Expression of the SOCS family in human chronic wound tissues: Potential implications for SOCS in chronic wound healing

Science.gov (United States)

Feng, Yi; Sanders, Andrew J.; Ruge, Fiona; Morris, Ceri-Ann; Harding, Keith G.; Jiang, Wen G.

2016-01-01

Cytokines play important roles in the wound healing process through various signalling pathways. The JAK-STAT pathway is utilised by most cytokines for signal transduction and is regulated by a variety of molecules, including suppressor of cytokine signalling (SOCS) proteins. SOCS are associated with inflammatory diseases and have an impact on cytokines, growth factors and key cell types involved in the wound-healing process. SOCS, a negative regulator of cytokine signalling, may hold the potential to regulate cytokine-induced signalling in the chronic wound-healing process. Wound edge tissues were collected from chronic venous leg ulcer patients and classified as non-healing and healing wounds. The expression pattern of seven SOCSs members, at the transcript and protein level, were examined in these tissues using qPCR and immunohistochemistry. Significantly higher levels of SOCS3 (P=0.0284) and SOCS4 (P=0.0376) in non-healing chronic wounds compared to the healing/healed chronic wounds were observed at the transcript level. Relocalisation of SOCS3 protein in the non-healing wound environment was evident in the investigated chronic biopsies. Thus, the results show that the expression of SOCS transcript indicated that SOCS members may act as a prognostic biomarker of chronic wounds. PMID:27635428

SOCS2 and SOCS3 expression in ulcerative colitis and their correlation with inflammatory response and immune response

Directory of Open Access Journals (Sweden)

Le Huang1

2017-05-01

Full Text Available Objective: To study the correlation of SOCS2 and SOCS3 expression in ulcerative colitis tissue with inflammatory response and immune response. Methods: Ulcerative colitis lesions and normal mucosa from colonoscopic biopsy in Central Hospital of Zibo Mining Refco Group Ltd between May 2014 and July 2016 were selected and enrolled in UC group and control group respectively. RNA was extracted to determine mRNA expression of SOCS2 and SOCS3 as well as inflammatory response JAKs/STATs pathway molecules; protein was extracted to determine the contents of immune response cytokines. Results: SOCS2 mRNA expression in intestinal mucosa of UC group was not significantly different from that of control group, and SOCS3 mRNA expression was significantly lower than that of control group; JAK1, JAK2, JAK3, STAT1, STAT3 and STAT5 mRNA expression as well as IFN-γ and IL-17 protein contents in intestinal mucosa of UC group were significantly higher than those of control group while IL-4 and IL-10 protein contents were significantly lower than those of control group; JAK1, JAK2, JAK3, STAT1, STAT3 and STAT5 mRNA expression as well as IFN-γ and IL-17 protein contents in UC group of intestinal mucosa with low SOCS3 expression were significantly higher than those of intestinal mucosa with high SOCS3 expression while IL-4 and IL-10 protein contents were significantly lower than those of intestinal mucosa with high SOCS3 expression. Conclusion: Low expression of SOCS3 in ulcerative colitis can aggravate the inflammatory reaction and cause the imbalance of Th1/Th2 and Th17/Treg immune response.

EXPRESSION OF SOCS3 AND SOCS5 MRNAS IN PERIPHERAL BLOOD MONONUCLEARS FROM THE PATIENTS WITH BRONCHIAL ASTHMA

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V. V. Lim

2014-01-01

Full Text Available We observed sixty patients with allergic bronchial asthma (ABA and 54 with non-allergic bronchial asthma (NABA. Quantitative SOCS3 and SOCS5 mRNA expression was evaluated by means of real-time PCR. Eighteen healthy persons served as a control group. In patients with bronchial asthma (irrespectively of pathogenetic form, a significant increase of SOCS3 transcription factor expression was detected in peripheral blood mononuclears, as compared with control group. This increase was more pronounced in NABA group. The mRNA SOCS5 level was significantly decreased in bronchial asthma patients, as compared to control group, especially, in ABA subgroup rather than in NABA patients. Thus, an increased expression of SOCS3 mRNA in BA patients could be regarded as a protective antiinflammatory response Decrease of SOCS5 mRNA expression in patients with bronchial asthma (being more pronounced in ABA, may be indicative for a deficiency in negative feedback regulation of gene transcription in allergic bronchial asthma.

Determinación astronómica de la Desviación de la Vertical

Science.gov (United States)

Pacheco, A. M.; Podestá, R. C.

A partir de las coordenadas astronómicas de Latitud y Longitud determinadas en la falla geológica de Nikizanga ubicada en las serranías de Pie de Palo, y, en base a un Punto Datum de referencia, se desarrolla la metodología para la determinación de la Desviación de la Vertical, que comprende la reducción de las observaciones astronómicas, transformaciones de coordenadas, aplicación de correcciones y el cálculo definitivo de los valores angulares de la Vertical. Estos estudios se iniciaron a sugerencia del Servicio Internacional de Latitud, International Polar Motion Service (IPMS), con el objeto de obtener en determinados puntos de la Tierra la Desviación de la Vertical y su variación, dentro de la nueva disciplina denominada Astrogeodinámica, con la idea de correlacionar estas variaciones con la predicción de grandes sismos.

Theoretical Studies of Electron Injection and E-Layer Build-Up in Astron; Etudes Theoriques sur l'Injection d'Electrons et la Formation de la Couche E dans l'Astron; Teoreticheskie izucheniya ehlektronnoj inzhektsii i narashchivaniya sloya-E v ustanovke ''Astron''; Estudios Teoricos de Electrones y Formacion de la Capa E en la Instalacion Astron

Energy Technology Data Exchange (ETDEWEB)

Killeen, J.; Neil, V. K.; Heckrotte, W. [Lawrence Radiation Laboratory, Livermore, CA (United States)

1966-04-15

High intensity beams of relativistic electrons injected into the Astron device can be trapped in part by the action of coherent electromagnetic self-forces. Through the appropriate design of external passive circuitry, axial electrostatic blow-up of the azimuthally injected beam can be prevented or inhibited. The self-forces result in a spread of particles in z-P{sub z} phase space, and part of the beam is trapped at the expense of the loss of the rest. In addition to this effect, for sufficiently high beam currents, the coupling of the relativistic beam to the passive circuitry can lead to significant loss of axial momentum through energy dissipation. A one-dimensional model of the actual Astron geometry has been investigated theoretically. Green's functions for the self-electric and self-magnetic fields have been calculated analytically and incorporated into the Vlasov equation governing the axial motion of the electrons. Results of the calculation allow some qualitative comparison with experimental results from the Astron experiment. As envisioned, the trapped electrons will form a cylindrical layer of sufficient intensity so that the self-magnetic field is comparable to the applied field. The mathematical model for the build-up of the electron layer and the self-field is the time-dependent Vlasov equation coupled with Maxwell's equations. The system is axially symmetric and complete neutralization is assumed. The field components Br and B{sub z} can be derived from a stream function {psi}( r, z, t). The canonical angular momentum is a constant of the motion, hence we can consider an electron distribution function f{sub e}( r, z, P{sub r}, P{sub z}). The partial differential equations for f{sub e} and {psi} are solved numerically by using finite difference methods. The phase space consists of over 160 000 points, that is 81 in z, 12 in r, 19 in P{sub z} and 9 in P{sub r}. At each step an integration of f{sub e} over momentum space yields the current density j

A Generalized SOC-OCV Model for Lithium-Ion Batteries and the SOC Estimation for LNMCO Battery

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Caiping Zhang

2016-11-01

Full Text Available A state-of-charge (SOC versus open-circuit-voltage (OCV model developed for batteries should preferably be simple, especially for real-time SOC estimation. It should also be capable of representing different types of lithium-ion batteries (LIBs, regardless of temperature change and battery degradation. It must therefore be generic, robust and adaptive, in addition to being accurate. These challenges have now been addressed by proposing a generalized SOC-OCV model for representing a few most widely used LIBs. The model is developed from analyzing electrochemical processes of the LIBs, before arriving at the sum of a logarithmic, a linear and an exponential function with six parameters. Values for these parameters are determined by a nonlinear estimation algorithm, which progressively shows that only four parameters need to be updated in real time. The remaining two parameters can be kept constant, regardless of temperature change and aging. Fitting errors demonstrated with different types of LIBs have been found to be within 0.5%. The proposed model is thus accurate, and can be flexibly applied to different LIBs, as verified by hardware-in-the-loop simulation designed for real-time SOC estimation.

SOCS-1 deficiency does not prevent diet-induced insulin resistance

DEFF Research Database (Denmark)

Emanuelli, Brice; Macotela, Yazmin; Boucher, Jérémie

2008-01-01

Obesity is associated with inflammation and increased expression of suppressor of cytokine signaling (SOCS) proteins, which inhibit cytokine and insulin signaling. Thus, reducing SOCS expression could prevent the development of obesity-induced insulin resistance. Using SOCS-1 knockout mice, we...... investigated the contribution of SOCS-1 in the development of insulin resistance induced by a high-fat diet (HFD). SOCS-1 knockout mice on HFD gained 70% more weight, displayed a 2.3-fold increase in epididymal fat pads mass and increased hepatic lipid content. This was accompanied by increased mRNA expression...... of leptin and the macrophage marker CD68 in white adipose tissue and of SREBP1c and FAS in liver. HFD also induced hyperglycemia in SOCS-1 deficient mice with impairment of glucose and insulin tolerance tests. Thus, despite the role of SOCS proteins in obesity-related insulin resistance, SOCS-1 deficiency...

The high brightness temperature of B0529+483 revealed by RadioAstron and implications for interstellar scattering

Science.gov (United States)

Pilipenko, S. V.; Kovalev, Y. Y.; Andrianov, A. S.; Bach, U.; Buttaccio, S.; Cassaro, P.; Cimò, G.; Edwards, P. G.; Gawroński, M. P.; Gurvits, L. I.; Hovatta, T.; Jauncey, D. L.; Johnson, M. D.; Kovalev, Yu A.; Kutkin, A. M.; Lisakov, M. M.; Melnikov, A. E.; Orlati, A.; Rudnitskiy, A. G.; Sokolovsky, K. V.; Stanghellini, C.; de Vicente, P.; Voitsik, P. A.; Wolak, P.; Zhekanis, G. V.

2018-03-01

The high brightness temperatures, Tb ≳ 1013 K, detected in several active galactic nuclei by RadioAstron space VLBI observations challenge theoretical limits. Refractive scattering by the interstellar medium may affect such measurements. We quantify the scattering properties and the sub-mas scale source parameters for the quasar B0529+483. Using RadioAstron correlated flux density measurements at 1.7, 4.8, and 22 GHz on projected baselines up to 240 000 km we find two characteristic angular scales in the quasar core, about 100 and 10 μas. Some indications of scattering substructure are found. Very high brightness temperatures, Tb ≥ 1013 K, are estimated at 4.8 and 22 GHz even taking into account the refractive scattering. Our findings suggest a clear dominance of the particle energy density over the magnetic field energy density in the core of this quasar.

Effective correlator for RadioAstron project

Science.gov (United States)

Sergeev, Sergey

This paper presents the implementation of programme FX-correlator for Very Long Baseline Interferometry, adapted for the project "RadioAstron". Software correlator implemented for heterogeneous computing systems using graphics accelerators. It is shown that for the task interferometry implementation of the graphics hardware has a high efficiency. The host processor of heterogeneous computing system, performs the function of forming the data flow for graphics accelerators, the number of which corresponds to the number of frequency channels. So, for the Radioastron project, such channels is seven. Each accelerator is perform correlation matrix for all bases for a single frequency channel. Initial data is converted to the floating-point format, is correction for the corresponding delay function and computes the entire correlation matrix simultaneously. Calculation of the correlation matrix is performed using the sliding Fourier transform. Thus, thanks to the compliance of a solved problem for architecture graphics accelerators, managed to get a performance for one processor platform Kepler, which corresponds to the performance of this task, the computing cluster platforms Intel on four nodes. This task successfully scaled not only on a large number of graphics accelerators, but also on a large number of nodes with multiple accelerators.

TARGETED ANALYSIS OF JAK-STAT-SOCS GENES IN DAIRY CATTLE

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Arun Sondur Jayappa

2015-12-01

Full Text Available The Janus kinase and signal transducer and activator of transcription (JAK-STAT pathway genes along with suppressors of cytokine signalling (SOCS family genes play a crucial role in controlling cytokine signals in the mammary gland and thus mammary gland development. Mammary gene expression studies showed differential expression patterns for all the JAK-STAT pathway genes. Gene expression studies using qRT-PCR revealed differential expression of SOCS2, SOCS4 and SOCS5 genes across the lactation cycle in dairy cows. Using genotypes from 1,546 Australian Holstein- Friesian bulls, a statistical model based on SNPs within 500kb of JAK-STAT pathway genes, and SOCS genes alone was carried out. The analysis suggested that these genes and pathways make a significant contribution to the Australian milk production traits. Selection of 24 SNPs close to SOCS1, SOCS3, SOCS5, SOCS7 and CISH genes were significantly associated with, Australian Profit Ranking (APR, Australian Selection Index (ASI and protein yield (PY. This study supports the view that there may be some merit in choosing SNPs around functionally relevant genes for the selection and genetic improvement schemes for dairy production traits.

Settling-velocity specific SOC distribution on hillslopes

DEFF Research Database (Denmark)

Hu, Yaxian; Berhe, Asmeret Asefaw; Fogel, Marilyn L.

The net effect of soil erosion by water, as a sink or source of atmospheric CO2, is determined by the spatial (re-)distribution and stability of eroded soil organic carbon (SOC). The depositional position of eroded SOC is a function of the transport distances of soil fractions where the SOC...... fractions. Eroding sandy soils and sediment were sampled after a series of rainfall events along a slope on a freshly seeded cropland in Jutland, Denmark. All the soil samples were fractionated into five settling classes using a settling tube apparatus. The spatial distribution of soil settling classes...... shows a coarsening effect immediately below the eroding slope, followed by a fining trend at the slope tail. The 13C values of soil fractions were more positive at the footslope than on the slope shoulder or at the slope tail, suggesting enhanced decomposition rate of fresh SOC input at the footslope...

Correlation between the model accuracy and model-based SOC estimation

International Nuclear Information System (INIS)

Wang, Qianqian; Wang, Jiao; Zhao, Pengju; Kang, Jianqiang; Yan, Few; Du, Changqing

2017-01-01

State-of-charge (SOC) estimation is a core technology for battery management systems. Considerable progress has been achieved in the study of SOC estimation algorithms, especially the algorithm on the basis of Kalman filter to meet the increasing demand of model-based battery management systems. The Kalman filter weakens the influence of white noise and initial error during SOC estimation but cannot eliminate the existing error of the battery model itself. As such, the accuracy of SOC estimation is directly related to the accuracy of the battery model. Thus far, the quantitative relationship between model accuracy and model-based SOC estimation remains unknown. This study summarizes three equivalent circuit lithium-ion battery models, namely, Thevenin, PNGV, and DP models. The model parameters are identified through hybrid pulse power characterization test. The three models are evaluated, and SOC estimation conducted by EKF-Ah method under three operating conditions are quantitatively studied. The regression and correlation of the standard deviation and normalized RMSE are studied and compared between the model error and the SOC estimation error. These parameters exhibit a strong linear relationship. Results indicate that the model accuracy affects the SOC estimation accuracy mainly in two ways: dispersion of the frequency distribution of the error and the overall level of the error. On the basis of the relationship between model error and SOC estimation error, our study provides a strategy for selecting a suitable cell model to meet the requirements of SOC precision using Kalman filter.

SOCS-1 localizes to the microtubule organizing complex-associated 20S proteasome.

Science.gov (United States)

Vuong, Bao Q; Arenzana, Teresita L; Showalter, Brian M; Losman, Julie; Chen, X Peter; Mostecki, Justin; Banks, Alexander S; Limnander, Andre; Fernandez, Neil; Rothman, Paul B

2004-10-01

The regulation of cytokine signaling is critical for controlling cellular proliferation and activation during an immune response. SOCS-1 is a potent inhibitor of Jak kinase activity and of signaling initiated by several cytokines. SOCS-1 protein levels are tightly regulated, and recent data suggest that SOCS-1 may regulate the protein levels of some signaling proteins by the ubiquitin proteasome pathway; however, the cellular mechanism by which SOCS-1 directs proteins for degradation is unknown. In this report, SOCS-1 is found to colocalize and biochemically copurify with the microtubule organizing complex (MTOC) and its associated 20S proteasome. The SOCS-1 SH2 domain is required for the localization of SOCS-1 to the MTOC. Overexpression of SOCS-1 targets Jak1 in an SH2-dependent manner to a perinuclear distribution resembling the MTOC-associated 20S proteasome. Analysis of MTOCs fractionated from SOCS-1-deficient cells demonstrates that SOCS-1 may function redundantly to regulate the localization of Jak1 to the MTOC. Nocodazole inhibits the protein turnover of SOCS-1, demonstrating that the minus-end transport of SOCS-1 to the MTOC-associated 20S proteasome is required to regulate SOCS-1 protein levels. These data link SOCS-1 directly with the proteasome pathway and suggest another function for the SH2 domain of SOCS-1 in the regulation of Jak/STAT signaling.

Interleaved Subtask Scheduling on Multi Processor SOC

NARCIS (Netherlands)

Zhe, M.

2006-01-01

The ever-progressing semiconductor processing technique has integrated more and more embedded processors on a single system-on-achip (SoC). With such powerful SoC platforms, and also due to the stringent time-to-market deadlines, many functionalities which used to be implemented in ASICs are

Defective interleukin-4/Stat6 activity correlates with increased constitutive expression of negative regulators SOCS-3, SOCS-7, and CISH in colon cancer cells.

Science.gov (United States)

Liu, Xiao Hong; Xu, Shuang Bing; Yuan, Jia; Li, Ben Hui; Zhang, Yan; Yuan, Qin; Li, Pin Dong; Li, Feng; Zhang, Wen Jie

2009-12-01

Interleukin-4 (IL-4)-induced Stat6 activities (phenotypes) vary among human cancer cells, of which the HT-29 cell line carries an active Stat6(high) phenotype, while Caco-2 carries a defective Stat6(null) phenotype, respectively. Cancer cells with Stat6(high) show resistance to apoptosis and exaggerated metastasis, suggesting the clinical significance of Stat6 phenotypes. We previously showed that Stat6(high) HT-29 cells exhibited low constitutive expression of Stat6-negative regulators SOCS-1 and SHP-1 because of gene hypermethylation. This study further examined the constitutive expression of other closely related SOCS family numbers including SOCS-3, SOCS-5, SOCS-7, and CISH using RT-PCR. Similar to SOCS-1 and SHP-1, Stat6(high) HT-29 cells expressed low constitutive mRNA of SOCS-3, SOCS-7, and CISH than Stat6(null) Caco-2 cells. Interestingly, DNA demethylation using 5-aza-2'-deoxycytidine in HT-29 cells up-regulated mRNA expression of the above genes, indicating a hypermethylation status, which was confirmed by methylation-specific sequencing in selected SOCS-3 gene. Furthermore, defective Stat6(null) Caco-2 exhibited impaired phosphorylation of Stat6 after IL-4 stimulation by flow cytometry, in keeping with the notion of an over-performed negative regulation. The findings that IL-4/Stat6 phenotypes show differential expression of multiple negative regulators suggest a model that a collective force of powerful negative regulators, directly and indirectly, acts on Stat6 activation, which may result in differential Stat6 phenotypes.

SPAD array based TOF SoC design for unmanned vehicle

Science.gov (United States)

Pan, An; Xu, Yuan; Xie, Gang; Huang, Zhiyu; Zheng, Yanghao; Shi, Weiwei

2018-03-01

As for the requirement of unmanned-vehicle mobile Lidar system, this paper presents a SoC design based on pulsed TOF depth image sensor. This SoC has a detection range of 300m and detecting resolution of 1.5cm. Pixels are made of SPAD. Meanwhile, SoC adopts a structure of multi-pixel sharing TDC, which significantly reduces chip area and improve the fill factor of light-sensing surface area. SoC integrates a TCSPC module to achieve the functionality of receiving each photon, measuring photon flight time and processing depth information in one chip. The SOC is designed in the SMIC 0.13μm CIS CMOS technology

Research on SOC Calibration of Large Capacity Lead Acid Battery

Science.gov (United States)

Ye, W. Q.; Guo, Y. X.

2018-05-01

Large capacity lead-acid battery is used in track electric locomotive, and State of Charge (SOC) is an important quantitative parameter of locomotive power output and operating mileage of power emergency recovery vehicle. But State of Charge estimation has been a difficult part in the battery management system. In order to reduce the SOC estimation error better, this paper uses the linear relationship of Open Circuit Voltage (OCV) and State of Charge to fit the SOC-OCV curve equation by MATLAB. The method proposed in this paper is small, easy to implement and can be used in the battery non-working state SOC estimation correction, improve the estimation accuracy of SOC.

Favorable prognostic value of SOCS2 and IGF-I in breast cancer

International Nuclear Information System (INIS)

Haffner, Michael C; Petridou, Barbara; Peyrat, Jean Phillipe; Révillion, Françoise; Müller-Holzner, Elisabeth; Daxenbichler, Günter; Marth, Christian; Doppler, Wolfgang

2007-01-01

Suppressor of cytokine signaling (SOCS) proteins comprise a protein family, which has initially been described as STAT induced inhibitors of the Jak/Stat pathway. Recent in vivo and in vitro studies suggest that SOCS proteins are also implicated in cancer. The STAT5 induced IGF-I acts as an endocrine and para/autocrine growth and differentiation factor in mammary gland development. Whereas high levels of circulating IGF-I have been associated with increased cancer risk, the role of autocrine acting IGF-I is less clear. The present study is aimed to elucidate the clinicopathological features associated with SOCS1, SOCS2, SOCS3, CIS and IGF-I expression in breast cancer. We determined the mRNA expression levels of SOCS1, SOCS2, SOCS3, CIS and IGF-I in 89 primary breast cancers by reverse transcriptase PCR. SOCS2 protein expression was further evaluated by immuno-blot and immunohistochemistry. SOCS2 expression inversely correlated with histopathological grade and ER positive tumors exhibited higher SOCS2 levels. Patients with high SOCS2 expression lived significantly longer (108.7 vs. 77.7 months; P = 0.015) and high SOCS2 expression proved to be an independent predictor for good prognosis (HR = 0.45, 95% CI 0.23 – 0.91, P = 0.026). In analogy to SOCS2, high IGF-I expression was an independent predictor for good prognosis in the entire patient cohort. In the subgroup of patients with lymph-node negative disease, high IGF-I was a strong predictor for favorable outcome in terms of overall survival and relapse free survival (HR = 0.075, 95% CI 0.014 – 0.388, P = 0.002). This is the first report on the favorable prognostic value of high SOCS2 expression in primary mammary carcinomas. Furthermore a strong association of high IGF-I expression levels with good prognosis was observed especially in lymph-node negative patients. Our results suggest that high expression of the STAT5 target genes SOCS2 and IGF-I is a feature of differentiated and less malignant tumors

Identification of suppressor of cytokine signalling (SOCS) 6, 7, 9 and CISH in rainbow trout Oncorhynchus mykiss and analysis of their expression in relation to other known trout SOCS.

Science.gov (United States)

Wang, Tiehui; Gao, Qian; Nie, Pin; Secombes, Christopher J

2010-10-01

Four new members of the SOCS family of molecules in rainbow trout (Oncorhynchus mykiss), CISH and SOCS6, 7 and 9, are described for the first time in this species. The genes had a wide tissue distribution in trout, and were detected in gills, skin, muscle, liver, spleen, head kidney, intestine and brain, with brain having the highest expression levels. Stimulation of a rainbow trout leucocyte cell line, RTS-11, (mononuclear/macrophage-like cells) with LPS or Poly I:C had no effect on the expression of these genes, although in both cases the previously identified SOCS1-3 genes were up-regulated. Similarly, stimulation of RTS-11 or RTG-2 (fibroblasts) cells with the trout recombinant cytokines IFN-gamma or IL-1beta had no effect on CISH or SOCS6, 7 and 9 expression. However, PMA stimulation did impact on SOCS6 and SOCS9 expression, and LPS stimulation of primary cultures or bacterial infection (Yersinia ruckeri) increased significantly CISH expression (as well as SOCS1 and SOCS2 or SOCS3 respectively). It is apparent that the type II SOCS genes (CISH, SOCS1-3) are particularly relevant to immune regulation in fish, although the intriguing expansion of the SOCS4/5 subgroup in fish requires further investigation as to their role and functional divergence. Copyright 2010 Elsevier Ltd. All rights reserved.

Favorable prognostic value of SOCS2 and IGF-I in breast cancer

Directory of Open Access Journals (Sweden)

Daxenbichler Günter

2007-07-01

Full Text Available Abstract Background Suppressor of cytokine signaling (SOCS proteins comprise a protein family, which has initially been described as STAT induced inhibitors of the Jak/Stat pathway. Recent in vivo and in vitro studies suggest that SOCS proteins are also implicated in cancer. The STAT5 induced IGF-I acts as an endocrine and para/autocrine growth and differentiation factor in mammary gland development. Whereas high levels of circulating IGF-I have been associated with increased cancer risk, the role of autocrine acting IGF-I is less clear. The present study is aimed to elucidate the clinicopathological features associated with SOCS1, SOCS2, SOCS3, CIS and IGF-I expression in breast cancer. Methods We determined the mRNA expression levels of SOCS1, SOCS2, SOCS3, CIS and IGF-I in 89 primary breast cancers by reverse transcriptase PCR. SOCS2 protein expression was further evaluated by immuno-blot and immunohistochemistry. Results SOCS2 expression inversely correlated with histopathological grade and ER positive tumors exhibited higher SOCS2 levels. Patients with high SOCS2 expression lived significantly longer (108.7 vs. 77.7 months; P = 0.015 and high SOCS2 expression proved to be an independent predictor for good prognosis (HR = 0.45, 95% CI 0.23 – 0.91, P = 0.026. In analogy to SOCS2, high IGF-I expression was an independent predictor for good prognosis in the entire patient cohort. In the subgroup of patients with lymph-node negative disease, high IGF-I was a strong predictor for favorable outcome in terms of overall survival and relapse free survival (HR = 0.075, 95% CI 0.014 – 0.388, P = 0.002. Conclusion This is the first report on the favorable prognostic value of high SOCS2 expression in primary mammary carcinomas. Furthermore a strong association of high IGF-I expression levels with good prognosis was observed especially in lymph-node negative patients. Our results suggest that high expression of the STAT5 target genes SOCS2 and IGF

Observatorio Astronómico De Cantabria

Science.gov (United States)

Domínguez, R. M.; Carrera, F. J.

The Astronomical Observatory of Cantabria is a center of the Consejería de Medio Ambiente del Gobierno de Cantabria managed by the Centro de Investigación del Medio Ambiente (CIMA), an autonomous organism which depends on such Consejería. The development of different activities of the Observatory is a joint collaboration between the University of Cantabria and the Agrupación Astronómica Cántabra (AstroCantabria). As part of the University of Cantabria, the Instituto de Física de Cantabria (IFCA, CSIC-UC) is in charge of the direction, management and coordination of scientific, observational, educational and outreach activities of the Observatory. AstroCantabria takes care of the outreach activities for the general public as well as the astronomical observations. In addition, it is responsible for the calibration and maintenance of the astronomical instrumentation of the Observatory. The Astronomical Observatory of Cantabria is located on the Southern edge of the Comunidad Autónoma de Cantabria, on the high plateau of La Lora (Valderredible county), at an altitude of 1,080m, with longitude 3∘ 56 ' 36' W and latitude 42∘ 46 ' 18' N. Rocamundo is the closest town. The Observatory aims to become a center of reference for scientific, observational, educational and public outreach activities in Cantabria. In the near future, an observational proposal system for outside users will be set in place.

Process modeling of a reversible solid oxide cell (r-SOC) energy storage system utilizing commercially available SOC reactor

International Nuclear Information System (INIS)

Mottaghizadeh, Pegah; Santhanam, Srikanth; Heddrich, Marc P.; Friedrich, K. Andreas; Rinaldi, Fabio

2017-01-01

Highlights: • An electric energy storage system was developed based on a commercially available SOC reactor. • Heat generated in SOFC mode of r-SOC is utilized in SOEC operation of r-SOC using latent heat storage. • A round trip efficiency of 54.3% was reached for the reference system at atmospheric pressure. • An improved process system design achieved a round-trip efficiency of 60.4% at 25 bar. - Abstract: The increase of intermittent renewable energy contribution in power grids has urged us to seek means for temporal decoupling of electricity production and consumption. A reversible solid oxide cell (r-SOC) enables storage of surplus electricity through electrochemical reactions when it is in electrolysis mode. The reserved energy in form of chemical compounds is then converted to electricity when the cell operates as a fuel cell. A process system model was implemented using Aspen Plus® V8.8 based on a commercially available r-SOC reactor experimentally characterized at DLR. In this study a complete self-sustaining system configuration is designed by optimal thermal integration and balance of plant. Under reference conditions a round trip efficiency of 54.3% was achieved. Generated heat in fuel cell mode is exploited by latent heat storage tanks to enable endothermic operation of reactor in its electrolysis mode. In total, out of 100 units of thermal energy stored in heat storage tanks during fuel cell mode, 90% was utilized to offset heat demand of system in its electrolysis mode. Parametric analysis revealed the significance of heat storage tanks in thermal management even when reactor entered its exothermic mode of electrolysis. An improved process system design demonstrates a system round-trip efficiency of 60.4% at 25 bar.

IL-10 and socs3 Are Predictive Biomarkers of Dengue Hemorrhagic Fever

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Lilian Karem Flores-Mendoza

2017-01-01

Full Text Available Background. Cytokines play important roles in the physiopathology of dengue infection; therefore, the suppressors of cytokine signaling (socs that control the type and timing of cytokine functions could be involved in the origin of immune alterations in dengue. Objective. To explore the association of cytokine and socs levels with disease severity in dengue patients. Methods. Blood samples of 48 patients with confirmed dengue infection were analyzed. Amounts of interleukins IL-2, IL-4, IL-6, and IL-10, interferon- (IFN- γ, and tumor necrosis factor- (TNF- α were quantified by flow cytometry, and the relative expression of socs1 and socs3 mRNA was quantified by real-time RT-PCR. Results. Increased levels of IL-10 and socs3 and lower expression of socs1 were found in patients with dengue hemorrhagic fever (DHF with respect to those with dengue fever (DF (p199.8-fold, socs1 (134 pg/ml have the highest sensitivity and specificity to discriminate between DF and DHF. Conclusion. Simultaneous changes in IL-10 and socs1/socs3 could be used as prognostic biomarkers of dengue severity.

Modulation of SOCS protein expression influences the interferon responsiveness of human melanoma cells

International Nuclear Information System (INIS)

Lesinski, Gregory B; Zimmerer, Jason M; Kreiner, Melanie; Trefry, John; Bill, Matthew A; Young, Gregory S; Becknell, Brian; Carson, William E III

2010-01-01

Endogenously produced interferons can regulate the growth of melanoma cells and are administered exogenously as therapeutic agents to patients with advanced cancer. We investigated the role of negative regulators of interferon signaling known as suppressors of cytokine signaling (SOCS) in mediating interferon-resistance in human melanoma cells. Basal and interferon-alpha (IFN-α) or interferon-gamma (IFN-γ)-induced expression of SOCS1 and SOCS3 proteins was evaluated by immunoblot analysis in a panel of n = 10 metastatic human melanoma cell lines, in human embryonic melanocytes (HEM), and radial or vertical growth phase melanoma cells. Over-expression of SOCS1 and SOCS3 proteins in melanoma cells was achieved using the PINCO retroviral vector, while siRNA were used to inhibit SOCS1 and SOCS3 expression. Tyr 701 -phosphorylated STAT1 (P-STAT1) was measured by intracellular flow cytometry and IFN-stimulated gene expression was measured by Real Time PCR. SOCS1 and SOCS3 proteins were expressed at basal levels in melanocytes and in all melanoma cell lines examined. Expression of the SOCS1 and SOCS3 proteins was also enhanced following stimulation of a subset of cell lines with IFN-α or IFN-γ. Over-expression of SOCS proteins in melanoma cell lines led to significant inhibition of Tyr 701 -phosphorylated STAT1 (P-STAT1) and gene expression following stimulation with IFN-α (IFIT2, OAS-1, ISG-15) or IFN-γ (IRF1). Conversely, siRNA inhibition of SOCS1 and SOCS3 expression in melanoma cells enhanced their responsiveness to interferon stimulation. These data demonstrate that SOCS proteins are expressed in human melanoma cell lines and their modulation can influence the responsiveness of melanoma cells to IFN-α and IFN-γ

Applying transport-distance specific SOC distribution to calibrate soil erosion model WaTEM

Science.gov (United States)

Hu, Yaxian; Heckrath, Goswin J.; Kuhn, Nikolaus J.

2016-04-01

Slope-scale soil erosion, transport and deposition fundamentally decide the spatial redistribution of eroded sediments in terrestrial and aquatic systems, which further affect the burial and decomposition of eroded SOC. However, comparisons of SOC contents between upper eroding slope and lower depositional site cannot fully reflect the movement of eroded SOC in-transit along hillslopes. The actual transport distance of eroded SOC is decided by its settling velocity. So far, the settling velocity distribution of eroded SOC is mostly calculated from mineral particle specific SOC distribution. Yet, soil is mostly eroded in form of aggregates, and the movement of aggregates differs significantly from individual mineral particles. This urges a SOC erodibility parameter based on actual transport distance distribution of eroded fractions to better calibrate soil erosion models. Previous field investigation on a freshly seeded cropland in Denmark has shown immediate deposition of fast settling soil fractions and the associated SOC at footslopes, followed by a fining trend at the slope tail. To further quantify the long-term effects of topography on erosional redistribution of eroded SOC, the actual transport-distance specific SOC distribution observed on the field was applied to a soil erosion model WaTEM (based on USLE). After integrating with local DEM, our calibrated model succeeded in locating the hotspots of enrichment/depletion of eroded SOC on different topographic positions, much better corresponding to the real-world field observation. By extrapolating into repeated erosion events, our projected results on the spatial distribution of eroded SOC are also adequately consistent with the SOC properties in the consecutive sample profiles along the slope.

The simple art of SoC design

CERN Document Server

Keating, Michael

2011-01-01

This book tackles head-on the challenges of digital design in the era of billion-transistor SoCs. It discusses fundamental design concepts in design and coding required to produce robust, functionally correct designs. It also provides specific techniques for measuring and minimizing complexity in RTL code. Finally, it discusses the tradeoff between RTL and high-level (C-based) design and how tools and languages must progress to address the needs of tomorrow's SoC designs.

Applicability of meteor radiant determination methods depending on orbit type. I. High-eccentric orbits

Science.gov (United States)

Svoren, J.; Neslusan, L.; Porubcan, V.

1993-07-01

It is evident that there is no uniform method of calculating meteor radiants which would yield reliable results for all types of cometary orbits. In the present paper an analysis of this problem is presented, together with recommended methods for various types of orbits. Some additional methods resulting from mathematical modelling are presented and discussed together with Porter's, Steel-Baggaley's and Hasegawa's methods. In order to be able to compare how suitable the application of the individual radiant determination methods is, it is necessary to determine the accuracy with which they approximate real meteor orbits. To verify the accuracy with which the orbit of a meteoroid with at least one node at 1 AU fits the original orbit of the parent body, we applied the Southworth-Hawkins D-criterion (Southworth, R.B., Hawkins, G.S.: 1963, Smithson. Contr. Astrophys 7, 261). D0.2 the fit is rather poor and the change of orbit unrealistic. The optimal methods with the smallest values of D for given types of orbits are shown in two series of six plots. The new method of rotation around the line of apsides we propose is very appropriate in the region of small inclinations. There is no doubt that Hasegawa's omega-adjustment method (Hasegawa, I.: 1990, Publ. Astron. Soc. Japan 42, 175) has the widest application. A comparison of the theoretical radiants with the observed radiants of seven known meteor showers is also presented.

Fish Suppressors of Cytokine Signaling (SOCS): Gene Discovery, Modulation of Expression and Function

Science.gov (United States)

Wang, Tiehui; Gorgoglione, Bartolomeo; Maehr, Tanja; Holland, Jason W.; Vecino, Jose L. González; Wadsworth, Simon; Secombes, Christopher J.

2011-01-01

The intracellular suppressors of cytokine signaling (SOCS) family members, including CISH and SOCS1 to 7 in mammals, are important regulators of cytokine signaling pathways. So far, the orthologues of all the eight mammalian SOCS members have been identified in fish, with several of them having multiple copies. Whilst fish CISH, SOCS3, and SOCS5 paralogues are possibly the result of the fish-specific whole genome duplication event, gene duplication or lineage-specific genome duplication may also contribute to some paralogues, as with the three trout SOCS2s and three zebrafish SOCS5s. Fish SOCS genes are broadly expressed and also show species-specific expression patterns. They can be upregulated by cytokines, such as IFN-γ, TNF-α, IL-1β, IL-6, and IL-21, by immune stimulants such as LPS, poly I:C, and PMA, as well as by viral, bacterial, and parasitic infections in member- and species-dependent manners. Initial functional studies demonstrate conserved mechanisms of fish SOCS action via JAK/STAT pathways. PMID:22203897

Practical Astronomical Activities during Daytime. (Spanish Title: Actividades Astronómicas Prácticas Diurnas.) Atividades Astronômicas Práticas Diurnas

Science.gov (United States)

Jackson, Eric

2009-12-01

These daytime astronomy activities arose from research done in New Zealand by a group of teachers and astronomers into the problems of teaching astronomy. This showed that it was generally regarded as a difficult subject to take, traditionally relying on books, films and models. The fortunate may have had a visit to an observatory or planetarium, the adventurous may have attempted an outdoor evening viewing session, which sometimes had weather-related difficulties. The problem of not having many 'hands-on' activities, the feelings of inadequate knowledge, the felt need for astronomical equipment and expertise become too daunting for many teachers to do the subject justice. If astronomy was to be taught then a way around these difficulties needed to be found. Our group, working with teachers and children using the constructivism teaching approach, found that the principles of astronomy could be discovered during the day when the students are at school. Working co-operatively they measured and recorded observations of their shadows caused by the motions and interactions of the nearest star, the Sun (Sol), and our planet, Earth. Because children were involved so personally they were much more interested in the results of the study. Astronomy became enthralling and challenging for both teacher and class after applying their daytime experiences to night time viewing at home and reporting back to class. Estas actividades astronómicas diurnas surgieron de una investigación hecha en NuevaZelandia por un grupo de maestros y astrónomos sobre los problemas de la enseñanza de la Astronomía. Este trabajo mostró que la Astronomía es generalmente considerada una disciplina difícil de enseñar, y tradicionalmente basada en libros, filmes y modelos. Los más afortunados pueden haber efectuado alguna visita a un observatorio o planetario, y los más aventajados pueden tal vez haber intentado una sesión de observación nocturna, las cuales sufren a veces de dificultades

Effect of SOCS1 overexpression on RPE cell activation by proinflammatory cytokines.

Science.gov (United States)

Bazewicz, Magdalena; Draganova, Dafina; Makhoul, Maya; Chtarto, Abdel; Elmaleh, Valerie; Tenenbaum, Liliane; Caspers, Laure; Bruyns, Catherine; Willermain, François

2016-09-06

The purpose of this study was to investigate the in vitro effect of Suppressor Of Cytokine Signaling 1 (SOCS1) overexpression in retinal pigment epithelium (RPE) cells on their activation by pro-inflammatory cytokines IFNγ, TNFα and IL-17. Retinal pigment epithelium cells (ARPE-19) were stably transfected with the control plasmid pIRES2-AcGFP1 or the plasmid pSOCS1-IRES2-AcGFP1. They were stimulated by IFNγ (150ng/ml), TNFα (30ng/ml) or IL-17 (100ng/ml). The levels of SOCS1 mRNA were measured by real-time PCR. Signal Transducer and Activator of Transcription 1 (STAT1) phosphorylation and IκBα expression were analysed by western Blot (WB). IL-8 secretion was analysed by ELISA and expression of MHCII molecules and ICAM-1/CD54 by flow cytometry. Our data show that SOCS1 mRNA overexpression in RPE cells prevents IFNγ-induced SOCS1 mRNA increase and IFNγ-mediated STAT1 phosphorylation. Moreover, SOCS1 overexpression in RPE cells inhibits IFNγ-induced decrease of IL-8 secretion and prevents IFNγ-induced MHC II and ICAM1/CD54 upregulation. However, SOCS1 overexpression does not affect TNFα-induced IκBα degradation nor block TNFα-induced or IL-17-induced IL-8 secretion. On the contrary, IL-17-induced secretion is increased by SOCS1 overexpression. In conclusion, SOCS1 overexpression in RPE cells inhibits some IFNγ-mediated responses that lead to uveitis development. This notion raises the possibility that SOCS1 overexpression could be a novel target for treating non-infectious uveitis. However, some proinflammatory effects of TNFα and IL-17 stimulation on RPE are not blocked by SOCS1 overexpression. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Constitutive expression of the K-domain of a Vaccinium corymbosum SOC1-like (VcSOC1-K) MADS-box gene is sufficient to promote flowering in tobacco.

Science.gov (United States)

Song, Guo-qing; Walworth, Aaron; Zhao, Dongyan; Hildebrandt, Britton; Leasia, Michael

2013-11-01

The K-domain of a blueberry-derived SOC1 -like gene promotes flowering in tobacco without negatively impacting yield, demonstrating potential for manipulation of flowering time in horticultural crops. The SUPPRESSOR OF OVEREXPRESSION OF CONSTANS 1 (SOC1) and SOC1-likes, belonging to the MIKC(c) (type II) MADS-box gene subfamily, are major floral activators and integrators of plant flowering. Both MADS-domains and K (Keratin)-domains are highly conserved in MIKC(c)-type MADS proteins. While there are many reports on overexpression of intact MIKC(c)-type MADS-box genes, few studies have been conducted to investigate the effects of the K-domains. In this report, a 474-bp K-domain of Vaccinium SOC1-like (VcSOC1-K) was cloned from the cDNA library of the northern highbush blueberry (Vaccinium corymbosum L.). Functional analysis of the VcSOC1-K was conducted by ectopically expressing of 35S:VcSOC1-K in tobacco. Reverse transcription PCR confirmed expression of the VcSOC1-K in T0 plants. Phenotypically, T1 transgenic plants (10 T1 plants/event) flowered sooner after seeding, and were shorter with fewer leaves at the time of flowering, than nontransgenic plants; but seed pod production of transgenic plants was not significantly affected. These results demonstrate that overexpression of the K-domain of a MIKC(c)-type MADS-box gene alone is sufficient to promote early flowering and more importantly without affecting seed production.

SOCS-1 Localizes to the Microtubule Organizing Complex-Associated 20S Proteasome

OpenAIRE

Vuong, Bao Q.; Arenzana, Teresita L.; Showalter, Brian M.; Losman, Julie; Chen, X. Peter; Mostecki, Justin; Banks, Alexander S.; Limnander, Andre; Fernandes, Neil; Rothman, Paul B.

2005-01-01

The regulation of cytokine signaling is critical for controlling cellular proliferation and activation during an immune response. SOCS-1 is a potent inhibitor of Jak kinase activity and of signaling initiated by several cytokines. SOCS-1 protein levels are tightly regulated, and recent data suggest that SOCS-1 may regulate the protein levels of some signaling proteins by the ubiquitin proteasome pathway; however, the cellular mechanism by which SOCS-1 directs proteins for degradation is unkno...

Trichostatin A, a histone deacetylase inhibitor, suppresses JAK2/STAT3 signaling via inducing the promoter-associated histone acetylation of SOCS1 and SOCS3 in human colorectal cancer cells.

Science.gov (United States)

Xiong, Hua; Du, Wan; Zhang, Yan-Jie; Hong, Jie; Su, Wen-Yu; Tang, Jie-Ting; Wang, Ying-Chao; Lu, Rong; Fang, Jing-Yuan

2012-02-01

Aberrant janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling is involved in the oncogenesis of several cancers. Suppressors of cytokine signaling (SOCS) genes and SH2-containing protein tyrosine phosphatase 1 (SHP1) proteins, which are negative regulators of JAK/STAT signaling, have been reported to have tumor suppressor functions. However, in colorectal cancer (CRC) cells, the mechanisms that regulate SOCS and SHP1 genes, and the cause of abnormalities in the JAK/STAT signaling pathway, remain largely unknown. The present study shows that trichostatin A (TSA), a histone deacetylase (HDAC) inhibitor, leads to the hyperacetylation of histones associated with the SOCS1 and SOCS3 promoters, but not the SHP1 promoter in CRC cells. This indicates that histone modifications are involved in the regulation of SOCS1 and SOCS3. Moreover, upregulation of SOCS1 and SOCS3 expression was achieved using TSA, which also significantly downregulated JAK2/STAT3 signaling in CRC cells. We also demonstrate that TSA suppresses the growth of CRC cells, and induces G1 cell cycle arrest and apoptosis through the regulation of downstream targets of JAK2/STAT3 signaling, including Bcl-2, survivin and p16(ink4a) . Therefore, our data demonstrate that TSA may induce SOCS1 and SOCS3 expression by inducing histone modifications and consequently inhibits JAK2/STAT3 signaling in CRC cells. These results also establish a mechanistic link between the inhibition of JAK2/STAT3 signaling and the anticancer action of TSA in CRC cells. Copyright © 2011 Wiley Periodicals, Inc.

STAT3-mediated constitutive expression of SOCS-3 in cutaneous T-cell lymphoma

DEFF Research Database (Denmark)

Brender, C; Nielsen, M; Kaltoft, K

2001-01-01

) obtained from affected skin from a patient with mycosis fungoides (MF) and from peripheral blood from a patient with Sezary syndrome (SS). In contrast, constitutive SOCS-3 expression is not found in the leukemic Jurkat T-cell line, the MOLT-4 acute lymphoblastic leukemia cell line, and the monocytic......, it has been hypothesized that an aberrant SOCS expression plays a role in neoplastic transformation. This study reports on a constitutive SOCS-3 expression in cutaneous T-cell lymphoma (CTCL) cell lines. SOCS-3 protein is constitutively expressed in tumor cell lines (but not in nonmalignant T cells...... leukemic cell line U937. Expression of SOCS-3 coincides with a constitutive activation of STAT3 in CTCL tumor cells, and stable transfection of CTCL tumor cells with a dominant negative STAT3 strongly inhibits SOCS-3 expression, whereas transfection with wild-type STAT3 does not. Moreover, the reduced SOCS...

Essential issues in SOC design designing complex systems-on-chip

CERN Document Server

Lin, Youn-long Steve

2007-01-01

Covers issues related to system-on-chip (SoC) design. This book covers IP development, verification, integration, chip implementation, testing and software. It contains valuable academic and industrial examples for those involved with the design of complex SOCs.

Adventures in order and chaos : a scientific autobiography

Science.gov (United States)

Contopoulos, George

The field of Order and Chaos had a remarkable expansion in the last 50 years. The main reason was the use of computers, and the development of new theoretical methods that we call now 'the theory of chaos'. The author describes this fascinating period in a relaxed and sometimes humorous autobiographical way. He relates his interactions with many people in dynamical astronomy and he quotes several anecdotes from these interactions. He refers also to his experiences when he served in various international positions, such as general secretary of the IAU and chairman of the journal Astronomy and Astrophysics. In recent years the theory of chaos has been extended to new areas, like relativity, cosmology and quantum mechanics and it continues expanding in almost all branches of physics. The book describes many important ideas in this field in a simple way. It refers also to problems of more general interest, like writing papers and giving lectures and the interaction of authors and referees. Finally it gives some useful prospects for the future of dynamical astronomy and related fields. George Contopoulos, PhD U.Athens1953; Professor of Astronomy U.Thessaloniki 1957-75; U.Athens 1975-96; Emeritus 1996-; Member, Academy of Athens 1997-. Visiting Professor Yale U., Harvard U., MIT, Cornell U., U.Chicago, U.Maryland, U. Florida, Florida State U., U. Milan; Res. Associate, Yerkes Obs., Inst.Adv.Study Princeton, Inst.Space Studies, Goddard Flight Center, Columbia U., ESO. Author or Editor of 15 books, and about 250 papers on Galactic Dynamics, Relativity and Celestial Mechanics. Positions held: Gen.Secretary of the IAU; Director General Nat.Obs.of Greece, Pres.Hellenic Astron.Soc.; Nat.Representative of Greece in NATO, etc. Distinctions: Amer. Astron.Soc. Brouwer Prize; U.Chicago, Honorary Doctor's Degree; IAU, Pres. Commission 33 (Galaxy); Member Academia Europaea; Associate Royal Astron. Soc.; Chairman of the European Journal "Astronomy and Astrophysics"; Assoc. Editor of

Mergers between elliptical galaxies and the thickening of the Fundamental Plane

NARCIS (Netherlands)

González-Garciá, A. C.; Albada, T. S. van

2003-01-01

Published in: Mon. Not. R. Astron. Soc. 342 (2003) L36 citations recorded in [Science Citation Index] Abstract: We have carried out computer simulations to study the effect of merging on the fundamental plane (FP) relation. Initially, systems are spherical Jaffe models following a simple scaling

Probing the innermost regions of AGN jets and their magnetic fields with RadioAstron. II. Observations of 3C 273 at minimum activity

Science.gov (United States)

Bruni, G.; Gómez, J. L.; Casadio, C.; Lobanov, A.; Kovalev, Y. Y.; Sokolovsky, K. V.; Lisakov, M. M.; Bach, U.; Marscher, A.; Jorstad, S.; Anderson, J. M.; Krichbaum, T. P.; Savolainen, T.; Vega-García, L.; Fuentes, A.; Zensus, J. A.; Alberdi, A.; Lee, S.-S.; Lu, R.-S.; Pérez-Torres, M.; Ros, E.

2017-08-01

Context. RadioAstron is a 10 m orbiting radio telescope mounted on the Spektr-R satellite, launched in 2011, performing Space Very Long Baseline Interferometry (SVLBI) observations supported by a global ground array of radio telescopes. With an apogee of 350 000 km, it is offering for the first time the possibility to perform μas-resolution imaging in the cm-band. Aims: The RadioAstron active galactic nuclei (AGN) polarization Key Science Project (KSP) aims at exploiting the unprecedented angular resolution provided by RadioAstron to study jet launching/collimation and magnetic-field configuration in AGN jets. The targets of our KSP are some of the most powerful blazars in the sky. Methods: We present observations at 22 GHz of 3C 273, performed in 2014, designed to reach a maximum baseline of approximately nine Earth diameters. Reaching an angular resolution of 0.3 mas, we study a particularly low-activity state of the source, and estimate the nuclear region brightness temperature, comparing with the extreme one detected one year before during the RadioAstron early science period. We also make use of the VLBA-BU-BLAZAR survey data, at 43 GHz, to study the kinematics of the jet in a 1.5-yr time window. Results: We find that the nuclear brightness temperature is two orders of magnitude lower than the exceptionally high value detected in 2013 with RadioAstron at the same frequency (1.4 × 1013 K, source-frame), and even one order of magnitude lower than the equipartition value. The kinematics analysis at 43 GHz shows that a new component was ejected 2 months after the 2013 epoch, visible also in our 22 GHz map presented here. Consequently this was located upstream of the core during the brightness temperature peak. Fermi-LAT observations for the period 2010-2014 do not show any γ-ray flare in conjunction with the passage of the new component by the core at 43 GHz. Conclusions: These observations confirm that the previously detected extreme brightness temperature in

Medicago truncatula SOC1 Genes Are Up-regulated by Environmental Cues That Promote Flowering

Directory of Open Access Journals (Sweden)

Jared B. Fudge

2018-04-01

Full Text Available Like Arabidopsis thaliana, the flowering of the legume Medicago truncatula is promoted by long day (LD photoperiod and vernalization. However, there are differences in the molecular mechanisms involved, with orthologs of two key Arabidopsis thaliana regulators, FLOWERING LOCUS C (FLC and CONSTANS (CO, being absent or not having a role in flowering time function in Medicago. In Arabidopsis, the MADS-box transcription factor gene, SUPPRESSOR OF OVEREXPRESSION OF CONSTANS 1 (AtSOC1, plays a key role in integrating the photoperiodic and vernalization pathways. In this study, we set out to investigate whether the Medicago SOC1 genes play a role in regulating flowering time. Three Medicago SOC1 genes were identified and characterized (MtSOC1a–MtSOC1c. All three MtSOC1 genes, when heterologously expressed, were able to promote earlier flowering of the late-flowering Arabidopsis soc1-2 mutant. The three MtSOC1 genes have different patterns of expression. However, consistent with a potential role in flowering time regulation, all three MtSOC1 genes are expressed in the shoot apex and are up-regulated in the shoot apex of plants in response to LD photoperiods and vernalization. The up-regulation of MtSOC1 genes was reduced in Medicago fta1-1 mutants, indicating that they are downstream of MtFTa1. Insertion mutant alleles of Medicago soc1b do not flower late, suggestive of functional redundancy among Medicago SOC1 genes in promoting flowering.

Centro astronómico de Calar-Alto Almería – España

Directory of Open Access Journals (Sweden)

Margarit, Salvador

1980-08-01

Full Text Available The Basic Agreement of Cooperation in Scientific Research and Technological development signed by the Spanish and West German governments in 1970, served as a framework for the agreement signed in 1972 by the National Astronomical Commission and the Max-Planck Society, for the setting up of the «Spanish-German Astronomical Centre». Construction work was started in 1973 on the Calar-Alto (2,168 m, the highest point in the Sierra de los Filabres in the province of Almería. At present the last of the domed buildings, which is intented to accommodate a 3.5 m diameter Telescope and should go into operation in 1983, is at the completion stage. By this date all work will have been completed, with four domed buildings for telescopes of different sizes and the buildings for laboratory, living quarters, services and workshops needed for the use of the scientific instruments. The 1.52 m diameter National Astronomical Observatory telescope has been installed in a separate building beside the infrastructure of the Spanish-German Astronomical Centre.

El Convenio Básico de Cooperación en la Investigación Científica y en el Desarrollo tecnológico suscrito entre los gobiernos de España y de la República Federal de Alemania en 1970, sirvió de marco para el acuerdo firmado en 1972 entre la Comisión Nacional de Astronomía y la Sociedad Max-Planck, para el establecimiento del «Centro Astronómico» Hispano-Alemán. En 1973 se iniciaron los trabajos de Obras en Calar-Alto (2.168 m cota máxima de la Sierra de los Filabres en la provincia de Almena. Actualmente se halla en fase de terminación el último de los edificios de Cúpula destinado a albergar un Telescopio de 3,5 m de diámetro y cuya puesta en servicio se prevé en 1983. Para entonces quedará culminada la realización completa con cuatro edificios de Cúpula para telescopios de diferentes tamaños y las edificaciones destinadas a laboratorio, residencia, viviendas, servicios y

Over-expression of KdSOC1 gene affected plantlet morphogenesis in Kalanchoe daigremontiana.

Science.gov (United States)

Zhu, Chen; Wang, Li; Chen, Jinhua; Liu, Chenglan; Zeng, Huiming; Wang, Huafang

2017-07-17

Kalanchoe daigremontiana reproduces asexually by producing plantlets along the leaf margin. The aim of this study was to identify the function of the SUPPRESSOR OF OVEREXPRESSION OF CONSTANS 1 gene in Kalanchoe daigremontiana (KdSOC1) during plantlet morphogenesis. In this study, KdSOC1 gene expression was detected at stem cell niche during in vitro somatic embryogenesis and plantlet morphogenesis. Disrupting endogenous auxin transportation suppressed the KdSOC1 gene response. Knockdown of the KdSOC1 gene caused a defect in cotyledon formation during the early heart stage of somatic embryogenesis. Over-expression (OE) of the KdSOC1 gene resulted in asymmetric plantlet distribution, a reduced number of plantlets, thicker leaves, and thicker vascular fibers. Higher KdPIN1 gene expression and auxin content were found in OE plant compared to those of wild-type plant leaves, which indicated possible KdSOC1 gene role in affecting auxin distribution and accumulation. KdSOC1 gene OE in DR5-GUS Arabidopsis reporting lines resulted in an abnormal auxin response pattern during different stages of somatic embryogenesis. In summary, the KdSOC1 gene OE might alter auxin distribution and accumulation along leaf margin to initiate plantlet formation and distribution, which is crucial for plasticity during plantlet formation under various environmental conditions.

Deletion of skeletal muscle SOCS3 prevents insulin resistance in obesity

DEFF Research Database (Denmark)

Beck Jørgensen, Sebastian; O'Neill, Hayley M; Sylow, Lykke

2013-01-01

Obesity is associated with chronic low-grade inflammation that contributes to defects in energy metabolism and insulin resistance. Suppressor of cytokine signaling (SOCS)-3 expression is increased in skeletal muscle of obese humans. SOCS3 inhibits leptin signaling in the hypothalamus and insulin...... of hyperinsulinemia and insulin resistance because of enhanced skeletal muscle insulin receptor substrate 1 (IRS1) and Akt phosphorylation that resulted in increased skeletal muscle glucose uptake. These data indicate that skeletal muscle SOCS3 does not play a critical role in regulating muscle development or energy...... expenditure, but it is an important contributing factor for inhibiting insulin sensitivity in obesity. Therapies aimed at inhibiting SOCS3 in skeletal muscle may be effective in reversing obesity-related glucose intolerance and insulin resistance....

SOCS3 inhibiting migration of A549 cells correlates with PYK2 signaling in vitro

Directory of Open Access Journals (Sweden)

Zhang Qingfu

2008-05-01

Full Text Available Abstract Background Suppressor of cytokine signaling 3 (SOCS3 is considered to inhibit cytokine responses and play a negative role in migration of various cells. Proline-rich tyrosine kinase 2 (PYK2 is a non-receptor kinase and has been found crucial to cell motility. However, little is known about whether SOCS3 could regulate PYK2 pro-migratory function in lung cancer. Methods The methylation status of SOCS3 was investigated in HBE and A549 cell lines by methylation-specific PCR. A549 cells were either treated with a demethylation agent 5-aza-2'-deoxycytidine or transfected with three SOCS3 mutants with various functional domains deleted. Besides, cells were pretreated with a proteasome inhibitor β-lactacystin where indicated. The effects of SOCS3 up-regulation on PYK2 expression, PYK2 and ERK1/2 phosphorylations were assessed by western blot using indicated antibodies. RT-PCR was used to estimate PYK2 mRNA levels. Transwell experiments were performed to evaluate cell migration. Results SOCS3 expression was found impaired in A549 cells and higher PYK2 activity was correlated with enhanced cell migration. We identified that SOCS3 was aberrantly methylated in the exon 2, and 5-aza-2'-deoxycytidine restored SOCS3 expression. Reactivation of SOCS3 attenuated PYK2 expression and phosphorylation, cell migration was inhibited as well. Transfection studies indicated that exogenous SOCS3 interacted with PYK2, and both the Src homology 2 (SH2 and the kinase inhibitory region (KIR domains of SOCS3 contributed to PYK2 binding. Furthermore, SOCS3 was found to inhibit PYK2-associated ERK1/2 activity in A549 cells. SOCS3 possibly promoted degradation of PYK2 in a SOCS-box-dependent manner and interfered with PYK2-related signaling events, such as cell migration. Conclusion These data indicate that SOCS3 negatively regulates cell motility and decreased SOCS3 induced by methylation may confer a migration advantage to A549 cells. These results also suggest a

Probing the Innermost Regions of AGN Jets and Their Magnetic Fields with RadioAstron. I. Imaging BL Lacertae at 21 Microarcsecond Resolution

Science.gov (United States)

Gómez, José L.; Lobanov, Andrei P.; Bruni, Gabriele; Kovalev, Yuri Y.; Marscher, Alan P.; Jorstad, Svetlana G.; Mizuno, Yosuke; Bach, Uwe; Sokolovsky, Kirill V.; Anderson, James M.; Galindo, Pablo; Kardashev, Nikolay S.; Lisakov, Mikhail M.

2016-02-01

We present the first polarimetric space very long baseline interferometry (VLBI) imaging observations at 22 GHz. BL Lacertae was observed in 2013 November 10 with the RadioAstron space VLBI mission, including a ground array of 15 radio telescopes. The instrumental polarization of the space radio telescope is found to be less than 9%, demonstrating the polarimetric imaging capabilities of RadioAstron at 22 GHz. Ground-space fringes were obtained up to a projected baseline distance of 7.9 Earth diameters in length, allowing us to image the jet in BL Lacertae with a maximum angular resolution of 21 μas, the highest achieved to date. We find evidence for emission upstream of the radio core, which may correspond to a recollimation shock at about 40 μas from the jet apex, in a pattern that includes other recollimation shocks at approximately 100 and 250 μas from the jet apex. Polarized emission is detected in two components within the innermost 0.5 mas from the core, as well as in some knots 3 mas downstream. Faraday rotation analysis, obtained from combining RadioAstron 22 GHz and ground-based 15 and 43 GHz images, shows a gradient in rotation measure and Faraday-corrected polarization vector as a function of position angle with respect to the core, suggesting that the jet in BL Lacertae is threaded by a helical magnetic field. The intrinsic de-boosted brightness temperature in the unresolved core exceeds 3× {10}12 K, suggesting, at the very least, departure from equipartition of energy between the magnetic field and radiating particles.

Evaluation of SOC for the presumptive identification of Candida albicans and Cryptococcus neoformans.

Science.gov (United States)

Fleming, W H; Knezek, K L; Dorn, G L

1987-01-01

SOC, a fungal growth medium composed of Solryth, oxgall, and caffeic acid, was evaluated as a medium to provide rapid, differential identification of Candida albicans and Cryptococcus neoformans. Using a variety of common isolation media to produce the yeast inocula, the germ tube methods tested ranked in the following order of decreasing sensitivity: SOC (97% +/- 1), serum (92% +/- 5), rabbit coagulase plasma with EDTA in combination with tryptic soy broth (89% +/- 5), TOC (89% +/- 6), and rabbit coagulase plasma with EDTA (83% +/- 4). In chlamydospore production, SOC also proved to be the most sensitive after 24 h incubation: SOC (96% +/- 2), TOC (80% +/- 2), and cornmeal-Tween 80 agar (14% +/- 3). Other medically important yeasts showed normal patterns of growth within 24 h on SOC, thus assisting in their identification. Eighty strains of Cryptococcus neoformans showed characteristic brown pigmentation on SOC and TOC within 18 h, while all other species of the genus Cryptococcus and 229 Candida isolates did not show a change in pigmentation.

Estimation of power lithium-ion battery SOC based on fuzzy optimal decision

Science.gov (United States)

He, Dongmei; Hou, Enguang; Qiao, Xin; Liu, Guangmin

2018-06-01

In order to improve vehicle performance and safety, need to accurately estimate the power lithium battery state of charge (SOC), analyzing the common SOC estimation methods, according to the characteristics open circuit voltage and Kalman filter algorithm, using T - S fuzzy model, established a lithium battery SOC estimation method based on the fuzzy optimal decision. Simulation results show that the battery model accuracy can be improved.

What are the effects of agricultural management on soil organic carbon (SOC) stocks?

DEFF Research Database (Denmark)

Söderström, Bo; Hedlund, Katarina; Jackson, Louise E.

2014-01-01

the physical and biological properties of the soil. Intensification of agriculture and land-use change from grasslands to croplands are generally known to deplete SOC stocks. The depletion is exacerbated through agricultural practices with low return of organic material and various mechanisms......Changes in soil organic carbon (SOC) stocks significantly influence the atmospheric C concentration. Agricultural management practices that increase SOC stocks thus may have profound effects on climate mitigation. Additional benefits include higher soil fertility since increased SOC stocks improve......, such as oxidation/mineralization, leaching and erosion. However, a systematic review comparing the efficacy of different agricultural management practices to increase SOC stocks has not yet been produced. Since there are diverging views on this matter, a systematic review would be timely for framing policies...

The impact of soil redistribution on SOC pools in a Mediterranean agroforestry catchment

Science.gov (United States)

Quijano, Laura; Gaspar, Leticia; Lizaga, Iván; Navas, Ana

2017-04-01

Soil redistribution processes play an important role influencing the spatial distribution patterns of soil and associated soil organic carbon (SOC) at landscape scale. Information on drivers of SOC dynamics is key for evaluating both soil degradation and SOC stability that can affect soil quality and sustainability. 137Cs measurements provide a very effective tool to infer spatial patterns of soil redistribution and quantify soil redistribution rates in different landscapes, but to date these data are scarce in mountain Mediterranean agroecosystems. We evaluate the effect of soil redistribution on SOC and SOC pools in relation to land use in a Mediterranean mountain catchment (246 ha). To this purpose, two hundred and four soil bulk cores were collected on a 100 m grid in the Estaña lakes catchment located in the central sector of the Spanish Pyrenees (31T 4656250N 295152E). The study area is an agroforestry and endorheic catchment characterized by the presence of evaporite dissolution induced dolines, some of which host permanent lakes. The selected landscape is representative of rainfed areas of Mediterranean continental climate with erodible lithology and shallow soils, and characterized by an intense anthropogenic activity through cultivation and water management. The cultivated and uncultivated areas are heterogeneously distributed. SOC and SOC pools (the active and decomposable fraction, ACF and the stable carbon fraction SCF) were measured by the dry combustion method and soil redistribution rates were derived from 137Cs measurements. The results showed that erosion predominated in the catchment, most of soil samples were identified as eroded sites (n=114) with an average erosion rate of 26.9±51.4 Mg ha-1 y-1 whereas the mean deposition rate was 13.0±24.2 Mg ha-1 y-1. In cultivated soils (n=54) the average of soil erosion rate was significantly higher (78.5±74.4 Mg ha-1 y-1) than in uncultivated soils (6.8±10.4 Mg ha-1 y-1). Similarly, the mean of soil

A Influência da Escola e da Mídia na Obtenção dos Conhecimentos Astronômicos

Science.gov (United States)

da Cunha, W. S.; Voelzke, M. R.; Amaral, L. H.

2006-08-01

O universo em que vivemos possui segredos jamais imaginados pelo homem, fruto da pequena proporção que ocupamos diante de um cosmos infinito. A astronomia funciona como um instrumento que sacia a sede humana em desvendar esses segredos, estudando as galáxias, quasares, pulsares além da existência de todos os elementos que preenchem o espaço cósmico, o vácuo, não mais vazio como se pensou em outros tempos. A mídia explora esse campo de forma mística e também científica. A difusão adequada e dentro dos padrões educacionais vigentes, de conceitos astronômicos, se faz necessária, devido sua presença nos conteúdos escolares, centros de ciência e na mídia, de modo geral. A reforma do Currículo Básico da Escola Pública da maioria dos Estados brasileiros introduziu conceitos astronômicos desde a pré-escola até o Ensino Médio. Num estudo realizado com 1.032 alunos do Ensino Médio de seis escolas estaduais, revelou-se através da aplicação de um questionário que abordava conheciment os básicos em astronomia, como estes foram adquiridos e qual era a infra-estrutura oferecida pela escola: para 66,2% dos entrevistados o professor já fez alguma apresentação a respeito de astronomia. O presente estudo revelou também que 44,5% dos alunos entrevistados adquiriram seus conhecimentos astronômicos na escola, 28,1% através da televisão e 27,4% afirmaram que seus conhecimentos foram obtidos através de outros tipos de mídia (internet, filmes e revistas). Embora o estudo revele claramente que há certo equilíbrio na forma em que os alunos obtiveram seus conhecimentos astronômicos, a mídia ainda explora e muitas vezes desperta o interesse pela astronomia com assuntos que não fazem parte de nosso cotidiano como, por exemplo, o homem na Lua, os projetos espaciais e a primeira viagem de um astronauta brasileiro no espaço. Porém, em certos casos, a mídia pode promover conhecimentos incompletos ou mesmo equivocados sobre os conceitos que envolvam

Selection of key terrain attributes for SOC model

DEFF Research Database (Denmark)

Greve, Mogens Humlekrog; Adhikari, Kabindra; Chellasamy, Menaka

As an important component of the global carbon pool, soil organic carbon (SOC) plays an important role in the global carbon cycle. SOC pool is the basic information to carry out global warming research, and needs to sustainable use of land resources. Digital terrain attributes are often use...... was selected, total 2,514,820 data mining models were constructed by 71 differences grid from 12m to 2304m and 22 attributes, 21 attributes derived by DTM and the original elevation. Relative importance and usage of each attributes in every model were calculated. Comprehensive impact rates of each attribute...

An Online SOC and SOH Estimation Model for Lithium-Ion Batteries

Directory of Open Access Journals (Sweden)

Shyh-Chin Huang

2017-04-01

Full Text Available The monitoring and prognosis of cell degradation in lithium-ion (Li-ion batteries are essential for assuring the reliability and safety of electric and hybrid vehicles. This paper aims to develop a reliable and accurate model for online, simultaneous state-of-charge (SOC and state-of-health (SOH estimations of Li-ion batteries. Through the analysis of battery cycle-life test data, the instantaneous discharging voltage (V and its unit time voltage drop, V′, are proposed as the model parameters for the SOC equation. The SOH equation is found to have a linear relationship with 1/V′ times the modification factor, which is a function of SOC. Four batteries are tested in the laboratory, and the data are regressed for the model coefficients. The results show that the model built upon the data from one single cell is able to estimate the SOC and SOH of the three other cells within a 5% error bound. The derived model is also proven to be robust. A random sampling test to simulate the online real-time SOC and SOH estimation proves that this model is accurate and can be potentially used in an electric vehicle battery management system (BMS.

NEW EPICS/RTEMS IOC BASED ON ALTERA SOC AT JEFFERSON LAB

Energy Technology Data Exchange (ETDEWEB)

Yan, Jianxun [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States); Seaton, Chad [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States); Allison, Trent L. [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States); Bevins, Brian S. [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States); Cuffe, Anthony W. [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States)

2018-02-01

A new EPICS/RTEMS IOC based on the Altera System-on-Chip (SoC) FPGA is being designed at Jefferson Lab. The Altera SoC FPGA integrates a dual ARM Cortex-A9 Hard Processor System (HPS) consisting of processor, peripherals and memory interfaces tied seamlessly with the FPGA fabric using a high-bandwidth interconnect backbone. The embedded Altera SoC IOC has features of remote network boot via U-Boot from SD card or QSPI Flash, 1Gig Ethernet, 1GB DDR3 SDRAM on HPS, UART serial ports, and ISA bus interface. RTEMS for the ARM processor BSP were built with CEXP shell, which will dynamically load the EPICS applications at runtime. U-Boot is the primary bootloader to remotely load the kernel image into local memory from a DHCP/TFTP server over Ethernet, and automatically run RTEMS and EPICS. The first design of the SoC IOC will be compatible with Jefferson Lab’s current PC104 IOCs, which have been running in CEBAF 10 years. The next design would be mounting in a chassis and connected to a daughter card via standard HSMC connectors. This standard SoC IOC will become the next generation of low-level IOC for the accelerator controls at Jefferson Lab.

Suppressor of cytokine signaling (SOCS)5 ameliorates influenza infection via inhibition of EGFR signaling.

Science.gov (United States)

Kedzierski, Lukasz; Tate, Michelle D; Hsu, Alan C; Kolesnik, Tatiana B; Linossi, Edmond M; Dagley, Laura; Dong, Zhaoguang; Freeman, Sarah; Infusini, Giuseppe; Starkey, Malcolm R; Bird, Nicola L; Chatfield, Simon M; Babon, Jeffrey J; Huntington, Nicholas; Belz, Gabrielle; Webb, Andrew; Wark, Peter Ab; Nicola, Nicos A; Xu, Jianqing; Kedzierska, Katherine; Hansbro, Philip M; Nicholson, Sandra E

2017-02-14

Influenza virus infections have a significant impact on global human health. Individuals with suppressed immunity, or suffering from chronic inflammatory conditions such as COPD, are particularly susceptible to influenza. Here we show that suppressor of cytokine signaling (SOCS) five has a pivotal role in restricting influenza A virus in the airway epithelium, through the regulation of epidermal growth factor receptor (EGFR). Socs5 -deficient mice exhibit heightened disease severity, with increased viral titres and weight loss. Socs5 levels were differentially regulated in response to distinct influenza viruses (H1N1, H3N2, H5N1 and H11N9) and were reduced in primary epithelial cells from COPD patients, again correlating with increased susceptibility to influenza. Importantly, restoration of SOCS5 levels restricted influenza virus infection, suggesting that manipulating SOCS5 expression and/or SOCS5 targets might be a novel therapeutic approach to influenza.

NIRS as an alternative to conventional soil analysis for Greenland soils (focus on SOC)

DEFF Research Database (Denmark)

Knadel, Maria; Ogric, Mateja; Adhikari, Kabindra

Soil organic carbon (SOC) is an important soil property. It is the main constituents of soil organic matter and a good indicator of soil quality. The estimation and mapping of SOC content could be used to select potential agricultural areas in the Arctic areas. However, conventional analysis of SOC...... are time consuming and expensive. They involve a lot of sample preparation, and chemicals and are destructive. Near infrared spectroscopy (NIRS) in the range between 400 and 2500 nm is an alternative method for SOC analysis. It is fast and non-destructive. The aims of this study where to test...... the feasibility of using NIRS to estimate SOC content on a landscape and field scale in Greenland. Partial Least squares regression models were built to correlated soil spectra and their reference SOC data to develop calibration models. Very good predictive ability for both landscape and field scale were obtained...

Synergy of SOCS-1 Inhibition and Microbial-Based Cancer Vaccines

Science.gov (United States)

2013-09-01

SH2 domain; a docking motif for interaction with tyrosine...IL‐ 4, IL‐7, IL‐15), IFN‐α, IFN‐γ, and IL‐12. While the SH2 domain targets the SOCS proteins to specific molecules within the JAK‐ STAT pathway, the...SOCS‐box functions as an E3 ubiquitin ligase, promoting degradation of the cytokine receptor complex. SOCS1 also contains a kinase inhibitory

Impact of vegetation types on soil organic carbon stocks SOC-S in Mediterranean natural areas

Science.gov (United States)

Parras-Alcántara, Luis; Lozano-García, Beatriz; Cantudo-Pérez, Marta

2015-04-01

Soils play a key role in the carbon geochemical cycle because they can either emit large quantities of CO2 or on the contrary they can act as a store for carbon. Agriculture and forestry are the only activities that can achieve this effect through photosynthesis and the carbon incorporation into carbohydrates (Parras-Alcántara et al., 2013). The Mediterranean evergreen oak Woodland (MEOW - dehesa) is a type of pasture with scattered evergreen and deciduous oak stands in which cereals are often grown under the tree cover. It is a system dedicated to the combined production of Iberian swine, sheep, fuel wood, coal and cork as well as to hunting. These semi-natural areas still preserve some of the primitive vegetation of the Mediterranean oak forests. The dehesa is a pasture where the herbaceous layer is comprised of either cultivated cereals such as oat, barley and wheat or native vegetation dominated by annual species, which are used as grazing resources. These Iberian open woodland rangelands (dehesas) have been studied from different points of view: hydrologically, with respect to soil organic matter content, as well as in relation to gully erosion, topographical thresholds, soil erosion and runoff production, soil degradation and management practices…etc, among others. The soil organic carbon stock capacity depends not only on abiotic factors such as the mineralogical composition and the climate, but also on soil use and management (Parras et al., 2014 and 2015). In Spanish soils, climate, use and management strongly affect the carbon variability, mainly in soils in dry Mediterranean climates characterized by low organic carbon content, weak structure and readily degradable soils. Hontoria et al. (2004) emphasized that the climate and soil use are two factors that greatly influence carbon content in the Mediterranean climate. This research sought to analyze the SOC stock (SOCS) variability in MEOW - dehesa with cereals, olive grove and Mediterranean oak forest

RadioAstron and millimetron space observatories: Multiverse models and the search for life

Science.gov (United States)

Kardashev, N. S.

2017-04-01

The transition from the radio to the millimeter and submillimeter ranges is very promising for studies of galactic nuclei, as well as detailed studies of processes related to supermassive black holes, wormholes, and possible manifestations of multi-element Universe (Multiverse) models. This is shown by observations with the largest interferometer available—RadioAstron observatory—that will be used for the scientific program forMillimetron observatory. Observations have also shown the promise of this range for studies of the formation and evolution of planetary systems and searches for manifestations of intelligent life. This is caused by the requirements to use a large amount of condensedmatter and energy in large-scale technological activities. This range can also be used efficiently in the organisation of optimal channels for the transmission of information.

DMPD: Regulation of cytokine signaling by SOCS family molecules. [Dynamic Macrophage Pathway CSML Database

Lifescience Database Archive (English)

Full Text Available 14644140 Regulation of cytokine signaling by SOCS family molecules. Fujimoto M, Nak...a T. Trends Immunol. 2003 Dec;24(12):659-66. (.png) (.svg) (.html) (.csml) Show Regulation of cytokine signaling by SOCS family... molecules. PubmedID 14644140 Title Regulation of cytokine signaling by SOCS family molec

An Overview and Comparison of Online Implementable SOC Estimation Methods for Lithium-ion Battery

DEFF Research Database (Denmark)

Meng, Jinhao; Ricco, Mattia; Luo, Guangzhao

2018-01-01

. Many SOC estimation methods have been proposed in the literature. However, only a few of them consider the real-time applicability. This paper reviews recently proposed online SOC estimation methods and classifies them into five categories. Their principal features are illustrated, and the main pros...... and cons are provided. The SOC estimation methods are compared and discussed in terms of accuracy, robustness, and computation burden. Afterward, as the most popular type of model based SOC estimation algorithms, seven nonlinear filters existing in literature are compared in terms of their accuracy...

Key KdSOC1 gene expression profiles during plantlet morphogenesis under hormone, photoperiod, and drought treatments.

Science.gov (United States)

Liu, C; Zhu, C; Zeng, H M

2016-02-11

Kalanchoe daigremontiana utilizes plantlet formation between its zigzag leaf margins as its method of asexual reproduction. In this study, K. daigremontiana SUPPRESSOR OF OVEREXPRESSION OF CONSTANS 1 (KdSOC1), a key intermediate in the transition from vegetative to asexual growth, was cloned. Furthermore, its expression profiles during plantlet formation under different environmental and hormone induction conditions were analyzed. The full-KdSOC1 cDNA sequence length was 1410 bp with 70% shared homology with Carya cathayensis SOC1. The conserved domain search of KdSOC1 showed the absence of I and C domains, which might indicate novel biological functions in K. daigremontiana. The full-KdSOC1 promoter sequence was 1401 bp long and contained multiple-hormone-responsive cis-acting elements. Hormone induction assays showed that gibberellins and salicylic acid mainly regulated KdSOC1 expression. The swift change from low to high KdSOC1 expression levels during long-day induction was accompanied by the rapid emergence of plantlets. Drought stress stimulated KdSOC1 expression in leaves both with and without plantlet formation. Together, the results suggested that KdSOC1 was closely involved in environmental stimulation signal perception and the transduction of K. daigremontiana plantlet formation. Therefore, future identification of KdSOC1 functions might reveal key information that will help elucidate the transition network between embryogenesis and organogenesis during plantlet formation.

Effects of SOC-dependent electrolyte viscosity on performance of vanadium redox flow batteries

International Nuclear Information System (INIS)

Xu, Q.; Zhao, T.S.; Zhang, C.

2014-01-01

Highlights: • The correlations of electrolyte viscosity and SOC are obtained. • Effect of SOC-dependent electrolyte viscosity is considered in this model. • This model enables a more realistic simulation of variable distributions. • It provides accurate estimations of pumping work and system efficiency. - Abstract: The viscosity of the electrolyte in vanadium redox flow batteries (VRFBs) varies during charge and discharge as the concentrations of acid and vanadium ions in the electrolyte continuously change with the state of charge (SOC). In previous VRFB models, however, the electrolyte has been treated as a constant-viscosity solution. In this work, a mass-transport and electrochemical model taking account of the effect of SOC-dependent electrolyte viscosity is developed. The comparison between the present model and the model with the constant-viscosity simplification indicates that the consideration of the SOC-dependent electrolyte viscosity enables (i) a more realistic simulation of the distributions of overpotential and current density in the electrodes, and (ii) more accurate estimations of pumping work and the system efficiency of VRFBs

Robustness of SOC Estimation Algorithms for EV Lithium-Ion Batteries against Modeling Errors and Measurement Noise

Directory of Open Access Journals (Sweden)

Xue Li

2015-01-01

Full Text Available State of charge (SOC is one of the most important parameters in battery management system (BMS. There are numerous algorithms for SOC estimation, mostly of model-based observer/filter types such as Kalman filters, closed-loop observers, and robust observers. Modeling errors and measurement noises have critical impact on accuracy of SOC estimation in these algorithms. This paper is a comparative study of robustness of SOC estimation algorithms against modeling errors and measurement noises. By using a typical battery platform for vehicle applications with sensor noise and battery aging characterization, three popular and representative SOC estimation methods (extended Kalman filter, PI-controlled observer, and H∞ observer are compared on such robustness. The simulation and experimental results demonstrate that deterioration of SOC estimation accuracy under modeling errors resulted from aging and larger measurement noise, which is quantitatively characterized. The findings of this paper provide useful information on the following aspects: (1 how SOC estimation accuracy depends on modeling reliability and voltage measurement accuracy; (2 pros and cons of typical SOC estimators in their robustness and reliability; (3 guidelines for requirements on battery system identification and sensor selections.

Enhancement of antiproliferative activity of interferons by RNA interference-mediated silencing of SOCS gene expression in tumor cells.

Science.gov (United States)

Takahashi, Yuki; Kaneda, Haruka; Takasuka, Nana; Hattori, Kayoko; Nishikawa, Makiya; Watanabe, Yoshihiko; Takakura, Yoshinobu

2008-08-01

The suppressor of cytokine signaling (SOCS) proteins, negative regulators of interferon (IFN)-induced signaling pathways, is involved in IFN resistance of tumor cells. To improve the growth inhibitory effect of IFN-beta and IFN-gamma on a murine melanoma cell line, B16-BL6, and a murine colon carcinoma cell line, Colon26 cells, SOCS-1 and SOCS-3 gene expression in tumor cells was downregulated by transfection of plasmid DNA expressing short hairpin RNA targeting one of these genes (pshSOCS-1 and pshSOCS-3, respectively). Transfection of pshSOCS-1 significantly increased the antiproliferative effect of IFN-gamma on B16-BL6 cells. However, any other combinations of plasmids and IFN had little effect on the growth of B16-BL6 cells. In addition, transfection of pshSOCS-1 and pshSOCS-3 produced little improvement in the effect of IFN on Colon26 cells. To understand the mechanism underlining these findings, the level of SOCS gene expression was measured by real time polymerase chain reaction. Addition of IFN-gamma greatly increased the SOCS-1 mRNA expression in B16-BL6 cells. Taking into account the synergistic effect of pshSOCS-1 and IFN-gamma on the growth of B16-BL6 cells, these findings suggest that IFN-gamma-induced high SOCS-1 gene expression in B16-BL6 cells significantly interferes with the antiproliferative effect of IFN-gamma. These results indicate that silencing SOCS gene expression can be an effective strategy to enhance the antitumor effect of IFN under conditions in which the SOCS gene expression is upregulated by IFN.

A multiscale framework with extended Kalman filter for lithium-ion battery SOC and capacity estimation

International Nuclear Information System (INIS)

Hu, Chao; Youn, Byeng D.; Chung, Jaesik

2012-01-01

Highlights: ► We develop a mutiscale framework with EKF to estimate SOC and capacity. ► The framework is a hybrid of coulomb counting and adaptive filtering techniques. ► It decouples SOC and capacity estimation in terms of measurement and time-scale. ► Results verify the framework achieves higher accuracy and efficiency than dual EKF. -- Abstract: State-of-charge (SOC) and capacity estimation plays an essential role in many battery-powered applications, such as electric vehicle (EV) and hybrid electric vehicle (HEV). However, commonly used joint/dual extended Kalman filter (EKF) suffers from the lack of accuracy in the capacity estimation since (i) the cell voltage is the only measurable data for the SOC and capacity estimation and updates and (ii) the capacity is very weakly linked to the cell voltage. The lack of accuracy in the capacity estimation may further reduce the accuracy in the SOC estimation due to the strong dependency of the SOC on the capacity. Furthermore, although the capacity is a slowly time-varying quantity that indicates cell state-of-health (SOH), the capacity estimation is generally performed on the same time-scale as the quickly time-varying SOC, resulting in high computational complexity. To resolve these difficulties, this paper proposes a multiscale framework with EKF for SOC and capacity estimation. The proposed framework comprises two ideas: (i) a multiscale framework to estimate SOC and capacity that exhibit time-scale separation and (ii) a state projection scheme for accurate and stable capacity estimation. Simulation results with synthetic data based on a valid cell dynamic model suggest that the proposed framework, as a hybrid of coulomb counting and adaptive filtering techniques, achieves higher accuracy and efficiency than joint/dual EKF. Results of the cycle test on Lithium-ion prismatic cells further verify the effectiveness of our framework.

The Immunohistochemical Analysis of SOCS3 Protein Identifies a Subgroup of Prostatic Cancer Biopsies With Aggressive Behavior.

Science.gov (United States)

Pierconti, Francesco; Martini, Maurizio; Cenci, Tonia; Larocca, Luigi M

Recently, we demonstrated that hypermethylation of SOCS3 determines a significant reduction of its mRNA and protein expression and identifies a subgroup of prostate cancer with aggressive behavior. In this paper, our objective was to investigate whether the immunohistochemical expression of the SOCS3 protein could represent an alternative method to molecular analysis for the individualization of aggressive prostate carcinoma. We analyzed the SOCS3 immunohistochemical expression in 65 patients undergoing biopsies at the Institute of Urology of our hospital between September 2011 and October 2011 (median age, 66.4 y; range, 50 to 73 y), and in 35 cases, a subset of 65 cases originally used for the immunohistochemical study, we studied the methylation status of the SOCS3 promoter. We found that the percentage of cases with SOCS3 negativity (-) or with SOCS3 weak staining in <50% of the neoplastic glands (+/-) correlated to the worst prognosis in terms of the Gleason score (P=0.0001; Fisher's exact test), the pT stage (P=0.012; Fisher's exact test), and progression-free survival (P=0.0334; hazard ratio, 0.34; and 95% confidence interval, from 0.1261 to 0.9188). Moreover, some cases with an SOCS3 unmethylated pattern showed SOCS3-negative immunostaining (-) or SOCS3-negative glands with weak cytoplasmatic staining in <50% of the neoplastic glands (+/-). Our data suggest that in prostatic cancer biopsies, the immunohistochemical analysis of SOCS3 protein expression may provide a method that is less expensive and easier to apply than SOCS3 methylation analysis for the distinction of a subgroup of prostate cancer with a more aggressive behavior.

Purification of SOCS (Suppressor of Cytokine Signaling) SH2 Domains for Structural and Functional Studies.

Science.gov (United States)

Liau, Nicholas P D; Laktyushin, Artem; Babon, Jeffrey J

2017-01-01

Src Homology 2 (SH2) domains are protein domains which have a high binding affinity for specific amino acid sequences containing a phosphorylated tyrosine residue. The Suppressors of Cytokine Signaling (SOCS) proteins use an SH2 domain to bind to components of certain cytokine signaling pathways to downregulate the signaling cascade. The recombinantly produced SH2 domains of various SOCS proteins have been used to undertake structural and functional studies elucidating the method of how such targeting occurs. Here, we describe the protocol for the recombinant production and purification of SOCS SH2 domains, with an emphasis on SOCS3.

Model for the coma of Comet Halley, based on the Astron ultraviolet spectrophotometry

International Nuclear Information System (INIS)

Boiarchuk, A.A.; Grinin, V.P.; Petrov, P.P.; Sheikhet, A.I.; Zvereva, A.M.

1986-01-01

The development of a model of the Comet Halley coma from spectral and photometric data is described. Spectra in the 1500-3500 A range and photometric scans at the 3085 A and 2190 A in the (0-0) band of the OH and CO(+) molecules were obtained by the UV telescope of the satellite Astron on December 3, 13, and 23, 1985. Surface-brightness profiles of the coma in the (0-0) band of OH, NH, and CS molecules are derived. The source and formation of these molecules, the lifetime of their radicals, the radial velocity of their parent molecules, and the water-molecule sublimation rate are computed and examined. The basic characteristics of the comet observed from the UV data are compared to the properties of other comets. It is observed that Comet Halley is similar to other large short-period comets. 29 references

SoC Estimation for Lithium-ion Batteries: Review and Future Challenges

Directory of Open Access Journals (Sweden)

Juan Pablo Rivera-Barrera

2017-11-01

Full Text Available Energy storage emerged as a top concern for the modern cities, and the choice of the lithium-ion chemistry battery technology as an effective solution for storage applications proved to be a highly efficient option. State of charge (SoC represents the available battery capacity and is one of the most important states that need to be monitored to optimize the performance and extend the lifetime of batteries. This review summarizes the methods for SoC estimation for lithium-ion batteries (LiBs. The SoC estimation methods are presented focusing on the description of the techniques and the elaboration of their weaknesses for the use in on-line battery management systems (BMS applications. SoC estimation is a challenging task hindered by considerable changes in battery characteristics over its lifetime due to aging and to the distinct nonlinear behavior. This has led scholars to propose different methods that clearly raised the challenge of establishing a relationship between the accuracy and robustness of the methods, and their low complexity to be implemented. This paper publishes an exhaustive review of the works presented during the last five years, where the tendency of the estimation techniques has been oriented toward a mixture of probabilistic techniques and some artificial intelligence.

Synthesis of highly monodispersed Ga-soc-MOF hollow cubes, colloidosomes and nanocomposites

KAUST Repository

Cai, Xuechao

2016-07-06

Ga-soc-MOF hollow cubes with an average size of about 300 nm were prepared by a polyvinylpyrrolidone (PVP) assisted acid etching process. Colloidosomes with sizes of around 5-10 mu m composed of single-layer tetrakaidecahedron building blocks (BBs) were synthesized for the first time. Au@Ga-soc-MOF nanocomposites with excellent catalytic properties were obtained.

Synthesis of highly monodispersed Ga-soc-MOF hollow cubes, colloidosomes and nanocomposites

KAUST Repository

Cai, Xuechao; Deng, Xiaoran; Xie, Zhongxi; Bao, Shouxin; Shi, Yanshu; Lin, Jun; Pang, Maolin; Eddaoudi, Mohamed

2016-01-01

Ga-soc-MOF hollow cubes with an average size of about 300 nm were prepared by a polyvinylpyrrolidone (PVP) assisted acid etching process. Colloidosomes with sizes of around 5-10 mu m composed of single-layer tetrakaidecahedron building blocks (BBs) were synthesized for the first time. Au@Ga-soc-MOF nanocomposites with excellent catalytic properties were obtained.

A refração atmosférica e os seus problemas nas observações astronômicas

OpenAIRE

Guilherme de Almeida

2014-01-01

http://dx.doi.org/10.5007/2175-7941.2014v31n2p410 Quando apontamos um telescópio na direção de um astro, estamos quase sempre a apontar numa direção mais acima, devido à refração da luz que atravessa a atmosfera da Terra. O fenômeno da refração atmosférica tem diversas implicações prejudiciais nas observações astronômicas, que serão objeto deste artigo.

Boosted gain programmable OpAmp with embedded gain monitor for dependable SoCs

NARCIS (Netherlands)

Wan, J.; Kerkhoff, Hans G.

2011-01-01

SoCs used in safety-critical applications need to be dependable. However in the deep-submicron region, different kinds of aging effects like negative bias temperature instability (NBTI) make the SoCs, especially the analog/mixed-signal parts, undependable. In this paper, a dependability-improved

Low-Power Differential SRAM design for SOC Based on the 25-um Technology

Science.gov (United States)

Godugunuri, Sivaprasad; Dara, Naveen; Sambasiva Nayak, R.; Nayeemuddin, Md; Singh, Yadu, Dr.; Veda, R. N. S. Sunil

2017-08-01

In recent, the SOC styles area unit the vast complicated styles in VLSI these SOC styles having important low-power operations problems, to comprehend this we tend to enforced low-power SRAM. However these SRAM Architectures critically affects the entire power of SOC and competitive space. To beat the higher than disadvantages, during this paper, a low-power differential SRAM design is planned. The differential SRAM design stores multiple bits within the same cell, operates at minimum in operation low-tension and space per bit. The differential SRAM design designed supported the 25-um technology using Tanner-EDA Tool.

Socs36E Controls Niche Competition by Repressing MAPK Signaling in the Drosophila Testis.

Directory of Open Access Journals (Sweden)

Marc Amoyel

2016-01-01

Full Text Available The Drosophila testis is a well-established system for studying stem cell self-renewal and competition. In this tissue, the niche supports two stem cell populations, germ line stem cells (GSCs, which give rise to sperm, and somatic stem cells called cyst stem cells (CySCs, which support GSCs and their descendants. It has been established that CySCs compete with each other and with GSCs for niche access, and mutations have been identified that confer increased competitiveness to CySCs, resulting in the mutant stem cell and its descendants outcompeting wild type resident stem cells. Socs36E, which encodes a negative feedback inhibitor of the JAK/STAT pathway, was the first identified regulator of niche competition. The competitive behavior of Socs36E mutant CySCs was attributed to increased JAK/STAT signaling. Here we show that competitive behavior of Socs36E mutant CySCs is due in large part to unbridled Mitogen-Activated Protein Kinase (MAPK signaling. In Socs36E mutant clones, MAPK activity is elevated. Furthermore, we find that clonal upregulation of MAPK in CySCs leads to their outcompetition of wild type CySCs and of GSCs, recapitulating the Socs36E mutant phenotype. Indeed, when MAPK activity is removed from Socs36E mutant clones, they lose their competitiveness but maintain self-renewal, presumably due to increased JAK/STAT signaling in these cells. Consistently, loss of JAK/STAT activity in Socs36E mutant clones severely impairs their self-renewal. Thus, our results enable the genetic separation of two essential processes that occur in stem cells. While some niche signals specify the intrinsic property of self-renewal, which is absolutely required in all stem cells for niche residence, additional signals control the ability of stem cells to compete with their neighbors. Socs36E is node through which these processes are linked, demonstrating that negative feedback inhibition integrates multiple aspects of stem cell behavior.

Comparison Study on the Battery SoC Estimation with EKF and UKF Algorithms

Directory of Open Access Journals (Sweden)

Hongwen He

2013-09-01

Full Text Available The battery state of charge (SoC, whose estimation is one of the basic functions of battery management system (BMS, is a vital input parameter in the energy management and power distribution control of electric vehicles (EVs. In this paper, two methods based on an extended Kalman filter (EKF and unscented Kalman filter (UKF, respectively, are proposed to estimate the SoC of a lithium-ion battery used in EVs. The lithium-ion battery is modeled with the Thevenin model and the model parameters are identified based on experimental data and validated with the Beijing Driving Cycle. Then space equations used for SoC estimation are established. The SoC estimation results with EKF and UKF are compared in aspects of accuracy and convergence. It is concluded that the two algorithms both perform well, while the UKF algorithm is much better with a faster convergence ability and a higher accuracy.

A step toward 'plug and play' robotics with SoC technology

DEFF Research Database (Denmark)

Sørensen, Anders Stengaard; Falsig, Simon; Ugilt, Rolf

p, li { white-space: pre-wrap; } This article describe our progress toward simplifying and streamlining the low level systems integration of experimental robots, combining a System on Chip (SoC) approach with conventional modular approaches. The combined approach has increased flexibility, improved...... the embedded integration, and decreased the complexity of programming, compared to conventional modular approaches. We show the impact of the SoC approach in a simple demonstration and teaching model of a walking robot....

Study on SOC wavelet analysis for LiFePO4 battery

Science.gov (United States)

Liu, Xuepeng; Zhao, Dongmei

2017-08-01

Improving the prediction accuracy of SOC can reduce the complexity of the conservative and control strategy of the strategy such as the scheduling, optimization and planning of LiFePO4 battery system. Based on the analysis of the relationship between the SOC historical data and the external stress factors, the SOC Estimation-Correction Prediction Model based on wavelet analysis is established. Using wavelet neural network prediction model is of high precision to achieve forecast link, external stress measured data is used to update parameters estimation in the model, implement correction link, makes the forecast model can adapt to the LiFePO4 battery under rated condition of charge and discharge the operating point of the variable operation area. The test results show that the method can obtain higher precision prediction model when the input and output of LiFePO4 battery are changed frequently.

Fundamentals of IP and SoC security design, verification, and debug

CERN Document Server

Ray, Sandip; Sur-Kolay, Susmita

2017-01-01

This book is about security in embedded systems and it provides an authoritative reference to all aspects of security in system-on-chip (SoC) designs. The authors discuss issues ranging from security requirements in SoC designs, definition of architectures and design choices to enforce and validate security policies, and trade-offs and conflicts involving security, functionality, and debug requirements. Coverage also includes case studies from the “trenches” of current industrial practice in design, implementation, and validation of security-critical embedded systems. Provides an authoritative reference and summary of the current state-of-the-art in security for embedded systems, hardware IPs and SoC designs; Takes a "cross-cutting" view of security that interacts with different design and validation components such as architecture, implementation, verification, and debug, each enforcing unique trade-offs; Includes high-level overview, detailed analysis on implementation, and relevant case studies on desi...

The Meanings of Astronomical Observation: An Analysis on the Basis of Relationship with Knowledge. (Spanish Title: Los Sentidos de la Observación Astronómica: un Análisis sobre la Base de la Relación con el Saber.) Os Sentidos da Observação Astronômica: Uma Análise com Base na Relação com o Saber

Science.gov (United States)

Klein, Alberto Eduardo; de Mello Arruda, Sergio; Meneghello Passos, Marinez; Vinicius Domenes Zapparoli, Ferdinando

2010-12-01

This article presents results of a research which aimed to understand the meanings that people construct for astronomical observation. The subjects, students and school teachers, initially received some instruction on how to view astronomical objects through the telescope. After the observation was realized, they were interviewed. The data analysis allowed the creation of 12 categories, later interpreted on the basis of relationship with knowledge (relation to the world, with himself and with others), as presented by Bernard Charlot. Este artículo presenta los resultados de una investigación que tuvo como objetivo comprender los sentidos que las personas construyen para la observación astronómica. Los sujetos, los estudiantes y maestros de escuela, recibieron inicialmente algunas instrucciones sobre cómo ver los objetos astronómicos a través del telescopio. Al término de la observación, fueron entrevistados. El análisis de datos permitió la creación de 12 categorías que más tarde fueron interpretadas sobre la base de la relación con el conocimiento (relación con el mundo, consigo mismo y con los demás), tal como presentado por Bernard Charlot. Este artigo apresenta resultados de uma pesquisa que objetivou entender quais os sentidos que as pessoas constroem para a observação astronômica. Os sujeitos da pesquisa, estudantes e professores do ensino médio, receberam inicialmente alguma instrução sobre como visualizar os objetos astronômicos através do telescópio. Após a realização da observação, eles foram entrevistados. A análise dos dados permitiu a elaboração de 12 categorias que foram posteriormente interpretadas com base nas relações com o saber (relação com o mundo, consigo mesmo e com o outro), conforme apresentadas por Bernard Charlot.

Suppressor of cytokine signaling (SOCS genes are silenced by DNA hypermethylation and histone deacetylation and regulate response to radiotherapy in cervical cancer cells.

Directory of Open Access Journals (Sweden)

Moon-Hong Kim

Full Text Available Suppressor of cytokine signaling (SOCS family is an important negative regulator of cytokine signaling and deregulation of SOCS has been involved in many types of cancer. All cervical cancer cell lines tested showed lower expression of SOCS1, SOCS3, and SOCS5 than normal tissue or cell lines. The immunohistochemistry result for SOCS proteins in human cervical tissue also confirmed that normal tissue expressed higher level of SOCS proteins than neighboring tumor. Similar to the regulation of SOCS in other types of cancer, DNA methylation contributed to SOCS1 downregulation in CaSki, ME-180, and HeLa cells. However, the expression of SOCS3 or SOCS5 was not recovered by the inhibition of DNA methylation. Histone deacetylation may be another regulatory mechanism involved in SOCS1 and SOCS3 expression, however, SOCS5 expression was neither affected by DNA methylation nor histone deacetylation. Ectopic expression of SOCS1 or SOCS3 conferred radioresistance to HeLa cells, which implied SOCS signaling regulates the response to radiation in cervical cancer. In this study, we have shown that SOCS expression repressed by, in part, epigenetically and altered SOCS1 and SOCS3 expression could contribute to the radiosensitive phenotype in cervical cancer.

A refração atmosférica e os seus problemas nas observações astronômicas

Directory of Open Access Journals (Sweden)

Guilherme de Almeida

2014-05-01

Full Text Available http://dx.doi.org/10.5007/2175-7941.2014v31n2p410 Quando apontamos um telescópio na direção de um astro, estamos quase sempre a apontar numa direção mais acima, devido à refração da luz que atravessa a atmosfera da Terra. O fenômeno da refração atmosférica tem diversas implicações prejudiciais nas observações astronômicas, que serão objeto deste artigo.

A 0.7-V 17.4- μ W 3-lead wireless ECG SoC.

Science.gov (United States)

Khayatzadeh, Mahmood; Zhang, Xiaoyang; Tan, Jun; Liew, Wen-Sin; Lian, Yong

2013-10-01

This paper presents a fully integrated sub-1 V 3-lead wireless ECG System-on-Chip (SoC) for wireless body sensor network applications. The SoC includes a two-channel ECG front-end with a driven-right-leg circuit, an 8-bit SAR ADC, a custom-designed 16-bit microcontroller, two banks of 16 kb SRAM, and a MICS band transceiver. The microcontroller and SRAM blocks are able to operate at sub-/near-threshold regime for the best energy consumption. The proposed SoC has been implemented in a standard 0.13- μ m CMOS process. Measurement results show the microcontroller consumes only 2.62 pJ per instruction at 0.35 V . Both microcontroller and memory blocks are functional down to 0.25 V. The entire SoC is capable of working at single 0.7-V supply. At the best case, it consumes 17.4 μ W in heart rate detection mode and 74.8 μW in raw data acquisition mode under sampling rate of 500 Hz. This makes it one of the best ECG SoCs among state-of-the-art biomedical chips.

Mapping SOC (Soil Organic Carbon) using LiDAR-derived vegetation indices in a random forest regression model

Science.gov (United States)

Will, R. M.; Glenn, N. F.; Benner, S. G.; Pierce, J. L.; Spaete, L.; Li, A.

2015-12-01

Quantifying SOC (Soil Organic Carbon) storage in complex terrain is challenging due to high spatial variability. Generally, the challenge is met by transforming point data to the entire landscape using surrogate, spatially-distributed, variables like elevation or precipitation. In many ecosystems, remotely sensed information on above-ground vegetation (e.g. NDVI) is a good predictor of below-ground carbon stocks. In this project, we are attempting to improve this predictive method by incorporating LiDAR-derived vegetation indices. LiDAR provides a mechanism for improved characterization of aboveground vegetation by providing structural parameters such as vegetation height and biomass. In this study, a random forest model is used to predict SOC using a suite of LiDAR-derived vegetation indices as predictor variables. The Reynolds Creek Experimental Watershed (RCEW) is an ideal location for a study of this type since it encompasses a strong elevation/precipitation gradient that supports lower biomass sagebrush ecosystems at low elevations and forests with more biomass at higher elevations. Sagebrush ecosystems composed of Wyoming, Low and Mountain Sagebrush have SOC values ranging from .4 to 1% (top 30 cm), while higher biomass ecosystems composed of aspen, juniper and fir have SOC values approaching 4% (top 30 cm). Large differences in SOC have been observed between canopy and interspace locations and high resolution vegetation information is likely to explain plot scale variability in SOC. Mapping of the SOC reservoir will help identify underlying controls on SOC distribution and provide insight into which processes are most important in determining SOC in semi-arid mountainous regions. In addition, airborne LiDAR has the potential to characterize vegetation communities at a high resolution and could be a tool for improving estimates of SOC at larger scales.

Research on State-of-Charge (SOC) estimation using current integration based on temperature compensation

Science.gov (United States)

Yin, J.; Shen, Y.; Liu, X. T.; Zeng, G. J.; Liu, D. C.

2017-11-01

The traditional current integral method for the state-of-charge (SOC) estimation has an unusable estimation accuracy because of the current measuring error. This paper proposed a closed-loop temperature compensation method to improve the SOC estimation accuracy of current integral method by eliminating temperature drift. Through circuit simulation result in Multisim, the stability of current measuring accuracy is improved by more than 10 times. In a designed 70 charge-discharge experimental circle, the SOC estimation error with temperature compensation had 30 times less than error in normal situation without compensation.

The Double–Double Radio Galaxy 3C293 S. A. Joshi1,∗ , S. Nandi2 ...

Indian Academy of Sciences (India)

prominent hot-spot in the north-western lobe as well as the age of the inner double structure suggests that the interruption of jet activity is <. ∼0.1 Myr. References. Beswick R.J., Peck A.B., Taylor G.B., Giovannini G. 2004, Mon. Not. R. Astron. Soc., 352, 49. Joshi S.A., Nandi S., Saikia D.J., Ishwara-Chandra C.H., Konar C.

Suppressor of cytokine signaling 1 (SOCS1) limits NFkappaB signaling by decreasing p65 stability within the cell nucleus.

Science.gov (United States)

Strebovsky, Julia; Walker, Patrick; Lang, Roland; Dalpke, Alexander H

2011-03-01

Suppressor of cytokine signaling (SOCS) proteins are inhibitors of cytoplasmic Janus kinases (Jak) and signal transducer and activator of transcription (STAT) signaling pathways. Previously the authors surprisingly observed that SOCS1 translocated into the nucleus, which was because of the presence of a nuclear localization sequence. This report now hypothesizes that SOCS1 mediates specific functions within the nuclear compartment because it is instantly transported into the nucleus, as shown by photoactivation and live cell imaging in human HEK293 cells. The NFκB component p65 is identified as an interaction partner for SOCS1 but not for other members of the SOCS family. SOCS1 bound to p65 only within the nucleus. By means of its SOCS box domain, SOCS1 operated as a ubiquitin ligase, leading to polyubiquitination and proteasomal degradation of nuclear p65. Thus, SOCS1 limited prolonged p65 signaling and terminated expression of NFκB inducible genes. Using mutants that lack either nuclear translocation or a functional SOCS box, this report identifies genes that are regulated in a manner dependent on the nuclear availability of SOCS1. Data show that beyond its receptor-proximal function in Jak/STAT signaling, SOCS1 also regulates the duration of NFκB signaling within the cell nucleus, thus exerting a heretofore unrecognized function.

DMPD: Regulation of innate immunity by suppressor of cytokine signaling (SOCS)proteins. [Dynamic Macrophage Pathway CSML Database

Lifescience Database Archive (English)

Full Text Available 18406369 Regulation of innate immunity by suppressor of cytokine signaling (SOCS)proteins...svg) (.html) (.csml) Show Regulation of innate immunity by suppressor of cytokine signaling (SOCS)proteins. ...PubmedID 18406369 Title Regulation of innate immunity by suppressor of cytokine signaling (SOCS)proteins

A Bayesian Belief Network framework to predict SOC stock change: the Veneto region (Italy) case study

Science.gov (United States)

Dal Ferro, Nicola; Quinn, Claire Helen; Morari, Francesco

2017-04-01

A key challenge for soil scientists is predicting agricultural management scenarios that combine crop productions with high standards of environmental quality. In this context, reversing the soil organic carbon (SOC) decline in croplands is required for maintaining soil fertility and contributing to mitigate GHGs emissions. Bayesian belief networks (BBN) are probabilistic models able to accommodate uncertainty and variability in the predictions of the impacts of management and environmental changes. By linking multiple qualitative and quantitative variables in a cause-and-effect relationships, BBNs can be used as a decision support system at different spatial scales to find best management strategies in the agroecosystems. In this work we built a BBN to model SOC dynamics (0-30 cm layer) in the low-lying plain of Veneto region, north-eastern Italy, and define best practices leading to SOC accumulation and GHGs (CO2-equivalent) emissions reduction. Regional pedo-climatic, land use and management information were combined with experimental and modelled data on soil C dynamics as natural and anthropic key drivers affecting SOC stock change. Moreover, utility nodes were introduced to determine optimal decisions for mitigating GHGs emissions from croplands considering also three different IPCC climate scenarios. The network was finally validated with real field data in terms of SOC stock change. Results showed that the BBN was able to model real SOC stock changes, since validation slightly overestimated SOC reduction (+5%) at the expenses of its accumulation. At regional level, probability distributions showed 50% of SOC loss, while only 17% of accumulation. However, the greatest losses (34%) were associated with low reduction rates (100-500 kg C ha-1 y-1), followed by 33% of stabilized conditions (-100 < SOC < 100 kg ha-1 y-1). Land use management (especially tillage operations and soil cover) played a primary role to affect SOC stock change, while climate conditions

SOCS2 deletion protects against hepatic steatosis but worsens insulin resistance in high-fat-diet-fed mice

DEFF Research Database (Denmark)

Zadjali, Fahad; Santana-Farre, Ruyman; Vesterlund, Mattias

2012-01-01

in the development of diet-induced hepatic steatosis and insulin resistance. SOCS2-knockout (SOCS2(-/-)) mice and wild-type littermates were fed for 4 mo with control or high-fat diet, followed by assessment of insulin sensitivity, hepatic lipid content, and expression of inflammatory cytokines. SOCS2(-/-) mice...

A3. 408 MHz radio continuum flux at mod(b) 0

International Nuclear Information System (INIS)

Haslam, C.G.T.

1983-01-01

The map shows the radio continuum brightness at a frequency of 408 MHz (lambda73 cm). The atlas of the all-sky survey published by Haslam et al. contains data from four surveys, made with the Jodrell Bank Mk I (anticenter region), the Bonn 100-m (-8 0 0 ), the Parkes 64-m (southern sky), and the Jodrell Bank Mk I A (north celestial pole region) telescopes. The respective references for the four component surveys are Haslam, Quigley, and Salter, 1970, Mon. Not. R. Astron. Soc. 147, 405; Haslam, Wilson, Graham, and Hunt, 1974, Astron. Astrophys. Suppl. Ser. 13, 359; Haslam, Wilson, Cooke, Cleary, Graham, Wilelebinski, and Day, 1975, Proc. ASA 2 (6), 331; and Haslam, Klein, Salter, Stoffel, Wilson, Cleary, Cooke, and Thomasson, 1981, Astron. Astrophys. 100, 209. The angular resolution of the original data base is 0 0 .85. For the map in galactic coordinates produced here, the data have been smoothed and placed on a 2 0 rectangular grid. The contours represent brightness temperature labelled in Kelvins. (Auth.)

SOCS5 is expressed in primary B and T lymphoid cells but is dispensable for lymphocyte production and function

DEFF Research Database (Denmark)

Brender, Christine; Columbus, Ruth; Metcalf, Donald

2004-01-01

the importance of SOCS5 in T helper cell responses. Unexpectedly, SOCS5-deficient CD4 T cells showed no abnormalities in Th1/Th2 differentiation and Socs5(-/-) mice showed normal resistance to infection with Leishmania major. Therefore, although SOCS5 is expressed in primary B and T cells, it appears...

Variation tolerant SoC design

Science.gov (United States)

Kozhikkottu, Vivek J.

performance distribution. This task is particularly complex and challenging due to the inter-dependencies between components' execution, indirect effects of shared resources, and interactions between multiple system-level "execution paths". We argue that accurate variation-aware performance analysis requires Monte-Carlo based repeated system execution. Our proposed analysis framework leverages emulation to significantly speedup performance analysis without sacrificing the generality and accuracy achieved by Monte-Carlo based simulations. Our experiments show performance improvements of around 60x compared to state-of-the-art hardware-software co-simulation tools and also underscore the framework's potential to enable variation-aware design and exploration at the system level. Our second contribution addresses the problem of designing variation-tolerant SoCs using recovery based design, a popular circuit design paradigm that addresses variations by eliminating guard-bands and operating circuits at close to "zero margins" while detecting and recovering from timing errors. While previous efforts have demonstrated the potential benefits of recovery based design, we identify several challenges that need to be addressed in order to apply this technique to SoCs. We present a systematic design framework to apply recovery based design at the system level. We propose to partition SoCs into "recovery islands", wherein each recovery island consists of one or more SoC components that can recover independent of the rest of the SoC. We present a variation-aware design methodology that partitions a given SoC into recovery islands and computes the optimal operating points for each island, taking into account the various trade-offs involved. Our experiments demonstrate that the proposed design framework achieves an average of 32% energy savings over conventional worst-case designs, with negligible losses in performance. The third contribution of this thesis introduces disproportionate

Biological evidence that SOCS-2 can act either as an enhancer or suppressor of growth hormone signaling

DEFF Research Database (Denmark)

Greenhalgh, Christopher J; Metcalf, Donald; Thaus, Anne L

2002-01-01

Suppressor of cytokine signaling (SOCS)-2 is a member of a family of intracellular proteins implicated in the negative regulation of cytokine signaling. The generation of SOCS-2-deficient mice, which grow to one and a half times the size of their wild-type littermates, suggests that SOCS-2 may at...

Advanced Technology for Ultra-Low Power System-on-Chip (SoC)

Science.gov (United States)

2017-06-01

was proposed for lower power applications with Ioff=10pA/μm and VDD=0.5V. In this project, the optimized structure shows great potential in both Lg...AFRL-RY-WP-TR-2017-0115 ADVANCED TECHNOLOGY FOR ULTRA-LOW POWER SYSTEM-ON-CHIP (SoC) Jason Woo, Weicong Li, and Peng Lu University of California...September 2015 – 31 March 2017 4. TITLE AND SUBTITLE ADVANCED TECHNOLOGY FOR ULTRA-LOW POWER SYSTEM-ON- CHIP (SoC) 5a. CONTRACT NUMBER FA8650-15-1-7574 5b

DMPD: Suppressor of cytokine signaling (SOCS) 2, a protein with multiple functions. [Dynamic Macrophage Pathway CSML Database

Lifescience Database Archive (English)

Full Text Available 17070092 Suppressor of cytokine signaling (SOCS) 2, a protein with multiple function...Epub 2006 Oct 27. (.png) (.svg) (.html) (.csml) Show Suppressor of cytokine signaling (SOCS) 2, a protein with multiple function...SOCS) 2, a protein with multiple functions. Authors Rico-Bautista E, Flores-Morales A, Fernandez-Perez L. Pu

NTP Radioisotopes SOC Ltd

International Nuclear Information System (INIS)

Letule, T.

2017-01-01

NTP Radioisotopes SOC Ltd, a wholly owned subsidiary of the South African Nuclear Energy Corporation (NECSA). Supplies around 20% of the world's medical radioisotopes used. NTP is a pioneer in the introduction and growth of nuclear medicine as in South Africa. Nuclear medicine is the medical specialty that involves the use of radioactive isotopes in the diagnosis and treatment of diseases. Nuclear medicine contributes to enhancing the lives of the society. There is a compelling need for nuclear medicine to be promoted and utilized in the rest of Africa, due to the increasing prevalence of cancer. Cancer is rapidly becoming a public health crisis in low-income and middle-income countries. In sub-Saharan Africa, patients often present with advanced disease

Increased linear bone growth by GH in the absence of SOCS2 is independent of IGF-1.

Science.gov (United States)

Dobie, Ross; Ahmed, Syed F; Staines, Katherine A; Pass, Chloe; Jasim, Seema; MacRae, Vicky E; Farquharson, Colin

2015-11-01

Growth hormone (GH) signaling is essential for postnatal linear bone growth, but the relative importance of GHs actions on the liver and/or growth plate cartilage remains unclear. The importance of liver derived insulin like-growth factor-1 (IGF-1) for endochondral growth has recently been challenged. Here, we investigate linear growth in Suppressor of Cytokine Signaling-2 (SOCS2) knockout mice, which have enhanced growth despite normal systemic GH/IGF-1 levels. Wild-type embryonic ex vivo metatarsals failed to exhibit increased linear growth in response to GH, but displayed increased Socs2 transcript levels (P growth over a 12 day period. Despite this increase, IGF-1 transcript and protein levels were not increased in response to GH. In accordance with these data, IGF-1 levels were unchanged in GH-challenged postnatal Socs2(-/-) conditioned medium despite metatarsals showing enhanced linear growth. Growth-plate Igf1 mRNA levels were not elevated in juvenile Socs2(-/-) mice. GH did however elevate IGF-binding protein 3 levels in conditioned medium from GH challenged metatarsals and this was more apparent in Socs2(-/-) metatarsals. GH did not enhance the growth of Socs2(-/-) metatarsals when the IGF receptor was inhibited, suggesting that IGF receptor mediated mechanisms are required. IGF-2 may be responsible as IGF-2 promoted metatarsal growth and Igf2 expression was elevated in Socs2(-/-) (but not WT) metatarsals in response to GH. These studies emphasise the critical importance of SOCS2 in regulating GHs ability to promote bone growth. Also, GH appears to act directly on the metatarsals of Socs2(-/-) mice, promoting growth via a mechanism that is independent of IGF-1. © 2014 The Authors. Journal of Cellular Physiology Published by Wiley Periodicals, Inc.

Enfoque CTSA no ensino de astronomia: uma investigação de possibilidades por meio da astronáutica

OpenAIRE

Teixeira, Claudio Henrique da Silva [UNESP

2013-01-01

O ensino da astronomia e astronáutica no Brasil, referente à formação de professores, extensão universitária e currículo do ensino básico, pode ter um novo enfoque e uma nova ênfase dada dos seus conteúdos e abordagens. Desde a década de sessenta, currículos de ensino de ciências com ênfase em CTSA - ciência, tecnologia, sociedade e ambiente - vêm sendo desenvolvidos no mundo inteiro. Tais currículos apresentam como objetivo central preparar os alunos para o exercício da cidadania e caracteri...

SOCS3 promoter hypermethylation is a favorable prognosticator and a novel indicator for G-CIMP-positive GBM patients.

Science.gov (United States)

Feng, Ying; Wang, Zheng; Bao, Zhaoshi; Yan, Wei; You, Gan; Wang, Yinyan; Hu, Huimin; Zhang, Wei; Zhang, Quangeng; Jiang, Tao

2014-01-01

Hypermethylation of the suppressor of cytokine signaling 3(SOCS3) promoter has been reported to predict a poor prognosis in several cancers including glioblastoma multiforme (GBM). We explored the function of SOCS3 promoter hypermethylation in GBM cohorts, including analysis of the CpG island methylator phenotype (CIMP), when a large number of gene loci are simultaneously hypermethylated. A whole genome promoter methylation profile was performed in a cohort of 33 GBM samples, with 13 long-term survivors (LTS; overall survival ≥ 18 months) and 20 short-term survivors (STS; overall survival ≤ 9 months). The SOCS3 promoter methylation status was compared between the two groups. In addition, we investigated the relationship of SOCS3 promoter methylation and G-CIMP status. Interestingly, in our present study, we found that SOCS3 promoter methylation was statistically significantly higher in the 13 LTS than that in the 20 STS. Furthermore, high SOCS3 promoter methylation detected via pyro-sequencing predicted a better prognosis in an independent cohort containing 62 GBM patients. This correlation was validated by the dataset from the Cancer Genome Atlas(TCGA) and the Chinese Cancer Genome Atlas(CGGA). In addition, we found that hypermethylation of the SOCS3 promoter was tightly associated with the G-CIMP-positive GBM patients. Using a total of 359 clinical samples, we demonstrate that SOCS3 promoter hypermethylation status has a favorable prognostic value in GBM patients because of whole genome methylation status. Particularly, the hypermethylation of the SOCS3 promoter indicates positive G-CIMP status.

SOCS3 promoter hypermethylation is a favorable prognosticator and a novel indicator for G-CIMP-positive GBM patients.

Directory of Open Access Journals (Sweden)

Ying Feng

Full Text Available Hypermethylation of the suppressor of cytokine signaling 3(SOCS3 promoter has been reported to predict a poor prognosis in several cancers including glioblastoma multiforme (GBM. We explored the function of SOCS3 promoter hypermethylation in GBM cohorts, including analysis of the CpG island methylator phenotype (CIMP, when a large number of gene loci are simultaneously hypermethylated.A whole genome promoter methylation profile was performed in a cohort of 33 GBM samples, with 13 long-term survivors (LTS; overall survival ≥ 18 months and 20 short-term survivors (STS; overall survival ≤ 9 months. The SOCS3 promoter methylation status was compared between the two groups. In addition, we investigated the relationship of SOCS3 promoter methylation and G-CIMP status.Interestingly, in our present study, we found that SOCS3 promoter methylation was statistically significantly higher in the 13 LTS than that in the 20 STS. Furthermore, high SOCS3 promoter methylation detected via pyro-sequencing predicted a better prognosis in an independent cohort containing 62 GBM patients. This correlation was validated by the dataset from the Cancer Genome Atlas(TCGA and the Chinese Cancer Genome Atlas(CGGA. In addition, we found that hypermethylation of the SOCS3 promoter was tightly associated with the G-CIMP-positive GBM patients.Using a total of 359 clinical samples, we demonstrate that SOCS3 promoter hypermethylation status has a favorable prognostic value in GBM patients because of whole genome methylation status. Particularly, the hypermethylation of the SOCS3 promoter indicates positive G-CIMP status.

Correct-by-construction approaches for SoC design

CERN Document Server

Sinha, Roopak; Basu, Samik

2013-01-01

This book describes an approach for designing Systems-on-Chip such that the system meets precise mathematical requirements. The methodologies presented enable embedded systems designers to reuse intellectual property (IP) blocks from existing designs in an efficient, reliable manner, automatically generating correct SoCs from multiple, possibly mismatching, components.

CKP Hierarchy, Bosonic Tau Function and Bosonization Formulae

Directory of Open Access Journals (Sweden)

Johan W. van de Leur

2012-06-01

Full Text Available We develop the theory of CKP hierarchy introduced in the papers of Kyoto school [Date E., Jimbo M., Kashiwara M., Miwa T., J. Phys. Soc. Japan 50 (1981, 3806-3812] (see also [Kac V.G., van de Leur J.W., Adv. Ser. Math. Phys., Vol. 7, World Sci. Publ., Teaneck, NJ, 1989, 369-406]. We present appropriate bosonization formulae. We show that in the context of the CKP theory certain orthogonal polynomials appear. These polynomials are polynomial both in even and odd (in Grassmannian sense variables.

Mapping SOC in a river catchment by integrating laboratory spectra wavelength with remote sensing spectra

DEFF Research Database (Denmark)

Peng, Yi; Xiong, Xiong; Knadel, Maria

There is potential to use soil ·-proximal and remote sensing derived spectra concomitantly to develop soil organic carbon (SOC) models. Yet mixing spectral data from different sources and technologies to improve soil models is still in its infancy. The objective of this study was to incorporate...... soil spectral features indicative of SOC from laboratory visible near-infrared reflectance (vis-NlR) spectra and incorporate them with remote sensing (RS) images to improve predictions of top SOC in the Skjem river catchment, Denmark. The secondary objective was to improve prediction results...

Erratum: Spiral structure in the accretion disc of the binary IP Pegasi

Science.gov (United States)

Steeghs, D.; Harlaftis, E. T.; Horne, Keith

1998-05-01

The paper `Spiral structure in the accretion disc of the binary IP Pegasi' was published in Mon. Not. R. Astron. Soc. 290, L28-L32 (1997). Figs 1 and 2 of the paper (grey-scale images) did not reproduce well, and are reprinted here (Fig. 1 overleaf). Colour versions of the images are available on the World Wide Web:http://www-star.st-and.ac.uk/^~ds10/spirals.html

Nonlinear two-stream interaction between a cold, relativistic electron beam and a collisional plasma-Astron experiment

International Nuclear Information System (INIS)

Newberger, B.S.; Thode, L.E.

1979-05-01

Experiments on the two-stream instability of a relativistic electron beam propagating through a neutral gas, carried out with the Lawrence Livermore Laboratory Astron beam, have been analyzed using a nonlinear saturation model for a cold beam. The behavior of the observed microwave emission due to the instability is in good agreement with that of the beam energy loss. Collisions on the plasma electrons weaken the nonlinear state of the instability but do not stabilize the mode. The beam essentially acts as if it were cold, a result substantiated by linear theory for waves propagating along the beam. In order to predict the effect of both beam momentum scatter and plasma electron collisions on the stability of the mode in future experiments a full two-dimensional linear theory must be developed

SOCS2 mediates the cross talk between androgen and growth hormone signaling in prostate cancer

DEFF Research Database (Denmark)

Iglesias Gato, Diego; Chuan, Yin Choy; Wikström, Pernilla

2014-01-01

) as mediator of the cross talk between androgens and GH signals in the prostate and its potential role as tumor suppressor in prostate cancer (PCa). We observed that SOCS2 protein levels assayed by immunohistochemistry are elevated in hormone therapy-naive localized prostatic adenocarcinoma in comparison...... of transcription 5 protein (STAT5) and androgen receptor-dependent transcription. Consequentially, SOCS2 inhibits GH activation of Janus kinase 2, Src and STAT5 as well as both cell invasion and cell proliferation in vitro. In vivo, SOCS2 limits proliferation and production of IGF-1 in the prostate in response......Anabolic signals such as androgens and the growth hormone/insulin-like growth factor 1 (GH/IGF-1) axis play an essential role in the normal development of the prostate but also in its malignant transformation. In this study, we investigated the role of suppressor of cytokine signaling 2 (SOCS2...

Growth hormone preferentially induces the rapid, transient expression of SOCS-3, a novel inhibitor of cytokine receptor signaling

DEFF Research Database (Denmark)

Adams, T E; Hansen, J A; Starr, R

1998-01-01

Four members (SOCS-1, SOCS-2, SOCS-3, and CIS) of a family of cytokine-inducible, negative regulators of cytokine receptor signaling have recently been identified. To address whether any of these genes are induced in response to growth hormone (GH), serum-starved 3T3-F442A fibroblasts were incuba...

SOC Strategies and Organizational Citizenship Behaviors toward the Benefits of Co-workers: A Multi-Source Study

Science.gov (United States)

Müller, Andreas; Weigl, Matthias

2017-01-01

Background: Individuals’ behavioral strategies like selection, optimization, and compensation (SOC) contribute to efficient use of available resources. In the work context, previous studies revealed positive associations between employees’ SOC use and favorable individual outcomes, like engagement and job performance. However, the social implications of self-directed behaviors like SOC that are favorable for the employee but may imply consequences for coworkers have not been investigated yet in an interpersonal work context. Objective: This study aimed to assess associations between employees’ use of SOC behaviors at work and their organizational citizenship behaviors (OCB) toward the benefits of co-workers rated by their peers at work. We further sought to identify age-specific associations between SOC use and OCB. Design and Method: A cross-sectional design combining multi-source data was applied in primary school teachers (age range: 23–58 years) who frequently teach in dyads. N = 114 dyads were finally included. Teachers reported on their SOC strategies at work. Their peer colleagues evaluated teachers’ OCB. Control variables were gender, workload, working hours, and perceived proximity of relationship between the dyads. Results: We observed a positive effect of loss-based selection behaviors on peer-rated OCB. Moreover, there was a significant two-way interaction effect between the use of compensation strategies and age on OCB, such that there was a positive association for older employees and a negative association for younger employees. There were no significant main and age-related interaction effects of elective selection, optimization, and of overall SOC strategies on OCB. Conclusion: Our study suggests that high use of loss-based selection and high use of compensation strategies in older employees is positively related with OCB as perceived by their colleagues. However, high use of compensation strategies in younger employees is perceived

Matching soil grid unit resolutions with polygon unit scales for DNDC modelling of regional SOC pool

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Zhang, H. D.; Yu, D. S.; Ni, Y. L.; Zhang, L. M.; Shi, X. Z.

2015-03-01

Matching soil grid unit resolution with polygon unit map scale is important to minimize uncertainty of regional soil organic carbon (SOC) pool simulation as their strong influences on the uncertainty. A series of soil grid units at varying cell sizes were derived from soil polygon units at the six map scales of 1:50 000 (C5), 1:200 000 (D2), 1:500 000 (P5), 1:1 000 000 (N1), 1:4 000 000 (N4) and 1:14 000 000 (N14), respectively, in the Tai lake region of China. Both format soil units were used for regional SOC pool simulation with DeNitrification-DeComposition (DNDC) process-based model, which runs span the time period 1982 to 2000 at the six map scales, respectively. Four indices, soil type number (STN) and area (AREA), average SOC density (ASOCD) and total SOC stocks (SOCS) of surface paddy soils simulated with the DNDC, were attributed from all these soil polygon and grid units, respectively. Subjecting to the four index values (IV) from the parent polygon units, the variation of an index value (VIV, %) from the grid units was used to assess its dataset accuracy and redundancy, which reflects uncertainty in the simulation of SOC. Optimal soil grid unit resolutions were generated and suggested for the DNDC simulation of regional SOC pool, matching with soil polygon units map scales, respectively. With the optimal raster resolution the soil grid units dataset can hold the same accuracy as its parent polygon units dataset without any redundancy, when VIV indices was assumed as criteria to the assessment. An quadratic curve regression model y = -8.0 × 10-6x2 + 0.228x + 0.211 (R2 = 0.9994, p < 0.05) was revealed, which describes the relationship between optimal soil grid unit resolution (y, km) and soil polygon unit map scale (1:x). The knowledge may serve for grid partitioning of regions focused on the investigation and simulation of SOC pool dynamics at certain map scale.

SOC Strategies and Organizational Citizenship Behaviors toward the Benefits of Co-workers: A Multi-Source Study

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Andreas Müller

2017-10-01

Full Text Available Background: Individuals’ behavioral strategies like selection, optimization, and compensation (SOC contribute to efficient use of available resources. In the work context, previous studies revealed positive associations between employees’ SOC use and favorable individual outcomes, like engagement and job performance. However, the social implications of self-directed behaviors like SOC that are favorable for the employee but may imply consequences for coworkers have not been investigated yet in an interpersonal work context.Objective: This study aimed to assess associations between employees’ use of SOC behaviors at work and their organizational citizenship behaviors (OCB toward the benefits of co-workers rated by their peers at work. We further sought to identify age-specific associations between SOC use and OCB.Design and Method: A cross-sectional design combining multi-source data was applied in primary school teachers (age range: 23–58 years who frequently teach in dyads. N = 114 dyads were finally included. Teachers reported on their SOC strategies at work. Their peer colleagues evaluated teachers’ OCB. Control variables were gender, workload, working hours, and perceived proximity of relationship between the dyads.Results: We observed a positive effect of loss-based selection behaviors on peer-rated OCB. Moreover, there was a significant two-way interaction effect between the use of compensation strategies and age on OCB, such that there was a positive association for older employees and a negative association for younger employees. There were no significant main and age-related interaction effects of elective selection, optimization, and of overall SOC strategies on OCB.Conclusion: Our study suggests that high use of loss-based selection and high use of compensation strategies in older employees is positively related with OCB as perceived by their colleagues. However, high use of compensation strategies in younger employees is

SOC Strategies and Organizational Citizenship Behaviors toward the Benefits of Co-workers: A Multi-Source Study.

Science.gov (United States)

Müller, Andreas; Weigl, Matthias

2017-01-01

Background: Individuals' behavioral strategies like selection, optimization, and compensation (SOC) contribute to efficient use of available resources. In the work context, previous studies revealed positive associations between employees' SOC use and favorable individual outcomes, like engagement and job performance. However, the social implications of self-directed behaviors like SOC that are favorable for the employee but may imply consequences for coworkers have not been investigated yet in an interpersonal work context. Objective: This study aimed to assess associations between employees' use of SOC behaviors at work and their organizational citizenship behaviors (OCB) toward the benefits of co-workers rated by their peers at work. We further sought to identify age-specific associations between SOC use and OCB. Design and Method: A cross-sectional design combining multi-source data was applied in primary school teachers (age range: 23-58 years) who frequently teach in dyads. N = 114 dyads were finally included. Teachers reported on their SOC strategies at work. Their peer colleagues evaluated teachers' OCB. Control variables were gender, workload, working hours, and perceived proximity of relationship between the dyads. Results: We observed a positive effect of loss-based selection behaviors on peer-rated OCB. Moreover, there was a significant two-way interaction effect between the use of compensation strategies and age on OCB, such that there was a positive association for older employees and a negative association for younger employees. There were no significant main and age-related interaction effects of elective selection, optimization, and of overall SOC strategies on OCB. Conclusion: Our study suggests that high use of loss-based selection and high use of compensation strategies in older employees is positively related with OCB as perceived by their colleagues. However, high use of compensation strategies in younger employees is perceived negatively

EpSoc: Social-Based Epidemic-Based Routing Protocol in Opportunistic Mobile Social Network

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Halikul Lenando

2018-01-01

Full Text Available In opportunistic networks, the nature of intermittent and disruptive connections degrades the efficiency of routing. Epidemic routing protocol is used as a benchmark for most of routing protocols in opportunistic mobile social networks (OMSNs due to its high message delivery and latency. However, Epidemic incurs high cost in terms of overhead and hop count. In this paper, we propose a hybrid routing protocol called EpSoc which utilizes the Epidemic routing forwarding strategy and exploits an important social feature, that is, degree centrality. Two techniques are used in EpSoc. Messages’ TTL is adjusted based on the degree centrality of nodes, and the message blocking mechanism is used to control replication. Simulation results show that EpSoc increases the delivery ratio and decreases the overhead ratio, the average latency, and the hop counts as compared to Epidemic and Bubble Rap.

Suppressor of Cytokine Signaling (SOCS 5 utilises distinct domains for regulation of JAK1 and interaction with the adaptor protein Shc-1.

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Edmond M Linossi

Full Text Available Suppressor of Cytokine Signaling (SOCS5 is thought to act as a tumour suppressor through negative regulation of JAK/STAT and epidermal growth factor (EGF signaling. However, the mechanism/s by which SOCS5 acts on these two distinct pathways is unclear. We show for the first time that SOCS5 can interact directly with JAK via a unique, conserved region in its N-terminus, which we have termed the JAK interaction region (JIR. Co-expression of SOCS5 was able to specifically reduce JAK1 and JAK2 (but not JAK3 or TYK2 autophosphorylation and this function required both the conserved JIR and additional sequences within the long SOCS5 N-terminal region. We further demonstrate that SOCS5 can directly inhibit JAK1 kinase activity, although its mechanism of action appears distinct from that of SOCS1 and SOCS3. In addition, we identify phosphoTyr317 in Shc-1 as a high-affinity substrate for the SOCS5-SH2 domain and suggest that SOCS5 may negatively regulate EGF and growth factor-driven Shc-1 signaling by binding to this site. These findings suggest that different domains in SOCS5 contribute to two distinct mechanisms for regulation of cytokine and growth factor signaling.

Dynamics and fate of SOC in tidal marshes along a salinity gradient (Scheldt estuary, Belgium)

Science.gov (United States)

Van de Broek, Marijn; Temmermann, Stijn; Merckx, Roel; Wang, Zhengang; Govers, Gerard

2016-04-01

Coastal ecosystems have been attributed the potential to store large amounts of organic carbon (OC), often referred to as blue carbon, of which a considerable amount is stored in tidal marsh soils. Large uncertainties still exist with respect to the amount and controlling factors of soil organic carbon (SOC) stored in these ecosystems. Moreover, most research has focused on SOC dynamics of saltmarshes, while brackish and freshwater marshes are often even more productive and thus receive even larger organic carbon inputs. Therefore, in this study the OC dynamics of tidal marsh soils along an estuarine gradient are studied in order to contribute to our knowledge of 1) the stocks, 2) the controlling factors and 3) the fate of SOC in tidal marshes with different environmental characteristics. This research thus contributes to a better understanding of the potential of coastal environments to store organic carbon under future climatic changes. Soil and vegetation samples are collected in tidal salt-, brackish- and freshwater marshes in the Scheldt estuary (Belgium - The Netherlands). At each tidal marsh, three replicate soil cores up to 1.5m depth in 0.03m increments are collected at locations with both a low and a high elevation. These cores are analyzed for OC, stable C and N isotopes, bulk density and texture. Incubation experiments of topsoil samples were conducted and both aboveground and belowground biomass were collected. The results show that SOC stocks (range: 13,5 - 35,4 kg OC m-2), standing biomass (range: 2000 - 7930 g DW m-2) and potential soil respiration of CO2 (range: 0,03 - 0,12 % per unit OC per day) decrease with increasing salinity. This shows that both the amount of OC from local macrophytes and the quality of the organic matter are important factors controlling the SOC stocks. In addition, based on the analysis of stable C and N isotopes, it appears that when a significant fraction of SOC is derived from local macrophytes, higher SOC stocks are

Looking a gift horse in the mouth: Evaluation of wide-field asteroid photometric surveys

Science.gov (United States)

Harris, Alan W.; Pravec, Petr; Warner, Brian D.

2012-09-01

It has recently become possible to do a photometric survey of many asteroids at once, rather than observing single asteroids one (or occasionally a couple) at a time. We evaluate two such surveys. Dermawan et al. (Dermawan et al. [2011]. Publ. Astron. Soc. Jpn. 63, S555-S576) observed one night on the Subaru 8.2 m telescope, and Masiero et al. (Masiero, J., Jedicke, R., Durech, J., Gwen, S., Denneau, L., Larsen, J. [2009]. Icarus 204, 145-171) observed six nights over 2 weeks with the 3.6 m CFHT. Dermawan claimed 83 rotation periods from 127 detected asteroids; Masiero et al. claimed 218 rotation periods from 828 detections. Both teams claim a number of super-fast rotators (P < 2.2 h) among main belt asteroids larger than 250 m diameter, some up to several km in diameter. This would imply that the spin rate distribution of main belt asteroids differs from like-sized NEAs, that there are larger super-fast rotators (monolithic asteroids) in the main belt than among NEAs. Here we evaluate these survey results, applying the same criteria for reliability of results that we apply to all results listed in our Lightcurve Database (Warner, B.D., Harris, A.W., Pravec, P. [2009a]. Icarus 202, 134-146). In doing so, we assigned reliability estimates judged sufficient for inclusion in statistical studies for only 27 out of 83 (33%) periods claimed by Dermawan, and only 87 out of 218 (40%) periods reported by Masiero et al.; none of the super-fast rotators larger than about 250 m diameter claimed by either survey received a reliability rating judged sufficient for analysis. We find no reliable basis for the claim of different rotation properties between main belt and near-Earth asteroids. Our analysis presents a cautionary message for future surveys.

Astronomical Perception of the Secondary School's Students in São Paulo's State School in Suzano City. (Spanish Title: Percepción Astronómica de Alumnos de la Enseñanza Media de la Red Estatal de San Pablo en la Ciudad de Suzano.) Percepção Astronômica de um Grupo de Alunos do Ensino Médio da Rede Estadual de São Paulo da Cidade de Suzano

Science.gov (United States)

França de Oliveira, Edilene; Voelzke, Marcos Rincon; Amaral, Luis Henrique

2007-12-01

Although Astronomy is one of the oldest Sciences in the world and many of its concepts are popular, it is possible to observe that a major part of the students do not know about them. This work aims to analyse the basic knowledge of the secondary school's students of a state school in the city of Suzano, related to the astronomical phenomena, which surround them. It was carried out a questionnaire of multiple choice to 34 students from the first grade, night classes, of the state school Batista Renzi. From the sample, 34 students, only 29.4% of them could understand the succession of the days; 20.6% could explain the seasons of the year and 20.6% had some idea about celestial objects nearer to the Earth. In turn, 67.6% correctly classified the Sun as a star; 55.9% related the Big Bang to the origin of Universe; only 20.6% identified the light-year as an unit of distance and 32.4% recognized a falling star as a meteor. The actual analysis was expanded to more 310 students of other classes, grades and periods of the same school. In this first stage, it can be noted the students' little discernment of the astronomical events and mainly the great confusion about the appropriate meaning of popular astronomical terms. Aunque la Astronomía es una de las ciencias más antiguas de la humanidad y muchos de los conceptos astronómicos son populares, se observa que una parcela significativa de los estudiantes se encuentra al margen de estas informaciones. El presente trabajo pretende analizar el nivel de conocimiento básico de los alumnos de la Enseñanza Media de la Red Estatal de la ciudad de Suzano con relación a los fenómenos astronómicos que los rodean. Con este objetivo fue elaborado un formulario constando de preguntas de selección múltipla, aplicado en el primer año nocturno de la Escuela Estatal Batista Renzi. En un universo de 34 alumnos se constató que solamente 29,4% comprendían la sucesión de los días; 20,6% explicaron correctamente las estaciones del

Longevity of contributions to SOC stocks from roots and aboveground plant litter below a Miscanthus plantation

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Robertson, Andrew; Smith, Pete; Davies, Christian; Bottoms, Emily; McNamara, Niall

2013-04-01

Miscanthus is a lignocellulosic crop that uses the Hatch-Slack (C4) photosynthetic pathway as opposed to most C3 vegetation native to the UK. Miscanthus can be grown for a number of practical end-uses but recently interest has increased in its viability as a bioenergy crop; both providing a renewable source of energy and helping to limit climate change by improving the carbon (C) budgets associated with energy generation. Recent studies have shown that Miscanthus plantations may increase stocks of soil organic carbon (SOC), however the longevity and origin of this 'new' SOC must be assessed. Consequently, we combined an input manipulation experiment with physio-chemical soil fractionation to quantify new SOC and CO2 emissions from Miscanthus roots, decomposing plant litter and soil individually. Further, fractionation of SOC from the top 30 cm gave insight into the longevity of that SOC. In January 2009 twenty-five 2 m2 plots were set up in a three-year old 11 hectare Miscanthus plantation in Lincolnshire, UK; with five replicates of five treatments. These treatments varied plant input to the soil by way of controlled exclusion techniques. Treatments excluded roots only ("No Roots"), surface litter only ("No Litter"), both roots and surface litter ("No Roots or Litter") or had double the litter amount added to the soil surface ("Double Litter"). A fifth treatment was a control with undisturbed roots and an average amount of litter added. Monthly measurements of CO2 emissions were taken at the soil surface from each treatment between March 2009 and March 2013, and soil C from the top 30 cm was monitored in all plots over the same period. Miscanthus-derived SOC was determined using the isotopic discrimination between C4 plant matter and C3 soil, and soil fractionation was then used to establish the longevity of that Miscanthus-derived SOC. Ongoing results for CO2 emissions indicate a strong seasonal variation; litter decomposition forms a large portion of the CO2

Suppressor of cytokine signaling 2 (SOCS2) deletion protects against multiple low dose streptozotocin-induced type 1 diabetes in adult male mice

DEFF Research Database (Denmark)

Alkharusi, Amira; Mirecki-Garrido, Mercedes; Ma, Zuheng

2016-01-01

Background: Diabetes type 1 is characterized by the failure of beta cells to produce insulin. Suppressor of cytokine signaling (SOCS) proteins are important regulators of the Janus kinase/signal transducer and activator of transcription (JAK-STAT) pathway. Previous studies have shown that GH can...... prevent the development of type I diabetes in mice and that SOCS2 deficiency mimics a state of increased GH sensitivity. Methodology: The elevated sensitivity of SOCS2-/- mice to GH and possibly to PRL was the rationale to analyze the effects of multiple low dose streptozotocin (MLDSTZ)-induced diabetes...... in SOCS2-/- mice. Results: We show that 6-month-old SOCS2-/- mice, but not 2-month-old mice, were less sensitive to MLDSTZ-induced diabetes, compared to controls. MLDSTZ treatment induced glucose intolerance in both SOCS2+/+ and SOCS2-/- mice, as shown by glucose tolerance tests, with SOCS2+/+ mice...

The mechanisms behind the formation of a strong Sense of Coherence (SOC): The role of migration and integration

NARCIS (Netherlands)

Slootjes, J.; Keuzenkamp, Saskia; Saharso, S.

2017-01-01

Considering how much we know about the impact of the Sense of Coherence (SOC) on different health-related outcomes, we know surprisingly little about how a strong SOC actually develops. In this study we examine the mechanisms behind the formation of a strong SOC and study the role of migration,

LCM-seq reveals the crucial role of LsSOC1 in heat-promoted bolting of lettuce (Lactuca sativa L.).

Science.gov (United States)

Chen, Zijing; Zhao, Wensheng; Ge, Danfeng; Han, Yingyan; Ning, Kang; Luo, Chen; Wang, Shenglin; Liu, Renyi; Zhang, Xiaolan; Wang, Qian

2018-05-17

Lettuce (Lactuca sativa L.) is one of the most economically important vegetables. The floral transition in lettuce is accelerated under high temperatures, which can significantly decrease yields. However, the molecular mechanism underlying the floral tranition in lettuce is poorly known. Using laser capture microdissection coupled with RNA sequencing, we isolated shoot apical meristem cells from the bolting-sensitive lettuce line S39 at four critical stages of development. Subsequently, we screened specifically for the flowering-related gene LsSOC1 during the floral transition through comparative transcriptomic analysis. Molecular biology, developmental biology, and biochemical tools were combined to investigate the biological function of LsSOC1 in lettuce. LsSOC1 knockdown by RNA interference resulted in a significant delay in the timing of bolting and insensitivity to high temperature, which indicated that LsSOC1 functions as an activator during heat-promoted bolting in lettuce. We determined that two heat-shock transcription factors, HsfA1e and HsfA4c, bound to the promoter of LsSOC1 to confirm that LsSOC1 played an important role in heat-promoted bolting. This study indicates that LsSOC1 plays a crucial role in the heat-promoted bolting process in lettuce. Further investigation of LsSOC1 may be useful for clarification of the bolting mechanism in lettuce. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

Influenza A virus inhibits type I IFN signaling via NF-kappaB-dependent induction of SOCS-3 expression.

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Eva-K Pauli

2008-11-01

Full Text Available The type I interferon (IFN system is a first line of defense against viral infections. Viruses have developed various mechanisms to counteract this response. So far, the interferon antagonistic activity of influenza A viruses was mainly observed on the level of IFNbeta gene induction via action of the viral non-structural protein 1 (NS1. Here we present data indicating that influenza A viruses not only suppress IFNbeta gene induction but also inhibit type I IFN signaling through a mechanism involving induction of the suppressor of cytokine signaling-3 (SOCS-3 protein. Our study was based on the observation that in cells that were infected with influenza A virus and subsequently stimulated with IFNalpha/beta, phosphorylation of the signal transducer and activator of transcription protein 1 (STAT1 was strongly reduced. This impaired STAT1 activation was not due to the action of viral proteins but rather appeared to be induced by accumulation of viral 5' triphosphate RNA in the cell. SOCS proteins are potent endogenous inhibitors of Janus kinase (JAK/STAT signaling. Closer examination revealed that SOCS-3 but not SOCS-1 mRNA levels increase in an RNA- and nuclear factor kappa B (NF-kappaB-dependent but type I IFN-independent manner early in the viral replication cycle. This direct viral induction of SOCS-3 mRNA and protein expression appears to be relevant for suppression of the antiviral response since in SOCS-3 deficient cells a sustained phosphorylation of STAT1 correlated with elevated expression of type I IFN-dependent genes. As a consequence, progeny virus titers were reduced in SOCS-3 deficient cells or in cells were SOCS-3 expression was knocked-down by siRNA. These data provide the first evidence that influenza A viruses suppress type I IFN signaling on the level of JAK/STAT activation. The inhibitory effect is at least in part due to the induction of SOCS-3 gene expression, which results in an impaired antiviral response.

Cardiac-Specific SOCS3 Deletion Prevents In Vivo Myocardial Ischemia Reperfusion Injury through Sustained Activation of Cardioprotective Signaling Molecules.

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Takanobu Nagata

Full Text Available Myocardial ischemia reperfusion injury (IRI adversely affects cardiac performance and the prognosis of patients with acute myocardial infarction. Although myocardial signal transducer and activator of transcription (STAT 3 is potently cardioprotective during IRI, the inhibitory mechanism responsible for its activation is largely unknown. The present study aimed to investigate the role of the myocardial suppressor of cytokine signaling (SOCS-3, an intrinsic negative feedback regulator of the Janus kinase (JAK-STAT signaling pathway, in the development of myocardial IRI. Myocardial IRI was induced in mice by ligating the left anterior descending coronary artery for 1 h, followed by different reperfusion times. One hour after reperfusion, the rapid expression of JAK-STAT-activating cytokines was observed. We precisely evaluated the phosphorylation of cardioprotective signaling molecules and the expression of SOCS3 during IRI and then induced myocardial IRI in wild-type and cardiac-specific SOCS3 knockout mice (SOCS3-CKO. The activation of STAT3, AKT, and ERK1/2 rapidly peaked and promptly decreased during IRI. This decrease correlated with the induction of SOCS3 expression up to 24 h after IRI in wild-type mice. The infarct size 24 h after reperfusion was significantly reduced in SOCS3-CKO compared with wild-type mice. In SOCS3-CKO mice, STAT3, AKT, and ERK1/2 phosphorylation was sustained, myocardial apoptosis was prevented, and the expression of anti-apoptotic Bcl-2 family member myeloid cell leukemia-1 (Mcl-1 was augmented. Cardiac-specific SOCS3 deletion led to the sustained activation of cardioprotective signaling molecules including and prevented myocardial apoptosis and injury during IRI. Our findings suggest that SOCS3 may represent a key factor that exacerbates the development of myocardial IRI.

Plant growth controls short-term changes in soil organic carbon (SOC) stocks of croplands - new insights from the CarboZALF experiment

Science.gov (United States)

Hoffmann, Mathias; Jurisch, Nicole; Garcia Alba, Joana; Albiac Borraz, Elisa; Schmidt, Marten; Verch, Gernot; Sommer, Michael; Augustin, Jürgen

2016-04-01

The long-term influence of crop rotations, climate conditions or soil type on soil organic carbon stock (SOC) patterns and gaseous C emissions of agricultural landscapes is widely recognized. However, the question of short-term seasonal changes in SOC within these areas remains unclear. A main reason for this is the detection problem of temporal and spatial variability in gaseous C exchange and thus, changes in SOC stocks (ΔSOC) in a high resolution. This study introduces dynamic C balances as a method to obtain seasonal changes in SOC stocks. Dynamic C balances were calculated by a combination of automatic chamber CO2 exchange measurements and empirical biomass models. Measurements were performed for three consecutive years at a colluvial depression (Colluvic Regosol) in the hummocky ground moraine landscape of NE Germany (CarboZALF experimental site). The investigated crop rotation was maize, winter fodder rye, maize, winter fodder rye, and sudangrass. The site is characterized by a gradient in ground water level (GWL) and related spatial heterogeneity in soil properties, such as SOC as well as soil nitrogen (Nt) stocks. Modelled dynamic C balances reveal that up to 79% of the standard deviation of estimated annual ΔSOC between single chambers emerged during the main period of crop growth (three months in summer). No significant changes in ΔSOC were detected outside the growing season. Instead, differences between chambers remain constant despite ΔSOC dynamics. Environmental variables (Nt stocks of Ap horizon and GWL), affecting plant-mediated C sequestration, explained up to 95% of temporal and spatial variability in CO2 exchange and ΔSOC. Thus, plant activities were the major catalyst for small scale differences in annual ΔSOC of croplands.

Research on SEU hardening of heterogeneous Dual-Core SoC

Science.gov (United States)

Huang, Kun; Hu, Keliu; Deng, Jun; Zhang, Tao

2017-08-01

The implementation of Single-Event Upsets (SEU) hardening has various schemes. However, some of them require a lot of human, material and financial resources. This paper proposes an easy scheme on SEU hardening for Heterogeneous Dual-core SoC (HD SoC) which contains three techniques. First, the automatic Triple Modular Redundancy (TMR) technique is adopted to harden the register heaps of the processor and the instruction-fetching module. Second, Hamming codes are used to harden the random access memory (RAM). Last, a software signature technique is applied to check the programs which are running on CPU. The scheme need not to consume additional resources, and has little influence on the performance of CPU. These technologies are very mature, easy to implement and needs low cost. According to the simulation result, the scheme can satisfy the basic demand of SEU-hardening.

Suppressor of cytokine signaling 4 (SOCS4 protects against severe cytokine storm and enhances viral clearance during influenza infection.

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Lukasz Kedzierski

2014-05-01

Full Text Available Suppressor of cytokine signaling (SOCS proteins are key regulators of innate and adaptive immunity. There is no described biological role for SOCS4, despite broad expression in the hematopoietic system. We demonstrate that mice lacking functional SOCS4 protein rapidly succumb to infection with a pathogenic H1N1 influenza virus (PR8 and are hypersusceptible to infection with the less virulent H3N2 (X31 strain. In SOCS4-deficient animals, this led to substantially greater weight loss, dysregulated pro-inflammatory cytokine and chemokine production in the lungs and delayed viral clearance. This was associated with impaired trafficking of influenza-specific CD8 T cells to the site of infection and linked to defects in T cell receptor activation. These results demonstrate that SOCS4 is a critical regulator of anti-viral immunity.

SOCS3 inhibits the pathological effects of IL-22 in non-melanoma skin tumor-derived keratinocytes.

Science.gov (United States)

Madonna, Stefania; Scarponi, Claudia; Morelli, Martina; Sestito, Rosanna; Scognamiglio, Pasqualina Liana; Marasco, Daniela; Albanesi, Cristina

2017-04-11

Basal cell carcinomas (BCC) and squamous-cell carcinomas (SCC) are common malignancies in humans, caused by neoplastic transformation of keratinocytes of the basal or suprabasal layers of epidermis, respectively. Tumor-infiltrating lymphocytes (TILs) are frequently found in BCC and SCC, and functionally promote epithelial carcinogenesis. TILs secreting IL-22, in particular, participate to BCC and SCC growth by inducing keratinocyte proliferation and migration, as well as the expression of inflammatory, anti-apoptotic and pro-angiogenic genes.In this study, we identified SOCS3 as a valid candidate to be manipulated for suppressing tumorigenic functions in BCC and SCC. We found that SOCS3 and SOCS1 expression was reduced in vivo, in tumor lesions of BCC and SCC, as compared to other skin inflammatory conditions such as psoriasis, despite the high number of IL-22-secreting TILs. Moreover, IL-22 was not able to induce in vitro the transcriptional expression of SOCS3 in BCC-or SCC-derived keratinocytes, contrarily to healthy cells. Aimed at rescuing SOCS3 activity in these tumor contexts, a SOCS3-derived peptide, named KIR-ESS, was synthesized, and its ability in suppressing IL-22-induced responses was evaluated in healthy and transformed keratinocytes. We found that KIR-ESS peptide efficiently suppressed the IL-22 molecular signaling in keratinocytes, by acting on STAT3 and Erk1/2 cascade, as well as on the expression of STAT3-dependent downstream genes. Interestingly, after treatment with peptide, both healthy and transformed keratinocytes could no longer aberrantly proliferate and migrate in response to IL-22. Finally, treatment of athymic nude mice bearing SCC xenografts with KIR-ESS peptide concomitantly reduced tumor growth and activated STAT3 levels. As a whole, these data provides the rationale for the use in BCC and SCC skin tumors of SOCS3 mimetics, being able to inhibit the deleterious effects of IL-22 in these contexts.

Authigenic carbonates in the sediments of Goa offshore basin, western continental margin of India

Digital Repository Service at National Institute of Oceanography (India)

Kocherla, M.

in all the studied locations. The methane con- centration varied from 0.45–5.25 nM (top) to 11.25 nM (middle) and 0.64–13.23 nM (bottom). The CaCO 3 content of the sediments ranged from 33.6% to 69.9% and TOC varied from 0.21% to 0.86%. The porosity.... G. and Almeida, F., Detection of gas charged sediments and gas hydrate horizons in high resolution seismic profiles from the western con- tinental margin of India. Spec. Publ. Geol. Soc. Lond., 1998, 137, 239–253. 15. Satyavani, N., Thankur, N. K...

Transport-distance specific SOC distribution: Does it skew erosion induced C fluxes?

DEFF Research Database (Denmark)

Hu, Yaxian; Berbe, Asmerat Asefaw; Fogel, Marilyn L.

2016-01-01

Abstract The net effect of soil erosion by water, as a sink or source of atmospheric carbon dioxide (CO2), is determined by the spatial (re-)distribution and stability of eroded soil organic carbon (SOC), and the dynamic replacement of eroded C by the production of new photosynthate. The depositi......Abstract The net effect of soil erosion by water, as a sink or source of atmospheric carbon dioxide (CO2), is determined by the spatial (re-)distribution and stability of eroded soil organic carbon (SOC), and the dynamic replacement of eroded C by the production of new photosynthate...... the actual movement of eroded soil fractions along hillslopes, let alone the re-distribution pattern of SOC fractions. Eroding sandy soils and sediment were sampled after a series of rainfall events along a slope on a freshly seeded cropland in Jutland, Denmark. All the soil samples were fractionated...... into five settling classes using a settling tube apparatus. The spatial distribution of soil settling classes shows a coarsening effect immediately below the eroding slope, followed by a fining trend at the slope tail. These findings support the validity of the conceptual model proposed by Starr et al...

The properties of radio ellipticals

International Nuclear Information System (INIS)

Sparks, W.B.; Disney, M.J.; Rodgers, A.W.

1984-01-01

Optical and additional radio data are presented for the bright galaxies of the Disney and Wall survey (1977 Mon. Not. R. Astron. Soc. 179, 235). These data form the basis of a statistical comparison of the properties of radio elliptical galaxies to radio-quiet ellipticals. The correlations may be explained by the depth of the gravitational potential well in which the galaxy resides governing the circumstances under which an elliptical galaxy rids itself of internally produced gas. (author)

Design of a Bidirectional Energy Storage System for a Vanadium Redox Flow Battery in a Microgrid with SOC Estimation

Directory of Open Access Journals (Sweden)

Qingwu Gong

2017-03-01

Full Text Available This paper used a Vanadium Redox flow Battery (VRB as the storage battery and designed a two-stage topology of a VRB energy storage system in which a phase-shifted full bridge dc-dc converter and three-phase inverter were used, considering the low terminal voltage of the VRB. Following this, a model of the VRB was simplified, according to the operational characteristics of the VRB in this designed topology of a VRB energy storage system (ESS. By using the simplified equivalent model of the VRB, the control parameters of the ESS were designed. For effectively estimating the state of charge (SOC of the VRB, a traditional method for providing the SOC estimation was simplified, and a simple and effective SOC estimation method was proposed in this paper. Finally, to illustrate the proper design of the VRB ESS and the proposed SOC estimation method, a corresponding simulation was designed by Simulink. The test results have demonstrated that this proposed SOC estimation method is feasible and effective for indicating the SOC of a VRB and the proper design of this VRB ESS is very reasonable for VRB applications.

High organic inputs explain shallow and deep SOC storage in a long-term agroforestry system - combining experimental and modeling approaches

Science.gov (United States)

Cardinael, Rémi; Guenet, Bertrand; Chevallier, Tiphaine; Dupraz, Christian; Cozzi, Thomas; Chenu, Claire

2018-01-01

Agroforestry is an increasingly popular farming system enabling agricultural diversification and providing several ecosystem services. In agroforestry systems, soil organic carbon (SOC) stocks are generally increased, but it is difficult to disentangle the different factors responsible for this storage. Organic carbon (OC) inputs to the soil may be larger, but SOC decomposition rates may be modified owing to microclimate, physical protection, or priming effect from roots, especially at depth. We used an 18-year-old silvoarable system associating hybrid walnut trees (Juglans regia × nigra) and durum wheat (Triticum turgidum L. subsp. durum) and an adjacent agricultural control plot to quantify all OC inputs to the soil - leaf litter, tree fine root senescence, crop residues, and tree row herbaceous vegetation - and measured SOC stocks down to 2 m of depth at varying distances from the trees. We then proposed a model that simulates SOC dynamics in agroforestry accounting for both the whole soil profile and the lateral spatial heterogeneity. The model was calibrated to the control plot only. Measured OC inputs to soil were increased by about 40 % (+ 1.11 t C ha-1 yr-1) down to 2 m of depth in the agroforestry plot compared to the control, resulting in an additional SOC stock of 6.3 t C ha-1 down to 1 m of depth. However, most of the SOC storage occurred in the first 30 cm of soil and in the tree rows. The model was strongly validated, properly describing the measured SOC stocks and distribution with depth in agroforestry tree rows and alleys. It showed that the increased inputs of fresh biomass to soil explained the observed additional SOC storage in the agroforestry plot. Moreover, only a priming effect variant of the model was able to capture the depth distribution of SOC stocks, suggesting the priming effect as a possible mechanism driving deep SOC dynamics. This result questions the potential of soils to store large amounts of carbon, especially at depth. Deep

3D integration for NoC-based SoC architectures

CERN Document Server

Sheibanyrad, Abbas; Pétrot, Frédéric

2011-01-01

3D-Integration for NoC-based SoC Architectures gathers the recent advances in the whole domain by renowned experts in the field to build a comprehensive and consistent book around the hot topics of three-dimensional architectures and micro-architectures.

Kepler: A Search for Terrestrial Planets - SOC 9.3 DR25 Pipeline Parameter Configuration Reports

Science.gov (United States)

Campbell, Jennifer R.

2017-01-01

This document describes the manner in which the pipeline and algorithm parameters for the Kepler Science Operations Center (SOC) science data processing pipeline were managed. This document is intended for scientists and software developers who wish to better understand the software design for the final Kepler codebase (SOC 9.3) and the effect of the software parameters on the Data Release (DR) 25 archival products.

Computational model of 18650 lithium-ion battery with coupled strain rate and SOC dependencies

International Nuclear Information System (INIS)

Xu, Jun; Liu, Binghe; Wang, Xinyi; Hu, Dayong

2016-01-01

Highlights: • An anisotropic model to describe mechanical behaviors of LIB is established. • SOC dependency is included in the mechanical model of the jellyroll. • Dynamic effect is considered in the model for LIB. - Abstract: Highly nonlinear structures and constituent materials and hazardous experiment situations have resulted in a pressing need for a numerical mechanical model for lithium-ion battery (LIB). However, such a model is still not well established. In this paper, an anisotropic homogeneous model describing the jellyroll and the battery shell is established and validated through compression, indentation, and bending tests at quasi-static loadings. In this model, state-of-charge (SOC) dependency of the LIB is further included through an analogy with the strain-rate effect. Moreover, with consideration of the inertia and strain-rate effects, the anisotropic homogeneous model is extended into the dynamic regime and proven capable of predicting the dynamic response of the LIB using the drop-weight test. The established model may help to predict extreme cases with high SOCs and crashing speeds with an over 135% improved accuracy compared to traditional models. The established coupled strain rate and SOC dependencies of the numerical mechanical model for the LIB aims to provide a solid step toward unraveling and quantifying the complicated problems for research on LIB mechanical integrity.

Online cell SOC estimation of Li-ion battery packs using a dual time-scale Kalman filtering for EV applications

International Nuclear Information System (INIS)

Dai, Haifeng; Wei, Xuezhe; Sun, Zechang; Wang, Jiayuan; Gu, Weijun

2012-01-01

Highlights: ► We use an equivalent circuit model to describe the characteristics of battery. ► A dual time-scale estimator is used to calculate pack average SOC and cell SOC. ► The estimator is based on the dynamic descriptions and extended Kalman filter. ► Three different test cases are designed to validate the proposed method. ► Test results indicate a good performance of the method for EV applications. -- Abstract: For the vehicular operation, due to the voltage and power/energy requirements, the battery systems are usually composed of up to hundreds of cells connected in series or parallel. To accommodate the operation conditions, the battery management system (BMS) should estimate State of Charge (SOC) to facilitate safe and efficient utilization of the battery. The performance difference among the cells makes a pure pack SOC estimation hardly provide sufficient information, which at last affects the computation of available energy and power and the safety of the battery system. So for a reliable and accurate management, the BMS should “know” the SOC of each individual cell. Several possible solutions on this issue have been reported in the recent years. This paper studies a method to determine online all individual cell SOCs of a series-connected battery pack. This method, with an equivalent circuit based “averaged cell” model, estimates the battery pack’s average SOC first, and then incorporates the performance divergences between the “averaged cell” and each individual cell to generate the SOC estimations for all cells. This method is developed based on extended Kalman filter (EKF), and to reduce the computation cost, a dual time-scale implementation is designed. The method is validated using results obtained from the measurements of a Li-ion battery pack under three different tests, and analysis indicates the good performance of the algorithm.

A microprocessor from AVR to embedded SoC

International Nuclear Information System (INIS)

Jeong, Geum Seoh

2005-01-01

This book was divided into two parts. The first part consists of ten chapter, which are basic knowledge, code vision AVR compiler, analysis on code vision, introduction and characteristic of AVR, I/O ports, interrupt and timer/counter, LCD, serial communication, analog comparator and stepping Motor and digital control of DC Motor. In the second part, it introduces Embedded Soc including application field, its characteristic, general description, functional description, designs with Quartus II.

A Cryptographic SoC for Robust Protection of Secret Keys in IPTV DRM Systems

Science.gov (United States)

Lee, Sanghan; Yang, Hae-Yong; Yeom, Yongjin; Park, Jongsik

The security level of an internet protocol television (IPTV) digital right management (DRM) system ultimately relies on protection of secret keys. Well known devices for the key protection include smartcards and battery backup SRAMs (BB-SRAMs); however, these devices could be vulnerable to various physical attacks. In this paper, we propose a secure and cost-effective design of a cryptographic system on chip (SoC) that integrates the BB-SRAM with a cell-based design technique. The proposed SoC provides robust safeguard against the physical attacks, and satisfies high-speed and low-price requirements of IPTV set-top boxes. Our implementation results show that the maximum encryption rate of the SoC is 633Mb/s. In order to verify the data retention capabilities, we made a prototype chip using 0.18µm standard cell technology. The experimental results show that the integrated BB-SRAM can reliably retain data with a 1.4µA leakage current.

Gaining Insights on the H2–Sorbent Interactions: Robust soc-MOF Platform as a Case Study

KAUST Repository

Cairns, Amy

2016-09-18

We report on the synthesis and gas adsorption properties (i.e., Ar and H2) of four robust 3-periodic metal–organic frameworks (MOFs) having the targeted soc topology. These cationic MOFs are isostructural to the parent indium-based MOF, In-soc-MOF-1a (for NO3–), previously reported by us, and likewise are constructed from the assembly of rigid μ3-oxygen-centered trinuclear metal carboxylate clusters, [M3O(O2C−)6], where M = In3+ or Fe3+. Each inorganic trinuclear molecular building block (MBB), generated in situ, is bridged by six 3,3′,5,5′-azobenzenetetracarboxylate (ABTC4–) ligands to give the extended (4,6)-connected MOF, soc-MOF. In our previous work, we confirmed that the parent soc-MOF, i.e., In-soc-MOF-1a, possesses unique structural characteristics (e.g., vacant In binding sites and narrow pores with higher localized charge density), which led to exceptional hydrogen (H2) storage capabilities. Therefore, charged MOFs with soc topology can be viewed collectively as an ideal prototypical platform to examine the impact of specific structural parameters on H2–MOF interactions via systematic gas adsorption studies. We infer that enhanced binding of molecular H2 is primarily governed by the presence and type of vacant metal centers (i.e., Fe was shown to exhibit stronger H2–MOF interactions at low H2 loading compared to the In analogues). These findings are evident from the associated isosteric heat of adsorption (Qst) at low loadings and inelastic neutron scattering (INS) experiments of the rotational transitions of sorbed H2, as well as, temperature-programmed desorption (TPD) studies (for a select compound). The importance of localized charge density is also highlighted, where the extra-framework nitrate anions in the Fe-soc-MOF-1a (for NO3–) facilitate enhanced binding affinities as compared to the chloride analogue.

Prediction of SOC content by Vis-NIR spectroscopy at European scale using a modified local PLS algorithm

Science.gov (United States)

Nocita, M.; Stevens, A.; Toth, G.; van Wesemael, B.; Montanarella, L.

2012-12-01

In the context of global environmental change, the estimation of carbon fluxes between soils and the atmosphere has been the object of a growing number of studies. This has been motivated notably by the possibility to sequester CO2 into soils by increasing the soil organic carbon (SOC) stocks and by the role of SOC in maintaining soil quality. Spatial variability of SOC masks its slow accumulation or depletion, and the sampling density required to detect a change in SOC content is often very high and thus very expensive and labour intensive. Visible near infrared diffuse reflectance spectroscopy (Vis-NIR DRS) has been shown to be a fast, cheap and efficient tool for the prediction of SOC at fine scales. However, when applied to regional or country scales, Vis-NIR DRS did not provide sufficient accuracy as an alternative to standard laboratory soil analysis for SOC monitoring. Under the framework of Land Use/Cover Area Frame Statistical Survey (LUCAS) project of the European Commission's Joint Research Centre (JRC), about 20,000 samples were collected all over European Union. Soil samples were analyzed for several physical and chemical parameters, and scanned with a Vis-NIR spectrometer in the same laboratory. The scope of our research was to predict SOC content at European scale using LUCAS spectral library. We implemented a modified local partial least square regression (l-PLS) including, in addition to spectral distance, other potentially useful covariates (geography, texture, etc.) to select for each unknown sample a group of predicting neighbours. The dataset was split in mineral soils under cropland, mineral soils under grassland, mineral soils under woodland, and organic soils due to the extremely diverse spectral response of the four classes. Four every class training (70%) and test (30%) sets were created to calibrate and validate the SOC prediction models. The results showed very good prediction ability for mineral soils under cropland and mineral soils

UD-DKF-based Parameters on-line Identification Method and AEKF-Based SOC Estimation Strategy of Lithium-ion Battery

Directory of Open Access Journals (Sweden)

Xuanju Dang

2014-09-01

Full Text Available State of charge (SOC is a significant parameter for the Battery Management System (BMS. The accurate estimation of the SOC can not only guarantee the SOC remaining within a reasonable scope of work, but also prevent the battery from being over or deeply-charged to extend the lifespan of battery. In this paper, the third-order RC equivalent circuit model is adopted to describe cell characteristics and the dual Kalman filter (DKF is used online to identify model parameters for battery. In order to avoid the impacts of rounding error calculation leading to the estimation error matrix loss of non-negative qualitative which result in the filtering divergence phenomenon, the UD decomposition method is applied for filtering time and state updates simultaneously to enhance the stability of the algorithm, reduce the computational complexity and improve the high recognition accuracy. Based on the obtained model parameters, Adaptive Extended Kalman Filter (AEKF is introduced to online estimate the SOC of battery. The simulation and experimental results demonstrate that the established third-order RC equivalent circuit model is effective, and the SOC estimation has a higher precision.

Role of Ubiquitylation in Controlling Suppressor of Cytokine Signalling 3 (SOCS3 Function and Expression

Directory of Open Access Journals (Sweden)

Jamie J. L. Williams

2014-05-01

Full Text Available The realisation that unregulated activation of the Janus kinase–signal transducer and activator of transcription (JAK–STAT pathway is a key driver of a wide range of diseases has identified its components as targets for therapeutic intervention by small molecule inhibitors and biologicals. In this review, we discuss JAK-STAT signalling pathway inhibition by the inducible inhibitor “suppressor of cytokine signaling 3 (SOCS3, its role in diseases such as myeloproliferative disorders, and its function as part of a multi-subunit E3 ubiquitin ligase complex. In addition, we highlight potential applications of these insights into SOCS3-based therapeutic strategies for management of conditions such as vascular re-stenosis associated with acute vascular injury, where there is strong evidence that multiple processes involved in disease progression could be attenuated by localized potentiation of SOCS3 expression levels.

Space Operations Center system analysis. Volume 3, book 2: SOC system definition report, revision A

Science.gov (United States)

1982-01-01

The Space Operations Center (SOC) orbital space station program operations are described. A work breakdown structure for the general purpose support equipment, construction and transportation support, and resupply and logistics support systems is given. The basis for the design of each element is presented, and a mass estimate for each element supplied. The SOC build-up operation, construction, flight support, and satellite servicing operations are described. Detailed programmatics and cost analysis are presented.

A Framework for Hardware-Accelerated Services Using Partially Reconfigurable SoCs

Directory of Open Access Journals (Sweden)

MACHIDON, O. M.

2016-05-01

Full Text Available The current trend towards ?Everything as a Service? fosters a new approach on reconfigurable hardware resources. This innovative, service-oriented approach has the potential of bringing a series of benefits for both reconfigurable and distributed computing fields by favoring a hardware-based acceleration of web services and increasing service performance. This paper proposes a framework for accelerating web services by offloading the compute-intensive tasks to reconfigurable System-on-Chip (SoC devices, as integrated IP (Intellectual Property cores. The framework provides a scalable, dynamic management of the tasks and hardware processing cores, based on dynamic partial reconfiguration of the SoC. We have enhanced security of the entire system by making use of the built-in detection features of the hardware device and also by implementing active counter-measures that protect the sensitive data.

Cache Performance Optimization for SoC Vedio Applications

OpenAIRE

Lei Li; Wei Zhang; HuiYao An; Xing Zhang; HuaiQi Zhu

2014-01-01

Chip Multiprocessors (CMPs) are adopted by industry to deal with the speed limit of the single-processor. But memory access has become the bottleneck of the performance, especially in multimedia applications. In this paper, a set of management policies is proposed to improve the cache performance for a SoC platform of video application. By analyzing the behavior of Vedio Engine, the memory-friendly writeback and efficient prefetch policies are adopted. The experiment platform is simulated by ...

Design of a Programmable Passive SoC for Biomedical Applications Using RFID ISO 15693/NFC5 Interface

Directory of Open Access Journals (Sweden)

Mayukh Bhattacharyya

2018-01-01

Full Text Available Low power, low cost inductively powered passive biotelemetry system involving fully customized RFID/NFC interface base SoC has gained popularity in the last decades. However, most of the SoCs developed are application specific and lacks either on-chip computational or sensor readout capability. In this paper, we present design details of a programmable passive SoC in compliance with ISO 15693/NFC5 standard for biomedical applications. The integrated system consists of a 32-bit microcontroller, a sensor readout circuit, a 12-bit SAR type ADC, 16 kB RAM, 16 kB ROM and other digital peripherals. The design is implemented in a 0.18 μ m CMOS technology and used a die area of 1.52 mm × 3.24 mm. The simulated maximum power consumption of the analog block is 592 μ W. The number of external components required by the SoC is limited to an external memory device, sensors, antenna and some passive components. The external memory device contains the application specific firmware. Based on the application, the firmware can be modified accordingly. The SoC design is suitable for medical implants to measure physiological parameters like temperature, pressure or ECG. As an application example, the authors have proposed a bioimplant to measure arterial blood pressure for patients suffering from Peripheral Artery Disease (PAD.

A Flexible ADC Approach for Mixed-signal SoC Platforms

NARCIS (Netherlands)

Zanikopoulos, A.; Harpe, P.J.A.; Hegt, J.A.; Roermund, van A.H.M.

2005-01-01

Time-to-market pressure and increased design complexity created what is called a "design gap" [1] in the design of systems-on-chip (SoC). As a solution to that problem the Platform-Based Design (PBD), based on the design-reuse methodology, has been proposed [2], and successfully applied to digital

Structural basis for c-KIT inhibition by the suppressor of cytokine signaling 6 (SOCS6) ubiquitin ligase

DEFF Research Database (Denmark)

Zadjali, Fahad; Pike, Ashley C W; Vesterlund, Mattias

2011-01-01

to substrate residue position pY+6 and envelopes the c-KIT phosphopeptide with a large BG loop insertion that contributes significantly to substrate interaction. We demonstrate that SOCS6 has ubiquitin ligase activity toward c-KIT and regulates c-KIT protein turnover in cells. Our data support a role of SOCS6...

ORCHIDEE-SOM: modeling soil organic carbon (SOC) and dissolved organic carbon (DOC) dynamics along vertical soil profiles in Europe

Science.gov (United States)

Camino-Serrano, Marta; Guenet, Bertrand; Luyssaert, Sebastiaan; Ciais, Philippe; Bastrikov, Vladislav; De Vos, Bruno; Gielen, Bert; Gleixner, Gerd; Jornet-Puig, Albert; Kaiser, Klaus; Kothawala, Dolly; Lauerwald, Ronny; Peñuelas, Josep; Schrumpf, Marion; Vicca, Sara; Vuichard, Nicolas; Walmsley, David; Janssens, Ivan A.

2018-03-01

Current land surface models (LSMs) typically represent soils in a very simplistic way, assuming soil organic carbon (SOC) as a bulk, and thus impeding a correct representation of deep soil carbon dynamics. Moreover, LSMs generally neglect the production and export of dissolved organic carbon (DOC) from soils to rivers, leading to overestimations of the potential carbon sequestration on land. This common oversimplified processing of SOC in LSMs is partly responsible for the large uncertainty in the predictions of the soil carbon response to climate change. In this study, we present a new soil carbon module called ORCHIDEE-SOM, embedded within the land surface model ORCHIDEE, which is able to reproduce the DOC and SOC dynamics in a vertically discretized soil to 2 m. The model includes processes of biological production and consumption of SOC and DOC, DOC adsorption on and desorption from soil minerals, diffusion of SOC and DOC, and DOC transport with water through and out of the soils to rivers. We evaluated ORCHIDEE-SOM against observations of DOC concentrations and SOC stocks from four European sites with different vegetation covers: a coniferous forest, a deciduous forest, a grassland, and a cropland. The model was able to reproduce the SOC stocks along their vertical profiles at the four sites and the DOC concentrations within the range of measurements, with the exception of the DOC concentrations in the upper soil horizon at the coniferous forest. However, the model was not able to fully capture the temporal dynamics of DOC concentrations. Further model improvements should focus on a plant- and depth-dependent parameterization of the new input model parameters, such as the turnover times of DOC and the microbial carbon use efficiency. We suggest that this new soil module, when parameterized for global simulations, will improve the representation of the global carbon cycle in LSMs, thus helping to constrain the predictions of the future SOC response to global

[Characteristics of Soil Respiration along Eroded Sloping Land with Different SOC Background on the Hilly Loess Plateau].

Science.gov (United States)

Chen, Gai; Xu, Ming-xiang; Zhang, Ya-feng; Wang, Chao-hua; Fan, Hui-min; Wang, Shan-shan

2015-09-01

This study aimed to characterize soil respiration along eroded sloping land at erosion and deposition area under different soil organic carbon(SOC) levels, and linked the relationship between soil respiration and soil temperature, soil moisture, SOC and slope position. Experiments were carried out in the plots of S type slopes include five different soil organic carbon levels in the Loess Hilly Region. The S type slopes were divided into control area at the top of the slope, erosion area at the middle of the slope and deposition area at the toe of the slope. We found that soil temperature had a greater impact on soil respiration in the deposition area, whereas soil moisture had a greater impact on soil respiration in the erosion area compared among control area, erosion area and deposition area. In addition, SOC was the most important factor affecting soil respiration, which can explain soil respiration variation 54. 72%, followed by soil moisture, slope position and soil temperature, which explain soil respiration variation 18. 86% , 16. 13% and 10. 29%, respectively. Soil respiration response to erosion showed obvious on-site and off-site effects along the eroded sloping land. Soil respiration in the erosion area was reduced by 21. 14% compared with control area, and soil respiration in the deposition area was increased by 21. 93% compared with control area. Erosion effect on source and sink of carbon emission was correlated with SOC content of the eroded sloping land. When SOC content was higher than 6. 82 g.kg-1, the slope. erosion tended to be a carbon sequestration process, and when SOC content was lower than 3.03 g.kg-1, the slope erosion tended to be a process of the carbon emission source. The model could reflect the relationship between soil respiration and independent variables of soil organic carbon content, soil temperature and moisture.

IL-6 modulates hepatocyte proliferation via induction of HGF/p21cip1: Regulation by SOCS3

International Nuclear Information System (INIS)

Sun Rui; Jaruga, Barbara; Kulkarni, Shailin; Sun Haoyu; Gao Bin

2005-01-01

The precise role of IL-6 in liver regeneration and hepatocyte proliferation is controversial and the role of SOCS3 in liver regeneration remains unknown. Here we show that in vitro treatment with IL-6 inhibited primary mouse hepatocyte proliferation. IL-6 induced p21 cip1 protein expression in primary mouse hepatocytes. Disruption of the p21 cip1 gene abolished the inhibitory effect of IL-6 on cell proliferation. Co-culture with nonparenchymal liver cells diminished IL-6 inhibition of hepatocyte proliferation, which was likely due to IL-6 stimulation of nonparenchymal cells to produce HGF. Finally, IL-6 induced higher levels of p21 cip1 protein expression and a slightly stronger inhibition of cell proliferation in SOCS3 +/- mouse hepatocytes compared to wild-type hepatocytes, while liver regeneration was enhanced and prolonged in SOCS3 +/- mice. Our findings suggest that IL-6 directly inhibits hepatocyte proliferation via a p21 cip1 -dependent mechanism and indirectly enhances hepatocyte proliferation via stimulating nonparenchymal cells to produce HGF. SOCS3 negatively regulates liver regeneration

Improved OCV Model of a Li-Ion NMC Battery for Online SOC Estimation Using the Extended Kalman Filter

Directory of Open Access Journals (Sweden)

Ines Baccouche

2017-05-01

Full Text Available Accurate modeling of the nonlinear relationship between the open circuit voltage (OCV and the state of charge (SOC is required for adaptive SOC estimation during the lithium-ion (Li-ion battery operation. Online SOC estimation should meet several constraints, such as the computational cost, the number of parameters, as well as the accuracy of the model. In this paper, these challenges are considered by proposing an improved simplified and accurate OCV model of a nickel manganese cobalt (NMC Li-ion battery, based on an empirical analytical characterization approach. In fact, composed of double exponential and simple quadratic functions containing only five parameters, the proposed model accurately follows the experimental curve with a minor fitting error of 1 mV. The model is also valid at a wide temperature range and takes into account the voltage hysteresis of the OCV. Using this model in SOC estimation by the extended Kalman filter (EKF contributes to minimizing the execution time and to reducing the SOC estimation error to only 3% compared to other existing models where the estimation error is about 5%. Experiments are also performed to prove that the proposed OCV model incorporated in the EKF estimator exhibits good reliability and precision under various loading profiles and temperatures.

Como os Alunos do Ensino Médio da Rede Estadual de São Paulo obtém Conhecimentos Astronômicos?

Science.gov (United States)

da Cunha, W. S.; Voelzke, M. R.; Amaral, L. H.

2005-08-01

Atualmente vivencia-se um mundo globalizado onde os computadores e a internet permitiram um acesso rápido e seguro a todo tipo de informação e conhecimento. O presente trabalho visa analisar a maneira pela qual alunos de segundo grau da rede estadual da cidade de São Paulo obtiveram, caso tenham, conhecimentos básicos de astronomia quanto aos fenômenos celestes que os rodeiam, tais como a sucessão dos dias e das estações do ano, além de questioná~los sobre fatos genéricos tais como: o que vem a ser o Sol, o Big Bang, o que ocasionou a extinção dos dinossauros. Para tanto foi elaborado um formulário constando de questões de múltipla escolha, o qual foi aplicado no primeiro colegial diurno da Escola Estadual Guilherme de Almeida. Num espaço amostral de 44 alunos constatou-se que 41% dos alunos adquiriram seus conhecimentos astronômicos na escola e 59% através da mídia em geral. Neste mesmo espaço amostral apenas 11% dos alunos usaram computadores na escola, 41% na residência, 5% no trabalho e 43% não utilizaram. O presente estudo revelou também que para 50% dos alunos o professor jamais utilizou um programa de computador a respeito de astronomia ou fez alguma apresentação sobre o tema. Embora em sua fase inicial este estudo revela claramente que a maioria dos alunos não obtém na escola seus conhecimentos astronômicos, estes provém de fontes não especificamente didático-pedagógicas tais como filmes e revistas populares que não raramente geram conhecimentos incompletos e em muitos casos inclusive falhos.

Analysis of Suppressor of Cytokine Signaling 2 Gene (SOCS2 Polymorphism in Different Dog Breeds

Directory of Open Access Journals (Sweden)

Martina Miluchová

2011-05-01

Full Text Available SOCS2 is a negative regulator of growth hormone signaling. The deletion of SOCS2 in mice results in a 30-50% increase in post-natal growth. The aim of the paper was to identify of suppressor of cytokine signaling 2 gene (SOCS2 polymorphism in different dog breeds. The material involved 77 dogs from 14 different breeds. Canine genomic DNA was isolated from saliva by modified method with using DNAzol® (Molecular Research Center and linear polyacrylamide (LPA carrier and from blood by using NucleospinBlood (Macherey-Nagel and used in order to estimate SOCS2 genotypes by PCR-RFLP method. The PCR products were digested with TaqI restriction enzyme. The T allele was distributed among large dog breeds (Czech pointer, Golden retriever, Rottweiler with an allele frequency ranging from 0.2857 to 1.00. In the population of Czech pointer we detected all genotypes. There were detected homozygote genotype GG with frequency 0.5476, heterozygote genotype GT with frequency 0.3333 and homozygote genotype TT with frequency 0.1191. Results point out that frequency of G allele was high and was represented 0.7143. Frequency of T allele was 0.2857. In Rottweiler was detected homozygote genotype TT. Genotypes GG and GT has not been observed. In Golden retriever we detected only heterozygote genotype GT.

Land use changing SOC pool: A field investigation from four catchments on the Loess Plateau in China

Science.gov (United States)

Guo, Shengli; Wang, Rui; Hu, Yaxian

2017-04-01

The Loess Plateau in China has long been known for severe erosion, a degraded ecosystem and heavy sediment delivery to the Yellow River. Apart from, the highly erodible loess soil and the hilly geomorphology, intensive cultivation has been caused such most destructive human activities. This made the Loess Plateau once the least fertile region in China with extreme poverty. To restore soil fertility and ecosystem sustainability, a national-level project was launched in 1990s to encourage land use changes via afforestation or conversion of cropland back to grassland or woodland. After nearly three decades of land use conversion, the SOC pool in the soil can be expected to have substantially changed. However, climate conditions, geomorphic types and soil properties were spatially distinctive across the Loess Plateau. Their individual as well interactive impacts on changes of soil carbon pool during land use conversions must thus be properly accounted for. In this study, four watersheds distributed over the Loess Plateau were investigated. The four watersheds mainly consisted of three geomorphic types: wide gully, loess ridge, and round knoll. On each geomorphic feature, three land use types prevailed: cropland, grassland and woodland. In total, 695 soil samples were taken from the top 20 cm of the four watersheds during 2010 and 2011. Our results show: 1) Degrees of erosion hugely differed among the four watersheds, with Catchment A (hilly) having three times more erosion modulus than the least eroded Catchment D (gully) (12000 vs. 1800 Mg per km2 per year). 2) The increasing SOC content from 4 mg g-1 at Catchment A to 8.1 mg g-1 at Catchment D agreed well with their decreasing erosion, suggesting that geomorphology induced erosion history was the predominant factor to set the general level of watershed-scale SOC reservoir. 3) Within each watershed, grassland and woodland consistently had at least 34% more SOC than cropland, demonstrating the influence of land use

High organic inputs explain shallow and deep SOC storage in a long-term agroforestry system – combining experimental and modeling approaches

Directory of Open Access Journals (Sweden)

R. Cardinael

2018-01-01

Full Text Available Agroforestry is an increasingly popular farming system enabling agricultural diversification and providing several ecosystem services. In agroforestry systems, soil organic carbon (SOC stocks are generally increased, but it is difficult to disentangle the different factors responsible for this storage. Organic carbon (OC inputs to the soil may be larger, but SOC decomposition rates may be modified owing to microclimate, physical protection, or priming effect from roots, especially at depth. We used an 18-year-old silvoarable system associating hybrid walnut trees (Juglans regia  ×  nigra and durum wheat (Triticum turgidum L. subsp. durum and an adjacent agricultural control plot to quantify all OC inputs to the soil – leaf litter, tree fine root senescence, crop residues, and tree row herbaceous vegetation – and measured SOC stocks down to 2 m of depth at varying distances from the trees. We then proposed a model that simulates SOC dynamics in agroforestry accounting for both the whole soil profile and the lateral spatial heterogeneity. The model was calibrated to the control plot only. Measured OC inputs to soil were increased by about 40 % (+ 1.11 t C ha−1 yr−1 down to 2 m of depth in the agroforestry plot compared to the control, resulting in an additional SOC stock of 6.3 t C ha−1 down to 1 m of depth. However, most of the SOC storage occurred in the first 30 cm of soil and in the tree rows. The model was strongly validated, properly describing the measured SOC stocks and distribution with depth in agroforestry tree rows and alleys. It showed that the increased inputs of fresh biomass to soil explained the observed additional SOC storage in the agroforestry plot. Moreover, only a priming effect variant of the model was able to capture the depth distribution of SOC stocks, suggesting the priming effect as a possible mechanism driving deep SOC dynamics. This result questions the potential of soils to

Daily Socs1 rhythms alter with aging differentially in peripheral clocks in male Wistar rats: therapeutic effects of melatonin.

Science.gov (United States)

Vinod, Ch; Jagota, Anita

2017-06-01

Suprachiasmatic nucleus (SCN) in synchronization with the peripheral clocks regulates the temporal oscillations leading to overt rhythms. Aging leads to attenuation of such circadian regulation, accompanied by increased inflammatory mediators prevalently the cytokines. Suppressors of cytokine signaling (SOCS) family of proteins such as SOCS 1, 3 and cytokine-inducible SH2-containing protein (CIS) negatively regulate the cytokine signaling pathway. The role of SOCS1 in aging and circadian system is obscure. We therefore studied the daily rhythms of rSocs1 mRNA expression at Zeitgeber time (ZT) -0, 6, 12 and 18 in peripheral clocks such as liver, kidney, intestine and heart of 3, 12 and 24 months (m) old male Wistar rats. Interestingly the peripheral clocks studied displayed a rhythmic rSocs1 gene expression in 3 months. In 12 months group, 12 h phase advance in liver and 12 h phase delay in kidney and heart was observed with abolition of rhythms in intestine. Aging (24 months group) resulted in a phase advance by 6 h in liver and heart with abolition of rhythms in intestine in 24 months group. Kidney was also significantly affected upon aging with significant decrease in the rSocs1 levels and abolition of rhythms. The decrease in melatonin levels with aging is associated with decreased immunity and increased oxidative stress. The exogenous administration of melatonin has been linked to play a role in re-synchronization of circadian rhythms, reducing oxidative stress and enhancing immune properties. We therefore had studied the effect of exogenous melatonin upon age induced changes in daily rSocs1 gene expression patterns. Melatonin treatment partially restored the rhythms and daily pulse (ratio of maximum:minimum levels) in liver and intestine in 12 months group. Melatonin administration resulted in a significant increase in mean 24 h rSocs1 expression in intestine and heart of 24 months group compared to that of 3 months. The melatonin administration

Parametric Dense Stereovision Implementation on a System-on Chip (SoC

Directory of Open Access Journals (Sweden)

Pablo Montejo

2012-02-01

Full Text Available This paper proposes a novel hardware implementation of a dense recovery of stereovision 3D measurements. Traditionally 3D stereo systems have imposed the maximum number of stereo correspondences, introducing a large restriction on artificial vision algorithms. The proposed system-on-chip (SoC provides great performance and efficiency, with a scalable architecture available for many different situations, addressing real time processing of stereo image flow. Using double buffering techniques properly combined with pipelined processing, the use of reconfigurable hardware achieves a parametrisable SoC which gives the designer the opportunity to decide its right dimension and features. The proposed architecture does not need any external memory because the processing is done as image flow arrives. Our SoC provides 3D data directly without the storage of whole stereo images. Our goal is to obtain high processing speed while maintaining the accuracy of 3D data using minimum resources. Configurable parameters may be controlled by later/parallel stages of the vision algorithm executed on an embedded processor. Considering hardware FPGA clock of 100 MHz, image flows up to 50 frames per second (fps of dense stereo maps of more than 30,000 depth points could be obtained considering 2 Mpix images, with a minimum initial latency. The implementation of computer vision algorithms on reconfigurable hardware, explicitly low level processing, opens up the prospect of its use in autonomous systems, and they can act as a coprocessor to reconstruct 3D images with high density information in real time.

Parametric dense stereovision implementation on a system-on chip (SoC).

Science.gov (United States)

Gardel, Alfredo; Montejo, Pablo; García, Jorge; Bravo, Ignacio; Lázaro, José L

2012-01-01

This paper proposes a novel hardware implementation of a dense recovery of stereovision 3D measurements. Traditionally 3D stereo systems have imposed the maximum number of stereo correspondences, introducing a large restriction on artificial vision algorithms. The proposed system-on-chip (SoC) provides great performance and efficiency, with a scalable architecture available for many different situations, addressing real time processing of stereo image flow. Using double buffering techniques properly combined with pipelined processing, the use of reconfigurable hardware achieves a parametrisable SoC which gives the designer the opportunity to decide its right dimension and features. The proposed architecture does not need any external memory because the processing is done as image flow arrives. Our SoC provides 3D data directly without the storage of whole stereo images. Our goal is to obtain high processing speed while maintaining the accuracy of 3D data using minimum resources. Configurable parameters may be controlled by later/parallel stages of the vision algorithm executed on an embedded processor. Considering hardware FPGA clock of 100 MHz, image flows up to 50 frames per second (fps) of dense stereo maps of more than 30,000 depth points could be obtained considering 2 Mpix images, with a minimum initial latency. The implementation of computer vision algorithms on reconfigurable hardware, explicitly low level processing, opens up the prospect of its use in autonomous systems, and they can act as a coprocessor to reconstruct 3D images with high density information in real time.

0.45 v and 18 μA/MHz MCU SOC with Advanced Adaptive Dynamic Voltage Control (ADVC

Directory of Open Access Journals (Sweden)

Uzi Zangi

2018-05-01

Full Text Available An ultra-low-power MicroController Unit System-on-Chip (MCU SOC is described with integrated DC to DC power management and Adaptive Dynamic Voltage Control (ADVC mechanism. The SOC, designed and fabricated in a 40 nm ULP standard CMOS technology, includes the complete Synopsys ARC EM5D core MCU, featuring a full set of DSP instructions and minimizing energy consumption at a wide range of frequencies: 312 K–80 MHz. A number of unique low voltage digital libraries, comprising of approximately 300 logic cells and sequential elements, were used for the MCU SOC design. On-die silicon sensors were utilized to continuously change the operating voltage to optimize power/performance for a given frequency and environmental conditions, and also to resolve yield and life time problems, while operating at low voltages. A First Fail (FFail mechanism, which can be digitally and linearly controlled with up to 8 bits, detects the failing SOC voltage at a given frequency. The core operates between 0.45–1.1 V volts with a direct battery connection for an input voltage of 1.6–3.6 V. Measurement results show that the peak energy efficiency is 18μW/MHz. A comparison to state-of-the-art commercial SOCs is presented, showing a 3–5× improved current/DMIPS (Dhrystone Million Instructions per second compared to the next best chip.

A new circuit for at-speed scan SoC testing

International Nuclear Information System (INIS)

Lin Wei; Shi Wenlong

2013-01-01

It is very important to detect transition-delay faults and stuck-at faults in system on chip (SoC) under 90 nm processing technology, and the transition-delay faults can only be detected by using an at-speed testing method. In this paper, an on-chip clock (OCC) controller with a bypass function based on an internal phase-locked loop is designed to test faults in SoC. Furthermore, a clock chain logic which can eliminate the metastable state is realized to generate an enable signal for the OCC controller, and then, the test pattern is generated by automatic test pattern generation (ATPG) tools. Next, the scan test pattern is simulated by using the Synopsys tool and the correctness of the design is verified. The result shows that the design of an at-speed scan test in this paper is highly efficient for detecting timing-related defects. Finally, the 89.29% transition-delay fault coverage and the 94.50% stuck-at fault coverage are achieved, and it is successfully applied to an integrated circuit design. (semiconductor integrated circuits)

Implementation of QoSS (Quality-of-Security Service) for NoC-Based SoC Protection

Science.gov (United States)

Sepúlveda, Johanna; Pires, Ricardo; Strum, Marius; Chau, Wang Jiang

Many of the current electronic systems embedded in a SoC (System-on-Chip) are used to capture, store, manipulate and access critical data, as well as to perform other key functions. In such a scenario, security is considered as an important issue. The Network-on-chip (NoC), as the foreseen communication structure of next-generation SoC devices, can be used to efficiently incorporate security. Our work proposes the implementation of QoSS (Quality of Security Service) to overcome present SoC vulnerabilities. QoSS is a novel concept for data protection that introduces security as a dimension of QoS. In this paper, we present the implementation of two security services (access control and authentication), that may be configured to assume one from several possible levels, the implementation of a technique to avoid denial-of-service (DoS) attacks, evaluate their effectiveness and estimate their impact on NoC performance.

Increasing SoC Dependability via Known Good Tile NoC Testing

NARCIS (Netherlands)

Kerkhoff, Hans G.; Kuiken, O.J.; Zhang, X.

2008-01-01

Advanced CMOS technology possibilities, power, communication and flexibility issues as well as the design gap are directing System-on-Chip (SoC) platforms towards Network-on-Chip (NoC) interconnected identical processing tiles (PT) such as the Montium processor [1]. It is broadly acknowledged that

Functional SOCS1 polymorphisms are associated with variation in obesity in whites

DEFF Research Database (Denmark)

Gylvin, T; Ek, J; Nolsøe, R.

2009-01-01

. A total of more than 8100 individuals were genotyped. RESULTS: Eight variations were identified in the 5' untranslated region (UTR) region. Two of these had allele frequencies below 1% and were not further examined. The six other variants were analysed in groups of T1D families (n = 1461 subjects) and T2D...... of both the rs33977706 and the rs243330 (-1656G > A) variants to obesity were found (p = 0.047 and p = 0.015) respectively. The rs33977706 affected both binding of a nuclear protein to and the transcriptional activity of the SOCS1 promoter, indicating a relationship between this polymorphism and gene...... regulation. CONCLUSIONS/INTERPRETATION: This study demonstrates that functional variations in the SOCS1 promoter may associate with alterations in BMI in the general white population....

Using SoC Online Correction Method Based on Parameter Identification to Optimize the Operation Range of NI-MH Battery for Electric Boat

Directory of Open Access Journals (Sweden)

Bumin Meng

2018-03-01

Full Text Available This paper discusses a design of a Battery Management System (BMS solution for extending the life of Nickel-Metal Hydride (NI-MH battery. Combined with application of electric boat, a State of Charge (SoC optimal operation range control method based on high precision energy metering and online SoC correction is proposed. Firstly, a power metering scheme is introduced to reduce the original energy measurement error. Secondly, by establishing a model based parameter identification method and combining with Extended Kalman Filter (EKF method, the estimation accuracy of SoC is guaranteed. Finally, SoC optimal operation range control method is presented to make battery running in the optimal range. After two years of operation, the battery managed by proposed method has much better status, compared to batteries that use AH integral method and fixed SoC operating range. Considering the SoC estimation of NI-MH battery is more difficult becausing special electrical characteristics, proposed method also would have a very good reference value for other types of battery management.

MOF Crystal Chemistry Paving the Way to Gas Storage Needs: Aluminum Based soc-MOF for CH4, O2 and CO2 Storage

KAUST Repository

Alezi, Dalal

2015-09-28

The molecular building block approach was employed effectively to construct a series of novel isoreticular, highly porous and stable, aluminum based Metal-Organic Frameworks with soc topology. From this platform, three compounds were experimentally isolated and fully characterized, namely, the parent Al-soc-MOF-1 and its naphthalene and anthracene analogues. Al-soc-MOF-1 exhibits outstanding gravimetric methane uptake (total and working capacity). It is shown experimentally, for the first time, that the Al-soc-MOF platform can address the challenging Department of Energy dual target of 0.5 g/g (gravimetric) and 264 cm3 (STP)/cm3 (volumetric) methane storage. Furthermore, Al-soc-MOF exhibited the highest total gravimetric and volumetric uptake for carbon dioxide and the utmost total and deliverable uptake for oxygen at relatively high pressures among all microporous MOFs. In order to correlate the MOF pore structure and functionality to the gas storage properties, to better understand the structure-properties relationship, we performed a molecular simulation study and evaluated the methane storage performance of Al-soc-MOF platform using diverse organic linkers. It was found that shortening the parent Al-soc-MOF-1 linker resulted in a noticeable enhancement in the working volumetric capacity at specific temperatures and pressures with amply conserved gravimetric uptake/working capacity. In contrast, further expansion of the organic linker (branches and/or core) led to isostructural Al-soc-MOFs with enhanced gravimetric uptake but noticeably lower volumetric capacity. The collective experimental and simulation studies indicated that the parent Al-soc-MOF-1 exhibits the best compromise between the volumetric and gravimetric total and working uptakes in a wide range of pressure and temperature conditions.

MOF Crystal Chemistry Paving the Way to Gas Storage Needs: Aluminum Based soc-MOF for CH4, O2 and CO2 Storage

KAUST Repository

Alezi, Dalal; Belmabkhout, Youssef; Suetin, Mikhail; Bhatt, Prashant; Weselinski, Lukasz Jan; Solovyeva, Vera; Adil, Karim; Spanopoulos, Ioannis; Trikalitis, Pantelis N.; Emwas, Abdul-Hamid M.; Eddaoudi, Mohamed

2015-01-01

The molecular building block approach was employed effectively to construct a series of novel isoreticular, highly porous and stable, aluminum based Metal-Organic Frameworks with soc topology. From this platform, three compounds were experimentally isolated and fully characterized, namely, the parent Al-soc-MOF-1 and its naphthalene and anthracene analogues. Al-soc-MOF-1 exhibits outstanding gravimetric methane uptake (total and working capacity). It is shown experimentally, for the first time, that the Al-soc-MOF platform can address the challenging Department of Energy dual target of 0.5 g/g (gravimetric) and 264 cm3 (STP)/cm3 (volumetric) methane storage. Furthermore, Al-soc-MOF exhibited the highest total gravimetric and volumetric uptake for carbon dioxide and the utmost total and deliverable uptake for oxygen at relatively high pressures among all microporous MOFs. In order to correlate the MOF pore structure and functionality to the gas storage properties, to better understand the structure-properties relationship, we performed a molecular simulation study and evaluated the methane storage performance of Al-soc-MOF platform using diverse organic linkers. It was found that shortening the parent Al-soc-MOF-1 linker resulted in a noticeable enhancement in the working volumetric capacity at specific temperatures and pressures with amply conserved gravimetric uptake/working capacity. In contrast, further expansion of the organic linker (branches and/or core) led to isostructural Al-soc-MOFs with enhanced gravimetric uptake but noticeably lower volumetric capacity. The collective experimental and simulation studies indicated that the parent Al-soc-MOF-1 exhibits the best compromise between the volumetric and gravimetric total and working uptakes in a wide range of pressure and temperature conditions.

Matrine suppresses airway inflammation by downregulating SOCS3 expression via inhibition of NF-κB signaling in airway epithelial cells and asthmatic mice

Energy Technology Data Exchange (ETDEWEB)

Sun, Daqing [Department of Respiration, Xi’an Children’s Hospital, Xi’an 710003 (China); Wang, Jing [Department of Neonatology, Xi’an Children’s Hospital, Xi’an 710003 (China); Yang, Niandi [Outpatient Department, School of Aerospace Engineering, Air Force Engineering University, Xi’an 710038 (China); Ma, Haixin, E-mail: drhaixinma@163.com [Department of Quality Control, Xi’an Children’s Hospital, Xi’an 710003 (China)

2016-08-12

Matrine has been demonstrated to attenuate allergic airway inflammation. Elevated suppressor of cytokine signaling 3 (SOCS3) was correlated with the severity of asthma. The aim of this study was to investigate the effect of matrine on SOCS3 expression in airway inflammation. In this study, we found that matrine significantly inhibited OVA-induced AHR, inflammatory cell infiltration, goblet cell differentiation, and mucous production in a dose-dependent manner in mice. Matrine also abrogated the level of interleukin (IL)-4 and IL-13, but enhanced interferon (IFN)-γ expression, both in BALF and in lung homogenates. Furthermore, matrine impeded TNF-α-induced the expression of IL-6 and adhesion molecules in airway epithelial cells (BEAS-2B and MLE-12). Additionally, we found that matrine inhibited SOCS3 expression, both in asthmatic mice and TNF-α-stimulated epithelial cells via suppression of the NF-κB signaling pathway by using pcDNA3.1-SOCS3 plasmid, SOCS3 siRNA, or nuclear factor kappa-B (NF-κB) inhibitor PDTC. Conclusions: Matrine suppresses airway inflammation by downregulating SOCS3 expression via inhibition of NF-κB signaling in airway epithelial cells and asthmatic mice. - Highlights: • Matrine attenuates asthmatic symptoms and regulates Th1/Th2 balance in vivo. • Matrine suppresses inflammation responses in vitro. • Matrine decreases SOCS3 expression both in vivo and in vitro. • Matrine inhibits SOCS3 expression by suppressing NF-κB signaling.

Modeling of SOC-700 Hyperspectral Imagery with the CAMEO-SIM Code

Science.gov (United States)

2007-10-26

Yannick, 2001, “SOC-700 and HS-Analysis 2 User’s Manual”, Surface Optics, San Diego [2] Cohen, Michael F. and Wallace, John R., 1993, “ Radiosity ...and Realistic Image Synthesis”, Academic Press, San Francisco [3] Sillion, Francois X. and Puech, Claude, 1994, “ Radiosity and Global Illumination

Methylation of SOCS3 is inversely associated with metabolic syndrome in an epigenome-wide association study of obesity.

Science.gov (United States)

Ali, Omar; Cerjak, Diana; Kent, Jack W; James, Roland; Blangero, John; Carless, Melanie A; Zhang, Yi

2016-09-01

Epigenetic mechanisms, including DNA methylation, mediate the interaction between gene and environment and may play an important role in the obesity epidemic. We assessed the relationship between DNA methylation and obesity in peripheral blood mononuclear cells (PBMCs) at 485,000 CpG sites across the genome in family members (8-90 y of age) using a discovery cohort (192 individuals) and a validation cohort (1,052 individuals) of Northern European ancestry. After Bonferroni-correction (P α=0.05 = 1.31 × 10 -7 ) for genome-wide significance, we identified 3 loci, cg18181703 (SOCS3), cg04502490 (ZNF771), and cg02988947 (LIMD2), where methylation status was associated with body mass index percentile (BMI%), a clinical index for obesity in children, adolescents, and adults. These sites were also associated with multiple metabolic syndrome (MetS) traits, including central obesity, fat depots, insulin responsiveness, and plasma lipids. The SOCS3 methylation locus was also associated with the clinical definition of MetS. In the validation cohort, SOCS3 methylation status was found to be inversely associated with BMI% (P = 1.75 × 10 -6 ), waist to height ratio (P = 4.18 × 10 -7 ), triglycerides (P = 4.01 × 10 -4 ), and MetS (P = 4.01 × 10 -7 ), and positively correlated with HDL-c (P = 4.57 × 10 -8 ). Functional analysis in a sub cohort (333 individuals) demonstrated SOCS3 methylation and gene expression in PBMCs were inversely correlated (P = 2.93 × 10 -4 ) and expression of SOCS3 was positively correlated with status of MetS (P = 0.012). We conclude that epigenetic modulation of SOCS3, a gene involved in leptin and insulin signaling, may play an important role in obesity and MetS.

A configurable and low-power mixed signal SoC for portable ECG monitoring applications.

Science.gov (United States)

Kim, Hyejung; Kim, Sunyoung; Van Helleputte, Nick; Artes, Antonio; Konijnenburg, Mario; Huisken, Jos; Van Hoof, Chris; Yazicioglu, Refet Firat

2014-04-01

This paper describes a mixed-signal ECG System-on-Chip (SoC) that is capable of implementing configurable functionality with low-power consumption for portable ECG monitoring applications. A low-voltage and high performance analog front-end extracts 3-channel ECG signals and single channel electrode-tissue-impedance (ETI) measurement with high signal quality. This can be used to evaluate the quality of the ECG measurement and to filter motion artifacts. A custom digital signal processor consisting of 4-way SIMD processor provides the configurability and advanced functionality like motion artifact removal and R peak detection. A built-in 12-bit analog-to-digital converter (ADC) is capable of adaptive sampling achieving a compression ratio of up to 7, and loop buffer integration reduces the power consumption for on-chip memory access. The SoC is implemented in 0.18 μm CMOS process and consumes 32 μ W from a 1.2 V while heart beat detection application is running, and integrated in a wireless ECG monitoring system with Bluetooth protocol. Thanks to the ECG SoC, the overall system power consumption can be reduced significantly.

Pengaruh Variasi Jumlah Tembakan Nanosecond Pulsed Electric Fields (Nspefs Terhadap Ekspresi Gen Socs3 pada Sel Kanker Serviks Hela S3

Directory of Open Access Journals (Sweden)

Martina Kurnia Rohmah

2017-12-01

Abstract Nanosecond Pulsed Electric Fields (NsPEFs is bioelectric that was developed by electroporation technology. NsPEFs use high intensity in short time exposure (1 – 300 nanosecond. NsPEFs have biological effect and was developed in cancer therapy. In cervical cancer, viral protein of HPV depresses some tumor suppressors like Socs3 gene. This research aims to investigate the effect of short variation in Socs3 gene expression. HeLa S3 cells were cultured in α-MEM with FBS 10%. NsPEFs as much as 20 kV/cm and 80 nano seconds was exposure over HeLa S3 cell in 4 mm cuvette. Wave of NsPEFs was detected by high voltage probe in oscilloscope. NsPEFs was exposure at 0 (control, 5, 10, 20, 30, 40, 50, and 60 shots. Socs3 gene expression was analyzed using real time PCR and RT-PCR. Quantitative data was analyzed by Kolmogorov-Smirnov, Anova, and HSD Tuker (p<0.05. This research show that NsPEFs is significantly increase Socs3 gene expression (p=0.000. The optimal shot 20 and 30 shots increase Socs3 gene expression subsequently = 2.779 and = 3.105 times. This expression decrease in higher than 30 shots of NsPEFs exposure.   Keywords: NsPEFs, shot, expression, Socs3

An overview of online implementable SOC estimation methods for Lithium-ion batteries

DEFF Research Database (Denmark)

Jinhao, Meng; Ricco, Mattia; Guangzhao, Luo

2017-01-01

With the popularity of Electrical Vehicles (EVs), Lithium-ion battery industry is also developing rapidly. To ensure the battery safety usage and reduce the average lifecycle cost, accurate State Of Charge (SOC) tracking algorithms for real-time implementation are required in different applications...

Rock-Eval analysis of French forest soils: the influence of depth, soil and vegetation types on SOC thermal stability and bulk chemistry

Science.gov (United States)

Soucemarianadin, Laure; Cécillon, Lauric; Baudin, François; Cecchini, Sébastien; Chenu, Claire; Mériguet, Jacques; Nicolas, Manuel; Savignac, Florence; Barré, Pierre

2017-04-01

Soil organic matter (SOM) is the largest terrestrial carbon pool and SOM degradation has multiple consequences on key ecosystem properties like nutrients cycling, soil emissions of greenhouse gases or carbon sequestration potential. With the strong feedbacks between SOM and climate change, it becomes particularly urgent to develop reliable routine methodologies capable of indicating the turnover time of soil organic carbon (SOC) stocks. Thermal analyses have been used to characterize SOM and among them, Rock-Eval 6 (RE6) analysis of soil has shown promising results in the determination of in-situ SOC biogeochemical stability. This technique combines a phase of pyrolysis followed by a phase of oxidation to provide information on both the SOC bulk chemistry and thermal stability. We analyzed with RE6 a set of 495 soils samples from 102 permanent forest sites of the French national network for the long-term monitoring of forest ecosystems (''RENECOFOR'' network). Along with covering pedoclimatic variability at a national level, these samples include a range of 5 depths up to 1 meter (0-10 cm, 10-20 cm, 20-40 cm, 40-80 cm and 80-100 cm). Using RE6 parameters that were previously shown to be correlated to short-term (hydrogen index, HI; T50 CH pyrolysis) or long-term (T50 CO2 oxidation and HI) SOC persistence, and that characterize SOM bulk chemical composition (oxygen index, OI and HI), we tested the influence of depth (n = 5), soil class (n = 6) and vegetation type (n = 3; deciduous, coniferous-fir, coniferous-pine) on SOM thermal stability and bulk chemistry. Results showed that depth was the dominant discriminating factor, affecting significantly all RE6 parameters. With depth, we observed a decrease of the thermally labile SOC pool and an increase of the thermally stable SOC pool, along with an oxidation and a depletion of hydrogen-rich moieties of the SOC. Soil class and vegetation type had contrasted effects on the RE6 parameters but both affected significantly T

Comparison Study on Two Model-Based Adaptive Algorithms for SOC Estimation of Lithium-Ion Batteries in Electric Vehicles

Directory of Open Access Journals (Sweden)

Yong Tian

2014-12-01

Full Text Available State of charge (SOC estimation is essential to battery management systems in electric vehicles (EVs to ensure the safe operations of batteries and providing drivers with the remaining range of the EVs. A number of estimation algorithms have been developed to get an accurate SOC value because the SOC cannot be directly measured with sensors and is closely related to various factors, such as ambient temperature, current rate and battery aging. In this paper, two model-based adaptive algorithms, including the adaptive unscented Kalman filter (AUKF and adaptive slide mode observer (ASMO are applied and compared in terms of convergence behavior, tracking accuracy, computational cost and estimation robustness against parameter uncertainties of the battery model in SOC estimation. Two typical driving cycles, including the Dynamic Stress Test (DST and New European Driving Cycle (NEDC are applied to evaluate the performance of the two algorithms. Comparison results show that the AUKF has merits in convergence ability and tracking accuracy with an accurate battery model, while the ASMO has lower computational cost and better estimation robustness against parameter uncertainties of the battery model.

EtherBone - A Network Layer for the Wishbone SoC Bus

CERN Document Server

Kreider, M; Lewis, J; Włostowski, T; Serrano, J

2011-01-01

Today, there are several System on a Chip (SoC) bus systems. Typically, these buses are confined on-chip and rely on higher level components to communicate with the outside world. Taking these systems a step further, we see the possibility of extending the reach of the SoC bus to remote FPGAs or processors. This leads to the idea of the EtherBone (EB) core, which connects a Wishbone (WB) Ver. 4 Bus via a Gigabit Ethernet based network link to remote peripheral devices. EB acts as a transparent interconnect module towards attached WB Bus devices. Address information and data from one or more WB bus cycles is preceded with a descriptive header and encapsulated in a UDP/IP packet. Because of this standard compliance, EB is able to traverse Wide Area Networks and is therefore not bound to a geographic location. Due to the low level nature of the WB bus, EB provides a sound basis for remote hardware tools like a JTAG debugger, In-System-Programmer (ISP), boundary scan interface or logic analyser module. EB was de...

The ubiquitin ligase Cullin5^SOCS2 regulates NDR1/STK38 stability and NF-κB transactivation

DEFF Research Database (Denmark)

Paul, Indranil; Batth, Tanveer S; Iglesias-Gato, Diego

2017-01-01

SOCS2 is a pleiotropic E3 ligase. Its deficiency is associated with gigantism and organismal lethality upon inflammatory challenge. However, mechanistic understanding of SOCS2 function is dismal due to our unawareness of its protein substrates. We performed a mass spectrometry based proteomic pro...

The Tayler instability at low magnetic Prandtl numbers: between chiral symmetry breaking and helicity oscillations

International Nuclear Information System (INIS)

Weber, Norbert; Galindo, Vladimir; Stefani, Frank; Weier, Tom

2015-01-01

The Tayler instability is a kink-type, current driven instability that plays an important role in plasma physics but might also be relevant in liquid metal applications with high electrical currents. In the framework of the Tayler–Spruit dynamo model of stellar magnetic field generation (Spruit 2002 Astron. Astrophys. 381 923–32), the question of spontaneous helical (chiral) symmetry breaking during the saturation of the Tayler instability has received considerable interest (Zahn et al 2007 Astron. Astrophys. 474 145–54; Gellert et al 2011 Mon. Not. R. Astron. Soc. 414 2696–701; Bonanno et al 2012 Phys. Rev. E 86 016313). Focusing on fluids with low magnetic Prandtl numbers, for which the quasistatic approximation can be applied, we utilize an integro-differential equation approach (Weber et al 2013 New J. Phys.15 043034) in order to investigate the saturation mechanism of the Tayler instability. Both the exponential growth phase and the saturated phase are analysed in terms of the action of the α and β effects of mean-field magnetohydrodynamics. In the exponential growth phase we always find a spontaneous chiral symmetry breaking which, however, disappears in the saturated phase. For higher degrees of supercriticality, we observe helicity oscillations in the saturated regime. For Lundquist numbers in the order of one we also obtain chiral symmetry breaking of the saturated magnetic field. (paper)

Induction of CML28-specific cytotoxic T cell responses using co-transfected dendritic cells with CML28 DNA vaccine and SOCS1 small interfering RNA expression vector

International Nuclear Information System (INIS)

Zhou Hongsheng; Zhang Donghua; Wang Yaya; Dai Ming; Zhang Lu; Liu Wenli; Liu Dan; Tan Huo; Huang Zhenqian

2006-01-01

CML28 is an attractive target for antigen-specific immunotherapy. SOCS1 represents an inhibitory control mechanism for DC antigen presentation and the magnitude of adaptive immunity. In this study, we evaluated the potential for inducing CML28-specific cytotoxic T lymphocytes (CTL) responses by dendritic cells (DCs)-based vaccination. We constructed a CML28 DNA vaccine and a SOCS1 siRNA vector and then cotransfect monocyte-derived DCs. Flow cytometry analysis showed gene silencing of SOCS1 resulted in higher expressions of costimulative moleculars in DCs. Mixed lymphocyte reaction (MLR) indicated downregulation of SOCS1 stronger capability to stimulate proliferation of responder cell in DCs. The CTL assay revealed transfected DCs effectively induced autologous CML28-specific CTL responses and the lytic activities induced by SOCS1-silenced DCs were significantly higher compared with those induced by SOCS1-expressing DCs. These results in our study indicates gene silencing of SOCS1 remarkably enhanced the cytotoxicity efficiency of CML28 DNA vaccine in DCs

SOCS proteins in regulation of receptor tyrosine kinase signaling

DEFF Research Database (Denmark)

Kazi, Julhash U.; Kabir, Nuzhat N.; Flores Morales, Amilcar

2014-01-01

Receptor tyrosine kinases (RTKs) are a family of cell surface receptors that play critical roles in signal transduction from extracellular stimuli. Many in this family of kinases are overexpressed or mutated in human malignancies and thus became an attractive drug target for cancer treatment....... The signaling mediated by RTKs must be tightly regulated by interacting proteins including protein-tyrosine phosphatases and ubiquitin ligases. The suppressors of cytokine signaling (SOCS) family proteins are well-known negative regulators of cytokine receptors signaling consisting of eight structurally similar...

IL-8 induces miR-424-5p expression and modulates SOCS2/STAT5 signaling pathway in oral squamous cell carcinoma.

Science.gov (United States)

Peng, Hsuan-Yu; Jiang, Shih-Sheng; Hsiao, Jenn-Ren; Hsiao, Michael; Hsu, Yuan-Ming; Wu, Guan-Hsun; Chang, Wei-Min; Chang, Jang-Yang; Jin, Shiow-Lian Catherine; Shiah, Shine-Gwo

2016-06-01

Suppressor of cytokine signaling (SOCS) proteins are negative feedback regulators of the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway. Dysregulation of SOCS protein expression in cancers can be one of the mechanisms that maintain STAT activation, but this mechanism is still poorly understood in oral squamous cell carcinoma (OSCC). Here, we report that SOCS2 protein is significantly downregulated in OSCC patients and its levels are inversely correlated with miR-424-5p expression. We identified the SOCS2 protein, which modulates STAT5 activity, as a direct target of miR-424-5p. The miR-424-5p-induced STAT5 phosphorylation, matrix metalloproteinases (MMPs) expression, and cell migration and invasion were blocked by SOCS2 restoration, suggesting that miR-424-5p exhibits its oncogenic activity through negatively regulating SOCS2 levels. Furthermore, miR-424-5p expression could be induced by the cytokine IL-8 primarily through enhancing STAT5 transcriptional activity rather than NF-κB signaling. Antagomir-mediated inactivation of miR-424-5p prevented the IL-8-induced cell migration and invasion, indicating that miR-424-5p is required for IL-8-induced cellular invasiveness. Taken together, these data indicate that STAT5-dependent expression of miR-424-5p plays an important role in mediating IL-8/STAT5/SOCS2 feedback loop, and scavenging miR-424-5p function using antagomir may have therapeutic potential for the treatment of OSCC. Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.

SoCRocket: A Virtual Platform for SoC Design

Science.gov (United States)

Fossati, Luca; Schuster, Thomas; Meyer, Rolf; Berekovic, Mladen

2013-08-01

Both in the commercial and in the aerospace domain, the continuous increase of transistor density on a single die is leading towards the production of more and more complex systems on a single chip, with an increasing number of components. This brought to the introduction of the System-On-Chip (SoC) architecture, that integrates on a single circuit all the elements of a full system. This strive for efficient utilization of the available silicon has triggered several paradigm shifts in system design. Similarly to what happened in the early 1990s, when VHDL and Verilog took over from schematic design, today SystemC and Transaction Level Modeling [1] are about to further raise the design abstraction level. Such descriptions have to be accurate enough to describe the entire system throughout the phases of its development, and has to provide enough flexibility to be refined iteratively up to the point where the actual device can be produced using current process technology. Besides requiring new languages and methodologies, the complexity of current and future SoCs (SCOC3 [16] and NGMP [5] are example in the space domain) forces the SoC design process to rely on pre-designed or third party components. Components obtained from different providers, and even those designed by different teams of the same company, may be heterogeneous on several aspects: design domains, interfaces, abstraction levels, granularity, etc. Therefore, component integration is required at system level. Only by applying design re-use it is possible to successfully and timely design such complex SoCs. This transition to new languages and design methods is also motivated by the implementation with software of an increasing amount of system functionalities. Hence the need for methodologies to enable early software development and which allow the analysis of the performance of the combined Hw/Sw system, as their design and configuration cannot be performed separately. Virtual Prototyping is a key

LOSS OF JAK2 REGULATION VIA VHL-SOCS1 E3 UBIQUITIN HETEROCOMPLEX UNDERLIES CHUVASH POLYCYTHEMIA

Science.gov (United States)

Russell, Ryan C.; Sufan, Roxana I.; Zhou, Bing; Heir, Pardeep; Bunda, Severa; Sybingco, Stephanie S.; Greer, Samantha N.; Roche, Olga; Heathcote, Samuel A.; Chow, Vinca W.K.; Boba, Lukasz M.; Richmond, Terri D.; Hickey, Michele M.; Barber, Dwayne L.; Cheresh, David A.; Simon, M. Celeste; Irwin, Meredith S.; Kim, William Y.; Ohh, Michael

2011-01-01

SUMMARY Chuvash polycythemia (CP) is a rare congenital form of polycythemia caused by homozygous R200W and H191D mutations in the von Hippel-Lindau (VHL) gene whose gene product is the principal negative regulator of hypoxia-inducible factor. However, the molecular mechanisms underlying some of the hallmark features of CP such as hypersensitivity to erythropoietin are unclear. Here, we show that VHL directly binds suppressor of cytokine signalling 1 (SOCS1) to form a heterodimeric E3 ligase that targets phosphorylated (p)JAK2 for ubiquitin-mediated destruction. In contrast, CP-associated VHL mutants have altered affinity for SOCS1 and fail to engage and degrade pJAK2. Systemic administration of a highly selective JAK2 inhibitor, TG101209, reverses the disease phenotype in vhlR200W/R200W knock-in mice, a model that faithfully recapitulates human CP. These results reveal VHL as a SOCS1-cooperative negative regulator of JAK2 and provide compelling biochemical and preclinical evidence for JAK2- targeted therapy in CP patients. PMID:21685897

Molecular Cloning, Characterization, and Expression of MiSOC1: A Homolog of the Flowering Gene SUPPRESSOR OF OVEREXPRESSION OF CONSTANS1 from Mango (Mangifera indica L)

Science.gov (United States)

Wei, Junya; Liu, Debing; Liu, Guoyin; Tang, Jie; Chen, Yeyuan

2016-01-01

MADS-box transcription factor plays a crucial role in plant development, especially controlling the formation and development of floral organs. Mango (Mangifera indica L) is an economically important fruit crop, but its molecular control of flowering is largely unknown. To better understand the molecular basis of flowering regulation in mango, we isolated and characterized the MiSOC1, a putative mango orthologs for the Arabidopsis SUPPRESSOR OF OVEREXPRESSION OF CONSTANS1/AGAMOUS-LIKE 20 (SOC1/AGL20) with homology-based cloning and RACE. The full-length cDNA (GenBank accession No.: KP404094) is 945 bp in length including a 74 bp long 5′ UTR and a 189 bp long 3′ UTR and the open reading frame was 733 bps, encoding 223 amino acids with molecular weight 25.6 kD. Both sequence alignment and phylogenetic analysis all indicated that deduced protein contained a conservative MADS-box and semi-conservative K domain and belonged to the SOC1/TM3 subfamily of the MADS-box family. Quantitative real-time PCR was performed to investigate the expression profiles of MiSOC1 gene in different tissues/organs including root, stem, leaves, flower bud, and flower. The result indicated MiSOC1 was widely expressed at different levels in both vegetative and reproductive tissues/organs with the highest expression level in the stems’ leaves and inflorescences, low expression in roots and flowers. The expression of MiSOC1 in different flower developmental stages was different while same tissue –specific pattern among different varieties. In addition, MiSOC1 gene expression was affect by ethephon while high concentration ethephon inhibit the expression of MiSOC1. Overexpression of MiSOC1 resulted in early flowering in Arabidopsis. In conclusion, these results suggest that MiSOC1 may act as induce flower function in mango. PMID:27965680

Molecular Cloning, Characterization, and Expression of MiSOC1: A Homolog of the Flowering Gene SUPPRESSOR OF OVEREXPRESSION OF CONSTANS1 from Mango (Mangifera indica L).

Science.gov (United States)

Wei, Junya; Liu, Debing; Liu, Guoyin; Tang, Jie; Chen, Yeyuan

2016-01-01

MADS-box transcription factor plays a crucial role in plant development, especially controlling the formation and development of floral organs. Mango ( Mangifera indica L) is an economically important fruit crop, but its molecular control of flowering is largely unknown. To better understand the molecular basis of flowering regulation in mango, we isolated and characterized the MiSOC1, a putative mango orthologs for the Arabidopsis SUPPRESSOR OF OVEREXPRESSION OF CONSTANS1/AGAMOUS-LIKE 20 (SOC1/AGL20) with homology-based cloning and RACE. The full-length cDNA (GenBank accession No.: KP404094) is 945 bp in length including a 74 bp long 5' UTR and a 189 bp long 3' UTR and the open reading frame was 733 bps, encoding 223 amino acids with molecular weight 25.6 kD. Both sequence alignment and phylogenetic analysis all indicated that deduced protein contained a conservative MADS-box and semi-conservative K domain and belonged to the SOC1/TM3 subfamily of the MADS-box family. Quantitative real-time PCR was performed to investigate the expression profiles of MiSOC1 gene in different tissues/organs including root, stem, leaves, flower bud, and flower. The result indicated MiSOC1 was widely expressed at different levels in both vegetative and reproductive tissues/organs with the highest expression level in the stems' leaves and inflorescences, low expression in roots and flowers. The expression of MiSOC1 in different flower developmental stages was different while same tissue -specific pattern among different varieties. In addition, MiSOC1 gene expression was affect by ethephon while high concentration ethephon inhibit the expression of MiSOC1. Overexpression of MiSOC1 resulted in early flowering in Arabidopsis . In conclusion, these results suggest that MiSOC1 may act as induce flower function in mango.

Rapid Development of System-on-Chip (SoC for Network-Enabled Visible Light Communications

Directory of Open Access Journals (Sweden)

Trio Adiono

2018-03-01

Full Text Available Visible Light Communication (VLC is an emerging optical communication technology with rapid development nowadays. VLC is considered as a compliment and successor of radio-frequency (RF wireless communication. There are various typical implementations of VLC in which one of them is for exchanging data TCP/IP packets, thus the user can browse the internet as in established Wireless fidelity (Wi-Fi technology. Briefly, we can call it by Light fidelity (Li-Fi. This paper described the design and implementation of System-on-Chip (SoC subsystem for Li-Fi application where the implemented SoC consists of hardware (H/W and software (S/W. In the H/W aspect, Physical Layer (PHY is made by using UART communication with Ethernet connection to communicate with Host/Device personal-computer (PC. In the S/W aspect, Xillinux operating system (OS is used. The H/W- as well as S/W-SoC, are realized in FPGA Zybo Zynq-7000 EPP development board. The functional test result shows (without optical channel or Zybo-to-Zybo only that the implemented SoC is working as expected. It is able to exchange TCP/IP packets between two PCs. Moreover, Ethernet connection has bandwidth up to 83.6 Mbps and PHY layer baud rate has bandwidth up to 921600 bps.

Common variants in SOCS7 gene predict obesity, disturbances in lipid metabolism and insulin resistance.

Science.gov (United States)

Tellechea, M L; Steinhardt, A Penas; Rodriguez, G; Taverna, M J; Poskus, E; Frechtel, G

2013-05-01

Specific Suppressor of Cytokine Signaling (SOCS) members, such as SOCS7, may play a role in the development of insulin resistance (IR) owing to their ability to inhibit insulin signaling pathways. The objective was to explore the association between common variants and related haplotypes in SOCS7 gene and metabolic traits related to obesity, lipid metabolism and IR. 780 unrelated men were included in a cross-sectional study. We selected three tagged SNPs that capture 100% of SNPs with minor allele frequency ≥ 0.10. Analyses were done separately for each SNP and followed up by haplotype analysis. rs8074124C was associated with both obesity (p = 0.005) and abdominal obesity (p = 0.002) and allele C carriers showed, in comparison with TT carriers, lower BMI (p = 0.001) and waist circumference (p = 0.001). rs8074124CC- carriers showed lower fasting insulin (p = 0.017) and HOMA-IR (p = 0.018) than allele T carriers. rs12051836C was associated with hypertriglyceridemia (p = 0.009) and hypertriglyceridemic waist (p = 0.006). rs12051836CC- carriers showed lower fasting insulin (p = 0.043) and HOMA-IR (p = 0.042). Haplotype-based association analysis (rs8074124 and rs12051836 in that order) showed associations with lipid and obesity -related phenotypes, consistent with single locus analysis. Haplotype analysis also revealed association between haplotype CT and both decreased HDL-C (p = 0.026) and HDL-C (p = 0.014) as a continuous variable. We found, for the first time, significant associations between SOCS7 common variants and related haplotypes and obesity, IR and lipid metabolism disorders. Crown Copyright © 2011. Published by Elsevier B.V. All rights reserved.

Monolithic distributed power management for systems-on-chip (SoC); Gestion monolithique distribuee de puissance pour les systemes sur puce (SOC)

Energy Technology Data Exchange (ETDEWEB)

Abedinpour, S. [Motorola, Semiconductor Products Sector, Tempe (United States); Bakkaloglu, B. [Texas Instruments, Broadband Communications Group, Dallas, Texas (United States); Kiaei, S. [Arizona State Univ., Connection one Research Center, Tempe (United States)

2004-08-01

With increasing drive towards higher level of integration, lower cost, and longer battery life in wireless applications, there is a need for efficient monolithic DC-DC power converters. This tutorial paper summarizes the topology tradeoffs that are involved in the implementation of monolithic distributed power management in the future generations of SoCs for portable wireless applications. These circuits have a broad range of requirements including high power density, high energy efficiency, low noise, small size, and low cost. The advantages and disadvantages of each of the competing topologies, namely low-dropout linear, switched capacitor, and switched-mode DC-DC converters are examined in light of these requirements. (authors)

Effects of land use change and management on SOC and soil quality in Mediterranean rangelands areas

Science.gov (United States)

Parras-Alcántara, Luis; Lozano-García, Beatriz; Requejo, Ana; Zornoza, Raúl

2017-04-01

INTRODUCTION Rangelands in the Iberian Peninsula occupy more than 90,000 km2. These rangelands were created from the former Mediterranean oak forests, mainly composed of holm oak and cork oak (Quercus ilex rotundifolia and Quercus suber), by clear-cutting shrubs, removing selected trees and cultivating. These man-made landscapes are called 'dehesas' in Spain and 'montados' in Portugal. Between 1955 and 1981, more than 5,000 km2 of dehesas was converted from pastureland to cultivated land. This process has been accelerated since 1986 owing to subsidies from the European Common Agricultural Policy (Parras-Alcántara et al., 2015a). The role that natural rangelands play in the global carbon cycle is extremely important, accounting for 10-30% of the world's total soil organic carbon (SOC), in addition, SOC concentration is closely related to soil quality and vegetation productivity (Brevik, 2012). Therefore, to study the land use and management changes is important, particularly in Mediterranean soils, as they are characterized by low organic carbon content, furthermore, the continuous use of ploughing for grain production is the principal cause of soil degradation. Therefore, land use decisions and management systems can increase or decrease SOC content and stock (Corral-Fernández et al., 2013; Parras-Alcántara et al., 2014, 2015a and 2015b; Parras-Alcántara and Lozano-García, 2014) MATERIAL AND METHODS A field study was conducted to determine the land use change (Mediterranean evergreen oak woodland to olive grove and cereal, all of them managed under conventional tillage and under conservationist practices) effects on SOC stocks and the soil quality (Stratification Ratio) in Los Pedroches valley, southern Spain. RESULTS Results for the present study indicate that management practices had little effect on SOC storage in dehesas. The stratification ratio was >2 both under conventional tillage and under organic farming, so, soils under dehesa had high quality

Suppressor of cytokine signaling 2 (Socs2 deletion protects bone health of mice with DSS-induced inflammatory bowel disease

Directory of Open Access Journals (Sweden)

Ross Dobie

2018-01-01

Full Text Available Individuals with inflammatory bowel disease (IBD often present with poor bone health. The development of targeted therapies for this bone loss requires a fuller understanding of the underlying cellular mechanisms. Although bone loss in IBD is multifactorial, the altered sensitivity and secretion of growth hormone (GH and insulin-like growth factor-1 (IGF-1 in IBD is understood to be a critical contributing mechanism. The expression of suppressor of cytokine signaling 2 (SOCS2, a well-established negative regulator of GH signaling, is stimulated by proinflammatory cytokines. Therefore, it is likely that SOCS2 expression represents a critical mediator through which proinflammatory cytokines inhibit GH/IGF-1 signaling and decrease bone quality in IBD. Using the dextran sodium sulfate (DSS model of colitis, we reveal that endogenously elevated GH function in the Socs2−/− mouse protects the skeleton from osteopenia. Micro-computed tomography assessment of DSS-treated wild-type (WT mice revealed a worsened trabecular architecture compared to control mice. Specifically, DSS-treated WT mice had significantly decreased bone volume, trabecular thickness and trabecular number, and a resulting increase in trabecular separation. In comparison, the trabecular bone of Socs2-deficient mice was partially protected from the adverse effects of DSS. The reduction in a number of parameters, including bone volume, was less, and no changes were observed in trabecular thickness or separation. This protected phenotype was unlikely to be a consequence of improved mucosal health in the DSS-treated Socs2−/− mice but rather a result of unregulated GH signaling directly on bone. These studies indicate that the absence of SOCS2 is protective against bone loss typical of IBD. This study also provides an improved understanding of the relative effects of GH/IGF-1 signaling on bone health in experimental colitis, information that is essential before these drugs are

Performance Evaluation of FIR Filter After Implementation on Different FPGA and SOC and Its Utilization in Communication and Network

DEFF Research Database (Denmark)

Pandey, Bishwajeet; Das, Bhagwan; Kaur, Amanpreet

2017-01-01

that will energy efficient as well as faster than traditional design. Three different FPGA and SOC are taken under consideration and our design is implemented on these four ICs and we find the most energy efficient architecture and also find the architecture that will deliver highest performance among these four...... FPGA then we conclude that Zynq 7000 All programmable SOC is power hungry architecture and Kintex ultrascale architecture is the most energy efficient architecture that dissipates 20.86% less power than Zynq 700 All programmable SOC. For performance evaluation, we have taken benchmark C code of FIR...... provide by Xilinx. We transform that C code into HDL using Vivado HLS 2016.2 before power analysis on Vivado 2016.2. Ultrascale FPGA is generally used for packet processing in 100G networking and heterogeneous wireless infrastructure....

Effects of different soil types in natural Mediterranean areas on soil organic carbon (SOC)

Science.gov (United States)

Requejo Silva, Ana; Lozano García, Beatriz; Parras Alcántara, Luis

2017-04-01

Effects of different soil types in natural Mediterranean areas on soil organic carbon (SOC) Ana Requejo1, Beatriz Lozano-García1, Luis Parras Alcántara1 1 Department of Agricultural Chemistry and Soil Science, Faculty of Science, Agrifood Campus of International Excellence - ceiA3, University of Córdoba, Spain. The carbon content of the atmosphere can be influenced by soils, since they can store carbon or emit large quantities of CO2. C sequestration into soils is one of the most important ecosystems services because of its role in climate regulation (IPPC, 2007). Thereof, agriculture and forestry are the only activities that can contribute to C sequestration through photosynthesis and its carbon incorporation into carbohydrates (Parras Alcántara et al., 2013). Dehesa is a multifunctional agro-sylvo-pastoral system and typical landscape of southern and central Spain and southern Portugal. It is an anthropogenic system dedicated to the combined production of black iberian pigs, a variety of foods, fuel, coal, and cork. Besides, it acts as well in the production of endangered species as wildlife habitat and as sustainable hunting areas. These dehesa areas are defined by a relationship between productivity and conservation of forest oaks, providing environmental benefits such as carbon capture and storage. The area focused in this study is the Cardeña-Montoro Nature Reserve, located within the Sierra Morena (Córdoba, South Spain). The most representative soils in Cardeña-Montoro Nature Reserve are Cambisols, Regosols, Leptosols and Fluvisols according to IUSS Working Group WRB (2006). They are characterized by a low fertility, poor physical conditions and marginal capacity for agricultural use, along with low organic matter content due to climate conditions (semiarid Mediterranean climate) and soil texture (sandy). Several studies have shown that land use affects the SOC concentration (Lozano-García et al., 2016; Khaledian et al., 2016). Based on this

Strong lensing probability in TeVeS (tensor-vector-scalar) theory

Science.gov (United States)

Chen, Da-Ming

2008-01-01

We recalculate the strong lensing probability as a function of the image separation in TeVeS (tensor-vector-scalar) cosmology, which is a relativistic version of MOND (MOdified Newtonian Dynamics). The lens is modeled by the Hernquist profile. We assume an open cosmology with Ωb = 0.04 and ΩΛ = 0.5 and three different kinds of interpolating functions. Two different galaxy stellar mass functions (GSMF) are adopted: PHJ (Panter, Heavens and Jimenez 2004 Mon. Not. R. Astron. Soc. 355 764) determined from SDSS data release 1 and Fontana (Fontana et al 2006 Astron. Astrophys. 459 745) from GOODS-MUSIC catalog. We compare our results with both the predicted probabilities for lenses from singular isothermal sphere galaxy halos in LCDM (Lambda cold dark matter) with a Schechter-fit velocity function, and the observational results for the well defined combined sample of the Cosmic Lens All-Sky Survey (CLASS) and Jodrell Bank/Very Large Array Astrometric Survey (JVAS). It turns out that the interpolating function μ(x) = x/(1+x) combined with Fontana GSMF matches the results from CLASS/JVAS quite well.

ETHERBONE - a network layer for the wishbone SoC bus

International Nuclear Information System (INIS)

Kreider, M.; Terpstra, W.; Lewis, J.; Serrano, J.; Wlostowski, T.

2012-01-01

Today, there are several System on a Chip (SoC) bus systems. Typically, these buses are confined on-chip and rely on higher level components to communicate with the outside world. Taking these systems a step further, we see the possibility of extending the reach of the SoC bus to remote FPGAs or processors. This leads to the idea of the EtherBone (EB) core, which connects a Wishbone (WB) Ver. 4 Bus via a Gigabit Ethernet based network link to remote peripheral devices. EB acts as a transparent interconnect module towards attached WB Bus devices. Address information and data from one or more WB bus cycles is preceded with a descriptive header and encapsulated in a UDP/IP packet. Because of this standard compliance, EB is able to traverse Wide Area Networks and is therefore not bound to a geographic location. Due to the low level nature of the WB bus, EB provides a sound basis for remote hardware tools like a JTAG debugger, In-System-Programmer (ISP), boundary scan interface or logic analyser module. EB was developed in the scope of the White-Rabbit Timing Project (WR) at CERN and GSI/FAIR, which employs GigaBit Ethernet technology to communicate with memory mapped slave devices. WR will make use of EB as means to issue commands to its timing nodes and control connected accelerator hardware. (authors)

Detecting small-scale spatial heterogeneity and temporal dynamics of soil organic carbon (SOC) stocks: a comparison between automatic chamber-derived C budgets and repeated soil inventories

Science.gov (United States)

Hoffmann, Mathias; Jurisch, Nicole; Garcia Alba, Juana; Albiac Borraz, Elisa; Schmidt, Marten; Huth, Vytas; Rogasik, Helmut; Rieckh, Helene; Verch, Gernot; Sommer, Michael; Augustin, Jürgen

2017-03-01

Carbon (C) sequestration in soils plays a key role in the global C cycle. It is therefore crucial to adequately monitor dynamics in soil organic carbon (ΔSOC) stocks when aiming to reveal underlying processes and potential drivers. However, small-scale spatial (10-30 m) and temporal changes in SOC stocks, particularly pronounced in arable lands, are hard to assess. The main reasons for this are limitations of the well-established methods. On the one hand, repeated soil inventories, often used in long-term field trials, reveal spatial patterns and trends in ΔSOC but require a longer observation period and a sufficient number of repetitions. On the other hand, eddy covariance measurements of C fluxes towards a complete C budget of the soil-plant-atmosphere system may help to obtain temporal ΔSOC patterns but lack small-scale spatial resolution. To overcome these limitations, this study presents a reliable method to detect both short-term temporal dynamics as well as small-scale spatial differences of ΔSOC using measurements of the net ecosystem carbon balance (NECB) as a proxy. To estimate the NECB, a combination of automatic chamber (AC) measurements of CO2 exchange and empirically modeled aboveground biomass development (NPPshoot) were used. To verify our method, results were compared with ΔSOC observed by soil resampling. Soil resampling and AC measurements were performed from 2010 to 2014 at a colluvial depression located in the hummocky ground moraine landscape of northeastern Germany. The measurement site is characterized by a variable groundwater level (GWL) and pronounced small-scale spatial heterogeneity regarding SOC and nitrogen (Nt) stocks. Tendencies and magnitude of ΔSOC values derived by AC measurements and repeated soil inventories corresponded well. The period of maximum plant growth was identified as being most important for the development of spatial differences in annual ΔSOC. Hence, we were able to confirm that AC-based C budgets are able

Calcineurin inhibitor-induced complement system activation via ERK1/2 signalling is inhibited by SOCS-3 in human renal tubule cells.

Science.gov (United States)

Loeschenberger, Beatrix; Niess, Lea; Würzner, Reinhard; Schwelberger, Hubert; Eder, Iris E; Puhr, Martin; Guenther, Julia; Troppmair, Jakob; Rudnicki, Michael; Neuwirt, Hannes

2018-02-01

One factor that significantly contributes to renal allograft loss is chronic calcineurin inhibitor (CNI) nephrotoxicity (CIN). Among other factors, the complement (C-) system has been proposed to be involved CIN development. Hence, we investigated the impact of CNIs on intracellular signalling and the effects on the C-system in human renal tubule cells. In a qPCR array, CNI treatment upregulated C-factors and downregulated SOCS-3 and the complement inhibitors CD46 and CD55. Additionally, ERK1/-2 was required for these regulations. Following knock-down and overexpression of SOCS-3, we found that SOCS-3 inhibits ERK1/-2 signalling. Finally, we assessed terminal complement complex formation, cell viability and apoptosis. Terminal complement complex formation was induced by CNIs. Cell viability was significantly decreased, whereas apoptosis was increased. Both effects were reversed under complement component-depleted conditions. In vivo, increased ERK1/-2 phosphorylation and SOCS-3 downregulation were observed at the time of transplantation in renal allograft patients who developed a progressive decline of renal function in the follow-up compared to stable patients. The progressive cohort also had lower total C3 levels, suggesting higher complement activity at baseline. In conclusion, our data suggest that SOCS-3 inhibits CNI-induced ERK1/-2 signalling, thereby blunting the negative control of C-system activation. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Qual o Papel da Escola e da Mídia na Obtenção dos Conhecimentos Astronômicos?

Science.gov (United States)

da Cunha, W. S.; Voelzke, M. R.; Amaral, L. H.

2007-08-01

É amplamente reconhecido que as pessoas em geral têm grande fascínio e interesse pela Astronomia. Por outro lado, o conteúdo dessa área incluído no ensino formal está longe de ser abrangente e suficiente para suprir a demanda. Esse interesse permite aperfeiçoar a divulgação e o ensino não formal de Astronomia através da mídia aliando a adequação do conteúdo à expectativa das pessoas. A reforma do Currículo Básico da Escola Pública da maioria dos Estados brasileiros tem introduzido Astronomia desde a pré-escola até o Ensino Médio. Num estudo realizado com 1180 alunos do Ensino Médio de seis escolas estaduais, revelou-se através da aplicação de um formulário contendo questões que abordavam conhecimentos básicos em Astronomia, como foram adquiridos tais conhecimentos e à infra-estrutura da escola. Para 66,1% dos entrevistados o professor já fez alguma apresentação a respeito de Astronomia. O presente estudo revelou também que 54,4% dos alunos entrevistados adquiriram seus conhecimentos astronômicos na escola, 18,4% através da televisão e 27,1% afirmaram que seus conhecimentos foram obtidos através de outros tipos de mídia (internet, livros didáticos, filmes e revistas). Embora o estudo revele claramente que há certo equilíbrio no meio em que os alunos obtiveram seus conhecimentos astronômicos, a mídia busca não somente sua difusão, mas a disponibilização desse conhecimento de maneira correta, que às vezes, não é atingido, apresentando conceitos sem fundamentação e incorretos. Por outro lado, no dia-a-dia escolar, é comum encontrar professores que vêm para as aulas com concepções prévias, que podem diferir substancialmente das idéias a serem ensinadas, dificultando o aprendizado de futuros conceitos científicos. Uma avaliação criteriosa, avaliando as dificuldades dos professores em determinar o sentido correto dos conceitos e observando a metodologia que utilizam no ensino, poderá proporcionar uma melhor

DMA Controller for LEON3 SoC:s Using AMBA

OpenAIRE

Nilsson, Emelie

2013-01-01

A DMA Controller can offload a processor tremendously. A memory copy operation can be initiated by the processor and while the processor executes others tasks the memory copy can be fulfilled by the DMA Controller. An implementation of a DMA Controller for use in LEON3 SoC:s has been made during this master thesis. Problems that occurred while designing a controller of this type concerned AMBA buses, data transfers, alignment and interrupt handling. The DMA Controller supports AMBA and is att...

Overexpression of DOSOC1, an ortholog of Arabidopsis SOC1, promotes flowering in the orchid Dendrobium Chao Parya Smile.

Science.gov (United States)

Ding, Lihua; Wang, Yanwen; Yu, Hao

2013-04-01

SUPPRESSOR OF OVEREXPRESSION OF CONSTANS1 (SOC1) encodes a MADS-box protein that plays an essential role in integrating multiple flowering signals to regulate the transition from vegetative to reproductive development in the model plant Arabidopsis. Although SOC1-like genes have been isolated in various angiosperms, its orthologs in Orchidaceae, one of the largest families of flowering plants, are so far unknown. To investigate the regulatory mechanisms of flowering time control in orchids, we isolated a SOC1-like gene, DOSOC1, from Dendrobium Chao Praya Smile. DOSOC1 was highly expressed in reproductive organs, including inflorescence apices, pedicels, floral buds and open flowers. Its expression significantly increased in whole plantlets during the transition from vegetative to reproductive development, which usually occurred after 8 weeks of culture in Dendrobium Chao Praya Smile. In the shoot apex at the floral transitional stage, DOSOC1 was particularly expressed in emerging floral meristems. Overexpression of DOSOC1 in wild-type Arabidopsis plants resulted in early flowering, which was coupled with the up-regulation of two other flowering promoters, AGAMOUS-LIKE 24 and LEAFY. In addition, overexpression of DOSOC1 was able partially to complement the late-flowering phenotype of Arabidopsis soc1-2 loss-of-function mutants. Furthermore, we successfully created seven 35S:DOSOC1 transgenic Dendrobium orchid lines, which consistently exhibited earlier flowering than wild-type orchids. Our results suggest that SOC1-like genes play an evolutionarily conserved role in promoting flowering in the Orchidaceae family, and that DOSOC1 isolated from Dendrobium Chao Praya Smile could serve as an important target for genetic manipulation of flowering time in orchids.

Assessment of LabSOCS as a tool for the calculation of self-attenuation coefficients in gamma spectrometry

Energy Technology Data Exchange (ETDEWEB)

Lopes, J.; De Medeiros, M. P.; Garcez, R.; Filgueiras, R.; Thalhofer, J.; Da Silva, A. X. [Universidade Federal do Rio de Janeiro, Programa de Engenharia Nuclear, Av. Horacio Macedo 2030, 21945-970 Rio de Janeiro (Brazil); Freitas R, W., E-mail: marqueslopez@yahoo.com.br [Instituto Militar de Engenharia, Secao de Engenharia Nuclear, Praca Gen. Tiburcio 80, 22290-270 Urca, Rio de Janeiro (Brazil)

2017-10-15

In spectrometry, the self-attenuation coefficients are fundamental to correct the efficiency of the detection of samples whose density is different from the radioactive standard. To facilitate the procedure of coefficient calculation, mathematical simulations have been widespread as a tool. In this paper, LabSOCS was used to calculate the self-attenuation coefficients for some geometries and the values found were compared to those obtained with MCNPX and experimental values. The percentage deviations found for the self-attenuation coefficient calculated by LabSOCS were below 1.6%, when compared to experimental values. In the extrapolation zone of the fitting curve of the experimental model, the deviations were below 1.9%. The results obtained show that the deviations increase proportionally to the amplitude between the density values of the radioactive standard and the sample. High percentage deviations were also obtained in simulations whose samples had high densities, complex geometries and low energy levels. However, the results indicate that LabSOCS is a tool which may be used in the calculation of self-attenuation coefficients. (Author)

Neighborhood-resources for the development of a strong SOC and the importance of understanding why and how resources work: a grounded theory approach.

Science.gov (United States)

Maass, Ruca; Lindström, Bengt; Lillefjell, Monica

2017-09-12

Providing individuals with psychosocial resources such as sense of coherence (SOC) seems a beneficial strategy for health promotion in the neighborhood. In order to become a supporting theory for health promotion, Salutogenesis should renew its focus on resources for health, and explore how the development of a strong SOC can be facilitated. Relevant issues were explored using a Grounded Theory- approach. Three focus-group-sessions and three in-depth interviews were conducted with strategically sampled participants. The transcripts of the focus groups were initially analyzed line-by-line to ensure that insights emerged from the data. We then applied focused and systemic analyses to achieve axial coding, and to include insights into how social interactions during focus groups may reveal social processes in real-life-neighborhoods. The data from the in-depth interviews were used to validate and fill emerging categories, as well as to ensure data-saturation. Findings indicate the importance of repeated experiences with resources and every-day-challenges to develop a strong SOC. Active engagement with resources is a favorable condition for significant experiences, which enhance the internalization of resources. Core experiences are characterized by a re-organization of resources. Participation in intellectual meaning-making through equal power dialogue seems to broaden perspectives and promote the strengthening of SOC. A strong SOC can also be described as a deeper understanding of how and why resources work, which allows for a more flexible use of resources, including replacing missing resources. A new understanding of SOC as an intuitive understanding of how, why and under which circumstances resources work, as well as a new focus on everyday life and repeated experiences might facilitate new approaches to a purposeful strengthening of SOC through the planning and implementation of public measures.

The fate of SOC during the processes of water erosion and subsequent deposition: a field study.

Science.gov (United States)

van Hemelryck, H.; Govers, G.; van Oost, K.; Merckx, R.

2009-04-01

Globally soils are the largest terrestrial pool of carbon (C). A relatively small increase or decrease in soil carbon content due to changes in land use or management practices could therefore result in a significant net exchange of C between the soil C reservoir and the atmosphere. As such, the geomorphic processes of water and tillage erosion have been identified to significantly impact on this large pool of soil organic carbon (SOC). Soil erosion, transport and deposition not only result in redistribution of sediments and associated carbon within a landscape, but also affect the exchange of C between the pedosphere and the atmosphere. The direction and magnitude of an erosion-induced change in the global C balance is however a topic of much debate as opposing processes interact: i) At eroding sites a net uptake of C could be the result of reduced respiration rates and continued inputs of newly produced carbon. ii) Colluvial deposition of eroded sediment and SOC leads to the burial of the original topsoil and this may constrain the decomposition of its containing SOC. iii) Eroded sediment could be transported to distal depositional environments or fluvial systems where it will either be conserved or become rapidly mineralized. iv) Increased emission of CO2 due to erosion may result from the disruptive energy of erosive forces causing the breakdown of aggregates and exposing previously protected SOC to microbial decomposition. The above-mentioned processes show a large spatial and temporal variability and assessing their impact requires an integrated modeling approach. However uncertainties about the basic processes that accompany SOC displacement are still large. This study focuses on one of these large information gaps: the fate of eroded and subsequently deposited SOC. A preceding experimental study (Van Hemelryck et al., 2008) was used to identify controlling factors (erosional intensity, changes in soil structure,…). However this experimental research

Detecting small-scale spatial differences and temporal dynamics of soil organic carbon (SOC) stocks: a comparison between automatic chamber-derived C budgets and repeated soil inventories

Science.gov (United States)

Hoffmann, Mathias; Jurisch, Nicole; Garcia Alba, Juana; Albiac Borraz, Elisa; Schmidt, Marten; Huth, Vytas; Rogasik, Helmut; Rieckh, Helene; Verch, Gernot; Sommer, Michael; Augustin, Jürgen

2017-04-01

Carbon (C) sequestration in soils plays a key role in the global C cycle. It is therefore crucial to adequately monitor dynamics in soil organic carbon (ΔSOC) stocks when aiming to reveal underlying processes and potential drivers. However, small-scale spatial and temporal changes in SOC stocks, particularly pronounced on arable lands, are hard to assess. The main reasons for this are limitations of the well-established methods. On the one hand, repeated soil inventories, often used in long-term field trials, reveal spatial patterns and trends in ΔSOC but require a longer observation period and a sufficient number of repetitions. On the other hand, eddy covariance measurements of C fluxes towards a complete C budget of the soil-plant-atmosphere system may help to obtain temporal ΔSOC patterns but lack small-scale spatial resolution. To overcome these limitations, this study presents a reliable method to detect both short-term temporal as well as small-scale spatial dynamics of ΔSOC. Therefore, a combination of automatic chamber (AC) measurements of CO2 exchange and empirically modeled aboveground biomass development (NPPshoot) was used. To verify our method, results were compared with ΔSOC observed by soil resampling. AC measurements were performed from 2010 to 2014 under a silage maize/winter fodder rye/sorghum-Sudan grass hybrid/alfalfa crop rotation at a colluvial depression located in the hummocky ground moraine landscape of NE Germany. Widespread in large areas of the formerly glaciated Northern Hemisphere, this depression type is characterized by a variable groundwater level (GWL) and pronounced small-scale spatial heterogeneity in soil properties, such as SOC and nitrogen (Nt). After monitoring the initial stage during 2010, soil erosion was experimentally simulated by incorporating topsoil material from an eroded midslope soil into the plough layer of the colluvial depression. SOC stocks were quantified before and after soil manipulation and at the end

Metal–organic frameworks to satisfy gas upgrading demands: fine-tuning the soc-MOF platform for the operative removal of H2S

KAUST Repository

Belmabkhout, Youssef

2017-01-06

A cooperative experimental/modeling strategy was used to unveil the structure/gas separation performance relationship for a series of isostructural metal-organic frameworks (MOFs) with soc-topology (square-octahedral) hosting different extra-framework counter ions (NO3-, Cl- and Br-). In3+-, Fe3+-, Ga3+-and the newly isolated Al(III)-based isostructural soc-MOF were extensively studied and evaluated for the separation-based production of high-quality fuels (i.e., CH4, C3H8 and n-C4H10) and olefins. The structural/chemical fine-tuning of the soc-MOF platform promoted equilibrium-based selectivity toward C2+ (C2H6, C2H4, C3H6 C3H8 and n-C4H10) and conferred the desired chemical stability toward H2S. The noted dual chemical stability and gas/vapor selectivity, which have rarely been reported for equilibrium-based separation agents, are essential for the production of high-purity H-2, CH4 and C2+ fractions in high yields. Interestingly, the evaluated soc-MOF analogues exhibited high selectivity for C2H4, C3H6 and n-C4H10. In particular, the Fe, Ga and Al analogues presented relatively enhanced C2+/CH4 adsorption selectivities. Notably, the Ga and Al analogues were found to be technically preferable because their structural integrities and separation performances were maintained upon exposure to H2S, indicating that these materials are highly tolerant to H2S. Therefore, the Ga-soc-MOF was further examined for the selective adsorption of H2S in the presence of CO2-and CH4-containing streams, such as refinery-off gases (ROG) and natural gas (NG). Grand canonical Monte Carlo (GCMC) simulations based on a specific force field describing the interactions between the guest molecules and the Ga sites supported and confirmed the considerably higher affinity of the Ga-soc-MOF for C2+ (as exemplified by n-C4H10) than for CH4. The careful selection of an appropriate metal for the trinuclear inorganic molecular building block (MBB), i. e., a Ga metal center, imbues the soc

Péndulos astronómicos y cronómetros marinos de la armada: el observatorio de San Fernando y los antecedentes del patrón nacional de tiempo (1753-1957

Directory of Open Access Journals (Sweden)

González González, Francisco José

1998-06-01

Full Text Available This article is a brief review on the precision clocks in use by the Spanish Navy during the XVIII, XIX and XX centuries. It deals with the introduction in Spain of marine chronometers needed for the application of the new techniques of astronomical navigation and also, with the evolution of the methods for time keeping and determination by astronomical pendulum clocks. Both facts placed the Navy and its Observatory in a good starting position for future activity in the field of the scientific study of time in our country.

Este artículo presenta un breve estudio sobre los relojes de precisión usados por la Armada española durante los siglos XVIII, XIX y XX. Se trata, por una parte, sobre la introducción en España de los cronómetros marinos, necesarios para la aplicación de las nuevas técnicas de navegación astronómica. Se estudia, además, la evolución del sistema de determinación y conservación de la hora mediante péndulos astronómicos, origen del servicio horario del Observatorio de San Femando. Ambas vertientes sitúan a la Marina, y a su Observatorio, en un lugar preferente en los trabajos relacionados con el cómputo científico del tiempo en nuestro país.

System on chip (SoC) microcontrollers (μC) as digitisers for ion beam analysis (IBA) instruments

Energy Technology Data Exchange (ETDEWEB)

Whitlow, Harry J., E-mail: harry.j@whitlow.se

2016-09-15

Data digitisation of the analogue signals from detectors to digital data is an essential process in ion beam analysis (IBA). The low-cost, easy availability and development environments that have a low learning threshold makes system-on-chip (SoC) microcontrollers (μC) attractive for this task. These μC combine, on one die, analogue and digital inputs and outputs with serial USB interfaces, which opens up simple implementation of tailor-made interfaces for specific IBA measurement systems. We have investigated the design and performance limitations based on development of three different digitisation interfaces for IBA. These were a two-channel nuclear instrumentation module (NIM) ADC event mode interface (EMI) for a high-resolution magnetic RBS spectrometer, a simple headless-multi-channel analyser (MCA) and a combined dual channel headless MCA and EMI. It is shown that SoC μC based interfaces for digitisation of analogue spectroscopy pulses in IBA systems can be implemented for material costs less than 100 €. The performance of the SoC devices for many IBA applications is close to what can be achieved with state-of-the-art instruments. The simple pulse spectroscopy interface circuit and software are included in the auxiliary archive.

Soil organic carbon (SOC) accumulation in rice paddies under long-term agro-ecosystem experiments in southern China - VI. Changes in microbial community structure and respiratory activity

Science.gov (United States)

Liu, D.; Liu, X.; Liu, Y.; Li, L.; Pan, G.; Crowley, D.; Tippkötter, R.

2011-02-01

Biological stabilization within accumulated soil organic carbon (SOC) has not been well understood, while its role in physical and chemical protection as well as of chemical recalcitrance had been addressed in Chinese rice paddies. In this study, topsoil samples were collected and respiratory activity measured in situ following rice harvest under different fertilization treatments of three long-term experimental sites across southern China in 2009. The SOC contents, microbial biomass carbon (SMBC) and nitrogen (SMBN) were analysed using chemical digestion and microbial community structure assessment via clony dilute plate counting methods. While SOC contents were consistently higher under compound chemical fertilization (Comp-Fert) or combined organic and inorganic fertilization (Comb-Fert) compared to N fertilization only (N-Fert), there was significantly higher fungal-bacterial ratio under Comb-Fert than under N-Fert and Comp-Fert. When subtracting the background effect under no fertilization treatment (Non-Fert), the increase both in SMBC and SMBN under fertilization treatment was found very significantly correlated to the increase in SOC over controls across the sites. Also, the ratio of culturable fungal to bacterial population numbers (F/B ratio) was well correlated with soil organic carbon contents in all samples across the sites studied. SOC accumulation favoured a build-up the microbial community with increasing fungal dominance in the rice paddies under fertilization treatments. While soil respiration rates were high under Comb-Fert as a result of enhanced microbial community build-up, the specific soil respiratory activity based on microbial biomass carbon was found in a significantly negatively correlation with the SOC contents for overall samples. Thus, a fungal-dominated microbial community seemed to slow SOC turnover, thereby favouring SOC accumulation under Comp-Fert or under Comb-Fert in the rice paddies. Therefore, the biological stabilization

Assessing SOC labile fractions through respiration test, density-size fractionation and thermal analysis - A comparison of methods

Science.gov (United States)

Soucemarianadin, Laure; Cécillon, Lauric; Chenu, Claire; Baudin, François; Nicolas, Manuel; Savignac, Florence; Barré, Pierre

2017-04-01

Soil organic matter (SOM) is the biggest terrestrial carbon reservoir, storing 3 to 4 times more carbon than the atmosphere. However, despite its major importance for climate regulation SOM dynamics remains insufficiently understood. For instance, there is still no widely accepted method to assess SOM lability. Soil respiration tests and particulate organic matter (POM) obtained by different fractionation schemes have been used for decades and are now considered as classical estimates of very labile and labile soil organic carbon (SOC), respectively. But the pertinence of these methods to characterize SOM turnover can be questioned. Moreover, they are very time-consuming and their reproducibility might be an issue. Alternate ways of determining the labile SOC component are thus well-needed. Thermal analyses have been used to characterize SOM among which Rock-Eval 6 (RE6) analysis of soil has shown promising results in the determination of SOM biogeochemical stability (Gregorich et al., 2015; Barré et al., 2016). Using a large set of samples of French forest soils representing contrasted pedoclimatic conditions, including deep samples (up to 1 m depth), we compared different techniques used for SOM lability assessment. We explored whether results from soil respiration test (10-week laboratory incubations), SOM size-density fractionation and RE6 thermal analysis were comparable and how they were correlated. A set of 222 (respiration test and RE6), 103 (SOM fractionation and RE6) and 93 (respiration test, SOM fractionation and RE6) forest soils samples were respectively analyzed and compared. The comparison of the three methods (n = 93) using a principal component analysis separated samples from the surface (0-10 cm) and deep (40-80 cm) layers, highlighting a clear effect of depth on the short-term persistence of SOC. A correlation analysis demonstrated that, for these samples, the two classical methods of labile SOC determination (respiration and SOM fractionation

E-CMIRC - towards a model for the integration of services between SOCs and CSIRTs

CSIR Research Space (South Africa)

Jacobs, P

2015-07-01

Full Text Available , including governments. While the focus of a SOC is on the monitoring of technical security controls and critical assets, and the response to attacks and threats, CSIRTs’ main focus is on response and incident management. One postulation is that a CSIRT...

An Overview and Comparison of Online Implementable SOC Estimation Methods for Lithium-ion Battery

DEFF Research Database (Denmark)

Meng, Jinhao; Ricco, Mattia; Luo, Guangzhao

2018-01-01

With the popularity of Electrical Vehicles (EVs), Lithium-ion battery industry is developing rapidly. To ensure the battery safe usage and to reduce its average lifecycle cost, an accurate State of Charge (SOC) tracking algorithms for real-time implementation are required for different applications...

SOCS3 Expression Correlates with Severity of Inflammation, Expression of Proinflammatory Cytokines, and Activation of STAT3 and p38 MAPK in LPS-Induced Inflammation In Vivo

Directory of Open Access Journals (Sweden)

João Antônio Chaves de Souza

2013-01-01

Full Text Available SOCS3 is an inducible endogenous negative regulator of JAK/STAT pathway, which is relevant in inflammatory conditions. We used a model of LPS-induced periodontal disease in rats to correlate SOCS3 expression with the inflammatory status. In vitro we used a murine macrophage cell line to assess the physical interaction between SOCS3 and STAT3 by coimmunoprecipitation. 30 ug of LPS from Escherichia coli were injected in the gingival tissues on the palatal aspect of first molars of the animals 3x/week for up to 4 weeks. Control animals were injected with the vehicle (PBS. The rats were sacrificed at 7, 15, and 30 days. Inflammation and gene expression were assessed by stereometric analysis, immunohistochemistry, RT-qPCR, and western blot. LPS injections increased inflammation, paralleled by an upregulation of SOCS3, of the proinflammatory cytokines IL-1β, IL-6, and TNF-α and increased phosphorylation of STAT3 and p38 MAPK. SOCS3 expression accompanied the severity of inflammation and the expression of proinflammatory cytokines, as well as the activation status of STAT3 and p38 MAPK. LPS stimulation in a macrophage cell line in vitro induced transient STAT3 activation, which was inversely correlated with a dynamic physical interaction with SOCS3, suggesting that this may be a mechanism for SOCS3 regulatory function.

Functional network analysis of genes differentially expressed during xylogenesis in soc1ful woody Arabidopsis plants.

Science.gov (United States)

Davin, Nicolas; Edger, Patrick P; Hefer, Charles A; Mizrachi, Eshchar; Schuetz, Mathias; Smets, Erik; Myburg, Alexander A; Douglas, Carl J; Schranz, Michael E; Lens, Frederic

2016-06-01

Many plant genes are known to be involved in the development of cambium and wood, but how the expression and functional interaction of these genes determine the unique biology of wood remains largely unknown. We used the soc1ful loss of function mutant - the woodiest genotype known in the otherwise herbaceous model plant Arabidopsis - to investigate the expression and interactions of genes involved in secondary growth (wood formation). Detailed anatomical observations of the stem in combination with mRNA sequencing were used to assess transcriptome remodeling during xylogenesis in wild-type and woody soc1ful plants. To interpret the transcriptome changes, we constructed functional gene association networks of differentially expressed genes using the STRING database. This analysis revealed functionally enriched gene association hubs that are differentially expressed in herbaceous and woody tissues. In particular, we observed the differential expression of genes related to mechanical stress and jasmonate biosynthesis/signaling during wood formation in soc1ful plants that may be an effect of greater tension within woody tissues. Our results suggest that habit shifts from herbaceous to woody life forms observed in many angiosperm lineages could have evolved convergently by genetic changes that modulate the gene expression and interaction network, and thereby redeploy the conserved wood developmental program. © 2016 The Authors. The Plant Journal published by Society for Experimental Biology and John Wiley & Sons Ltd.

Coupling the nongravitational forces and modified Newton dynamics for cometary orbits

Science.gov (United States)

Maquet, Lucie; Pierret, Frédéric

2015-04-01

In recent work [L. Blanchet and J. Novak, Mon. Not. R. Astron. Soc. 412, 2530 (2011); L. Blanchet and J. Novak, Testing MOND in the Solar System (2011); and M. Milgrom, Mon. Not. R. Astron. Soc. 399, 474 (2009)], the authors showed that modified Newton dynamics (MOND) has a non-negligible secular perturbation effect on planets with large semimajor axes (gaseous planets) in the Solar System. Some comets also have a very eccentric orbit with a large semimajor axis (Halley family comets) going far away from the Sun (more than 15 AU) in a low acceleration regime where they would be subject to MOND perturbation. They also approach the Sun very closely (less than 3 AU) and are affected by the sublimation of ices from their nucleus, triggering so-called nongravitational forces. The main goal of this paper is to investigate the effect of MOND perturbation on three comets with various orbital elements (2 P /Encke , 1 P /Halley and 153 P /Ikeya-Zhang ) and then compare it to the nongravitational perturbations. It is motivated by the fact that when fitting an outgassing model for a comet, we have to take into account all of the small perturbing effects to avoid absorbing these effects into the nongravitational parameters. Otherwise, we could derive a completely wrong estimation of the outgassing. For this work, we use six different forms of MOND functions and compute the secular variations of the orbital elements due to MOND and nongravitational perturbations. We show that, for comets with large semimajor axis, the MONDian effects are not negligible compared to the nongravitational perturbations.

Universal interface on Zynq"® SoC with CAN, RS-232, Ethernet and AXI GPIO for instrumentation & control

International Nuclear Information System (INIS)

Kumar, Abhijeet; Rajpal, Rachana; Pujara, Harshad; Mandaliya, Hitesh; Edappala, Praveenalal

2016-01-01

Highlights: • We have designed Universal Interface on Zynq"® SoC with CAN, RS-232, Ethernet and AXI GPIO for Instrumentation & Control. This project is based on Zynq"®-7000 family xc7z020clg484-1 chip. • We explored the full design flow starting from the hardware development in Vivado to software development in SDK using APIs in C language and then interfacing the host application developed in LabVIEW. • We also explored how to make custom IP with AXI bus interface in Vivado. • Useful for those who wants to make custom hardware on Zynq"® SoC. - Abstract: This paper describes an application developed on the latest Zynq"®-7000 All Programmable SoC (AP SoC) [1] devices which integrate the software programmability of an ARM"®-based processor with the hardware programmability of an FPGA, on a single device. In this paper we have implemented application which uses various interfaces like CAN, RS-232, Ethernet and AXI GPIO, so that our host application running on PC in LabVIEW can communicates with any hardware which has at least any one of the available interface. Zynq-7000 All Programmable SoCs (System On Chip) infuse customizable intelligence into today’s embedded systems to suit your unique application requirements. This family of FPGA is meant for high end application because it has huge resources on single chip. It offers you to make your own custom hardware IP, in fact we have made our custom IP called myIP in our design. The beauty of this chip is that it can write drivers for your custom IP which has AXI bus layer attached. After exporting the hardware information to the Software Development Kit (SDK), the tool is able to write drivers for your custom IP. This simplifies your development to a great extent. In a way this application provides the universal interfacing option to user. User can also write the digital data on the GPIO (General Purpose Input Output) through LabVIEW Test application GUI. This project can be used for remote control and

Strong lensing probability in TeVeS (tensor–vector–scalar) theory

International Nuclear Information System (INIS)

Chen Daming

2008-01-01

We recalculate the strong lensing probability as a function of the image separation in TeVeS (tensor–vector–scalar) cosmology, which is a relativistic version of MOND (MOdified Newtonian Dynamics). The lens is modeled by the Hernquist profile. We assume an open cosmology with Ω b = 0.04 and Ω Λ = 0.5 and three different kinds of interpolating functions. Two different galaxy stellar mass functions (GSMF) are adopted: PHJ (Panter, Heavens and Jimenez 2004 Mon. Not. R. Astron. Soc. 355 764) determined from SDSS data release 1 and Fontana (Fontana et al 2006 Astron. Astrophys. 459 745) from GOODS-MUSIC catalog. We compare our results with both the predicted probabilities for lenses from singular isothermal sphere galaxy halos in LCDM (Lambda cold dark matter) with a Schechter-fit velocity function, and the observational results for the well defined combined sample of the Cosmic Lens All-Sky Survey (CLASS) and Jodrell Bank/Very Large Array Astrometric Survey (JVAS). It turns out that the interpolating function μ(x) = x/(1+x) combined with Fontana GSMF matches the results from CLASS/JVAS quite well

Transient receptor potential ion channel Trpm7 regulates exocrine pancreatic epithelial proliferation by Mg2+-sensitive Socs3a signaling in development and cancer

Directory of Open Access Journals (Sweden)

Nelson S. Yee

2011-03-01

Genetic analysis of pancreatic development has provided new insights into the mechanisms underlying the formation of exocrine pancreatic neoplasia. Zebrafish sweetbread (swd mutants develop hypoplastic acini and dysmorphic ducts in the exocrine pancreas, with impeded progression of cell division cycle and of epithelial growth. Positional cloning and allelic complementation have revealed that the swd mutations affect the transient receptor potential melastatin-subfamily member 7 (trpm7 gene, which encodes a divalent cation-permeable channel with kinase activity. Supplementary Mg2+ partially rescued the exocrine pancreatic defects of the trpm7 mutants by improving cell-cycle progression and growth and repressing the suppressor of cytokine signaling 3a (socs3a gene. The role of Socs3a in Trpm7-mediated signaling is supported by the findings that socs3a mRNA level is elevated in the trpm7 mutants, and antisense inhibition of socs3a expression improved their exocrine pancreatic growth. TRPM7 is generally overexpressed in human pancreatic adenocarcinoma. TRPM7-deficient cells are impaired in proliferation and arrested in the G0-G1 phases of the cell division cycle. Supplementary Mg2+ rescued the proliferative defect of the TRPM7-deficient cells. Results of this study indicate that Trpm7 regulates exocrine pancreatic development via the Mg2+-sensitive Socs3a pathway, and suggest that aberrant TRPM7-mediated signaling contributes to pancreatic carcinogenesis.

SoC Design Approach Using Convertibility Verification

Directory of Open Access Journals (Sweden)

Basu Samik

2008-01-01

Full Text Available Abstract Compositional design of systems on chip from preverified components helps to achieve shorter design cycles and time to market. However, the design process is affected by the issue of protocol mismatches, where two components fail to communicate with each other due to protocol differences. Convertibility verification, which involves the automatic generation of a converter to facilitate communication between two mismatched components, is a collection of techniques to address protocol mismatches. We present an approach to convertibility verification using module checking. We use Kripke structures to represent protocols and the temporal logic to describe desired system behavior. A tableau-based converter generation algorithm is presented which is shown to be sound and complete. We have developed a prototype implementation of the proposed algorithm and have used it to verify that it can handle many classical protocol mismatch problems along with SoC problems. The initial idea for -based convertibility verification was presented at SLA++P '07 as presented in the work by Roopak Sinha et al. 2008.

Measurement of the complete core plasma flow across the LOC-SOC transition at ASDEX Upgrade

Science.gov (United States)

Lebschy, A.; McDermott, R. M.; Angioni, C.; Geiger, B.; Prisiazhniuk, D.; Cavedon, M.; Conway, G. D.; Dux, R.; Dunne, M. G.; Kappatou, A.; Pütterich, T.; Stroth, U.; Viezzer, E.; the ASDEX Upgrade Team

2018-02-01

A newly installed core charge exchange recombination spectroscopy (CXRS) diagnostic at ASDEX Upgrade (AUG) enables the evaluation of the core poloidal rotation (upol ) through the inboard-outboard asymmetry of the toroidal rotation with an accuracy of 0.5 to 1 km s-1 . Using this technique, the total plasma flow has been measured in Ohmic L-mode plasmas across the transition from the linear to saturated ohmic confinement (LOC-SOC) regimes. The core poloidal rotation of the plasma around mid-radius is found to be always in the ion diamagnetic direction, in disagreement with neoclassical (NC) predictions. The edge rotation is found to be electron-directed and consistent with NC codes. This measurement provides as well the missing ingredient to evaluate the core E×B velocity (uE×B ) from data only, which can then be compared to measurements of the perpendicular velocity of the turbulent fluctuations (u\\perp ) to gain information on the turbulent phase velocity (vph ). The non neoclassical upol from CXRS leads to good agreement between uE×B and u\\perp indicating that vph is small and at similar values as found with gyrokinetic simulations. Moreover, the data shows a shift of vph in the ion-diamagnetic direction at the edge after the transition from LOC to SOC consistent with a change in the dominant turbulence regime. The upgrade of the core CXRS system provides as well a deeper insight into the intrinsic rotation. This paper shows that the reversal of the core toroidal rotation occurs clearly after the LOC-SOC transition and concomitant with the peaking of the electron density.

Universal interface on Zynq{sup ®} SoC with CAN, RS-232, Ethernet and AXI GPIO for instrumentation & control

Energy Technology Data Exchange (ETDEWEB)

Kumar, Abhijeet, E-mail: akumar@ipr.res.in; Rajpal, Rachana; Pujara, Harshad; Mandaliya, Hitesh; Edappala, Praveenalal

2016-11-15

Highlights: • We have designed Universal Interface on Zynq{sup ®} SoC with CAN, RS-232, Ethernet and AXI GPIO for Instrumentation & Control. This project is based on Zynq{sup ®}-7000 family xc7z020clg484-1 chip. • We explored the full design flow starting from the hardware development in Vivado to software development in SDK using APIs in C language and then interfacing the host application developed in LabVIEW. • We also explored how to make custom IP with AXI bus interface in Vivado. • Useful for those who wants to make custom hardware on Zynq{sup ®} SoC. - Abstract: This paper describes an application developed on the latest Zynq{sup ®}-7000 All Programmable SoC (AP SoC) [1] devices which integrate the software programmability of an ARM{sup ®}-based processor with the hardware programmability of an FPGA, on a single device. In this paper we have implemented application which uses various interfaces like CAN, RS-232, Ethernet and AXI GPIO, so that our host application running on PC in LabVIEW can communicates with any hardware which has at least any one of the available interface. Zynq-7000 All Programmable SoCs (System On Chip) infuse customizable intelligence into today’s embedded systems to suit your unique application requirements. This family of FPGA is meant for high end application because it has huge resources on single chip. It offers you to make your own custom hardware IP, in fact we have made our custom IP called myIP in our design. The beauty of this chip is that it can write drivers for your custom IP which has AXI bus layer attached. After exporting the hardware information to the Software Development Kit (SDK), the tool is able to write drivers for your custom IP. This simplifies your development to a great extent. In a way this application provides the universal interfacing option to user. User can also write the digital data on the GPIO (General Purpose Input Output) through LabVIEW Test application GUI. This project can be used

Use of 'sense of coherence (SOC)' scale to measure resilience in Eritrea: interrogating both the data and the scale.

Science.gov (United States)

Almedom, Astier M; Tesfamichael, Berhe; Saeed Mohammed, Zein; Mascie-Taylor, C G N; Alemu, Zemui

2007-01-01

An adapted 'sense of coherence' scale short form (SOC-13) was administered in nine languages of Eritrea with a total of 265 participants (162 women and 103 men) in order to assess 'resilience' in quantitative terms. Statistical analysis yielded significant differences in SOC scores between the displaced and non-displaced: mean=54.84 (SD=6.48) in internally displaced person (IDP) camps, compared with mean=48.94 (SD=11.99) in urban and rural settlements (t=3.831, purban (non-displaced) residents. Those in rural but traditionally mobile (pastoralist or transhumant) communities scored more or less the same as the urban non-displaced - i.e. significantly higher than those in IDP camps (purban and pastoralist/transhumant groups are similar, while women in IDP camps are lower scoring (RR=0.268, p<0.001), Hamboka women being worst affected due to their experience of serial displacement. These findings are interpreted and discussed in the light of qualitative information gleaned from the study participants' interrogation of the content of the SOC scale; and in the wider context of historical, socio-political and cultural characteristics of Eritrea. The study's implications for humanitarian and public health policy are considered.

Energy efficient HPC on embedded SoCs : optimization techniques for mali GPU

OpenAIRE

Grasso, Ivan; Radojkovic, Petar; Rajovic, Nikola; Gelado Fernandez, Isaac; Ramírez Bellido, Alejandro

2014-01-01

A lot of effort from academia and industry has been invested in exploring the suitability of low-power embedded technologies for HPC. Although state-of-the-art embedded systems-on-chip (SoCs) inherently contain GPUs that could be used for HPC, their performance and energy capabilities have never been evaluated. Two reasons contribute to the above. Primarily, embedded GPUs until now, have not supported 64-bit floating point arithmetic - a requirement for HPC. Secondly, embedded GPUs did not pr...

An improved PNGV modeling and SOC estimation for lithium iron phosphate batteries

Science.gov (United States)

Li, Peng

2017-11-01

Because lithium iron phosphate battery has many advantages, it has been used more and more widely in the field of electric vehicle. The lithium iron phosphate battery, presents the improved PNGV model, and the batteries charge discharge characteristics and pulse charge discharge experiments, identification of parameters of the battery model by interpolation and least square fitting method, to achieve a more accurate modeling of lithium iron phosphate battery, and the extended Calman filter algorithm (EKF) is completed state nuclear power battery (SOC) estimate.

Approche complète de développement des IPs pour les SoCs A ...

African Journals Online (AJOL)

CoFluent and Quartus II tools have helped us to get the different models. ... Key words : IPs – SoC - Design and Reuse – UML – System C ... nouvelles techniques de conception doivent- .... obtenir un prototype fabriqué et testé. ..... Information Technology and Control, ... A new logic circuit design methodology with UMLl.

Early secreted antigen ESAT-6 of Mycobacterium Tuberculosis promotes apoptosis of macrophages via targeting the microRNA155-SOCS1 interaction.

Science.gov (United States)

Yang, Shaojun; Li, Fake; Jia, Shuangrong; Zhang, Kejun; Jiang, Wenbing; Shang, Ya; Chang, Kai; Deng, Shaoli; Chen, Ming

2015-01-01

The early secreted antigenic target 6-kDa protein (ESAT-6) of Mycobacterium tuberculosis (Mtb) not only acts as a key player for virulence but also exhibits a strong immunotherapeutic potential against Mtb. However, little is known about the molecular basis for its potential in immunotherapy. The present study was designed to unravel the role of miRNA-155 in ESAT-6-mediated enhancement of host immunity and apoptosis in macrophages. Lentivirus-mediated miR-155 sponge and miR-155 and SOCS1 overexpression vectors were developed in macrophages. TLR2- or p65-specific siRNA knockdown was employed to silence TLR2 or p65. Quantitative polymerase chain reaction and western blotting analyses were performed to determine mRNA and protein expression levels, respectively. Macrophage apoptosis was analyzed by flow cytometry. ESAT-6 significantly increased miR-155 expression, which was dependent on TLR2/NF-κB activation in macrophages. Induced expression of miRNA-155 was required for the ESAT-6-mediated protective immune response and macrophage apoptosis. ESAT-6 promoted macrophage apoptosis by targeting the miR-155-SOCS1 pathway. The differential expression levels of TLR2, BIC, and SOCS1 were involved in regulating the immune response in human peripheral blood mononuclear cells of patients with active tuberculosis (TB) and latent TB (LTB). ESAT-6 promotes apoptosis of macrophages via targeting the miRNA155-SOCS1 interaction. © 2015 S. Karger AG, Basel.

Early Secreted Antigen ESAT-6 of Mycobacterium Tuberculosis Promotes Apoptosis of Macrophages via Targeting the MicroRNA155-SOCS1 Interaction

Directory of Open Access Journals (Sweden)

Shaojun Yang

2015-02-01

Full Text Available Background: The early secreted antigenic target 6-kDa protein (ESAT-6 of Mycobacterium tuberculosis (Mtb not only acts as a key player for virulence but also exhibits a strong immunotherapeutic potential against Mtb. However, little is known about the molecular basis for its potential in immunotherapy. The present study was designed to unravel the role of miRNA-155 in ESAT-6-mediated enhancement of host immunity and apoptosis in macrophages. Methods: Lentivirus-mediated miR-155 sponge and miR-155 and SOCS1 overexpression vectors were developed in macrophages. TLR2- or p65-specific siRNA knockdown was employed to silence TLR2 or p65. Quantitative polymerase chain reaction and western blotting analyses were performed to determine mRNA and protein expression levels, respectively. Macrophage apoptosis was analyzed by flow cytometry. Results: ESAT-6 significantly increased miR-155 expression, which was dependent on TLR2/NF-κB activation in macrophages. Induced expression of miRNA-155 was required for the ESAT-6-mediated protective immune response and macrophage apoptosis. ESAT-6 promoted macrophage apoptosis by targeting the miR-155-SOCS1 pathway. The differential expression levels of TLR2, BIC, and SOCS1 were involved in regulating the immune response in human peripheral blood mononuclear cells of patients with active tuberculosis (TB and latent TB (LTB. Conclusion: ESAT-6 promotes apoptosis of macrophages via targeting the miRNA155-SOCS1 interaction.

Clock generators for SOC processors circuits and architectures

CERN Document Server

Fahim, Amr

2004-01-01

This book explores the design of fully-integrated frequency synthesizers suitable for system-on-a-chip (SOC) processors. The text takes a more global design perspective in jointly examining the design space at the circuit level as well as at the architectural level. The comprehensive coverage includes summary chapters on circuit theory as well as feedback control theory relevant to the operation of phase locked loops (PLLs). On the circuit level, the discussion includes low-voltage analog design in deep submicron digital CMOS processes, effects of supply noise, substrate noise, as well device noise. On the architectural level, the discussion includes PLL analysis using continuous-time as well as discrete-time models, linear and nonlinear effects of PLL performance, and detailed analysis of locking behavior. The book provides numerous real world applications, as well as practical rules-of-thumb for modern designers to use at the system, architectural, as well as the circuit level.

Angiotensin II (AngII) induces the expression of suppressor of cytokine signaling (SOCS)-3 in rat hypothalamus - a mechanism for desensitization of AngII signaling.

Science.gov (United States)

Torsoni, Márcio A; Carvalheira, José B; Calegari, Vivian C; Bezerra, Rosangela M N; Saad, Mário J A; Gontijo, José A; Velloso, Lício A

2004-04-01

Angiotensin II exerts a potent dypsogenic stimulus on the hypothalamus, which contributes to its centrally mediated participation in the control of water balance and blood pressure. Repetitive intracerebroventricular (i.c.v.) injections of angiotensin II lead to a loss of effect characterized as physiological desensitization to the peptide's action. In the present study, we demonstrate that angiotensin II induces the expression of suppressor of cytokine signaling (SOCS)-3 via angiotensin receptor 1 (AT1) and JAK-2, mostly located at the median preoptic lateral and anterodorsal preoptic nuclei. SOCS-3 produces an inhibitory effect upon the signal transduction pathways of several cytokines and hormones that employ members of the JAK/STAT families as intermediaries. The partial inhibition of SOCS-3 translation by antisense oligonucleotide was sufficient to significantly reduce the refractoriness of repetitive i.c.v. angiotensin II injections, as evaluated by water ingestion. Thus, by acting through AT1 on the hypothalamus, angiotensin II induces the expression of SOCS-3 which, in turn, blocks further activation of the pathway and consequently leads to desensitization to angiotensin II stimuli concerning its dypsogenic effect.

An ESL Approach for Energy Consumption Analysis of Cache Memories in SoC Platforms

Directory of Open Access Journals (Sweden)

Abel G. Silva-Filho

2011-01-01

Full Text Available The design of complex circuits as SoCs presents two great challenges to designers. One is the speeding up of system functionality modeling and the second is the implementation of the system in an architecture that meets performance and power consumption requirements. Thus, developing new high-level specification mechanisms for the reduction of the design effort with automatic architecture exploration is a necessity. This paper proposes an Electronic-System-Level (ESL approach for system modeling and cache energy consumption analysis of SoCs called PCacheEnergyAnalyzer. It uses as entry a high-level UML-2.0 profile model of the system and it generates a simulation model of a multicore platform that can be analyzed for cache tuning. PCacheEnergyAnalyzer performs static/dynamic energy consumption analysis of caches on platforms that may have different processors. Architecture exploration is achieved by letting designers choose different processors for platform generation and different mechanisms for cache optimization. PCacheEnergyAnalyzer has been validated with several applications of Mibench, Mediabench, and PowerStone benchmarks, and results show that it provides analysis with reduced simulation effort.

Variaciones seculares de período en las RR Lyrae de ω~Centauri

Science.gov (United States)

Marraco, H. G.; Milesi, G. E.

Utilizando 689 observaciones de 35 estrellas RR Lyrae del cúmulo globular ω Centauri hemos obtenido nuevas determinaciones de sus períodos y sus correspondientes variaciones seculares. Las observaciones fueron obtenidas de la literatura con la excepción de un grupo 66 determinaciones que se presentan por vez primera aquí. Utilizando el parámetro testigo σ descripto en Marraco & Muzzio (Publ. Astron. Soc. Pacific 92, 700, 1980), hemos realizado un ajuste bidimensional en P y β (donde β es la variación secular del período). Con este fin la totalidad de las 689 observaciones fueron llevadas a un sistema fotométrico común. Para esto se realizó un cuidadoso análisis de los numerosos errores en la identificación de las estrellas de las series de comparación. Los resultados de los ajustes bidimensionales fueron analizados utilizando técnicas de procesamiento de imágenes. Con este fin el parámetro de ajuste σ fue representado como función de P y β. En las imágenes resultantes se buscaron los mínimos y al menor de ellos se lo aceptó como período instantáneo verdadero y su variación secular β. La determinación precisa de cada parámetro se realizó mediante ajuste de gaussianas y se determinaron sus errores. A modo de ejemplo la variable #8 fue analizada en una matriz de 501 × 501 elementos representando el parámetro σ para valores comprendidos entre 0,521034 son P = 0,5212859±0,0000001 días y β 14,012±,010×10-10 días/día respectivamente. Con estos valores el parámetro testigo resulta σ= 0,127 . Si no se tiene en cuenta la variación secular del período y se busca aquél de mejor ajuste para β = 0, se obtiene P = 0,5212960 días, pero entonces el parámetro de ajuste resulta tan alto como σ = 0,23 .

Insulin resistance, adipokine profile and hepatic expression of SOCS-3 gene in chronic hepatitis C.

Science.gov (United States)

Wójcik, Kamila; Jabłonowska, Elżbieta; Omulecka, Aleksandra; Piekarska, Anna

2014-08-14

To analyze adipokine concentrations, insulin resistance and hepatic expression of suppressor of cytokine signaling 3 (SOCS-3) in patients with chronic hepatitis C genotype 1 with normal body weight, glucose and lipid profile. The study group consisted of 31 patients with chronic hepatitis C and 9 healthy subjects. Total levels of adiponectin, leptin, resistin, visfatin, omentin, osteopontin and insulin were measured using an ELISA kit. The hepatic expression of SOCS-3 was determined by the use of the reverse transcription polymerase chain reaction method. Homeostasis model assessment for insulin resistance (HOMA-IR) values were significantly higher in hepatitis C virus (HCV) infected patients without metabolic disorders compared to healthy controls (2.24 vs 0.59, P = 0.0003). Hepatic steatosis was observed in 32.2% of patients with HCV infection and was found in patients with increased HOMA-IR index (2.81 vs 1.99, P = 0.05) and reduced adiponectin level (5.96 vs 8.37, P = 0.04). Inflammatory activity (G ≥ 2) was related to increased osteopontin concentration (34.04 vs 23.35, P = 0.03). Advanced liver fibrosis (S ≥ 2) was associated with increased levels of omentin and osteopontin (436.94 vs 360.09, P = 0.03 and 32.84 vs 20.29, P = 0.03) and reduced resistin concentration (1.40 vs 1.74, P = 0.047). No correlations were reported between adipokine profile, HOMA-IR values and hepatic expression of the SOCS-3 gene. We speculated that no relationship between adipokines and HOMA-IR values may indicate that HCV can induce insulin resistance itself. Some adipokines appear to be biochemical markers of steatosis, inflammation and fibrosis in patients with chronic HCV infection. © 2014 Baishideng Publishing Group Inc. All rights reserved.

Testing cosmology from fundamental considerations: Is the Friedmann universe intrinsically flat

Science.gov (United States)

Mitra, Abhas

2014-02-01

Recently Melia and Shevchuk (Mon Not R Astron Soc 419:2579,2012) (MS) have proposed the so-called cosmology where the "Gravitational Horizon" of the universe is equal to the distance travelled by light since "Big Bang". Here we would like to see whether the basic claim is correct or not because MS have not given any cogent derivation for the same. Essentially we will compare the twin expressions for the Einstein energy momentum complex (EMC) of the Friedmann universe obtained by using an appropriate superpotential and also by a direct method. To enable a meaningful comparison of the twin expressions, both are computed by using the same quasi-Cartesian coordinates. We however do not claim that Einstein EMC is superior to many other routes of defining EM of a self-gravitating system. In fact, for static isolated spherical syatems, the idea of a coordinate independent field energy of Lynden-Bell and Katz (Mon Not R Astron Soc 213:21, 1985) might be quite physically significant. Yet, here, we use Einstein EMC because (i) our system is non-static and not isolated one (ii) our primary aim is not find any absolute value of EM, and, finally, (iii) only Einstein pseudo-tensor offers equivalent twin expressions for EM which one can be equated irrespective of any physical significance. Following such comparison of equivalent twin expressions of Einstein energy, we find an exact proof as to why Friedmann universe must be spatially flat even though, mathematically one can conceive of curved spaces in any dimension. Additionally, it follows that, apparently, the scale factor as insisted by proposition. Nonetheless, because of close similarity of this form, , with the (vacuum) Milne metric, and also because of implied unphysical equation of state, cosmology is unlikely to represent the physical universe.

Variations of Synchrotron Radio Emissions from Jupiter's Inner Radiation Belt

Science.gov (United States)

Lou, Y.-Q.

2017-09-01

Variations of Synchrotron Radio Emissions from Jupiter's Inner Radiation Belt Yu-Qing Lou* Physics Department, Tsinghua Centre for Astrophysics (THCA), Tsinghua-National Astronomical Observatories of China (NAOC) joint Research Centre for Astrophysics, Tsinghua University, Beijing 100084, China We describe the basic phenommenology of quasi-periodic 40 minute (QP-40) polar burst activities of Jupiter and their close correlation with the solar wind speed variations at the Jovian magnetosphere. Physically, relativistic electrons of QP-40 bursts most likely come from the circumpolar regions of the inner radiation belt (IRB) which gives off intense synchroton radio emissions in a wide wavelength range. Such relativistic electron bursts also give rise to beamed low-frequency radio bursts along polar magnetic field lines with distinct polarizations from Jupiter's two polar regions. Jovian aurora activities are expected to be also affected by such QP-40 burst activities. We present evidence of short-term (typical timescales shorter than an hour) variabilities of the IRB at 6cm wavelength and describe recent joint radio telescope observation campaign to monitor Jupiter in coordination with JUNO spacecraft. Except for low-frequency polarization features, we anticipate JUNO to detect QP-40 activities from both polar regions during the arrival of high-speed solar wind with intermittency. References 1. Y.-Q. Lou, The Astrophysical Journal, 548, 460 (2001). 2. Y.-Q. Lou, and C. Zheng, Mon. Not. Roy. Astron. Soc. Letters, 344, L1 (2003). 3. Y.-Q. Lou, H. G. Song, Y.Y. Liu, and M. Yang, Mon. Not. Roy. Astron. Soc. Letters, 421, L62 (2012). 4. Y.-Q. Lou, Geophysical Research Letters, 23, 609 (1996). 5. Y.-Q. Lou, Journal of Geophysical Research, 99, 14747 (1994). 6. G. R. Gladstone, et al., Nature, 415, 1000 (2002).

A Reappraising of Cosmography: the Interface Between Astronomical and Geographic Studies. (Breton Title: Releitura do Conceito de Cosmografia: a Interface Entre os Estudos Astronômicos e Geográficos.) Una Relectura del Concepto de Cosmografía: la Interfase Entre los Estudios Astronómicos y Geográficos

Science.gov (United States)

Azevedo Sobreira, Paulo Henrique

2012-12-01

The concept of "Cosmography" is in disuse since the 80s of the last century, but the astronomical themes previously discussed in the school subjects of Geography and Cosmography remain in current textbooks. The use of term "Cosmography" was rescued in this research, and the study of its re-signification prompted the appearance of the term Geographic Cosmography. The Geographic Cosmography is a field of studies of the Geography, whose set of knowledge and skills is predominantly scholar. It studies the interface between terrestrial and celestial knowledge, and assigns a geographic significance to them. It examines human and natural relationships with Sidereal Space and its consequences for society and nature. O conceito de "Cosmografia" está em desuso desde os anos 80 do século XX, mas os temas astronômicos anteriormente abordados nas disciplinas escolares de Cosmografia e de Geografia permanecem nos atuais livros didáticos. O uso do termo "Cosmografia" foi resgatado nesta pesquisa e o estudo de sua ressignificação proporcionou o surgimento do termo Cosmografia Geográfica. A Cosmografia Geográfica é um campo de estudos da Geografia, cujo conjunto de conhecimentos e habilidades é predominantemente escolar. Estuda a interface entre os conhecimentos terrestres e os celestes e lhes atribui significância geográfica. Analisa as relações humanas e naturais com o Espaço Sideral e suas consequências para a sociedade e a natureza. Aunque el concepto de "Cosmografía" no se usa desde la década de los '80 del siglo pasado, los temas astronómicos que se enseñaban anteriormente en las asignaturas escolares de Cosmografía y de Geografía permanecen en los actuales libros didácticos. El uso del término "Cosmografía" fue rescatado en esta investigación y el estudio de su resignificación proporcionó el surgimiento del término Cosmografía Geográfica. La Cosmografía Geográfica es un campo de estudio de la Geografía, donde el conjunto de conocimientos y

Community Readiness Within Systems of Care: The Validity and Reliability of the System of Care Readiness and Implementation Measurement Scale (SOC-RIMS).

Science.gov (United States)

Rosas, Scott R; Behar, Lenore B; Hydaker, William M

2016-01-01

Establishing a system of care requires communities to identify ways to successfully implement strategies and support positive outcomes for children and their families. Such community transformation is complex and communities vary in terms of their readiness for implementing sustainable community interventions. Assessing community readiness and guiding implementation, specifically for the funded communities implementing a system of care, requires a well-designed tool with sound psychometric properties. This scale development study used the results of a previously published concept mapping study to create, administer, and assess the psychometric characteristics of the System of Care Readiness and Implementation Measurement Scale (SOC-RIMS). The results indicate the SOC-RIMS possesses excellent internal consistency characteristics, measures clearly discernible dimensions of community readiness, and demonstrates the target constructs exist within a broad network of content. The SOC-RIMS can be a useful part of a comprehensive assessment in communities where system of care practices, principles, and philosophies are implemented and evaluated.

Digital approach for the design of statistical analog data acquisition on SoCs

OpenAIRE

Adao Antonio de Souza Junior

2005-01-01

With the current demand for mixed-signal SoCs, an increasing number of designers are looking for ADC architectures that can be easily implemented over digital substrates. Since ADC performance is strongly dependent upon physical and electrical features, it gets more difficult for them to benefit from more recent technologies, where these features are more variable. This way, analog signal acquisition is not allowed to follow an evolutionary trend compatible with Moore’s Law. In fact, such tre...

Comments on "Precise model measurements versus theoretical prediction of barrier insertion loss in presence of the ground" [J. Acoust. Soc. Am. 73, 44–54 (1983)

DEFF Research Database (Denmark)

Rasmussen, Karsten Bo

1983-01-01

Some of the theoretical curves in the article by J. Nicolas et al. [J. Acoust. soc. Am. 73, 44–54 (1983)] appear to be erroneous.......Some of the theoretical curves in the article by J. Nicolas et al. [J. Acoust. soc. Am. 73, 44–54 (1983)] appear to be erroneous....

Reduced expression of TAC1, PENK and SOCS2 in Hcrtr-2 mutated narcoleptic dog brain

Directory of Open Access Journals (Sweden)

Mignot Emmanuel

2007-05-01

Full Text Available Abstract Background Narcolepsy causes dramatic behavioral alterations in both humans and dogs, with excessive sleepiness and cataplexy triggered by emotional stimuli. Deficiencies in the hypocretin system are well established as the origin of the condition; both from studies in humans who lack the hypocretin ligand (HCRT and in dogs with a mutation in hypocretin receptor 2 (HCRTR2. However, little is known about molecular alterations downstream of the hypocretin signals. Results By using microarray technology we have screened the expression of 29760 genes in the brains of Doberman dogs with a heritable form of narcolepsy (homozygous for the canarc-1 [HCRTR-2-2] mutation, and their unaffected heterozygous siblings. We identified two neuropeptide precursor molecules, Tachykinin precursor 1 (TAC1 and Proenkephalin (PENK, that together with Suppressor of cytokine signaling 2 (SOCS2, showed reduced expression in narcoleptic brains. The difference was particularly pronounced in the amygdala, where mRNA levels of PENK were 6.2 fold lower in narcoleptic dogs than in heterozygous siblings, and TAC1 and SOCS2 showed 4.4 fold and 2.8 fold decrease in expression, respectively. The results obtained from microarray experiments were confirmed by real-time RT-PCR. Interestingly, it was previously shown that a single dose of amphetamine-like stimulants able to increase wakefulness in the dogs, also produce an increase in the expression of both TAC1 and PENK in mice. Conclusion These results suggest that TAC1, PENK and SOCS2 might be intimately connected with the excessive daytime sleepiness not only in dogs, but also in other species, possibly including humans.

An acceleration system for Laplacian image fusion based on SoC

Science.gov (United States)

Gao, Liwen; Zhao, Hongtu; Qu, Xiujie; Wei, Tianbo; Du, Peng

2018-04-01

Based on the analysis of Laplacian image fusion algorithm, this paper proposes a partial pipelining and modular processing architecture, and a SoC based acceleration system is implemented accordingly. Full pipelining method is used for the design of each module, and modules in series form the partial pipelining with unified data formation, which is easy for management and reuse. Integrated with ARM processor, DMA and embedded bare-mental program, this system achieves 4 layers of Laplacian pyramid on the Zynq-7000 board. Experiments show that, with small resources consumption, a couple of 256×256 images can be fused within 1ms, maintaining a fine fusion effect at the same time.

3D Embedded Reconfigurable SoC for Expediting Magnetometric Space Missions

Science.gov (United States)

Dekoulis, George

2016-07-01

This paper describes the development of a state-of-the-art three-dimensional embedded reconfigurable System-on-Chip (SoC) for accelerating the design of future magnetometric space missions. This involves measurements of planetary magnetic fields or measurements of heliospheric physics events' signatures superimposed on the aggregate measurements of the stronger planetary fields. The functionality of the embedded core is fully customizable, therefore, its operation is independent of the magnetic sensor being used. Standard calibration procedures still apply for setting the magnetometer measurements to the desired initial state and removing any seriatim interference inferred by the adjacent environment. The system acts as a pathfinder for future high-resolution heliospheric space missions.

Study of Reversible Logic Synthesis with Application in SOC: A Review

Science.gov (United States)

Sharma, Chinmay; Pahuja, Hitesh; Dadhwal, Mandeep; Singh, Balwinder

2017-08-01

The prime concern in today’s SOC designs is the power dissipation which increases with technology scaling. The reversible logic possesses very high potential in reducing power dissipation in these designs. It finds its application in latest research fields such as DNA computing, quantum computing, ultra-low power CMOS design and nanotechnology. The reversible circuits can be easily designed using the conventional CMOS technology at a cost of a garbage output which maintains the reversibility. The purpose of this paper is to provide an overview of the developments that have occurred till date in this concept and how the new reversible logic gates are used to design the logic functions.

Protein Interaction Screening for the Ankyrin Repeats and Suppressor of Cytokine Signaling (SOCS) Box (ASB) Family Identify Asb11 as a Novel Endoplasmic Reticulum Resident Ubiquitin Ligase

DEFF Research Database (Denmark)

Andresen, Christina Aaen; Smedegaard, Stine; Sylvestersen, Kathrine Beck

2014-01-01

The Ankyrin and SOCS (Suppressor of Cytokine Signaling) box (ASB) family of proteins function as the substrate recognition subunit in a subset of Elongin-Cullin-SOCS (ECS) E3 ubiquitin ligases. Despite counting with 18 members in humans, the identity of the physiological targets of the Asb protei...

Observation of self-organized criticality (SOC) behavior during edge biasing experiment on TEXTOR

Energy Technology Data Exchange (ETDEWEB)

Xu, Y.H.; Jachmich, S.; Weynants, R.R. [Ecole Royale Militaire/Koninklijke Militaire School, Laboratory for Plasma Physics, Euratom-Belgian State Association, Brussels, Belgium, Partner in the Trilateral Euregio Cluster (Belgium)

2004-07-01

The self-organized criticality (SOC) behavior of the edge plasma transport has been investigated using the fluctuation data measured in the plasma edge and the scrape-off layer of TEXTOR tokamak before and during the edge electrode biasing experiments. In the 'non-shear' discharge phase before biasing, both the potential and density fluctuations clearly exhibit some of the characteristics associated with SOC: (1) existence of f{sup -1} power-law dependence in the frequency spectrum, (2) slowly decaying long tails in the autocorrelation function, (3) values of Hurst parameters larger than 0.5 at all the detected radial locations, (4) non-Gaussian probability density function of fluctuations and (5) radial propagation of avalanche-like events in the edge plasma area. During the biasing phase, with the generation of an edge radial electric field E{sub r} and hence a sheared E{sub r} x B flow, the local turbulence is found to be well de-correlated by the E{sub r} x B velocity shear, consistent with theoretical predictions. Nevertheless, it is concomitantly found that the Hurst parameters are substantially enhanced in the negative flow shear region and in the scrape-off layer as well, which is contrary to theoretical expectation. Implication of these observations to our understanding of plasma transport mechanisms is discussed. (authors)

An OCP Compliant Network Adapter for GALS-based SoC Design Using the MANGO Network-on-Chip

DEFF Research Database (Denmark)

Bjerregaard, Tobias; Mahadevan, Shankar; Olsen, Rasmus Grøndahl

2005-01-01

decouples communication and computation, providing memory-mapped OCP transactions based on primitive message-passing services of the network. Also, it facilitates GALS-type systems, by adapting to the clockless network. This helps leverage a modular SoC design flow. We evaluate performance and cost of 0...

Design and implementation of a reconfigurable mixed-signal SoC based on field programmable analog arrays

Science.gov (United States)

Liu, Lintao; Gao, Yuhan; Deng, Jun

2017-11-01

This work presents a reconfigurable mixed-signal system-on-chip (SoC), which integrates switched-capacitor-based field programmable analog arrays (FPAA), analog-to-digital converter (ADC), digital-to-analog converter, digital down converter , digital up converter, 32-bit reduced instruction-set computer central processing unit (CPU) and other digital IPs on a single chip with 0.18 μm CMOS technology. The FPAA intellectual property could be reconfigured as different function circuits, such as gain amplifier, divider, sine generator, and so on. This single-chip integrated mixed-signal system is a complete modern signal processing system, occupying a die area of 7 × 8 mm 2 and consuming 719 mW with a clock frequency of 150 MHz for CPU and 200 MHz for ADC/DAC. This SoC chip can help customers to shorten design cycles, save board area, reduce the system power consumption and depress the system integration risk, which would afford a big prospect of application for wireless communication. Project supported by the National High Technology and Development Program of China (No. 2012AA012303).

SOCS3 deficiency in leptin receptor-expressing cells mitigates the development of pregnancy-induced metabolic changes

Directory of Open Access Journals (Sweden)

Thais T. Zampieri

2015-03-01

Conclusions: Our study identified the increased hypothalamic expression of SOCS3 as a key mechanism responsible for triggering pregnancy-induced leptin resistance and metabolic adaptations. These findings not only help to explain a common phenomenon of the mammalian physiology, but it may also aid in the development of approaches to prevent and treat gestational metabolic imbalances.

A 6.45 μW Self-Powered SoC With Integrated Energy-Harvesting Power Management and ULP Asymmetric Radios for Portable Biomedical Systems.

Science.gov (United States)

Roy, Abhishek; Klinefelter, Alicia; Yahya, Farah B; Chen, Xing; Gonzalez-Guerrero, Luisa Patricia; Lukas, Christopher J; Kamakshi, Divya Akella; Boley, James; Craig, Kyle; Faisal, Muhammad; Oh, Seunghyun; Roberts, Nathan E; Shakhsheer, Yousef; Shrivastava, Aatmesh; Vasudevan, Dilip P; Wentzloff, David D; Calhoun, Benton H

2015-12-01

This paper presents a batteryless system-on-chip (SoC) that operates off energy harvested from indoor solar cells and/or thermoelectric generators (TEGs) on the body. Fabricated in a commercial 0.13 μW process, this SoC sensing platform consists of an integrated energy harvesting and power management unit (EH-PMU) with maximum power point tracking, multiple sensing modalities, programmable core and a low power microcontroller with several hardware accelerators to enable energy-efficient digital signal processing, ultra-low-power (ULP) asymmetric radios for wireless transmission, and a 100 nW wake-up radio. The EH-PMU achieves a peak end-to-end efficiency of 75% delivering power to a 100 μA load. In an example motion detection application, the SoC reads data from an accelerometer through SPI, processes it, and sends it over the radio. The SPI and digital processing consume only 2.27 μW, while the integrated radio consumes 4.18 μW when transmitting at 187.5 kbps for a total of 6.45 μW.

The Impact of Strong Cathodic Polarization on SOC Electrolyte Materials

DEFF Research Database (Denmark)

Kreka, Kosova; Hansen, Karin Vels; Jacobsen, Torben

2016-01-01

One of the most promising reversible energy conversion/storage technologies is that of Solid Oxide Fuel/Electrolysis Cells (SOFC/SOEC, collectively termed SOC). Long term durability is typically required for such devises to become economically feasible, hence considerable amount of work has...... of impurities at the grain boundaries, electrode poisoning, delamination or cracks of the electrolyte etc., have been observed in cells operated at such conditions, lowering the lifetime of the cell1,2. High polarizations are observed at the electrolyte/cathode interface of an electrolysis cell operated at high...... current density. In case of a cell voltage above 1.6 V, p-type and n-type electronic conductivity are often observed at the anode and cathode respectively3. Hence, a considerable part of the current is lost as leakage through the electrolyte, thus lowering the efficiency of the cell considerably....

Hypomethylation of inflammatory genes (COX2, EGR1, and SOCS3) and increased urinary 8-nitroguanine in arsenic-exposed newborns and children

Energy Technology Data Exchange (ETDEWEB)

Phookphan, Preeyaphan; Navasumrit, Panida [Laboratory of Environmental Toxicology, Chulabhorn Research Institute, Laksi, Bangkok (Thailand); Post-graduate Program in Environmental Toxicology, Chulabhorn Graduate Institute, Laksi, Bangkok (Thailand); Center of Excellence on Environmental Health, Toxicology (EHT), Office of the Higher Education Commission, Ministry of Education (Thailand); Waraprasit, Somchamai; Promvijit, Jeerawan; Chaisatra, Krittinee; Ngaotepprutaram, Thitirat [Laboratory of Environmental Toxicology, Chulabhorn Research Institute, Laksi, Bangkok (Thailand); Ruchirawat, Mathuros, E-mail: mathuros@cri.or.th [Laboratory of Environmental Toxicology, Chulabhorn Research Institute, Laksi, Bangkok (Thailand); Center of Excellence on Environmental Health, Toxicology (EHT), Office of the Higher Education Commission, Ministry of Education (Thailand)

2017-02-01

Early-life exposure to arsenic increases risk of developing a variety of non-malignant and malignant diseases. Arsenic-induced carcinogenesis may be mediated through epigenetic mechanisms and pathways leading to inflammation. Our previous study reported that prenatal arsenic exposure leads to increased mRNA expression of several genes related to inflammation, including COX2, EGR1, and SOCS3. This study aimed to investigate the effects of arsenic exposure on promoter DNA methylation and mRNA expression of these inflammatory genes (COX2, EGR1, and SOCS3), as well as the generation of 8-nitroguanine, which is a mutagenic DNA lesion involved in inflammation-related carcinogenesis. Prenatally arsenic-exposed newborns had promoter hypomethylation of COX2, EGR1, and SOCS3 in cord blood lymphocytes (p < 0.01). A follow-up study in these prenatally arsenic-exposed children showed a significant hypomethylation of these genes in salivary DNA (p < 0.01). In vitro experiments confirmed that arsenite treatment at short-term high doses (10–100 μM) and long-term low doses (0.5–1 μM) in human lymphoblasts (RPMI 1788) caused promoter hypomethylation of these genes, which was in concordance with an increase in their mRNA expression. Additionally, the level of urinary 8-nitroguanine was significantly higher (p < 0.01) in exposed newborns and children, by 1.4- and 1.8-fold, respectively. Arsenic accumulation in toenails was negatively correlated with hypomethylation of these genes and positively correlated with levels of 8-nitroguanine. These results indicated that early-life exposure to arsenic causes hypomethylation of COX2, EGR1, and SOCS3, increases mRNA expression of these genes, and increases 8-nitroguanine formation. These effects may be linked to mechanisms of arsenic-induced inflammation and cancer development later in life. - Highlight: • Early-life arsenic exposure caused promoter hypomethylation of COX2, EGR1 and SOCS3. • Hypomethylation of these genes is

Hypomethylation of inflammatory genes (COX2, EGR1, and SOCS3) and increased urinary 8-nitroguanine in arsenic-exposed newborns and children

International Nuclear Information System (INIS)

Phookphan, Preeyaphan; Navasumrit, Panida; Waraprasit, Somchamai; Promvijit, Jeerawan; Chaisatra, Krittinee; Ngaotepprutaram, Thitirat; Ruchirawat, Mathuros

2017-01-01

Early-life exposure to arsenic increases risk of developing a variety of non-malignant and malignant diseases. Arsenic-induced carcinogenesis may be mediated through epigenetic mechanisms and pathways leading to inflammation. Our previous study reported that prenatal arsenic exposure leads to increased mRNA expression of several genes related to inflammation, including COX2, EGR1, and SOCS3. This study aimed to investigate the effects of arsenic exposure on promoter DNA methylation and mRNA expression of these inflammatory genes (COX2, EGR1, and SOCS3), as well as the generation of 8-nitroguanine, which is a mutagenic DNA lesion involved in inflammation-related carcinogenesis. Prenatally arsenic-exposed newborns had promoter hypomethylation of COX2, EGR1, and SOCS3 in cord blood lymphocytes (p < 0.01). A follow-up study in these prenatally arsenic-exposed children showed a significant hypomethylation of these genes in salivary DNA (p < 0.01). In vitro experiments confirmed that arsenite treatment at short-term high doses (10–100 μM) and long-term low doses (0.5–1 μM) in human lymphoblasts (RPMI 1788) caused promoter hypomethylation of these genes, which was in concordance with an increase in their mRNA expression. Additionally, the level of urinary 8-nitroguanine was significantly higher (p < 0.01) in exposed newborns and children, by 1.4- and 1.8-fold, respectively. Arsenic accumulation in toenails was negatively correlated with hypomethylation of these genes and positively correlated with levels of 8-nitroguanine. These results indicated that early-life exposure to arsenic causes hypomethylation of COX2, EGR1, and SOCS3, increases mRNA expression of these genes, and increases 8-nitroguanine formation. These effects may be linked to mechanisms of arsenic-induced inflammation and cancer development later in life. - Highlight: • Early-life arsenic exposure caused promoter hypomethylation of COX2, EGR1 and SOCS3. • Hypomethylation of these genes is

Egr2 enhances insulin resistance via JAK2/STAT3/SOCS-1 pathway in HepG2 cells treated with palmitate.

Science.gov (United States)

Lu, Lin; Ye, Xinhua; Yao, Qing; Lu, Aijiao; Zhao, Zhen; Ding, Yang; Meng, Chuchen; Yu, Wenlong; Du, Yunfeng; Cheng, JinLuo

2018-05-01

Insulin resistance is generally responsible for the pathogenesis of type 2 diabetes mellitus (T2DM). Early growth response proteins-2 (Egr2) has been reported to be able to increase the expression of the suppressors of cytokine signaling-1 (SOCS-1), and impair insulin signaling pathway through suppression of insulin receptor substrates (IRS), including IRS-1 and IRS-2. However, whether Egr2 is directly involved in the development of insulin resistance, and how its potential contributions to insulin resistance still remain unknown. Here, our present investigation found that the expression levels of Egr2 were up-regulated when insulin resistance occurs, and knockdown of Egr2 abolished the effect of insulin resistance in HepG2 cells induced with palmitate (PA). Importantly, inhibition of Egr2 decreased the expression of SOCS-1 as well as reduced phosphorylation of JAK2 and STAT3. And, our data indicated that silencing of Egr2 accelerated hepatic glucose uptake and reversed the impaired lipid metabolism upon insulin resistance. In summary, the present study confirms that Egr2 could deteriorate insulin resistance via the pathway of JAK2/STAT3/SOCS-1 and may shed light on resolving insulin resistance and further the pathogenesis of T2DM. Copyright © 2017 Elsevier Inc. All rights reserved.

Perception SoC Based on an Ultrasonic Array of Sensors: Efficient DSP Core Implementation and Subsequent Experimental Results

Directory of Open Access Journals (Sweden)

A. Haidar

2005-05-01

Full Text Available We are concerned with the design, implementation, and validation of a perception SoC based on an ultrasonic array of sensors. The proposed SoC is dedicated to ultrasonic echography applications. A rapid prototyping platform is used to implement and validate the new architecture of the digital signal processing (DSP core. The proposed DSP core efficiently integrates all of the necessary ultrasonic B-mode processing modules. It includes digital beamforming, quadrature demodulation of RF signals, digital filtering, and envelope detection of the received signals. This system handles 128 scan lines and 6400 samples per scan line with a 90° angle of view span. The design uses a minimum size lookup memory to store the initial scan information. Rapid prototyping using an ARM/FPGA combination is used to validate the operation of the described system. This system offers significant advantages of portability and a rapid time to market.

Perception SoC Based on an Ultrasonic Array of Sensors: Efficient DSP Core Implementation and Subsequent Experimental Results

Science.gov (United States)

Kassem, A.; Sawan, M.; Boukadoum, M.; Haidar, A.

2005-12-01

We are concerned with the design, implementation, and validation of a perception SoC based on an ultrasonic array of sensors. The proposed SoC is dedicated to ultrasonic echography applications. A rapid prototyping platform is used to implement and validate the new architecture of the digital signal processing (DSP) core. The proposed DSP core efficiently integrates all of the necessary ultrasonic B-mode processing modules. It includes digital beamforming, quadrature demodulation of RF signals, digital filtering, and envelope detection of the received signals. This system handles 128 scan lines and 6400 samples per scan line with a[InlineEquation not available: see fulltext.] angle of view span. The design uses a minimum size lookup memory to store the initial scan information. Rapid prototyping using an ARM/FPGA combination is used to validate the operation of the described system. This system offers significant advantages of portability and a rapid time to market.

Soc stock in different forest-related land-uses in central Stara planina mountain, Bulgaria

Directory of Open Access Journals (Sweden)

Zhiyanski Miglena

2009-01-01

Full Text Available Forest conversions may lead to an accumulation of carbon in vegetation, but little is known about changes in soil C storage with establishment of plantation forests. Understanding these effects is important to addressing issues relevant to ecosystem function and productivity, and to global balance of carbon. The study investigated the effects of the created coniferous plantations on former beech and pasture sites on the soil organic carbon storage. The major forest-related land-uses in the high mountainous regions of central Stara Planina Mountain were investigated: mountainous pasture, coniferous plantations (planted on previous pasture and beech forests between four and five decades ago and natural beech forests. The experimental data of soil properties, conducted in 2005, 2006 and 2007, were used in determining the variations in organic carbon storage in forest litter and in mineral soil under different land-use patterns. At each site five representative soil profiles were opened and described giving a total 75 soil samples from the soil layers respectively at 0-10, 10-30 and 30-50 cm depth. A total of 55 samples from forest floor layers (Aol, Aof, Aoh and greensward were collected with 25:25 cm plastic frame. The main soil properties were determined in accordance with the standardized methods in the Laboratory of soil science at the Forest Research Institute - BAS. The IPCC Good Practice Guidance for Land Use, Land Use Change and Forestry was used to estimate the soil organic carbon stock in soil and litter. The results obtained showed that the SOC stock was quite similar among forest land-uses. The conversion of natural beech forests to coniferous plantations in studied region is related with slightly expressed decrease in soil carbon storage. The values of SOC stocks in 0-50 cm soil layer in these sites were 8.5 (±2.1 tones/ha for pine and 11.0 (±1.4 tones/ha for spruce, while under the natural beech forest it was 14.8 (±1.0 tones

One-chip Integrated Module of MEMS Shock Sensor and Sensing Amplifier LSI using Pseudo-SOC Technology

Science.gov (United States)

Iida, Atsuko; Onozuka, Yutaka; Nishigaki, Michihiko; Yamada, Hiroshi; Funaki, Hideyuki; Itaya, Kazuhiko

We have been developing the pseudo-SOC technology for one-chip module integration of heterogeneous devices that realizes high electrical performance and high density of devices embodying the advantages of both SOC technology and SIP technology. Especially, this technology is available for MEMS-LSI integration. We developed a 0.2mm-thickness one-chip module integrating a MEMS shock sensor and a sensing amplifier LSI by applying this technology. The MEMS shock sensor and the sensing amplifier LSI were connected by high-rigidity epoxy resin optimized the material constants to reduce the stress and the warpage resulting from resin shrinkage due to curing. Then the planar insulating layer and the redistributed conducting layer were formed on it for the global layer. The MEMS shock sensor was preformed to be modularized with a glass cap. Electrical contacts were achieved by bonding of Au bumps on the MEMS fixed electrodes and via holes filled with Ag paste of the glass cap. Functional performance was confirmed by obtaining signal corresponding to the reference signal of the pick-up sensor. Furthermore, stress analysis was performed using the FEM model simulation considering the resin shrinkage.

Inflammation and linear bone growth: the inhibitory role of SOCS2 on GH/IGF-1 signaling.

Science.gov (United States)

Farquharson, Colin; Ahmed, S Faisal

2013-04-01

Linear bone growth is widely recognized to be adversely affected in children with chronic kidney disease (CKD) and other chronic inflammatory disorders. The growth hormone (GH)/insulin-like growth factor-1 (IGF-1) pathway is anabolic to the skeleton and inflammatory cytokines compromise bone growth through a number of different mechanisms, which include interference with the systemic as well as the tissue-level GH/IGF-1 axis. Despite attempts to promote growth and control disease, there are an increasing number of reports of the persistence of poor growth in a substantial proportion of patients receiving rhGH and/or drugs that block cytokine action. Thus, there is an urgent need to consider better and alternative forms of therapy that are directed specifically at the mechanism of the insult which leads to abnormal bone health. Suppressor of cytokine signaling 2 (SOCS2) expression is increased in inflammatory conditions including CKD, and is a recognized inhibitor of GH signaling. Therefore, in this review, we will focus on the premise that SOCS2 signaling represents a critical pathway in growth plate chondrocytes through which pro-inflammatory cytokines alter both GH/IGF-1 signaling and cellular function.

Gas-particle partitioning of semivolatile organic compounds (SOCs) on mixtures of aerosols in a smog chamber.

Science.gov (United States)

Chandramouli, Bharadwaj; Jang, Myoseon; Kamens, Richard M

2003-09-15

The partitioning behavior of a set of diverse SOCs on two and three component mixtures of aerosols from different sources was studied using smog chamber experimental data. A set of SOCs of different compound types was introduced into a system containing a mixture of aerosols from two or more sources. Gas and particle samples were taken using a filter-filter-denuder sampling system, and a partitioning coefficient Kp was estimated using Kp = Cp/(CgTSP). Particle size distributions were measured using a differential mobility analyzer and a light scattering detector. Gas and particle samples were analyzed using GCMS. The aerosol composition in the chamber was tracked chemically using a combination of signature compounds and the organic matter mass fraction (f(om)) of the individual aerosol sources. The physical nature of the aerosol mixture in the chamber was determined using particle size distributions, and an aggregate Kp was estimated from theoretically calculated Kp on the individual sources. Model fits for Kp showed that when the mixture involved primary sources of aerosol, the aggregate Kp of the mixture could be successfully modeled as an external mixture of the Kp on the individual aerosols. There were significant differences observed for some SOCs between modeling the system as an external and as an internal mixture. However, when one of the aerosol sources was secondary, the aggregate model Kp required incorporation of the secondary aerosol products on the preexisting aerosol for adequate model fits. Modeling such a system as an external mixture grossly overpredicted the Kp of alkanes in the mixture. Indirect evidence of heterogeneous, acid-catalyzed reactions in the particle phase was also seen, leading to a significant increase in the polarity of the resulting aerosol mix and a resulting decrease in the observed Kp of alkanes in the chamber. The model was partly consistent with this decrease but could not completely explain the reduction in Kp because of

The SOC in cells’ living expectations of Conway’s Game of Life and its extended version

International Nuclear Information System (INIS)

Wei, Jinling; Zhou, Haiyan; Meng, Jun; Zhang, Fan; Chen, Yunmo; Zhou, Su

2016-01-01

In self-organized systems such as Conway’s Game of Life (CGL). Wikipedia, Conway’s game of the life, (https://en.wikipedia.org/wiki/Conway%27s-Game-of-Life)., though whether the single cell will survive or die seems unpredictable, the log–log distribution of all cells living frequency satisfies the 1/f linear law, thus meets the Self-organized Criticality(SOC) rule, which not only proves that CGL is a self-organized system, but more significantly, that the chance of living for each cell is spatial heterogeneous, and is statistical fractal. After carried out CGL, the specified iterative period which begins with a random initial condition and ends when it reaches the homeostasis, add up all the states which the living cells are marked by 1s, and the dead are marked by 0s. The resulted sum picture consisting of cells having its gray level representing the living times during the iterative process. By plotting the gray level distribution of the sum picture on log–log scale, the graph indicates the spatial living expectations distributions. Then we find the curve of the graph satisfies the Self-organized Criticality(SOC) rule, showing its linear feature in the intermediate zone, which also has name of 1/f feature. To examine its universality, we designed a more complicated self-organized cellular automata with each cell having five possible states thus the rule table becomes more complicated. As expected, the consequence shows the similar feature, and the linear feature is even more obvious when the similar experiments are carried out. To conclude, it is a new discovery of SOC from a new perspective. And with the self-organized systems expanding to other different rule tables, this feature may still be satisfied. More further, considering the natural self-organized systems of living creatures, the spatial living expectations of different phenotypes may satisfy the 1/f law, too. Though we regard this as an inspirational orientation, the supposition needs more

Architectures, Concepts and Architectures for Service Oriented Computing : proceedings of the 1st International Workshop - ACT4SOC 2007

NARCIS (Netherlands)

van Sinderen, Marten J.; Unknown, [Unknown

2007-01-01

This volume contains the proceedings of the First International Workshop on Architectures, Concepts and Technologies for Service Oriented Computing (ACT4SOC 2007), held on July 22 in Barcelona, Spain, in conjunction with the Second International Conference on Software and Data Technologies (ICSOFT

A project to study SOC evolution after land use change combining chronosequence and gradient methods

Science.gov (United States)

Gabarron-Galeote, Miguel A.; van Wesemael, Bas

2013-04-01

In the last decades the interest in the global C budget has increased enormously and soils have a great importance in this issue since they contain about twice as much carbon as the atmosphere. Land use change (LUC) can cause a change in land cover and an associated change in carbon stocks in soils, so it has a major impact in the balance between inputs and outputs of soil organic carbon (SOC). Improved understanding of land-use impacts on the world's terrestrial carbon balance is thus a necessary part of the global effort to mitigate climate change. The aim of this project is to predict the effects of land use and land management change on (SOC) stocks, characterizing the soil organic carbon cycle and its relationship to the vegetal cover in croplands abandoned different years ago and under different Mediterranean climatic conditions in South of Spain. The study area is located in the Cordillera Bética Litoral, in South of Spain. In this area, a climatic gradient can be observed from West to East: from >1,500 mm year-1 in the Strait of Gibraltar to <250 mm year-1 in the Cabo de Gata. More specifically, the study is focussed on three different areas from the climatic conditions point of view: Gaucín (1010 mm year-1), Almogía, (576 mm year-1) and Gérgal (240 mm year-1). By means of the analyses of aerial photographs (1956, 1977, 1984, 1998 and 2009) all the experimental plots will be selected. After this procedure, the three study areas will be composed by experimental plots of these classes: a) Lands with natural vegetation since 1956. b) Abandoned lands between 1956 and 1977. c) Abandoned lands between 1977 and 1984. d) Abandoned lands between 1984 and 1998. e) Abandoned lands between 1998 and 2005. f) Cultivated lands since 1956. The main expected outcomes of the research project are the characterization of the temporal evolution of SOC in soils, the compilation of experimental areas under different Mediterranean climatic conditions, and the characterization

Semivolatile Organic Compounds (SOCs) in Fine Particulate Matter (PM2.5) during Clear, Fog, and Haze Episodes in Winter in Beijing, China.

Science.gov (United States)

Wang, Ting; Tian, Mi; Ding, Nan; Yan, Xiao; Chen, She-Jun; Mo, Yang-Zhi; Yang, Wei-Qiang; Bi, Xin-Hui; Wang, Xin-Ming; Mai, Bi-Xian

2018-05-01

Few efforts have been made to elucidate the influence of weather conditions on the fate of semivolatile organic compounds (SOCs). Here, daily fine particulate matter (PM 2.5 ) during clear, haze, and fog episodes collected in the winter in Beijing, China was analyzed for polycyclic aromatic hydrocarbons (PAHs), brominated flame retardants (BFRs), and organophosphate flame retardants (OPFRs). The total concentrations of PAHs, OPFRs, and BFRs had medians of 45.1 ng/m 3 and 1347 and 46.7 pg/m 3 , respectively. The temporal pattern for PAH concentrations was largely dependent on coal combustion for residential heating. OPFR compositions that change during colder period were related to enhanced indoor emissions due to heating. The mean concentrations of SOCs during haze and fog days were 2-10 times higher than those during clear days. We found that BFRs with lower octanol and air partition coefficients tended to increase during haze and fog episodes, be removed from PM 2.5 during clear episodes, or both. For PAHs and OPFRs, pollutants that are more recalcitrant to degradation were prone to accumulate during haze and fog days. The potential source contribution function (PSCF) model indicated that southern and eastern cities were major source regions of SOCs at this site.

The effect of interferon treatment on STAT/SOCS status in normal and malignant human breast cells

Czech Academy of Sciences Publication Activity Database

Součková Skalická, Kamila; Adámková, L.; Lauerová, L.; Krejčí, E.; Kovařík, Aleš; Fojtová, Miloslava; Matoušková, Eva; Buršíková, Eva; Kovařík, J.; Boudný, V.

2006-01-01

Roč. 17, č. 9 (2006), ix65-ix65 ISSN 0923-7534. [31st ESMO Congress. 29.09.2006-03.10.2006, Istanbul] R&D Projects: GA MZd(CZ) NR8341; GA ČR(CZ) GA301/06/0912; GA AV ČR(CZ) KJB502070601 Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50520514 Keywords : interferon * breast * STAT/SOCS Subject RIV: BO - Biophysics

Development of control system for multi-converter high voltage power supply using programmable SoC

International Nuclear Information System (INIS)

Dave, Rasesh; Singh, N.P.; Thakar, Aruna; Dhola, Hitesh; Gajjar, Sandip; Parmar, Darshan Kumar; Baruah, Ujjwal Kumar; Dharangutti, Jagruti; Zaveri, Tanish

2015-01-01

Multi-converter based High Voltage Power Supplies (HVPSs) find application in multi-megawatt accelerators, RF systems. Control system for HVPS must be a combination of superior parallel processing, real time performance, fast computation and versatile connectivity. The hardware platform is expected to be robust, easily scalable for future developments without any cost overhead. Typical HVPS control mechanism involves communication, generation of precise control signals/pulses for few hundred Nos of chopper and closed loop control in microsecond range for regulated output. Such kind of requirements can be met with Zynq All Programmable SoC, which is a combination of Dual core ARM Cortex A-9 Processing System (PS) and Xilinx 7 series FPGA based Programmable Logic (PL). Deterministic functions of power supply control system such as generation of control signals with precise inter-channel delay of nanosecond range and communication with individual chopper at 100kbps can be implemented on PL. PS should implement corrective tasks based on field feedback received from individual chopper, user interface and OS management that allows to take full advantage of system capabilities. PS and PL are connected with on-chip AXI-4 interface with low latency and higher bandwidth through 9 AXI ports. Typically PS boots first, this ensures secure booting and prevents external environment from tampering PL. This paper describes development of control system on Zynq All Programmable SoC for HVPS. (author)

Development of control system for multi-converter High voltage Power supply using programmable SoC

Science.gov (United States)

Dave, Rasesh; Dharangutti, Jagruti; Singh, N. P.; Thakar, Aruna; Dhola, Hitesh; Gajjar, Sandip; Parmar, Darshan; Zaveri, Tanish; Baruah, Ujjwal

2017-04-01

Multi-converter based High Voltage Power Supplies (HVPSs) find application in multi-megawatt accelerators, RF systems. Control system for HVPS must be a combination of superior parallel processing, real time performance, fast computation and versatile connectivity. The hardware platform is expected to be robust, easily scalable for future developments with minimal overheads. This paper describes development of control system on Zynq All Programmable SoC (System on Chip) for HVPS. Typical HVPS control mechanism involves communication, generation of precise control signals/pulses for few hundred numbers of chopper and closed loop control in microsecond range for regulated output. Such kind of requirements can be met with Zynq All Programmable SoC, which is a combination of Dual core ARM Cortex A-9 Processing System (PS) and Xilinx 7 series FPGA based Programmable Logic (PL). Deterministic functions of power supply control system such as generation of control signals with precise inter-channel delay of nanosecond range and communication with individual chopper at 100kbps can be implemented on PL. PS should implement corrective tasks based on field feedback received from individual chopper, user interface and OS management that allows to take full advantage of system capabilities. PS and PL are connected with on-chip AXI-4 interface with low latency and higher bandwidth through 9 AXI ports. Typically PS boots first, this ensures secure booting and prevents external environment from tampering PL.

A fully integrated UHF RFID reader SoC for handheld applications in the 0.18 {mu}m CMOS process

Energy Technology Data Exchange (ETDEWEB)

Wang Jingchao; Zhang Chun; Wang Zhihua, E-mail: wangjc@gmail.co [Institute of Microelectronics, Tsinghua University, Beijing 100084 (China)

2010-08-15

A low cost fully integrated single-chip UHF radio frequency identification (RFID) reader SoC for short distance handheld applications is presented. The SoC integrates all building blocks-including an RF transceiver, a PLL frequency synthesizer, a digital baseband and an MCU-in a 0.18 {mu}m CMOS process. A high-linearity RX front-end is designed to handle the large self-interferer. A class-E power amplifier with high power efficiency is also integrated to fulfill the function of a UHF passive RFID reader. The measured maximum output power of the transmitter is 20.28 dBm and the measured receiver sensitivity is -60 dBm. The digital baseband including MCU core consumes 3.91 mW with a clock of 10 MHz and the analog part including power amplifier consumes 368.4 mW. The chip has a die area of 5.1 x 3.8 mm{sup 2} including pads. (semiconductor integrated circuits)

A fully integrated UHF RFID reader SoC for handheld applications in the 0.18 μm CMOS process

International Nuclear Information System (INIS)

Wang Jingchao; Zhang Chun; Wang Zhihua

2010-01-01

A low cost fully integrated single-chip UHF radio frequency identification (RFID) reader SoC for short distance handheld applications is presented. The SoC integrates all building blocks-including an RF transceiver, a PLL frequency synthesizer, a digital baseband and an MCU-in a 0.18 μm CMOS process. A high-linearity RX front-end is designed to handle the large self-interferer. A class-E power amplifier with high power efficiency is also integrated to fulfill the function of a UHF passive RFID reader. The measured maximum output power of the transmitter is 20.28 dBm and the measured receiver sensitivity is -60 dBm. The digital baseband including MCU core consumes 3.91 mW with a clock of 10 MHz and the analog part including power amplifier consumes 368.4 mW. The chip has a die area of 5.1 x 3.8 mm 2 including pads. (semiconductor integrated circuits)

Suppressor of cytokine signalling (SOCS)-3 protects beta cells against IL-1beta-mediated toxicity through inhibition of multiple nuclear factor-kappaB-regulated proapoptotic pathways

DEFF Research Database (Denmark)

Karlsen, Allan Ertman; Heding, P E; Frobøse, H

2004-01-01

The proinflammatory cytokine IL-1beta induces apoptosis in pancreatic beta cells via pathways dependent on nuclear factor-kappaB (NF-kappaB), mitogen-activated protein kinase, and protein kinase C. We recently showed suppressor of cytokine signalling (SOCS)-3 to be a natural negative feedback reg...... regulator of IL-1beta- and IFN-gamma-mediated signalling in rat islets and beta cell lines, preventing their deleterious effects. However, the mechanisms underlying SOCS-3 inhibition of IL-1beta signalling and prevention against apoptosis remain unknown....

Highly monodisperse M III-based soc -MOFs (M = in and Ga) with cubic and truncated cubic morphologies

KAUST Repository

Pang, Maolin

2012-08-15

In this work, we carry out an investigation on shape-controlled growth of In III- and Ga III-based square-octahedral metal-organic frameworks (soc-MOFs). In particular, controllable crystal morphological evolution from simple cubes to complex octadecahedra has been achieved, and resultant highly uniform crystal building blocks promise new research opportunities for preparation of self-assembled MOF materials and related applications. © 2012 American Chemical Society.

Highly monodisperse M III-based soc -MOFs (M = in and Ga) with cubic and truncated cubic morphologies

KAUST Repository

Pang, Maolin; Cairns, Amy; Liu, Yunling; Belmabkhout, Youssef; Zeng, Huachun; Eddaoudi, Mohamed

2012-01-01

In this work, we carry out an investigation on shape-controlled growth of In III- and Ga III-based square-octahedral metal-organic frameworks (soc-MOFs). In particular, controllable crystal morphological evolution from simple cubes to complex octadecahedra has been achieved, and resultant highly uniform crystal building blocks promise new research opportunities for preparation of self-assembled MOF materials and related applications. © 2012 American Chemical Society.

What can we learn from field experiments about the development of SOC and GHG emissions under different management practices?

Science.gov (United States)

Spiegel, Heide; Lehtinen, Taru; Schlatter, Norman; Haslmayr, Hans-Peter; Baumgarten, Andreas; ten Berge, Hein

2015-04-01

Successful agricultural management practices are required to maintain or enhance soil quality; at the same time climate change mitigation is becoming increasingly important. Within the EU project CATCH-C we analysed the effects of different agricultural practices not only on crop productivity, but also on soil quality indicators (e.g. soil organic carbon (SOC)) and climate change (CC) mitigation indicators (e.g. CO2, CH4, N2O emissions). European data sets and associated literature, mainly from long-term experiments were evaluated. This evaluation of agricultural management practices was carried out comparing a set of improved ("best") and often applied ("current") management practices. Positive and negative effects occurred when best management practices are adopted. As expected, none of the investigated practices could comply with all objectives simultaneously, i.e. maintaining high yields, mitigating climate change and improving chemical, physical and biological soil quality. The studied soil management practices "non-inversion tillage", "organic fertilisation" (application of farm yard manure, slurry, compost) and "incorporation of crop residues" represent important management practices for farmers to increase SOC, thus improving soil quality. However, CO2 and, especially, N2O emissions may rise as well. The evaluation of CC mitigation is often limited by the lack of data from - preferably - continuous GHG emission measurements. Thus, more long-term field studies are needed to better assess the CO2, CH4 and, especially, N2O emissions following the above mentioned favorably rated MPs. Only if SOC and GHG emissions are measured in the same field experiments, it will be possible to compute overall balances of necessary CO2-C equivalent emissions. CATCH-C is funded within the 7th Framework Programme for Research, Technological Development and Demonstration, Theme 2 - Biotechnologies, Agriculture & Food. (Grant Agreement N° 289782).

A 10-bit 200-kS/s SAR ADC IP core for a touch screen SoC

International Nuclear Information System (INIS)

Tong Xingyuan; Yang Yintang; Zhu Zhangming; Sheng Wenfang

2010-01-01

Based on a 5 MSBs (most-significant-bits)-plus-5 LSBs (least-significant-bits) C-R hybrid D/A conversion and low-offset pseudo-differential comparison approach, with capacitor array axially symmetric layout topology and resistor string low gradient mismatch placement method, an 8-channel 10-bit 200-kS/s SAR ADC (successive-approximation-register analog-to-digital converter) IP core for a touch screen SoC (system-on-chip) is implemented in a 0.18 μm 1P5M CMOS logic process. Design considerations for the touch screen SAR ADC are included. With a 1.8 V power supply, the DNL (differential non-linearity) and INL (integral non-linearity) of this converter are measured to be about 0.32 LSB and 0.81 LSB respectively. With an input frequency of 91 kHz at 200-kS/s sampling rate, the spurious-free dynamic range and effective-number-of-bits are measured to be 63.2 dB and 9.15 bits respectively, and the power is about 136 μW. This converter occupies an area of about 0.08 mm 2 . The design results show that it is very suitable for touch screen SoC applications. (semiconductor integrated circuits)

Combined action of taurine and cations of certain metals on post-irradiation survival of SOC cell culture

International Nuclear Information System (INIS)

Yartsev, E.I.; Aldonyasov, V.I.; Yakovlev, V.G.

1975-01-01

Effects of combined application of taurine and metals (potassium, magnesium, calcium and zinc) on the cell level have been studied. It has been found that various concentrations of taurine and potassium and zinc salts increase the survival of irradiated SOC cells up to 40% while addition of magnesium and calcium salts does not affect the taurine effectiveness. The highest effectiveness is obtained when potassium and taurine are added in equimolar amounts to the incubation medium

Inducibility of STAT 1/SOCS 3 transcripts and proteins by interferon-alpha/gamma in human melanoma cell lines

Czech Academy of Sciences Publication Activity Database

Kovařík, Aleš; Fojtová, Miloslava; Boudný, V.; Adamková, L.; Kovařík, J.

2004-01-01

Roč. 14, Suppl. 1 (2004), s. S87 ISSN 1107-3756. [World Congress on Advances in Oncology /9./ and International Symposium on Molecular Medicine /7./. 14.10.2004-16.10.2004, Hersonissos] R&D Projects: GA MZd NC7139; GA ČR GA301/03/0370; GA AV ČR IBS5004010 Keywords : melanoma cells * STAT 1 * SOCS 3 Subject RIV: BO - Biophysics

Benthic faunal composition along Princess Astrid Coast, East Antarctica

Digital Repository Service at National Institute of Oceanography (India)

Sreepada, R.A; Jayasree, V.; Parulekar, A

stream_size 5 stream_content_type text/plain stream_name DOD_Tech_Publ_1995_8_181.pdf.txt stream_source_info DOD_Tech_Publ_1995_8_181.pdf.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 ...

Co-verification of hardware and software for ARM SoC design

CERN Document Server

Andrews, Jason

2004-01-01

Hardware/software co-verification is how to make sure that embedded system software works correctly with the hardware, and that the hardware has been properly designed to run the software successfully -before large sums are spent on prototypes or manufacturing. This is the first book to apply this verification technique to the rapidly growing field of embedded systems-on-a-chip(SoC). As traditional embedded system design evolves into single-chip design, embedded engineers must be armed with the necessary information to make educated decisions about which tools and methodology to deploy. SoC verification requires a mix of expertise from the disciplines of microprocessor and computer architecture, logic design and simulation, and C and Assembly language embedded software. Until now, the relevant information on how it all fits together has not been available. Andrews, a recognized expert, provides in-depth information about how co-verification really works, how to be successful using it, and pitfalls to avoid. H...

PSR B0329+54: substructure in the scatter-broadened image discovered with RadioAstron on baselines up to 330 000 km

Science.gov (United States)

Popov, Mikhail V.; Bartel, Norbert; Gwinn, Carl R.; Johnson, Michael D.; Andrianov, Andrey; Fadeev, Evgeny; Joshi, Bhal Chandra; Kardashev, Nikolay; Karuppusamy, Ramesh; Kovalev, Yuri Y.; Kramer, Michael; Rudnitskiy, Alexey; Shishov, Vladimir; Smirnova, Tatiana; Soglasnov, Vladimir A.; Zensus, J. Anton

2017-02-01

We have resolved the scatter-broadened image of PSR B0329+54 and detected a substructure within it. These results are not influenced by any extended structure of a source but instead are directly attributed to the interstellar medium. We obtained these results at 324 MHz with the ground-space interferometer RadioAstron, which included the Space Radio Telescope, ground-based Westerbork Synthesis Radio Telescope and 64-m Kalyazin Radio Telescope on baseline projections up to 330 000 km in 2013 November 22 and 2014 January 1 to 2. At short 15 000 to 35 000 km ground-space baseline projections, the visibility amplitude decreases with baseline length, providing a direct measurement of the size of the scattering disc of 4.8 ± 0.8 mas. At longer baselines, no visibility detections from the scattering disc would be expected. However, significant detections were obtained with visibility amplitudes of 3 to 5 per cent of the maximum scattered around a mean and approximately constant up to 330 000 km. These visibilities reflect a substructure from scattering in the interstellar medium and offer a new probe of ionized interstellar material. The size of the diffraction spot near Earth is 17 000 ± 3 000 km. With the assumption of turbulent irregularities in the plasma of the interstellar medium, we estimate that the effective scattering screen is located 0.6 ± 0.1 of the distance from the Earth towards the pulsar.

Intense predation on ascidians by a trunk fish, Ostracion immaculatus (Temminck et Schlege) (Pisces:Ostracidae)

Digital Repository Service at National Institute of Oceanography (India)

Raveendran, T.V.; Harada, E.

stream_size 9 stream_content_type text/plain stream_name Publ_Seto_Mar_Biol_Lab_37_193.pdf.txt stream_source_info Publ_Seto_Mar_Biol_Lab_37_193.pdf.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 ...

Mapping the variation of soil organic carbon (SOC) stock in time and space in Sicily, an extremely variable semi-arid Mediterranean region, highlighted that C was lost in area rich in organic C and gained in poor-C areas

Science.gov (United States)

Schillaci, Calogero; Acutis, Marco; Lombardo, Luigi; Lipani, Aldo; Fantappiè, Maria; Märker, Michael; Saia, Sergio

2017-04-01

The stock of organic carbon in the soil (SOC) is an indicator of soil ability to support agro-ecosystems productivity and resilience to environmental changes (Schillaci et al. 2016; 2017). In addition, SOC stock change through space and especially time is a valuable indicator of the soil ability to sequester CO2 from the atmosphere and thus its potential to reduce the greenhouse gas effect. In the present work, we mapped (1-km resolution) the space-time variation of the SOC stock after 15 years (1993 to 2008) in a semi-arid Mediterranean area (25,286 km2) after modelling SOC concentration (0-0.4 m depth) with boosted regression trees (BRT) and computing the SOC stock after the application of the bulk density maps of ISRIC (soilgrid.com, Hengl et al., 2014). The area under study (Sicily, south of Italy) has a plenty of contrasting environments, with changing ecosystems, soils, and microclimatic regions. The BRT procedure was run with a set of 25 predictors per year, including land use, soil traits, morphometric indicators and remote sensing covariates (derived from Landsat5 data). The BRT output consisted of a high pseudo-R2(=0.71 for 1993 and 0.63 for 2008) of the SOC concentration, low uncertainty (standard deviation doi:10.1016/j.geoderma.2016.10.

The McLean-Watson line strength formula and its implementation

International Nuclear Information System (INIS)

Hey, J D

2009-01-01

We consider the application of the line strength formula recently derived by Watson (2006 J. Phys. B: At. Mol. Opt. Phys. 39 L291) to transitions between states of high principal quantum number in hydrogenic atoms and ions (Rydberg-Rydberg transitions). Apparent difficulties in the implementation of this formula are overcome by the use of recurrence relations derived by the ladder operator technique of Infeld and Hull (1951 Rev. Mod. Phys. 23 21), and set out in an earlier paper by the present author (2006 J. Phys. B: At. Mol. Opt. Phys. 39 2641). The use of the McLean-Watson formula for such cases is illustrated by the determination of the radiative lifetimes for levels with n ∼ 1000 and comparison of present results with approximate formulae. Interest in this work on the radial matrix elements for large n and n' is related both to measurements of radio recombination lines from tenuous space plasmas, e.g. Stepkin et al (2007 Mon. Not. R. Astron. Soc. 374 852) and to the calculation of Stark broadening for such spectra, e.g. Gigosos et al (2007 Astron. Astrophys. 466 1189), Stambulchik et al (2007 Phys. Rev. E 75 016401) and Stambulchik and Maron (2008 J. Phys. B: At. Mol. Opt. Phys. 41 095703). In addition, we discuss the question of inaccuracy caused by the omission of fine structure in such calculations, and the numerical stability of the recurrence relations used to implement the line strength formulae.

Anàlisi i integració de models de programació paral·lels en SoC Tegra 2

OpenAIRE

Prat Robles, David

2011-01-01

Anàlisi i integració de models de programació paral.lels en SoC Tegra 2 Instal·lació Linux i verificació del funcionament Benchmarks amb altres processadors Escalabilitat de Pthreads VS OpenMP Muntatge del clúster amb MPI Mesures des la xarxa Ethernet Portar StarSs amb NANOS++ a ARMv7 Mesures de consum i temperatura Conclusions i prediccions

Technology-design-manufacturing co-optimization for advanced mobile SoCs

Science.gov (United States)

Yang, Da; Gan, Chock; Chidambaram, P. R.; Nallapadi, Giri; Zhu, John; Song, S. C.; Xu, Jeff; Yeap, Geoffrey

2014-03-01

How to maintain the Moore's Law scaling beyond the 193 immersion resolution limit is the key question semiconductor industry needs to answer in the near future. Process complexity will undoubtfully increase for 14nm node and beyond, which brings both challenges and opportunities for technology development. A vertically integrated design-technologymanufacturing co-optimization flow is desired to better address the complicated issues new process changes bring. In recent years smart mobile wireless devices have been the fastest growing consumer electronics market. Advanced mobile devices such as smartphones are complex systems with the overriding objective of providing the best userexperience value by harnessing all the technology innovations. Most critical system drivers are better system performance/power efficiency, cost effectiveness, and smaller form factors, which, in turns, drive the need of system design and solution with More-than-Moore innovations. Mobile system-on-chips (SoCs) has become the leading driver for semiconductor technology definition and manufacturing. Here we highlight how the co-optimization strategy influenced architecture, device/circuit, process technology and package, in the face of growing process cost/complexity and variability as well as design rule restrictions.

Quantification of SOC and Clay Content Using Visible Near-Infrared Reflectance–Mid-Infrared Reflectance Spectroscopy With Jack-Knifing Partial Least Squares Regression

DEFF Research Database (Denmark)

Peng, Yi; Knadel, Maria; Gislum, René

2014-01-01

A total of 125 soil samples were collected from a Danish field varying in soil texture from sandy to loamy. Visible near-infrared reflectance (Vis-NIR) and mid-infrared reflectance (MIR) spectroscopy combined with chemometric methods were used to predict soil organic carbon (SOC) and clay content...

Análise dos Conceitos Astronômicos Apresentados por Professores de Algumas Escolas Estaduais Brasileiras

Science.gov (United States)

Voelzke, Marcos Rincon; Gonzaga, Edson Pereira

2011-12-01

A razão para o desenvolvimento deste trabalho baseia-se no fato de que muitos professores da Educação Básica (EB) não lidam com conceitos relacionados à astronomia, e quando o fazem eles simplesmente seguem livros didáticos que podem conter erros conceituais. Como é de conhecimento geral a astronomia é um dos conteúdos a serem ensinados na EB fazendo parte dos Parâmetros Curriculares Nacionais e das Propostas Curriculares do Estado de São Paulo, mas é um fato, que vários pesquisadores apontam, a existência de muitos problemas no ensino da astronomia. Com o propósito de minimizar algumas dessas deficiências foi realizado um trabalho de pesquisa com a utilização de questionários pré e pós pesquisa, para tanto foi desenvolvido um Curso de Extensão Universitária para professores da Diretoria de Ensino Regional (DE) que abrange Mauá, Ribeirão Pires e Rio Grande da Serra (no Estado de São Paulo) com os seguintes objetivos: levantar concepções alternativas; subsidiar os professores por meio de palestras, debates e workshops, e verificar o sucesso da aprendizagem após o curso, adotando-se como referência, para a análise dos resultados, os dicionários de Língua Portuguesa (FERREIRA, 2004) e Enciclopédico de Astronomia e Astronáutica (MOURĀO, 1995). Portanto, dezesseis questões foram aplicadas antes e após o curso, assim pode-se verificar após a pesquisa que 100,0% dos professores sabiam os nomes das fases da Lua, 97,0% entenderam que o Sistema Solar é composto por oito planetas, 78,1% foram capazes de explicar como ocorre um eclipse lunar, um eclipse solar e um solstício, 72,7% sabiam como explicar a ocorrência das estações do ano; 64,5% explicaram corretamente a ocorrência do equinócio, 89,7% foram capazes de definir adequadamente o termo cometa; 63,6% definiram asteróide, 54,5% meteoro, 58,1% galáxia, e 42,4% planeta. Os resultados obtidos indicam uma aprendizagem significativa por parte dos participantes.

PSR B0329+54: Statistics of Substructure Discovered within the Scattering Disk on RadioAstron Baselines of up to 235,000 km

Science.gov (United States)

Gwinn, C. R.; Popov, M. V.; Bartel, N.; Andrianov, A. S.; Johnson, M. D.; Joshi, B. C.; Kardashev, N. S.; Karuppusamy, R.; Kovalev, Y. Y.; Kramer, M.; Rudnitskii, A. G.; Safutdinov, E. R.; Shishov, V. I.; Smirnova, T. V.; Soglasnov, V. A.; Steinmassl, S. F.; Zensus, J. A.; Zhuravlev, V. I.

2016-05-01

We discovered fine-scale structure within the scattering disk of PSR B0329+54 in observations with the RadioAstron ground-space radio interferometer. Here we describe this phenomenon, characterize it with averages and correlation functions, and interpret it as the result of decorrelation of the impulse-response function of interstellar scattering between the widely separated antennas. This instrument included the 10 m Space Radio Telescope, the 110 m Green Bank Telescope, the 14 × 25 m Westerbork Synthesis Radio Telescope, and the 64 m Kalyazin Radio Telescope. The observations were performed at 324 MHz on baselines of up to 235,000 km in 2012 November and 2014 January. In the delay domain, on long baselines the interferometric visibility consists of many discrete spikes within a limited range of delays. On short baselines it consists of a sharp spike surrounded by lower spikes. The average envelope of correlations of the visibility function shows two exponential scales, with characteristic delays of {τ }1=4.1+/- 0.3 μ {{s}} and {τ }2=23+/- 3 μ {{s}}, indicating the presence of two scales of scattering in the interstellar medium. These two scales are present in the pulse-broadening function. The longer scale contains 0.38 times the scattered power of the shorter one. We suggest that the longer tail arises from highly scattered paths, possibly from anisotropic scattering or from substructure at large angles.

An Elongin-Cullin-SOCS Box Complex Regulates Stress-Induced Serotonergic Neuromodulation

Directory of Open Access Journals (Sweden)

Xicotencatl Gracida

2017-12-01

Full Text Available Neuromodulatory cells transduce environmental information into long-lasting behavioral responses. However, the mechanisms governing how neuronal cells influence behavioral plasticity are difficult to characterize. Here, we adapted the translating ribosome affinity purification (TRAP approach in C. elegans to profile ribosome-associated mRNAs from three major tissues and the neuromodulatory dopaminergic and serotonergic cells. We identified elc-2, an Elongin C ortholog, specifically expressed in stress-sensing amphid neuron dual ciliated sensory ending (ADF serotonergic sensory neurons, and we found that it plays a role in mediating a long-lasting change in serotonin-dependent feeding behavior induced by heat stress. We demonstrate that ELC-2 and the von Hippel-Lindau protein VHL-1, components of an Elongin-Cullin-SOCS box (ECS E3 ubiquitin ligase, modulate this behavior after experiencing stress. Also, heat stress induces a transient redistribution of ELC-2, becoming more nuclearly enriched. Together, our results demonstrate dynamic regulation of an E3 ligase and a role for an ECS complex in neuromodulation and control of lasting behavioral states.

A Point Mutation in Suppressor of Cytokine Signalling 2 (Socs2 Increases the Susceptibility to Inflammation of the Mammary Gland while Associated with Higher Body Weight and Size and Higher Milk Production in a Sheep Model.

Directory of Open Access Journals (Sweden)

Rachel Rupp

2015-12-01

Full Text Available Mastitis is an infectious disease mainly caused by bacteria invading the mammary gland. Genetic control of susceptibility to mastitis has been widely evidenced in dairy ruminants, but the genetic basis and underlying mechanisms are still largely unknown. We describe the discovery, fine mapping and functional characterization of a genetic variant associated with elevated milk leukocytes count, or SCC, as a proxy for mastitis. After implementing genome-wide association studies, we identified a major QTL associated with SCC on ovine chromosome 3. Fine mapping of the region, using full sequencing with 12X coverage in three animals, provided one strong candidate SNP that mapped to the coding sequence of a highly conserved gene, suppressor of cytokine signalling 2 (Socs2. The frequency of the SNP associated with increased SCC was 21.7% and the Socs2 genotype explained 12% of the variance of the trait. The point mutation induces the p.R96C substitution in the SH2 functional domain of SOCS2 i.e. the binding site of the protein to various ligands, as well-established for the growth hormone receptor GHR. Using surface plasmon resonance we showed that the p.R96C point mutation completely abrogates SOCS2 binding affinity for the phosphopeptide of GHR. Additionally, the size, weight and milk production in p.R96C homozygote sheep, were significantly increased by 24%, 18%, and 4.4%, respectively, when compared to wild type sheep, supporting the view that the point mutation causes a loss of SOCS2 functional activity. Altogether these results provide strong evidence for a causal mutation controlling SCC in sheep and highlight the major role of SOCS2 as a tradeoff between the host's inflammatory response to mammary infections, and body growth and milk production, which are all mediated by the JAK/STAT signaling pathway.

Novel sampling methods for atmospheric semi-volatile organic compounds (SOCs) in a high altitude alpine environment.

Science.gov (United States)

Offenthaler, I; Jakobi, G; Kaiser, A; Kirchner, M; Kräuchi, N; Niedermoser, B; Schramm, K-W; Sedivy, I; Staudinger, M; Thanner, G; Weiss, P; Moche, W

2009-12-01

High- and low-volume active air samplers as well as bulk deposition samplers were developed to sample atmospheric SOCs under the adverse conditions of a mountain environment. Active sampling employed separate filters for different European source regions. Filters were switched depending on daily trajectory forecasts, whose accuracy was evaluated post hoc. The sampling continued on three alpine summits over five periods of four months. The prevailing trajectories varied stronger between sampling periods than between stations. The sampling equipment (active and bulk deposition) proved dependable for operation in a mountain environment, with idle times being mainly due to non-routine manipulations and connectivity.

Untrimmed Low-Power Thermal Sensor for SoC in 22 nm Digital Fabrication Technology

Directory of Open Access Journals (Sweden)

Ro'ee Eitan

2014-12-01

Full Text Available Thermal sensors (TS are essential for achieving optimized performance and reliability in the era of nanoscale microprocessor and system on chip (SoC. Compiling with the low-power and small die area of the mobile computing, the presented TS supports a wide range of sampling frequencies with an optimized power envelope. The TS supports up to 45 K samples/s, low average power consumption, as low as 20 μW, and small core Si area of 0.013 mm2. Advanced circuit techniques are used in order to overcome process variability, ensuring inaccuracy lower than ±2 °C without any calibration. All this makes the presented thermal sensor a cost-effective, low-power solution for 22 nm nanoscale digital process technology.

Implementation of SoC Based Real-Time Electromagnetic Transient Simulator

Directory of Open Access Journals (Sweden)

I. Herrera-Leandro

2017-01-01

Full Text Available Real-time electromagnetic transient simulators are important tools in the design stage of new control and protection systems for power systems. Real-time simulators are used to test and stress new devices under similar conditions that the device will deal with in a real network with the purpose of finding errors and bugs in the design. The computation of an electromagnetic transient is complex and computationally demanding, due to features such as the speed of the phenomenon, the size of the network, and the presence of time variant and nonlinear elements in the network. In this work, the development of a SoC based real-time and also offline electromagnetic transient simulator is presented. In the design, the required performance is met from two sides, (a using a technique to split the power system into smaller subsystems, which allows parallelizing the algorithm, and (b with specialized and parallel hardware designed to boost the solution flow. The results of this work have shown that for the proposed case studies, based on a balanced distribution of the node of subsystems, the proposed approach has decreased the total simulation time by up to 99 times compared with the classical approach running on a single high performance 32-bit embedded processor ARM-Cortex A9.

Amnesic Shellfish Poisoning (ASP)

DEFF Research Database (Denmark)

Ravn, H.

HAB Publ. Ser. vol 1 is a supplement to Chapter 7 Mehtods for Domoic Acid, the Amnesic Shellfish Poisons in the IOC Manual of Harmful Marine Microalgae......HAB Publ. Ser. vol 1 is a supplement to Chapter 7 Mehtods for Domoic Acid, the Amnesic Shellfish Poisons in the IOC Manual of Harmful Marine Microalgae...

Metal–organic frameworks to satisfy gas upgrading demands: fine-tuning the soc-MOF platform for the operative removal of H2S

KAUST Repository

Belmabkhout, Youssef; Pillai, Renjith S.; Alezi, Dalal; Shekhah, Osama; Bhatt, Prashant; Chen, Zhijie; Adil, Karim; Vaesen, Sebastien; De Weireld, Guy; Pang, Maolin; Suetin, Mikhail; Cairns, Amy; Solovyeva, Vera; Shkurenko, Aleksander; El Tall, Omar; Maurin, Guillaume; Eddaoudi, Mohamed

2017-01-01

-framework counter ions (NO3-, Cl- and Br-). In3+-, Fe3+-, Ga3+-and the newly isolated Al(III)-based isostructural soc-MOF were extensively studied and evaluated for the separation-based production of high-quality fuels (i.e., CH4, C3H8 and n-C4H10) and olefins

Algorithm & SoC design for automotive vision systems for smart safe driving system

CERN Document Server

Shin, Hyunchul

2014-01-01

An emerging trend in the automobile industry is its convergence with information technology (IT). Indeed, it has been estimated that almost 90% of new automobile technologies involve IT in some form. Smart driving technologies that improve safety as well as green fuel technologies are quite representative of the convergence between IT and automobiles. The smart driving technologies include three key elements: sensing of driving environments, detection of objects and potential hazards, and the generation of driving control signals including warning signals. Although radar-based systems are primarily used for sensing the driving environments, the camera has gained importance in advanced driver assistance systems(ADAS). This book covers system-on-a-chip (SoC) designs—including both algorithms and hardware—related with image sensing and object detection by using the camera for smart driving systems. It introduces a variety of algorithms such as lens correction, super resolution, image enhancement, and object ...

The collider calamity, publ. by Scientific American

CERN Multimedia

2006-01-01

"For decades, the big guns of American science have been the U.S. Department of Energy's particle collider, which investigate the nature of matter by accelerating subatomic particles and smashing them together." (1 page)

SEMICONDUCTOR INTEGRATED CIRCUITS A 10-bit 200-kS/s SAR ADC IP core for a touch screen SoC

Science.gov (United States)

Xingyuan, Tong; Yintang, Yang; Zhangming, Zhu; Wenfang, Sheng

2010-10-01

Based on a 5 MSBs (most-significant-bits)-plus-5 LSBs (least-significant-bits) C-R hybrid D/A conversion and low-offset pseudo-differential comparison approach, with capacitor array axially symmetric layout topology and resistor string low gradient mismatch placement method, an 8-channel 10-bit 200-kS/s SAR ADC (successive-approximation-register analog-to-digital converter) IP core for a touch screen SoC (system-on-chip) is implemented in a 0.18 μm 1P5M CMOS logic process. Design considerations for the touch screen SAR ADC are included. With a 1.8 V power supply, the DNL (differential non-linearity) and INL (integral non-linearity) of this converter are measured to be about 0.32 LSB and 0.81 LSB respectively. With an input frequency of 91 kHz at 200-kS/s sampling rate, the spurious-free dynamic range and effective-number-of-bits are measured to be 63.2 dB and 9.15 bits respectively, and the power is about 136 μW. This converter occupies an area of about 0.08 mm2. The design results show that it is very suitable for touch screen SoC applications.

Novel sampling methods for atmospheric semi-volatile organic compounds (SOCs) in a high altitude alpine environment

Energy Technology Data Exchange (ETDEWEB)

Offenthaler, I. [Umweltbundesamt GmbH (Austria); Jakobi, G. [Helmholtz Zentrum Muenchen (German Research Centre for Environmental Health) (Germany); Kaiser, A. [ZAMG-Zentralanstalt fuer Meteorologie und Geo-dynamik (Austria); Kirchner, M. [Helmholtz Zentrum Muenchen (German Research Centre for Environmental Health) (Germany); Kraeuchi, N. [WSL-Swiss Federal Institute for Forest, Snow and Landscape Research (Switzerland); Niedermoser, B. [ZAMG-Zentralanstalt fuer Meteorologie und Geo-dynamik (Austria); Schramm, K.-W. [Helmholtz Zentrum Muenchen (German Research Centre for Environmental Health) (Germany); Sedivy, I. [WSL-Swiss Federal Institute for Forest, Snow and Landscape Research (Switzerland); Staudinger, M. [ZAMG-Zentralanstalt fuer Meteorologie und Geo-dynamik (Austria); Thanner, G.; Weiss, P. [Umweltbundesamt GmbH (Austria); Moche, W., E-mail: wolfgang.moche@umweltbundesamt.a [Umweltbundesamt GmbH (Austria)

2009-12-15

High- and low-volume active air samplers as well as bulk deposition samplers were developed to sample atmospheric SOCs under the adverse conditions of a mountain environment. Active sampling employed separate filters for different European source regions. Filters were switched depending on daily trajectory forecasts, whose accuracy was evaluated post hoc. The sampling continued on three alpine summits over five periods of four months. The prevailing trajectories varied stronger between sampling periods than between stations. The sampling equipment (active and bulk deposition) proved dependable for operation in a mountain environment, with idle times being mainly due to non-routine manipulations and connectivity. - Equipment for direction-specific air sampling and bulk deposition sampling in mountains was developed and tested.

Understanding Hydrogen Sorption in In- soc -MOF: A Charged Metal-Organic Framework with Open-Metal Sites, Narrow Channels, and Counterions

KAUST Repository

Pham, Tony

2015-03-04

© 2015 American Chemical Society. Grand canonical Monte Carlo (GCMC) simulations of hydrogen sorption were performed in In-soc-MOF, a charged metal-organic framework (MOF) that contains In3O trimers coordinated to 5,5′-azobis(1,3-benzenedicarboxylate) linkers. The MOF contains nitrate counterions that are located in carcerand-like capsules of the framework. This MOF was shown to have a high hydrogen uptake at 77 K and 1.0 atm. The simulations were performed with a potential that includes explicit many-body polarization interactions, which were important for modeling gas sorption in a charged/polar MOF such as In-soc-MOF. The simulated hydrogen sorption isotherms were in good agreement with experiment in this challenging platform for modeling. The simulations predict a high initial isosteric heat of adsorption, Qst, value of about 8.5 kJ mol^-1, which is in contrast to the experimental value of 6.5 kJ mol^-1 for all loadings. The difference in the Qst behavior between experiment and simulation is attributed to the fact that, in experimental measurements, the sorbate molecules cannot access the isolated cages containing the nitrate ions, the most energetically favorable site in the MOF, at low pressures due to an observed diffusion barrier. In contrast, the simulations were able to capture the sorption of hydrogen onto the nitrate ions at low loading due to the equilibrium nature of GCMC simulations. The experimental Qst values were reproduced in simulation by blocking access to all of the nitrate ions in the MOF. Furthermore, at 77 K, the sorbed hydrogen molecules were reminiscent of a dense fluid in In-soc-MOF starting at approximately 5.0 atm, and this was verified by monitoring the isothermal compressibility, βT, values. The favorable sites for hydrogen sorption were identified from the polarization distribution as the nitrate ions, the In3O trimers, and the azobenzene nitrogen atoms. Lastly, the two-dimensional quantum rotational levels

Pharmacogenetics of efficacy and safety of HCV treatment in HCV-HIV coinfected patients: significant associations with IL28B and SOCS3 gene variants.

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Francesc Vidal

Full Text Available This was a safety and efficacy pharmacogenetic study of a previously performed randomized trial which compared the effectiveness of treatment of hepatitis C virus infection with pegylated interferon alpha (pegIFNα 2a vs. 2b, both with ribavirin, for 48 weeks, in HCV-HIV coinfected patients.The study groups were made of 99 patients (efficacy pharmacogenetic substudy and of 114 patients (safety pharmacogenetic substudy. Polymorphisms in the following candidate genes IL28B, IL6, IL10, TNFα, IFNγ, CCL5, MxA, OAS1, SOCS3, CTLA4 and ITPA were assessed. Genotyping was carried out using Sequenom iPLEX-Gold, a single-base extension polymerase chain reaction. Efficacy end-points assessed were: rapid, early and sustained virological response (RVR, EVR and SVR, respectively. Safety end-points assessed were: anemia, neutropenia, thrombocytopenia, flu-like syndrome, gastrointestinal disturbances and depression. Chi square test, Student's T test, Mann-Whitney U test and logistic regression were used for statistic analyses.As efficacy is concerned, IL28B and CTLA4 gene polymorphisms were associated with RVR (p<0.05 for both comparisons. Nevertheless, only polymorphism in the IL28B gene was associated with SVR (p = 0.004. In the multivariate analysis, the only gene independently associated with SVR was IL28B (OR 2.61, 95%CI 1.2-5.6, p = 0.01. With respect to safety, there were no significant associations between flu-like syndrome or depression and the genetic variants studied. Gastrointestinal disturbances were associated with ITPA gene polymorphism (p = 0.04. Anemia was associated with OAS1 and CTLA4 gene polymorphisms (p = 0.049 and p = 0.045, respectively, neutropenia and thromobocytopenia were associated with SOCS3 gene polymorphism (p = 0.02 and p = 0.002, respectively. In the multivariate analysis, the associations of the SOCS3 gene polymorphism with neutropenia (OR 0.26, 95%CI 0.09-0.75, p = 0.01 and thrombocytopenia (OR

Tectonic and metamorphic discontinuities in the Greater Himalayan Sequence in Central Himalaya: in-sequence shearing by accretion from the Indian plate

Science.gov (United States)

Carosi, Rodolfo

2016-04-01

. Geol. Soc. London Sp. Publ., 268, 1-23. Carosi R., Montomoli C., Rubatto D. & Visonà D. 2010. Tectonics, 29, TC4029. Iaccarino S., Montomoli C., Carosi R., Massonne H-J., Langone A., Visonà D. 2015. Lithos, 231, 103-121. Montomoli C., Iaccarino S., Carosi R., Langone A. & Visonà D. 2013. Tectonophysics 608, 1349-1370, doi:10.1016/j.tecto.2013.06.006. Montomoli C., Carosi R., Iaccarino S. 2015. Geol. Soc. London Sp. Publ., 412, 25-41.

Paeoniflorin Suppressed High Glucose-Induced Retinal Microglia MMP-9 Expression and Inflammatory Response via Inhibition of TLR4/NF-κB Pathway Through Upregulation of SOCS3 in Diabetic Retinopathy.

Science.gov (United States)

Zhu, Su-Hua; Liu, Bing-Qian; Hao, Mao-Juan; Fan, Yi-Xin; Qian, Cheng; Teng, Peng; Zhou, Xiao-Wei; Hu, Liang; Liu, Wen-Tao; Yuan, Zhi-Lan; Li, Qing-Ping

2017-10-01

Diabetic retinopathy (DR) is a serious-threatening complication of diabetes and urgently needed to be treated. Evidence has accumulated indicating that microglia inflammation within the retina plays a critical role in DR. Microglial matrix metalloproteinase 9 (MMP-9) has an important role in the destruction of the integrity of the blood-retinal barrier (BRB) associated with the development of DR. MMP-9 was also considered important for regulating inflammatory responses. Paeoniflorin, a monoterpene glucoside, has a potent immunomodulatory effect on microglia. We hypothesized that paeoniflorin could significantly suppress microglial MMP-9 activation induced by high glucose and further relieve DR. BV2 cells were used to investigate the effects and mechanism of paeoniflorin. The activation of MMP-9 was measured by gelatin zymography. Cell signaling was measured by western blot assay and immunofluorescence assay. High glucose increased the activation of MMP-9 in BV2 cells, which was abolished by HMGB1, TLR4, p38 MAPK, and NF-κB inhibition. Phosphorylation of p38 MAPK induced by high glucose was decreased by TLR4 inhibition in BV2 cells. Paeoniflorin induced suppressor of cytokine signaling 3 (SOCS3) expression and reduced MMP-9 activation in BV2 cells. The effect of paeoniflorin on SOCS3 was abolished by the TLR4 inhibitor. In streptozotocin (STZ)-induced diabetes mice, paeoniflorin induced SOCS3 expression and reduced MMP-9 activation. Paeoniflorin suppressed STZ-induced IBA-1 and IL-1β expression and decreased STZ-induced high blood glucose level. In conclusion, paeoniflorin suppressed high glucose-induced retinal microglia MMP-9 expression and inflammatory response via inhibition of the TLR4/NF-κB pathway through upregulation of SOCS3 in diabetic retinopathy.

Deciphering the embedded wave in Saturn's Maxwell ringlet

Science.gov (United States)

French, Richard G.; Nicholson, Philip D.; Hedman, Mathew M.; Hahn, Joseph M.; McGhee-French, Colleen A.; Colwell, Joshua E.; Marouf, Essam A.; Rappaport, Nicole J.

2016-11-01

The eccentric Maxwell ringlet in Saturn's C ring is home to a prominent wavelike structure that varies strongly and systematically with true anomaly, as revealed by nearly a decade of high-SNR Cassini occultation observations. Using a simple linear "accordion" model to compensate for the compression and expansion of the ringlet and the wave, we derive a mean optical depth profile for the ringlet and a set of rescaled, background-subtracted radial wave profiles. We use wavelet analysis to identify the wave as a 2-armed trailing spiral, consistent with a density wave driven by an m = 2 outer Lindblad resonance (OLR), with a pattern speed Ωp = 1769.17° d-1 and a corresponding resonance radius ares = 87530.0 km. Estimates of the surface mass density of the Maxwell ringlet range from a mean value of 11g cm-2 derived from the self-gravity model to 5 - 12gcm-2 , as inferred from the wave's phase profile and a theoretical dispersion relation. The corresponding opacity is about 0.12 cm2 g-1, comparable to several plateaus in the outer C ring (Hedman, M.N., Nicholson, P.D. [2014]. Mont. Not. Roy. Astron. Soc. 444, 1369-1388). A linear density wave model using the derived wave phase profile nicely matches the wave's amplitude, wavelength, and phase in most of our observations, confirming the accuracy of the pattern speed and demonstrating the wave's coherence over a period of 8 years. However, the linear model fails to reproduce the narrow, spike-like structures that are prominent in the observed optical depth profiles. Using a symplectic N-body streamline-based dynamical code (Hahn, J.M., Spitale, J.N. [2013]. Astrophys. J. 772, 122), we simulate analogs of the Maxwell ringlet, modeled as an eccentric ringlet with an embedded wave driven by a fictitious satellite with an OLR located within the ring. The simulations reproduce many of the features of the actual observations, including strongly asymmetric peaks and troughs in the inward-propagating density wave. We argue that

Lipopolysaccharide (LPS) stimulates adipokine and socs3 gene expression in mouse brain and pituitary gland in vivo, and in N-1 hypothalamic neurons in vitro.

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Brown, Russell; Imran, Syed A; Wilkinson, Michael

2009-04-30

Adipokines that modulate metabolic and inflammatory responses, such as resistin (rstn) and fasting-induced adipose factor (fiaf), are also expressed in mouse brain and pituitary gland. Since lipopolysaccharide (LPS)-induced endotoxinemia provokes an anorectic response via a hypothalamic-dependent mechanism we hypothesized that LPS would also modify hypothalamic adipokine expression. Challenging male CD-1 mice with LPS (5 mg/kg; s.c.) significantly reduced bodyweight (24 h) and realtime RT-PCR revealed time- and tissue-dependent increases in rstn, fiaf and suppressor of cytokine signaling-3 (socs-3) mRNA in hypothalamic, pituitary, cortical and adipose tissues. Gene expression was rapidly increased (3-6 h) in the hypothalamus and pituitary, but returned to normal within 24 h. In contrast, with the exception of rstn in fat, the expression of target genes remained elevated in cortex and visceral fat at 24 h post-injection. In order to more specifically examine the hypothalamic response to LPS we investigated its effects directly on N-1 hypothalamic neurons in vitro. LPS (25 microg/mL; 3 h) had no effect on rstn mRNA, but significantly stimulated fiaf and socs-3 expression. Although various toll-like receptor 4 (TLR4) antagonists (parthenolide, PD098059, and SB202190) did not prevent the LPS-induced increases in fiaf and socs-3, they did partially attenuate its stimulatory effects. We conclude that LPS treatment increases the expression of central, and possibly neuronal, adipokine genes which may influence local tissue repair and function, but could also have downstream consequences on the hypothalamic control of appetite and energy metabolism following an inflammatory insult.

Black swans, power laws, and dragon-kings: Earthquakes, volcanic eruptions, landslides, wildfires, floods, and SOC models

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Sachs, M. K.; Yoder, M. R.; Turcotte, D. L.; Rundle, J. B.; Malamud, B. D.

2012-05-01

Extreme events that change global society have been characterized as black swans. The frequency-size distributions of many natural phenomena are often well approximated by power-law (fractal) distributions. An important question is whether the probability of extreme events can be estimated by extrapolating the power-law distributions. Events that exceed these extrapolations have been characterized as dragon-kings. In this paper we consider extreme events for earthquakes, volcanic eruptions, wildfires, landslides and floods. We also consider the extreme event behavior of three models that exhibit self-organized criticality (SOC): the slider-block, forest-fire, and sand-pile models. Since extrapolations using power-laws are widely used in probabilistic hazard assessment, the occurrence of dragon-king events have important practical implications.

Sticker-type ECG/PPG concurrent monitoring system hybrid integration of CMOS SoC and organic sensor device.

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Yongsu Lee; Hyeonwoo Lee; Seunghyup Yoo; Hoi-Jun Yoo

2016-08-01

The sticker-type sensor system is proposed targeting ECG/PPG concurrent monitoring for cardiovascular diseases. The stickers are composed of two types: Hub and Sensor-node (SN) sticker. Low-power CMOS SoC for measuring ECG and PPG signal is hybrid integrated with organic light emitting diodes (OLEDs) and organic photo detector (OPD). The sticker has only 2g weight and only consumes 141μW. The optical calibration loop is adopted for maintaining SNR of PPG signal higher than 30dB. The pulse arrival time (PAT) and SpO2 value can be extracted from various body parts and verified comparing with the reference device from 20 people in-vivo experiments.

Overexpression of an orchid (Dendrobium nobile SOC1/TM3-like ortholog, DnAGL19, in Arabidopsis regulates HOS1-FT expression

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Xiao-ru eLiu

2016-02-01

Full Text Available Flowering in the appropriate season is critical for successful reproduction in angiosperms. The orchid species, Dendrobium nobile, requires vernalization to achieve flowering in the spring, but the underlying regulatory network has not been identified to date. The MADS-box transcription factor DnAGL19 was previously identified in a study of low-temperature treated D. nobile buds and was suggested to regulate vernalization-induced flowering. In this study, phylogenetic analysis of DnAGL9 and the MADS-box containing proteins showed that DnAGL19 is phylogenetically closely related to the SOC1-like protein from orchid Dendrobium Chao Parya Smile, DOSOC1. The orchid clade closed to but is not included into the SOC1-1/TM3 clades associated with either eudicots or monocots, suggesting that DnAGL19 is an SOC1-1/TM3-like ortholog. DnAGL19 was found to be highly expressed in pseudobulbs, leaves, roots and axillary buds but rarely in flowers, and to be substantially upregulated in axillary buds by prolonged low-temperature treatments. Overexpression of DnAGL19 in Arabidopsis thaliana resulted in a small but significantly reduced time to bolting, suggesting that flowering time was slightly accelerated under normal growth conditions. Consistent with this, the A. thaliana APETELA1 (AP1 gene was expressed at an earlier stage in transgenic lines than in wild type plants, while the FLOWERING LOCUS T (FT gene was suppressed, suggesting that altered regulations on these transcription factors caused the weak promotion of flowering. HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENE 1 (HOS1 was slightly activated under the same conditions, suggesting that the HOS1-FT module may be involved in the DnAGL19-related network. Under vernalization conditions, FT expression was significantly upregulated, whereas HOS1 expression in the transgenic A. thaliana has a level similar to that in wild type. Taken together, these results suggest that DnAGL19 controls the action of the

Mediciones de irradiancia solar y capa de ozono durante el eclipse de Sol de 1994 en el Observatorio Astronómico de Rosario, Argentina

Science.gov (United States)

Piacentini, R. D.; Micheletti, M. I.

We show results of measurements made during the Sun's eclipse of November 3, 1994, in Observatorio Astronómico de Rosario (32o 57' S, 60o 37' W, 25 m a.s.l.). The eclipse begin at 8:41 local hour, reached its maximum with 77% of the surface covered at 9:51 and finished at 11:04. The direct solar irradiance of 300 nm and 313 nm were able to be measured, due to the fact that during the whole period the sky remained completed uncovered (zero percent cloudiness). The measurements were made with the portable ozonometer developed by Tocho and co-workers. They show the characterictic decrease due to the occultation of the source, which is approximately proportional to the surface's diminution. When crossing the earth's atmosphere to arrive to the observation point, these irradiances are affected mainly by the ozone layer, specially the irradiance at lower wavelength, what let it to determine by comparison the thickness of this layer. The total ozone thickness distributed between the troposphere and the stratosphere shows an oscillation, whose amplitude, since the occurence of the maximum of occulation, has a mean value of 4%, and whose period is of approximately 2100 seconds, being both numbers considerably larger than the ones registred by Mims III y Mims (Geophysical Research Letters, 20, 367, 1993) during the eclipse of July 11, 1991 and by Tocho, Da Silva y Rivas (XVIII Quadriennial Ozone Symposiom, Italy, September, 1996) during the same eclipse analyzed in the present work, but observed in Salta. As complementary results, we measured the global irradiance and the ambient temperature during this astronomical event.

A systematic study on factors affecting patient dose, (1)

International Nuclear Information System (INIS)

Otsuka, Akiyoshi; Higashida, Yoshiharu; Utsumi, Hiromoto; Ota, Masaji; Nakanishi, Takashi

1979-01-01

In the study of possible reduction in irradiation dose to patients during medical treatments, the following two methods can be considered: (1) To obtain absorbed doses for each part of a body in diagnostic X-ray examinations. (2) To obtain data on factors such as the tube voltage which may affect patient dose. There are a number of reports both at home and abroad concerning the above (1), but very few reports are available concerning the above (2). Moreover, most of them are on fragmentary aspects of each factor and no systematic reports have been made. For this reason, we have taken up, as factors affecting the patient dose, the field size, the tube voltage, and by checking them again, we wanted to obtain some systematic data. Our aim has been fully attained by conducting an experiment. In the ICRP's Publ. 26 issued last year, the idea of the critical organ which had not been fully elucidated in the Publ. 9 was abandoned. As a result, assessment of the irradiation doses has become more rational and the total risk for an individual was obtained. In Japan, the idea proposed in the Publ. 9 is adopted. Therefore, in this paper, we will raise some questions regarding the assessment of the irradiation doses, pointing out at the same time the rationality of the idea put forward in Publ. 26. (author)

Diseño de una Red de Sensores Inalámbrica para un Sistema de Observación Costero (SOC)

OpenAIRE

Albaladejo Pérez, Cristina

2009-01-01

Las Redes de Sensores Inalámbricas (Wireless Sensor Network, WSN) son un conjunto de dispositivos que permiten una comunicación sin cables, interconectados entre sí a través de una red inalámbrica y a su vez conectados a un sistema central en el que se recopilará la información recogida por cada uno de los sensores. En el presente Trabajo Fin de Máster se persigue realizar un estudio teórico sobre el diseño de una WSN para un Sistema de Observación Costero (SOC) cuyo objetivo es la monitoriz...

Ankyrin repeat and SOCS box containing protein 4 (Asb-4 colocalizes with insulin receptor substrate 4 (IRS4 in the hypothalamic neurons and mediates IRS4 degradation

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Xia Zefeng

2011-09-01

Full Text Available Abstract Background The arcuate nucleus of the hypothalamus regulates food intake. Ankyrin repeat and SOCS box containing protein 4 (Asb-4 is expressed in neuropeptide Y and proopiomelanocortin (POMC neurons in the arcuate nucleus, target neurons in the regulation of food intake and metabolism by insulin and leptin. However, the target protein(s of Asb-4 in these neurons remains unknown. Insulin receptor substrate 4 (IRS4 is an adaptor molecule involved in the signal transduction by both insulin and leptin. In the present study we examined the colocalization and interaction of Asb-4 with IRS4 and the involvement of Asb-4 in insulin signaling. Results In situ hybridization showed that the expression pattern of Asb-4 was consistent with that of IRS4 in the rat brain. Double in situ hybridization showed that IRS4 colocalized with Asb-4, and both Asb-4 and IRS4 mRNA were expressed in proopiomelanocortin (POMC and neuropeptide Y (NPY neurons within the arcuate nucleus of the hypothalamus. In HEK293 cells co-transfected with Myc-tagged Asb-4 and Flag-tagged IRS4, Asb-4 co-immunoprecipitated with IRS4; In these cells endogenous IRS4 also co-immunoprecipitated with transfected Myc-Asb-4; Furthermore, Asb-4 co-immunoprecipitated with IRS4 in rat hypothalamic extracts. In HEK293 cells over expression of Asb-4 decreased IRS4 protein levels and deletion of the SOCS box abolished this effect. Asb-4 increased the ubiquitination of IRS4; Deletion of SOCS box abolished this effect. Expression of Asb-4 decreased both basal and insulin-stimulated phosphorylation of AKT at Thr308. Conclusions These data demonstrated that Asb-4 co-localizes and interacts with IRS4 in hypothalamic neurons. The interaction of Asb-4 with IRS4 in cell lines mediates the degradation of IRS4 and decreases insulin signaling.

Sobre os céus e as marés do Pacífico: as observações astronômicas do jesuíta Nicolás Mascardi (Chile, século XVII

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Eliane Cristina Deckmann Fleck

2014-12-01

Full Text Available A atuação da Companhia de Jesus na América espanhola e portuguesa constitui-se em tema de várias investigações e obras, nas quais merece destaque a dedicação de seus religiosos ao ensino e à catequese. Alguns membros da Ordem, no entanto, se dedicaram, também, a observações de fenômenos naturais, da fauna e da flora nativas e, ainda, a aspectos da geografia dos territórios em que atuaram, legando-nos uma série de estudos informados através de cartas, relatórios ou obras. Nosso propósito neste artigo é o de apresentar e analisar os registros que o padre jesuíta italiano Nicolás Mascardi fez de suas observações astronômicas e, em especial, do estudo que realizou sobre as marés do arquipélago de Chiloé durante os anos em que atuou na então Vice-Província Jesuítica do Chile, no século XVII.

Implementation of a wireless ECG acquisition SoC for IEEE 802.15.4 (ZigBee) applications.

Science.gov (United States)

Wang, Liang-Hung; Chen, Tsung-Yen; Lin, Kuang-Hao; Fang, Qiang; Lee, Shuenn-Yuh

2015-01-01

This paper presents a wireless biosignal acquisition system-on-a-chip (WBSA-SoC) specialized for electrocardiogram (ECG) monitoring. The proposed system consists of three subsystems, namely, 1) the ECG acquisition node, 2) the protocol for standard IEEE 802.15.4 ZigBee system, and 3) the RF transmitter circuits. The ZigBee protocol is adopted for wireless communication to achieve high integration, applicability, and portability. A fully integrated CMOS RF front end containing a quadrature voltage-controlled oscillator and a 2.4-GHz low-IF (i.e., zero-IF) transmitter is employed to transmit ECG signals through wireless communication. The low-power WBSA-SoC is implemented by the TSMC 0.18-μm standard CMOS process. An ARM-based displayer with FPGA demodulation and an RF receiver with analog-to-digital mixed-mode circuits are constructed as verification platform to demonstrate the wireless ECG acquisition system. Measurement results on the human body show that the proposed SoC can effectively acquire ECG signals.

60 GHz system-on-chip (SoC) with built-in memory and an on-chip antenna

KAUST Repository

Ghaffar, Farhan A.

2014-04-01

A novel 60 GHz transmitter SoC with an on-chip antenna and integrated memory in CMOS 65 nm technology is presented in this paper. This highly integrated transmitter design can support a data rate of 2 GBPS with a transmission range of 1 m. The transmitter consists of a fundamental frequency 60 GHz PLL which covers the complete ISM band. The modulator following the PLL can support both BPSK and OOK modulation schemes. Both stored data on the integrated memory or directly from an external source can be transmitted. A tapered slot on chip antenna is integrated with the power amplifier to complete the front end of the transmitter design. Size of the complete transmitter with on-chip antenna is only 1.96 mm × 1.96 mm. The core circuits consume less than 100 mW of power. The high data rate capability of the design makes it extremely suitable for bandwidth hungry applications such as unencrypted HD video streaming and transmission.

60 GHz system-on-chip (SoC) with built-in memory and an on-chip antenna

KAUST Repository

Ghaffar, Farhan A.; Arsalan, Muhammad; Cheema, Hammad; Salama, Khaled N.; Shamim, Atif

2014-01-01

A novel 60 GHz transmitter SoC with an on-chip antenna and integrated memory in CMOS 65 nm technology is presented in this paper. This highly integrated transmitter design can support a data rate of 2 GBPS with a transmission range of 1 m. The transmitter consists of a fundamental frequency 60 GHz PLL which covers the complete ISM band. The modulator following the PLL can support both BPSK and OOK modulation schemes. Both stored data on the integrated memory or directly from an external source can be transmitted. A tapered slot on chip antenna is integrated with the power amplifier to complete the front end of the transmitter design. Size of the complete transmitter with on-chip antenna is only 1.96 mm × 1.96 mm. The core circuits consume less than 100 mW of power. The high data rate capability of the design makes it extremely suitable for bandwidth hungry applications such as unencrypted HD video streaming and transmission.

Dynamic Voltage-Frequency and Workload Joint Scaling Power Management for Energy Harvesting Multi-Core WSN Node SoC

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Xiangyu Li

2017-02-01

Full Text Available This paper proposes a scheduling and power management solution for energy harvesting heterogeneous multi-core WSN node SoC such that the system continues to operate perennially and uses the harvested energy efficiently. The solution consists of a heterogeneous multi-core system oriented task scheduling algorithm and a low-complexity dynamic workload scaling and configuration optimization algorithm suitable for light-weight platforms. Moreover, considering the power consumption of most WSN applications have the characteristic of data dependent behavior, we introduce branches handling mechanism into the solution as well. The experimental result shows that the proposed algorithm can operate in real-time on a lightweight embedded processor (MSP430, and that it can make a system do more valuable works and make more than 99.9% use of the power budget.

Postlingual deaf speech and the role of audition in speech production: comments on Waldstein's paper [R.S. Waldstein, J. Acoust. Soc. Am. 88, 2099-2114 (1990)].

Science.gov (United States)

Sapir, S; Canter, G J

1991-09-01

Using acoustic analysis techniques, Waldstein [J. Acoust. Soc. Am. 88, 2099-2114 (1990] reported abnormal speech findings in postlingual deaf speakers. She interpreted her findings to suggest that auditory feedback is important in motor speech control. However, it is argued here that Waldstein's interpretation may be unwarranted without addressing the possibility of neurologic deficits (e.g., dysarthria) as confounding (or even primary) causes of the abnormal speech in her subjects.

Preliminary Electrochemical Characterization of Anode Supported Solid Oxide Cell (AS-SOC) Produced in the Institute of Power Engineering Operated in Electrolysis Mode (SOEC)

Science.gov (United States)

Kupecki, Jakub; Motyliński, Konrad; Skrzypkiewicz, Marek; Wierzbicki, Michał; Naumovich, Yevgeniy

2017-12-01

The article discusses the operation of solid oxide electrochemical cells (SOC) developed in the Institute of Power Engineering as prospective key components of power-to-gas systems. The fundamentals of the solid oxide cells operated as fuel cells (SOFC - solid oxide fuel cells) and electrolysers (SOEC - solid oxide fuel cells) are given. The experimental technique used for electrochemical characterization of cells is presented. The results obtained for planar cell with anodic support are given and discussed. Based on the results, the applicability of the cells in power-to-gas systems (P2G) is evaluated.

Soc para la identificación de variaciones morfológicas del eritrocito

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Danelia Matos Molina

2011-03-01

Full Text Available Normal 0 21 false false false MicrosoftInternetExplorer4 st1:*{behavior:url(#ieooui } /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Tabla normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} En el presente se expone el diseño e implementación de un Sistema on Chip apropiado para el procesamiento de señales e imágenes. Este sistema puede representar parte importante en dispositivos médicos de apoyo en el diagnóstico de ciertas  enfermedades donde ocurran variaciones morfológicas en los eritrocitos, como es el caso de la Siklemia. El diseño está basado en un SoC de Plasma y un procesador MIPS Lite, se ha añadido además un núcleo FFT para el mejoramiento de los cálculos de la Transformada discreta de Fourier. Igualmente ha sido desarrollado un programa que calcula dada una imagen, la FFT de los bordes de los eritrocitos presentes.

A Plastid Protein That Evolved from Ubiquitin and Is Required for Apicoplast Protein Import in Toxoplasma gondii

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Justin D. Fellows

2017-06-01

Full Text Available Apicomplexan parasites cause a variety of important infectious diseases, including malaria, toxoplasma encephalitis, and severe diarrhea due to Cryptosporidium. Most apicomplexans depend on an organelle called the apicoplast which is derived from a red algal endosymbiont. The apicoplast is essential for the parasite as the compartment of fatty acid, heme, and isoprenoid biosynthesis. The majority of the approximate 500 apicoplast proteins are nucleus encoded and have to be imported across the four membranes that surround the apicoplast. Import across the second outermost membrane of the apicoplast, the periplastid membrane, depends on an apicoplast-specific endoplasmic reticulum-associated protein degradation (ERAD complex and on enzymes of the associated ubiquitination cascade. However, identification of an apicoplast ubiquitin associated with this machinery has long been elusive. Here we identify a plastid ubiquitin-like protein (PUBL, an apicoplast protein that is derived from a ubiquitin ancestor but that has significantly changed in its primary sequence. PUBL is distinct from known ubiquitin-like proteins, and phylogenomic analyses suggest a clade specific to apicomplexans. We demonstrate that PUBL and the AAA ATPase CDC48AP both act to translocate apicoplast proteins across the periplastid membrane during protein import. Conditional null mutants and genetic complementation show that both proteins are critical for this process and for parasite survival. PUBL residues homologous to those that are required for ubiquitin conjugation onto target proteins are essential for this function, while those required for polyubiquitination and preprotein processing are dispensable. Our experiments provide a mechanistic understanding of the molecular machinery that drives protein import across the membranes of the apicoplast.

List of Registered Participants

Indian Academy of Sciences (India)

user1

Heald, George. ASTRON heald@astron.nl. Hoeft, Matthias. Thueringer Landessternwarte Tautenburg hoeft@tls-tautenburg.de. Ishwara Chandra, C. H.. NCRA-TIFR ishwar@ncra.tifr.res.in. Johnston-Hollitt, Melanie. School of Chemical & Physical Sciences. Melanie.Johnston-Hollitt@vuw.ac.nz. Jacob, Joe. Newman College.

Noise and Spurious Tones Management Techniques for Multi-GHz RF-CMOS Frequency Synthesizers Operating in Large Mixed Analog-Digital SOCs

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Maxim Adrian

2006-01-01

Full Text Available This paper presents circuit techniques and power supply partitioning, filtering, and regulation methods aimed at reducing the phase noise and spurious tones in frequency synthesizers operating in large mixed analog-digital system-on-chip (SOC. The different noise and spur coupling mechanisms are presented together with solutions to minimize their impact on the overall PLL phase noise performance. Challenges specific to deep-submicron CMOS integration of multi-GHz PLLs are revealed, while new architectures that address these issues are presented. Layout techniques that help reducing the parasitic noise and spur coupling between digital and analog blocks are described. Combining system-level and circuit-level low noise design methods, low phase noise frequency synthesizers were achieved which are compatible with the demanding nowadays wireless communication standards.

Compilation of nuclear decay data used for dose calculation. Revised data for radionuclides listed in ICRP Publication 38

International Nuclear Information System (INIS)

Endo, Akira; Yamaguchi, Yasuhiro

2001-03-01

New nuclear decay data used for dose calculation have been compiled for 817 radionuclides that are listed in ICRP Publication 38 (Publ. 38) and for 6 additional isomers. The decay data were prepared using decay data sets from the Evaluated Nuclear Structure Data File (ENSDF), the latest version in August 1997. Basic nuclear properties in the decay data sets that are particularly important for calculating energies and intensities of emissions were examined and updated by referring to NUBASE, the database for nuclear and decay properties of nuclides. The reviewed and updated data were half-life, decay mode and its branching ratio, spin and parity of the ground and isomeric states, excitation energy of isomers, and Q value. In addition, possible revisions of partial and incomplete decay data sets were done for their format and syntax errors, level schemes, normalization records, and so on. After that, the decay data sets were processed by EDISTR in order to compute the energies and intensities of α particles, β particles, γ rays, internal conversion electrons, X rays, and Auger electrons emitted in nuclear transformation. For spontaneously fissioning nuclides, the average energies and intensities of neutrons, fission fragments, prompt γ rays, delayed γ rays, and β particles were also calculated. The compiled data were prepared in two different types of format: Publ. 38 and NUCDECAY formats. Comparison of the compiled decay data with those in Publ. 38 was also presented. The decay data will be widely used for internal and external dose calculations in radiation protection and will be beneficial to a future revision of ICRP Publ. 38. (author)

Compilation of nuclear decay data used for dose calculation. Revised data for radionuclides listed in ICRP Publication 38

Energy Technology Data Exchange (ETDEWEB)

Endo, Akira; Yamaguchi, Yasuhiro [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

2001-03-01

New nuclear decay data used for dose calculation have been compiled for 817 radionuclides that are listed in ICRP Publication 38 (Publ. 38) and for 6 additional isomers. The decay data were prepared using decay data sets from the Evaluated Nuclear Structure Data File (ENSDF), the latest version in August 1997. Basic nuclear properties in the decay data sets that are particularly important for calculating energies and intensities of emissions were examined and updated by referring to NUBASE, the database for nuclear and decay properties of nuclides. The reviewed and updated data were half-life, decay mode and its branching ratio, spin and parity of the ground and isomeric states, excitation energy of isomers, and Q value. In addition, possible revisions of partial and incomplete decay data sets were done for their format and syntax errors, level schemes, normalization records, and so on. After that, the decay data sets were processed by EDISTR in order to compute the energies and intensities of {alpha} particles, {beta} particles, {gamma} rays, internal conversion electrons, X rays, and Auger electrons emitted in nuclear transformation. For spontaneously fissioning nuclides, the average energies and intensities of neutrons, fission fragments, prompt {gamma} rays, delayed {gamma} rays, and {beta} particles were also calculated. The compiled data were prepared in two different types of format: Publ. 38 and NUCDECAY formats. Comparison of the compiled decay data with those in Publ. 38 was also presented. The decay data will be widely used for internal and external dose calculations in radiation protection and will be beneficial to a future revision of ICRP Publ. 38. (author)

A method for the densification of ceramic layers, especially ceramic layers within solid oxide cell (SOC) technology, and products obtained by the method

DEFF Research Database (Denmark)

2013-01-01

A ceramic layer, especially for use in solid oxide cell (SOC) technology, is densified in a method comprising (a) providing a multilayer system by depositing the porous ceramic layer, which is to be densified, onto the selected system of ceramic layers on a support, (b) pre-sintering the resulting......(s) in the porous layer surface and (e) performing a thermal treatment at a temperature T2, where T2 > ?1, to obtain densification of and grain growth in the porous layer formed in step (b). The method makes it possible to obtain dense ceramic layers at temperatures, which are compatible with the other materials...... present in a ceramic multilayer system....

Soil Organic Carbon (SOC) distribution in two differents soil types (Podzol and Andosol) under natural forest cover.

Science.gov (United States)

Álvarez-Romero, Marta; Papa, Stefania; Verstraeten, Arne; Cools, Nathalie; Lozano-García, Beatriz; Parras-Alcántara, Luis; Coppola, Elio

2017-04-01

Andosols are young soils that shall know a successive evolution towards pedological types where the dominant pedogenetic processes are more evident. Vegetation and climate influence Andosols evolution to other order of soils. In cold and wet climates or on acid vulcanite under heavy leaching young Andosols could change into Podzols (Van Breemn and Buurman, 1998). Were investigated a Podzol soil (World References Base, 2014) at Zoniën (Belgium), were and an Andosol soil (World References Base, 2014) at Lago Laceno (Avellino, Italy). This study shows the data on the SOC (Soil Organic Carbon) fractionation in two profiles from two natural pine forest soils. Together with the conventional activities of sampling and analysis of soil profile were examined surveys meant to fractionation and characterization of SOC, in particular: Total Organic Carbon (TOC) and Total Extractable Carbon (TEC) soil contents were determined by Italian official method of soil analysis (Mi.P.A.F. (2000)). Different soil C fractions were also determined: Humic Acid Carbon (HAC), Fulvic Acid Carbon (FAC), Not Humic Carbon (NHC) and Humin Carbon (Huc) fractions were obtained by difference. In the whole profile, therefore, were also assayed cellulose and lignin contents. The aim of this work was to compare the distribution of different soil organic components in a podzol and a soil with andic properties. The data show great similarity, among the selected profiles, in the organic components distribution estudied. References: - Mi.P.A.F. - Ministero per le Politiche Agricole e Forestali - Osservatorio Nazionale Pedologico e per la Qualità del Suolo (2000): Metodi Ufficiali di Analisi Chimica del Suolo. In: Franco Angeli (Editor), Collana di metodi analitici per l'agricoltura diretta da Paolo Sequi, n. 1124.2, Milano, Italy. - Van Breemn N. and Buurman P. (1998) Chapter 12 Formation of Andisols. In: Soil formation. Kluwer Ed., Wageningen, The Netherlands, 271-289. -Ussiri D.A.N., Johnson C

Maximum gravitational-wave energy emissible in magnetar flares

Science.gov (United States)

Corsi, Alessandra; Owen, Benjamin J.

2011-05-01

Recent searches of gravitational-wave data raise the question of what maximum gravitational-wave energies could be emitted during gamma-ray flares of highly magnetized neutron stars (magnetars). The highest energies (˜1049erg) predicted so far come from a model [K. Ioka, Mon. Not. R. Astron. Soc.MNRAA40035-8711 327, 639 (2001), http://adsabs.harvard.edu/abs/2001MNRAS.327..639I] in which the internal magnetic field of a magnetar experiences a global reconfiguration, changing the hydromagnetic equilibrium structure of the star and tapping the gravitational potential energy without changing the magnetic potential energy. The largest energies in this model assume very special conditions, including a large change in moment of inertia (which was observed in at most one flare), a very high internal magnetic field, and a very soft equation of state. Here we show that energies of 1048-1049erg are possible under more generic conditions by tapping the magnetic energy, and we note that similar energies may also be available through cracking of exotic solid cores. Current observational limits on gravitational waves from magnetar fundamental modes are just reaching these energies and will beat them in the era of advanced interferometers.

Maximum gravitational-wave energy emissible in magnetar flares

International Nuclear Information System (INIS)

Corsi, Alessandra; Owen, Benjamin J.

2011-01-01

Recent searches of gravitational-wave data raise the question of what maximum gravitational-wave energies could be emitted during gamma-ray flares of highly magnetized neutron stars (magnetars). The highest energies (∼10 49 erg) predicted so far come from a model [K. Ioka, Mon. Not. R. Astron. Soc. 327, 639 (2001), http://adsabs.harvard.edu/abs/2001MNRAS.327..639I] in which the internal magnetic field of a magnetar experiences a global reconfiguration, changing the hydromagnetic equilibrium structure of the star and tapping the gravitational potential energy without changing the magnetic potential energy. The largest energies in this model assume very special conditions, including a large change in moment of inertia (which was observed in at most one flare), a very high internal magnetic field, and a very soft equation of state. Here we show that energies of 10 48 -10 49 erg are possible under more generic conditions by tapping the magnetic energy, and we note that similar energies may also be available through cracking of exotic solid cores. Current observational limits on gravitational waves from magnetar fundamental modes are just reaching these energies and will beat them in the era of advanced interferometers.

On the jets, kinks, and spheromaks formed by a planar magnetized coaxial gun

International Nuclear Information System (INIS)

Hsu, S.C.; Bellan, P.M.

2005-01-01

Measurements of the various plasma configurations produced by a planar magnetized coaxial gun provide insight into the magnetic topology evolution resulting from magnetic helicity injection. Important features of the experiments are a very simple coaxial gun design so that all observed geometrical complexity is due to the intrinsic physical dynamics rather than the source shape and use of a fast multiple-frame digital camera which provides direct imaging of topologically complex shapes and dynamics. Three key experimental findings were obtained: (1) formation of an axial collimated jet [Hsu and Bellan, Mon. Not. R. Astron. Soc. 334, 257 (2002)] that is consistent with a magnetohydrodynamic description of astrophysical jets (2) identification of the kink instability when this jet satisfies the Kruskal-Shafranov limit, and (3) the nonlinear properties of the kink instability providing a conversion of toroidal to poloidal flux as required for spheromak formation by a coaxial magnetized source [Hsu and Bellan, Phys. Rev. Lett. 90, 215002 (2003)]. An interpretation is proposed for how the n=1 central column instability provides flux amplification during spheromak formation and sustainment, and it is shown that jet collimation can occur within one rotation of the background poloidal field

A Hot White Dwarf Luminosity Function from the Sloan Digital Sky Survey

Science.gov (United States)

2009-01-01

Berro, E., Torres, S., & Catalan, S. 2008, ApJ, 682, L109 Ivezic, Z., Lupton, R. H., Schlegel, D., et al. 2004, Astron. Nachrichten , 325, 583...et al. 2002, AJ, 123, 485 Tucker, D., Kent, S., Richmond, M. W., et al. 2006, Astron. Nachrichten , 327, 821 Vennes, S. 1999, ApJ, 525, 995 Vennes, S

Comment on "Relative variance of the mean squared pressure in multimode media: rehabilitating former approaches" [J. Acoust. Soc. Am. 136, 2621-2629 (2014)].

Science.gov (United States)

Davy, John L; Weaver, Richard L

2015-03-01

Models for the statistics of responses in finite reverberant structures, and in particular, for the variance of the mean square pressure in reverberation rooms, have been studied for decades. It is therefore surprising that a recent communication has claimed that the literature has gotten the simplest of such calculations very wrong. Monsef, Cozza, Rodrigues, Cellard, and Durocher [(2014). J. Acoust. Soc. Am. 136, 2621-2629] have derived a modal-based expression for the relative variance that differs significantly from expressions that have been accepted since 1969. This Comment points out that the Monsef formula is clearly incorrect, and then for the interested reader, points out the subtle place where they made their mistake.

NASA's Astronant Family Support Office

Science.gov (United States)

Beven, Gary; Curtis, Kelly D.; Holland, Al W.; Sipes, Walter; VanderArk, Steve

2014-01-01

During the NASA-Mir program of the 1990s and due to the challenges inherent in the International Space Station training schedule and operations tempo, it was clear that a special focus on supporting families was a key to overall mission success for the ISS crewmembers pre-, in- and post-flight. To that end, in January 2001 the first Family Services Coordinator was hired by the Behavioral Health and Performance group at NASA JSC and matrixed from Medical Operations into the Astronaut Office's organization. The initial roles and responsibilities were driven by critical needs, including facilitating family communication during training deployments, providing mission-specific and other relevant trainings for spouses, serving as liaison for families with NASA organizations such as Medical Operations, NASA management and the Astronaut Office, and providing assistance to ensure success of an Astronaut Spouses Group. The role of the Family Support Office (FSO) has modified as the ISS Program matured and the needs of families changed. The FSO is currently an integral part of the Astronaut Office's ISS Operations Branch. It still serves the critical function of providing information to families, as well as being the primary contact for US and international partner families with resources at JSC. Since crews launch and return on Russian vehicles, the FSO has the added responsibility for coordinating with Flight Crew Operations, the families, and their guests for Soyuz launches, landings, and Direct Return to Houston post-flight. This presentation will provide a summary of the family support services provided for astronauts, and how they have changed with the Program and families the FSO serves. Considerations for future FSO services will be discussed briefly as NASA proposes one year missions and beyond ISS missions. Learning Objective: 1) Obtain an understanding of the reasons a Family Support Office was important for NASA. 2) Become familiar with the services provided for astronauts and their families and how they changed with the Program and family needs.

The ZYNQ book embedded processing with the ARM Cortex-A9 on the Xilinx Zynq-7000 all programmable SoC

CERN Document Server

Crockett, Louise H; Enderwitz, Martin A; Stewart, Robert W

2014-01-01

This book is about the Zynq-7000 All Programmable System on Chip, the family of devices from Xilinx that combines an application-grade ARM Cortex-A9 processor with traditional FPGA logic fabric. Catering for both new and experienced readers, it covers fundamental issues in an accessible way, starting with a clear overview of the device architecture, and an introduction to the design tools and processes for developing a Zynq SoC. Later chapters progress to more advanced topics such as embedded systems development, IP block design and operating systems. Maintaining a 'real-world' perspective, the book also compares Zynq with other device alternatives, and considers end-user applications. The Zynq Book is accompanied by a set of practical tutorials hosted on a companion website. These tutorials will guide the reader through first steps with Zynq, following on to a complete, audio-based embedded systems design.

patrika 54.pdf | Patrika | publ...ns | Indian Academy of Sciences

Indian Academy of Sciences (India)

Ethical Guidelines and Procedures document. Posted on 17 January 2017. A revised version of the document 'Scientific Values: Ethical Guidelines and Procedures' has been produced by the Academy's Panel on Scientific Values. For more details, see the Academy Committee on Scientific Values page.

Papel de la proteína supresora de la señalización por citocinas-3 (SOCS 3 en la resistencia a la hormona de crecimiento inducida por malnutrición.

Directory of Open Access Journals (Sweden)

Adriana Umaña

2003-09-01

Full Text Available La nutrición es un regulador importante de las acciones de la hormona de crecimiento (GH. Se ha demostrado que el déficit de nutrientes induce un estado de resistencia a la hormona, en el cual están involucrados, entre otros factores, alteraciones post-receptor en la vía de señalización, pero se desconocen los mecanismos responsables. En este trabajo se investigó la participación de algunos miembros de la familia de proteínas supresoras de la señalización por citocinas (SOCS en la resistencia causada por malnutrición, que inhibe la activación de la señalización a través de Janus cinasa 2/transductor de señal y activador de la transcripción 5 (JK2/STAT5. Se estudiaron los cambios en la expresión génica del receptor de GH (RGH, IGF-I y SOCS3 en el hígado de ratas alimentadas con una dieta baja en proteína (8% y estimuladas con GH. La restricción en el consumo de proteína disminuyó significativamente (p

Plant regeneration and ploidy level stability in Carica papaya ...

African Journals Online (AJOL)

Usuario

2013-04-11

Apr 11, 2013 ... these outcomes, the tissue culture protocol presented here may be considered a successful .... response was strongly influenced by climatic seasonality, .... Indian J. Biotechnol. ... PhD Thesis, Universiti Sains Malaysia Publ.

Race to the snow: Photography and the exploration of Dutch New Guinea, 1907-1936

NARCIS (Netherlands)

Ballard, C.; Vink, S.A.; Ploeg, A.

2001-01-01

Publ. on the occasion of the exhibition 'Race to the snow' at the Royal Tropical Institute, Amsterdam (4 October 2001-31 January 2002), the Erasmushuis, Jakarta (spring 2002) and Timika, Irian Jaya (summer 2002)

Use of LabSOCS for determination of specific concentrations of 40K, 238U and 232Th in fertilizer samples

International Nuclear Information System (INIS)

Garcez, Ricardo Washington Dutra; Lopes, Jose Marques; Silva, Ademir Xavier da; Domingues, Alessandro Mariano; Lima, Marco Frota

2015-01-01

Use of fertilizer is an established practice worldwide to promote agricultural productivity increased without increasing the planted area, resulting in native forests protection and increase of the food availability. Some kinds of fertilizer have in their chemical composition some radionuclides due the origin of its feedstock, such as 238 U, the 232 Th, and their descendants, beyond 40 K. Knowledge of the radioactivity levels in the environment is great importance to know the gamma radiation dose that the human being is exposed. For identification and quantitation of radionuclides, it was used gamma spectrometry where HPGe detector was used to obtain the spectra, and LabSOCS software for calculating the detection efficiency for each energy. The values of 232 Th specific concentrations ranged from 4.1 to 368.1 Bq.Kg -1 , the values of 238 U specific concentrations ranged from 16.0 to 647.7 Bq.Kg -1 and 40 K specific concentrations ranged from 19.1 to 12713 Bq.Kg -1 . Concentrations of values are consistent with those found in literature. (author)

Development of a Lunar Scintillometer as part of the national large optical telescope site survey

Science.gov (United States)

Surendran, Avinash; Parihar, Padmakar S.; Banyal, Ravinder K.; Kalyaan, Anusha

2018-03-01

Ground layer turbulence is a very important site characterization parameter used to assess the quality of an astronomical site. The Lunar Scintillometer is a simple and effective site-testing device for measuring the ground layer turbulence. It consists of a linear array of photodiodes which are sensitive to the slight variations in the moon's brightness due to scintillation by the lower layers of the Earth's atmosphere. The covariance of intensity values between the non-redundant photodiode baselines can be used to measure the turbulence profile from the ground up to a height determined by the furthest pair of detectors. The six channel lunar scintillometer that has been developed at the Indian Institute of Astrophysics is based closely on an instrument built by the team led by Andrei Tokovinin of Cerro Tololo Inter-American Observatory (CTIO), Chile (Tokovinin et al., Mon. Not. R. Astron. Soc. 404(3), 1186-1196 2010). We have fabricated the instrument based on the existing electronic design, and have worked on the noise analysis, an EMI (Electromagnetic Induction) resistant PCB design and the software pipeline for analyzing the data from the same. The results from the instrument's multi-year campaign at Mount Saraswati, Hanle is also presented.

An Initial Meteoroid Stream Survey in the Southern Hemisphere Using the Southern Argentina Agile Meteor Radar (SAAMER)

Science.gov (United States)

Janches, D.; Hormaechea, J. L.; Brunini, C.; Hocking, W.; Fritts, D. C.

2013-01-01

We present in this manuscript a 4 year survey of meteor shower radiants utilizing the Southern Argentina Agile Meteor Radar (SAAMER). SAAMER, which operates at the southern most region of South America, is a new generation SKiYMET system designed with significant differences from typical meteor radars including high transmitted power and an 8-antenna transmitting array enabling large detected rates at low zenith angles. We applied the statistical methodology developed by Jones and Jones (Jones, J., Jones, W. [2006]. Month. Not. R. Astron. Soc. 367, 1050-1056) to the data collected each day and compiled the results into 1 composite representative year at 1 resolution in Solar Longitude. We then search for enhancements in the activity which last for at least 3 days and evolve temporally as is expected from a meteor shower. Using this methodology, we have identified in our data 32 shower radiants, two of which were not part of the IAU commission 22 meteor shower working list. Recently, SAAMER's capabilities were enhanced by adding two remote stations to receive meteor forward scatter signals from meteor trails and thus enable the determination of meteoroid orbital parameters. SAAMER started recording orbits in January 2012 and future surveys will focus on the search for unknown meteor streams, in particular in the southern ecliptic sky.

EVERYTHING MOVES NOTHING STANDS STILL. SOME ASPECTS ABOUT THE MEGASYSTEM EARTH ECO-SOC-ECO

Directory of Open Access Journals (Sweden)

Negucioiu Aurel

2012-12-01

Full Text Available One of the most important moments of the start or restart of the academic activity has always been the opening of courses in each subject (discipline that would be studied. On these occasions each professor shows to the students the subject of the discipline, place and role that intellectual seizure of that object in the formation of their professional competence required by the exigencies of the time. Most teachers stop on the most important sources, sources of knowledge that young learners can turn to and would be better to turn. They indicate written sources, books, magazines and other publications available in classical libraries and add, especially now, the world’s largest library: the Internet. However, teachers advise students to seek permanently another source, a "book" - permanently opened, the book of reality that contains the most truth and what is very important - many problems waiting to be discovered and resolved. Leafing over "the first pages" of one of the "volumes" of this huge established "book", I found that the paradigm "Everything moves. Nothing stands still" as the paradigm "movement is absolute, and the repose - roughly" is far from having exhausted full knowledge of "everything". But knowledge can enrich through investigation of the unknown aspects. Substantially reducing the size of the unknown we have subscribed to communicate, stopping on several sides and objectives of the issues: Further examination of the main contents of the concept of development; Nominate a limited number of forms of movement in the "kingdom" of the Megasystem Eco-soc-eco; Further investigation of the causes of motion; Pace to and rhythm in which the different forms of movement develop; Which are the directions in which evolve different directions of movement forms.

Illinois highway materials sustainability efforts of 2015.

Science.gov (United States)

2016-08-01

This report provides a summary of the sustainability efforts of the Illinois Department of Transportation (IDOT) in recycling : reclaimed materials in highway construction during calendar year 2015. This report meets the requirements of Illinois Publ...

Effect of fruiting on micronutrients, antinutrients and toxic substances ...

African Journals Online (AJOL)

use

fluted pumpkin (Telfaria occidentalis Hook F.) Seed oil and tropical ... ecological, nutritional and social approach to small scale house food production. Publ. Centre for ... Lanyasunya TP, Wang HR, Kariuki ST, Kuria, DM, Check AL, Mukisira.

Illinois highway materials sustainability efforts of 2016.

Science.gov (United States)

2017-07-04

This report provides a summary of the sustainability efforts of the Illinois Department of Transportation (IDOT) in recycling : reclaimed materials in highway construction during calendar year 2016. This report meets the requirements of Illinois Publ...

Effects of de-oiled palm kernel cake based fertilizers on sole maize ...

African Journals Online (AJOL)

AJL

2012-03-08

Mar 8, 2012 ... formulations on the yield of sole maize and cassava crops. Two de-oiled palm ..... establishment of nitrogen fixing bacteria in the rhizosphere. Microb ... Biological, and Social Sciences Research, 2nd Edition. Optimal Publ.

PMSC-D-15-00388.pdf | publ...oming | Indian Academy of Sciences

Indian Academy of Sciences (India)

error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. Ethical Guidelines and Procedures document. Posted on 17 January 2017. A revised version of the document 'Scientific Values: Ethical Guidelines ...

Compilation of nuclear decay data used for dose calculations. Data for radionuclides not listed in ICRP publication 38

Energy Technology Data Exchange (ETDEWEB)

Endo, Akira; Yamaguchi, Yasuhiro [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment; Tamura, Tsutomu

1999-07-01

Nuclear decay data used for dose calculations were compiled for 162 nuclides with half-lives greater than or equal to 10 min that are not listed in ICRP Publication 38 (Publ. 38) and their 28 daughter nuclides. Additional 14 nuclides that are considered to be important in fusion reactor facilities were also included. The data were compiled using decay data sets of the Evaluated Nuclear Structure Data File (ENSDF), the latest version in August 1997. Investigations of the data sets were performed to check their consistency by referring to recent literature and NUBASE, the database for nuclear and decay properties of nuclides, and by using the utility programs of ENSDF. Possible revisions of the data sets were made for their format and syntax errors, level schemes, normalization records, and so on. The revised data sets were processed by EDISTR in order to calculate the energies and intensities of {alpha} particles, {beta} particles, {gamma} rays including annihilation photons, internal conversion electrons, X rays, and Auger electrons emitted in nuclear transformations of the radionuclides. For spontaneously fissioning nuclides, the average energies and intensities of neutrons, fission fragments, prompt {gamma} rays, delayed {gamma} rays, and {beta} particles were also calculated. The compiled data were presented in two types of format; Publ. 38 and NUCDECAY formats. This report provides the decay data in the Publ. 38 format along with decay scheme drawings. The data will be widely used for internal and external dose calculations in radiation protection. (author)

Guide to integrated management systems for industrial maintenance contractors; Guia de sistemas de gestao integrada para contratadas de manutencao industrial

Energy Technology Data Exchange (ETDEWEB)

Ruella, Nildemar Correa [PETROBRAS, Rio de Janeiro, RJ (Brazil); Lima, Gilson Brito Alves [Universidade Federal Fluminense (UFF), Niteroi, RJ (Brazil)

2004-07-01

Presentation of an integrated management systems guide to hired of services of industrial maintenance with base in the management systems normative requisites and guides of the quality (ISO 9001, ISO 9004, ISO TS 29001 e API SPEC Q1), of environmental management systems (ISO 14001 and ISO 14004), of safety and occupational health management systems (BSI BS 8800, BSI OHSAS 18001, BSI OHSAS 18002 and ILO OSH 2001), of social accountability (SA 8000 and Implementation Guide of the SA 8000), publications and recommended practices (API RP 76, API RP 2220, API RP 2221, API Publ 9100 Publ A/B, API RP 760, API RP 761, AS/NZS 4581, CCS OAUPE009, ARPEL Guide N. 1, OGP Report No. 6.36/210, OGP Report No. 6.64/291, etc) and success experiences in the Brazil petroleum and gas industry. (author)

Influencia de la marea astronómica sobre las variaciones del nivel del Río Negro en la zona de Carmen de Patagones

Directory of Open Access Journals (Sweden)

Enrique D'Onofrio

2010-12-01

Full Text Available El Río Negro, límite natural entre las provincias de Buenos Aires y Río Negro, es uno de los ríos más importantes de la Patagonia que desemboca en el Océano Atlántico. Es navegable desde su desembocadura hasta Carmen de Patagones por embarcaciones de hasta 2,04 m de calado, dificultándose por irregularidades en la profundidad aguas arriba. La onda de marea proveniente del océano Atlántico ingresa al río haciendo que este adopte un régimen semidiurno hasta Carmen de Patagones. El conocimiento de la onda de marea en este tramo del río es de fundamental importancia para la calibración de modelos numéricos, el perfeccionamiento de los sistemas de alerta de inundaciones y la toma de decisiones relacionadas con el manejo costero. En este trabajo se analizan cuatro series de mediciones de marea, dos obtenidas en el hidrómetro de Carmen de Patagones con una duración de 608 y 731 días, una de 77 días proveniente de un mareómetro instalado en el kilómetro 18 del río y una de 79 días obtenida con un sensor de presión fondeado en proximidades de Punta Redonda (desembocadura del Río Negro. Se calculan y comparan los espectros de potencia de las alturas observadas en los tres sitios para detectar los cambios energéticos producidos en la banda de frecuencias correspondientes a la marea astronómica. De su comparación surge que la energía de las componentes semidiurnas y diurnas disminuye un 22% y un 45% respectivamente desde la desembocadura del Río Negro hasta Carmen de Patagones. En contraposición se observa un ligero aumento de la energía correspondiente a las frecuencias de las componentes cuarto diurnas. Esto se debe fundamentalmente a procesos no lineales inducidos por aguas someras y a irregularidades en la morfología del fondo del río. Para obtener las amplitudes y épocas de la marea se realizan análisis armónicos por el método de cuadrados mínimos. Las amplitudes de las componentes diurnas en Carmen de Patagones

Comments on ''The optimization of electronic precision in ultrasonic velocity measurements: A comparison of the time interval averaging and sing around methods'' [J. Acoust. Soc. Am. 73, 1833--1837 (1983)

International Nuclear Information System (INIS)

Karplus, H.B.

1984-01-01

J. D. Aindow and R. C. Chivers [J. Acoust. Soc. Am. 73, 1833 (1983)] compared the precision of the direct ''time-of-flight'' technique with the ''sing-around'' method for sound velocity measurement. Their conclusion is changed by the newer, faster, commercial clocks (2 ns HP5345<0.1 ns HP5370), giving the advantage to the time of flight method. The analysis is herewith augmented by calculating the time jitter in terms of signal to noise ratio, which was correctly shown to be negligible with 100-ns clocks, but becomes increasingly more significant with faster clocks

78 FR 45495 - Conejos Peak Ranger District, Rio Grande National Forest; Colorado; Cumbres Vegetation Management...

Science.gov (United States)

2013-07-29

..., Team Leader, San Luis Valley Publ ic Land Center, 1803 W. Hwy 160, Monte Vista, CO 81144. Commen ts may... the long-term. Responsible Official Conejos Peak District Ranger at 15571 County Road T5, La J ara, CO...

n gereformeerd-narratiewe pas- torale terapie 1. probleemstelling

African Journals Online (AJOL)

Worldview Lifestyle” te Yalta, Crimea. MORGAN A. 2000. What is narritive therapy? Adelaide: Dulwich Centre Publ. MÜLLER, J. 2004. A narrative-based pastoral conversation following the experience of trauma. Praktiese Teologie in SA 19(1):77-88 ...

CORS 911 : continuously operating reference stations for the Bayou Corne sinkhole.

Science.gov (United States)

2013-06-01

The sinkhole located near the Napoleonville Salt Dome in Assumption Parish, Louisiana : threatens the stability of LA 70 a state maintained route. In order to mitigate the : possible damaging eff ects of the sinkhole to the route and address publ...

Experiment list: SRX026636 [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available ody=ETO1 (A710) || antibody vendor=n/a (commercialization pending manuscript publ...ication) || antibody catalog number=n/a (commercialization pending manuscript publication) || antibody lot/b...atch number=n/a (commercialization pending manuscript publication) http://dbarchive.biosciencedbc.jp/kyushu-

40 CFR 35.718 - Award limitation.

Science.gov (United States)

2010-07-01

... included in the Performance Partnership Grant work plan. Hazardous Waste Management Program Grants (Pub.L... ASSISTANCE Environmental Program Grants for Tribes Toxic Substances Compliance Monitoring (section 28) § 35.718 Award limitation. If the Toxic Substances Compliance Monitoring grant funds are included in a...

Reconnaissance Marine Geophysical Survey for the Shallow Water Acoustics Program

Science.gov (United States)

2013-09-30

Swift, D.J.P. (Ed.), Shelf Sand and Sandstone Bodies: Geometry, Facies and Sequence Stratigraphy, Wiley, Hoboken, New Jersey, Spec. Publs. Int. Ass...sequences, their component system tra cts, and bounding surfaces. In Swift, D.J.P. (Ed.), Shelf Sand and Sandstone Bodies: Geometry, Facies and Sequence

Astronomía en la cultura

Science.gov (United States)

López, A.; Giménez Benitez, S.; Fernández, L.

La Astronomía en la Cultura es el estudio interdisciplinario a nivel global de la astronomía prehistórica, antigua y tradicional, en el marco de su contexto cultural. Esta disciplina abarca cualquier tipo de estudios o líneas de investigación en que se relacione a la astronomía con las ciencias humanas o sociales. En ella se incluyen tanto fuentes escritas, relatos orales como fuentes arqueológicas, abarcando entre otros, los siguientes temas: calendarios, observación práctica, cultos y mitos, representación simbólica de eventos, conceptos y objetos astronómicos, orientación astronómica de tumbas, templos, santuarios y centros urbanos, cosmología tradicional y la aplicación ceremonial de tradiciones astronómicas, la propia historia de la astronomía y la etnoastronomía (Krupp, 1989) (Iwaniszewski, 1994). En nuestro trabajo abordamos la historia y situación actual de esta disciplina, sus métodos y sus relaciones con otras áreas de investigación.

Propidium monoazide reverse transcription PCR and RT-qPCR for detecting infectious enterovirus and norovirus

Science.gov (United States)

Presently there is no established cell line or small animal model that allows for the detection of infectious human norovirus. Current methods based on RT-PCR and RT-qPCR detect both infectious and non-infectious virus and thus the conclusions that may be drawn regarding the publ...

Immunization Safety Review: Thimerosal - Containing Vaccines and Neurodevelopmental Disorders

National Research Council Canada - National Science Library

Stratton, Kathleen; Gable, Alicia; McCormick, Marie C

2001-01-01

..., and Marie C.McCormick, Editors Immunization Safety Review Committee Board on Health Promotion and Disease Prevention INSTITUTE OF MEDICINE NATIONAL ACADEMY PRESS Washington, D.C. Copyrightoriginal retained, the be not from cannot book, paper original however, for version formatting, authoritative the typesetting-specific created from the as publ...

Use of Laboratory Animals in Biomedical and Behavioral Research

National Research Council Canada - National Science Library

1988-01-01

... of Laboratory Animals in Biomedical and Behavioral Research Commission on Life Sciences National Research Council Institute of Medicine NATIONAL ACADEMY PRESS Washington, D.C. 1988 Copyrightoriginal retained, the be not from cannot book, paper original however, for version formatting, authoritative the typesetting-specific created from the as publ...

Het sluiten van een huurovereenkomst door middel van nieuwe telecommunicatiemiddelen

NARCIS (Netherlands)

Deli, D.E.J.A.

2001-01-01

In 2000 werden twee nieuwe wettelijke regelingen in België ingevoerd om uitwerking te geven aan de Europese Richtlijn 1999/93/EG van 13 december 1999 'betreffende een gemeenschappelijk kader voor elektronische handtekeningen' (Publ.L EG 19 januari 2000, afl. 13, 12-20). In dit artikel worden de

78 FR 14278 - Privacy Act of 1974; System of Records

Science.gov (United States)

2013-03-05

... Logistics; Pub.L. 95-521, Ethics in Government Act; and DoD Directive 7050.5, Coordination of Remedies for Fraud and Corruption Related to Procurement Activities.'' Purpose(s): Delete entry and replace with... or group of individuals or other entities from DLA procurement and sales.'' Routine uses of records...

Use of LabSOCS for determination of specific concentrations of {sup 40}K, {sup 238}U and {sup 232}Th in fertilizer samples; Uso de LabSOCS no calculo da eficiencia de detecao para determinacao da concentracao especifica de {sup 40}K, {sup 238}U e {sup 232}Th em amostras de fertilizantes

Energy Technology Data Exchange (ETDEWEB)

Garcez, Ricardo Washington Dutra; Lopes, Jose Marques; Silva, Ademir Xavier da, E-mail: rgarcez@con.ufrj.br, E-mail: marqueslopez@yahoo.com.br [Coordenacao dos Programas de Pos-Graduacao em Engenharia (COPPE/UFRJ), Rio de Janeiro, RJ (Brazil). Programa de Engenharia Nuclear; Domingues, Alessandro Mariano; Lima, Marco Frota, E-mail: slessandrodomingues@fisica.if.uff.br, E-mail: marcofrotalima@yahoo.com.br [Universidade Federal Fluminense (UFF), Niteroi, RJ (Brazil). Instituto de Biologia

2015-07-01

Use of fertilizer is an established practice worldwide to promote agricultural productivity increased without increasing the planted area, resulting in native forests protection and increase of the food availability. Some kinds of fertilizer have in their chemical composition some radionuclides due the origin of its feedstock, such as {sup 238}U, the {sup 232}Th, and their descendants, beyond {sup 40}K. Knowledge of the radioactivity levels in the environment is great importance to know the gamma radiation dose that the human being is exposed. For identification and quantitation of radionuclides, it was used gamma spectrometry where HPGe detector was used to obtain the spectra, and LabSOCS software for calculating the detection efficiency for each energy. The values of {sup 232}Th specific concentrations ranged from 4.1 to 368.1 Bq.Kg{sup -1} , the values of {sup 238}U specific concentrations ranged from 16.0 to 647.7 Bq.Kg{sup -1} and {sup 40}K specific concentrations ranged from 19.1 to 12713 Bq.Kg{sup -1} . Concentrations of values are consistent with those found in literature. (author)

Pre-astronomica navigation in antiquity: the use of birds for nautical orientation | La navegación pre-astronómica en la antigüedad: utilización de pájaros en la orientación náutica

Directory of Open Access Journals (Sweden)

José María Luzón Nogué

1986-12-01

Full Text Available This paper deals with the use of birds (ravens and doves as attendants of the sailors to search the coast from the sea. This use is documented since the III millennium B. C. in the Aegean Sea. The possibilities and limitations of this art of sailing are very important to the cultural interrelationship in the Mediterranean. An experience performed in 1986 has allowed us to verify the efficiency of the birds to guide sailors in high sea. The astronomical orientation assumes the possibility of big return routes, which are radically changing the cultural and economic panorama of the Mediterranean since the I millennium B. C. | El presente estudio reúne los datos referentes a la utilización de pájaros (preferentemente cuervos y palomas como auxiliares de los navegantes, para buscar la costa desde alta mar. Su utilización está documentada desde el tercer milenio a. C. en Oriente y durante el segundo milenio a. C. en el Egeo. De las posibilidades y limitaciones de esta forma de navegar depende en gran medida la interrelación cultural en el Mediterráneo. Un experimento practicado realizado en 1986 permite comprobar la eficacia de la suelta de aves para orientar a los navegantes que se pierden en alta mar. La orientación astronómica supone la posibilidad de grandes rutas de ida y vuelta que van a cambiar radicalmente el panorama cultural y económico del Mediterráneo a partir del primer milenio a. C.

Dynamical passage to approximate equilibrium shapes for spinning, gravitating rubble asteroids

Science.gov (United States)

Sharma, Ishan; Jenkins, James T.; Burns, Joseph A.

2009-03-01

Many asteroids are thought to be particle aggregates held together principally by self-gravity. Here we study — for static and dynamical situations — the equilibrium shapes of spinning asteroids that are permitted for rubble piles. As in the case of spinning fluid masses, not all shapes are compatible with a granular rheology. We take the asteroid to always be an ellipsoid with an interior modeled as a rigid-plastic, cohesion-less material with a Drucker-Prager yield criterion. Using an approximate volume-averaged procedure, based on the classical method of moments, we investigate the dynamical process by which such objects may achieve equilibrium. We first collapse our dynamical approach to its statical limit to derive regions in spin-shape parameter space that allow equilibrium solutions to exist. At present, only a graphical illustration of these solutions for a prolate ellipsoid following the Drucker-Prager failure law is available [Sharma, I., Jenkins, J.T., Burns, J.A., 2005a. Bull. Am. Astron. Soc. 37, 643; Sharma, I., Jenkins, J.T., Burns, J.A., 2005b. Equilibrium shapes of ellipsoidal soil asteroids. In: García-Rojo, R., Hermann, H.J., McNamara, S. (Eds.), Proceedings of the 5th International Conference on Micromechanics of Granular Media, vol. 1. A.A. Balkema, UK; Holsapple, K.A., 2007. Icarus 187, 500-509]. Here, we obtain the equilibrium landscapes for general triaxial ellipsoids, as well as provide the requisite governing formulae. In addition, we demonstrate that it may be possible to better interpret the results of Richardson et al. [Richardson, D.C., Elankumaran, P., Sanderson, R.E., 2005. Icarus 173, 349-361] within the context of a Drucker-Prager material. The graphical result for prolate ellipsoids in the static limit is the same as those of Holsapple [Holsapple, K.A., 2007. Icarus 187, 500-509] because, when worked out, his final equations will match ours. This is because, though the formalisms to reach these expressions differ, in statics

Soil Carbon Sequestration and the Greenhouse Effect (2nd Edition)

Science.gov (United States)

This volume is a second edition of the book “Soil Carbon Sequestration and The Greenhouse Effect”. The first edition was published in 2001 as SSSA Special Publ. #57. The present edition is an update of the concepts, processes, properties, practices and the supporting data. All chapters are new co...

A Review of the Systematics and a Proposed Scheme of Internal Classification of the New World Subgenus Melanoconion of Culex (Diptera, Culicidae)

Science.gov (United States)

1982-01-01

Floch, H. and E. Abonnenc 1947. Distribution des moustiques du genre Cutex en &yane Francaise. Publ. Inst. Pasteur Guyane Ter. Inini, No. 146:1-g...Senevet, G. and E. Abonnenc 1939. Los moustiques de la &yane Francaise -- II. le genre CuZex. Arch. Inst. Pasteur Alger. 17:62-134. Sirivanakarn

40 CFR 35.723 - Competitive process.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Competitive process. 35.723 Section 35... Grants (pub.l. 105-276) § 35.723 Competitive process. EPA will award Tribal hazardous waste program... guidance. After the competitive process is complete, the recipient can, at its discretion, accept the award...

Naval Health Research Center (NHRC) Report for the Calendar Year 1981.

Science.gov (United States)

1981-01-01

naval careers. Following many months of preparation, with reviews by MSC Specialty Advisors and the USC Division (BUMED), a mail questionnaire was sent...PublZic:tion, DTIC AD# A104-813) of Clinical . robo ~oji, (in press) Abstract: The diagnosis of group A streptococcal disease still relies on isolation on

(Thunb.), (Orthoptera: Pyrgomorphidae)

African Journals Online (AJOL)

A study of the genus Chrotogonus IV. Wing polymorphism, technical designations and synonymy. Tijdschr. Ent. 100: 43-60. KEVAN, O.K. 1959. A study of the genus Chrotogonus VI. History and biogeography of Chrotogonini. Publ. Cielt. Compo. Diam. Angola No. 43: 201 - 246. VAN OER MERWE, C.P. & KENT, C.C. 1925.

The histology of dermal glands of mating Breviceps with comments ...

African Journals Online (AJOL)

CONAWAY, C.H. & METTER, D.E. 1967. Skin glands associated with breeding in Microhyla carolinensis. Copeia 3: 672 - 673. FITCH, H.S. 1956. A field study of the Kansas ant-eating frog,. Gaslrophryne olivacea. Univ. Kans. Publ. Mus. Nal. Hisl. 8;. 275 - 306. INGER, R.F. 1954. Systematics and zoogeography of Philippine.

Short notes and reviews Insect history

NARCIS (Netherlands)

Schram, Frederick R.

2003-01-01

Review of: History of Insects, edited by A. P. Rasnitsyn and D. L. J. Quicke. Kluwer Academic Publ., Dordrecht, Netherlands, 2002, 517 pp., ISBN 14 0200 026 X In the winter of 1977, I visited the Paleontological Institute of the Academy of Sciences in Moscow. I wanted to study the type specimens of

ONR Europe Reports. Computer Science/Computer Engineering in Central Europe: A Report on Czechoslovakia, Hungary, and Poland

Science.gov (United States)

1992-08-01

Routing on Printed Circuit Boards. Computer Aided Design, Vol.12, No.5, 1980, pp.231-234. 15 Servit, M.: Heuristic Algorithms for Rectilinear Steiner ...practical utilization ver. 5.0, KOPP publ. comp., 1992 Herout P, Rudolf V., Smrha P.: ABC of Programmer in the C Language (ANSI C, Borland C and C++), KOPP

Magnetic Properties of Three Impact Structures in Canada

Science.gov (United States)

Scott, R. G.; Pilkington, M.; Tanczyk, E. I.; Grieve, R. A. F.

1995-09-01

. The Clearwater Lakes impact structures are two complex craters formed in Archean retrograde granulite facies rocks [4]. Clearwater West, at 36 km diameter, has an annular ring of islands and a shallowly submerged central uplift. Clearwater East, at 26 km diameter, has a more deeply submerged central uplift. The structures are characterised by highly oxidized melt rock and melt- breccia lenses exposed at the surface. Shocked crystalline basement rocks and minor amounts of breccia and melt rock occur in the central uplifts [5]. Despite relatively little alteration at depth, these rocks exhibit both susceptibilities and remanent magnetizations well below the regionally high values. The Clearwater rocks also contain a thermoremanent reversed magnetization, acquired at the time of impact, and characteristic of the Permo-Carboniferous Reversed Polarity Superchron. The magnetization is carried by titanomagnetite in Clearwater West, and both magnetite and pyrrhotite in Clearwater East. This reversed magnetization contributes to the magnetic low, but cannot account for all of it. The intense airborne magnetic low (> 500 nT) requires a significant contribution from the shocked basement at depth, produced by either alteration of magnetic phases along fractures, or reduction in magnetic properties by lower shock levels away from the point of impact [6]. References: [1] Pilkington M. and Grieve R. A. F. (1992) Rev. Geophys., 30, 161-181. [2] Innes M. J. S. et al. (1964) Publ. Dom. Obs. Ottawa, 31, 19-52. [3] Halliday I. and Griffin A. A. (1967) J. Roy. Astron. Soc. Can., 61, 1-8. [4] Simonds C. H. et al. (1978) LPS IX, 2633-2658. [5] Hische R. (1994) Unpublished Ph.D. thesis, Munster. [6] Pohl J. (1994) 3rd Intl. Wkshp., ESF Network Impact Cratering and Evol. of Planet Earth, Shockwave Behavior in Nature and Expt., Progr. Abstr., 51.

Brazil - Governance in Brazil's Unified Health System : Raising the Quality of Public Spending and Resource Management

OpenAIRE

World Bank

2007-01-01

This report on governance in Brazil's unified health system assesses resource allocation and management, planning and budgeting functions, and budget execution at different levels of government for public expenditures on health services. The emphasis is on understanding the incentives generated for service providers, and the overall soundness of the accountabilities established in the publ...

Marine Environmental Planning Guide for the Hampton Roads/Norfolk Operating Area.

Science.gov (United States)

1974-05-01

algae of the American coast between Cape May, New Jersey, and Cape Hatteras, North Carolina, I. The Cyanophyta. Botanica Marina, 9, pp. 101-128, 1966...oBell, C. E. Marine microbiology, Chronica Botanica Co. Publ., Waltham, Mass., 240p., 194T. I 169 APPENDIX A. PHYSICAL DATA 169 76** 75 " 74 " 73 1264

Effects of Stencil Width on Surface Ocean Geostrophic Velocity and Vorticity Estimation from Gridded Satellite Altimeter Data

Science.gov (United States)

2012-03-17

Texas at Austin, Austin, Texas, USA. g dq ’Departement de Physique and LPO, Universite de Bretagne V _ /" r5r’ Occidental, Brest ...Italy, ESA Publ, WPP-366, Eur. Space Agency, Paris . Shriver, J. F.,’ H. E. Hurlburt, O. M. Smcdstad, A. J. Wallcraft, and R. C. Rhodes (2007), 1/32

Taxonomy and Biology of Phlebotomine Vectors of Human Disease

Science.gov (United States)

1987-12-31

Sobre o encontro de Lutzomyiu longipalpis (Lutz & Neiva, 1912) no Estado de Sao Paulo, Brasil, Rev. Saude Publ. Sac Paulo 4:99-100. 3 Forattini, 0. P...Almeida. /1964. Flebotomos do nordeste. I. Encontro de "Plboou cht, " "P. gmgxi e ’T. 1QnstispinJ. em Pernambuco (Diptera, Psychodidae). Rev. Brasil. Biol

DIGGING HISTORY: AN INTERACTION OF ARCHAEOLOGY WITH ...

African Journals Online (AJOL)

involving excavations, analysis and publ1cat1on of results. They also ... with a five-lecture course and field trip which was enthusiastically ... been to treat it as a finite subject with definite right and wrong ... ties, not to mention other elements like the Berge- naars, or the ... Pottery was first introduced to the Northern Cape by.

The Battle of Savo Island August 9th, 1942. Strategical and Tactical Analysis. Part I

Science.gov (United States)

1950-01-01

Department publIcation SSC-677, Survey of the Bolcmon Islands. March 16, 1943, Confidential. *OCTW 62 personal latter to Captain RC. Parker, USN(Ret...cakiral Jellicu had si&Unalled Ad- miral Oqattr "Wh•re !e the anek-q’s battles Fleet?" and Lsirl Beatty •had repliid la a most v& omnic kid inoomplete m

Die belangrikste kenmerk van die diereproduksie- bedrywe oor die ...

African Journals Online (AJOL)

digdhede teen 1980 uit 'n kudde van 30 rnilj.skape ge- produseer moet word. Tweedens sal die faktore ... die Republiek van Suid-Mrika teen 1980 in totaal 28 milj. sal wees. Indien die produsente dit as 'n ..... Appendix Table 4 in Digestive Physiology and nutrition of ruminants Vol. 3 Ed. and Publ. D.C. Church, Oregon State ...

Percepção astronómica de um grupo de alunos do ensino médio de uma escola da rede estadual de São Paulo

Science.gov (United States)

de Oliveria, E. F.; Voelzke, M. R.

2009-03-01

Sendo a Astronomia uma das cièncias mais antigas da humanidade, e considerando sua importáncia histórica e cultural, é de extrema releváncia que tópicos relacionados a ela sejam tratados nas escolas. Embora os Parámetros Curriculares Nacionais do Ensino Médio (PCN-EM) e as Orientaçiacute;es Complementares aos Parámetros (PCN+) apontem a importáncia de uma abordagem significativa de conceitos relacionados à Astronomia nas aulas de Física, muitos estudantes terminam o Ensino Médio (EM) sem compreender a razão de certos acontecimentos de origem celeste, ainda que estes façam parte de seu cotidiano e sejam alvos da curiosidade natural dos jovens. Da observação dessa curiosidade em alunos de uma escola pública paulista, na cidade de Suzano, surgiu o interesse em investigar os conhecimentos básicos em Astronomia dos alunos do Ensino Médio desta escola, constituindo-se este como principal objetivo desta pesquisa. Para tanto foi elaborado um questionário de múltipla escolha aplicado inicialmente a 34 alunos do primeiro ano e, posteriormente, a mais 310, distribuídos entre as très séries do Ensino Médio dos períodos matutino e noturno. Dessa forma, observou-se que 73,9% dos estudantes identificaram o Sol como sendo uma estrela, 67,1% mostraram compreender a sucessão entre dia e noite e 52,3% relacionaram o Big Bang à origem do Universo. Em contrapartida, apenas 34,5% relacionaram as estaçíes do ano à inclinação do eixo de rotação da Terra, 21,3% indicaram a influència gravitacional simultánea da Lua e do Sol como responsável pelo fenòmeno das marés, 24,5% indicaram corretamente quais são os objetos celestes mais próximos da Terra, 36,1% identificaram ano-luz como uma medida de distáncia e 34,2% reconheceram as estrelas cadentes como meteoros, evidenciando-se assim o pequeno discernimento dos estudantes quanto aos fenòmenos e termos astronòmicos do cotidiano. Além disso, foram comparadas as respostas de alun! os de diferentes s

Using intra annual density fluctuations and d13C to assess the impact of summer drought on Mediterranean ecosystem

Science.gov (United States)

Battipaglia, G.; Brand, W. A.; Linke, P.; Schaefer, I.; Noetzli, M.; Cherubini, P.

2009-04-01

. 78: 119-14 Fritts, H.C. 1976. Tree rings and climate. Academic Press, London, UK. Hughes, M.K. 2002. Dendrochronology in climatology - the state of the art. Dendrochronologia 20: 95-116. Schulman, E. 1938. Classification of false annual rings in Monterey pine. Tree-Ring Bull. 4:4-7 Schweingruber FH (1988) Tree-ring: Basics and applications of dendrochronology. Reidel. Publ., Dordrecht, 276 p Tingley, M.A. 1937. Double growth rings in Red Astrachan. Proc. Am. Soc. Hort. Sci. 34: 61.

Communicating health risks to the public: a global perspective

National Research Council Canada - National Science Library

Hillier, Dawn

2006-01-01

... under the Copyright, Designs and Patents Act, 1988, to be identified as the author of this work. British Library Cataloguing in Publication Data Communicating health risks to the public : a global perspective 1. Health risk communication I. Hillier, Dawn, 1950- 614.4'4 ISBN-13: 978-0-566-08672-4 ISBN-10: 0 566 08672 7 Library of Congress Cataloging-in-Publ...

Untitled

Indian Academy of Sciences (India)

Hamburg 15. (1945) 211–261 -. Deligne P and Mumford D, The irreducibility of the space of moduli of a given genus, Publ. Math. IHES 36 (1969) 75–110. Deligne P and Rapoport M, Les schémas de modules de courbes elliptiques, Modular functions of one variables II, Springer Lecture Notes in Math. 349 (1973) 143–316.

Comprehensive and Critical Literature Review on Insitu Micro-Sensors for Application in Tribology

Science.gov (United States)

1994-04-01

Tsugai, Masahiro; Bessho, Mikio ; Araki, Toru; Onishi, Masayoshi; Sesekura, Takashi Source: SAE Technical Paper Series. Publ by SAE, Warrendale, PA, USA...MONITORING OF HYDROGEN ASSISTED CRACKING OF LOW ALLOY STEEL. Author. Hayashi, Yasuhisa; Takemoto, Mikio Source: Boshoku Gijutsu/Corrosion Engineering v...METALS AND ITS APPLICATION TO AE SENSOR. Author. Shimizu, Hiroshi; Watanabe, Hiroshi; Sato , Michio Source:. Japanese Journal of Applied Physics, Supplement

Real-Time Control System for Improved Precision and Throughput in an Ultrafast Carbon Fiber Placement Robot Using a SoC FPGA Extended Processing Platform

Directory of Open Access Journals (Sweden)

Gilberto Ochoa-Ruiz

2017-01-01

Full Text Available We present an architecture for accelerating the processing and execution of control commands in an ultrafast fiber placement robot. The system consists of a robotic arm designed by Coriolis Composites whose purpose is to move along a surface, on which composite fibers are deposed, via an independently controlled head. In first system implementation, the control commands were sent via Profibus by a PLC, limiting the reaction time and thus the precision of the fiber placement and the maximum throughput. Therefore, a custom real-time solution was imperative in order to ameliorate the performance and to meet the stringent requirements of the target industry (avionics, aeronautical systems. The solution presented in this paper is based on the use of a SoC FPGA processing platform running a real-time operating system (FreeRTOS, which has enabled an improved comamnd retrieval mechanism. The system’s placement precision was improved by a factor of 20 (from 1 mm to 0.05 mm, while the maximum achievable throughput was 1 m/s, compared to the average 30 cm/s provided by the original solution, enabling fabricating more complex and larger pieces in a significant fraction of the time.

Current status on preparation of dose conversion factors based on 1990 ICRP recommendations

International Nuclear Information System (INIS)

Yoshizawa, Michio

1996-01-01

The current status of arrangement of dose conversion factors for operational quantities are explained on the basis of 1995 ICRP-ICRU recommendations. The dose conversion factors of photon, neutron and electron were recommended by ICRP Publ. 74. It's contents are described. The relation between new dose conversion factors and the laws in connection with protecting radiation are explained. The dose conversion factors of 1 cm-, 3 mm- and 70 μm - dose equivalent which were introduced into the laws connected therewith in Japan are accepted the same values of ICRP Publ. 51 for photon and neutron. I mentioned the points of discussing about new dose conversion factors which are expected to be recommended. The laws have to show the dose conversion factors to be used by calculation and estimation of radiation shield, etc. The limit of energy of ICRU individual dose equivalent for photon is now until 1 MeV, but the value is insufficient and necessary to 10 MeV as same as the ambient dose equivalent in due consideration of atomic energy facilities. JAERI is preparing these dose conversion factors now. (S.Y.)

La geodesia y la investigación científica en la Francia del Siglo XIX la medición del arco de meridiano franco-argelino (1870-1895

Directory of Open Access Journals (Sweden)

Martina Schiavon

2004-07-01

Full Text Available En el siglo XIX la geodesia era fundamental para la astronómia y las ciencias de la tierra (cartografía, geología, geofísica y también para las disciplinas militares. En las opéraciones de medida de un arco de meridiano, de paralelo o de la posición astronómica de una estación geodésica, los oficiales militares han utilizado en el terreno las "técnicas" materiales y conceptuales que fueron creadas para observar las estrellas. En consecuencia, ellos han adaptado y modificado los conocimientos característicos del observatorio para medir los objetos terrestres. Sin embargo, los historiadores han raramente investigado la geodesia como una actividad del observatorio astronómico. En este articulo, considerando la geodesia como una actividad humana y una disciplina en la cual el astronomo y el oficial militar colaboraron, me propongo explorar los trabajos de terreno en geodesia y mostrar que las medidas de precisión de terreno constituyen una esfera sociológica, material y cognitiva por excelencia. Tomaré como ejemplo la medida de un arco de meridiano realizada bajo la dirección del capitán Francois Perrier, en Francia y Argelia entre 18701' 1895. PAIABRAS erAVES. Geodesia, medida y cultura de la precisión, ejército, XIX siglo, Francia

The relationship between extrinsic motivation, job satisfaction and life satisfaction amongst employees in a public organisation

OpenAIRE

Mafini, Chengedzai; Dlodlo, Nobukhosi

2014-01-01

Orientation: There is much research on extrinsic motivation, job satisfaction and life satisfaction in organisations. However, empirical evidence on how such factors affect employees in public organisations in developing countries is lacking. Research purpose: To examine the relationships between extrinsic motivation, job satisfaction and life satisfaction amongst employees in a public organisation. Motivation for the study: Labour strife is an endemic phenomenon in South Africa’s publ...

Caseload Management in the Law Courts: Methodology, Experiences and Results of the first Swiss Study of Administrative and Social Insurance Courts

OpenAIRE

Andreas Lienhard

2010-01-01

The judiciary in Switzerland – like all state bodies – is under increasing pressure to reform: On the one hand, workloads, the complexities dealt with and procedural requirements are all tending to grow in volume, while at the same time there are scarely any additional resources available to cope with the problem.By prof. dr. iur. Andreas Lienhard and mag. rer. publ. Daniel Kettiger

Caseload Management in the Law Courts: Methodology, Experiences and Results of the first Swiss Study of Administrative and Social Insurance Courts

Directory of Open Access Journals (Sweden)

Andreas Lienhard

2010-11-01

Full Text Available The judiciary in Switzerland – like all state bodies – is under increasing pressure to reform: On the one hand, workloads, the complexities dealt with and procedural requirements are all tending to grow in volume, while at the same time there are scarely any additional resources available to cope with the problem.By prof. dr. iur. Andreas Lienhard and mag. rer. publ. Daniel Kettiger

Polarimetric purity and the concept of degree of polarization

Science.gov (United States)

Gil, José J.; Norrman, Andreas; Friberg, Ari T.; Setälä, Tero

2018-02-01

The concept of degree of polarization for electromagnetic waves, in its general three-dimensional version, is revisited in the light of the implications of the recent findings on the structure of polarimetric purity and of the existence of nonregular states of polarization [J. J. Gil et al., Phys Rev. A 95, 053856 (2017), 10.1103/PhysRevA.95.053856]. From the analysis of the characteristic decomposition of a polarization matrix R into an incoherent convex combination of (1) a pure state Rp, (2) a middle state Rm given by an equiprobable mixture of two eigenstates of R, and (3) a fully unpolarized state Ru -3 D, it is found that, in general, Rm exhibits nonzero circular and linear degrees of polarization. Therefore, the degrees of linear and circular polarization of R cannot always be assigned to the single totally polarized component Rp. It is shown that the parameter P3 D proposed formerly by Samson [J. C. Samson, Geophys. J. R. Astron. Soc. 34, 403 (1973), 10.1111/j.1365-246X.1973.tb02404.x] takes into account, in a proper and objective form, all the contributions to polarimetric purity, namely, the contributions to the linear and circular degrees of polarization of R as well as to the stability of the plane containing its polarization ellipse. Consequently, P3 D constitutes a natural representative of the degree of polarimetric purity. Some implications for the common convention for the concept of two-dimensional degree of polarization are also analyzed and discussed.

Inclined asymmetric librations in exterior resonances

Science.gov (United States)

Voyatzis, G.; Tsiganis, K.; Antoniadou, K. I.

2018-04-01

Librational motion in Celestial Mechanics is generally associated with the existence of stable resonant configurations and signified by the existence of stable periodic solutions and oscillation of critical (resonant) angles. When such an oscillation takes place around a value different than 0 or π , the libration is called asymmetric. In the context of the planar circular restricted three-body problem, asymmetric librations have been identified for the exterior mean motion resonances (MMRs) 1:2, 1:3, etc., as well as for co-orbital motion (1:1). In exterior MMRs the massless body is the outer one. In this paper, we study asymmetric librations in the three-dimensional space. We employ the computational approach of Markellos (Mon Not R Astron Soc 184:273-281, https://doi.org/10.1093/mnras/184.2.273, 1978) and compute families of asymmetric periodic orbits and their stability. Stable asymmetric periodic orbits are surrounded in phase space by domains of initial conditions which correspond to stable evolution and librating resonant angles. Our computations were focused on the spatial circular restricted three-body model of the Sun-Neptune-TNO system (TNO = trans-Neptunian object). We compare our results with numerical integrations of observed TNOs, which reveal that some of them perform 1:2 resonant, inclined asymmetric librations. For the stable 1:2 TNO librators, we find that their libration seems to be related to the vertically stable planar asymmetric orbits of our model, rather than the three-dimensional ones found in the present study.

Measurement of Reactions on 30P for Nova Nucleosynthesis

Science.gov (United States)

Ma, Z.; Guidry, M. W.; Hix, W. R.; Smith, M. S.

2003-05-01

-sur-Yvette: Editions Frontiere), 525(SMOKER). 3. Iliadis, C. et al., Astrophys. J. Suppl., 134,151(2001). 4. Snijders et al., 1987 Snijders, M. A. J., et al., Mon. Not. Roy. Astron. Soc., 228, 329(1987). 5. Andrea, J., Drechsel, H., Starrfield, S., Astron. Astrophys., 291,869(1994) *Managed by UT-Battelle, LLC, for the U.S. Department of Energy under contract DE-AC05-00OR22725.

Reading and the reference librarian the importance to library service of staff reading habits

CERN Document Server

Dilevko, Juris

2003-01-01

""Informative""--Midwest Book Review; ""interesting and important...a page turner""--Catholic Library World; ""detailed...required reading...valuable...extensive body of very detailed information...outstanding""--LISR: Science Direct; ""thought-provoking...informative...solid, sensitive research...an important new primary resource""--Colorado Libraries; ""most remarkable and thought provoking...well done...articulate and insightful...fascinating...interesting...important and worthwhile""--Library & Information Science Research. The authors surveyed both academic reference librarians and publ

Total Quality Management (TQM) Bibliography

Science.gov (United States)

1990-04-01

Control de la Calidad ), Madrid, Spain pC8.3.1-C8.3.6; 1983. *QUALITY CONTROL--*JAPAN/LOW IN PRICE/LOW IN QUALITY/NATIONAL SCALE PROMOTION OF QUALITY...1986. THEORY/DOD-NAVY/AEROSPACE INDUSTRY/*QUALITY CONTROL--*MILITARY APPLICATIONS/PRODUCTIVITY/SYSTEMS ENGINEERING/NAVAL AIR REWORK FACILITIES...Program - National Electronic Packaging and Production Conference, 1984, Publ by Cahners Exposition Group, Des Plaines, Il, p436-438; 1984. PRODUCTION

249-IJBCS-Article-Dr Adomou Aristide

African Journals Online (AJOL)

Dr Gatsing

MPE and Traoré D (eds). CAB. International: UK and Cambridge; 19-39. INSAE 2002. Troisième recensement général de la population et de l'habitat. Résultats définitifs: Tableaux statistiques Cotonou,. Bénin, 4p. Lebrun J, Gilbert G. 1954. Une classification écologique des forêts du Congo. Publ. I.N.E.A.C., sér. Sc., 63: 89.

Privatization in the U.S. Navy

OpenAIRE

Perritt, Stuart E.

1990-01-01

CIVINS (Civilian Institutions) Thesis document Approved for public release ; distribution is unlimited Privatization does save money for the vast majority of functions. The clearest evidence to support this is a Pentagon study of 235 separate privatization competitions between 1980 and 1982. Follow-up studies indicated that competitive contracting saved 22%. A side benefit was that the in-house organizations that won their competitions improved on their precompetition costs by 18%. Publ...

Final Base Realignment and Closure (BRAC) Environmental Assessment for Realignment of Nellis Air Force Base

Science.gov (United States)

2007-03-01

weapons systems in support of potential technological improvements in hardware, software , tactics, and training. In recent years, the total amount of...communities in southeastern California, southern Nevada, western and southern Arizona, southwestern Utah, and through Sonora and northern Sinaloa, Mexico ...Publ ic Utilities Commi ssion Pete Konesky , Stat e Energy Of f i ce Rebecca Pa l me r , State Historic Preservation Office Alisa Huckle, ONR Libr a

Sediment Transport on Continental Shelves: Storm Bed Formation and Preservation in Heterogeneous Sediments

Science.gov (United States)

2012-01-01

occurred during the Cretaceous period. The simulated storm bed for such an extratropical cyclone that lasts 4 days was deposited as deep as 75 m and had...Int. Assoc. Sedimentol. Spec. Publ. (2012) 44, 295-310 Sediment transport on continental shelves: storm bed formation and preservation in...xDept. of Earth Science, Memorial University of Newfoundland, St. Johns, Newfoundland, Canada ABSTRACT Many storm beds are constructed of silt/sand

Army Hearing Program Status Report Quarter 2 Fiscal Year 2017

Science.gov (United States)

2017-07-01

U.S. Army Publ ic Heal th Center Army Hearing Program Status Report Q2 FY17 Clinical Public Health and Epidemiology Directorate Army... Hearing Division General Medical: 500A July 2017 Approved for public release; distribution unlimited Army Hearing Program Status Report, Q2FY17...56               INTRODUCTION The Army Hearing Program Status Report (AHPSR) is a component of the Public Health

Public and Private Physical Affection Differences between Same-Sex and Different-Sex Couples: The Role of Perceived Marginalization

OpenAIRE

Amani El-Alayli; Erin Kent

2011-01-01

Despite its connection with relationship satisfaction, research on physical affection is scarce and fails to disentangle private and public displays of affection. It is important to examine both types if marginalized couples are less comfortable displaying affection publicly. The present study examined whether same-sex couples display less public (but not private) physical affection than different-sex couples due to stronger feelings of relationship marginalization. It also examined how publ...

Segundo Catálogo Estelar del Hemisferio Sur con Astrolabio Fotoeléctrico PAII

Science.gov (United States)

Manrique, W. T.; Podestá, R. C.; Alonso, E.; Actis, E. V.; Pacheco, A. M.; Bustos, G.; Lizhi, L.; Zezhi, W.; Fanmiao, Z.; Hongqi, W.; Perdomo, R.

Recordamos que entre el Observatorio Astronómico ``Félix Aguilar'', el Observatorio Astronómico de Beijing y el Observatorio Astronómico de La Plata, se ha convenido en desarrollar un Proyecto de Investigación conjunto, para la observación sistemática de estrellas en el Hemisferio Sur, con el objeto de la elaboración de un Catálogo Estelar Global utilizando un Astrolabio Fotoeléctrico PAII del Observatorio de Beijing, que ha sido usado con éxito en la República de China. En este trabajo se presenta el Segundo Catálogo Estelar del Hemisferio Sur, derivado de las observaciones realizadas con el PAII instalado en el OAFA, durante el períiodo Febrero de 1992 a Marzo de 1997. En este lapso se han observado mas de 400000 pasajes estelares, obteniéndose las correcciones Δ α y Δ δ de 5241 estrellas del FK4, FK5, FK5 Ext., SRS, CAMC y GC. Las precisiones medias son del orden de ± 3,2 ms en ascensión recta y ±0."057 en declinación. Rango de magnitudes : 2,0 a 11,5 Rango de declinaciones : -3o a -60o Epoca Media : 1994.9 Se analizan los residuos en función de la magnitud y tipo espectral, correcciones de grupo y frecuencia de distribución Δ α y Δ δ.

Predicting bi-decadal organic carbon mineralization in northwestern European soils with Rock-Eval pyrolysis

Science.gov (United States)

Soucemarianadin, Laure; Barré, Pierre; Baudin, François; Chenu, Claire; Houot, Sabine; Kätterer, Thomas; Macdonald, Andy; van Oort, Folkert; Plante, Alain F.; Cécillon, Lauric

2017-04-01

The organic carbon reservoir of soils is a key component of climate change, calling for an accurate knowledge of the residence time of soil organic carbon (SOC). Existing proxies of the size of SOC labile pool such as SOC fractionation or respiration tests are time consuming and unable to consistently predict SOC mineralization over years to decades. Similarly, models of SOC dynamics often yield unrealistic values of the size of SOC kinetic pools. Thermal analysis of bulk soil samples has recently been shown to provide useful and cost-effective information regarding the long-term in-situ decomposition of SOC. Barré et al. (2016) analyzed soil samples from long-term bare fallow sites in northwestern Europe using Rock-Eval 6 pyrolysis (RE6), and demonstrated that persistent SOC is thermally more stable and has less hydrogen-rich compounds (low RE6 HI parameter) than labile SOC. The objective of this study was to predict SOC loss over a 20-year period (i.e. the size of the SOC pool with a residence time lower than 20 years) using RE6 indicators. Thirty-six archive soil samples coming from 4 long-term bare fallow chronosequences (Grignon, France; Rothamsted, Great Britain; Ultuna, Sweden; Versailles, France) were used in this study. For each sample, the value of bi-decadal SOC mineralization was obtained from the observed SOC dynamics of its long-term bare fallow plot (approximated by a spline function). Those values ranged from 0.8 to 14.3 gC·kg-1 (concentration data), representing 8.6 to 50.6% of total SOC (proportion data). All samples were analyzed using RE6 and simple linear regression models were used to predict bi-decadal SOC loss (concentration and proportion data) from 4 RE6 parameters: HI, OI, PC/SOC and T50 CO2 oxidation. HI (the amount of hydrogen-rich effluents formed during the pyrolysis phase of RE6; mgCH.g-1SOC) and OI (the CO2 yield during the pyrolysis phase of RE6; mgCO2.g-1SOC) parameters describe SOC bulk chemistry. PC/SOC (the amount of organic

Studies of Clump Structure of Photodissociation Regions at ...

Indian Academy of Sciences (India)

R. Narasimhan (Krishtel eMaging) 1461 1996 Oct 15 13:05:22

1992); Meixner & Tielens (1993); Robert & Pagani (1993); Bennet et al. (1994); ..... Castets, A., Duvert, G., Durtey, A., Bally, J., Langer, W. D., Wilson, R. W. 1990, Astron. ... Spitzer Jr., 1978, Physical Processes in the Interstellar Matter (John Wiley).

Effect of nutrient enrichment on the source and composition of sediment organic carbon in tropical seagrass beds in the South China Sea

International Nuclear Information System (INIS)

Liu, Songlin; Jiang, Zhijian; Zhang, Jingping; Wu, Yunchao; Lian, Zhonglian; Huang, Xiaoping

2016-01-01

To assess the effect of nutrient enrichment on the source and composition of sediment organic carbon (SOC) beneath Thalassia hemprichii and Enhalus acoroides in tropical seagrass beds, Xincun Bay, South China Sea, intertidal sediment, primary producers, and seawater samples were collected. No significant differences on sediment δ 13 C, SOC, and microbial biomass carbon (MBC) were observed between T. hemprichii and E. acoroides. SOC was mainly of autochthonous origin, while the contribution of seagrass to SOC was less than that of suspended particulate organic matter, macroalgae and epiphytes. High nutrient concentrations contributed substantially to SOC of seagrass, macroalgae, and epiphytes. The SOC, MBC, and MBC/SOC ratio in the nearest transect to fish farming were the highest. This suggested a more labile composition of SOC and shorter turnover times in higher nutrient regions. Therefore, the research indicates that nutrient enrichment could enhance plant-derived contributions to SOC and microbial use efficiency. - Highlights: • Response of sources and composition of SOC to nutrient enrichment was observed. • Similar SOC sources and composition were observed in the two seagrass communities. • Nutrient enrichment enhanced seagrass and macroalgae and epiphytes contribution to SOC. • High nutrient concentration stimulated the MBC and the MBC/SOC ratio.

High energy neutrinos from astrophysical accelerators of cosmic ray nuclei

Science.gov (United States)

Anchordoqui, Luis A.; Hooper, Dan; Sarkar, Subir; Taylor, Andrew M.

2008-02-01

.1181983223S.P.LaiJ.M.GirartR.CrutcherAstrophys. J.5982003392W.BednarekMon. Not. R. Astron. Soc.3452003847W.BednarekR.J.ProtheroeAstropart. Phys.162002397P.BlasiA.V.OlintoPhys. Rev. D591999023001F.W.SteckerAstropart. Phys.262007398F.W. Stecker, arXiv:astro-ph/0610208.A γ-ray signal from the nearby starburst galaxy NGC253 was reported by the CANGAROO-II Collaboration but their subsequent re-analysis of the data is consistent with the expectation from backgrounds:C.ItohCANGAROO-II CollaborationAstron. Astrophys.3962002L1(Erratum-ibid. 462 (2007) 67)T.A. Thompson, E. Quataert, E. Waxman, A. Loeb, arXiv:astro-ph/0608699.D.J.BirdFly’s Eye CollaborationPhys. Rev. Lett.7119933401D.R.BergmanHiRes CollaborationNucl. Phys. Proc. Suppl.136200440T.Abu-ZayyadHiRes-MIA CollaborationAstrophys. J.5572001686M.NaganoJ. Phys. G181992423V.BerezinskyA.Z.GazizovS.I.GrigorievaPhys. Rev. D742006043005R.U.AbbasiHiRes CollaborationPhys. Rev. Lett.922004151101V.BerezinskyA.Z.GazizovS.I.GrigorievaPhys. Lett. B6122005147V.S.BerezinskyS.I.GrigorievaB.I.HnatykAstropart. Phys.212004617See Fig. 21 in:L.AnchordoquiM.T.DovaA.MariazziT.McCauleyT.PaulS.ReucroftJ.SwainAnn. Phys.3142004145D.AllardE.ParizotE.KhanS.GorielyA.V.OlintoAstron. Astrophys.4432005L29D.AllardE.ParizotA.V.OlintoAstropart. Phys.27200761T.Abu-ZayyadHigh Resolution Fly’s Eye CollaborationAstropart. Phys.232005157P. Sommers, et al., Pierre Auger Collaboration, arXiv:astro-ph/0507150.R.U.AbbasiHiRes CollaborationAstrophys. J.6222005910B.N. Afanasiev, et al., Yakutsk Collaboration, in: M. Nagano (Ed.), Proceedings of the Tokyo Workshop on Techniques for the Study of the Extremely High Energy Cosmic Rays, 1993.J. Knapp, private communication.J.RanftPhys. Rev. D51199564R.S.FletcherT.K.GaisserP.LipariT.StanevPhys. Rev. D5019945710J.EngelT.K.GaisserT.StanevP.LipariPhys. Rev. D4619925013N.N.KalmykovS.S.OstapchenkoA.I.PavlovNucl. Phys. Proc. Suppl.52B19977It is important to stress that the Auger data are still at a preliminary stage and the

VizieR Online Data Catalog: Identifications of Sonneberg variables (Kinnunen+, 1999-2000)

Science.gov (United States)

Kinnunen, T.; Skiff, B. A.

2002-09-01

The list below is a continuation of a series providing accurate positions and identifications for variables appearing on the MVS charts (Hoffmeister, 1957, Mitt. Verdander. Sterne, No. 245). The variables here were first described by Hoffmeister (1949, Astron. Abh. Ergaenzungshefte z.d. Astron. Nach., 12, no. 1, A3) in the difficult-to-find ``Ergaenzungshefte'' to the Astronomische Nachrichten, and are the first group from a collection of some 1440 variables from this publication. Details about the identification procedure and table layout are contained in the first report of our series (Kinnunen & Skiff, 2000IBVS.4862....1K). We are grateful to librarians Antoinette Beiser (Lowell) and Brenda Corbin (U. S. Naval Observatory, Washington) for providing a photocopy of the Hoffmeister survey; ``bibliothecaire extraordinaire'' Suzanne Laloe (Obs. Paris-Meudon) advised on how this obscure journal should be cited. (3 data files).

Influence of different open circuit voltage tests on state of charge online estimation for lithium-ion batteries

International Nuclear Information System (INIS)

Zheng, Fangdan; Xing, Yinjiao; Jiang, Jiuchun; Sun, Bingxiang; Kim, Jonghoon; Pecht, Michael

2016-01-01

Highlights: • Two common tests for observing battery open circuit voltage performance are compared. • The temperature dependency of the OCV-SOC relationship is investigated. • Two estimators are evaluated in terms of accuracy and robustness for estimating battery SOC. • The incremental OCV test is better to predetermine the OCV-SOCs for SOC online estimation. - Abstract: Battery state of charge (SOC) estimation is a crucial function of battery management systems (BMSs), since accurate estimated SOC is critical to ensure the safety and reliability of electric vehicles. A widely used technique for SOC estimation is based on online inference of battery open circuit voltage (OCV). Low-current OCV and incremental OCV tests are two common methods to observe the OCV-SOC relationship, which is an important element of the SOC estimation technique. In this paper, two OCV tests are run at three different temperatures and based on which, two SOC estimators are compared and evaluated in terms of tracking accuracy, convergence time, and robustness for online estimating battery SOC. The temperature dependency of the OCV-SOC relationship is investigated and its influence on SOC estimation results is discussed. In addition, four dynamic tests are presented, one for estimator parameter identification and the other three for estimator performance evaluation. The comparison results show that estimator 2 (based on the incremental OCV test) has higher tracking accuracy and is more robust against varied loading conditions and different initial values of SOC than estimator 1 (based on the low-current OCV test) with regard to ambient temperature. Therefore, the incremental OCV test is recommended for predetermining the OCV-SOCs for battery SOC online estimation in BMSs.

Suppressor of cytokine signaling 1 interacts with oncogenic lymphocyte-specific protein tyrosine kinase.

Science.gov (United States)

Venkitachalam, Srividya; Chueh, Fu-Yu; Leong, King-Fu; Pabich, Samantha; Yu, Chao-Lan

2011-03-01

Lymphocyte-specific protein tyrosine kinase (Lck) plays a key role in T cell signal transduction and is tightly regulated by phosphorylation and dephosphorylation. Lck can function as an oncoprotein when overexpressed or constantly activated by mutations. Our previous studies showed that Lck-induced cellular transformation could be suppressed by enforced expression of suppressor of cytokine signaling 1 (SOCS1), a SOCS family member involved in the negative feedback control of cytokine signaling. We observed attenuated Lck kinase activity in SOCS1-expressing cells, suggesting an important role of SOCS in regulating Lck functions. It remains largely unknown whether and how SOCS proteins interact with the oncogenic Lck kinase. Here, we report that among four SOCS family proteins, SOCS1, SOCS2, SOCS3 and CIS (cytokine-inducible SH2 domain containing protein), SOCS1 has the highest affinity in binding to the oncogenic Lck kinase. We identified the positive regulatory phosphotyrosine 394 residue in the kinase domain as the key interacting determinant in Lck. Additionally, the Lck kinase domain alone is sufficient to bind SOCS1. While the SH2 domain in SOCS1 is important in its association with the oncogenic Lck kinase, other functional domains may also contribute to overall binding affinity. These findings provide important mechanistic insights into the role of SOCS proteins as tumor suppressors in cells transformed by oncogenic protein tyrosine kinases.

An Economic Analysis of Blockchains

OpenAIRE

Waelbroeck, Patrick

2018-01-01

The blockchain is a technology that goes beyond timestamping, bitcoin and secure financial transactions. The development of an ecosystem around smart connected objects will probably not happen without the blockchain (in one form or another). The blockchain opens the door to the liquification of the physical world, to the economy of real-time micro-transactions and to smart data sharing. However, it is necessary to distinguish between the different types of blockchains, especially between publ...

Perception of urge-to-cough and dyspnea in healthy smokers with decreased cough reflex sensitivity

OpenAIRE

Kanezaki, Masashi; Ebihara, Satoru; Nikkuni, Etsuhiro; Gui, Peijun; Suda, Chihiro; Ebihara, Takae; Yamasaki, Miyako; Kohzuki, Masahiro

2010-01-01

Background Although cigarette smoking has been implicated as an important risk factor for the development of respiratory symptoms, the perceptional aspects of two symptoms in smokers have not been fully elucidated. Therefore, we simultaneously evaluated the cough reflex sensitivity, the cognition of urge-to-cough and perception of dyspnea in both healthy smokers and non-smokers. Methods Fourteen male healthy never-smokers and 14 age-matched male healthy current-smokers were recruited via publ...

Management interventions as conditions for motivation crowding of motivation in the European commission : a mediational analysis of basic needs satisfaction. Paper

OpenAIRE

Vandenabeele, W.V.

2009-01-01

Motivation of employees is crucial to achieve results within any organization, be it a public or a private organization (Rainey and Steinbauer 1999; Kojasteh 1993). It therefore can be considered to be one of the big questions in current public administration research (Behn 1995). Despite its importance, motivation is not easily grasped, being a multi-faceted and dynamic phenomenon. Nevertheless, recent efforts have provided openings to more fully understand the motivational processes of publ...

Environmental Impact Research Program. Yellow Sweetclover (Melilotus officinalis) Section 7.3.4, U.S. Army Corps of Engineers Wildlife Resources Management Manual.

Science.gov (United States)

1986-07-01

Nevada Mountains (Short 1943, Pickford and Jackman 1944, Cornelius and Talbot 1955, Hull and Johnson 1955, Lavin and Springfield 1955). Yellow...sodbound pastures (Peterson and Hughes 1947). Mixed with red clover (Trifolium pratense) and alsike clover (T. hybridum), it is used to renovate...American Wildlife and 07 Plants. Dover Publ., Inc., New York. 500 pp. U.5 |1 Peterson, H. L., and H. D. Hughes . 1947. Let’s remodel our pastures. Iowa Farm

Tropical Timbers of the World,

Science.gov (United States)

1980-04-01

Trop. Woods No. 103:1-139. 96 CORDIA SPP. (HAI0-XWlED, DARK- aW CERASCMAUS (BLiP) CANALETE Family: Boraginaceae Other Common Names: Anacahuite, Barfa...tropicaux. Premier Suppl~ment. Publ. Centre Tech. For. Trop. No. 23. 372 Lf4 CORDIA MILLNII and C. PLAT’IYRSA WEST AFRICAN CORDIA Family: Boraginaceae...OE AM Hibiscus elacus and H. tiliaceus BLUEGUM AS Eucalyptus globulus BOCOTE AM Cordia spp. (Hard-wooded, dark-colored Gerascanthus group) BOMBAY

Seagrass Control Project: Containment Boom Evaluation. A Method to Protect Seawater Intakes from Seagrass Accumulation.

Science.gov (United States)

1983-10-01

containment booms at other mooring sites with significantly different physical and environ- mental conditions is recommended before full-scale application...deployment pattern for the different ship types. Modified procedures may also be needed to deploy the boom under a different set of physical and environmental... STPM Press Publ. New York, 353pp. 1980. Pulich, W., S. Barnes and P. Parker. Trace metal cycles in seagrass communities. pp 493-506 in M. Wiley, ed

Corporate social responsibility reporting: The case of Portuguese hospitals

OpenAIRE

Oliveira, Joana Nicolau

2012-01-01

A Work Project, presented as part of the requirements for the Award of a Masters Degree in Management from the NOVA – School of Business and Economics This research investigated Portuguese Hospitals’ Corporate Social Responsibility reporting practices, by analyzing Hospitals’ Annual Reports and websites. The main hospital stakeholders were presented and activities pertaining to each group included. Overall, it appears that there is a lack of strategic CSR reporting on both private and publ...

First record of the megatoothed shark Carcharocles megalodon from the Mio-Pliocene Purisima Formation of Northern California.

OpenAIRE

Boessenecker, Robert W.

2016-01-01

Megatoothed sharks (Family: Otodontidae) are among the most widely reported sharks in Cenozoic marine sediments worldwide, and certain species such as the famed Carcharocles megalodon are particularly abundant in Neogene deposits on the Atlantic margin of the United States. Cenozoic marine strata on the Pacific margin of North America have yielded one of the most densely sampled marine vertebrate records anywhere, but published occurrences of shark assemblages are uncommon. Rarer yet are publ...

Production-logistic system in the aspect of strategies for production planning and control and for logistic customer service

OpenAIRE

Łukasz Hadaś; Agnieszka Stachowiak; Piotr Cyplik

2014-01-01

Background: The authors made multi-dimensional review of production and logistic strategies in order to prove their coherence in shaping internal and external supply chain. The paper is concluded with definition of production-logistic system as an object of modeling in transformation of business systems of manufacturing companies. Material and methods: The paper is based on analysis of state of the art presented in the literature on the subject of production and logistics strategies. Publ...

A Study on the Bionomics of Anopheles darlingi Root (Diptera: Culicidae) in Belize, Central America

Science.gov (United States)

2004-03-01

Mosquitoes of medical importance. U.S. Dep. Agric. Agric. Handb. 152. Forattini, O.P. 1962. Entomologia medica vol. I. Faculdade de Higiene e Saude Publica...meridional do Brasil. Rev. Saude Publ., S. Paulo. 21: 291-304. Forattini, O.P. 1962. Entomologia medica vol. I. Faculdade de Higiene e Saude...152. Forattini, O.P. 1962. Entomologia medica vol. I. Faculdade de Higiene e Saude Publica, Sao Paulo, Brazil. 662 pp. Grieco, J.P. 2001. The

Legitieme Modekritiek - Legitieme mode? Moderecensies in kwaliteitskranten

OpenAIRE

Aurélie van de Peer

2013-01-01

Fashion journalism is often viewed as unsuited to the role of legitimate cultural criticism. The present article sees two recurring motivations for this observation: the fashion press' strong dependence on fashion advertising income and a long-standing tradition that rejects the transient temporality of fashion in which journalistic accounts of fashion often take part. These observations are probed for the genre of high-quality daily newspapers, drawing on a case-study of fashion reviews publ...

The Solar Cycle Variation of Coronal Temperature and Density During Cycle 21-22

Science.gov (United States)

1994-06-15

We notice that a dramatic change in the intensity ratio implies a small change in temperature and therefore the precise calibration of each...The higher temperature material of these zones tends to lie over regions where magnetograph observations indicate a change in polarity of weak large...SPIE, 331,442, 1982. 7. Altrock, LC., Clmate Impact of Solar Variability Greenbelt, MD, NASA Conf. Publ. 3086, p. 287, 1990. 8. Fisher, LRL., McCabe, M

Comparing Active Auditors viewpoints in Public and Private Sector over Determining Basic Materiality Levels in Auditing

OpenAIRE

Ali Asghar Farajzadeh; Tahereh Azizzadeh

2012-01-01

Materiality is a threshold quality in accounting which has priority over other qualitative characteristics of financial information. In other word, financial information are important in decision-making only when they are important with respect to this to definition, omission or altering these significant information can change the judgments and decisions of logical user over the affairs of a business entity. The purpose of this research was to identify the auditors` ideas in private and publ...

Health Services Approach to the Communication Audit

OpenAIRE

Tereza Balcarová

2014-01-01

This paper deals with the use of a communication audit as a tool for evaluating the effectiveness of public relations within health services. The research was conducted within healthcare institutions operating in the Czech Republic. Areas of research questions were focused on these aspects of health services: The approach to the implementation of a communication audit: Is the communication audit tied to the level of public relations effectiveness evaluation? Is the approach influenced by publ...

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Indian Academy of Sciences (India)

S. Seetha

variety of celestial sources, using satellite-based astron- ... India's first dedicated astronomy satellite –. Astrosat, is ... pose for and study different types of target sources of scientific interest ... lite after launch is provided in the last article. In order ...

Knowledge Architect : A Tool Suite for Managing Software Architecture Knowledge

NARCIS (Netherlands)

Liang, Peng; Jansen, Anton; Avgeriou, Paris

2009-01-01

Management of software architecture knowledge (AK) is vital for improving an organization’s architectural capabilities. To support the architecting process within our industrial partner: Astron, the Dutch radio astronomy institute, we implemented the Knowledge Architect (KA): a tool suite for

Vent Complexes above Dolerite Sills in Phanerozoic LIPs: Implications for Proterozoic LIPs and IOCG Deposits

Science.gov (United States)

Ernst, R. E.; Bleeker, W.; Svensen, H.; Planke, S.; Polozov, A. G.

2009-05-01

side of Great Bear Lake [11], be the cause of both the Wernecke Breccias of the Yukon (with their hematite, Cu, Co, U and Au mineralization) and the Olympic Dam giant IOCG deposit of the Gawler craton of Australia, which was probably an adjacent block at this time [12, 11]? A dramatic expansion of new targets for IOCGs potentially could be achieved via a systematic survey of sill provinces associated with Proterozoic and Paleozoic LIPs from around the world, with a special focus on those in which the host sediments are evaporate-rich, with the goal of identifying mineralized HVCs. [1] Hitzman, 2000, In: Porter (ed.) v.1; PGC Publishing; [2] Williams et al., 2005, Econ. Geol; [3] Corriveau, 2007, GAC Min. Dep. Div. Spec. Pub 5; [4] Jamtveit et al., 2004, In: Geol. Soc. London, Spec. Publ. 234; [5] Planke et al., 2005, In: Dore & Vining (eds) Geol. Soc. London; [6] Svensen et al., 2006, J. Geol. Soc. London; [7] Svensen et al., 2008, EPSL; [8] Buchan & Ernst, 2004 GSC. Map 2022A; [9] Jefferson et al., 1994, GSC. OF 2789; [10] Rainbird, 1998, GSC OF File 3671; [11] Hamilton & Buchan 2007, GSA Ann. Mtg ; [12] Thorkelson et al., 2001, Prec. Res.

Conversion of lowland tropical forests to tree cash crop plantations loses up to one-half of stored soil organic carbon.

Science.gov (United States)

van Straaten, Oliver; Corre, Marife D; Wolf, Katrin; Tchienkoua, Martin; Cuellar, Eloy; Matthews, Robin B; Veldkamp, Edzo

2015-08-11

Tropical deforestation for the establishment of tree cash crop plantations causes significant alterations to soil organic carbon (SOC) dynamics. Despite this recognition, the current Intergovernmental Panel on Climate Change (IPCC) tier 1 method has a SOC change factor of 1 (no SOC loss) for conversion of forests to perennial tree crops, because of scarcity of SOC data. In this pantropic study, conducted in active deforestation regions of Indonesia, Cameroon, and Peru, we quantified the impact of forest conversion to oil palm (Elaeis guineensis), rubber (Hevea brasiliensis), and cacao (Theobroma cacao) agroforestry plantations on SOC stocks within 3-m depth in deeply weathered mineral soils. We also investigated the underlying biophysical controls regulating SOC stock changes. Using a space-for-time substitution approach, we compared SOC stocks from paired forests (n = 32) and adjacent plantations (n = 54). Our study showed that deforestation for tree plantations decreased SOC stocks by up to 50%. The key variable that predicted SOC changes across plantations was the amount of SOC present in the forest before conversion--the higher the initial SOC, the higher the loss. Decreases in SOC stocks were most pronounced in the topsoil, although older plantations showed considerable SOC losses below 1-m depth. Our results suggest that (i) the IPCC tier 1 method should be revised from its current SOC change factor of 1 to 0.6 ± 0.1 for oil palm and cacao agroforestry plantations and 0.8 ± 0.3 for rubber plantations in the humid tropics; and (ii) land use management policies should protect natural forests on carbon-rich mineral soils to minimize SOC losses.

Conversion of lowland tropical forests to tree cash crop plantations loses up to one-half of stored soil organic carbon

Science.gov (United States)

van Straaten, Oliver; Corre, Marife D.; Wolf, Katrin; Tchienkoua, Martin; Cuellar, Eloy; Matthews, Robin B.; Veldkamp, Edzo

2015-01-01

Tropical deforestation for the establishment of tree cash crop plantations causes significant alterations to soil organic carbon (SOC) dynamics. Despite this recognition, the current Intergovernmental Panel on Climate Change (IPCC) tier 1 method has a SOC change factor of 1 (no SOC loss) for conversion of forests to perennial tree crops, because of scarcity of SOC data. In this pantropic study, conducted in active deforestation regions of Indonesia, Cameroon, and Peru, we quantified the impact of forest conversion to oil palm (Elaeis guineensis), rubber (Hevea brasiliensis), and cacao (Theobroma cacao) agroforestry plantations on SOC stocks within 3-m depth in deeply weathered mineral soils. We also investigated the underlying biophysical controls regulating SOC stock changes. Using a space-for-time substitution approach, we compared SOC stocks from paired forests (n = 32) and adjacent plantations (n = 54). Our study showed that deforestation for tree plantations decreased SOC stocks by up to 50%. The key variable that predicted SOC changes across plantations was the amount of SOC present in the forest before conversion—the higher the initial SOC, the higher the loss. Decreases in SOC stocks were most pronounced in the topsoil, although older plantations showed considerable SOC losses below 1-m depth. Our results suggest that (i) the IPCC tier 1 method should be revised from its current SOC change factor of 1 to 0.6 ± 0.1 for oil palm and cacao agroforestry plantations and 0.8 ± 0.3 for rubber plantations in the humid tropics; and (ii) land use management policies should protect natural forests on carbon-rich mineral soils to minimize SOC losses. PMID:26217000

Mechanism of inhibition of growth hormone receptor signaling by suppressor of cytokine signaling proteins

DEFF Research Database (Denmark)

Hansen, J A; Lindberg, K; Hilton, D J

1999-01-01

In this study we have investigated the role of suppressor of cytokine signaling (SOCS) proteins in GH receptor-mediated signaling. GH-induced transcription was inhibited by SOCS-1 and SOCS-3, while SOCS-2 and cytokine inducible SH2-containing protein (CIS) had no effect By using chimeric SOCS pro...

in Human Liver Diseases

Directory of Open Access Journals (Sweden)

Minoru Fujimoto

2010-01-01

Full Text Available Toll-like receptor (TLR signaling pathways are strictly coordinated by several mechanisms to regulate adequate innate immune responses. Recent lines of evidence indicate that the suppressor of cytokine signaling (SOCS family proteins, originally identified as negative-feedback regulators in cytokine signaling, are involved in the regulation of TLR-mediated immune responses. SOCS1, a member of SOCS family, is strongly induced upon TLR stimulation. Cells lacking SOCS1 are hyperresponsive to TLR stimulation. Thus, SOCS1 is an important regulator for both cytokine and TLR-induced responses. As an immune organ, the liver contains various types of immune cells such as T cells, NK cells, NKT cells, and Kupffer cells and is continuously challenged with gut-derived bacterial and dietary antigens. SOCS1 may be implicated in pathophysiology of the liver. The studies using SOCS1-deficient mice revealed that endogenous SOCS1 is critical for the prevention of liver diseases such as hepatitis, cirrhosis, and cancers. Recent studies on humans suggest that SOCS1 is involved in the development of various liver disorders in humans. Thus, SOCS1 and other SOCS proteins are potential targets for the therapy of human liver diseases.

Spatial variability of soil carbon stock in the Urucu river basin, Central Amazon-Brazil

International Nuclear Information System (INIS)

Ceddia, Marcos Bacis; Villela, André Luis Oliveira; Pinheiro, Érika Flávia Machado; Wendroth, Ole

2015-01-01

The Amazon Forest plays a major role in C sequestration and release. However, few regional estimates of soil organic carbon (SOC) stock in this ecoregion exist. One of the barriers to improve SOC estimates is the lack of recent soil data at high spatial resolution, which hampers the application of new methods for mapping SOC stock. The aims of this work were: (i) to quantify SOC stock under undisturbed vegetation for the 0–30 and the 0–100 cm under Amazon Forest; (ii) to correlate the SOC stock with soil mapping units and relief attributes and (iii) to evaluate three geostatistical techniques to generate maps of SOC stock (ordinary, isotopic and heterotopic cokriging). The study site is located in the Central region of Amazon State, Brazil. The soil survey covered the study site that has an area of 80 km 2 and resulted in a 1:10,000 soil map. It consisted of 315 field observations (96 complete soil profiles and 219 boreholes). SOC stock was calculated by summing C stocks by horizon, determined as a product of BD, SOC and the horizon thickness. For each one of the 315 soil observations, relief attributes were derived from a topographic map to understand SOC dynamics. The SOC stocks across 30 and 100 cm soil depth were 3.28 and 7.32 kg C m −2 , respectively, which is, 34 and 16%, lower than other studies. The SOC stock is higher in soils developed in relief forms exhibiting well-drained soils, which are covered by Upland Dense Tropical Rainforest. Only SOC stock in the upper 100 cm exhibited spatial dependence allowing the generation of spatial variability maps based on spatial (co)-regionalization. The CTI was inversely correlated with SOC stock and was the only auxiliary variable feasible to be used in cokriging interpolation. The heterotopic cokriging presented the best performance for mapping SOC stock. - Highlights: • The SOC stocks across 30 and 100 cm depth were 3.28 and 7.32 kg C m −2 , respectively. • SOC stocks were 34 and 16%, respectively

Associations between maternal sense of coherence and controlling feeding practices: The importance of resilience and support in families of preschoolers.

Science.gov (United States)

Eli, Karin; Sorjonen, Kimmo; Mokoena, Lincoln; Pietrobelli, Angelo; Flodmark, Carl-Erik; Faith, Myles S; Nowicka, Paulina

2016-10-01

Sense of Coherence (SOC) measures an individual's positive, or salutogenic, orientation toward her/his capacities, environment, future, and life. SOC comprises three factors: comprehensibility (the sense of one's own life as ordered and understandable); manageability (the perception of available resources and skills to manage stressors); and meaningfulness (the overall sense that life is filled with meaning and purpose). In numerous studies, SOC has been associated with resilience to stress. However, associations between parental SOC and controlling feeding practices have yet to be studied. This study examines the validity of the SOC 13-item, 3-factor questionnaire, associations between SOC and maternal and child characteristics, and associations between SOC and use of pressuring or restrictive feeding, among mothers of 4-year-olds. 565 mothers (23.5% of foreign origin, 30.3% with overweight/obesity) recruited via the Swedish population registry (response rate: 65%), completed the SOC-13, the Child Feeding Questionnaire (CFQ), and a background questionnaire. The validity of SOC-13 was examined using confirmatory factor analysis; associations with background characteristics and feeding practices were tested with structural equation modeling. SOC-13 validity testing showed acceptable fit (TLI = 0.93, CFI = 0.94, RMSEA = 0.06, SRMR = 0.04) after allowing one pair of error terms to correlate. The Cronbach's alpha for meaningfulness was 0.73, comprehensibility 0.76, and manageability 0.75. SOC increased with mothers' Swedish background and education, and decreased with higher BMI. Child gender, age, and BMI, were not associated with SOC. Lower SOC was associated with controlling practices and with concern about child weight and eating. The associations between SOC and feeding suggest that SOC-related parameters could inform childhood obesity research, and that prevention should address the socioeconomic barriers that parents face in building resilience to stress

Texture and organic carbon contents do not impact amount of carbon protected in Malagasy soils

Directory of Open Access Journals (Sweden)

Tantely Razafimbelo

2013-06-01

Full Text Available Soil organic carbon (SOC is usually said to be well correlated with soil texture and soil aggregation. These relations generally suggest a physical and physicochemical protection of SOC within soil aggregates and on soil fine particles, respectively. Because there are few experimental evidences of these relations on tropical soils, we tested the relations of soil variables (SOC and soil aggregate contents, and soil texture with the amount of SOC physically protected in aggregates on a set of 15 Malagasy soils. The soil texture, the SOC and water stable macroaggregate (MA contents and the amount of SOC physically protected inside aggregates, calculated as the difference of C mineralized by crushed and intact aggregates, were characterized. The relation between these variables was established. SOC content was significantly correlated with soil texture (clay+fine silt fraction and with soil MA amount while protected SOC content was not correlated with soil MA amount. This lack of correlation might be attributed to the highest importance of physicochemical protection of SOC which is demonstrated by the positive relation between SOC and clay+fine silt fraction.

Spectroscopic Variability of Supergiant Star HD14134, B3Ia

Indian Academy of Sciences (India)

Y. M. Maharramov

2017-06-19

Jun 19, 2017 ... the hot supergiant HD14134 studied in the present paper has a mass-loss rate of ...... tific program for the priority fields of research of the. National .... emission-line stars in the Large Magellanic Cloud, Astron. Astrophys., 158 ...

Gravitational lensing statistics with extragalactic surveys; 2, Analysis of the Jodrell Bank-VLA Astrometric Survey

NARCIS (Netherlands)

Helbig, P.; Marlow, D. R.; Quast, R.; Wilkinson, P. N.; Browne, I. W. A.; Koopmans, L. V. E.

1999-01-01

Published in: Astron. Astrophys. Suppl. Ser. 136 (1999) no. 2, pp.297-305 citations recorded in [Science Citation Index] Abstract: We present constraints on the cosmological constant $lambda_{0}$ from gravitational lensing statistics of the Jodrell Bank-VLA Astrometric Survey (JVAS). Although this

A comparative study of three model-based algorithms for estimating state-of-charge of lithium-ion batteries under a new combined dynamic loading profile

International Nuclear Information System (INIS)

Yang, Fangfang; Xing, Yinjiao; Wang, Dong; Tsui, Kwok-Leung

2016-01-01

Highlights: • Three different model-based filtering algorithms for SOC estimation are compared. • A combined dynamic loading profile is proposed to evaluate the three algorithms. • Robustness against uncertainty of initial states of SOC estimators are investigated. • Battery capacity degradation is considered in SOC estimation. - Abstract: Accurate state-of-charge (SOC) estimation is critical for the safety and reliability of battery management systems in electric vehicles. Because SOC cannot be directly measured and SOC estimation is affected by many factors, such as ambient temperature, battery aging, and current rate, a robust SOC estimation approach is necessary to be developed so as to deal with time-varying and nonlinear battery systems. In this paper, three popular model-based filtering algorithms, including extended Kalman filter, unscented Kalman filter, and particle filter, are respectively used to estimate SOC and their performances regarding to tracking accuracy, computation time, robustness against uncertainty of initial values of SOC, and battery degradation, are compared. To evaluate the performances of these algorithms, a new combined dynamic loading profile composed of the dynamic stress test, the federal urban driving schedule and the US06 is proposed. The comparison results showed that the unscented Kalman filter is the most robust to different initial values of SOC, while the particle filter owns the fastest convergence ability when an initial guess of SOC is far from a true initial SOC.

Effect of nutrient enrichment on the source and composition of sediment organic carbon in tropical seagrass beds in the South China Sea.

Science.gov (United States)

Liu, Songlin; Jiang, Zhijian; Zhang, Jingping; Wu, Yunchao; Lian, Zhonglian; Huang, Xiaoping

2016-09-15

To assess the effect of nutrient enrichment on the source and composition of sediment organic carbon (SOC) beneath Thalassia hemprichii and Enhalus acoroides in tropical seagrass beds, Xincun Bay, South China Sea, intertidal sediment, primary producers, and seawater samples were collected. No significant differences on sediment δ(13)C, SOC, and microbial biomass carbon (MBC) were observed between T. hemprichii and E. acoroides. SOC was mainly of autochthonous origin, while the contribution of seagrass to SOC was less than that of suspended particulate organic matter, macroalgae and epiphytes. High nutrient concentrations contributed substantially to SOC of seagrass, macroalgae, and epiphytes. The SOC, MBC, and MBC/SOC ratio in the nearest transect to fish farming were the highest. This suggested a more labile composition of SOC and shorter turnover times in higher nutrient regions. Therefore, the research indicates that nutrient enrichment could enhance plant-derived contributions to SOC and microbial use efficiency. Copyright © 2016 Elsevier Ltd. All rights reserved.

Microbe-driven turnover offsets mineral-mediated storage of soil carbon under elevated CO2

Science.gov (United States)

Sulman, Benjamin N.; Phillips, Richard P.; Oishi, A. Christopher; Shevliakova, Elena; Pacala, Stephen W.

2014-12-01

The sensitivity of soil organic carbon (SOC) to changing environmental conditions represents a critical uncertainty in coupled carbon cycle-climate models. Much of this uncertainty arises from our limited understanding of the extent to which root-microbe interactions induce SOC losses (through accelerated decomposition or `priming') or indirectly promote SOC gains (via `protection' through interactions with mineral particles). We developed a new SOC model to examine priming and protection responses to rising atmospheric CO2. The model captured disparate SOC responses at two temperate free-air CO2 enrichment (FACE) experiments. We show that stabilization of `new' carbon in protected SOC pools may equal or exceed microbial priming of `old' SOC in ecosystems with readily decomposable litter and high clay content (for example, Oak Ridge). In contrast, carbon losses induced through priming dominate the net SOC response in ecosystems with more resistant litters and lower clay content (for example, Duke). The SOC model was fully integrated into a global terrestrial carbon cycle model to run global simulations of elevated CO2 effects. Although protected carbon provides an important constraint on priming effects, priming nonetheless reduced SOC storage in the majority of terrestrial areas, partially counterbalancing SOC gains from enhanced ecosystem productivity.

Distribution functions for a family of general-relativistic hypervirial models in the collisionless regime

Science.gov (United States)

Gauy, Henrique Matheus; Ramos-Caro, Javier

2018-03-01

By considering the Einstein-Vlasov system for static spherically symmetric distributions of matter, we show that configurations with constant anisotropy parameter β , leading to asymptotically flat spacetimes, have necessarily a distribution function (DF) of the form F =l-2 βξ (ɛ ) , where ɛ =E /m and l =L /m are the relativistic energy and angular momentum per unit rest mass, respectively. We exploit this result to obtain DFs for the general relativistic extension of the hypervirial family introduced by Nguyen and Lingam [Mon. Not. R. Astron. Soc. 436, 2014 (2013), 10.1093/mnras/stt1719], which Newtonian potential is given by ϕ (r )=-ϕo/[1 +(r /a )n]1 /n (a and ϕo are positive free parameters, n =1 ,2 ,… ). Such DFs can be written in the form Fn=ln -2ξn(ɛ ) . For odd n , we find that ξn is a polynomial of order 2 n +1 in ɛ , as in the case of the Hernquist model (n =1 ), for which F1∝l-1(2 ɛ -1 ) (ɛ-1 ) 2 . For even n , we can write ξn in terms of incomplete beta functions (Plummer model, n =2 , is an example). Since we demand that F ≥0 throughout the phase space, the particular form of each ξn leads to restrictions for the values of ϕo. For example, for the Hernquist model we find that 0 ≤ϕo≤2 /3 , i.e., an upper bounding value less than the one obtained for Nguyen and Lingam (0 ≤ϕo≤1 ), based on energy conditions.

Quasi-biennial modulation of solar neutrino flux: connections with solar activity

Science.gov (United States)

Vecchio, A.; Laurenza, M.; D'alessi, L.; Carbone, V.; Storini, M.

2011-12-01

A quasi-biennial periodicity has been recently found (Vecchio et al., 2010) in the solar neutrino flux, as detected at the Homestake experiment, as well as in the flux of solar energetic protons, by means of the Empirical Modes Decomposition technique. Moreover, both fluxes have been found to be significantly correlated at the quasi-biennial timescale, thus supporting the hypothesis of a connection between solar neutrinos and solar activity. The origin of this connection is investigated, by modeling how the standard Mikheyev-Smirnov-Wolfenstein (MSW) effect (the process for which the well-known neutrino flavor oscillations are modified in passing through the material) could be influenced by matter fluctuations. As proposed by Burgess et al., 2004, by introducing a background magnetic field in the helioseismic model, density fluctuations can be excited in the radiative zone by the resonance between helioseismic g-modes and Alfvén waves. In particular, with reasonable values of the background magnetic field (10-100 kG), the distance between resonant layers could be of the same order of neutrino oscillation length. We study the effect over this distance of a background magnetic field which is variable with a ~2 yr period, in agreement with typical variations of solar activity. Our findings suggest that the quasi-biennial modulation of the neutrino flux is theoretically possible as a consequence of the magnetic field variations in the solar interior. A. Vecchio, M. Laurenza, V. Carbone, M. Storini, The Astrophysical Journal Letters, 709, L1-L5 (2010). C. Burgess, N. S. Dzhalilov, T. I. Rashba, V., B.Semikoz, J. W. F. Valle, Mon. Not. R. Astron. Soc., 348, 609-624 (2004).

Metrics in Keplerian orbits quotient spaces

Science.gov (United States)

Milanov, Danila V.

2018-03-01

Quotient spaces of Keplerian orbits are important instruments for the modelling of orbit samples of celestial bodies on a large time span. We suppose that variations of the orbital eccentricities, inclinations and semi-major axes remain sufficiently small, while arbitrary perturbations are allowed for the arguments of pericentres or longitudes of the nodes, or both. The distance between orbits or their images in quotient spaces serves as a numerical criterion for such problems of Celestial Mechanics as search for common origin of meteoroid streams, comets, and asteroids, asteroid families identification, and others. In this paper, we consider quotient sets of the non-rectilinear Keplerian orbits space H. Their elements are identified irrespective of the values of pericentre arguments or node longitudes. We prove that distance functions on the quotient sets, introduced in Kholshevnikov et al. (Mon Not R Astron Soc 462:2275-2283, 2016), satisfy metric space axioms and discuss theoretical and practical importance of this result. Isometric embeddings of the quotient spaces into R^n, and a space of compact subsets of H with Hausdorff metric are constructed. The Euclidean representations of the orbits spaces find its applications in a problem of orbit averaging and computational algorithms specific to Euclidean space. We also explore completions of H and its quotient spaces with respect to corresponding metrics and establish a relation between elements of the extended spaces and rectilinear trajectories. Distance between an orbit and subsets of elliptic and hyperbolic orbits is calculated. This quantity provides an upper bound for the metric value in a problem of close orbits identification. Finally the invariance of the equivalence relations in H under coordinates change is discussed.

Anisotropic extinction distortion of the galaxy correlation function

International Nuclear Information System (INIS)

Fang Wenjuan; Hui Lam; Menard, Brice; May, Morgan; Scranton, Ryan

2011-01-01

Similar to the magnification of the galaxies' fluxes by gravitational lensing, the extinction of the fluxes by comic dust, whose existence is recently detected by [B. Menard, R. Scranton, M. Fukugita, and G. Richards, Mon. Not. R. Astron. Soc. 405, 1025 (2010).], also modifies the distribution of a flux-selected galaxy sample. We study the anisotropic distortion by dust extinction to the 3D galaxy correlation function, including magnification bias and redshift distortion at the same time. We find the extinction distortion is most significant along the line of sight and at large separations, similar to that by magnification bias. The correction from dust extinction is negative except at sufficiently large transverse separations, which is almost always opposite to that from magnification bias (we consider a number count slope s>0.4). Hence, the distortions from these two effects tend to reduce each other. At low z (< or approx. 1), the distortion by extinction is stronger than that by magnification bias, but at high z, the reverse holds. We also study how dust extinction affects probes in real space of the baryon acoustic oscillations (BAO) and the linear redshift distortion parameter β. We find its effect on BAO is negligible. However, it introduces a positive scale-dependent correction to β that can be as large as a few percent. At the same time, we also find a negative scale-dependent correction from magnification bias, which is up to percent level at low z, but to ∼40% at high z. These corrections are non-negligible for precision cosmology, and should be considered when testing General Relativity through the scale-dependence of β.

Dynamics of soil organic carbon in density fractions during post-agricultural succession over two lithology types, southwest China.

Science.gov (United States)

Wen, Li; Li, Dejun; Chen, Hao; Wang, Kelin

2017-10-01

Agricultural abandonment has been proposed as an effective way to enhance soil organic carbon (SOC) sequestration. Nevertheless, SOC sequestration in the long term is largely determined by whether the stable SOC fractions will increase. Here the dynamics of SOC fractions during post-agricultural succession were investigated in a karst region, southwest China using a space-for-time substitution approach. Cropland, grassland, shrubland and secondary forest were selected from areas underlain by dolomite and limestone, respectively. Density fractionation was used to separate bulk SOC into free light fraction (FLFC) and heavy fraction (HFC). FLFC contents were similar over dolomite and limestone, but bulk SOC and HFC contents were greater over limestone than over dolomite. FLFC content in the forest was greater than in the other vegetation types, but bulk SOC and HFC contents increased from the cropland through to the forest for areas underlain by dolomite. The contents of bulk SOC and its fractions were similar among the four vegetation types over limestone. The proportion of FLFC in bulk SOC was higher over dolomite than over limestone, but the case was inverse for the proportion of HFC, indicating SOC over limestone was more stable. However, the proportions of both FLFC and HFC were similar among the four vegetation types, implying that SOC stability was not changed by cropland conversion. Exchangeable calcium explained most of the variance of HFC content. Our study suggests that lithology not only affects SOC content and its stability, but modulates the dynamics of SOC fractions during post-agricultural succession. Copyright © 2017 Elsevier Ltd. All rights reserved.

The Public-Private Sector Wage Differential: Gender, Workplaces and Family Friendliness

OpenAIRE

Monojit Chatterji; Karen Mumford; Peter N Smith

2007-01-01

This study examines the role of individual characteristics, occupation, and workplace features accounting for differences in hourly earnings between male and female fulltime employees in the public and private sectors. Using new linked employeeemployer data for Britain in 2004, we find that the nature of the public private pay gap differs between genders and that of the gender pay gap differs between sectors. The analysis shows that essentially none of the gender earnings gap in both the publ...

Taxonomic Evaluation of Cleveland Harbor Lake Areas

Science.gov (United States)

2014-01-01

collected using a standard (8.2-L) stainless steel ponar grab (229 x 229 mm) in basic accordance with USEPA (2001). The grab sampler was dropped from...through stacked 1.0- and 0.5-mm stainless steel sieves to separate coarse and fine material. Sample material retained in both sieves was thoroughly... 416 . Berry, E. 1943. The Amnicolidae of Michigan: Distribution, ecology, and taxonomy. Misc. Publ. Mus. Zool. U. Mich. 57:1-68. Dillon, R. T., Jr

Sinergitas Stakeholders Dalam Pengelolaan Sampah Terpadu Untuk Administrasi Publik Yang Demokratis Dalam Perspektif Teori Governance (Studi Pada Tempat Pengelolaan Sampah Terpadu Mulyoagung Bersatu Kecamatan DAU Kabupaten Malang)

OpenAIRE

Aditya, Bayu Rizky

2014-01-01

: Sinergy of Stakeholders in Integrated Waste Management for Democratic Public Administration in the Perspective Governance Theory (Study on Integrated Waste Management Mulyoagung Bersatu Kecamatan Dau Kabupaten Malang) This research was conducted based on the number of services provided by the government to the people are still the concept of Top-Down, which is issued by a government policy without seeing what was needed and required by society, even most of the services provided to the publ...

A Unique Case of Muscle Invasive Metastatic Breast Cancer Mimicking Myositis

Science.gov (United States)

2017-06-28

TYPE 08/ 03/20 17 Publ ication/Journal 4. TITLE AND SUBTITLE A unique case of muscle-invasive metastatic breast cancer mimicking myositis 6...Rev. 8/98) Prescnbed by ANSI Std Z39. 18 Adobe Profes11on11 7.0 Title: A Unique Case of M uscle-Invasive Metastatic Breast Cancer M imicking...an 84-year-old female who presented with neck swelling and upper airway obstruction due to metastatic breast cancer invading the sternocleidomastoid

Final Report on Scientific Activities Pursuant to the Provisions of AFOSR Grant 79-0018-A during the Period November 1, 1982 to October 31, 1983.

Science.gov (United States)

1983-10-31

known that certain families of entire functions may be given a Hilbert space structure. (See, in particular, the extensive work [Al of de Branges in...and the other, related, spa- ces described by de Branges , the spaces T which we introduce as dual spaces to 0 are intimately connected with certain...Functions", translated from the Romanian by G. Bernstein and E. Tomer, Interscience Publ. Co., New York, 1968. [3] De Branges , L.: "Hilbert Spaces of Entire

Spatial variability of soil carbon stock in the Urucu river basin, Central Amazon-Brazil

Energy Technology Data Exchange (ETDEWEB)

Ceddia, Marcos Bacis, E-mail: marcosceddia@gmail.com [Department of Soil, Institute of Agronomy, Universidade Federal Rural do Rio de Janeiro (UFRRJ), Seropédica, RJ 23890-000 (Brazil); Villela, André Luis Oliveira [Colégio Técnico da UFRRJ, RJ, Seropédica 23890-000 (Brazil); Pinheiro, Érika Flávia Machado [Department of Soil, Institute of Agronomy, Universidade Federal Rural do Rio de Janeiro (UFRRJ), Seropédica, RJ 23890-000 (Brazil); Wendroth, Ole [Department of Plant & Soil Sciences, University of Kentucky, College of Agriculture, Lexington, KY (United States)

2015-09-01

The Amazon Forest plays a major role in C sequestration and release. However, few regional estimates of soil organic carbon (SOC) stock in this ecoregion exist. One of the barriers to improve SOC estimates is the lack of recent soil data at high spatial resolution, which hampers the application of new methods for mapping SOC stock. The aims of this work were: (i) to quantify SOC stock under undisturbed vegetation for the 0–30 and the 0–100 cm under Amazon Forest; (ii) to correlate the SOC stock with soil mapping units and relief attributes and (iii) to evaluate three geostatistical techniques to generate maps of SOC stock (ordinary, isotopic and heterotopic cokriging). The study site is located in the Central region of Amazon State, Brazil. The soil survey covered the study site that has an area of 80 km{sup 2} and resulted in a 1:10,000 soil map. It consisted of 315 field observations (96 complete soil profiles and 219 boreholes). SOC stock was calculated by summing C stocks by horizon, determined as a product of BD, SOC and the horizon thickness. For each one of the 315 soil observations, relief attributes were derived from a topographic map to understand SOC dynamics. The SOC stocks across 30 and 100 cm soil depth were 3.28 and 7.32 kg C m{sup −2}, respectively, which is, 34 and 16%, lower than other studies. The SOC stock is higher in soils developed in relief forms exhibiting well-drained soils, which are covered by Upland Dense Tropical Rainforest. Only SOC stock in the upper 100 cm exhibited spatial dependence allowing the generation of spatial variability maps based on spatial (co)-regionalization. The CTI was inversely correlated with SOC stock and was the only auxiliary variable feasible to be used in cokriging interpolation. The heterotopic cokriging presented the best performance for mapping SOC stock. - Highlights: • The SOC stocks across 30 and 100 cm depth were 3.28 and 7.32 kg C m{sup −2}, respectively. • SOC stocks were 34 and 16

Hot regions of labile and stable soil organic carbon in Germany - Spatial variability and driving factors

Science.gov (United States)

Vos, Cora; Jaconi, Angélica; Jacobs, Anna; Don, Axel

2018-06-01

Atmospheric carbon dioxide levels can be mitigated by sequestering carbon in the soil. Sequestration can be facilitated by agricultural management, but its influence is not the same on all soil carbon pools, as labile pools with a high turnover may be accumulated much faster but are also more vulnerable to losses. The aims of this study were to (1) assess how soil organic carbon (SOC) is distributed among SOC fractions on a national scale in Germany, (2) identify factors influencing this distribution and (3) identify regions with high vulnerability to SOC losses. The SOC content and proportion of two different SOC fractions were estimated for more than 2500 mineral topsoils (soil texture, bulk soil C / N ratio, total SOC content and pH. For some regions, the drivers were linked to the land-use history of the sites. Arable topsoils in central and southern Germany were found to contain the highest proportions and contents of stable SOC fractions, and therefore have the lowest vulnerability to SOC losses. North-western Germany contains an area of sandy soils with unusually high SOC contents and high proportions of light SOC fractions, which are commonly regarded as representing a labile carbon pool. This is true for the former peat soils in this area, which have already lost and are at high risk of losing high proportions of their SOC stocks. Those black sands can, however, also contain high amounts of stable SOC due to former heathland vegetation and need to be treated and discussed separately from non-black sand agricultural soils. Overall, it was estimated that, in large areas all over Germany, over 30 % of SOC is stored in easily mineralisable forms. Thus, SOC-conserving management of arable soils in these regions is of great importance.

Spatial variability of soil carbon across Mexico and the United States

Science.gov (United States)

Vargas, R.; Guevara, M.; Cruz Gaistardo, C.; Paz, F.; de Jong, B.; Etchevers, J.

2015-12-01

Soil organic carbon (SOC) is directly linked to soil quality, food security, and land use/global environmental change. We use publicly available information on SOC and couple it with digital elevation models and derived terrain attributes using a machine learning approach. We found a strong spatial dependency of SOC across the United States, but less spatial dependency of SOC across Mexico. Using High Performance Computing (HPC) we derived a 1 km resolution map of SOC across Mexico and the United States. We tested different machine learning methods (e.g., kernel based, tree based and/or Geo-statistics approaches) for computational efficiency and statistical accuracy. Using random forest combined with geo-statistics we were able to explain >70% of SOC variance for Mexico and >40% in the case of the United States via cross validation. These results compare with other published estimates of SOC at 1km resolution that only explain <30% of SOC variance across the world. Topographic attributes derived from digital elevation models are freely available globally at fine spatial resolution (<100 m), and this information allowed us to make predictions of SOC at fine scales. We further tested this approach using SOC information from the International Soil Carbon Network to predict SOC in other regions of the world. We conclude that this approach (using public information and open source platforms for data analysis) could be implemented to predict detailed explicit information of SOC across different spatial scales.

A molecular investigation of soil organic carbon composition across a subalpine catchment

Science.gov (United States)

Hsu, Hsiao-Tieh; Lawrence, Corey R.; Winnick, Matthew J.; Bargar, John R.; Maher, Katharine

2018-01-01

The dynamics of soil organic carbon (SOC) storage and turnover are a critical component of the global carbon cycle. Mechanistic models seeking to represent these complex dynamics require detailed SOC compositions, which are currently difficult to characterize quantitatively. Here, we address this challenge by using a novel approach that combines Fourier transform infrared spectroscopy (FT-IR) and bulk carbon X-ray absorption spectroscopy (XAS) to determine the abundance of SOC functional groups, using elemental analysis (EA) to constrain the total amount of SOC. We used this SOC functional group abundance (SOC-fga) method to compare variability in SOC compositions as a function of depth across a subalpine watershed (East River, Colorado, USA) and found a large degree of variability in SOC functional group abundances between sites at different elevations. Soils at a lower elevation are predominantly composed of polysaccharides, while soils at a higher elevation have more substantial portions of carbonyl, phenolic, or aromatic carbon. We discuss the potential drivers of differences in SOC composition between these sites, including vegetation inputs, internal processing and losses, and elevation-driven environmental factors. Although numerical models would facilitate the understanding and evaluation of the observed SOC distributions, quantitative and meaningful measurements of SOC molecular compositions are required to guide such models. Comparison among commonly used characterization techniques on shared reference materials is a critical next step for advancing our understanding of the complex processes controlling SOC compositions.

Erratum: Erratum to: Realistic interpretation of quantum mechanics and encounter-delayed-choice experiment

Science.gov (United States)

Long, GuiLu; Qin, Wei; Yang, Zhe; Li, Jun-Lin

2018-05-01

In our article [1] we made a mistake in citing ref. [32], which is the same as ref. [28]. We now replace ref. [32] with the correct reference "L. Hao, D. Liu, and G. L. Long, Sci. China Phys. Mech. Astron. 53, 1765 (2010)" [2].

Spin polarization of tunneling current in barriers with spin-orbit coupling

International Nuclear Information System (INIS)

Fujita, T; Jalil, M B A; Tan, S G

2008-01-01

We present a general method for evaluating the maximum transmitted spin polarization and optimal spin axis for an arbitrary spin-orbit coupling (SOC) barrier system, in which the spins lie in the azimuthal plane and finite spin polarization is achieved by wavevector filtering of electrons. Besides momentum filtering, another prerequisite for finite spin polarization is asymmetric occupation or transmission probabilities of the eigenstates of the SOC Hamiltonian. This is achieved most efficiently by resonant tunneling through multiple SOC barriers. We apply our analysis to common SOC mechanisms in semiconductors: pure bulk Dresselhaus SOC, heterostructures with mixed Dresselhaus and Rashba SOC and strain-induced SOC. In particular, we find that the interplay between Dresselhaus and Rashba SOC effects can yield several advantageous features for spin filter and spin injector functions, such as increased robustness to wavevector spread of electrons

Spin polarization of tunneling current in barriers with spin-orbit coupling.

Science.gov (United States)

Fujita, T; Jalil, M B A; Tan, S G

2008-03-19

We present a general method for evaluating the maximum transmitted spin polarization and optimal spin axis for an arbitrary spin-orbit coupling (SOC) barrier system, in which the spins lie in the azimuthal plane and finite spin polarization is achieved by wavevector filtering of electrons. Besides momentum filtering, another prerequisite for finite spin polarization is asymmetric occupation or transmission probabilities of the eigenstates of the SOC Hamiltonian. This is achieved most efficiently by resonant tunneling through multiple SOC barriers. We apply our analysis to common SOC mechanisms in semiconductors: pure bulk Dresselhaus SOC, heterostructures with mixed Dresselhaus and Rashba SOC and strain-induced SOC. In particular, we find that the interplay between Dresselhaus and Rashba SOC effects can yield several advantageous features for spin filter and spin injector functions, such as increased robustness to wavevector spread of electrons.

State of charge monitoring of vanadium redox flow batteries using half cell potentials and electrolyte density

Science.gov (United States)

Ressel, Simon; Bill, Florian; Holtz, Lucas; Janshen, Niklas; Chica, Antonio; Flower, Thomas; Weidlich, Claudia; Struckmann, Thorsten

2018-02-01

The operation of vanadium redox flow batteries requires reliable in situ state of charge (SOC) monitoring. In this study, two SOC estimation approaches for the negative half cell are investigated. First, in situ open circuit potential measurements are combined with Coulomb counting in a one-step calibration of SOC and Nernst potential which doesn't need additional reference SOCs. In-sample and out-of-sample SOCs are estimated and analyzed, estimation errors ≤ 0.04 are obtained. In the second approach, temperature corrected in situ electrolyte density measurements are used for the first time in vanadium redox flow batteries for SOC estimation. In-sample and out-of-sample SOC estimation errors ≤ 0.04 demonstrate the feasibility of this approach. Both methods allow recalibration during battery operation. The actual capacity obtained from SOC calibration can be used in a state of health model.

High-resolution digital mapping of soil organic carbon in permafrost terrain using machine learning: a case study in a sub-Arctic peatland environment

Science.gov (United States)

Siewert, Matthias B.

2018-03-01

Soil organic carbon (SOC) stored in northern peatlands and permafrost-affected soils are key components in the global carbon cycle. This article quantifies SOC stocks in a sub-Arctic mountainous peatland environment in the discontinuous permafrost zone in Abisko, northern Sweden. Four machine-learning techniques are evaluated for SOC quantification: multiple linear regression, artificial neural networks, support vector machine and random forest. The random forest model performed best and was used to predict SOC for several depth increments at a spatial resolution of 1 m (1×1 m). A high-resolution (1 m) land cover classification generated for this study is the most relevant predictive variable. The landscape mean SOC storage (0-150 cm) is estimated to be 8.3 ± 8.0 kg C m-2 and the SOC stored in the top meter (0-100 cm) to be 7.7 ± 6.2 kg C m-2. The predictive modeling highlights the relative importance of wetland areas and in particular peat plateaus for the landscape's SOC storage. The total SOC was also predicted at reduced spatial resolutions of 2, 10, 30, 100, 250 and 1000 m and shows a significant drop in land cover class detail and a tendency to underestimate the SOC at resolutions > 30 m. This is associated with the occurrence of many small-scale wetlands forming local hot-spots of SOC storage that are omitted at coarse resolutions. Sharp transitions in SOC storage associated with land cover and permafrost distribution are the most challenging methodological aspect. However, in this study, at local, regional and circum-Arctic scales, the main factor limiting robust SOC mapping efforts is the scarcity of soil pedon data from across the entire environmental space. For the Abisko region, past SOC and permafrost dynamics indicate that most of the SOC is barely 2000 years old and very dynamic. Future research needs to investigate the geomorphic response of permafrost degradation and the fate of SOC across all landscape compartments in post-permafrost landscapes.

The cross-sectional associations between sense of coherence and diabetic microvascular complications, glycaemic control, and patients' conceptions of type 1 diabetes

Directory of Open Access Journals (Sweden)

Saraheimo Markku

2010-11-01

Full Text Available Abstract Background Sense of coherence (SOC has been associated with various self-care behaviours in the general population. As the management of type 1 diabetes heavily relies on self-management, the SOC concept could also prove important in this population. This paper is a report of a study conducted among patients with type 1 diabetes to assess the associations between SOC and glycaemic control, microvascular complications, and patients' conceptions of their disease. Methods Altogether 1,264 adult patients (45% men, age range 18-82 years with type 1 diabetes participated in this cross-sectional study. SOC was evaluated using a 13-item SOC questionnaire. Standardized assays were used to determine HbA1c. Nephropathy status was based on albumin excretion rate and retinal laser-treatment was used as an indication of severe retinopathy. Patients' subjective conceptions of diabetes were studied using a questionnaire. Results Higher SOC scores, reflecting stronger SOC, were associated with lower HbA1c values. Strong SOC was independently associated with reaching the HbA1c level 1c, weak SOC was associated with the presence of nephropathy among men, but not women. No associations were observed between SOC and severe retinopathy. Four dimensions describing patients' conceptions of HbA1c, complications, diabetes control and hypoglycaemia were formed from the diabetes questionnaire. Weak SOC was independently associated with worse subjective conceptions in the dimensions of HbA1c and hypoglycaemia. Furthermore among men, an association between weak SOC and the complications factor was observed. Conclusion Interventions to improve patients' SOC, if available, could improve patients' metabolic control and therefore also reduce the incidence of diabetic complications.

Sensitivity of soil carbon fractions and their specific stabilization mechanisms to extreme soil warming in a subarctic grassland.

Science.gov (United States)

Poeplau, Christopher; Kätterer, Thomas; Leblans, Niki I W; Sigurdsson, Bjarni D

2017-03-01

Terrestrial carbon cycle feedbacks to global warming are major uncertainties in climate models. For in-depth understanding of changes in soil organic carbon (SOC) after soil warming, long-term responses of SOC stabilization mechanisms such as aggregation, organo-mineral interactions and chemical recalcitrance need to be addressed. This study investigated the effect of 6 years of geothermal soil warming on different SOC fractions in an unmanaged grassland in Iceland. Along an extreme warming gradient of +0 to ~+40 °C, we isolated five fractions of SOC that varied conceptually in turnover rate from active to passive in the following order: particulate organic matter (POM), dissolved organic carbon (DOC), SOC in sand and stable aggregates (SA), SOC in silt and clay (SC-rSOC) and resistant SOC (rSOC). Soil warming of 0.6 °C increased bulk SOC by 22 ± 43% (0-10 cm soil layer) and 27 ± 54% (20-30 cm), while further warming led to exponential SOC depletion of up to 79 ± 14% (0-10 cm) and 74 ± 8% (20-30) in the most warmed plots (~+40 °C). Only the SA fraction was more sensitive than the bulk soil, with 93 ± 6% (0-10 cm) and 86 ± 13% (20-30 cm) SOC losses and the highest relative enrichment in 13 C as an indicator for the degree of decomposition (+1.6 ± 1.5‰ in 0-10 cm and +1.3 ± 0.8‰ in 20-30 cm). The SA fraction mass also declined along the warming gradient, while the SC fraction mass increased. This was explained by deactivation of aggregate-binding mechanisms. There was no difference between the responses of SC-rSOC (slow-cycling) and rSOC (passive) to warming, and 13 C enrichment in rSOC was equal to that in bulk soil. We concluded that the sensitivity of SOC to warming was not a function of age or chemical recalcitrance, but triggered by changes in biophysical stabilization mechanisms, such as aggregation. © 2016 John Wiley & Sons Ltd.

Distribution of Soil Organic Carbon and the Influencing Factors in An Oasis Farmland Area

Directory of Open Access Journals (Sweden)

WANG Ze

2014-08-01

Full Text Available The soil organic carbon(SOC of a typical oasis farmland in middle part of Manasi county of Xinjiang was used as the research ob原 ject. Using remote sensing and lab analysis techniques, influences of soil texture, terrain, land uses, and crop types on SOC content of farmland were studied. Results showed that the SOC distribution in farmland of Manasi was mainly determined by comprehensive natural environmental factors. The SOC content decreased along with the increasing soil depth. For soil textures, the SOC content from high to low was clay loam>powder loam>silty loam. Slope direction had significantly positive correlations with SOC contents at 0～30 cm and 30～60 cm, while altitude and SOC content at 60～100 cm were significantly positive correlation. The SOC content of orchard was the highest, and the uncultivated land was the lowest under different land-use patterns. For different crop planting systems, the order of SOC content was corn field >wine grapes field>cotton field, and the difference was significant.

Investigating the error sources of the online state of charge estimation methods for lithium-ion batteries in electric vehicles

Science.gov (United States)

Zheng, Yuejiu; Ouyang, Minggao; Han, Xuebing; Lu, Languang; Li, Jianqiu

2018-02-01

Sate of charge (SOC) estimation is generally acknowledged as one of the most important functions in battery management system for lithium-ion batteries in new energy vehicles. Though every effort is made for various online SOC estimation methods to reliably increase the estimation accuracy as much as possible within the limited on-chip resources, little literature discusses the error sources for those SOC estimation methods. This paper firstly reviews the commonly studied SOC estimation methods from a conventional classification. A novel perspective focusing on the error analysis of the SOC estimation methods is proposed. SOC estimation methods are analyzed from the views of the measured values, models, algorithms and state parameters. Subsequently, the error flow charts are proposed to analyze the error sources from the signal measurement to the models and algorithms for the widely used online SOC estimation methods in new energy vehicles. Finally, with the consideration of the working conditions, choosing more reliable and applicable SOC estimation methods is discussed, and the future development of the promising online SOC estimation methods is suggested.

Agricultural management explains historic changes in regional soil carbon stocks

Science.gov (United States)

van Wesemael, Bas; Paustian, Keith; Meersmans, Jeroen; Goidts, Esther; Barancikova, Gabriela; Easter, Mark

2010-01-01

Agriculture is considered to be among the economic sectors having the greatest greenhouse gas mitigation potential, largely via soil organic carbon (SOC) sequestration. However, it remains a challenge to accurately quantify SOC stock changes at regional to national scales. SOC stock changes resulting from SOC inventory systems are only available for a few countries and the trends vary widely between studies. Process-based models can provide insight in the drivers of SOC changes, but accurate input data are currently not available at these spatial scales. Here we use measurements from a soil inventory dating from the 1960s and resampled in 2006 covering the major soil types and agricultural regions in Belgium together with region-specific land use and management data and a process-based model. The largest decreases in SOC stocks occurred in poorly drained grassland soils (clays and floodplain soils), consistent with drainage improvements since 1960. Large increases in SOC in well drained grassland soils appear to be a legacy effect of widespread conversion of cropland to grassland before 1960. SOC in cropland increased only in sandy lowland soils, driven by increasing manure additions. Modeled land use and management impacts accounted for more than 70% of the variation in observed SOC changes, and no bias could be demonstrated. There was no significant effect of climate trends since 1960 on observed SOC changes. SOC monitoring networks are being established in many countries. Our results demonstrate that detailed and long-term land management data are crucial to explain the observed SOC changes for such networks. PMID:20679194

Field #3 of the Palomar-Groningen Survey; 1, Variable stars at the edge of the Sagittarius dwarf galaxy

NARCIS (Netherlands)

Schultheis, M.

1996-01-01

Submitted to: Astron. Astrophys. Abstract: A catalogue is presented with variable (RR Lyrae, semiregular and Mira) stars located inside field #3 of the Palomar-Groningen Survey, at the outer edge of the Sagittarius dwarf galaxy. One of the semiregular variables is a carbon star, comparable with

LOFAR - low frequency array

NARCIS (Netherlands)

Bentum, Marinus Jan; Gunst, André

Nog een paar maanden en dan wordt de grootste radiotelescoop ter wereld officieel geopend: LOFAR, de ‘Low Frequency Arraÿ'.LOFAR is een nieuwe radiotelescoop die in Nederland gebouwd wordt door ASTRON, de Stichting Astronomisch Onderzoek in Nederland. Met LOFAR heeft Nederland er straks een uniek

The LOFAR Pulsar Data Pipeline

NARCIS (Netherlands)

Alexov, A.; Hessels, J.; Mol, J.D.; Stappers, B.; van Leeuwen, J.

2010-01-01

The LOw Frequency ARray (LOFAR) for radio astronomy is being built in the Netherlands by ASTRON, with extensions throughout Europe. LOFAR operates at radio frequencies below 250 MHz. The project is an interferometric array of radio antennas grouped into stations that are distributed over an area of

Suppressor of Overexpression of CO 1 Negatively Regulates Dark-Induced Leaf Degreening and Senescence by Directly Repressing Pheophytinase and Other Senescence-Associated Genes in Arabidopsis.

Science.gov (United States)

Chen, Junyi; Zhu, Xiaoyu; Ren, Jun; Qiu, Kai; Li, Zhongpeng; Xie, Zuokun; Gao, Jiong; Zhou, Xin; Kuai, Benke

2017-03-01

Although the biochemical pathway of chlorophyll (Chl) degradation has been largely elucidated, how Chl is rapidly yet coordinately degraded during leaf senescence remains elusive. Pheophytinase (PPH) is the enzyme for catalyzing the removal of the phytol group from pheophytin a , and PPH expression is significantly induced during leaf senescence. To elucidate the transcriptional regulation of PPH , we used a yeast ( Saccharomyces cerevisiae ) one-hybrid system to screen for its trans-regulators. SUPPRESSOR OF OVEREXPRESSION OF CO 1 (SOC1), a key flowering pathway integrator, was initially identified as one of the putative trans-regulators of PPH After dark treatment, leaves of an SOC1 knockdown mutant ( soc1-6 ) showed an accelerated yellowing phenotype, whereas those of SOC1 -overexpressing lines exhibited a partial stay-green phenotype. SOC1 and PPH expression showed a negative correlation during leaf senescence. Substantially, SOC1 protein could bind specifically to the CArG box of the PPH promoter in vitro and in vivo, and overexpression of SOC1 significantly inhibited the transcriptional activity of the PPH promoter in Arabidopsis ( Arabidopsis thaliana ) protoplasts. Importantly, soc1-6 pph-1 (a PPH knockout mutant) double mutant displayed a stay-green phenotype similar to that of pph-1 during dark treatment. These results demonstrated that SOC1 inhibits Chl degradation via negatively regulating PPH expression. In addition, measurement of the Chl content and the maximum photochemical efficiency of photosystem II of soc1-6 and SOC1-OE leaves after dark treatment suggested that SOC1 also negatively regulates the general senescence process. Seven SENESCENCE-ASSOCIATED GENES ( SAGs ) were thereafter identified as its potential target genes, and NONYELLOWING1 and SAG113 were experimentally confirmed. Together, we reveal that SOC1 represses dark-induced leaf Chl degradation and senescence in general in Arabidopsis. © 2017 American Society of Plant Biologists. All

A Combined State of Charge Estimation Method for Lithium-Ion Batteries Used in a Wide Ambient Temperature Range

Directory of Open Access Journals (Sweden)

Fei Feng

2014-05-01

Full Text Available Ambient temperature is a significant factor that influences the characteristics of lithium-ion batteries, which can produce adverse effects on state of charge (SOC estimation. In this paper, an integrated SOC algorithm that combines an advanced ampere-hour counting (Adv Ah method and multistate open-circuit voltage (multi OCV method, denoted as “Adv Ah + multi OCV”, is proposed. Ah counting is a simple and general method for estimating SOC. However, the available capacity and coulombic efficiency in this method are influenced by the operating states of batteries, such as temperature and current, thereby causing SOC estimation errors. To address this problem, an enhanced Ah counting method that can alter the available capacity and coulombic efficiency according to temperature is proposed during the SOC calculation. Moreover, the battery SOCs between different temperatures can be mutually converted in accordance with the capacity loss. To compensate for the accumulating errors in Ah counting caused by the low precision of current sensors and lack of accurate initial SOC, the OCV method is used for calibration and as a complement. Given the variation of available capacities at different temperatures, rated/non-rated OCV–SOCs are established to estimate the initial SOCs in accordance with the Ah counting SOCs. Two dynamic tests, namely, constant- and alternated-temperature tests, are employed to verify the combined method at different temperatures. The results indicate that our method can provide effective and accurate SOC estimation at different ambient temperatures.

Storage, patterns, and control of soil organic carbon and nitrogen in the northeastern margin of the Qinghai–Tibetan Plateau

International Nuclear Information System (INIS)

Liu Wenjie; Chen Shengyun; Qin Xiang; Zhou Zhaoye; Sun Weijun; Ren Jiawen; Qin Dahe; Baumann, Frank; Scholten, Thomas; Zhang Tongzuo

2012-01-01

This study tested the hypothesis that soil organic carbon (SOC) and total nitrogen (TN) spatial distributions show clear relationships with soil properties and vegetation composition as well as climatic conditions. Further, this study aimed to find the corresponding controlling parameters of SOC and TN storage in high-altitude ecosystems. The study was based on soil, vegetation and climate data from 42 soil pits taken from 14 plots. The plots were investigated during the summers of 2009 and 2010 at the northeastern margin of the Qinghai–Tibetan Plateau. Relationships of SOC density with soil moisture, soil texture, biomass and climatic variables were analyzed. Further, storage and vertical patterns of SOC and TN of seven representative vegetation types were estimated. The results show that significant relationships of SOC density with belowground biomass (BGB) and soil moisture (SM) can be observed. BGB and SM may be the dominant factors influencing SOC density in the topsoil of the study area. The average densities of SOC and TN at a depth of 1 m were about 7.72 kg C m −2 and 0.93 kg N m −2 . Both SOC and TN densities were concentrated in the topsoil (0–20 cm) and fell exponentially as soil depth increased. Additionally, the four typical vegetation types located in the northwest of the study area were selected to examine the relationship between SOC and environmental factors (temperature and precipitation). The results indicate that SOC density has a negative relationship with temperature and a positive relationship with precipitation diminishing with soil depth. It was concluded that SOC was concentrated in the topsoil, and that SOC density correlates well with BGB. SOC was predominantly influenced by SM, and to a much lower extent by temperature and precipitation. This study provided a new insight in understanding the control of SOC and TN density in the northeastern margin of the Qinghai–Tibetan Plateau. (letter)

Spatial variability of soil carbon stock in the Urucu river basin, Central Amazon-Brazil.

Science.gov (United States)

Ceddia, Marcos Bacis; Villela, André Luis Oliveira; Pinheiro, Érika Flávia Machado; Wendroth, Ole

2015-09-01

The Amazon Forest plays a major role in C sequestration and release. However, few regional estimates of soil organic carbon (SOC) stock in this ecoregion exist. One of the barriers to improve SOC estimates is the lack of recent soil data at high spatial resolution, which hampers the application of new methods for mapping SOC stock. The aims of this work were: (i) to quantify SOC stock under undisturbed vegetation for the 0-30 and the 0-100 cm under Amazon Forest; (ii) to correlate the SOC stock with soil mapping units and relief attributes and (iii) to evaluate three geostatistical techniques to generate maps of SOC stock (ordinary, isotopic and heterotopic cokriging). The study site is located in the Central region of Amazon State, Brazil. The soil survey covered the study site that has an area of 80 km(2) and resulted in a 1:10,000 soil map. It consisted of 315 field observations (96 complete soil profiles and 219 boreholes). SOC stock was calculated by summing C stocks by horizon, determined as a product of BD, SOC and the horizon thickness. For each one of the 315 soil observations, relief attributes were derived from a topographic map to understand SOC dynamics. The SOC stocks across 30 and 100 cm soil depth were 3.28 and 7.32 kg C m(-2), respectively, which is, 34 and 16%, lower than other studies. The SOC stock is higher in soils developed in relief forms exhibiting well-drained soils, which are covered by Upland Dense Tropical Rainforest. Only SOC stock in the upper 100 cm exhibited spatial dependence allowing the generation of spatial variability maps based on spatial (co)-regionalization. The CTI was inversely correlated with SOC stock and was the only auxiliary variable feasible to be used in cokriging interpolation. The heterotopic cokriging presented the best performance for mapping SOC stock. Copyright © 2015 Elsevier B.V. All rights reserved.

Environmental Impact Analysis Process. Deployment Area Selection and Land Withdrawal/Acquisition DEIS. Chapter V. Appendices.

Science.gov (United States)

1980-12-01

Cold blooded, backboned, animals which have adapted to live in water and on land. Animal Unit Month (AUM) The amount of forage necessary for the...Nevada. Techn. Rep. Serv. H-W. Hydrol. and Water Resources. Publ. No. 17. DRI, IJniv. Nevada, Reno. Beale, Dl. M., and A. D. Smith, 1970. Forage Use...Impact of Feral Cats and Dogs on Populations of the West Indian Rock Iguana , Cyclura carinata. Biol. Conserv. 14:63-73. Jense, G. K., and J. S. Burruss

Soil Organic Carbon Responses to Forest Expansion on Mountain Grasslands

DEFF Research Database (Denmark)

Guidi, Claudia

. Changes in labile soil C were assessed by carbohydrate and thermal analyses of soil samples and fractions. Forest expansion on mountain grasslands caused a decrease in SOC stocks within the mineral soil. The SOC accumulation within the organic layers following forest establishment could not fully...... and thermally labile to resistant components decreased from grassland to forest successional stages, and corresponded to decreased SOC protection within stable aggregates. This PhD thesis showed that mineral SOC stocks and physically protected SOC fractions decreased following forest expansion on mountain......Grassland abandonment followed by progressive forest expansion is the dominant land-use change in the European Alps. Contrasting trends in soil organic carbon (SOC) stocks have been reported for mountainous regions following forest expansion on grasslands. Moreover, its effects on SOC properties...

Using fourier-transform mid-infrared spectroscopy to distinguish soil organic matter composition dynamics in aggregate fractions of two agroecosystems

Science.gov (United States)

The relationship between soil organic carbon (SOC) content and quality of SOC as impacted by land management is not well understood and may influence long-term storage of SOC. To better understand the potential for SOC storage in specific aggregate pools (i.e. physically protected intra-aggregate C)...

High-resolution digital mapping of soil organic carbon in permafrost terrain using machine learning: a case study in a sub-Arctic peatland environment

Directory of Open Access Journals (Sweden)

M. B. Siewert

2018-03-01

Full Text Available Soil organic carbon (SOC stored in northern peatlands and permafrost-affected soils are key components in the global carbon cycle. This article quantifies SOC stocks in a sub-Arctic mountainous peatland environment in the discontinuous permafrost zone in Abisko, northern Sweden. Four machine-learning techniques are evaluated for SOC quantification: multiple linear regression, artificial neural networks, support vector machine and random forest. The random forest model performed best and was used to predict SOC for several depth increments at a spatial resolution of 1 m (1×1 m. A high-resolution (1 m land cover classification generated for this study is the most relevant predictive variable. The landscape mean SOC storage (0–150 cm is estimated to be 8.3 ± 8.0 kg C m−2 and the SOC stored in the top meter (0–100 cm to be 7.7 ± 6.2 kg C m−2. The predictive modeling highlights the relative importance of wetland areas and in particular peat plateaus for the landscape's SOC storage. The total SOC was also predicted at reduced spatial resolutions of 2, 10, 30, 100, 250 and 1000 m and shows a significant drop in land cover class detail and a tendency to underestimate the SOC at resolutions  >  30 m. This is associated with the occurrence of many small-scale wetlands forming local hot-spots of SOC storage that are omitted at coarse resolutions. Sharp transitions in SOC storage associated with land cover and permafrost distribution are the most challenging methodological aspect. However, in this study, at local, regional and circum-Arctic scales, the main factor limiting robust SOC mapping efforts is the scarcity of soil pedon data from across the entire environmental space. For the Abisko region, past SOC and permafrost dynamics indicate that most of the SOC is barely 2000 years old and very dynamic. Future research needs to investigate the geomorphic response of permafrost degradation and the fate of

PODAAC-SMP20-2SOCS

Data.gov (United States)

National Aeronautics and Space Administration — The version 2.0 SMAP-SSS, level 2C product contains the first release of the validated sea surface salinity orbital/swath data from the NASA Soil Moisture Active...

Synovial Osteochondromatosis at the Carpometacarpal Joint of the Thumb

Directory of Open Access Journals (Sweden)

Satoru Yonekura

2017-01-01

Full Text Available Synovial osteochondromatosis (SOC is a benign tumor characterized by synovial connective tissue metaplasia. SOC commonly affects major joints including the knee followed by the hip, elbow, and wrist. SOC cases in the hand are not reported as often as SOC of major joints. Particularly SOC of the carpometacarpal joint of the thumb is rare. We report on a 57-year-old female with primary SOC of the carpometacarpal joint of her left thumb. Surgical excision was performed and the patient had no symptoms with full range of motion of her left thumb. At 3 years of follow-up, there was no recurrence.

A ring galaxy at z = 1 lensed by the cluster Abell 370

NARCIS (Netherlands)

Soucail, G.; Kneib, J. P.; Bézecourt, J.; Metcalfe, L.; Altieri, B.; Borgne, J. F. le

1999-01-01

Published in: Astron. Astrophys. 343 (1999) L70 citations recorded in [Science Citation Index] Abstract: We present a study of a very peculiar object found in the field of the cluster-lens Abell 370. This object displays, in HST imaging, a spectacular morphology comparable to nearby ring-galaxies.

Evaluation of Cardiovascular Risk Scores Applied to NASA's Astronant Corps

Science.gov (United States)

Jain, I.; Charvat, J. M.; VanBaalen, M.; Lee, L.; Wear, M. L.

2014-01-01

In an effort to improve cardiovascular disease (CVD) risk prediction, this analysis evaluates and compares the applicability of multiple CVD risk scores to the NASA Astronaut Corps which is extremely healthy at selection.

IAA : Información y actualidad astronómica (29)

OpenAIRE

Toro, José Carlos del; López de Lacalle, Silbia; Claret dos Santos, Antonio; García, Emilio José; Alberdi, Antxón; Garrido, Rafael; Gorosabel, Javier; Márquez, Isabel; Jaramillo, José Luis; Santos Sanz, Pablo; Osorio, Mayra

2009-01-01

Sumario : Sunrise, una aventura polar.-- Nuestra tormentosa estrella.-- ¿Son válidos los modelos de atmósferas estelares?.-- ¿Viajaremos más rápido que la luz?.-- HISTORIAS DE ASTRONOMÍA. Últimas tardes con Hipatia.-- DECONSTRUCCIÓN Y otros ENSAYOS. Edwin Hubble.-- EL “MOBY DICK” DE... Antxon Alberdi (IAA-CSIC).-- ACTUALIDAD.-- Betelgeuse en ebullición.-- ¿Qué supone el hallazgo de glicina en el cometa 81P/Wild?.-- ¿Existe el cinturón de Gould?.-- Cosmología d...

[Using 137Cs and 210Pb(ex) to trace the impact of soil erosion on soil organic carbon at a slope farmland in the black soil region].

Science.gov (United States)

Fang, Hai-Yan; Sheng, Mei-Ling; Sun, Li-Ying; Cai, Qiang-Guo

2013-07-01

Soil cores were collected from a 28.5 hm2 slope farmland in the black soil region of Northeast China. Based on the sampled data of 137Cs, 210Pb(ex) and SOC, the potentials of applying 137Cs and 210Pb(ex) for assessing SOC redistribution were evaluated, aimed to approach the impact of soil erosion on soil organic carbon (SOC) in black soil region. At both planar and vertical directions, the 137Cs, 210Pb(ex) and SOC in the farmland had similar distribution patterns. Although there were large planar variations in the 137Cs and 210Pb(ex) areal activities and the SOC stock as affected by soil erosion and deposition, the 137Cs, 210Pb(ex) and SOC had similar changing trends over the landscape. Two depth distribution profiles were also used to study the relations of 137Cs and 210Pb(ex) with SOC. At eroded site, the radioactivities of 137Cs and 210Pb(ex) and the SOC mass fraction did not show large variations in 0-25 cm soil layer, but decreased sharply below 25 cm. For the deposition sample, the radioactivities of 137Cs and 210Pb(ex) in 0-100 cm soil increased firstly and then decreased. The SOC mass fraction also had similar depth distribution pattern in this soil layer. The 137Cs and 210Pb(ex) presented positive linear correlations with the SOC, indicating that 137Cs, 210Pb(ex) and SOC moved with the same physical mechanism in the farmland, and fallout 137Cs and 210Pb(ex) could be used to study spatio-temporal distribution characteristics of SOC in the black soil region under the condition of soil erosion.

Organo-mineral interactions promote greater soil organic carbon stability under aspen in semi-arid montane forests in Utah

Science.gov (United States)

Van Miegroet, H.; Roman Dobarco, M.

2014-12-01

Forest species influence soil organic carbon (SOC) storage through litter input, which in interaction with soil microclimate, texture and mineralogy, lead to different SOC stabilization and storage patterns. We sampled mineral soil (0-15 cm) across the ecotone between aspen (Populus tremuloides) and mixed conifers stands (Abies lasiocarpa and Pseudotsuga menziesii) in semi-arid montane forests from Utah, to investigate the influence of vegetation vs. site characteristics on SOC stabilization, storage and chemistry. SOC was divided into light fraction (LF), mineral-associated SOC in the silt and clay fraction (MoM), and a dense subfraction > 53 μm (SMoM) using wet sieving and electrostatic attraction. SOC decomposability and solubility was derived from long term laboratory incubations and hot water extractions (HWE). Fourier transform infrared spectroscopy (FTIR) was used to study differences in chemical functional groups in LF and MoM. Vegetation cover did not affect SOC storage (47.0 ± 16.5 Mg C ha-1), SOC decomposability (cumulative CO2-C release of 93.2 ± 65.4 g C g-1 C), or SOC solubility (9.8 ± 7.2 mg C g-1 C), but MoM content increased with presence of aspen [pure aspen (31.2 ± 15.1 Mg C ha-1) > mixed (25.7 ± 8.8 Mg C ha-1) > conifer (22.8 ± 9.0 Mg C ha-1)]. Organo-mineral complexes reduced biological availability of SOC, indicated by the negative correlation between silt+clay (%) and decomposable SOC per gram of C (r = -0.48, p = 0.001) or soluble SOC (r = -0.59, p plant or microbial origin. FTIR spectra clustered by sites with similar parent material rather than by vegetation cover. This suggests that initial differences in litter chemistry between aspen and conifers converged into similar MoM chemistry within sites.

State of charge estimation of lithium-ion batteries using the open-circuit voltage at various ambient temperatures

International Nuclear Information System (INIS)

Xing, Yinjiao; He, Wei; Pecht, Michael; Tsui, Kwok Leung

2014-01-01

Highlights: • An offline OCV–SOC–temperature table was established to infer battery SOC. • A temperature-based model was developed to estimate SOC at different temperatures. • The algorithm for SOC estimation was verified by dynamic current load. • The robustness of the approach was validated by different initial SOC values. - Abstract: Ambient temperature is a significant factor that influences the accuracy of battery SOC estimation, which is critical for remaining driving range prediction of electric vehicles (EVs) and optimal charge/discharge control of batteries. A widely used method to estimate SOC is based on an online inference of open-circuit voltage (OCV). However, the fact that the OCV–SOC is dependent on ambient temperature can result in errors in battery SOC estimation. To address this problem, this paper presents an SOC estimation approach based on a temperature-based model incorporated with an OCV–SOC–temperature table. The unscented Kalman filtering (UKF) was applied to tune the model parameters at each sampling step to cope with various uncertainties arising from the operation environment, cell-to-cell variation, and modeling inaccuracy. Two dynamic tests, the dynamic stress test (DST) and the federal urban driving schedule (FUDS), were used to test batteries at different temperatures. Then, DST was used to identify the model parameters while FUDS was used to validate the performance of the SOC estimation. The estimation was made covering the major working range from 25% to 85% SOC. The results indicated that our method can provide accurate SOC estimation with smaller root mean squared errors than the method that does not take into account ambient temperature. Thus, our approach is effective and accurate when battery operates at different ambient temperatures. Since the developed method takes into account the temperature factor as well as the complexity of the model, it could be effectively applied in battery management systems for

Rapid Estimation Method for State of Charge of Lithium-Ion Battery Based on Fractional Continual Variable Order Model

Directory of Open Access Journals (Sweden)

Xin Lu

2018-03-01

Full Text Available In recent years, the fractional order model has been employed to state of charge (SOC estimation. The non integer differentiation order being expressed as a function of recursive factors defining the fractality of charge distribution on porous electrodes. The battery SOC affects the fractal dimension of charge distribution, therefore the order of the fractional order model varies with the SOC at the same condition. This paper proposes a new method to estimate the SOC. A fractional continuous variable order model is used to characterize the fractal morphology of charge distribution. The order identification results showed that there is a stable monotonic relationship between the fractional order and the SOC after the battery inner electrochemical reaction reaches balanced. This feature makes the proposed model particularly suitable for SOC estimation when the battery is in the resting state. Moreover, a fast iterative method based on the proposed model is introduced for SOC estimation. The experimental results showed that the proposed iterative method can quickly estimate the SOC by several iterations while maintaining high estimation accuracy.

[Distribution characteristics of soil organic carbon under different forest restoration modes on opencast coal mine dump].

Science.gov (United States)

Wen, Yue-rong; Dang, Ting-hui; Tang, Jun; Li, Jun-chao

2016-01-01

The content and storage of soil organic carbon (SOC) were compared in six wood restoration modes and adjacent abandoned land on opencast coal mine dump, and the mechanisms behind the differences and their influencing factors were analyzed. Results showed that the contents of SOC in six wood lands were significantly higher (23.8%-53.2%) than that of abandoned land (1.92 g · kg⁻¹) at 0-10 cm soil depth, the index were significantly higher (5.8%-70.4%) at 10-20 cm soil depth than the abandoned land (1.39 g · kg⁻¹), and then the difference of the contents of SOC in the deep soil (20-100 cm) were not significant. The contents of SOC decreased with increase of soil depth, but the decreasing magnitude of the topsoil (0-20 cm) was higher than that of the deep soil (20-100 cm). Compared with the deep soil, the topsoil significant higer storage of SOC in different woods, the SOC storage decreased with the soil depth. Along the 0-100 cm soil layer, the storage of SOC in six wood lands higher (18.1%-42.4%) than that of the abandoned land (17.52 t · hm⁻²). The SOC storage of Amorpha fruticosa land (24.95 t · hm⁻²) was obviously higher than that in the other wood lands. The SOC storage in the shrub lands was 12.4% higher than that of the arbor woods. There were significantly positive correlations among forest litter, fine root biomass, soil water content and SOC on the dump. Consequently, different plantation restorations significantly improved the SOC level on the dump in 0-100 cm soil, especially the topsoil. But there was still a big gap about SOC level between the wood restoration lands and the original landform. To improve the SOC on opencast coal mine dump, A. fruticosa could be selected as the main wood vegetation.