factor, leads to the induction of periportal insulin-positive cell clusters in the liver, which are rapidly destroyed. To specifically accord protection to these 'neo-islets' from cytokine-mediated destruction, we overexpressed suppressor of cytokine signaling 1 (SOCS1) gene, using a rat insulin promoter in combination with Ngn3 and Btc. With this approach, about half of diabetic mice attained euglycemia sustained for over 4 months, regain glucose tolerance and appropriate glucose-stimulated insulin secretion. Histological analysis revealed periportal islet hormone-expressing 'neo-islets' in treated mouse livers. Despite evidence of persistent 'insulitis' with activated T cells, these 'neo-islets' persist to maintain euglycemia. This therapy does not affect diabetogenicity of splenocytes, as they retain the ability to transfer diabetes. This study thus provides a proof-of-concept for engineering in vivo islet neogenesis with targeted resistance to cytokine-mediated destruction to provide a long-term reversal of diabetes in NOD mice.

  14. Normally Off ECG SoC With Non-Volatile MCU and Noise Tolerant Heartbeat Detector.

    Science.gov (United States)

    Izumi, Shintaro; Yamashita, Ken; Nakano, Masanao; Yoshimoto, Shusuke; Nakagawa, Tomoki; Nakai, Yozaburo; Kawaguchi, Hiroshi; Kimura, Hiromitsu; Marumoto, Kyoji; Fuchikami, Takaaki; Fujimori, Yoshikazu; Nakajima, Hiroshi; Shiga, Toshikazu; Yoshimoto, Masahiko

    2015-10-01

    This paper describes an electrocardiograph (ECG) monitoring SoC using a non-volatile MCU (NVMCU) and a noise-tolerant instantaneous heartbeat detector. The novelty of this work is the combination of the non-volatile MCU for normally off computing and a noise-tolerant-QRS (heartbeat) detector to achieve both low-power and noise tolerance. To minimize the stand-by current of MCU, a non-volatile flip-flop and a 6T-4C NVRAM are used. Proposed plate-line charge-share and bit-line non-precharge techniques also contribute to mitigate the active power overhead of 6T-4C NVRAM. The proposed accurate heartbeat detector uses coarse-fine autocorrelation and a template matching technique. Accurate heartbeat detection also contributes system-level power reduction because the active ratio of ADC and digital block can be reduced using heartbeat prediction. Measurement results show that the fully integrated ECG-SoC consumes 6.14 μ A including 1.28- μA non-volatile MCU and 0.7- μA heartbeat detector.

  15. Technology-design-manufacturing co-optimization for advanced mobile SoCs

    Science.gov (United States)

    Yang, Da; Gan, Chock; Chidambaram, P. R.; Nallapadi, Giri; Zhu, John; Song, S. C.; Xu, Jeff; Yeap, Geoffrey

    2014-03-01

    How to maintain the Moore's Law scaling beyond the 193 immersion resolution limit is the key question semiconductor industry needs to answer in the near future. Process complexity will undoubtfully increase for 14nm node and beyond, which brings both challenges and opportunities for technology development. A vertically integrated design-technologymanufacturing co-optimization flow is desired to better address the complicated issues new process changes bring. In recent years smart mobile wireless devices have been the fastest growing consumer electronics market. Advanced mobile devices such as smartphones are complex systems with the overriding objective of providing the best userexperience value by harnessing all the technology innovations. Most critical system drivers are better system performance/power efficiency, cost effectiveness, and smaller form factors, which, in turns, drive the need of system design and solution with More-than-Moore innovations. Mobile system-on-chips (SoCs) has become the leading driver for semiconductor technology definition and manufacturing. Here we highlight how the co-optimization strategy influenced architecture, device/circuit, process technology and package, in the face of growing process cost/complexity and variability as well as design rule restrictions.

  16. Real-time Face Detection and Tracking Using Haar Classifier on SoC

    Directory of Open Access Journals (Sweden)

    Rajashree Tripathy

    2014-03-01

    Full Text Available In this paper we intend to Implement a real time Face detection and tracking the head poses position from high definition video using Haar Classifier through Raspberry Pi BCM2835 CPU processor which is a combination of SoC with GPU based Architecture. OV5647 CMOS Image sensor with 5-megapixel used for obtaining high definition video H.264 video data via GPU’s hardware video decoder to improve the playback of H.264 Video data supporting from 1080p at 30fps with complete user control over formatting and output data transfer also supporting with 720p/60HD video in full field of View(FOV. SimpleCV and OpenCV libraries are used for face detection and tracking the head poses position. The experimental result computed by using computer vision SimpleCV and OpenCV framework libraries along with above mentioned hardware results were obtained through of 30 fps under 1080p resolutions for higher accuracy and speediness for face detection and tracking the head poses position.

  17. Role of the suppressor of cytokine signaling 2 (SOCS2) during meningoencephalitis caused by Bovine herpesvirus 5 (BoHV-5).

    Science.gov (United States)

    Aparecida Silva Barbosa, Aline; Freitas Versiani, Alice; Fonseca da Cunha Sousa, Larissa; Silva de Miranda, Aline; Gasparini, Marcela Ribeiro; Brant, Fátima; Silva, Daniele Gonçalves; Luisa Quintino-de-Carvalho, Iracema; Marianetti Soriani, Frederico; Guimarães da Fonseca, Flávio; César Vasconcelos, Anilton; da Silva Barcelos, Lucíola; Martins Teixeira, Mauro; Lúcio Teixeira, Antônio; Machado, Fabiana Simão; Barbosa-Stancioli, Edel Figueiredo; Rachid, Milene Alvarenga

    2016-08-01

    The role of suppressors of cytokine signaling (SOCS) in meningoencephalitis caused by Bovine herpesvirus 5 (BoHV-5) was evaluated by intracranial infection in C57BL/6 wild-type mice (WT) and SOCS2 deficient mice (SOCS2(-/-)). Both infected groups presented weight loss, ruffled fur and hunched posture. Additionally, infected SOCS2(-/-) mice showed swollen chamfer and progressive depression. Infected WT animals developed mild meningitis, characterized by infiltration of mononuclear cells. Moreover, viral DNA was detected in liver and lung from infected WT group. This group also showed elevated brain levels of IFN-γ, IL-10, CXCL1 and CCL5, when compared with non-infected WT animals. Brain inflammation was exacerbated in infected SOCS2(-/-) mice with widespread distribution of the virus and increased brain levels of TNF-α, IFN-γ, IL-10, IL-12, CXCL1 and CCL5, when compared with WT infected mice. Moreover, infected SOCS2 deficient mice exhibited reduced brain mRNA expression of IFNα and IFNβ and increased expression of mRNA of SOCS1, compared with infected WT mice. Taken together, our study provides an insight into the role of SOCS2 in modulating the immune response to BoHV-5 infection. Copyright © 2016 Elsevier Ltd. All rights reserved.

  18. Different Transcription Profiles of SOCS-3, ob and IGF-Ⅰ Genes and their Possible Correlations in Obese and Lean Pigs

    Institute of Scientific and Technical Information of China (English)

    Jiangwei WU; Bo WANG; Haowei ZHANG; Taiyong YU; Gongshe YANG

    2007-01-01

    Pig breeds have significant differences in fat deposition and muscle development ability.However, the molecular mechanism behind these differences is still unknown. In this study, the expression patterns of three candidate genes, suppressor of cytokine signaling 3 (SOCS-3), obesity (ob) and insulin-like growth factor Ⅰ (IGF-Ⅰ), which are involved in adipose metabolism or muscle development, were analyzed.Total RNA was extracted from dorsal subcutaneous adipose tissue and longissi(m)us of 8-month-old Bamei and Largewhite pigs. Semiquantitative reverse transcription-polymerase chain reaction was used to determine the expression levels of the SOCS-3 and ob genes in adipose tissue, and SOCS-3 and IGF-Ⅰ genes in muscletissue. The results showed that in adipose tissue the expression level of SOCS-3 was significantly higher in Bamei (obese) pigs than that in Largewhite (lean) pigs (P<0.01). However, in muscle tissue it was significantly lower in Bamei than that in Largewhite pigs (P<0.01). Furthermore, the expression of SOCS-3 was positively correlated to that of ob in adipose tissue and that of IGF-Ⅰ in muscletissue. These findings suggest that the difference in SOCS-3 gene expression levels in adipose and muscle tissues, the relationship between SOCS-3 and ob in adipose tissue, and that between SOCS-3 and IGF-Ⅰ in muscle tissue, might contribute to the different fat deposition and muscle development ability between obese and lean pigs.

  19. Sense of coherence and substance use in Spanish adolescents. Does the effect of SOC depend on patterns of substance use in their peer group?

    Science.gov (United States)

    García-Moya, Irene; Jiménez-Iglesias, Antonia; Moreno, Carmen

    2013-01-01

    The aims of this work were to analyse the relationships between sense of coherence (SOC) and substance use among Spanish adolescents and to examine the potential moderator effect of the patterns of substance use in the peer group. Sample consisted of 5475 Spanish adolescents aged 15 to 18 from the 2010 edition of the Health Behaviour in School-aged Children (HBSC) study. Statistical analysis included cluster analysis to identify groups of adolescents according to their peer group's patterns of substance use and logistic regression with SOC and peers' pattern of consumption as predictors of current tobacco use, current alcohol use, life-time drunkenness and current drunkenness. The results showed that a strong SOC seemed to reduce the adolescents' likelihood of involving in tobacco use and drunkenness, but it was not associated with being a current drinker. In addition, the protective effect of SOC was moderated by peers' patterns of substance use. Specifically, SOC had a significant protective influence in adolescents whose peer group showed either a nonconsumption pattern or a pattern of frequent alcohol use and occasional drunkenness; but the protective effect of SOC disappeared if peers showed a pattern of consumption that included illegal drugs. In conclusion, SOC tends to act as a protective personal variable with respect to substance use during adolescence, but the influence exerted by the peer group seems to moderate the aforementioned protective effect of SOC.

  20. Comments on "Precise model measurements versus theoretical prediction of barrier insertion loss in presence of the ground" [J. Acoust. Soc. Am. 73, 44–54 (1983)

    DEFF Research Database (Denmark)

    Rasmussen, Karsten Bo

    1983-01-01

    Some of the theoretical curves in the article by J. Nicolas et al. [J. Acoust. soc. Am. 73, 44–54 (1983)] appear to be erroneous.......Some of the theoretical curves in the article by J. Nicolas et al. [J. Acoust. soc. Am. 73, 44–54 (1983)] appear to be erroneous....

  1. Long-term N fertilization and conservation tillage practices conserve surface but not profile SOC stocks under semi-arid irrigated corn

    Science.gov (United States)

    No tillage (NT) and N fertilization can increase surface soil organic C (SOC) stocks, but the effects deeper in the soil profile are uncertain. Subsequent tillage could counter SOC stabilized through NT practices by disrupting soil aggregation and promoting decomposition. We followed a long-term ti...

  2. Progress in study on relationship between SOCS3 and early pregnancy outcome%SOCS3与早期妊娠结局的关系研究进展

    Institute of Scientific and Technical Information of China (English)

    孙艳兰; 程玲慧; 曹云霞

    2011-01-01

    Cytokine signal transduction negative regulatory factor 3 ( SOCS3 ) is a member of the SOCS family and is a group of protein molecules with negative feedback regulation for the cytokine signaling pathways, and they can be induced by a variety of cytokines, mainly involving in cytokine signaling transduction in negative regulation for leukemia inhibitory factor( LIF), interleukin (IL), tumor necrosis factor(TNF), erythropoietin(EPO) and other cytokines. SOCS3 can regulate Thl/Th2 cytokines balance, while maintenance of normal pregnancy is associated with regulation of T cells. So it is considered that abnormal expression of SOCS3 protein may be associated with abnormal immune tolerance in maternal-fetal interface and occurrence of spontaneous abortion. This article reviewed influences of SOCS3 on early pregnancy outcome.%细胞因子信号转导负调控因子(SOCS)3是细胞因子信号转导负调控因子家族中的一员,是对细胞因子信号通路具有负反馈调节作用的蛋白分子,且可被多种细胞因子诱导产生,主要参与负调控白细胞抑制因子、白细胞介素、肿瘤坏死因子、红细胞生成素等细胞因子的信号转导.细胞因子信号转导负调控因子3可调控Th1/Th2型细胞因子平衡,正常妊娠的维持与T细胞调节有关,因此,可以认为细胞因子信号转导负调控因子3蛋白的表达异常可能与母胎界面免疫耐受异常及自然流产的发生有关.该文就细胞因子信号转导负调控因子3对早期妊娠结局的影响作用进行综述.

  3. Molecular Cloning, Characterization, and Expression of MiSOC1: A Homolog of the Flowering Gene SUPPRESSOR OF OVEREXPRESSION OF CONSTANS1 from Mango (Mangifera indica L).

    Science.gov (United States)

    Wei, Junya; Liu, Debing; Liu, Guoyin; Tang, Jie; Chen, Yeyuan

    2016-01-01

    MADS-box transcription factor plays a crucial role in plant development, especially controlling the formation and development of floral organs. Mango (Mangifera indica L) is an economically important fruit crop, but its molecular control of flowering is largely unknown. To better understand the molecular basis of flowering regulation in mango, we isolated and characterized the MiSOC1, a putative mango orthologs for the Arabidopsis SUPPRESSOR OF OVEREXPRESSION OF CONSTANS1/AGAMOUS-LIKE 20 (SOC1/AGL20) with homology-based cloning and RACE. The full-length cDNA (GenBank accession No.: KP404094) is 945 bp in length including a 74 bp long 5' UTR and a 189 bp long 3' UTR and the open reading frame was 733 bps, encoding 223 amino acids with molecular weight 25.6 kD. Both sequence alignment and phylogenetic analysis all indicated that deduced protein contained a conservative MADS-box and semi-conservative K domain and belonged to the SOC1/TM3 subfamily of the MADS-box family. Quantitative real-time PCR was performed to investigate the expression profiles of MiSOC1 gene in different tissues/organs including root, stem, leaves, flower bud, and flower. The result indicated MiSOC1 was widely expressed at different levels in both vegetative and reproductive tissues/organs with the highest expression level in the stems' leaves and inflorescences, low expression in roots and flowers. The expression of MiSOC1 in different flower developmental stages was different while same tissue -specific pattern among different varieties. In addition, MiSOC1 gene expression was affect by ethephon while high concentration ethephon inhibit the expression of MiSOC1. Overexpression of MiSOC1 resulted in early flowering in Arabidopsis. In conclusion, these results suggest that MiSOC1 may act as induce flower function in mango.

  4. Photoperiodic regulation of leptin sensitivity in the Siberian hamster, Phodopus sungorus, is reflected in arcuate nucleus SOCS-3 (suppressor of cytokine signaling) gene expression.

    Science.gov (United States)

    Tups, Alexander; Ellis, Claire; Moar, Kim M; Logie, Tracy J; Adam, Clare L; Mercer, Julian G; Klingenspor, Martin

    2004-03-01

    We present the first evidence that suppressor of cytokine signaling-3 (SOCS3), a protein inhibiting Janus kinase/signal transducer and activator of transcription (STAT) signaling distal of the leptin receptor, conveys seasonal changes in leptin sensitivity in the Siberian hamster. Food deprivation (48 h) reduced SOCS3 gene expression in hamsters acclimated to either long (LD) or short (SD) photoperiods, suggesting that leptin signals acute starvation regardless of photoperiod. However, SOCS3 mRNA levels were substantially lower in the hypothalamic arcuate nucleus of hamsters acclimated to SD than in those raised in LD. In juveniles raised in LD, a rapid increase in SOCS3 mRNA was observed within 4 d of weaning, which was completely prevented by transfer to SD on the day of weaning. The early increase in SOCS3 gene expression in juvenile hamsters in LD clearly preceded the establishment of different body weight trajectories in LD and SD. In adult LD hamsters, SOCS3 mRNA was maintained at an elevated level despite the chronic food restriction imposed to lower body weight and serum leptin to or even below SD levels. A single injection of leptin in SD hamsters elevated SOCS3 mRNA to LD levels, whereas leptin treatment had no effect on SOCS3 gene expression in LD hamsters. Our results suggest that the development of leptin resistance in LD-acclimated hamsters involves SOCS3-mediated suppression of leptin signaling in the arcuate nucleus. Increased SOCS3 expression in LD hamsters is independent of body fat and serum leptin levels, suggesting that the photoperiod is able to trigger the biannual reversible switch in leptin sensitivity.

  5. SHP2, SOCS3 and PIAS3 Expression Patterns in Medulloblastomas: Relevance to STAT3 Activation and Resveratrol-Suppressed STAT3 Signaling.

    Science.gov (United States)

    Li, Cong; Li, Hong; Zhang, Peng; Yu, Li-Jun; Huang, Tian-Miao; Song, Xue; Kong, Qing-You; Dong, Jian-Li; Li, Pei-Nan; Liu, Jia

    2016-12-27

    Activated STAT3 signaling is critical for human medulloblastoma cells. SHP2, SOCS3 and PIAS3 are known as the negative regulators of STAT3 signaling, while their relevance to frequent STAT3 activation in medulloblastomas remains unknown. Tissue microarrays were constructed with 17 tumor-surrounding noncancerous brain tissues and 61 cases of the classic medulloblastomas, 44 the large-cell medulloblastomas, and 15 nodular medulloblastomas, which were used for immunohistochemical profiling of STAT3, SHP2, SOCS3 and PIAS3 expression patterns and the frequencies of STAT3 nuclear translocation. Three human medulloblastoma cell lines (Daoy, UW228-2 and UW228-3) were cultured with and without 100 μM resveratrol supplementation. The influences of resveratrol in SHP2, SOCS3 and PIAS3 expression and SOCS3 knockdown in STAT3 activation were analyzed using multiple experimental approaches. SHP2, SOCS3 and PIAS3 levels are reduced in medulloblastomas in vivo and in vitro, of which PIAS3 downregulation is more reversely correlated with STAT3 activation. In resveratrol-suppressed medulloblastoma cells with STAT3 downregulation and decreased incidence of STAT3 nuclear translocation, PIAS3 is upregulated, the SHP2 level remains unchanged and SOCS3 is downregulated. SOCS3 proteins are accumulated in the distal ends of axon-like processes of resveratrol-differentiated medulloblastoma cells. Knockdown of SOCS3 expression by siRNA neither influences cell proliferation nor STAT3 activation or resveratrol sensitivity but inhibits resveratrol-induced axon-like process formation. Our results suggest that (1) the overall reduction of SHP2, SOCS3 and PIAS3 in medulloblastoma tissues and cell lines; (2) the more inverse relevance of PIAS3 expression with STAT3 activation; (3) the favorable prognostic values of PIAS3 for medulloblastomas and (4) the involvement of SOCS3 in resveratrol-promoted axon regeneration of medulloblastoma cells.

  6. Molecular Cloning, Characterization, and Expression of MiSOC1: A Homolog of the Flowering Gene SUPPRESSOR OF OVEREXPRESSION OF CONSTANS1 from Mango (Mangifera indica L)

    Science.gov (United States)

    Wei, Junya; Liu, Debing; Liu, Guoyin; Tang, Jie; Chen, Yeyuan

    2016-01-01

    MADS-box transcription factor plays a crucial role in plant development, especially controlling the formation and development of floral organs. Mango (Mangifera indica L) is an economically important fruit crop, but its molecular control of flowering is largely unknown. To better understand the molecular basis of flowering regulation in mango, we isolated and characterized the MiSOC1, a putative mango orthologs for the Arabidopsis SUPPRESSOR OF OVEREXPRESSION OF CONSTANS1/AGAMOUS-LIKE 20 (SOC1/AGL20) with homology-based cloning and RACE. The full-length cDNA (GenBank accession No.: KP404094) is 945 bp in length including a 74 bp long 5′ UTR and a 189 bp long 3′ UTR and the open reading frame was 733 bps, encoding 223 amino acids with molecular weight 25.6 kD. Both sequence alignment and phylogenetic analysis all indicated that deduced protein contained a conservative MADS-box and semi-conservative K domain and belonged to the SOC1/TM3 subfamily of the MADS-box family. Quantitative real-time PCR was performed to investigate the expression profiles of MiSOC1 gene in different tissues/organs including root, stem, leaves, flower bud, and flower. The result indicated MiSOC1 was widely expressed at different levels in both vegetative and reproductive tissues/organs with the highest expression level in the stems’ leaves and inflorescences, low expression in roots and flowers. The expression of MiSOC1 in different flower developmental stages was different while same tissue –specific pattern among different varieties. In addition, MiSOC1 gene expression was affect by ethephon while high concentration ethephon inhibit the expression of MiSOC1. Overexpression of MiSOC1 resulted in early flowering in Arabidopsis. In conclusion, these results suggest that MiSOC1 may act as induce flower function in mango. PMID:27965680

  7. How do soil quality indicators (SOC and nutrients) change with long-term different crop residue management?

    Science.gov (United States)

    Spiegel, Heide; Lehtinen, Taru; Dersch, Georg; Baumgarten, Andreas

    2016-04-01

    Leaving the crop residues (cereal grain straw, maize stover, sugar beet leaves) on the field may enhance SOC and soil nutrient contents (e.g. P, K, Mg). In contrast, harvesting crop residues for livestock bedding or energy production are often connected with a loss of soil fertility (Lehtinen et al., 2014). We have evaluated the effects of different management of crop residues on selected soil parameters of the upper soil (0-25 cm) in two long-term field experiments in Austria focused on P-dynamics (Marchfeld, since 1982 and Alpenvorland, since 1986). In four P-fertilisation stages (0, 75, 150, 300 kg P2O5 ha-1y-1) all crop residues were incorporated in one treatment and all removed in the other one, respectively. The results show that the effects are different at the two investigated sites. At the site Marchfeld, a medium textured soil, on average SOC was significantly higher with the incorporation of crop residues (21.6 g kg-1) compared to the removal (19.9 g kg-1) after 32 years. In the long run, SOC levels could be maintained, if crop residues remained at the field, whereas the constant removal of crop residues resulted in a SOC decline. At the site Alpenvorland, SOC was only slightly higher with the incorporation of the crop residues after 28 years. In this case, in the long run, even with this management practice and, moreover, with the residue removal, SOC tended to decrease generally. At the Marchfeld, crop residue incorporation resulted in a significant increase of "plant available" phosphorus (P-CAL) only with very high P fertilization. However, "plant available" Mg (according to Schachtschabel) and potassium (K-CAL) were significantly higher in all P fertilisation stages compared to the residue removal treatments. At the site Alpenvorland, the soils are rich in silt and clay and with long-term incorporation of crop residues a significant increase only of „plant available" K of about 50% occurred. This indicates the necessity of taking into account the

  8. EVERYTHING MOVES NOTHING STANDS STILL. SOME ASPECTS ABOUT THE MEGASYSTEM EARTH ECO-SOC-ECO

    Directory of Open Access Journals (Sweden)

    Negucioiu Aurel

    2012-12-01

    Full Text Available One of the most important moments of the start or restart of the academic activity has always been the opening of courses in each subject (discipline that would be studied. On these occasions each professor shows to the students the subject of the discipline, place and role that intellectual seizure of that object in the formation of their professional competence required by the exigencies of the time. Most teachers stop on the most important sources, sources of knowledge that young learners can turn to and would be better to turn. They indicate written sources, books, magazines and other publications available in classical libraries and add, especially now, the world’s largest library: the Internet. However, teachers advise students to seek permanently another source, a "book" - permanently opened, the book of reality that contains the most truth and what is very important - many problems waiting to be discovered and resolved. Leafing over "the first pages" of one of the "volumes" of this huge established "book", I found that the paradigm "Everything moves. Nothing stands still" as the paradigm "movement is absolute, and the repose - roughly" is far from having exhausted full knowledge of "everything". But knowledge can enrich through investigation of the unknown aspects. Substantially reducing the size of the unknown we have subscribed to communicate, stopping on several sides and objectives of the issues: Further examination of the main contents of the concept of development; Nominate a limited number of forms of movement in the "kingdom" of the Megasystem Eco-soc-eco; Further investigation of the causes of motion; Pace to and rhythm in which the different forms of movement develop; Which are the directions in which evolve different directions of movement forms.

  9. Soc para la identificación de variaciones morfológicas del eritrocito

    Directory of Open Access Journals (Sweden)

    Danelia Matos Molina

    2011-03-01

    Full Text Available Normal 0 21 false false false MicrosoftInternetExplorer4 st1:*{behavior:url(#ieooui } /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Tabla normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} En el presente se expone el diseño e implementación de un Sistema on Chip apropiado para el procesamiento de señales e imágenes. Este sistema puede representar parte importante en dispositivos médicos de apoyo en el diagnóstico de ciertas  enfermedades donde ocurran variaciones morfológicas en los eritrocitos, como es el caso de la Siklemia. El diseño está basado en un SoC de Plasma y un procesador MIPS Lite, se ha añadido además un núcleo FFT para el mejoramiento de los cálculos de la Transformada discreta de Fourier. Igualmente ha sido desarrollado un programa que calcula dada una imagen, la FFT de los bordes de los eritrocitos presentes.

  10. Perception SoC Based on an Ultrasonic Array of Sensors: Efficient DSP Core Implementation and Subsequent Experimental Results

    Directory of Open Access Journals (Sweden)

    A. Haidar

    2005-05-01

    Full Text Available We are concerned with the design, implementation, and validation of a perception SoC based on an ultrasonic array of sensors. The proposed SoC is dedicated to ultrasonic echography applications. A rapid prototyping platform is used to implement and validate the new architecture of the digital signal processing (DSP core. The proposed DSP core efficiently integrates all of the necessary ultrasonic B-mode processing modules. It includes digital beamforming, quadrature demodulation of RF signals, digital filtering, and envelope detection of the received signals. This system handles 128 scan lines and 6400 samples per scan line with a 90° angle of view span. The design uses a minimum size lookup memory to store the initial scan information. Rapid prototyping using an ARM/FPGA combination is used to validate the operation of the described system. This system offers significant advantages of portability and a rapid time to market.

  11. Using Mobilize Power Management IP for Dynamic & Static Power Reduction in SoC at 130 nm

    CERN Document Server

    Hillman, Dan

    2011-01-01

    At 130 nm and 90 nm, power consumption (both dynamic and static) has become a barrier in the roadmap for SoC designs targeting battery powered, mobile applications. This paper presents the results of dynamic and static power reduction achieved implementing Tensilica's 32-bit Xtensa microprocessor core, using Virtual Silicon's Power Management IP. Independent voltage islands are created using Virtual Silicon's VIP PowerSaver standard cells by using voltage level shifting cells and voltage isolation cells to implement power islands. The VIP PowerSaver standard cells are characterized at 1.2V, 1.0V and 0.8V, to accommodate voltage scaling. Power islands can also be turned off completely. Designers can significantly lower both the dynamic power and the quiescent or leakage power of their SoC designs, with very little impact on speed or area using Virtual Silicon's VIP Gate Bias standard cells.

  12. A mixed SOC-turbulence model for nonlocal transport and Lévy-fractional Fokker–Planck equation

    DEFF Research Database (Denmark)

    Juul Rasmussen, Jens; Milovanov, Alexander V.

    2014-01-01

    The phenomena of nonlocal transport in magnetically confined plasma are theoretically analyzed. A hybrid model is proposed, which brings together the notion of inverse energy cascade, typical of drift-wave- and two-dimensional fluid turbulence, and the ideas of avalanching behavior, associable...... with self-organized critical (SOC) behavior. Using statistical arguments, it is shown that an amplification mechanism is needed to introduce nonlocality into dynamics. We obtain a consistent derivation of nonlocal Fokker-Planck equation with space-fractional derivatives from a stochastic Markov process...... with the transition probabilities defined in reciprocal space. The hybrid model observes the Sparre Andersen universality and defines a new universality class of SOC. (C) 2014 Elsevier B.V. All rights reserved....

  13. Jak/Stat Signaling Stimulates Zebrafish Optic Nerve Regeneration and Overcomes the Inhibitory Actions of Socs3 and Sfpq

    Science.gov (United States)

    Elsaeidi, Fairouz; Bemben, Michael A.; Zhao, Xiao-Feng

    2014-01-01

    The regenerative failure of mammalian optic axons is partly mediated by Socs3-dependent inhibition of Jak/Stat signaling (Smith et al., 2009, 2011). Whether Jak/Stat signaling is part of the normal regenerative response observed in animals that exhibit an intrinsic capacity for optic nerve regeneration, such as zebrafish, remains unknown. Nor is it known whether the repression of regenerative inhibitors, such as Socs3, contributes to the robust regenerative response of zebrafish to optic nerve damage. Here we report that Jak/Stat signaling stimulates optic nerve regeneration in zebrafish. We found that IL-6 family cytokines, acting via Gp130-coupled receptors, stimulate Jak/Stat3 signaling in retinal ganglion cells after optic nerve injury. Among these cytokines, we found that CNTF, IL-11, and Clcf1/Crlf1a can stimulate optic axon regrowth. Surprisingly, optic nerve injury stimulated the expression of Socs3 and Sfpq (splicing factor, proline/glutamine rich) that attenuate optic nerve regeneration. These proteins were induced in a Jak/Stat-dependent manner, stimulated each other's expression and suppressed the expression of regeneration-associated genes. In vivo, the injury-dependent induction of Socs3 and Sfpq inhibits optic nerve regeneration but does not block it. We identified a robust induction of multiple cytokine genes in zebrafish retinal ganglion cells that may contribute to their ability to overcome these inhibitory factors. These studies not only identified mechanisms underlying optic nerve regeneration in fish but also suggest new molecular targets for enhancing optic nerve regeneration in mammals. PMID:24523552

  14. A fully-integrated high-compliance voltage SoC for epi-retinal and neural prostheses.

    Science.gov (United States)

    Lo, Yi-Kai; Chen, Kuanfu; Gad, Parag; Liu, Wentai

    2013-12-01

    This paper presents a fully functionally integrated 1024-channel mixed-mode and mixed-voltage system-on-a-chip (SoC) for epi-retinal and neural prostheses. Taking an AC input, an integrated power telemetry circuits is capable of generating multiple DC voltages with a voltage conversion efficiency of 83% at a load of 100 mW without external diodes or separate power integrated circuits, reducing the form factor of the prosthetic device. A wireless DPSK receiver with a novel noise reduction scheme supports a data rate of 2 Mb/s at a bit-error-rate of 2 ×10⁻⁷. The 1024-channel stimulator array meets an output compliance voltage of ±10 V and provides flexible stimulation waveforms. Through chip-clustering, the stimulator array can be further expanded to 4096 channels. This SoC is designed and fabricated in TSMC 0.18 μm high-voltage 32 V CMOS process and occupies a chip area of 5.7 mm × 6.6 mm. Using this SoC, a retinal implant bench-top test system is set up with real-time visual verification. In-vitro experiment conducted in artificial vitreous humor is designed and set-up to investigate stimulation waveforms for better visual resolution. In our in-vivo experiment, a hind-limb paralyzed rat with spinal cord transection and implanted chronic epidural electrodes has been shown to regain stepping and standing abilities using stimulus provided by the SoC.

  15. Highly monodisperse M III-based soc -MOFs (M = in and Ga) with cubic and truncated cubic morphologies

    KAUST Repository

    Pang, Maolin

    2012-08-15

    In this work, we carry out an investigation on shape-controlled growth of In III- and Ga III-based square-octahedral metal-organic frameworks (soc-MOFs). In particular, controllable crystal morphological evolution from simple cubes to complex octadecahedra has been achieved, and resultant highly uniform crystal building blocks promise new research opportunities for preparation of self-assembled MOF materials and related applications. © 2012 American Chemical Society.

  16. CCR5 Blockade Suppresses Melanoma Development Through Inhibition of IL-6-Stat3 Pathway via Upregulation of SOCS3.

    Science.gov (United States)

    Tang, Qiu; Jiang, Jun; Liu, Jian

    2015-12-01

    In order to understand how tumor cells can escape immune surveillance mechanisms and thus develop antitumor therapies, it is critically important to investigate the mechanisms by which the immune system interacts with the tumor microenvironment. In our current study, we found that chemokine receptor 5 (CCR5) neutralization resulted in reduced melanoma tumor size, decreased percentage of CD11b+ Gr-1(+) myeloid-derived suppressor cells (MDSCs), and increased proportion of cluster of differentiation (CD)3+ T cells in tumor tissues. Suppressive activity of MDSCs on CD4+ T cells and CD8+ T cell proliferation is significantly inhibited by anti-CCR5 antibody. CCR5 blockade also suppresses interleukin (IL)-6 induction, which in turn deactivates signal transducer and activator of transcription 3 (Stat3) in tumors. Furthermore, the suppressed B16 tumor growth induced by CCR5 blockade is abolished with additional administration of recombinant IL-6. CCR5 blockade also induces suppressor of cytokine signaling 3 (SOCS3) upregulations, and anti-CCR5 antibody fails to suppress expression of phospho-Stat3 (p-Stat3), matrix metallopeptidase 9 (MMP9), and IL-6 in cells transfected with SOCS3 short-interfering RNA (SiRNA). All these data suggest that CCR5 blockade suppresses melanoma development through inhibition of IL-6-Stat3 pathway via upregulation of SOCS3.

  17. Silencing of FGF-21 expression promotes hepatic gluconeogenesis and glycogenolysis by regulation of the STAT3-SOCS3 signal.

    Science.gov (United States)

    Wang, Cong; Dai, Jihuan; Yang, Mengliu; Deng, Guangjiang; Xu, Shengnan; Jia, Yanjun; Boden, Guenther; Ma, Zhongmin A; Yang, Gangyi; Li, Ling

    2014-05-01

    Insulin resistance is a metabolic disorder associated with type 2 diabetes. Recent reports have shown that fibroblast growth factor-21 (FGF-21) plays an important role in the progression of insulin resistance. However, the biochemical and molecular mechanisms by which changes in FGF-21 activation result in changes in the rates of hepatic gluconeogenesis and glycogenolysis remain to be elucidated. In this study, we developed adenovirus-mediated shRNA against FGF-21 to inhibit FGF-21 expression in ApoE knockout mice. Using this mouse model, we determined the effects of FGF-21 knockdown in vivo on hepatic glucose production, gluconeogenesis and glycogenolysis, and their relationship with the signal transducer and activator of transcription 3 (STAT3)/suppressor of cytokine signaling 3 (SOCS3) signal pathways. We show that liver-specific knockdown of FGF-21 in high-fat diet-fed ApoE knockout mice resulted in a 39% increase in glycogenolysis and a 75% increase in gluconeogenesis, accompanied by increased hepatic expression of glucose-6-phosphatase and phosphoenolpyruvate carboxykinase. Furthermore, FGF-21 knockdown decreased phosphorylation of STAT3 and SOCS3 expression in high-fat diet-fed mice. Our data suggest that hepatic FGF-21 knockdown increases gluconeogenesis and glycogenolysis by activation of glucose-6-phosphatase and phosphoenolpyruvate carboxykinase via the STAT3/SOCS3 pathway, ultimately leading to exacerbation of hepatic insulin resistance.

  18. System on chip (SoC) microcontrollers (μC) as digitisers for ion beam analysis (IBA) instruments

    Science.gov (United States)

    Whitlow, Harry J.

    2016-09-01

    Data digitisation of the analogue signals from detectors to digital data is an essential process in ion beam analysis (IBA). The low-cost, easy availability and development environments that have a low learning threshold makes system-on-chip (SoC) microcontrollers (μC) attractive for this task. These μC combine, on one die, analogue and digital inputs and outputs with serial USB interfaces, which opens up simple implementation of tailor-made interfaces for specific IBA measurement systems. We have investigated the design and performance limitations based on development of three different digitisation interfaces for IBA. These were a two-channel nuclear instrumentation module (NIM) ADC event mode interface (EMI) for a high-resolution magnetic RBS spectrometer, a simple headless-multi-channel analyser (MCA) and a combined dual channel headless MCA and EMI. It is shown that SoC μC based interfaces for digitisation of analogue spectroscopy pulses in IBA systems can be implemented for material costs less than 100 €. The performance of the SoC devices for many IBA applications is close to what can be achieved with state-of-the-art instruments. The simple pulse spectroscopy interface circuit and software are included in the auxiliary archive.

  19. Sequential action of FRUITFULL as a modulator of the activity of the floral regulators SVP and SOC1.

    Science.gov (United States)

    Balanzà, Vicente; Martínez-Fernández, Irene; Ferrándiz, Cristina

    2014-03-01

    The role in flowering time of the MADS-box transcription factor fruitfulL (FUL) has been proposed in many works. FUL has been connected to several flowering pathways as a target of the photoperiod, ambient temperature, and age pathways and it is has been shown to promote flowering in a partially redundant manner with suppressor of overexpression of constans 1 (SOC1). However, the position of FUL in these genetic networks, as well as the functional output of FUL activity during floral transition, remains unclear. In this work, a genetic approach has been undertaken to understand better the functional hierarchies involving FUL and other MADS-box factors with well established roles as floral integrators such as SOC1, short vegetative phase (svp) or flowering locus C (FLC). Our results suggest a prominent role of FUL in promoting reproductive transition when photoinductive signalling is suppressed by short-day conditions or by high levels of FLC expression, as in non-vernalized winter ecotypes. A model is proposed where the sequential formation of FUL-SVP and FUL-SOC1 heterodimers may mediate the vegetative and meristem identity transitions, counteracting the repressive effect of FLC and SVP on flowering.

  20. Generic System Verilog Universal Verification Methodology Based Reusable Verification Environment for Efficient Verification of Image Signal Processing IPS/SOCS

    Directory of Open Access Journals (Sweden)

    Abhishek Jain

    2012-12-01

    Full Text Available In this paper, we present Generic System Verilog Universal Verification Methodology based Reusable Verification Environment for efficient verification of Image Signal Processing IP’s/SoC’s. With the tight schedules on all projects it is important to have a strong verification methodology which contributes to First Silicon Success. Deploy methodologies which enforce full functional coverage and verification of corner cases through pseudo random test scenarios is required. Also, standardization of verification flow is needed. Previously, inside imaging group of ST, Specman (e/Verilog based Verification Environment forIP/Subsystem level verification and C/C++/Verilog based Directed Verification Environment for SoC Level Verification was used for Functional Verification. Different Verification Environments were used at IP level and SoC level. Different Verification/Validation Methodologies were used for SoC Verification across multiple sites. Verification teams were also looking for the ways how to catch bugs early in the design cycle? Thus, Generic System Verilog Universal Verification Methodology (UVM based Reusable Verification Environment is required to avoid the problem of having so many methodologies and provides a standard unified solution which compiles on all tools.

  1. A Fully-Implantable Cochlear Implant SoC with Piezoelectric Middle-Ear Sensor and Arbitrary Waveform Neural Stimulation.

    Science.gov (United States)

    Yip, Marcus; Jin, Rui; Nakajima, Hideko Heidi; Stankovic, Konstantina M; Chandrakasan, Anantha P

    2015-01-01

    A system-on-chip for an invisible, fully-implantable cochlear implant is presented. Implantable acoustic sensing is achieved by interfacing the SoC to a piezoelectric sensor that detects the sound-induced motion of the middle ear. Measurements from human cadaveric ears demonstrate that the sensor can detect sounds between 40 and 90 dB SPL over the speech bandwidth. A highly-reconfigurable digital sound processor enables system power scalability by reconfiguring the number of channels, and provides programmable features to enable a patient-specific fit. A mixed-signal arbitrary waveform neural stimulator enables energy-optimal stimulation pulses to be delivered to the auditory nerve. The energy-optimal waveform is validated with in-vivo measurements from four human subjects which show a 15% to 35% energy saving over the conventional rectangular waveform. Prototyped in a 0.18 μm high-voltage CMOS technology, the SoC in 8-channel mode consumes 572 μW of power including stimulation. The SoC integrates implantable acoustic sensing, sound processing, and neural stimulation on one chip to minimize the implant size, and proof-of-concept is demonstrated with measurements from a human cadaver ear.

  2. A Low Power SOC Architecture for the V2.0+EDR Bluetooth Using a Unified Verification Platform

    Science.gov (United States)

    Kim, Jeonghun; Kim, Suki; Baek, Kwang-Hyun

    This paper presents a low-power System on Chip (SOC) architecture for the v2.0+EDR (Enhanced Data Rate) Bluetooth and its applications. Our design includes a link controller, modem, RF transceiver, Sub-Band Codec (SBC), Expanded Instruction Set Computer (ESIC) processor, and peripherals. To decrease power consumption of the proposed SOC, we reduce data transfer using a dual-port memory, including a power management unit, and a clock gated approach. We also address some of issues and benefits of reusable and unified environment on a centralized data structure and SOC verification platform. This includes flexibility in meeting the final requirements using technology-independent tools wherever possible in various processes and for projects. The other aims of this work are to minimize design efforts by avoiding the same work done twice by different people and to reuse the similar environment and platform for different projects. This chip occupies a die size of 30mm2 in 0.18µm CMOS, and the worst-case current of the total chip is 54mA.

  3. Neurochemostat: A Neural Interface SoC With Integrated Chemometrics for Closed-Loop Regulation of Brain Dopamine.

    Science.gov (United States)

    Bozorgzadeh, Bardia; Schuweiler, Douglas R; Bobak, Martin J; Garris, Paul A; Mohseni, Pedram

    2016-06-01

    This paper presents a 3.3×3.2 mm(2) system-on-chip (SoC) fabricated in AMS 0.35 μm 2P/4M CMOS for closed-loop regulation of brain dopamine. The SoC uniquely integrates neurochemical sensing, on-the-fly chemometrics, and feedback-controlled electrical stimulation to realize a "neurochemostat" by maintaining brain levels of electrically evoked dopamine between two user-set thresholds. The SoC incorporates a 90 μW, custom-designed, digital signal processing (DSP) unit for real-time processing of neurochemical data obtained by 400 V/s fast-scan cyclic voltammetry (FSCV) with a carbon-fiber microelectrode (CFM). Specifically, the DSP unit executes a chemometrics algorithm based upon principal component regression (PCR) to resolve in real time electrically evoked brain dopamine levels from pH change and CFM background-current drift, two common interferents encountered using FSCV with a CFM in vivo. Further, the DSP unit directly links the chemically resolved dopamine levels to the activation of the electrical microstimulator in on-off-keying (OOK) fashion. Measured results from benchtop testing, flow injection analysis (FIA), and biological experiments with an anesthetized rat are presented.

  4. Inactivation of SOCS3 in leptin receptor-expressing cells protects mice from diet-induced insulin resistance but does not prevent obesitya

    Science.gov (United States)

    Pedroso, João A.B.; Buonfiglio, Daniella C.; Cardinali, Lais I.; Furigo, Isadora C.; Ramos-Lobo, Angela M.; Tirapegui, Julio; Elias, Carol F.; Donato, Jose

    2014-01-01

    Therapies that improve leptin sensitivity have potential as an alternative treatment approach against obesity and related comorbidities. We investigated the effects of Socs3 gene ablation in different mouse models to understand the role of SOCS3 in the regulation of leptin sensitivity, diet-induced obesity (DIO) and glucose homeostasis. Neuronal deletion of SOCS3 partially prevented DIO and improved glucose homeostasis. Inactivation of SOCS3 only in LepR-expressing cells protected against leptin resistance induced by HFD, but did not prevent DIO. However, inactivation of SOCS3 in LepR-expressing cells protected mice from diet-induced insulin resistance by increasing hypothalamic expression of Katp channel subunits and c-Fos expression in POMC neurons. In summary, the regulation of leptin signaling by SOCS3 orchestrates diet-induced changes on glycemic control. These findings help to understand the molecular mechanisms linking obesity and type 2 diabetes, and highlight the potential of SOCS3 inhibitors as a promising therapeutic approach for the treatment of diabetes. PMID:25161884

  5. MOF Crystal Chemistry Paving the Way to Gas Storage Needs: Aluminum Based soc-MOF for CH4, O2 and CO2 Storage

    KAUST Repository

    Alezi, Dalal

    2015-09-28

    The molecular building block approach was employed effectively to construct a series of novel isoreticular, highly porous and stable, aluminum based Metal-Organic Frameworks with soc topology. From this platform, three compounds were experimentally isolated and fully characterized, namely, the parent Al-soc-MOF-1 and its naphthalene and anthracene analogues. Al-soc-MOF-1 exhibits outstanding gravimetric methane uptake (total and working capacity). It is shown experimentally, for the first time, that the Al-soc-MOF platform can address the challenging Department of Energy dual target of 0.5 g/g (gravimetric) and 264 cm3 (STP)/cm3 (volumetric) methane storage. Furthermore, Al-soc-MOF exhibited the highest total gravimetric and volumetric uptake for carbon dioxide and the utmost total and deliverable uptake for oxygen at relatively high pressures among all microporous MOFs. In order to correlate the MOF pore structure and functionality to the gas storage properties, to better understand the structure-properties relationship, we performed a molecular simulation study and evaluated the methane storage performance of Al-soc-MOF platform using diverse organic linkers. It was found that shortening the parent Al-soc-MOF-1 linker resulted in a noticeable enhancement in the working volumetric capacity at specific temperatures and pressures with amply conserved gravimetric uptake/working capacity. In contrast, further expansion of the organic linker (branches and/or core) led to isostructural Al-soc-MOFs with enhanced gravimetric uptake but noticeably lower volumetric capacity. The collective experimental and simulation studies indicated that the parent Al-soc-MOF-1 exhibits the best compromise between the volumetric and gravimetric total and working uptakes in a wide range of pressure and temperature conditions.

  6. MOF Crystal Chemistry Paving the Way to Gas Storage Needs: Aluminum-Based soc-MOF for CH4, O2, and CO2 Storage.

    Science.gov (United States)

    Alezi, Dalal; Belmabkhout, Youssef; Suyetin, Mikhail; Bhatt, Prashant M; Weseliński, Łukasz J; Solovyeva, Vera; Adil, Karim; Spanopoulos, Ioannis; Trikalitis, Pantelis N; Emwas, Abdul-Hamid; Eddaoudi, Mohamed

    2015-10-21

    The molecular building block approach was employed effectively to construct a series of novel isoreticular, highly porous and stable, aluminum-based metal-organic frameworks with soc topology. From this platform, three compounds were experimentally isolated and fully characterized: namely, the parent Al-soc-MOF-1 and its naphthalene and anthracene analogues. Al-soc-MOF-1 exhibits outstanding gravimetric methane uptake (total and working capacity). It is shown experimentally, for the first time, that the Al-soc-MOF platform can address the challenging Department of Energy dual target of 0.5 g/g (gravimetric) and 264 cm(3) (STP)/cm(3) (volumetric) methane storage. Furthermore, Al-soc-MOF exhibited the highest total gravimetric and volumetric uptake for carbon dioxide and the utmost total and deliverable uptake for oxygen at relatively high pressures among all microporous MOFs. In order to correlate the MOF pore structure and functionality to the gas storage properties, to better understand the structure-property relationship, we performed a molecular simulation study and evaluated the methane storage performance of the Al-soc-MOF platform using diverse organic linkers. It was found that shortening the parent Al-soc-MOF-1 linker resulted in a noticeable enhancement in the working volumetric capacity at specific temperatures and pressures with amply conserved gravimetric uptake/working capacity. In contrast, further expansion of the organic linker (branches and/or core) led to isostructural Al-soc-MOFs with enhanced gravimetric uptake but noticeably lower volumetric capacity. The collective experimental and simulation studies indicated that the parent Al-soc-MOF-1 exhibits the best compromise between the volumetric and gravimetric total and working uptakes under a wide range of pressure and temperature conditions.

  7. Shrimp with knockdown of LvSOCS2, a negative feedback loop regulator of JAK/STAT pathway in Litopenaeus vannamei, exhibit enhanced resistance against WSSV.

    Science.gov (United States)

    Wang, Sheng; Song, Xuan; Zhang, Zijian; Li, Haoyang; L, Kai; Yin, Bin; He, Jianguo; Li, Chaozheng

    2016-12-01

    JAK/STAT pathway is one of cytokine signaling pathways and mediates diversity immune responses to protect host from viral infection. In this study, LvSOCS2, a member of suppressor of cytokine signaling (SOCS) families, has been cloned and identified from Litopenaeus vannamei. The full length of LvSOCS2 is 1601 bp, including an 1194 bp open reading frame (ORF) coding for a putative protein of 397 amino acids with a calculated molecular weight of ∼42.3 kDa. LvSOCS2 expression was most abundant in gills and could respond to the challenge of LPS, Vibrio parahaemolyticus, Staphhylococcus aureus, Poly (I: C) and white spot syndrome virus (WSSV). There are several STAT binding motifs presented in the proximal promoter region of LvSOCS2 and its expression was induced by LvJAK or LvSTAT protein in a dose dependent manner, suggesting LvSOCS2 could be the transcriptional target gene of JAK/STAT pathway. Moreover, the transcription of DmVir-1, a read out of the activation of JAK/STAT pathway in Drosophila, was promoted by LvJAK but inhibited by LvSOCS2, indicating that LvSOCS2 could be a negative regulator in this pathway and thus can form a negative feedback loop. Our previous study indicated that shrimp JAK/STAT pathway played a positive role against WSSV. In this study, RNAi-mediated knockdown of LvSOCS2 shrimps showed lower susceptibility to WSSV infection and caused lessened virus loads, which further demonstrated that the JAK/STAT pathway could function as an anti-viral immunity in shrimp.

  8. The suppressor of cytokine signalling 3, SOCS3, may be one critical modulator of seasonal body weight changes in the Siberian hamster, Phodopus sungorus.

    Science.gov (United States)

    Tups, A; Barrett, P; Ross, A W; Morgan, P J; Klingenspor, M; Mercer, J G

    2006-02-01

    The Siberian hamster, Phodopus sungorus, exhibits a remarkable cycle of body weight, reproduction and leptin sensitivity in response to a seasonal change in photoperiod. In the present study, we investigated the hypothesis that the suppressor of cytokine signalling 3 (SOCS3) plays a critical role in the regulation of the seasonal body weight cycle. We analysed arcuate nucleus SOCS3 gene expression in short day length (SD; 8 : 16 h light/dark) acclimated Siberian hamsters that were transferred back to long day length (LD; 16 : 8 h light/dark) and in hamsters that spontaneously became photorefractory to SD induced by prolonged exposure. SD acclimated hamsters that were transferred back to LD for 1, 2, 3, 4 or 6 weeks, increased arcuate nucleus SOCS3 gene expression to the LD level within 2 weeks, and maintained this higher level thereafter. The early increase of SOCS3 gene expression preceded the LD-induced rise in body weight by approximately 3 weeks. Hamsters kept in SD for an extended period (25 weeks), began to become refractory to SD and to increase body weight. By this time, there was no difference in level of SOCS3 gene expression between LD and SD photoperiods, although body weight was still suppressed in SD hamsters. Finally, we addressed whether SOCS3 gene expression is related to SD-induced gonadal regression or to body weight decrease by comparing Siberian hamsters with Syrian hamsters. The latter exhibited substantial SD-induced gonadal regression but only limited seasonal changes in body weight. Acclimation to either LD or SD for 14 weeks had no effect on SOCS3 gene expression. This implies that arcuate nucleus SOCS3 gene expression is unlikely to be related to seasonal cycles in reproductive activity. Taken together, the findings further strengthen our hypothesis that SOCS3 may be one molecular trigger of seasonal cycles in body weight.

  9. Assessing SOC labile fractions through respiration test, density-size fractionation and thermal analysis - A comparison of methods

    Science.gov (United States)

    Soucemarianadin, Laure; Cécillon, Lauric; Chenu, Claire; Baudin, François; Nicolas, Manuel; Savignac, Florence; Barré, Pierre

    2017-04-01

    Soil organic matter (SOM) is the biggest terrestrial carbon reservoir, storing 3 to 4 times more carbon than the atmosphere. However, despite its major importance for climate regulation SOM dynamics remains insufficiently understood. For instance, there is still no widely accepted method to assess SOM lability. Soil respiration tests and particulate organic matter (POM) obtained by different fractionation schemes have been used for decades and are now considered as classical estimates of very labile and labile soil organic carbon (SOC), respectively. But the pertinence of these methods to characterize SOM turnover can be questioned. Moreover, they are very time-consuming and their reproducibility might be an issue. Alternate ways of determining the labile SOC component are thus well-needed. Thermal analyses have been used to characterize SOM among which Rock-Eval 6 (RE6) analysis of soil has shown promising results in the determination of SOM biogeochemical stability (Gregorich et al., 2015; Barré et al., 2016). Using a large set of samples of French forest soils representing contrasted pedoclimatic conditions, including deep samples (up to 1 m depth), we compared different techniques used for SOM lability assessment. We explored whether results from soil respiration test (10-week laboratory incubations), SOM size-density fractionation and RE6 thermal analysis were comparable and how they were correlated. A set of 222 (respiration test and RE6), 103 (SOM fractionation and RE6) and 93 (respiration test, SOM fractionation and RE6) forest soils samples were respectively analyzed and compared. The comparison of the three methods (n = 93) using a principal component analysis separated samples from the surface (0-10 cm) and deep (40-80 cm) layers, highlighting a clear effect of depth on the short-term persistence of SOC. A correlation analysis demonstrated that, for these samples, the two classical methods of labile SOC determination (respiration and SOM fractionation

  10. Arqueología del cielo. Orientaciones astronómicas en edificios protohistóricos del sur de la Península Ibérica

    Directory of Open Access Journals (Sweden)

    Esteban, César

    2013-06-01

    Full Text Available We present an archaeoastronomical analysis of the orientations of six protohistoric sanctuaries and public buildings located in archaeological sites of the south of the Iberian Peninsula (Coria del Río, El Carambolo, Saltillo, Mesa de Setefilla, Tejada la Vieja and El Oral. This study, the first of its kind conducted on a sample of Early Iron Age sanctuaries in this geographic area, is based on the accurate measurement of the orientations defined by the buildings and the analysis of the horizon around them and reveals clear astronomical relations. In particular, religious buildings show similar characteristics and orientation towards an azimuth of 55°. The regularities found seem to suggest the existence of religious beliefs and rituals linked to singular positions of the brightest celestial bodies as the Sun, Moon or Venus.Presentamos un análisis arqueoastronómico de la orientación de seis santuarios y edificios de carácter público protohistóricos en sitios arqueológicos situados en el mediodía de la Península Ibérica (Coria del Río, El Carambolo, Saltillo, Mesa de Setefilla, Tejada la Vieja y El Oral. El estudio, el primero de este tipo que se realiza sobre una muestra de santuarios del Hierro Antiguo en esta área geográfica, se basa en la medida precisa de las orientaciones definidas por los edificios y el análisis del horizonte que les rodea y revela claros vínculos astronómicos. En particular, los edificios de culto muestran unas características similares y una orientación hacia un acimut de 55°. Las regularidades encontradas parecen sugerir la posible existencia de credos y rituales religiosos relacionados con posiciones singulares de los astros principales visibles a simple vista, como el Sol, la Luna o Venus.

  11. Rock-Eval analysis of French forest soils: the influence of depth, soil and vegetation types on SOC thermal stability and bulk chemistry

    Science.gov (United States)

    Soucemarianadin, Laure; Cécillon, Lauric; Baudin, François; Cecchini, Sébastien; Chenu, Claire; Mériguet, Jacques; Nicolas, Manuel; Savignac, Florence; Barré, Pierre

    2017-04-01

    Soil organic matter (SOM) is the largest terrestrial carbon pool and SOM degradation has multiple consequences on key ecosystem properties like nutrients cycling, soil emissions of greenhouse gases or carbon sequestration potential. With the strong feedbacks between SOM and climate change, it becomes particularly urgent to develop reliable routine methodologies capable of indicating the turnover time of soil organic carbon (SOC) stocks. Thermal analyses have been used to characterize SOM and among them, Rock-Eval 6 (RE6) analysis of soil has shown promising results in the determination of in-situ SOC biogeochemical stability. This technique combines a phase of pyrolysis followed by a phase of oxidation to provide information on both the SOC bulk chemistry and thermal stability. We analyzed with RE6 a set of 495 soils samples from 102 permanent forest sites of the French national network for the long-term monitoring of forest ecosystems (''RENECOFOR'' network). Along with covering pedoclimatic variability at a national level, these samples include a range of 5 depths up to 1 meter (0-10 cm, 10-20 cm, 20-40 cm, 40-80 cm and 80-100 cm). Using RE6 parameters that were previously shown to be correlated to short-term (hydrogen index, HI; T50 CH pyrolysis) or long-term (T50 CO2 oxidation and HI) SOC persistence, and that characterize SOM bulk chemical composition (oxygen index, OI and HI), we tested the influence of depth (n = 5), soil class (n = 6) and vegetation type (n = 3; deciduous, coniferous-fir, coniferous-pine) on SOM thermal stability and bulk chemistry. Results showed that depth was the dominant discriminating factor, affecting significantly all RE6 parameters. With depth, we observed a decrease of the thermally labile SOC pool and an increase of the thermally stable SOC pool, along with an oxidation and a depletion of hydrogen-rich moieties of the SOC. Soil class and vegetation type had contrasted effects on the RE6 parameters but both affected significantly T

  12. Detecting small-scale spatial differences and temporal dynamics of soil organic carbon (SOC) stocks: a comparison between automatic chamber-derived C budgets and repeated soil inventories

    Science.gov (United States)

    Hoffmann, Mathias; Jurisch, Nicole; Garcia Alba, Juana; Albiac Borraz, Elisa; Schmidt, Marten; Huth, Vytas; Rogasik, Helmut; Rieckh, Helene; Verch, Gernot; Sommer, Michael; Augustin, Jürgen

    2017-04-01

    Carbon (C) sequestration in soils plays a key role in the global C cycle. It is therefore crucial to adequately monitor dynamics in soil organic carbon (ΔSOC) stocks when aiming to reveal underlying processes and potential drivers. However, small-scale spatial and temporal changes in SOC stocks, particularly pronounced on arable lands, are hard to assess. The main reasons for this are limitations of the well-established methods. On the one hand, repeated soil inventories, often used in long-term field trials, reveal spatial patterns and trends in ΔSOC but require a longer observation period and a sufficient number of repetitions. On the other hand, eddy covariance measurements of C fluxes towards a complete C budget of the soil-plant-atmosphere system may help to obtain temporal ΔSOC patterns but lack small-scale spatial resolution. To overcome these limitations, this study presents a reliable method to detect both short-term temporal as well as small-scale spatial dynamics of ΔSOC. Therefore, a combination of automatic chamber (AC) measurements of CO2 exchange and empirically modeled aboveground biomass development (NPPshoot) was used. To verify our method, results were compared with ΔSOC observed by soil resampling. AC measurements were performed from 2010 to 2014 under a silage maize/winter fodder rye/sorghum-Sudan grass hybrid/alfalfa crop rotation at a colluvial depression located in the hummocky ground moraine landscape of NE Germany. Widespread in large areas of the formerly glaciated Northern Hemisphere, this depression type is characterized by a variable groundwater level (GWL) and pronounced small-scale spatial heterogeneity in soil properties, such as SOC and nitrogen (Nt). After monitoring the initial stage during 2010, soil erosion was experimentally simulated by incorporating topsoil material from an eroded midslope soil into the plough layer of the colluvial depression. SOC stocks were quantified before and after soil manipulation and at the end

  13. Matrine suppresses airway inflammation by downregulating SOCS3 expression via inhibition of NF-κB signaling in airway epithelial cells and asthmatic mice

    Energy Technology Data Exchange (ETDEWEB)

    Sun, Daqing [Department of Respiration, Xi’an Children’s Hospital, Xi’an 710003 (China); Wang, Jing [Department of Neonatology, Xi’an Children’s Hospital, Xi’an 710003 (China); Yang, Niandi [Outpatient Department, School of Aerospace Engineering, Air Force Engineering University, Xi’an 710038 (China); Ma, Haixin, E-mail: drhaixinma@163.com [Department of Quality Control, Xi’an Children’s Hospital, Xi’an 710003 (China)

    2016-08-12

    Matrine has been demonstrated to attenuate allergic airway inflammation. Elevated suppressor of cytokine signaling 3 (SOCS3) was correlated with the severity of asthma. The aim of this study was to investigate the effect of matrine on SOCS3 expression in airway inflammation. In this study, we found that matrine significantly inhibited OVA-induced AHR, inflammatory cell infiltration, goblet cell differentiation, and mucous production in a dose-dependent manner in mice. Matrine also abrogated the level of interleukin (IL)-4 and IL-13, but enhanced interferon (IFN)-γ expression, both in BALF and in lung homogenates. Furthermore, matrine impeded TNF-α-induced the expression of IL-6 and adhesion molecules in airway epithelial cells (BEAS-2B and MLE-12). Additionally, we found that matrine inhibited SOCS3 expression, both in asthmatic mice and TNF-α-stimulated epithelial cells via suppression of the NF-κB signaling pathway by using pcDNA3.1-SOCS3 plasmid, SOCS3 siRNA, or nuclear factor kappa-B (NF-κB) inhibitor PDTC. Conclusions: Matrine suppresses airway inflammation by downregulating SOCS3 expression via inhibition of NF-κB signaling in airway epithelial cells and asthmatic mice. - Highlights: • Matrine attenuates asthmatic symptoms and regulates Th1/Th2 balance in vivo. • Matrine suppresses inflammation responses in vitro. • Matrine decreases SOCS3 expression both in vivo and in vitro. • Matrine inhibits SOCS3 expression by suppressing NF-κB signaling.

  14. Load displacement and high speed nanoindentation data set at different state of charge (SoC) for spinel Li x Mn2O4 cathodes.

    Science.gov (United States)

    Mughal, Muhammad Zeeshan; Moscatelli, Riccardo; Sebastiani, Marco

    2016-09-01

    Novel high speed nanoindentation data is reported for 0% and 100% state of charge (SoC) for the spinal Li x Mn2O4 material. The article also includes the load/displacement data for different SoC highlighting the displacement bursts corresponding to the pillar splitting for fracture toughness evaluation. For more details, please see the article; Mughal et al. (2016) [1].

  15. Decreased Expression of Vitamin D Receptor Affects an Immune Response in Primary Biliary Cholangitis via the VDR-miRNA155-SOCS1 Pathway

    Science.gov (United States)

    Kempinska-Podhorodecka, Agnieszka; Milkiewicz, Malgorzata; Wasik, Urszula; Ligocka, Joanna; Zawadzki, Michał; Krawczyk, Marek; Milkiewicz, Piotr

    2017-01-01

    Primary biliary cholangitis (PBC) is an immune-mediated cholestatic disease. Vitamin D receptor (VDR)-dependent signaling constrains an inflammatory response by targeting the miRNA155-SOCS1 (suppressor of cytokine signaling 1) axis. The VDR-miRNA155-SOCS1 pathway was investigated in the context of the autoimmune response associated with PBC. Human liver tissues from non-cirrhotic PBC (n = 22), cirrhotic PBC (n = 22), cirrhotic primary sclerosing cholangitis (PSC, n = 13), controls (n = 23), and peripheral blood mononuclear cells (PBMC) obtained from PBC (n = 16) and PSC (n = 10) patients and healthy subjects (n = 11) were used for molecular analyses. VDR mRNA and protein expressions were substantially reduced in PBC livers (51% and 59%, respectively). Correspondingly, the decrease of SOCS1 protein expression in PBC livers, after normalization to a marker of lymphocytes and forkhead family transcriptional regulator box P3 (FOXP3, marker of Treg), was observed, and this phenomenon was accompanied by enhanced miRNA155 expression. In PSC livers, protein expressions of VDR and SOCS1 were comparable to the controls. However, in PBM cells, protein expressions of VDR and SOCS1 were considerably decreased in both PBC and PSC. We demonstrated that VDR/miRNA155-modulated SOCS1 expression is decreased in PBC which may lead to insufficient negative regulation of cytokine signaling. These findings suggest that the decreased VDR signaling in PBC could be of importance in the pathogenesis of PBC. PMID:28146070

  16. Reconstruction of an active SOCS3-based E3 ubiquitin ligase complex in vitro: identification of the active components and JAK2 and gp130 as substrates.

    Science.gov (United States)

    Kershaw, Nadia J; Laktyushin, Artem; Nicola, Nicos A; Babon, Jeffrey J

    2014-02-01

    SOCS3 (suppressor of cytokine signaling 3) inhibits the intracellular signaling cascade initiated by exposure of cells to cytokines. SOCS3 regulates signaling via two distinct mechanisms: directly inhibiting the catalytic activity of Janus kinases (JAKs) that initiate the intracellular signaling cascade and catalysing the ubiquitination of signaling components by recruiting components of an E3 ubiquitin ligase complex. Here we investigate the latter mode-of-action biochemically by reconstructing a SOCS3-based E3 ubiquitin ligase complex in vitro using fully purified, recombinant components and examining its ability to promote the ubiquitination of molecules involved in the cytokine signaling cascade. We show that SOCS3 is an active substrate recruitment module for a Cullin5-based E3 ligase and have defined the core protein components required for ubiquitination. SOCS3-induced polyubiquitination was rapid and could proceed through a number of different ubiquitin lysines. SOCS3 catalyzed the ubiquitination of both the IL-6 receptor common chain (gp130) and JAK2.

  17. Topical administration of a suppressor of cytokine signaling-1 (SOCS1) mimetic peptide inhibits ocular inflammation and mitigates ocular pathology during mouse uveitis.

    Science.gov (United States)

    He, Chang; Yu, Cheng-Rong; Sun, Lin; Mahdi, Rashid M; Larkin, Joseph; Egwuagu, Charles E

    2015-08-01

    Uveitis is a diverse group of potentially sight-threatening intraocular inflammatory diseases and pathology derives from sustained production of pro-inflammatory cytokines in the optical axis. Although topical or systemic steroids are effective therapies, their adverse effects preclude prolonged usage and are impetus for seeking alternative immunosuppressive agents, particularly for patients with refractory uveitis. In this study, we synthesized a 16 amino acid membrane-penetrating lipophilic suppressor of cytokine signaling 1 peptide (SOCS1-KIR) that inhibits JAK/STAT signaling pathways and show that it suppresses and ameliorates experimental autoimmune uveitis (EAU), the mouse model of human uveitis. Fundus images, histological and optical coherence tomography analysis of eyes showed significant suppression of clinical disease, with average clinical score of 0.5 compared to 2.0 observed in control mice treated with scrambled peptide. We further show that SOCS1-KIR conferred protection from ocular pathology by inhibiting the expansion of pathogenic Th17 cells and inhibiting trafficking of inflammatory cells into the neuroretina during EAU. Dark-adapted scotopic and photopic electroretinograms further reveal that SOCS1-KIR prevented decrement of retinal function, underscoring potential neuroprotective effects of SOCS1-KIR in uveitis. Importantly, SOCS1-KIR is non-toxic, suggesting that topical administration of SOCS1-Mimetics can be exploited as a non-invasive treatment for uveitis and for limiting cytokine-mediated pathology in other ocular inflammatory diseases including scleritis.

  18. Approximation to SOC stocks variations over time affected by land use changes in a Mediterranean mountain agricultural catchment

    Science.gov (United States)

    Lizaga, Ivan; Quijano, Laura; Gaspar, Leticia; Navas, Ana

    2017-04-01

    Land use conversion from cropland to natural vegetation can be an effective mechanism to reduce soil C losses and promote soil C recovery affecting the storage of C in soils. Understanding how anthropogenic land use changes lead to implications for soil C storage and how it affects the distribution of total carbon provide information that will support the application of best management practices to restore or maintain soil C. Agricultural abandonment is one of the most important land use changes in recent decades in Mediterranean catchments. This land use change can play a key role on ecosystems functions that, can be particularly relevant in Mediterranean mountain landscapes where soils are fragile and prone to erosion. This research aims to evaluate the effects of land use changes on SOC stocks at catchment scale. To this purpose, a total of 98 soil samples were collected on a 500 m grid in the Barués catchment (23 km2) with elevation ranges between 535 and 964 m.a.s.l and mean slope of 16°. The study area is a Mediterranean mountain ephemeral stream catchment located in the central part of the Ebro Basin in northeast Spain (4699000N 647300E) where in recent decades the abandonment of cultivated areas was the main land use change. The sampling points are distributed proportionally in function of the percentage area occupied by the different land uses to be statistically comparable. The SOC content was measured by dry combustion method with LECO equipment. A soil type map of the catchment and two land use maps were created based on two different scenarios using aerial photography for 1957 and 2010 in order to compare how land use has affected carbon storage in the catchment. Six main soil types were identified named Calcisols, Cambisols, Fluvisols, Leptosols and Regosols. The results show an important decrease (71%) of the cultivated land that in 1957 extended over 13.4 km2 whereas today only occupies 3.8 km2 while forested areas increased from 9.2 km2 in 1957

  19. Association of two polymorphisms within and near SOCS3 gene with obesity in three nationalities in Xinjiang province of China

    Institute of Scientific and Technical Information of China (English)

    Wei TANG; Jun-jie ZOU; Xiang-fang CHEN; Jiao-yang ZHENG; Hua-zong ZENG; Zhi-min LIU; Yong-quan SHI

    2011-01-01

    Aim:SOCS3 gene plays an important role in the pathogenesis of obesity in animal models,but the data from human studies are relatively limited.To address this issue,a genetic association analysis on nationalities with different genetic background living in the similar environmental conditions was performed.Methods:Two thousand seven hundred eleven subjects were randomly recruited from the Kazakh,Uygur and Han nationalities in Xinjiang of China.SNP polymorphisms rs4969168 and rs9892622 within or near the SOCS3 gene were genotyped using TaqMan-MGBTM assay.Association study between the two polymorphisms and obesity-related traits (body mass index [BMI]; waist-to-hip ratio [WHR];weight; height,WAIST,and HIP measurements) was conducted.Results:Significant association was found between rs4969168 and the obesity-related traits,including BMI (25.32+3.49 kg/m2 for AA,24.60+3.70 kg/m2 for AG,24.39+3.42 kg/m2 for GG,P=0.042),weight (65.58+11.42 kg for AA,63.50+11.30 kg for AG,62.00±10.78 kg for GG,P=0.011) in the Han nationality,but not in the Kazakh or Uygur nationalities.Rs9892622 was significantly associated with BMI,WHR,and WAIST in the Uygur males.Rs9892622 was also associated with BMI in Kazakh males.Linear regression analysis verified the above findings.However,neither of the two polymorphisms was associated with obesity-related traits in the total population.Conclusion:The polymorphism rs4969168 within or near the SOCS3 gene has a significant effect in the Han nationality,while rs9892622 was associated with obesity in Uygur and Kazakh nationalities in Xinjiang of China.

  20. A mixed SOC-turbulence model for nonlocal transport and space-fractional Fokker-Planck equation

    CERN Document Server

    Milovanov, Alexander V

    2013-01-01

    The phenomena of nonlocal transport in magnetically confined plasma are theoretically analyzed. A hybrid model is proposed, which brings together the notion of inverse energy cascade, typical of drift-wave- and two-dimensional fluid turbulence, and the ideas of avalanching behavior, associable with self-organized critical (SOC) behavior. Using statistical arguments, it is shown that an amplification mechanism is needed to introduce nonlocality into dynamics. We obtain a consistent derivation of nonlocal Fokker-Planck equation with space-fractional derivatives from a stochastic Markovian process with the transition probabilities defined in reciprocal space.

  1. Wrapper/TAM Co-Optimization and Test Scheduling for SOCs Using Rectangle Bin Packing Considering Diagonal Length of Rectangles

    CERN Document Server

    Islam, Md Rafiqul; Mahmud, Abdullah Al; Islam, Md Saiful; Babu, Hafiz Md Hasan

    2010-01-01

    This paper describes an integrated framework for SOC test automation. This framework is based on a new approach for Wrapper/TAM co-optimization based on rectangle packing considering the diagonal length of the rectangles to emphasize on both TAM widths required by a core and its corresponding testing time. In this paper, we propose an efficient algorithm to construct wrappers that reduce testing time for cores. We then use rectangle packing to develop an integrated scheduling algorithm that incorporates power constraints in the test schedule. The test power consumption is important to consider since exceeding the system's power limit might damage the system.

  2. Comment on "Wave model of the cat tympanic membrane" [J. Acoust. Soc. Am. 122(2), 918-931 (2007)].

    Science.gov (United States)

    Serwy, Roger D

    2014-05-01

    The tympanic membrane model as developed by Parent and Allen [(2007). J. Acoust. Soc. Am. 122(2), 918-931] is shown to have active, lossy, and non-reciprocal properties despite being described as lossless. These properties are traced back to its scattering junction formulations. Some impedance parameters are shown to have ambiguous values which complicate interpreting the physics of the model's internal wave propagation. Certain model parameters omitted from the original paper have been derived from the original computer simulation source code used by Parent and Allen.

  3. 集成SOC芯片系统的关键技术%The Crucial Technology of Integrated SOC System Chip

    Institute of Scientific and Technical Information of China (English)

    侯朝焕

    2004-01-01

    集成SOC芯片系统是21世纪的发展方向.它是微电子技术按摩尔定律发展的必然结果.但为了实现SOC,还需要克服一系列设计和工艺上的难关.我国国家自然科学基金委和科技部对SOC发展已作了部署,可望我国在SOC芯片上取得快速发展.

  4. AT-RvD1 Modulates CCL-2 and CXCL-8 Production and NF-κB, STAT-6, SOCS1, and SOCS3 Expression on Bronchial Epithelial Cells Stimulated with IL-4

    Directory of Open Access Journals (Sweden)

    Jhony Robison de Oliveira

    2015-01-01

    Full Text Available Bronchial epithelial cells represent the first line of defense against microorganisms and allergens in the airways and play an important role in chronic inflammatory processes such as asthma. In an experimental model, both RvD1 and AT-RvD1, lipid mediators of inflammation resolution, ameliorated some of the most important phenotypes of experimental asthma. Here, we extend these results and demonstrate the effect of AT-RvD1 on bronchial epithelial cells (BEAS-2B stimulated with IL-4. AT-RvD1 (100 nM decreased both CCL2 and CXCL-8 production, in part by decreasing STAT6 and NF-κB pathways. Furthermore, the effects of AT-RvD1 were ALX/FRP2 receptor dependent, as the antagonist of this receptor (BOC1 reversed the inhibition of these chemokines by AT-RvD1. In addition, AT-RvD1 decreased SOCS1 and increased SOCS3 expression, which play important roles in Th1 and Th17 modulation, respectively. In conclusion, AT-RvD1 demonstrated significant effects on the IL-4-induced activation of bronchial epithelial cells and consequently the potential to modulate neutrophilic and eosinophilic airway inflammation in asthma. Taken together, these findings identify AT-RvD1 as a potential proresolving therapeutic agent for allergic responses in the airways.

  5. 基于 SPEA-II 算法的 SoC 测试多目标优化研究%Optimization of SoC test multiple objects based on SPEA-II agorithm

    Institute of Scientific and Technical Information of China (English)

    谈恩民; 朱峰; 尚玉玲

    2015-01-01

    测试功耗、测试时间是SoC测试优化中的两个测试目标,它们之间存在相互影响的关系。在多目标优化过程中,进化算法对于解决多目标优化问题拥有比较好的优化效果,因此各种进化算法被广泛地应用于SoC测试多目标优化的研究中。对SoC测试时间、测试功耗这两个测试目标建立联合优化模型,分析了NSGA‐II算法与SPEA‐II算法的特点,并对改进型强度Pareto进化算法(SPEA‐Ⅱ)进行研究,进而将SPEA‐II算法用于上述所建立模型的求解。使用ITC’02标准电路中p93791电路和d695电路对上述方法进行实验验证,实验数据表明上述方法可以求得该联合优化模型的一组最优解;并且针对p93791电路,在与NSGA‐II算法的实验数据比较中,得到了更好的优化结果。证明了SPEA‐II算法对SoC测试结构优化方面具有良好的适用性和可行性。%In the system chip SoC test optimization ,test power and test time are the two test target ,they exist interaction relations .In the process of multi‐objective optimization ,evolutionary algorithm for solving multi‐objective optimization problem has good effect ,so various evolutionary algorithms are widely used in SoC test in the study of multi‐objective op‐timization .In the absence of SoC test time or test pow er consumption as the constraint conditions under the premise of the SoC test time and test power joint optimization model of the these two goals .And the improved Strength Pareto Evo‐lutionary Algorithm (SPEA‐II) is studied ,which will SPEA‐II Algorithm used for the solution of the model established . Use the ITC’02 standard p93791 circuit and d695 in the circuit of the above methods to experimental verification ,the re‐sults show that the method can equilibrium solution is provided for the established joint optimization model .And in view of the p93791 circuit ,in the experimental data with the NSGA

  6. Detecting small-scale spatial heterogeneity and temporal dynamics of soil organic carbon (SOC) stocks: a comparison between automatic chamber-derived C budgets and repeated soil inventories

    Science.gov (United States)

    Hoffmann, Mathias; Jurisch, Nicole; Garcia Alba, Juana; Albiac Borraz, Elisa; Schmidt, Marten; Huth, Vytas; Rogasik, Helmut; Rieckh, Helene; Verch, Gernot; Sommer, Michael; Augustin, Jürgen

    2017-03-01

    Carbon (C) sequestration in soils plays a key role in the global C cycle. It is therefore crucial to adequately monitor dynamics in soil organic carbon (ΔSOC) stocks when aiming to reveal underlying processes and potential drivers. However, small-scale spatial (10-30 m) and temporal changes in SOC stocks, particularly pronounced in arable lands, are hard to assess. The main reasons for this are limitations of the well-established methods. On the one hand, repeated soil inventories, often used in long-term field trials, reveal spatial patterns and trends in ΔSOC but require a longer observation period and a sufficient number of repetitions. On the other hand, eddy covariance measurements of C fluxes towards a complete C budget of the soil-plant-atmosphere system may help to obtain temporal ΔSOC patterns but lack small-scale spatial resolution. To overcome these limitations, this study presents a reliable method to detect both short-term temporal dynamics as well as small-scale spatial differences of ΔSOC using measurements of the net ecosystem carbon balance (NECB) as a proxy. To estimate the NECB, a combination of automatic chamber (AC) measurements of CO2 exchange and empirically modeled aboveground biomass development (NPPshoot) were used. To verify our method, results were compared with ΔSOC observed by soil resampling. Soil resampling and AC measurements were performed from 2010 to 2014 at a colluvial depression located in the hummocky ground moraine landscape of northeastern Germany. The measurement site is characterized by a variable groundwater level (GWL) and pronounced small-scale spatial heterogeneity regarding SOC and nitrogen (Nt) stocks. Tendencies and magnitude of ΔSOC values derived by AC measurements and repeated soil inventories corresponded well. The period of maximum plant growth was identified as being most important for the development of spatial differences in annual ΔSOC. Hence, we were able to confirm that AC-based C budgets are able

  7. Suppressor of Cytokine Signaling-3 (SOCS-3) Induces Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) Expression in Hepatic HepG2 Cell Line*

    Science.gov (United States)

    Ruscica, Massimiliano; Ricci, Chiara; Macchi, Chiara; Magni, Paolo; Cristofani, Riccardo; Liu, Jingwen; Corsini, Alberto; Ferri, Nicola

    2016-01-01

    The suppressor of cytokine signaling (SOCS) proteins are negative regulators of the JAK/STAT pathway activated by proinflammatory cytokines, including the tumor necrosis factor-α (TNF-α). SOCS3 is also implicated in hypertriglyceridemia associated to insulin resistance. Proprotein convertase subtilisin kexin type 9 (PCSK9) levels are frequently found to be positively correlated to insulin resistance and plasma very low density lipoprotein (VLDL) triglycerides concentrations. The present study aimed to investigate the possible role of TNF-α and JAK/STAT pathway on de novo lipogenesis and PCSK9 expression in HepG2 cells. TNF-α induced both SOCS3 and PCSK9 in a concentration-dependent manner. This effect was inhibited by transfection with siRNA anti-STAT3, suggesting the involvement of the JAK/STAT pathway. Retroviral overexpression of SOCS3 in HepG2 cells (HepG2SOCS3) strongly inhibited STAT3 phosphorylation and induced PCSK9 mRNA and protein, with no effect on its promoter activity and mRNA stability. Consistently, siRNA anti-SOCS3 reduced PCSK9 mRNA levels, whereas an opposite effect was observed with siRNA anti-STAT3. In addition, HepG2SOCS3 express higher mRNA levels of key enzymes involved in the de novo lipogenesis, such as fattyacid synthase, stearoyl-CoA desaturase (SCD)-1, and apoB. These responses were associated with a significant increase of SCD-1 protein, activation of sterol regulatory element-binding protein-1c (SREBP-1), accumulation of cellular triglycerides, and secretion of apoB. HepG2SOCS3 show lower phosphorylation levels of insulin receptor substrate 1 (IRS-1) Tyr896 and Akt Ser473 in response to insulin. Finally, insulin stimulation produced an additive effect with SOCS3 overexpression, further inducing PCSK9, SREBP-1, fatty acid synthase, and apoB mRNA. In conclusion, our data candidate PCSK9 as a gene involved in lipid metabolism regulated by proinflammatory cytokine TNF-α in a SOCS3-dependent manner. PMID:26668321

  8. A Fully Integrated Sensor SoC with Digital Calibration Hardware and Wireless Transceiver at 2.4 GHz

    Directory of Open Access Journals (Sweden)

    Dong-Sun Kim

    2013-05-01

    Full Text Available A single-chip sensor system-on-a-chip (SoC that implements radio for 2.4 GHz, complete digital baseband physical layer (PHY, 10-bit sigma-delta analog-to-digital converter and dedicated sensor calibration hardware for industrial sensing systems has been proposed and integrated in a 0.18-μm CMOS technology. The transceiver’s building block includes a low-noise amplifier, mixer, channel filter, receiver signal-strength indicator, frequency synthesizer, voltage-controlled oscillator, and power amplifier. In addition, the digital building block consists of offset quadrature phase-shift keying (OQPSK modulation, demodulation, carrier frequency offset compensation, auto-gain control, digital MAC function, sensor calibration hardware and embedded 8-bit microcontroller. The digital MAC function supports cyclic redundancy check (CRC, inter-symbol timing check, MAC frame control, and automatic retransmission. The embedded sensor signal processing block consists of calibration coefficient calculator, sensing data calibration mapper and sigma-delta analog-to-digital converter with digital decimation filter. The sensitivity of the overall receiver and the error vector magnitude (EVM of the overall transmitter are −99 dBm and 18.14%, respectively. The proposed calibration scheme has a reduction of errors by about 45.4% compared with the improved progressive polynomial calibration (PPC method and the maximum current consumption of the SoC is 16 mA.

  9. Inflammation and linear bone growth: the inhibitory role of SOCS2 on GH/IGF-1 signaling.

    Science.gov (United States)

    Farquharson, Colin; Ahmed, S Faisal

    2013-04-01

    Linear bone growth is widely recognized to be adversely affected in children with chronic kidney disease (CKD) and other chronic inflammatory disorders. The growth hormone (GH)/insulin-like growth factor-1 (IGF-1) pathway is anabolic to the skeleton and inflammatory cytokines compromise bone growth through a number of different mechanisms, which include interference with the systemic as well as the tissue-level GH/IGF-1 axis. Despite attempts to promote growth and control disease, there are an increasing number of reports of the persistence of poor growth in a substantial proportion of patients receiving rhGH and/or drugs that block cytokine action. Thus, there is an urgent need to consider better and alternative forms of therapy that are directed specifically at the mechanism of the insult which leads to abnormal bone health. Suppressor of cytokine signaling 2 (SOCS2) expression is increased in inflammatory conditions including CKD, and is a recognized inhibitor of GH signaling. Therefore, in this review, we will focus on the premise that SOCS2 signaling represents a critical pathway in growth plate chondrocytes through which pro-inflammatory cytokines alter both GH/IGF-1 signaling and cellular function.

  10. Development of a SoC for Digital Television Set-Top Box: Architecture and System Integration Issues

    Directory of Open Access Journals (Sweden)

    André Borin Soares

    2013-01-01

    Full Text Available This work presents the integration of several IPs to generate a system-on-chip (SoC for digital television set-top box compliant to the SBTVD standard. Embedded consumer electronics for multimedia applications like video processing systems require large storage capacity and high bandwidth memory. Also, those systems are built from heterogeneous processing units, designed to perform specific tasks in order to maximize the overall system efficiency. A single off-chip memory is generally shared between the processing units to reduce power and save costs. The external memory access is one bottleneck when decoding high-definition video sequences in real time. In this work, a four-level memory hierarchy was designed to manage the decoded video in macroblock granularity with low latency. The use of the memory hierarchy in the system design is challenging because it impacts the system integration process and IP reuse in a collaborative design team. Practical strategies used to solve integration problems are discussed in this text. The SoC architecture was validated and is being progressively prototyped using a Xilinx Virtex-5 FPGA board.

  11. Hepatitis B virus X protein impairs hepatic insulin signaling through degradation of IRS1 and induction of SOCS3.

    Directory of Open Access Journals (Sweden)

    KyeongJin Kim

    Full Text Available BACKGROUND: Hepatitis B virus (HBV is a major cause of chronic liver diseases, and frequently results in hepatitis, cirrhosis, and ultimately hepatocellular carcinoma. The role of HCV in associations with insulin signaling has been elucidated. However, the pathogenesis of HBV-associated insulin signaling remains to be clearly characterized. Therefore, we have attempted to determine the mechanisms underlying the HBV-associated impairment of insulin signaling. METHODOLOGY: The expressions of insulin signaling components were investigated in HBx-transgenic mice, HBx-constitutive expressing cells, and transiently HBx-transfected cells. Protein and gene expression was examined by Western blot, immunohistochemistry, RT-PCR, and promoter assay. Protein-protein interaction was detected by coimmunoprecipitation. PRINCIPAL FINDINGS: HBx induced a reduction in the expression of IRS1, and a potent proteasomal inhibitor blocked the downregulation of IRS1. Additionally, HBx enhanced the expression of SOCS3 and induced IRS1 ubiquitination. Also, C/EBPalpha and STAT3 were involved in the HBx-induced expression of SOCS3. HBx interfered with insulin signaling activation and recovered the insulin-mediated downregulation of gluconeogenic genes. CONCLUSIONS/SIGNIFICANCE: These results provide direct experimental evidences for the contribution of HBx in the impairment of insulin signaling.

  12. Development of control system for multi-converter High voltage Power supply using programmable SoC

    Science.gov (United States)

    Dave, Rasesh; Dharangutti, Jagruti; Singh, N. P.; Thakar, Aruna; Dhola, Hitesh; Gajjar, Sandip; Parmar, Darshan; Zaveri, Tanish; Baruah, Ujjwal

    2017-04-01

    Multi-converter based High Voltage Power Supplies (HVPSs) find application in multi-megawatt accelerators, RF systems. Control system for HVPS must be a combination of superior parallel processing, real time performance, fast computation and versatile connectivity. The hardware platform is expected to be robust, easily scalable for future developments with minimal overheads. This paper describes development of control system on Zynq All Programmable SoC (System on Chip) for HVPS. Typical HVPS control mechanism involves communication, generation of precise control signals/pulses for few hundred numbers of chopper and closed loop control in microsecond range for regulated output. Such kind of requirements can be met with Zynq All Programmable SoC, which is a combination of Dual core ARM Cortex A-9 Processing System (PS) and Xilinx 7 series FPGA based Programmable Logic (PL). Deterministic functions of power supply control system such as generation of control signals with precise inter-channel delay of nanosecond range and communication with individual chopper at 100kbps can be implemented on PL. PS should implement corrective tasks based on field feedback received from individual chopper, user interface and OS management that allows to take full advantage of system capabilities. PS and PL are connected with on-chip AXI-4 interface with low latency and higher bandwidth through 9 AXI ports. Typically PS boots first, this ensures secure booting and prevents external environment from tampering PL.

  13. Hybridizing grey wolf optimization with differential evolution for global optimization and test scheduling for 3D stacked SoC

    Institute of Scientific and Technical Information of China (English)

    Aijun Zhu; Chuanpei Xu; Zhi Li; Jun Wu; Zhenbing Liu

    2015-01-01

    A new meta-heuristic method is proposed to enhance current meta-heuristic methods for global optimization and test scheduling for three-dimensional (3D) stacked system-on-chip (SoC) by hybridizing grey wolf optimization with differential evo-lution (HGWO). Because basic grey wolf optimization (GWO) is easy to fal into stagnation when it carries out the operation of at-tacking prey, and differential evolution (DE) is integrated into GWO to update the previous best position of grey wolf Alpha, Beta and Delta, in order to force GWO to jump out of the stagnation with DE’s strong searching ability. The proposed algorithm can accele-rate the convergence speed of GWO and improve its performance. Twenty-three wel-known benchmark functions and an NP hard problem of test scheduling for 3D SoC are employed to verify the performance of the proposed algorithm. Experimental results show the superior performance of the proposed algorithm for exploiting the optimum and it has advantages in terms of exploration.

  14. A fully integrated sensor SoC with digital calibration hardware and wireless transceiver at 2.4 GHz.

    Science.gov (United States)

    Kim, Dong-Sun; Jang, Sung-Joon; Hwang, Tae-Ho

    2013-05-21

    A single-chip sensor system-on-a-chip (SoC) that implements radio for 2.4 GHz, complete digital baseband physical layer (PHY), 10-bit sigma-delta analog-to-digital converter and dedicated sensor calibration hardware for industrial sensing systems has been proposed and integrated in a 0.18-μm CMOS technology. The transceiver's building block includes a low-noise amplifier, mixer, channel filter, receiver signal-strength indicator, frequency synthesizer, voltage-controlled oscillator, and power amplifier. In addition, the digital building block consists of offset quadrature phase-shift keying (OQPSK) modulation, demodulation, carrier frequency offset compensation, auto-gain control, digital MAC function, sensor calibration hardware and embedded 8-bit microcontroller. The digital MAC function supports cyclic redundancy check (CRC), inter-symbol timing check, MAC frame control, and automatic retransmission. The embedded sensor signal processing block consists of calibration coefficient calculator, sensing data calibration mapper and sigma-delta analog-to-digital converter with digital decimation filter. The sensitivity of the overall receiver and the error vector magnitude (EVM) of the overall transmitter are -99 dBm and 18.14%, respectively. The proposed calibration scheme has a reduction of errors by about 45.4% compared with the improved progressive polynomial calibration (PPC) method and the maximum current consumption of the SoC is 16 mA.

  15. Neighborhood-resources for the development of a strong SOC and the importance of understanding why and how resources work: a grounded theory approach.

    Science.gov (United States)

    Maass, Ruca; Lindström, Bengt; Lillefjell, Monica

    2017-09-12

    Providing individuals with psychosocial resources such as sense of coherence (SOC) seems a beneficial strategy for health promotion in the neighborhood. In order to become a supporting theory for health promotion, Salutogenesis should renew its focus on resources for health, and explore how the development of a strong SOC can be facilitated. Relevant issues were explored using a Grounded Theory- approach. Three focus-group-sessions and three in-depth interviews were conducted with strategically sampled participants. The transcripts of the focus groups were initially analyzed line-by-line to ensure that insights emerged from the data. We then applied focused and systemic analyses to achieve axial coding, and to include insights into how social interactions during focus groups may reveal social processes in real-life-neighborhoods. The data from the in-depth interviews were used to validate and fill emerging categories, as well as to ensure data-saturation. Findings indicate the importance of repeated experiences with resources and every-day-challenges to develop a strong SOC. Active engagement with resources is a favorable condition for significant experiences, which enhance the internalization of resources. Core experiences are characterized by a re-organization of resources. Participation in intellectual meaning-making through equal power dialogue seems to broaden perspectives and promote the strengthening of SOC. A strong SOC can also be described as a deeper understanding of how and why resources work, which allows for a more flexible use of resources, including replacing missing resources. A new understanding of SOC as an intuitive understanding of how, why and under which circumstances resources work, as well as a new focus on everyday life and repeated experiences might facilitate new approaches to a purposeful strengthening of SOC through the planning and implementation of public measures.

  16. [Structural analysis for psychosocial factors including health locus of control (HLC) and sense of coherence (SOC) associated with lifestyle-related diseases].

    Science.gov (United States)

    Ogawa, Y; Nakamura, H; Nagase, H; Ogino, K; Ooshita, Y; Tsukahara, S

    2001-01-01

    The purpose of this study was to clarify psychosocial characteristics associated with preventive health behavior for lifestyle-related diseases. The author performed objective health examinations and gave questionnaires to 289 men (39.7 +/- 11.8 years, mean +/- SD) and 80 women (32.8 +/- 10.4 years) engaged in office work. Psychosocial factors included lifestyle and perceived stress, as well as the health locus of control (HLC) and sense of coherence (SOC) as newly developed indicators for health behavior. The principal component analysis for men did not extract lifestyle from the psychosocial structures. Multiple regression analysis showed that internal HLC (IHLC), chance HLC (CHLC), professional HLC (PHLC) and stress significantly contributed to SOC. Principal component analysis using psychosocial factors in women showed two psychosocial structures, i.e. the second principal (high SOC, high lifestyle, and low stress) and the 4th principal components (high supernatural HLC, and high PHLC). Both components were negatively correlated with systolic blood pressure. SOC was recognized to be negatively associated with age, stress, and total cholesterol, and positively with IHLC, FHLC, lifestyle, and gamma-GTP using multiple regression analysis for women. These results indicated a distinguishable sex difference regarding the involvement of psychosocial factors including HLC and SOC in objective health. SOC seems likely to be involved not in objective health, but closely with stress, suggesting a direct influence on mental health. Lifestyle should be divided into more detailed categories such as smoking and salt intake. Structural analysis of women suggests that SOC is involved directly or indirectly through lifestyle in objective health, different from men. To further clarify causal relationships between psychosocial factors and risk factors for lifestyle-related diseases, a longitudinal study is necessary based on these results.

  17. socs7, a target gene of microRNA-145, regulates interferon-β induction through STAT3 nuclear translocation in bladder cancer cells.

    Science.gov (United States)

    Noguchi, S; Yamada, N; Kumazaki, M; Yasui, Y; Iwasaki, J; Naito, S; Akao, Y

    2013-02-07

    We recently reported that microRNA (miR)-145 is downregulated and induces apoptosis in human bladder cancer cells. Also, it is suggested that the ectopic expression of miR-145 induces apoptosis with the induction of TRAIL expression in several cancer cells. Here, we demonstrated a novel mechanism of apoptosis induction by miR-145 in bladder cancer cells. Exogenous miR-145 in T24 and NKB1 cells markedly increased the expression levels of interferon (IFN)-β, 2'-5'-oligoadenylate synthetase 1, which lies upstream of 2'-5' oligoadenylates/RNase L system, and TRAIL, and induced apparent caspase-dependent apoptosis that was suppressed by cotreatment with a pan-caspase inhibitor; moreover, these expression levels were reduced by cotreatment with an miR-145 inhibitor. The apoptosis did not depend on Toll-like receptor 3 (TLR3) expression, because TLR3-silencing failed to inhibit IFN-β induction by miR-145. Then, we focused on the suppressor of cytokine signaling 7 (socs7), whose expression level was upregulated in bladder cancer cells compared with its level in normal human urothelial cells, as a putative target gene involved in IFN-β induction by miR-145. Expectedly, exogenous miR-145 decreased the expression level of SOCS7, and socs7-silencing enhanced IFN-β induction by transfection with a TLR3 ligand, polyinosinic acid-polycytidylic acid (PIC). The results of a luciferase reporter assay revealed that miR-145 targeted socs7. In addition, socs7-silencing significantly decreased the level of p-Akt and suppressed the growth of T24 cells. Furthermore, exogenous miR-145 or socs7-silencing promoted nuclear translocation of STAT3. In conclusion, the machinery of IFN-β induction through the regulation of SOCS7 by miR-145 was closely associated with the induction of apoptosis. Moreover, exogenous miR-145 promoted IFN-β induction by targeting socs7, which resulted in the nuclear translocation of STAT3. Additionally, our data indicate that SOCS7 functioned as an oncogene

  18. The potential role of SOCS-3 in the interleukin-1beta-induced desensitization of insulin signaling in pancreatic beta-cells

    DEFF Research Database (Denmark)

    Emanuelli, Brice; Glondu, Murielle; Filloux, Chantal

    2004-01-01

    insulin-dependent IR autophosphorylation and IRS/PI3K pathway in a way comparable to IL-1beta treatment in RINm5F cells. We propose that IL-1beta decreases insulin action in beta-cells through the induction of SOCS-3 expression, and that this effect potentially alters insulin-induced beta-cell survival.......) proteins as well as phosphatidylinositol 3-kinase (PI3K) activation, and that this action is not due to the IL-1beta-dependent nitric oxide (NO) production in RINm5F cells. We next analyzed if suppressor of cytokine signaling (SOCS)-3, which can be induced by multiple cytokines and which we identified...... as an insulin action inhibitor, was implicated in the IL-1beta inhibitory effect on insulin signaling in these cells. We show that IL-1beta increases SOCS-3 expression and induces SOCS-3/IR complex formation in RINm5F cells. Moreover, we find that ectopically expressed SOCS-3 associates with the IR and reduces...

  19. Upscaling SOC changes from long term field experiments to regional level - evaluation of agri-environmental measures on their contribution to mitigate climate change

    Science.gov (United States)

    Freudenschuss, Alexandra; Sedy, Katrin; Spiegel, Heide; Zethner, Gerhard

    2010-05-01

    Several agri-environment measures in Austria are presumed to also mitigate climate change. These are mainly measures that lead to an increase or stabilization of soil organic carbon (SOC) in arable soils, like e.g. organic farming, legumes and cover crops in the crop rotation as well as the application of organic fertilizers. A reduction of mineral fertiliser application may also reduce greenhouse gas emissions. The results of the study aim to evaluate different agricultural practices on their impact on SOC changes. Data from long term field experiments in Austria with different tillage systems and incorporation rates of crop residues and manure are used to determine effects of agricultural practices on SOC changes. Management factors that compare results from different activities on cropland are calculated and compared with international data. Furthermore these data are used to verify results gained from the application of humus balance model (VDLUFA). For the upscaling of potential SOC changes at regional level (federal states of Austria) data of the IACS - Integrated Administrative Control System are applied in the humus balance model. In order to cover the range of possible SOC changes three different approaches of the humus balance model are introduced and the results will be presented.

  20. Pain Control on Demand Based on Pulsed Radio-Frequency Stimulation of the Dorsal Root Ganglion Using a Batteryless Implantable CMOS SoC.

    Science.gov (United States)

    Hung-Wei Chiu; Mu-Lien Lin; Chii-Wann Lin; I-Hsiu Ho; Wei-Tso Lin; Po-Hsiang Fang; Yi-Chin Lee; Yeong-Ray Wen; Shey-Shi Lu

    2010-12-01

    This paper presents the implementation of a batteryless CMOS SoC with low voltage pulsed radio-frequency (PRF) stimulation. This implantable SoC uses 402 MHz command signals following the medical implanted communication system (MICS) standard and a low frequency (1 MHz) for RF power transmission. A body floating type rectifier achieves 84% voltage conversion ratio. A bi-phasic pulse train of 1.4 V and 500 kHz is delivered by a PRF driver circuit. The PRF parameters include pulse duration, pulse frequency and repetition rate, which are controllable via 402 MHz RF receiver. The minimal required 3 V RF Vin and 2.2 V VDDr is achieved at 18 mm gap. The SoC chip is fabricated in a 0.35 μm CMOS process and mounted on a PCB with a flexible spiral antenna. The packaged PRF SoC was implanted into rats for the animal study. Von Frey was applied to test the mechanical allodynia in a blinded manner. This work has successfully demonstrated that implanted CMOS SoC stimulating DRG with 1.4 V, 500 kHz PRF could significantly reduce spinal nerve ligation (SNL) induced mechanical allodynia for 3-7 days.

  1. SOCS3和Pyk2在非小细胞肺癌中的表达及相关性研究%Expression of SOCS3 and Pyk2 and their correlation in non-small cell lung cancer

    Institute of Scientific and Technical Information of China (English)

    张四洋; 邱雪杉

    2012-01-01

    目的 探讨SOCS3和Pyk2在非小细胞肺癌(NSCLC)中的表达及其相互作用.方法 分别采用免疫组织化学和免疫荧光染色方法检测SOCS3和Pyk2在100例NSCLC组织、人支气管上皮细胞HBE和6个NSCLC细胞系中的表达.采用甲基化特异性PCR方法检测A549细胞中SOCS3基因甲基化状态.A549细胞经蛋白酶体抑制剂β-lactacystin预处理,再加入去甲基化试剂5-aza-2 ’-脱氧胞苷(5-aza),或转染SOCS3突变质粒,检测Pyk2蛋白、Pyk2 Tyr402和ERK1/2磷酸化水平.采用逆转录(RT)-PCR检测Pyk2 mRNA水平.采用Transwell小室测定细胞迁移情况.结果 100例NSCLC组织中,43例(43.0%) SOCS3阳性表达,65例(65.0%) Pyk2高表达.在NSCLC组织和细胞系中均发现SOCS3和Pyk2表达负相关.5-aza能恢复A549细胞中SOCS3的表达.SOCS3依赖于其SH2和KIR功能区与Pyk2相互作用,从而降低Pyk2蛋白、Pyk2 Tyr402和ERK1/2磷酸化水平,抑制A549细胞迁移.结论 NSCLC中,SOCS3可能通过SOCS-box功能区介导的蛋白酶体途径促使Pyk2蛋白降解,阻断A549细胞迁移.%Objective To investigate the expression of SOCS3 and Pyk2 and their correlations in non-small cell lung cancer (NSCLC).Methods The expression of SOCS3 and Pyk2 was detected in 100 cases of NSCLC,human bronchial epithelial cells (HBE) and 6 lung cancer cell lines by immunohistochemistry and immunofluorescence staining.The methylation status of SOCS3 was investigated in A549 cells by methylation-specific PCR.A549 cells were either treated with a demethylation agent 5-aza-2'-deoxycytidine (5-aza) or transfected with three SOCS3 mutants with various functional domains deleted.Besides,the cells were pretreated with a proteasome inhibitor β-1actacystin where indicated.The effects of SOCS3 on Pyk2 expression,Pyk2 Tyr 402 and ERK1/2 phnsphorylations were assessed by Western blot.RT-PCR was used to estimate Pyk2 mRNA levels.Transwell experiments were performed to evaluate cell migration.Results SOCS3(43.0%,43

  2. SOCS3 Immunohistochemical Expression Seems to Support the 2005 and 2014 International Society of Urological Pathology (ISUP) Modified Gleason Grading System.

    Science.gov (United States)

    Pierconti, Francesco; Martini, Maurizio; Cenci, Tonia; Petrone, Gian Luigi; Ricci, Riccardo; Sacco, Emilio; Bassi, Pier Francesco; Larocca, Luigi Maria

    2017-05-01

    In the 2014, The International Society of Urological Pathology (ISUP) consensus conference update the grading of prostate, last revised in 2005. In this study we evaluate the SOCS3 immunohistochemical protein expression in different Gleason prostatic adenocarcinoma: classical Gleason grade 3, classical Gleason grade 3 upgraded to Gleason grade 4 according to the ISUP modifications and classical and modified Gleason grade 4. The major conclusions were: (i) Cribriform glands should be assigned a Gleason pattern 4, regardless of morphology; (ii) Glomeruloid glands should be assigned a Gleason pattern 4, regardless of morphology; (iii) Grading of mucinous carcinoma of the prostate should be based on its underlying growth pattern rather than all as pattern 4; and (iv) Intraductal carcinoma of the prostate without invasive carcinoma should not assigned Gleason grade and a comment about aggressive carcinoma probably associated should be made. In a recent report we analyzed the methylathion status of cytokine signaling (SOCS) proteins 3 (SOCS3) gene and the consequences of promoter hypermethylation on mRNA and protein expression in a collection of prostate cancer and benign prostate hyperplasia (BPH) and for the first time we demonstrated that a hypermethylation of SOCS3 with a significant reduction of its mRNA and protein expression identifies a subgroup of prostate cancer with a more aggressive behavior. Moreover we demonstrated that the immunohystochemical analysis of SOCS3 protein expression in prostatic cancer biopsies may provide a useful and easier method than SOCS3 methylation analysis to individuate in cancer with intermediate-high grade Gleason score a subgroup of prostate cancer with a more aggressive behavior. A total of 148 radical prostatectomy with diagnosis of prostatic acinar adenocarcinoma were stratified into three different categories on the basis of Gleason grade: (i) Twenty-six prostatic adenocarcinoma with classical and modified Gleason grade 3; (ii

  3. Re-Optimization Algorithm for SoC Wrapper-Chain Balance Using Mean-Value Approximation

    Institute of Scientific and Technical Information of China (English)

    NIU Daoheng; WANG Hong; YANG Shiyuan; CHENG Benmao; JIN Yang

    2007-01-01

    Balanced wrapper scan chains are desirable for system-on-chip (SoC) testing because they minimize the time required to transport the test data. A new heuristic algorithm is proposed based on mean-value approximation and implement fast re-optimization as a subsequence of an earlier best-fit-decrease (BFD) method. The mean length of each scan chain was introduced as an approximation target to balance different scan chains and hence saved testing time. Experimental results present both for assumed arbitrary cores and cores from ITC'02 benchmark and show the effectiveness of the algorithm. The proposed algorithm can provide more balanced wrapper design efficiently for the test scheduling stage.

  4. Libero SoC - быстрый старт

    OpenAIRE

    Иоффе, Дмитрий

    2013-01-01

    В статье описаны первые шаги в освоении САПР Libero SoC для работы с ПЛИС фирмы Microsemi. Материал предназначен для разработчиков, уже имеющих опыт работы с ПЛИС других производителей.

  5. Sticker-type ECG/PPG concurrent monitoring system hybrid integration of CMOS SoC and organic sensor device.

    Science.gov (United States)

    Lee, Yongsu; Lee, Hyeonwoo; Yoo, Seunghyup; Yoo, Hoi-Jun; Yongsu Lee; Hyeonwoo Lee; Seunghyup Yoo; Hoi-Jun Yoo; Yoo, Seunghyup; Lee, Yongsu; Yoo, Hoi-Jun; Lee, Hyeonwoo

    2016-08-01

    The sticker-type sensor system is proposed targeting ECG/PPG concurrent monitoring for cardiovascular diseases. The stickers are composed of two types: Hub and Sensor-node (SN) sticker. Low-power CMOS SoC for measuring ECG and PPG signal is hybrid integrated with organic light emitting diodes (OLEDs) and organic photo detector (OPD). The sticker has only 2g weight and only consumes 141μW. The optical calibration loop is adopted for maintaining SNR of PPG signal higher than 30dB. The pulse arrival time (PAT) and SpO2 value can be extracted from various body parts and verified comparing with the reference device from 20 people in-vivo experiments.

  6. Community Readiness Within Systems of Care: The Validity and Reliability of the System of Care Readiness and Implementation Measurement Scale (SOC-RIMS).

    Science.gov (United States)

    Rosas, Scott R; Behar, Lenore B; Hydaker, William M

    2016-01-01

    Establishing a system of care requires communities to identify ways to successfully implement strategies and support positive outcomes for children and their families. Such community transformation is complex and communities vary in terms of their readiness for implementing sustainable community interventions. Assessing community readiness and guiding implementation, specifically for the funded communities implementing a system of care, requires a well-designed tool with sound psychometric properties. This scale development study used the results of a previously published concept mapping study to create, administer, and assess the psychometric characteristics of the System of Care Readiness and Implementation Measurement Scale (SOC-RIMS). The results indicate the SOC-RIMS possesses excellent internal consistency characteristics, measures clearly discernible dimensions of community readiness, and demonstrates the target constructs exist within a broad network of content. The SOC-RIMS can be a useful part of a comprehensive assessment in communities where system of care practices, principles, and philosophies are implemented and evaluated.

  7. Quantification of SOC and Clay Content Using Visible Near-Infrared Reflectance–Mid-Infrared Reflectance Spectroscopy With Jack-Knifing Partial Least Squares Regression

    DEFF Research Database (Denmark)

    Peng, Yi; Knadel, Maria; Gislum, René;

    2014-01-01

    A total of 125 soil samples were collected from a Danish field varying in soil texture from sandy to loamy. Visible near-infrared reflectance (Vis-NIR) and mid-infrared reflectance (MIR) spectroscopy combined with chemometric methods were used to predict soil organic carbon (SOC) and clay contents....... The main objective of this study was to find the best model for predicting SOC and clay content in the sampled field using Vis-NIR, MIR, and the combination of Vis-NIR and MIR and using different model development techniques. The secondary objectives were (i) to use iterations of calculation to find...... the optimal number of replicates for MIR measurements based on the root mean square error of cross validation (RMSECV) and (ii) to apply partial least squares regression in combination with jackknifing (JK) to identify the most important part of spectral variables and the best model for predicting SOC...

  8. Role of SOCS3 in the Jak/stat3 pathway in the human placenta: different mechanisms for preterm and term labor.

    Science.gov (United States)

    Zhou, Xin; Jiang, Ziyan; Zou, Yanfen; Yin, Yin; Zuo, Qing; Sun, Lizhou

    2015-10-01

    To identify changes in interleukin (IL)-6 levels and its pathway (Jak/stat3) in the human placenta during preterm and term labor, placental tissues were collected from primiparous women who underwent vaginal deliveries or cesarean sections in our hospital. The women were divided into three groups: preterm labor (n = 15), term labor (n = 15), and term not in labor (n = 15). IL-6 levels were detected by ELISA in placental supernatant, and p-STAT3 and SOCS3 protein was detected by Western blot. TUNEL was used to detect apoptosis in trophoblasts. HTR-8/SVneo cells were cultured after stimulation with IL-6, and we measured p-STAT3, SOCS3, and the rate of apoptosis. Expression of p-STAT3 and SOCS3 in the placenta and trophoblast cells showed that IL-6 levels were highest in the preterm labor group and lowest in the term not in labor group. The highest expression of placental SOCS3 protein was observed in the preterm labor group. More apoptotic cells were found in the preterm labor group than in the other two groups by TUNEL. SOCS3 and p-STAT3 expression was significantly upregulated after stimulation by IL-6 in trophoblast cells in a dose-dependent manner. However, p-STAT3 was significantly decreased after 50 ng/mL and 100 ng/mL IL-6 for 72 h. A significant increase of apoptosis was observed with treatment of 50 ng/mL IL-6 in HTR-8/SVneo cells. The role of the SOCS3 protein in the Jak/stat3 pathway is to mediate different mechanisms for preterm and term labor processes in the placenta. © 2015 Nordic Federation of Societies of Obstetrics and Gynecology.

  9. Nectin-4 Co-stimulates the Prolactin Receptor by Interacting with SOCS1 and Inhibiting Its Activity on the JAK2-STAT5a Signaling Pathway.

    Science.gov (United States)

    Maruoka, Masahiro; Kedashiro, Shin; Ueda, Yuki; Mizutani, Kiyohito; Takai, Yoshimi

    2017-03-03

    Cell surface cytokine receptors are regulated by their cis-interacting stimulatory and inhibitory co-receptors. We previously showed that the immunoglobulin-like cell adhesion molecule nectin-4 cis-interacts with the prolactin receptor through the extracellular region and stimulates prolactin-induced prolactin receptor activation and signaling, resulting in alveolar development in the mouse mammary gland. However, it remains unknown how this interaction stimulates these effects. We show here that the cis-interaction of the extracellular region of nectin-4 with the prolactin receptor was not sufficient for eliciting these effects and that nectin-4's cytoplasmic region was also required for eliciting these effects. The cytoplasmic region of nectin-4 directly interacted with suppressor of cytokine signaling (SOCS) 1, but not SOCS3, JAK2, or STAT5a, and inhibited SOCS1's interaction with JAK2, eventually resulting in the increased phosphorylation of STAT5a. The juxtamembrane region of nectin-4 interacts with the Src homology 2 domain of SOCS1. Both the interactions of nectin-4 with the extracellular region of the prolactin receptor and the interactions of SOCS1 with nectin-4's cytoplasmic region were required for the stimulatory effect of nectin-4 on the prolactin-induced prolactin receptor activation. The third immunoglobulin-like domain of nectin-4 and the second fibronectin type-III domain of the prolactin receptor were involved in this cis-interaction, and both the extracellular and transmembrane regions of nectin-4 and the prolactin receptor were required for this direct interaction. These results indicate that nectin-4 serves as a stimulatory co-receptor for the prolactin receptor by regulating the feedback inhibition of SOCS1 in the JAK2-STAT5a signaling pathway.

  10. 大鼠SOCS3基因重组腺病毒载体的构建及转染血管平滑肌细胞后的表达%Construction of Rat SOCS3 Recombinant Adenovirus Vector and Its Expression in Rat Primary Vascular Smooth Muscle Cells

    Institute of Scientific and Technical Information of China (English)

    向水; 董念国; 刘金平; 史嘉玮; 肖雅琼; 王玉

    2012-01-01

    目的 构建携带大鼠SOCS3基因的重组腺病毒载体并转染大鼠血管平滑肌细胞,评价其转染效果,为血管增殖性疾病转基因治疗的实验研究奠定基础.方法 用BamH Ⅰ和EcoR Ⅰ将目的基因pUC57-Simple-rSOCS3及腺病毒穿梭载体pYr-adshuttle- 4(带GFP标记)行双酶切.回收酶切质粒的目的片段进行连接,产物转化至DH5α感受态.提取质粒酶切鉴定正确后测序.通过LR体外同源重组将rSOCS3表达框构建至pAd/PL-DEST腺病毒表达载体上.将腺病毒线性化后转染HEK293细胞包装腺病毒,PCR鉴定此腺病毒中是否含有rSOCS3基因.放大培养并收集病毒,TCD法测定病毒滴度.将此病毒感染大鼠血管平滑肌细胞,荧光显微镜观察感染效率,real-time PCR及免疫印迹检测SOCS3 mRNA及蛋白表达.结果 rSOCS3腺病毒穿梭质粒酶切鉴定正确,测序与rSOCS3基因库中的序列完全相符.PCR鉴定pAd/PL-DEST腺病毒表达载体成功携带目的基因rSOCS3.TCD法测定的最终滴度为2×1010pfu/mL.荧光显微镜观察此病毒感染血管平滑肌细胞的效率在80%以上,real-time PCR及免疫印迹检测结果显示血管平滑肌细胞中SOCS3 mRNA及蛋白表达明显上调.结论 成功构建携带大鼠SOCS3基因的腺病毒载体,并在血管平滑肌细胞中高表达,为血管增殖性疾病转基因治疗的实验研究奠定了基础,具有一定的应用价值.%Objective To construct the recombinant adenovirus vector carrying rat SOCS3 gene and assess its transfection efficiency in vascular smooth muscle cells(VSMCs). Methods The rat SOCS3 plasmid(pUC57-Simple-rSOCS3)and advenovir-us shuttle plasmid(pYr-adshuttle-4)containing green fluorescent protein(GFP)reporter gene were cleaved by restriction endonu-clease BamW I and EcoR I . The target gene fragments were connected together to generate a recombinant plasmid pYr-ad-shuttle-4-rSOCS3 that was transfected into E. coli DH5a. The plasmid was confirmed to be constructed as

  11. The expression of SOCS1 and TLR4-NFkappaB pathway molecules in neoplastic cells as potential biomarker for the aggressive tumor phenotype in laryngeal carcinoma.

    Directory of Open Access Journals (Sweden)

    Magdalena Bryś

    2010-02-01

    Full Text Available Suppressor of cytokine signaling 1 (SOCS1 is the key regulator of cytokine-mediated innate and adaptive immunity. One of the molecular mechanisms of SOCS1 is connected with inhibition of TLR4-NFkappaB pathway. The relationships among these molecules in laryngeal carcinoma are not exactly known. In this preliminary study we focused on their special activity and role in regulation of development and progression of laryngeal carcinoma. To investigate NFkappaB (p65 subunit nuclear and cytoplasmic expression in 45 tumor samples of advanced laryngeal carcinoma IHC staining was performed. To determine the mRNA expression levels of TLR4, IRAK1, TRAF6 and SOCS1 in isolated neoplasm cells and non-cancerous adjacent mucosa epithelial cells RT-PCR was used. The invasiveness of laryngeal carcinomas was evaluated according to tumor front grading, TFG, which included tumor-related features (cytoplasmic differentiation, nuclear polymorphism, number of mitoses and adjacent stroma-related characteristics of the peripheral edge of tumor infiltration (mode of infiltration, depth of invasion and plasmalymphocytic infiltration. The relationships between pT, pN status, the histological G grade, certain clinicopathological characteristics as well as postoperative observation time and the mRNA expression of the molecules mentioned earlier were investigated. Significant differences of TLR4-NFkappaB pathway molecules and SOCS1 mRNA expression in laryngeal tumor cells and normal adjacent mucosa cells as well as significant interconnections of TLR4, SOCS1 and NFkappaB(p65 in isolated tumor cells were obtained. This preliminary study demonstrated that the expression of SOCS1 and TLR4-NFkappaB pathway molecules had a strong association with the aggressiveness of laryngeal carcinoma. Positive relationships of TRAF6 in tumor margin cells with the histological grade and the mode of tumor invasion as well as the TFG total score were highlighted. Significant positive correlations

  12. Suppressor of cytokine signalling (SOCS)-3 protects beta cells against IL-1beta-mediated toxicity through inhibition of multiple nuclear factor-kappaB-regulated proapoptotic pathways

    DEFF Research Database (Denmark)

    Karlsen, Allan Ertman; Heding, P E; Frobøse, H;

    2004-01-01

    The proinflammatory cytokine IL-1beta induces apoptosis in pancreatic beta cells via pathways dependent on nuclear factor-kappaB (NF-kappaB), mitogen-activated protein kinase, and protein kinase C. We recently showed suppressor of cytokine signalling (SOCS)-3 to be a natural negative feedback...... regulator of IL-1beta- and IFN-gamma-mediated signalling in rat islets and beta cell lines, preventing their deleterious effects. However, the mechanisms underlying SOCS-3 inhibition of IL-1beta signalling and prevention against apoptosis remain unknown....

  13. Metal–organic frameworks to satisfy gas upgrading demands: fine-tuning the soc-MOF platform for the operative removal of H2S

    KAUST Repository

    Belmabkhout, Youssef

    2017-01-06

    A cooperative experimental/modeling strategy was used to unveil the structure/gas separation performance relationship for a series of isostructural metal-organic frameworks (MOFs) with soc-topology (square-octahedral) hosting different extra-framework counter ions (NO3-, Cl- and Br-). In3+-, Fe3+-, Ga3+-and the newly isolated Al(III)-based isostructural soc-MOF were extensively studied and evaluated for the separation-based production of high-quality fuels (i.e., CH4, C3H8 and n-C4H10) and olefins. The structural/chemical fine-tuning of the soc-MOF platform promoted equilibrium-based selectivity toward C2+ (C2H6, C2H4, C3H6 C3H8 and n-C4H10) and conferred the desired chemical stability toward H2S. The noted dual chemical stability and gas/vapor selectivity, which have rarely been reported for equilibrium-based separation agents, are essential for the production of high-purity H-2, CH4 and C2+ fractions in high yields. Interestingly, the evaluated soc-MOF analogues exhibited high selectivity for C2H4, C3H6 and n-C4H10. In particular, the Fe, Ga and Al analogues presented relatively enhanced C2+/CH4 adsorption selectivities. Notably, the Ga and Al analogues were found to be technically preferable because their structural integrities and separation performances were maintained upon exposure to H2S, indicating that these materials are highly tolerant to H2S. Therefore, the Ga-soc-MOF was further examined for the selective adsorption of H2S in the presence of CO2-and CH4-containing streams, such as refinery-off gases (ROG) and natural gas (NG). Grand canonical Monte Carlo (GCMC) simulations based on a specific force field describing the interactions between the guest molecules and the Ga sites supported and confirmed the considerably higher affinity of the Ga-soc-MOF for C2+ (as exemplified by n-C4H10) than for CH4. The careful selection of an appropriate metal for the trinuclear inorganic molecular building block (MBB), i. e., a Ga metal center, imbues the soc

  14. Desarrollo de aplicaciones basadas en Linux Embedded en una arquitectura basada en Cyclone V SoC (System on Chip) de Altera

    OpenAIRE

    2014-01-01

    We attempt to integrate and start up the set of necessary tools to deploy the design cycle of embedded systems based on Embedded Linux on a "Cyclone V SoC" made by Altera. First, we will analyze the available tools for designing the hardware system of the SoCkit development kit, made by Arrow, which has a "Cyclone V SoC" system (based on a "ARM Cortex-A9 MP Core" architecture). When designing the SoCkit board hardware, we will create a new peripheral to integrate it into the hardware syste...

  15. CPU/SoC/MCU CoreSight SoC-400:可配置的调试和追踪解决方案

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    ARM公司针对复杂片上系统(SoC)设计推出高度可配置的调试和追踪解决方案ARM CoreSight SoC-400。随着多核产品的日益普及,ARM CoreSight SoC-400提供了系统解决方案,适合移动电话、平板电脑等应用。

  16. Hard to heal pressure ulcers (stage III-IV): efficacy of injected activated macrophage suspension (AMS) as compared with standard of care (SOC) treatment controlled trial.

    Science.gov (United States)

    Zuloff-Shani, Adi; Adunsky, Abraham; Even-Zahav, Aviva; Semo, Haim; Orenstein, Arie; Tamir, Jeremy; Regev, Eli; Shinar, Eilat; Danon, David

    2010-01-01

    The objective of this study was to compare local injections of AMS with SOC treatments for stage III and IV pressure ulcers in elderly patients. It was designed as historically prospective 2-arms non-parallel open controlled trial, and conducted in a department of geriatric medicine and rehabilitation of a university affiliated tertiary hospital. We studied 100 consecutive elderly patients with a total of 216 stage III or IV pressure ulcers, 66 patients were assigned to the AMS group and had their wounds injected, while 38 patients were assigned to the SOC group. Primary outcome was rate of complete wound closure. Time to complete wound closure and 1-year mortality served as secondary outcomes. Statistical analyses were performed at both patient and wound levels. Percentage of completely closed wounds (wound level and patient level) were significantly better (pAMS, as well as in the subset of diabetic patients (pAMS proved significantly better for the subset of those with leg ulcers and with baseline wounds ≤15 cm(2), compared with SOC. There were no statistically significant differences with regard to time to complete closure or 1-year mortality rates in the two groups. It is concluded that there is a significant difference in favor of stage III and IV wound closure rates by AMS, as compared with SOC treatments.

  17. Architectures, Concepts and Technologies for Service Oriented Computing : Proceedings of the 2nd International Workshop on Architectures, Concepts and Technologies for Service Oriented Computing - ACT4SOC 2008

    NARCIS (Netherlands)

    Sinderen, van Marten

    2008-01-01

    This volume contains the proceedings of the Second International Workshop on Architectures, Concepts and Technologies for Service Oriented Computing (ACT4SOC 2008), held on July 5 in Porto, Portugal, in conjunction with the Third International Conference on Software and Data Technologies (ICSOFT 200

  18. Comment on "An approximate transfer function for the dual-resonance nonlinear filter model of auditory frequency selectivity" [J. Acoust. Soc. Am. 114, 2112-21171 (L)

    NARCIS (Netherlands)

    Duifhuis, H

    This letter concerns the paper "An approximate transfer function for the dual-resonance nonlinear filter model of auditory frequency selectivity" [E. A. Lopez-Poveda, J. Acoust. Soc. Am. 114, 2112-2117 (2003)]. It proposes a correction of the historical framework in which the paper is presented.

  19. Self-Regulation among Youth in Four Western Cultures: Is There an Adolescence-Specific Structure of the Selection-Optimization-Compensation (SOC) Model?

    Science.gov (United States)

    Gestsdottir, Steinunn; Geldhof, G. John; Paus, Tomáš; Freund, Alexandra M.; Adalbjarnardottir, Sigrun; Lerner, Jacqueline V.; Lerner, Richard M.

    2015-01-01

    We address how to conceptualize and measure intentional self-regulation (ISR) among adolescents from four cultures by assessing whether ISR (conceptualized by the SOC model of Selection, Optimization, and Compensation) is represented by three factors (as with adult samples) or as one "adolescence-specific" factor. A total of 4,057 14-…

  20. Comment on “Increase in voice level and speaker comfort in lecture rooms” [J. Acoust. Soc. Am. 125, 2072–2082 (2009)] (L)

    DEFF Research Database (Denmark)

    Pelegrin Garcia, David

    2011-01-01

    Recently, a paper written by Brunskog Gade, Paya´-Ballester and Reig-Calbo, “Increase in voice level and speaker comfort in lecture rooms” [J. Acoust. Soc. Am. 125, 2072–2082 (2009)] related teachers’ variation in vocal intensity during lecturing to the room acoustic conditions, introducing...

  1. Correction: A strongly greenish-blue-emitting Cu4Cl4 cluster with an efficient spin-orbit coupling (SOC): fast phosphorescence versus thermally activated delayed fluorescence.

    Science.gov (United States)

    Chen, Xu-Lin; Yu, Rongmin; Wu, Xiao-Yuan; Liang, Dong; Jia, Ji-Hui; Lu, Can-Zhong

    2016-06-21

    Correction for 'A strongly greenish-blue-emitting Cu4Cl4 cluster with an efficient spin-orbit coupling (SOC): fast phosphorescence versus thermally activated delayed fluorescence' by Xu-Lin Chen et al., Chem. Commun., 2016, 52, 6288-6291.

  2. Nicolás Mascardi e a carta-relación de 1670: uma análise preliminar das observações astronômicas realizadas pelo missionário jesuíta = Nicolás Mascardi and the carta-relación de 1670: a preliminary analysis of astronomical observations carried out by the jesuit missionary

    Directory of Open Access Journals (Sweden)

    Biehl, Maico

    2014-01-01

    Full Text Available O presente artigo apresenta os resultados preliminares da pesquisa que venho desenvolvendo como bolsista PIBIC/CNPq junto ao projeto “Uma ordem de homens de religião e de ciência: difusão, produção e circulação de saberes e práticas científicas pela Companhia de Jesus (América meridional, séculos XVII e XVIII”. O subprojeto prevê o contato com as teorias astronômicas vigentes no Seiscentos e no Setecentos, com as obras de Astronomia que integravam os acervos da Ordem e com os estudos produzidos por missionários já no Novo Mundo. Assim como, a reconstituição das trajetórias de jesuítas que realizaram observações astronômicas nas reduções em que atuaram, compartilhando os seus estudos através da prática epistolar ou por meio de obras. Neste artigo, especificamente, me detenho em reconstituir brevemente a trajetória do jesuíta Nicolas Mascardi, destacando as observações astronômicas que realizou na América e as suas comunicações com demais estudiosos da astronomia.

  3. SOCS3 expression within leptin receptor-expressing cells regulates food intake and leptin sensitivity but does not affect weight gain in pregnant mice consuming a high-fat diet.

    Science.gov (United States)

    Zampieri, Thais Tessari; da Silva, Tiago Eugênio Oliveira; de Paula Romeu, Deborah; Torrão, Andréa da Silva; Donato, Jose

    2016-04-01

    Pregnancy induces transitory metabolic changes including increases in food intake and body fat deposition, as well as leptin and insulin resistance. Recent findings have suggested that increased hypothalamic expression of suppressor of cytokine signaling-3 (SOCS3) is a key mechanism responsible for triggering those metabolic adaptations. Because obesity is a risk factor for gestational metabolic imbalances, we aimed to study the role of SOCS3 during pregnancy in obese mice. Female mice carrying a deletion of SOCS3 in leptin receptor-expressing cells (SOCS3 KO mice) were exposed to a chronic high-fat diet (HFD), and we then studied their energy balance and glucose homeostasis during pregnancy. SOCS3 deletion did not prevent diet-induced obesity or changes in body weight and adiposity observed during pregnancy. However, the typical increase in food intake during mid- and late-pregnancy was blunted in SOCS3 KO females. We also observed a slight improvement in glucose homeostasis and increased leptin sensitivity in the arcuate nucleus of the hypothalamus in pregnant SOCS3 KO mice on HFD. Despite this, SOCS3 KO mice had an increased number of uterine reabsorptions and fewer fetuses compared to the controls. Compared to control animals, a reduction in proopiomelanocortin and an increase in oxytocin mRNA levels were observed in the hypothalamus of pregnant SOCS3 KO mice. In contrast to previous studies using lean animals, conditional SOCS3 ablation did not prevent major gestational metabolic changes in diet-induced obese mice. Our findings contribute to the understanding of the role of SOCS3 in mediating pregnancy-induced metabolic adaptations.

  4. SoC低功耗应用技术研究%Research on SoC Low-Power Application Technology

    Institute of Scientific and Technical Information of China (English)

    吴志祥; 方晓毅; 黄亮

    2015-01-01

    为了提高SoC应用系统的可靠性,增强抗干扰能力,降低电源电路负载功率,或在相同电池容量条件下为了延长SoC应用系统的工作时间,在结合分析当今SoC特点的基础上,对SoC低功耗的基本方法、工作模式及任务特点等开展讨论。通过采取降低工作电压、工作频率、优化程序结构及低功耗模式综合应用等措施,充分发挥SoC低功耗能力。工程实践表明,绝大多数SoC应用系统均可降低到1 mW功耗水平。所涉及之方法,可为普遍意义上SoC应用系统的低功耗设计,提供参考。%In order to improve the reliability of SoC system, enhance the anti-interference ability, reduce the load power of power circuit, or extend working hours of SoC application system under the condition of the same battery capacity, the discussion about the basic method of SoC low power consumption, working mode and task characteristics is presented together with the analysis of the current SoC characteristics. The SoC low consumption ability can be fully utilized by working with lower voltage and frequency, optimized program structure and comprehensive application of low power consumption mode. Engineering practices show that the vast majority of SoC application systems can reduce the power consumption level to one milliwatt. The method involved provides references generally for the design of low power consumption ability of the SoC application system.

  5. Soil Organic Carbon (SOC) distribution in two differents soil types (Podzol and Andosol) under natural forest cover.

    Science.gov (United States)

    Álvarez-Romero, Marta; Papa, Stefania; Verstraeten, Arne; Cools, Nathalie; Lozano-García, Beatriz; Parras-Alcántara, Luis; Coppola, Elio

    2017-04-01

    Andosols are young soils that shall know a successive evolution towards pedological types where the dominant pedogenetic processes are more evident. Vegetation and climate influence Andosols evolution to other order of soils. In cold and wet climates or on acid vulcanite under heavy leaching young Andosols could change into Podzols (Van Breemn and Buurman, 1998). Were investigated a Podzol soil (World References Base, 2014) at Zoniën (Belgium), were and an Andosol soil (World References Base, 2014) at Lago Laceno (Avellino, Italy). This study shows the data on the SOC (Soil Organic Carbon) fractionation in two profiles from two natural pine forest soils. Together with the conventional activities of sampling and analysis of soil profile were examined surveys meant to fractionation and characterization of SOC, in particular: Total Organic Carbon (TOC) and Total Extractable Carbon (TEC) soil contents were determined by Italian official method of soil analysis (Mi.P.A.F. (2000)). Different soil C fractions were also determined: Humic Acid Carbon (HAC), Fulvic Acid Carbon (FAC), Not Humic Carbon (NHC) and Humin Carbon (Huc) fractions were obtained by difference. In the whole profile, therefore, were also assayed cellulose and lignin contents. The aim of this work was to compare the distribution of different soil organic components in a podzol and a soil with andic properties. The data show great similarity, among the selected profiles, in the organic components distribution estudied. References: - Mi.P.A.F. - Ministero per le Politiche Agricole e Forestali - Osservatorio Nazionale Pedologico e per la Qualità del Suolo (2000): Metodi Ufficiali di Analisi Chimica del Suolo. In: Franco Angeli (Editor), Collana di metodi analitici per l'agricoltura diretta da Paolo Sequi, n. 1124.2, Milano, Italy. - Van Breemn N. and Buurman P. (1998) Chapter 12 Formation of Andisols. In: Soil formation. Kluwer Ed., Wageningen, The Netherlands, 271-289. -Ussiri D.A.N., Johnson C

  6. The role of SOCS2 in recombinant human growth hormone (rhGH) regulating lipid metabolism in high-fat-diet-induced obesity mice.

    Science.gov (United States)

    Yang, Hai Li; Feng, Min; Tan, Xiao; Yan, Guo Yong; Sun, Chao

    2013-03-01

    In addition to regulate body growth and development process, growth hormone (GH) also involved in lipid metabolism, decreasing fat mass and improving lipolysis. To normal mice, GH could reduce their fat content, but events turned uncertain coming to the pattern of feeding high-fat-diet. In order to investigate the role of GH in adipogenesis of mice with high-fat-diet, the high-fat-diet feeding mice were randomly assigned into three groups and treated with recombinant human growth hormone (rhGH) and the somatostatin analogue octreotide respectively. Results demonstrated that both rhGH and octreotide could reduce the body weight but the trends diminished in the end. HDL-C level was increased in octreotide treated groups but the activity of lipase was increased significantly in both two groups. RhGH remarkable increased the expression of SOCS2, FAS (P < 0.01) and SREBP-1c (P < 0.05), decreased the expression of SOCS1, SOCS3 (P < 0.05) and HSL (P < 0.01) in subcutaneous fat mass. In visceral fat tissue, all genes were increased except SOCS2 (P < 0.01), at the same time the visceral fat mass was decreased. The protein phosphorylation of JAK2 and STAT5 which were treated with octreotide were increased in subcutaneous fat, visceral fat and liver (P < 0.01) and were increased significant in visceral fat by rhGH treated (P < 0.01). In liver, only JAK2 protein phosphorylation was raised (P < 0.01). In conclusion, rhGH and octreotide could decrease the whole body mass before 6 days; the trend was weaken in later period with high-fat-diet. RhGH could increase the subcutaneous fat mass and reduce the visceral fat mass, and SOCS2 might be involved in regulation of the mechanism through JAK2/STAT5 signaling pathway.

  7. Japanese encephalitis virus infection modulates the expression of suppressors of cytokine signaling (SOCS) in macrophages: implications for the hosts' innate immune response.

    Science.gov (United States)

    Kundu, Kiran; Dutta, Kallol; Nazmi, Arshed; Basu, Anirban

    2013-01-01

    Viruses have evolved various mechanisms to subvert the host's immune system and one of them is preventing the infected cells from sending out chemotactic signals to activate the adaptive immune response. Japanese encephalitis virus (JEV) is a neuropathologic flavivirus that is responsible for significant number of child mortalities in various parts of South-East Asia. In this study we show that JEV modulates suppressors of cytokine signaling (SOCS)1 and 3 expression in macrophages to bring about changes in the JAK-STAT signaling cascade, so as to inhibit proinflammatory cyto/chemokine release. Using real time PCR, immunoblotting and immunofluorescent staining, we show that the expression of type 1 interferons and intracellular expression of viral genes are also affected over time. Also, following the initial activation of SOCS1 and 3, there is production of interferon-inducible anti-viral proteins in the cells which may be responsible for inhibiting viral replication. However, even at later time points, viral genes were still detected from the macrophages, albeit at lesser quantities, than earlier time points, indicative of intracellular persistence of the virus in a latent form. On knocking down SOCS1 and SOCS3 we found a significant decrease in viral gene expression at an early time point, indicating the dysregulation of the signaling cascade leading to increased production of interferon-inducible anti-viral proteins. Taken together, our study provides an insight into the role of JEV infection in modulating the JAK-STAT pathway with the help of SOCS leading to the generation of an antiviral innate immune response.

  8. p53 induces miR199a-3p to suppress SOCS7 for STAT3 activation and renal fibrosis in UUO

    Science.gov (United States)

    Yang, Ruhao; Xu, Xuan; Li, Huiling; Chen, Jinwen; Xiang, Xudong; Dong, Zheng; Zhang, Dongshan

    2017-01-01

    The role of p53 in renal fibrosis has recently been suggested, however, its function remains controversial and the underlying mechanism is unclear. Here, we show that pharmacological and genetic blockade of p53 attenuated renal interstitial fibrosis, apoptosis, and inflammation in mice with unilateral urethral obstruction (UUO). Interestingly, p53 blockade was associated with the suppression of miR-215-5p, miR-199a-5p&3p, and STAT3. In cultured human kidney tubular epithelial cells (HK-2), TGF-β1 treatment induced fibrotic changes, including collagen I and vimentin expression, being associated with p53 accumulation, p53 Ser15 phosphorylation, and miR-199a-3p expression. Inhibition of p53 by pifithrin-α blocked STAT3 activation and the expression of miR-199a-3p, collagen I, and vimentin during TGF-β1 treatment. Over-expression of miR-199a-3p increased TGFβ1-induced collagen I and vimentin expression and restored SOCS7 expression. Furthermore, SOCS7 was identified as a target gene of miR-199a-3p, and silencing of SOCS7 promoted STAT3 activation. ChIp analyses indicated the binding of p53 to the promoter region of miR-199a-3p. Consistently, kidney biopsies from patients with IgA nephropathy and diabetic nephropathy exhibited substantial activation of p53 and STAT3, decreased expression of SOCS7, and increase in profibrotic proteins and miR-199a-3p. Together, these results demonstrate the novel p53/miR-199a-3p/SOCS7/STAT3 pathway in renal interstitial fibrosis. PMID:28240316

  9. Research on the effect of the opening the ATP-sensitive K+ channels opener on airway smooth muscle cells proliferation and immune imbalance SOCS3/5%KATP通道开放剂对气道平滑肌细胞增殖表达及SOCS3/5免疫失衡的影响

    Institute of Scientific and Technical Information of China (English)

    邓伊; 王志强

    2014-01-01

    目的 研究ATP敏感性钾通道(KATP通道)开放剂对气道平滑肌细胞(ASMCs)增殖过程的影响,以及细胞因子信号转导抑制蛋白3/5 (SOCS3/5)表达变化与转化生长因子-β1(TGF-β1)分泌释放水平的关系.方法 体外构建增殖型ASMCs原代培养细胞模型,分为ASMCs组、AngⅡ.ASMCs组、淋巴细胞(L)组、ASMCs+L组和AngⅡ.ASMCs+L组.Real-time PCR检测细胞中SOCS3 mRNA及SOCS5 mRNA表达的差异;ELISA法检测上清液中TGF-β1的释放水平.观察KATP通道开放剂尼可地尔(NCR)干预的影响.结果 与ASMCs组比较,AngⅡ.ASMCs组TGF-β1的表达水平明显升高(P<0.01);NCR作用于细胞后各组ASMCs表达TGF-β1与格列本脲(GLI)比较明显减少(P<0.05).与ASMCs+L组比较,AngⅡ·ASMCs+L组SOCS3 mRNA表达增加,而SOCS5 mRNA表达减少(P<0.05).NCR可以下调SOCS3的表达,上调SOCS5的表达.结论 KATP通道开放可以通过抑制ASMCs增殖而调控TGF-β1分泌表达;SOCS3和SOCS5可能是哮喘气道重塑的特异性免疫治疗中的重要靶点.

  10. 60 GHz system-on-chip (SoC) with built-in memory and an on-chip antenna

    KAUST Repository

    Ghaffar, Farhan A.

    2014-04-01

    A novel 60 GHz transmitter SoC with an on-chip antenna and integrated memory in CMOS 65 nm technology is presented in this paper. This highly integrated transmitter design can support a data rate of 2 GBPS with a transmission range of 1 m. The transmitter consists of a fundamental frequency 60 GHz PLL which covers the complete ISM band. The modulator following the PLL can support both BPSK and OOK modulation schemes. Both stored data on the integrated memory or directly from an external source can be transmitted. A tapered slot on chip antenna is integrated with the power amplifier to complete the front end of the transmitter design. Size of the complete transmitter with on-chip antenna is only 1.96 mm × 1.96 mm. The core circuits consume less than 100 mW of power. The high data rate capability of the design makes it extremely suitable for bandwidth hungry applications such as unencrypted HD video streaming and transmission.

  11. Implementation of a wireless ECG acquisition SoC for IEEE 802.15.4 (ZigBee) applications.

    Science.gov (United States)

    Wang, Liang-Hung; Chen, Tsung-Yen; Lin, Kuang-Hao; Fang, Qiang; Lee, Shuenn-Yuh

    2015-01-01

    This paper presents a wireless biosignal acquisition system-on-a-chip (WBSA-SoC) specialized for electrocardiogram (ECG) monitoring. The proposed system consists of three subsystems, namely, 1) the ECG acquisition node, 2) the protocol for standard IEEE 802.15.4 ZigBee system, and 3) the RF transmitter circuits. The ZigBee protocol is adopted for wireless communication to achieve high integration, applicability, and portability. A fully integrated CMOS RF front end containing a quadrature voltage-controlled oscillator and a 2.4-GHz low-IF (i.e., zero-IF) transmitter is employed to transmit ECG signals through wireless communication. The low-power WBSA-SoC is implemented by the TSMC 0.18-μm standard CMOS process. An ARM-based displayer with FPGA demodulation and an RF receiver with analog-to-digital mixed-mode circuits are constructed as verification platform to demonstrate the wireless ECG acquisition system. Measurement results on the human body show that the proposed SoC can effectively acquire ECG signals.

  12. Propuesta didáctica para la enseñanza de ángulos y su medida a estudiantes de grado séptimo a partir de la recreación de algunos instrumentos de posicionamiento astronómico

    OpenAIRE

    Angarita Molina, Guzmán Olmedo

    2014-01-01

    Se presenta el análisis y respuestas observadas en un instrumento de indagación, en el que se valoran las ideas previas que tienen los estudiantes de grado séptimo de educación secundaria de la Institución Educativa Distrital la Toscana-Lisboa de la localidad de Suba, con respecto al concepto de ángulo y lo que ello involucra, su definición, notación, medición, clasificación y operaciones de suma y resta, así como su relación que tiene en fenómenos astronómicos observables y medibles como por...

  13. Seasonal and pandemic influenza H1N1 viruses induce differential expression of SOCS-1 and RIG-I genes and cytokine/chemokine production in macrophages.

    Science.gov (United States)

    Ramírez-Martínez, Gustavo; Cruz-Lagunas, Alfredo; Jiménez-Alvarez, Luis; Espinosa, Enrique; Ortíz-Quintero, Blanca; Santos-Mendoza, Teresa; Herrera, María Teresa; Canché-Pool, Elsy; Mendoza, Criselda; Bañales, José L; García-Moreno, Sara A; Morán, Juan; Cabello, Carlos; Orozco, Lorena; Aguilar-Delfín, Irma; Hidalgo-Miranda, Alfredo; Romero, Sandra; Suratt, Benjamin T; Selman, Moisés; Zúñiga, Joaquín

    2013-04-01

    Infection with pandemic (pdm) A/H1N1 virus induces high levels of pro-inflammatory mediators in blood and lungs of experimental animals and humans. To compare the involvement of seasonal A/PR/8/34 and pdm A/H1N1 virus strains in the regulation of inflammatory responses, we analyzed the changes in the whole-genome expression induced by these strains in macrophages and A549 epithelial cells. We also focused on the functional implications (cytokine production) of the differential induction of suppressors of cytokine signaling (SOCS)-1, SOCS-3, retinoid-inducible gene (RIG)-I and interferon receptor 1 (IFNAR1) genes by these viral strains in early stages of the infection. We identified 130 genes differentially expressed by pdm A/H1N1 and A/PR/8/34 infections in macrophages. mRNA levels of SOCS-1 and RIG-I were up-regulated in macrophages infected with the A/PR/8/34 but not with pdm A/H1N1 virus. mRNA levels of SOCS-3 and IFNAR1 induced by A/PR/8/34 and pdm A/H1N1 strains in macrophages, as well as in A549 cells were similar. We found higher levels of IL-6, TNF-α, IL-10, CCL3, CCL5, CCL4 and CXCL8 (p < 0.05) in supernatants from cultures of macrophages infected with the pdm A/H1N1 virus compared to those infected with the A/PR/8/34 strain, coincident with the lack of SOCS-1 and RIG-I expression. In contrast, levels of INF-α were higher in cultures of macrophages 48h after infection with the A/PR/8/34 strain than with the pdm A/H1N1 virus. These findings suggest that factors inherent to the pdm A/H1N1 viral strain may increase the production of inflammatory mediators by inhibiting SOCS-1 and modifying the expression of antiviral immunity-related genes, including RIG-I, in human macrophages. Copyright © 2013 Elsevier Ltd. All rights reserved.

  14. Cancer targeting Gene-Viro-Therapy specific for liver cancer by α-fetoprotein-controlled oncolytic adenovirus expression of SOCS3 and IL-24

    Institute of Scientific and Technical Information of China (English)

    Xin Cao; Ruicheng Wei; Xinran Liu; Yan Zeng; Hongling Huang; Miao Ding; Kangjian Zhang; Xin-Yuan Liu

    2011-01-01

    The combination of gene therapy and virotherapy for cancer treatment has received close attention and has become a trend in the field of cancer biotherapy.A strategy called 'Cancer Targeting Gene-Viro-Therapy' (CTGVT) or 'Gene Armed Oncolytic Viral Therapy'(GAOVT) has been proposed,in which an antitumor gene is inserted into an oncolytic viral vector.In our previous study,a dual-regulated oncolytic adenovirus with enhanced safety for normal cells and strict liver cancertargeting ability,designated Ad·enAFP· E1A· E1 B (A55)(briefly Ad·enAFP·D55),was successfully constructed. In the current work,interleukin-24 (IL-24) and suppressor of cytokine signaling 3 (SOCS3) genes were packaged into Ad·enAFP·D55.The new constructs,Ad·enAFP·D55-(IL-24) and Ad·enAFP·D55-(SOCS3),showed improved tumoricidal activity in hepatoma cell lines compared with the oncolytic viral vector Ad·enAFP·D55.The coadministrationofAd · enAFP· D55-(IL-24)and Ad·enAFP·D55-(SOCS3) showed much better antitumor effect than Ad·enAFP·D55-(IL-24) or Ad·enAFP·D55-(SOCS3) alone both in vitro and in a nude mouse xenograft model.Moreover,our results also showed that blockade of the Jak/Stat3 pathway by Ad·enAFP·D55-(SOCS3) infection in HuH-7 cells could down-regulate some anti-apoptosis proteins,such as XIAP,Bcl-xL,and survivin,whichmightsensitizethecellsto Ad·enAFP·D55-(IL-24)-induced apoptosis.These results indicate that co-administration of Ad·enAFP·D55-(IL-24) and Ad·enAFP·D55-(SOCS3) may serve as a candidate therapeutic approach for the treatment of liver cancer.

  15. ARM Soc Based Enotebook

    Directory of Open Access Journals (Sweden)

    Pranita C Bawankar

    2014-05-01

    Full Text Available In recent years, electronic media has grown very fast replacing papers, tape devices, books, etc. The new technologies provide large number of data into single device, fast searching options and more readability than ever. As eBooks are replacing books; we are proposing ENotebook system in which user can write as he did in notebook, save, searches and then reread content. This paper presents design and development of ENotebook using ARM7. The system uses touch screen to get input data and operations like save, delete, open & close of data file. All data sensed by touch screen is digitized by internal ADCs of LPC2148 microcontroller which gives low power platform with fast execution. The output is shown on graphical LCD. Whatever user writes on screen it may need to save for future use. The content of such hand written data will be in graphical/pictorial form hence required large of memory for storage. We can provide external memory using pen drive, memory card, EEPROM etc. in this system we are using SD card interfacing through SPI port.

  16. A low-power high-performance configurable auto-gain control loop for a digital hearing aid SoC

    Science.gov (United States)

    Chengying, Chen; Hainan, Liu; Yong, Hei; Jun, Fan; Xiaoyu, Hu

    2013-10-01

    A low-power, configurable auto-gain control loop for a digital hearing aid system on a chip (SoC) is presented. By adopting a mixed-signal feedback control structure and peak detection and judgment, it can work in automatic gain or variable gain control modes through a digital signal processing unit. A noise-reduction and dynamic range (DR) improvement technique is also used to ensure the DR of the circuit in a low-voltage supply. The circuit is implemented in an SMIC 0.13 μm 1P8M CMOS process. The measurement results show that in a 1 V power supply, 1.6 kHz input frequency and 200 mVp—p, the SFDR is 74.3 dB, the THD is 66.1 dB, and the total power is 89 μW, meeting the application requirements of hearing aid SoCs.

  17. Understanding the joint effects of family and other developmental contexts on the sense of coherence (SOC): a person-focused analysis using the Classification Tree.

    Science.gov (United States)

    García-Moya, Irene; Moreno, Carmen; Jiménez-Iglesias, Antonia

    2013-10-01

    Using a person-focused approach, the present study sought to identify meaningful constellations of contextual factors that led to predominantly high and low levels of sense of coherence (SOC). Specifically, the contributions of the quality of parent-child relationships, teacher and classmate support, models of behaviour in the peer group, and neighbourhood assets were examined in a representative sample of Spanish adolescents aged 13 to 18 that had taken part in the 2010 edition of the study Health Behaviour in School-aged Children. The quality of parent-child relationships emerged as the main predictor of SOC for the whole sample, but the remaining factors also made significant contributions, which underlines the importance of the simultaneous analysis of the main contexts in adolescents' lives. Additionally, the identified constellations usually included compensatory effects, so no factor should be considered to be completely determining. Interestingly, the role of support at school was different depending on contextual profiles.

  18. 基于CK-CORE处理器的导航SoC设计%Design on Navigation SoC Based on CK-CORE Processor

    Institute of Scientific and Technical Information of China (English)

    沈贵元; 李斌; 王铁英

    2014-01-01

    基于我国自主知识产权的CK-CORE处理器,设计了一款可满足GPS/北斗双模导航定位应用的导航SoC芯片。该芯片采用了一种结合码相位并行和频域并行的捕获算法,并且使用经典的延迟锁定环路( DLL)、频率锁定环路( FLL)和相位锁定环路( PLL)相结合的方法来实现码相位的跟踪以及载波的跟踪。进行芯片测试表明, SoC芯片定位水平误差小于10 m,灵敏度小于-145 dBm,冷启动时间小于48 s。%Based on the CK-CORE processor with Chinese independent intellectual property, the navigation SoC is designed, which can meet the demand of navigation in both GPS and BD mode.The navigation SoC adopts the acquisition algorithm which com-bines code phase parallel and frequency domain parallel.It uses the classical delay locked loop (DLL),frequency locked loop (FLL) and phase locking loop (PLL) to realize the code phase tracking and carrier tracking.The SoC test results shows that the error of SoC in navigation is less than 10 meters,the sensitivity is less than -145 dBm and the time of its cold start is less than 48 seconds.

  19. 腹腔感染时SOCS-3和GHR mRNA表达的变化与生长激素拮抗

    Institute of Scientific and Technical Information of China (English)

    王平; 李宁; 黎介寿

    2000-01-01

    @@ 腹腔感染时存在生长激素拮抗,通过测定此时SOCS-3(Suppressor of Cytoline Signaling 3),GHR(Growth Hormone Receptor)和IGF-1(Insulin-like growth factor I)mRNA表达的变化,探讨重症状态下生长激素拮抗发生的机制.

  20. (BNL/DoE-hyped) ``Self-Organized-Criticality'' (SOC) is Merely Newton's(1687) Third Law of Motion F = ma REdiscovery: LONG PRE-``Bak''!!!

    Science.gov (United States)

    Bak, P. R. E.; Newton, I.; Siegel, Edward Carl-Ludwig

    2011-03-01

    "Bak"/BNL/DoE "self-organized-criticality"(SOC) usual BNL/DoE media-hype P.R spin-doctoring "show-biz" "Bush-waaa-...-aaah!!!" is manifestly-demonstrated in two distinct ways to be nothing but Newton's Third Law of Motion F = ma REdiscovery!!! PHYSICS: (1687) cross-multiplied F = ma rewritten as 1/m = a/F = OUTPUT/INPUT = EFFECT/ CAUSE = inverse-mass mechanical-susceptibility = X ("w "); X ("w ") (F.-D. theorem-equivalence /proportionality) P("w ") "noise" power-spectrum; E w ; and E (any/all media upper-limiting-speeds) m. Thus: w E m; inversion yields: 1/w 1 /E 1 /m a/F = X ("w ") P("w "); hence: F = ma dual/inverse-integral-transform is "'SOC"'s" P(w) 1 / w (1) !!! ; "PURE"-MATHS: F = ma double-integral time-series s(t) = [vot + (1/2) at (2) ] inverse/dual-integral-transform formally defines power-spectrum: P (w) = S { s (t) e [ - (iORnoi) wt ] } dt = S { [ vot + (1 / 2) at 2) ] e [ - (iORnoi) wt ] } dt = voS { te [ - (iORnoi) wt ] } dt + (1 / 2) S { [ a = / = a (t) ] e [ - (iORnoi) wt) } dt = vo (d / dw) Delta (w) + (1 / 2) [ a = / = a (t) ] (d / dw) (2) Delta (w) = vo / w (0) + (1 / 2) [ a = / = a (t) ] / w 1 : ifa = 0 , then P(w) 1 / w 0 , VS . ifa = / = a (t) = / = 0 , then P(w) 1 /w; = by physics: ``SOC'' RE-expresses F = ma!!!: ``just `a tad' late/tardy'' REdiscovery of F=ma: LONG PRE-"Bak"!!!

  1. A strongly greenish-blue-emitting Cu4Cl4 cluster with an efficient spin-orbit coupling (SOC): fast phosphorescence versus thermally activated delayed fluorescence.

    Science.gov (United States)

    Chen, Xu-Lin; Yu, Rongmin; Wu, Xiao-Yuan; Liang, Dong; Jia, Ji-Hui; Lu, Can-Zhong

    2016-05-07

    In this communication, we report a new greenish-blue-emitting Cu(i) complex, Cu4Cl4(NP)2, a with high photoluminescence quantum yield of 90% and a short decay time of 9.9 μs. Due to the strong SOC combined with the small activation energy ΔEST, the emission at room temperature consists of approximately equivalent fast phosphorescence and TADF.

  2. A 1.83 μJ/Classification, 8-Channel, Patient-Specific Epileptic Seizure Classification SoC Using a Non-Linear Support Vector Machine.

    Science.gov (United States)

    Bin Altaf, Muhammad Awais; Yoo, Jerald

    2016-02-01

    A non-linear support vector machine (NLSVM) seizure classification SoC with 8-channel EEG data acquisition and storage for epileptic patients is presented. The proposed SoC is the first work in literature that integrates a feature extraction (FE) engine, patient specific hardware-efficient NLSVM classification engine, 96 KB SRAM for EEG data storage and low-noise, high dynamic range readout circuits. To achieve on-chip integration of the NLSVM classification engine with minimum area and energy consumption, the FE engine utilizes time division multiplexing (TDM)-BPF architecture. The implemented log-linear Gaussian basis function (LL-GBF) NLSVM classifier exploits the linearization to achieve energy consumption of 0.39 μ J/operation and reduces the area by 28.2% compared to conventional GBF implementation. The readout circuits incorporate a chopper-stabilized DC servo loop to minimize the noise level elevation and achieve noise RTI of 0.81 μ Vrms for 0.5-100 Hz bandwidth with an NEF of 4.0. The 5 × 5 mm (2) SoC is implemented in a 0.18 μm 1P6M CMOS process consuming 1.83 μ J/classification for 8-channel operation. SoC verification has been done with the Children's Hospital Boston-MIT EEG database, as well as with a specific rapid eye-blink pattern detection test, which results in an average detection rate, average false alarm rate and latency of 95.1%, 0.94% (0.27 false alarms/hour) and 2 s, respectively.

  3. Additional results for "joint entropy of continuously differentiable ultrasonic waveforms" [J. Acoust. Soc. Am. 133(1), 283-300 (2013)].

    Science.gov (United States)

    Hughes, M S; Marsh, J N; Wickline, S A; McCarthy, J E

    2015-01-01

    Previous results on the use of joint entropy for detection of targeted nanoparticles accumulating in the neovasculature of MDA435 tumors [Fig. 7 of M. S. Hughes et al., J. Acoust. Soc. Am. 133, 283-300 (2013)] are extended, with sensitivity improving by nearly another factor of 2. This result is obtained using a "quasi-optimal" reference waveform in the computation of the joint entropy imaging technique used to image the accumulating nanoparticles.

  4. Research on optimal power allocation strategy based on SOC state feedback in hybrid energy storage system%基于 SOC 状态反馈的混合储能功率优化策略

    Institute of Scientific and Technical Information of China (English)

    孙纯军; 倪春花; 窦晓波

    2016-01-01

    文中储能系统功率优化分配以一阶惯性滤波系统为基础,介绍了滤波系数的确定方法,首先提出了基于频谱分析的混合储能系统功率分配方法,根据频谱分析结果,确定波动功率在蓄电池与超级电容之间的分配;在频谱分析的基础上,进一步提出了基于SOC状态反馈的混合储能系统功率优化分配方法,并采用模糊控制,根据储能系统荷电状态SOC的值实时调整系统的滤波时间参数,从而实现超级电容-蓄电池储能系统的长期有效运行。最后,在PSCAD/EMTDC中搭建微电网仿真模型,并设计仿真方案,通过仿真验证所提混合储能系统功率优化分配策略的有效性。%Energy storage system has an important significance for reliable and stable operation of micro-grids.Con-sidering the lack of single form of energy storage, ultra-capacitor-battery hybrid energy storage system is used in this paper.Strategies of power distribution of energy storage system are based on first order inertial filter system, and the method to determine the filter coefficients are introduced.Firstly, a method based on spectrum analysis is proposed to distribute the fluctuated power between the battery and ultra-capacitor.Next, a power distribution strategy of hybrid energy storage system based on SOC feedback is proposed.And fuzzy control method is adopted to adjust system pa-rameters in real time according to the state of charge of the storage system, thus achieving the long term operation of hybrid energy storage system.Finally, the models are built in PSCAD /EMTDC to verify the effectiveness of the pow-er distribution strategies through simulation according to the designed projects.

  5. Rheumatoid Arthritis-Associated MicroRNA-155 Targets SOCS1 and Upregulates TNF-α and IL-1β in PBMCs

    Directory of Open Access Journals (Sweden)

    Xiaochuan Li

    2013-12-01

    Full Text Available miR-155 plays a crucial role in proinflammatory activation. This study was carried out to assess the association of abnormal expression of miR-155 in peripheral blood of patients with Rheumatoid arthritis with the expression of TNF-α and IL-1β. Release of TNF-α and IL-1β, and expression of miR-155 were determined in RA peripheral blood or peripheral blood macrophages, followed by correlation analysis of the cytokines release and miR-155 expression. Furthermore, in vitro studies indicate that miR-155 inhibited the expression of SOCS1. Our results suggest that there is a correlation between the high-level expression of miR-155 and the enhanced expression of TNF-α and IL-1β. miR-155 targets and suppresses the expression of SOCS1, and the decrease of SOCS1 may lead to the upregulation of TNF-α and IL-1β.

  6. A respiratory syncytial virus persistent-infected cell line system reveals the involvement of SOCS1 in the innate antiviral response

    Institute of Scientific and Technical Information of China (English)

    Junwen; Zheng; Pu; Yang; Yan; Tang; Dongchi; Zhao

    2015-01-01

    HEp-2 cells persistently infected with respiratory syncytial virus(RSV) are a heterogeneous mixture of viral antigen-positive and-negative variants; however, the mechanism through which viral replication becomes latent remains unclear. In this study, we investigated the potential mechanism by which RSV escapes from innate immune surveillance. Persistent-infected RSV HEp-2 cells were isolated and cell clones were passaged. The RSV-persistent cells produced viruses at a lower titer, resisted wild-type RSV re-infection, and secreted high levels of interferon-β(IFN-β), macrophage inflammatory protein-1α(Mip-1α), interleukin-8(IL-8), and Rantes. Toll-like receptor 3(TLR3), retinoic acid inducible gene-I(RIG-I), and suppressor of cytokine signaling 1(SOCS1) levels were upregulated in these cells. The silencing of TLR3 m RNA decreased the expression of SOCS1 protein and the secretion of cytokines. RSV-persistent cells are in an inflammatory state; upregulation of SOCS1 is related to the TLR3 signaling pathway, which could be associated with the mechanism of viral persistence.

  7. MPT0B098, a Microtubule Inhibitor, Suppresses JAK2/STAT3 Signaling Pathway through Modulation of SOCS3 Stability in Oral Squamous Cell Carcinoma.

    Directory of Open Access Journals (Sweden)

    Hsuan-Yu Peng

    Full Text Available Microtubule inhibitors have been shown to inhibit Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3 signal transduction pathway in various cancer cells. However, little is known of the mechanism by which the microtubule inhibitors inhibit STAT3 activity. In the present study, we examined the effect of a novel small-molecule microtubule inhibitor, MPT0B098, on STAT3 signaling in oral squamous cell carcinoma (OSCC. Treatment of various OSCC cells with MPT0B098 induced growth inhibition, cell cycle arrest and apoptosis, as well as increased the protein level of SOCS3. The accumulation of SOCS3 protein enhanced its binding to JAK2 and TYK2 which facilitated the ubiquitination and degradation of JAK2 and TYK2, resulting in a loss of STAT3 activity. The inhibition of STAT3 activity led to sensitization of OSCC cells to MPT0B098 cytotoxicity, indicating that STAT3 is a key mediator of drug resistance in oral carcinogenesis. Moreover, the combination of MPT0B098 with the clinical drug cisplatin or 5-FU significantly augmented growth inhibition and apoptosis in OSCC cells. Taken together, our results provide a novel mechanism for the action of MPT0B098 in which the JAK2/STAT3 signaling pathway is suppressed through the modulation of SOCS3 protein level. The findings also provide a promising combinational therapy of MPT0B098 for OSCC.

  8. 基于覆盖率驱动的SoC验证技术研究%Research of SoC Verification Technology Based on Coverage--Driven

    Institute of Scientific and Technical Information of China (English)

    朱车壮; 陈岚; 冯燕

    2011-01-01

    Coverage data--base is the qualitative measurement for the verification engineer to judge the complete degree of SoC verification, and it provides the safeguard for the SoC validation completeness. This paper takes the verification of SoC bus arbiter as an example, analyzes many kinds of coverage in detail, for example, structure coverage, functional coverage, assertion coverage and so on, then modifies the RTL design code and testcases based on the analysis results of these coverage, until the integrity of the verification meet the design requirements.%覆盖率数据是验证工程师判定SoC验证完备程度的定性度量,为SoC验证完全性提供了保障,指明了方向.文中以SoC总线仲裁器验证为例,对其结构覆盖率、功能覆盖率、断言覆盖率等多种覆盖率进行了全面的分析,然后根据覆盖率分析结果反馈到RTL设计代码和测试激励进行修正,直到验证的完整性满足设计的要求.

  9. A 1.5-to-5 V converter for a battery-powered activity-dependent intracortical microstimulation SoC.

    Science.gov (United States)

    Azin, Meysam; Mohseni, Pedram

    2012-01-01

    This paper reports on the design, analysis, implementation, and testing of a 1.5-to-5 V converter as part of a battery-powered activity-dependent intracortical microstimulation (ICMS) system-on-chip (SoC) that converts extracellular neural spikes recorded from one cortical area to electrical stimuli delivered to another cortical area in real time. The highly integrated voltage converter is intended to generate a 5-V supply for the stimulating back-end on the SoC from a miniature primary battery that powers the entire system. It is implemented in AMS 0.35 µm two-poly four-metal (2P/4M) complementary metal-oxide-semiconductor (CMOS) technology, employs only one external capacitor (1 µF) for storage, and delivers a maximum dc load current of ~88 µA with power efficiency of 31% with its output voltage adjusted to 5.05 V. This current drive capability affords simultaneous stimulation on all eight channels of the SoC with current amplitude up to ~100 µA and average stimulus rate >500 Hz, which is comfortably higher than firing rate of cortical neurons (<150 spikes per second). The measurement results also agree favorably with theoretical derivations from the analysis of converter operation.

  10. A 6.45 μW Self-Powered SoC With Integrated Energy-Harvesting Power Management and ULP Asymmetric Radios for Portable Biomedical Systems.

    Science.gov (United States)

    Roy, Abhishek; Klinefelter, Alicia; Yahya, Farah B; Chen, Xing; Gonzalez-Guerrero, Luisa Patricia; Lukas, Christopher J; Kamakshi, Divya Akella; Boley, James; Craig, Kyle; Faisal, Muhammad; Oh, Seunghyun; Roberts, Nathan E; Shakhsheer, Yousef; Shrivastava, Aatmesh; Vasudevan, Dilip P; Wentzloff, David D; Calhoun, Benton H

    2015-12-01

    This paper presents a batteryless system-on-chip (SoC) that operates off energy harvested from indoor solar cells and/or thermoelectric generators (TEGs) on the body. Fabricated in a commercial 0.13 μW process, this SoC sensing platform consists of an integrated energy harvesting and power management unit (EH-PMU) with maximum power point tracking, multiple sensing modalities, programmable core and a low power microcontroller with several hardware accelerators to enable energy-efficient digital signal processing, ultra-low-power (ULP) asymmetric radios for wireless transmission, and a 100 nW wake-up radio. The EH-PMU achieves a peak end-to-end efficiency of 75% delivering power to a 100 μA load. In an example motion detection application, the SoC reads data from an accelerometer through SPI, processes it, and sends it over the radio. The SPI and digital processing consume only 2.27 μW, while the integrated radio consumes 4.18 μW when transmitting at 187.5 kbps for a total of 6.45 μW.

  11. Niflumic acid affects store-operated Ca(2+)-permeable (SOC) and Ca (2+)-dependent K (+) and Cl (-) ion channels and induces apoptosis in K562 cells.

    Science.gov (United States)

    Kucherenko, Yuliya V; Lang, Florian

    2014-07-01

    Non-steroidal anti-inflammatory drugs (NSAIDs) are known to induce apoptosis in a variety of cancer cells. However, the precise mechanisms by which NSAIDs facilitate apoptosis in tumor cells are not clear. In the present study, we show that niflumic acid (NA), a member of the fenamates group of NSAIDs and Cl(-) and Ca(2+)-activated Cl(-) (CAC) channels blocker, induced apoptosis (by ~8 %, 24 h treatment) and potentiated (by 8-10 %) apoptotic effect of endoplasmic reticulum Ca(2+) mobilizer thapsigargin (Tg) in human erythroleukemic K562 cell line. The whole-cell patch clamp and Fluo-3 flow cytometric experiments confirmed an inhibitory effect of NA (100 and 300 µM) on store-operated (SOC) channels. We also found that NA-blocked CAC channels were activated by acute application of Tg (2 µM) in K562 cells. NA blockage of CAC channels was accompanied by activation of Ca(2+)-activated K(+) (SK4) channels. The observed effects of NA were not connected with COX-2 inhibition since 100-nM NA (IC50 for COX-2 inhibition) did not induce either apoptosis or affect the channels activity. We conclude that inhibition of SOC channels plays a major role in NA-induced apoptosis. Increased apoptotic levels in Tg-treated K562 cells in the presence of NA may be due to the blockage of CAC and stimulation of SK4 channels in addition to SOC channels inhibition.

  12. Assembly of the small outer capsid protein, Soc, on bacteriophage T4: a novel system for high density display of multiple large anthrax toxins and foreign proteins on phage capsid.

    Science.gov (United States)

    Li, Qin; Shivachandra, Sathish B; Zhang, Zhihong; Rao, Venigalla B

    2007-07-27

    Bacteriophage T4 capsid is a prolate icosahedron composed of the major capsid protein gp23*, the vertex protein gp24*, and the portal protein gp20. Assembled on its surface are 810 molecules of the non-essential small outer capsid protein, Soc (10 kDa), and 155 molecules of the highly antigenic outer capsid protein, Hoc (39 kDa). In this study Soc, a "triplex" protein that stabilizes T4 capsid, is targeted for molecular engineering of T4 particle surface. Using a defined in vitro assembly system, anthrax toxins, protective antigen, lethal factor and their domains, fused to Soc were efficiently displayed on the capsid. Both the N and C termini of the 80 amino acid Soc polypeptide can be simultaneously used to display antigens. Proteins as large as 93 kDa can be stably anchored on the capsid through Soc-capsid interactions. Using both Soc and Hoc, up to 1662 anthrax toxin molecules are assembled on the phage T4 capsid under controlled conditions. We infer from the binding data that a relatively high affinity capsid binding site is located in the middle of the rod-shaped Soc, with the N and C termini facing the 2- and 3-fold symmetry axes of the capsid, respectively. Soc subunits interact at these interfaces, gluing the adjacent capsid protein hexamers and generating a cage-like outer scaffold. Antigen fusion does interfere with the inter-subunit interactions, but these interactions are not essential for capsid binding and antigen display. These features make the T4-Soc platform the most robust phage display system reported to date. The study offers insights into the architectural design of bacteriophage T4 virion, one of the most stable viruses known, and how its capsid surface can be engineered for novel applications in basic molecular biology and biotechnology.

  13. Relations between Microwave Bursts and near-Earth High-Energy Proton Enhancements and their Origin

    CERN Document Server

    Grechnev, V V; Meshalkina, N S; Chertok, I M

    2015-01-01

    We further study the relations between parameters of bursts at 35 GHz recorded with the Nobeyama Radio Polarimeters during 25 years, on the one hand, and solar proton events, on the other hand (Grechnev et al. in Publ. Astron. Soc. Japan 65, S4, 2013a). Here we address the relations between the microwave fluences at 35 GHz and near-Earth proton fluences above 100 MeV in order to find information on their sources and evaluate their diagnostic potential. A correlation was found to be pronouncedly higher between the microwave and proton fluences than between their peak fluxes. This fact probably reflects a dependence of the total number of protons on the duration of the acceleration process. In events with strong flares, the correlation coefficients of high-energy proton fluences with microwave and soft X-ray fluences are higher than those with the speeds of coronal mass ejections. The results indicate a statistically larger contribution of flare processes to high-energy proton fluxes. Acceleration by shock wave...

  14. Neutrophil and monocyte responses to downhill running: Intracellular contents of MPO, IL-6, IL-10, pstat3, and SOCS3.

    Science.gov (United States)

    van de Vyver, M; Engelbrecht, L; Smith, C; Myburgh, K H

    2016-06-01

    High-intensity exercise results in immune activation. This study determined whether (a) there is concordance between serum MPO and neutrophil and/or monocyte intracellular MPO content; (b) peripheral blood mononuclear cells respond to inflammatory interleukins (ILs) by increasing intracellular signaling. Healthy male (n = 12) volunteers participated in high-intensity running (12 × 5 min, 10% decline, 15 km/h). Blood sample (pre, post, 4 h) analyses included serum concentrations of IL-1β, IL-1ra, IL-4, IL-6, IL-8, IL-10, matrix metalloprotease-9 (MMP-9) and creatine kinase (CK). Intracellular IL-6, IL-10, MPO and STAT3/SOCS3 signaling were assessed in mononuclear cells. CK (1573 ± 756 u/L), MMP-9 (101 ± 27 ng/mL), neutrophil (9.89 ± 0.76 × 10(9) cells/L) and monocyte counts (1 ± 0.08 × 10(9) cells/L) increased at 4 h. At 4 h serum (7.1 ± 1.3 ng/mL) and monocyte MPO (1.7-fold) increased, whereas neutrophil MPO decreased (0.8-fold). Intracellular monocyte IL-10 and IL-6 decreased by 15% and 20-30%, respectively, coinciding with elevations in serum IL-10 of 14.5 ± 4.7 pg/mL and IL-6 of 5.4 ± 2.9 pg/mL, suggesting immune cell cytokine release in response to exercise. Intracellular PBMC p-STAT3 to total STAT3 ratio increased from pre to 4 h. Circulating monocytes are responsive to increased serum IL-6 suggesting a negative feedback loop via STAT3 signaling. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  15. Soil cover patterns and SOC dynamics impacts on the soil processes, land management and ecosystem services in Central Region of Russia

    Science.gov (United States)

    Vasenev, Ivan; Chernikov, Vladimir; Yashin, Ivan; Geraskin, Mikhail; Morev, Dmitriy

    2014-05-01

    In the Central Region of Russia (CRR) the soil cover patterns usually play the very important role in the soil forming and degradation processes (SFP & SDP) potential and current rates, soil organic carbon (SOC) dynamics and pools, greenhouse gases (GHG) emissions and soluble SOC fluxes that we need take into attention for better assessment of the natural and especially man-changed ecosystems' services and for best land-use practices development. Central Region of Russia is the biggest one in RF according to its population and role in the economy. CRR is characterized by high spatial variability of soil cover due to as original landscape heterogeneity as complicated history of land-use practices during last 700 years. Our long-term researches include the wide zonal-provincial set of representative ecosystems and soil cover patterns with different types and history of land-use (forest, meadow-steppe and agricultural ones) from middle-taiga to steppe zones with different level of continentality. The carried out more than 30-years region- and local-scale researches of representative natural and rural landscapes in Tver', Yaroslavl', Kaluga, Moscow, Vladimir, Saransk (Mordovia), Kursk, Orel, Tambov, Voronezh and Saratov oblasts give us the interregional multi-factorial matrix of elementary soil cover patterns (ESCP) with different soil forming and degradation processes rates and soil organic carbon dynamics due to regionally specific soil-geomorphologic features, environmental and dominated microclimate conditions, land-use current practices and history. The validation and ranging of the limiting factors of SFP and SDP develop¬ment, soil carbon dynamics and sequestration potential, ecosystem (agroecosystem) principal services, land functional qualities and agroecological state have been done for dominating and most dynamical components of ESCP regional-typological forms - with application of SOC structure analysis, regional and local GIS, soil spatial patterns detail

  16. Methylation Status of theSOCS3 Gene Promoter in H2228 Cells and EML4-ALK-positive Lung Cancer Tissues%H2228细胞和EML4-ALK阳性肺癌组织中SOCS3基因启动子区甲基化状态的研究

    Institute of Scientific and Technical Information of China (English)

    刘春来; 李永文; 董云龙; 张洪兵; 李颖; 刘红雨; 陈军

    2016-01-01

    Background and objective TheEML4-ALK fusion gene is a newly discovered driver gene of non-small cell lung cancer and exhibits special clinical and pathological features. hTe JAK-STAT signaling pathway, an important downstream signaling pathway of EML4-ALK, is aberrantly sustained and activated in EML4-ALK-positive lung cancer cells fusion gene, but the underlying reason remains unknown. hTe suppressor of cytokine signaling (SOCS) is a negative regula-tory factor that mainly inhibits the proliferation, differentiation, and induction of apoptotic cells by inhibiting the JAK-STAT signaling pathway. hTe aberrant methylation of theSOCS gene leads to inactivation of tumors and abnormal activation of the JAK2-STAT signaling pathway. hTe aim of this study is to investigate the methylation status of the SOCS3 promoter in EML4-ALK-positive H2228 cells and lung cancer tissues.Methods hTe methylation status of the SOCS3 promoter in EML4-ALK-positive H2228 lung cancer cells and lung cancer tissues was detected by methylation-speciifc PCR (MSP) analysis and veri-ifed by DNA sequencing. hTe expression levels of SOCS3 in H2228 cells were detected by Western blot and Real-time PCR analyses atfer treatment with the DNA methyltransferase inhibitor 5'-Aza-dC.Results MSP and DNA sequencing assay results indicated the presence of SOCS3 promoter methylation in H2228 cells as well as in three cases of seven EML4-ALK-positive lung cancer tissues. hTe expression level of SOCS3 signiifcantly increased in H2228 cells atfer 5′-Aza-dC treatment.Conclu-sion hTe aerrant methylation of the SOCS3 promoter region in EML4-ALK (+) H2228 cells and lung cancer tissues may be signiifcantly involved in the pathogenesis of EML4-ALK-positive lung cancer.%背景与目的人类棘皮动物微管相关蛋白样4(echinoderm microtubule-associated-protein-like 4,EML4)和人类间变性淋巴瘤激酶(anaplastic lymphoma kinase,ALK)融合基因EML4-ALK是新发现的非小细胞肺癌的驱动基因,

  17. 磷酸铁锂锂离子电池EIS参数随SOC变化的规律%Relation between EIS parameters and SOC change of LiFePO4 Li-ion battery

    Institute of Scientific and Technical Information of China (English)

    席安静; 田光宇; 白鹏

    2012-01-01

    为准确估计磷酸铁锂(LiFePO4)锂离子电池的荷电状态(SOC),测量了商用18650型电池在不同SOC下的电化学阻抗谱(EIS),对中频区的EIS谱进行研究.分析了电荷转移内阻RCT、双电层电容Cdl、过渡频率f、串联电阻Rs和串联电容Cs随SOC变化的规律.在一定的频率下,Cs随SOC的变化单调递减,可作为估计LiFePO4锂离子电池SOC的参数.%In order to estimate the state of charge(SOC)of lithium iron phosphate(LiFePO4)Li-ion battery with high accuracy, the electrochemical impedance spectroscopy( EIS) of commercial 18650 type battery under different SOC was tested, the EIS plots middle frequency range was studied. The relation between SOC changing and the EIS parameters such as charge transfer resistance RCT>double layer capacitor Cdl, transitional frequency f,series resistance RB and series capacitor CB was analyzed. The CB demonstrated the monotonous change with SOC at a certain frequency,could be used as parameter of estimating SOC for LiFePO4 Li-ion battery.

  18. Monocyte chemoattractant protein-1 secreted by decidual stromal cells inhibits NK cells cytotoxicity by up-regulating expression of SOCS3.

    Directory of Open Access Journals (Sweden)

    Xiaofei Xu

    Full Text Available BACKGROUND: Decidual stromal cells (DSCs are of particular importance due to their pleiotropic functions during pregnancy. Although previous research has demonstrated that DSCs participated in the regulation of immune cells during pregnancy, the crosstalk between DSCs and NK cells has not been fully elucidated. To address this issue, we investigated the effect of DSCs on perforin expression in CD56(+ NK cells and explored the underlying mechanism. METHODOLOGY/PRINCIPAL FINDINGS: Flow cytometry analysis showed perforin production in NK cells was attenuated by DSC media, and it was further suppressed by media from DSCs pretreated with lipopolysaccharide (LPS. However, the expression of granzyme A and apoptosis of NK cells were not influenced by DSC media. ELISA assays to detect cytokine production indicated that monocyte chemoattractant protein-1 (MCP-1 in the supernatant of DSCs conditioned culture significantly increased after LPS stimulation. The inhibitory effect of DSC media on perforin was abolished by the administration of anti-MCP-1 neutralizing antibody. Notably, reduced perforin expression attenuated the cytotoxic potential of CD56(+ NK cells to K562 cells. Moreover, Suppressor of cytokine signaling 3 (SOCS3 expression in NK cells was enhanced by treatment with MCP-1, as measured by RT-PCR and western blot. Interestingly, MCP-1-induced perforin expression was partly abolished by the siRNA induced SOCS3 knockdown. Western blot analysis suggested that both NF-κB and ERK/MAPKs pathway were involved in the LPS-induced upregulation of MCP-1 in DSCs. CONCLUSIONS/SIGNIFICANCE: Our results demonstrate that LPS induces upregulation of MCP-1 in DSCs, which may play a critical role in inhibiting the cytotoxicity of NK cells partly by promoting SOCS3 expression. These findings suggest that the crosstalk between DSCs and NK cells may be crucial to maintain pregnancy homeostasis.

  19. A method for the densification of ceramic layers, especially ceramic layers within solid oxide cell (SOC) technology, and products obtained by the method

    DEFF Research Database (Denmark)

    2013-01-01

    A ceramic layer, especially for use in solid oxide cell (SOC) technology, is densified in a method comprising (a) providing a multilayer system by depositing the porous ceramic layer, which is to be densified, onto the selected system of ceramic layers on a support, (b) pre-sintering the resulting......(s) in the porous layer surface and (e) performing a thermal treatment at a temperature T2, where T2 > ?1, to obtain densification of and grain growth in the porous layer formed in step (b). The method makes it possible to obtain dense ceramic layers at temperatures, which are compatible with the other materials...... present in a ceramic multilayer system....

  20. 一种改进的层次化SOCs并行测试封装扫描单元%A Modified Parallel Wrapper Cell for Hierarchical SOCs Test

    Institute of Scientific and Technical Information of China (English)

    邓立宝; 乔立岩; 俞洋; 彭喜元

    2012-01-01

    测试封装是实现SOC内部IP核可测性和可控性的关键,而扫描单元是测试封装最重要的组成部分.然而传统的测试封装扫描单元在应用于层次化SOCs测试时存在很多缺点,无法保证内部IP核的完全并行测试,并且在测试的安全性,功耗等方面表现出很大问题.本文提出一种改进的层次化SOCs测试封装扫描单元结构,能够有效解决上述问题,该结构的主要思想是对现有的扫描单元进行改进,实现并行测试的同时,通过在适当的位置增加一个传输门,阻止无序的数据在非测试时段进入IP核,使得IP核处于休眠状态,保证了测试的安全性,实现了测试时的低功耗.最后将这种方法应用在一个工业上的层次化SOCs,实验分析表明,改进的测试封装扫描单元比现有扫描单元在增加较小硬件开销的前提下,在并行测试、低功耗、测试安全性和测试覆盖率方面有着明显的优势.%Test wrapper,which to make IP cores in SOC measurable and controllable,is the key architecture,and its important part is wrapper cell.Traditional test wrapper has many shortcomings,such as parallel test,test secure and test power,when used in hierarchical SOCs.This paper presented a modified test wrapper design for embedded IP cores,which only inserted a CMOS transmission gate to the test wrapper cell to eliminate the precarious effect to IP cores,to make the IP cores dormancy.Experiments on an industry hierarchical SOCs show that the proposed test wrapper cell not only takes less area overhead and time delay,but also make test parallel,secure and fully,thus decreases the dynamic test power during scan shifting.

  1. Pharmacogenetics of efficacy and safety of HCV treatment in HCV-HIV coinfected patients: significant associations with IL28B and SOCS3 gene variants.

    Directory of Open Access Journals (Sweden)

    Francesc Vidal

    Full Text Available BACKGROUND AND AIMS: This was a safety and efficacy pharmacogenetic study of a previously performed randomized trial which compared the effectiveness of treatment of hepatitis C virus infection with pegylated interferon alpha (pegIFNα 2a vs. 2b, both with ribavirin, for 48 weeks, in HCV-HIV coinfected patients. METHODS: The study groups were made of 99 patients (efficacy pharmacogenetic substudy and of 114 patients (safety pharmacogenetic substudy. Polymorphisms in the following candidate genes IL28B, IL6, IL10, TNFα, IFNγ, CCL5, MxA, OAS1, SOCS3, CTLA4 and ITPA were assessed. Genotyping was carried out using Sequenom iPLEX-Gold, a single-base extension polymerase chain reaction. Efficacy end-points assessed were: rapid, early and sustained virological response (RVR, EVR and SVR, respectively. Safety end-points assessed were: anemia, neutropenia, thrombocytopenia, flu-like syndrome, gastrointestinal disturbances and depression. Chi square test, Student's T test, Mann-Whitney U test and logistic regression were used for statistic analyses. RESULTS: As efficacy is concerned, IL28B and CTLA4 gene polymorphisms were associated with RVR (p<0.05 for both comparisons. Nevertheless, only polymorphism in the IL28B gene was associated with SVR (p = 0.004. In the multivariate analysis, the only gene independently associated with SVR was IL28B (OR 2.61, 95%CI 1.2-5.6, p = 0.01. With respect to safety, there were no significant associations between flu-like syndrome or depression and the genetic variants studied. Gastrointestinal disturbances were associated with ITPA gene polymorphism (p = 0.04. Anemia was associated with OAS1 and CTLA4 gene polymorphisms (p = 0.049 and p = 0.045, respectively, neutropenia and thromobocytopenia were associated with SOCS3 gene polymorphism (p = 0.02 and p = 0.002, respectively. In the multivariate analysis, the associations of the SOCS3 gene polymorphism with neutropenia (OR 0.26, 95%CI 0

  2. RRS Discovery Cruise 249, 19 Aug-10 Sep 2000. History of sedimentation in the Gulf of Cadiz: investigations with the SOC giant piston corer

    OpenAIRE

    Weaver, P.P.E.

    2003-01-01

    This was the third cruise using the new SOC giant piston corer. The objectives were to complete the testing of the giant piston corer which was begun on cruise D219 in November/December 1995 and cruise D225 in February/March 1997, and to collect giant piston cores from the Gulf of Cadiz on sites selected from the TOBI survey carried out on cruise D244 in December 1999. As on previous cruises we had problems with both the ships equipment (outboard sheave on coring gantry), and the giant pist...

  3. Lack of association between the tagging SNP A+930-->G of SOCS3 and type 2 diabetes mellitus: meta-analysis of four independent study populations.

    Directory of Open Access Journals (Sweden)

    Antje Fischer-Rosinsky

    Full Text Available BACKGROUND: The suppressor of cytokine signalling 3 (SOCS3 provides a link between cytokine action and their negative consequences on insulin signalling. Thus SOCS3 is a potential candidate gene for type 2 diabetes (T2DM. METHODOLOGY/PRINCIPAL FINDINGS: Based on HapMap we identified the polymorphism A+930-->G (rs4969168 as a haplotype tagging SNP (htSNP sufficiently covering the genetic variation of the whole gene. We therefore examined the association between rs4969168 within SOCS3 and T2DM in three independent study populations; one prospective case-cohort study and two cross-sectional study populations. Due to the low frequency of individuals being homozygous for the polymorphism a dominant model of inheritance was assumed. The case-cohort study with 2,957 individuals (764 of them with incident T2DM showed no effect of the polymorphism on diabetes risk (hazard ratio (95%CI: 0.86 (0.66-1.13; p = 0.3. Within the MeSyBePo-study population 325 subjects had T2DM from a total of 1,897 individuals, while the second cross-sectional cohort included 851 cases of T2DM within a total of 1653 subjects. According to the results in the prospective study, no association with T2DM was found (odds ratio (95%CI: 0.78 (0.54-1.12 for MesyBepo and 1.13 (0.90-1.42 for the Leipzig study population. There was also no association with metabolic subtraits such as insulin sensitivity (p = 0.7, insulin secretion (p = 0.8 or the hyperbolic relation of both, the disposition index (p = 0.7. In addition, no evidence for interaction with BMI or sex was found. We subsequently performed a meta-analysis, additionally including the publicly available data from the T2DM-subcohort of the WTCCC (n = 4,855. The overall odds ratio within that meta-analysis was 0.96 (0.88-1.06. CONCLUSIONS/SIGNIFICANCE: There is no strong effect of the common genetic variation within the SOCS3 gene on the development of T2DM.

  4. Overexpression of miR -155 promotes proliferation and invasion of human laryngeal squamous cell carcinoma via targeting SOCS1 and STAT3.

    Directory of Open Access Journals (Sweden)

    Xu-dong Zhao

    Full Text Available MicroRNA155 plays an important role in many solid malignancies. Expression and function of miR-155 in laryngeal carcinoma have not been fully understood. This study aims to investigate the expression and function of miR-155 in laryngeal squamous cell carcinoma (LSCC, the relationship between miR-155 and its downstream target suppressor of cytokine signaling 1 (SOCS1-STAT3 pathway, and the related clinicopathological factors. Sixty-three samples of laryngeal squamous cell carcinoma and twenty-one samples of control mucosa obtained from total laryngectomy cases were analyzed using Western blot analysis and real-time PCR. Hep-2 cells were cultured and transfected with miR-155 mimic and ASO. Cell proliferation, migration and invasion assays were used to determine the role of miR-155 in regulation of LSCC growth, migration, and invasion, respectively. The expression levels of miR-155 in LSCC were significantly higher than those in the control mucosa tissues. Downregulation of SOCS1 expression and elevated expression of STAT3 were also observed in LSCC. The relevance of the three factors were statistically significant. Moreover, knockdown of miR-155 elevated SOCS1expression level, suppressed STAT3 expression, and inhibited hep-2 cells growth, migration and invasion. Whereas overexpression of miR-155 inhibited SOCS1expression, elevated STAT3 expression, and promoted hep-2 cells growth, migration and invasion. Furthermore, the miR-155 levels in T(3 T(4 stages, and poor/moderate cell differentiation were significantly higher than those in T(2 stage and higher degree of cell differentiation. The STAT3 protein in poor/moderate cell differentiation was significantly higher than those in higher degree of cell differentiation. We firstly demonstrated the aberrant expression and function of miR-155 and itsdownstream targets in LSCC. The current findings suggest that miR-155 play promotingrole during the development of LSCC, and miR-155 may be a useful marker

  5. 两种先进的封装技术--SOC和SOP%The Both Advantages Packaging Tehnology with SOC and SOP

    Institute of Scientific and Technical Information of China (English)

    胡志勇

    2004-01-01

    为了能够实现通过集成所获得的优点,像高性能、低价格、较小的接触面、电源管理和缩短产品进入市场的时间,出现了针对晶圆级的系统级芯片(system on a chip简称SOC)和针对组件级的系统级组件(system on a pakage简称SOP).本文介绍了SOC和SOP的益处、功能和优点.

  6. Comment on "Attenuation and dispersion of sound in dilute suspensions of spherical particles" [J. Acoust. Soc. Am. 108(1), 126-146 (2000)].

    Science.gov (United States)

    Shukla, Shiva Kant; Elvira, Luis

    2015-05-01

    Comment is made on an article by Temkin [J. Acoust. Soc. Am. 108(1), 126-146 (2000)]. This work illustrates the impact of particle size distribution on the dispersion and attenuation of sound waves propagating through particle suspensions. Temkin's propagation theory is extended for poly-disperse distributions of spherical particles, applicable to real suspensions. Significant changes in dispersion and attenuation appear near the particle resonance for both bubble and solid particle suspensions. Existing experimental data for bubble distributions also shows a good agreement with the poly-disperse modifications proposed.

  7. SOC Balance Control Strategy of MMC Energy Storage Converter%基于MMC的储能系统SOC均衡控制

    Institute of Scientific and Technical Information of China (English)

    王帅; 荆龙; 吴学智; 赵新

    2016-01-01

    针对模块化多电平储能变流器(MMC-ES)中子模块电池荷电状态(SOC)均衡控制的问题,在此通过数学模型分析了MMC-ES桥臂电流组成成分,提出了SOC均衡控制策略.最后经过仿真与实验验证了上述理论分析的正确性以及控制策略的有效性.

  8. The sense of coherence (SOC) as an important determinant of life satisfaction, based on own research, and exemplified by the students of University of the Third Age (U3A).

    Science.gov (United States)

    Zielińska-Więczkowska, Halina; Ciemnoczołowski, Waldemar; Kędziora-Kornatowska, Kornelia; Muszalik, Marta

    2012-01-01

    The SOC is an important determinant of life satisfaction of elderly people. It determines the level of coping with various difficult situations, which accompany an old age stage. The aim of the study was to determine the connection between the SOC levels and life satisfaction among the U3A students. Another analyzed relationship was the SOC level against the background of socio-demographic factors. The study comprised 257 students of the U3A in Poland, located in the city of Bydgoszcz. The study group consisted of 237 women and 20 men, at the average age of 64.54 ± 6.01 years. The vast majority of the study group included individuals at the secondary education level, as well as married individuals. Just over half of the group claimed to be in good health, and have no afflictions. All of the respondents were fully mobile. The study was conducted with the diagnostic poll method, using the standardized questionnaires: The Scale SOC-29, WHOQOL-Bref, and the Geriatric Depression Scale (GDS-bref version). The average value of global SOC was 128.77; the standard deviation 21.04; discrepancy 153 (minimum 50 and maximum 203). The SOC indicated significant relationship with quality of life (QoL) in the mental domain, social relationships, and environmental domain; no significant correlation in the physical domain was observed. The QOL reached about 70% of maximum result value, showing equal levels in its specific areas. A moderately decreasing (r=-0.375, pSOC values and depression occurrence, as well as its non-existence was shown in the study. Individual SOC components were also negatively correlated with depression. Another observation was weak correlation between the sense of coherence and the individuals' level of education. No statistically significant effect of age, gender and marital status on the SOC levels of U3A students was found. Higher parameters of SOC and level of education shape significantly higher effects of life satisfaction, and result in better

  9. SOCS3基因敲除促进小鼠脊髓损伤处巨噬细胞向M2型分化%SOCS3 conditional ablation induces differentiation of M2-type macrophages after spinal cord injury in mice

    Institute of Scientific and Technical Information of China (English)

    党圆圆; 张洪钿; 籍新潮; 吴翠莹; 陈晨; 杨艺; 徐如祥

    2016-01-01

    目的 探讨条件性敲除细胞因子信号转导抑制蛋白3(SOCS3)基因后小鼠脊髓损伤处巨噬细胞表型变化及运动功能恢复情况. 方法 以神经系统条件性敲除SOCS3基因的基因工程小鼠(Socs3fVfl Nes cre)(实验组)及未敲除SOCS3基因的同窝小鼠(Socs3fl)(对照组)为研究对象,每组40只.2组小鼠分别各取35只对T10节段脊髓施以钳夹伤,另5只仅做假手术对照.每组分别取15只损伤模型小鼠在术后3、7、14d用于免疫荧光染色检测Arginase1(巨噬细胞M2a型、M2c型表型标志物)及CD86(巨噬细胞M1型、M2b型表型标志物)表达;每组分别取剩余20只损伤模型小鼠在术后1、3、7、14d用于荧光定量RT-PCR检测Arginase1、CD206(巨噬细胞M2型表型标志物)、诱导型一氧化氮合酶(iNOS)、CD32(巨噬细胞M1型表型标志物)及SOCS3、信号传导与转录激活因子3(STAT3)基因表达,并以假手术对照小鼠为基线;在术后1、3、7、14d采用BMS量表评价小鼠后肢及躯干运动功能. 结果 行为学实验结果显示:实验组小鼠BMS评分在术后3、7、14d明显高于对照组,差异均有统计学意义(P<0.05).对Iba1与CD86及Arginase1共染色细胞进行计数半定量分析发现:实验组中Iba1与Arginase1共染色阳性细胞在术后3、7、14d明显多于对照组,差异均有统计学意义(P<0.05);实验组中Iba1与CD86共染色阳性细胞在术后7、14d明显少于对照组,差异均有统计学意义(P<0.05).荧光定量PCR结果显示:术后1、3d,实验组SOCS3基因表达量较对照组明显减低,差异均有统计学意义(P<0.05).术后3、7、14d,实验组STA T3基因表达量较对照组明显增高,差异均有统计学意义(P<0.05).与对照组相比,术后7d实验组Arginase1及CD206基因表达量明显增加,差异均有统计学意义(P<0.05);与对照组相比,术后14d实验组CD206基因表达量明显增加,CD32基因表达量明显降低,差异均有统计学意义(P<0

  10. Sobre os céus e as marés do Pacífico: as observações astronômicas do jesuíta Nicolás Mascardi (Chile, século XVII

    Directory of Open Access Journals (Sweden)

    Eliane Cristina Deckmann Fleck

    2014-12-01

    Full Text Available A atuação da Companhia de Jesus na América espanhola e portuguesa constitui-se em tema de várias investigações e obras, nas quais merece destaque a dedicação de seus religiosos ao ensino e à catequese. Alguns membros da Ordem, no entanto, se dedicaram, também, a observações de fenômenos naturais, da fauna e da flora nativas e, ainda, a aspectos da geografia dos territórios em que atuaram, legando-nos uma série de estudos informados através de cartas, relatórios ou obras. Nosso propósito neste artigo é o de apresentar e analisar os registros que o padre jesuíta italiano Nicolás Mascardi fez de suas observações astronômicas e, em especial, do estudo que realizou sobre as marés do arquipélago de Chiloé durante os anos em que atuou na então Vice-Província Jesuítica do Chile, no século XVII.

  11. Multi-layered Regulation of SPL15 and Cooperation with SOC1 Integrate Endogenous Flowering Pathways at the Arabidopsis Shoot Meristem.

    Science.gov (United States)

    Hyun, Youbong; Richter, René; Vincent, Coral; Martinez-Gallegos, Rafael; Porri, Aimone; Coupland, George

    2016-05-09

    Flowering is initiated in response to environmental and internal cues that are integrated at the shoot apical meristem (SAM). We show that SPL15 coordinates the basal floral promotion pathways required for flowering of Arabidopsis in non-inductive environments. SPL15 directly activates transcription of the floral regulators FUL and miR172b in the SAM during floral induction, whereas its paralog SPL9 is expressed later on the flanks of the SAM. The capacity of SPL15 to promote flowering is regulated by age through miR156, which targets SPL15 mRNA, and gibberellin (GA), which releases SPL15 from DELLAs. Furthermore, SPL15 and the MADS-box protein SOC1 cooperate to promote transcription of their target genes. SPL15 recruits RNAPII and MED18, a Mediator complex component, in a GA-dependent manner, while SOC1 facilitates active chromatin formation with the histone demethylase REF6. Thus, we present a molecular basis for assimilation of flowering signals and transcriptional control at the SAM during flowering. Copyright © 2016 Elsevier Inc. All rights reserved.

  12. Annexin A1 released from apoptotic cells acts through formyl peptide receptors to dampen inflammatory monocyte activation via JAK/STAT/SOCS signalling

    Science.gov (United States)

    Pupjalis, Danute; Goetsch, Julia; Kottas, Diane J; Gerke, Volker; Rescher, Ursula

    2011-01-01

    The immunosuppressive effects of apoptotic cells involve inhibition of pro-inflammatory cytokine release and establishment of an anti-inflammatory cytokine profile, thus limiting the degree of inflammation and promoting resolution. We report here that this is in part mediated by the release of the anti-inflammatory mediator annexin A1 from apoptotic cells and the functional activation of annexin A1 receptors of the formyl peptide receptor (FPR) family on target cells. Supernatants from apoptotic neutrophils or the annexin A1 peptidomimetic Ac2-26 significantly reduced IL-6 signalling and the release of TNF-α from endotoxin-challenged monocytes. Ac2-26 activated STAT3 in a JAK-dependent manner, resulting in upregulated SOCS3 levels, and depletion of SOCS3 reversed the Ac2-26-mediated inhibition of IL-6 signalling. This identifies annexin A1 as part of the anti-inflammatory pattern of apoptotic cells and links the activation of FPRs to established signalling pathways triggering anti-inflammatory responses. PMID:21254404

  13. HCV-induced miR146a controls SOCS1/STAT3 and cytokine expression in monocytes to promote regulatory T-cell development.

    Science.gov (United States)

    Ren, J P; Ying, R S; Cheng, Y Q; Wang, L; El Gazzar, M; Li, G Y; Ning, S B; Moorman, J P; Yao, Z Q

    2016-10-01

    Host innate and adaptive immune responses must be tightly regulated by an intricate balance between positive and negative signals to ensure their appropriate onset and termination while fighting pathogens and avoiding autoimmunity; persistent pathogens may usurp these regulatory machineries to dampen host immune responses for their persistence in vivo. Here, we demonstrate that miR146a is up-regulated in monocytes from hepatitis C virus (HCV)-infected individuals compared to control subjects. Interestingly, miR146a expression in monocytes without HCV infection increased, whereas its level in monocytes with HCV infection decreased, following Toll-like receptor (TLR) stimulation. This miR146a induction by HCV infection and differential response to TLR stimulation were recapitulated in vitro in monocytes co-cultured with hepatocytes with or without HCV infection. Importantly, inhibition of miR146a in monocytes from HCV-infected patients led to a decrease in IL-23, IL-10 and TGF-β expressions through the induction of suppressor of cytokine signalling 1 (SOCS1) and the inhibition of signal transducer and activator transcription 3 (STAT3), and this subsequently resulted in a decrease in regulatory T cells (Tregs) accumulated during HCV infection. These results suggest that miR146a may regulate SOCS1/STAT3 and cytokine signalling in monocytes, directing T-cell differentiation and balancing immune clearance and immune injury during chronic viral infection.

  14. SEMICONDUCTOR INTEGRATED CIRCUITS A 10-bit 200-kS/s SAR ADC IP core for a touch screen SoC

    Science.gov (United States)

    Xingyuan, Tong; Yintang, Yang; Zhangming, Zhu; Wenfang, Sheng

    2010-10-01

    Based on a 5 MSBs (most-significant-bits)-plus-5 LSBs (least-significant-bits) C-R hybrid D/A conversion and low-offset pseudo-differential comparison approach, with capacitor array axially symmetric layout topology and resistor string low gradient mismatch placement method, an 8-channel 10-bit 200-kS/s SAR ADC (successive-approximation-register analog-to-digital converter) IP core for a touch screen SoC (system-on-chip) is implemented in a 0.18 μm 1P5M CMOS logic process. Design considerations for the touch screen SAR ADC are included. With a 1.8 V power supply, the DNL (differential non-linearity) and INL (integral non-linearity) of this converter are measured to be about 0.32 LSB and 0.81 LSB respectively. With an input frequency of 91 kHz at 200-kS/s sampling rate, the spurious-free dynamic range and effective-number-of-bits are measured to be 63.2 dB and 9.15 bits respectively, and the power is about 136 μW. This converter occupies an area of about 0.08 mm2. The design results show that it is very suitable for touch screen SoC applications.

  15. SEMICONDUCTOR INTEGRATED CIRCUITS: A fully integrated UHF RFID reader SoC for handheld applications in the 0.18 μm CMOS process

    Science.gov (United States)

    Jingchao, Wang; Chun, Zhang; Zhihua, Wang

    2010-08-01

    A low cost fully integrated single-chip UHF radio frequency identification (RFID) reader SoC for short distance handheld applications is presented. The SoC integrates all building blocks—including an RF transceiver, a PLL frequency synthesizer, a digital baseband and an MCU—in a 0.18 μm CMOS process. A high-linearity RX front-end is designed to handle the large self-interferer. A class-E power amplifier with high power efficiency is also integrated to fulfill the function of a UHF passive RFID reader. The measured maximum output power of the transmitter is 20.28 dBm and the measured receiver sensitivity is -60 dBm. The digital baseband including MCU core consumes 3.91 mW with a clock of 10 MHz and the analog part including power amplifier consumes 368.4 mW. The chip has a die area of 5.1 × 3.8 mm2 including pads.

  16. Long-term fasting in the anadromous Arctic charr is associated with downregulation of metabolic enzyme activity and upregulation of leptin A1 and SOCS expression in the liver.

    Science.gov (United States)

    Jørgensen, Even Hjalmar; Martinsen, Mads; Strøm, Vidar; Hansen, Kristin Elisa Ruud; Ravuri, Chandra Sekhar; Gong, Ningping; Jobling, Malcolm

    2013-09-01

    The life strategy of the anadromous Arctic charr (Salvelinus alpinus) includes several months of voluntary fasting during overwintering in freshwater, leading to emaciation prior to seawater migration in spring. In this study we compared changes in condition, substrate utilization and liver metabolism between captive anadromous charr subjected to food deprivation during late winter and spring, and conspecifics fed in excess. In March, nine out of the 10 sampled fed fish had not eaten, indicating that they were in a voluntary anorexic state. In June, the fed fish were eating and all had higher body mass, condition factor and adiposity than in March. In fasted fish there were only small decreases in body mass, condition factor and adiposity between March and May, but all these parameters decreased markedly from May to June. The fasted fish were depleted in fat and glycogen in June, had suppressed activity of hepatic enzymes involved in lipid metabolism (G6PDH and HOAD) and seemed to rely on protein-derived glucose as a major energy source. This was associated with upregulated liver gene expression of leptin A1, leptin A2, SOCS1, SOCS2 and SOCS3, and reduced IGF-I expression. In an in vitro study with liver slices it was shown that recombinant rainbow trout leptin stimulated SOCS1 and SOCS3 expression, but not SOCS2, IGF-I or genes of enzymes involved in lipid (G6PDH) and amino acid (AspAT) metabolism. It is concluded that liver leptin interacts with SOCS in a paracrine fashion to suppress lipolytic pathways and depress metabolism when fat stores are depleted.

  17. SOCS3 and IRS-1 gene expression differs between genotype 1 and genotype 2 hepatitis C virus-infected HepG2 cells.

    Science.gov (United States)

    Persico, Marcello; Russo, Roberta; Persico, Eliana; Svelto, Monica; Spano, Daniela; Andolfo, Immacolata; La Mura, Vincenzo; Capasso, Mario; Tiribelli, Claudio; Torella, Roberto; Iolascon, Achille

    2009-01-01

    The poor response to antiviral treatment of hepatitis C virus (HCV)-infected patients with genotype 1b has been associated with a higher prevalence of metabolic syndrome. However, the molecular link between these clinical entities is not clear. The goal of this study was to clarify the role of genotype 1b and 2 in the genetic expression of suppressor of cytokine signaling 3 (SOCS3) and insulin receptor substrate 1 (IRS-1). We infected human hepatocellular carcinoma cell line (HepG2) cells with human HCV genotype 1b or 2 and measured the gene and protein expression of SOCS3 at various times. We also evaluated impairment in the insulin pathway by analysis of IRS-1 and phospho-AKT. For the control, we used HepG2 cell cultures treated with non-infectious serum. We also demonstrated the occurrence of HCV infection by the detection of both positive and negative strands in the cells and culture medium. To test infection of the HepG2 cells, we performed quantitative real-time polymerase chain reaction (qRT-PCR) of viral load at different time points. We analyzed the viral genotype in the pellet and supernatant. At each time point, we found positive and negative strands in the infected cells, while in the medium we found positive, but no negative strands. We also detected the presence of the correct genotype in the medium. Two weeks following infection when the viral load was higher, we tested genotype 1b and 2 infected cells. SOCS3 gene expression was significantly higher in genotype 1b-infected cells (median 2.56; mean 2.82+/-0.59) compared with genotype 2 (median 1.34; mean 1.46+/-0.31) (p=0.04) and control cells (median 1.09; mean 1.02+/-0.11, p=0.02). There was no difference between cells exposed to genotype 2 and control cells. Conversely, IRS-1 was significantly lower in genotype 1b-infected cells (median 15.97; mean 15.45+/-0.67) compared with genotype 2-infected cells (median 16.45; mean 16.44+/-0.01, p=0.04). Statistically significant differences were seen when

  18. Effects of Shenshuai Yangzhen Capsule on SOCS-3 in Hapotholums in Malnutrition Rats with Chronic Renal Failure by 5/6 Nephrectomy%肾衰养真胶囊对5/6肾切慢性肾衰竭营养不良大鼠下丘脑信号传导蛋白SOCS-3表达的影响

    Institute of Scientific and Technical Information of China (English)

    李玉明; 魏连波; 邓聪

    2007-01-01

    目的 探讨细胞因子信号传导抑制剂-3(SOCS-3)在慢性肾衰竭营养不良大鼠中的表达情况以及肾衰养真胶囊的调节作用.方法 5/6肾切除制作慢性肾衰竭大鼠模型,同时予4%酪蛋白饮食,检测血尿素氮、肌酐、白蛋白、血红蛋白等生化指标和体重,观察其营养不良发生时间,符合条件的随机分为模型组、肾衰养真胶囊治疗组和开同治疗组;另设正常对照组.灌胃4周后应用放射免疫法检测血瘦素水平,免疫组织化学方法检测下丘脑SOCS-3蛋白的表达.结果 慢性肾衰竭大鼠在术后10周末出现营养不良,肾衰养真胶囊可减低血浆尿素氮、肌酐、瘦素水平,增加白蛋白、血红蛋白水平;与正常组比较,模型组与肾衰养真胶囊治疗组SOCS-3当色阳性信号均强(P<0.001),但肾衰养真胶囊组SOCS-3染色阳性信号显著高于模型组(P<0.05).结论 肾衰养真胶囊可能部分是通过上调抑制蛋白SOCS-3,降低瘦素水平,从而改善慢性肾衰竭大鼠营养不良.

  19. IL-1β, IL-6 levels and SOCS-3 gene expression in hypothalamus of BALB/c mice with brain asymmetry%脑不对称BALB/c小鼠下丘脑IL-1β、IL-6水平和SOCS-3基因表达

    Institute of Scientific and Technical Information of China (English)

    苏芸; 赵丽纯; 李康生

    2005-01-01

    目的:研究脑不对称性对下丘脑中IL-1β、IL-6及细胞因子信号转导抑制因子-3(SOCS-3)表达的影响,从分子水平探讨脑不对称性在神经内分泌免疫调节网络中的作用.方法:运用伸爪取食法将BALB/c小鼠区分为左利、右利和双利鼠.小鼠分组一周后断头杀死,迅速分离出下丘脑,一部分标本制备匀浆后采用ELISA法测定下丘脑中IL-1β、IL-6的蛋白水平;另一部分标本以RT-PCR法间接测定下丘脑SOCS-3 mRNA水平.结果:(1)下丘脑IL-6蛋白水平:左利鼠水平明显高于右利鼠,差异有统计学意义(P<0.05).(2)下丘脑IL-1β蛋白水平:左利、右利小鼠水平相近,差异无显著性(P>0.05).(3)下丘脑SOCS-3表达:右利鼠下丘脑中SOCS-3的表达显著高于左利鼠(P<0.05).结论:脑不对称BALB/c小鼠下丘脑IL-1β、IL-6及细胞因子信号转导抑制因子SOCS-3的表达存在差异,提示这可能是左、右利人群免疫紊乱性疾病发生率不同原因之一.

  20. Orai1 and Ca2+-independent phospholipase A2 are required for store-operated Icat-SOC current, Ca2+ entry, and proliferation of primary vascular smooth muscle cells.

    Science.gov (United States)

    Yang, Bo; Gwozdz, Tomasz; Dutko-Gwozdz, Joanna; Bolotina, Victoria M

    2012-03-01

    Store-operated Ca(2+) entry (SOCE) is important for multiple functions of vascular smooth muscle cells (SMC), which, depending of their phenotype, can resemble excitable and nonexcitable cells. Similar to nonexcitable cells, Orai1 was found to mediate Ca(2+)-selective (CRAC-like) current and SOCE in dedifferentiated cultured SMC and smooth muscle-derived cell lines. However, the role of Orai1 in cation-selective store-operated channels (cat-SOC), which are responsible for SOCE in primary SMC, remains unclear. Here we focus on primary SMC, and assess the role of Orai1 and Ca(2+)-independent phospholipase A(2) (iPLA(2)β, or PLA2G6) in activation of cat-SOC current (I(cat-SOC)), SOCE, and SMC proliferation. Using molecular, electrophysiological, imaging, and functional approaches, we demonstrate that molecular knockdown of either Orai1 or iPLA(2)β leads to similar inhibition of the whole cell cat-SOC current and SOCE in primary aortic SMC and results in significant reduction in DNA synthesis and impairment of SMC proliferation. This is the first demonstration that Orai1 and iPLA(2)β are equally important for cat-SOC, SOCE, and proliferation of primary aortic SMC.

  1. 充电SOC对磷酸铁锂电池寿命的影响对磷酸铁锂电池寿命的影响充电SOC

    Institute of Scientific and Technical Information of China (English)

    孙庆; 吴战宇; 沙树勇; 周寿斌

    2015-01-01

    考察不同充电SOC(荷电状态State of Charge的缩写)下的磷酸铁锂电池循环性能.实验结果表明:磷酸铁锂电池的循环寿命与SOC的变化规律与预期一致,均是随之着SOC的降低,循环寿命显著提升;如将100%SOC下的循环寿命定为1,则90%SOC为1.42,80%SOC为2.98,60%SOC为6.62,50%SOC为12.28,30%SOC为19.44;100%~30%SOC的相对寿命变化率可分为4个阶段,1阶段:100%~90%SOC,变化斜率0.42;2阶段:90%~60%SOC,变化斜率为1.56;3阶段:60%~50%SOC,变化斜率为5.66;4阶段:50%~30%SOC,变化斜率为3.58.

  2. SOC中Data-Path布图设计面临的挑战%Challenges to Data-Path Physical Design Inside SOC

    Institute of Scientific and Technical Information of China (English)

    经彤; 洪先龙; 蔡懿慈; 许静宇; 杨长旗; 张轶谦; 周强; 吴为民

    2002-01-01

    目前所设计的系统级芯片(SOC)包含有多个data-path模块,这使得data-path成为整个G大规模集成电路(GSI)设计中最关键的部分.以往的布图理论及算法在许多方面已不能满足data-path布图设计的需要,这主要是由于传统的布图工具没有考虑data-path所特有的电路结构特点.Data-path具有规整的位片结构,具有很高的性能指标要求,如对于时延、耦合效应和串扰等性能都有严格的要求.此外,data-path中还存在大量成束状结构的BUS线网.文中提出了data-path布图设计所面临的挑战.从介绍data-path布图的基本问题入手,重点分析了data-path布图设计中的关键技术,并在讨论已有研究工作的基础上针对不同的布图阶段提出了可行的技术路线与设想.%Previously,a single data-path stack was adequate for data-path chips,and the complexity and size of the data-path was comparatively small.As current data-path chips,such as system-on-a-chip (SOC),become more complex,multiple data-path stacks are required to implement the entire data-path.As more data-path stacks are integrated into SOC,data-path is becoming a critical part of the whole giga-scale integrated circuits (GSI) design.The traditional physical design methodology can not satisfy the data-path performance requirements,because it can not accommodate the data-path bit-sliced structure and the strict performance (such as timing,coupling,and crosstalk) constraints.Challenges in the data-path physical design are addressed.The fundamental problems and key technologies in data-path physical design are analysed.The corresponding researches and solutions in this research field are also discussed.

  3. Overexpression of an Orchid (Dendrobium nobile) SOC1/TM3-Like Ortholog, DnAGL19, in Arabidopsis Regulates HOS1-FT Expression.

    Science.gov (United States)

    Liu, Xiao-Ru; Pan, Ting; Liang, Wei-Qi; Gao, Lan; Wang, Xiao-Jing; Li, Hong-Qing; Liang, Shan

    2016-01-01

    Flowering in the appropriate season is critical for successful reproduction in angiosperms. The orchid species, Dendrobium nobile, requires vernalization to achieve flowering in the spring, but the underlying regulatory network has not been identified to date. The MADS-box transcription factor DnAGL19 was previously identified in a study of low-temperature treated D. nobile buds and was suggested to regulate vernalization-induced flowering. In this study, phylogenetic analysis of DnAGL9 and the MADS-box containing proteins showed that DnAGL19 is phylogenetically closely related to the SOC1-like protein from orchid Dendrobium Chao Parya Smile, DOSOC1. The orchid clade closed to but is not included into the SOC1-1/TM3 clades associated with either eudicots or monocots, suggesting that DnAGL19 is an SOC1-1/TM3-like ortholog. DnAGL19 was found to be highly expressed in pseudobulbs, leaves, roots, and axillary buds but rarely in flowers, and to be substantially upregulated in axillary buds by prolonged low-temperature treatments. Overexpression of DnAGL19 in Arabidopsis thaliana resulted in a small but significantly reduced time to bolting, suggesting that flowering time was slightly accelerated under normal growth conditions. Consistent with this, the A. thaliana APETELA1 (AP1) gene was expressed at an earlier stage in transgenic lines than in wild type plants, while the FLOWERING LOCUS T (FT) gene was suppressed, suggesting that altered regulations on these transcription factors caused the weak promotion of flowering. HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENE 1 (HOS1) was slightly activated under the same conditions, suggesting that the HOS1-FT module may be involved in the DnAGL19-related network. Under vernalization conditions, FT expression was significantly upregulated, whereas HOS1 expression in the transgenic A. thaliana has a level similar to that in wild type. Taken together, these results suggest that DnAGL19 controls the action of the HOS1-FT module

  4. Overexpression of an orchid (Dendrobium nobile SOC1/TM3-like ortholog, DnAGL19, in Arabidopsis regulates HOS1-FT expression

    Directory of Open Access Journals (Sweden)

    Xiao-ru eLiu

    2016-02-01

    Full Text Available Flowering in the appropriate season is critical for successful reproduction in angiosperms. The orchid species, Dendrobium nobile, requires vernalization to achieve flowering in the spring, but the underlying regulatory network has not been identified to date. The MADS-box transcription factor DnAGL19 was previously identified in a study of low-temperature treated D. nobile buds and was suggested to regulate vernalization-induced flowering. In this study, phylogenetic analysis of DnAGL9 and the MADS-box containing proteins showed that DnAGL19 is phylogenetically closely related to the SOC1-like protein from orchid Dendrobium Chao Parya Smile, DOSOC1. The orchid clade closed to but is not included into the SOC1-1/TM3 clades associated with either eudicots or monocots, suggesting that DnAGL19 is an SOC1-1/TM3-like ortholog. DnAGL19 was found to be highly expressed in pseudobulbs, leaves, roots and axillary buds but rarely in flowers, and to be substantially upregulated in axillary buds by prolonged low-temperature treatments. Overexpression of DnAGL19 in Arabidopsis thaliana resulted in a small but significantly reduced time to bolting, suggesting that flowering time was slightly accelerated under normal growth conditions. Consistent with this, the A. thaliana APETELA1 (AP1 gene was expressed at an earlier stage in transgenic lines than in wild type plants, while the FLOWERING LOCUS T (FT gene was suppressed, suggesting that altered regulations on these transcription factors caused the weak promotion of flowering. HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENE 1 (HOS1 was slightly activated under the same conditions, suggesting that the HOS1-FT module may be involved in the DnAGL19-related network. Under vernalization conditions, FT expression was significantly upregulated, whereas HOS1 expression in the transgenic A. thaliana has a level similar to that in wild type. Taken together, these results suggest that DnAGL19 controls the action of the

  5. Understanding Hydrogen Sorption in In- soc -MOF: A Charged Metal-Organic Framework with Open-Metal Sites, Narrow Channels, and Counterions

    KAUST Repository

    Pham, Tony

    2015-03-04

    © 2015 American Chemical Society. Grand canonical Monte Carlo (GCMC) simulations of hydrogen sorption were performed in In-soc-MOF, a charged metal-organic framework (MOF) that contains In3O trimers coordinated to 5,5′-azobis(1,3-benzenedicarboxylate) linkers. The MOF contains nitrate counterions that are located in carcerand-like capsules of the framework. This MOF was shown to have a high hydrogen uptake at 77 K and 1.0 atm. The simulations were performed with a potential that includes explicit many-body polarization interactions, which were important for modeling gas sorption in a charged/polar MOF such as In-soc-MOF. The simulated hydrogen sorption isotherms were in good agreement with experiment in this challenging platform for modeling. The simulations predict a high initial isosteric heat of adsorption, Qst, value of about 8.5 kJ mol-1, which is in contrast to the experimental value of 6.5 kJ mol-1 for all loadings. The difference in the Qst behavior between experiment and simulation is attributed to the fact that, in experimental measurements, the sorbate molecules cannot access the isolated cages containing the nitrate ions, the most energetically favorable site in the MOF, at low pressures due to an observed diffusion barrier. In contrast, the simulations were able to capture the sorption of hydrogen onto the nitrate ions at low loading due to the equilibrium nature of GCMC simulations. The experimental Qst values were reproduced in simulation by blocking access to all of the nitrate ions in the MOF. Furthermore, at 77 K, the sorbed hydrogen molecules were reminiscent of a dense fluid in In-soc-MOF starting at approximately 5.0 atm, and this was verified by monitoring the isothermal compressibility, βT, values. The favorable sites for hydrogen sorption were identified from the polarization distribution as the nitrate ions, the In3O trimers, and the azobenzene

  6. The expression change and anti-immune injury effects of SOCS-1 during endotoxin-induced acute liver injury in mice%SOCS-1在小鼠内毒素急性肝损伤的表达变化及其抗免疫损伤作用

    Institute of Scientific and Technical Information of China (English)

    马毅; 胡斌; 黄凯军; 汪荣; 程东辉

    2013-01-01

    Objective To observe the expression change of suppressors of cytokine signaling-1 (SOCS-1) in acute lver injury (ALI) induced by endotoxin-lipopolysaccharide (LPS),and investigate the probable mechanism of SOCS-1 regulating immune inflammatory injury in the liver.Methods Seventytwo male BALB/c mice were randomized into 3 groups (n =24 each).Group A,ALI group:D-galactosamine (D-GaIN) was dissolved in 0.9% aseptic sodium chloride injection.Mter adjusting the pH to 7.0 with sodium hydroxide,the mixture was injected intraperitoneally with LPS.The dosage of D-GaIN and LPS was 0.02 μg/kg and 4.00 μg/kg,respectively; Group B,endotoxin tolerance group (ETF group):LPS was dissolved in 0.9% aseptic sodium chloride injection.Intraperitoneal injection was then performed at the low dose of 0.002 μg/kg,once daily for 5 days.Intraperitoneal injection of D-GaIN/LPS was performed 24 h after the fifth injection of LPS.All the processes and dosages were similar to ALI group; Group C,control group:only intraperitoneal injection of 0.2 ml 0.9% aseptic sodium chloride injection was performed.Blood and liver specimens were obtained from mice in all groups at 6,12 and 24 h after the injection of D-GaIN/LPS or 0.9% aseptic sodium chloride.The pathological changes of the liver were observed and the expression of SOCS-1 mRNA and protein in the liver of mice as well as serum tumor necrosis factor-α(TNF-α),alanine aminotransferase (ALT) and total bilirubin (TBiL) levels were detected.Results Large area of liver cell degeneration,necrosis and numerous inflammation cell infiltration were found in portal area in ALI group.SOCS-1 mRNA and protein expression in the liver of mice was increased significantly in ALI group,as compared with control group 6 h after modeling,and reached the peak at 12 h (P < 0.05).Pathological changes in the liver were significantly milder in ETI group than in ALI group.Serum TNF-α,ALT and TBiL levels were significantly lower in ETI group than in ALI group

  7. 糖基化终末产物(AGEs)诱导下SOCS基因在肾小管上皮细胞中的表达及意义%EXPRESSION OF SOCS GENE IN RENAL TUBULAR CELLS INDUCED BY ADVANCED GLYCATION END PRODUCTS(AGEs)

    Institute of Scientific and Technical Information of China (English)

    王晨; 史永红; 郝军; 戎赞华; 段惠军

    2008-01-01

    目的 观察SOCS-1、SOCS-3在肾小管上皮细胞(HKC)中的基础表达及在糖基化终末产物(AGEs)诱导下的表达及意义.方法 体外培养HKC细胞,随机分为正常对照组、AGEs组,倒置显微镜观察细胞形态学改变,采用流式细胞术,免疫细胞化学和检测SOCS-1、SOCS-3蛋白表达,RT-PCR法检测HKC SOCS-1、SOCS-3 mRNA表达.结果 与正常组比较,AGES诱导的肾小管上皮细胞发生形态学改变;免疫细胞化学、流式细胞学发现SOCS-1、SOCS-3表达以胞浆为主,散在胞核表达;12、24、48h SOCS-1、SOCS-3蛋白表达AGEs组均高于正常对照组,差异有统计学意义,其中SOCS-1以12h表达量最大,SOCS-3以24h表达最高,RT-PCR检测SOCS-3 mRNA表达最,AGEs组高于正常组,差异有统计学意义.结论 SOCS-1、SOCS-3在正常肾小管上皮细胞中有基础表达,AGEs可诱导肾小管上皮细胞SOCS-1、SOCS-3表达上调,为我们进一步研究SOCS基因与糖尿病肾病的关系提供了理论依据.

  8. Reusable AVS decoder SOC architecture design based on software-hardware co-design%可重用AVS芯片结构软硬件协同设计

    Institute of Scientific and Technical Information of China (English)

    王忠平; 祝永新; 郭炜

    2008-01-01

    根据软硬件设计思想设计一个结构划分合理的可重用的AVS视频解码器结构.通过ARM平台软件移植,然后使用ARM ESL工具对系统模块性能进行整体评估,然后根据评估结果以及硬件实现复杂度进行软硬件结构的划分,定制软硬件模块接口,从硬件扩展考虑把硬件部分设计为与H.264解码器兼容并用SystemC模拟,最后在SOC Designer 平台做协同验证及仿真.

  9. Modeling and estimation study on 18650 power battery SOC%18650动力电池SOC的建模与估算研究

    Institute of Scientific and Technical Information of China (English)

    王增红; 潘勇; 李旭军; 雷维新; 潘俊安

    2014-01-01

    为了实现对18650动力电池荷电状态(SOC)的准确在线估算,将外界条件划分为12种情况,研究了有效电量、电池衰老及环境温度对电池SOC的影响.建立了一个BP神经网络模型,在12种条件下对其进行样本学习训练,建立了一种能够适用于不同条件下的基于条件查找方法的SOC估算模型.通过与传统方法对比,证明改进的估算方法具有更好的精度和实用性.

  10. Dynamic Voltage-Frequency and Workload Joint Scaling Power Management for Energy Harvesting Multi-Core WSN Node SoC

    Science.gov (United States)

    Li, Xiangyu; Xie, Nijie; Tian, Xinyue

    2017-01-01

    This paper proposes a scheduling and power management solution for energy harvesting heterogeneous multi-core WSN node SoC such that the system continues to operate perennially and uses the harvested energy efficiently. The solution consists of a heterogeneous multi-core system oriented task scheduling algorithm and a low-complexity dynamic workload scaling and configuration optimization algorithm suitable for light-weight platforms. Moreover, considering the power consumption of most WSN applications have the characteristic of data dependent behavior, we introduce branches handling mechanism into the solution as well. The experimental result shows that the proposed algorithm can operate in real-time on a lightweight embedded processor (MSP430), and that it can make a system do more valuable works and make more than 99.9% use of the power budget. PMID:28208730

  11. Noise and Spurious Tones Management Techniques for Multi-GHz RF-CMOS Frequency Synthesizers Operating in Large Mixed Analog-Digital SOCs

    Directory of Open Access Journals (Sweden)

    Maxim Adrian

    2006-01-01

    Full Text Available This paper presents circuit techniques and power supply partitioning, filtering, and regulation methods aimed at reducing the phase noise and spurious tones in frequency synthesizers operating in large mixed analog-digital system-on-chip (SOC. The different noise and spur coupling mechanisms are presented together with solutions to minimize their impact on the overall PLL phase noise performance. Challenges specific to deep-submicron CMOS integration of multi-GHz PLLs are revealed, while new architectures that address these issues are presented. Layout techniques that help reducing the parasitic noise and spur coupling between digital and analog blocks are described. Combining system-level and circuit-level low noise design methods, low phase noise frequency synthesizers were achieved which are compatible with the demanding nowadays wireless communication standards.

  12. Dynamic Voltage-Frequency and Workload Joint Scaling Power Management for Energy Harvesting Multi-Core WSN Node SoC

    Directory of Open Access Journals (Sweden)

    Xiangyu Li

    2017-02-01

    Full Text Available This paper proposes a scheduling and power management solution for energy harvesting heterogeneous multi-core WSN node SoC such that the system continues to operate perennially and uses the harvested energy efficiently. The solution consists of a heterogeneous multi-core system oriented task scheduling algorithm and a low-complexity dynamic workload scaling and configuration optimization algorithm suitable for light-weight platforms. Moreover, considering the power consumption of most WSN applications have the characteristic of data dependent behavior, we introduce branches handling mechanism into the solution as well. The experimental result shows that the proposed algorithm can operate in real-time on a lightweight embedded processor (MSP430, and that it can make a system do more valuable works and make more than 99.9% use of the power budget.

  13. The ZYNQ book embedded processing with the ARM Cortex-A9 on the Xilinx Zynq-7000 all programmable SoC

    CERN Document Server

    Crockett, Louise H; Enderwitz, Martin A; Stewart, Robert W

    2014-01-01

    This book is about the Zynq-7000 All Programmable System on Chip, the family of devices from Xilinx that combines an application-grade ARM Cortex-A9 processor with traditional FPGA logic fabric. Catering for both new and experienced readers, it covers fundamental issues in an accessible way, starting with a clear overview of the device architecture, and an introduction to the design tools and processes for developing a Zynq SoC. Later chapters progress to more advanced topics such as embedded systems development, IP block design and operating systems. Maintaining a 'real-world' perspective, the book also compares Zynq with other device alternatives, and considers end-user applications. The Zynq Book is accompanied by a set of practical tutorials hosted on a companion website. These tutorials will guide the reader through first steps with Zynq, following on to a complete, audio-based embedded systems design.

  14. Comment on "Reconstructing surface wave profiles from reflected acoustic pulses" [J. Acoust. Soc. Am. 133(5), 2597-2611 (2013)].

    Science.gov (United States)

    Choo, Youngmin; Song, H C

    2016-05-01

    A computationally efficient, time-domain Helmholtz-Kirchhoff (H-K) integral was derived and applied to reconstructing surface wave profiles from reflected acoustic pulses [Walstead and Deane, J. Acoust. Soc. Am. 133, 2597-2611 (2013)]. However, the final form of the integral equation incorporating a stationary phase approximation contained a complex phase term exp(iπ/4), which cannot be treated as a simple time delay. In this work, a real time-domain H-K integral is presented that includes an additional Hilbert transform of the time-derivative of the transmitted pulse. Numerical simulation with a sinusoidal surface shows good agreement between the real time-domain formulation and exact H-K integral, while achieving a significant improvement in computational speed (e.g., 2 orders of magnitude).

  15. Dynamic Voltage-Frequency and Workload Joint Scaling Power Management for Energy Harvesting Multi-Core WSN Node SoC.

    Science.gov (United States)

    Li, Xiangyu; Xie, Nijie; Tian, Xinyue

    2017-02-08

    This paper proposes a scheduling and power management solution for energy harvesting heterogeneous multi-core WSN node SoC such that the system continues to operate perennially and uses the harvested energy efficiently. The solution consists of a heterogeneous multi-core system oriented task scheduling algorithm and a low-complexity dynamic workload scaling and configuration optimization algorithm suitable for light-weight platforms. Moreover, considering the power consumption of most WSN applications have the characteristic of data dependent behavior, we introduce branches handling mechanism into the solution as well. The experimental result shows that the proposed algorithm can operate in real-time on a lightweight embedded processor (MSP430), and that it can make a system do more valuable works and make more than 99.9% use of the power budget.

  16. Note: Wide-range and high-resolution on-chip delay measurement circuit with low supply-voltage sensitivity for SoC applications

    Science.gov (United States)

    Sheng, Duo; Hung, Yu-Chan

    2016-11-01

    This paper presents an on-chip delay measurement (OCDM) circuit with a wide delay-measurement range, a high delay-measurement resolution and low supply-voltage sensitivity for efficient detection, and diagnosis in the high-performance system-on-chip (SoC). The proposed cascade-stage measurement structure can simultaneously achieve a delay-measurement range of several nanoseconds and a quantization resolution of several picoseconds. The proposed delay-measurement circuit has a high immunity to supply voltage variations without any additional calibration or self-biasing circuit. The delay-measurement range is 5.25 ns with 6 ps resolution; and the average delay resolution variation is 0.41% with ±10% supply voltage variations.

  17. Comment on "Relative variance of the mean squared pressure in multimode media: rehabilitating former approaches" [J. Acoust. Soc. Am. 136, 2621-2629 (2014)].

    Science.gov (United States)

    Davy, John L; Weaver, Richard L

    2015-03-01

    Models for the statistics of responses in finite reverberant structures, and in particular, for the variance of the mean square pressure in reverberation rooms, have been studied for decades. It is therefore surprising that a recent communication has claimed that the literature has gotten the simplest of such calculations very wrong. Monsef, Cozza, Rodrigues, Cellard, and Durocher [(2014). J. Acoust. Soc. Am. 136, 2621-2629] have derived a modal-based expression for the relative variance that differs significantly from expressions that have been accepted since 1969. This Comment points out that the Monsef formula is clearly incorrect, and then for the interested reader, points out the subtle place where they made their mistake.

  18. Comment on "Transient response of an acoustic medium by an excited submerged spherical shell" [J. Acoust. Soc. Am. 109(6), 2789-2796 (2001)].

    Science.gov (United States)

    Bahari, Ako; Popplewell, Neil

    2015-05-01

    A closed form solution was derived previously for the response of a submerged spherical shell when the shell was excited by a spatially distributed, transient load at its inner surface [Zakout (2001). J. Acoust. Soc. Am. 109(6), 2789-2796]. Numerical results were presented for the modal and total acoustic pressures outside the empty sphere when the load's temporal history corresponded to the Heaviside step function. However, the result presented for the shell's "breathing" mode was inconsistent with these data as it corresponded to the delta Dirac (impulse) function. Furthermore, numerical results, which were given later for the total acoustic pressure responses, did not involve either of these excitations. Consequently the present objective is to rectify these anomalies.

  19. Abnormal B-cell activation associated with TALL-1 over-expression and SOCS-1 suppression during chronic hepatitis C virus infection.

    Science.gov (United States)

    Moorman, Jonathan; Dong, Zhi P; Ni, Lei; Zhang, Chunlan; Borthwick, Thomas; Yao, Zhi Q

    2009-10-01

    Chronic hepatitis C virus (HCV) infection is associated with cirrhosis, autoimmunity and lymphoproliferative disorders. We have previously reported a differential regulation of T and B lymphocytes by HCV core protein in vitro. In this report, we employed a translational approach to characterize the activation status of peripheral B cells from individuals with chronic HCV infection and to explore potential mechanisms for B-cell dysregulation in the setting of HCV infection. In contrast to the T-cell suppression observed in HCV-infected individuals, B cells exhibit a non-specific polyclonal activation phenotype, characterized by significantly higher levels of (1) the early activation marker, CD69, (2) the costimulatory molecule, CD86, and (3) the CCR5 chemokine receptor, CD195, when compared with B cells from healthy donors in response to phytohaemagglutinin (PHA) stimulation. Importantly, tumour necrosis factor- and Apo-L-related leucocyte-expressed ligand-1 (TALL-1), also known as B-lymphocyte stimulator (BLYS), was found to be up-regulated on the surface of B cells from HCV patients in response to PHA as well as HCV core antigen stimulation. This up-regulation of TALL-1 was associated with vigorous memory B-cell responses to viral antigenic stimulation. Additionally, suppressor of cytokine signalling-1 (SOCS-1), a negative feedback immunoregulator that is inhibited in B lymphocytes by HCV core in vitro, was also inhibited in B cells from HCV patients when compared with healthy donors. These findings suggest that TALL-1 over-expression and SOCS-1 suppression are associated with aberrant B-cell activation, providing a plausible basis for the B-cell clonal expansion underlying the lymphoproliferative disorders and autoimmune phenomena observed during chronic HCV infection.

  20. 基于IEEE Std 1500标准的SOC可测性设计研究%Research of DFT of SOC based on IEEE Std 1500

    Institute of Scientific and Technical Information of China (English)

    周银; 周浔; 陈圣俭; 王月芳

    2012-01-01

    he technology of IP core based on SOC design is widely used, which is attribute to the rapid development of deep submicron meter manufacture technology and design technology of integrated circuit. Because of the fact that IP cores usually come from different providers and the incompatibility of interface between IP core providers and core users and aims at improving ease of test reuse and test integration with respect to the core based SOC. 1500 standard for embedded core test is presented to solve this problem. The detail includes the test architecture, usage of this standard and core test description language.%集成电路深亚微米制造技术和设计技术的迅速发展,使得基于IP核复用的SOC设计技术得到越来越广泛的应用,但由于IP核的来源不同,设计标准的不兼容等因素,使得SOC的测试变得越来越困难;IEEE为解决SOC的测试问题提出了嵌入式芯核测试标准IEEE Std 1500,致力于建立标准化的IP核供应商和用户之间的测试接口,简化核测试信息的复用;文章详细介绍了IEEE Std 1500标准的测试架构,使用方法和核测试描述语言CTL,同时给出标准中提出的SOC可测性设计方法.