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Sample records for pubertal timing sexual

  1. Pubertal Timing and Adolescent Sexual Behavior in Girls

    Science.gov (United States)

    Moore, Sarah R.; Harden, K. Paige; Mendle, Jane

    2014-01-01

    Girls who experience earlier pubertal timing relative to peers also exhibit earlier timing of sexual intercourse and more unstable sexual relationships. Although pubertal development initiates feelings of physical desire, the transition into romantic and sexual relationships involves complex biological and social processes contributing both to…

  2. Pubertal timing and adolescent sexual behavior in girls.

    Science.gov (United States)

    Moore, Sarah R; Harden, K Paige; Mendle, Jane

    2014-06-01

    Girls who experience earlier pubertal timing relative to peers also exhibit earlier timing of sexual intercourse and more unstable sexual relationships. Although pubertal development initiates feelings of physical desire, the transition into romantic and sexual relationships involves complex biological and social processes contributing both to physical maturation and to individual interpretations of pubertal experiences. Using a sample of female sibling pairs (n = 923 pairs) from the National Longitudinal Study of Adolescent Health, the present study investigated associations among menarche and perceived pubertal timing, age of first sexual intercourse (AFI), and adolescent dating and sexual behavior using a behavioral genetic approach. Genetic factors influencing age at menarche and perceived pubertal timing predicted AFI through shared genetic pathways, whereas genetic factors related only to perceived pubertal timing predicted engagement in dating, romantic sex, and nonromantic sex in the previous 18 months. These results suggest that a girl's interpretation of her pubertal timing beyond objective timing is important to consider for the timing and the contexts of romantic and reproductive behavior. PsycINFO Database Record (c) 2014 APA, all rights reserved.

  3. Pubertal Timing and Early Sexual Intercourse in the Offspring of Teenage Mothers

    Science.gov (United States)

    De Genna, Natacha M.; Larkby, Cynthia; Cornelius, Marie D.

    2011-01-01

    Early puberty is associated with stressful family environments, early sexual intercourse, and teenage pregnancy. We examined pubertal timing and sexual debut among the 14-year-old offspring of teenage mothers. Mothers (71% Black, 29% White) were recruited as pregnant teenagers (12-18 years old). Data were collected during pregnancy and when…

  4. Pubertal Timing and Early Sexual Intercourse in the Offspring of Teenage Mothers

    Science.gov (United States)

    De Genna, Natacha M.; Larkby, Cynthia; Cornelius, Marie D.

    2011-01-01

    Early puberty is associated with stressful family environments, early sexual intercourse, and teenage pregnancy. We examined pubertal timing and sexual debut among the 14-year-old offspring of teenage mothers. Mothers (71% Black, 29% White) were recruited as pregnant teenagers (12-18 years old). Data were collected during pregnancy and when…

  5. Pubertal timing and sexual risk behaviors among rural African American male youth: testing a model based on life history theory.

    Science.gov (United States)

    Kogan, Steven M; Cho, Junhan; Simons, Leslie Gordon; Allen, Kimberly A; Beach, Steven R H; Simons, Ronald L; Gibbons, Frederick X

    2015-04-01

    Life History Theory (LHT), a branch of evolutionary biology, describes how organisms maximize their reproductive success in response to environmental conditions. This theory suggests that challenging environmental conditions will lead to early pubertal maturation, which in turn predicts heightened risky sexual behavior. Although largely confirmed among female adolescents, results with male youth are inconsistent. We tested a set of predictions based on LHT with a sample of 375 African American male youth assessed three times from age 11 to age 16. Harsh, unpredictable community environments and harsh, inconsistent, or unregulated parenting at age 11 were hypothesized to predict pubertal maturation at age 13; pubertal maturation was hypothesized to forecast risky sexual behavior, including early onset of intercourse, substance use during sexual activity, and lifetime numbers of sexual partners. Results were consistent with our hypotheses. Among African American male youth, community environments were a modest but significant predictor of pubertal timing. Among those youth with high negative emotionality, both parenting and community factors predicted pubertal timing. Pubertal timing at age 13 forecast risky sexual behavior at age 16. Results of analyses conducted to determine whether environmental effects on sexual risk behavior were mediated by pubertal timing were not significant. This suggests that, although evolutionary mechanisms may affect pubertal development via contextual influences for sensitive youth, the factors that predict sexual risk behavior depend less on pubertal maturation than LHT suggests.

  6. Understanding the Link Between Pubertal Timing in Girls and the Development of Depressive Symptoms: The Role of Sexual Harassment.

    Science.gov (United States)

    Skoog, Therése; Bayram Özdemir, Sevgi; Stattin, Håkan

    2016-02-01

    The link between sexual maturation, or pubertal timing, in girls and adolescent depressive symptoms is well-documented, but the underlying processes remain unclear. We examined whether sexual harassment, which has previously been linked to both pubertal timing and depressive symptoms, mediates this link, using a two-wave longitudinal study including 454 girls in 7th (M age  = 13.42, SD = .53) and 8th grade (M age  = 14.42, SD = .55). Pubertal timing was linked to depressive symptoms in both age groups, and predicted an increase in depressive symptoms among the 7th graders. Sexual harassment significantly mediated the link between pubertal timing and depressive symptoms among the 7th, but not the 8th grade girls. Together, our findings suggest that one way to prevent depressive symptoms among early-maturing girls could be to address sexual harassment in preventive intervention in early adolescence.

  7. The influence of early sexual debut and pubertal timing on psychological distress among Taiwanese adolescents.

    Science.gov (United States)

    Chiao, Chi; Ksobiech, Kate

    2015-01-01

    This study examined the relative influence of early sexual debut (ESD) and pubertal timing on psychological distress from adolescence to young adulthood in Taiwan, a non-Western society with a distinct cultural and family context. Data were from a cohort sample of 15-year-olds (N = 2595) first interviewed in 2000, with four follow-ups during a 7-year period. Psychological distress was assessed by a reduced form of the Symptom Checklist-90 Revised. ESD was defined by first intercourse at age 15 or younger. Multivariate analyses via growth curve modeling found a greater increase in psychological distress over time in adolescents with ESD (β = .28, p influence of both ESD and pubertal timing on distress trajectories, independent of parental and family characteristics.

  8. Transitions in Body and Behavior : A Meta-Analytic Study on the Relationship Between Pubertal Development and Adolescent Sexual Behavior

    OpenAIRE

    Baams, Laura; Dubas, Judith Semon; Overbeek, Geertjan; Aken, Marcel A. G.

    2015-01-01

    The present meta-analysis studies the relations of pubertal timing and status with sexual behavior and sexual risk behavior among youth aged 10.5-22.4 years. We included biological sex, age, and ethnicity as potential moderators. Four databases were searched for studies (published between 1980 and 2012) on the relation between pubertal timing or status and sexual behavior. The outcomes were (1) sexual intercourse; (2) combined sexual behavior; and (3) risky sexual behavior. Earlier pubertal t...

  9. The Stability of Perceived Pubertal Timing across Adolescence

    Science.gov (United States)

    Cance, Jessica Duncan; Ennett, Susan T.; Morgan-Lopez, Antonio A.; Foshee, Vangie A.

    2011-01-01

    It is unknown whether perceived pubertal timing changes as puberty progresses or whether it is an important component of adolescent identity formation that is fixed early in pubertal development. The purpose of this study is to examine the stability of perceived pubertal timing among a school-based sample of rural adolescents aged 11 to 17 (N=6,425; 50% female; 53% White). Two measures of pubertal timing were used, stage-normative, based on the Pubertal Development Scale, a self-report scale of secondary sexual characteristics, and peer-normative, a one-item measure of perceived pubertal timing. Two longitudinal methods were used: one-way random effects ANOVA models and latent class analysis. When calculating intraclass correlation coefficients using the one-way random effects ANOVA models, which is based on the average reliability from one time point to the next, both measures had similar, but poor, stability. In contrast, latent class analysis, which looks at the longitudinal response pattern of each individual and treats deviation from that pattern as measurement error, showed three stable and distinct response patterns for both measures: always early, always on-time, and always late. Study results suggest instability in perceived pubertal timing from one age to the next, but this instability is likely due to measurement error. Thus, it may be necessary to take into account the longitudinal pattern of perceived pubertal timing across adolescence rather than measuring perceived pubertal timing at one point in time. PMID:21983873

  10. Transitions in body and behavior: a meta-analytic study on the relationship between pubertal development and adolescent sexual behavior.

    Science.gov (United States)

    Baams, Laura; Dubas, Judith Semon; Overbeek, Geertjan; van Aken, Marcel A G

    2015-06-01

    The present meta-analysis studies the relations of pubertal timing and status with sexual behavior and sexual risk behavior among youth aged 10.5-22.4 years. We included biological sex, age, and ethnicity as potential moderators. Four databases were searched for studies (published between 1980 and 2012) on the relation between pubertal timing or status and sexual behavior. The outcomes were (1) sexual intercourse; (2) combined sexual behavior; and (3) risky sexual behavior. Earlier pubertal timing or more advanced pubertal status was related to earlier and more sexual behavior, and earlier pubertal timing was related to more risky sexual behavior. Further, the links between (1) pubertal status and combined sexual behavior and (2) pubertal timing and sexual intercourse status, combined sexual behavior, and risky sexual behavior were stronger for girls than boys. Most links between pubertal status, timing, and sexual behavior and sexual risk behavior were stronger for younger adolescents. Moderation by ethnicity did not yield consistent results. There was significant variation in results among studies that was not fully explained by differences in biological sex, age, and ethnicity. Future research is needed to identify moderators that explain the variation in effects and to design sexual health interventions for young adolescents. Copyright © 2015 Society for Adolescent Health and Medicine. Published by Elsevier Inc. All rights reserved.

  11. Modeling pubertal timing and tempo and examining links to behavior problems.

    Science.gov (United States)

    Beltz, Adriene M; Corley, Robin P; Bricker, Josh B; Wadsworth, Sally J; Berenbaum, Sheri A

    2014-12-01

    Research on the role of puberty in adolescent psychological development requires attention to the meaning and measurement of pubertal development. Particular questions concern the utility of self-report, the need for complex models to describe pubertal development, the psychological significance of pubertal timing vs. tempo, and sex differences in the nature and psychological significance of pubertal development. We used longitudinal self-report data to model linear and logistic trajectories of pubertal development, and used timing and tempo estimates from these models, and from traditional approaches (age at menarche and time from onset of breast development to menarche), to predict psychological outcomes of internalizing and externalizing behavior problems, and early sexual activity. Participants (738 girls, 781 boys) reported annually from ages 9 through 15 on their pubertal development, and they and their parents reported on their behavior in mid-to-late adolescence and early adulthood. Self-reports of pubertal development provided meaningful data for both boys and girls, producing good trajectories, and estimates of individuals' pubertal timing and tempo. A logistic model best fit the group data. Pubertal timing was estimated to be earlier in the logistic compared to linear model, but linear, logistic, and traditional estimates of pubertal timing correlated highly with each other and similarly with psychological outcomes. Pubertal tempo was not consistently estimated, and associations of tempo with timing and with behavior were model dependent. Advances in modeling facilitate the study of some questions about pubertal development, but assumptions of the models affect their utility in psychological studies. PsycINFO Database Record (c) 2014 APA, all rights reserved.

  12. Pubertal pair-housing facilitates adult sexual behavior in male rats.

    Science.gov (United States)

    Molenda-Figueira, Heather A; Bell, Margaret R; De Lorme, Kayla C; Sisk, Cheryl L

    2017-01-01

    This study examined the effects of pubertal testosterone (T) and social housing manipulations on male sexual behavior in adult rats. Prepubertal rats were castrated at 21 days of age (P21) and implanted with either blank or T-releasing pellets. At the onset of puberty, P28, half the rats in each treatment group were either single- or pair-housed with a male of the same hormone condition through P56, at which time pellets were removed and all rats were single-housed. In adulthood (P84), all rats received T replacement and were tested for sexual behavior. Rats pair-housed during adolescence showed more sexual behavior and greater improvement of sexual performance over repeated tests than single-housed rats, regardless of pubertal T status. Pubertal T, however, did facilitate the frequency of anogenital investigation. Thus, in male rats, social interactions during adolescence are more important than exposure to pubertal T in enhancing adult sexual behavior. © 2016 Wiley Periodicals, Inc.

  13. Pubertal Onset in Boys and Girls Is Influenced by Pubertal Timing of Both Parents

    DEFF Research Database (Denmark)

    Wohlfahrt-Veje, Christine; Mouritsen, Annette; Hagen, Casper P

    2016-01-01

    CONTEXT: Epidemiological evidence on maternal and paternal heritability of the wide normal variation within pubertal timing is sparse. OBJECTIVE: We aimed to estimate the impact of parental pubertal timing on the onset of puberty in boys and girls. DESIGN: Annual pubertal examinations of healthy...... children in a longitudinal cohort study. Information on parental timing of puberty (earlier, comparable to, or later compared to peers) and menarche age was retrieved from questionnaires. PARTICIPANTS: A total of 672 girls and 846 boys. MAIN OUTCOME MEASURES: Age at onset of pubic hair (PH2+), breasts (B2......+), and menarche in girls; and PH2+, genital stage (G2+), and testis >3 mL with orchidometer (Tvol3+) in boys. RESULTS: In boys, pubertal onset was significantly associated with pubertal timing of both parents. PH2+ and Tvol3+ were earlier: -11.8 months (95% confidence interval, -16.8, -6.8)/-8.9 (-12.8, -4...

  14. Transitions in Body and Behavior: A Meta-Analytic Study on the Relationship Between Pubertal Development and Adolescent Sexual Behavior

    NARCIS (Netherlands)

    Baams, L.; Dubas, J.S.; Overbeek, G.J.; van Aken, M.A.G.

    2015-01-01

    The present meta-analysis studies the relations of pubertal timing and status with sexual behavior and sexual risk behavior among youth aged 10.5-22.4 years. We included biological sex, age, and ethnicity as potential moderators. Four databases were searched for studies (published between 1980 and 2

  15. The organizational effects of pubertal testosterone on sexual proficiency in adult male Syrian hamsters.

    Science.gov (United States)

    De Lorme, Kayla C; Sisk, Cheryl L

    2016-10-15

    Social proficiency requires making appropriate behavioral adaptations as a result of social experience. For example, male rodents become sexually proficient with experience as demonstrated by a reduction in ectopic (misdirected) mounts, mount-to-intromission ratio, and latency to ejaculation. We previously found that over a series of timed tests with a receptive female, male hamsters deprived of testosterone specifically during puberty (NoT@P) have overall lower levels of sexual behavior and continue to display high levels of ectopic mounts, compared with males that experienced endogenous testosterone during puberty (T@P). These results suggested that pubertal testosterone programs sexual proficiency in adulthood, but because NoT@P males engaged in less sexual behavior than T@P males in these tests, the amount of sexual experience may have been insufficient to improve sexual proficiency. To more rigorously test the hypothesis that pubertal testosterone is necessary for social proficiency in adulthood, the present study compared the behavior of NoT@P and T@P males in a series of 4 trials with a 48-h interval between each trial. Sexual experience was equated by limiting each trial to 5 intromissions. Sexually-naïve males were either gonadectomized prepubertally (NoT@P) or in adulthood (T@P) and received subcutaneous testosterone capsules four weeks later. Two weeks after testosterone replacement, these groups and a group of adult gonad-intact controls began sexual behavior testing. We found that NoT@P males had more ectopic mounts/min across all four tests compared to gonad-intact and T@P males. Moreover, both gonad-intact and T@P males, but not NoT@P males, showed an increase in the number of mounts and intromissions/min between trials 1 and 3. Unexpectedly, both gonad-intact and T@P, but not NoT@P, males showed a decrease in sexual behaviors during trial 4. Thus, T@P males display multiple behavioral adaptations to sexual experience that are not observed in No

  16. Associations of Peripubertal Serum Dioxin and Polychlorinated Biphenyl Concentrations with Pubertal Timing among Russian Boys.

    Science.gov (United States)

    Burns, Jane S; Lee, Mary M; Williams, Paige L; Korrick, Susan A; Sergeyev, Oleg; Lam, Thuy; Revich, Boris; Hauser, Russ

    2016-11-01

    Dioxins, furans, and polychlorinated biphenyls (PCBs), dioxin-like and non-dioxin-like, have been linked to alterations in puberty. We examined the association of peripubertal serum levels of these compounds [and their toxic equivalents (TEQs)] with pubertal onset and maturity among Russian boys enrolled at ages 8-9 years and followed prospectively through ages 17-18 years. At enrollment, 473 boys had serum dioxin-like compounds and PCBs measured. At the baseline visit and annually until age 17-18 years, a physician performed pubertal staging [genitalia (G), pubarche (P), and testicular volume (TV)]. Three hundred fifteen subjects completed the follow-up visit at 17-18 years of age. Pubertal onset was defined as TV > 3 mL, G2, or P2. Sexual maturity was defined as TV ≥ 20 mL, G5, or P5. Multivariable interval-censored models were used to evaluate associations of lipid-standardized concentrations with pubertal timing. Medians (interquartile ranges) of the sum of dioxin-like compounds, TEQs, and non-dioxin-like PCBs were 362 pg/g lipid (279-495), 21.1 pg TEQ/g lipid (14.4-33.2), and 250 ng/g lipid (164-395), respectively. In adjusted models, the highest compared to lowest TEQ quartile was associated with later pubertal onset [TV = 11.6 months (95% CI: 3.8, 19.4); G2 = 10.1 months (95% CI: 1.4, 18.8)] and sexual maturity [TV = 11.6 months (95% CI: 5.7, 17.6); G5 = 9.7 months (95% CI: 3.1, 16.2)]. However, the highest compared to the lowest quartile of non-dioxin-like PCBs, when co-adjusted by TEQs, was associated with earlier pubertal onset [TV = -8.3 months (95% CI:-16.2, -0.3)] and sexual maturity [TV = -6.3 months (95% CI:-12.2, -0.3); G5 = -7.2 months (95% CI:-13.8, -0.6)]; the non-dioxin-like PCB associations were only significant when adjusted for TEQs. TEQs and PCBs were not significantly associated with pubic hair development. Our results suggest that TEQs may delay, while non-dioxin-like PCBs advance, the timing of male puberty. Citation: Burns JS, Lee MM

  17. Early Pubertal Timing and Girls' Problem Behavior: Integrating Two Hypotheses

    Science.gov (United States)

    Stattin, Hakan; Kerr, Margaret; Skoog, Therese

    2011-01-01

    Girls' early pubertal timing has been linked in many studies to behavioral problems such as delinquency and substance use. The theoretical explanations for these links have often involved the girls' peer relationships, but contexts have also been considered important in some explanations. By integrating two theoretical models, the…

  18. [Peculiarities of sexual behavior of female rats with hyperandrogenia in pubertal and postpubertal periods].

    Science.gov (United States)

    Nosenko, N D; Lymarieva, A A

    2013-01-01

    The parameters of female and male sexual behavior in 3- and 6- month old female rats which were exposed to an androgen excess (subcutaneous implantation of Silastic capsules containing 5 mg of crystalline testosterone) from the beginning of pubertal period (at the age of 35 days), or within postpubertal period (at the age of 4 months). Hyperandrogenia in pubertal period had no effect on female sexual behavior formation, but it led to appearance of male behavior components in 100% of animals. In female rats which were implanted with testosterone capsules in postpubertal period, sexual disturbances were more pronounced and were characterized by masculinization and defeminization, which was due to a higher degree of androgenic saturation. The data obtained suggest a leading role of hyperandrogenemia in the pathogenesis of sexual behavior disturbances in female rats in different periods of individual development.

  19. Association Between Urinary Phthalates and Pubertal Timing in Chinese Adolescents

    Directory of Open Access Journals (Sweden)

    Huijing Shi

    2015-09-01

    Full Text Available Background: Phthalates are synthetic chemicals and ubiquitous environmental contaminants, with hormonal activity that may alter the course of pubertal development in children. Objectives: To determine whether exposure to phthalate metabolites is associated with timing of pubertal development in a cross-sectional study of a school-based clustered sample of 503 children from a suburban district in Shanghai, China, who were 7–14 years of age at enrollment (2010 October to November. Methods: We analyzed six phthalate metabolites in urine samples by isotope-dilution liquid chromatography tandem mass spectrometry. The associations of exposures to phthalates with pubertal timing of testes, breast, and pubic hair development (represented as Tanner stages were evaluated using an ordered logistic regression model adjusted for chronological age, body fat proportion (BF%, and parental education. Results: In boys, urinary mono-n-butyl phthalate (MBP levels were negatively associated with testicular volume, and mono (2-ethyl-5-hydroxyhexyl phthalate (MEHHP and mono (2-ethyl-5-oxohexyl phthalate (MEOHP levels were negatively associated with pubic hair stages. The odds of being in an advanced stage were decreased by 43%–51%. In girls, mono (2-ethylhexyl phthalate (MEHP, MEHHP, and MEOHP levels, as well as the sum of these levels, were positively associated with breast stages, and the association was much stronger in girls with high BF%; the odds of being in an advanced stage were increase by 29% to 50%. Conclusions: Phthalate metabolites investigated in this study show significant associations with pubertal timing both in boys and in girls, especially among girls with high BF%.

  20. [Pubertal maturation, physical self-esteem and sexuality in a sample of French adolescents].

    Science.gov (United States)

    Potard, C; Courtois, R; Clarisse, R; Le Floc'h, N; Thomine, M; Réveillère, C

    2016-04-01

    The aim of this study was to explore the links between pubertal maturation, physical self-esteem and sexuality in adolescence, differentiating between boys and girls. The sample was comprised of 312 French secondary school children (seventh and ninth grades); 52.6 % (n=164) of whom were girls. Participants answered three self-evaluation questionnaires: the scale of sexuality (interests, emotions, relationships: IERS) in prime adolescence (12 to 15 years); (b) the self-administered rating scale for pubertal development and (c) the Physical Self-Description Questionnaire (PSDQ). Pubertal maturation was associated with higher scores on "Flirting with the aim of having sexual relations" and "Going out with someone", and a drop in overall and physical self-esteem, mainly in socially valued domains, namely "Body fat" for girls, and "Strength" and "Health" for boys. Overall physical self-esteem was associated with "Going out with someone" and "Flirting with the aim of having sexual relations" in boys. Physical changes at puberty induce two distinct trends in adolescents: sexual exploration and discovery (genitalized body), and self-depreciation (social body). Copyright © 2015 L’Encéphale, Paris. Published by Elsevier Masson SAS. All rights reserved.

  1. Current Changes in Pubertal Timing: Revised Vision in Relation with Environmental Factors Including Endocrine Disruptors.

    Science.gov (United States)

    Parent, Anne-Simone; Franssen, Delphine; Fudvoye, Julie; Pinson, Anneline; Bourguignon, Jean-Pierre

    2016-01-01

    The aim of this chapter is to revise some common views on changes in pubertal timing. This revision is based on recent epidemiological findings on the clinical indicators of pubertal timing and data on environmental factor effects and underlying mechanisms. A current advancement in timing of female puberty is usually emphasized. It appears, however, that timing is also changing in males. Moreover, the changes are towards earliness for initial pubertal stages and towards lateness for final stages in both sexes. Such observations indicate the complexity of environmental influences on pubertal timing. The mechanisms of changes in pubertal timing may involve both the central neuroendocrine control and peripheral effects at tissues targeted by gonadal steroids. While sufficient energy availability is a clue to the mechanism of pubertal development, changes in the control of both energy balance and reproduction may vary under the influence of common determinants such as endocrine-disrupting chemicals (EDCs). These effects can take place right before puberty as well as much earlier, during fetal and neonatal life. Finally, environmental factors can interact with genetic factors in determining changes in pubertal timing. Therefore, the variance in pubertal timing is no longer to be considered under absolutely separate control by environmental and genetic determinants. Some recommendations are provided for evaluation of EDC impact in the management of pubertal disorders and for possible reduction of EDC exposure along the precautionary principle.

  2. Sexual differentiation of human behavior: effects of prenatal and pubertal organizational hormones.

    Science.gov (United States)

    Berenbaum, Sheri A; Beltz, Adriene M

    2011-04-01

    A key question concerns the extent to which sexual differentiation of human behavior is influenced by sex hormones present during sensitive periods of development (organizational effects), as occurs in other mammalian species. The most important sensitive period has been considered to be prenatal, but there is increasing attention to puberty as another organizational period, with the possibility of decreasing sensitivity to sex hormones across the pubertal transition. In this paper, we review evidence that sex hormones present during the prenatal and pubertal periods produce permanent changes to behavior. There is good evidence that exposure to high levels of androgens during prenatal development results in masculinization of activity and occupational interests, sexual orientation, and some spatial abilities; prenatal androgens have a smaller effect on gender identity, and there is insufficient information about androgen effects on sex-linked behavior problems. There is little good evidence regarding long-lasting behavioral effects of pubertal hormones, but there is some suggestion that they influence gender identity and perhaps some sex-linked forms of psychopathology, and there are many opportunities to study this issue.

  3. Pubertal Timing and Depressive Symptoms in Early Adolescents: The Roles of Romantic Competence and Romantic Experiences

    Science.gov (United States)

    Stroud, Catherine B.; Davila, Joanne

    2008-01-01

    In spite of the large literature supporting the link between early pubertal timing and depression in adolescent girls, there are some exceptions. This suggests that there may be factors that interact with pubertal timing, increasing risk for depression in some girls, but not others. This study examined two such factors, romantic competence and…

  4. Ethnicity, Perceived Pubertal Timing, Externalizing Behaviors, and Depressive Symptoms among Black Adolescent Girls

    Science.gov (United States)

    Carter, Rona; Caldwell, Cleopatra Howard; Matusko, Niki; Antonucci, Toni; Jackson, James S.

    2011-01-01

    An accumulation of research evidence suggests that early pubertal timing plays a significant role in girls' behavioral and emotional problems. If early pubertal timing is a problematic event, then early developing Black girls should manifest evidence of this crisis because they tend to be the earliest to develop compared to other girls from…

  5. Peer and Individual Risk Factors in Adolescence Explaining the Relationship Between Girls' Pubertal Timing and Teenage Childbearing.

    Science.gov (United States)

    Hendrick, C Emily; Cance, Jessica Duncan; Maslowsky, Julie

    2016-05-01

    Girls with early pubertal timing are at elevated risk for teenage childbearing; however, the modifiable mechanisms driving this relationship are not well understood. The objective of the current study was to determine whether substance use, perceived peer substance use, and older first sexual partners mediate the relationships among girls' pubertal timing, sexual debut, and teenage childbearing. Data are from Waves 1-15 of the female cohort of the National Longitudinal Surveys of Youth 1997 (NLSY97), a nationwide, ongoing cohort study of U.S. men and women born between 1980 and 1984. The analytic sample (n = 2066) was 12-14 years old in 1997 and ethnically diverse (51 % white, 27 % black, 22 % Latina). Using structural equation modeling, we found substance use in early adolescence and perceived peer substance use each partially mediated the relationships among girls' pubertal timing, sexual debut, and teenage childbearing. Our findings suggest early substance use behavior as one modifiable mechanism to be targeted by interventions aimed at preventing teenage childbearing among early developing girls.

  6. Sex 'n' drugs 'n' rock 'n' roll: the meaning and social consequences of pubertal timing.

    Science.gov (United States)

    Waylen, Andrea; Wolke, Dieter

    2004-11-01

    This is a brief review of the normal changes in adolescent behaviour and the interplay between biology and social factors that occur at and around puberty, in an attempt to explain when this transition may become problematic The onset of puberty is a biological marker for an individual's transition from a non-reproductive to a reproductive state. Adolescence is a normal developmental transition associated with clearly visible physical changes, reorganization and pruning of neuronal circuits in the brain and the occurrence of new behaviours and interests. It is a time when new life tasks (orientation towards peers of the other sex, romantic and sexual involvement and mastering an educational career) need to be mastered. Parent-child conflict increases and becomes more intense as the adolescent struggles for more independence while still requiring support. These normal changes can become problematic if biological and social expectations diverge e.g. entering puberty very early or very late. While early pubertal onset in boys is likely to have beneficial effects, in girls precocious pubertal timing may have a negative impact on body-image, affect (or emotional well-being) and sex-role expectations. Other individual biological predispositions and genetic endowment may interact with social factors (e.g. peers, parenting style, neighbourhood) making adolescence either an adaptive or a challenging transition. There is a lack of sufficiently large longitudinal studies that have been able to study this interaction between genetics, biology and social environment on adolescent development. The Avon Longitudinal Study of Parents and Children (ALSPAC) cohort provides a unique opportunity to investigate the impact of pubertal timing on social behaviour. Planned assessments and concepts are outlined.

  7. Recent changes in pubertal timing in healthy Danish boys

    DEFF Research Database (Denmark)

    Sørensen, K; Aksglæde, Lise; Petersen, Jørgen Holm;

    2010-01-01

    In the 1990s, the American population-based study NHANES III renewed the focus on possible secular trends in male puberty. However, no conclusions could be made on pubertal onset due to the lack of compatible data....

  8. Off-Time Pubertal Timing Predicts Physiological Reactivity to Postpuberty Interpersonal Stress

    Science.gov (United States)

    Smith, Anne Emilie; Powers, Sally I.

    2009-01-01

    We investigated associations between retrospectively assessed timing of pubertal development, interpersonal interactions, and hypothalamic-pituitary-adrenal axis reactivity to an interpersonal stress task in 110 young adult women. Participants provided salivary cortisol samples at points prior and subsequent to a video-taped conflict discussion…

  9. Pubertal Stress and Nutrition and their Association with Sexual Orientation and Height in the Add Health Data.

    Science.gov (United States)

    Skorska, Malvina N; Bogaert, Anthony F

    2017-01-01

    A number of studies have indicated that gay men tend to be shorter, on average, than heterosexual men. Less evidence exists that lesbian women are taller, on average, than heterosexual women. The most popular explanation of the association between sexual orientation and height involves prenatal factors, such that, for example, gay men may have been exposed to lower than typical androgens during fetal development, which impacts their height and sexual orientation as adults. An alternative explanation involves stress, given that stress has been associated with sexual minority identification and with lower height. Another alternative explanation involves nutrition, although its relationship is less clear with sexual minority identification. Using the Add Health data, which is a large, nationally representative and longitudinal sample of American adolescents (n = 14,786), we tested a mediation model, such that sexual orientation → pubertal stress/nutrition → height. Within men, we found that gay men (n = 126) were shorter, on average, than heterosexual men (n = 6412). None of the 24 pubertal stress-related and 15 pubertal nutrition-related variables assessed in the Add Health data mediated the relationship between sexual orientation and height in men. Within women, lesbians (n = 75) did not differ significantly in stature compared to heterosexual women (n = 6267). Thus, prenatal mechanisms (e.g., hormones, maternal immune response) are likely better candidates for explaining the height difference between gay men and heterosexual men.

  10. Childhood body size and pubertal timing in relation to adult mammographic density phenotype.

    Science.gov (United States)

    Schoemaker, Minouk J; Jones, Michael E; Allen, Steven; Hoare, Jean; Ashworth, Alan; Dowsett, Mitch; Swerdlow, Anthony J

    2017-02-07

    An earlier age at onset of breast development and longer time between pubertal stages has been implicated in breast cancer risk. It is not clear whether associations of breast cancer risk with puberty or predictors of onset of puberty, such as weight and height, are mediated via mammographic density, an important risk factor for breast cancer. We investigated whether childhood body size and pubertal timing and tempo, collected by questionnaire, are associated with percentage and absolute area mammographic density at ages 47-73 years in 1105 women recruited to a prospective study. After controlling for adult adiposity, weight at ages 7 and 11 years was strongly significantly inversely associated with percentage and absolute dense area (p trend density (p trend = 0.016). Later age at menarche and age at when regular periods were established was associated with increased density, but additional adjustment for childhood weight attenuated the association. A longer interval between thelarche and menarche, and between thelarche and regular periods, was associated with increased dense area, even after adjusting for childhood weight (p trend = 0.013 and 0.028, respectively), and was independent of age at pubertal onset. Greater prepubertal weight and earlier pubertal onset are associated with lower adult breast density, but age at pubertal onset does not appear to have an independent effect on adult density after controlling for childhood adiposity. A possible effect of pubertal tempo on density needs further investigation.

  11. Pituitary volume mediates the relationship between pubertal timing and depressive symptoms during adolescence.

    Science.gov (United States)

    Whittle, Sarah; Yücel, Murat; Lorenzetti, Valentina; Byrne, Michelle L; Simmons, Julian G; Wood, Stephen J; Pantelis, Christos; Allen, Nicholas B

    2012-07-01

    Early timing of puberty (i.e., advanced pubertal maturation relative to peers) has been linked to the onset of depressive symptoms during the early adolescent phase. However, the precise neurobiological mechanisms linking early pubertal timing to adolescent depressive symptoms are not clear. We investigated whether the volume of the pituitary gland, a key component of the hypothalamic-pituitary-gonadal (HPG) and hypothalamic-pituitary-adrenal (HPA) axes, mediated the relationship between pubertal timing and depressive symptoms in 155 adolescents (72 females) both cross-sectionally and longitudinally. At baseline (M age 12.7, SD 0.5 years), early pubertal timing predicted larger pituitary gland volume and higher depressive symptoms (especially for girls), but there was no mediation effect. Longitudinally, however, larger pituitary gland volume at baseline was found to mediate the relationship between early pubertal timing and increased depressive symptoms over time (M follow-up period=2.57 years, SD=0.26) for both boys and girls. Our findings suggest that neurobiological mechanisms are partly responsible for the link between early pubertal timing and depressive symptoms in adolescents. We speculate that an enlarged pituitary gland in adolescents with early pubertal timing might be associated with hyperactivation of the hormonal stress response, leading to increased susceptibility to environmental stressors, and subsequent development of depressive symptoms. Given the well-established relationship between increasing depressive symptoms in adolescence and later disorder, these findings have implications for targeted prevention and early intervention strategies for depressive disorders in adolescence. Copyright © 2011 Elsevier Ltd. All rights reserved.

  12. Dioxin and Polychlorinated Biphenyl Concentrations in Mother's Serum and the Timing of Pubertal Onset in Sons

    Science.gov (United States)

    Humblet, Olivier; Williams, Paige L.; Korrick, Susan A.; Sergeyev, Oleg; Emond, Claude; Birnbaum, Linda S.; Burns, Jane S.; Altshul, Larisa; Patterson, Donald G.; Turner, Wayman E.; Lee, Mary M.; Revich, Boris; Hauser, Russ

    2013-01-01

    Background Animal studies have demonstrated that timing of pubertal onset can be altered by prenatal exposure to dioxins or polychlorinated biphenyls (PCBs), but studies of human populations have been quite limited. Methods We assessed the association between maternal serum concentrations of dioxins and PCBs and the sons’ age of pubertal onset in a prospective cohort of 489 mother–son pairs from Chapaevsk, Russia, a town contaminated with these chemicals during past industrial activity. The boys were recruited at ages 8 to 9 years, and 4 years of annual follow-up data were included in the analysis. Serum samples were collected at enrollment from both mothers and sons for measurement of dioxin and PCB concentrations using high-resolution mass spectrometry. The sons’ pubertal onset—defined as pubertal stage 2 or higher for genitalia (G) or pubic hair (P), or testicular volume >3 mL—was assessed annually by the same physician. Results In multivariate Cox models, elevated maternal serum PCBs were associated with earlier pubertal onset defined by stage G2 or higher (4th quartile hazard ratio = 1.7 [95% confidence interval = 1.1– 2.5]), but not for stage P2 or higher or for testicular volume >3 mL. Maternal serum concentrations of dioxin toxic equivalents were not consistently associated with the sons’ pubertal onset, although a dose-related delay in pubertal onset (only for G2 or higher) was seen among boys who breast-fed for 6 months or more. Conclusions Maternal PCB serum concentrations measured 8 or 9 years after sons’ births—which may reflect sons’ prenatal and early-life exposures—were associated with acceleration in some, but not all, measures of pubertal onset. PMID:21968773

  13. Genome-wide Association and Longitudinal Analyses Reveal Genetic Loci Linking Pubertal Height Growth, Pubertal Timing, and Childhood Adiposity

    DEFF Research Database (Denmark)

    Cousminer, Diana L; Berry, Diane J; Timpson, Nicholas J

    2013-01-01

    and adverse cardiometabolic health. The only gene so far associated with pubertal height growth, LIN28B, pleiotropically influences childhood growth, puberty, and cancer progression, pointing to shared underlying mechanisms.To discover genetic loci influencing pubertal height and growth and place them...

  14. Elite athletes and pubertal delay.

    Science.gov (United States)

    Kapczuk, Karina

    2017-10-01

    Intensive physical training and participation in competitive sports during childhood and early adolescence may affect athletes' pubertal development. On the other hand, pubertal timing, early or late, may impact on an athlete selection for a particular sport. Genetic predisposition, training load, nutritional status and psychological stress determine athletes' pubertal timing. Athletes that practice esthetic sports, especially gymnasts, are predisposed to a delay in pubertal development. The growing evidence indicates that energy deficiency, not a systemic training per se, plays a crucial role in the pathogenesis of functional hypothalamic hypogonadism in female athletes. Metabolic and psychologic stress activate hypothalamic-pituitary-adrenal axis and suppress hypothalamic-pituitary-ovarian axis. Female athletes who do not begin secondary sexual development by the age of 14 or menstruation by the age of 16 warrant a comprehensive evaluation and a targeted treatment. Somatic growth and sexual maturation of elite female athletes are largely sport-specific since each sport favors a particular somatotype and requires a specific training. Chronic negative energy balance resulting from a systemic physical training and inadequate energy intake may delay pubertal development in elite athletes. Youth athletes, especially those engaged in competitive sports that emphasize prepubertal or lean appearance, are at risk of developing relative energy deficiency in sport associated with disordered eating or eating disorders. Management strategies should address the complex conditions underlying functional hypothalamic hypogonadism.

  15. The Role of Pubertal Timing in What Adolescent Boys Do Online

    Science.gov (United States)

    Skoog, Therese; Stattin, Hakan; Kerr, Margaret

    2009-01-01

    The aim of this study was to investigate associations between pubertal timing and boys' Internet use, particularly their viewing of pornography. We used a sample comprising of 97 boys in grade 8 (M age, 14.22 years) from two schools in a medium-sized Swedish town. This age should be optimal for differentiating early, on-time, and later-maturing…

  16. Sexually dimorphic innate immunological responses of pre-pubertal Brahman cattle following an intravenous lipopolysaccharide challenge.

    Science.gov (United States)

    Carroll, Jeffery A; Burdick Sanchez, Nicole C; Hulbert, Lindsey E; Ballou, Michael A; Dailey, Jeffery W; Caldwell, Lisa C; Vann, Rhonda C; Welsh, Thomas H; Randel, Ronald D

    2015-08-15

    This study was designed to characterize potential sexually dimorphic immunological responses following a lipopolysaccharide (LPS) challenge in beef cattle. Six female (heifers) and five male (bulls) Brahman calves (average age=253 ± 19.9 and 288 ± 47.9 days; average body weight=194 ± 11 kg and 247 ± 19 kg for heifers and bulls, respectively) were challenged with LPS (0.25 μg LPS/kg body weight). Following administration of LPS, all cattle displayed increased sickness behavior beginning at 0.5h, with heifers on average displaying less sickness behavior than bulls. A febrile response was observed in all animals following LPS administration, with a maximum response observed from 4 to 5.5h. The average rectal temperature response was greater in heifers than bulls. In all cattle there were elevated serum concentrations of cortisol from 0.5 to 8h, TNF-α from 1 to 2.5h, IL-6 from 2 to 8h, and IFN-γ from 2.5 to 7h after LPS challenge. Additionally, serum concentrations of TNF-α were greater in heifers than bulls from 1.5 to 2h after the LPS challenge. Concentrations of IFN-γ were also greater on average in bulls than heifers. Leukopenia occurred from 1 to 8h, with a decreased neutrophil to lymphocyte ratio for the first 5h among all calves. These data demonstrate the existence of a sexually dimorphic acute-phase response in pre-pubertal Brahman calves. Specifically, heifers may have a more robust acute response to LPS challenge, even though bulls display more signs of sickness. Published by Elsevier B.V.

  17. 遗传因素对青春期启动时间的调控%Genetics of pubertal timing

    Institute of Scientific and Technical Information of China (English)

    马晓宇

    2010-01-01

    青春期是性成熟并获得生殖能力的重要发育阶段.遗传因素是对个体青春期启动时间影响最大的因素.近来分子遗传学的分析逐渐阐明了一些青春发育时间异常疾病的遗传学基础,例如特发性低促性腺激素性性功能减退症和Kallmann综合征.一般人群青春启动时间变异的遗传学基础成为目前研究的热点,然而迄今为止却没有一个基因位点被证实与性发育时间有关.该文主要阐述与青春期启动时间异常有关的基因学研究进展,并讨论与正常青春期启动时间有关的基因.%Puberty is an important developmental stage that leads to sexual maturation and reproductive capability. Genetic factors play a significant role in regulating the variation of pubertal timing. Recent genetic analysis are increasingly elucidating the genetic basis of disorders of pubertal timing such as hypogonadotropic hypogonadism and Kallmann syndrome. Ongoing studies are also investigating the genetic control of puberty in the general population, although no genetic loci have been reproducibly associated with pubertal timing thus far. This review summarizes an update of the genes implicated in disorders of puberty,discusses genes that may be involved in the timing of normal puberty.

  18. Early adolescent boys’ exposure to Internet pornography: relationships to pubertal timing, sensation seeking, and academic performance

    NARCIS (Netherlands)

    I. Beyens; L. Vandenbosch; S. Eggermont

    2014-01-01

    Research has demonstrated that adolescents regularly use Internet pornography. This two-wave panel study aimed to test an integrative model in early adolescent boys (Mage = 14.10; N = 325) that (a) explains their exposure to Internet pornography by looking at relationships with pubertal timing and s

  19. Pubertal Timing and Mexican-Origin Girls' Internalizing and Externalizing Symptoms: The Influence of Harsh Parenting

    Science.gov (United States)

    Deardorff, Julianna; Cham, Heining; Gonzales, Nancy A.; White, Rebecca M. B.; Tein, Jenn-Yun; Wong, Jessie J.; Roosa, Mark W.

    2013-01-01

    Early-maturing girls are at risk for internalizing and externalizing problems. Research concerning pubertal timing and mental health among Mexican Americans or the influence of parenting behaviors on these relations has been scarce. This study addressed these gaps. This was a prospective examination of 362 Mexican-origin girls and their mothers in…

  20. Early Adolescent Boys' Exposure to Internet Pornography: Relationships to Pubertal Timing, Sensation Seeking, and Academic Performance

    Science.gov (United States)

    Beyens, Ine; Vandenbosch, Laura; Eggermont, Steven

    2015-01-01

    Research has demonstrated that adolescents regularly use Internet pornography. This two-wave panel study aimed to test an integrative model in early adolescent boys (M[subscript age] = 14.10; N = 325) that (a) explains their exposure to Internet pornography by looking at relationships with pubertal timing and sensation seeking, and (b) explores…

  1. Early Pubertal Timing and the Union Formation Behaviors of Young Women

    Science.gov (United States)

    Cavanagh, Shannon E.

    2011-01-01

    This study examined whether the transition into adolescence, proxied by pubertal timing, shaped the transition into adulthood, proxied by union formation behaviors, among contemporary American women. In a sample drawn from Add Health (n = 7,523), early maturing girls reported an accelerated transition to marriage and cohabitation in young…

  2. Early adolescent boys’ exposure to Internet pornography: relationships to pubertal timing, sensation seeking, and academic performance

    NARCIS (Netherlands)

    Beyens, I.; Vandenbosch, L.; Eggermont, S.

    2015-01-01

    Research has demonstrated that adolescents regularly use Internet pornography. This two-wave panel study aimed to test an integrative model in early adolescent boys (Mage = 14.10; N = 325) that (a) explains their exposure to Internet pornography by looking at relationships with pubertal timing and s

  3. Early Adolescent Boys' Exposure to Internet Pornography: Relationships to Pubertal Timing, Sensation Seeking, and Academic Performance

    Science.gov (United States)

    Beyens, Ine; Vandenbosch, Laura; Eggermont, Steven

    2015-01-01

    Research has demonstrated that adolescents regularly use Internet pornography. This two-wave panel study aimed to test an integrative model in early adolescent boys (M[subscript age] = 14.10; N = 325) that (a) explains their exposure to Internet pornography by looking at relationships with pubertal timing and sensation seeking, and (b) explores…

  4. Subjective Age in Early Adolescence: Relationships with Chronological Age, Pubertal Timing, Desired Age, and Problem Behaviors

    Science.gov (United States)

    Hubley, Anita M.; Arim, Rubab G.

    2012-01-01

    Subjective age generally refers to the age that one feels. In a cross-sectional questionnaire study of 245 adolescents ages 10-14 years, we examined (a) whether, and when, a cross-over in subjective age occurs, (b) differences in subjective age among pubertal timing groups, (c) correlations between subjective age and each of desired age and five…

  5. Consequences of Early Life Programing by Genetic and Environmental Influences: A Synthesis Regarding Pubertal Timing.

    Science.gov (United States)

    Roth, Christian L; DiVall, Sara

    2016-01-01

    Sexual maturation is closely tied to growth and body weight gain, suggesting that regulative metabolic pathways are shared between somatic and pubertal development. The pre- and postnatal environment affects both growth and pubertal development, indicating that common pathways are affected by the environment. Intrauterine and early infantile developmental phases are characterized by high plasticity and thereby susceptibility to factors that affect metabolic function as well as related reproductive function throughout life. In children born small for gestational age, poor nutritional conditions during gestation can modify metabolic systems to adapt to expectations of chronic undernutrition. These children are potentially poorly equipped to cope with energy-dense diets and are possibly programmed to store as much energy as possible, causing rapid weight gain with the risk for adult disease and premature onset of puberty. Environmental factors can cause modifications to the genome, so-called epigenetic changes, to affect gene expression and subsequently modify phenotypic expression of genomic information. Epigenetic modifications, which occur in children born small for gestational age, are thought to underlie part of the metabolic programming that subsequently effects both somatic and pubertal development. © 2016 S. Karger AG, Basel.

  6. Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity

    NARCIS (Netherlands)

    Cousminer, Diana L.; Berry, Diane J.; Timpson, Nicholas J.; Ang, Wei; Thiering, Elisabeth; Byrne, Enda M.; Taal, H. Rob; Huikari, Ville; Bradfield, Jonathan P.; Kerkhof, Marjan; Groen-Blokhuis, Maria M.; Kreiner-Moller, Eskil; Marinelli, Marcella; Holst, Claus; Leinonen, Jaakko T.; Perry, John R. B.; Surakka, Ida; Pietilainen, Olli; Kettunen, Johannes; Anttila, Verneri; Kaakinen, Marika; Sovio, Ulla; Pouta, Anneli; Das, Shikta; Lagou, Vasiliki; Power, Chris; Prokopenko, Inga; Evans, David M.; Kemp, John P.; St Pourcain, Beate; Ring, Susan; Palotie, Aarno; Kajantie, Eero; Osmond, Clive; Lehtimaki, Terho; Viikari, Jorma S.; Kahonen, Mika; Warrington, Nicole M.; Lye, Stephen J.; Palmer, Lyle J.; Tiesler, Carla M. T.; Flexeder, Claudia; Montgomery, Grant W.; Medland, Sarah E.; Hofman, Albert; Hakonarson, Hakon; Guxens, Monica; Bartels, Meike; Salomaa, Veikko; Murabito, Joanne M.; Kaprio, Jaakko; Sorensen, Thorkild I. A.; Ballester, Ferran; Bisgaard, Hans; Boomsma, Dorret I.; Koppelman, Gerard H.; Grant, Struan F. A.; Jaddoe, Vincent W. V.; Martin, Nicholas G.; Heinrich, Joachim; Pennell, Craig E.; Raitakari, Olli T.; Eriksson, Johan G.; Smith, George Davey; Hypponen, Elina; Jarvelin, Marjo-Riitta; McCarthy, Mark I.; Ripatti, Samuli; Widen, Elisabeth

    2013-01-01

    The pubertal height growth spurt is a distinctive feature of childhood growth reflecting both the central onset of puberty and local growth factors. Although little is known about the underlying genetics, growth variability during puberty correlates with adult risks for hormone-dependent cancer and

  7. Sex differences in time to task failure during early pubertal development.

    Science.gov (United States)

    Rudroff, Thorsten; Holmes, Matthew R; Melanson, Edward L; Kelsey, Megan M

    2014-06-01

    We compared fatigability and activation of elbow flexor muscles in children at 3 pubertal stages during a sustained submaximal contraction. In 72 healthy children (39 boys) aged 11 ± 3 years (range, 8-14 years), differences in fatigability (time to task failure) and muscle activation were compared at 3 Tanner stages (T1-T3). Time to task failure and muscle activation were similar between boys and girls at prepubertal Tanner stage 1. Time to task failure was briefer for girls than boys at Tanner stages 2 and 3 and was predicted by the coactivation indices and percent body fat in girls. Muscle torque was the only predictor for the time to task failure in boys. Differences in fatigability and muscle coactivation were evident during the initial pubertal stages (T2 and T3), but not before the onset of puberty (T1). Copyright © 2013 Wiley Periodicals, Inc.

  8. Pubertal status, pre-meal drink composition, and later meal timing interact in determining children's appetite and food intake.

    Science.gov (United States)

    Patel, Barkha P; Hamilton, Jill K; Vien, Shirley; Thomas, Scott G; Anderson, G Harvey

    2016-09-01

    Puberty is a period of development that alters energy intake patterns. However, few studies have examined appetite and food intake (FI) regulation during development of puberty in children and adolescents. Therefore, the objective was to measure the effect of pubertal status on FI and subjective appetite after pre-meal glucose and whey protein drinks in 9- to 14-year-old boys and girls. In a within-subject, randomized, repeated-measures design, children (21 pre-early pubertal, 15 mid-late pubertal) received equally sweetened drinks containing Sucralose (control), glucose, or whey protein (0.75 g/kg body weight) in 250 mL of water 2 h after a standardized breakfast on 6 separate mornings. Ad libitum FI was measured either 30 or 60 min later and appetite was measured over time. In pre-early and mid-late pubertal boys and girls there was no effect of sex on total FI (kcal). Glucose and whey protein drinks reduced calorie intake similarly at 30 min. But at 60 min, whey protein reduced FI (p children, but not in mid-late pubertal children. However, sex was a factor (p = 0.041) when FI was expressed per kilogram body weight. Pubertal status did not affect FI/kilogram body weight in boys, but it was 32% lower in mid-late pubertal girls than at pre-early puberty (p = 0.010). Appetite was associated with FI in mid-late pubertal children only. In conclusion, pubertal development affects appetite and FI regulation in children.

  9. Pubertal timing and adult obesity and cardiometabolic risk in women and men: a systematic review and meta-analysis.

    Science.gov (United States)

    Prentice, P; Viner, R M

    2013-08-01

    Obesity has complex multifactorial aetiology. It has been suggested by many, but not all, reports that earlier pubertal maturation may increase adult obesity risk. We conducted a systemic review and meta-analysis in both women and men, and hypothesised that any association between pubertal timing and adult obesity is likely to be confounded by childhood adiposity. In addition, we investigated whether pubertal timing is related to other cardiometabolic risk and long-term cardiovascular morbidity/mortality. Literature search was undertaken using MEDLINE, EMBASE, Web of Knowledge and TRIP databases, with a hand search of references. Both authors independently reviewed and extracted pre-defined data from all selected papers. Meta-analyses were conducted using Review Manager (RevMan) 5.0.24. A total of 48 papers were identified. Out of 34 studies, 30 reported an inverse relationship between pubertal timing and adult body mass index (BMI), the main adiposity measure used. Meta-analysis of 10 cohorts showed association between early menarche (menarche metabolic syndrome (MetS) and abnormal glycaemia. Earlier pubertal timing is predictive of higher adult BMI and greater risk of obesity. This effect appears to be partially independent of childhood BMI. Earlier pubertal development appears to also be inversely correlated with risk of other cardiometabolic risk factors and cardiovascular mortality. Further work is needed to examine potential mechanisms and the level at which interventions may be targeted.

  10. Stimulation of gonadal development by sexual interaction of pubertal African catfish, Clarias gariepinus.

    Science.gov (United States)

    van Weerd, J H; Sukkel, M; Bongers, A B; van der Does, H M; Steynis, E; Richter, C J

    1991-02-01

    Stimulation and inhibition of gonadal development by intersexual contact was studied in pubertal African catfish, Clarias gariepinus. The effect of a possible interaction was studied by evaluation after a 98-day experimental period of gonadal development in combinations of intact and anosmic males and females. In addition, separate groups of males and females, respectively, were exposed to holding water from these combinations. A tentative model of stimulation of gonadal development by intersexual contact in pubertal fish was developed. Males stimulate ovarian development of females by both olfactory and tactile cues. In addition, males seem to enhance gonadal development of other males through olfactory stimulation via holding water. In contrast, females tended to inhibit male gonadal development, especially through tactile cues. It seems that although males are hampered by female tactile stimuli in their gonadal development and ability to stimulate male gonadal development, their ability to stimulate female gonadal development is not affected.

  11. Pubertal timing and health-related behaviours in adolescence - socio- economic outcomes in a follow-up study from Finland

    Directory of Open Access Journals (Sweden)

    Leena K Koivusilta

    2006-03-01

    Full Text Available

    Background. Pubertal timing is connected with health-related lifestyle in adulthood. We studied whether early or late pubertal timing is predictive of socio-economic outcomes in early adulthood and whether the associations are mediated by health behaviours.

    Methods. Survey data (1981, 1983, 1985, 1987 from samples of 14-year-old Finns (N=4246, response rate 85% were linked with respondents’ attained educational level, socio-economic and labour market position in 2001 (ages 28-34. Ages of menarche and first ejaculation indicated pubertal timing.

    Results. As compared to adolescents with average age pubertal timing, boys and girls maturing at an early age more often participated in health-compromising behaviours, while those maturing at a later age participated less frequently. Pubertal timing was not associated with attained educational level or socioeconomic position in girls and not with labour market position at the time of follow-up in either sex. In boys, independently of health behaviours, early or late onset of puberty predicted low educational level, while late onset predicted low socio-economic position.

    Conclusion. Timing of puberty has a stronger connection with socio-economic outcomes in boys than in girls. Deviance from the normative pace of physical development, especially late maturation, is among boys slightly depicted in the hierarchy of socio-economic positions of the society. As pubertal timing is connected with health-related behaviours – especially with smoking – the pacing of developmental transitions should be considered in planning programmes preventing unhealthy behavioural patterns often linked with negative attitudes towards schooling.

  12. Pubertal development in Danish children

    DEFF Research Database (Denmark)

    Juul, A; Teilmann, G; Scheike, Thomas Harder

    2006-01-01

    differences between USA and Denmark, as well as to look for possible secular trends in pubertal development. Healthy Caucasian children from public schools in Denmark participated in the study which was carried out in 1991-1993. A total number of 826 boys and 1,100 girls (aged 6.0-19.9 years) were included......Two recent epidemiological studies (PROS and NHANES III) from the USA noted earlier sexual maturation in girls, leading to increased attention internationally to the age at onset of puberty. We studied the timing of puberty in a large cohort of healthy Danish children in order to evaluate......, and pubertal stages were assessed by clinical examination according to methods of Tanner. In boys testicular volume was determined using an orchidometer. We found that age at breast development 2 (B2) was 10.88 years, and mean menarcheal age was 13.42 years. Girls with body mass index (BMI) above the median...

  13. The Effect of Pubertal and Psychosocial Timing on Adolescents' Alcohol Use: What Role Does Alcohol-Specific Parenting Play?

    Science.gov (United States)

    Schelleman-Offermans, Karen; Knibbe, Ronald A.; Engels, Rutger C. M. E.; Burk, William J.

    2011-01-01

    In scientific literature, early pubertal timing emerges as a risk factor of adolescents' drinking, whereas alcohol-specific rules (the degree to which parents permit their children to consume alcohol in various situations) showed to protect against adolescents' drinking. This study investigated whether alcohol-specific rules mediate and/or…

  14. Effects of Pubertal Timing on Communication Behaviors and Stress Reactivity in Young Women during Conflict Discussions with Their Mothers

    Science.gov (United States)

    Weichold, Karina; Buttig, Sabine; Silbereisen, Rainer K.

    2008-01-01

    Individuation, a process whereby adolescents gain autonomy from their parents while maintaining emotional relatedness, is displayed by characteristic styles of verbal exchanges. Negotiating this developmental transition is often stressful for adolescents and their parents. This study deals with the association between pubertal timing,…

  15. Recent changes in pubertal timing in healthy Danish boys: associations with body mass index

    DEFF Research Database (Denmark)

    Sørensen, Kaspar; Aksglaede, Lise; Petersen, Jørgen Holm;

    2010-01-01

    In the 1990s, the American population-based study NHANES III renewed the focus on possible secular trends in male puberty. However, no conclusions could be made on pubertal onset due to the lack of compatible data....

  16. The value of shoe size for prediction of the timing of the pubertal growth spurt

    Directory of Open Access Journals (Sweden)

    Verkerke Gijsbertus J

    2011-01-01

    Full Text Available Abstract Background Knowing the timing of the pubertal growth spurt of the spine, represented by sitting height, is essential for the prognosis and therapy of adolescent idiopathic scoliosis. There are several indicators that reflect growth or remaining growth of the patient. For example, distal body parts have their growth spurt earlier in adolescence, and therefore the growth of the foot can be an early indicator for the growth spurt of sitting height. Shoe size is a good alternative for foot length, since patients can remember when they bought new shoes and what size these shoes were. Therefore the clinician already has access to some longitudinal data at the first visit of the patient to the outpatient clinic. The aim of this study was to describe the increase in shoe size during adolescence and to determine whether the timing of the peak increase could be an early indicator for the timing of the peak growth velocity of sitting height. Methods Data concerning shoe sizes of girls and boys were acquired from two large shoe shops from 1991 to 2008. The longitudinal series of 242 girls and 104 boys were analysed for the age of the "peak increase" in shoe size, as well as the age of cessation of foot growth based on shoe size. Results The average peak increase in shoe size occurred at 10.4 years (SD 1.1 in girls and 11.5 years (SD 1.5 in boys. This was on average 1.3 years earlier than the average peak growth velocity of sitting height in girls, and 2.5 years earlier in boys. The increase in shoe size diminishes when the average peak growth velocity of sitting height takes place at respectively 12.0 (SD 0.8 years in girls, and 13.7 (SD 1.0 years in boys. Conclusions Present data suggest that the course of the shoe size of children visiting the outpatient clinic can be a useful first tool for predicting the timing of the pubertal growth spurt of sitting height, as a representative for spinal length. This claim needs verification by direct

  17. Pubertal development in Danish children

    DEFF Research Database (Denmark)

    Juul, A; Teilmann, G; Scheike, Thomas Harder

    2006-01-01

    Two recent epidemiological studies (PROS and NHANES III) from the USA noted earlier sexual maturation in girls, leading to increased attention internationally to the age at onset of puberty. We studied the timing of puberty in a large cohort of healthy Danish children in order to evaluate differe...... genetic polymorphisms, nutrition, physical activity or endocrine disrupting chemicals must therefore also be considered. Therefore, we believe it is crucial to monitor the pubertal development closely in Denmark in the coming decades.......Two recent epidemiological studies (PROS and NHANES III) from the USA noted earlier sexual maturation in girls, leading to increased attention internationally to the age at onset of puberty. We studied the timing of puberty in a large cohort of healthy Danish children in order to evaluate...

  18. Developmental variations in environmental influences including endocrine disruptors on pubertal timing and neuroendocrine control: Revision of human observations and mechanistic insight from rodents.

    Science.gov (United States)

    Parent, Anne-Simone; Franssen, Delphine; Fudvoye, Julie; Gérard, Arlette; Bourguignon, Jean-Pierre

    2015-07-01

    Puberty presents remarkable individual differences in timing reaching over 5 years in humans. We put emphasis on the two edges of the age distribution of pubertal signs in humans and point to an extended distribution towards earliness for initial pubertal stages and towards lateness for final pubertal stages. Such distortion of distribution is a recent phenomenon. This suggests changing environmental influences including the possible role of nutrition, stress and endocrine disruptors. Our ability to assess neuroendocrine effects and mechanisms is very limited in humans. Using the rodent as a model, we examine the impact of environmental factors on the individual variations in pubertal timing and the possible underlying mechanisms. The capacity of environmental factors to shape functioning of the neuroendocrine system is thought to be maximal during fetal and early postnatal life and possibly less important when approaching the time of onset of puberty.

  19. Nutrition and pubertal development

    Directory of Open Access Journals (Sweden)

    Ashraf Soliman

    2014-01-01

    Full Text Available Nutrition is one of the most important factors affecting pubertal development. Puberty entails a progressive nonlinear process starting from prepubescent to full sexual maturity through the interaction and cooperation of biological, physical, and psychological changes. Consuming an adequate and balanced healthy diet during all phases of growth (infancy, childhood and puberty appears necessary both for proper growth and normal pubertal development. Girls begin puberty at an earlier age compared to past decades. Excessive eating of many processed, high-fat foods, may be the cause of this phenomenon. Overweight or obese children are more likely to enter puberty early. Some evidence suggests that obesity can accelerate the onset of puberty in girls and may delay the onset of puberty in boys. Moreover, the progression of puberty is affected by nutrition. On the other hand, puberty triggers a growth spurt, which increases nutritional needs including macro and micronutrients. Increased caloric, protein, iron, calcium, zinc and folate needs have to be provided during this critical period of rapid growth. Severe primary or secondary malnutrition also can delay the onset and progression of puberty. The higher incidence of anorexia nervosa and bulimia in adolescents imposes a nutritional risk on pubertal development. Moreover, many environmental endocrine disruptors (EDs have been identified that can significantly impair the normal course of puberty. This mini-review sums up some important findings in this important complex that link nutrition and pubertal development.

  20. Forty years trends in timing of pubertal growth spurt in 157,000 Danish school children

    DEFF Research Database (Denmark)

    Aksglæde, Lise; Olsen, Lina Wøhlk; Sørensen, Thorkild I.A.;

    2008-01-01

    BACKGROUND: Entering puberty is an important milestone in reproductive life and secular changes in the timing of puberty may be an important indicator of the general reproductive health in a population. Too early puberty is associated with several psychosocial and health problems. The aim of our...... a secular trend towards earlier sexual maturation of Danish children born between 1930 and 1969. Only minor changes were observed in duration of puberty assessed by the difference in ages at OGS and PHV Udgivelsesdato: 2008...

  1. Pubertal development in healthy children is mirrored by DNA methylation patterns in peripheral blood

    DEFF Research Database (Denmark)

    Almstrup, Kristian; Johansen, Marie Lindhardt; Busch, Alexander S.

    2016-01-01

    Puberty marks numerous physiological processes which are initiated by central activation of the hypothalamic–pituitary–gonadal axis, followed by development of secondary sexual characteristics. To a large extent, pubertal timing is heritable, but current knowledge of genetic polymorphismsonly...... explains few months in the large inter-individual variation in the timing of puberty. We have analysed longitudinal genome-wide changes in DNA methylation in peripheral blood samples (n = 102) obtained from 51 healthy children before and after pubertal onset. We show that changes in single methylation...... sites are tightly associated with physiological pubertal transition and altered reproductive hormone levels. These methylation sites cluster in and around genes enriched for biological functions related to pubertal development. Importantly, we identified that methylation of the genomic region containing...

  2. The timing of normal puberty and the age limits of sexual precocity

    DEFF Research Database (Denmark)

    Parent, Anne-Simone; Teilmann, Grete; Juul, Anders

    2003-01-01

    During the past decade, possible advancement in timing of puberty has been reported in the United States. In addition, early pubertal development and an increased incidence of sexual precocity have been noticed in children, primarily girls, migrating for foreign adoption in several Western European...... countries. These observations are raising the issues of current differences and secular trends in timing of puberty in relation to ethnic, geographical, and socioeconomic background. None of these factors provide an unequivocal explanation for the earlier onset of puberty seen in the United States...

  3. Sexual Health in Prime Time

    Science.gov (United States)

    Taverner, William J.

    2006-01-01

    The term "sexual health" is often used in sexuality education without any concrete, operational definition, and students are left to ascertain the meaning for themselves. In the absence of a clear definition, students may adopt diverse or narrow understandings of this vague term, without learning the full scope of everything that sexual health…

  4. Racial disparities in pubertal development.

    Science.gov (United States)

    Ramnitz, Mary Scott; Lodish, Maya B

    2013-09-01

    The question of whether or not children, particularly girls, are entering puberty earlier than they did in the past has been a concern in both the medical community and the general population. A secular trend analysis of the current data on pubertal timing in boys and girls is limited by variations in the study design, the population assessed, and the methods used to determine pubertal development. These differences present a challenge when interpreting the available data, especially when comparing multiple studies. The influence of race on pubertal timing and development had not been assessed before the 1970s. The purpose of this article is to review the reported variations in pubertal timing among different racial/ethnic groups. Data suggest African American girls enter puberty earlier and reach menarche earlier than Caucasian and Hispanic girls. In addition, the trend toward earlier timing of puberty seems to be occurring faster in African American girls compared with Caucasian girls over the past 25 years. While the mechanism and understanding of the cause of racial disparities in pubertal development remain to be discerned, genetic and/or environmental factors may play a role and require further investigation.

  5. Sexually dimorphic stress and innate immunological responses of pre-pubertal Brahman cattle following an intravenous endotoxin challenge

    Science.gov (United States)

    This study was designed to characterize potential sexually dimorphic immunological responses following endotoxin challenge. Six female (heifers) and five male (bulls) Brahman calves (267 ± 11.5 days of age) were challenged with 0.25 microgram of LPS/kg body weight. Following administration of endoto...

  6. Male pubertal development: are endocrine-disrupting compounds shifting the norms?

    Science.gov (United States)

    Zawatski, William; Lee, Mary M

    2013-01-01

    Endocrine-disrupting compounds (EDCs) are synthetic or natural compounds that interfere with endogenous endocrine action. The frequent use of chemicals with endocrine active properties in household products and contamination of soil, water, and food sources by persistent chemical pollutants result in ubiquitous exposures. Wildlife observations and animal toxicological studies reveal adverse effects of EDCs on reproductive health. In humans, a growing number of epidemiological studies report an association with altered pubertal timing and progression. While these data are primarily reported in females, this review will focus on the small number of studies performed in males that report an association of polychlorinated biphenyls with earlier sexual maturity rating and confirm subtle effects of lead, dioxins, and endosulfan on delaying pubertal onset and progression in boys. Recent studies have also demonstrated that EDC exposure may affect pubertal testosterone production without having a noticeable effect on sexual maturity rating. A limitation to understand the effects of EDCs in humans is the potential for confounding due to the long temporal lag from early-life exposures to adult outcomes. The complex interplay of multiple environmental exposures over time also complicates the interpretation of human studies. These studies have identified critical windows of vulnerability during development when exposures to EDCs alter critical pathways and affect postnatal reproductive health. Contemporaneous exposures can also disrupt the hypothalamic-pituitary-gonadal axis. This paper will review the normal process of puberty in males and summarize human data that suggest potential perturbations in pubertal onset and tempo with early-life exposures to EDCs.

  7. Hormonal determinants of pubertal growth.

    NARCIS (Netherlands)

    Delamarre-van Waal, H.A.; Coeverden, S.C. van; Rotteveel, J.J.

    2001-01-01

    Pubertal growth results from increased sex steroid and growth hormone (GH) secretion. Estrogens appear to play an important role in the regulation of pubertal growth in both girls and boys. In girls, however, estrogens cannot be the only sex steroids responsible for pubertal growth, as exogenous est

  8. Pubertal assessment: a national survey of attitudes, knowledge and practices of the US pediatric trainees.

    Science.gov (United States)

    Khokhar, Aditi; Ravichandran, Yagnaram; Stefanov, Dimitre G; Perez-Colon, Sheila

    2017-07-06

    Background and objective Sex maturity rating (SMR), defines different levels of sexual maturity, based on the development of secondary sexual characteristics. Periodic assessment of pubertal maturation by physicians is crucial for timely identification of puberty-related disorders. With this pilot study, we aimed to assess the attitudes, knowledge and practices of pubertal assessment by current US pediatric trainees. Methods An anonymous online survey questionnaire was sent to categorical pediatric residents at different levels of training and pediatric chief residents across the US. Results We received responses from 2496 pediatric residents from all over the US. We found that 96% of trainees understand the importance of assessing SMR, 62% feel confident in assessing it and 55% feel comfortable assessing the need for an endocrinology referral. Only 33% of trainees performed external genital exams during all regular clinic visits while 26.9% never performed them during sick visits and 6% never assessed SMR during any of the patient visits. Higher levels of training and having completed an endocrinology rotation were associated with improvement in comfort level, practice and knowledge of trainees regarding pubertal assessment. Conclusion This study revealed that the current clinical practices of performing external genital exams and SMR among pediatric residents need improvement. Stronger reinforcement from continuity clinic preceptors and/or online and clinic based resources for SMR assessment for trainees may improve adherence to the recommended guidelines.

  9. Season of birth is associated with birth weight, pubertal timing, adult body size and educational attainment: a UK Biobank study

    Directory of Open Access Journals (Sweden)

    Felix R. Day

    2015-10-01

    Full Text Available Season of birth, a marker of in utero vitamin D exposure, has been associated with a wide range of health outcomes. Using a dataset of ∼450,000 participants from the UK Biobank study, we aimed to assess the impact of this seasonality on birth weight, age at menarche, adult height and body mass index (BMI. Birth weight, age at menarche and height, but not BMI, were highly significantly associated with season of birth. Individuals born in summer (June–July–August had higher mean birth weight (P = 8 × 10−10, later pubertal development (P = 1.1 × 10−45 and taller adult height (P = 6.5 × 10−9 compared to those born in all other seasons. Concordantly, those born in winter (December–January–February showed directionally opposite differences in these outcomes. A secondary comparison of the extreme differences between months revealed higher odds ratios [95% confidence intervals (CI] for low birth weight in February vs. September (1.23 [1.15–1.32], P = 4.4 × 10−10, for early puberty in September vs. July (1.22 [1.16–1.28], P = 7.3 × 10−15 and for short stature in December vs. June (1.09 [1.03–1.17], P = 0.006. The above associations were also seen with total hours of sunshine during the second trimester, but not during the first three months after birth. Additional associations were observed with educational attainment; individuals born in autumn vs. summer were more likely to continue in education post age 16 years (P = 1.1 × 10−91 or attain a degree-level qualification (P = 4 × 10−7. However, unlike other outcomes, an abrupt difference was seen between those born in August vs. September, which flank the start of the school year. Our findings provide support for the ‘fetal programming’ hypothesis, refining and extending the impact that season of birth has on childhood growth and development. Whilst other mechanisms may contribute to these associations, these findings are consistent with a possible role of in utero

  10. Three Quality Professional Documents to Guide Teachers for Puberty, Relationships and Sexuality Education

    Science.gov (United States)

    Goldman, Juliette D. G.; Collier-Harris, Christine A.

    2017-01-01

    Quality school-based sexuality education is important for all children and adolescents. The global trend towards students' earlier, longer, and technologically connected pubertal experience makes the timely provision of such education particularly significant. Quality international sexuality education documents are available for teachers…

  11. Human Papillomavirus Vaccination at a Time of Changing Sexual Behavior.

    Science.gov (United States)

    Baussano, Iacopo; Lazzarato, Fulvio; Brisson, Marc; Franceschi, Silvia

    2016-01-01

    Human papillomavirus (HPV) prevalence varies widely worldwide. We used a transmission model to show links between age-specific sexual patterns and HPV vaccination effectiveness. We considered rural India and the United States as examples of 2 heterosexual populations with traditional age-specific sexual behavior and gender-similar age-specific sexual behavior, respectively. We simulated these populations by using age-specific rates of sexual activity and age differences between sexual partners and found that transitions from traditional to gender-similar sexual behavior in women sexual behavior and that increased risk for HPV infection attributable to transition is preventable by early vaccination. Our study highlights the importance of using time-limited opportunities to introduce HPV vaccination in traditional populations before changes in age-specific sexual patterns occur.

  12. 中学生攻击行为与自感青春发动时相及学校因素的关系%Association of aggressive behavior with perceived pubertal timing and school factors in middle school students

    Institute of Scientific and Technical Information of China (English)

    俞荷俊; 乔淮燕; 张戎; 周英; 姚荣英

    2013-01-01

    目的 按不同性别探索中学生攻击行为与自感青春发动时相及学校因素的关系.方法 对2 791名中学生进行青春发育状况、攻击行为的问卷调查.结果 不同自感青春发动时相中学生攻击行为得分差异有统计学意义(F=14.676,P<0.05);不同学校风气、师生关系、同学关系、好朋友数中学生攻击行为得分差异有统计学意义(P<0.05);多重线性回归显示,男生攻击行为的影响因素为学校风气、自感青春发动时相、师生关系(β分别为-0.134、-0.114、-0.098,P<0.05);女生攻击行为的影响因素为师生关系、好朋友数、学校风气、自感青春发动时相(β分别为-0.120、-0.103、-0.102、-0.089,P<0.05).结论 自感青春发动时相及学校因素对中学生攻击行为的影响存在性别差异,在预防上应将时相偏离(提前或推迟)的男生,时相提前的女生列入重点对象.%Objective To explore the relationship between perceived pubertal timing together with school factors and the aggressive behavior in middle school students with different genders.Methods A total of 2 791 middle school students were surveyed by a questionnaire for youth development status and aggressive behavior.Results The score of aggressive behavior was significantly different in middle school students with different perceived pubertal timing (F =14.676,P < 0.05).The score of aggressive behavior was significantly different in middle school students with different general mood of school,relationship between classmates and teachers and the number of close friends (P < 0.05).Multiple linear regression analysis indicated that the influencing factors of male students' aggressive behavior were general mood of school,perceived pubertal timing and the relationship with teachers (β =-0.134,-0.114,-0.098,respectively,P < 0.05).The influencing factors of female students' aggressive behavior were the relationship with teachers,the number of

  13. Parenting Style and the Timing of Jewish Adolescents’ Sexual Debut

    Directory of Open Access Journals (Sweden)

    Robby Etzkin

    2010-06-01

    Full Text Available Parenting style and its effect on the timing of Jewish adolescents’ sexual debuts were examined in the reported study. One hundred sixty-eight research participants between the ages of 18 and 22 from a large university in the Southeast participated in the study. A survey instrument was administered at three fraternities and two sororities to examine parenting style and sexual debut retrospectively. Data were analyzed using descriptive statistics, frequency chi square tests, and Analysis of Variance (ANOVA; while post hoc results were determined through Tukey’s honestly significant difference. Results found that authoritative parenting provides a delay in the age of sexual debut for Jewish adolescents. All other parenting styles had mean ages less than the overall mean age of sexual debut, 17.10 years old, with indifferent parenting having the earliest debut. These findings suggest that parenting style may affect the timing of Jewish adolescents’ sexual debut. The study has implications for understanding factors that may affect the timing of a Jewish adolescent’s sexual debut and may help parents protect their adolescent from the negative effects associated with early sexual debut, such as low academic achievement. Recommendations for future research include exploring the effects of family structure and peer networks to understand fully the many factors that affect the timing of adolescents’ sexual debut.

  14. Pubertal Development, Personality, and Substance Use: A 10-Year Longitudinal Study From Childhood to Adolescence

    Science.gov (United States)

    Castellanos-Ryan, Natalie; Parent, Sophie; Vitaro, Frank; Tremblay, Richard E.; Séguin, Jean R.

    2013-01-01

    Most research linking early pubertal development to substance use has focused on the effects of pubertal timing (age at which a certain stage of pubertal development is reached or pubertal status at a particular age—related to the maturation disparity hypothesis), but little research has focused on pubertal tempo (rate of growth through pubertal stages—related to the maturation compression hypothesis). However, both timing and tempo have not only been identified as important components of pubertal development, with different predictors, but have also been shown to be independently associated with other adolescent psychopathologies. Using latent growth-curve modeling, this study examined how pubertal status at age 12 and pubertal tempo (between 11 and 13 years) related to substance use from 15 to 16 years in boys from low socioeconomic backgrounds (N = 871). Results showed that both pubertal status at age 12 and tempo were significant predictors of increased levels of substance use and problems in mid to late adolescence. In an attempt to identify mechanisms that may explain the association between pubertal development and substance use it was found that sensation seeking partially mediated the association between pubertal status at age 12 and substance use behaviors. Impulse control was found to moderate the association sensation seeking had with marijuana use frequency, with high sensation-seeking scores predicting higher marijuana use frequency only at low levels of impulse control. These findings highlight the importance of considering multiple sources of individual variability in the pubertal development of boys and provide support for both the maturational disparity and compression hypotheses. PMID:24016016

  15. Pubertal development, personality, and substance use: a 10-year longitudinal study from childhood to adolescence.

    Science.gov (United States)

    Castellanos-Ryan, Natalie; Parent, Sophie; Vitaro, Frank; Tremblay, Richard E; Séguin, Jean R

    2013-08-01

    Most research linking early pubertal development to substance use has focused on the effects of pubertal timing (age at which a certain stage of pubertal development is reached or pubertal status at a particular age--related to the maturation disparity hypothesis), but little research has focused on pubertal tempo (rate of growth through pubertal stages--related to the maturation compression hypothesis). However, both timing and tempo have not only been identified as important components of pubertal development, with different predictors, but have also been shown to be independently associated with other adolescent psychopathologies. Using latent growth-curve modeling, this study examined how pubertal status at age 12 and pubertal tempo (between 11 and 13 years) related to substance use from 15 to 16 years in boys from low socioeconomic backgrounds (N = 871). Results showed that both pubertal status at age 12 and tempo were significant predictors of increased levels of substance use and problems in mid to late adolescence. In an attempt to identify mechanisms that may explain the association between pubertal development and substance use it was found that sensation seeking partially mediated the association between pubertal status at age 12 and substance use behaviors. Impulse control was found to moderate the association sensation seeking had with marijuana use frequency, with high sensation-seeking scores predicting higher marijuana use frequency only at low levels of impulse control. These findings highlight the importance of considering multiple sources of individual variability in the pubertal development of boys and provide support for both the maturational disparity and compression hypotheses.

  16. Evidence of secular trend in mandibular pubertal growth.

    Science.gov (United States)

    Patcas, Raphael; Wiedemeier, Daniel B; Markic, Goran; Beit, Philipp; Keller, Heidi

    2017-04-20

    During puberty, mandibular growth follows a growth curve comparable to somatic growth. This study aimed to review the relationship between mandibular pubertal peak height velocity (PHV) and skeletal age, and to investigate the possibility of a secular trend. Retrospective analysis was performed of two historical craniofacial growth studies (Denver Growth Study; observational time: 1943-1965, and Zurich Growth Study; observational time: 1982-1984) of healthy untreated subjects. Two mandibular growth measures (Articulare-Pogonion [Ar-Pg], Condylion-Pogonion [Co-Pg]) were retrieved from cephalograms (n: 990) and corresponding skeletal age based on hand-wrist radiographs. Mandibular growth velocity was related to skeletal age, PHV was established by use of cubic smoothing splines and variability was calculated by bootstrap resampling for every growth study and gender separately. Sexual dimorphism in mandibular growth was apparent in both cohorts. In subjects of the Denver Growth Study, mandibular PHV occurred at a more advanced skeletal age than in subjects of the Zurich Growth Study. This trend was more pronounced in males, for whom PHV of Co-Pg shifted from 14.4 to 13.8 years and of Ar-Pg from 14.6 to 13.7 years. This tendency was more subtle in females: PHV of Co-Pg shifted from 12.7 to 12.4 years and of Ar-Pg from 12.6 to 11.8 years. Mandibular growth appears to be subject to a secular trend. When related to skeletal age, this secular trend seems to be more accentuated than the established secular trend for somatic pubertal growth.

  17. 青春发动时相提前与女生攻击行为的关联性分析%The correlation of the early pubertal timing and aggressive behavior of girls

    Institute of Scientific and Technical Information of China (English)

    俞荷俊; 周英; 顾璇; 朋文佳; 姚荣英

    2014-01-01

    目的:了解女中学生青春发动时相、攻击行为、外显自尊和亲子依恋的状况,探索青春发动时相与攻击行为之间的关联机制,揭示外显自尊和亲子依恋在青春发动时相提前与攻击行为中的中介作用。方法:采用问卷法,对1130名女中学生进行青春发育状况、攻击行为、外显自尊、亲子依恋的调查。结果:初中女生外显自尊和父子依恋的得分均高于高中女生(P<0.01),高中女生青春发育得分高于初中女生(P<0.05)。女中学生青春发动时相与攻击行为呈显著正相关关系(P<0.01),与母子依恋、外显自尊均呈负相关关系(P<0.05和P<0.01);外显自尊和母子依恋在青春发动时相提前对攻击行为的影响中起部分中介作用,中介作用大小分别为33.87%和25.98%。标准化回归系数7条显著路径,青春发动时相提前、外显自尊和母子依恋均对攻击行为有直接作用,同时青春发动时相提前通过外显自尊和母子依恋对攻击行为产生间接作用。结论:在攻击行为的预防上,引导青春发动时相提前的女中学生,正确把握自尊弹性,改善亲子依恋关系,可缓解和降低青春发动时相提前的女中学生的攻击行为水平。%Objective:To investigate of the early pubertal development,aggressive behavior,self-esteem and parent-child attachment of middle school girl,explore the mechanism of pubertal development and aggressive behavior,and reveal the intermediary role of selfesteem and parent-child attachment in the early pubertal timing and aggressive behavior of girls. Methods:The pubertal development, aggressive behavior,self-esteem and parent-child attachment of 1130 middle school girls were investigated by questionnaire. Results: The scores of self-esteem and parent-child attachment in middle school girls were higher than those in high school girls(P <0. 01),the score of pubertal development in high school girls was

  18. Endorsement and Timing of Sexual Orientation Developmental Milestones Among Sexual Minority Young Adults in the Growing Up Today Study.

    Science.gov (United States)

    Katz-Wise, Sabra L; Rosario, Margaret; Calzo, Jerel P; Scherer, Emily A; Sarda, Vishnudas; Austin, S Bryn

    2017-02-01

    This research examined endorsement and timing of sexual orientation developmental milestones. Participants were 1,235 females and 398 males from the Growing Up Today Study, ages 22 to 29 years, who endorsed a sexual minority orientation (lesbian/gay, bisexual, mostly heterosexual) or reported same-gender sexual behavior (heterosexual with same-gender sexual experience). An online survey measured current sexual orientation and endorsement and timing (age first experienced) of five sexual orientation developmental milestones: same-gender attractions, other-gender attractions, same-gender sexual experience, other-gender sexual experience, and sexual minority identification. Descriptive analyses and analyses to test for gender and sexual orientation group differences were conducted. Results indicated that women were more likely than men to endorse same-gender attraction, other-gender attraction, and other-gender sexual experience, with the most gender differences in endorsement among mostly heterosexuals and heterosexuals with same-gender sexual experience. In general, men reached milestones earlier than women, with the most gender differences in timing among lesbian and gay individuals and heterosexuals with same-gender sexual experience. Results suggest that the three sexual minority developmental milestones may best characterize the experiences of lesbians, gay males, and female and male bisexuals. More research is needed to understand sexual orientation development among mostly heterosexuals and heterosexuals with same-gender sexual experience.

  19. Timing of parent and child communication about sexuality relative to children's sexual behaviors.

    Science.gov (United States)

    Beckett, Megan K; Elliott, Marc N; Martino, Steven; Kanouse, David E; Corona, Rosalie; Klein, David J; Schuster, Mark A

    2010-01-01

    To examine timing of parent-child discussions about sexual topics relative to child-reported sexual behavior. Longitudinal study of employed parents and their children, with an initial survey followed by subsequent surveys 3, 6, and 12 months later. Participants were 141 parents, along with their children (13-17 years), who were control participants in a randomized, controlled trial to evaluate a worksite-based intervention to improve parent-adolescent communication. Main outcomes were parent and child reports of discussion of up to 24 sexual topics and presexual and sexual acts (ranging from handholding to vaginal intercourse) that occurred before the first survey and in the intervals between subsequent pairs of surveys. Sexual topics tend to group into 3 sets. The first set includes topics such as girls' bodies and menstruation and typically coincides with children's presexual stage (handholding, kissing). The second set includes topics such as birth control efficacy and refusing sex and typically coincides with the precoital stage (genital touching and oral sex). The third set typically occurs when children have initiated intercourse. Over half of children engage in genital touching before discussing birth control efficacy, resisting partner pressure for sex, sexually transmitted disease symptoms, condom use, choosing birth control, or partner condom refusal; >40% of children have intercourse before any discussion about sexually transmitted disease symptoms, condom use, choosing birth control, or partner condom refusal. Many parents and adolescents do not talk about important sexual topics before adolescents' sexual debut. Clinicians can facilitate this communication by providing parents with information about sexual behavior of adolescents.

  20. Time Out from Sex or Romance: Sexually Experienced Adolescents' Decisions to Purposefully Avoid Sexual Activity or Romantic Relationships.

    Science.gov (United States)

    Byers, E Sandra; O'Sullivan, Lucia F; Brotto, Lori A

    2016-05-01

    Researchers have given significant attention to abstinence among adolescents, but far less is known about purposeful avoidance of sexual activity (and relationship involvement). Typically, it is assumed that, once adolescents have initiated sexual activity, they will thereafter engage in sexual activity if given the opportunity. However, it is unclear whether that is true as some research indicates that many adolescents engage in sexual activity intermittently. Sexually experienced adolescents may purposefully avoid engaging in sexual activity for a period of time and, if so, this has implications for understanding their sexual decision-making. We used a mixed methods approach to investigate sexually experienced adolescents' decisions to purposefully avoid further sexual activity and/or romantic relationships with a focus on how common these decisions are and factors influencing them. Participants were 411 (56 % female) adolescents (16-21 years old) who completed an on-line survey that assessed reasons for each type of avoidance, religiosity, sexual esteem, sexual distress, sexual coercion, and dysfunctional sexual beliefs. Overall, 27 % of participants had engaged in sexual avoidance and 47 % had engaged in romantic avoidance. Significantly more female than male adolescents reported sexual and romantic avoidance. Adolescents' reasons for sexual avoidance included: lack of sexual pleasure or enjoyment, relationship reasons, negative emotions, values, fear of negative outcomes, negative physical experience, and other priorities. Reasons for romantic avoidance included: effects of previous relationship, not interested in commitment, wrong time, other priorities, negative emotions, no one was good enough, and sexual concerns. Logistical regressions were used to assess associations between age, religiosity, sexual esteem, sexual distress, experience of sexual coercion, and dysfunctional sexual beliefs and having engaged in romantic and/or sexual avoidance. The

  1. Age at pubertal onset and educational outcomes

    DEFF Research Database (Denmark)

    Essen, Emma von; Dreber, Anna; Ranehill, Eva

    2011-01-01

    Education has important short and long run implications for individual outcomes. In this paper we explore the association between age at pubertal onset and educational outcomes in a sample of Swedish girls. Previous research suggests that girls that mature earlier perform worse in school compared...... to girls that mature later. To test if this is also true among Swedish girls, we investigate the association between pubertal development and grades, educational aspirations and educational choice. We also investigate whether changes in risk attitudes, time preferences and priorities concerning school...... versus friends mediate this potential correlation. We confirm that earlier maturing girls have lower grades and lower educational aspirations, but find that they make educational choices similar to those of later maturing girls. Furthermore, we do not find that these differences in grades and aspirations...

  2. Update on statural growth and pubertal development in obese children

    Directory of Open Access Journals (Sweden)

    Chiara De Leonibus

    2012-12-01

    Full Text Available Childhood obesity is a growing and alarming problem, associated with several short-term and long-term metabolic and cardiovascular complications. In addition, it has also been suggested that excess adiposity during childhood influences growth and pubertal development. Several studies have shown that during pre-pubertal years, obese patients present higher growth velocity and that this pre-pubertal advantage tends to gradually decrease during puberty, leading to similar final heights between obese and non-obese children. Excess body weight might also influence pubertal onset, leading to earlier timing of puberty in girls. In addition, obese girls are at increased risk of hyperandrogenism and polycystic ovary syndrome. In boys, a clear evidence does not exist: some studies suggesting an earlier puberty associated with the obesity status, whereas other have found a delayed pubertal onset. Overall, the existing evidence of an association between obesity and modification of growth and pubertal patterns underlines a further reason for fighting the epidemics of childhood obesity.

  3. [Psychopathology related to women pubertal precocity].

    Science.gov (United States)

    Purper-Ouakil, D; Didillon, A

    2016-10-01

    associated with psychosocial stressors and at-risk environments. The early development of secondary sexual characteristics in girls attracts older and more deviant peers, raising probability of sexual contacts but also of drug use and of a disengagement in school activities. Adolescence is the life stage during which prevalence of depressive disorders rises significantly, especially in girls. Hormonal changes and increase of the Body Mass Index leading to dissatisfaction with body image, have been put forward to explain this trend. Psychosocial challenges (emerging sexuality, instability of identity and social role) are other sources of stress at this particular period of life characterized by emotional hyper-reactivity. These stressors may have greater impact in young people showing a discrepancy between physical and affective maturation. Follow-up studies have shown that emotional and behavioral problems tend to lessen with time. Nevertheless, a heightened risk of depressive disorder remains in girls having had an early onset of puberty when other risk factors co-exist. Early puberty, especially in girls, has been associated with a number of emotional and behavioral symptoms and difficulties in adaptive functioning. Even though these adverse outcomes seem to lessen with time, heightened risk for depression and negative impact on socio-professional outcomes persist in subjects with other risk factors. The impact of treatment of precocious puberty on psycho-behavioral outcomes is currently unknown. However, clinicians should be aware that the social and emotional challenges these adolescents with atypical pubertal development have to face put them at risk for psychopathology and are potentially accessible to preventive actions. Copyright © 2016 L'Encéphale, Paris. Published by Elsevier Masson SAS. All rights reserved.

  4. Pubertal assessment: targeted educational intervention for pediatric trainees.

    Science.gov (United States)

    Khokhar, Aditi; Nagarajan, Sairaman; Ravichandran, Yagnaram; Perez-Colon, Sheila

    2017-08-18

    Background Timely and periodic pubertal assessment in children is vital to identify puberty related disorders. Pediatricians need to have working knowledge of puberty time and tempo. Pediatric residency is an important platform to acquire physical examination skills including pubertal assessment. Objective An educational intervention for teaching pubertal assessment was piloted on pediatric residents at our institution. Methods The intervention comprised of interactive lecture series, ID badge size Tanner stage cards and Tanner posters placed in residents' continuity clinics. Pre-intervention, post-intervention and 3 months post-intervention surveys for participating trainees were administered to determine the effectiveness of the intervention. Attitudes, practices, knowledge scores, and barriers to Tanner staging conduct were analyzed. Results Forty-three residents participated in the intervention. Knowledge scores of PGY1 (5.95 ± 1.6 vs. 7.47 ± 1.4, p < 0.01) improved right after the intervention, as did self-reported clinical practices of all trainees 3 months post- intervention with regards to conducting external genital examination and performing pubertal assessment. Confidence levels of pediatric trainees in conducting pubertal assessment and comfort levels in assessing the need for endocrine referral based on abnormal Tanner staging improved after the intervention, although the effect was not statistically significant. Conclusion Our intervention is a worthwhile technique for teaching pubertal assessment to residents as it is simple to conduct, easily reproducible, provides baseline knowledge needed for recognition of normal pubertal development and puberty related conditions, and instills confidence in residents.

  5. BMI percentile-for-age overestimates adiposity in early compared with late maturing pubertal children

    DEFF Research Database (Denmark)

    Sørensen, Kaspar; Juul, Anders

    2015-01-01

    .041) was found with early compared with late maturation, despite similar BIA-estimated body fat percentage (BIA-BF%). Neither BMI nor BIA-BF% differed for a given stage of maturation. BMI percentile-for-age and prevalence of overweight/obesity were higher in the early compared with late matured pubertal children......OBJECTIVE: Early pubertal timing is consistently associated with increased BMI percentile-for-age in pubertal girls, while data in boys are more ambiguous. However, higher BMI percentile-for-age may be a result of the earlier puberty per se rather than vice versa. The aim was to evaluate markers...... of adiposity in relation to pubertal timing and reproductive hormone levels in healthy pubertal boys and girls. STUDY DESIGN: Population-based cross-sectional study (The Copenhagen Puberty Study). Eight-hundred and two healthy Caucasian children and adolescents (486 girls) aged 8.5-16.5 years participated. BMI...

  6. Dioxin Exposure and Age of Pubertal Onset among Russian Boys

    Science.gov (United States)

    Lee, Mary M.; Williams, Paige L.; Sergeyev, Oleg; Burns, Jane S.; Patterson, Donald G.; Turner, Wayman E.; Needham, Larry L.; Altshul, Larisa; Revich, Boris; Hauser, Russ

    2011-01-01

    Background: Animal data demonstrate associations of dioxin, furan, and polychlorinated biphenyl (PCB) exposures with altered male gonadal maturation. It is unclear whether these associations apply to human populations. Objectives: We investigated the association of dioxins, furans, PCBs, and corresponding toxic equivalent (TEQ) concentrations with pubertal onset among boys in a dioxin-contaminated region. Methods: Between 2003 and 2005, 499 boys 8–9 years of age were enrolled in a longitudinal study in Chapaevsk, Russia. Pubertal onset [stage 2 or higher for genitalia (G2+) or testicular volume (TV) > 3 mL] was assessed annually between ages 8 and 12 years. Serum levels at enrollment were analyzed by the Centers for Disease Control and Prevention, Atlanta, Georgia, USA. We used Cox proportional hazards models to assess age at pubertal onset as a function of exposure adjusted for potential confounders. We conducted sensitivity analyses excluding boys with pubertal onset at enrollment. Results: The median (range) total serum TEQ concentration was 21 (4–175) pg/g lipid, approximately three times higher than values in European children. At enrollment, boys were generally healthy and normal weight (mean body mass index, 15.9 kg/m2), with 30% having entered puberty by G2+ and 14% by TV criteria. Higher dioxin TEQs were associated with later pubertal onset by TV (hazard ratio = 0.68, 95% confidence interval, 0.49–0.95 for the highest compared with the lowest quartile). Similar associations were observed for 2,3,7,8-tetrachlorodibenzo-p-dioxin and dioxin concentrations for TV but not G2+. Results were robust to sensitivity analyses. Conclusions: Findings support an association of higher peripubertal serum dioxin TEQs and concentrations with later male pubertal onset reflected in delayed testicular maturation. PMID:21527364

  7. The timing and role of initiation rites in preparing young people for adolescence and responsible sexual and reproductive behaviour in Malawi.

    Science.gov (United States)

    Munthali, Alister C; Zulu, Eliya M

    2007-12-01

    This paper examines timing of puberty and mechanisms through which society prepares adolescents to understand and deal with it in Malawi. Data from a national representative survey of adolescents and in-depth interviews also conducted with adolescents are used. SPSS was used to analyse survey data while N6 was used to analyse qualitative data. Results show that the onset of menarche in girls and various pubertal body changes in boys can be a cause of joy, excitement, or distress depending on how adolescents understand what this means to them at this critical stage when they start defining and comprehending their sexuality. Much more emphasis is put on educating girls about reproductive implications of menarche than on what is expected of boys as sexual beings, which may contribute to boys' greater indulgence in risky sexual behaviors than girls. The significance of initiation ceremonies in some communities provides an important platform through which programs can reach many adolescents and intervene, particularly in addressing the widely held notion among initiates that attending these ceremonies symbolizes that one is not a child anymore and can have sex.

  8. The physiology and timing of male puberty

    DEFF Research Database (Denmark)

    Tinggaard, Jeanette; Mieritz, Mikkel Grunnet; Sørensen, Kaspar

    2012-01-01

    To describe available markers of male puberty, discuss associations between adiposity and pubertal timing and to review recent evidence of a possible secular trend in male pubertal timing.......To describe available markers of male puberty, discuss associations between adiposity and pubertal timing and to review recent evidence of a possible secular trend in male pubertal timing....

  9. Sexual development of prepubertal children.

    NARCIS (Netherlands)

    Graaf, H. de; Rademakers, J.

    2006-01-01

    Studies of childhood sexuality are scarce and often focus on sexual abuse. In this review, an attempt is made to establish what is known, from empirical studies, about sexual behaviors (solitary and interpersonal) and feelings in pre-pubertal boys and girls. In addition, the research methods used wi

  10. Macro-level age norms for the timing of sexual initiation and adolescents' early sexual initiation in 17 European countries

    NARCIS (Netherlands)

    Madkour, Aubrey Spriggs; de Looze, Margreet; Ma, Ping; Halpern, Carolyn Tucker; Farhat, Tilda; Ter Bogt, Tom F M; Ehlinger, Virginie; Nic Gabhainn, Saoirse; Currie, Candace; Godeau, Emmanuelle

    2014-01-01

    Purpose To examine the relationship between country-level age norms for sexual initiation timing and early sexual initiation (ESI) among adolescent boys and girls. Methods Nationally representative data from 17 countries that participated in the 2006/2007 European Social Survey (ESS-3, n = 33,092) a

  11. Sex steroids and brain structure in pubertal boys and girls.

    Science.gov (United States)

    Peper, Jiska S; Brouwer, Rachel M; Schnack, Hugo G; van Baal, G Caroline; van Leeuwen, Marieke; van den Berg, Stéphanie M; Delemarre-Van de Waal, Henriëtte A; Boomsma, Dorret I; Kahn, René S; Hulshoff Pol, Hilleke E

    2009-04-01

    Sex steroids exert important organizational effects on brain structure. Early in life, they are involved in brain sexual differentiation. During puberty, sex steroid levels increase considerably. However, to which extent sex steroid production is involved in structural brain development during human puberty remains unknown. The relationship between pubertal rises in testosterone and estradiol levels and brain structure was assessed in 37 boys and 41 girls (10-15 years). Global brain volumes were measured using volumetric-MRI. Regional gray and white matter were quantified with voxel-based morphometry (VBM), a technique which measures relative concentrations ('density') of gray and white matter after individual global differences in size and shape of brains have been removed. Results showed that, corrected for age, global gray matter volume was negatively associated with estradiol levels in girls, and positively with testosterone levels in boys. Regionally, a higher estradiol level in girls was associated with decreases within prefrontal, parietal and middle temporal areas (corrected for age), and with increases in middle frontal-, inferior temporal- and middle occipital gyri. In boys, estradiol and testosterone levels were not related to regional brain structures, nor were testosterone levels in girls. Pubertal sex steroid levels could not explain regional sex differences in regional gray matter density. Boys were significantly younger than girls, which may explain part of the results. In conclusion, in girls, with the progression of puberty, gray matter development is at least in part directly associated with increased levels of estradiol, whereas in boys, who are in a less advanced pubertal stage, such steroid-related development could not (yet) be found. We suggest that in pubertal girls, estradiol may be implicated in neuronal changes in the cerebral cortex during this important period of brain development.

  12. Urinary phthalate excretion in 555 healthy Danish boys with and without pubertal gynaecomastia

    DEFF Research Database (Denmark)

    Mieritz, Mikkel G; Frederiksen, Hanne; Sørensen, Kaspar;

    2012-01-01

    Pubertal gynaecomastia is a clinical sign of an oestrogen-androgen imbalance, which occurs in 40-60% of adolescent Caucasian boys. In most cases no underlying endocrinopathy can be identified. A recent study reports higher plasma phthalate levels in Turkish boys with pubertal gynaecomastia....... Therefore, we asked whether there was an association between concurrent measures of urinary phthalate metabolites and pubertal timing as well as the presence of gynaecomastia in otherwise healthy boys. We studied a total of 555 healthy boys (age 6.07-19.83 years) as part of the COPENHAGEN Puberty Study...

  13. Sexual Identity Development among Gay, Lesbian, and Bisexual Youths: Consistency and Change Over Time

    OpenAIRE

    Rosario, Margaret; Schrimshaw, Eric W.; Hunter, Joyce; Braun, Lisa

    2006-01-01

    A longitudinal report of 156 gay, lesbian, and bisexual youths examined changes in sexual identity over time. Fifty-seven percent of the youths remained consistently self-identified as gay/lesbian, 18% transited from bisexual to gay/lesbian, and 15% consistently identified as bisexual over time. Although youths who consistently identified as gay/lesbian did not differ from other youths on time since experiencing sexual developmental milestones, they reported current sexual orientation and sex...

  14. Breastfeeding versus formula-feeding and girls' pubertal development.

    Science.gov (United States)

    Kale, Aarti; Deardorff, Julianna; Lahiff, Maureen; Laurent, Cecile; Greenspan, Louise C; Hiatt, Robert A; Windham, Gayle; Galvez, Maida P; Biro, Frank M; Pinney, Susan M; Teitelbaum, Susan L; Wolff, Mary S; Barlow, Janice; Mirabedi, Anousheh; Lasater, Molly; Kushi, Lawrence H

    2015-03-01

    To examine the association of breastfeeding or its duration with timing of girls' pubertal onset, and the role of BMI as a mediator in these associations. A population of 1,237 socio-economically and ethnically diverse girls, ages 6-8 years, was recruited across three geographic locations (New York City, Cincinnati, and the San Francisco Bay Area) in a prospective study of predictors of pubertal maturation. Breastfeeding practices were assessed using self-administered questionnaire/interview with the primary caregiver. Girls were seen on at least annual basis to assess breast and pubic hair development. The association of breastfeeding with pubertal timing was estimated using parametric survival analysis while adjusting for body mass index, ethnicity, birth-weight, mother's education, mother's menarcheal age, and family income. Compared to formula fed girls, those who were mixed-fed or predominantly breastfed showed later onset of breast development [hazard ratios 0.90 (95 % CI 0.75, 1.09) and 0.74 (95 % CI 0.59, 0.94), respectively]. Duration of breastfeeding was also directly associated with age at onset of breast development (p trend = 0.008). Associations between breastfeeding and pubic hair onset were not significant. In stratified analysis, the association of breastfeeding and later breast onset was seen in Cincinnati girls only. The association between breast feeding and pubertal onset varied by study site. More research is needed about the environments within which breastfeeding takes place in order to better understand whether infant feeding practices are a potentially modifiable risk factor that may influence age at onset of breast development and subsequent risk for disease in adulthood.

  15. Breastfeeding versus Formula-Feeding & Girls’ Pubertal Development

    Science.gov (United States)

    Kale, Aarti; Deardorff, Julianna; Lahiff, Maureen; Laurent, Cecile; Greenspan, Louise C.; Hiatt, Robert A.; Windham, Gayle; Galvez, Maida P.; Biro, Frank M.; Pinney, Susan M.; Teitelbaum, Susan L.; Wolff, Mary S.; Barlow, Janice; Mirabedi, Anousheh; Lasater, Molly; Kushi, Lawrence H.

    2014-01-01

    Objective To examine the association of breastfeeding or its duration with timing of girls’ pubertal onset, and the role of BMI as a mediator in these associations. Methods A population of 1,237 socio-economically and ethnically diverse girls, ages 6–8 years, was recruited across three geographic locations (New York City, Cincinnati, and the San Francisco Bay Area) in a prospective study of predictors of pubertal maturation. Breastfeeding practices were assessed using self-administered questionnaire/interview with the primary caregiver. Girls were seen on at least annual basis to assess breast and pubic hair development. The association of breastfeeding with pubertal timing was estimated using parametric survival analysis while adjusting for body mass index, ethnicity, birth-weight, mother’s education, mother’s menarcheal age, and family income. Results Compared to formula fed girls, those who were mixed-fed or predominantly breastfed showed later onset of breast development (Hazard Ratios 0.90 [95% CI, 0.75–1.09] and 0.74 [95% CI, 0.59–0.94], respectively). Duration of breastfeeding was also directly associated with age at onset of breast development (p trend = 0.008). Associations between breastfeeding and pubic hair onset were not significant. In stratified analysis, the association of breastfeeding and later breast onset was seen in Cincinnati girls only. Conclusion The association between breast feeding and pubertal onset varied by study site. More research is needed about the environments within which breastfeeding takes place in order to better understand whether infant feeding practices are a potentially modifiable risk factor that may influence age at onset of breast development and subsequent risk for disease in adulthood. PMID:24916206

  16. Tracking of anthropometric parameters and bioelectrical impedance in pubertal boys and girls.

    Science.gov (United States)

    Leppik, Aire; Jürimäe, Toivo; Jürimäe, Jaak

    2006-12-01

    The aim of this study was to investigate the anthropometric parameters and body impedance once per year during four years of the pubertal period in Estonian children. In total, 81 boys and 86 girls aged 10-11 years at the beginning of the study were investigated. Pubertal status was self-assessed by sexual maturation stages according to Tanner and physical activity index (PAI) according to Telama et al.. Body height and weight were measured and body mass index (BMI) calculated. In total, 9 skinfolds, 13 girths, 8 lengths and 8 breadths/lengths were measured according to the protocol of the International Society for the Advancement of Kinanthropometry. Somatotype components were estimated according to the method of Carter and Heath. Body impedance was measured using Multiscan 5000 (Bodystat, UK) and the impedance index (height/impedance) was calculated. The tracking of body height, weight, BMI, skinfolds, girths, lengths, breadth/lengths and body impedance was high (as a rule r> or =0.9). By increasing the time period, the correlation slightly decreased. In contrast, tracking correlations for PAI and Tanner stages were significant but quite low. Increase in mean body height was highest between 12-13 years of age (6.9 cm per year) in boys and in girls between 11-12 years of age (6.3 cm per year). In boys and girls, the peak increase in body weight was between 11 and 12 years of age, 5.7 kg and 5.2 kg, respectively. With the increasing age, body impedance decreased and impedance index increased. In conclusion, our results indicate that during puberty the detailed anthropometric parameters and body impedance tracked highly. However, the tracking of PAI and Tanner stages was significant but relatively low.

  17. Effects of Di-(2-ethylhexyl) Phthalate on the Hypothalamus-Uterus in Pubertal Female Rats.

    Science.gov (United States)

    Liu, Te; Jia, Yiyang; Zhou, Liting; Wang, Qi; Sun, Di; Xu, Jin; Wu, Juan; Chen, Huaiji; Xu, Feng; Ye, Lin

    2016-11-12

    The pollution of endocrine disruptors and its impact on human reproductive system have attracted much attention. Di-(2-ethylhexyl) phthalate (DEHP), an environmental endocrine disruptor, is widely used in food packages, containers, medical supplies and children's toys. It can cause diseases such as infertility, sexual precocity and uterine bleeding and thus arouse concerns from the society and scholars. The effect of DEHP on pubertal female reproductive system is still not well-studied. This study was to investigate the effects of DEHP on the hypothalamus-uterus in pubertal female rats, reveal the reproductive toxicity of DEHP on pubertal female rats and its mechanism, and provide scientific evidence for the evaluation of toxicity and toxic mechanism of DEHP on reproductive system. Forty-eight pubertal female rats were randomly divided into four groups and respectively administered via oral gavage 0, 250, 500, or 1000 mg/kg/d DEHP in 0.1 mL corn oil/20 g body weight for up to four weeks. Compared with control rats, the DEHP-treated rats showed: (1) higher gonadotropin-releasing hormone (GnRH) level in the hypothalamus; (2) higher protein levels of GnRH in the hypothalamus; and (3) higher mRNA and protein levels of GnRH receptor (GnRHR) in the uterus. Our data reveal that DEHP exposure may lead to a disruption in pubertal female rats and an imbalance of hypothalamus-uterus. Meanwhile, DEHP may, through the GnRH in the hypothalamus and its receptor on the uterus, lead to diseases of the uterus. DEHP may impose a negative influence on the development and functioning of the reproductive system in pubertal female rats.

  18. Changes in the timing of sexual initiation among young Muslim and Christian women in Nigeria.

    Science.gov (United States)

    Agha, Sohail

    2009-12-01

    Sexual initiation during adolescence has important demographic and health consequences for a population, yet no systematic analysis of changes in the timing of sexual initiation has been conducted in Nigeria. Two rounds of national surveys conducted in 1990 and 2003 were used to examine changes in the timing of sexual initiation among female adolescents in Nigeria. Multivariate survival analysis using Cox proportional hazards models was used to assess changes in the risk of sexual initiation and to identify the correlates of first sex. Contrary to what has been reported in several Nigerian studies, there was no decline in age at first sex among Christian adolescents. Age at first sex did not change significantly for Christian adolescents, although premarital sex appears to have increased-primarily due to an increase in the age at marriage. Age at first sex did increase among Muslim women. Premarital sex remained low among Muslim women. A number of socioeconomic variables were associated with the timing of sexual initiation. Weekly exposure to the mass media was associated with earlier sexual initiation. The degree to which an environment was liberal or restrictive was a key determinant of the timing of sexual initiation in Nigeria. The findings also illustrate the important role of socioeconomic factors in determining the timing of sexual initiation in Nigeria. As secondary education increases in Northern Nigeria, additional increases in the age at sexual debut are likely among Muslim women. The study raises concerns about the influence of the mass media on the timing of first sex in Nigeria. The evidence of an absence of changes in the timing of sexual initiation among Christian women in more than a decade implies that programs which aim to delay the timing of sexual initiation in Southern Nigeria may have limited success. With age at marriage already high among Christian women, programs that focus on abstinence until marriage may also be pursuing an approach with

  19. DNA Methylation Patterns in the Hypothalamus of Female Pubertal Goats.

    Science.gov (United States)

    Yang, Chen; Ye, Jing; Li, Xiumei; Gao, Xiaoxiao; Zhang, Kaifa; Luo, Lei; Ding, Jianping; Zhang, Yunhai; Li, Yunsheng; Cao, Hongguo; Ling, Yinghui; Zhang, Xiaorong; Liu, Ya; Fang, Fugui

    2016-01-01

    Female pubertal development is tightly controlled by complex mechanisms, including neuroendocrine and epigenetic regulatory pathways. Specific gene expression patterns can be influenced by DNA methylation changes in the hypothalamus, which can in turn regulate timing of puberty onset. In order to understand the relationship between DNA methylation changes and gene expression patterns in the hypothalamus of pubertal goats, whole-genome bisulfite sequencing and RNA-sequencing analyses were carried out. There was a decline in DNA methylation levels in the hypothalamus during puberty and 268 differentially methylated regions (DMR) in the genome, with differential patterns in different gene regions. There were 1049 genes identified with distinct expression patterns. High levels of DNA methylation were detected in promoters, introns and 3'-untranslated regions (UTRs). Levels of methylation decreased gradually from promoters to 5'-UTRs and increased from 5'-UTRs to introns. Methylation density analysis demonstrated that methylation level variation was consistent with the density in the promoter, exon, intron, 5'-UTRs and 3'-UTRs. Analyses of CpG island (CGI) sites showed that the enriched gene contents were gene bodies, intergenic regions and introns, and these CGI sites were hypermethylated. Our study demonstrated that DNA methylation changes may influence gene expression profiles in the hypothalamus of goats during the onset of puberty, which may provide new insights into the mechanisms involved in pubertal onset.

  20. Effects of phytoestrogen on sexual development

    Directory of Open Access Journals (Sweden)

    Shin Hye Kim

    2012-08-01

    Full Text Available Phytoestrogen is an estrogenic compound that occurs naturally in plants. The most common sources of phytoestrogen are soybean products, which contain high levels of isoflavones. This compound, which has structural similarity with estrogen, can act as an estrogen receptor agonist or antagonist. Animal studies provide evidence of the significant effects of phytoestrogen on sexual development, including altered pubertal timing, impaired estrous cycling and ovarian function, and altered hypothalamus and pituitary functions. Although human studies examining the effects of phytoestrogen on sexual development are extremely limited, the results of some studies agree with those of the animal studies. In this paper, we review the possible mechanism of phytoestrogen action and the evidence showing the effects of phytoestrogen on sexual development in animal and human studies.

  1. A hierarchical linear modeling assessment of dual-addiction status and change in sexual compulsivity over time.

    Science.gov (United States)

    Wright, Paul J

    2010-08-01

    This study examined the association between dual-addiction status and sexual compulsivity over time in a sample of self-identified sexually compulsive males. Hierarchical linear modeling was utilized to address the study's research questions. Dually addicted sexually compulsive males exhibited lower rates of sexual compulsivity than their singularly addicted counterparts initially but displayed less precipitous declines in sexual compulsiveness over time. Implications for treatment providers are discussed.

  2. Macro-level Age Norms for the Timing of Sexual Initiation and Adolescents’ Early Sexual Initiation in 17 European Countries

    Science.gov (United States)

    Madkour, Aubrey Spriggs; de Looze, Margaretha; Ma, Ping; Halpern, Carolyn Tucker; Farhat, Tilda; ter Bogt, Tom F. M.; Ehlinger, Virginie; Nic Gabhainn, Saoirse; Currie, Candace; Godeau, Emmanuelle

    2014-01-01

    Purpose To examine the relationship between country-level age norms for sexual initiation timing and early sexual initiation (ESI) among adolescent boys and girls. Methods Nationally-representative data from 17 countries that participated in the 2006/07 European Social Survey (ESS-3, n=33,092) and the 2005/06 Health Behaviour in School-Aged Children Study (HBSC, n=27,702) were analyzed. Age norms were measured as the average country-level response to an item asking the age at which ESS respondents believed someone is too young to have sexual intercourse. HBSC respondents (aged 14-16) self-reported age at sexual initiation which we defined as early (<15 years) or not (≥15 years or no initiation). Control variables included age, family affluence, perceived socioeconomic status, family living arrangement, substance use, school attachment, and country-level legal age of consent. Multivariable three-level logistic models with random intercepts were run separately by sex. Results In multivariable analyses, higher overall age norms were associated with reduced likelihood of ESI among girls (AOR 0.60, 95% CI 0.45-0.79); associations with ESI were stronger for parent cohort (ages 31-65) norms (AOR 0.37, 95% CI 0.23-0.58) than for peer cohort (ages 15-20) norms (AOR 0.60, 95% CI 0.49-0.74). For boys, overall norms were also significantly negatively associated with ESI (AOR 0.68, 95% CI 0.46-0.99), as were parent cohort norms (AOR 0.66, 95% CI 0.45-0.96). Peer cohort norms were not significantly related to boys’ ESI. Conclusion Macro-level cultural norms may impact adolescents’ sexual initiation timing. Research exploring the sexual health outcomes of early initiators in countries with contrasting age norms is warranted. PMID:24508092

  3. Sexual identity development among gay, lesbian, and bisexual youths: consistency and change over time.

    Science.gov (United States)

    Rosario, Margaret; Schrimshaw, Eric W; Hunter, Joyce; Braun, Lisa

    2006-02-01

    A longitudinal report of 156 gay, lesbian, and bisexual youths examined changes in sexual identity over time. Fifty-seven percent of the youths remained consistently self-identified as gay/lesbian, 18% transited from bisexual to gay/lesbian, and 15% consistently identified as bisexual over time. Although youths who consistently identified as gay/lesbian did not differ from other youths on time since experiencing sexual developmental milestones, they reported current sexual orientation and sexual behaviors that were more same-sex centered and they scored higher on aspects of the identity integration process (e.g., more certain, comfortable, and accepting of their same-sex sexuality, more involved in gay-related social activities, more possessing of positive attitudes toward homosexuality, and more comfortable with others knowing about their sexuality) than youths who transited to a gay/lesbian identity and youths who consistently identified as bisexual. Contrary to the hypothesis that females are more sexually fluid than males, female youths were less likely to change identities than male youths. The finding that youths who transited to a gay/lesbian identity differed from consistently gay/lesbian youths suggests that identity integration continues after the adoption of a gay/lesbian sexual identity.

  4. Sexual Identity Development among Gay, Lesbian, and Bisexual Youths: Consistency and Change Over Time

    Science.gov (United States)

    Rosario, Margaret; Schrimshaw, Eric W.; Hunter, Joyce; Braun, Lisa

    2011-01-01

    A longitudinal report of 156 gay, lesbian, and bisexual youths examined changes in sexual identity over time. Fifty-seven percent of the youths remained consistently self-identified as gay/lesbian, 18% transited from bisexual to gay/lesbian, and 15% consistently identified as bisexual over time. Although youths who consistently identified as gay/lesbian did not differ from other youths on time since experiencing sexual developmental milestones, they reported current sexual orientation and sexual behaviors that were more same-sex centered and they scored higher on aspects of the identity integration process (e.g., more certain, comfortable, and accepting of their same-sex sexuality, more involved in gay-related social activities, more possessing of positive attitudes toward homosexuality, and more comfortable with others knowing about their sexuality) than youths who transited to a gay/lesbian identity and youths who consistently identified as bisexual. Contrary to the hypothesis that females are more sexually fluid than males, female youths were less likely to change identities than male youths. The finding that youths who transited to a gay/lesbian identity differed from consistently gay/lesbian youths suggests that identity integration continues after the adoption of a gay/lesbian sexual identity. PMID:16817067

  5. Sexuality and Aging: A Timely Addition to the Gerontology Curriculum.

    Science.gov (United States)

    Fitzpatrick, Tanya R.

    2000-01-01

    Describes the development and content of a course on sexuality in aging for a gerontology master's program. Topics include physical health, AIDS, gay/lesbian issues, widows/widowers, marriage, ethnic issues, menopause, and impotence. Provides a 33-item bibliography. (SK)

  6. Recent secular trends in pubertal timing

    DEFF Research Database (Denmark)

    Sørensen, Kaspar; Mouritsen, Annette; Aksglaede, Lise

    2012-01-01

    The decline in age at puberty in the general population has been paralleled by an increase in the number of girls referred for evaluation of precocious puberty (PP). In 1999, The Lawson Wilkins Pediatric Endocrine Society recommended a lowering of the age limit for evaluation of PP in girls. Howe...

  7. Sexual fantasies and viewing times across the menstrual cycle: a diary study.

    Science.gov (United States)

    Dawson, Samantha J; Suschinsky, Kelly D; Lalumière, Martin L

    2012-02-01

    Recent research has revealed that many aspects of female sexuality change across the menstrual cycle. In this study, we examined changes in sexual fantasies and visual sexual interests across the menstrual cycle. A total of 27 single, heterosexual women (M age=21.5 years) not using hormonal contraceptives answered questions on a web-based diary every day for 30 days about their sexual fantasies and behaviors. Twenty-two of them also completed a viewing time task during three different menstrual cycle phases (follicular, ovulation, and luteal) to assess changes in visual sexual interest. Ovulation status was determined by a self-administered urine test. Results showed that the frequency and arousability of sexual fantasies increased significantly at ovulation. The number of males in the fantasies increased during the most fertile period, with no such change for the number of females. Fantasy content became more female-like during ovulation, focusing more on emotions rather than explicit sexual content. Women displayed a category non-specific pattern of viewing time with regard to target age and gender, regardless of fertility status. Results were discussed in the context of the ovulatory shift hypothesis of female sexuality.

  8. [Contribution of anthropometric characteristics to pubertal stage prediction in young male individuals].

    Science.gov (United States)

    Medeiros, Radamés Maciel Vitor; Arrais, Ricardo Fernando; de Azevedo, Jenner Chrystian Veríssimo; do Rêgo, Jeferson Tafarel Pereira; de Medeiros, Jason Azevedo; de Andrade, Ricardo Dias; Dantas, Paulo Moreira Silva

    2014-09-01

    To identify the contribution of anthropometric variables to predict the maturational stage in young males. Cross-sectional study that enrolled 190 male subjects aged between eight and 18 years, randomly selected from public and private schools in Natal, Northeast Brazil. Thirty-two anthropometric variables were measured following the recommendations of the International Society for the Advancement of Kineanthropometry (ISAK). The assessment of sexual maturation was based on the observation of two experienced experts, who identified the pubertal development according to Tanner guidelines (1962). The anthropometric variables showed a significant increase of their values during the advancement of pubertal development (p<0.05). The following variables showed the best value for prediction of maturational groups: sitting height, femoral biepicondylar diameter, forearm girth, triceps skinfold, tibiale laterale and acromiale-radiale bone lenghts. These variables were able to estimate the pubertal stages in 76.3% of the sujects. The anthropometric characteristics showed significant differences between the moments of maturational stages, being found, representatively, seven variables that best predict the stages of sexual maturation. Copyright © 2014 Sociedade de Pediatria de São Paulo. Publicado por Elsevier Editora Ltda. All rights reserved.

  9. Nonresident fatherhood and adolescent sexual behavior: a comparison of siblings approach.

    Science.gov (United States)

    Ryan, Rebecca M

    2015-02-01

    Although voluminous research has linked nonresident fatherhood to riskier sexual behavior in adolescence, including earlier sexual debut, neither the causality of that link nor the mechanism accounting for it has been well-established. Using data from the National Longitudinal Survey of Youth, 1979-the Young Adult Survey (CNLSY-YA), the present study addresses both questions by comparing the sexual development of siblings discordant for age at father departure from the home and examining results across behavioral (age at first intercourse), biological (pubertal timing), and cognitive (attitudes about childbearing and marriage) sexual outcomes (N = 5,542). Findings indicate that nonresident fatherhood, beginning either at birth or during middle childhood, leads to an earlier sexual debut for girls, but not for boys, an effect likely explained by weak parental monitoring rather than an accelerated reproductive strategy. PsycINFO Database Record (c) 2015 APA, all rights reserved.

  10. Age at Time of Initial Sexual Intercourse and Health of Adolescent Girls.

    Science.gov (United States)

    Lara, Lúcia A S; Abdo, Carmita H N

    2016-10-01

    Adolescence is characterized by marked changes in the body, psychology, and sexual behavior due to increasing production of hormones. In this review we aimed to assess the effect of age at the time of first sexual intercourse (sexarche) on the health of adolescent girls, and identify factors that might protect against early initiation of sexual relations in girls. The PubMed, Lilacs, and Google Scholar databases were searched for clinical trials, comparative studies, case-control studies, cross-sectional studies, cohort studies, multicenter studies, observational studies, meta-analyses, and systematic reviews published up to December 2014 on this theme. The search terms were: "sexual debut," "coitarche," "sexarche," and "young people," "adolescent," "unplanned pregnancy," "adolescent contraception," and "STDs." Data were extracted from 28 studies and 41 references were used to introduce the theme and to support the discussion. Sexarche has been occurring in increasingly younger girls. A young age at sexarche can lead to subsequent risky sexual behavior. Girls who have sexarche when they are 14 years old or younger are less likely to use contraception on this occasion, take more time before they start using contraception in subsequent sexual relations, are more likely to have several sex partners, have a higher risk for depression, have lower self-esteem and more episodes of repentance, and have a higher risk for a sexually transmitted disease and cervical cancer. Girls with low educational, socioeconomic, and cultural status, little parental monitoring, parental separation, and absence of religiosity tend to experience sexarche at a younger age. Adolescent girls who postpone sexarche until they are 16 years old are physically and psychologically healthier than those who have sexarche at a younger age. This suggests that providing adolescent girls with appropriate education about sexual relations might reduce the negative effect of sexual relations at a young age.

  11. Sexually dimorphic body size and development time plasticity in Aedes mosquitoes (Diptera: Culicidae).

    Science.gov (United States)

    Wormington, Jillian D; Juliano, Steven A

    Sexual size dimorphism (SSD) in insects often accompanies a sexual difference in development time, sexual bimaturism (SBM). To determine whether three Aedes mosquito species have similar plasticity in SSD, attain sexual dimorphism through similar strategies, and whether SSD and SBM are associated. Aedes albopictus, Aedes aegypti, and Aedes triseriatus (Diptera: Culicidae). In four different food availability environments, we quantified plastic responses of relative growth rate (RGR), development time, and adult body size in individually reared males and females. Food availability affected RGR differently for the sexes for all three species. The RGR of males and females differed significantly in the 0.1 g/L food treatment. This difference did not account for observed SSD. Food levels over which the largest changes in RGR were observed differed among the species. Male and female adult mass and development time were jointly affected by food availability in a pattern that differed among the three species, so that degree of SSD and SBM changed differentially with food availability for all three species. Development time was generally less sexually dimorphic than mass, particularly in A. albopictus. At lower food levels, A. aegypti and A. triseriatus had accentuated dimorphism in development time. These results, combined with our knowledge of mosquito life history, suggest that a direct benefit of SBM is improbable for mosquitoes and that the observed intersexual differences in development time are more likely byproducts of selection for SSD.

  12. Advances in pubertal growth and factors influencing it: Can we increase pubertal growth?

    Directory of Open Access Journals (Sweden)

    Ashraf Soliman

    2014-01-01

    Full Text Available Puberty is a period of development characterized by partially concurrent changes which includes growth acceleration, alteration in body composition and appearance of secondary sex characteristics. Puberty is characterized by an acceleration and then deceleration in skeletal growth. The initiation, duration and amount of growth vary considerably during the growth spurt. Pubertal growth and biological maturation are dynamic processes regulated by a variety of genetic and environmental factors. Changes in skeletal maturation and bone mineral accretion concomitant with the stage of pubertal development constitute essential components in the evaluation of growth during this pubertal period. Genetic, endocrine and nutritional factors and ethnicity contribute variably to the amount of growth gained during this important period of rapid changes. Many studies investigated the possibility of increasing pubertal growth to gain taller final adult height in adolescents with idiopathic short stature (ISS. The pattern of pubertal growth, its relation to sex maturity rating and factors affecting them has been addressed in this review. The results of different trials to increase final adult height of adolescents using different hormones have been summarized. These data enables Endocrinologists to give in-depth explanations to patients and families about the efficacy and clinical significance as well as the safety of using these therapies in the treatment of adolescents with ISS.

  13. Putative effects of endocrine disrupters on pubertal development in the human

    DEFF Research Database (Denmark)

    Teilmann, Grete; Juul, Anders; Skakkebaek, Niels E

    2002-01-01

    Pubertal development is regulated by gonadotrophins and sex hormones. There has been a clear secular trend in the timing of puberty during the last century, puberty becoming earlier. Although improved nutrition is assumed to be the cause, this could partly be associated with exposure to so-called...

  14. On early starters and late bloomers: the development of sexual behavior in adolescence across personality types.

    Science.gov (United States)

    Baams, Laura; Overbeek, Geertjan; Dubas, Judith Semon; van Aken, Marcel A G

    2014-01-01

    Little is known about the relationship between personality and sexual development among mid-adolescents. In the current study, we used a person-centered approach to investigate the relation between personality types and the development of sexual behavior. We hypothesized that undercontrolling adolescents would engage in more advanced, casual, and risky sexual behavior compared to their resilient and overcontrolling peers. Data were used from 407 mid-adolescents (Mage = 14.5) followed across four measurement waves spanning 18 months. Results from latent class analyses (LCA) identified the three classical personality types: resilients, undercontrollers, and overcontrollers. Controlling for perceived pubertal timing and biological sex, latent growth curve analyses in Mplus showed that, at baseline, undercontrollers were more sexually experienced and engaged in more casual and risky sexual behavior than resilients and overcontrollers. Although initial levels of sexual behavior differed by personality types, over time increases in sexual behavior occurred at a similar rate across the types. Overall, the current study showed that undercontrolling adolescents are early sexual developers who engage in more advanced, casual, and risky sexual behavior than other adolescents. The implications of these findings for longer-term differences in sexual behavior between personality types in later adolescence are discussed.

  15. Assessment of circulating sex steroid levels in prepubertal and pubertal boys and girls by a novel ultrasensitive gas chromatography-tandem mass spectrometry method

    DEFF Research Database (Denmark)

    Courant, Frédérique; Aksglæde, Lise; Antignac, Jean-Philippe

    2010-01-01

    Estrogens and androgens play key roles for pubertal onset and sexual maturation. Most currently used immunoassays are not sensitive enough to accurately measure the low circulating levels of sex steroids in children without any signs of puberty. However, this does not exclude that sex steroids have...... important biological roles in prepubertal children....

  16. Assessment of circulating sex steroid levels in prepubertal and pubertal boys and girls by a novel ultrasensitive gas chromatography-tandem mass spectrometry method

    DEFF Research Database (Denmark)

    Courant, Frédérique; Aksglæde, Lise; Antignac, Jean-Philippe;

    2010-01-01

    Estrogens and androgens play key roles for pubertal onset and sexual maturation. Most currently used immunoassays are not sensitive enough to accurately measure the low circulating levels of sex steroids in children without any signs of puberty. However, this does not exclude that sex steroids ha...

  17. Contextual and Developmental Predictors of Sexual Initiation Timing among Mexican-Origin Girls

    Science.gov (United States)

    Bámaca-Colbert, Mayra Y.; Greene, Kaylin M.; Killoren, Sarah E.; Noah, Aggie J.

    2014-01-01

    Using data from a longitudinal study of Mexican-origin girls (ages 11-17 at Time 1), we examined sociocultural (i.e., family structure, nativity, and acculturation), interpersonal (i.e., supportive parenting and conflict), and developmental (i.e., menarche timing and autonomy expectations) predictors of sexual initiation. Using Cox proportional…

  18. Influence of Pubertal Timing to Adolescent Heterosexual Behaviors and Reproductive Health Information Seeking Practices%青春发动时相对于职校学生性行为及网络生殖健康信息获取的影响

    Institute of Scientific and Technical Information of China (English)

    张珊; 史慧静; 张越; 余春艳

    2011-01-01

    目的:分析青春发动时相对于职校学生性行为和网络生殖健康信息获取的影响.方法:在随机整群选取的1 846名中等职业技术学校学生中,问卷调查青春发育时间、异性间性行为、以及生殖健康信息获取经历.结果:青春发动时相提前男、女生的各种性行为自我报告率均显著高于适时组和延迟组.互联网是职校生寻求性生殖健康信息的重要来源之一,青春发动时相提前对于其网络性生殖健康信息寻求具有独立作用.结论:在开展有针对性的职校生性生殖健康教育中,尤其要关注和合理引导青春发动时相偏离正常的学生.%Objective: To investigate the influence of pubertal timing to vocational high school students' heterosexual behaviors as well as their practices of online seeking for reproductive health information.Methods: By using structural self-administered questionnaire, self-perceived pubertal timing, heterosexual behaviors, and perceived valuable and helpful ways of obtaining reproductive health information, as well as experiences of Internet surfing reproductive health information were obtained from a cluster-randomized sample of 1 864 vocational high school students in Shanghai.Results: Of various information sources of sex and reproductive health, Internet surfing was much more preferred and recognized by all respondents.In both males and females, self-reported rates of heterosexual behaviors in the earlier puberty group were significantly higher than those in the ordinary and delayed groups.Percentages of those vocational high school students, surfing online for sex and reproductive health knowledge were highest in earlier puberty group, followed by delayed group and ordinary group.The independent effect of pubertal timing on the sex and reproductive information seeking via Internet was existed even after controlling for age, sex, hours of internet use per day, selfperceived study achievement and averaged parents

  19. Sexual orientation and suicide attempt: a longitudinal study of the general Norwegian adolescent population.

    Science.gov (United States)

    Wichstrøm, Lars; Hegna, Kristinn

    2003-02-01

    Past and future suicide attempt rates among gay, lesbian, and bisexual (GLB) young people were compared with those of heterosexual young people. A sample of Norwegian students (N = 2.924; grades 7-12) was followed in 3 data collection waves. Risk factors included previous suicide attempt,depressed mood, eating problems, conduct problems, early sexual debut, number of sexual partners, pubertal timing, self-concept, alcohol and drug use, atypical gender roles, loneliness, peer relations, social support, parental attachment, parental monitoring, and suicidal behavior among family and friends. When homosexual attraction, homosexual identity, and same-sex sexual behavior were entered to predict suicide attempt, only same-sex sexual behavior was significantly predictive. The increased odds could not be attributed to GLB students' greater exposure to risk factors for suicide attempt.

  20. Portrayals of reproductive and sexual health on prime-time television.

    Science.gov (United States)

    Pariera, Katrina L; Hether, Heather J; Murphy, Sheila T; Buffington, Sandra de Castro; Baezconde-Garbanati, Lourdes

    2014-01-01

    Prime-time broadcast television provides health information and establishes norms for millions of people in the United States (Beck, 2004; Brodie et al., 2001; Murphy & Cody, 2003; Rideout, 2008). To understand what people may be learning about reproductive and sexual health, a content analysis was conducted of story lines from the 10 most popular prime-time television programs in 2009, 2010, and 2011. Variables that were measured included the frequency of reproductive and sexual health issues, the level of health information, the type of information portrayed, the gain and loss frames, the presence of stigma, the tone, and the type of role model portrayed. Eighty-seven of the 589 health story lines dealt with reproductive and sexual health, and the most common issues were pre- and postterm pregnancy complications. The majority of these story lines had a moderate or weak level of information and included specifics about treatment and symptoms but not prevention. Just over half of the issues were framed in terms of losses, meaning nonadoption of a behavior change will result in negative outcomes. Twenty-four percent of reproductive and sexual health story lines involved stigma-usually stigma related to sexually transmitted infections (STIs). Most story lines were portrayed as serious and the majority of issues happened to positive role models. The implications of these portrayals for the viewing public are discussed.

  1. Indirect Over-Time Relations Between Parenting and Adolescents' Sexual Behaviors and Emotions Through Global Self-Esteem.

    Science.gov (United States)

    van de Bongardt, Daphne; Reitz, Ellen; Deković, Maja

    2016-01-01

    The present study examined indirect over-time relations between parenting and adolescent sexuality through global self-esteem. Three waves of online questionnaire data were collected among a community sample of 1,116 Dutch adolescents (M = 13.9 years at baseline). Participants rated the quality of their relationship with parents, their global self-esteem, and their experience with various sexual behaviors. Sexually experienced adolescents (n = 168) evaluated their sexual experiences using six emotions. Path model results showed that a higher-quality relationship with parents at T1 predicted higher levels of self-esteem at T2, which in turn predicted less experience with sexual behaviors and more positive sexual emotions at T3. The indirect over-time path from relationship quality through self-esteem to adolescents' sexual emotions was significant; the indirect path to adolescents' experience with sexual behaviors was not significant at the .05 level. No significant age or gender differences were found in the path models. The findings indicate that self-esteem plays an important role in adolescent sexuality and that parents can contribute to positive sexual experiences of adolescents indirectly--through the enhancement of self-esteem--by fostering a high-quality relationship with their children. Implications for theory, future research, and strategies to promote healthy and positive youth sexuality are discussed.

  2. A combined form of hypothyroidism in pubertal patients with non-mosaic Klinefelter syndrome.

    Science.gov (United States)

    Tahani, Natascia; Ruga, Gilda; Granato, Simona; Spaziani, Matteo; Panimolle, Francesca; Anzuini, Antonella; Lenzi, Andrea; Radicioni, Antonio Francesco

    2017-02-01

    Klinefelter syndrome has been associated with thyroid abnormalities, the genesis of which is not yet fully clear. The aim of this study was to evaluate thyroid function in Klinefelter syndrome subjects during the pubertal period. Chemiluminescent microparticle immunoassay was used to analyze Thyroid-Stimulating Hormone, fT3 and fT4 concentration in serum samples from 40 Klinefelter syndrome pubertal boys with classic 47,XXY karyotype and 157 healthy age-matched controls. 13 Klinefelter syndrome patients also underwent Thyrotropin-Releasing Hormone testing to evaluate hypothalamic-pituitary function. fT3 levels were significantly lower in Klinefelter syndrome patients than in age-matched controls (p Klinefelter syndrome patients tended to cluster around the lower part of the reference range for the assay. Three of the thirteen Klinefelter syndrome patients undergoing the Thyrotropin-Releasing Hormone test had an adequate response, one had a prolonged response at 60 min and nine responded inadequately. This study demonstrated for the first time that pubertal Klinefelter syndrome patients have significantly lower fT3 serum levels than do healthy age-matched boys, whereas Thyroid-Stimulating Hormone and fT4 are normal, albeit at the lower end of the reference range. Most patients showed an inadequate/prolonged response to pituitary stimulation with Thyrotropin-Releasing Hormone. These findings suggest a combined form of both central and peripheral hypothyroidism in Klinefelter syndrome boys during pubertal development.

  3. [Insulin resistance and hyperinsulinemia--risk factors of the metabolic syndrome in the pubertal population].

    Science.gov (United States)

    Otto Buczkowska, Ewa

    2005-01-01

    Pubertal insulin resistance has been well documented, the fall in insulin sensitivity (Sl) during puberty is associated with a compensatory increase in insulin secretion. Observation of pubertal insulin resistance showed that insulin-stimulated glucose metabolism was approximately 30% lower in a sample of children at Tanner stages II-IV compared with children at Tanner stage I or adults. Although the phenomenon of pubertal insulin resistance is well documented, the mechanism has not been clearly determined. Pubertal insulin resistance occurs during a time of profound changes in body composition and hormone levels. Resistance of the body to the actions of insulin results in increased production of this hormone by the pancreas and ensuing hyperinsulinemia. Obesity beginning in childhood often precedes the hyperinsulinemic state. Other components of the insulin resistance syndrome are also present in children and adolescents. Conditions of insulin resistance, hyperinsulinemia, dyslipidemia, hypertension and obesity, especially in constellation, are potent risk factors of coronary atherosclerosis among adolescents and young adults. Early conservative intervention with diet, exercise, and behavioral therapy may prevent the complications of insulin resistance.

  4. Plasma Nesfatin-1 and Leptin in pubertal and non-pubertal Murrah buffalo heifers (Bubalus bubalis

    Directory of Open Access Journals (Sweden)

    Gorakh Nath Prajapati

    2015-12-01

    Full Text Available Buffaloes mostly suffer from delayed puberty, anestrus, sub–estrus, summer infertility, prolonged inter-calving interval and postpartum uterine disorders. Nesfatin-1 and Leptin are directly or indirectly related with body weight (BW, feed parameters and regulation of puberty. The objective of this study was to investigate the influence of Nesfatin-1 and Leptin in pubertal and non-pubertal Murrah buffalo heifers. The Murrah buffalo heifers (n=13 were randomly selected and divided into two groups; pubertal group (PG and non-pubertal group (NG. Heifers with plasma progesterone (P4 level of ≥1 ng/mL were classified as PG. Blood samples were collected at fortnight intervals for analysis of plasma Nesfatin-1, Leptin, P4, glucose and non-esterified fatty acids. Body weight, dry matter intake and feed conversion efficiency were recorded at fortnight intervals. The mean (±SEM plasma Nesfatin-1, Leptin, P4, BW and feed conversion efficiency (% were significantly (P<0.01 higher in PG as compared to NG. Dry matter intake by the heifers was also significantly (P<0.001 higher in PG than NG. Plasma metabolites (glucose and NEFA did not differ significantly between the groups. The findings of this study suggest that Nesfatin-1 and Leptin have indispensable role in the onset of puberty in buffalo heifers by affecting BW and feed parameters.

  5. Sexual Maturation Pattern in Adolescent School Girls of Rural India: A Cross Sectional Study from Nagpur

    Directory of Open Access Journals (Sweden)

    Dr. Charuhas V Akre

    2013-09-01

    Full Text Available Background: Puberty is transformation of the child into an adult. It includes all the events of somatic and mental maturation. Secondary sex characters were also a part of this period. The objective was to assess the pattern of sexual maturation of adolescent school girls in rural India.Methods: This was a community based cross sectional study conducted among school children of Sevanand High school, Mahadula, Nagpur. 322 girls in the age group of 10-18 years were assessed for sexual maturation. The pubertal evaluation was made with reference to Tanner stages and grading was done as per Tanner’s scale. For statistical analysis, median and standard error along with 95% confidence interval (CI were calculated using Epi Info statistical package programme version 6.0 updated 2009. Statistical significance was assessed at a type I error rate of 0.05.Results: We found that pubertal changes appeared earlier in girls. The first to appear was breast development at a median age of 10.40 years. The last to appear was pubic hair development (PH5 at median age 16.87 years, the total time taken for complete sexual maturation being 6.38 years. Median age of menarche was found to be13.18 years.Conclusion: The pattern of sexual maturation in rural adolescent school children revealed that though puberty set in earlier in girls, but took longer time for complete maturation.

  6. Dating Violence, Bullying, and Sexual Harassment: Longitudinal Profiles and Transitions over Time

    Science.gov (United States)

    Miller, Shari; Williams, Jason; Cutbush, Stacey; Gibbs, Deborah; Clinton-Sherrod, Monique; Jones, Sarah

    2013-01-01

    Although there is growing recognition of the problem of dating violence, little is known about how it unfolds among young adolescents who are just beginning to date. This study examined classes (subgroups) and transitions between classes over three time points based on dating violence, bullying, and sexual harassment perpetration and victimization…

  7. Early sexual intercourse: Prospective associations with adolescents physical activity and screen time

    NARCIS (Netherlands)

    Avelar e Silva, R.N. (Raquel Nogueira); A.I. Wijtzes (Anne); Van De Bongardt, D. (Daphne); P.M. van de Looij-Jansen (Petra); R. Bannink (Rienke); H. Raat (Hein)

    2016-01-01

    textabstractObjectives: To assess the prospective associations of physical activity behaviors and screen time with early sexual intercourse initiation (i.e., before 15 years) in a large sample of adolescents. Methods: We used two waves of data from the Rotterdam Youth Monitor, a longitudinal study c

  8. Early sexual intercourse : Prospective associations with adolescents physical activity and screen time

    NARCIS (Netherlands)

    Nogueira Avelar e Silva, R.; Wijtzes, A.; van de Bongardt, D.; van de Looij-Jansen, P.; Bannink, R.; Raat, H.

    2016-01-01

    Objectives: To assess the prospective associations of physical activity behaviors and screen time with early sexual intercourse initiation (i.e., before 15 years) in a large sample of adolescents. Methods: We used two waves of data from the Rotterdam Youth Monitor, a longitudinal study conducted in

  9. Parental Monitoring during Early Adolescence Deters Adolescent Sexual Initiation: Discrete-Time Survival Mixture Analysis

    Science.gov (United States)

    Huang, David Y. C.; Murphy, Debra A.; Hser, Yih-Ing

    2011-01-01

    We used discrete-time survival mixture modeling to examine 5,305 adolescents from the 1997 National Longitudinal Survey of Youth regarding the impact of parental monitoring during early adolescence (ages 14-16) on initiation of sexual intercourse and problem behavior engagement (ages 14-23). Four distinctive parental-monitoring groups were…

  10. The pubertal transition in 179 healthy Danish children

    DEFF Research Database (Denmark)

    Mouritsen, Annette; Aksglæde, Lise; Sørensen, Kaspar

    2013-01-01

    Pubertal onset is usually defined by breast development in girls and testicular growth in boys. Pubarche is defined as the attainment of pubic hair and is considered as a sign of pubertal transition. Pubarche is preceded by a gradual increase in production of adrenal androgens, DHEA and Δ4...

  11. Pubertal development in The Netherlands 1965-1997

    NARCIS (Netherlands)

    D. Mul (Dick); A.M. Fredriks; S. van Buuren (Stef); W. Oostdijk (Wilma); S.P. Verloove-Vanhorick; J.M. Wit (Jan)

    2001-01-01

    textabstractWe investigated pubertal development of 4019 boys and 3562 girls >8 y of age participating in a cross-sectional survey in The Netherlands and compared the results with those of two previous surveys. Reference curves for all pubertal stages were constructed. The 50th per

  12. Pubertal development in The Netherlands 1965-1997

    NARCIS (Netherlands)

    D. Mul (Dick); A.M. Fredriks; S. van Buuren (Stef); W. Oostdijk (Wilma); S.P. Verloove-Vanhorick; J.M. Wit (Jan)

    2001-01-01

    textabstractWe investigated pubertal development of 4019 boys and 3562 girls >8 y of age participating in a cross-sectional survey in The Netherlands and compared the results with those of two previous surveys. Reference curves for all pubertal stages were constructed. The 50th per

  13. Prevalence and incidence of precocious pubertal development in Denmark

    DEFF Research Database (Denmark)

    Teilmann, Grete; Pedersen, Carsten; Jensen, Tina Kold

    2005-01-01

    To our knowledge, no population-based epidemiologic studies on the incidence and prevalence of precocious pubertal development have been published. Danish national registries provide sufficient data for estimating the prevalence and incidence of this condition. The aim of this study was to estimate...... the prevalence and incidence of precocious pubertal development in Denmark in a 9-year period....

  14. Reproductive ability of pubertal male and female rats

    Directory of Open Access Journals (Sweden)

    T. Zemunik

    2003-07-01

    Full Text Available Ten Fisher rats 50 to 55 days of age made up the pubertal group, and ten rats 90 to 95 days of age served as the controls. The testicular and epididymal weights and volumes of the pubertal males were lower than those of the controls (P0.05. At the beginning of gestation, the pubertal dams weighed less than the controls (P<0.001 but following uterectomy the body weights were equal. Pubertal dams delivered fewer pups than the controls (8.1 ± 2.5 vs 10.4 ± 1.3, P<0.05. There was no difference in the body weights of their offspring or in the weights of their placentas. The results suggest that, in contrast to their female counterparts, pubertal male rats are not fully mature and have not reached complete reproductive capacity at 50-55 days of age.

  15. The association of peripubertal serum concentrations of organochlorine chemicals and blood lead with growth and pubertal development in a longitudinal cohort of boys: a review of published results from the Russian Children's Study.

    Science.gov (United States)

    Sergeyev, Oleg; Burns, Jane S; Williams, Paige L; Korrick, Susan A; Lee, Mary M; Revich, Boris; Hauser, Russ

    2017-02-23

    Organochlorine chemicals and lead are environmental exposures that have endocrine disrupting properties (EDCs) which interfere with many aspects of hormone action. Childhood and adolescence are windows of susceptibility for adverse health effects of EDCs. Our ongoing study, the Russian Children's Study (RCS), is one of the few longitudinal studies investigating the impact of EDCs on growth and puberty in boys. It is conducted in the historically contaminated city of Chapaevsk, in the Samara region. The study focuses on evaluating the associations of persistent organochlorine chemicals and lead with growth and pubertal timing. At enrollment in 2003-2005, we collected blood from 516 boys at ages 8-9 years to measure dioxins, furans, polychlorinated biphenyls (PCBs), chlorinated pesticides and lead. At enrollment and at annual visits through the ages of 18-19 years, a physician performed physical examinations that included pubertal staging and testicular volume measurements. We review the history of Chapaevsk as a research site and summarize published RCS data on the association of peripubertal serum concentrations of organochlorines and blood lead levels with growth, pubertal onset and sexual maturity. Overall, we found that persistent organochlorines and lead negatively affected growth during puberty. Our results also suggest that total toxic equivalents (TEQs), dioxin-like compounds, organochlorine pesticides and lead may delay, while nondioxin-like-PCBs may advance, the timing of male puberty. These findings promoted remediation programs in Chapaevsk, with improvement in health indicators, resulting in Chapaevsk being designated a member of the World Health Organization (WHO) network "Healthy Cities" in 2015.

  16. Time since first sexual intercourse and the risk of cervical cancer

    DEFF Research Database (Denmark)

    Plummer, Martyn; Peto, Julian; Franceschi, Silvia

    2012-01-01

    Young age at first sexual intercourse (AFI) is an important risk factor for cervical cancer, but no simple statistical model of its influence has been established. We investigated the relationship between risk of cervical carcinoma and time since first intercourse using data on monogamous women (5...... proportional to the square of time since first intercourse (exponent 1.95, 95% CI: 1.76-2.15) up to age 45. First cervical infection with human papillomavirus (HPV) often occurs soon after first sexual intercourse, so early AFI is a reasonable proxy for early age at first exposure to HPV. In addition, age......-specific incidence rates of cervical cancer in unscreened populations remain fairly constant above age 45. Cervical cancer thus resembles other cancers caused by strong early-stage carcinogens, with incidence rates proportional to a power of time since first exposure and also resembles cancers of the breast...

  17. Adolescents' increasing stress response to social evaluation: pubertal effects on cortisol and alpha-amylase during public speaking.

    Science.gov (United States)

    van den Bos, Esther; de Rooij, Mark; Miers, Anne C; Bokhorst, Caroline L; Westenberg, P Michiel

    2014-01-01

    Stress responses to social evaluation are thought to increase during adolescence, which may be due to pubertal maturation. However, empirical evidence is scarce. This study is the first to investigate the relation between pubertal development and biological responses to a social-evaluative stressor longitudinally. Participants performed the Leiden Public Speaking Task twice, with a 2-year interval (N = 217; age at Time 1: 8-17 years). The results support an increase in sensitivity to social evaluation during adolescence. The overall cortisol and alpha-amylase responses increased-both between and within participants-and were more strongly related to self-reported pubertal development than to age. The cortisol response shifted from speech delivery toward anticipation. The alpha-amylase response increased in both phases. © 2013 The Authors. Child Development © 2013 Society for Research in Child Development, Inc.

  18. Environmental Phenols And Pubertal Development In Girls

    Science.gov (United States)

    Wolff, Mary S.; Teitelbaum, Susan L.; McGovern, Kathleen; Pinney, Susan M.; Windham, Gayle C.; Galvez, Maida; Pajak, Ashley; Rybak, Michael; Calafat, Antonia M.; Kushi, Lawrence H.; Biro, Frank M.

    2015-01-01

    Environmental exposures to many phenols are documented worldwide and exposures can be quite high (>1 micromolar of urine metabolites). Phenols have a range of hormonal activity, but knowledge of effects on child reproductive development is limited, coming mostly from cross-sectional studies. We undertook a prospective study of pubertal development among 1239 girls recruited at three U.S. sites when they were 6–8 years old and were followed annually for 7 years to determine age at first breast or pubic hair development. Ten phenols were measured in urine collected at enrollment (benzophenone-3, enterolactone, bisphenol A, three parabens (methyl-, ethyl-, propyl-), 2,5-dichlorophenol, triclosan, genistein, daidzein). We used multivariable adjusted Cox proportional hazards ratios (HR (95% confidence intervals)) and Kaplan-Meier survival analyses to estimate relative risk of earlier or later age at puberty associated with phenol exposures. For enterolactone and benzophenone-3, girls experienced breast development 5–6 months later, adjusted HR 0.79 (0.64–0.98) and HR 0.80 (0.65–0.98) respectively for the 5th vs 1st quintiles of urinary biomarkers (μg/g-creatinine). Earlier breast development was seen for triclosan and 2,5- dichlorophenol: 4–9 months sooner for 5th vs 1st quintiles of urinary concentrations (HR 1.17 (0.96–1.43) and HR 1.37 (1.09–1.72), respectively). Association of breast development with enterolactone, but not the other three phenols, was mediated by body size. These phenols may be antiadipogens (benzophenone-3 and enterolactone) or thyroid agonists (triclosan and 2,5- dichlorophenol), and their ubiquity and relatively high levels in children would benefit from further investigation to confirm these findings and to establish whether there are certain windows of susceptibility during which exposure can affect pubertal development. PMID:26335517

  19. Does neighborhood environment influence girls' pubertal onset? findings from a cohort study

    Directory of Open Access Journals (Sweden)

    Deardorff Julianna

    2012-03-01

    Full Text Available Abstract Background Pubertal onset occurs earlier than in the past among U.S. girls. Early onset is associated with numerous deleterious outcomes across the life course, including overweight, breast cancer and cardiovascular health. Increases in childhood overweight have been implicated as a key reason for this secular trend. Scarce research, however, has examined how neighborhood environment may influence overweight and, in turn, pubertal timing. The current study prospectively examined associations between neighborhood environment and timing of pubertal onset in a multi-ethnic cohort of girls. Body mass index (BMI was examined as a mediator of these associations. Methods Participants were 213 girls, 6-8 years old at baseline, in an on-going longitudinal study. The current report is based on 5 time points (baseline and 4 annual follow-up visits. Neighborhood environment, assessed at baseline, used direct observation. Tanner stage and anthropometry were assessed annually in clinic. Survival analysis was utilized to investigate the influence of neighborhood factors on breast and pubic hair onset, with BMI as a mediator. We also examined the modifying role of girls' ethnicity. Results When adjusting for income, one neighborhood factor (Recreation predicted delayed onset of breast and pubic hair development, but only for African American girls. BMI did not mediate the association between Recreation and pubertal onset; however, these associations persisted when BMI was included in the models. Conclusions For African American girls, but not girls from other ethnic groups, neighborhood availability of recreational outlets was associated with onset of breast and pubic hair. Given the documented risk for early puberty among African American girls, these findings have important potential implications for public health interventions related to timing of puberty and related health outcomes in adolescence and adulthood.

  20. Impact of pubertal development on endothelial function and arterial elasticity.

    Science.gov (United States)

    Marlatt, Kara L; Steinberger, Julia; Dengel, Donald R; Sinaiko, Alan; Moran, Antoinette; Chow, Lisa S; Steffen, Lyn M; Zhou, Xia; Kelly, Aaron S

    2013-11-01

    Little is known about the relation of pubertal development on endothelial function and arterial elasticity in children and adolescents; therefore, we compared brachial artery flow-mediated dilation and carotid artery elasticity across Tanner (pubertal) stages in children and adolescents. Blood pressure, fasting lipids, glucose and insulin, body fat, insulin sensitivity adjusted for lean body mass, brachial flow-mediated dilation (percent dilation and area under the curve), endothelium-independent dilation (peak dilation and area under the curve), and carotid artery elasticity were evaluated across pubertal stages (Tanner I vs Tanner II-IV vs Tanner V) in 344 children and adolescents (184 males, 160 females; ages 6 to 21 years). One hundred twenty-four subjects (mean age 8.23 ± 0.15 years; 52 females) were Tanner stage I; 105 subjects (mean age 13.19 ± 0.17 years; 47 females) were Tanner stages II-IV; and 115 subjects (mean age 17.19 ± 0.16 years; 61 females) were Tanner stage V. There were no significant differences for any of the measures of vascular structure and function across pubertal stages. Results of the current study indicate that smooth-muscle and endothelial function, as well as carotid artery elasticity, do not differ throughout pubertal development and that accounting for pubertal stage when reporting vascular data in children and adolescents may be unnecessary. Copyright © 2013 Mosby, Inc. All rights reserved.

  1. Perception regarding pubertal changes among rural adolescent boys of Haryana: A school based study

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    Vinod Chayal

    2016-06-01

    Full Text Available Background: Adolescence is a transition phase through which a child matures into an adult. The physical changes in the human body are from infant to child to adolescence to adult to old age.  All phases of life behave like a coin with both good and bad facets attached to each phase of life. Aims & Objectives:  1. To study perception and awareness regarding pubertal changes among school going adolescent boys. 2. To study the association between education and perceived pubertal problems among study subjects. Material & Methods: The study was conducted among male students of senior secondary schools of community development block Beri in one year. The study universe comprised of students in middle and late adolescence (aged 14-18 years studying in 9th to 12th classes of the senior secondary schools in the area. A total of 1000 male students were selected from these schools which were more than the required sample size of 891. Results: The study found that 42.66% students and a half (50% of students of class 9th & 10th and class 11th & 12th respectively considered that pubertal changes as a normal phenomenon. The majority of students admitted practicing masturbation and felt shy and guilty for practicing masturbation, also students felt fatigued after night emission. Conclusions: The study concludes that adolescent’s sexuality which often causes controversy and concern among adults is least discussed with them during adolescence. The reasons for this may be many, including moral grounds or because of concomitant health risks and threats to wellbeing.

  2. Predicting different patterns of sexual identity development over time among lesbian, gay, and bisexual youths: a cluster analytic approach.

    Science.gov (United States)

    Rosario, Margaret; Schrimshaw, Eric W; Hunter, Joyce

    2008-12-01

    Recent research has suggested that the sexual identity development of lesbian, gay, and bisexual (LGB) youths may not follow a single pattern, but may follow a variety of pathways. Although some research documenting variability in identity development exists, unclear are the potential individual and social contexts that predict these different patterns, as well as the contexts that predict changes in identity integration over time. This report longitudinally examined these issues in an ethnically diverse sample of 156 LGB youths (ages 14-21) in New York City. Cluster analytic techniques identified two patterns of sexual identity formation (i.e., early and more recent), and three patterns of sexual identity integration (i.e., high, middling, and low). Gender and sexual abuse were found to predict identity formation; and, gay-related stress, social support, negative social relationships, sexual orientation, sexual identity, and gender were found to predict patterns of sexual identity integration and changes in integration over 1 year. These findings document different patterns of sexual identity development and identify potential contextual barriers and facilitating factors that may be used to develop interventions to promote healthy LGB identity development.

  3. Pubertal development among girls with classical congenital adrenal hyperplasia initiated on treatment at different ages

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    Bindu Kulshreshtha

    2012-01-01

    Full Text Available Introduction: Children with congenital adrenal hyperplasia (CAH provide us an opportunity to study the clinical effects of androgen excess in humans. We studied the sequence of pubertal development in girls with congenital adrenal hyperplasia initiated on treatment at different ages, to assess the effects of androgen exposure on the Hypothalamic-Pituitary-Ovarian (HPO axis. Materials and Methods: Girls more than 18 years of age, with CAH, on follow-up at this hospital were the subjects for this study. Details of history, physical findings, laboratory evaluation, and medication were noted from their case records and verified from the patients and their / parents, in addition to assessment of their present health status. Result: We studied 24 patients of classical CAH (SW-2, SV-22, average age - 24.5 ± 6.6 years. All had varying degrees of genital ambiguity (Prader stage 3 (n = 13, Prader stage 2 (n = 10, Prader stage 1 (n = 1. Among them were13 girls, who were started on steroids after eight years of age. Girls who received treatment from infancy and early childhood had normal pubertal development (mean age at menarche 11.4 ± 1.7 years. Hirsutism was not a problem among them. Untreated children had progressive clitoral enlargement throughout childhood, developed pubic hair at around three to six years of age, and facial hair between nine and eleven years. Plasma testosterone ranged from 3 to 6 ng / ml prior to treatment. Six of the 13 untreated CAH girls had subtle breast development starting at ages 11 - 16 years and three had spontaneous infrequent vaginal bleeding starting at ages 11 - 17. Steroid supplementation initiated pubertal changes in older girls in two-to-six months′ time. Conclusion: There was a delay in HPO axis maturation (as evidenced by delayed pubertal development in the absence of treatment in girls with CAH. This could be corrected with steroid supplementation.

  4. Pubertal development in adolescents with menstrual disorders

    Directory of Open Access Journals (Sweden)

    Alberto Roteta Dorado

    2010-07-01

    Full Text Available Introduction: Abnormal uterine bleeding is the presence of an excessive and prolonged menstrual bleeding over several consecutive cycles. It is one of the first complaints in pediatric gynecology and is the most common cause dysfunctional uterine bleeding. Objective: To characterize adolescents with menstrual disorders attending gynecology clinic in child and adolescent onset of puberty. Method: A descriptive, longitudinal and prospective. Universe: 88 adolescents seen at the gynecology children and youth in the province of Cienfuegos with menstrual disorders in 2008. Sample: 64 patients with rhythm disturbances of the menstrual cycle and excessive bleeding. Procedure: During the first consultation was found in the following medical records: age, onset of puberty, age at menarche, breast development and pubic hair development. The data were processed by SPSS program and expressed as numbers and percentages. Results: 43.8% of the adolescents studied were between 14 and 16 years, 29.7% began puberty at age 9, 31.3% had their menarche at age 11, 46, 87% were in Tanner stage IV of breast development and 56.25% in Tanner stage IV for pubic hair. Conclusion: There were no alterations in pubertal development in adolescents with menstrual disorders studied.

  5. Blooming Sexuality : A Biopsychosocial Perspective on Adolescent Romantic and Sexual Development

    NARCIS (Netherlands)

    Baams, L.

    2015-01-01

    The aim of this dissertation was to examine adolescent romantic and sexual development, in a biopsychosocial model, in which physical, psychological, and social contextual factors are considered. The findings of this dissertation show the importance of individual factors such as pubertal status and

  6. Blooming Sexuality : A Biopsychosocial Perspective on Adolescent Romantic and Sexual Development

    NARCIS (Netherlands)

    Baams, L.

    2015-01-01

    The aim of this dissertation was to examine adolescent romantic and sexual development, in a biopsychosocial model, in which physical, psychological, and social contextual factors are considered. The findings of this dissertation show the importance of individual factors such as pubertal status and

  7. The dynamics of bone structure development during pubertal growth.

    Science.gov (United States)

    Rauch, F

    2012-03-01

    The pubertal growth spurt is a time of rapid changes in bone length, mass and structure, followed by the cessation of longitudinal growth. The two best studied anatomical areas in this respect are the metaphyses and the diaphyses of peripheral long bones. A model is presented here in which the speed of longitudinal growth and the resulting age gradient in metaphyseal bone are key factors in explaining the high incidence of distal radius fractures during puberty. As growth in length accelerates, the age of the bone structural elements at a given distance to the growth plate decreases, leaving less time for cortical thickening through trabecular coalescence. This leads to a discrepancy between stagnant metaphyseal bone strength and increasing mechanical requirements in the case of accidents. In comparison to the metaphysis, diaphyseal bone develops more in line with the increasing mechanical requirements, presumably because the bone formation rates needed for diaphyseal growth in width are only a fraction of the apposition rates in the metaphysis. It remains largely unexplored how local and systemic signals are integrated to achieve site-specific changes in bone structure.

  8. First Time: Characteristics of Teens' First Sexual Relationships. Child Trends Research Brief.

    Science.gov (United States)

    Ryan, Suzanne; Manlove, Jennifer; Franzetta, Kerry

    Understanding characteristics of teens' sexual relationships may help us to better understand how to reduce teens' risk of early unintended pregnancy and sexually transmitted diseases (STDs), as well as the psychological and emotional problems that may be associated with teenage romantic relationships and sexual activity. Using data from the…

  9. Candidate gene expression in Bos indicus ovarian tissues: pre-pubertal and post-pubertal heifers in diestrus

    Directory of Open Access Journals (Sweden)

    Mayara Morena Del Cambre Amaral Weller

    2016-10-01

    Full Text Available Growth factors such as bone morphogenetic proteins 6, 7, 15 and two isoforms of transforming growth factor-beta (BMP6, BMP7, BMP15, TGFB1 and TGFB2 and insulin-like growth factor system act as local regulators of ovarian follicular development. To elucidate if these factors as well as others candidate genes such as estrogen receptor 1 (ESR1, growth differentiation factor 9 (GDF9, follicle stimulating hormone receptor (FSHR, luteinizing hormone receptor (LHR, bone morphogenetic protein receptor, type 2 (BMPR2, type 1 insulin-like growth factor receptor (IGFR1, and key steroidogenic enzymes cytochrome P450 aromatase and 3-β-hydroxysteroid dehydrogenase (CYP19A1 and HSD3B1 could modulate or influence diestrus on the onset of puberty in Brahman heifers, their ovarian mRNA expression was measured before and after puberty (luteal phase. Six post-pubertal (POST heifers were euthanized on the luteal phase of their second cycle, confirmed by corpus luteum observation, and six pre-pubertal (PRE heifers were euthanized in the same day. Quantitative real-time PCR analysis showed that the expression of FSHR, BMP7, CYP19A1, IGF1 and IGFR1 mRNA was greater in PRE heifers, when contrasted to POST heifers. The expression of LHR and HSD3B1 was lower in PRE heifers. Differential expression of ovarian genes could be associated with changes in follicular dynamics and different cell populations that have emerged as consequence of puberty and the luteal phase. The emerging hypothesis is that BMP7 and IGF1 are co-expressed and may modulate the expression of FSHR, LHR and IGFR1 and CYP19A1. BMP7 could influence the down-regulation of LHR and up-regulation of FSHR and CYP19A1, which mediates the follicular dynamics in heifer ovaries. Up-regulation of IGF1 expression pre-puberty, compared to post-puberty diestrus, correlates with increased levels FSHR and CYP19A1. Thus, BMP7 and IGF1 may play synergic roles and were predicted to interact, from the expression data (P = 0

  10. Two leptin genes and a leptin receptor gene of female chub mackerel (Scomber japonicus): Molecular cloning, tissue distribution and expression in different obesity indices and pubertal stages.

    Science.gov (United States)

    Ohga, Hirofumi; Matsumori, Kojiro; Kodama, Ryoko; Kitano, Hajime; Nagano, Naoki; Yamaguchi, Akihiko; Matsuyama, Michiya

    2015-10-01

    Leptin is a hormone produced by fat cells that regulates the amount of fat stored in the body and conveys nutritional status to the reproductive axis in mammals. In the present study we identified two subtypes of leptin genes (lepa and lepb) and a leptin receptor gene (lepr) from chub mackerel (Scomber japonicus) and there gene expression under different feeding conditions (control and high-feed) and pubertal development stages was analyzed using quantitative real-time PCR. The protein lengths of LepA, LepB and LepR were 161 amino acids (aa), 163 aa and 1149 aa, respectively and both leptin subtypes shared only 15% similarity in aa sequences. In pubertal females, lepa was expressed in the brain, pituitary gland, liver, adipose tissue and ovary; however, in adult (gonadal maturation after the second in the life) females, lepa was expressed only in the liver. lepb was expressed primarily in the brain of all fish tested and was expressed strongly in the adipose tissue of adults. lepr was characterized by expression in the pituitary. The high-feed group showed a high conditioning factor level; unexpectedly, hepatic lepa and brain lepr were significantly more weakly expressed compared with the control-feed group. Furthermore, the expression levels of lepa, lepb and lepr genes showed no significant differences between pre-pubertal and post-pubertal fish. On the other hand, pituitary fshβ and lhβ showed no significant differences between different feeding groups of pre-pubertal fish. In contrast, fshβ and lhβ expressed abundantly in the post-pubertal fish of control feed group. Based on these results, whether leptin plays an important role in the nutritional status and pubertal onset of chub mackerel remains unknown.

  11. The Sexual Function Questionnaire's Medical Impact Scale (SFQ-MIS): validation among a sample of first-time mothers.

    Science.gov (United States)

    Jawed-Wessel, Sofia; Schick, Vanessa; Herbenick, Debby

    2013-11-01

    Changes in sexual function can be difficult to capture, especially when an attempt is made to assess the effects of pregnancy or childbirth on the sexual function of first-time mothers. Commonly used sexual function measures are limited and fail to account for pregnancy or birth in assessment of function. The purpose of this study was to explore the utility of the Sexual Function Questionnaire Medical Impact Scale (SFQ-MIS) in assessing impact of childbirth on sexual function among first-time mothers with infants aged one year or younger. A total of 255 women completed a cross-sectional, web-based survey. Exploratory factor analysis was utilized to assess the factor structure of the SFQ-MIS scores in this sample. Variations in SFQ-MIS scores based upon participant characteristics were conducted to further evaluate the SFQ-MIS scores. SFQ-MIS score was the primary measure of interest. Factors related to pregnancy and childbirth, such as mode of delivery, infant date of birth, last menstrual period, need for an episiotomy or perineal stitches, breastfeeding status, and score on the Perceived Stress Scale, were also assessed in order to further evaluate the validity and predictive capacity of the SFQ-MIS. Results indicated one factor that accounted for 58.27% of the variance in impact on sexual function due to childbirth. Cronbach's α coefficient for all five items was acceptable (0.82). Women who were breastfeeding (PMIS appears to be a useful and valid indicator of changes in sexual function following childbirth, such as those related to arousal, desire, and orgasm. © 2013 International Society for Sexual Medicine.

  12. Skin surface lipid composition, acne, pubertal development, and urinary excretion of testosterone and 17-ketosteroids in children.

    Science.gov (United States)

    Pochi, P E; Strauss, J S; Downing, D T

    1977-11-01

    Fifty-two children, age 5-10, from acne-prone families, were studied for a period of 1 year to examine the interrelationship between sebum, acne, pubertal development, and urinary steroid excretion. In each of the subjects, 30 boys and 22 girls, the composition of forehead skin lipid was determined 4 times yearly by thin-layer chromatography, with measurement of triglycerides, diglycerides, free fatty acids, wax esters, squalene, cholesterol, and cholesterol esters. Twice yearly, examination was made of the presence or absence of acne, pubertal maturation and the 24-hour urinary excretion of testosterone as determined by radioimmunnoassay, and of total 17-ketosteroids, dehydroepiandrosterone, androsterone, and etiocholanolone, as determined by paper chromatography. The relative amount of sebaceous lipids was positively correlated with age of the subjects (wax esters p less than .001, squalene p less than .05), as was the triglyceride-diglyceride component (p less than .05). No significant correlation was seen with the fatty acids. Acne, primarily comedonal, occurred in 27/52 subjects (15 girls, 12 boys) and was associated with higher sebum values. One-half of the children with acne had no signs of pubertal development. A significantly positive correlation was observed between the relative amount of sebaceous lipid and the urinary excretion of 17-ketosteroids, androsterone, and etiocholanolone in both sexes, and of testosterone and dehydroepiandrosterone in boys. The development of acne in children is an early pubertal event, often evident before other signs of pubertal maturation, and it is associated with an increase in sebum and in the urinary excretion of androgenic steroids.

  13. The sexual phase of the diatom Pseudo-nitzschia multistriata: cytological and time-lapse cinematography characterization.

    Science.gov (United States)

    Scalco, Eleonora; Amato, Alberto; Ferrante, Maria Immacolata; Montresor, Marina

    2016-11-01

    Pseudo-nitzschia is a thoroughly studied pennate diatom genus for ecological and biological reasons. Many species in this genus, including Pseudo-nitzschia multistriata, can produce domoic acid, a toxin responsible for amnesic shellfish poisoning. Physiological, phylogenetic and biological features of P. multistriata were studied extensively in the past. Life cycle stages, including the sexual phase, fundamental in diatoms to restore the maximum cell size and avoid miniaturization to death, have been well described for this species. P. multistriata is heterothallic; sexual reproduction is induced when strains of opposite mating type are mixed, and proceeds with cells producing two functionally anisogamous gametes each; however, detailed cytological information for this process is missing. By means of confocal laser scanning microscopy and nuclear staining, we followed the nuclear fate during meiosis, and using time-lapse cinematography, we timed every step of the sexual reproduction process from mate pairing to initial cell hatching. The present paper depicts cytological aspects during gametogenesis in P. multistriata, shedding light on the chloroplast behaviour during sexual reproduction, finely describing the timing of the sexual phases and providing reference data for further studies on the molecular control of this fundamental process.

  14. SEXUAL SIN IN NEW TESTAMENT TIMES BIBLICAL AND CONTEXTUAL PERSPECTIVES IN NIGERIA

    Directory of Open Access Journals (Sweden)

    Akintunde Dorcas Olubanke

    2011-01-01

    Full Text Available Christian ethical standards are breaking down in our nation. Many believe now that individuals have rights, including the right to make their own sexual decisions and that sexual behaviour is an individual's private matter. How then can Christianity or the Church relate to the sexual and marriage problems today? If the bible really has a standard that can safe-guide sexual behaviours, why is sexual sin common even within the Church? Historical-contextual and sociological methods were employed in this paper in order to clearly state the New Testament understanding. The study contextualized Biblical teachings, particularly on sex and marriage to the Africans. Findings revealed that the Bible places sex and sexual activity within the larger context of holiness and faithfulness. In this regard, the Bible presents an honest and often detailed explanation of God's design for sex and its place in human life. The New Testament presents sexual deviance as an intentional rejection of God's authority as Creator and Lord. Invariably, Nigeria is characterized by loose sexual morality, which cannot be divorced from incessant poverty, unemployment and illiteracy, as well as the flood of immigrants to Africa and to Nigeria who brought new forms of family life and new sexual customs. The paper concludes that there is clear evidence that our memories are failing on Jesus’ injunctions in this regard, hence, there is need to draw upon the Christian faith for guidance but African context should not be forgotten

  15. Serum inhibin B in healthy pubertal and adolescent boys

    DEFF Research Database (Denmark)

    Andersson, A M; Juul, A; Petersen, J H;

    1997-01-01

    Inhibin B levels were measured in serum from 400 healthy Danish prepubertal, pubertal, and adolescent males, aged 6-20 yr, in a cross-sectional study using a recently developed immunoassay that is specific for inhibin B, the physiologically important inhibin form in men. In addition, serum levels...

  16. Validity of self-assessment of pubertal maturation

    DEFF Research Database (Denmark)

    Rasmussen, Anna; Wohlfahrt-Veje, Christine; Tefre de Renzy-Martin, Katrine;

    2015-01-01

    BACKGROUND AND OBJECTIVES: Studies of adolescents often use self-assessment of pubertal maturation, the reliability of which has shown conflicting results. We aimed to examine the reliability of child and parent assessments of healthy boys and girls. METHODS: A total of 898 children (418 girls, 480...

  17. Putative effects of endocrine disrupters on pubertal development in the human

    DEFF Research Database (Denmark)

    Teilmann, Grete; Juul, Anders; Skakkebaek, Niels E

    2002-01-01

    Pubertal development is regulated by gonadotrophins and sex hormones. There has been a clear secular trend in the timing of puberty during the last century, puberty becoming earlier. Although improved nutrition is assumed to be the cause, this could partly be associated with exposure to so......-called endocrine disrupters. Precocious puberty has been described in several case reports of accidental exposure to oestrogenic compounds in cosmetic products, food and pharmaceuticals. Local epidemics of premature thelarche have also been suggested to be linked to endocrine disrupters. Children adopted from...

  18. NMR-based metabolomic profiling of overweight adolescents – an elucidation of the effects of inter-/intra-individual differences, gender, pubertal development and physical activity

    DEFF Research Database (Denmark)

    Zheng, Hong; Yde, Christian Clement; Arnberg, Karina;

    2014-01-01

    The plasma and urine metabolome of 192 overweight 12-15-year-old adolescents (BMI of 25.4 ± 2.3 kg/m(2)) were examined in order to elucidate gender, pubertal development measured as Tanner stage, physical activity measured as number of steps taken daily, and intra-/interindividual differences...... in the metabolome are being commenced already in childhood. The relationship between Tanner stage and the metabolome showed that pubertal development stage was positively related to urinary creatinine excretion and negatively related to urinary citrate content. No relations between physical activity...... and the metabolome could be identified. The present study for the first time provides comprehensive information about associations between the metabolome and gender, pubertal development, and physical activity in overweight adolescents, which is an important subject group to approach in the prevention of obesity...

  19. Indirect over-time relations between parenting and adolescents’ sexual behaviors and emotions through global self-esteem

    NARCIS (Netherlands)

    D. van de Bongardt; E. Reitz; M. Deković

    2015-01-01

    The present study examined indirect over-time relations between parenting and adolescent sexuality through global self-esteem. Three waves of online questionnaire data were collected among a community sample of 1,116 Dutch adolescents (M = 13.9 years at baseline). Participants rated the quality of t

  20. Indirect over-time relations between parenting and adolescents’ sexual behaviors and emotions through global self-esteem

    NARCIS (Netherlands)

    van de Bongardt, D.; Reitz, E.; Deković, M.

    2016-01-01

    The present study examined indirect over-time relations between parenting and adolescent sexuality through global self-esteem. Three waves of online questionnaire data were collected among a community sample of 1,116 Dutch adolescents (M = 13.9 years at baseline). Participants rated the quality of

  1. Indirect over-time relations between parenting and adolescents’ sexual behaviors and emotions through global self-esteem

    NARCIS (Netherlands)

    van de Bongardt, D.; Reitz, E.; Deković, M.

    2016-01-01

    The present study examined indirect over-time relations between parenting and adolescent sexuality through global self-esteem. Three waves of online questionnaire data were collected among a community sample of 1,116 Dutch adolescents (M = 13.9 years at baseline). Participants rated the quality of t

  2. 青春期女生接触媒体性知识与其感知及态度关联分析%Relationships between pubertal development and perception of sex media messages among adolescent girls

    Institute of Scientific and Technical Information of China (English)

    余春艳; 楼超华; 王子亮; 廉启国; 左霞云; 钟向阳; 程艳

    2013-01-01

    Objective To examine the influence of the status and timing of pubertal development on the perceptions of sex media messages among adolescent girls, and to provide fundamental basis for targeted sexual health education. Methods An anonymous computer-assisted self interview survey on Pubertal Development and Exposure to Sex Media Messages in Junior School Students in Shanghai was conducted among 1 390 senior and junior high school students by using stratified cluster sampling. Data of 496 girls were included in the final analysis to examine correlations among age, pubertal timing and interests, contents as well as perceptions of sex media messages. Results The more maturing the female students were, the more interested they were in sex media messages (P<0.01), the more likely they were exposed with sex messages except for HIV/STD, and more likely to interpret the messages as approval of adolescent sexual behaviors (P=0. 006). After control of age, girls with earlier pubertal timing were more interested in sex media messages [P = 0.023) and more likely to interpret the messages as approval of adolescent sexual behaviors (P=0.051). Conclusion Girls with earlier pubertal timing are more likely to be attracted by sex media messages and deem media with high approval on adolescent sexual behaviors. More attention should be paid to those girls about their exposure to sex media messages. Positive sexual attitudes and values should be built up to prevent against engaging in early sexual behaviors.%目的 探讨青春发育阶段和青春发动时相对青少年女性接触媒体传达的性知识与性态度的影响,为开展有针对性的性健康教育提供理论依据.方法 在上海市分层整群抽取6所学校的初、高中学生共1 390名,进行匿名电子问卷形式的“上海市中学生青春期健康及接触媒体状况的抽样调查”,选择其中496名处于不同青春发育阶段的青少年女性,分析年龄、青春发动时相与对媒

  3. Adolescent sexual victimization

    DEFF Research Database (Denmark)

    Bramsen, Rikke Holm; Lasgaard, Mathias; Koss, Mary P

    2012-01-01

    at baseline and first time APSV during a 6-month period. Data analysis was a binary logistic regression analysis. Number of sexual partners and displaying sexual risk behaviors significantly predicted subsequent first time peer-on-peer sexual victimization, whereas a history of child sexual abuse, early...

  4. Sexually transmitted infections in pediatric renal transplant recipients: Time to take notice!

    Science.gov (United States)

    Ashoor, Isa; Aviles, Diego; Pasternak, Ryan; Vehaskari, Vesa M

    2015-09-01

    We sought to assess the prevalence of STIs, contraception use, and unintentional pregnancy in our pediatric renal transplant recipients. We performed a retrospective chart review. Forty-nine of 65 patients in our program are currently in the high-risk age window of 13 yr or older (34 men, 15 women; mean age 17 yr old, range 13-23 yr old). There was a disproportionate difference in sexual behavior among the men and women, such that while only 15% of the men reported being sexually active, 53% of the women were sexually active. Among high-risk age-group women, 40% were on hormonal contraception. This increased to 75% in sexually active women. There were no cases of unintentional pregnancy. Thirty percent of sexually active recipients had at least one STI. This was higher among sexually active women (37.5%) compared to men (20%). STIs identified included gonococcal and chlamydial urethritis/cervicitis, Trichomonas vaginitis, HSV-2 genital sores, pelvic inflammatory disease, and HIV. In conclusion, STIs are a realistic public health concern in our pediatric renal transplant recipients. Consensus guidelines on STI screening and reproductive health counseling are needed to address this understudied problem.

  5. Sexual addictions.

    Science.gov (United States)

    Garcia, Frederico Duarte; Thibaut, Florence

    2010-09-01

    The potential adverse consequences, personal distress, shame and guilt presented by patients who suffer from sexual addiction require a more in-depth understanding of the phenomenology and psychobiology of this disorder. A bibliographic review was conducted using MEDLINE and EBSCO databases with the following keywords: "sexual addiction," "hypersexuality," "compulsive sexual behavior," "behavioural addiction," "treatment," and "addiction." Several conceptualizations of excessive nonparaphilic sexual disorder have been proposed based on the models of, respectively, obsessive compulsive disorder, impulse control disorder, out of control excessive sexual disorder, and addictive disorder. Despite the lack of robust scientific data, a number of clinical elements, such as the frequent preoccupation with this type of behavior, the time spent in sexual activities, the continuation of this behavior despite its negative consequences, the repeated and unsuccessful efforts made to reduce the behavior, are in favor of an addictive disorder. In addition there is a high comorbidity between excessive sexual behavior and other addictive behaviors. The phenomenology of excessive nonparaphilic sexual disorder favors its conceptualization as an addictive behavior, rather than an obsessive-compulsive, or an impulse control disorder. Moreover, the criteria that are quite close to those of addictive disorders were recently proposed for the future DSM-V in order to improve the characterization of this condition. Finally, controlled studies are warranted in order to establish clear guidelines for treatment of sexual addiction.

  6. Multidimensional Sexual Perfectionism and Female Sexual Function: A Longitudinal Investigation.

    Science.gov (United States)

    Stoeber, Joachim; Harvey, Laura N

    2016-11-01

    Research on multidimensional sexual perfectionism differentiates four forms: self-oriented, partner-oriented, partner-prescribed, and socially prescribed. Self-oriented sexual perfectionism reflects perfectionistic standards people apply to themselves as sexual partners; partner-oriented sexual perfectionism reflects perfectionistic standards people apply to their sexual partner; partner-prescribed sexual perfectionism reflects people's beliefs that their sexual partner imposes perfectionistic standards on them; and socially prescribed sexual perfectionism reflects people's beliefs that society imposes such standards on them. Previous studies found partner-prescribed and socially prescribed sexual perfectionism to be maladaptive forms of sexual perfectionism associated with a negative sexual self-concept and problematic sexual behaviors, but only examined cross-sectional relationships. The present article presents the first longitudinal study examining whether multidimensional sexual perfectionism predicts changes in sexual self-concept and sexual function over time. A total of 366 women aged 17-69 years completed measures of multidimensional sexual perfectionism, sexual esteem, sexual anxiety, sexual problem self-blame, and sexual function (cross-sectional data). Three to six months later, 164 of the women completed the same measures again (longitudinal data). Across analyses, partner-prescribed sexual perfectionism emerged as the most maladaptive form of sexual perfectionism. In the cross-sectional data, partner-prescribed sexual perfectionism showed positive relationships with sexual anxiety, sexual problem self-blame, and intercourse pain, and negative relationships with sexual esteem, desire, arousal, lubrication, and orgasmic function. In the longitudinal data, partner-prescribed sexual perfectionism predicted increases in sexual anxiety and decreases in sexual esteem, arousal, and lubrication over time. The findings suggest that partner-prescribed sexual

  7. Childhood sexual abuse.

    OpenAIRE

    Evrim Aktepe

    1993-01-01

    Sexual abuse is defined as use of child or adolescent by the adults for satisfying of sexual urges and needs with forcing, threatening or tricking. Sexual abuse can be in the form of sexual abuse without touch, sexual touch, interfemoral intercourse, sexual penetration, and sexual exploitation. The prevalence of sexual abuse is reported as 10-40%. It is seen in female four times more than in males. Abusers are frequently male, only 5-15% of them are female. The abuse by females is usually tow...

  8. Female Pubertal Timing and Problem Behaviour: The Role of Culture

    Science.gov (United States)

    Skoog, Therese; Stattin, Hakan; Ruiselova, Zdena; Ozdemir, Metin

    2013-01-01

    We tested the peer-socialization/contextual-amplification explanation for the link between early female puberty and problem behaviour. We propose that in cultures with high tolerance for adolescent heterosexual involvement, early puberty should be linked with problem behaviour--not in other cultures. We compared girls in two cultures (Slovakia and…

  9. Female Pubertal Timing and Problem Behaviour: The Role of Culture

    Science.gov (United States)

    Skoog, Therese; Stattin, Hakan; Ruiselova, Zdena; Ozdemir, Metin

    2013-01-01

    We tested the peer-socialization/contextual-amplification explanation for the link between early female puberty and problem behaviour. We propose that in cultures with high tolerance for adolescent heterosexual involvement, early puberty should be linked with problem behaviour--not in other cultures. We compared girls in two cultures (Slovakia and…

  10. Getting the timing right: antler growth phenology and sexual selection in a wild red deer population.

    Science.gov (United States)

    Clements, Michelle N; Clutton-Brock, Tim H; Albon, Steve D; Pemberton, Josephine M; Kruuk, Loeske E B

    2010-10-01

    There has been growing interest in the determinants of the annual timing of biological phenomena, or phenology, in wild populations, but research on vertebrate taxa has primarily focused on the phenology of reproduction. We present here analyses of the phenology of the annual growth of a secondary sexual characteristic, antlers in red deer (Cervus elaphus) males. The long-term individual-based data from a wild population of red deer on the Isle of Rum, Scotland allow us to consider ecological factors influencing variation in the phenology of growth of antlers, and the implications of variation in antler growth phenology with respect to the phenotype of antler grown (antler mass) and annual breeding success. The phenology of antler growth was influenced by local environmental conditions: higher population density delayed both the start date (during spring) and the relative end date (in late summer) of antler growth, and warmer temperatures in the September and April prior to growth advanced start and end dates, respectively. Furthermore, there was variation between individuals in this phenotypic plasticity of start date, although not in that of end date of growth. The phenology of antler growth impacted on the morphology of antlers grown, with individuals who started and ended growth earliest having the heaviest antlers. The timing of antler growth phenology was associated with breeding success in the following mating season, independently of the mass of antlers grown: an earlier start of antler growth was associated with siring a higher number of the calves born the following spring. Our results suggest that the phenology of traits that are not directly correlated with offspring survival may also regularly show correlations with fitness.

  11. Prevalence of acne in primary school children and the relationship of acne with pubertal maturation

    OpenAIRE

    Hilal Kaya Erdoğan; İlknur Kıvanç Altunay; Serap Turan

    2014-01-01

    Background and Design: Although acne vulgaris is generally regarded as a disease of adolescence period, it can occur in infancy, early childhood and prepubertal period. Acne may emerge as the first sign of pubertal maturation. In our study, we aimed to determine the acne prevalence in primary school children, then, evaluate the pubertal signs in those children; examine the correlation of the presence and severity of acne with pubertal signs, and finally, revise the concept of prepubertal a...

  12. Effects of programmed physical activity on body composition in post-pubertal schoolchildren.

    Science.gov (United States)

    Farias, Edson Dos Santos; Gonçalves, Ezequiel Moreira; Morcillo, André Moreno; Guerra-Júnior, Gil; Amancio, Olga Maria Silverio

    2015-01-01

    To assess body composition modifications in post-pubertal schoolchildren after practice of a physical activity program during one school year. The sample consisted of 386 students aged between 15 and 17 years and divided into two groups: the study group (SG) comprised 195 students and the control group (CG), 191. The SG was submitted to a physical activity program and the CG attended conventional physical education classes. Body composition was assessed using body mass index (BMI), percentage of body fat (%BF), fat mass (FM), and lean mass (LM). A positive effect of the physical activity program on body composition in the SG (p<0.001) was observed, as well as on the interaction time x group in all the variables analyzed in both genders. A reduction in %BF (mean of differences = -5.58%) and waist circumference (-2.33 cm), as well as an increase in LM (+2.05 kg) were observed in the SG for both genders, whereas the opposite was observed in the CG. The practice of programmed physical activity promotes significant reduction of body fat in post-pubertal schoolchildren. Copyright © 2013 Sociedade Brasileira de Pediatria. Published by Elsevier Editora Ltda. All rights reserved.

  13. A clinic-based youth development program to reduce sexual risk behaviors among adolescent girls: prime time pilot study.

    Science.gov (United States)

    Sieving, Renee E; Bernat, Debra H; Resnick, Michael D; Oliphant, Jennifer; Pettingell, Sandra; Plowman, Shari; Skay, Carol

    2012-07-01

    Multifaceted, sustained efforts are needed to reduce early pregnancy and sexually transmitted diseases among high-risk adolescents. An important area for research is testing youth development interventions offered through clinic settings, where access to high-risk adolescents is plentiful and few efforts have rigorously evaluated a dual approach of building protective factors while addressing risk. This article presents findings from a pilot study of Prime Time, a clinic-based youth development intervention to reduce sexual risk behaviors among girls at risk for early pregnancy. Girls aged 13 to 17 years meeting specified risk criteria were assigned to Prime Time treatment groups. The Prime Time intervention included a combination of case management services and peer leadership groups. Participants completed self-report surveys at baseline, 12 and 18 months following enrollment. At 12 months, the intervention group reported significantly fewer sexual partners than the control group. At 18 months, the intervention group reported significantly more consistent condom use with trends toward more consistent hormonal and dual method use. Dose-response analyses suggested that relatively high levels of exposure to a youth development intervention were needed to change contraceptive use behaviors among adolescents at risk for early pregnancy. Given promising findings, further testing of the Prime Time intervention is warranted.

  14. Behavior, color change and time for sexual inversion in the protogynous grouper (Epinephelus adscensionis.

    Directory of Open Access Journals (Sweden)

    Richard J Kline

    Full Text Available Hermaphroditism, associated with territoriality and dominance behavior, is common in the marine environment. While male sex-specific coloration patterns have been documented in groupers, particularly during the spawning season, few data regarding social structure and the context for these color displays are available. In the present study, we define the social structure and male typical behavior of rock hind (Epinephelus adscensionis in the wild. In addition, we detail the captive conditions and time period necessary to induce the onset of the sex-specific coloration and sexual change. At six oil production platform locations in the Gulf of Mexico, rock hind social group size and typical male rock hind social behavior were documented. We observed a rapid temporary color display in rock hind that could be turned on and off within three seconds and was used for confronting territory intruders and displays of aggression towards females. The male-specific "tuxedo" pattern consists of a bright yellow tail, a body with alternating dark brown and white patches and a dark bar extending from the upper mandible to the operculum. Identification and size ranges of male, female and intersex fish collected from oil platforms were determined in conjunction with gonadal histology. Rock hind social order is haremic with one dominant male defending a territory and a linear dominance hierarchy among individuals. In five captive experiments, the largest remaining female rock hind displayed the male specific color pattern within 32d after dominant male removal from the social group. To our knowledge, this is the first evidence in a grouper species of color patterning used to display territoriality and dominance outside of spawning aggregations. The behavioral paradigm described here is a key advance that will enable mechanistic studies of this complex sex change process.

  15. Behavior, color change and time for sexual inversion in the protogynous grouper (Epinephelus adscensionis).

    Science.gov (United States)

    Kline, Richard J; Khan, Izhar A; Holt, G Joan

    2011-01-01

    Hermaphroditism, associated with territoriality and dominance behavior, is common in the marine environment. While male sex-specific coloration patterns have been documented in groupers, particularly during the spawning season, few data regarding social structure and the context for these color displays are available. In the present study, we define the social structure and male typical behavior of rock hind (Epinephelus adscensionis) in the wild. In addition, we detail the captive conditions and time period necessary to induce the onset of the sex-specific coloration and sexual change. At six oil production platform locations in the Gulf of Mexico, rock hind social group size and typical male rock hind social behavior were documented. We observed a rapid temporary color display in rock hind that could be turned on and off within three seconds and was used for confronting territory intruders and displays of aggression towards females. The male-specific "tuxedo" pattern consists of a bright yellow tail, a body with alternating dark brown and white patches and a dark bar extending from the upper mandible to the operculum. Identification and size ranges of male, female and intersex fish collected from oil platforms were determined in conjunction with gonadal histology. Rock hind social order is haremic with one dominant male defending a territory and a linear dominance hierarchy among individuals. In five captive experiments, the largest remaining female rock hind displayed the male specific color pattern within 32d after dominant male removal from the social group. To our knowledge, this is the first evidence in a grouper species of color patterning used to display territoriality and dominance outside of spawning aggregations. The behavioral paradigm described here is a key advance that will enable mechanistic studies of this complex sex change process.

  16. Behavior, Color Change and Time for Sexual Inversion in the Protogynous Grouper (Epinephelus adscensionis)

    Science.gov (United States)

    Kline, Richard J.; Khan, Izhar A.; Holt, G. Joan

    2011-01-01

    Hermaphroditism, associated with territoriality and dominance behavior, is common in the marine environment. While male sex-specific coloration patterns have been documented in groupers, particularly during the spawning season, few data regarding social structure and the context for these color displays are available. In the present study, we define the social structure and male typical behavior of rock hind (Epinephelus adscensionis) in the wild. In addition, we detail the captive conditions and time period necessary to induce the onset of the sex-specific coloration and sexual change. At six oil production platform locations in the Gulf of Mexico, rock hind social group size and typical male rock hind social behavior were documented. We observed a rapid temporary color display in rock hind that could be turned on and off within three seconds and was used for confronting territory intruders and displays of aggression towards females. The male-specific “tuxedo” pattern consists of a bright yellow tail, a body with alternating dark brown and white patches and a dark bar extending from the upper mandible to the operculum. Identification and size ranges of male, female and intersex fish collected from oil platforms were determined in conjunction with gonadal histology. Rock hind social order is haremic with one dominant male defending a territory and a linear dominance hierarchy among individuals. In five captive experiments, the largest remaining female rock hind displayed the male specific color pattern within 32d after dominant male removal from the social group. To our knowledge, this is the first evidence in a grouper species of color patterning used to display territoriality and dominance outside of spawning aggregations. The behavioral paradigm described here is a key advance that will enable mechanistic studies of this complex sex change process. PMID:21647429

  17. Coming out for a third time: transmen, sexual orientation, and identity.

    Science.gov (United States)

    Rowniak, Stefan; Chesla, Catherine

    2013-04-01

    Female-to-male (FTM) transgender persons are often assumed to have been lesbian in sexual orientation prior to transition and to have maintained a primary attraction for women after transition. However, limited research and anecdotal information from clinicians who work with FTM have indicated that many identify as gay men post-transition. This article described the results of a qualitative study that employed interviews with 17 FTM in order to understand their experience of transition and sexual orientation. Of the 17 participants, seven identified as lesbian prior to transition, three as heterosexual, and seven as bisexual or queer. After transition, 10 identified as gay men and the remaining seven identified as bisexual or queer. Four patterns of sexual behavior emerged from the data and were described and discussed. These patterns were named steadfast, aligned, shifted, and fluid. These findings bring additional options to the belief that there are two distinct types of transgender: a homosexual subtype and a nonhomosexual subtype.

  18. Sexual development in Plasmodium parasites: knowing when it's time to commit.

    Science.gov (United States)

    Josling, Gabrielle A; Llinás, Manuel

    2015-09-01

    Malaria is a devastating infectious disease that is caused by blood-borne apicomplexan parasites of the genus Plasmodium. These pathogens have a complex lifecycle, which includes development in the anopheline mosquito vector and in the liver and red blood cells of mammalian hosts, a process which takes days to weeks, depending on the Plasmodium species. Productive transmission between the mammalian host and the mosquito requires transitioning between asexual and sexual forms of the parasite. Blood- stage parasites replicate cyclically and are mostly asexual, although a small fraction of these convert into male and female sexual forms (gametocytes) in each reproductive cycle. Despite many years of investigation, the molecular processes that elicit sexual differentiation have remained largely unknown. In this Review, we highlight several important recent discoveries that have identified epigenetic factors and specific transcriptional regulators of gametocyte commitment and development, providing crucial insights into this obligate cellular differentiation process.

  19. The Arab Bed Spring? Sexual rights in troubled times across the Middle East and North Africa.

    Science.gov (United States)

    El Feki, Shereen

    2015-11-01

    In recent decades, attitudes in many parts of the Arab region have hardened towards non-conforming sexualities and gender roles, a shift fuelled in part by a rise in Islamic conservatism and exploited by authoritarian regimes. While political cultures have proved slow to change in the wake of the 'Arab Spring', a growing freedom of expression, and increasing activity by civil society, is opening space for discreet challenges to sexual taboos in a number of countries, part of wider debates over human rights and personal liberties in the emerging political and social order.

  20. Cumulative Risk for Early Sexual Initiation among American Indian Youth: A Discrete-Time Survival Analysis

    Science.gov (United States)

    Mitchell, Christina M.; Whitesell, Nancy Rumbaugh; Spicer, Paul; Beals, Janette; Kaufman, Carol E.

    2007-01-01

    Approximately 3 million teens are diagnosed with a sexually transmitted disease (STD) annually; STDs rates for American Indian young adults are among the highest of any racial/ethnic group. An important risk factor for STDs is early initiation of sex. In this study, we examined risk for early initiation with 474 American Indian youth ages 14-18,…

  1. Sexual Dating Aggression across Grades 8 through 12: Timing and Predictors of Onset

    Science.gov (United States)

    Reyes, H. Luz McNaughton; Foshee, Vangie A.

    2013-01-01

    Investigators have identified a number of factors that increase risk for physical and psychological dating abuse perpetration during adolescence, but as yet little is known about the etiology of sexual dating aggression during this critical developmental period. This is an important gap in the literature given that research suggests that patterns…

  2. Prevalence of acne in primary school children and the relationship of acne with pubertal maturation

    Directory of Open Access Journals (Sweden)

    Hilal Kaya Erdoğan

    2014-12-01

    Full Text Available Background and Design: Although acne vulgaris is generally regarded as a disease of adolescence period, it can occur in infancy, early childhood and prepubertal period. Acne may emerge as the first sign of pubertal maturation. In our study, we aimed to determine the acne prevalence in primary school children, then, evaluate the pubertal signs in those children; examine the correlation of the presence and severity of acne with pubertal signs, and finally, revise the concept of prepubertal acne. Materials and Methods: A thousand students from 2 schools in Istanbul were included in the study. Age, gender, and the presence, localization and severity of acne were recorded. Acne severity was evaluated using the Orfanos-Gollnick Acne Grading System while a validated self evaluation form which had been developed by Morris and Udry was used to evaluate pubertal stage. Data were evaluated statistically. Results: Five hundred and thirty-four male and 466 female primary school children, with an age range of 7 to 11, were included in the study. Acne was determined in 11.5% of the students. 20% of girls and 4% of boys had acne. Comparing acne presence and age, the average age was higher in group with acne than those with no acne. The mean age of children with grade 1 acne was lower than those with grade 2 acne. All the students with acne had mid-facial acne. Comparing acne presence and pubertal symptoms, the rate of the presence of acne was higher in pubertal girls. No acne was observed in prepubertal boys. Evaluating acne severity and pubertal signs, the difference between prepubertal and pubertal girls was not significant. Comparing acne and telarche stages, the group without acne had lower telarche rates. Comparing acne and pubertal stages, children with acne had advanced puberty. Conclusion: Our study denotes that acne prevalence is related to pubertal maturation and age; while it does not support the hypothesis that acne is the first sign of pubertal

  3. Time-Course Analysis of the Neuroanatomical Correlates of Sexual Arousal Evoked by Erotic Video Stimuli in Healthy Males

    Energy Technology Data Exchange (ETDEWEB)

    Sundaram, Thirunavukkarasu; Jeong, Gwang Woo; Kim, Tae Hoon; Kim, Gwang Won; Baek, Han Su; Kang, Heoung Keun [Chonnam National University Hospital, Chonnam National University Medical School, Gwangju (Korea, Republic of)

    2010-06-15

    To assess the dynamic activations of the key brain areas associated with the time-course of the sexual arousal evoked by visual sexual stimuli in healthy male subjects. Fourteen right-handed heterosexual male volunteers participated in this study. Alternatively combined rest period and erotic video visual stimulation were used according to the standard block design. In order to illustrate and quantify the spatiotemporal activation patterns of the key brain regions, the activation period was divided into three different stages as the EARLY, MID and LATE stages. For the group result (p < 0.05), when comparing the MID stage with the EARLY stage, a significant increase of the brain activation was observed in the areas that included the inferior frontal gyrus, the supplementary motor area, the hippocampus, the head of the caudate nucleus, the midbrain, the superior occipital gyrus and the fusiform gyrus. At the same time, when comparing the EARLY stage with the MID stage, the putamen, the globus pallidus, the pons, the thalamus, the hypothalamus, the lingual gyrus and the cuneus yielded significantly increased activations. When comparing the LATE stage with the MID stage, all the above mentioned brain regions showed elevated activations except the hippocampus. Our results illustrate the spatiotemporal activation patterns of the key brain regions across the three stages of visual sexual arousal.

  4. Time-course analysis of the neuroanatomical correlates of sexual arousal evoked by erotic video stimuli in healthy males.

    Science.gov (United States)

    Sundaram, Thirunavukkarasu; Jeong, Gwang-Woo; Kim, Tae-Hoon; Kim, Gwang-Won; Baek, Han-Su; Kang, Heoung-Keun

    2010-01-01

    To assess the dynamic activations of the key brain areas associated with the time-course of the sexual arousal evoked by visual sexual stimuli in healthy male subjects. Fourteen right-handed heterosexual male volunteers participated in this study. Alternatively combined rest period and erotic video visual stimulation were used according to the standard block design. In order to illustrate and quantify the spatiotemporal activation patterns of the key brain regions, the activation period was divided into three different stages as the EARLY, MID and LATE stages. For the group result (p < 0.05), when comparing the MID stage with the EARLY stage, a significant increase of the brain activation was observed in the areas that included the inferior frontal gyrus, the supplementary motor area, the hippocampus, the head of the caudate nucleus, the midbrain, the superior occipital gyrus and the fusiform gyrus. At the same time, when comparing the EARLY stage with the MID stage, the putamen, the globus pallidus, the pons, the thalamus, the hypothalamus, the lingual gyrus and the cuneus yielded significantly increased activations. When comparing the LATE stage with the MID stage, all the above mentioned brain regions showed elevated activations except the hippocampus. Our results illustrate the spatiotemporal activation patterns of the key brain regions across the three stages of visual sexual arousal.

  5. Giant pubertal prolactinoma: Complete resolution following short ...

    African Journals Online (AJOL)

    2016-04-06

    Apr 6, 2016 ... disappeared in a short time with cabergoline treatment. Key words: ... stature, and delayed development of his secondary sex characteristics. .... Leong KS, Foy PM, Swift AC, Atkin SL, Hadden DR, MacFarlane IA. CSF.

  6. Longitudinal study of the pattern of pubertal development in Cantonese schoolgirls%广州女孩青春期发育模式的纵向研究

    Institute of Scientific and Technical Information of China (English)

    李燕虹; 马华梅; 陈红珊; 苏喆; 古玉芬; 杜敏联

    2009-01-01

    development (PH2) was 10.67 (9.92-11.38) years. Menarche occurred at (12.35±1.30) years. The age at reaching B2, age at reaching PH2 and age of menarchc were all later than that observed in the cross-section study performed in 2003, Guangzhou, China. Peak height velocity (PHV) was reached at (10.52±1.07) years, 1.00 (0.50-1.50) years after B2 was reached. Interval between " age at onset of breast development" and "age at menarehe" was 2.92 (2.08-3.67 ) years. Duration of pubertal growth ( defined as the time from age at B2 to age at which adult height was attained ) was (4.80±0.85) years. (2) Average final adult bethgt (FAH) was (158.74±5.74) cm. As compared with the cross-section studies held in Guangzhou, China, the FAH in our study was higher than that observed in 1985 but was lower than that observed in 2003. (3) Multiple linear regression analyses showed that the age reaching B2 was an independent factor associated with the age of menarche. (4) Durations of breast stages, interval between B2 and menarcbe and duration of pubertal growth were similar to that reported in the longitudinal studies in the United Kingdom (1969), Senegal (1995-2000), the United States (1986-1996). Conclnsion In healthy Cantonese schoolgirls, the timing of sexual maturation was in a trend of decline in the past 20 years, however, it may have no significant impacts on the tempo of pubertal development and FAH.

  7. Assessment of Sexual Maturation among Boys in Special Schools of Tehran, Iran

    Directory of Open Access Journals (Sweden)

    Asieh Mosallanejad

    2017-01-01

    Full Text Available Background: Due to lack of detailed standards of sexual maturity in individuals with Intellectual, sensory and motor disability in Iran and the importance of timing of onset of puberty in these individuals, a study is necessary. By knowing the onset of puberty, physiologic and behavioral changes can be traced in these people, as well as the potential impact of the puberty on the underlying disease can be considered. The aim of the study was to investigate of sexual maturation among boys of special schools of Tehran. Materials and Methods: Cross-sectional study was performed on children and adolescents male students in special school in Tehran at 2013. A random, multistage sample 0f 895 boy students of special schools was taken from 25 special schools in five districts of Tehran city. In this study, symptoms and stages of puberty were identified. Pubertal stages were assessed by visual inspection and palpation based on the rating scales of Tanner. In addition, demographic data such as age, height, weight were collected. Then the data were analyzed and mean age of onset of puberty was determined. Results: The mean age of onset of puberty in boys (Genitalia stage 2 was 13.12 ± 1.84 years and sexual maturation was completed at 16.57 ± 1.34 years. The average height at the onset of puberty (Genitalia stage 2 was 151.1 ± 9.91 cm and the average weight was 48.47 ± 10.14kg. The mean BMI for puberty onset was 20.89 ± 5.43. Conclusion: In our study, the mean age of puberty onset in boys with disabilities was 13.12 ± 1.84 years. Compared to the data from healthy boys, our findings indicate that the mean age of pubertal onset in boys with disabilities in special school is higher than that of their healthy counterparts.

  8. Semen characteristics in pubertal boys. I. Semen quality after first ejaculation.

    Science.gov (United States)

    Janczewski, Z; Bablok, L

    1985-01-01

    Semen specimens from 134 pubertal boys were examined, and some 274 assays were made. An analysis of the biological quality of semen in relation to the period of time after first ejaculation brings high values of statistical dependence of the volume of semen, its liquefaction, spermatozoal concentration, percentage of morphologically normal forms of spermatozoa, and normal spermatozoal motility on the period of time after first ejaculation. Normal figures for semen volume, semen liquefaction, spermatozoal concentration, and morphology are observed 12-14 months after first ejaculation. The percentage of normally motile spermatozoa becomes standard 21-23 months after first ejaculation. There were changes in semen characteristics from azoospermia through cryptozoospermia, oligozoospermia, and asthenozoospermia to normospermia. Azoospermia dominates until the fifth month after the first ejaculation, oligozoospermia from the sixth to the eleventh month, asthenozoospermia from the twelfth to the twentieth month, and normospermia from the twenty-first month.

  9. Sexual Harassment at Work: A European Experience

    OpenAIRE

    Artan Çela

    2015-01-01

    Unwelcome sexual advances, proposition or pressure for sexual activity, offensive flirtations, leering, whistling, making sexually suggestive gestures, sexual jokes, unwanted sexual looks, unwanted letters, telephone call, or materials of a sexual nature, unwanted physical contact, actual or attempting rape or sexual assault, this and more of this conduct if took place in the workplace would amount to a sexual harassment. The sexual harassment at work has become a serious issue of our time. I...

  10. Prenatal androgen excess programs metabolic derangements in pubertal female rats.

    Science.gov (United States)

    Yan, Xiaonan; Dai, Xiaonan; Wang, Jing; Zhao, Nannan; Cui, Yugui; Liu, Jiayin

    2013-04-01

    Owing to the heterogeneity in the clinical symptoms of polycystic ovary syndrome (PCOS), the early pathophysiological mechanisms of PCOS remain unclear. Clinical, experimental, and genetic evidence supports an interaction between genetic susceptibility and the influence of maternal environment in the pathogenesis of PCOS. To determine whether prenatal androgen exposure induced PCOS-related metabolic derangements during pubertal development, we administrated 5α-dihydrotestosterone (DHT) in pregnant rats and observed their female offspring from postnatal 4 to 8 weeks. The prenatally androgenized (PNA) rats exhibited more numerous total follicles, cystic follicles, and atretic follicles than the controls. Fasting glucose, insulin, leptin levels, and homeostatic model assessment for insulin resistance were elevated in the PNA rats at the age of 5-8 weeks. Following intraperitoneal glucose tolerance tests, glucose and insulin levels did not differ between two groups; however, the PNA rats showed significantly higher 30- and 60-min glucose levels than the controls after insulin stimulation during 5-8 weeks. In addition, prenatal DHT treatment significantly decreased insulin-stimulated phosphorylation of AKT in the skeletal muscles of 6-week-old PNA rats. The abundance of IR substrate 1 (IRS1) and IRS2 was decreased in the skeletal muscles and liver after stimulation with insulin in the PNA group, whereas phosphorylation of insulin-signaling proteins was unaltered in the adipose tissue. These findings validate the contribution of prenatal androgen excess to metabolic derangements in pubertal female rats, and the impaired insulin signaling through IRS and AKT may result in the peripheral insulin resistance during pubertal development.

  11. Physical provocation of pubertal anabolic androgenic steroid exposed male rats elicits aggression towards females.

    Science.gov (United States)

    Cunningham, Rebecca L; McGinnis, Marilyn Y

    2006-09-01

    Human studies suggest that anabolic androgenic steroid (AAS) users are aggressive towards women. This study used a rat model to evaluate whether AAS potentiated aggression towards females and the conditions under which this occurs. Gonadally intact pubertal male rats received one of the following AAS treatments (5 mg/kg s.c. 5 days/week for nine weeks): testosterone (T), stanozolol (S), testosterone + stanozolol (T + S), or vehicle control. Each rat was tested with 3 conspecific stimuli: ovariectomized females (OVX), estrogen only females (E), and estrogen + progesterone females (E + P). The response to physical provocation was tested under three conditions: without physical provocation, provocation of the experimental male, and provocation of the conspecific female. Provocation was a mild tail pinch. Both aggressive and sexual behaviors were measured during each test. In the absence of physical provocation, AAS males were not aggressive towards females. However, provocation significantly increased aggression in males treated with testosterone but only towards OVX females. In the presence of E or E + P females, all animals displayed sex behavior, not aggression. Thus, factors such as the nature of the AAS and the hormonal status of the females are important in determining whether male rats will be aggressive towards females. However, the most salient factor determining aggression towards females is the presence of provocation in combination with high levels of testosterone.

  12. Gender and ethnic differences in the timing of first sexual intercourse.

    Science.gov (United States)

    Upchurch, D M; Levy-Storms, L; Sucoff, C A; Aneshensel, C S

    1998-01-01

    This study estimated the effects of gender and ethnic differences on the risk of first intercourse (FI) among a population-based sample of Los Angeles County youths aged 12-17 years. Longitudinal surveys were conducted during 1992-94 and 1994-95. The sample was of the multistage, stratified probability type. The sample included 877 interviewed adolescents in the 1st round and 675 in the 2nd. Almost 50% of respondents were Hispanic. 58% lived with both parents. The median age of intercourse was 16.9 years; 16.6 years for males and 17.2 years for females. Blacks reported the youngest age of FI at 15.8 years. Asian adolescents had the oldest age of FI at 17.6 years. The same pattern occurred for median age at FI. Age at FI did not vary as much by ethnicity for females. White and Black females had younger ages of FI than Asian females. Black males had significantly higher rates of FI than White females. Asian males were less likely than White females to be sexually experienced. Hispanic and Asian females had significantly lower rates of sexual activity than White females. Family structure was significantly associated with risk of sexual activity. With controls for differences in family background, rates of FI differed significantly by ethnicity among males, but not females. Teenagers living with a single parent or step family had significantly higher rates of transition to first sex than those living with both parents. Family structure may measure the effects of family disruption, rather than parenting behaviors. Findings demonstrate that ethnicity and gender are key factors that predict adolescents' risk of becoming sexually active.

  13. Sexuality and the law.

    Science.gov (United States)

    Portelli, C J

    1998-01-01

    Federal, state, and local laws in the US now govern almost every aspect of sexuality. This includes sexuality at the workplace, sexuality education, adolescent sexuality, access to sexuality information and sexually explicit materials, sexual orientation, and sexually transmitted disease(STD)/HIV transmission. Almost 33% of the US Supreme Court's docket this past term concerned sexuality issues. In contrast to 50 years ago, when sexuality law was confined to the criminal arena, contemporary "sex crimes" primarily relate to nonconsensual and exploitative behaviors. It is time for lawmakers, judges, lawyers, policy analysts, lobbyists, and advocates to realize they cannot legislate or litigate how, when, or why people fall in love. Rather, the role of the law should be to create and preserve models of justice and equality that seek to preserve one's individual rights to privacy and freedom to choose in matters related to one's sexuality. This includes free access to age-appropriate sexuality information, the right to marriage and children regardless of sexual orientation, comprehensive sexuality education that encompasses information about avoiding unwanted pregnancies and HIV/STDs, access to contraception and abortion, protection from sexually abusive or exploitative relationships, and access to sexual health care.

  14. The reciprocal relationship between sexual victimization and sexual assertiveness.

    Science.gov (United States)

    Livingston, Jennifer A; Testa, Maria; VanZile-Tamsen, Carol

    2007-03-01

    Low sexual assertiveness has been proposed as a possible mechanism through which sexual revictimization occurs, yet evidence for this has been mixed. In this study, prospective path analysis was used to examine the relationship between sexual refusal assertiveness and sexual victimization over time among a community sample of women. Results provide support for a reciprocal relationship, with historical victimization predicting low sexual assertiveness and low sexual assertiveness predicting subsequent victimization. The effect of recent sexual victimization on subsequent sexual assertiveness also was replicated prospectively. These findings suggest that strengthening sexual assertiveness may help reduce vulnerability to future victimization.

  15. "Testing is Healthy" TimePlay campaign: Evaluation of sexual health promotion gamification intervention targeting young adults.

    Science.gov (United States)

    Zhang, Qinya; Huhn, Kim J; Tan, Andy; Douglas, Rachel E; Li, Helen Guiyun; Murti, Michelle; Lee, Victoria

    2017-04-20

    The objectives of the study were to 1) describe the implementation of the "Testing is Healthy" campaign in four locations in British Columbia (BC) and 2) report process evaluation indicators for the campaign. Young adults ages 20-29 years, the age group with the highest reported rates of chlamydia and gonorrhea in BC. Movie theatres located in Langley, Burnaby, Coquitlam and Surrey, which are communities served by the Fraser Health Authority (FHA) in BC. The FHA launched the campaign in 2014 and 2015 to bring down the prevalence of sexually transmitted infections (STIs) and HIV in the region. The campaign used the Cineplex TimePlay platform to engage moviegoers in answering STI/HIV-related questions, and to connect them to a clinic finder on the BC Centre for Disease Control Sex Smart Resource (SSR) website. TimePlay includes elements of gaming, is technology-based, and has been a successful advertisement platform for consumer products and services. However, this is the first time it has been used for sexual health promotion. The campaign was evaluated for 1) reach, based on theatre attendance and TimePlay participation, and 2) the effectiveness of connecting people to sexual health information using SSR web analytics. In total, the campaign received 548 410 views and 77 149 plays. SSR web analytics showed a significant increase in unique page views of the Clinic Finder page between the first and the second campaign. The campaign reached a large population at a low cost and was correlated with spikes in the unique page views for the Clinic Finder page.

  16. Granular Vulvovaginitis Syndrome in Nelore pubertal and post pubertal replacement heifers under tropical conditions: role of Mycoplasma spp., Ureaplasma diversum and BHV-1.

    Science.gov (United States)

    Gambarini, M L; Kunz, T L; Oliveira Filho, B D; Porto, R N G; Oliveira, C M G; Brito, W M E D; Viu, M A O

    2009-10-01

    In order to determine the role of Mycoplasma spp, Ureaplasma diversum and BHV-1 as causal agents of Granular Vulvovaginitis Syndrome in Nelore heifers raised under tropical conditions and based on the hypothesis that stressful conditions during puberty or breeding season would be a determinant factor for the infection, 340 heifers not vaccinated against BHV-1 were divided in Post-pubertal, in the beginning of the first breeding season, and Pubertal heifers. The vaginal lesion score (VLS) Grade 1 to 4 was giving according to lesion area and severity. Vaginal mucus was used to isolate Mycoplasma spp., Ureaplasma diversum and BHV-1. The predominant VLS was 2. No sample was positive for BHV-1; 48% were positive for Mycoplasma spp., Ureaplasma diversum, or both, with predominance of Ureaplasma diversum. Serum neutralization for BHV-1 showed more positive animals in pubertal group (23%); 3 of the paired sera demonstrated seroconversion. These data indicated that post-pubertal and pubertal Nelore heifers raised under extensive conditions are more susceptible to Mycoplasma spp. and Ureaplasma diversum. The hypothesis that the stress of pubertal period could lead to an acute vaginal infection by HBV-1 was not proofed.

  17. Indian concepts on sexuality.

    Science.gov (United States)

    Chakraborty, Kaustav; Thakurata, Rajarshi Guha

    2013-01-01

    India is a vast country depicting wide social, cultural and sexual variations. Indian concept of sexuality has evolved over time and has been immensely influenced by various rulers and religions. Indian sexuality is manifested in our attire, behavior, recreation, literature, sculptures, scriptures, religion and sports. It has influenced the way we perceive our health, disease and device remedies for the same. In modern era, with rapid globalization the unique Indian sexuality is getting diffused. The time has come to rediscover ourselves in terms of sexuality to attain individual freedom and to reinvest our energy to social issues related to sexuality.

  18. Pubertal development in elite juvenile gymnasts. Effects of physical training.

    Science.gov (United States)

    Lindholm, C; Hagenfeldt, K; Ringertz, B M

    1994-03-01

    Twenty-two female teenagers engaged in elite gymnast training were prospectively studied during a five-year period and their pubertal development was recorded. Height and weight, as well as stage of development according to Tanner, were registered every six months. FSH, LH, TSH and prolactin were measured in girls who had not yet had their first menstrual period. Twenty-two healthy school girls in the same age group who were not actively engaged in physical exercise served as a control group. Pubertal development was completed during the observation period in all the gymnasts but one, who had primary amenorrhea at the age of eighteen. As a group, the gymnasts had a significantly delayed age of menarche compared to the control group and to normal Swedish girls. They also had significantly less body fat and were shorter and lighter than the control group. They grew much more slowly and did not have the distinct growth spurt seen in the controls. The final height of six of the gymnasts was less than the expected height. The frequency of injuries was high in the gymnasts, which might be a result of hard training combined with late menarche and low body fat.

  19. Physical Stress may Result in Growth Suppression and Pubertal Delay in Working Boys

    Directory of Open Access Journals (Sweden)

    Muhammad Irfan

    2012-01-01

    Full Text Available Child labour is an immense problem in Pakistan. As labour boys are put under persistent/severe physical stress, we hypothesised, that it may result in higher levels of cortisol and exhaust glycogen, fats and protein. Depletion of fats may result in lower body weight, and insufficient leptin concentrations could excite gonadotropic releasing hormone (GnRH at normal time of puberty in working boys. Moreover, lower testosterone levels in working boys, due to delayed puberty, may result in suppression of somatotropic axis. Short/weak stature and failure of onset of puberty may cause poor performance, inferiority complex and psychological disorders. Therefore, the present study is designed to find out the timing of onset of puberty in working boys. The study will include 10–18 years of working boys as case and non-working boys of the same age group as control. Working boys will be labour boys, while the control group will not be involved in physical work. A questionnaire will be used to record socioeconomic status, major diseases, nutritional status, type and duration of work and family history of puberty, growth and obesity of subjects. Boys with familial history of pubertal delay, obesity, malnutrition, mental disorders, haematological diseases and severe/chronic diseases will be excluded. The intensity of physical working stress will be determined by a grading scale. The anthropometric data including height, weight, body mass index (BMI, bone age and tests of adiposity will be collected from subjects. The stages of pubertal onset will be determined by Tanner staging. Serum concentrations of hormones of growth, thyroid, adrenal, brain–gut and gonadal axis will be determined in non-working and working boys. Physical and hormonal tests of the working boys and the comparison with non-working boys are sufficient to test the idea

  20. Physical Stress May Result in Growth Suppression and Pubertal Delay in Working Boys

    Directory of Open Access Journals (Sweden)

    Mazhar Qayyum

    2011-01-01

    Full Text Available Child labor is an immense problem of Pakistan. As labor boys stay under persistent/severe physical stress, we hypothesized, that it may result in higher levels of cortisol and exhaust glycogen, fats and proteins. Depletion of fats may result in lower body weight, and insufficient leptin concentrations to excite gonadotropic releasing hormone (GnRH at the normal time of puberty in working boys. Moreover, lower testosterone levels in working boys, due to delayed puberty, may result in suppression of somatotropic axis. The Short/weak stature and failure of the onset of puberty may cause poor performance, the inferiority complex and psychological disorders. Therefore, present study is designed to find out timing of onset of the puberty in working boys. The study will include 10-18 years of working boys as a case and non-working boys of same age groups as control. Working boys will be labor boys while the control group will not be involved in physical work. A questionnaire will be used to record socioeconomic status, major diseases, nutritional status, type, and duration of work and family history of puberty, growth and obesity of subjects. Boys with familial history of pubertal delay, obesity, malnutrition, mental disorders, hematological diseases and severe/chronic diseases will be excluded. The intensity of physical working stress will be determined by a grading scale. The anthropometric data including height, weight, body mass index (BMI, bone age, tests of adiposity will be collected from subjects. The stages of pubertal onset will be determined by Tanner staging. Serum concentrations of hormones of growth, thyroid, adrenal, brain-gut and gonadal axis will be determined in nonworking and working boys. Physical and hormonal tests of the working boys and comparison with non-working boys are sufficient to test the idea.

  1. Sexual anxiety and eroticism predict the development of sexual problems in youth with a history of sexual abuse.

    Science.gov (United States)

    Simon, Valerie A; Feiring, Candice

    2008-05-01

    Youth with confirmed histories of sexual abuse (N = 118) were followed longitudinally to examine associations between their initial sexual reactions to abuse and subsequent sexual functioning. Participants were interviewed at abuse discovery (ages 8 through 15) and again 1 and 6 years later. Eroticism and sexual anxiety emerged as distinct indices of abuse-specific sexual reactions and predicted subsequent sexual functioning. Eroticism was associated with indicators of heightened sexuality, including more sexual risk behavior and views of sexual intimacy focused on partners' needs. Sexual anxiety was associated with indicators of diminished sexuality, including few sexual partners and avoidant views of sexual intimacy. Age at abuse discovery moderated some associations, suggesting that the timing of abuse-specific reactions affects trajectories of sexual development. Findings point to the need for a developmental approach to understanding how abuse-specific sexual reactions disrupt sexual development and the need for early interventions promoting healthy sexual development.

  2. EFFECT OF GnRH AND PHOSPHORUS IN DELAYED PUBERTAL SURTI BUFFALO HEIFERS

    Directory of Open Access Journals (Sweden)

    H.B. Dhamsaniya

    2016-06-01

    Full Text Available The study was conducted on eighteen delayed pubertal Surti buffalo heifers, divided into three equal groups (6 in each to evaluate the efficacy of GnRH alone and in combination of phosphorus. The buffalo heifers in Group-I and Group-II were treated with Buserelin acetate (5 ml, IM. Buffalo heifers in Group-II also received additional injection of Toldimphos sodium (10 ml, IM at 3 day interval for 4 times, while buffalo heifers in Group-III served as control. The percentage of induced estrus was highest (83.33% in each treated groups as compared to control group (50%. The mean estrus induction intervals were significantly (P<0.05 shorter in Group-I (20.20 ± 2.18 days and Group-II (18.80 ± 2.32 days as compared to control group (30.24 ± 0.81 days. The conception rate at induced estrus was highest in Group-II (50% followed by Group-I (33.33%. The plasma progesterone levels being significantly lowest on the day of estrus (less than 0.5 ng/ml as compared to pre-treatment days in all groups. The mean total protein and triglycerides levels were differed significantly between the groups on the day of estrus and being significantly higher in Group-II as compared to Group-I and III on that day. A significantly higher level of cholesterol in both treatment groups as compared to the control group during different intervals and also being higher on the day of estrus as compared to pre-treatment days. The mean plasma glucose levels were differed nonsignificantly between and within the treatment and control groups. It is concluded that estrus can be successfully induced in delayed pubertal heifers with the use of GnRH alone and in combination with phosphorus.

  3. Estrus induction and fertility response in delayed pubertal Kankrej heifers treated with norgestomet ear implant

    Directory of Open Access Journals (Sweden)

    C. F. Chaudhari

    Full Text Available Aim: The study was undertaken to find out the estrus induction and fertility response in delayed pubertal Kankrej heifers treated with norgestomet ear implant. Materials and methods: Total eighteen anoestrus Kankrej heifers of delayed puberty weighed above 250 kg and attained between 30 to 36 months of age were selected and divided in to three groups of six animals each at random to conduct the experiment. Animals in group 1 were implanted Crestar ear implant for 9 days. In addition to this, group 2 received 500 IU of PMSG on the day of implant removal. In group 3, treatment protocol remained same as in group 2, but Inj. Receptal @ 2 ml was given additionally at the time of breeding. Results: All the animals exhibited estrus with average duration of 25.41+ 0.94, 21.95+ 0.20 and 22.68 + 1.46 hours between implant withdrawal and estrus induction in group 1, 2 and 3, respectively. The duration of estrus was significantly (P<0.05 longer (25.61+ 2.95 hours in group 2, followed by group 1 (18.88 + 1.45 hours and group 3 (13.48 + 1.92 hours. The pregnancy rate at induced estrus was 33.33 percent in group 2. In group 1 and group 3 none of the heifers found pregnant at induced estrus. The overall conception rate was maximum in group 2 (66.67 percent followed by group 3 (50 percent and group 1 (33.33 percent after the 3rd service. Conclusion: Although the conception rate at induced estrus was lower, norgestomet ear implant could be utilized to induced estrus in delayed pubertal cow heifers. [Vet. World 2012; 5(8.000: 453-458

  4. Pubertal Shifts in Adrenal Responsiveness to Stress and Adrenocorticotropic Hormone in Male Rats

    Science.gov (United States)

    Romeo, Russell D.; Minhas, Sumeet; Svirsky, Sarah E.; Hall, Baila S.; Savenkova, Marina; Karatsoreos, Ilia N.

    2014-01-01

    Summary Studies have indicated significant pubertal-related differences in hormonal stress reactivity. We report here that prepubertal (30d) male rats display a more protracted stress-induced corticosterone response than adults (70d), despite showing relatively similar levels of adrenocorticotropic hormone (ACTH). Additionally, we show that adrenal expression of the ACTH receptor, melanocortin 2 receptor (Mc2r), is higher in prepubertal compared to adult animals, and that expression of melanocortin receptor accessory protein (Mrap), a molecule that chaperones MC2R to the cell surface, is greater in prepubertal males following stress. Given that these data suggest a pubertal shift in adrenal sensitivity to ACTH, we directly tested this possibility by injecting prepubertal and adult males with 6.25 or 9.375 μg/kg of exogenous rat ACTH and measured their hormone levels 30 and 60 min post-injection. As these doses resulted in different circulating levels of ACTH at these two ages, we performed regression analyses to assess the relationship between circulating ACTH and corticosterone concentrations. We found no difference between the ages in the correlation between ACTH and corticosterone levels at the 30 min time point. However, 60 min following the ACTH injection, we found prepubertal rats had significantly higher corticosterone concentrations at lower levels of ACTH compared to adults. These data suggest that prolonged exposure to ACTH leads to greater corticosterone responsiveness prior to puberty, and indicate that changes in adrenal sensitivity to ACTH may, in part, contribute to the protracted hormonal stress response in prepubertal rats. PMID:24636511

  5. Effect of stress hormone antagonists on ovarian follicular development in pre-pubertal rat

    Directory of Open Access Journals (Sweden)

    Kalid Hamood Abdullah

    2012-08-01

    Full Text Available Effect of stress on pre-pubertal ovarian follicular development was studied. Fifteen day old female rats were administered under stress (exposed to maternal separation; 6 hours/day from post-natal day 15 to 21 for 7 days, and appropriate controls were maintained. The time of exposure was randomly changed every day during light phase (7AM to 7 PM of the day to avoid habituation. There was a significant decrease in serum estrogen levels on post-natal day 21 in stress group rats compared to controls indicating stress response in these rats. However, mean number of healthy follicles in all categories of follicles were significantly lower in stressed rats compared to controls. Concomitant with these changes, mean number of atreitic follicles showed an increase over control values in stressed rats. In contrast administration of Naltrexone (5μg NTX/rat/day, Mifepristone (1 μg MP/rat/day, FSH (10 IU FSH/rat/day with stressed the significant increases in the relative weight of ovary, uterus, fallopian tube, body weight and the mean number of healthy follicles in the ovary compared to the controls. In the ovary treatment of stressed did not affect primordial follicles. Primordial follicles were reduced in number significantly in the ovary of controls and treated groups when compared with the initial controls whereas there was no significant variation among the controls and the treated groups. The results indicate that stress dose not interfere with the progress of pre-pubertal follicular development. However, it causes increased loss of follicles by atretia.

  6. Coping and coping effectiveness in relation to a competitive sport event: pubertal status, chronological age, and gender among adolescent athletes.

    Science.gov (United States)

    Nicholls, Adam; Polman, Remco; Morley, David; Taylor, Natalie J

    2009-06-01

    An aim of this paper was to discover whether athletes of different pubertal status, chronological age, and gender reported distinct coping strategies in response to stress during a competitive event in their sport. A secondary aim was to examine pubertal status group, chronological age, and gender differences in coping effectiveness. Participants were adolescent athletes (n = 527), classified as beginning-pubertal (n = 59), midpubertal (n = 189), advanced-pubertal (n = 237), and postpubertal (n = 22). Findings revealed that there were small, but significant differences in how athletes of different pubertal status and chronological age coped. There were also significant differences between how athletes of different pubertal status perceived the effectiveness of their coping strategies. Interestingly, our results suggested that the relationship between pubertal status and coping and coping effectiveness is different from the relationship between chronological age and coping and coping effectiveness.

  7. Pubertal maturation and sex steroids are related to alcohol use in adolescents.

    Science.gov (United States)

    de Water, Erik; Braams, Barbara R; Crone, Eveline A; Peper, Jiska S

    2013-02-01

    Adolescents often show risk-taking behavior, including experimentation with alcohol. Previous studies have shown that advanced pubertal maturation is related to increased alcohol use in adolescents, even when controlling for age. Little is known about the underlying mechanisms of this relation between pubertal maturation and alcohol use. The goal of the present study was twofold. In Experiment 1, we investigated whether advanced pubertal maturation is associated with higher levels of alcohol use, when controlling for age. To this end, questionnaires on pubertal development and alcohol use were administered to a large sample of 797 Dutch adolescents (405 boys) aged 11-16 years. In Experiment 2, we explored whether sex steroids contribute to this relation between pubertal maturation and alcohol use by examining the association between salivary sex steroid levels and alcohol use in 168 adolescents (86 boys). It was found that, when controlling for age, advanced pubertal maturation is related to increased alcohol use in adolescent boys and girls. Controlling for age, higher testosterone and estradiol levels correlated with the onset of alcohol use in boys. In addition, higher estradiol levels were associated with a larger quantity of alcohol use in boys. Correlations between sex steroids and alcohol use were not significant in girls. These findings show that advanced pubertal maturation is related to advanced alcohol use, and that higher sex steroid levels could be one of the underlying mechanisms of this relation in boys. Sex steroids might promote alcohol use by stimulating brain regions implicated in reward processing.

  8. [Human papilloma virus and Chlamydia trachomatis by number of sexual partners and time of sexual activity on university students in the Region of La Araucanía, Chile].

    Science.gov (United States)

    Melo, Angélica; Lagos, Nicole; Montenegro, Sonia; Orellana, Juan José; Vásquez, Ana María; Moreno, Sergio; Liempi, Sandra; Guzmán, Pablo; Fonseca-Salamanca, Flery

    2016-06-01

    Human papilloma virus (HPV) and Chlamydia trachomatis are the most prevalent sexually transmitted infections (STIs), among teenagers and young people, with risk factors: active sex life and multiple partners. Chlamydia trachomatis infection may favor HPV infection and this, the development of cervical cancer. Both infections can lead to consequences on sexual and reproductive health. To determine frequency of HPV and C. trachomatis in asymptomatic university women less than 25 years, associating them with number of sexual partners (n°SxP) and time of sexual activity (TSxA). Material andMethods: 151 cervical samples for HPV and C. trachomatis, were processed by conventional and in real time reaction polymerase chain. HPV 21, 8%, C. trachomatis 11, 2% and co-infection (HPV/C.trachomatis), 4.6%. Aimong HPV +, 80, 6% showed high risk HPV. The n°SxP was strongly associated with HPV. Aimong young coinfected HPV/C. trachomatis, 71.4% had 3 or more PSx. Chlamydia trachomatis was more frequent (64,7%) that HPV within range of 3-5 years according to the TSxA, Discussion: A high prevalence of HPV and C. trachomatis was observed. Young women with coinfection HPV/C. trachomatis could be a high-risk group need to monitor their infections. It suggests the implementation of university programs in education, counseling and prevention in sexual health.

  9. Don't Forget, Thursday Is Test[icle] Time! The Use of Humour in Sexuality Education

    Science.gov (United States)

    Allen, Louisa

    2014-01-01

    Sexuality and humour share a fraught relationship at school, so that how humour might be productively employed in sexuality education constitutes a "risky" consideration. This paper explores the role of humour in sexuality education as observed in a Year 9 New Zealand health class. Adding to existing literature emphasising students' use…

  10. Don't Forget, Thursday Is Test[icle] Time! The Use of Humour in Sexuality Education

    Science.gov (United States)

    Allen, Louisa

    2014-01-01

    Sexuality and humour share a fraught relationship at school, so that how humour might be productively employed in sexuality education constitutes a "risky" consideration. This paper explores the role of humour in sexuality education as observed in a Year 9 New Zealand health class. Adding to existing literature emphasising students' use…

  11. White willow sexual regeneration capacity under estuarine conditions in times of climate change

    Science.gov (United States)

    Markus-Michalczyk, Heike; Hanelt, Dieter; Denstorf, Julian; Jensen, Kai

    2016-10-01

    Tidal wetlands provide both habitats for coastal populations and wildlife, and ecosystem services for human welfare. Building with nature regarding cost-effective coastal protection is of increasing interest. Much research has been carried out on plant reproduction capacities in mangroves and salt marshes, but less is known on this issue in tidal freshwater wetlands. Willows are being successfully used for bank stabilization in riverine habitats, however, today white willow softwood forests in tidal wetlands are highly fragmented, and restoration is required e.g. by the European Habitats Directive. Recently, tolerance to increasing salinity and tidal flooding was found for vegetative propagules of floodplain willows. However, the establishment of autochthonous sexual recruits is necessary to conserve the genetic diversity of local populations, and thus may be preferable in restoration. The germination and early seedling establishment of Salix alba (white willow) was experimentally studied under simulated estuarine conditions. The species tolerance to increasing salinity (0, 0.5, 1, 1.5, and 2) was tested in a climate chamber, and its tolerance to flooding at different tidal treatments (control, spring tide, daily tide 15 min and 2 h flooding) in the greenhouse. Germination was neither affected by increasing salinity nor by tidal flooding. Salix seedlings established up to salinity 1.5, but cotyledon performance and radicle growth was largely reduced at salinity 2. Under tidal flooding, seedling growth was similar in all treatments. However, in the treatments with daily tides seedling anchorage in the substrate took more than two weeks, and fewer seedlings reached a suitable length to approach the high water line. We assess S. alba sexual regeneration under estuarine conditions as generally possible. Further studies are needed on the effects of sedimentation-erosion processes on willow establishment in the field, especially on feedbacks between Salix survival and

  12. Acceleration of pubertal development following pituitary radiotherapy for Cushing's disease

    Energy Technology Data Exchange (ETDEWEB)

    Nicholl, R.M.; Kirk, J.M.W.; Grossman, A.B.; Plowman, P.N.; Besser, G.M.; Savage, M.O. (Saint Bartholomew' s Hospital, London (United Kingdom))

    1993-01-01

    A 7-year-old boy with pituitary dependent Cushing's disease was treated with pituitary irradiation following unsuccessful microadenomectomy. This led to normalization of the hypercortisolaemia, but was followed by GH deficiency. Two years after radiotherapy he had the onset of pubertal development with testicular enlargement to 8 ml bilaterally. Pubertal regression was induced using the long-acting GnRH analogue goserelin. Acceleration of skeletal maturation was also arrested, resulting in improvement of final height prediction. Irradiation directly to the hypothalamo-pituitary region, as well as whole brain irradiation, may thus be associated with accelerated pubertal development. (author).

  13. Pubertal bisphenol A exposure alters murine mammary stem cell function leading to early neoplasia in regenerated glands.

    Science.gov (United States)

    Wang, Danhan; Gao, Hui; Bandyopadhyay, Abhik; Wu, Anqi; Yeh, I-Tien; Chen, Yidong; Zou, Yi; Huang, Changjiang; Walter, Christi A; Dong, Qiaoxiang; Sun, Lu-Zhe

    2014-04-01

    Perinatal exposure to bisphenol A (BPA) has been shown to cause aberrant mammary gland morphogenesis and mammary neoplastic transformation. Yet, the underlying mechanism is poorly understood. We tested the hypothesis that mammary glands exposed to BPA during a susceptible window may lead to its susceptibility to tumorigenesis through a stem cell-mediated mechanism. We exposed 21-day-old Balb/c mice to BPA by gavage (25 μg/kg/d) during puberty for 3 weeks, and a subset of animals were further challenged with one oral dose (30 mg/kg) of 7,12-dimethylbenz(a)anthracene (DMBA) at 2 months of age. Primary mammary cells were isolated at 6 weeks, and 2 and 4 months of age for murine mammary stem cell (MaSC) quantification and function analysis. Pubertal exposure to the low-dose BPA increased lateral branches and hyperplasia in adult mammary glands and caused an acute increase of MaSC in 6-week-old glands and a delayed increase of luminal progenitors in 4-month-old adult gland. Most importantly, pubertal BPA exposure altered the function of MaSC from different age groups, causing early neoplastic lesions in their regenerated glands similar to those induced by DMBA exposure, which indicates that MaSCs are susceptible to BPA-induced transformation. Deep sequencing analysis on MaSC-enriched mammospheres identified a set of aberrantly expressed genes associated with early neoplastic lesions in patients with human breast cancer. Thus, our study for the first time shows that pubertal BPA exposure altered MaSC gene expression and function such that they induced early neoplastic transformation.

  14. Abused Sexuality- Experience of Sexuality Post Experiences of Sexual Abuse

    OpenAIRE

    Sunanda Jalote

    2016-01-01

    Sexual abuse has been happening from times immemorial and is that brutal aspect of society which also talk about spirituality, peace and harmony in the same breath. Youth gets irrevocably scarred by such childhood traumas which linger on in their adult life too. In the present study, an effort was made to study and understand how heterosexual and queer youth in contemporary middle class in Delhi explore the relationship sexual abuse survivors have with their own sexuality and how their negoti...

  15. Abused Sexuality- Experience of Sexuality Post Experiences of Sexual Abuse

    OpenAIRE

    Sunanda Jalote

    2016-01-01

    Sexual abuse has been happening from times immemorial and is that brutal aspect of society which also talk about spirituality, peace and harmony in the same breath. Youth gets irrevocably scarred by such childhood traumas which linger on in their adult life too. In the present study, an effort was made to study and understand how heterosexual and queer youth in contemporary middle class in Delhi explore the relationship sexual abuse survivors have with their own sexuality and how their negoti...

  16. A pre-pubertal girl with giant juvenile fibroadenoma: A rare case report

    Directory of Open Access Journals (Sweden)

    Kumar Gaurav

    2015-01-01

    Conclusion: Through this case we want to emphasize that these giant benign neoplasms should be suspected in any pre-pubertal girl with breast lump and should always be treated with breast conserving surgery.

  17. Insulin resistance in obese pre-pubertal children: Relation to body ...

    African Journals Online (AJOL)

    Heba Elsedfy

    2014-04-16

    Apr 16, 2014 ... sensitivity indices and investigate its relationship with abdominal fat distribution by Dual energy ... associated with negative metabolic predictors in pubertal ..... metabolic determinants of nonalcoholic fatty liver disease in.

  18. Maternal pre-pregnancy body mass index and pubertal development among sons

    DEFF Research Database (Denmark)

    Hounsgaard, M L; Håkonsen, L B; Vested, A

    2013-01-01

    Maternal overweight and obesity in pregnancy has been associated with earlier age of menarche in daughters as well as reduced semen quality in sons. We aimed at investigating pubertal development in sons born by mothers with a high body mass index (BMI). The study included 2522 sons of mothers...... that during pregnancy in 1984-1987 were enrolled in a mother-child cohort and gave information on their pre-pregnancy height and weight from which we calculated their BMI. Information on sons' pubertal development, assessed by age when starting regular shaving, voice break, acne and first nocturnal emission...... indicators of pubertal development, results also indicated earlier pubertal development among sons of obese mothers. After excluding sons of underweight mothers in a subanalysis, we observed an inverse trend between maternal pre-pregnancy BMI and age at regular shaving, acne and first nocturnal emission...

  19. Genital examination and exposure experienced as nosocomial sexual abuse in childhood.

    Science.gov (United States)

    Money, J; Lamacz, M

    1987-12-01

    Three pediatric cases of girls, one with idiopathic precocious puberty and two with a birth defect of the sex organs, exemplify the proposition that genital exposure and the physical examination of the genitals may be experienced subjectively as nosocomial sexual abuse. Negative sequelae persisted into adulthood. The dogma of the new victimology industry is that children never lie about sexual abuse. Consequently providers of pediatric and ephebiatric (pubertal and adolescent) sexual health care already are progressively at risk of being falsely accused of nosocomial (from the Greek nosokomeion, from nosos, disease, + komeion, to take care of: pertaining to or originating in a hospital, as nosocomial disease) sexual abuse.

  20. Sexual behavior and responsiveness to sexual stimuli following laboratory-induced sexual arousal.

    Science.gov (United States)

    Both, Stephanie; Spiering, Mark; Everaerd, Walter; Laan, Ellen

    2004-08-01

    Sexual excitement can be seen as an action disposition. In this study sexual arousal was expected to generate sexual action and to increase interest and responsiveness to sexual stimuli. In two experiments, male and female participants were exposed to a neutral or a sexual film. We measured genital and subjective responses to the film, and sexual behavior following the laboratory visit. In Experiment 2, film exposure was followed by a task in which participants rated the sexual arousability of neutral and sexual pictures. Rating time of the sexual pictures served as an index for sexual interest. Responsiveness to the sexual pictures was measured by modulation of spinal tendinous (T) reflexes. Sexual activity, but not sexual desire, was higher for participants in the sexual film condition than for participants in the neutral condition. Sexual interest and responsiveness to still pictures were not higher for participants in the sexual film condition than for those in the neutral film condition. In addition, men who saw the neutral film showed a greater responsiveness to still pictures than men who saw the sexual film. The results support the view of sexual arousal as an emotional state generating action tendencies and actual sexual behavior.

  1. Postpartum Resumption of Sexual Activity, Sexual Morbidity and ...

    African Journals Online (AJOL)

    time taken to resume sexual activity, prevalence and pattern of sexual problems ... sexual intercourse included husband's request, initiation by self, cultural demand, and ... disclosure of sexual issues in some ethnic groups may also be responsible. ..... and use among postpartum adolescents in El Salvador. Am. J Obstet ...

  2. [Consumptions of Meat and Dairy Products, Zinc Intake and Pubertal Development in Adolescents in Chengdu].

    Science.gov (United States)

    Luo, Jiao; Yang, Ming-zhe; Duan, Ruo-nan; Tian, Guo; Bao, Yu-xin; Chen, Yan-rong; Xue, Hong-mei; Liu, Yan; Cheng, Guo

    2015-09-01

    To determine the associations between meat, dairy and zinc intake and pubertal development in adolescents in Chengdu. A total of 1320 children and adolescents aged 9-15 years in Chengdu were recruited using a stratified cluster sampling strategy. Dietary intake was assessed by the food frequency questionnaire (FFQ) and 3-day 24-hour dietary recall. Pubertal development was evaluated through physical examinations. Consumptions of meat and dairy, and zinc intake were compared between groups with different levels of pubertal development according to the Tanner criteria. The median age of spermarche was 13. 00 years. The boys who had had spermarche consumed more meat (including red meat) and dairy products than those who had not yet (Pmeat was positively correlated with the level of pubertal development (Pmeat and less diiry products than those who had not yet (Pproducts was negatively associated with breast development and the level of pubertal development (P meat, red meat and dairy products are associated with pubertal development in adolescents in Chengdu. However, the differences between boys and girls warrant further studies.

  3. PRE-PUBERTAL CHILDREN AND EXERCISE IN HOT AND HUMID ENVIRONMENTS: A BRIEF REVIEW

    Directory of Open Access Journals (Sweden)

    Wade H. Sinclair

    2007-12-01

    Full Text Available The ability of pre-pubertal children to regulate their body temperature under thermoneutral environments is similar to that of an adult albeit via differing routes. However, this ability is challenged when exposed to extreme environments. Thermoregulatory responses of pre-pubertal children differ from adults via adaptations that occur during growth and maturation and disadvantage children when exercising in hot and humid environments. When ambient temperatures exceed that of the skin, an influx of thermal energy from the environment increases thermal stress. When coupled with exercise, the increased thermal stress results in reduced physical performance and an increased risk of developing heat-related illness. Evidence suggesting the severity of heat-related illness is greater in pre-pubertal children than adults is inconclusive because age-related differences in thermoregulatory responses are attributed to either morphologic or functional changes. Additionally, the majority of research on pre-pubertal children exercising in the heat has been maturational or comparative studies with adults conducted in the near absence of convective cooling, complicating extrapolation to field-based environments. However, current consensus is that pre-pubertal children are disadvantaged when exercising in extreme temperatures and that care should be taken in preparing for and conducting sporting activities in hot and humid environments for pre-pubertal children

  4. Stress induced alterations in pre-pubertal ovarian follicular development in rat

    Directory of Open Access Journals (Sweden)

    Yajurvedi H.N.

    2011-12-01

    Full Text Available The objective of the study was to find out whether stress experienced during neo-natal period alters the timing of formation of pre-antral and antral follicles and if so, whether pre-treatment with CRH receptor antagonist prevents these effects in rats. New born rat pups (n= 15 were exposed to maternal separation (6 hours/ day from post-natal day (PND 1 to 7 and were killed on PND 8, 11 and 15. The time of exposure was randomly changed every day during light phase (7Am to 7Pm of the day to avoid habituation. There was a significant increase in serum corticosterone levels on PND 8 and 11 in stress group rats compared to controls indicating stress response in these pups. The ovary of both control and stressed rats contained oocytes and primary follicles on PND 8 and 11 and in showed progress of follicular development upto to pre-antral and early antral follicle formation on PND 11 and 15. However, mean number of healthy oocytes and all categories of follicles at all ages studied were significantly lower in stressed rats compared to controls. Concomitant with these changes, number of atreatic follicles showed an increase over control values in stressed rats. The increase in atresia of follicles was due to apoptosis as shown by increase in the percentage of granulosa cells showing TUNEL positive staining and caspase 3 activity. On the other hand, pre-treatment with CRH- receptor antagonist (CRH 9-41 2ng/ 0.1 ml/ rat prior to undergoing stress regime on PND 1 to 7, prevented alterations in pre- pubertal follicular development thereby indicating that the ovarian changes were due to effects of stress induced activation of HPA axis. The results indicate that, stress during neonatal phase, though does not affect timing of formation of pre-antral and antral follicles, it does enhance atresia of follicles of all categories, including follicular reserve, which may affect the reproductive potential of adults. The results, for the first time reveal that CRF

  5. Married men's first time experiences of early childbearing and their role in sexual and reproductive decision making: a qualitative study from rural Vietnam.

    Science.gov (United States)

    Klingberg-Allvin, Marie; Berggren, Vanja; Binh, Nguyen Thanh; Bijay, Bharati; Johansson, Annika

    2012-01-01

    Male partners' involvement in women's sexual and reproductive health has been increasingly emphasised in international health. A qualitative approach with open-ended qualitative interviews was used to explore young, married men's first time experiences of early childbearing, their sexual and reproductive decision making and the meanings they make of their role as husbands and fathers. The results offer a nuanced picture of the men's vulnerability in becoming young fathers and having to assume their role as family decision-makers, while still being inexperienced in matters related to the health of their wives and newborn child. Constraints to gender equality and traditional norms and values continue to pose barriers to both young men and women making independent decisions in relation to marriage and childbearing. Men's involvement is necessary in healthcare programmes designed to improve women's sexual and reproductive health and the health of the newborn. Young, first-time fathers, in particular, need support and empowerment.

  6. Maternal swimming exercise during pregnancy attenuates anxiety/depressive-like behaviors and voluntary morphine consumption in the pubertal male and female rat offspring born from morphine dependent mothers.

    Science.gov (United States)

    Torabi, Masoumeh; Pooriamehr, Alireza; Bigdeli, Imanollah; Miladi-Gorji, Hossein

    2017-09-01

    This study was designed to examine whether maternal swimming exercise during pregnancy would attenuate prenatally morphine-induced anxiety, depression and voluntary consumption of morphine in the pubertal male and female rat offspring. Pregnant rats during the development of morphine dependence were allowed to swim (30-45min/d, 3days per a week) on gestational days 11-18. Then, the pubertal male and female rat offspring were tested for the elevated plus-maze (EPM), sucrose preference test (SPT) and voluntary morphine consumption using a two-bottle choice (TBC) paradigm. The results showed that male and female rat offspring born of the swimmer morphine-dependent mothers exhibited an increase in EPM open arm time and entries, higher levels of sucrose preference than their sedentary control mothers. Voluntary consumption of morphine was less in the male and female rat offspring born of the swimmer morphine-dependent mothers as compared with their sedentary control mothers during three periods of the intake of drug. Thus, swimming exercise in pregnant morphine dependent mothers decreased anxiety, depressive-like behavior and also the voluntary morphine consumption in the pubertal male and female offspring, which may prevent prenatally morphine-induced behavioral sensitization in offspring. Copyright © 2017 Elsevier B.V. All rights reserved.

  7. Effects on steroid hormones secretion resulting from the acute stimulation of sectioning the superior ovarian nerve to pre-pubertal rats

    Directory of Open Access Journals (Sweden)

    Morales-Ledesma Leticia

    2012-10-01

    Full Text Available Abstract In the adult rat, neural signals arriving to the ovary via the superior ovarian nerve (SON modulate progesterone (P4, testosterone (T and estradiol (E2 secretion. The aims of the present study were to analyze if the SON in the pre-pubertal rat also modulates ovarian hormone secretion and the release of follicle stimulating hormone (FSH and luteinizing (LH hormone. P4, T, E2, FSH and LH serum levels were measured 30 or 60 minutes after sectioning the SON of pre-pubertal female rats. Our results indicate that the effects on hormone levels resulting from unilaterally or bilaterally sectioning the SON depends on the analyzed hormone, and the time lapse between surgery and autopsy, and that the treatment yielded asymmetric results. The results also suggest that in the pre-pubertal rat the neural signals arriving to the ovaries via the SON regulate the enzymes participating in P4, T and E2 synthesis in a non-parallel way, indicating that the mechanisms regulating the synthesis of each hormone are not regulated by the same signals. Also, that the changes in the steroids hormones are not explained exclusively by the modifications in gonadotropins secretion. The observed differences in hormone levels between rats sacrificed 30 and 60 min after surgery reflect the onset of the compensatory systems regulating hormones secretion.

  8. Attachment, parenting styles and bullying during pubertal years.

    Science.gov (United States)

    van der Watt, Ronél

    2014-01-01

    Research that focuses on combining attachment, parenting styles, bullying and the reciprocal nature thereof in the parent-adolescent and peer relationships is limited. The bio-psychosocial changes that adolescents experience open up broader social realities and are perceived differently by parents and adolescents. Attachment processes and parenting styles may elicit dissimilar perceptions. These processes are also associated with the multifaceted dynamics of bullying. The aim of the article is to advocate for research on the possible link between the implications of attachment, parenting styles and bullying. Exploring the association between attachment, parenting styles and bullying can deepen the understanding of the developmental challenges within the parent-adolescent relationship, add insight to the different perceptions of adolescents and parents, and complement intervention programmes accordingly. Firstly, this article outlines bio-psychosocial changes in the pubertal years as related to the social realities of the adolescent. Secondly, a discussion on the concepts 'attachment', 'parenting styles', 'bullying', and the potential link between these concepts will follow. Thirdly, an outline of the clinical implications of the apparent association between these concepts is given. The article concludes with recommendations that researchers can consider while exploring the relationship between attachment, parenting styles, and bullying and the delineation thereof in the parent-adolescent relationship.

  9. Changes over time in sexual behaviour among young people with different levels of educational attainment in Tanzania

    Directory of Open Access Journals (Sweden)

    Elizabeth Fearon

    2012-06-01

    Full Text Available Background: HIV prevalence trends in Tanzania differ between socioeconomic groups. While HIV prevalence was initially higher among those with higher levels of educational attainment, it has fallen fastest among these groups. Among those with lower levels of education HIV prevalence has been stable. The behavioural dynamics underlying this phenomenon remain unclear, and a theory to guide interpretation of these trends and enable predictions of future patterns has not emerged. Methods: We analysed data from two large nationally representative surveys conducted in Tanzania in 2003/2004 and 2007/2008. We focused on young people aged 15 to 24 years and explored reports of (i first sex, (ii having had more than one sexual partner in the last year and (iii unprotected last sex with a non-cohabiting partner. Our analysis explored whether the behaviours differed by educational attainment in 2003/2004 and in 2007/2008, and whether changes over time in these behaviours differed between educational groups. Results: The rate of first sex was lower among more educated males in 2007/2008 but not in 2003/2004, and among females in both surveys. The change over time in educational patterning of the rate of first sex in males was mostly due to a declining rate among the secondary educated groups. Among males, having had more than one sexual partner in the last year was associated with lower education in 2003/2004 and in 2007/2008. Among females, those with less education were more likely to report more than one partner in 2003/2004, although by 2007/2008 there was little association between education and reporting more than one partner. Unprotected last sex with a non-cohabiting partner was less common among the more educated. Among both sexes this decreased over time among those with no education and increased among those with secondary education. Conclusions: Patterns of behaviour suggest that differences in HIV incidence might explain trends in HIV prevalence

  10. Effects of perinatal exposure to diazepam on the development of sexual behavior and neuroendocrine functions in male rats.

    Directory of Open Access Journals (Sweden)

    Arif Siddiqui

    2008-06-01

    Full Text Available Developmental exposure with diazepam when coinciding with the ontogenesis of its receptors may be crucial for the induction of long-term functional disturbances in the rat brain. To investigate the possibility of intervention in the sexually dimorphic behavior of reproduction and the under lying morphological and hormonal basis the time-mated female rats were treated with 2.5 mg/kg, 5 mg/kg and 10 mg/kg, i.p.(n = 6-8 separately. Treatment was continued from gestation day 15 till delivery and further continued to neonates 5 days, postnatally. Control group (n= 5-8 given saline also followed the same treatment protocol. Sexual behavior in the male offspring at adulthood born to diazepam-exposed rats was enhanced, both in dose-dependent and time-dependent manner (p<0.01. Accordingly plasma LH and testosterone concentration both in plasma and testis was also influenced. Compared to controls treated animals also showed complete abolition of spermatogenesis and drastically reduced testicular steroidogenesis. Our findings, thus support the hypothesis that like psychoactive drugs benzodiazepines sedatives that crosses the blood brain barrier during the critical period of brain sexual differentiation offer serious risk of abnormal post-pubertal reproductive functions in the male rat.

  11. Growth patterns in brooding dinosaurs reveals the timing of sexual maturity in non-avian dinosaurs and genesis of the avian condition.

    Science.gov (United States)

    Erickson, Gregory M; Curry Rogers, Kristina; Varricchio, David J; Norell, Mark A; Xu, Xing

    2007-10-22

    The timing of sexual maturation in non-avian dinosaurs is not known. In extant squamates and crocodilians it occurs in conjunction with the initial slowing of growth rates as adult size is approached. In birds (living dinosaurs) on the other hand, reproductive activity begins well after somatic maturity. Here we used growth line counts and spacing in all of the known brooding non-avian dinosaurs to determine the stages of development when they perished. It was revealed that sexual maturation occurred well before full adult size was reached-the primitive reptilian condition. In this sense, the life history and physiology of non-avian dinosaurs was not like that of modern birds. Palaeobiological ramifications of these findings include the potential to deduce reproductive lifespan, fecundity and reproductive population sizes in non-avian dinosaurs, as well as aid in the identification of secondary sexual characteristics.

  12. Category Specificity of Self-Reported Sexual Attraction and Viewing Times to Male and Female Models in a Large U.S. Sample: Sex, Sexual Orientation, and Demographic Effects.

    Science.gov (United States)

    Lippa, Richard A

    2017-01-01

    Recent research has documented large and robust sex differences in the category specificity of self-reported sexual attraction and viewing times to men and women, with men showing more polarized responses to the two sexes than women. However, this research has been limited by the use of small and restricted samples. To address this, the current study assessed a representative sample of more than 2800 U.S. adults on demographic and attitudinal variables and on two measures of category specificity: one based on self-reported sexual attraction and the other based on viewing times to male and female swimsuit models. Key findings were replicated. On average, men were considerably more category specific in self-reported sexual attraction and viewing times than women, and this was true for both heterosexual and homosexual participants. Self-identified bisexual and asexual participants tended to be lower on category specificity than other groups. Although demographic and attitudinal factors such as age, ethnicity, state and region of residence, social class, political liberalism-conservatism, and religiousness were sometimes weakly related to category specificity, sex differences in category specificity remained robust despite demographic and attitudinal variation.

  13. Different patterns of sexual identity development over time: implications for the psychological adjustment of lesbian, gay, and bisexual youths.

    Science.gov (United States)

    Rosario, Margaret; Schrimshaw, Eric W; Hunter, Joyce

    2011-01-01

    Despite research documenting variability in the sexual identity development of lesbian, gay, and bisexual (LGB) youths, it remains unclear whether different developmental patterns have implications for the psychological adjustment of LGB youths. This report longitudinally examines whether different patterns of LGB identity formation and integration are associated with indicators of psychological adjustment among an ethnically diverse sample of 156 LGB youths (ages 14-21) in New York City. Although differences in the timing of identity formation were not associated with psychological adjustment, greater identity integration was related to less depressive and anxious symptoms, fewer conduct problems, and higher self-esteem both cross-sectionally and longitudinally. Individual changes in identity integration over time were associated with all four aspects of psychological adjustment, even after controlling for rival hypotheses concerning family and friend support, gay-related stress, negative social relationships, and other covariates. These findings suggest that difficulties in developing an integrated LGB identity may have negative implications for the psychological adjustment of LGB youths and that efforts to reduce distress among LGB youths should address the youths' identity integration.

  14. Rural Location and Relative Location: Adding Community Context to the Study of Sexual Assault Survivor Time Until Presentation for Medical Care.

    Science.gov (United States)

    Johnson, Ingrid Diane; Hiller, Matthew L

    2016-08-12

    Despite a strong empirical base linking community context and proximity to resources to individual health care access, studies examining predictors of sexual assault survivor time until presentation for medical care have not yet examined these relationships. This study addresses this gap. The data included retrospective records on a sample of 1,630 female survivors who reported their sexual assault to law enforcement and were subsequently seen by a sexual assault nurse examiner (SANE) in one of eight Alaskan communities between the years 1996 and 2006. Logistic regression models were used to determine whether delays in presentation (presentation 12 hr or more after assault) differed for women presenting in unique communities (rural location), and between those whose assault and exam occurred in different communities versus occurring in the same community (relative location). Although rural location did not seem to have a unique impact on time until presentation, differing locations (i.e., relative location) of assaults and exams increased the likelihood of delays in presentation. Non-American Indian/Alaska Native race/ethnicity and knowing one's assailant(s) also increased the likelihood of delays. These results indicate that in addition to a need for further research, there is a need for more appropriate and reliable sexual assault medical services across communities, and that survivors assaulted by known assailants should be targeted in efforts to reduce time until presentation.

  15. Increasing prevalence of HIV infection among first time clients in Italian drug treatment services - is it sexual transmission?

    Science.gov (United States)

    Cruciani, Mario; Wiessing, Lucas; Serpelloni, Giovanni; Genetti, Bruno; Andreotti, Alessandra; Iulia, Carpignano; Zermiani, Monica; Suligoi, Barbara

    2015-04-30

    Over the last two decades, the proportion of people who inject drugs among newly reported HIV cases in Italy has been continuously declining. This trend is reflected in the prevalence of HIV infection among problem drug users followed in drug treatment services. We report nationwide trends in the prevalence of HIV and HCV among tested clients in charge to drug addiction services from 2005 to 2011. Data on the prevalence of HIV and HCV among drug users from public drug treatment services across Italy were collected and analyzed for the period from 2005 to 2011. Prevalence of HIV and HCV were compared between clients returning to treatment and those entering treatment for the first time, and by gender. Due to the high percentage of missing data, the "inverse probability weight" method was used. Trends in testing uptake were also analysed. A significant decrease of HIV and HCV prevalence is observed among all PDUs entering treatment (from 14.7% to 11.1% and from 61.6% to 50%, respectively, in 2005-2011). By contrast, among those entering the services for the first time, after an initial decline the prevalence of HIV infection steadily increased in both sexes, from 2.2% in 2009 to 5.3% in 2011. Self-reported injecting rates in this group decreased over time, and in 2011 the proportion reporting drug injecting was lower among new clients than in people returning to services (14.5 vs. 34.4%). We also observed a progressive and significant reduction in HIV and HCV testing in drug treatment services. Changes in injection practice and type of drugs used, coupled with a concurrent reduction in HCV prevalence, do not support drug injection as the main explanation for an increased HIV transmission in people entering drug treatment services for the first time. While reductions in testing rates raise concerns over data quality, the possibility of increased sexual transmission needs to be considered.

  16. Expression of 11β-hydroxysteroid dehydrogenase type 1 and glucocorticoid receptors in reproductive tissue of male horses at different stages of sexual maturity.

    Science.gov (United States)

    Herrera-Luna, C V; Budik, S; Helmreich, M; Walter, I; Aurich, C

    2013-04-01

    Glucocorticoids (GCs) as mediators of the stress response may affect Leydig cell function by inhibiting either luteinizing hormone receptor expression or testosterone biosynthesis. The isozymes 11β-hydroxysteroid dehydrogenase (11βHSD) 1 and 11βHSD2 control the intracellular cortisol levels. Little is known about the effects of stress on fertility in the equine. The objective of the present study was to determine the presence and cellular localization of glucocorticoid receptors (GCR) and glucocorticoid-metabolizing enzymes (11βHSD1 and 11βHSD2) in equine epididymal and testicular tissue with special regard to sexual maturation. Testicular and epididymal tissue was collected from 21 healthy stallions, and four age groups were designed: pre-pubertal, young, mature and older horses. Immunohistochemistry (IHC) analysis and quantitative real-time PCR (qRT-PCR) were used. Pre-pubertal horses showed higher testicular gene expression of 11βHSD1, 11βHSD2 and GCR than horses of all other groups (p horses. In mature stallions, expression of 11βHSD enzymes and the oxidative 11βHSD activity in Leydig cells and epididymal basal and principal cells suggest a protective role on these tissues contributing to physiological intracellular glucocorticoid concentrations.

  17. Time series analysis of sexual assault case characteristics and the 2007-2008 period of post-election violence in Kenya.

    Directory of Open Access Journals (Sweden)

    Michael P Anastario

    Full Text Available Following the declaration that President Mwai Kibaki was the winner of the Kenyan presidential election held on December 27, 2007, a period of post-election violence (PEV took place. In this study, we aimed to identify whether the period of PEV in Kenya was associated with systematic changes in sexual assault case characteristics.Medical records of 1,615 patients diagnosed with sexual assault between 2007 and 2011 at healthcare facilities in Eldoret (n = 569, Naivasha (n = 534, and Nakuru (n = 512 were retrospectively reviewed to examine characteristics of sexual assault cases over time. Time series and linear regression were used to examine temporal variation in case characteristics relative to the period of post-election violence in Kenya. Key informant interviews with healthcare workers at the sites were employed to triangulate findings. The time series of sexual assault case characteristics at these facilities were examined, with a specific focus on the December 2007-February 2008 period of post-election violence. Prais-Winsten estimates indicated that the three-month period of post-election violence was associated with a 22 percentage-point increase in cases where survivors did not know the perpetrator, a 20 percentage-point increase in cases with more than one perpetrator, and a 4 percentage-point increase in cases that had evidence of abdominal injury. The post-election violence period was also associated with an 18 percentage-point increase in survivors waiting >1 month to report to a healthcare facility. Sensitivity analyses confirmed that these characteristics were specific to the post-election violence time period.These results demonstrate systematic patterns in sexual assault characteristics during the PEV period in Kenya.

  18. Teenage Sexuality

    Science.gov (United States)

    ... Stages Listen Español Text Size Email Print Share Teenage Sexuality Page Content Article Body Sex and sexuality ... have sexual intercourse? Will having sex help my relationship? If I am attracted to a same-sex ...

  19. Developmental Trajectories of Religiosity, Sexual Conservatism and Sexual Behavior among Female Adolescents

    Science.gov (United States)

    Aalsma, Matthew C.; Woodrome, Stacy E.; Downs, Sarah M.; Hensel, Devon; Zimet, Gregory D.; Orr, Don P.; Fortenberry, J. Dennis

    2013-01-01

    Understanding the role of socio-sexual cognitions and religiosity on adolescent sexual behavior could guide adolescent sexual health efforts. The present study utilized longitudinal data from 328 young women to assess the role of religion and socio-sexual cognitions on sexual behavior accrual (measuring both coital and non-coital sexual behavior). In the final triple conditional trajectory structural equation model, religiosity declined over time and then increased to baseline levels. Additionally, religiosity predicted decreased sexual conservatism and decreased sexual conservatism predicted increased sexual behavior. The final models are indicative of young women's increasing accrual of sexual experience, decreasing sexual conservatism and initial decreasing religiosity. The results of this study suggest that decreased religiosity affects the accrual of sexual experience through decreased sexual conservatism. Effective strategies of sexual health promotion should include an understanding of the complex role of socio-sexual attitudes with religiosity. PMID:24215966

  20. Husband's Reaction to His Wife's Sexual Rejection Is Predicted by the Time She Spends With Her Male Friends but Not Her Male Coworkers.

    Science.gov (United States)

    DeLecce, Tara; Barbaro, Nicole; Mohamedally, Derek; Shackelford, Todd K

    2017-01-01

    Males among many species, including humans, evaluate cues of sperm competition risk and adjust accordingly their sperm competition tactics. The number of potential sexual rivals can serve as an index of sperm competition risk. Therefore, men may adjust their in-pair copulatory interest in accordance with the presence of sexual rivals. Using self-reports from 45 married men, we test the hypotheses that the time a man's wife spends with other men-either male friends or male coworkers-will positively predict a man's copulatory interest in his wife (Hypothesis 1) and his anger (Hypothesis 2), upset (Hypothesis 3), and frustration (Hypothesis 4) in response to his wife's sexual rejection. The results show that the time wives spend with male friends (but not male coworkers) predicts their husbands' anger, upset, and frustration in response to sexual rejection, providing support for Hypotheses 2-4. Discussion highlights novel contributions of the current research and provides a potential explanation for the discrepant findings regarding male friends versus male coworkers.

  1. Husband’s Reaction to His Wife’s Sexual Rejection Is Predicted by the Time She Spends With Her Male Friends but Not Her Male Coworkers

    Directory of Open Access Journals (Sweden)

    Tara DeLecce

    2017-04-01

    Full Text Available Males among many species, including humans, evaluate cues of sperm competition risk and adjust accordingly their sperm competition tactics. The number of potential sexual rivals can serve as an index of sperm competition risk. Therefore, men may adjust their in-pair copulatory interest in accordance with the presence of sexual rivals. Using self-reports from 45 married men, we test the hypotheses that the time a man’s wife spends with other men—either male friends or male coworkers—will positively predict a man’s copulatory interest in his wife (Hypothesis 1 and his anger (Hypothesis 2, upset (Hypothesis 3, and frustration (Hypothesis 4 in response to his wife’s sexual rejection. The results show that the time wives spend with male friends (but not male coworkers predicts their husbands’ anger, upset, and frustration in response to sexual rejection, providing support for Hypotheses 2–4. Discussion highlights novel contributions of the current research and provides a potential explanation for the discrepant findings regarding male friends versus male coworkers.

  2. Xenoestrogens diethylstilbestrol and zearalenone negatively influence pubertal rat's testis.

    Directory of Open Access Journals (Sweden)

    Katarzyna Marchlewska

    2010-01-01

    Full Text Available The aim of this study was to assess the impact of xenoestrogens: diethylstilbestrol (DES and zearalenone (ZEA on rat's pubertal testis and to compare it with the effect of natural estrogen - 17beta-estradiol (E. Male Wistar rats were daily, subcutaneously injected at 5th-15th postnatal days (p.d. with E (1.25 or 12.5 mug or DES (1.25 or 12.5 mug or ZEA (4 or 40 mug or vehicle. At 16th p.d. testes were dissected, weighted, and paraffin embedded. Following parameters were assessed: diameter and length of seminiferous tubule, numbers of spermatogonia A+intermediate+B (A/In/B, preleptotene spermatocytes (PL, leptotene+zygotene+pachytene spermatocytes (L/Z/PA and Sertoli cells per testis. Testes weight, seminiferous tubule diameter and length were decreased by both doses of E, DES and ZEA. DES effect was the strongest, but its influence on testis weight and seminiferous tubule length, on the contrary to E and ZEA, was not dose-dependent. Similarly, DES in both doses had the most severe negative impact on the number of germ and Sertoli cells. The negative influence of E on germ cells was less pronounced. The negative effect of ZEA was seen only after administration of the higher dose on spermatogonia number, while DES and E decreased A/In/B number more evidently. Sertoli cell number were decreased after both doses of E. ZEA40 decreased Sertoli cell number while ZEA4 had no effect. Conclusion: exposure of prepubertal male rat to DES has the strongest detrimental effect on the developing testis in comparison to E and ZEA. Both, E and DES, decreased number of germ and Sertoli cells, diminished seminiferous tubule diameter, length and testis weight. ZEA had much more weaker effect than the potent estrogens.

  3. Sexual Health

    Science.gov (United States)

    ... Basic HIV/AIDS information and resources for prevention LGBT Health Information for lesbian, gay, bisexual, or transgender (LGBT) individuals Sexual Health News & Information Understanding Sexual Health ...

  4. Impact of Pubertal Development and Physical Activity on Heart Rate Variability in Overweight and Obese Children in Taiwan

    Science.gov (United States)

    Chen, Su-Ru; Chiu, Hung-Wen; Lee, Yann-Jinn; Sheen, Tzong-Chi; Jeng, Chii

    2012-01-01

    Child obesity is frequently associated with dysfunction of autonomic nervous system. Children in pubertal development were suggested to be vulnerable to autonomic nervous system problems such as decrease of heart rate variability from dysregulation of metabolic control. This study explored the influence of pubertal development on autonomic nervous…

  5. Adolescents' Increasing Stress Response to Social Evaluation: Pubertal Effects on Cortisol and Alpha-Amylase during Public Speaking

    Science.gov (United States)

    van den Bos, Esther; de Rooij, Mark; Miers, Anne C.; Bokhorst, Caroline L.; Westenberg, P. Michiel

    2014-01-01

    Stress responses to social evaluation are thought to increase during adolescence, which may be due to pubertal maturation. However, empirical evidence is scarce. This study is the first to investigate the relation between pubertal development and biological responses to a social-evaluative stressor longitudinally. Participants performed the Leiden…

  6. Adolescents' Increasing Stress Response to Social Evaluation: Pubertal Effects on Cortisol and Alpha-Amylase during Public Speaking

    Science.gov (United States)

    van den Bos, Esther; de Rooij, Mark; Miers, Anne C.; Bokhorst, Caroline L.; Westenberg, P. Michiel

    2014-01-01

    Stress responses to social evaluation are thought to increase during adolescence, which may be due to pubertal maturation. However, empirical evidence is scarce. This study is the first to investigate the relation between pubertal development and biological responses to a social-evaluative stressor longitudinally. Participants performed the Leiden…

  7. Impact of Pubertal Development and Physical Activity on Heart Rate Variability in Overweight and Obese Children in Taiwan

    Science.gov (United States)

    Chen, Su-Ru; Chiu, Hung-Wen; Lee, Yann-Jinn; Sheen, Tzong-Chi; Jeng, Chii

    2012-01-01

    Child obesity is frequently associated with dysfunction of autonomic nervous system. Children in pubertal development were suggested to be vulnerable to autonomic nervous system problems such as decrease of heart rate variability from dysregulation of metabolic control. This study explored the influence of pubertal development on autonomic nervous…

  8. Maths performance as a function of sex, laterality, and age of pubertal onset.

    Science.gov (United States)

    Sappington, John; Topolski, Richard

    2005-07-01

    Sex differences in math/spatial performance demand explanations. Within the biological view, the complexity and number of variables make the explanation difficult at best. Laterality and age of pubertal onset have been investigated prominently in this context but rarely considered as interactions in the same study. Some 468 college subjects with SAT MATH (SAT M) scores were divided into 12 groups defined by sex, laterality, and age (early, middle, and late) of pubertal onset. Significant main effects for sex and age of onset emerged, as did an interaction between lateral preference and pubertal onset. Generally males outperformed females. The combination of maleness, sinistrality, and early maturation was associated with high SAT M scores. Sinistrality and late maturation among females predicted very poor math performance.

  9. Computerized assessment of pedophilic sexual interest through self-report and viewing time: reliability, validity, and classification accuracy of the affinity program.

    Science.gov (United States)

    Mokros, Andreas; Gebhard, Michael; Heinz, Volker; Marschall, Roland W; Nitschke, Joachim; Glasgow, David V; Gress, Carmen L Z; Laws, D Richard

    2013-06-01

    Affinity is a computerized assessment tool that combines viewing time and self-report measures of sexual interest. The present study was designed to assess the diagnostic properties of Affinity with respect to sexual interest in prepubescent children. Reliability of both self-report and viewing time components was estimated to be high. The group profile of a sample of pedophilic adult male child molesters (n = 42, all of whom admitted their offenses) differed from the group profiles of male community controls (n = 95) and male nonsexual offenders (n = 27), respectively. More specifically, both ratings and viewing times for images showing small children or prejuvenile children were significantly higher within the child molester sample than in either of the other two groups, attesting to the validity of the measures. Overall classification accuracy, however, was mediocre: A multivariate classification routine yielded 50% sensitivity for child molester status at the cost of 13% false positives. The implications for forensic use of Affinity are discussed.

  10. The Persistence of Sperm and the Development of Time Since Intercourse (TSI) Guidelines in Sexual Assault Cases at Forensic Science Ireland, Dublin, Ireland.

    Science.gov (United States)

    Casey, David G; Domijan, Katarina; MacNeill, Sarah; Rizet, Damien; O'Connell, Declan; Ryan, Jennifer

    2017-05-01

    The persistence of sperm using confirmatory microscopic analysis, the persistence of sperm with tails, time since intercourse (TSI) analysis, and results from the acid phosphatase (AP) reaction from approximately 5581 swabs taken from circa 1450 sexual assault cases are presented. The observed proportions of sperm in the vagina and anus declines significantly after 48 h TSI, and sperm on oral swabs were observed up to 15 h TSI. The AP reaction as a predictor of sperm on intimate swabs is questioned. All AP reaction times gave a low true positive rate; 23% of sperm-positive swabs gave a negative AP reaction time. We show the AP reaction is an unsafe and an unreliable predictor of sperm on intimate swabs. We propose that TSI not AP informs precase assessment and the evaluative approach for sexual assault cases. To help inform an evaluative approach, TSI guidelines are presented. © 2016 American Academy of Forensic Sciences.

  11. Endothelial function in pre-pubertal children at risk of developing cardiomyopathy: a new frontier

    Directory of Open Access Journals (Sweden)

    Aline Cristina Tavares

    2012-01-01

    Full Text Available Although it is known that obesity, diabetes, and Kawasaki's disease play important roles in systemic inflammation and in the development of both endothelial dysfunction and cardiomyopathy, there is a lack of data regarding the endothelial function of pre-pubertal children suffering from cardiomyopathy. In this study, we performed a systematic review of the literature on pre-pubertal children at risk of developing cardiomyopathy to assess the endothelial function of pre-pubertal children at risk of developing cardiomyopathy. We searched the published literature indexed in PubMed, Bireme and SciELO using the keywords 'endothelial', 'children', 'pediatric' and 'infant' and then compiled a systematic review. The end points were age, the pubertal stage, sex differences, the method used for the endothelial evaluation and the endothelial values themselves. No studies on children with cardiomyopathy were found. Only 11 papers were selected for our complete analysis, where these included reports on the flow-mediated percentage dilatation, the values of which were 9.80±1.80, 5.90±1.29, 4.50±0.70, and 7.10±1.27 for healthy, obese, diabetic and pre-pubertal children with Kawasaki's disease, respectively. There was no significant difference in the dilatation, independent of the endothelium, either among the groups or between the genders for both of the measurements in children; similar results have been found in adolescents and adults. The endothelial function in cardiomyopathic children remains unclear because of the lack of data; nevertheless, the known dysfunctions in children with obesity, type 1 diabetes and Kawasaki's disease may influence the severity of the cardiovascular symptoms, the prognosis, and the mortality rate. The results of this study encourage future research into the consequences of endothelial dysfunction in pre-pubertal children.

  12. Helping Teens Resist Sexual Pressure

    Science.gov (United States)

    ... Size Email Print Share Helping Teens Resist Sexual Pressure Page Content Article Body Teens are more likely ... time they had intercourse. Helping Teens Resist Sexual Pressure “The pressure on teenagers to have sex is ...

  13. [Dietary Fiber and Pubertal Development among Children and Adolescents--a Cross-sectional Study in Chengdu, Sichuan].

    Science.gov (United States)

    Tian, Guo; Liu, Yan; Xue, Hong-mei; Luo, Jiao; Chen, Yan-rong; Bao, Yu-xin; Duan, Ruo-nan; Yang, Ming-zhe; Cheng, Guo

    2016-03-01

    To determine the association between intake of dietary fiber and pubertal development among children and adolescents in Chengdu. A cross-sectional survey was undertaken in 1 340 children and adolescents aged 9-15 years. Data about dietary intake were collected through 24-h dietary self-recall. Pubertal development was measured by trained investigators using Tanner criteria. Consumptions of total fiber and fiber from different sources were compared among the participants with different stages of pubertal development. Data from 1 328 children and adolescents were analyzed. Boys (n = 667) at a later stage of pubertal development consumed less total fiber and fruit fiber than those at an earlier stage (P fiber than those at an earlier stage (P Dietary fiber intake, especially fruit fiber, is lower in children and adolescents with early commencement of puberty development. Further studies are needed to establish the relationship between dietary fiber and pubertal development.

  14. Sexuality Education for Children and Adolescents.

    Science.gov (United States)

    Breuner, Cora C; Mattson, Gerri

    2016-08-01

    The purpose of this clinical report is to provide pediatricians updated research on evidence-based sexual and reproductive health education conducted since the original clinical report on the subject was published by the American Academy of Pediatrics in 2001. Sexuality education is defined as teaching about human sexuality, including intimate relationships, human sexual anatomy, sexual reproduction, sexually transmitted infections, sexual activity, sexual orientation, gender identity, abstinence, contraception, and reproductive rights and responsibilities. Developmentally appropriate and evidence-based education about human sexuality and sexual reproduction over time provided by pediatricians, schools, other professionals, and parents is important to help children and adolescents make informed, positive, and safe choices about healthy relationships, responsible sexual activity, and their reproductive health. Sexuality education has been shown to help to prevent and reduce the risks of adolescent pregnancy, HIV, and sexually transmitted infections for children and adolescents with and without chronic health conditions and disabilities in the United States.

  15. Serum levels of INSL3, AMH, Inhibin B and Testosterone during pubertal transition in healthy boys

    DEFF Research Database (Denmark)

    Lindhardt Johansen, Marie; Anand-Ivell, Ravinder; Mouritsen, Annette;

    2014-01-01

    to luteinizing hormone (LH), follicle-stimulating hormone (FSH), testosterone, inhibin B, and anti-Müllerian hormone (AMH) during puberty in healthy boys.MethodsTen boys were included from the longitudinal part of the COPENHAGEN Puberty Study. Pubertal evaluation, including testicular volume, was performed......IntroductionInsulin-like factor 3 (INSL3) is a promising marker of Leydig cell function with potentially high clinical relevance. Limited data of INSL3 levels in relation to other reproductive hormones in healthy pubertal boys exist.AimTo evaluate longitudinal serum changes in INSL3 compared...

  16. Electro convulsive therapy in a pre-pubertal child with severe depression.

    Directory of Open Access Journals (Sweden)

    Russell P

    2002-10-01

    Full Text Available Electro Convulsive Therapy (ECT in pre-pubertal children is a controversial and underreported treatment. Even though the effectiveness and side effects of ECT in adolescents are comparable with those in adults, there is a pervasive reluctance to use ECT in children and adolescents. We report the case of a pre-pubertal child in an episode of severe depression with catatonic features, where a protracted course of ECT proved life-saving in spite of prolonged duration of seizures and delayed response to treatment. The case illustrates the safety and efficacy of ECT in children. Relevant literature is also reviewed along with the case report.

  17. Pubertal development and fertility in survivors of childhood acute myeloid leukemia treated with chemotherapy only

    DEFF Research Database (Denmark)

    Molgaard-Hansen, Lene; Skou, Anne-Sofie; Juul, Anders

    2013-01-01

    More than 60% of children with acute myeloid leukemia (AML) become long-term survivors. Most are cured using chemotherapy without hematopoietic stem cell transplantation (HSCT). We report on pubertal development and compare self-reported parenthood among AML survivors and their siblings.......More than 60% of children with acute myeloid leukemia (AML) become long-term survivors. Most are cured using chemotherapy without hematopoietic stem cell transplantation (HSCT). We report on pubertal development and compare self-reported parenthood among AML survivors and their siblings....

  18. Mutation analysis of cathepsin C gene in a Chinese patient with pre-pubertal periodontitis

    Institute of Scientific and Technical Information of China (English)

    YANG Yuan; BAI Xiao-wen; SONG Shu-juan; GE Li-hong; CAO Cai-fang

    2005-01-01

    @@ Pre-pubertal periodontitis (PPP) is a rare and rapidly progressive form of early onset periodontitis resulting in premature tooth loss of primary and permanent dentitions. Mutations in cathepsin C (CTSC) gene have been found in patients with pre-pubertal periodontitis and Papillon-Lefevre syndrome which also characterized with severe periodontitis and palmoplantar hyperkera-tosis.1-3 To date, more than 40 mutations of CTSC gene have been identified in ethnically diverse people worldwide.4 However, there is no such genetic analysis in China. In the present study, we report the mutation analysis of a Chinese patient with PPP.

  19. Effect of zeranol on sexual development of crossbred bulls.

    Science.gov (United States)

    Godfrey, R W; Randel, R D; Rouquette, F M

    1989-07-01

    Three groups of 1/2 Simmental X 1/4 Brahman X 1/4 Hereford bull calves were used during two different years to study effects of zeranol on sexual development. At 154 d of age, half the calves were implanted with 36 mg zeranol and half, not implanted, served as controls. Implanted calves were reimplanted at 90-d intervals throughout the trial (9 mo) each year. Trial 1 was conducted with 24 calves and Trial 2 was conducted the following year with 10 bulls. Twenty-four days after weaning (200 d of age) and at 28-d intervals thereafter, bulls in drylot in Trial 1 were weighted, scrotal circumference (SC) was measured and an ejaculate of semen was collected by electroejaculation to determine puberty. At these times, bulls were given 200 micrograms of GnRH i.m. and blood was collected at 0, 1, 2, 3, 4 and 5 h after GnRH. Serum concentrations of LH and testosterone (TEST) were determined. At slaughter, testis weight, length and circumference and pubertal status were recorded. Bulls implanted with zeranol had smaller SC than control bulls during the entire 9-mo period (P less than .0001). More control bulls reached puberty than did implanted bulls (82.4 vs 23.5%, respectively; P less than .001). Control bulls had larger testis measurements at slaughter (P less than .0001). Implants did not alter total weight gain or ADG (P greater than .10).(ABSTRACT TRUNCATED AT 250 WORDS)

  20. Sexual Harassment and Sexual Bulllying (For Teens)

    Science.gov (United States)

    ... Can I Help Someone Who's Being Bullied? Volunteering Sexual Harassment and Sexual Bullying KidsHealth > For Teens > Sexual Harassment and Sexual ... is being sexually harassed or bullied. What Are Sexual Bullying and Harassment? Just like other kinds of ...

  1. Childhood Sexual Abuse

    Directory of Open Access Journals (Sweden)

    Evrim Aktepe

    2009-08-01

    Full Text Available Sexual abuse is defined as use of child or adolescent by the adults for satisfying of sexual urges and needs with forcing, threatening or tricking. Sexual abuse can be in the form of sexual abuse without touch, sexual touch, interfemoral intercourse, sexual penetration, and sexual exploitation. The prevalence of sexual abuse is reported as 10-40%. It is seen in female four times more than in males. Abusers are frequently male, only 5-15% of them are female. The abuse by females is usually towards male child. Thirty-fifty percent of abuse cases among child and adolescent are outside the family including strangers or familiar person. Some features of abusers are introvert personality, pedophilic and antisocial personality. Most of the abusers have a history of sexual abuse or aggression during childhood. Sexual intercourse between two people who are not allowed to marry by law is called as incest. Family pattern of incest is defined globally as disorganized and dysfunctional. The most commonly reported familial pattern is rigid and patriarchal family pattern with a harsh father using force quite frequently. The clinical features and impacts of the sexual abuse on the child varies according to the relation between abusers and the child, form of abuse, duration of abuse, presence of physical assault, developmental phase, child age and psychological development before the abuse. Sexual abuse history may result in psychiatric disorders including anxiety, depression, substance dependence, suicide act, borderline personality disorder, posttraumatic stress disorder. Abuse negatively affects interpersonal relationships and self esteem of abused individuals. Several studies reported close association between risky sexual behaviors in adulthood and a history of of sexual abuse during childhood. Four traumatic dynamics including traumatic sexuality with abuse, feeling of betrayal, weakness, and stigmatization exist in childhood abuse. Trauma can cause

  2. Longitudinal changes in adolescent risk-taking: a comprehensive study of neural responses to rewards, pubertal development, and risk-taking behavior.

    Science.gov (United States)

    Braams, Barbara R; van Duijvenvoorde, Anna C K; Peper, Jiska S; Crone, Eveline A

    2015-05-01

    Prior studies have highlighted adolescence as a period of increased risk-taking, which is postulated to result from an overactive reward system in the brain. Longitudinal studies are pivotal for testing these brain-behavior relations because individual slopes are more sensitive for detecting change. The aim of the current study was twofold: (1) to test patterns of age-related change (i.e., linear, quadratic, and cubic) in activity in the nucleus accumbens, a key reward region in the brain, in relation to change in puberty (self-report and testosterone levels), laboratory risk-taking and self-reported risk-taking tendency; and (2) to test whether individual differences in pubertal development and risk-taking behavior were contributors to longitudinal change in nucleus accumbens activity. We included 299 human participants at the first time point and 254 participants at the second time point, ranging between ages 8-27 years, time points were separated by a 2 year interval. Neural responses to rewards, pubertal development (self-report and testosterone levels), laboratory risk-taking (balloon analog risk task; BART), and self-reported risk-taking tendency (Behavior Inhibition System/Behavior Activation System questionnaire) were collected at both time points. The longitudinal analyses confirmed the quadratic age pattern for nucleus accumbens activity to rewards (peaking in adolescence), and the same quadratic pattern was found for laboratory risk-taking (BART). Nucleus accumbens activity change was further related to change in testosterone and self-reported reward-sensitivity (BAS Drive). Thus, this longitudinal analysis provides new insight in risk-taking and reward sensitivity in adolescence: (1) confirming an adolescent peak in nucleus accumbens activity, and (2) underlining a critical role for pubertal hormones and individual differences in risk-taking tendency.

  3. The effect of a complex training and detraining programme on selected strength and power variables in early pubertal boys.

    Science.gov (United States)

    Ingle, Lee; Sleap, Mike; Tolfrey, Keith

    2006-09-01

    Complex training, a combination of resistance training and plyometrics is growing in popularity, despite limited support for its efficacy. In pre- and early pubertal children, the study of complex training has been limited, and to our knowledge an examination of its effect on anaerobic performance characteristics of the upper and lower body has not been undertaken. Furthermore, the effect of detraining after complex training requires clarification. The physical characteristics (mean+/-s) of the 54 male participants in the present study were as follows: age 12.3 +/- 0.3 years, height 1.57 +/- 0.07 m, body mass 50.3 +/- 11.0 kg. Participants were randomly assigned to an experimental (n = 33) or control group (n = 21). The training, which was performed three times a week for 12 weeks, included a combination of dynamic constant external resistance and plyometrics. After training, participants completed 12 weeks of detraining. At baseline, after training and after detraining, peak and mean anaerobic power, dynamic strength and athletic performance were assessed. Twenty-six participants completed the training and none reported any training-related injury. Complex training was associated with small increases ( 0.05). In the experimental group, dynamic strength was increased by 24.3 - 71.4% (dependent on muscle group; P 0.05). For 40-m sprint running, basketball chest pass and vertical jump test performance, the experimental group saw a small improvement ( 0.05). In conclusion, in pre- and early pubertal boys, upper and lower body complex training is a time-effective and safe training modality that confers small improvements in anaerobic power and jumping, throwing and sprinting performance, and marked improvements in dynamic strength. However, after detraining, the benefits of complex training are lost at similar rates to other training modalities.

  4. Differential selection on pollen and pistil traits in relation to pollen competition in the context of a sexual conflict over timing of stigma receptivity

    Science.gov (United States)

    Lankinen, Åsa; Strandh, Maria

    2016-01-01

    Sexual conflict and its evolutionary consequences are understudied in plants, but the theory of sexual conflict may help explain how selection generates and maintains variability. Here, we investigated selection on pollen and pistil traits when pollen arrives sequentially to partially receptive pistils in relation to pollen competition and a sexual conflict over timing of stigma receptivity in the mixed-mating annual Collinsia heterophylla (Plantaginaceae). In this species the conflict is generated by early fertilizing pollen that reduces seed production, which is counteracted by delaying receptivity in the recipient. We performed sequential two-donor pollinations at early floral developmental stages involving two pollen deposition schedules (with or without a time lag of 1 day), using only outcross or self and outcross pollen. We investigated pollen and pistil traits in relation to siring success (male fitness) and seed production (female fitness). In contrast to previous findings in receptive pistils in C. heterophylla and in other species, last arriving pollen donors showed highest siring success in partially receptive pistils. The last male advantage was weaker when self pollen was the first arriving donor. Two measures of germination rate (early and late) and pollen tube growth rate of first arriving donors were important for siring success in crosses with a time lag, while only late germination rate had an effect in contemporary crosses. Curiously, late stigma receptivity was negatively related to seed production in our contemporary crosses, which was opposite to expectation. Our results in combination with previous studies suggest that pollen and pistil traits in C. heterophylla are differentially advantageous depending on stage of floral development and varying pollen deposition schedules. Variation in success of these traits over floral development time may result from sexually antagonistic selection. PMID:27562796

  5. The Right Time and Place? Middle School Language Arts Teachers Talk about Not Talking about Sexual Orientation

    Science.gov (United States)

    Puchner, Laurel; Klein, Nicole Aydt

    2011-01-01

    In this article we report results of a qualitative interview study focusing on middle school Language Arts teachers' perceptions, attitudes, and reported practices related to LGBQ topics. The study found that virtually all of the teacher participants recognized that the topic of same-sex sexuality was important for their students, yet the teachers…

  6. Arthrospira (Spirulina) platensis supplementation affects folliculogenesis, progesterone and ghrelin levels in fattening pre-pubertal gilts

    NARCIS (Netherlands)

    Abadjieva, Desislava; Nedeva, Radka; Marchev, Yordan; Jordanova, Gergana; Chervenkov, Mihail; Dineva, Julieta; Shimkus, Almantas; Shimkiene, Aldona; Teerds, Katja; Kistanova, Elena

    2017-01-01

    The aim of the present investigation was to study the effect of Arthrospira (Spirulina) platensis supplemented diet on follicular development and related endocrine parameters, such as estradiol and progesterone levels as well as ghrelin levels in pre-pubertal gilts. Twenty-one 60-day-old Danube

  7. Sex Variations in Youth Anxiety Symptoms: Effects of Pubertal Development and Gender Role Orientation

    Science.gov (United States)

    Carter, Rona; Silverman, Wendy K.; Jaccard, James

    2011-01-01

    This study evaluated whether pubertal development and gender role orientation (i.e., masculinity and femininity) can partially explain sex variations in youth anxiety symptoms among clinic-referred anxious youth (N = 175; ages 9-13 years; 74% Hispanic; 48% female). Using youth and parent ratings of youth anxiety symptoms, structural equation…

  8. Pubertal Development, Choice of Friends, and Smoking Initiation among Adolescent Males

    Science.gov (United States)

    Drapela, Laurie A.; Gebelt, Janet L.; McRee, Nick

    2006-01-01

    Prior research has indicated that pubertal development and peer associations are important determinants of adolescent smoking behavior. However, more remains to be learned about "why" these variables matter or how they may be related to one another in ways that lead to the initiation of smoking. Using contractual data from the National…

  9. Sex Variations in Youth Anxiety Symptoms: Effects of Pubertal Development and Gender Role Orientation

    Science.gov (United States)

    Carter, Rona; Silverman, Wendy K.; Jaccard, James

    2011-01-01

    This study evaluated whether pubertal development and gender role orientation (i.e., masculinity and femininity) can partially explain sex variations in youth anxiety symptoms among clinic-referred anxious youth (N = 175; ages 9-13 years; 74% Hispanic; 48% female). Using youth and parent ratings of youth anxiety symptoms, structural equation…

  10. Effect of high and low antral follicle count in pubertal beef heifers on IVF

    Science.gov (United States)

    Pubertal heifers can be classified between those with high (n = 25) or low (n = 15) antral follicle counts (AFC). The objective of this study was to determine oocyte development and maturation (e.g. fertility) in an IVF system for high- and low-AFC heifers. From a pool of 120 heifers, 10 high- and 1...

  11. Brief Report: Fathers' and Mothers' Marital Relationship Predicts Daughters' Pubertal Development Two Years Later

    Science.gov (United States)

    Saxbe, Darby E.; Repetti, Rena L.

    2009-01-01

    Parents of 50 4th grade girls reported on their marital relationships and then, two years later, rated their daughters' pubertal development. Fathers' ratings of marital dissatisfaction, mothers' ratings of less emotional support from husbands, and both parents' ratings of aversive marital conflict were correlated with more advanced pubertal…

  12. Insulin resistance in obese pre-pubertal children: Relation to body composition

    Directory of Open Access Journals (Sweden)

    Heba Elsedfy

    2014-07-01

    Conclusion: Dysglycaemia and dyslipidaemia are common among pre-pubertal obese children. Insulin sensitivity indices based on OGTT are superior to fasting indices in identifying at risk children. OGTT should be included in assessing obese children with BMI > 2 SDS. DXA scanning has limited value for this purpose in clinical settings.

  13. Serum inhibin B concentrations in pubertal boys conceived by ICSI: first results

    NARCIS (Netherlands)

    F. Belva; M. Bonduelle; R.C. Painter; J. Schiettecatte; P. Devroey; J. de Schepper

    2010-01-01

    Currently, no published data exist about the gonadal function of children born after ICSI. To evaluate potential risk of testicular seminal dysfunction in boys born to fathers with compromised spermatogenesis, serum inhibin B (as a marker for spermatogenesis) was assessed. We recruited 50 pubertal a

  14. Salivary testosterone concentrations in pubertal ICSI boys compared with spontaneously conceived boys

    NARCIS (Netherlands)

    F. Belva; M. Bonduelle; J. Schiettecatte; H. Tournaye; R.C. Painter; P. Devroey; J. de Schepper

    2011-01-01

    BACKGROUND: To date, no data exist about Leydig cell function of pubertal boys born after ICSI. To evaluate a potential risk of gonadal dysfunction in children born from fathers with compromised fertility, testicular function was assessed by the measurement of salivary testosterone. METHODS: Morning

  15. Identification of various testicular cell populations in pubertal and adult cockerels

    Science.gov (United States)

    Precise identification of the male germinal stem cell population is important for their practical use in programs dedicated to the integration of exogenous genetic material in testicular tissues. In the present study, our aim was to identify germinal cell populations in the testes of pubertal and ad...

  16. Elevated serum IGF-I, but unaltered sex steroid levels, in healthy boys with pubertal gynaecomastia

    DEFF Research Database (Denmark)

    Mieritz, Mikkel G; Sorensen, Kaspar; Aksglaede, Lise

    2014-01-01

    of 501 healthy Danish school boys (aged 6·1-19·8 year) from the COPENHAGEN Puberty Study. MEASUREMENTS: Anthropometry and pubertal stages (PH1-6 and G1-5) were evaluated, and the presence of gynaecomastia was assessed. Body fat percentage was calculated by means of four skin folds and impedance...

  17. Serum AMH levels are lower in healthy boys who develop pubertal gynaecomastia

    DEFF Research Database (Denmark)

    Mieritz, Mikkel G.; Hagen, Casper P.; Almstrup, Kristian

    2015-01-01

    Background: Pubertal gynaecomastia is thought to be a clinical sign of an oestrogen-androgen imbalance, affecting up to 60% of boys. In most cases no underlying endocrinopathy can be identified. In boys, Anti-mullerian hormone (AMH) is produced by immature Sertoli cells and circulating level decr...

  18. Effects of vitamin A on in vitro maturation of pre-pubertal mouse spermatogonial stem cells.

    Directory of Open Access Journals (Sweden)

    Albanne Travers

    Full Text Available Testicular tissue cryopreservation is the only potential option for fertility preservation in pre-pubertal boys exposed to gonadotoxic treatment. Completion of spermatogenesis after in vitro maturation is one of the future uses of harvested testicular tissue. The purpose of the current study was to evaluate the effects of vitamin A on in vitro maturation of fresh and frozen-thawed mouse pre-pubertal spermatogonial stem cells in an organ culture system. Pre-pubertal CD1 mouse fresh testes were cultured for 7 (D7, 9 (D9 and 11 (D11 days using an organ culture system. Basal medium was supplemented with different concentrations of retinol (Re or retinoic acid (RA alone or in combination. Seminiferous tubule morphology (tubule diameter, intra-tubular cell type, intra-tubular cell death and proliferation (PCNA antibody and testosterone level were assessed at D7, D9 and D11. Pre-pubertal mouse testicular tissue were frozen after a soaking temperature performed at -7 °C, -8 °C or -9 °C and after thawing, were cultured for 9 days, using the culture medium preserving the best fresh tissue functionality. Retinoic acid at 10(-6M and retinol at 3.3.10(-7M, as well as retinol 10(-6M are favourable for seminiferous tubule growth, maintenance of intra-tubular cell proliferation and germ cell differentiation of fresh pre-pubertal mouse spermatogonia. Structural and functional integrity of frozen-thawed testicular tissue appeared to be well-preserved after soaking temperature at -8 °C, after 9 days of organotypic culture using 10(-6M retinol. RA and Re can control in vitro germ cell proliferation and differentiation. Re at a concentration of 10(-6M maintains intra-tubular cell proliferation and the ability of spermatogonia to initiate spermatogenesis in fresh and frozen pre-pubertal mouse testicular tissue using a soaking temperature at -8 °C. Our data suggested a possible human application for in vitro maturation of cryopreserved pre-pubertal testicular

  19. Sexual Dysfunction in Type 2 Diabetes at Diagnosis: Progression over Time and Drug and Non-Drug Correlated Factors

    Science.gov (United States)

    Corona, Giovanni; Giorda, Carlo B.; Cucinotta, Domenico; Guida, Piero; Nada, Elisa

    2016-01-01

    Aims To present the longitudinal data of the SUBITO-DE study, a prospective survey involving male patients with new or recently diagnosed type 2 diabetes mellitus (T2DM) (<24 months). Materials and Methods Sexual function was assessed in male patients with T2DM at baseline (phase 1) and after a mean follow-up of 18 months (phase 2). Standard metabolic parameters and sexual and depressive symptoms were evaluated. Results Six of the 499 enrolled patients died of different causes during phase 1. Of the 493 surviving men invited to participate in phase 2, 450 (mean age 59.0±9.0 years) (90.2%) accepted and 43 (8.2%) were lost to follow-up. As compared to baseline, the proportion of the men who reported improvement in erectile dysfunction (ED) at follow-up was nearly double that of the men who reported worsening of ED (22.6% vs. 12.8%). The increase in frequency of sexual activity the men reported at follow-up assessment indicates that many never treated before baseline were taking an ED drug during the study period (106 subjects). Phosphodiesterase type 5 inhibitors (PDE5i) were the ED drugs most commonly taken at both baseline and follow-up. An overall improvement over baseline values was observed in metabolic targets for T2DM and depressive symptoms. Conversely, no change in lifestyle behaviors was recorded during the study. Conclusions Sexual dysfunction is a major concern in men with T2DM. The SUBITO-DE study demonstrates that, when combined with adequate counseling and tailored PDE5i therapy, an integrated approach to achieving metabolic targets in men with T2DM can improve sexual function as well as depressive symptoms. PMID:27706160

  20. Associations between socio-demographic characteristics and pubertal status with disordered eating among primary school children in Selangor, Malaysia.

    Science.gov (United States)

    Chong, Lin Siew; Chin, Yit Siew; Gan, Wan Ying; Nasir, Mohd Taib Mohd

    2017-03-01

    To determine the associations between socio-demographic characteristics and pubertal status with disordered eating among primary school children. Using a stratified multi-stage sampling, a total of 816 children (282 boys and 534 girls) aged 10 to 11 years from 12 selected primary schools in the state of Selangor, participated in this study. Data were collected on socio-demographic characteristics, pubertal status and disordered eating behaviors. The Pubertal Development Scale and the Children's Eating Attitudes Test (ChEAT) were used to assess pubertal status and disordered eating, respectively. Logistic regression analysis was conducted to determine the risk factors of disordered eating. The prevalence of disordered eating was 30.8% (32.8% in boys and 29.7% in girls). However, the sex difference in the prevalence was not statistically significant. Age, ethnicity and pubertal status were significantly associated with disordered eating in univariate logistic regression analysis. Multivariate logistic regression analysis showed that among boys, being either in an advanced or post-pubertal stage (adjusted OR=8.64) and older age group (adjusted OR=2.03) were risk factors of disordered eating. However, among girls, being a Malay (adjusted OR=3.79) or Indian (adjusted OR=5.04) in an advanced or post-pubertal stage (adjusted OR=2.34) and older age group (adjusted OR=1.53) were risk factors of disordered eating. This study found one in three children had disordered eating. Since ethnicity and pubertal status were identified as risk factors, ethnicity-specific intervention programs on the prevention of disordered eating among children should take into consideration their pubertal status.

  1. Effect of pubertal development and physical activity on plasma ghrelin concentration in boys.

    Science.gov (United States)

    Jürimäe, J; Cicchella, A; Tillmann, V; Lätt, E; Haljaste, K; Purge, P; Pomerants, T; Jürimäe, T

    2009-01-01

    The aim of the present study was to assess the influence of regular physical activity on plasma ghrelin concentration in pre-pubertal and pubertal boys. In addition, the impact of ghrelin concentration on bone mineral density (BMD) was examined. In total, 56 healthy schoolboys aged between 10 and 16 yr were divided into the swimming (no.=28) and the control (no.=28) groups. The subjects were matched by age and body mass index (BMI), generating 9 matched pairs in pubertal group I (Tanner stage 1), 11 pairs in group II (Tanner stages 2 and 3), and 8 pairs in group III (Tanner stages 4 and 5). Swimmers in pubertal groups II and III had significantly (both pghrelin levels than the controls (group II: 1126.8+/-406.0 vs 868.3+/-411.2 pg/ml; group III: 1105.5+/-337.5 vs 850.8+/-306.0 pg/ml, respectively), whereas no difference was seen in the pubertal group I (1230.8+/-386.0 vs 1272.7+/-424.4 pg/ml). Ghrelin was the most important hormonal determinant for total BMD and lumbar apparent volumetric BMD (BMAD) (R2=27.2% and R2=19.8%, respectively) in swimmers, whereas in control boys, plasma IGF-I was the most important hormonal predictor accounting for 41.8% of the variability of total BMD and 20.4% of the variability of lumbar BMAD. In conclusion, ghrelin concentration decreased during puberty in physically inactive boys, while in regularly physically active boys it remained relatively unchanged. Ghrelin appears to be an important hormonal predictor for BMD in physically active boys, while BMD is mostly determined by IGF-I in physically inactive boys.

  2. Parathyroid hormone levels in pubertal uremic adolescents treated with growth hormone.

    Science.gov (United States)

    Picca, Stefano; Cappa, Marco; Martinez, Chiara; Moges, Seyoum Ido; Osborn, John; Perfumo, Francesco; Ardissino, Gianluigi; Bonaudo, Roberto; Montini, Giovanni; Rizzoni, Gianfranco

    2004-01-01

    We have previously described severe hyperparathyroidism during the pubertal growth spurt in three uremic adolescents treated with recombinant human growth hormone (rhGH). Here we investigate the possible role of puberty in the genesis of hyperparathyroidism during rhGH treatment of a large cohort of patients. Data from 67 uremic patients treated with rhGH from five Italian pediatric nephrology centers were retrospectively recorded every 3 months starting 1 year before rhGH administration. The mean (+/-SD) rhGH treatment observation period was 19.9+/-5.9 months. The mean age at the start of rhGH treatment was 8.3+/-3.6 years. Of the 67 patients, 15 reached pubertal stage 2 during the 1st year of rhGH treatment and 12 of these 15 progressed to pubertal stage 3. The relative increase in parathyroid hormone (PTH) levels after rhGH initiation was greater in pubertal [1.95, 95% confidence interval (CI) 1.43-2.66] than in prepubertal patients (1.19, 95% CI 1.01-1.40). Increases in PTH levels were significantly different between the two groups (Delta=1.64, 95% CI 1.16-3.19, P=0.007). Multiple regression analysis showed an inverse correlation between PTH and calcium levels and a positive correlation between PTH and pubertal stage 3. There was no correlation with phosphate levels and calcitriol dosage. In conclusion, these results suggest that in uremic adolescents treated with rhGH puberty may influence PTH levels.

  3. Infantile sexuality

    DEFF Research Database (Denmark)

    Zeuthen, Katrine Egede; Gammelgård, Judy

    2010-01-01

    When first presented, Freud´s theory of infantile sexuality was a scandal. Not only was the claim that the small child sucking at the mother´s breast experiences a kind of pleasure that Freud without hesitation named sexual, the theory also turned the common understanding of human sexuality up...... vision of the sexual. Following a historic outline, we examine the theories that inspired by Laplanche, once more discuss infantile sexuality, and argue that infantile sexuality is clarified by combining the concept of the drive with what in effect is an inter-subjective point of view....

  4. HIV prevalence and high-risk sexual behaviours among MSM repeat and first-time testers in China: implications for HIV prevention

    Directory of Open Access Journals (Sweden)

    Xue Bai

    2014-07-01

    Full Text Available Introduction: Little is known about HIV testing, HIV infection and sexual behaviour among bathhouse patrons in China. This study aims to assess differences in HIV prevalence and high-risk sexual behaviours between repeat and first-time testers among men who have sex with men (MSM attending bathhouse in Tianjin, China. Methods: Between March 2011 and September 2012, a HIV voluntary counselling and testing station was established in a gay bathhouse, which provided HIV testing and conducted a survey among participants recruited through snowball sampling. Differences in demographic and high-risk sexual behaviours between repeat and first-time testers were assessed using the chi-square test. Univariate and multivariate logistic regression analyses were conducted to identify predictors for HIV infection. Results: Of the 1642 respondents, 699 (42.6% were repeat testers and 943 (57.4% were first-time testers. Among repeat testers, a higher proportion were men aged 18 to 25, single, better educated, had a history of STIs and worked as male sex workers or “money boys” (MBs. Repeat testers were less likely to report having unprotected anal intercourse in the past six months. The overall HIV prevalence was 12.4% (203/1642. There was no difference in HIV prevalence between repeat (11.2%, 78/699 and first-time (13.3%, 125/943 testers. The HIV prevalence increased with age among first-time testers (χ 2 trend=9.816, p=0.002. First-time MB testers had the highest HIV prevalence of 34.5%. Conclusions: MSM attending bathhouse had an alarmingly high HIV infection rate, particularly in MB. Targeted interventions are urgently needed especially focusing on older MSM and MBs.

  5. Deleterious effects of obesity on physical fitness in pre-pubertal children.

    Science.gov (United States)

    Ceschia, Arianna; Giacomini, Stefano; Santarossa, Simone; Rugo, Miriam; Salvadego, Desy; Da Ponte, Alessandro; Driussi, Caterina; Mihaleje, Martina; Poser, Stefano; Lazzer, Stefano

    2016-01-01

    The prevalence of obesity in children has increased dramatically during the past decades in Europe and understanding physical fitness and its components in children is critical to design and implement effective interventions. The objective of the present study was to analyse the association between physical fitness (aerobic, speed, agility, power, flexibility and balance) and body mass index (BMI) in pre-pubertal children. A total of 2411 healthy schoolchildren (7-11 years) participated in this study. Anthropometric characteristics and body composition were assessed by skinfold thickness. Physical fitness was measured by nine physical fitness tests: endurance running, 20 m running speed, agility, handgrip strength, standing long jump and squat jump, sit and reach, medicine ball forward throw and static balance. No relevant differences were observed between boys and girls regarding anthropometric characteristics, body composition and physical fitness. However, overweight and obese children showed significantly lower physical fitness levels in endurance running, speed and agility (mean: +18.8, +5.5 and +14.5% of time to complete tasks, respectively), lower limb power normalised to body mass (-23.3%) and balance tests (number of falls: +165.5%) than their normal weight counterparts. On the other hand, obesity did not affect handgrip, throwing and flexibility. In conclusion, increased BMI was associated with lower performance capabilities limiting proper motor skill development, which directly affects the ability of children to take on sports skills. Actions undertaken to promote children's wellness and fitness should be prioritised and introduced early in life with the aim of enhancing physical fitness as well as preventing overweight and obesity.

  6. Epididymis of Viscacha (Lagostomus maximus maximus): A Morphological Comparative Study in Relation to Sexual Maturity.

    Science.gov (United States)

    Cruceño, A A M; Aguilera-Merlo, C I; Chaves, E M; Mohamed, F H

    2017-02-01

    The morphological variations and the androgen receptor (AR) expression were studied in viscacha epididymis in relation to sexual maturity. The animals were divided into immature, pre-pubertal and adult, according to their corporal weight and testicular histology. The epididymides were studied by light microscopy, immunohistochemistry for AR and morphometric analysis. In pre-pubertal and adult animals, four well-differentiated segments (initial, caput, corpus and cauda) were observed, while in immature animals, three segments were identified (initial-caput segment, corpus and cauda). In each segment, the structural parameters and the relative cell distribution were different between the groups. The serum testosterone levels of pre-pubertal and adults showed a very significant increase related to sexual maturity. The AR expression in epithelial and fibromuscular stromal cells was different between the groups. In conclusion, the present work demonstrates that the morphological characteristics of the viscacha epididymis vary while sexual maturity is reached, the development of initial and caput is subsequent to corpus and cauda development and the androgens might play an important role during this process.

  7. Sexuality of dissocial persons

    Directory of Open Access Journals (Sweden)

    Marta Janus

    2016-02-01

    Full Text Available Introduction. The development of personality disorders as well as sexual disorders is defined by the common time spectrum as well as deficits and changes in such areas as biological, environmental and mental area. Dissocial (antisocial personality disorder is characterised by a pervasive pattern of disregard for, or violation of, the rights of others. The indices of the discussed disorder can be found in specific patterns of social inadequacy occurring during childhood and puberty. At the same time, characteristic indices of social functioning at a young age often indicate subsequent dysfunctions in the area of sexuality. Aim. The aim of this paper is to explain sexual functioning of persons with dissocial personality disorder (including the relation with sexual dysfunctions, and to ascertain issues that need further empirical studies. Method. As a result of analysis of available literature (matched with EBSCO database search fulfilling criteria of sample size, accuracy of examination procedure, conclusions and discussion 5 articles fulfilling criteria cited above has been found. Conclusions: Based on literature overview, it appeared to be impossible to determine one coherent way of sexual functioning of dissocial persons, and to establish causal relationship of sexual dysfunctions and dissocial personality disorder. However, it is possible to indicate group of most characteristic dysfunctional sexual behaviours. Noteworthy, available publication analyse only selected aspects of sexual behaviours in small, homogenous groups. There is a lack of review studies as well as multi-faceted studies.

  8. Different Patterns of Sexual Identity Development over Time: Implications for the Psychological Adjustment of Lesbian, Gay, and Bisexual Youths

    OpenAIRE

    Rosario, Margaret; Schrimshaw, Eric W.; Hunter, Joyce

    2011-01-01

    Despite research documenting variability in the sexual identity development of lesbian, gay, and bisexual (LGB) youths, it remains unclear whether different developmental patterns have implications for the psychological adjustment of LGB youths. The current report longitudinally examines whether different patterns of LGB identity formation and integration are associated with indicators of psychological adjustment among an ethnically diverse sample of 156 LGB youths (ages 14 – 21) in New York ...

  9. Does the timing of attainment of maturity influence sexual size dimorphism and adult sex ratio in turtles?

    Science.gov (United States)

    Lovich, Jeffrey E.; Gibbons, J. Whitfield; Agha, Mickey

    2014-01-01

    The attainment of sexual maturity has been shown to affect measures of sexual size dimorphism (SSD) and adult sex ratios in several groups of vertebrates. Using data for turtles, we tested the model that sex ratios are expected to be male-biased when females are larger than males and female-biased when males are larger than females because of the relationship of each with the attainment of maturity. Our model is based on the premise that the earlier-maturing sex remains smaller, on average throughout life, and predominates numerically unless the sexes are strongly affected by differential mortality, differential emigration, and immigration, or biased primary sex ratios. Based on data for 24 species in seven families, SSD and sex ratios were significantly negatively correlated for most analyses, even after the effect of phylogenetic bias was removed. The analyses provide support for the model that SSD and adult sex ratios are correlated in turtles as a result of simultaneous correlation of each with sexual differences in attainment of maturity (bimaturism). Environmental sex determination provides a possible mechanism for the phenomenon in turtles and some other organisms.

  10. Adolescent Sexuality.

    Science.gov (United States)

    Sharpe, Thomasina H.

    2003-01-01

    This article offers a medical and psychosocial perspective of adolescent sexual development. Sub-types of sexual development are discussed as well as treatment implications for allied health providers. (Contains 38 references.) (Author)

  11. Sexual Violence

    Science.gov (United States)

    Sexual Violence Facts at a Glance 2012 Adults In a nationally representative survey of adults: 1 • Nearly ... men (5.6% and 5.3%, respectively) experienced sexual violence other than rape, such as being made ...

  12. Sexual Health

    Science.gov (United States)

    ... big part of being human. Love, affection and sexual intimacy all play a role in healthy relationships. ... both men and women. Factors that can affect sexual health include Fear of unplanned pregnancy Concerns about ...

  13. Female sexuality

    OpenAIRE

    Rao, T.S. Sathyanarana; Nagaraj, Anil Kumar M.

    2015-01-01

    Sex is a motive force bringing a man and a woman into intimate contact. Sexuality is a central aspect of being human throughout life and encompasses sex, gender identities and roles, sexual orientation, eroticism, pleasure, intimacy, and reproduction. Sexuality is experienced and expressed in thoughts, fantasies, desires, beliefs, attitudes, values, behaviors, practices, roles and relationships. Though generally, women are sexually active during adolescence, they reach their peak orgasmic fre...

  14. Sexual Harassment at Work: A European Experience

    Directory of Open Access Journals (Sweden)

    Artan Çela

    2015-03-01

    Full Text Available Unwelcome sexual advances, proposition or pressure for sexual activity, offensive flirtations, leering, whistling, making sexually suggestive gestures, sexual jokes, unwanted sexual looks, unwanted letters, telephone call, or materials of a sexual nature, unwanted physical contact, actual or attempting rape or sexual assault, this and more of this conduct if took place in the workplace would amount to a sexual harassment. The sexual harassment at work has become a serious issue of our time. It is an unjustified interference of integrity, dignity and well-being of workers, causing problems from headaches to depression, loss of confidence, panic attacks and perhaps suicide as the only way appearing to be the sole possible relief from the unremitting and frightening behavior. This article presents information concerning the sexual harassment at workplace, covering topics such as, the definitions for sexual harassment in both international and national context, a short history of sexual harassment, types of sexual harassment, effect of sexual harassment, measure to combat and prevent sexual harassment. It offers a short overview in sexual harassment legislation of some industrialized EU Member States and the legal remedies available against sexual harassment. The main purpose of this article is to provide a better understanding and prevention concerning the issue of sexual harassment in workplace.

  15. Associations between youth homelessness, sexual offenses, sexual victimization, and sexual risk behaviors: a systematic literature review.

    Science.gov (United States)

    Heerde, Jessica A; Scholes-Balog, Kirsty E; Hemphill, Sheryl A

    2015-01-01

    Homeless youth commonly report engaging in sexual risk behaviors. These vulnerable young people also frequently report being sexually victimized. This systematic review collates, summarizes, and appraises published studies of youth investigating relationships between homelessness, perpetration of sexual offenses, experience of sexual victimization, and engagement in sexual risk behavior. A systematic search of seventeen psychology, health, and social science electronic databases was conducted. Search terms included "homeless*," "youth," "offend*," "victimization," "crime," "rape," "victim*," and "sex crimes." Thirty-eight studies were identified that met the inclusion criteria. Findings showed homeless youth commonly report being raped and sexually assaulted, fear being sexually victimized, and engage in street prostitution and survival sex. Rates of victimization and sexual risk behavior were generally higher for females. Given the paucity of longitudinal studies and limitations of current studies, it is unclear whether homelessness is prospectively associated with sexual victimization or engagement in sexual risk behavior, and whether such associations vary cross nationally and as a function of time and place. Future prospective research examining the influence of the situational context of homelessness is necessary to develop a better understanding of how homelessness influences the perpetration of sexual offenses, experience of sexual victimization, and engagement in sexual risk behavior among homeless youth.

  16. Healthy Sexuality

    Science.gov (United States)

    ... it is not merely the absence of disease, dysfunction, or infirmity. Sexual health requires a positive and respectful approach to ... women’s response intertwines both her physical and emotional sexual drive. This would explain how women can start, or be receptive to, a sexual ...

  17. Sexual Regret

    Directory of Open Access Journals (Sweden)

    Leif Edward Ottesen Kennair

    2016-12-01

    Full Text Available The current study sought to answer three key questions about explaining the emotion of regret in the domain of casual sex: Are sex differences in sexual regret robust or attenuated in a highly egalitarian culture? What proximate psychological variables might explain sex differences in sexual regret? And what accounts for within-sex variation in experiences of sexual regret about casual sex. We conducted a study of 263 Norwegian students (ages 19–37 who reported how much they regretted having either engaged in, or passed up, their most recent casual sexual experience. Sex differences in sexual regret are not attenuated in this sexually egalitarian culture. The study revealed sex differences in worries about pregnancy, STIs, and reputation; however, these predictors did not succeed in accounting for the sex differences in regret engaging in casual sex. Sexual gratification and socio-sexual orientation both predicted the sex differences in casual sex regret. In contrast, only socio-sexual orientation attenuated the sex difference in regret passing up casual sex. Predictors of within-sex variation in casual sexual regret included worry about sexual reputation, experienced gratification during the encounter, and socio-sexual orientation. Discussion focuses on implications for the psychological design features of this relatively neglected emotion.

  18. Infantile sexuality

    DEFF Research Database (Denmark)

    Zeuthen, Katrine Egede; Gammelgård, Judy

    2010-01-01

    When first presented, Freud´s theory of infantile sexuality was a scandal. Not only was the claim that the small child sucking at the mother´s breast experiences a kind of pleasure that Freud without hesitation named sexual, the theory also turned the common understanding of human sexuality up-si...

  19. Sexual Assault

    Science.gov (United States)

    Sexual assault is any sexual activity to which you haven't freely given your consent. This includes completed or attempted sex acts that are against ... is unable to consent. It also includes abusive sexual contact. It can happen to men, women or ...

  20. Sexual Orientation (For Parents)

    Science.gov (United States)

    ... to reconcile their teen's sexual orientation with their religious or personal beliefs. Sadly, some react with anger, hostility, or rejection. But many parents find that they just need time to adjust ...

  1. Evaluating the Effectiveness of Pubertal Preparedness Program in Terms of Knowledge and Attitude Regarding Pubertal Changes Among Pre-Adolescent Girls

    Directory of Open Access Journals (Sweden)

    Manisha Rani RN

    2016-12-01

    Full Text Available Objective: To compare the knowledge and attitude regarding pubertal changes among pre – adolescent girls before and after the pubertal preparedness program (PPP in experimental and comparison group.Materials and methods: A Quasi experimental (non- equivalent comparison group pretest posttest design was adopted with 104pre-adolescentgirls (52 in each experimental and comparison group of age 12-14years, selected by purposive sampling from two different Government schools of Ambala District. Knowledge and attitude was assessed using structured knowledge questionnaire (KR-20 = 0.74 and 5 point likert scale (Cronbach’s alpha = 0.79 respectively. On the same day of pretest, PPP was administered and on 12th day FAQs reinforcement session was held only for experimental group. After 28 days, posttest was taken.Results: The computed t value of pretest of knowledge and attitude scores of pre-adolescent girls (1.97, (1.95 respectively in experimental and comparison group was found non-significant at 0.05 level of significance which shows that both group didn’t differ significantly in their knowledge and attitude before the administration of intervention. Findings of unpaired ‘t’ value of posttest knowledge and attitude scores of pre-adolescent girls (19.77, (17.17 respectively in experimental and comparison group were found significant at 0.05 level of significance, Thus knowledge and attitude of pre-adolescent girls were improved with PPP and FAQs session.Conclusion: Pubertal preparedness program and FAQs reinforcement session are effective in enhancing knowledge and developing favorable attitude among pre-adolescent girls.

  2. Child sexual abuse.

    Science.gov (United States)

    Hymel, K P; Jenny, C

    1997-08-01

    Multiple obstacles can hinder the medical evaluation of suspected child sexual abuse in pediatric primary care. The need for diagnostic accuracy is high. Knowledge of sexual abuse risk factors, an understanding of the victimization process, and awareness of the varied clinical presentations of sexual abuse can be of assistance. Open-ended questioning of the suspected victim is the most critical component of the evaluation. Skillful medical interviewing requires time, training, patience, and practice. Pediatricians lacking any of these four requirements should defer interviewing in sexual abuse cases to other professionals. Abnormal physical findings from sexual abuse are uncommon. Colposcopy has assisted pediatricians greatly in reaching consensus regarding diagnostic physical findings. Cases of acute sexual assault require familiarity with the forensic rape examination, STD screening and prophylaxis, and pregnancy prevention. Victimization from sexual abuse continues long after the abusive acts end, often requiring long-term therapeutic intervention. An emerging standard of care for medical evaluations of suspected child sexual abuse recognizes the requirement for patience and compassion while retaining objectivity. The pediatrician's primary concern must be for the child's physical and emotional well-being.

  3. Association of Sexual Maturation and Body Size of Arfak Children

    Directory of Open Access Journals (Sweden)

    ELDA IRMA JEANNE JOICE KAWULUR

    2012-09-01

    Full Text Available Gonad maturation in pubertal girls and boys is accompanied with somatic growth spurt, changes in quantity and distribution of body fat (BF, development of secondary sex characters, and relevant physiological events. Menarche (first event of menstruation and spermarche (first event of nocturnal sperm emission are usually used as indicators of gonad maturation. We found that median age at menarche of Arfak girls in Manokwari, West Papua is 12.2 years, while median age at spermarche of boys is 13.6 years. A possible factor causing young age at menarche is due to adaptation to unstable environmental conditions because of high risk of mortality by malaria disease during childhood. The events of menarche and spermarche achieved one year after the peak body height (BH velocity, and just before or at the same time with the time of maximum growth rate of body weight (BW, body mass index (BMI, and BF. The average BMI of Arfak girls was big at 21.9 kg/m2 at the time of their menarche. Bigger average BMI might be caused by prepubertal slowing down of BH growth compare to growth of BW whichis still increasing. Girls accumulate BF before puberty to be used as an energy reserve for the occurrence of menarche. At the time of development of secondary sexual characters girls use the fat reserve so it decline sharply after puberty. In boys, growth rate of BF was stopped at 11 years old, and then growing negatively presumably because boys use fat mass for the occurence of spemarche. BF growth rate reached the lowest point at the age 16 years old, and then increase linearly with age through adolescence until adulthood at age 23 years old.

  4. Retrospective cohort study of relationship between pubertal growth spurt and body mass index%围青春期体脂与青春发动时相关系的回顾性队列研究

    Institute of Scientific and Technical Information of China (English)

    张珊; 史慧静; 杨鞭; 张越

    2011-01-01

    Objective To examine peri-pubertal body mass index ( BMI) in relation to pubertal timing, as asseased by age at onset of pubertal growth spurt ( AOGS) and at peak height velocity ( APHV ), among children and adolescents. Methods A cluster sample of 329 nine-grade students was selected from 3 schools in Shanghai. For each subject, annual measurements of height and weight from grade one to grade nine were obtained from school health record. Age at OGS and PHV, criterion for pubertal timing, were calculated by using the cubic spline fit function. Results Advanced pubertal growth spurt was estimated by using P67 of peak height velocity of pubertal growth. BMI -Z score at pre-puberty, early puberty,and middle/late puberty were analyzed in relation to pubertal timing. The increments of BMI - Z score during pre-puberty to early puberty and during early to middle/late puberty were compared between advanced and non-advanced pubertal timing groups. Results In both of girls and boys, advanced growth spurt was associated with higher BMI -Z scores in pre-puberty, early puberty and middle/late puberty. Advanced growth spurt was significantly associated with greater increment of BMI -Z scores during pre-puberty to early puberty, which is not found in boys. Conclusion Higher level of BMI in pre-puberty and greater increments of BMI - Z score during pre-puberty to early puberty may predict advance growth spurt in adolescence as well as adulthood.%目的 研究不同青春发动时相的儿童青少年在围青春期的体脂水平及增长模式,为青春发动机制的研究和肥胖防控工作提供依据.方法 整群选择上海市3所学校的329名九年级学生,回溯一~九年级时的身高和体重体检记录,用Cubic Spline Fit函数拟合得到身高突增启动年龄和身高突增高峰年龄,并以此为青春发动时相界定的依据,分析围青春期不同阶段体质量指数(BMI)-Z值和BMI-Z增加值与青春发动时相的关系.结果 女生青春发

  5. Facing changes and changing faces in adolescence: a new model for investigating adolescent-specific interactions between pubertal, brain and behavioral development.

    Science.gov (United States)

    Scherf, K Suzanne; Behrmann, Marlene; Dahl, Ronald E

    2012-04-01

    Adolescence is a time of dramatic physical, cognitive, emotional, and social changes as well as a time for the development of many social-emotional problems. These characteristics raise compelling questions about accompanying neural changes that are unique to this period of development. Here, we propose that studying adolescent-specific changes in face processing and its underlying neural circuitry provides an ideal model for addressing these questions. We also use this model to formulate new hypotheses. Specifically, pubertal hormones are likely to increase motivation to master new peer-oriented developmental tasks, which will in turn, instigate the emergence of new social/affective components of face processing. We also predict that pubertal hormones have a fundamental impact on the re-organization of neural circuitry supporting face processing and propose, in particular, that, the functional connectivity, or temporal synchrony, between regions of the face-processing network will change with the emergence of these new components of face processing in adolescence. Finally, we show how this approach will help reveal why adolescence may be a period of vulnerability in brain development and suggest how it could lead to prevention and intervention strategies that facilitate more adaptive functional interactions between regions within the broader social information processing network. Copyright © 2011 Elsevier Ltd. All rights reserved.

  6. Sexual excitement.

    Science.gov (United States)

    Stoller, R J

    1976-08-01

    Sexual excitement depends on a scenario the person to be aroused has been writing since childhood. The story is an adventure, an autobiography disguised as fiction, in which the hero/heroine hides crucial intrapsychic conflicts, mysteries, screen memories of actual traumatic events and the resolution of these elements into a happy ending, best celebrated by orgasm. The function of the fantasy is to take these painful experiences and convert them to pleasure-triumph. In order to sharpen excitement-the vibration between the fear of original traumas repeating and the hope of a pleasurable conclusion this time-one introduces into the story elements of risk (approximations of the trauma) meant to prevent boredom and safety factors (sub-limnal signals to the storyteller that the risk are not truly dangerous). Sexual fantasy can be studied by means of a person's daydreams (including those chosen in magazines, books, plays, television, movies, and outright pornography), masturbatory behavior, object choice, foreplay, techniques of intercourse, or postcoital behavior.

  7. The Developmental Association of Sexual Self-Concept with Sexual Behavior among Adolescent Women

    Science.gov (United States)

    Hensel, Devon J.; Fortenberry, J. Dennis; O’Sullivan, Lucia F.; Orr, Donald P.

    2013-01-01

    Developing a sexual self-concept is an important developmental task of adolescence; however, little empirical evidence describes this development, nor how these changes are related to development in sexual behavior. Using longitudinal cohort data from adolescent women, we invoked latent growth curve analysis to: (1) examine reciprocal development in sexual self-concept (sexual openness, sexual esteem and sexual anxiety) over a four year time frame; (2) describe the relationship of these trajectories with changes in sexual behavior. We found significant transactional effects between these dimensions and behavior: sexual self-concept evolved during adolescence in a manner consistent with less reserve, less anxiety and greater personal comfort with sexuality and sexual behavior. Moreover, we found that sexual self-concept results from sexual behavior, as well as regulates future behavior. PMID:20970178

  8. The developmental association of sexual self-concept with sexual behavior among adolescent women.

    Science.gov (United States)

    Hensel, Devon J; Fortenberry, J Dennis; O'Sullivan, Lucia F; Orr, Donald P

    2011-08-01

    Developing a sexual self-concept is an important developmental task of adolescence; however, little empirical evidence describes this development, nor how these changes are related to development in sexual behavior. Using longitudinal cohort data from adolescent women, we invoked latent growth curve analysis to: (1) examine reciprocal development in sexual self-concept (sexual openness, sexual esteem and sexual anxiety) over a four year time frame; (2) describe the relationship of these trajectories with changes in sexual behavior. We found significant transactional effects between these dimensions and behavior: sexual self-concept evolved during adolescence in a manner consistent with less reserve, less anxiety and greater personal comfort with sexuality and sexual behavior. Moreover, we found that sexual self-concept results from sexual behavior, as well as regulates future behavior. Copyright © 2010 The Foundation for Professionals in Services for Adolescents. Published by Elsevier Ltd. All rights reserved.

  9. [Emergency contraception: efficacy difference between levonorgestrel and ulipristal acetate depending on the follicular size at the time of an unprotected sexual intercourse].

    Science.gov (United States)

    Jamin, C

    2015-03-01

    The most used treatment in the world for emergency contraception is the levonorgestrel (LNG) pill. However, its efficacy decreases if it is administered 3 days after unprotected sexual intercourse, whereas the ulipristal acetate (UPA) pill is effective up until 5 days afterwards. Pooled clinical data show that UPA is more effective than LNG when taken very shortly after intercourse (within 24h) or, conversely, between 72 and 120 h after intercourse. UPA is also more effective than LNG in inhibiting follicular rupture when administered near the time of ovulation. We show here why overall UPA is more effective than LNG in reducing the rate of unwanted pregnancies by demonstrating the effect of each product depending on the follicular size at the time of an unprotected sexual intercourse We also explain the difference between UPA and LNG in the maximum time to administration simply by the shift in ovulation and the fact that UPA has an effect on larger follicles than LNG does (18 mm vs. 14 mm), without postulating a hypothetical endometrial effect. We also explain why UPA and LNG remain emergency contraceptives and should not be used for daily contraception.

  10. Pubertal Onset in Girls is Strongly Influenced by Genetic Variation Affecting FSH Action

    Science.gov (United States)

    Hagen, Casper P.; Sørensen, Kaspar; Aksglaede, Lise; Mouritsen, Annette; Mieritz, Mikkel G.; Tinggaard, Jeanette; Wohlfart-Veje, Christine; Petersen, Jørgen Holm; Main, Katharina M.; Meyts, Ewa Rajpert-De; Almstrup, Kristian; Juul, Anders

    2014-01-01

    Age at pubertal onset varies substantially in healthy girls. Although genetic factors are responsible for more than half of the phenotypic variation, only a small part has been attributed to specific genetic polymorphisms identified so far. Follicle-stimulating hormone (FSH) stimulates ovarian follicle maturation and estradiol synthesis which is responsible for breast development. We assessed the effect of three polymorphisms influencing FSH action on age at breast deveopment in a population-based cohort of 964 healthy girls. Girls homozygous for FSHR -29AA (reduced FSH receptor expression) entered puberty 7.4 (2.5–12.4) months later than carriers of the common variants FSHR -29GG+GA, p = 0.003. To our knowledge, this is the strongest genetic effect on age at pubertal onset in girls published to date. PMID:25231187

  11. Giant fibroadenoma of the breast in a pre-pubertal girl: a case report

    Directory of Open Access Journals (Sweden)

    Sunder Goyal

    2014-02-01

    Full Text Available Juvenile fibroadenoma comprises about 4% of the total fibroadenomas. The incidence of giant juvenile fibroadenomas is merely 0.5% of all the fibroadenomas. Bilateral giant juvenile fibroadenomas are extremely rare. We are presenting a case of giant juvenile fibroadenomas in an 11-year-old pre-pubertal girl. The diagnosis was made on fine-needle aspiration cytology which was confirmed on histopathology. As these tumors are mostly benign, breast-conserving surgery is done so that patient can lead a normal life without psychological trauma.-----------------------------------Cite this article as: Goyal S, Garg G, Narang S. Giant fibroadenoma of the breast in a pre-pubertal girl: a case report. Int J Cancer Ther Oncol 2014; 2(1:020113.DOI: http://dx.doi.org/10.14319/ijcto.0201.13

  12. Pubertal Progression and Reproductive Hormones in Healthy Girls With Transient Thelarche

    DEFF Research Database (Denmark)

    Johansen, Marie Lindhardt; Hagen, Casper P.; Mieritz, Mikkel G.

    2017-01-01

    Context: Detailed evaluation of pubertal progression in girls from longitudinal studies is sparse, and the phenomenon of transient thelarche (TT), defined as the appearance, regression, and subsequent reappearance of breast buds, in healthy girls remains undescribed. Objective: To describe TT...... girls) followed longitudinally as part of the COPENHAGEN Puberty Study were included in the evaluation of TT. A total of 1466 girls from 2 cross-sectional studies were included in the creation of the puberty nomograms. Intervention(s): None. Main Outcome Measure(s): Pubertal progression, specifically...... thelarche, reproductive hormones, genotype, and growth. Results: Twelve of 98 (12%) girls experienced TT. A larger proportion of girls with TT entered puberty by the pubarche pathway (50%) compared with girls with normal progression (15.4%), P = 0.014. Girls with TT progressed through puberty normally when...

  13. Impact of socio-emotional context, brain development, and pubertal maturation on adolescent risk-taking.

    Science.gov (United States)

    Smith, Ashley R; Chein, Jason; Steinberg, Laurence

    2013-07-01

    While there is little doubt that risk-taking is generally more prevalent during adolescence than before or after, the underlying causes of this pattern of age differences have long been investigated and debated. One longstanding popular notion is the belief that risky and reckless behavior in adolescence is tied to the hormonal changes of puberty. However, the interactions between pubertal maturation and adolescent decision making remain largely understudied. In the current review, we discuss changes in decision making during adolescence, focusing on the asynchronous development of the affective, reward-focused processing system and the deliberative, reasoned processing system. As discussed, differential maturation in the structure and function of brain systems associated with these systems leaves adolescents particularly vulnerable to socio-emotional influences and risk-taking behaviors. We argue that this asynchrony may be partially linked to pubertal influences on development and specifically on the maturation of the affective, reward-focused processing system.

  14. Minor sperm abnormalities in young male post-pubertal patients with juvenile dermatomyositis

    Directory of Open Access Journals (Sweden)

    A.J.P. Moraes

    2008-12-01

    Full Text Available The objective of the present study was to identify sperm abnormalities in young male patients with juvenile dermatomyositis (JDM. In 2005, 18 male JDM patients, diagnosed according to the criteria of Bohan and Peter, were followed at the Pediatric Rheumatology Unit and Rheumatology Division, of our Institution. Of the 18 males, 11 were pre-pubertal and 7 were post-pubertal. Two of 7 post-pubertal JDM male patients were excluded: one for orchidopexy for cryptorchidism and the other for testicular ectopia in the left testis. The remaining 5 post-pubertal JDM patients were prospectively evaluated on the basis of two semen analyses, according to the World Health Organization (WHO, urologic evaluation, testicular Doppler ultrasound hormone profile. The data of the JDM patients were compared with those of 5 age-matched healthy controls. The median age 18, was similar in JDM patients and controls. All JDM patients had teratozoospermia (abnormal sperm morphology, as did 4 (80% of the controls. One of JDM patients had previous oligoasthenoteratozoospermia treated with intravenous cyclophosphamide with normalization of the number and concentration of the sperm after 5 years. All sperm parameters (sperm concentration, total sperm count and total motile sperm count by WHO, and sperm morphology by Kruger strict criteria, testicular volumes by Prader orchidometer and ultrasound, and hormones were similar in JDM patients compared with controls. The frequency of anti-sperm antibodies was similar in both groups. All JDM patients had minor sperm abnormalities in the head, midpiece, and/or tail of spermatozoids. Serial semen analyses in larger study populations are necessary to identify the extent and duration of sperm abnormalities in male patients with idiopathic inflammatory myopathies.

  15. Association of body mass index with lung function in pre- pubertal girls in Vadodara District

    Directory of Open Access Journals (Sweden)

    Rajeshri K Bodat

    2015-09-01

    Full Text Available Introduction: Among the various investigations available, pulmonary function test (PFT is a one of the important tool for the assessment of pulmonary function. There must be differences in reference values in India between different state, different region for spirometric parameters. Methodology: The present study was conducted among normal healthy pre pubertal girl in Vadodara region. The study was conducted among pre pubertal girls (10-12 yrs. Standard anthropometric measurements weight (kg, height (cm, was measured in a beam balance. Minimum three readings were given and best of the three was chosen for analysis, based on standardization of spirometry study based on ATS/ERS task force series and various other studies. Results: Mean age of the participants was 11.36 (+/-0.69 years. Similarly mean height, weight, BMI and BSA was 134.8(+/-8.91 cm, 28(+/-5.9 kg, 15.29(+/-2.02 (Kg/m2, and 1.02(+/-0.13 (m2 respectively. There were 27(60 % participants with BMI 18. There was significant statistical association between BMI and FEV1 (%, FEV1/FVC (%, PEFR (% (P < 0.05. Conclusion: There is significant relation between pulmonary function and BMI in pre pubertal girls. As BMI increase lung function tends to be decrease as compared to those who have low BMI. [Natl J Med Res 2015; 5(3.000: 256-258

  16. Pre-pubertal males practising Taekwondo exhibit favourable postural and neuromuscular performance.

    Science.gov (United States)

    Jlid, Mohamed Chedly; Maffulli, Nicola; Souissi, Nisar; Chelly, Mohamed Souheil; Paillard, Thierry

    2016-01-01

    The postural and neuromuscular performances in healthy children taekwondo (TKD) practitioners in comparison with control children were examined. Seventeen healthy pre-pubertal males undertaking only physical education at school (age: 11.88 ± 0.33 years) and 12 pre-pubertal male TKD practitioners (>3 years, 4 sessions a week) (age 11.66 ± 0.49 years) were recruited. Performances in the dynamic postural control (Star Excursion Balance Test -SEBT), vertical jump [squat jump (SJ) and countermovement jump (CMJ)] and sprint running (distances: 5, 10, 20 and 30 m) tests were compared between the two groups. The performances of the TKD practitioners were better than those of the non-TKD active for the SEBT (for 14 of 16 conditions, p  0.05). TKD practice would stimulate sensory input and motor output of the postural system that would enhance its efficiency. In addition, the dynamic nature of TKD would develop the muscle power of the lower limbs. In our sample of healthy pre-pubertal males, TKD appears to improve postural and neuromuscular functions, but further research is required.

  17. Mutational Analysis of TAC3 and TACR3 Genes in Patients with Idiopathic Central Pubertal Disorders

    Science.gov (United States)

    Tusset, Cintia; Noel, Sekoni D.; Trarbach, Ericka B.; Silveira, Letícia F. G.; Jorge, Alexander A. L.; Brito, Vinicius N.; Cukier, Priscila; Seminara, Stephanie B.; de Mendonça, Berenice B.; Kaiser, Ursula B.; Latronico, Ana Claudia

    2013-01-01

    Aim To investigate the presence of variants in the TAC3 and TACR3 genes, which encode NKB and its receptor (NK3R), respectively, in a large cohort of patients with idiopathic central pubertal disorders. Patients and Methods Two hundred and thirty seven patients were studied: 114 with central precocious puberty (CPP), 73 with normosmic isolated hypogonadotropic hypogonadism (IHH) and 50 with constitutional delay of growth and puberty (CDGP). The control group consisted of 150 Brazilian individuals with normal pubertal development. Genomic DNA was extracted from peripheral blood and the entire coding region of both TAC3 and TACR3 genes were amplified and automatically sequenced. Results We identified one variant (p.A63P) in NKB and four variants, p.G18D, p.L58L (c.172C>T), p.W275* and p.A449S in NK3R, which were absent in the control group. The p.A63P variant was identified in a girl with CPP, and p.A449S in a girl with CDGP. The known p.G18D, p.L58L and p.W275* variants were identified in three unrelated males with normosmic IHH. Conclusion Rare variants in the TAC3 and TACR3 genes were identified in patients with central pubertal disorders. Loss-of-function variants of TACR3 were associated with the normosmic IHH phenotype. PMID:23329188

  18. Growth, pubertal development, skeletal maturation and bone mass acquisition in athletes.

    Science.gov (United States)

    Georgopoulos, Neoklis A; Markou, Kostas B; Theodoropoulou, Anastasia; Vagenakis, George A; Mylonas, Panagiotis; Vagenakis, Apostolos G

    2004-01-01

    The genetic potentials for growth can be fully expressed only under favourable environmental conditions. Excessive physical training may negatively affect growth, especially during puberty. Sports that require a strict control of energy input in the presence of a high energy output are of particular concern. In gymnastics, a different pattern in skeletal maturation was observed, leading to an attenuation of growth potential ins Artistic Gymnasts (AG), more pronounced in males than in females, whereas in female Rhythmic Gymnasts (RG) the genetic predisposition to growth was preserved because of a late catch-up growth phenomenon. In all other sports not requiring strict dietary restrictions, no deterioration of growth has been documented. Intensive physical training and negative energy balance modify the hypothalamic pituitary set point at puberty, prolong the prepubertal stage and delay pubertal development and menarche in a variety of sports. In elite RG and AG the prepubertal stage is prolonged and pubertal development is entirely shifted to a later age, paralleling the bone age rather than the chronological age. Bone formation, and, consequently, BMD are enhanced by physical activity. In athletes, high-impact loading activities have been shown to improve BMD, while in sports requiring a lean somatotype, the delay in skeletal maturation and pubertal development, resulting from hypoestrogenemia, predisposes athletes to osteopenia. In AG, an increase in bone density is observed using the bone age as denominator.

  19. Pubertal status associations with reward and threat sensitivities and subcortical brain volumes during adolescence.

    Science.gov (United States)

    Urošević, Snežana; Collins, Paul; Muetzel, Ryan; Lim, Kelvin O; Luciana, Monica

    2014-08-01

    Adolescence is characterized by complex developmental processes that impact behavior, biology, and social functioning. Two such adolescence-specific processes are puberty and increases in reward sensitivity. Relations between these processes are poorly understood. The present study focused on examining unique effects of puberty, age, and sex on reward and threat sensitivities and volumes of subcortical brain structures relevant for reward/threat processing in a healthy sample of 9-18year-olds. Unlike age, pubertal status had a significant unique positive relationship with reward sensitivity. In addition, there was a trend for adolescent females to exhibit higher threat sensitivity with more advanced pubertal development and higher reward and threat sensitivity with older age. Similarly, there were significant puberty by sex interaction effects on striatal volumes, i.e., left nucleus accumbens and right pallidum. The present pattern of results suggests that pubertal development, independent of chronological age, is uniquely associated with reward hypersensitivity and with structural differences in striatal regions implicated in reward processing.

  20. Pubertal Pathways in Girls Enrolled in a Contemporary British Cohort

    Directory of Open Access Journals (Sweden)

    Krista Yorita Christensen

    2010-01-01

    Full Text Available Data from the Avon Longitudinal Study of Parents and Children were used to describe initiation of secondary sexual characteristic development of girls. Tanner stages of breast and pubic hair and menarche status were self-reported via mailed questionnaires, administered from ages 8–14. Initiation pathway was categorized as breast [thelarche] or pubic hair [pubarche] development alone, or synchronous. Average ages at beginning breast and pubic hair development were estimated using survival analysis. Factors associated with initiation pathway were assessed using logistic regression. Among the 3938 participants, the median ages at beginning breast and pubic hair development were 10.19 (95% CI: 10.14–10.24 and 10.95 (95% CI: 10.90–11.00 years. Synchronous initiation was the most commonly reported pathway (46.3%, followed by thelarche (42.1%. Girls in the pubarche pathway were less likely to be obese or overweight at age 8 or have an overweight or obese mother. Girls in the thelarche pathway were less likely to be of nonwhite race or be the third born or later child.

  1. Female sexuality

    Science.gov (United States)

    Rao, T.S. Sathyanarana; Nagaraj, Anil Kumar M.

    2015-01-01

    Sex is a motive force bringing a man and a woman into intimate contact. Sexuality is a central aspect of being human throughout life and encompasses sex, gender identities and roles, sexual orientation, eroticism, pleasure, intimacy, and reproduction. Sexuality is experienced and expressed in thoughts, fantasies, desires, beliefs, attitudes, values, behaviors, practices, roles and relationships. Though generally, women are sexually active during adolescence, they reach their peak orgasmic frequency in their 30 s, and have a constant level of sexual capacity up to the age of 55 with little evidence that aging affects it in later life. Desire, arousal, and orgasm are the three principle stages of the sexual response cycle. Each stage is associated with unique physiological changes. Females are commonly affected by various disorders in relation to this sexual response cycle. The prevalence is generally as high as 35–40%. There are a wide range of etiological factors like age, relationship with a partner, psychiatric and medical disorders, psychotropic and other medication. Counseling to overcome stigma and enhance awareness on sexuality is an essential step in management. There are several effective psychological and pharmacological therapeutic approaches to treat female sexual disorders. This article is a review of female sexuality. PMID:26330647

  2. Abused Sexuality- Experience of Sexuality Post Experiences of Sexual Abuse

    Directory of Open Access Journals (Sweden)

    Sunanda Jalote

    2016-02-01

    Full Text Available Sexual abuse has been happening from times immemorial and is that brutal aspect of society which also talk about spirituality, peace and harmony in the same breath. Youth gets irrevocably scarred by such childhood traumas which linger on in their adult life too. In the present study, an effort was made to study and understand how heterosexual and queer youth in contemporary middle class in Delhi explore the relationship sexual abuse survivors have with their own sexuality and how their negotiate their sexual selves. The secondary aim of the study was to investigate the function and effects of guilt, shame, desire, fantasies and gender roles in their lives and how, if at all, they connect to the experiences of sexual assault suffered by individuals within this socio-cultural group. The approach that frames this study is a discourse analytic approach and this is seen as central to the methodology of this study and the language used to talk about the findings and implications of this research.

  3. A Reevaluation of the Question: Is the Pubertal Resurgence in Pulsatile GnRH Release in the Male Rhesus Monkey (Macaca mulatta) Associated With a Gonad-Independent Augmentation of GH Secretion?

    Science.gov (United States)

    Shahab, M; Trujillo, M Vargas; Plant, T M

    2015-10-01

    A somatic signal has been posited to trigger the pubertal resurgence in pulsatile GnRH secretion that initiates puberty in highly evolved primates. That GH might provide such a signal emerged in 2000 as a result of a study reporting that circulating nocturnal GH concentrations in castrated juvenile male monkeys increased in a 3-week period immediately preceding the pubertal resurgence of LH secretion. The present study was conducted to reexamine this intriguing relationship, again in an agonadal model. Four castrated juvenile male monkeys were implanted with indwelling jugular catheters, housed in remote sampling cages, and subjected to 24 hours of sequential blood sampling (every 30 min) every 2 weeks from 19.5 to 22 months of age. Twenty-four-hour profiles of circulating GH concentrations were analyzed using the pulse detection algorithm, PULSAR, and developmental changes in pulsatile GH release with respect to the initiation of the pubertal rise of LH secretion (week 0; observed between 22.5 and 32 mo of age) were examined for significance by a repeated-measures ANOVA. Changes in the parameters of pulsatile GH secretion, including mean 24-hour GH concentration and GH pulse frequency and pulse amplitude for 3 (n = 4) and 6 (n = 3) months before week 0 were unremarkable and nonsignificant. These findings fail to confirm those of the earlier study and lead us to conclude that the timing of the pubertal resurgence of GnRH release in the male monkey is not dictated by GH. Reasons for the discrepancy between the two studies are unclear.

  4. Diagnostic Markers of Primary Infertility in Women of Reproductive Age with Hypothalamic Dysfunction in the Pubertal Period

    Directory of Open Access Journals (Sweden)

    Irina V. Zhukovets

    2017-09-01

    Full Text Available The aim of the study was to assess fertility in women of reproductive age with hypothalamic dysfunction (HD in the pubertal period and to determine the diagnostic significance of pro-inflammatory (TNF-α and IL-1β, anti-inflammatory cytokine (IL-10 and NF-kB activity in the diagnosis of primary infertility in these women. Materials and Methods: Fertility was assessed in 86 women of reproductive age with HD in the pubertal period. A comparative characteristic of fertile women (Group 1, n=46 and primary infertility women (Group 2, n=21 with HD in the pubertal period was performed. FPG and FPI were determined after 8 to 12 hours of fasting. Serum IRI concentrations were measured using an ELISA kit. The levels of TNF-α, IL-1β and IL-10 were determined in the venous blood serum after a 12-hour fasting, as well as in UA on the 21st day of the menstrual cycle using ELISA kits. The activity of NF-kB was determined in UA on the 21st day of the menstrual cycle using an enzyme immunoassay kit. Results: BMI in Group 1 was significantly lower than in Group 2: 22.63±2.68 kg/m2 versus 27.05±4.03kg/m2 (p=0.000. WC in women of Group 1 was 66.11±5.66cm versus 78.52±10.54cm in Group 2 (p = 0.000; WC >80cm was found in 2(4.4% and 14(66.7% women, respectively (p = 0.000. The average levels of FPG and FPI were significantly higher in Group 2. Serum levels of TNF-α and IL-1β in Group 2 were significantly higher than in Group 1. The serum level of anti-inflammatory cytokine IL-10 was significantly lower in Group 2; accordingly, the TNF-α/IL-10 ratio in Group 2 was 1.8 times higher than in Group 1. The IL-1β level in UA (P=0.000 and the TNF-α/IL-10 ratio (P=0.02 were significantly higher in women of Group 2 than Group 1, which indicated the pronounced inflammatory effects of TNF-α in the endometrium. Imbalance in the production of pro-inflammatory and anti-inflammatory factors indicated the activation of the Th-1 immune response with the formation of the

  5. Fashionably late partners have more fruitful encounters: Impact of the timing of co-infection and pathogenicity on sexual reproduction in Zymoseptoria tritici.

    Science.gov (United States)

    Suffert, Frédéric; Delestre, Ghislain; Carpentier, Florence; Gazeau, Gwilherm; Walker, Anne-Sophie; Gélisse, Sandrine; Duplaix, Clémentine

    2016-07-01

    The wheat pathogen Zymoseptoria tritici is a relevant fungal model organism for investigations of the epidemiological determinants of sexual reproduction. The objective of this experimental study was to determine which intrinsic factors, including parental fitness and timing conditions of infection, affect the numbers of ascospores produced. We first performed 28 crosses on adult wheat plants in semi-controlled conditions, with 10 isolates characterized for their fitness traits. We validated the efficiency of the crossing method, opening up new perspectives for epidemiological studies. We found that the ability to reproduce sexually was determined, at least partly, by the parental genotypes. We also found that the number of ascospores released was correlated with the mean size of the sporulating lesions of the parental isolates on the one hand, and the absolute difference in the latent periods of these isolates on the other. No functional trade-off between the two modes of reproduction in Z. tritici was revealed: there was no adaptive compromise between pathogenicity (asexual multiplication on leaves) and transmission (intensity of sexual reproduction on wheat debris). Moreover, a few days' difference in the latent periods of the two parental isolates, such that one progressed more rapidly in the host tissue than the other, seemed to be slightly beneficial to ascosporogenesis. This may be because the first parental isolate breaks down host defenses, thereby facilitating infection for the other parental isolate. However, a larger difference (a few weeks), generated by leaving two to three weeks between the inoculations of the plant with the parental isolates, was clearly detrimental to ascosporogenesis. In this case, the host tissues were likely colonized by the first isolate, leaving less host resources available for the second, consistent with a competition effect during the asexual stage.

  6. Sexual Regret

    OpenAIRE

    Leif Edward Ottesen Kennair; Mons Bendixen; David M. Buss

    2016-01-01

    The current study sought to answer three key questions about explaining the emotion of regret in the domain of casual sex: Are sex differences in sexual regret robust or attenuated in a highly egalitarian culture? What proximate psychological variables might explain sex differences in sexual regret? And what accounts for within-sex variation in experiences of sexual regret about casual sex. We conducted a study of 263 Norwegian students (ages 19–37) who reported how much they regretted having...

  7. Compulsory sexuality.

    Science.gov (United States)

    Emens, Elizabeth F

    2014-02-01

    Asexuality is an emerging identity category that challenges the common assumption that everyone is defined by some type of sexual attraction. Asexuals--those who report feeling no sexual attraction to others--constitute one percent of the population, according to one prominent study. In recent years, some individuals have begun to identify as asexual and to connect around their experiences interacting with a sexual society. Asexuality has also become a protected classification under the antidiscrimination law of one state and several localities, but legal scholarship has thus far neglected the subject. This Article introduces asexuality to the legal literature as a category of analysis, an object of empirical study, and a phenomenon of medical science. It then offers a close examination of the growing community of self-identified asexuals. Asexual identity has revealing intersections with the more familiar categories of gender, sexual orientation, and disability, and inspires new models for understanding sexuality. Thinking about asexuality also sheds light on our legal system. Ours is arguably a sexual law, predicated on the assumption that sex is important. This Article uses asexuality to develop a framework for identifying the ways that law privileges sexuality. Across various fields, these interactions include legal requirements of sexual activity, special carve-outs to shield sexuality from law, legal protections from others' sexuality, and legal protections for sexual identity. Applying this framework, the Article traces several ways that our sexual law burdens, and occasionally benefits, asexuals. This Article concludes by closely examining asexuality's prospects for broader inclusion into federal, state, and local antidiscrimination laws.

  8. Jongeren en sexualiteit 1974 [Young people and sexuality 1974

    NARCIS (Netherlands)

    Kooy, G.A.

    1977-01-01

    Contact with friends / relations with parents / leisure time / activities outdoors / drinking / parties / smoking / pattern of interest / relations with other sex / talking about personal problems and sexuality / age at which basic sexual information was acquired / sexual experiences / attitude to s

  9. Jongeren en sexualiteit 1974 [Young people and sexuality 1974

    NARCIS (Netherlands)

    Kooy, G.A.

    1974-01-01

    Contact with friends / relations with parents / leisure time / activities outdoors / drinking / parties / smoking / pattern of interest / relations with other sex / talking about personal problems and sexuality / age at which basic sexual information was acquired / sexual experiences / attitude to s

  10. Male sexuality.

    Science.gov (United States)

    Ginsberg, Terrie B

    2010-05-01

    It should be recognized that sexuality in the aging male is of such import that a complete sexual history must be performed. By taking a complete sexual history, facts can be obtained that will allow for appropriate focus relating to a holistic evaluation and will enable us to dispel antiquated sexual myths pertaining to the aging male. If initiated by the history taker, questions concerning sexuality may be discussed more comfortably by the patient. Erectile dysfunction, male sexual response cycle, testosterone, sexually transmitted diseases, human immunodeficiency virus, long-term illness, along with religion and culture are explored in this article with the aim of improving one's knowledge base, self reflection, and awareness of the importance of male sexuality. A complete understanding and appreciation of the aging male's medical history, surgical history, social history, and emotional history as well as his sexual, cultural, and religious concepts will allow the health care provider to better analyze information, and to recommend and provide appropriate advice and treatment to the aging male patient.

  11. [Sexual assaults].

    Science.gov (United States)

    Gosset, Didier; Hédouin, Valéry

    2002-04-01

    Examining a victim of sexual assault is a medico-legal emergency. It has to be performed within 72 h, in appropriate conditions. A recent laceration of the hymen does not necessarily indicate a rape, and conversely absence of trauma to a rape victim does not negate the validity of her claim to rape. A normal clinical examination does not exclude the possibility of a sexual abuse. Unlawful sexual intercourse is defined by a sexual penetration without valid consent. Specimen collection, to be considered as an evidence, must be sealed. Toxicological samples have to be performed to search a rape under influence.

  12. Internet Sexualities

    Science.gov (United States)

    Döring, Nicola

    The term “internet sexuality” (or OSA, online sexual activities) refers to sexual-related content and activities observable on the internet (cf. Adams, Oye, & Parker, 2003; Cooper, McLoughlin, & Campbell, 2000; Leiblum & Döring, 2002). It designates a variety of sexual phenomena (e.g., pornography, sex education, sexual contacts) related to a wide spectrum of online services and applications (e.g., websites, online chat rooms, peer-to-peer networks). If an even broader range of computer networks - such as the Usenet or bulletin board systems - is included in this extensional definition, one speaks of “online sexuality” or “cybersexuality.”

  13. Dairy intake in relation to breast and pubertal development in Chilean girls.

    Science.gov (United States)

    Gaskins, Audrey J; Pereira, Ana; Quintiliano, Daiana; Shepherd, John A; Uauy, Ricardo; Corvalán, Camila; Michels, Karin B

    2017-05-01

    Background: Frequent dairy consumption in childhood has been related to higher growth-hormone concentrations that may affect mammary gland and pubertal development.Objective: We evaluated the relation of dairy intake to breast composition at Tanner stage 4 and age at menarche.Design: A total of 515 Chilean girls are included in the Growth and Obesity Cohort Study. The subjects have been followed longitudinally since they were 3-4 y old (from 2006 to the present). Starting in 2013, diet was assessed every 6 mo via a 24-h recall. The breast fibroglandular volume (FGV) was measured with the use of dual-energy X-ray absorptiometry at Tanner stage 4. The date of menarche was reported every 6 mo. Our analysis included 290 girls with data on prospective diet and breast composition and 324 girls with data on prospective diet and age at menarche.Results: The mean ± SD breast FGV and percentage of fibroglandular volume (%FGV) (i.e., FGV divided by total breast volume times 100) at Tanner stage 4 was 81.7 ± 32.2 cm(3) and 42.0% ± 16.7%, respectively. Only sweetened, artificially flavored milk-based drinks were associated with the %FGV with girls who consumed >125 g/d having a %FGV that was 4.5% (95% CI: 0.9%, 8.1%) higher than that of girls who consumed none (P-trend = 0.007). Yogurt intake was associated with a lower FGV. Specifically, girls who consumed >125 g yogurt/d had -10.2 cm(3) (95% CI: -20.2, -0.3 cm(3)) less FGV than did girls who consumed no yogurt (P-trend = 0.03). The majority (90.7%) of girls in our cohort attained menarche before the data analyses with a mean ± SD age at menarche of 11.9 ± 0.7 y. In multivariable models, low-fat dairy, low-fat milk, and yogurt intakes were associated with a later age at menarche. In particular, girls who consumed >125 g yogurt/d had menarche, on average, 4.6 mo (95% CI: 1.9, 7.4 mo) later than girls who consumed no yogurt (P-trend = 0.01).Conclusion: More-frequent consumption of sweetened, artificially-flavored milk

  14. Perceived realism moderates the relation between sexualized media consumption and permissive sexual attitudes in Dutch adolescents.

    Science.gov (United States)

    Baams, Laura; Overbeek, Geertjan; Dubas, Judith Semon; Doornwaard, Suzan M; Rommes, Els; van Aken, Marcel A G

    2015-04-01

    This study examined whether the development of sexualized media consumption and permissive sexual attitudes would be more strongly interrelated when adolescents perceived sexualized media images as highly realistic. We used data from a three-wave longitudinal sample of 444 Dutch adolescents aged 13-16 years at baseline. Results from parallel process latent growth modeling multigroup analyses showed that higher initial levels of sexualized media consumption were associated with higher initial level of permissive sexual attitudes. Moreover, increases of sexualized media consumption over time were associated with increases of permissive sexual attitudes over time. Considering the moderation by perceived realism, we found these effects only for those who perceived sexualized media as more realistic. Findings for male and female adolescents were similar except for the relations between initial levels and subsequent development. Among male adolescents who perceived sexualized media images to be realistic, higher initial levels of permissive sexual attitudes were related to subsequent less rapid development of sexualized media consumption. For male adolescents who perceived sexualized media to be less realistic, higher initial levels of sexualized media consumption were related to a subsequent less rapid development of permissive sexual attitudes. These relations were not found for female adolescents. Overall, our results suggest that, in male and female adolescents, those with a high level of perceived realism showed a correlated development of sexualized media consumption and permissive sexual attitudes. These findings point to a need for extended information on how to guide adolescents in interpreting and handling sexualized media in everyday life.

  15. [Questionnaires in sexual medicine].

    Science.gov (United States)

    Giuliano, F

    2013-07-01

    Screening, diagnosis and assessment of the management of male and female sexual dysfunctions have been greatly improved by the scientific development of self-administered questionnaires. Their use became the rule in clinical trials and epidemiological surveys. Nevertheless, their routine use has not yet become part of daily urological practice. Even if these tools replace neither the patient interview and medical history and the psychological and social context of the sexual behavior, nor clinical examination, they are of great assistance for determining management and are also highly reliable. Medical literature was reviewed and combined with expert opinion of the author. We present here several questionnaires which have been validated in their French version with the methodology for the calculation of the scores. The International Index of Erectile Function (15 items) and two abbreviated versions, the Erectile Function domain (six items) and the Sexual Health Inventory for Men (five questions) are mainly of use for patients with erectile dysfunction. They provide a robust classification of the severity of the condition. The Premature Ejaculation Profile (four questions) is used for patients with premature ejaculation. It describes premature ejaculation with the following criteria: time to ejaculation, control over ejaculation, the level of distress. The Male Health Sexual Questionnaire (25 questions) provides with a wider and more comprehensive approach to male sexuality of male sexuality including: erection, ejaculation, desire and satisfaction. This questionnaire is particularly useful to investigate ejaculatory disorders. Lastly, the Female Sexual Function Index (19 questions) is the tool of choice for female sexuality with questions regarding desire, arousal, lubrication, orgasm, satisfaction and pain. Validated, user-friendly questionnaires are available in French language for the diagnosis and the follow-up of sexual dysfunctions in both men and women

  16. Sexual revolutions

    NARCIS (Netherlands)

    Hekma, G.; Giami, A.

    2014-01-01

    The sexual revolution of 1960-1980 created a major break in attitudes and practices in Western societies. It created many new freedoms for gay men, youth and women, in terms of sexual imagery, information, and rights. Leftists denounced the revolution's consumerism whilst feminists lamented its cont

  17. Sexual Health

    Science.gov (United States)

    ... health By Mayo Clinic Staff Sexual health basics Sexuality is part of being human. Love, affection and intimacy all play a role in healthy relationships from childhood through old age. You often hear about the importance of physical health, mental health and spiritual health, ...

  18. Sexual prejudice.

    Science.gov (United States)

    Herek, Gregory M; McLemore, Kevin A

    2013-01-01

    Despite shifts toward greater acceptance in U.S. public opinion and policy, lesbian, gay, and bisexual people remain widely stigmatized. This article reviews empirical research on sexual prejudice, that is, heterosexuals' internalization of cultural stigma, manifested in the form of negative attitudes toward sexual minorities and same-sex desires and behaviors. After briefly reviewing measurement issues, we discuss linkages between sexual prejudice and religion, gender, sexuality, and related variables, and consider how the cultural institutions encompassing these domains create a social context within which individual expressions of prejudice can meet important psychological needs. These include needs for securing social acceptance, affirming values that are central to one's self-concept, and avoiding anxiety and other negative emotions associated with threats to self-esteem. We conclude by discussing factors that may motivate heterosexuals to reduce their own sexual prejudice, including intergroup contact, as well as avenues for future empirical inquiry.

  19. Sexual imprinting can induce sexual preferences for exaggerated parental traits.

    Science.gov (United States)

    ten Cate, Carel; Verzijden, Machteld N; Etman, Eric

    2006-06-06

    Sexual preferences in animals are often skewed toward mates with exaggerated traits. In many vertebrates, parents provide, through the learning process of "sexual imprinting," the model for the later sexual preference. How imprinting can result in sexual preferences for mates having exaggerated traits rather than resembling the parental appearance is not clear. We test the hypothesis that a by-product of the learning process, "peak shift", may induce skewed sexual preferences for exaggerated parental phenotypes. To this end, zebra finch (Taeniopygia guttata) males were raised by white parents, with beak color as the most prominent sexual dimorphism. We manipulated this feature with nail varnish. At adult age, each male was given a preference test in which he could choose among eight females with beak colors ranging from more extreme on the paternal to more extreme on the maternal side. The males preferred females with a beak of a more extreme color than that of their mothers, i.e., they showed a peak shift. Sexual imprinting can thus generate skewed sexual preferences for exaggerated maternal phenotypes, phenotypes that have not been present at the time of the learning. We suggest that such preferences can drive the evolution of sexual dimorphism and exaggerated sexual traits.

  20. Ferro, cobre e zinco em adolescentes no estirão pubertário Iron, copper and zinc in adolescents during pubertal growth spurt

    Directory of Open Access Journals (Sweden)

    Marcia R.D. Urbano

    2002-01-01

    Full Text Available Objetivo: verificar o estado nutricional relativo ao ferro, cobre e zinco e a correlação entre índice de massa corporal, níveis séricos e dietéticos desses elementos, em adolescentes durante o estirão pubertário. Métodos: estudo descritivo, do tipo corte transversal, envolvendo uma amostra de 47 adolescentes atendidos em ambulatório de adolescência clínica, durante o período de março a dezembro de 1999, que se apresentavam no estirão pubertário, do total de 360 que freqüentaram o ambulatório no período, sendo 19 rapazes na faixa etária de 12,3 a 16 anos, e 28 moças na faixa etária de 11,1 a 13,6 anos. Variáveis analisadas: dietética (recordatório de 24 horas, freqüência e registro alimentar para determinar a ingestão de ferro, cobre e zinco; antropométrica (peso e altura para aferição do índice de massa corporal; bioquímica (dosagem sérica de ferro pelo kit in vitro Diagnóstica, ferritina pelo kit Immulite, cobre e zinco por espectrofotometria de absorção atômica. Utilizou-se o coeficiente de Spearman para análise estatistíca. Resultados: dos 47 adolescentes em estirão pubertário, apresentaram ingestão adequada de: ferro (95% e 36%, cobre (53% e 57% e zinco (21% e 21% nos sexos masculino e feminino, respectivamente. A maioria dos adolescentes era eutrófica segundo os percentis do IMC. Bioquimicamente, os rapazes apresentaram valores normais para ferro e zinco em toda a amostra; para cobre em 95% e para ferritina em 84%. As moças também apresentaram valores normais de ferro e zinco; para cobre em 96,4% e para ferritina em 96%. Não houve correlação estatisticamente significante entre IMC e concentração sérica de ferro, ferritina, cobre e zinco, e entre concentração sérica e ingestão dietética dos minerais estudados, nem tampouco para a relação ferro sérico e ferritina. Conclusões: não se sabe, até o momento, se os níveis séricos de zinco e cobre flutuam durante o crescimento, ou se

  1. Comparative proteomic profiling and possible toxicological mechanism of acute injury induced by carbon ion radiation in pubertal mice testes

    Science.gov (United States)

    Zhang, Hong

    2016-07-01

    We investigated potential mechanisms of acute injury in pubertal mice testes after exposure to carbon ion radiation (CIR). Serum testosterone was measured following whole-body irradiation with a 2Gy carbon ion beam. Comparative proteomic profiling and Western blotting were applied to identify potential biomarkers and measure protein expression, and terminal dUTP nick end-labeling (TUNEL) was performed to detect apoptotic cells. Immunohistochemistry and immunofluorescence were used to investigate protein localization. Serum testosterone was lowest at 24h after CIR, and 10 differentially expressed proteins were identified at this time point that included eIF4E, an important regulator of initiation that combines with mTOR and 4EBP1 to control protein synthesis via the mTOR signalling pathway during proliferation and apoptosis. Protein expression and localization studies confirmed their association with acute injury following exposure to CIR. These three proteins may be useful molecular markers for detecting abnormal spermatogenesis following exposure to environmental and cosmic radiation

  2. Effects of sex and sexual orientation on self-reported attraction and viewing times to images of men and women: testing for category specificity.

    Science.gov (United States)

    Lippa, Richard A

    2012-02-01

    In a paradigm that asked participants to rate the sexual attractiveness of male and female swimsuit models, Lippa, Patterson, and Marelich (2010) showed that heterosexual men's category specificity exceeded heterosexual women's in two ways: (1) Heterosexual men showed much larger differences in their attraction and viewing times to male versus female photo models than heterosexual women, and (2) heterosexual men's attractions to female but not male models increased with model attractiveness whereas heterosexual women's attractions to both sexes increased with model attractiveness. The current study used the same paradigm to study category specificity in homosexual and heterosexual participants. In addition to replicating previous findings for heterosexual men and women, the results showed that homosexual men were high on category specificity, like heterosexual men, whereas lesbians showed lower levels of category specificity than men, but sometimes higher levels than heterosexual women.

  3. Efeito da duração do tratamento com progestágeno e da maturidade sexual na taxa de prenhez em novilhas de corte: avaliação econômica e biológica Effect of the duration of progestagen exposure and sexual maturity on the pregnancy rate of beef heifers: economic and biological evaluation

    Directory of Open Access Journals (Sweden)

    Luiz Francisco Machado Pfeifer

    2009-07-01

    Full Text Available Os objetivos neste experimento foram avaliar o efeito do tempo de exposição a um progestágeno (P4 na taxa de prenhez de novilhas púberes e pré-púberes inseminadas em tempo-fixo (IATF e estudar o retorno econômico dos protocolos utilizados, por meio da comparação desses protocolos ao sistema tradicional de acasalamento natural aos 26 meses de idade. Foram utilizadas 114 novilhas da raça Bradford com 16 meses de idade, classificadas em quatro grupos de acordo com o tratamento e a maturidade sexual: GPPLP - pré-puberes, longo tratamento com P4 (n=21; e GPPCP - pré-puberes, curto tratamento com (n=19; GPLP - púberes, longo tratamento com P4 (n=34; e GPCP - púberes, curto tratamento com P4 (n=40. As novilhas do GPPLP e GPLP receberam no dia -8 um pessário intravaginal impregnado com acetato de medroxiprogesterona. No dia 0, o pessário foi removido e outro foi inserido, juntamente com uma injeção de 2,5 mg de benzoato de estradiol (BE. No dia 8, o pessário foi retirado e as novilhas receberam 0,5 mg de BE e 250 µg de cloprostenol sódico. A inseminação artificial em tempo fixo (IATF foi realizada 54 horas depois. As novilhas do GPPCP e GPCP receberam o mesmo tratamento de sincronização dos grupos GPPLP e GPLP, com exceção do AMP do dia -8 ao dia 0. A taxa de prenhez foi maior nas novilhas púberes (60,3% que nas pré-puberes (35,0%. No entanto, não foi detectado efeito do tempo de tratamento na taxa de prenhez nas novilhas púberes e pré-puberes. A resposta econômica na utilização de protocolos com P4 foi maior em novilhas aos 16 meses que no sistema de acasalamento aos 26 meses. A exposição prolongada a um P4 não foi eficiente para aumentar a taxa de prenhez de novilhas submetidas a IATF.The aim of this experiment was to evaluate the effect of the duration of progestagen (P4 exposure and sexual maturity of prepubertal and pubertal heifers submitted to timed artificial insemination (TAI. A hundred and fourteen 16

  4. Reward sensitivity for a palatable food reward peaks during pubertal developmental in rats

    Directory of Open Access Journals (Sweden)

    Chris M Friemel

    2010-07-01

    Full Text Available Puberty is a critical period for the initiation of drug use and abuse. Because early drug use onset often accounts for a more severe progression of addiction, it is of importance to understand the underlying mechanisms and neurodevelopmental changes during puberty that are contributing to enhanced reward processing in teenagers. The present study investigated the progression of reward sensitivity towards a natural food reward over the whole course of adolescence in male rats (postnatal days 30–90 by monitoring consummatory, motivational behavior and neurobiological correlates of reward. Using a limited-free intake paradigm, consumption of sweetened condensed milk (SCM was measured repeatedly in adolescent and adult rats. Additionally, early- and mid-pubertal animals were tested in Progressive Ratio responding for SCM and c-fos protein expression in reward-associated brain structures was examined after odor-conditioning for SCM. We found a transient increase in SCM consumption and motivational incentive for SCM during puberty. This increased reward sensitivity was most pronounced around mid-puberty. The behavioral findings are paralleled by enhanced c-fos staining in reward-related structures revealing an intensified neuronal response after reward-cue presentation, distinctive for pubertal animals. Taken together, these data indicate an increase in reward sensitivity during adolescence accompanied by enhanced responsiveness of reward associated brain structures to incentive stimuli, and it seems that both is strongly pronounced around mid-puberty. Therefore, higher reward sensitivity during pubertal maturation might contribute to the enhanced vulnerability of teenagers for the initiation of experimental drug use.

  5. Risking it for Love: Romantic Relationships and Early Pubertal Development Confer Risk for later Disruptive Behavior Disorders in African-American Girls Receiving Psychiatric Care

    Science.gov (United States)

    Rodriguez, Erin M.; Nichols, Sara; Emerson, Erin; Donenberg, Geri R.

    2014-01-01

    Disruptive behavior problems (DBP) represent a growing concern for young women (e.g., Snyder & Sickmund, 2006), but gender-specific investigations have been traditionally underrepresented in this area. The purpose of this study is to examine the associations among gender-relevant risk factors for DBP among 217 African American girls in psychiatric care. African American girls, 12–16 years old (M=14.6; SD=1.2), and their primary female caregivers (N=254) were recruited from outpatient mental health clinics and reported on girls’ DBP, heterosexual dating experiences (romantic and sexual), peer relationships, pubertal development, and self-silencing at baseline, 6-, and 12-months. Structural Equation Modeling examined evidence for full versus mediated (via self-silencing) models and the structural relationships (direct and indirect) among key study variables. Results suggest that the full model was a significantly better fit than the mediated model as indicated by a Chi-squared difference test (p girls. Indirect effects analyses suggested that girls’ suppression of relational needs, assessed through a measure of self-silencing, explained the association between peer relationships and DBP. Findings highlight the importance of the relational context for girls’ DBP, with treatment implications supporting relationship-based models of care, early intervention, and skill building around negotiating needs with peers and partners. PMID:24748499

  6. PSA-NCAM in the posterodorsal medial amygdala is necessary for the pubertal emergence of attraction to female odors in male hamsters.

    Science.gov (United States)

    Job, Martin O; Cooke, Bradley M

    2015-09-01

    During puberty, attention turns away from same-sex socialization to focus on the opposite sex. How the brain mediates this change in perception and motivation is unknown. Polysialylated neural cell adhesion molecule (PSA-NCAM) virtually disappears from most of the central nervous system after embryogenesis, but it remains elevated in discrete regions of the adult brain. One such brain area is the posterodorsal subnucleus of the medial amygdala (MePD). The MePD has been implicated in male sexual attraction, measured here as the preference to investigate female odors. We hypothesize that PSA-NCAM gates hormone-dependent plasticity necessary for the emergence of males' attraction to females. To evaluate this idea, we first measured PSA-NCAM levels across puberty in several brain regions, and identified when female odor preference normally emerges in male Syrian hamsters. We found that MePD PSA-NCAM staining peaks shortly before the surge of pubertal androgen and the emergence of preference. To test the necessity of PSA-NCAM for female odor preference, we infused endo-neuraminidase-N into the MePD to deplete it of PSAs before female odor preference normally appears. This blocked female odor preference, which suggests that PSA-NCAM facilitates behaviorally relevant, hormone-driven plasticity.

  7. Teenagers' Sexual Behavior in Sweden, Europe

    Institute of Scientific and Technical Information of China (English)

    Lars I Holmberg; Dan Hellberg

    2005-01-01

    Objective To investigate the development of sexuality from early to late adolescence,and to compare girls and boys of different agesMethods A cross sectional survey in all schools was performed covering all pupilsbetween 13 and 18years of age that were in school when the survey was conducted. Avalidated instrument, Q90, created for use in teenagers was distributed in the class-rooms to 3 216 teenagers. Q90 covers 30 questions about body development andsexual behavior. Non-response was insignificant (n=19; 0. 6%).Results Pubertal development was considered "early" or "late" by about 50% ofboth boys and girls. Eighty percent of the 13 to 15 years old boys and girls had had aromance and 30% had experience of sexual cuddling (petting), while significantlymore girls than boys had sexual intercourse (18% vs 13%; odds ratio 1.5, 95% CI1.1-1.9). The difference between girls and boys remained in those being 16-18 yearsold, where 63% of the girls and 53% of the boys (odds ratio 1.5, 95% CI 1.2-1.9)admitted having intercourse. Mean age at first intercourse was 14.9 and 15 years,respectively. At 16-18years of age, 23% of the sexually active girls, as compared with25% of the boys estimated that they had had 6 or more sexual partners. About 30% ofthe adolescents, irrespective of age and gender, did not use contraceptives at theirfirst and latest intercourse. Eight percent of the older girls had been pregnant, andthey had an increased history of sexually transmitted infections, as compared withthe boys (6.2% vs 2.7%; odds ratio 2.4, 95% CI 1.2-5.0).Conclusion Exploring sexuality and experimentation is a normal behavior inadolescence. The results of this study, however, indicate that there are substantialgroups of teenagers who practice sexual risk-taking. In addition to general sexualeducation, programs should also be directed to define sexual risks and its consequences.

  8. Genital Involvement In Pre-Pubertal Pediatric Population: A Rare Aspect of Crohn’s Disease

    Directory of Open Access Journals (Sweden)

    Qurratul Ann Warsi

    2016-09-01

    Full Text Available Crohn’s disease is an inflammatory bowel disease (IBD, characterized by chronic intestinal inflammation that causes the loss of immune tolerance leading to bizarre inflammatory signals and disruption of mucosal barriers. Environmental triggers and interaction of genetic determinants also play an indispensible role. In this case report, we present a pre-pubertal girl with intermittent and refractory genital swelling. We emphasize that Crohn’s disease must be considered in the differential diagnosis of recurrent, non-tender, erythematous and edematous lesions of the genital area. We conclude with future directions for diagnosing and managing vulvar Crohn’s disease in pediatric population.

  9. Excess of leptin inhibits hypothalamic KiSS-1 expression in pubertal mice

    Directory of Open Access Journals (Sweden)

    Sung Yeon Ahn

    2012-09-01

    Full Text Available &lt;B&gt;Purpose:&lt;/B&gt; Leptin has been considered a link between metabolic state and reproductive activity. Defective reproductive function can occur in leptin-deficient and leptin-excessive conditions. The aim of this study was to examine the effects of centrally injected leptin on the hypothalamic &lt;I&gt;KiSS-1&lt;/I&gt; system in relation to gonadotropin-releasing hormone (GnRH action in the initial stage of puberty. &lt;B&gt;Methods:&lt;/B&gt; Leptin (1 μg was injected directly into the ventricle of pubertal female mice. The resultant gene expressions of hypothalamic &lt;I&gt;GnRH&lt;/I&gt; and &lt;I&gt;KiSS-1&lt;/I&gt; and pituitary LH, 2 and 4 hours after injection, were compared with those of saline-injected control mice. The changes in the gene expressions after blocking the GnRH action were also analyzed. &lt;B&gt;Results:&lt;/B&gt; The basal expression levels of &lt;I&gt;KiSS-1&lt;/I&gt;, GnRH, and LH were significantly higher in the pubertal mice than in the prepubertal mice. The 1-μg leptin dose significantly decreased the mRNA expression levels of &lt;I&gt;KiSS-1&lt;/I&gt;, GnRH, and LH in the pubertal mice. A &lt;I&gt;GnRH&lt;/I&gt; antagonist significantly increased the &lt;I&gt;KiSS-1&lt;/I&gt; and GnRH mRNA expression levels, and the additional leptin injection decreased the gene expression levels compared with those in the control group. &lt;B&gt;Conclusion:&lt;/B&gt; The excess leptin might have suppressed the central reproductive axis in the pubertal mice by inhibiting the &lt;I&gt;KiSS-1&lt;/I&gt; expression, and this mechanism is independent of the GnRH-LHestradiol feedback loop.

  10. Fatness rather than leptin sensitivity determines the timing of puberty in female mice.

    Science.gov (United States)

    Bohlen, Tabata M; Silveira, Marina A; Zampieri, Thais T; Frazão, Renata; Donato, Jose

    2016-03-05

    Leptin is a permissive factor for the onset of puberty. However, changes in adiposity frequently influence leptin sensitivity. Thus, the objective of the present study was to investigate how changes in body weight, fatness, leptin levels and leptin sensitivity interact to control the timing of puberty in female mice. Pre-pubertal obesity, induced by raising C57BL/6 mice in small litters, led to an early puberty onset. Inactivation of Socs3 gene in the brain or exclusively in leptin receptor-expressing cells reduced the body weight and leptin levels at pubertal onset, and increased leptin sensitivity. Notably, these female mice exhibited significant delays in vaginal opening, first estrus and onset of estrus cyclicity. In conclusion, our findings suggest that increased leptin sensitivity did not play an important role in favoring pubertal onset in female mice. Rather, changes in pubertal body weight, fatness and/or leptin levels were more important in influencing the timing of puberty.

  11. Swimming physiology of European silver eels (Anguilla anguilla L.): energetic costs and effects on sexual maturation and reproduction

    Science.gov (United States)

    van den Thillart, Guido E. E. J. M.

    2010-01-01

    The European eel migrates 5,000–6,000 km to the Sargasso Sea to reproduce. Because they venture into the ocean in a pre-pubertal state and reproduce after swimming for months, a strong interaction between swimming and sexual maturation is expected. Many swimming trials have been performed in 22 swim tunnels to elucidate their performance and the impact on maturation. European eels are able to swim long distances at a cost of 10–12 mg fat/km which is 4–6 times more efficient than salmonids. The total energy costs of reproduction correspond to 67% of the fat stores. During long distance swimming, the body composition stays the same showing that energy consumption calculations cannot be based on fat alone but need to be compensated for protein oxidation. The optimal swimming speed is 0.61–0.67 m s−1, which is ~60% higher than the generally assumed cruise speed of 0.4 m s−1 and implies that female eels may reach the Sargasso Sea within 3.5 months instead of the assumed 6 months. Swimming trials showed lipid deposition and oocyte growth, which are the first steps of sexual maturation. To investigate effects of oceanic migration on maturation, we simulated group-wise migration in a large swim-gutter with seawater. These trials showed suppressed gonadotropin expression and vitellogenesis in females, while in contrast continued sexual maturation was observed in silver males. The induction of lipid deposition in the oocytes and the inhibition of vitellogenesis by swimming in females suggest a natural sequence of events quite different from artificial maturation protocols. PMID:20390348

  12. [Benefit of network education to college students' knowledge about sexual and reproductive health in Ningbo city].

    Science.gov (United States)

    Wang, Guo-yao; Ji, Yun-xin; Ding, Hui-qing; Gui, Zhong-bao; Liang, Xiao-ming; Fu, Jian-fei; Cheng, Yue

    2015-12-01

    To investigate how network education can improve college students' knowledge on sexual and reproductive health in Ningbo city. From December 2012 to June 2013, we conducted a questionnaire investigation among college students in Ningbo city about the effects of network education on their knowledge about sexual psychology, sexual physiology, sexual ethics, and reproductive health. A total of 7 362 college students accomplished the investigation, of whom 2 483 (42.1% males and 57.9% females) received network education, while the other 4 879 (24.1% males and 75.9% females) did not. Approximately 47.1% of the male and 28.0% of the female students acquired sexual and reproductive knowledge via network education. Reproductive health-related network education significantly enriched the students' knowledge about the reproductive system and sex, pubertal development, sexual physiology, conception and embryonic development, methods of contraception, sexual psychology, sexually transmitted diseases and their prevention, pregnancy care and eugenics, and environment- and occupation-related reproductive health (P reproductive health knowledge (P reproductive health-related network education showed a significantly higher rate of masturbation (P education can enhance the effect of reproductive health education among college students and improve their sexual experience and health.

  13. Sexuality and Sexual Dysfunctions in Bipolar Disorder

    OpenAIRE

    Zeynep Namli; Gonca Karakus; Lut Tamam; Mehmet Emin Demirkol

    2016-01-01

    In the clinical course of bipolar disorder, there is a reduction in sexual will during depressive episodes and inappopriate sexual experiences and hypersexuality occurs during manic episodes. Up to now, studies focused on sexual side effects of drugs. Sexual violence, sexually transmitted diseases, contraception methods, unplanned pregnancies need to be assessed carefully in bipolar disorder patients. This review focused on sexuality and sexual dysfunctions in the course of bipolar disorder. ...

  14. Adult Sexual Outcomes of Child Sexual Abuse Vary According to Relationship Status.

    Science.gov (United States)

    Vaillancourt-Morel, Marie-Pier; Godbout, Natacha; Sabourin, Stéphane; Briere, John; Lussier, Yvan; Runtz, Marsha

    2016-04-01

    This study tested a moderation model in which the association between child sexual abuse severity and negative sexual outcomes (i.e., sexual avoidance and compulsivity) differed as a function of relationships status (i.e., single, cohabiting, and married individuals). A sample of 1,033 adults completed self-report questionnaires online, and 21.5% reported childhood sexual abuse. Path analyses indicated that child sexual abuse severity was associated with higher sexual compulsivity in single individuals, both higher sexual avoidance and compulsivity in cohabiting individuals, and higher sexual avoidance in married individuals. The moderation model was invariant across men and women. These results suggest that the time course of negative sexual outcomes associated with child sexual abuse may follow distinct patterns of expression according to relationship status. © 2016 American Association for Marriage and Family Therapy.

  15. SEXUAL BEHAVIOR OF STREET CHILDREN.

    Science.gov (United States)

    Stojadinović, Aleksandra; Batrnek Antonić, Daliborka; Perinović, Marija; Rončević, Nevenka

    2015-01-01

    Street children and youth are at risk of getting engaged in different behaviors including risky sexual behavior, which adversely affects their development and health. The aim of this study was to examine sexual behavior of street children and youth, and the risks and consequences associated with sexual behavior. A pilot study was conducted on a sample of 50 users of the Drop-in Centre for Street Children in Novi Sad, from 10 to 19 years of age. The study was conducted by a psychologist through structured interviews, with prior consent of the adolescent and parent. Among the respondents who were sexually active, 41.2% had had the first sexual intercourse by the age of 12, their median age at that time being 14 years, while the age at the time of the first sexual intercourse is 16 years in the general population of Serbia. The majority of sexually active adolescents had several partners, one male adolescent had sex with a person of the same sex, and one was paid for sex. Very few respondents used a condom. Among 15 male sexually active respondents, three (ages 11, 12 and 14) were forced to have unwanted sexual intercourse, and a quarter of adolescents (three boys and one girl) were forced to do something unwanted during sex. Despite a small and unrepresentative sample, the results of this study indicate serious problems and significant risks associated with sexual behavior of children and young people who live and work in streets. This pilot study suggests that it is necessary to conduct new research on sexual behavior of street children and youth on a representative sample and with appropriate methodology. The results of a new study should be used to plan and carry out appropriate preventive measures regarding sexual behavior of street children.

  16. High-Throughput Sequencing Reveals Hypothalamic MicroRNAs as Novel Partners Involved in Timing the Rapid Development of Chicken (Gallus gallus) Gonads.

    Science.gov (United States)

    Han, Wei; Zou, Jianmin; Wang, Kehua; Su, Yijun; Zhu, Yunfen; Song, Chi; Li, Guohui; Qu, Liang; Zhang, Huiyong; Liu, Honglin

    2015-01-01

    Onset of the rapid gonad growth is a milestone in sexual development that comprises many genes and regulatory factors. The observations in model organisms and mammals including humans have shown a potential link between miRNAs and development timing. To determine whether miRNAs play roles in this process in the chicken (Gallus gallus), the Solexa deep sequencing was performed to analyze the profiles of miRNA expression in the hypothalamus of hens from two different pubertal stages, before onset of the rapid gonad development (BO) and after onset of the rapid gonad development (AO). 374 conserved and 46 novel miRNAs were identified as hypothalamus-expressed miRNAs in the chicken. 144 conserved miRNAs were showed to be differentially expressed (reads > 10, P 4.0, P rapid development of chicken gonads. Considering the characteristics of miRNA functional conservation, the results will contribute to the research on puberty onset in humans.

  17. Parents, peers, and sexual values influence sexual behavior during the transition to college.

    Science.gov (United States)

    Wetherill, Reagan R; Neal, Dan J; Fromme, Kim

    2010-06-01

    Several decades of research have identified the contributions of psychosocial influences on adolescent and young adult sexual behavior; however, few studies have examined parental and peer influence and sexual values during the transition from high school to college. The current study tested the influence of sexual values and perceived awareness and caring (PAC), or beliefs about how much parents and peers know and care about students' behavior, on sexual behavior during this transitional period. Using data from a longitudinal study, generalized estimating equations and the generalized linear model were used to examine the associations among sexual values, parental and peer PAC, and sexual behavior, both cross-sectionally and longitudinally. Participants (N = 1,847; 61% female) completed web-based surveys the summer before college matriculation and at the end of the first semester in college. Results indicated that individuals with high levels of both parental and peer PAC engaged in less frequent sexual behaviors and that PAC moderated the effect of sexual values on sexual behaviors. Furthermore, both PAC variables decreased during the transition from high school to college, and high school sexual values, parental PAC, and their interaction predicted the number of sexual partners during the first semester of college. Only sexual values and high school unsafe sexual behaviors predicted unsafe sexual behavior in college. Findings suggest that complex associations exist among perceived awareness and caring, sexual values, and sexual behaviors, and that the transition from high school to college may be an ideal time for safer-sex interventions.

  18. Risking it for love: romantic relationships and early pubertal development confer risk for later disruptive behavior disorders in African-American girls receiving psychiatric care.

    Science.gov (United States)

    Javdani, Shabnam; Rodriguez, Erin M; Nichols, Sara R; Emerson, Erin; Donenberg, Geri R

    2014-11-01

    Disruptive behavior problems (DBP) represent a growing concern for young women (e.g., Snyder and Sickmund, 2006), but gender-specific investigations have been traditionally underrepresented in this area. The purpose of this study is to examine the associations among gender-relevant risk factors for DBP among 217 African American girls in psychiatric care. African American girls, 12-16 years old (M = 14.6; SD = 1.2), and their primary female caregivers (N = 254) were recruited from outpatient mental health clinics and reported on girls' DBP, heterosexual dating experiences (romantic and sexual), peer relationships, pubertal development, and self-silencing at baseline, 6-, and 12 months. Structural Equation Modeling examined evidence for full versus mediated (via self-silencing) models and the structural relationships (direct and indirect) among key study variables. Results suggest that the full model was a significantly better fit than the mediated model as indicated by a Chi-squared difference test (p romantic dating experiences and lower quality peer relationships at baseline predicted DBP at 12 months. Sexual dating experiences were more strongly linked with DBP at 12 months for early maturing compared to average or later maturing girls. Indirect effects analyses suggested that girls' suppression of relational needs, assessed through a measure of self-silencing, explained the association between peer relationships and DBP. Findings highlight the importance of the relational context for girls' DBP, with treatment implications supporting relationship-based models of care, early intervention, and skill building around negotiating needs with peers and partners.

  19. A study of time- and sex-dependent effects of vortioxetine on rat sexual behavior: Possible roles of direct receptor modulation.

    Science.gov (United States)

    Li, Yan; Pehrson, Alan L; Oosting, Ronald S; Gulinello, Maria; Olivier, Berend; Sanchez, Connie

    2017-07-15

    Treatment-related sexual dysfunction is a common side effect of antidepressants and contributes to patient non-compliance or treatment cessation. However, the multimodal antidepressant, vortioxetine, demonstrates low sexual side effects in depressed patients. To investigate the mechanisms involved, sexual behavior was assessed in male and female rats after acute, and repeated (7 and 14 days) treatment with vortioxetine, flesinoxan (a 5-HT1A receptor agonist), CP-94253 (a 5-HT1B receptor agonist), or ondansetron (a 5-HT3 receptor antagonist). These selective ligands were chosen to simulate vortioxetine's direct modulation of these receptors. Paroxetine was also included in the male study. Acute and repeated treatment with vortioxetine at doses corresponding to clinical levels (based on serotonin transporter occupancy) had minimal effects on sexual behavior in male and female rats. High dose vortioxetine plus flesinoxan (to mimic predicted clinical levels of 5-HT1A receptor occupancy by vortioxetine) facilitated male rat sexual behavior (acutely) while inhibiting female rat proceptive behavior (both acutely and after 14 days treatment). The selective serotonin reuptake inhibitor, paroxetine, inhibited male sexual behavior after repeated administration (7 and 14 days). Flesinoxan alone facilitated male sexual behavior acutely while inhibiting female rat proceptive behavior after repeated administration (7 and 14 days). CP-94253 inhibited sexual behavior in both male and female rats after repeated administration. Ondansetron had no effect on sexual behavior. These findings underline the complex serotonergic regulation of sexual behavior and indicate that the low sexual side effects of vortioxetine found in clinical studies are likely associated with its direct modulation of serotonin receptors. Copyright © 2017. Published by Elsevier Ltd.

  20. Sexual Problems

    Science.gov (United States)

    ... concern causing distress can be classified as a dysfunction and can be lifelong or begin at any age. It can be situational or constant. Sexual disorders can affect men and women and are classified into four categories: desire disorders, ...

  1. Sexual Health

    Science.gov (United States)

    ... occurs in both men and women, and is normal. Knowing how your sexual response and feelings change, and how to enjoy your sex life despite these changes, is part of healthy aging. As we age, our bodies undergo changes that ...

  2. Pubertal outcome in a female with virilizing adrenocortical carcinoma

    Science.gov (United States)

    Breidbart, Emily; Cameo, Tamara; Garvin, James H.; Hibshoosh, Hanina

    2016-01-01

    Adrenocortical tumors are neoplasms that rarely occur in pediatric patients. Adrenocortical carcinoma (ACC) is even more uncommon, and is an aggressive malignancy with 5-year survival of 55% in a registry series. There is a lack of information on long-term endocrine outcome in survivors. We describe a 10-year follow-up in a patient who presented at 3 years 5 months with a 1-year history of axillary odor and 6 months’ history of pubic hair development with an increased clitoral size. Androgen levels were increased and a pelvic sonogram revealed a suprarenal mass of the left kidney. The tumor was successfully removed. At 6 years 11 months, androgen levels increased again. Workup for tumor recurrence was negative and the findings likely represented early adrenarche. The patient had menarche at an appropriate time and attained a height appropriate for her family. PMID:26812773

  3. Sexual Jealousy

    Directory of Open Access Journals (Sweden)

    David M. Buss

    2013-09-01

    Full Text Available Sexual jealousy is a basic emotion. Although it lacks a distinctive facial expression and is unlikely to solve problems of survival, it evolved because it solves adaptive problems of mating. Some adaptive functions are similar in men and women at one level of abstraction, such as warding off potential mate poachers and deterring relationship defection. Other functions are sex-differentiated, such as increasing paternity probability for men and monopolizing a mate's economic commitments for women. Dozens of studies have documented sex-differentiated design features of jealousy: The relative upset about sexual and emotional aspects of infidelity; processing speed and memorial recall of sexual and emotional infidelity cues; physiological distress to sexual and emotional infidelity cues; qualities of same-sex rivals that evoke jealousy, such as superior job prospects versus greater physical attractiveness; triggers of mate retention tactics; jealous interrogations following the discovery of infidelity; and whether an infidelity produces forgiveness or breakup. Although showing all the hallmarks of evolved functionality, sexual jealousy also leads to tremendous destruction, from humiliation to homicide. By these scientific theoretical and empirical criteria, sexual jealousy is properly considered not only "basic" but also "one of the most important emotions".

  4. Queer Pedagogies Out of Place and Time: Redrawing the Boundaries of Youth, Sexual and Gender Difference, and Education.

    Science.gov (United States)

    Marshall, Daniel

    2016-01-01

    For this contribution to the "Cartographies" section of the special issue on "Mapping Queer Bioethics," the author focuses on the concept of spatialized time as made material in the location of historical places, in particular as it relates to a reconsideration of approaches to Australian queer/LGBT youth education. Accordingly, the author employs historical maps as illustrative examples of spatialized time, reflecting on the relationships between historical knowledge and queer youth education.

  5. NELF knockout is associated with impaired pubertal development and subfertility

    Science.gov (United States)

    Quaynor, Samuel D.; Ko, Eun Kyung; Chorich, Lynn P.; Sullivan, Megan E.; Demir, Durkadin; Waller, Jennifer L.; Kim, Hyung-Goo; Cameron, Richard S.; Layman, Lawrence C.

    2015-01-01

    Puberty and reproduction require proper signaling of the hypothalamic-pituitary-gonadal axis controlled by gonadotropin-releasing hormone (GnRH) neurons, which arise in the olfactory placode region and migrate along olfactory axons to the hypothalamus. Factors adversely affecting GnRH neuron specification, migration, and function lead to delayed puberty and infertility. Nasal embryonic luteinizing hormone-releasing factor (NELF) is a predominantly nuclear protein. NELF mutations have been demonstrated in patients with hypogonadotropic hypogonadism, but biallelic mutations are rare and heterozygous NELF mutations typically co-exist with mutations in another gene. Our previous studies in immortalized GnRH neurons supported a role for NELF in GnRH neuron migration. To better understand the physiology of NELF, a homozygous Nelf knockout (KO) mouse model was generated. Our findings indicate that female Nelf KO mice have delayed vaginal opening but no delay in time to first estrus, decreased uterine weight, and reduced GnRH neuron number. In contrast, male mice were normal at puberty. Both sexes of mice had impaired fertility manifested as reduced mean litter size. These data support that NELF has important reproductive functions. The milder than expected phenotype of KO mice also recapitulates the human phenotype since heterozygous NELF mutations usually require an additional mutation in a second gene to result in hypogonadotropic hypogonadism. PMID:25731822

  6. Responses of testis, epididymis, and sperm of pubertal rats exposed to functionalized multiwalled carbon nanotubes.

    Science.gov (United States)

    Farombi, Ebenezer O; Adedara, Isaac A; Forcados, Gilead E; Anao, Osemudiamen O; Agbowo, Agatha; Patlolla, Anita K

    2016-05-01

    The present study investigated the response of testes, epididymides and sperm in pubertal Wistar rats following exposure to 0, 0.25, 0.5, 0.75, and 1.0 mg kg(-1) functionalized multi-walled carbon nanotubes (f-MWCNTs) for 5 days. The results showed that administration of (f-MWCNTs) significantly increased the activities of superoxide dismutase, catalase, and glutathione peroxidase in a dose-dependent manner in both testes and sperm compared with control group. Moreover, the significant decrease in the activity of glutathione-S-transferase and glutathione level was accompanied with significant elevation in the levels of hydrogen peroxide and malondialdehyde in both testes and sperm of (f-MWCNTs)-treated rats. The spermiogram of (f-MWCNTs)-treated rats indicated significant decrease in epididymal sperm number, sperm progressive motility, testicular sperm number and daily sperm production with elevated sperm abnormalities when compared with the control. Exposure to (f-MWCNTs) decreased plasma testosterone level and produced marked morphological changes including decreased geminal epithelium, edema, congestion, reduced spermatogenic cells and focal areas of tubular degeneration in the testes. The lumen of the epididymides contained reduced sperm cells and there was mild to severe hyperplasia epithelial cells lining the duct of the epididymis. Collectively, pubertal exposure of male rats to (f-MWCNTs) elicited oxidative stress response resulting in marked testicular and epididymides dysfunction.

  7. Association between CYP19A1 genotype and pubertal sagittal jaw growth

    Science.gov (United States)

    He, Shushu; Hartsfield, James K.; Guo, Yujiao; Cao, Yang; Wang, Si; Chen, Song

    2016-01-01

    Introduction Sagittal jaw growth is influenced during puberty by a ratio of androgens and estrogens. The CYP19A1 (formerly CYP19) gene encodes the cytochrome P450 enzyme aromatase (estrogen synthetase), which converts testosterone to estrogen. Genetic variations including single nucleotide polymorphisms might regulate CYP19A1 gene expression or the function of the aromatase protein and thus influence sagittal jaw growth. Methods The annual sagittal jaw growth in 92 pubertal orthodontic patients was determined by using pretreatment and posttreatment cephalometric radiographs. Single nucleotide polymorphisms rs2470144 and rs2445761 were genotyped and haplotypes constructed. Associations between genotypes or haplotypes and the annual sagittal growth were estimated by using JMP (version 9.0; SAS Institute, Cary, NC). Results Two single nucleotide polymorphisms were significantly associated with average differences in annual sagittal jaw growth in boys. Haplotype analysis demonstrated that haplotypes Trs2470144Trs2445761 and Crs2470144Trs2445761 had significant effects on annual sagittal maxillary growth and on mandibular growth in boys. No association was found in girls. Conclusions A quantitative trait locus that influences male pubertal sagittal jaw growth might exist in the CYP19A1 gene, and single nucleotide polymorphisms rs2470144 and rs2445761 might be inside this quantitative trait locus or be linked to it. PMID:23116507

  8. Vegetable and Fruit Intakes Are Associated with hs-CRP Levels in Pre-Pubertal Girls.

    Science.gov (United States)

    Navarro, Pilar; de Dios, Olaya; Jois, Asha; Gavela-Pérez, Teresa; Gorgojo, Lydia; Martín-Moreno, José M; Soriano-Guillen, Leandro; Garcés, Carmen

    2017-03-02

    The influence of diet on inflammation in children remains unclear. We aimed to analyze the influence of diet on high-sensitivity C-reactive protein (hs-CRP) levels in a pre-pubertal population free of other influences that may affect hs-CRP levels. We determined hs-CRP levels in 571 six- to eight-year-old children using an hs-CRP ELISA kit. Information on food and nutrient intake was obtained through a food-frequency questionnaire. Overall dietary quality was assessed using the Healthy Eating Index (HEI). We found that girls in the highest tertile of hs-CRP levels had a higher intake of saturated fatty acid, and lower intakes of fiber and vitamin E and a lower HEI score when compared to those in tertiles 1 and 2. We also observed a significant decrease in fruit and vegetable intakes by hs-CRP tertile. Factor analysis showed that a dietary pattern that was loaded most strongly with vegetable, fruit, fiber and vitamin A and E intakes correlated negatively (-0.132, p hs-CRP. No such association was found in boys. In conclusion, our data show that girls with a poorer quality diet show higher hs-CRP levels already at a pre-pubertal age.

  9. Specificity of Metabolic Syndrome Model Reproduction at Pubertal and Adult Male Rats

    Directory of Open Access Journals (Sweden)

    Bondarenko Larysa Borysivna

    2015-09-01

    Full Text Available Background and Aims: Comparative estimation of metabolic syndrome (MS mediated changes of blood, cardio-vascular system, liver, pancreas and kidneys morphologic structure in adult and pubertal rats. Materials and Methods: Wistar albino male rats of two age categories (young animals of 21 days age (50-70g and adults (160-180g were divided into 4 groups (8 animals in each: 1 - Control 1 (intact young rats; 2 - Control 2 (intact adult rats; 3 - MS3 (young rats with MS and 4 - MS4 (adult rats with MS. The metabolic syndrome model was induced by full replacement of drinking water with 20% fructose solution (200g/l. After 60 days of MS modeling, determination of rat hematological and serum biochemical parameters, glucose tolerance, blood pressure, liver rates of lipid peroxydation and chromatin DNA fragmentation, as well as morphological macroscopic and microscopic studies were carried out. Results: In pubertal rats, glucose tolerance, hypertension, blood clotting disturbances, DNAfragmentation and lipid peroxydation rates were affected more profoundly, while mature rats showed greater Pseudo Pelger-Huet anomaly development, serum cholesterol and lipoproteins increases, liver and kidney morphology changes. Conclusions: Our current data combined with previous results of other authors allow us to conclude that an animal model (Wistar rats of MS is quite easily obtained in a full age range, from juvenile to mature rats.

  10. Longitudinal pathways of sexual victimization, sexual self-esteem, and depression in women and men.

    Science.gov (United States)

    Krahé, Barbara; Berger, Anja

    2017-03-01

    This article presents a longitudinal analysis of the links between sexual assault victimization, depression, and sexual self-esteem by examining their cross-lagged paths among both men and women. Male and female college students (N = 2,425) in Germany participated in the study that comprised 3 data waves in their first, second, and third year of university, separated by 12-month intervals. Sexual assault victimization was assessed at Time 1 (T1) since the age of 14 and at Time 2 (T2) and Time 3 (T3) for the last 12 months. Depression and sexual self-esteem were measured at each wave. Random-intercept cross-lagged panel analyses, controlling for individual differences in depression and sexual self-esteem, showed that sexual assault at T1 predicted depression and lower sexual self-esteem at T2, and depression and lower self-esteem at T2 predicted sexual assault victimization at T3. In addition, significant paths were found from T1 depression to T2 sexual assault victimization and from T2 sexual assault victimization to depression at T3. Sexual victimization at T1 was indirectly linked to sexual victimization at T3 via depression at T2. Both depression and sexual self-esteem at T1 were indirectly linked to sexual victimization at T3. The paths did not differ significantly between men and women. Sexual assault victimization was shown to be a risk factor for both depression as a general mental health indicator and lowered sexual self-esteem as a specific outcome in the domain of sexuality. Moreover, depression and sexual self-esteem increased the vulnerability for sexual assault victimization, which has implications for prevention and intervention efforts. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

  11. Toward a New Understanding of Early Menarche: The Role of Environmental Stress in Pubertal Timing.

    Science.gov (United States)

    Wierson, Michelle; And Others

    1993-01-01

    Examined divorce and interparental conflict in light of theory that environmental stress may trigger early menarche in adolescents. Findings from 71 adolescent females and their mothers revealed that, compared to girls from intact families, those from divorced families had earlier onset of menarche. Higher maternal reports of interparental…

  12. Developmental trajectories of religiosity, sexual conservatism and sexual behavior among female adolescents.

    Science.gov (United States)

    Aalsma, Matthew C; Woodrome, Stacy E; Downs, Sarah M; Hensel, Devon J; Zimet, Gregory D; Orr, Don P; Fortenberry, J Dennis

    2013-12-01

    Understanding the role of socio-sexual cognitions and religiosity on adolescent sexual behavior could guide adolescent sexual health efforts. The present study utilized longitudinal data from 328 young women to assess the role of religion and socio-sexual cognitions on sexual behavior accrual (measuring both coital and non-coital sexual behavior). In the final triple conditional trajectory structural equation model, religiosity declined over time and then increased to baseline levels. Additionally, religiosity predicted decreased sexual conservatism and decreased sexual conservatism predicted increased sexual behavior. The final models are indicative of young women's increasing accrual of sexual experience, decreasing sexual conservatism and initial decreasing religiosity. The results of this study suggest that decreased religiosity affects the accrual of sexual experience through decreased sexual conservatism. Effective strategies of sexual health promotion should include an understanding of the complex role of socio-sexual attitudes with religiosity. Copyright © 2013 The Foundation for Professionals in Services for Adolescents. Published by Elsevier Ltd. All rights reserved.

  13. Sexual Orientation (For Parents)

    Science.gov (United States)

    ... Teaching Kids to Be Smart About Social Media Sexual Orientation KidsHealth > For Parents > Sexual Orientation Print A ... orientation is part of that process. What Is Sexual Orientation? The term sexual orientation refers to the ...

  14. Understanding Sexual Violence

    Science.gov (United States)

    Understanding Sexual Violence Fact Sheet 2014 Sexual violence refers to any sexual activity where consent is not obtained or freely given. Anyone can experience or perpetrate sexual violence. Most ...

  15. Predictors of sexual risk behaviour among adolescents from welfare institutions in Malaysia: a cross sectional study.

    Science.gov (United States)

    Farid, Nik Daliana Nik; Rus, Sulaiman Che'; Dahlui, Maznah; Al-Sadat, Nabilla; Aziz, Norlaili Abdul

    2014-01-01

    In welfare institutions, it is essential to address the health-related needs of adolescent populations who often engage in sexual activities. This study examines the association between individual and interpersonal factors concerning sexual risk behaviour (SRB) among adolescents in welfare institutions in Malaysia. Data were derived from a cross-sectional study of 1082 adolescents in 22 welfare institutions located across Peninsular Malaysia in 2009. Using supervised self-administered questionnaires, adolescents were asked to assess their self-esteem and to complete questions on pubertal onset, substance use, family structure, family connectedness, parental monitoring, and peer pressure. SRB was measured through scoring of five items: sexual initiation, age of sexual debut, number of sexual partners, condom use, and sex with high-risk partners. Multivariate logistic regression analysis was used to examine the various predictors of sexual risk behaviour. The study showed that 55.1% (95%CI = 52.0-58.2) of the total sample was observed to practice sexual risk behaviours. Smoking was the strongest predictor of SRB among male adolescents (OR = 10.3, 95%CI = 1.25-83.9). Among females, high family connectedness (OR = 3.13, 95%CI = 1.64-5.95) seemed to predict the behaviour. There were clear gender differences in predicting SRB. Thus, a gender-specific sexual and reproductive health intervention for institutionalised adolescents is recommended.

  16. Sexual activity after dysvascular lower extremity amputation.

    Science.gov (United States)

    Henderson, Alison W; Turner, Aaron P; Williams, Rhonda M; Norvell, Daniel C; Hakimi, Kevin N; Czerniecki, Joseph M

    2016-08-01

    This study examined the prevalence and correlates of sexual activity among individuals experiencing their first dysvascular lower extremity amputation. A prospective cohort was recruited from 4 Veterans Affairs Medical Centers. Of 198 potential participants who met inclusion criteria, 113 (57%) agreed to participate within 7 days of amputation (baseline) and 6 weeks, 4 months, and 12 months post-amputation; 105 completed the sexual activity items at baseline. Measures included self-reported frequency of sexual activity; desire for more or less sexual activity; importance of sexual activity to satisfaction with life; Patient Health Questionnaire-9; Locomotor Capability Index-5; pain intensity/frequency; quality of life. Depending on the time period post-amputation, 11%-24% reported engaging in any sexual activity, although a majority indicated that sexual activity is very important to their satisfaction with life. Frequency of sexual activity increased between 6 weeks and 4 and 12 months post-amputation. In univariate analyses, older age was associated with decreased sexual activity at all time points; at 4 and 12 months, greater mobility was associated with increased sexual activity. In multivariable models, mobility was associated with sexual activity at 4 and 12 months; age and race remained associated with sexual activity at 4 and 12 months, respectively. At all time points, frequency and importance of sexual activity were significantly associated with one another. Although a minority of individuals engaged in any sexual activity during the study period, it remained an important factor in overall satisfaction with life. Younger age and improved mobility were associated with increased sexual activity. Rehabilitation specialists are encouraged to address sexuality and, if relevant, incorporate it into rehabilitation goals. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

  17. Effect of high and low antral follicle count in pubertal beef heifers on in vitro fertilization (IVF)

    Science.gov (United States)

    Pubertal heifers can be classified between those with high (= 25) and low (= 15) antral follicle counts (AFC). The objective of this study was to determine oocyte development and maturation (e.g., fertility) in an in vitro fertilization (IVF) system for high and low AFC heifers. From a pool of 120...

  18. In vitro fertilization (IVF) from low or high antral follicle count pubertal beef heifers using semi-defined culture conditions

    Science.gov (United States)

    Antral follicle counts (AFC) vary among pubertal beef heifers. Our objective was to compare the in vitro maturation and fertilization of oocytes collected from low and high AFC heifers. Previously we reported results using serum-based IVF media and in this study report results using semi-defined m...

  19. Pre-menarche pubertal development following unique form of immigration: the case of girls adopted from China.

    Science.gov (United States)

    Tan, Tony Xing; Camras, Linda A

    2015-02-01

    Our study tested the hypothesis that drastic social-cultural change has an impact on girls' pre-menarche pubertal development. We focused on a unique group of Chinese immigrants who migrated out of China in infancy through international adoption. Our sample included 298 Chinese girls who were 7.3-11.1 years in 2011 (Mean = 8.8, SD = 0.9) and were adopted at 7-24 months (Mean = 12.6, SD = 3.4). We found that 34% showed at least one of four signs of pubertal development: Growth spurt, body fat increase, breast development, and body hair. Logistic regression analyses showed that the odds of growth spurt was raised by the girls' age in 2011, behavior problems in 2005, but lowered by the adoptive families' household income; the odds of body fat increase in 2011 was raised by the adopted Chinese girls' weight in 2007 and behavior problems in 2005, but was lowered by the adoptive mother's education level; the odds for breast development in 2011 was raised by the girls' age in 2011, weight in 2007, and behavior problems in 2009. For body hair, none of the factors predicted the odds. Prevalence of precocious puberty, based on the criterion of breast development before 8 years, was 3.5%. Overall, our study suggests that the pre-menarche pubertal development of adopted Chinese girls may be slightly advanced but also is affected by factors that affect non-adopted girls' pubertal development.

  20. Effect of Leaked Radiation from Microwave Oven on Bone Marrow of Male Rats in Pre and Post Pubertal Stage

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    G Jelodar

    2011-01-01

    Full Text Available Introduction: Increasing hematological diseases along with increased use of microwaves in different systems proposed possible correlation between them. Age of exposure to wave is also an important factor. This study was conducted to evaluate the effect of radiation leakaged from microwave oven on hemopoitic bone marrow cells at pre and post pubertal. Methods: Fourteen male mature (2 months old and 14 male immature rats(one month old were randomly divided in to four groups (control and test. Test groups were exposed, three times a day each time 30 min for 60 days, to microwaves produced by microwave oven. After sixty days, animals were sacrified and bone marrow samples were collected from femural bones. Percent of variose cells type and their morphology were evaluated in 500 cells of each smear. Results: exposure to microwave did not exert visible morphological alteration. In the immature experimental group significant decrease in percent of basophilic rubricyte, polychromatic rubricyte, meta rubricyte and all the erythroid cell types observed(P<0.05, whereas, meta myelocyte, notrophilic band, total myeloid cell types and prolifrative cells, other cell types and the myeloid/erythroid ratio significantly increased(P<0.05. In the mature group, however, a significant decrease in percent of meta rubricyte and myelocyte cells observed(P<0.05, although prolifrative cells and all other cell types were significantly increasing in this group. Conclusion: In conclusion, the radiation leaked from microwave oven in the experimental conditions had no effect on the morphology of hemopoitic bone marrow cells, though the number of these cells was altered especially in immature group.

  1. The effects on steroidogenesis and histopathology of adult male Japanese quails (Coturnix coturnix japonica) testis following pre-pubertal exposure to di(n-butyl) phthalate (DBP).

    Science.gov (United States)

    Bello, Umar M; Madekurozwa, Mary-Catherine; Groenewald, Herman B; Aire, Tom A; Arukwe, Augustine

    2014-11-01

    In the present study, we have investigated the effects of 30-day dietary (pre-pubertal) exposure to different doses (0 (control), 1, 10, 50, 200 and 400 mg/kg bodyweight/day) of di(n-butyl) phthalate (DBP) on Leydig cells of adult male Japanese quails by quantifying the transcript levels for P450 side-chain cleavage (p450scc), P450c17 (CYP17), and 3β- and 17β-hydroxysteroid dehydrogenase (hsd) using quantitative (real-time) polymerase chain reaction (qRT-PCR). In addition, the plasma testosterone levels were analysed using radioimmunoassay (RIA) and testis was examined for evidence of gross pathology and histopathology. Our data showed that pre-pubertal exposure to DBP produced alterations in testicular architecture as evident by poorly developed or mis-shaped testis, and altered spermatogenesis due to tubular degeneration and atrophy of seminiferous tubules especially in the high DBP dose (200 and 400 mg/kg) treated groups. In addition, DBP altered several key enzymes involved in testicular steroidogenesis pathways in an apparent dose-dependent manner. For example, biphasic effects of DBP were observed for P450scc and 3β-hsd mRNA, that were generally increasing at low dose 10 mg/kg, and thereafter, an apparent dose-dependent decrease between 50 and 400mg/kg. The steroidogenic acute regulatory (StAR) protein was at the lowest detectable limits and therefore not quantifiable. These effects did not parallel the non-significant changes observed for plasma testosterone levels. The present data is consistent with previous reports showing that DBP modulates Leydig cell steroidogenesis in several species, with a potential negative effect on reproduction in those avian species that are vulnerable to endocrine disrupting chemicals.

  2. Sex-specific mouse liver gene expression: genome-wide analysis of developmental changes from pre-pubertal period to young adulthood

    Directory of Open Access Journals (Sweden)

    Conforto Tara L

    2012-04-01

    Full Text Available Abstract Background Early liver development and the transcriptional transitions during hepatogenesis are well characterized. However, gene expression changes during the late postnatal/pre-pubertal to young adulthood period are less well understood, especially with regards to sex-specific gene expression. Methods Microarray analysis of male and female mouse liver was carried out at 3, 4, and 8 wk of age to elucidate developmental changes in gene expression from the late postnatal/pre-pubertal period to young adulthood. Results A large number of sex-biased and sex-independent genes showed significant changes during this developmental period. Notably, sex-independent genes involved in cell cycle, chromosome condensation, and DNA replication were down regulated from 3 wk to 8 wk, while genes associated with metal ion binding, ion transport and kinase activity were up regulated. A majority of genes showing sex differential expression in adult liver did not display sex differences prior to puberty, at which time extensive changes in sex-specific gene expression were seen, primarily in males. Thus, in male liver, 76% of male-specific genes were up regulated and 47% of female-specific genes were down regulated from 3 to 8 wk of age, whereas in female liver 67% of sex-specific genes showed no significant change in expression. In both sexes, genes up regulated from 3 to 8 wk were significantly enriched (p p Ihh; female-specific Cdx4, Cux2, Tox, and Trim24 and may contribute to the developmental changes that lead to global acquisition of liver sex-specificity by 8 wk of age. Conclusions Overall, the observed changes in gene expression during postnatal liver development reflect the deceleration of liver growth and the induction of specialized liver functions, with widespread changes in sex-specific gene expression primarily occurring in male liver.

  3. Sexual orientation differences in attitudes about sexuality, race, and gender.

    Science.gov (United States)

    Grollman, Eric Anthony

    2017-01-01

    Researchers have extensively documented sociodemographic predictors of race and gender attitudes, and the mechanisms through which such attitudes are formed and change. Despite its growing recognition as an important status characteristic, sexual orientation has received little attention as a predictor of Americans' race and gender attitudes. Using nationally representative data from the American National Election Survey 2012 Time Series Study, I compare heterosexuals' and lesbian, gay, and bisexual (LGB) people's attitudes about sexuality, race, and gender. For most attitudes, LGB people hold significantly more liberal attitudes about sexuality, race, and gender than do heterosexuals, even upon controlling for other powerful sociodemographic determinants of social attitudes. However, a substantial proportion of these sexual orientation gaps in attitudes - especially about race and gender - are explained by LGB people's relatively liberal political ideology. The findings provide evidence for the necessity of incorporating sexual orientation in future assessments of Americans' social and political attitudes.

  4. Gonadal function is associated with cardiometabolic health in pre-pubertal boys with Klinefelter syndrome.

    Science.gov (United States)

    Davis, S; Lahlou, N; Bardsley, M; Temple, M-C; Kowal, K; Pyle, L; Zeitler, P; Ross, J

    2016-11-01

    The most common sex chromosome aneuploidy, Klinefelter syndrome (KS), is associated with primary gonadal failure and increased morbidity and mortality from cardiometabolic disorders in adulthood. Children with KS also have a high prevalence of metabolic syndrome (MetS) features. To assess the relationship of gonadal and cardiometabolic function in children with KS, we evaluated serum hormones [gonadotropins, inhibin B (INHB), anti-mullerian hormone (AMH), total testosterone (TT)], and features of MetS (waist circumference, fasting lipid panel, fasting blood glucose (FBG), and blood pressure) in 93 pre-pubertal boys with KS age 4-12 years (mean 7.7 ± 2.5 years). The cohort was grouped by age and tanner stage, and biomarkers were compared to normal ranges. A total of 80% of this pre-pubertal cohort had ≥1 feature of metabolic syndrome (MetS) and 11% had ≥3 features of MetS. Risk of MetS was independent of age and body mass index. Sertoli cell dysfunction was common with 18% having an INHB below the normal range. A low INHB was associated with higher FBG, triglycerides, LDL, and lower HDL (p < 0.05). An INHB <50 ng/dL yielded a sensitivity of 83% and a specificity of 79% for having ≥3 features of MetS. INHB and AMH positively correlated with each other (p < 0.001), and high AMH was protective of MetS. TT was below the lower limit of normal in 49% of subjects, with mean values significantly lower than expected (3.3 ng/dL vs. 4.9 ng/dL, p < 0.0001), however, no convincing relationship between TT and MetS was seen. In conclusion, gonadal and cardiometabolic dysfunction are prevalent in pre-pubertal boys with KS. Although the relationship of testosterone deficiency and MetS is well-known, this study is the first to report an association between impaired Sertoli cell function and cardiometabolic risk.

  5. Betamethasone cream for the treatment of pre-pubertal labial adhesions.

    Science.gov (United States)

    Myers, Jeremy B; Sorensen, Carsten M; Wisner, Benjamin P; Furness, Peter D; Passamaneck, Michelle; Koyle, Martin A

    2006-12-01

    We evaluated the efficacy of 0.05% betamethasone cream for the treatment of pre-pubertal labial adhesions. We retrospectively reviewed the records of 19 children with labial adhesions who were treated with betamethasone cream from 6/2001 to 3/2003. Children were treated with 1 to 3 courses of twice-daily 0.05% betamethasone cream for 4 to 6 weeks. Successful lysis of adhesions was assessed by clinical exam or parental phone contact and outcomes were defined as: (1) success--complete separation of labia, (2) partial success--greater than 75% separation, (3) progression to surgical lysis, and (4) lost to follow-up. Nineteen patients with an average age of 58 months (range 12 to 132 months) were treated. Four of the 19 patients had never been treated previously and 1 had been treated previously with surgical lysis of adhesions only. Fourteen of the 19 patients had been previously treated with conjugated estrogen (Premarin) cream. Two of these fourteen patients had also undergone surgical lysis of adhesions. Severity of adhesions ranged from 33% to 99% labial closure. Betamethasone cream was successful in treating 13/19 (68%) pre-pubertal labial adhesions. Eleven (85%) of these 13 patients had complete resolution of labial adhesions with 1 course of treatment, 1 (7.5%) had resolution with 2 courses of treatment and 1 (7.5%) had resolution with 3 courses of treatment. One patient had a partial success with 3 courses of betamethasone cream. Two (11%) patients underwent surgical lysis of adhesion after 1 and 2 courses of betamethasone cream respectively. Three (16%) patients were lost to follow-up. Average follow-up was 7 months (range 1-24 months). No adverse outcomes or untoward effects were noted in any of the patients treated. Betamethasone 0.05% cream appears to be a safe and effective treatment of pre-pubertal labial adhesions as primary therapy or in patients that have failed previous therapies and it may avoid the undesirable side effects of breast budding and

  6. Timing of pollen release and stigma receptivity period of Piper vicosanum: New insights into sexual reproduction of the genus.

    Science.gov (United States)

    Valentin-Silva, Adriano; Coelho, Victor Peçanha de Miranda; Ventrella, Marília Contin; Vieira, Milene Faria

    2015-04-01

    Dichogamy is a common characteristic among angiosperms, including Piper species. In this genus, the tiny flowers are morphologically similar and have an asynchronous stamen development. However, there is no information on the duration of stigma receptivity and whether it overlaps with pollen release. To better understand mechanisms of floral function in Piper vicosanum, we provide a detailed characterization of the timing of pollen release from the four stamens and the period of stigma receptivity and exposure mode of the receptive areas. We investigated plants of a natural population in a semideciduous seasonal forest (Viçosa, Minas Gerais State, southeastern Brazil), based on chemical tests, light microscopy, and scanning electron microscopy analyses. Incomplete protogyny-a mechanism that favors outcrossing-was recorded. The period of stigma receptivity was long (14 d), and the sequential exposure and senescence of stigmatic papillae occurred gradually and in a basipetal direction. Pollen release began 2-6 d after the beginning of the pistillate phase, with an average pollen viability of 87.7%, during the bisexual flower phase. Pollen was released for up to 6 d and occurred in one stamen at a time. The fruit set observed in tests of self-pollination indicated self-compatibility. The gradual and sequential exposure of stigmatic papillae in P. vicosanum flowers is described here as the mechanism for the long duration of receptivity. Anther development and pollen release were also sequential. These findings are yet unreported reproductive characteristics of the genus and offer new perspectives for future studies on the floral biology of other Piper species. © 2015 Botanical Society of America, Inc.

  7. Foundations of Life-Long Sexual Health Literacy

    Science.gov (United States)

    Graf, Allyson Stella; Patrick, Julie Hicks

    2015-01-01

    Purpose: Sexual education in adolescence may represent the only formal sexual information individuals ever receive. It is unclear whether this early educational experience is sufficient to promote lifelong sexual health literacy. The purpose of this paper is to examine the influence of the timing and source of sexual knowledge on current safe sex…

  8. Identification of sexually dimorphic gene expression in brain tissue of the fish Leporinus macrocephalus through mRNA differential display and real time PCR analyses.

    Science.gov (United States)

    Alves-Costa, Fernanda A; Wasko, A P

    2010-03-01

    Differentially expressed genes in males and females of vertebrate species generally have been investigated in gonads and, to a lesser extent, in other tissues. Therefore, we attempted to identify sexually dimorphic gene expression in the brains of adult males and females of Leporinus macrocephalus, a gonochoristic fish species that presents a ZZ/ZW sex determination system, throughout a comparative analysis using differential display reverse transcriptase-PCR and real-time PCR. Four cDNA fragments were characterized, representing candidate genes with differential expression between the samples. Two of these fragments presented no significant identity with previously reported gene sequences. The other two fragments, isolated from male specimens, were associated to the gene that codes for the protein APBA2 (amyloid beta (A4) precursor protein-binding, family A, member 2) and to the Rab 37 gene, a member of the Ras oncogene family. The overexpression of these genes has been associated to a greater production of the beta-amyloid protein which, in turns, is the major factor that leads to Alzheimer's disease, and to the development of brain-tumors, respectively. Quantitative RT-PCR analyses revealed a higher Apba2 gene expression in males, thus validating the previous data on differential display. L. macrocephalus may represent an interesting animal model to the understanding of the function of several vertebrate genes, including those involved in neurodegenerative and cancer diseases.

  9. Genetic influences on adolescent sexual behavior: Why genes matter for environmentally oriented researchers.

    Science.gov (United States)

    Harden, K Paige

    2014-03-01

    There are dramatic individual differences among adolescents in how and when they become sexually active adults, and early sexual activity is frequently cited as a cause of concern for scientists, policymakers, and the general public. Understanding the causes and developmental impact of adolescent sexual activity can be furthered by considering genes as a source of individual differences. Quantitative behavioral genetics (i.e., twin and family studies) and candidate gene association studies now provide clear evidence for the genetic underpinnings of individual differences in adolescent sexual behavior and related phenotypes. Genetic influences on sexual behavior may operate through a variety of direct and indirect mechanisms, including pubertal development, testosterone levels, and dopaminergic systems. Genetic differences may be systematically associated with exposure to environments that are commonly treated as causes of sexual behavior (gene-environment correlation). Possible gene-environment correlations pose a serious challenge for interpreting the results of much behavioral research. Multivariate, genetically informed research on adolescent sexual behavior compares twins and family members as a form of quasi experiment: How do twins who differ in their sexual experiences differ in their later development? The small but growing body of genetically informed research has already challenged dominant assumptions regarding the etiology and sequelae of adolescent sexual behavior, with some studies indicating possible positive effects of teenage sexuality. Studies of Gene × Environment interaction may further elucidate the mechanisms by which genes and environments combine to shape the development of sexual behavior and its psychosocial consequences. Overall, the existence of heritable variation in adolescent sexual behavior has profound implications for environmentally oriented theory and research.

  10. Genetic Influences on Adolescent Sexual Behavior: Why Genes Matter for Environmentally-Oriented Researchers

    Science.gov (United States)

    Harden, K. Paige

    2013-01-01

    There are dramatic individual differences among adolescents in how and when they become sexually active adults, and “early” sexual activity is frequently cited as a cause of concern for scientists, policymakers, and the general public. Understanding the causes and developmental impact of adolescent sexual activity can be furthered by considering genes as a source of individual differences. Quantitative behavioral genetics (i.e., twin and family studies) and candidate gene association studies now provide clear evidence for the genetic underpinnings of individual differences in adolescent sexual behavior and related phenotypes. Genetic influences on sexual behavior may operate through a variety of direct and indirect mechanisms, including pubertal development, testosterone levels, and dopaminergic systems. Genetic differences may be systematically associated with exposure to environments that are commonly treated as causes of sexual behavior (gene-environment correlation). Possible gene-environment correlations pose a serious challenge for interpreting the results of much behavioral research. Multivariate, genetically-informed research on adolescent sexual behavior compares twins and family members as a form of “quasi-experiment”: How do twins who differ in their sexual experiences differ in their later development? The small but growing body of genetically-informed research has already challenged dominant assumptions regarding the etiology and sequelae of adolescent sexual behavior, with some studies indicating possible positive effects of teenage sexuality. Studies of gene × environment interaction may further elucidate the mechanisms by which genes and environments combine to shape the development of sexual behavior and its psychosocial consequences. Overall, the existence of heritable variation in adolescent sexual behavior has profound implications for environmentally-oriented theory and research. PMID:23855958

  11. Gender differences in sagittal standing alignment before pubertal peak growth: the importance of subclassification and implications for spinopelvic loading.

    Science.gov (United States)

    Dolphens, Mieke; Cagnie, Barbara; Vleeming, Andry; Vanderstraeten, Guy; Danneels, Lieven

    2013-12-01

    The aim of this study was to analyze gender differences in sagittal standing alignment at pre-peak height velocity age thereby applying a scientifically sound and practically oriented classification scheme for overall standing balance. The study population consisted of healthy boys (n = 639) and girls (n = 557) before pubertal peak growth. During subjects' habitual standing, sagittal plane measures of the spine, pelvis and lower limbs were collected using a clinical screening protocol. With each subject classified as one of three postural types (neutral, sway-back, or leaning-forward), differences in sagittal plane alignment were analyzed between sexes. The results revealed clear differences between genders in each of the postural types. Within the neutral and sway-back postural subgroups, boys presented more forward inclination of the trunk, more thoracic kyphosis and more pelvis backtilt compared with girls. Within the leaning-forward category, girls displayed more forward trunk lean, less thoracic kyphosis and more pelvic anteversion. A state of lumbar segmental hyperextension appeared to exist in female leaning-forward subjects. Our results reveal for the first time that sagittal standing alignment is different between prepubescent boys and girls when subjects are appropriately subclassified, and conversely represent a 'wash-out effect' when pooled. When the classification system is applied, gender-specificity in gravity line position is suggested, implying gender-related differences in lever arms and thus load. Present findings may add to our understanding of gender-specific biomechanical challenges posed by habitual posture, and may shed new light on sagittal standing alignment as a possible contributory factor in developmental spinal-pelvic disorders.

  12. Age, sex, and pubertal phase influence mentalizing about emotions and actions in adolescents.

    Science.gov (United States)

    Keulers, Esther H H; Evers, Elisabeth A T; Stiers, Peter; Jolles, Jelle

    2010-01-01

    This study examined (1) emotional versus cognitive developmental trajectories and (2) the influence of age-extrinsic factors (i.e., sex and puberty). Using a cross-sectional design, adolescents (N = 252) divided into four age-groups (ages 13, 15, 17, 19) performed two versions of a mentalizing task, about emotions and actions, as well as the Tower task. First, performance on all tasks improved linearly into late adolescence (age 19). Thus no differential trajectories were found for emotional versus cognitive development. Second, girls outperformed boys in mentalizing speed regarding both emotions and actions. In boys, a later pubertal phase was associated with increased mentalizing speed after controlling for age-group.

  13. Biology of the Sertoli Cell in the Fetal, Pubertal, and Adult Mammalian Testis.

    Science.gov (United States)

    Chojnacka, Katarzyna; Zarzycka, Marta; Mruk, Dolores D

    A healthy man typically produces between 50 × 10(6) and 200 × 10(6) spermatozoa per day by spermatogenesis; in the absence of Sertoli cells in the male gonad, this individual would be infertile. In the adult testis, Sertoli cells are sustentacular cells that support germ cell development by secreting proteins and other important biomolecules that are essential for germ cell survival and maturation, establishing the blood-testis barrier, and facilitating spermatozoa detachment at spermiation. In the fetal testis, on the other hand, pre-Sertoli cells form the testis cords, the future seminiferous tubules. However, the role of pre-Sertoli cells in this process is much less clear than the function of Sertoli cells in the adult testis. Within this framework, we provide an overview of the biology of the fetal, pubertal, and adult Sertoli cell, highlighting relevant cell biology studies that have expanded our understanding of mammalian spermatogenesis.

  14. How implicit theories of sexuality shape sexual and relationship well-being.

    Science.gov (United States)

    Maxwell, Jessica A; Muise, Amy; MacDonald, Geoff; Day, Lisa C; Rosen, Natalie O; Impett, Emily A

    2017-02-01

    How do people believe they can best maintain sexual satisfaction in their romantic relationships? In the current research, we draw upon the literature on implicit theories of relationships to develop and validate a scale examining 2 types of lay beliefs about how sexual satisfaction can be maintained over time. Individuals high in sexual growth beliefs think that sexual satisfaction is attained from hard work and effort, whereas individuals high in sexual destiny beliefs think that sexual satisfaction is attained through finding a compatible sexual partner. Across 6 studies (2 cross-sectional online studies, a 21-day daily experience study, 2 dyadic studies, and an experimental manipulation; N = 1,896), we find evidence that those higher in sexual growth beliefs experience higher relationship and sexual satisfaction, and have partners who are more satisfied. Conversely, the effects of sexual destiny beliefs on satisfaction are contingent upon signs of partner compatibility: When individuals high in sexual destiny beliefs experience greater sexual disagreements in their relationship, they experience lower relationship quality. These results are independent of general relationship implicit beliefs, providing evidence for the uniqueness of these 2 constructs and the importance of examining implicit beliefs in the domain of sexuality. Overall, these results provide novel evidence that individuals' lay beliefs about maintaining sexual satisfaction are important for understanding the quality of their sex lives and relationships. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

  15. Sexual Violence

    Centers for Disease Control (CDC) Podcasts

    2011-04-04

    This podcast discusses sexual violence - what it is, the long-term health problems it can contribute to, and tips to stop it before it begins.  Created: 4/4/2011 by National Center for Injury Prevention and Control (NCIPC).   Date Released: 4/4/2011.

  16. Sexual conflict

    NARCIS (Netherlands)

    Lessells, C.M.

    2012-01-01

    Parental care includes a wide variety of traits that enhance offspring development and survival. It is taxonomically widespread and is central to the maintenance of biodiversity through its close association with other phenomena such as sexual selection, life-history evolution, sex allocation, socia

  17. Adolescent Susceptibility to Peer Influence in Sexual Situations.

    Science.gov (United States)

    Widman, Laura; Choukas-Bradley, Sophia; Helms, Sarah W; Prinstein, Mitchell J

    2016-03-01

    One consistent predictor of adolescents' engagement in sexual risk behavior is their belief that peers are engaging in similar behavior; however, not all youth are equally susceptible to these peer influence effects. Understanding individual differences in susceptibility to peer influence is critical to identifying adolescents at risk for negative health outcomes. The purpose of this project was to identify predictors of susceptibility to peer influence using a novel performance-based measure of sexual risk taking. Participants were 300 early adolescents (Mage = 12.6 years; 53% female; 44% Caucasian) who completed (1) a pretest assessment of demographics, sexual attitudes, and hypothetical scenarios measuring the likelihood of engaging in sexual risk behavior and (2) a subsequent experimental procedure that simulated an Internet chat room in which youth believed that they were communicating with peers regarding these same hypothetical scenarios. In reality, these "peers" were computer-programmed e-confederates. Changes in responses to the sexual scenarios in the private pretest versus during the public chat room provided a performance-based measure of peer influence susceptibility. In total, 78% of youth provided more risky responses in the chat room than those in pretest. The most robust predictor of this change was gender, with boys significantly more susceptible to peer influence than girls. Significant interactions also were noted, with greater susceptibility among boys with later pubertal development and African-American boys. Results confirm that not all youth are equally susceptible to peer influence. Consistent with sexual script theory, boys evidence greater susceptibility to social pressure regarding sexual behavior than girls. Copyright © 2016 Society for Adolescent Health and Medicine. Published by Elsevier Inc. All rights reserved.

  18. Mental health problems of Iranian female adolescents and its association with pubertal development: a nationwide study.

    Science.gov (United States)

    Rabbani, Ali; Mahmoudi-Gharaei, Javad; Mohammadi, Mohammad Reza; Motlagh, Mohammad Esmaeil; Mohammad, Kazem; Ardalan, Gelayol; Maftoon, Farzaneh; Shahryari, Safiyeh; Khodaei, Shahnaz; Sotoudeh, Aria; Ziaaldini, Hassan; Kamali, Kobra; Motaghian, Molouk

    2012-01-01

    Mental health problems including emotional and behavioral problems during puberty may be under influence of different risk factors including cultures, living in urban or rural areas and ethnic factors which may vary between different countries. The main aim of this study is to investigate the profile of emotional and behavioral problems and the role of factors such as age, stage of puberty, ethnicity, rurality and living in urban area, as risk factors in Iranian girls. As a part of a large national study we evaluated the emotional and behavioral problems in different stages of puberty in a community sample of Iranian adolescent girls from public schools that were selected by clustered random sampling method. In all subjects, demographic characteristics, and pubertal stages were measured. Emotional and behavioral problems were evaluated using Strength and Difficulties Questionnaire (SDQ). The associations of age, pubertal development indices, socioeconomic and demographic factors with the behavioral problems were assessed. A total number of 4576 students enrolled the study and responded to the questions. The mean age of participants was 13.83 ± 2.19 years. The mean total score of difficulties in participants was 14.34 ± 5.81. According to these results 813 (17.8%) adolescents had total problem scores higher than Goodman's cutoff points and the most frequent problem domain was conduct problems (20.5%). According to the results the most related variable with the total difficulty score of SDQ were ethnicity, residency in urban areas and development of menstrual cycle respectively. The results of this study showed that the most correlated factors with mental health problems in Iranian girls during puberty are ethnicity, urbanity and development of menstrual cycle.

  19. Mental Health Problems of Iranian Female Adolescents and Its Association with Pubertal Development: A Nationwide Study

    Directory of Open Access Journals (Sweden)

    Aria Sotoudeh

    2012-03-01

    Full Text Available Mental health problems including emotional and behavioral problems during puberty may be under influence of different risk factors including cultures, living in urban or rural areas and ethnic factors which may vary between different countries. The main aim of this study is to investigate the profile of emotional and behavioral problems and the role of factors such as age, stage of puberty, ethnicity, rurality and living in urban area, as risk factors in Iranian girls. As a part of a large national study we evaluated the emotional and behavioral problems in different stages of puberty in a community sample of Iranian adolescent girls from public schools that were selected by clustered random sampling method. In all subjects, demographic characteristics, and pubertal stages were measured. Emotional and behavioral problems were evaluated using Strength and Difficulties Questionnaire (SDQ. The associations of age, pubertal development indices, socioeconomic and demographic factors with the behavioral problems were assessed. A total number of 4576 students enrolled the study and responded to the questions. The mean age of participants was 13.83 2.19 years. The mean total score of difficulties in participants was 14.34 5.81. According to these results 813 (17.8% adolescents had total problem scores higher than Goodmans cutoff points and the most frequent problem domain was conduct problems (20.5%. According to the results the most related variable with the total difficulty score of SDQ were ethnicity, residency in urban areas and development of menstrual cycle respectively. The results of this study showed that the most correlated factors with mental health problems in Iranian girls during puberty are ethnicity, urbanity and development of menstrual cycle.

  20. Relationships between urinary biomarkers of phytoestrogens, phthalates, phenols, and pubertal stages in girls.

    Science.gov (United States)

    Chakraborty, Tandra R; Alicea, Eilliut; Chakraborty, Sanjoy

    2012-01-01

    Phytoestrogens, phthalates, and phenols are estrogen-disrupting chemicals that have a pronounced effect at puberty. They are exogenous chemicals that are either plant-derived or man-made, and can alter the functions of the endocrine system and cause various health defects by interfering with the synthesis, metabolism, binding, or cellular responses of natural estrogens. Phytoestrogens, phthalates, and phenols are some of the potent estrogens detectable in urine. Phytoestrogens are plant-derived xenestrogens found in a wide variety of food products, like soy-based food, beverages, several fruits, and vegetables. Exposure to phytoestrogens can delay breast development and further lead to precocious puberty. The effect of phytoestrogens is mediated through estrogen receptors α and β or by binding with early immediate genes, such as jun and fos. Phthalates are multifunctional synthetic chemicals used in plastics, polyvinyl chloride products, cosmetics, hair spray, and children's toys. Phthalates have been shown to cause defeminization, thelarche, precocious puberty, and an increase in breast and pubic hair in pubertal girls. However, reports are also available that show no association of phthalates with precocious puberty in girls. Phthalates can act through a receptor-mediated signaling pathway or affect the production of luteinizing hormone and follicle-stimulating hormone that has a direct effect on estrogen formation. Phenols like bisphenol A are industrial chemicals used mainly in the manufacture of polycarbonates and plastic materials. Bisphenol A has been shown to cause precocious puberty and earlier menarche in pubertal girls. Reports suggest that the neurotoxic effect of bisphenol A can be mediated either by competing with estradiol for binding with estrogen receptors or via the ERK/NK-kappa or ERRγ pathway. This review demonstrates the effects of phytoestrogens, phthalates, and phenols on the development of girls during puberty.

  1. The molecular mechanisms of sexual orientation and gender identity.

    Science.gov (United States)

    Fisher, Alessandra D; Ristori, Jiska; Morelli, Girolamo; Maggi, Mario

    2017-08-25

    Differences between males and females are widely represented in nature. There are gender differences in phenotypes, personality traits, behaviors and interests, cognitive performance, and proneness to specific diseases. The most marked difference in humans is represented by sexual orientation and core gender identity, the origins of which are still controversial and far from being understood. Debates continue on whether sexual behavior and gender identity are a result of biological (nature) or cultural (nurture) factors, with biology possibly playing a major role. The main goal of this review is to summarize the studies available to date on the biological factors involved in the development of both sexual orientation and gender identity. A systematic search of published evidence was performed using Medline (from January 1948 to June 2017). Review of the relevant literature was based on authors' expertise. Indeed, different studies have documented the possible role and interaction of neuroanatomic, hormonal and genetic factors. The sexual dimorphic brain is considered the anatomical substrate of psychosexual development, on which genes and gonadal hormones may have a shaping effect. In particular, growing evidence shows that prenatal and pubertal sex hormones permanently affect human behavior. In addition, heritability studies have demonstrated a role of genetic components. However, a convincing candidate gene has not been identified. Future studies (e.i. genome wide studies) are needed to better clarify the complex interaction between genes, anatomy and hormonal influences on psychosexual development. Copyright © 2017. Published by Elsevier B.V.

  2. Sexuality and Sexual Dysfunctions in Bipolar Disorder

    Directory of Open Access Journals (Sweden)

    Zeynep Namli

    2016-12-01

    Full Text Available In the clinical course of bipolar disorder, there is a reduction in sexual will during depressive episodes and inappopriate sexual experiences and hypersexuality occurs during manic episodes. Up to now, studies focused on sexual side effects of drugs. Sexual violence, sexually transmitted diseases, contraception methods, unplanned pregnancies need to be assessed carefully in bipolar disorder patients. This review focused on sexuality and sexual dysfunctions in the course of bipolar disorder. [Psikiyatride Guncel Yaklasimlar - Current Approaches in Psychiatry 2016; 8(4.000: 309-320

  3. Pubertal Stage, Body Mass Index, and Cardiometabolic Risk in Children and Adolescents in Bogotá, Colombia: The Cross-Sectional Fuprecol Study

    Directory of Open Access Journals (Sweden)

    Robinson Ramírez-Vélez

    2017-06-01

    Full Text Available This study explored the association between pubertal stage and anthropometric and cardiometabolic risk factors in youth. A cross-sectional study was conducted in 2877 Colombian children and adolescents (9–17.9 years of age. Weight, height, and waist circumference were measured and body mass index (BMI was calculated. A biochemical study was performed to determine the cardiometabolic risk index (CMRI. Blood pressure was evaluated and pubertal stage was assessed with the Tanner criteria. Hierarchical multiple regression analyses were performed. The most significant variable (p < 0.05 in the prognosis of cardiometabolic risk was found to be the BMI in both boys and girls. In the case of girls, the pubertal stage was also a CMRI predictive factor. In conclusion, BMI was an important indicator of cardiovascular risk in both sexes. Pubertal stage was associated with cardiovascular risk only in the girls.

  4. The long-term impact of the MEMA kwa Vijana adolescent sexual and reproductive health intervention: effect of dose and time since intervention exposure.

    Directory of Open Access Journals (Sweden)

    Aoife M Doyle

    Full Text Available BACKGROUND: Despite recent decreases in HIV incidence in many sub-Saharan African countries, there is little evidence that specific behavioural interventions have led to a reduction in HIV among young people. Further and wider-scale decreases in HIV require better understanding of when behaviour change occurs and why. The MEMA kwa Vijana adolescent sexual and reproductive health intervention has been implemented in rural Mwanza, Tanzania since 1999. A long-term evaluation in 2007/8 found that the intervention improved knowledge, attitudes to sex and some reported risk behaviours, but not HIV or HSV2 prevalence. The aim of this paper was to assess the differential impact of the intervention according to gender, age, marital status, number of years of exposure and time since last exposure to the intervention. METHODS: In 2007, a cross-sectional survey was conducted in the 20 trial communities among 13,814 young people (15-30 yrs who had attended intervention or comparison schools between 1999 and 2002. Outcomes for which the intervention had an impact in 2001 or 2007 were included in this subgroup analysis. Data were analysed using cluster-level methods for stratified cluster-randomised trials, using interaction tests to determine if intervention impact differed by subgroup. RESULTS: Taking into account multiplicity of testing, concurrence with a priori hypotheses and consistency within the results no strong effect-modifiers emerged. Impact on pregnancy knowledge and reported attitudes to sex increased with years of exposure to high-quality intervention. CONCLUSIONS: The desirable long-term impact of the MEMA kwa Vijana intervention did not vary greatly according to the subgroups examined. This suggests that the intervention can have an impact on a broad cross-section of young people in rural Mwanza. TRIAL REGISTRATION: ClinicalTrials.gov NCT00248469.

  5. Sexual assault

    DEFF Research Database (Denmark)

    Larsen, M-L; Hilden, M; Lidegaard, Ø

    2015-01-01

    .4-2.2) or anogenital lesion (OR 1.5, 95% CI 1.1-2.0). Women aged 45 years or older were more likely to sustain a physical injury (OR 2.0, 95% CI 1.2-3.2) or an anogenital lesion (OR 2.1, 95% CI 1.4-3.2). CONCLUSIONS: Our results challenge the typical stereotype of a violent rape attack by a stranger, which......OBJECTIVE: To describe the victims of sexual assault and the circumstances in which the assaults occur. DESIGN: Descriptive case study. SETTING: Centre for Victims of Sexual Assault (CVSA), Rigshospitalet, Copenhagen, Denmark. POPULATION OR SAMPLE: A total of 2541 women attending CVSA from 2001...... to 2010. METHODS: All women attending CVSA underwent a standardised data collection procedure. Descriptive bivariate analysis and logistic regression analysis were performed. MAIN OUTCOME MEASURES: Associations between different assault characteristics and (1) the age of the victim and (2...

  6. Puberty and adolescent sexuality.

    Science.gov (United States)

    Fortenberry, J Dennis

    2013-07-01

    This article is part of a Special Issue "Puberty and Adolescence". Sexuality emerges as a major developmental element of puberty and the adolescent years that follow. However, connecting the sexuality that emerges with puberty and elements of adult sexuality is difficult because much adolescent sexuality research addresses the transition to partnered sexual behaviors (primarily coitus) and consequences such as unplanned pregnancy and sexually transmitted infections. This review proposes a framework of an expanded understanding of puberty and adolescent sexuality from the perspective of four hallmarks of adult sexuality: sexual desire; sexual arousal; sexual behaviors; and, sexual function. This approach thus addresses important gaps in understanding of the ontogeny of sex and the continuum of sexuality development from adolescence through the adult lifespan. Copyright © 2013 Elsevier Inc. All rights reserved.

  7. Sexuality and Young Children.

    Science.gov (United States)

    Honig, Alice Sterling

    2000-01-01

    Describes normal aspects of sexuality during the early years, including masturbation and children's fanciful sexual ideas. Presents inappropriately mature sexual knowledge as a danger sign of abuse. Discusses whether and what teachers/caregivers should tell children about sexuality, and notes the importance of teaching staff about sexual identity…

  8. Oxidative stress and the enzyme system of aldehyde catabolism in the muscle mitochondria of immobilized pubertal rats

    Directory of Open Access Journals (Sweden)

    Amjad Hamdallah

    2014-12-01

    Full Text Available The aim of the work is to find out peculiarities in manifestation of oxidative stress and to determine activity of enzymes, responsible for utilization of endogenous aldehydes in the mitochondrial fraction of the skeletal (femoral muscle in pubertal rats during immobilization stress. Our study has shown that differently directed changes in the activity of mitochondrial aldehyde dehydrogenases and aldehyde reductases occur in the pubertal immobilized rats, that limits the catabolism effectiveness as regards carbonyl products of free radical oxidation in the muscle cells. Corroboration of the effect under consideration is an increased level of protein free radical oxidation products in the mitochondria of the skeletal muscle. On the basis of the obtained data the authors draw a conclusion about an increased sensitivity of the skeletal muscle to the oxidative stress impact due to modulation in the state of enzyme system, responsible for utilization of endogenous aldehydes in the mitochondria.

  9. Metabolic Syndrome in Children and Adolescents: a Critical Approach Considering the Interaction between Pubertal Stage and Insulin Resistance.

    Science.gov (United States)

    Reinehr, Thomas

    2016-01-01

    Pediatricians increasingly diagnose the metabolic syndrome (MetS) in recent years to describe cardiovascular risk and to guide management of the obese child. However, there is an ongoing discussion about how to define the MetS in childhood and adolescence. Since insulin resistance-the major driver of MetS-is influenced by pubertal stage, it is questionable to use definitions for MetS in children and adolescents that do not take into account pubertal status. A metabolic healthy status in prepubertal stage does not predict a metabolic healthy status during puberty. Furthermore, cardiovascular risk factors improve at the end of puberty without treatment. However, having a uniform internationally accepted definition of the MetS for children and adolescents would be very helpful for the description of populations in different studies. Therefore, the concept of MetS has to be revisited under the influence of puberty stage.

  10. Sexual Harassment: A problem unresolved!

    Directory of Open Access Journals (Sweden)

    N Vanishree

    2013-01-01

    Full Text Available Sexual harassment is a highly prevalent form of gender-based discrimination and sexual exploitation in the workplace and academic environment. In the dental field, there are a few studies regarding sexual harassment among the patients, professors and claims of their students. There is a silence of consent surrounding sexual harassment. It is clearly an issue about which the practicing dentists need to be informed in order to provide knowledgeable assessment and treatment for all patients. Dentists also have a role in advocacy, expert consultation or testimony, research and prevention through education and training. It is a fact that sexual harassment is very commonly encountered by almost everyone especially women. It is the most unresolved and under recognized problem of today especially when professionals are concerned. Preventing sexual harassment requires a considerable investment of time and personnel. This paper reviews the topic of sexual harassment as a problem from its legal aspects and recommendations for further steps to resolve this issue in dentistry.

  11. Sexual behaviors in children: evaluation and management.

    Science.gov (United States)

    Kellogg, Nancy D

    2010-11-15

    Sexual behaviors in children are common, occurring in 42 to 73 percent of children by the time they reach 13 years of age. Developmentally appropriate behavior that is common and frequently observed in children includes trying to view another person's genitals or breasts, standing too close to other persons, and touching their own genitals. Sexual behaviors become less common, less frequent, or more covert after five years of age. Sexual behavior problems are defined as developmentally inappropriate or intrusive sexual acts that typically involve coercion or distress. Such behaviors should be evaluated within the context of other emotional and behavior disorders, socialization difficulties, and family dysfunction, including violence, abuse, and neglect. Although many children with sexual behavior problems have a history of sexual abuse, most children who have been sexually abused do not develop sexual behavior problems. Children who have been sexually abused at a younger age, who have been abused by a family member, or whose abuse involved penetration are at greater risk of developing sexual behavior problems. Although age-appropriate behaviors are managed primarily through reassurance and education of the parent about appropriate behavior redirection, sexual behavior problems often require further assessment and may necessitate a referral to child protective services for suspected abuse or neglect.

  12. Employer's Guide: A Time for Action on Sexual Harassment in the Workplace = Guide de L'Employeur: Les Enjeux du Harcelement Sexuel au Travail.

    Science.gov (United States)

    Ontario Women's Directorate, Toronto.

    Harassment, like other forms of violence against women, is not a new problem. It is not a problem that will just go away, but it can be stopped. This guide is designed for use by organizations and employers to help them develop policies and implement programs in their workplace that address workplace sexual harassment. It focuses on Canadian…

  13. Sexuality in Older Adults

    Science.gov (United States)

    ... org editorial staffSexual Dysfunction (Women)Read Article >>WomenSexual Dysfunction (Women)Learn about the symptoms, causes and treatment of sexual dysfunction disorders.April 2014September 2000familydoctor.org editorial staff ...

  14. Rethinking Sexual Citizenship.

    Science.gov (United States)

    Richardson, Diane

    2017-04-01

    Over the last two decades sexuality has emerged as a key theme in debates about citizenship, leading to the development of the concept of sexual citizenship. This article reviews this literature and identifies four main areas of critical framing: work that contests the significance of sexuality to citizenship; critiques that focus on the possibilities and limitations of mobilising the language of citizenship in sexual politics; analyses of sexual citizenship in relation to nationalisms and border making; and literature that critically examines western constructions of sexuality and sexual politics underpinning understandings of sexual citizenship. In order to progress the field theoretically, the article seeks to extend critiques of sexual citizenship focusing on two key aspects of its construction: the sexual citizen-subject and spaces of sexual citizenship. It argues for a critical rethink that encompasses a de-centring of a 'western-centric' focus in order to advance understandings of how sexual citizenship operates both in the Global North and South.

  15. Child Sexual Abuse

    Science.gov (United States)

    Sexual abuse is one form of child abuse. It includes a wide range of actions between a child ... to children or pressuring them for sex is sexual abuse. Using a child for pornography is also sexual ...

  16. Toddlers and Sexual Behavior

    Science.gov (United States)

    ... com Pediatrics Common Questions, Quick Answers Toddlers and Sexual Behavior Donna D'Alessandro, M.D. Lindsay Huth, ... behavioral problem or sexual abuse. What kind of sexual behaviors are okay? Masturbation in toddlers is usually ...

  17. Your Sexual Health

    Science.gov (United States)

    ... AQ FREQUENTLY ASKED QUESTIONS FAQ072 WOMEN’S HEALTH Your Sexual Health • What causes sexual problems in women? • What are the types of sexual problems that affect women? • What are desire problems? • ...

  18. Loss of vitamin D receptor signaling from the mammary epithelium or adipose tissue alters pubertal glandular development.

    Science.gov (United States)

    Johnson, Abby L; Zinser, Glendon M; Waltz, Susan E

    2014-10-15

    Vitamin D₃ receptor (VDR) signaling within the mammary gland regulates various postnatal stages of glandular development, including puberty, pregnancy, involution, and tumorigenesis. Previous studies have shown that vitamin D₃ treatment induces cell-autonomous growth inhibition and differentiation of mammary epithelial cells in culture. Furthermore, mammary adipose tissue serves as a depot for vitamin D₃ storage, and both epithelial cells and adipocytes are capable of bioactivating vitamin D₃. Despite the pervasiveness of VDR in mammary tissue, individual contributions of epithelial cells and adipocytes, as well as the VDR-regulated cross-talk between these two cell types during pubertal mammary development, have yet to be investigated. To assess the cell-type specific effect of VDR signaling during pubertal mammary development, novel mouse models with mammary epithelial- or adipocyte-specific loss of VDR were generated. Interestingly, loss of VDR in either cellular compartment accelerated ductal morphogenesis with increased epithelial cell proliferation and decreased apoptosis within terminal end buds. Conversely, VDR signaling specifically in the mammary epithelium modulated hormone-induced alveolar growth, as ablation of VDR in this cell type resulted in precocious alveolar development. In examining cellular cross-talk ex vivo, we show that ligand-dependent VDR signaling in adipocytes significantly inhibits mammary epithelial cell growth in part through the vitamin D₃-dependent production of the cytokine IL-6. Collectively, these studies delineate independent roles for vitamin D₃-dependent VDR signaling in mammary adipocytes and epithelial cells in controlling pubertal mammary gland development.

  19. Pubertal and adult windows of susceptibility to a high animal fat diet in Trp53-null mammary tumorigenesis.

    Science.gov (United States)

    Zhu, Yirong; Aupperlee, Mark D; Zhao, Yong; Tan, Ying Siow; Kirk, Erin L; Sun, Xuezheng; Troester, Melissa A; Schwartz, Richard C; Haslam, Sandra Z

    2016-12-13

    Premenopausal breast cancer is associated with increased animal fat consumption among normal weight, but not overweight women (Farvid et al., 2014). Our previous findings in obesity-resistant BALB/c mice similarly showed promotion of carcinogen-induced mammary tumorigenesis by a diet high in saturated animal fat (HFD). This effect was specific to pubertal versus adult HFD. This study identifies the effects of HFD during puberty versus adulthood in Trp53-null transplant BALB/c mice and investigates its mechanism of enhancing tumorigenesis. Either pubertal or adult HFD is sufficient to increase incidence of Trp53-null mammary tumors. Puberty-restricted HFD exposure promoted tumor cell proliferation, increased angiogenesis, and increased recruitment of total and M2 macrophages in epithelial tumors. Adult-restricted exposure to HFD similarly increased proliferation, angiogenesis, recruitment of total and M2 macrophages, and additionally reduced apoptosis. Adult HFD also increased incidence of spindle cell carcinomas resembling claudin-low breast cancer, and thus adult HFD in the Trp53-null transplantation system may be a useful model for human claudin low breast cancer. Importantly, these results on Trp53-null and our prior studies on DMBA-induced mammary tumorigenesis demonstrate a pubertal window of susceptibility to the promotional effects of HFD, indicating the potential of early life dietary intervention to reduce breast cancer risk.

  20. Selection of reference genes for quantitative real-time PCR expression studies of microdissected reproductive tissues in apomictic and sexual Boechera

    Directory of Open Access Journals (Sweden)

    Amiteye Samuel

    2011-08-01

    Full Text Available Abstract Background Apomixis, a natural form of asexual seed production in plants, is considered to have great biotechnological potential for agriculture. It has been hypothesised that de-regulation of the sexual developmental pathway could trigger apomictic reproduction. The genus Boechera represents an interesting model system for understanding apomixis, having both sexual and apomictic genotypes at the diploid level. Quantitative qRT-PCR is the most extensively used method for validating genome-wide gene expression analyses, but in order to obtain reliable results, suitable reference genes are necessary. In this work we have evaluated six potential reference genes isolated from a 454 (FLX derived cDNA library of Boechera. RNA from live microdissected ovules and anthers at different developmental stages, as well as vegetative tissues of apomictic and sexual Boechera, were used to validate the candidates. Results Based on homologies with Arabidopsis, six genes were selected from a 454 cDNA library of Boechera: RPS18 (Ribosomal sub protein 18, Efalpha1 (Elongation factor 1 alpha, ACT 2 (Actin2, UBQ (polyubiquitin, PEX4 (Peroxisomal ubiquitin conjugating enzyme and At1g09770.1 (Arabidopsis thaliana cell division cycle 5. Total RNA was extracted from 17 different tissues, qRT-PCRs were performed, and raw Ct values were analyzed for primer efficiencies and gene ratios. The geNorm and normFinder applications were used for selecting the most stable genes among all tissues and specific tissue groups (ovule, anthers and vegetative tissues in both apomictic and sexual plants separately. Our results show that BoechRPS18, BoechEfα1, BoechACT2 and BoechUBQ were the most stable genes. Based on geNorm, the combinations of BoechRPS18 and BoechEfα1 or BoechUBQ and BoechEfα1 were the most stable in the apomictic plant, while BoechRPS18 and BoechACT2 or BoechUBQ and BoechACT2 performed best in the sexual plant. When subgroups of tissue samples were analyzed

  1. Relationships between urinary biomarkers of phytoestrogens, phthalates, phenols, and pubertal stages in girls

    Directory of Open Access Journals (Sweden)

    Chakraborty TR

    2012-01-01

    Full Text Available Tandra R Chakraborty1, Eilliut Alicea1, Sanjoy Chakraborty21Department of Biology, Adelphi University, One South Avenue, Garden City; 2Department of Biological Sciences, New York City College of Technology, New York, NY, USAAbstract: Phytoestrogens, phthalates, and phenols are estrogen-disrupting chemicals that have a pronounced effect at puberty. They are exogenous chemicals that are either plant-derived or man-made, and can alter the functions of the endocrine system and cause various health defects by interfering with the synthesis, metabolism, binding, or cellular responses of natural estrogens. Phytoestrogens, phthalates, and phenols are some of the potent estrogens detectable in urine. Phytoestrogens are plant-derived xenestrogens found in a wide variety of food products, like soy-based food, beverages, several fruits, and vegetables. Exposure to phytoestrogens can delay breast development and further lead to precocious puberty. The effect of phytoestrogens is mediated through estrogen receptors α and β or by binding with early immediate genes, such as jun and fos. Phthalates are multifunctional synthetic chemicals used in plastics, polyvinyl chloride products, cosmetics, hair spray, and children's toys. Phthalates have been shown to cause defeminization, thelarche, precocious puberty, and an increase in breast and pubic hair in pubertal girls. However, reports are also available that show no association of phthalates with precocious puberty in girls. Phthalates can act through a receptor-mediated signaling pathway or affect the production of luteinizing hormone and follicle-stimulating hormone that has a direct effect on estrogen formation. Phenols like bisphenol A are industrial chemicals used mainly in the manufacture of polycarbonates and plastic materials. Bisphenol A has been shown to cause precocious puberty and earlier menarche in pubertal girls. Reports suggest that the neurotoxic effect of bisphenol A can be mediated either by

  2. Hormones and female sexuality

    OpenAIRE

    2003-01-01

    Introduction In contrast to animal species in which linear relationships exist between hormonal status and sexual behaviour sexuality in human population is not determined so simply by the level of sexual steroids. The article analyses female sexuality in the light of hormonal status. Administration of sexual steroids during pregnancy and sexual differentiation High doses of gestagens, especially those with high androgen activity, widely used against miscarriages may lead to tomboys, but with...

  3. Biology of Sexual Dysfunction

    OpenAIRE

    MN, Anil Kumar; Pai, NB; Rao, S; Rao, TSS; Goyal, N.

    2009-01-01

    Sexual activity is a multifaceted activity, involving complex interactions between the nervous system, the endocrine system, the vascular system and a variety of structures that are instrumental in sexual excitement, intercourse and satisfaction. Sexual function has three components i.e., desire, arousal and orgasm. Many sexual dysfunctions can be categorized according to the phase of sexual response that is affected. In actual clinical practice however, sexual desire, arousal and orgasmic di...

  4. Bias Due to Correlation Between Times-at-Risk for Infection in Epidemiologic Studies Measuring Biological Interactions Between Sexually Transmitted Infections: A Case Study Using Human Papillomavirus Type Interactions.

    Science.gov (United States)

    Malagón, Talía; Lemieux-Mellouki, Philippe; Laprise, Jean-François; Brisson, Marc

    2016-12-15

    The clustering of human papillomavirus (HPV) infections in some individuals is often interpreted as the result of common risk factors rather than biological interactions between different types of HPV. The intraindividual correlation between times-at-risk for all HPV infections is not generally considered in the analysis of epidemiologic studies. We used a deterministic transmission model to simulate cross-sectional and prospective epidemiologic studies measuring associations between 2 HPV types. When we assumed no interactions, the model predicted that studies would estimate odds ratios and incidence rate ratios greater than 1 between HPV types even after complete adjustment for sexual behavior. We demonstrated that this residual association is due to correlation between the times-at-risk for different HPV types, where individuals become concurrently at risk for all of their partners' HPV types when they enter a partnership and are not at risk when they are single. This correlation can be controlled in prospective studies by restricting analyses to susceptible individuals with an infected sexual partner. The bias in the measured associations was largest in low-sexual-activity populations, cross-sectional studies, and studies which evaluated infection with a first HPV type as the exposure. These results suggest that current epidemiologic evidence does not preclude the existence of competitive biological interactions between HPV types. © The Author 2016. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  5. Sexual Health

    Directory of Open Access Journals (Sweden)

    Dr. Christine Boyce

    2009-04-01

    Full Text Available This month two general practitioners (GPs describe their approach to sexual health consultations.The issue of a sexually active adolescent demonstrates some differences in legislation pertaining tothe requirement to involve the authorities, although in essence the young person can expect thesame response from these practitioners in two different health care systems. On the other hand apatient at risk of sexually transmitted infections is more likely to be referred to a specialistGenitourinary clinic in the UK although the protocols for screening and education are largely similar.Equally patients who are HIV positive can expect to receive the bulk of their care from specialistclinics in both countries.Midwives are the main stay of antenatal services in Australia and the UK with general practitionersminimally involved in routine cases. Also home births are a negigible proportion of all deliveries ineither country. When patients opt for a home birth our authors expressed the view that GPsgenerally do not have the skills or experience to be the main health professional in attendance.Therefore such births are primarily managed by midwives as the key health care professional. Thefocus of General practitioners is primarily to ensure that the patient is making an informed decisionabout delivering her baby at home. The GP is therefore still in an influential position to assist thewoman in making a decision about where to give birth. As a point of difference in Australia a homebirth would result in out of pocket expences for the mother.The views expressed below are those of the authors and do not necessarily reflect health policy orpractice elsewhere in their countries. However we believe they offer an interesting perspective ontheir health care systems and commend the article to our readers.Please

  6. A Cultural Sexuality or a Sexual Culture?

    NARCIS (Netherlands)

    Vandermeersch, Patrick

    1990-01-01

    P. Vandermeersch, A Cultural Sexuality or a Sexual Culture? In: F. VAN DE VIJVER & G. HUTSCHEMAEKERS (ed.), The Investigation of Culture. Current Issues in Cultural Psychology, Tilburg, Tilburg University Press, 1990, 43-58.

  7. Genetic factors modulate the impact of pubertal androgen excess on insulin sensitivity and fertility.

    Directory of Open Access Journals (Sweden)

    Abigail R Dowling

    Full Text Available Polycystic ovary syndrome (PCOS is the most common endocrine disorder of reproductive age women. The syndrome is caused by a combination of environmental influences and genetic predisposition. Despite extensive efforts, the heritable factors contributing to PCOS development are not fully understood. The objective of this study was to test the hypothesis that genetic background contributes to the development of a PCOS-like reproductive and metabolic phenotype in mice exposed to excess DHEA during the pubertal transition. We tested whether the PCOS phenotype would be more pronounced on the diabetes-prone C57BL/6 background than the previously used strain, BALB/cByJ. In addition, we examined strain-dependent upregulation of the expression of ovarian and extra-ovarian candidate genes implicated in human PCOS, genes containing known strain variants, and genes involved with steroidogenesis or insulin sensitivity. These studies show that there are significant strain-related differences in metabolic response to excess androgen exposure during puberty. Additionally, our results suggest the C57BL/6J strain provides a more robust and uniform experimental platform for PCOS research than the BALB/cByJ strain.

  8. Association between Physical Activity and Cardiovascular Risk in Chinese Youth Independent of Age and Pubertal Stage

    Directory of Open Access Journals (Sweden)

    Lau Joseph TF

    2010-06-01

    Full Text Available Abstract Background Childhood and adolescence are critical periods of habit formation with substantial tracking of lifestyle and cardiovascular risk into adulthood. There are various guidelines on recommended levels of physical activity in youth of school-age. Despite the epidemic of obesity and diabetes in China, there is a paucity of data in this regard in Chinese youth. We examined the association of self-reported level of physical activity and cardiovascular risk in Hong Kong Chinese youth of school-age. Methods This was a cross-sectional study conducted in 2007-8 in a school setting with 2119 Hong Kong Chinese youth aged 6-20 years. Physical activity level was assessed using a validated questionnaire, CUHK-PARCY (The Chinese University of Hong Kong: Physical Activity Rating for Children and Youth. A summary risk score comprising of waist circumference, blood pressure, fasting plasma glucose and lipids was constructed to quantify cardiovascular risk. Results In this cohort, 21.5% reported high level of physical activity with boys being more active than girls (32.1% versus 14.1%, p Conclusion Self-reported level of physical activity is associated with cardiovascular risk factors in Chinese youth after adjusting for sex and pubertal stage.

  9. Evaluation of GnRH analogue testing in diagnosis and management of children with pubertal disorders

    Directory of Open Access Journals (Sweden)

    Hemchand K Prasad

    2012-01-01

    Full Text Available Context: Gonadotrophin releasing hormone (GnRH stimulation test is pivotal in the assessment of children with pubertal disorders. However, lack of availability and high cost often result in the test falling into disfavor. We routinely use the GnRH analogue stimulation test as an alternative at our center. Aim: To present the data on children with endocrine disorders who underwent GnRH agonist stimulation test in pediatric endocrine clinic of a tertiary care referral hospital. Setting and Design: Pediatric endocrine clinic of a tertiary care referral hospital. Retrospective analysis of case records. Materials and Methods: The details pertaining to clinical and radiological parameters and hormonal tests were retrieved from case records of 15 children who underwent GnRH agonist stimulation test from May 2010 to April 2011. Results: Indications for testing with GnRH analogue were evaluation of delayed puberty, diagnosis of precocious puberty, assessment of hormonal suppression in treatment of precocious puberty and micropenis in two, nine, three and one cases, respectively. The results of the test and clinical and radiological parameters were in concordance. The test was also crucial in diagnosing the onset of central precocious puberty in two children with congenital adrenal hyperplasia. Conclusion: GnRH agonist test is a convenient, safe test that can be performed on an out-patient basis and can help the clinicians in the correct diagnosis and appropriate treatment of various puberty-related disorders.

  10. Evolution of fat oxidation during exercise in obese pubertal boys: clinical implications.

    Science.gov (United States)

    Zunquin, Gautier; Theunynck, Denis; Sesboue, Bruno; Arhan, Pierre; Bougle, Dominique

    2009-02-15

    In this study, we examined fat oxidation rates during exercise in obese pubescent boys. Three groups of pubescent boys (16 pre-pubescent, Tanner's stage I; 16 pubescent, Tanner's stage III; and 14 post-pubescent, Tanner's stage V) performed a graded test on a leg cycle ergometer. The first step of the test was fixed at 30 W and power was gradually increased by 20 W every 3.5 min. Oxygen consumption (VO(2)) and carbon dioxide production (VCO(2)) were determined as the means of measurements during the last 30 s of each step, which allowed us to calculate fat oxidation rates versus exercise intensity. Between 20 and 50% of peak oxygen consumption (VO(2peak)), fat oxidation rate in relative values (mg . min(-1) . kg FFM(-1)) decreased continuously with pubertal development. In the same way, the maximum rate of fat oxidation occurred at a lower percentage of VO(2peak) (pre-pubescent: 49.47 +/- 1.62%; pubescent: 47.43 +/- 1.26%; post-pubescent: 45.00 +/- 0.97%). Our results confirm that puberty is responsible for a decrease in fat free mass capacities to use fat during exercise. The results suggest that post-pubescent obese boys need to practise physical activity at a lower intensity than pre-pubescent boys to enhance lipolysis and diminish adipose tissue and the consequences of obesity.

  11. The evolution of the female sexual response concept: Treatment implications

    Directory of Open Access Journals (Sweden)

    Damjanović Aleksandar

    2013-01-01

    Full Text Available Sexual dysfunctions have been the most prevalent group of sexual disorders and include a large number of populations of both sexes. The research of sexual behavior and treatment of women with sexual distress arises many questions related to differences in sexual response of men and women. The conceptualization of this response in modern sexology has changed over time. The objective of our paper was to present the changes and evolution of the female’s sexual response concept in a summarized and integrated way, to analyze the expanded and revised definitions of the female sexual response as well as implications and recommendations of new approaches to diagnostics and treatment according to the established changes. The lack of adequate empirical basis of the female sexual response model is a critical question in the literature dealing with this issue. Some articles report that linear models demonstrate more correctly and precisely the sexual response of women with normal sexual functions in relation to women with sexual dysfunction. Modification of this model later resulted in a circular model which more adequately presented the sexual response of women with sexual function disorder than of women with normal sexual function. The nonlinear model of female sexual response constructed by Basson incorporates the value of emotional intimacy, sexual stimulus and satisfaction with the relationship. Female functioning is significantly affected by multiple psychosocial factors such as satisfaction with the relationship, self-image, earlier negative sexual experience, etc. Newly revised, expanded definitions of female sexual dysfunction try to contribute to new knowledge about a highly contextual nature of woman’s sexuality so as to enhance clinical treatment of dysfunctions. The definitions emphasize the evaluation of the context of women’s problematic sexual experiences.

  12. The evolution of the female sexual response concept: treatment implications.

    Science.gov (United States)

    Damjanović, Aleksandar; Duisin, Dragana; Barisić, Jasmina

    2013-01-01

    Sexual dysfunctions have been the most prevalent group of sexual disorders and include a large number of populations of both sexes.The research of sexual behavior and treatment of women with sexual distress arises many questions related to differences in sexual response of men and women. The conceptualization of this response in modern sexology has changed over time.The objective of our paper was to present the changes and evolution of the female's sexual response concept in a summarized and integrated way, to analyze the expanded and revised definitions of the female sexual response as well as implications and recommendations of new approaches to diagnostics and treatment according to the established changes.The lack of adequate empirical basis of the female sexual response model is a critical question in the literature dealing with this issue. Some articles report that linear models demonstrate more correctly and precisely the sexual response of women with normal sexual functions in relation to women with sexual dysfunction. Modification of this model later resulted in a circular model which more adequately presented the sexual response of women with sexual function disorder than of women with normal sexual function.The nonlinear model of female sexual response constructed by Basson incorporates the value of emotional intimacy, sexual stimulus and satisfaction with the relationship. Female functioning is significantly affected by multiple psychosocial factors such as satisfaction with the relationship, self-image, earlier negative sexual experience, etc. Newly revised, expanded definitions of female sexual dysfunction try to contribute to new knowledge about a highly contextual nature of woman's sexuality so as to enhance clinical treatment of dysfunctions.The definitions emphasize the evaluation of the context of women's problematic sexual experiences.

  13. Tattoos, piercing, and sexual behaviors in young adults.

    Science.gov (United States)

    Nowosielski, Krzysztof; Sipiński, Adam; Kuczerawy, Ilona; Kozłowska-Rup, Danuta; Skrzypulec-Plinta, Violetta

    2012-09-01

    Body piercing and tattooing are accepted by a growing number of teenagers and young adults as a way of self-expressing. Some authors suggest association between body piercings/tattoos and early sexual initiation, higher number of sexual partners, or risky sexual behaviors. The aim of the study was to evaluate sexual behaviors among young adults with body modifications (BMs)--tattoos and piercings. One hundred twenty young healthy adults, ages between 20 and 35, were included in the population study. The study group was divided into three subgroups: controls (N = 60), adults with tattoos (N = 28), and adults with piercings (N = 32). The research instrument was a self-prepared questionnaire containing 59 questions assessing socioepidemiological parameters, sexual behaviors, incidents of sexual harassment in the past, and self-attractiveness evaluation, as well as questions concerning tattoos and piercings. Socioepidemiological variables and sexual behaviors were compared between subgroups. To assess and describe the correlation between having BM--tattoos and piercing--and sexual behaviors in the population of young adults by using the logistic regression model. Adults with BMs have had their first intercourse statistically earlier and were more sexually active compared with controls. There were no statically significant differences in sexual orientation, sexual preferences, engaging in risky sexual behaviors, frequency of masturbation, and history of sexual abuse between the groups. In contrast, the frequency of sexual intercourses was statistically higher and oral sex was more likely to be a dominant sexual activity in adults with BM compared with controls. The multivariate logistic model revealed that adults with BM were four times less likely to participate in religious practices and twice more likely to have early sexual initiation. Having BM is associated with early sexual initiation and more liberal attitudes toward sexual behaviors but not with engaging in

  14. Multidimensional sexual perfectionism.

    Science.gov (United States)

    Stoeber, Joachim; Harvey, Laura N; Almeida, Isabel; Lyons, Emma

    2013-11-01

    Perfectionism is a multidimensional personality characteristic that can affect all areas of life. This article presents the first systematic investigation of multidimensional perfectionism in the domain of sexuality exploring the unique relationships that different forms of sexual perfectionism show with positive and negative aspects of sexuality. A sample of 272 university students (52 male, 220 female) completed measures of four forms of sexual perfectionism: self-oriented, partner-oriented, partner-prescribed, and socially prescribed. In addition, they completed measures of sexual esteem, sexual self-efficacy, sexual optimism, sex life satisfaction (capturing positive aspects of sexuality) and sexual problem self-blame, sexual anxiety, sexual depression, and negative sexual perfectionism cognitions during sex (capturing negative aspects). Results showed unique patterns of relationships for the four forms of sexual perfectionism, suggesting that partner-prescribed and socially prescribed sexual perfectionism are maladaptive forms of sexual perfectionism associated with negative aspects of sexuality whereas self-oriented and partner-oriented sexual perfectionism emerged as ambivalent forms associated with positive and negative aspects.

  15. Hormones and female sexuality

    Directory of Open Access Journals (Sweden)

    Bjelica Artur L.

    2003-01-01

    Full Text Available Introduction In contrast to animal species in which linear relationships exist between hormonal status and sexual behaviour sexuality in human population is not determined so simply by the level of sexual steroids. The article analyses female sexuality in the light of hormonal status. Administration of sexual steroids during pregnancy and sexual differentiation High doses of gestagens, especially those with high androgen activity, widely used against miscarriages may lead to tomboys, but without differences in sexual orientation. However, it has been observed that the frequency of bisexual and lesbian women is higher in women with congenital adrenogenital syndrome. Hormones sexual desire and sexuality during menstrual cycle It has been established that sexual desire, autoeroticism and sexual fantasies in women depend on androgen levels. There are a lot of reports claiming that sexual desire varies during the menstrual cycle. Hormonal contraception and sexuality Most patients using birth control pills present with decreased libido. But, there are reports that progestagens with antiandrogenic effect in contraceptive pills do not affect sexual desire. Hormonal changes in peri- and postmenopausal period and sexuality Decreased levels of estrogen and testosterone in older women are associated with decreased libido, sensitivity and erotic stimuli. Sexuality and hormone replacement therapy Hormonal therapy with estrogen is efficient in reference to genital atrophy, but not to sexual desire. Really increased libido is achieved using androgens. Also, therapy with dehydroepiandrosterone (DHEA and tibolone have positive effects on female libido. Conclusion Effect of sexual steroids on sexual sphere of women is very complex. The association between hormones and sexuality is multidimensional, as several hormones are important in regulation of sexual behaviour. Still, it should be pointed out that sexuality is in the domain of hormonal, emotional

  16. Impact of a new mandatory reporting law on reporting and identification of child sexual abuse: A seven year time trend analysis.

    Science.gov (United States)

    Mathews, Ben; Lee, Xing Ju; Norman, Rosana E

    2016-06-01

    Child sexual abuse is widespread and difficult to detect. To enhance case identification, many societies have enacted mandatory reporting laws requiring designated professionals, most often police, teachers, doctors and nurses, to report suspected cases to government child welfare agencies. Little research has explored the effects of introducing a reporting law on the number of reports made, and the outcomes of those reports. This study explored the impact of a new legislative mandatory reporting duty for child sexual abuse in the State of Western Australia over seven years. We analyzed data about numbers and outcomes of reports by mandated reporters, for periods before the law (2006-2008) and after the law (2009-2012). Results indicate that the number of reports by mandated reporters of suspected child sexual abuse increased by a factor of 3.7, from an annual mean of 662 in the three year pre-law period to 2448 in the four year post-law period. The increase in the first two post-law years was contextually and statistically significant. Report numbers stabilized in 2010-2012, at one report per 210 children. The number of investigated reports increased threefold, from an annual mean of 451 in the pre-law period to 1363 in the post-law period. Significant decline in the proportion of mandated reports that were investigated in the first two post-law years suggested the new level of reporting and investigative need exceeded what was anticipated. However, a subsequent significant increase restored the pre-law proportion, suggesting systemic adaptive capacity. The number of substantiated investigations doubled, from an annual mean of 160 in the pre-law period to 327 in the post-law period, indicating twice as many sexually abused children were being identified.

  17. 'The darkest times of my life': Recollections of child abuse among forced migrants persecuted because of their sexual orientation and gender identity.

    Science.gov (United States)

    Alessi, Edward J; Kahn, Sarilee; Chatterji, Sangeeta

    2016-01-01

    Numerous studies demonstrate that lesbian, gay, bisexual, and transgender (LGBT) children and youth are likely to experience abuse by peers, parents, and other adults and that these experiences correlate with a host of mental health problems. However, there is little understanding of the experiences of LGBT children and youth living in countries where social and legal protections for sexual and gender minorities are limited or nonexistent. This qualitative study used thematic analysis to explore the child and adolescent abuse experiences and their impact on the pre-migration mental health of LGBT forced migrants. We analyzed 26 interviews with individuals who obtained refugee or asylee status in the United States or Canada on the basis of sexual orientation or gender identity. Participants originated from countries in Asia, Africa, the Caribbean, Eastern Europe, Latin America, and the Middle East. Analysis revealed the following themes: abuse by parents and caregivers, abuse by peers and school personnel, having nowhere to turn, and dealing with psychological distress. Findings indicate that participants experienced severe verbal, physical, and sexual abuse throughout childhood and adolescence and that this abuse occurred at home, in school, and in the community. Furthermore, there were no resources or sources of protection available to them. Participants linked their abuse to subjective experiences of depression, anxiety, and traumatic stress, as well as suicidal ideation and suicide attempts. We conclude with implications for refugee adjudication practices, mental health care, and international policy.

  18. Prevalence of Sexual Experience and Initiation of Sexual Intercourse Among Adolescents, Rakai District, Uganda, 1994-2011

    DEFF Research Database (Denmark)

    Santelli, John S; Song, Xiaoyu; Larsen Holden, Inge Kristine

    2015-01-01

    PURPOSE: The purpose of the study was to identify risk factors and time trends for sexual experience and sexual debut in rural Uganda. METHODS: Using population-based, longitudinal data from 15- to 19-year olds in Rakai, Uganda, we examined temporal trends in the prevalence of sexual experience...... youth in Rakai was associated with social factors particularly school enrollment. Changes in these social factors also appear to influence change over time in sexual experience....

  19. Direct and indirect measures of sexual maturity preferences differentiate subtypes of child sexual abusers.

    Science.gov (United States)

    Schmidt, Alexander F; Gykiere, Kim; Vanhoeck, Kris; Mann, Ruth E; Banse, Rainer

    2014-04-01

    To aid risk assessment, management, and treatment planning it is essential to assess child sexual abusers' deviant sexual interests (DSI) and preferences (DSP) for sex with children. However, measurement of DSI/DSP is fraught with psychometric problems. In consequence, research interest has shifted to latency-based indirect measures as a measurement approach to complement self-report and physiological assessment. Utilizing the Explicit and Implicit Sexual Interest Profile (EISIP)-a multimethod approach consisting of self-report, viewing time, and Implicit Association Test (IAT) DSI/DSP measures-we replicated phallometric DSI/DSP differences between child sexual abuser subgroups in a sample of intrafamilial, extrafamilial, and child pornography offenders. DSI/DSP was associated with recidivism risk, offense-behavioral measures of pedophilic interest, and sexual fantasizing. It also negatively correlated with antisociality. Distinguishing between child sexual abuser subtypes and being related to recidivism risk, the EISIP is a useful tool for sexual offender assessments.

  20. Sexuality and Violence.

    Science.gov (United States)

    Sanctuary, Gerald

    The author examines specific manifestations of violence in relation to sexuality: (1) forcible rape rate; (2) war atrocities; (3) sexual violence in prisons; and (4) pornography. Drawing much from Hannah Arendt's book on violence, he views sexual violence as symptomatic of a lack of sexual power, not a sign of its possession. The causes are seen…

  1. Sexuality and Down Syndrome

    Science.gov (United States)

    ... 4602 [email protected] Down Syndrome What Is Down Syndrome? Down Syndrome Facts Myths & Truths Preferred Language Guide Q& ... Shop NDSS Home » Resources » Wellness » Sexuality » Sexuality & Down Syndrome Sexuality & Down Syndrome Human sexuality encompasses an individual's self-esteem, ...

  2. Sexual risk taking behaviour

    DEFF Research Database (Denmark)

    Buttmann, Nina; Nielsen, Ann; Munk, Christian

    2011-01-01

    Sexual habits and risky sexual behaviour strongly affect public health. Available data indicate that sexually transmitted infections are increasing in many EU countries. Changes in the epidemiology of sexually transmitted diseases across Europe are among other factors suggested to be driven by ch...

  3. Sexuality Talk During Adolescent Health Maintenance Visits

    Science.gov (United States)

    Alexander, Stewart C.; Fortenberry, J. Dennis; Pollak, Kathryn I.; Bravender, Terrill; Davis, J. Kelly; Østbye, Truls; Tulsky, James A.; Dolor, Rowena J.; Shields, Cleveland G.

    2015-01-01

    Importance Physicians may be important sources of sexuality information and preventive services, and one-on-one confidential time during health maintenance visits is recommended to allow discussions of sexual development, behavior, and risk reduction. However, little is known about the occurrence and characteristics of physician-adolescent discussions about sexuality. Objective To examine predictors of time spent discussing sexuality, level of adolescent participation, and physician and patient characteristics associated with sexuality discussions during health maintenance visits by early and middle adolescents. Design, Setting, and Participants Observational study of audio-recorded conversations between 253 adolescents (mean age, 14.3 years; 53% female; 40% white; 47% African American) and 49 physicians (82% pediatricians; 84% white; 65% female; mean age, 40.9 years; mean [SD] duration in practice, 11.8 [8.7] years) coded for sexuality content at 11 clinics (3 academic and 8 community-based practices) located throughout the Raleigh/Durham, North Carolina, area. Main Outcomes and Measures Total time per visit during which sexuality issues were discussed. Results One hundred sixty-five (65%) of all visits had some sexual content within it. The average time of sexuality talk was 36 seconds (35% 0 seconds; 30% 1-35 seconds; and 35% ≥36 seconds). Ordinal logistic regression (outcome of duration: 0, 1-35, or ≥36 seconds), adjusted for clustering of patients within physicians, found that female patients (odds ratio [OR] = 2.58; 95% CI, 1.53-4.36), older patients (OR = 1.37; 95% CI, 1.13-1.65), conversations with explicit confidentiality discussions (OR = 4.33; 95% CI, 2.58-7.28), African American adolescents (OR = 1.58; 95% CI, 1.01-2.48), and longer overall visit (OR = 1.07; 95% CI, 1.03-1.11) were associated with more sexuality talk, and Asian physicians were associated with less sexuality talk (OR = 0.13; 95% CI, 0.08-0.20). In addition, the same significant

  4. Sexuality talk during adolescent health maintenance visits.

    Science.gov (United States)

    Alexander, Stewart C; Fortenberry, J Dennis; Pollak, Kathryn I; Bravender, Terrill; Davis, J Kelly; Ostbye, Truls; Tulsky, James A; Dolor, Rowena J; Shields, Cleveland G

    2014-02-01

    Physicians may be important sources of sexuality information and preventive services, and one-on-one confidential time during health maintenance visits is recommended to allow discussions of sexual development, behavior, and risk reduction. However, little is known about the occurrence and characteristics of physician-adolescent discussions about sexuality. To examine predictors of time spent discussing sexuality, level of adolescent participation, and physician and patient characteristics associated with sexuality discussions during health maintenance visits by early and middle adolescents. Observational study of audio-recorded conversations between 253 adolescents (mean age, 14.3 years; 53% female; 40% white; 47% African American) and 49 physicians (82% pediatricians; 84% white; 65% female; mean age, 40.9 years; mean [SD] duration in practice, 11.8 [8.7] years) coded for sexuality content at 11 clinics (3 academic and 8 community-based practices) located throughout the Raleigh/Durham, North Carolina, area. Total time per visit during which sexuality issues were discussed. RESULTS One hundred sixty-five (65%) of all visits had some sexual content within it. The average time of sexuality talk was 36 seconds (35% 0 seconds; 30% 1-35 seconds; and 35% ≥ 36 seconds). Ordinal logistic regression (outcome of duration: 0, 1-35, or ≥ 36 seconds), adjusted for clustering of patients within physicians, found that female patients (odds ratio [OR] = 2.58; 95% CI, 1.53-4.36), older patients (OR = 1.37; 95% CI, 1.13-1.65), conversations with explicit confidentiality discussions (OR = 4.33; 95% CI, 2.58-7.28), African American adolescents (OR = 1.58; 95% CI, 1.01-2.48), and longer overall visit (OR = 1.07; 95% CI, 1.03-1.11) were associated with more sexuality talk, and Asian physicians were associated with less sexuality talk (OR = 0.13; 95% CI, 0.08-0.20). In addition, the same significant associations between adolescent, physician, and visit characteristics were

  5. Hormonal predictors of women's extra-pair vs. in-pair sexual attraction in natural cycles: Implications for extended sexuality.

    Science.gov (United States)

    Grebe, Nicholas M; Emery Thompson, Melissa; Gangestad, Steven W

    2016-02-01

    In naturally cycling women, Roney and Simmons (2013) examined hormonal correlates of their desire for sexual contact. Estradiol was positively associated, and progesterone negatively associated, with self-reported desire. The current study extended these findings by examining, within a sample of 33 naturally cycling women involved in romantic relationships, hormonal correlates of sexual attraction to or interests in specific targets: women's own primary partner or men other than women's primary partner. Women's sexual interests and hormone (estradiol, progesterone, and testosterone) levels were assessed at two different time points. Whereas estradiol levels were associated with relatively greater extra-pair sexual interests than in-pair sexual interests, progesterone levels were associated with relatively greater in-pair sexual interests. Both hormones specifically predicted in-pair sexual desire, estradiol negatively and progesterone positively. These findings have implications for understanding the function of women's extended sexuality - their sexual proceptivity and receptivity outside the fertile phase, especially during the luteal phase.

  6. Predicting Resilience in Sexually Abused Adolescents

    Science.gov (United States)

    Williams, Javonda; Nelson-Gardell, Debra

    2012-01-01

    This research examined factors that predicted resilience in sexually abused adolescents. Using Bronfenbrenner's Process-Person-Context-Time (PPCT) ecological model, this study considered the proximal and distal factors that would contribute to adolescents' reactions to sexual victimization. This correlational study used hierarchical regression…

  7. How Mothers Perceive Their Own Sexuality

    Science.gov (United States)

    Trice-Black, Shannon

    2009-01-01

    For women, the transition to motherhood is often a time period filled with excitement, changes, and challenges. Mothers often face changes in their own sexuality in their adjustment to motherhood. The majority of research on the sexual changes during motherhood has focused on the first year postpartum of mothers and has emphasized biological,…

  8. Predicting Resilience in Sexually Abused Adolescents

    Science.gov (United States)

    Williams, Javonda; Nelson-Gardell, Debra

    2012-01-01

    This research examined factors that predicted resilience in sexually abused adolescents. Using Bronfenbrenner's Process-Person-Context-Time (PPCT) ecological model, this study considered the proximal and distal factors that would contribute to adolescents' reactions to sexual victimization. This correlational study used hierarchical regression…

  9. Sexuality and Islam.

    Science.gov (United States)

    Dialmy, Abdessamad

    2010-06-01

    This paper deals with three major questions: (1) What are the sexual norms defined by the sacred texts (Koran and Sunna)? (2) What are the sexual practices currently observed among Moslems? (3) To which extent are current sexual practices of Moslems dissociated from Islamic sexual norms? Sexual standards in Islam are paradoxical: on the one hand, they allow and actually are an enticement to the exercise of sexuality but, on the other hand, they discriminate between male and female sexuality, between marital and pre- or extramarital sexuality, and between heterosexuality and homosexuality. Men are given more rights with regard to the expression of their sexuality; women are forbidden to have extramarital sex (with their slaves) and both genders to have homosexual relationships. The combination of these paradoxical standards with modernisation leads to the current back and forth swing of sexual practices between repression and openness. Partial modernisation leads to greater sexual tolerance. But restrictive sexual standards have gathered strength and have become idealised as a result of the current radicalisation of Islam. This swing of the pendulum between repression and openness is illustrated by phenomena such as public harassment, premarital sexuality, female pleasure, prostitution, and homosexuality. Currently, Islam is not any more the only reference which provides guidance concerning sexual practices but secularisation of sexual laws is still politically unthinkable today. So the only solution is to achieve reform in the name of Islam, through the reinterpretation of repressive holy texts.

  10. Transcript levels of genes implicated in steroidogenesis in the testes and fat tissue in relation to androstenone accumulation in fat of pubertal pigs.

    Science.gov (United States)

    Robic, A; Feve, K; Riquet, J; Prunier, A

    2016-10-01

    The present study was performed to measure messenger RNA levels of steroidogenic enzymes in testes and fat tissue and determine whether they are related to fat androstenone level. Real-time polymerase chain reaction experiments were performed on 26 testes and 12 adipose tissue samples from pubertal boars using 21 genes. The absence of significant correlations between fat androstenone and the transcriptional activity of the SRD5A2 and SRD5A3 genes but the high correlation coefficient with that of the SRD5A1 gene (r = 0.62, P fat concentration of androstenone (0.57 fat is related to the production in testes of androstenone and more generally to all sex steroids. Altogether, our data are in favor of a preponderant role of AKR1C-pig6 instead of HSD17B3 for testicular synthesis of steroids. Concerning fat tissue, our data do not support a significant de novo biosynthesis of steroids in porcine adipose tissues. The presence of transcripts coding for steroid enzymes, especially those of AKR1C-pig6, suggests that steroids can be transformed. None of transcript abundance was related to androstenone accumulation (P > 0.1). Therefore, steroids synthesized elsewhere can be transformed in fat tissue but synthesis of androstenone is unlikely.

  11. Body trunk fat and insulin resistance in post-pubertal obese adolescents

    Directory of Open Access Journals (Sweden)

    Luana Caroline dos Santos

    Full Text Available CONTEXT AND OBJECTIVE: Insulin resistance is a metabolic disorder commonly associated with excess body fat accumulation that may increase chronic disease risk. The present study was undertaken to evaluate the relationship between body composition and insulin resistance among obese adolescents. DESIGN AND SETTING: Cross-sectional study, at the Adolescence Center, Pediatric Department, Universidade Federal de São Paulo. METHODS: Body composition was assessed using dual-energy X-ray absorptiometry. Dietary intake was evaluated using a three-day dietary record. The biochemical evaluation comprised glucose, insulin, serum lipid, leptin and ghrelin measurements. Insulin resistance was calculated by means of the homeostasis model assessment of insulin resistance (HOMA-IR. RESULTS: Forty-nine post-pubertal obese adolescents participated in the study: 12 boys and 37 girls of mean age 16.6 (1.4 years and mean body mass index (BMI of 35.0 (3.9 kg/m². The mean glucose, insulin and HOMA values were 90.3 (6.4 mg/dl, 16.6 (8.1 µIU/ml and 3.7 (1.9, respectively. Hyperinsulinemia and insulin resistance were observed in 40.2% and 57.1% of the subjects, respectively. Adolescents with insulin resistance had higher BMI and body trunk fat. There was a trend towards higher leptin concentration in obese individuals with insulin resistance. Insulin resistance was positively correlated with body trunk fat, BMI, body fat mass (kg, leptin and body fat percentage. Furthermore, there was a negative correlation between HOMA-IR and lean body mass. The body composition predicted 30% of the HOMA-IR levels, according to linear regression models. CONCLUSION: Body trunk fat was significantly associated with insulin resistance, demonstrating the clinical importance of abdominal obesity during adolescence.

  12. Effectiveness of vitamin E as treatment of primary dysmenorrhea in pubertal adolescents

    Directory of Open Access Journals (Sweden)

    Wagito

    2011-01-01

    Full Text Available Background Primary dysmenorrhea is a common complaint among adolescents. Absenteeism from work and school are associated with the severity of symptoms. Vitamin E is an alternative treatment for primary dysmenorrhea. Objective To evaluate the effectiveness of vitamin E as a treatment of primary dysmenorrhea. Methods We conducted a randomized, double-blind, controlled trial from August to October 2009. We included female adolescents with primary dysmenorrhea in this study. Subjects were divided into 2 groups by simple randomization. Each group received either 200 units of vitamin E or a placebo twice daily, beginning two days before menstruation and continuing until the third day of menstruation. Treatment was repeated for three menstrual cycles. Subjects recorded the severity and duration of pain in a daily diary. Data was analyzed using Chi-square, Mann-Whitney U-test, and independent t-test. Results One hundred-sixteen primary dysmenorrhea subjects enrolled in our study. By simple randomization, they were divided into two groups of 58 subjects each. There were no statistically significant differences between the two groups in the severity and duration of pain before the start of treatment and after 1 month of treatment. After treatment for 2 months and 3 months, there were statistically significant differences in pain severity (P=0.013, 95%CI -0.54 to -0.11; and P=0.0001, 95%CI -0.67 to -0.26, respectively and pain duration (P=0.025, 95%CI -0.65 to -0.07 and P=0.007, 95%CI -0.75 to -0.12, respectively between the 2 groups. Conclusion Vitamin E was effective in treatment of primary dysmenorrhea in pubertal adolescents after 2 and 3 months of treatment. [Paediatr Indones. 2011;51:41-6].

  13. Sex-dependent consequences of pre-pubertal gonadectomy: Social behavior, stress and ethanol responsivity.

    Science.gov (United States)

    Kim, Esther U; Spear, Linda P

    2016-01-01

    Alcohol consumption can be enhanced or moderated by sensitivity to its aversive and appetitive properties, including positive social outcomes. These differences emerge post-pubertally, suggesting a potential role of gonadal hormones. To determine the role of gonadal hormones in sensitivity to the social impairing and social context-related attenuations in the aversive effects of ethanol, prepubertal male and female rats were gonadectomized (GX) or sham (SH) operated on postnatal day (P) 25, or left non-manipulated (NM). In adulthood (P70), rats were restrained for 90 min prior to challenge with 0.0 or 1.0 g/kg ethanol and social interaction (SI) testing. At P77, groups of 4 same-sex littermates from the same surgical condition were given access to a supersaccharin (SS) solution (3% sucrose, 0.125% saccharin), followed by an intraperitoneal injection of ethanol (0.0, 0.50, 1.0, 1.5 g/kg). Intakes of SS were examined 24h later for expression of conditioned taste aversions. Acute stress prior to SI testing increased frequency of play fighting in both sexes, whereas there were no GX effects on this measure, social investigation nor contact. GX, however, decreased baseline social preference (a social anxiety-like effect) in males, while inducing anxiolytic-like increases in baseline social preference in females. The social drinking test revealed that females developed ethanol conditioned taste aversions at a lower dose relative to males, regardless of surgical condition. These findings suggest a potential role for gonadal hormones in moderating social-anxiety like behaviors but not sensitivity to the social impairing effects of ethanol or ethanol's aversive consequences in a social context.

  14. A Possible Link Between the Pubertal Growth of Girls and Ovarian Cancer in Their Daughters

    Science.gov (United States)

    BARKER, DAVID J. P.; OSMOND, CLIVE; THORNBURG, KENT L.; KAJANTIE, EERO; ERIKSSON, JOHAN G.

    2017-01-01

    At puberty, the distance between the iliac crests of the female pelvis, measured by the intercristal and interspinous diameters, increases rapidly. This is mainly controlled by estrogens. We have followed up 6,370 women who were born in Helsinki during 1934–1944, and whose mothers’ pelvic bones were measured during routine antenatal care. We have previously reported that women whose mothers had larger intercristal diameters had higher rates of breast cancer. We postulated that large intercristal diameters are markers of high circulating concentrations of estrogen, which are established at puberty, persist through reproductive life and cause genetic instability in differentiating breast cells in female embryos. We now report on ovarian cancer in the same cohort. Our hypothesis was that the risk of this cancer would also be higher in women whose mothers had broader hips. We found that, when compared with all other women, the hazard ratio for ovarian cancer was 3.3 (95% CI 1.6–7.0, P = 0.004) in the daughters of mothers whose interspinous diameter was greater than 27 cm. Among mothers who had an early menarche, each measure of broad hips was associated with increased risk of ovarian cancer in their daughters. We postulate that ovarian cancer is initiated by exposure of the fetal ovary to maternal sex hormones. Concentrations of these hormones may be higher in mothers who had an early menarche. The maternal sex hormone profile that initiates ovarian cancer may be the product of poor nutrition and growth in early childhood followed by catch-up pre-pubertal growth. PMID:18461601

  15. Growth hormone mediates pubertal skeletal development independent of hepatic IGF-1 production.

    Science.gov (United States)

    Courtland, Hayden-William; Sun, Hui; Beth-On, Mordechay; Wu, Yingjie; Elis, Sebastien; Rosen, Clifford J; Yakar, Shoshana

    2011-04-01

    Deficiencies in either growth hormone (GH) or insulin-like growth factor 1 (IGF-1) are associated with reductions in bone size during growth in humans and animal models. Liver-specific IGF-1-deficient (LID) mice, which have 75% reductions in serum IGF-1, were created previously to separate the effects of endocrine (serum) IGF-1 from autocrine/paracrine IGF-1. However, LID mice also have two- to threefold increases in GH, and this may contribute to the observed pubertal skeletal phenotype. To clarify the role of GH in skeletal development under conditions of significantly reduced serum IGF-1 levels (but normal tissue IGF-1 levels), we studied the skeletal response of male LID and control mice to GH inhibition by pegvisomant from 4 to 8 weeks of age. Treatment of LID mice with pegvisomant resulted in significant reductions in body weight, femur length (Le), and femur total area (Tt.Ar), as well as further reductions in serum IGF-1 levels by 8 weeks of age, compared with the mean values of vehicle-treated LID mice. Reductions in both Tt.Ar and Le were proportional after treatment with pegvisomant. On the other hand, the relative amount of cortical tissue formed (RCA) in LID mice treated with pegvisomant was significantly less than that in both vehicle-treated LID and control mice, indicating that antagonizing GH action, either directly (through GH receptor signaling inhibition) or indirectly (through further reductions in serum/tissue IGF-1 levels), results in disproportionate reductions in the amount of cortical bone formed. This resulted in bones with significantly reduced mechanical properties (femoral whole-bone stiffness and work to failure were markedly decreased), suggesting that compensatory increases of GH in states of IGF-1 deficiency (LID mice) act to protect against a severe inhibition of bone modeling during growth, which otherwise would result in bones that are too weak for normal and/or extreme loading conditions.

  16. Sexually transmitted diseases and sexual function.

    Science.gov (United States)

    Sadeghi-Nejad, Hossein; Wasserman, Marlene; Weidner, Wolfgang; Richardson, Daniel; Goldmeier, David

    2010-01-01

    There is a need for state-of-the-art information in the area of sexually transmitted infections (STIs) in relation to sexual function. There are an estimated 60 million people living with and 340 million with treatable STIs. Surveys show sexual problems to be as high as 35% for men and 55% for women; however, there is little research directly assessing relationships between infection and sexual function. To show that STIs are associated with (and may cause) sexual dysfunction. Conversely, sexual dysfunction can increase patients' risk of STI acquisition. In men, erectile dysfunction (ED) associated with condom use may lead to unsafe sexual practices and, hence, STI acquisition. The role of various therapies including phosphodiesterase type 5 inhibitors in the treatment of ED in positive men taking social drugs will be explored. To provide state-of-the-art knowledge concerning sexual function and STIs, representing the opinions of five experts from four countries developed in a consensus process and encompassing a detailed literature review over a 2-year period. Expert opinion was based on the grading of evidence-based medical literature, widespread internal committee discussion, public presentation, and debate. This article highlights major factors causing the spread of STIs and suggests management interventions to prevent further spread of HIV/STIs, focusing on the juxtaposition between STIs and sexual functioning. Women's unique vulnerabilities to HIV/STIs (biological and physiological issues, gender-based violence, gender inequity) and their impact on women's sexual function are reviewed. Similarly, men's unique vulnerabilities to HIV/STIs including condom use, disclosure, voluntary counseling and testing, multiple concurrent sexual partners, and recreational drug use--particularly in homosexual men--are explored, as is the association of prostatitis and sexual function. Lastly, the article reviews the relationship between circumcision and sexual dysfunction. A

  17. Sexual Distress and Sexual Problems During Pregnancy: Associations With Sexual and Relationship Satisfaction.

    Science.gov (United States)

    Vannier, Sarah A; Rosen, Natalie O

    2017-03-01

    Sexual problems are common during pregnancy, but the proportion of pregnant women who experience sexual distress is unknown. In non-pregnant samples, sexual distress is associated with lower sexual and relationship satisfaction. To identify the proportion of women experiencing sexual distress during pregnancy and to compare the sexual and relationship satisfaction of women who report sexual distress during pregnancy with that of women without distress. Two-hundred sixty-one pregnant women completed a cross-sectional online survey. Women completed validated measurements of sexual functioning (Female Sexual Function Index; score relationship satisfaction (Couples Satisfaction Index). Overall, 42% of women met the clinical cutoff for sexual distress. Of sexually active women (n = 230), 26% reported concurrent sexual problems and distress and 14% reported sexual distress in the absence of sexual problems. Sexual distress and/or problems in sexual functioning were linked to lower sexual and relationship satisfaction compared with pregnant women with lower sexual distress and fewer sexual problems. Sexual distress is common during pregnancy and associated with lower sexual and relationship satisfaction. Health care providers should ask pregnant women about feelings of sexual distress. Identifying pregnant women who experience sexual distress and referring them to appropriate resources could help minimize sexual and relationship problems during pregnancy. Vannier SA, Rosen NO. Sexual Distress and Sexual Problems During Pregnancy: Associations With Sexual and Relationship Satisfaction. J Sex Med 2017;14:387-395. Copyright © 2017 International Society for Sexual Medicine. Published by Elsevier Inc. All rights reserved.

  18. Male sexuality with advancing age.

    Science.gov (United States)

    Jung, Andreas; Schill, Wolf-Bernhard

    2004-04-15

    People aged 60 years or older are commonly given the image of grandparents who are sexually rather inactive. However, a high percentage of men over 60 years have sexual desires and are sexually active. Aging men need more time and more direct stimulation of the penis to achieve full erection. The risk of developing erectile dysfunction increases with age. Almost one man in 22 aged 60-69 years without previous erection problems develops erectile dysfunction within 1 year. Hormone replacement therapy is only indicated if testosterone deficiency is combined with the syndrome of the "aging male" and lack of other disorders that are possibly causative and could be treated. For hormone replacement therapy testosterone gel preparations are preferable because they have a short half-time and can be immediately discontinued in the event that a pre-existing occult prostate carcinoma is stimulated.

  19. Does soaking temperature during controlled slow freezing of pre-pubertal mouse testes influence course of in vitro spermatogenesis?

    Science.gov (United States)

    Arkoun, Brahim; Dumont, Ludovic; Milazzo, Jean-Pierre; Rondanino, Christine; Bironneau, Amandine; Wils, Julien; Rives, Nathalie

    2016-06-01

    The banking of testicular tissue before highly gonadotoxic treatment is a prerequisite for the preservation of fertility in pre-pubertal boys not yet producing sperm. The aim of the current study is to evaluate the impact of a soaking temperature performed at -7 °C, -8 °C or -9 °C on the ability of frozen-thawed mouse spermatogonial stem cells (SSCs) to generate haploid germ cells after in vitro maturation. Testes of 6.5-day-old post-partum CD-1 mice were cryopreserved by using a controlled slow freezing protocol with soaking at -7 °C, -8 °C or -9 °C. Frozen-thawed pre-pubertal testicular tissues were cultured in vitro on agarose gel for 30 days. Histological evaluations were performed and flagellated late spermatids were counted after mechanical dissection of the cultured tissues. The differentiation of frozen SSCs into elongated spermatids was more efficient after treatment at -9 °C than at -7 °C and -8 °C. After dissection, flagellated late spermatids were observed by using Shorr staining. The number of flagellated late spermatids was significantly decreased after slow freezing when compared with a fresh tissue control. Therefore, the soaking temperature during slow freezing of pre-pubertal mouse testicular tissue might positively influence the course of in vitro spermatogenesis. Our slow freezing protocol with a soaking temperature at -9 °C was the optimal condition in terms of the achievement of in vitro spermatogenesis with a higher production of elongated spermatids, although the effectiveness of the maturation process was reduced compared with the fresh tissue control.

  20. Association between self-concept and body weight, gender, and pubertal development among male and female adolescents.

    Science.gov (United States)

    O'Dea, J A; Abraham, S

    1999-01-01

    This study examined the effects and interactions of gender, pubertal status, and body weight on the self-concept of 462 young adolescent Australian students from two different schools. All students enrolled in Years 7 and 8 completed the Self-Perception Profile for Adolescents, which includes several self-concept subscales and ratings of the importance of each subscale. The self-concept subscales ranked as most important by male and female students were Close Friendship, Scholastic Competence, and Job Competence. Females rated their ability to form close friendships significantly higher and of greater importance than did males. Standard body weight was related to students' Physical Appearance subscale scores, with higher weight students having lower self-concept, and postmenarcheal females having the poorest opinion of their physical appearance. Higher body weight males had lower scores on Athletic Competence, Job Competence, and Behavioral Conduct than did other males. Overweight females and normal weight males considered athletic competence to be more important than did other students. Pubertal status was related to students' scores on Athletic Competence, with postpubertal males who were not overweight scoring highest, and on Physical Appearance, with postmenarcheal females having the lowest opinion of their appearance. The mean self-concept score was significantly related to students' standard body weight, and there was an interaction between gender and puberty, with postpubertal males having the highest and postmenarcheal females the lowest self-concept score. The discrepancy score suggested that females felt they had failed to meet their ideal self-concept significantly more than did males. The results suggest that school programs should be implemented to provide exercise and job skill training suitable for all students, especially those who are overweight. These programs, while taking into account students' pubertal status, should aim to improve self

  1. A comparison of the simplified olecranon and digital methods of assessment of skeletal maturity during the pubertal growth spurt.

    Science.gov (United States)

    Canavese, F; Charles, Y P; Dimeglio, A; Schuller, S; Rousset, M; Samba, A; Pereira, B; Steib, J-P

    2014-11-01

    Assessment of skeletal age is important in children's orthopaedics. We compared two simplified methods used in the assessment of skeletal age. Both methods have been described previously with one based on the appearance of the epiphysis at the olecranon and the other on the digital epiphyses. We also investigated the influence of assessor experience on applying these two methods. Our investigation was based on the anteroposterior left hand and lateral elbow radiographs of 44 boys (mean: 14.4; 12.4 to 16.1 ) and 78 girls (mean: 13.0; 11.1 to14.9) obtained during the pubertal growth spurt. A total of nine observers examined the radiographs with the observers assigned to three groups based on their experience (experienced, intermediate and novice). These raters were required to determined skeletal ages twice at six-week intervals. The correlation between the two methods was determined per assessment and per observer groups. Interclass correlation coefficients (ICC) evaluated the reproducibility of the two methods. The overall correlation between the two methods was r = 0.83 for boys and r = 0.84 for girls. The correlation was equal between first and second assessment, and between the observer groups (r ≥ 0.82). There was an equally strong ICC for the assessment effect (ICC ≤ 0.4%) and observer effect (ICC ≤ 3%) for each method. There was no significant (p assessing skeletal maturity. The olecranon method offers detailed information during the pubertal growth spurt, while the digital method is as accurate but less detailed, making it more useful after the pubertal growth spurt once the olecranon has ossified. ©2014 The British Editorial Society of Bone & Joint Surgery.

  2. AB32. Sexuality after kidney transplantation

    Science.gov (United States)

    Zhang, Xiaodong

    2014-01-01

    impotent. For women, 35% on HD and 23% with a KTx reported frequency of orgasm during sexual intercourse to be “unusual to never” at the time of treatment. Take home massages higher sexual disorder, less attention paid on this topic, more study needed as transplant volume expanded, diagnosis and treatment, sexuality associated QOL.

  3. Comparison of adolescents' reports of sexual behavior on a survey and sexual health history calendar.

    Science.gov (United States)

    Fisher, Colleen M; Lee, Michael G

    2014-01-01

    Assessing sexual risk is critical for human immunodeficiency virus (HIV) and sexually transmitted infection (STI) prevention with adolescents. This article compares sexual risk reports from two self-administered instruments, a standard survey and a sexual health history calendar (SHHC), among racially diverse youth (n = 232) ages 14 to 21 seeking services at a public health clinic. Agreement between methods was assessed using Lin's concordance correlation coefficients (CCC) and Bland-Altman plots. Lin's CCC showed poor to moderate agreement between instruments on reports of sexual partners in the past 3 (0.47), 6 (0.55), and 12 (0.49) months. While individual sexual partner questions were refused a total of 179 times on the survey, youth reported having sexual partners during the same time period on the SHHC in most (77.1%) of these instances. Poor agreement was also found for condom use frequency (CCC = 0.17), with youth's frequency of condom use on the SHHC differing from that reported on the survey for more than half (55.6%) of the months they were sexually active. While lack of objective sexual behavior measures limits conclusions about the accuracy of reports, the ways in which youth's responses varied across instruments may offer insight into the complexity of adolescent sexual risk taking as well as have important implications for development of HIV/STI preventive interventions.

  4. The Double Standard at Sexual Debut: Gender, Sexual Behavior and Adolescent Peer Acceptance.

    Science.gov (United States)

    Kreager, Derek A; Staff, Jeremy; Gauthier, Robin; Lefkowitz, Eva S; Feinberg, Mark E

    2016-10-01

    A sexual double standard in adolescence has important implications for sexual development and gender inequality. The present study uses longitudinal social network data (N = 914; 11-16 years of age) to test if gender moderates associations between adolescents' sexual behaviors and peer acceptance. Consistent with a traditional sexual double standard, female adolescents who reported having sex had significant decreases in peer acceptance over time, whereas male adolescents reporting the same behavior had significant increases in peer acceptance. This pattern was observed net of respondents' own perceived friendships, further suggesting that the social responses to sex vary by gender of the sexual actor. However, findings for "making out" showed a reverse double standard, such that female adolescents reporting this behavior had increases in peer acceptance and male adolescents reporting the same behavior had decreases in peer acceptance over time. Results thus suggest that peers enforce traditional sexual scripts for both "heavy" and "light" sexual behaviors during adolescence. These findings have important implications for sexual health education, encouraging educators to develop curricula that emphasize the gendered social construction of sexuality and to combat inequitable and stigmatizing peer responses to real or perceived deviations from traditional sexual scripts.

  5. Peer Sexual Health Education: Interventions for Effective Programme Evaluation

    Science.gov (United States)

    Sriranganathan, Gobika; Jaworsky, Denise; Larkin, June; Flicker, Sarah; Campbell, Lisa; Flynn, Susan; Janssen, Jesse; Erlich, Leah

    2012-01-01

    Peer education is used as a health promotion strategy in a number of areas, including sexual health. Although peer education programmes have been around for some time, published systematic evaluations of youth sexual health peer education programmes are rare. This article discusses the advantages and disadvantages of youth sexual health peer…

  6. Exploring Parental Perspectives on Parent-Child Sexual Communication

    Science.gov (United States)

    Ballard, Sharon M.; Gross, Kevin H.

    2009-01-01

    We examined parental perspectives about parent-child sexual communication through four focus groups conducted with 25 parents of young children. Participant comments fell into six areas: 1) personal experience with sexuality education, 2) current sexuality education efforts, 3) comfort and confidence, 4) content and timing, 5) importance of a…

  7. An Abstinence Program's Impact on Cognitive Mediators and Sexual Initiation

    Science.gov (United States)

    Weed, Stan E.; Ericksen, Irene H.; Lewis, Allen; Grant, Gale E.; Wibberly, Kathy H.

    2008-01-01

    Objectives: To evaluate the impact of an abstinence education program on sexual intercourse initiation and on possible cognitive mediators of sexual initiation for virgin seventh graders in suburban Virginia. Methods: Measures of sexual behavior and 6 mediating variables were compared at 3 time periods for program participants and a matched…

  8. Sexuality in eating disorders patients: etiological factors, sexual dysfunction and identity issues. A systematic review.

    Science.gov (United States)

    Castellini, Giovanni; Lelli, Lorenzo; Ricca, Valdo; Maggi, Mario

    2016-02-01

    The scientific community appears to be less interested in sexuality of eating disorders (EDs) as compared to other psychiatric or medical comorbidities. However, a clear association between sexual problems and ED psychopathology was reported from different perspectives. The overarching goal of this systematic review was to evaluate the general approach of the scientific literature toward the topic of sexuality and EDs. In particular, four different categories of research have been individuated, encompassing the role of puberty, and sexual abuse in the pathogenesis of the disorders, sexual dysfunctions, and the association between sexual orientation and EDs psychopathology. Timing of puberty with its hormonal consequences and the changes in the way persons perceive their own body represent a crucial period of life for the onset of the disorder. Sexual abuse, and especially childhood sexual abuse are well-recognized risk factors for the development of ED, determining a worse long-term outcome. Recent research overcome the approach that considers sexual activity of EDs patients, in terms of hypersexuality and dangerous sexual behaviors, considering the sexuality of EDs persons in terms of sexual desire, satisfaction, orgasm and pain. Results from this line of research are promising, and describe a clear relationship between sexual dysfunction and the core psychopathological features of EDs, such as body image disturbances. Finally, the analysis of the literature showed an association between sexual orientation and gender dysphoria with EDs psychopathology and pathological eating behaviors, confirming the validity of research developing new models of maintaining factors of EDs related to the topic of self-identity.

  9. Biology of Sexual Dysfunction

    Directory of Open Access Journals (Sweden)

    Anil Kumar Mysore Nagaraj

    2009-05-01

    Full Text Available Sexual activity is a multifaceted activity, involving complex interactions between the nervous system, the endocrine system, the vascular system and a variety of structures that are instrumental in sexual excitement, intercourse and satisfaction. Sexual function has three components i.e., desire, arousal and orgasm. Many sexual dysfunctions can be categorized according to the phase of sexual response that is affected. In actual clinical practice however, sexual desire, arousal and orgasmic difficulties more often than not coexist, suggesting an integration of phases. Sexual dysfunction can result from a wide variety of psychological and physiological causes including derangements in the levels of sex hormones and neurotrensmitters. This review deals with the biology of different phases of sexual function as well as implications of hormones and neurotransmitters in sexual dysfunction

  10. Characterization of Inappropriate Sexual Behaviour towards Children and Adolescents

    OpenAIRE

    Manuel Rodríguez González; Illovis Arteaga Ramírez; Osmel Rodríguez González

    2014-01-01

    Background: child sexual abuse is a reality that deeply lacerates families and individuals who suffer it.Objective: to characterize child victims of sexual abuse.Methods: a descriptive study was conducted in 2012 at the Dr. Gustavo Aldereguía Lima Hospital, involving 50 victims of sexual abuse less than 16 years of age who were assessed by the Forensic Psychiatric Evaluation Commission. Sex, age, origin, form and frequency of sexual abuse, relationship to perpetrator, place and time of occurr...

  11. Effects of Sexuality Information on Sexual Behavior and Control of ...

    African Journals Online (AJOL)

    Effects of Sexuality Information on Sexual Behavior and Control of Sexually ... the knowledge of sexuality among different categories of school teenagers and to ... of structured self-administered questionnaires haven obtained relevant consent.

  12. Sexual narcissism and the perpetration of sexual aggression.

    Science.gov (United States)

    Widman, Laura; McNulty, James K

    2010-08-01

    Despite indirect evidence linking narcissism to sexual aggression, studies directly examining this relationship have yielded inconsistent results. Likely contributing to such inconsistencies, prior research has used global measures of narcissism not sensitive to whether the components of narcissism are activated in sexual versus non-sexual domains. The current research avoided such problems by using a measure of sexual narcissism to predict sexual aggression. In a sample of 299 men and women, Study 1 validated the Sexual Narcissism Scale, a new sexuality research instrument with four subscales-Sexual Exploitation, Sexual Entitlement, Low Sexual Empathy, and Sexual Skill. Then, in a sample of 378 men, Study 2 demonstrated that sexual narcissism was associated with reports of the frequency of sexual aggression, three specific types of sexual aggression (unwanted sexual contact, sexual coercion, and attempted/completed rape), and the likelihood of future sexual aggression. Notably, global narcissism was unrelated to all indices of sexual aggression when sexual narcissism was controlled. That sexual narcissism outperformed global assessments of narcissism to account for variance in sexual aggression suggests that future research may benefit by examining whether sexual narcissism and other sexual-situation-specific measurements of personality can similarly provide a more valid test of the association between personality and other sexual behaviors and outcomes (e.g., contraceptive use, infidelity, sexual satisfaction).

  13. Adolescents' Use of Sexually Explicit Internet Material and Their Sexual Attitudes and Behavior: Parallel Development and Directional Effects

    Science.gov (United States)

    Doornwaard, Suzan M.; Bickham, David S.; Rich, Michael; ter Bogt, Tom F. M.; van den Eijnden, Regina J. J. M.

    2015-01-01

    Although research has repeatedly demonstrated that adolescents' use of sexually explicit Internet material (SEIM) is related to their endorsement of permissive sexual attitudes and their experience with sexual behavior, it is not clear how linkages between these constructs unfold over time. This study combined 2 types of longitudinal modeling,…

  14. Sexual partner types and related sexual health risk among out-of-school adolescents in rural south-west Uganda

    NARCIS (Netherlands)

    Nobelius, A.; Kalina, B.; Pool, R.; Whitworth, J.; Chesters, J.; Power, R.

    2011-01-01

    This paper focuses on ‘sexual debut’ among out-of-school youth in Masaka District, Uganda, factors influencing its timing and assistance young people feel they need to delay sexual initiation. Data were drawn from a sexual health needs assessment using applied anthropological techniques with young p

  15. Sexual dysfunction among youth: an overlooked sexual health concern

    OpenAIRE

    Moreau, Caroline; Kågesten, Anna E; Blum, Robert Wm

    2016-01-01

    Background There is growing recognition that youth sexual health entails a broad range of physical, emotional and psychosocial responses to sexual interactions, yet little is known about sexual dysfunctions and well being in youth populations. This study explored sexual dysfunctions among youth and its associations with other domains of sexual health. Sexual dysfunctions were defined as: problems related to orgasm, pain during intercourse, lack of sexual desire or sexual pleasure. Methods Dat...

  16. Inappropriate sexual behavior.

    Science.gov (United States)

    Philo, S W; Richie, M F; Kaas, M J

    1996-11-01

    Inappropriate sexual behavior, or sexually aggressive behavior, is a term which encompasses a variety of behaviors, including obscene gesturing, touching or hugging another person, exposing body parts or disrobing, and masturbating in public. Inappropriate sexual behavior often elicits feelings of anxiety, embarrassment, or unease in the caregiver and the result is often disruption in continuity of care for the patient. The cause of inappropriate sexual behavior varies among individuals and careful assessment of the etiology of the behavior is the first essential step in intervening. Nursing interventions focus upon providing opportunities for expression of appropriate sexual behavior while attempting to extinguish inappropriate sexual behavior.

  17. Female adolescent sexuality. Promoting healthy sexual development.

    Science.gov (United States)

    Blythe, M J; Rosenthal, S L

    2000-03-01

    Health care providers must recognize the specific challenges and rewards of providing services for adolescents. Quality care begins with the establishment of trust, respect, and confidentiality between the health care provider and the adolescent. Data suggest that the normal age for beginning puberty is decreasing, which has important clinical, educational, and social implications. The health care provider should be aware of the broad range of potential sexual behaviors involving adolescents, as well as the teen's acceptance of such behaviors, often dictated by age, gender, culture, and education. When providing gynecologic care to adolescent girls, the physician should not only provide contraception and screen for sexually transmitted diseases but should contribute to the development of the patient's sexual health. Especially when providing care for the younger teen, the health care provider must focus on involving a member of the family or another significant adult to provide needed support and guidance. Anticipatory guidance for parents should focus on assessing their parenting styles and promoting supervision. Although parents should strive to maintain open communication with their adolescents, they may not accurately estimate the sexual activity of and the sexual risk for their teenage children. Parents need to be encouraged to consider the implications of their own sexual behaviors. The provider should attempt to foster a comfortable environment in which youth may seek help and support for appropriate medical care while reserving the right to disclose their sexual identity when ready. Health care professionals cannot exclude heterosexual behavior on the basis that a young woman self-identifies as homosexual. Her reported sexual behaviors may not indicate her sexual orientation. Self-definition of sexual orientation is a dynamic process including factors such as fantasies, desires, and behaviors. Self-definition of sexual identity is affected by individual

  18. Can the UroLift prostatic implant device treat the symptoms of benign prostatic hypertrophy, avoid sexual dysfunction and reduce hospital TURP waiting times? A single centre, single surgeon experience and review of the literature.

    Science.gov (United States)

    Bardoli, Antonio D; Taylor, Will St J; Mahmalji, Wasim

    2017-09-01

    BPH associated with LUTS and sexual dysfunction is common. We performed UroLift on 11 patients, average age 71 years (range 56-90). IPSS improved by an average of 9 points post-procedure. Pre-operatively their post-void residuals were 306.3 ml (range 120-499 ml SD [120.6]) and their QMAX was 7 ml/s (range 4-14 SD [2.8] ml/s). Post-procedure the post-void residual decreased by 35.4% at 4 months (mean difference - 106.3 ml). QMAX improved by an average of 1.7 ml/s, which was not statistically significant. No patients suffered any sexual dysfunction side effects and all patients were satisfied with their result. Hospital stay and theatre time were significantly reduced. Average length of stay was just 10.6 (6-18) hours and average theatre time just 18.7 (12-30) min. This is significantly faster than other surgery for LUTS. We therefore feel that there are significant benefits for both the patients, who are able to go home much faster, and also the hospital, who are able to perform far more surgeries for their patients. Patients also do not require an inpatient bed so patients should not be cancelled on the day of theatre.

  19. A longitudinal, mixed methods study of sexual position identity, behavior, and fantasies among young sexual minority men.

    Science.gov (United States)

    Pachankis, John E; Buttenwieser, Indiana G; Bernstein, Laura B; Bayles, Damon O

    2013-10-01

    Recent evidence suggests that young sexual minority men's sexual position identities (e.g., "top," "bottom," "versatile") may be governed by dynamic influences. Yet, no study has prospectively examined whether, how, and why this aspect of sexual minority men's sexuality changes over time. Consequently, the present study investigated the extent to which young sexual minority men use sexual position identities consistently over time, typical patterns of position identity change, explanations given for this change, and the correspondence of changing sexual position identities with changing sexual behavior and fantasies. A total of 93 young sexual minority men indicated their sexual position identity, behavior, and fantasies at two assessment points separated by 2 years. Following the second assessment, a subset (n = 28) of participants who represented the various sexual position identity change patterns provided explanations for their change. More than half (n = 48) of participants changed their sexual position identity. Participants showed a significant move away from not using sexual position identities toward using them and a significant move toward using "mostly top." Changes in position identity were reflected, although imperfectly, in changes in sexual behavior and largely not reflected in fantasy changes. Participants offered 11 classes of explanations for their identity changes referencing personal development, practical reasons, changing relationships, and sociocultural influences. Previous investigations of sexual minority men's sexual position identities have not adequately attended to the possibility of the changing use of the sexual position categories "top," "bottom," and "versatile" across young adulthood. Results of the present study suggest the possibility of a more fluid, context-dependent use of these terms than previously documented.

  20. Valproic Acid Metabolism and its Consequences on Sexual Functions.

    Science.gov (United States)

    Verrotti, Alberto; Mencaroni, Elisabetta; Cofini, Marta; Castagnino, Miriam; Leo, Antonio; Russo, Emilio; Belcastro, Vincenzo

    2016-01-01

    Valproic acid (VPA) is a broad spectrum antiepileptic drug (AED) that is generally regarded as a first-choice agent for most forms of idiopathic and symptomatic generalised epilepsies. Available data suggest that menstrual disorders and certain endocrine manifestations of reproductive system disorders may be more common in women treated with VPA than in those treated with other AEDs. A PubMed search for MEDLINE was undertaken to look for studies using the terms "VPA metabolism", "VPA and sexual functions in men", "VPA and sexual functions in women" and "VPA metabolism and endocrine disorders" as key words. The period covered was approximately 20 years. In women, VPA medication is associated with hyperandrogenism, polycystic ovary/polycystic ovarian syndrome, menstrual disorders and ovulatory failure. Men on VPA therapy show abnormalities in androgens blood levels, sperm motility and erectile dysfunctions. VPA negatively affects the release of luteinizing hormone, follicle stimulating hormone and prolactin but also the drug interferes in peripheral endocrine hormones. Its broad inhibitory action on cytochrome and glucuronidation systems can lead to high serum concentration of testosterone, androstenedione and dehydroepiandrosterone sulfate. VPA-dependent obesity and hyperinsulinemia can further contribute to an increase in sexual dysfunctions. VPA interferes with the endocrine system at multiples levels causing several reproductive and sexual dysfunctions in women and men with epilepsy, especially when administered in pubertal age. Since VPA is a first line AED both in children and adult with epilepsy and long-term medication with this drug is sometimes necessary, it is very important for physicians to implement strict monitoring of patients taking VPA in order to identify these kinds of side effects at an early stage.

  1. Sexual selection: Another Darwinian process.

    Science.gov (United States)

    Gayon, Jean

    2010-02-01

    Why was sexual selection so important to Darwin? And why was it de-emphasized by almost all of Darwin's followers until the second half of the 20th century? These two questions shed light on the complexity of the scientific tradition named "Darwinism". Darwin's interest in sexual selection was almost as old as his discovery of the principle of natural selection. From the beginning, sexual selection was just another "natural means of selection", although different from standard "natural selection" in its mechanism. But it took Darwin 30 years to fully develop his theory, from the early notebooks to the 1871 book The Descent of Man, and Selection in Relation to Sex. Although there is a remarkable continuity in his basic ideas about sexual selection, he emphasized increasingly the idea that sexual selection could oppose the action of natural selection and be non adaptive. In time, he also gave more weight to mate choice (especially female choice), giving explicit arguments in favor of psychological notions such as "choice" and "aesthetic sense". But he also argued that there was no strict demarcation line between natural and sexual selection, a major difficulty of the theory from the beginning. Female choice was the main reason why Alfred Russel Wallace, the co-discoverer of the principle of natural selection, engaged in a major controversy with Darwin about sexual selection. Wallace was suspicious about sexual selection in general, trying to minimize it by all sorts of arguments. And he denied entirely the existence of female choice, because he thought that it was both unnecessary and an anthropomorphic notion. This had something to do with his spiritualist convictions, but also with his conception of natural selection as a sufficient principle for the evolutionary explanation of all biological phenomena (except for the origin of mind). This is why Wallace proposed to redefine Darwinism in a way that excluded Darwin's principle of sexual selection. The main result of

  2. Sexuality and psychosis.

    Science.gov (United States)

    Skodlar, Borut; Nagy, Marija Zunter

    2009-09-01

    Sexuality and sexual disorders of patients with psychoses are frequently neglected and under-investigated. The main purpose of the present study is to discuss the subjective experience of sexuality in patients with psychosis within the general psychodynamic and phenomenological understandings of psychotic states. The authors, both psychotherapists, dealing with patients with psychoses, reflected experiences from their clinical work with the help of the conceptual frameworks of psychodynamic and phenomenological psychiatry. Willingness and need of patients to talk about sexuality, non-specificity of frequencies and variety of sexual disorders in psychotic patients, difficulties in establishment of a stable (sexual) identity and the question of homosexuality, absence of sexual activities with others and feelings of guilt and inadequacy, masturbation with its functions, impulsive sexual acts or lack of sexual self-control, erotic delusions and erotic transference were the main findings, dominating the sexual sphere of these patients. All these manifestations of sexuality in patients with psychosis can be seen - as exposed in discussion - as consequences of a basic self-disorder (phenomenological perspective) or of difficulties in regulating closeness and distance (psychodynamic perspective). Reasons of avoidance of treatment of sexuality by the therapists of psychotic patients are discussed as well. Implications for dealing with sexuality issues in psychotherapy of patients with psychoses were drawn from the above findings in the last part of the article.

  3. A longitudinal examination of sexually transmitted infection/HIV prevention knowledge and sexually transmitted infections among African-American adolescent females.

    Science.gov (United States)

    Voisin, Dexter R; Tan, Kevin; DiClemente, Ralph J

    2013-12-01

    This study examines whether sexually transmitted infection prevention knowledge predicts the acquisition of biologically confirmed sexually transmitted infections among African-American adolescent females. A total of 715 females were recruited from public health clinics in Atlanta, Georgia, and using audio computer-assisted self-interview technology, we assessed for demographics, sexually transmitted infection prevention knowledge, risky sexual behaviors, and sexually transmitted infections. After controlling for demographics and prior risky sexual behaviors, participants with high prevention knowledge were 0.09 times less likely to report sexually transmitted infections, and those with multiple sexual partners were 1.3 times more likely to report sexually transmitted infections. Our findings suggest that the promotion of accurate sexually transmitted prevention knowledge is critical especially among females with multiple sex partners.

  4. Differences in Sexual Orientation Diversity and Sexual Fluidity in Attractions Among Gender Minority Adults in Massachusetts.

    Science.gov (United States)

    Katz-Wise, Sabra L; Reisner, Sari L; Hughto, Jaclyn White; Keo-Meier, Colton L

    2016-01-01

    This study characterized sexual orientation identities and sexual fluidity in attractions in a community-based sample of self-identified transgender and gender-nonconforming adults in Massachusetts. Participants were recruited in 2013 using bimodel methods (online and in person) to complete a one-time, Web-based quantitative survey that included questions about sexual orientation identity and sexual fluidity. Multivariable logistic regression models estimated adjusted risk ratios (aRRs) and 95% confidence intervals (95% CIs) to examine the correlates of self-reported changes in attractions ever in lifetime among the whole sample (n = 452) and after transition among those who reported social gender transition (n = 205). The sample endorsed diverse sexual orientation identities: 42.7% queer, 19.0% other nonbinary, 15.7% bisexual, 12.2% straight, and 10.4% gay/lesbian. Overall, 58.2% reported having experienced changes in sexual attractions in their lifetime. In adjusted models, trans masculine individuals were more likely than trans feminine individuals to report sexual fluidity in their lifetime (aRR = 1.69; 95% CI = 1.34, 2.12). Among those who transitioned, 64.6% reported a change in attractions posttransition, and trans masculine individuals were less likely than trans feminine individuals to report sexual fluidity (aRR = 0.44; 95% CI = 0.28, 0.69). Heterogeneity of sexual orientation identities and sexual fluidity in attractions are the norm rather than the exception among gender minority people.

  5. Scrutinizing Immutability: Research on Sexual Orientation and U.S. Legal Advocacy for Sexual Minorities.

    Science.gov (United States)

    Diamond, Lisa M; Rosky, Clifford J

    2016-01-01

    We review scientific research and legal authorities to argue that the immutability of sexual orientation should no longer be invoked as a foundation for the rights of individuals with same-sex attractions and relationships (i.e., sexual minorities). On the basis of scientific research as well as U.S. legal rulings regarding lesbian, gay, and bisexual (LGB) rights, we make three claims: First, arguments based on the immutability of sexual orientation are unscientific, given what we now know from longitudinal, population-based studies of naturally occurring changes in the same-sex attractions of some individuals over time. Second, arguments based on the immutability of sexual orientation are unnecessary, in light of U.S. legal decisions in which courts have used grounds other than immutability to protect the rights of sexual minorities. Third, arguments about the immutability of sexual orientation are unjust, because they imply that same-sex attractions are inferior to other-sex attractions, and because they privilege sexual minorities who experience their sexuality as fixed over those who experience their sexuality as fluid. We conclude that the legal rights of individuals with same-sex attractions and relationships should not be framed as if they depend on a certain pattern of scientific findings regarding sexual orientation.

  6. A Meta-Analysis of Disparities in Childhood Sexual Abuse, Parental Physical Abuse, and Peer Victimization Among Sexual Minority and Sexual Nonminority Individuals

    Science.gov (United States)

    Marshal, Michael P.; Guadamuz, Thomas E.; Wei, Chongyi; Wong, Carolyn F.; Saewyc, Elizabeth; Stall, Ron

    2011-01-01

    Objectives. We compared the likelihood of childhood sexual abuse (under age 18), parental physical abuse, and peer victimization based on sexual orientation. Methods. We conducted a meta-analysis of adolescent school-based studies that compared the likelihood of childhood abuse among sexual minorities vs sexual nonminorities. Results. Sexual minority individuals were on average 3.8, 1.2, 1.7, and 2.4 times more likely to experience sexual abuse, parental physical abuse, or assault at school or to miss school through fear, respectively. Moderation analysis showed that disparities between sexual minority and sexual nonminority individuals were larger for (1) males than females for sexual abuse, (2) females than males for assault at school, and (3) bisexual than gay and lesbian for both parental physical abuse and missing school through fear. Disparities did not change between the 1990s and the 2000s. Conclusions. The higher rates of abuse experienced by sexual minority youths may be one of the driving mechanisms underlying higher rates of mental health problems, substance use, risky sexual behavior, and HIV reported by sexual minority adults. PMID:21680921

  7. Sexual selection in marine plankton

    DEFF Research Database (Denmark)

    Sichlau, Mie Hylstofte

    . This is the first time that genetic polyandry has been documented in a pelagic copepod. Multiple paternity opens up for the possibility of post-copulatory sexual selection, such as sperm competition and cryptic female choice. We further found that mating was non-random, as we identified superior individuals...... behavioural studies and genetic parentage analyses to examine the fertilization status and occurrence of mate choice and polygamy in the copepod Temora longicornis (Copepoda, Calanoida). The overall objective of my PhD project was to examine the intensity and direction of sexual selection in T. longicornis...... and elucidate the role of sexual selection for the behaviour of individuals, the dynamics of populations, and the functioning of the pelagic ecosystem. I wanted to address the following overarching questions: i) What is the fraction of fertilized females in field and laboratory populations? Is it influenced...

  8. Sexuality education in Malaysia: perceived issues and barriers by professionals.

    Science.gov (United States)

    Khalaf, Zahra Fazli; Low, Wah Yun; Merghati-Khoei, Effat; Ghorbani, Behzad

    2014-07-01

    This research explored the perspectives of Malaysian professionals on the issues and barriers affecting the implementation of sexuality education in Malaysia. This qualitative study involved in-depth interviews with 15 key professionals working in the field of sexuality and reproductive health in Malaysia. Thematic analysis was selected to analyze data. Barriers to sexuality education were perceived from 5 aspects: feasibility, acceptability, accountability, strategies, and community unawareness. Respondents believed that implementing national sexuality education is a time-consuming project. They regarded Malaysian multicultural society as a barrier to national sexuality education, and they believed that school-based sexuality education is not easily accomplished in Malaysia; also abstinence-only policy restricts the access of young people to accurate information. Lack of community involvement was perceived as a key concern to sexuality education. Campaigning to promote awareness of families, teachers, community leaders, and policy makers are recommended to help establishing national sexuality education in Malaysia. © 2014 APJPH.

  9. Effect of Aegle marmelos and Murraya koenigii in treatment of delayed pubertal buffaloes heifers

    Directory of Open Access Journals (Sweden)

    Mohan M. Baitule

    2016-12-01

    . koenigii alone, were found effective in fertility improvement in delayed pubertal buffalo heifers by increasing ovulation and conception rate.

  10. Different effects on bone strength and cell differentiation in pre pubertal caloric restriction versus hypothalamic suppression.

    Science.gov (United States)

    Joshi, R N; Safadi, F F; Barbe, M F; Del Carpio-Cano, Fe; Popoff, S N; Yingling, V R

    2011-10-01

    Hypothalamic amenorrhea and energy restriction during puberty affect peak bone mass accrual. One hypothesis suggests energy restriction alters hypothalamic function resulting in suppressed estradiol levels leading to bone loss. However, both positive and negative results have been reported regarding energy restriction and bone strength. Therefore, the purpose of this study was to investigate energy restriction and hypothalamic suppression during pubertal onset on bone mechanical strength and the osteogenic capacity of bone marrow-derived cells in two models: female rats treated with gonadotropin releasing hormone antagonists (GnRH-a) or 30% energy restriction. At 23 days of age, female Sprague Dawley rats were assigned to three groups: control group (C, n=10), GnRH-a group (n=10), and Energy Restriction (ER, n=12) group. GnRH-a animals received daily injections for 27 days. The animals in the ER group received 70% of the control animals' intake. After sacrifice (50 days of age), body weight, uterine and muscle weights were measured. Bone marrow-derived stromal cells were cultured and assayed for proliferation and differentiation into osteoblasts. Outcome measures included bone strength, bone histomorphometry and architecture, serum IGF-1 and osteocalcin. GnRH-a suppressed uterine weight, decreased osteoblast proliferation, bone strength, trabecular bone volume and architecture compared to control. Elevated serum IGF-1 and osteocalcin levels and body weight were found. The ER model had an increase in osteoblast proliferation compared to the GnRH-a group, similar bone strength relative to body weight and increased trabecular bone volume in the lumbar spine compared to control. The ER animals were smaller but had developed bone strength sufficient for their size. In contrast, suppressed estradiol via hypothalamic suppression resulted in bone strength deficits and trabecular bone volume loss. In summary, our results support the hypothesis that during periods of

  11. Treatment of 28 Girl's Idiopathic Central Sexual Precocity

    Institute of Scientific and Technical Information of China (English)

    杨立础; 张宇; 黄建婷

    2001-01-01

    @@Twenty-eight girls suffering from idiopathic central sexual precocity were treated by integrated traditional Chinese and western medicine (TCM-WM), and compared with 16 girls treated with Leuprorelin acetate. METHODS Clinical Data According to the diagnostic standard proposed in "Pratical Pediatrics" (ZHU Fu-tang edit. 6th ed. People's Health Publishing House. 1996∶1915), 44 patients of true sexual precocity, who had pubertal development before they were 8 years old were selected. Cranial nuclear magnetic resonance (NMR) checking showed that the hypophysis of them were all normal on its sagittal plane and coronal plane. Hormone provocative test showed that the peak value of gonadal hormones in them, including follicule stimulating hormone (FSH), luteinizing hormone (LH), and estradiol (E2), were all above the normal range. And no disease of heart, liver, kidney, adrenal or thyroid was found. By Syndrome Differentiation of TCM, their Syndrome belonged to Yin-deficiency and Fire-hyperactivity type, chiefly manifesting as red tongue, irritation, thirsty and constipation.

  12. Scleroderma and Sexuality

    Science.gov (United States)

    Scleroderma and Sexuality INTRODUCTION If you or your partner have been diagnosed with scleroderma, you may be wondering how this will ... will continue to find satisfaction and enjoyment through sexuality. If you are single, you may wonder how ...

  13. Female sexuality in magazines

    Directory of Open Access Journals (Sweden)

    Luciana Patrícia Zucco

    2010-01-01

    Full Text Available This paper results from an investigation on the discourse of female sexuality carried by women's magazines in the years 2005 and 2006. 'Claudia' and 'Mulher dia-a-dia' were the documents analyzed through a qualitative investigative approach. The data construction was undertaken through critical discourse analysis, and female sexuality was approached from a constructivist perspective. The main results showed that the discursive conventions present in the reports gave shape to dual positions on contemporary Western sexual dynamics, such as: adoption of symmetrical sexual practices versus continuation of asymmetrical sexual practices; female sexual autonomy versus female sexual dependency; activeness versus passiveness; female pleasure versus male pleasure. Thus, we argue that sexuality remains doubly informed by hegemonic standards in force within society.

  14. Female Sexual Dysfunction

    Science.gov (United States)

    ... to be comfortable with your sexuality, improve your self-esteem and accept your body. Try practicing these healthy ... mayoclinic.org/diseases-conditions/female-sexual-dysfunction/basics/definition/CON-20027721 . Mayo Clinic Footer Legal Conditions and ...

  15. About Military Sexual Trauma

    Medline Plus

    Full Text Available ... total__ Find out why Close About Military Sexual Trauma Veterans Health Administration Loading... Unsubscribe from Veterans Health ... 10 VA HSR&D Investigator Insights: Military Sexual Trauma - Duration: 3:27. Veterans Health Administration 898 views ...

  16. Sexually Transmitted Diseases

    Science.gov (United States)

    Sexually transmitted diseases (STDs) are infections that are passed from one person to another through sexual contact. The causes of STDs ... often help with the symptoms and keep the disease under control. Correct usage of latex condoms greatly ...

  17. Sexual Problems in Men

    Science.gov (United States)

    Many men have sexual problems. They become more common as men age. Problems can include Erectile dysfunction Reduced or lost interest in sex ... problems may also be factors. Occasional problems with sexual function are common. If problems last more than ...

  18. Female Sexual Dysfunction

    Science.gov (United States)

    ... Endocrinologist Search Featured Resource Menopause Map™ View Female Sexual Dysfunction February 2012 Download PDFs English Espanol Editors ... Resources Mayo Clinic Cleveland Clinic What is female sexual dysfunction (FSD)? Many women have a low sex ...

  19. Number of sexual partners and sexual assertiveness predict sexual victimization: do more partners equal more risk?

    Science.gov (United States)

    Walker, Dave P; Messman-Moore, Terri L; Ward, Rose Marie

    2011-01-01

    In previous studies, number of sexual partners and sexual assertiveness were examined as independent risk factors for sexual victimization among college women. Using a sample of 335 college women, this study examined the interaction of number of sexual partners and sexual assertiveness on verbal sexual coercion and rape. Approximately 32% of the sample reported unwanted sexual intercourse, 6.9% (n = 23) experienced verbal sexual coercion, 17.9% (n = 60) experienced rape, and 7.2% (n = 24) experienced both. As number of sexual partners increased, instances of verbal sexual coercion increased for women low in relational sexual assertiveness but not for women high in relational sexual assertiveness. A similar relationship was not found for rape. Among women who experienced both verbal sexual coercion and rape, increases in number of partners in the context of low refusal and relational assertiveness were associated with increases in verbal sexual coercion and rape. Findings suggest sexual assertiveness is related to fewer experiences of sexual coercion.

  20. Dysfunctional anger and sexual violence.

    Science.gov (United States)

    Ahmed, A G

    2014-06-01

    Sexual offenses with or without aggression attract attention from the popular media and the scientific community. Empirical research suggests a relationship between anger and sexual violence. This article describes the key themes of dysfunctional anger and sexual violence, and how dysfunctional anger relates to sexual fantasies, sexual offending, and sexual recidivism. The implications of the findings for clinical practice and future research are discussed.