WorldWideScience

Sample records for pub lic health

  1. NOISE INDUCED HEARING LOSS IN CHINA:A POTENTIALLY COSTLY PUB-LIC HEALTH LSSUE

    Institute of Scientific and Technical Information of China (English)

    Shi Yongbing; William Hal Martin

    2013-01-01

    Hearing loss and tinnitus are among the most common consequences of long term noise exposure and re-main an under-addressed heath issue in most developing nations including China. The rapid industrializa-tion and life style changes in China increase the concern over noise exposure and noise induced hearing loss (NIHL). Research on NIHL in China is limited. The current paper reviews studies published in English and Chinese language literatures regarding noise exposure and NIHL in China. Their implication on the Chi-nese population is discussed. The possible utility of a research model such as the Dangerous Decibels® as a means to increase understanding of the scope of NIHL among the Chinese population, to educate the gener-al public in China (especially the young) about NIHL and its prevention, and to study effects of language and cultural factors on international information dissemination and behavioral interventions is proposed.

  2. Evidence for Informing Health Policy Development in Low- Income Countries (LICS: Perspectives of Policy Actors in Uganda

    Directory of Open Access Journals (Sweden)

    Juliet Nabyonga-Orem

    2015-05-01

    Full Text Available Background Although there is a general agreement on the benefits of evidence informed health policy development given resource constraints especially in Low-Income Countries (LICs, the definition of what evidence is, and what evidence is suitable to guide decision-making is still unclear. Our study is contributing to filling this knowledge gap. We aimed to explore health policy actors’ views regarding what evidence they deemed appropriate to guide health policy development. Methods Using exploratory qualitative methods, we conducted interviews with 51 key informants using an indepth interview guide. We interviewed a diverse group of stakeholders in health policy development and knowledge translation in the Uganda health sector. Data were analyzed using inductive content analysis techniques. Results Different stakeholders lay emphasis on different kinds of evidence. While donors preferred international evidence and Ministry of Health (MoH officials looked to local evidence, district health managers preferred local evidence, evidence from routine monitoring and evaluation, and reports from service providers. Service providers on the other hand preferred local evidence and routine monitoring and evaluation reports whilst researchers preferred systematic reviews and clinical trials. Stakeholders preferred evidence covering several aspects impacting on decision-making highlighting the fact that although policy actors look for factual information, they also require evidence on context and implementation feasibility of a policy decision. Conclusion What LICslike Uganda categorize as evidence suitable for informing policy encompasses several types with no consensus on what is deemed as most appropriate. Evidence must be of high quality, applicable, acceptable to the users, and informing different aspects of decision-making.

  3. PubChem

    Data.gov (United States)

    U.S. Department of Health & Human Services — PubChem contains the chemical structures of small organic molecules and information on their biological activities. PubChem includes substance information, compound...

  4. An Examination of Natural Language as a Query Formation Tool for Retrieving Information on E-Health from Pub Med.

    Science.gov (United States)

    Peterson, Gabriel M.; Su, Kuichun; Ries, James E.; Sievert, Mary Ellen C.

    2002-01-01

    Discussion of Internet use for information searches on health-related topics focuses on a study that examined complexity and variability of natural language in using search terms that express the concept of electronic health (e-health). Highlights include precision of retrieved information; shift in terminology; and queries using the Pub Med…

  5. Health informatics research in Australia: retrospective analysis using PubMed

    Directory of Open Access Journals (Sweden)

    Kumara Mendis

    2007-01-01

    Discussion Australian HI publications in PubMed increased consistently throughout the period 1970-2005, which is on a par with world trends in HI publications. In Australia, most HI publications are in general medical journals. Lack of consistency in author names and failure to include the country name and even the state are the main obstacles to PubMed bibliometric analysis.

  6. Military Review: SOF/LIC

    Science.gov (United States)

    1991-06-01

    capability. By modernizing the significantly demonstrated that when SEAL delivery vehicles and swimmer life sup- SOF and conventionalforces are port systems...has a d Imt pupose amd 1987 and January 1988 editions) states that the wquuw .d,,C cofre military role in LIC is indirect and supports the image ofi

  7. PubMed

    Data.gov (United States)

    U.S. Department of Health & Human Services — PubMed comprises more than 26 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to...

  8. Yebaoh .pub

    African Journals Online (AJOL)

    User

    and Tilden, 1983; Oakley, 1990; Williamson and Leferve, 1992). ... stress (Cohen and Wills,1985) . Stress here ... 1988). Social support, therefore, promotes good health, irrespective of the level of stress. Both ..... tween social support and health in S. Cohen and L.S Syme (eds). ... Durkheim, E. and Simpson, G. (eds). (1951).

  9. The 'LiC Detector Toy' program

    Science.gov (United States)

    Regler, M.; Mitaroff, W.; Valentan, M.; Frühwirth, R.; Höfler, R.

    2008-07-01

    LiC is a simple but powerful and flexible software tool, written in MatLab, for basic detector design studies (geometries, material budgets) by determining the resolution of reconstructed track parameters. It is based on a helix track model including multiple scattering, and consists of a simplified simulation of the detector followed by track reconstruction using the Kalman filter. After a short description of LiC's main characteristics, we demonstrate its capabilities by applying this tool in a performance study of the LDC and SiD detector concepts at the International Linear Collider (ILC).

  10. Advancing PubMed?

    DEFF Research Database (Denmark)

    Wildgaard, Lorna Elizabeth; Lund, Haakon

    2016-01-01

    the efficiency of biomedical literature searches. PubMed remains the primary resource for biomedical literature, and as PubMed makes the Medline data and Entrez PubMed Programming utilities freely available, any developer can produce alternative tools to search the database. The authors question if PubMed still...... provides the superior search interface for systematic searches or if the innovativeness of third-party tools provide alternatives worth considering. The paper aims to discuss these issues. Design/methodology/approach In all, 76 third-party tools that build on PubMed content were identified in a Pub...

  11. Advancing PubMed?

    DEFF Research Database (Denmark)

    Wildgaard, Lorna Elizabeth; Lund, Haakon

    2016-01-01

    Purpose Systematic reviews of biomedical literature are used to inform patient treatment. Yet the acquisition of relevant literature is proving increasingly challenging due to the large volume of information that needs to be searched, filtered and collocated. There is a need to improve...... provides the superior search interface for systematic searches or if the innovativeness of third-party tools provide alternatives worth considering. The paper aims to discuss these issues. Design/methodology/approach In all, 76 third-party tools that build on PubMed content were identified in a Pub...... the efficiency of biomedical literature searches. PubMed remains the primary resource for biomedical literature, and as PubMed makes the Medline data and Entrez PubMed Programming utilities freely available, any developer can produce alternative tools to search the database. The authors question if PubMed still...

  12. Formation of ultracold LiCs molecules

    CERN Document Server

    Kraft, S D; Lange, J; Vogel, L; Wester, R; Weidemüller, M; Kraft, Stephan D.; Staanum, Peter; Lange, Joerg; Vogel, Leif; Wester, Roland; Weidemueller, Matthias

    2006-01-01

    We present the first observation of ultracold LiCs molecules. The molecules are formed in a two-species magneto-optical trap and detected by two-photon ionization and time-of-flight mass spectrometry. The production rate coefficient is found to be in the range $10^{-18}\\unit{cm^3s^{-1}}$ to $10^{-16}\\unit{cm^3s^{-1}}$, at least an order of magnitude smaller than for other heteronuclear diatomic molecules directly formed in a magneto-optical trap.

  13. PubMed

    CERN Document Server

    PubMed is the National Library of Medicine's search service that provides access to over 10 million citations in MEDLINE, PreMEDLINE, and other related databases, with links to participating online journals.

  14. PubSCIENCE

    CERN Document Server

    United States. Department of Energy. Office of Scientific and Technical Information

    PubSCIENCE, a component of EnergyFiles, indexes 1,000 scientific and technical journals. It contains over one million multi-source journal citations dating back over 25 years from DOE's Energy Science and Technology Database. The focus of PubSCIENCE is on those journals where DOE researchers report their scientific discoveries. Frequency of contributions by DOE-sponsored researchers to scientific journals has been analyzed to prioritize data collection efforts. OSTI partners with participating publishers to provide information that is both relevant and useful to the DOE scientific community as well as information that was developed as the result of government sponsored R&D.

  15. Fiber Visualization with LIC Maps Using Multidirectional Anisotropic Glyph Samples

    Directory of Open Access Journals (Sweden)

    Mark Höller

    2014-01-01

    Full Text Available Line integral convolution (LIC is used as a texture-based technique in computer graphics for flow field visualization. In diffusion tensor imaging (DTI, LIC bridges the gap between local approaches, for example directionally encoded fractional anisotropy mapping and techniques analyzing global relationships between brain regions, such as streamline tracking. In this paper an advancement of a previously published multikernel LIC approach for high angular resolution diffusion imaging visualization is proposed: a novel sampling scheme is developed to generate anisotropic glyph samples that can be used as an input pattern to the LIC algorithm. Multicylindrical glyph samples, derived from fiber orientation distribution (FOD functions, are used, which provide a method for anisotropic packing along integrated fiber lines controlled by a uniform random algorithm. This allows two- and three-dimensional LIC maps to be generated, depicting fiber structures with excellent contrast, even in regions of crossing and branching fibers. Furthermore, a color-coding model for the fused visualization of slices from T1 datasets together with directionally encoded LIC maps is proposed. The methodology is evaluated by a simulation study with a synthetic dataset, representing crossing and bending fibers. In addition, results from in vivo studies with a healthy volunteer and a brain tumor patient are presented to demonstrate the method's practicality.

  16. PubChem Power User Gateway (PUG)

    Data.gov (United States)

    U.S. Department of Health & Human Services — PUG provides access to PubChem services via a programmatic interface. Users may download data, initiate chemical structure searches, standardize chemical structures...

  17. Dynamics of brassinosteroid response modulated by negative regulator LIC in rice.

    Directory of Open Access Journals (Sweden)

    Cui Zhang

    Full Text Available Brassinosteroids (BRs regulate rice plant architecture, including leaf bending, which affects grain yield. Although BR signaling has been investigated in Arabidopsis thaliana, the components negatively regulating this pathway are less well understood. Here, we demonstrate that Oryza sativa LEAF and TILLER ANGLE INCREASED CONTROLLER (LIC acts as an antagonistic transcription factor of BRASSINAZOLE-RESISTANT 1 (BZR1 to attenuate the BR signaling pathway. The gain-of-function mutant lic-1 and LIC-overexpressing lines showed erect leaves, similar to BZR1-depleted lines, which indicates the opposite roles of LIC and BZR1 in regulating leaf bending. Quantitative PCR revealed LIC transcription rapidly induced by BR treatment. Image analysis and immunoblotting showed that upon BR treatment LIC proteins translocate from the cytoplasm to the nucleus in a phosphorylation-dependent fashion. Phosphorylation assay in vitro revealed LIC phosphorylated by GSK3-like kinases. For negative feedback, LIC bound to the core element CTCGC in the BZR1 promoter on gel-shift and chromatin immunoprecipitation assay and repressed its transcription on transient transformation assay. LIC directly regulated target genes such as INCREASED LEAF INCLINATION 1 (ILI1 to oppose the action of BZR1. Repression of LIC in ILI1 transcription in protoplasts was partially rescued by BZR1. Phenotypic analysis of the crossed lines depleted in both LIC and BZR1 suggested that BZR1 functionally depends on LIC. Molecular and physiology assays revealed that LIC plays a dominant role at high BR levels, whereas BZR1 is dominant at low levels. Thus, LIC regulates rice leaf bending as an antagonistic transcription factor of BZR1. The phenotypes of lic-1 and LIC-overexpressing lines in erect leaves contribute to ideal plant architecture. Improving this phenotype may be a potential approach to molecular breeding for high yield in rice.

  18. Policy Challenges for Infrastructure Development in Asian LICs: Lessons from the Region

    OpenAIRE

    Fujita, Yasuo

    2012-01-01

    This paper discusses policy issues pertaining to infrastructure development in low income countries (LICs) in Asia. Infrastructure challenges in Asian LICs have not been adequately highlighted to date mainly because the international focus has often been on African LICs and because large countries such as China, India, and Indonesia attracted more interest among the developing Asian countries. While Asian LICs have sought to improve their infrastructure over the years, the quality and quantit...

  19. Integrating mental health in primary healthcare in low-income countries: changing the future for people with mental disorders.

    Science.gov (United States)

    Sørensen, Carina Winkler; Bæk, Ole; Kallestrup, Per; Carlsson, Jessica

    2017-02-01

    Untreated mental disorders are a huge challenge for healthcare systems worldwide. Treatment possibilities are particularly scarce in low-income countries (LICs). WHO estimates that up to 85% of all people with a mental disorder in LICs do not have access to evidence-based treatment. This paper seeks to explore the rationale behind the WHO recommendations for improving mental health services in LICs. At the core of these recommendations is an integration of mental health services into existing primary healthcare. This article presents available research supporting this approach. Furthermore, it highlights challenges needing special attention and opportunities demanding additional research to guide a comprehensive restructuring of a healthcare system. A literature review of WHO documents and searches on PubMed for relevant supporting literature. Research from LICs that investigate mental health interventions is scarce. The evidence that does exist favours integration into primary healthcare. There is evidence that collaborative- and stepped-care interventions can provide viable treatment options for patients. Integration of mental health services into primary healthcare seems like a viable solution to ensure that treatment becomes more available, even though the evidence is limited. Locally conducted research is needed to guide the development of sustainable evidence-based mental health treatment, involving relevant healthcare providers, with optimal task-sharing and possibilities for referral of complex cases. Furthermore, to achieve this, comprehensive political will and investments are necessary pre-requisites.

  20. kola 2.pub

    African Journals Online (AJOL)

    User

    POLLUTION IMPACT OF CEMENT PRODUCTION ON AIR,. SOIL AND WATER IN ... tion to using the rivers for irrigation. Keywords: Cement ..... tics Fresenius Environmental Bulletin 11: 1030–1033 .... World Health Organization (1999). Public.

  1. Worldwide access to evidence-based mental health literature: how useful is PubMed in Anglo-Saxon and non-Anglo-Saxon countries?

    Science.gov (United States)

    Morlino, Massimo; Polese, Daniela; Bruni, Andrea; Renato, Bellinello

    2005-10-01

    The aim of this study was to verify the presence of cultural variety among the psychiatric journals available on PubMed, the major online tool for accessing literature. Data for analysis were taken from a survey of the world psychiatric journals indexed in Index Medicus 1999 (IM), the alphabetical list used by PubMed, and from the mean impact factor (IF) values of the journals. Approximately 80% of international psychiatric literature available on PubMed is published in Anglo-Saxon countries, especially in the USA (59.8% of the total). The widespread use of the English language (94.9% of all the journals) further stresses the dominance of the Anglo-Saxon cultural model, as do the mean IF values of Anglo-Saxon journals compared to non-Anglo-Saxon publications (3.252 vs. 1.693; P=0.0079). The under-representation of non-Anglo-Saxon cultural models on PubMed plays a negative role for bringing about a truly multicultural literature in psychiatry.

  2. Franquicia GastroPub Torino

    OpenAIRE

    Schuler Falla, Philipp

    2014-01-01

    Es la construcción de un modelo de franquicia de restaurantes con la temática GastroPub que es una nueva tendencia originaria de europa. Es un restaurante que sirve comida colombiana gourmet, típica pero no común, en un ambiente de pub.

  3. 效率、公平与公共政策%Efficiency, Justice, and PubLic Policy

    Institute of Scientific and Technical Information of China (English)

    罗正业

    2011-01-01

    Efficiency and equity is a dialectic unity. Efficiency is assurance of economy, while equity is an important measure to weigh civilization and the basis of value foundation. So public policy must emphasize both of them. We keep a good assignment of resource through market and achieve fairness on the basis of socialism. The combination of efficiency and equity through which public policy is the manifestation of socialism is perfect.%效率是社会经济发展的重要保证,而公平是衡量人类文明的重要尺度,是维护社会稳定的价值基础。效率与公平是辩证的对立统一,既有矛盾性又有统一性。公共政策的关键就是要协调与整合二者之间的关系,确保既能提高经济效率,又能实现社会公平——借助市场机制达到资源的有效配置,以提高效率;依靠社会主义制度解决财富分配不公,以彰显公平。将效率与公平完美地结合于公共政策之中,是社会主义优越性的充分体现。

  4. Pub: Grid 2004, 2 signalement

    DEFF Research Database (Denmark)

    2004-01-01

    2. signalement er en af flere manifesteringer omkring det at skabe en tale omkring udfordringer. Pub: Grid 2004 indeholder en række arbejder, der afspejler et fagligt udviklingsarbejde på afdeling 6....

  5. The low-lying electronic states of LiC

    Science.gov (United States)

    Ricca, Alessandra; Bauschlicher, Charles W., Jr.; Langhoff, Stephen R. (Technical Monitor)

    1995-01-01

    The spectroscopic constants for the doublet and quartet states of LiC below about 30,000/cm are determined using an internally contracted multireference configuration-interaction approach in conjunction with a [6s 5p 3d 2f] atomic natural orbital basis sets. All of the strongly bound states, X(sup 4)(SIGMA)(sup -),(1)(sup 2)(DELTA), (1)(sup 2)(SIGMA)(sup +), and (2)(sup 2) II, very ionic in character. The only bound-bound quartet transition in this energy range is (2)(sup 4)SIGMA(sup -) and Franck-Condon factors, Einstein A values, and lifetimes are reported for this transition.

  6. Science in the (CERN) Pub!

    CERN Document Server

    2001-01-01

    The 6th Public Communication of Science and Technology network conference will end on Saturday 3 February with special performances. At 14:30 in the coffee area of restaurant no. 1 (Main Building) all participants and interested CERN members are invited to two events that will address science in an unorthodox and amusing way. Australian scientists will start with Science in the Pub, a fun discussion of topical science in an Australian pub ambiance (free Foster's beer served). Cabaret Pasteur, a French sample of entertainment with a scientific touch will follow.

  7. Laughing, grooming, and pub science.

    Science.gov (United States)

    Provine, Robert R

    2013-01-01

    On the basis of naturalistic observations of people conversing and laughing in pubs, a new study suggests that the 'grooming-at-a-distance' of laughter provides a three-fold increase in grooming group size, potentially explaining how hominins evolved social groups that are considerably larger than those of other primates.

  8. Structure and properties of Li@C60-PF6 endofullerene complex

    Science.gov (United States)

    Srivastava, Ambrish Kumar; Kumar, Abhishek; Misra, Neeraj

    2016-10-01

    Li@C60 is a prototype endofullerene, which has been widely studied. Employing density functional theory we study the interaction of Li@C60 with PF6 superhalogen, which leads to the formation of Li@C60-PF6 endofullerene complex. The spectral properties such as infrared and UV-visible spectra have been calculated, which agree well with corresponding experimental data. The vibrational assignments and electronic transitions in the complex have been explored. We have noticed that this complex is stabilized by charge transfer from Li@C60 to PF6, which results in its large dipole moment (20 Debye), high mean polarizability (494 a.u.) and significant mean hyperpolarizability (1500 a.u.). We, therefore, believe that Li@C60-PF6 endofullerene complex might attract further attention for their possible electrooptical applications due to its enhanced nonlinear optical properties.

  9. Determinants of health-related quality of life in patients with small cell lung cancer: a systematic PubMed review and meta-analysis

    Directory of Open Access Journals (Sweden)

    Aristomenis Kossioris

    2016-03-01

    Conclusions ― Health professionals could pay more attention to the management of cancer-related fatigue and dyspnea as well as to the enhancement of patients’ mobility through low-impact exercise programs or appropriate assistive devices.

  10. 76 FR 7862 - Implementation of the James Zadroga 9/11 Health and Compensation Act of 2010 (Pub. L. 111-347)

    Science.gov (United States)

    2011-02-11

    ... Act of 2010 established a program known as the World Trade Center (WTC) Health Program within HHS. The program shall be administered by the WTC Program Administrator; the Act includes: (1) Medical Monitoring... and analysis for enrolled WTC responders who were likely to have been exposed to airborne toxins that...

  11. The recombinant LIC10508 is a plasma fibronectin, plasminogen, fibrinogen and C4BP-binding protein of Leptospira interrogans.

    Science.gov (United States)

    Siqueira, Gabriela H; Teixeira, Aline F; Fernandes, Luis G; de Souza, Gisele O; Kirchgatter, Karin; Romero, Eliete C; Vasconcellos, Silvio A; Vieira, Monica L; Nascimento, Ana Lucia T O

    2016-03-01

    Leptospirosis is a zoonosis caused by pathogenic Leptospira spp. In this study, we report that the recombinant proteins LIC10507, LIC10508 and LIC10509 are recognized by confirmed leptospirosis serum samples at both phases of the disease. The recombinant rLIC10508 and rLIC10507 are plasminogen (PLG)-binding proteins, capable of generating plasmin in the presence of a PLG activator. The proteins bind to PLG in a dose-dependent and saturable manner, fulfilling host-ligand interaction. Furthermore, rLIC10508 interacts with fibrinogen (Fg), plasma fibronectin and C4b binding protein (C4BP). The binding of rLIC10508 to Fg decreases the fibrin clotting in a thrombin-catalyzed reaction. The incubation with 4 μM of protein promoted 40% inhibition upon clotting formation. C4BP bound to rLIC10508 retained its cofactor activity for factor I promoting the cleavage of C4b protein, which may reduce the membrane attack complex formation. Although these proteins have high amino acid sequence similarity, rLIC10508 is the most talented of the three, a behavior that might be explained by its unique putative 3D structure, whereas structures of rLIC10507 and rLIC10509 are very similar. Plasmin generation (rLIC10507 and rLIC10508), together with decreasing fibrin clot formation (rLIC10508) and impairment of the complement system (rLIC10508) may help the bacteria to overcome host defense, facilitating the infection process.

  12. Reactions of metallic Li or LiC6 with organic solvents for lithium ion battery

    Science.gov (United States)

    Nakajima, Tsuyoshi; Hirobayashi, Yuki; Takayanagi, Yuki; Ohzawa, Yoshimi

    2013-12-01

    DSC (Differential Scanning Calorimetry) study has been made on the reactions of metallic Li or LiC6 with organic solvents for lithium ion battery. Ethylene carbonate (EC) more easily reacts with metallic Li and LiC6 than propylene carbonate (PC). This may be because formation of lithium alkyl carbonate is more difficult for PC than EC. On the other hand, diethyl carbonate (DEC), ethyl methyl carbonate (EMC) and dimethyl carbonate (DMC) react with Li in the same manner. Reactions of Li and LiC6 with organic solvents have been discussed based on the results of quantum calculation.

  13. MedlinePlus FAQ: MedlinePlus and MEDLINE/PubMed

    Science.gov (United States)

    ... What is the difference between MedlinePlus and MEDLINE/PubMed? To use the sharing features on this page, ... latest health professional articles on your topic. MEDLINE/PubMed: Is a database of professional biomedical literature Is ...

  14. Pub Culture in the U.K.

    Institute of Scientific and Technical Information of China (English)

    孙鑫

    2015-01-01

    In the U.K., pubs can be seen everywhere. They play an important role in the British society. How pubs came into being in the U.K.? Why is pub culture formed and what makes it prosperous? What effects does pub culture make on British society both in the past and in the present? Does any British character be shown in pub culture in the U.K.? In this paper, I will give a brief in-troduction of pub culture's history and development in the U.K.. Besides, the above questions will be explored and analyzed one by one.

  15. PubChem atom environments.

    Science.gov (United States)

    Hähnke, Volker D; Bolton, Evan E; Bryant, Stephen H

    2015-01-01

    Atom environments and fragments find wide-spread use in chemical information and cheminformatics. They are the basis of prediction models, an integral part in similarity searching, and employed in structure search techniques. Most of these methods were developed and evaluated on the relatively small sets of chemical structures available at the time. An analysis of fragment distributions representative of most known chemical structures was published in the 1970s using the Chemical Abstracts Service data system. More recently, advances in automated synthesis of chemicals allow millions of chemicals to be synthesized by a single organization. In addition, open chemical databases are readily available containing tens of millions of chemical structures from a multitude of data sources, including chemical vendors, patents, and the scientific literature, making it possible for scientists to readily access most known chemical structures. With this availability of information, one can now address interesting questions, such as: what chemical fragments are known today? How do these fragments compare to earlier studies? How unique are chemical fragments found in chemical structures? For our analysis, after hydrogen suppression, atoms were characterized by atomic number, formal charge, implicit hydrogen count, explicit degree (number of neighbors), valence (bond order sum), and aromaticity. Bonds were differentiated as single, double, triple or aromatic bonds. Atom environments were created in a circular manner focused on a central atom with radii from 0 (atom types) up to 3 (representative of ECFP_6 fragments). In total, combining atom types and atom environments that include up to three spheres of nearest neighbors, our investigation identified 28,462,319 unique fragments in the 46 million structures found in the PubChem Compound database as of January 2013. We could identify several factors inflating the number of environments involving transition metals, with many

  16. Proteína LIC10494 de Leptospira interrogans serovar Copenhageni: modelo estructural y regiones funcionales asociadas

    OpenAIRE

    Orlando Emilio Acevedo; George Emílio Barreto; Janneth González-Santos

    2012-01-01

    Protein LIC10494 of Leptospira interrogans serovar Copenhageni: structural model and associated functional regions. Objective.Predict by computational means the 3D structure of the antigenic protein LIC10494 and report associated important functional regionsfor its pathogenicity and immunogenicity. Materials and methods. We performed a computational analysis of the primary structure ofLIC10494 using the servers BLAST, PROTPARAM, PROTSCALE, DAS, SOSUI, TOPPRED, TMAP, TMpred, SPLIT4, PHDHTM,TMH...

  17. 38 CFR 3.953 - Pub. L. 85-56 and Pub. L. 85-857.

    Science.gov (United States)

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2010-07-01 2010-07-01 false Pub. L. 85-56 and Pub. L... ADJUDICATION Pension, Compensation, and Dependency and Indemnity Compensation Protection § 3.953 Pub. L. 85-56 and Pub. L. 85-857. (a) In receipt of or entitled to receive benefits on December 31, 1958. Any person...

  18. Govt. Pubs.: NTIS Reference Sources.

    Science.gov (United States)

    Korman, Richard; Aluri, Rao

    1980-01-01

    Cites review sources for NTIS (National Technical Information Service) publications and provides an annotated list of 22 reports on child abuse, Chinese language romanization, criminal justice, energy, environment, ethnic data, fire technology, genealogy, health care, local communities and federal assistance, mainstreaming, political leadership in…

  19. PubMed Central Canada: Beyond an Open Access Repository?

    Science.gov (United States)

    Nariani, Rajiv

    2013-01-01

    PubMed Central Canada (PMC Canada) represents a partnership between the Canadian Institutes of Health Research (CIHR), the National Research Council's Canada Institute for Scientific and Technical Information (NRC-CISTI), and the National Library of Medicine of the US. The present study was done to gauge faculty awareness about the CIHR Policy on…

  20. PubMed Central Canada: Beyond an Open Access Repository?

    Science.gov (United States)

    Nariani, Rajiv

    2013-01-01

    PubMed Central Canada (PMC Canada) represents a partnership between the Canadian Institutes of Health Research (CIHR), the National Research Council's Canada Institute for Scientific and Technical Information (NRC-CISTI), and the National Library of Medicine of the US. The present study was done to gauge faculty awareness about the CIHR Policy on…

  1. Searching PubMed during a pandemic.

    Directory of Open Access Journals (Sweden)

    Ole Norgaard

    Full Text Available BACKGROUND: The 2009 influenza A(H1N1 pandemic has generated thousands of articles and news items. However, finding relevant scientific articles in such rapidly developing health crises is a major challenge which, in turn, can affect decision-makers' ability to utilise up-to-date findings and ultimately shape public health interventions. This study set out to show the impact that the inconsistent naming of the pandemic can have on retrieving relevant scientific articles in PubMed/MEDLINE. METHODOLOGY: We first formulated a PubMed search algorithm covering different names of the influenza pandemic and simulated the results that it would have retrieved from weekly searches for relevant new records during the first 10 weeks of the pandemic. To assess the impact of failing to include every term in this search, we then conducted the same searches but omitted in turn "h1n1," "swine," "influenza" and "flu" from the search string, and compared the results to those for the full string. PRINCIPAL FINDINGS: On average, our core search string identified 44.3 potentially relevant new records at the end of each week. Of these, we determined that an average of 27.8 records were relevant. When we excluded one term from the string, the percentage of records missed out of the total number of relevant records averaged 18.7% for omitting "h1n1," 13.6% for "swine," 17.5% for "influenza," and 20.6% for "flu." CONCLUSIONS: Due to inconsistent naming, while searching for scientific material about rapidly evolving situations such as the influenza A(H1N1 pandemic, there is a risk that one will miss relevant articles. To address this problem, the international scientific community should agree on nomenclature and the specific name to be used earlier, and the National Library of Medicine in the US could index potentially relevant materials faster and allow publishers to add alert tags to such materials.

  2. Universality of weakly bound dimers and Efimov trimers close to Li-Cs Feshbach resonances

    Science.gov (United States)

    Ulmanis, J.; Häfner, S.; Pires, R.; Kuhnle, E. D.; Weidemüller, M.; Tiemann, E.

    2015-05-01

    We study the interspecies scattering properties of ultracold Li-Cs mixtures in their two energetically lowest spin channels in the magnetic field range between 800 and 1000 G. Close to two broad Feshbach resonances (FR) we create weakly bound LiCs dimers by radio-frequency association and measure the dependence of their binding energy on the external magnetic field strength. Based on the binding energies and complementary atom loss spectroscopy of three other Li-Cs s-wave FRs we construct precise molecular singlet and triplet electronic ground state potentials using a coupled-channels calculation. We extract the Li-Cs interspecies scattering length as a function of the external field and obtain almost a ten-fold improvement in the precision of the values for the pole positions and widths of the s-wave FRs as compared to our previous work (Pires et al 2014 Phys. Rev. Lett. 112 250404). We discuss implications on the Efimov scenario and the universal geometric scaling for LiCsCs trimers.

  3. Ab initio calculation of the voltage profile for LiC6

    CSIR Research Space (South Africa)

    Kganyago, KR

    2003-03-01

    Full Text Available Energetics of the anode system LiC6 compared to metallic lithium is calculated within the framework of local-density functional theory (LDA-DFT) techniques. Our results suggest that the energy of anode intercalation results in a small change...

  4. Exploiting PubChem for Virtual Screening

    Science.gov (United States)

    Xie, Xiang-Qun

    2011-01-01

    Importance of the field PubChem is a public molecular information repository, a scientific showcase of the NIH Roadmap Initiative. The PubChem database holds over 27 million records of unique chemical structures of compounds (CID) derived from nearly 70 million substance depositions (SID), and contains more than 449,000 bioassay records with over thousands of in vitro biochemical and cell-based screening bioassays established, with targeting more than 7000 proteins and genes linking to over 1.8 million of substances. Areas covered in this review This review builds on recent PubChem-related computational chemistry research reported by other authors while providing readers with an overview of the PubChem database, focusing on its increasing role in cheminformatics, virtual screening and toxicity prediction modeling. What the reader will gain These publicly available datasets in PubChem provide great opportunities for scientists to perform cheminformatics and virtual screening research for computer-aided drug design. However, the high volume and complexity of the datasets, in particular the bioassay-associated false positives/negatives and highly imbalanced datasets in PubChem, also creates major challenges. Several approaches regarding the modeling of PubChem datasets and development of virtual screening models for bioactivity and toxicity predictions are also reviewed. Take home message Novel data-mining cheminformatics tools and virtual screening algorithms are being developed and used to retrieve, annotate and analyze the large-scale and highly complex PubChem biological screening data for drug design. PMID:21691435

  5. PubMedAlertMe--standalone Windows-based PubMed SDI software application.

    Science.gov (United States)

    Ma'ayan, Avi

    2008-05-01

    PubMedAlertMe is a Windows-based software system for automatically receiving e-mail alert messages about recent publications listed on PubMed. The e-mail messages contain links to newly available abstracts listed on PubMed describing publications that were selectively returned from a specified list of queries. Links are also provided to directly export citations to EndNote, and links are provided to directly forward articles to colleagues. The program is standalone. Thus, it does not require a remote mail server or user registration. PubMedAlertMe is free software, and can be downloaded from: http://amp.pharm.mssm.edu/PubMedAlertMe/PubMedAlertMe_setup.zip.

  6. PubMedAlertMe - Standalone Windows-based PubMed SDI Software Application

    Science.gov (United States)

    Ma’ayan, Avi

    2008-01-01

    PubMedAlertMe is a Windows-based software system for automatically receiving e-mail alert messages about recent publications listed on PubMed. The e-mail messages contain links to newly available abstracts listed on PubMed describing publications that were selectively returned from a specified list of queries. Links are also provided to directly export citations to EndNote, and links are provided to directly forward articles to colleagues. The program is standalone. Thus, it does not require a remote mail server or user registration. PubMedAlertMe is free software, and can be downloaded from: http://amp.pharm.mssm.edu/PubMedAlertMe/PubMedAlertMe_setup.zip PMID:18402930

  7. Predicting clicks of PubMed articles.

    Science.gov (United States)

    Mao, Yuqing; Lu, Zhiyong

    2013-01-01

    Predicting the popularity or access usage of an article has the potential to improve the quality of PubMed searches. We can model the click trend of each article as its access changes over time by mining the PubMed query logs, which contain the previous access history for all articles. In this article, we examine the access patterns produced by PubMed users in two years (July 2009 to July 2011). We explore the time series of accesses for each article in the query logs, model the trends with regression approaches, and subsequently use the models for prediction. We show that the click trends of PubMed articles are best fitted with a log-normal regression model. This model allows the number of accesses an article receives and the time since it first becomes available in PubMed to be related via quadratic and logistic functions, with the model parameters to be estimated via maximum likelihood. Our experiments predicting the number of accesses for an article based on its past usage demonstrate that the mean absolute error and mean absolute percentage error of our model are 4.0% and 8.1% lower than the power-law regression model, respectively. The log-normal distribution is also shown to perform significantly better than a previous prediction method based on a human memory theory in cognitive science. This work warrants further investigation on the utility of such a log-normal regression approach towards improving information access in PubMed.

  8. Polarons in endohedral Li+@C60- dimers and in 1D and 2D crystals

    Science.gov (United States)

    Kawazoe, Yoshiyuki; Belosludov, Vladimir R.; Zhdanov, Ravil K.; Belosludov, Rodion V.

    2017-10-01

    The electron charge distribution and polaron formation on the carbon sites of dimer clusters Li+@C60- and of 1D or 2D Li+@C60- periodic systems are studied with the use of the generalized Su-Schrieffer-Heeger model with respect to the intermolecular and intramolecular degrees of freedom. The charge distributions over the molecular surface and Jahn-Teller bond distortions of carbon atoms are calculated using the self-consistent iterative methods. Polarons formed in periodic 1D and 2D systems (chains and planar layers) as well as in dimer cluster system are examined. In the periodic systems polaron formation may be described by the cooperative Jahn-Teller effect. Orientation of the polarons on the molecule surface depends on the doping of the system, moreover, electron doping changes the energy levels in the system.

  9. A Screen Space GPGPU Surface LIC Algorithm for Distributed Memory Data Parallel Sort Last Rendering Infrastructures

    Energy Technology Data Exchange (ETDEWEB)

    Loring, Burlen; Karimabadi, Homa; Rortershteyn, Vadim

    2014-07-01

    The surface line integral convolution(LIC) visualization technique produces dense visualization of vector fields on arbitrary surfaces. We present a screen space surface LIC algorithm for use in distributed memory data parallel sort last rendering infrastructures. The motivations for our work are to support analysis of datasets that are too large to fit in the main memory of a single computer and compatibility with prevalent parallel scientific visualization tools such as ParaView and VisIt. By working in screen space using OpenGL we can leverage the computational power of GPUs when they are available and run without them when they are not. We address efficiency and performance issues that arise from the transformation of data from physical to screen space by selecting an alternate screen space domain decomposition. We analyze the algorithm's scaling behavior with and without GPUs on two high performance computing systems using data from turbulent plasma simulations.

  10. Mouse xenograft modeling of human adult acute lymphoblastic leukemia provides mechanistic insights into adult LIC biology

    Science.gov (United States)

    Dey, Aditi; Castleton, Anna Z.; Schwab, Claire; Samuel, Edward; Sivakumaran, Janani; Beaton, Brendan; Zareian, Nahid; Zhang, Christie Yu; Rai, Lena; Enver, Tariq; Moorman, Anthony V.; Fielding, Adele K.

    2014-01-01

    The distinct nature of acute lymphoblastic leukemia (ALL) in adults, evidenced by inferior treatment outcome and different genetic landscape, mandates specific studies of disease-initiating mechanisms. In this study, we used NOD/LtSz-scid IL2Rγ nullc (NSG) mouse xenotransplantation approaches to elucidate leukemia-initiating cell (LIC) biology in primary adult precursor B (pre-B) ALL to optimize disease modeling. In contrast with xenografting studies of pediatric ALL, we found that modification of the NSG host environment using preconditioning total body irradiation (TBI) was indispensable for efficient engraftment of adult non-t(4;11) pre-B ALL, whereas t(4;11) pre-B ALL was successfully reconstituted without this adaptation. Furthermore, TBI-based xenotransplantation of non-t(4;11) pre-B ALL enabled detection of a high frequency of LICs (<1:6900) and permitted frank leukemic engraftment from a remission sample containing drug-resistant minimal residual disease. Investigation of TBI-sensitive stromal-derived factor-1/chemokine receptor type 4 signaling revealed greater functional dependence of non-t(4;11) pre-B ALL on this niche-based interaction, providing a possible basis for the differential engraftment behavior. Thus, our studies establish the optimal conditions for experimental modeling of human adult pre-B ALL and demonstrate the critical protumorogenic role of microenvironment-derived SDF-1 in regulating adult pre-B LIC activity that may present a therapeutic opportunity. PMID:24825861

  11. Haemophilus influenzae LicB contributes to lung damage in an aged mice co-infection model.

    Science.gov (United States)

    Bondy, Jessica; Osharovich, Sofya; Storm, Julie; Durning, Graham; McAuliffe, Timothy; Fan, Xin

    2016-01-01

    Phosphorylcholine (ChoP) decoration of lipopolysaccharides is an important virulence strategy adopted by Haemophilus influenzae to establish a niche on the mucosal surface and to promote adherence to the host cells. The incorporation of ChoP on the LPS surface involves the lic1 operon, which consists of the licA, licB, licC, and licD genes. Among which, licB is a choline transporter gene required for acquisition of choline from environmental sources. In this study, we investigated the pathogenesis of the licB gene in an aged mice infection model. Due to immediate clearance of H. influenzae upon infection in mice, we employed influenza A virus and H. influenzae co-infection model. Our data showed that in the co-infection model, the secondary bacterial infection with a very low H. influenzae concentration of 100 colony forming unit is lethal to the aged mice. Although we did not observe any differences in weight loss between parent and licB mutant strains during the course of infection, a significant reduction of lung tissue damage was observed in the licB mutant infected aged mice. These results suggest that the licB gene is a virulence factor during H. influenzae infection in the lung in aged mice, possibly due to the increased binding to the host cell receptor via ChoP expression on the bacterial surface. In addition, when aged mice and mature mice were compared in the challenge experiments, we did not observe any protective immunity in the co-infection model suggesting the detrimental effects of the secondary bacterial infection on the aged mice in contrast to obvious immune-protections observed in the mature mice. The results of our experiments also implied that the co-infection model with influenza A virus and H. influenzae may be employed as a model system to study H. influenzae pathogenesis in vivo in aged mice.

  12. PubChemSR: A search and retrieval tool for PubChem

    Directory of Open Access Journals (Sweden)

    Wild David J

    2008-05-01

    Full Text Available Abstract Background Recent years have seen an explosion in the amount of publicly available chemical and related biological information. A significant step has been the emergence of PubChem, which contains property information for millions of chemical structures, and acts as a repository of compounds and bioassay screening data for the NIH Roadmap. There is a strong need for tools designed for scientists that permit easy download and use of these data. We present one such tool, PubChemSR. Implementation PubChemSR (Search and Retrieve is a freely available desktop application written for Windows using Microsoft .NET that is designed to assist scientists in search, retrieval and organization of chemical and biological data from the PubChem database. It employs SOAP web services made available by NCBI for extraction of information from PubChem. Results and Discussion The program supports a wide range of searching techniques, including queries based on assay or compound keywords and chemical substructures. Results can be examined individually or downloaded and exported in batch for use in other programs such as Microsoft Excel. We believe that PubChemSR makes it straightforward for researchers to utilize the chemical, biological and screening data available in PubChem. We present several examples of how it can be used.

  13. Literature Mapping with PubAtlas - extending PubMed with a 'BLASTing interface'.

    Science.gov (United States)

    Parker, D S; Chu, W W; Sabb, F W; Toga, A W; Bilder, R M

    2009-03-01

    PubAtlas (www.pubatlas.org) is a web service and standalone program providing literature maps for the biomedical research literature. It accepts user-defined sets of terms (PubMed queries) as input, and permits 'BLASTing' of one set against another: for all terms x and y in these sets, deriving the results of the pairwise intersections x AND y. This all vs. all capability extends PubMed with a literature analysis interface. Correspondingly, the basic form of literature map that PubAtlas provides for exploring associations among sets of terms is an interactive tabular display, in heatmap/microarray format.PubAtlas supports development of specialized lexica -- hierarchies of controlled terminology that can represent sets of related concepts or a 'user-defined query language'. PubAtlas also provides historical perspectives on the literature, with temporal query features that highlight historical patterns. Generally, it is a framework for extending the PubMed interface, and an extensible platform for producing interactive literature maps.

  14. PubChem3D: Similar conformers

    Directory of Open Access Journals (Sweden)

    Bolton Evan E

    2011-05-01

    Full Text Available Abstract Background PubChem is a free and open public resource for the biological activities of small molecules. With many tens of millions of both chemical structures and biological test results, PubChem is a sizeable system with an uneven degree of available information. Some chemical structures in PubChem include a great deal of biological annotation, while others have little to none. To help users, PubChem pre-computes "neighboring" relationships to relate similar chemical structures, which may have similar biological function. In this work, we introduce a "Similar Conformers" neighboring relationship to identify compounds with similar 3-D shape and similar 3-D orientation of functional groups typically used to define pharmacophore features. Results The first two diverse 3-D conformers of 26.1 million PubChem Compound records were compared to each other, using a shape Tanimoto (ST of 0.8 or greater and a color Tanimoto (CT of 0.5 or greater, yielding 8.16 billion conformer neighbor pairs and 6.62 billion compound neighbor pairs, with an average of 253 "Similar Conformers" compound neighbors per compound. Comparing the 3-D neighboring relationship to the corresponding 2-D neighboring relationship ("Similar Compounds" for molecules such as caffeine, aspirin, and morphine, one finds unique sets of related chemical structures, providing additional significant biological annotation. The PubChem 3-D neighboring relationship is also shown to be able to group a set of non-steroidal anti-inflammatory drugs (NSAIDs, despite limited PubChem 2-D similarity. In a study of 4,218 chemical structures of biomedical interest, consisting of many known drugs, using more diverse conformers per compound results in more 3-D compound neighbors per compound; however, the overlap of the compound neighbor lists per conformer also increasingly resemble each other, being 38% identical at three conformers and 68% at ten conformers. Perhaps surprising is that the average

  15. PubMed数据库检索

    Institute of Scientific and Technical Information of China (English)

    李蓓

    2007-01-01

    PubMed(http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed)是由美国国立医学图书馆国家生物技术信息中心开发的生命科学书目网络检索系统。该系统具有非常强大的检索和链接功能,是目前世界上查找医学文献利用率最高的网上免费数据库,学会利用PubMed,也可以触类旁通,掌握其他医学数据库的检索方法。

  16. Clubs, Pubs, and Models of Mantle Mixing

    Science.gov (United States)

    Advocate, Dev L.

    2008-08-01

    Next time you enter a pub, take a moment to ponder your pint and your place and their role in the history of the fluid sciences. Pint by pint, the fluid sciences, the precursors to geodynamics, were developed in the taprooms and clubs of the great nineteenth-century thinkers. They puffed their pipes, sipped their wine and ale, feasted on pies and porridge, satiating and saturating themselves in rising plumes of smoke and steam.

  17. The use of PubMed/Medline in psychiatry. 3: Searching PubMed.

    Science.gov (United States)

    Theander, Sten S

    2006-01-01

    This paper is the third in a series of three, intended as a tutorial in the use of PubMed/Medline for an inexperienced user. The papers have the following contents: I--a description of NLM, Medline, PubMed and the system of Medical Subject Headings (MeSH), which form the basis for the indexing of scientific articles, books and other items at NLM. II--A description and a tutorial of the PubMed search window. III--The present article deals mainly with the searching for references in PubMed. Ways of restricting and concentrating the search are presented, and exercises are proposed. A reader may also find guidance for a search for medical books in the NLM Catalog, and in the use of tools like Related Articles, Bookshelf, and Index. With eating disorders as an example, more information is presented on the use of MeSH terms.

  18. Costruzione ed uso di filtri per la valutazione delle tecnologie sanitarie in PubMed

    OpenAIRE

    Vidale, C; Guarrera, GM

    2013-01-01

    The staff of health services involved in the multidisciplinary assessment of health technologies is required to know its specific literature references, in addition to research reports and assessments produced by HTA agencies. Through PubMed can be identified citations of articles with the aim of multidisciplinary assessment of the technologies. Any interested person may obtain, by exploiting the potential of PubMed My NCBI and using sophisticated techniques for creating filters, a custom use...

  19. PubMed查询技巧探析%Skills in Searching PubMed

    Institute of Scientific and Technical Information of China (English)

    顾萍

    2005-01-01

    PubMed是国内外医学研究人员网上免费获取生物医学信息、查找循证医学证据的重要文献数据库系统.为帮助用户熟练使用PubMed,对其查询特点进行了分析研究.

  20. 3-Carb-oxy-methyl-1H-indole-4-carb-oxy-lic acid.

    Science.gov (United States)

    Mao, Shulin

    2012-01-01

    In the title compound, C(11)H(9)NO(4), the carboxyl group bonded to the six-membered ring lies close to the plane of the 1H-indole ring system [dihedral angle = 13.13 (9)°], whereas the carb-oxy-lic acid group linked to the five-membered ring by a methyl-ene bridge is close to perpendicular [78.85 (9)°]. In the crystal, O-H⋯O and N-H⋯O hydrogen bonds link the mol-ecules, generating (110) sheets.

  1. Rovibrational dynamics of LiCs dimers in strong electric fields

    Energy Technology Data Exchange (ETDEWEB)

    Gonzalez-Ferez, R. [Instituto ' Carlos I' de Fisica Teorica y Computacional and Departamento de Fisica Moderna, Universidad de Granada, E-18071 Granada (Spain)], E-mail: rogonzal@ugr.es; Mayle, M. [Theoretische Chemie, Physikalisch-Chemisches Institut, Im Neuenheimer Feld 229, D-69120 Heidelberg (Germany)], E-mail: Michael.Mayle@pci.uni-heidelberg.de; Schmelcher, P. [Theoretische Chemie, Physikalisch-Chemisches Institut, Im Neuenheimer Feld 229, D-69120 Heidelberg (Germany); Physikalisches Institut, Universitaet Heidelberg, Philosophenweg 12, D-69120 Heidelberg (Germany)], E-mail: Peter.Schmelcher@pci.uni-heidelberg.de

    2006-10-26

    We investigate the effects of a strong electric field on the rovibrational dynamics of LiCs in its {sup 1}{sigma}{sup +} electronic ground state. Using a hybrid computational technique combining discretisation and basis set methods, the rovibrational Schroedinger equation is solved. Results for energy levels and various expectation values are presented. The validity of the previous developed effective and adiabatic rotor approaches is investigated. The electric field-induced hybridization is analyzed up to high rotational excitations and for a large range of magnetic quantum numbers.

  2. Technical development of PubMed Interact: an improved interface for MEDLINE/PubMed searches

    Directory of Open Access Journals (Sweden)

    Fontelo Paul

    2006-11-01

    Full Text Available Abstract Background The project aims to create an alternative search interface for MEDLINE/PubMed that may provide assistance to the novice user and added convenience to the advanced user. An earlier version of the project was the 'Slider Interface for MEDLINE/PubMed searches' (SLIM which provided JavaScript slider bars to control search parameters. In this new version, recent developments in Web-based technologies were implemented. These changes may prove to be even more valuable in enhancing user interactivity through client-side manipulation and management of results. Results PubMed Interact is a Web-based MEDLINE/PubMed search application built with HTML, JavaScript and PHP. It is implemented on a Windows Server 2003 with Apache 2.0.52, PHP 4.4.1 and MySQL 4.1.18. PHP scripts provide the backend engine that connects with E-Utilities and parses XML files. JavaScript manages client-side functionalities and converts Web pages into interactive platforms using dynamic HTML (DHTML, Document Object Model (DOM tree manipulation and Ajax methods. With PubMed Interact, users can limit searches with JavaScript slider bars, preview result counts, delete citations from the list, display and add related articles and create relevance lists. Many interactive features occur at client-side, which allow instant feedback without reloading or refreshing the page resulting in a more efficient user experience. Conclusion PubMed Interact is a highly interactive Web-based search application for MEDLINE/PubMed that explores recent trends in Web technologies like DOM tree manipulation and Ajax. It may become a valuable technical development for online medical search applications.

  3. The PubChem chemical structure sketcher

    Directory of Open Access Journals (Sweden)

    Ihlenfeldt Wolf D

    2009-12-01

    Full Text Available Abstract PubChem is an important public, Web-based information source for chemical and bioactivity information. In order to provide convenient structure search methods on compounds stored in this database, one mandatory component is a Web-based drawing tool for interactive sketching of chemical query structures. Web-enabled chemical structure sketchers are not new, being in existence for years; however, solutions available rely on complex technology like Java applets or platform-dependent plug-ins. Due to general policy and support incident rate considerations, Java-based or platform-specific sketchers cannot be deployed as a part of public NCBI Web services. Our solution: a chemical structure sketching tool based exclusively on CGI server processing, client-side JavaScript functions, and image sequence streaming. The PubChem structure editor does not require the presence of any specific runtime support libraries or browser configurations on the client. It is completely platform-independent and verified to work on all major Web browsers, including older ones without support for Web2.0 JavaScript objects.

  4. Automatic Export of PubMed Citations to EndNote.

    Science.gov (United States)

    London, Sue; Gurdal, Osman; Gall, Carole

    2010-04-01

    The export of MEDLINE references to EndNote can be accomplished in various ways. Unlike Ovid MEDLINE, PubMed does not have a direct export feature to EndNote. Until recently, PubMed references had to be saved as a text file to import into EndNote. Now, the automatic export of PubMed references can be done using Internet Explorer (IE) or Mozilla Firefox Web browsers. The development and teaching of seamless citation management is a value-added service to health professionals.

  5. Crystal structure of benzene-1,3,5-tri-carb-oxy-lic acid-4-pyridone (1/3).

    Science.gov (United States)

    Staun, Selena L; Oliver, Allen G

    2015-11-01

    Slow co-crystallization of a solution of benzene-1,3,5-tri-carb-oxy-lic acid with a large excess of 4-hy-droxy-pyridine produces an inter-penetrating, three-dimensional, hydrogen-bonded framework consisting of three 4-pyridone and one benzene-1,3,5-tri-carb-oxy-lic acid mol-ecules, C9H6O6·3C5H5NO. This structure represents an ortho-rhom-bic polymorph of the previously reported C-centered, monoclinic structure [Campos-Gaxiola et al. (2014 ▸). Acta Cryst. E70, o453-o454].

  6. PubMed Medline 7: Gestionar els resultats. Gener 2011

    OpenAIRE

    2011-01-01

    També podeu consultar altres tutorials sobre el PubMed: 1. PubMed Medline: Accés, http://hdl.handle.net/2445/15122; 2. PubMed Medline: Cerca bàsica, http://hdl.handle.net/2445/15123; 3. PubMed Medline: Elements de cerca i límits, http://hdl.handle.net/2445/15124; 4. PubMed Medline: Matèries MeSH, http://hdl.handle.net/2445/15125; 5. PubMed Medline: Cerca avançada, http://hdl.handle.net/2445/15126; 6. PubMed Medline: Exemple de cerca avançada, http://hdl.handle.net/2445/15127; 8. PubMed Medli...

  7. A model for 'reverse innovation' in health care.

    Science.gov (United States)

    Depasse, Jacqueline W; Lee, Patrick T

    2013-08-30

    'Reverse innovation,' a principle well established in the business world, describes the flow of ideas from emerging to more developed economies. There is strong and growing interest in applying this concept to health care, yet there is currently no framework for describing the stages of reverse innovation or identifying opportunities to accelerate the development process. This paper combines the business concept of reverse innovation with diffusion of innovation theory to propose a model for reverse innovation as a way to innovate in health care. Our model includes the following steps: (1) identifying a problem common to lower- and higher-income countries; (2) innovation and spread in the low-income country (LIC); (3) crossover to the higher-income country (HIC); and (4) innovation and spread in the HIC. The crucial populations in this pathway, drawing from diffusion of innovation theory, are LIC innovators, LIC early adopters, and HIC innovators. We illustrate the model with three examples of current reverse innovations. We then propose four sets of specific actions that forward-looking policymakers, entrepreneurs, health system leaders, and researchers may take to accelerate the movement of promising solutions through the reverse innovation pipeline: (1) identify high-priority problems shared by HICs and LICs; (2) create slack for change, especially for LIC innovators, LIC early adopters, and HIC innovators; (3) create spannable social distances between LIC early adopters and HIC innovators; and (4) measure reverse innovation activity globally.

  8. Vol 38 2010 Art 6.pub

    African Journals Online (AJOL)

    p2613611

    ISSN 0378-5254 Journal of Family Ecology and Consumer Sciences, Vol 38, 2010 .... m only —foods which prom ote health beyond providing .... health conscious individuals may be motivated to process ...... Food industry forecast: Consumer.

  9. An overview of the PubChem BioAssay resource.

    Science.gov (United States)

    Wang, Yanli; Bolton, Evan; Dracheva, Svetlana; Karapetyan, Karen; Shoemaker, Benjamin A; Suzek, Tugba O; Wang, Jiyao; Xiao, Jewen; Zhang, Jian; Bryant, Stephen H

    2010-01-01

    The PubChem BioAssay database (http://pubchem.ncbi.nlm.nih.gov) is a public repository for biological activities of small molecules and small interfering RNAs (siRNAs) hosted by the US National Institutes of Health (NIH). It archives experimental descriptions of assays and biological test results and makes the information freely accessible to the public. A PubChem BioAssay data entry includes an assay description, a summary and detailed test results. Each assay record is linked to the molecular target, whenever possible, and is cross-referenced to other National Center for Biotechnology Information (NCBI) database records. 'Related BioAssays' are identified by examining the assay target relationship and activity profile of commonly tested compounds. A key goal of PubChem BioAssay is to make the biological activity information easily accessible through the NCBI information retrieval system-Entrez, and various web-based PubChem services. An integrated suite of data analysis tools are available to optimize the utility of the chemical structure and biological activity information within PubChem, enabling researchers to aggregate, compare and analyze biological test results contributed by multiple organizations. In this work, we describe the PubChem BioAssay database, including data model, bioassay deposition and utilities that PubChem provides for searching, downloading and analyzing the biological activity information contained therein.

  10. Ca2LiC3H: a new complex carbide hydride phase grown in metal flux.

    Science.gov (United States)

    Lang, David A; Zaikina, Julia V; Lovingood, Derek D; Gedris, Thomas E; Latturner, Susan E

    2010-12-15

    The reaction of carbon and CaH2 in a calcium/lithium flux mixture produces crystals of the new compound Ca2LiC3H. This phase forms with a new structure type in tetragonal space group P4/mbm (a = 6.8236(1) Å, c = 3.7518(1) Å, Z = 2, R1 = 0.0151). This is a stuffed variant of the Cs2(NH2)N3 structure, containing hydride anions in octahedral sites; the structure determination by single-crystal X-ray diffraction surprisingly allowed the hydrogen to be detected. The Ca2LiC3H structure also features the rarely seen C3(4-) carbide anion; the protolysis reaction of this compound with ammonium chloride produces C3H4. The electronic properties of Ca2LiC3H were studied by quantum-chemical calculations including band structure and electron localization function (ELF) analysis; the phase is a charge-balanced semiconductor with a calculated band gap of 0.48 eV. This is in agreement with (7)Li, (13)C, and (1)H MAS NMR data, which show resonances in the ionic region instead of the Knight shifted region. ELF analysis of the theoretical nonhydrided Ca2LiC3 structure confirms the ability of these calculations to properly locate hydrides and supports the structural model based on X-ray diffraction data.

  11. Optimization of the PubMed Automatic Term Mapping.

    Science.gov (United States)

    Thirion, Benoit; Robu, Ioana; Darmoni, Stéfan J

    2009-01-01

    PubMed, freely available on the internet, is the best known database for medical information. We propose a method of optimization of the PubMed Automatic Term Mapping (ATM) that includes MeSH terms. This method is evaluated using two queries constructed to emphasize the differences between the PubMed queries as they are at present and also between these queries and the optimized one. The proposed query is significantly more precise than the current PubMed query (54.5% vs. 27%). The optimized query proposed would be easy to implement into PubMed.

  12. PubMed新增功能评析%The New Fetures of PubMed

    Institute of Scientific and Technical Information of China (English)

    李朝葵; 游强华

    2009-01-01

    2008年以来,PubMed系统不仅改进了其自动词语匹配功能(ATM),还新推出了高级检索模式(Advanced Search),强化了个性化服务功能(My NCBI),本文就这些新功能进行了简要的介绍与分析.

  13. Bancos de Esporos de Samambaias e Licófitas: uma Revisão

    Directory of Open Access Journals (Sweden)

    Luciano Mauricio Esteves

    2013-01-01

    Full Text Available Os esporos de samambaias e licófitas podem ser depositados no solo e podem ser levados para o seu interior por mecanismos diversos, em geral para as camadas superficiais. Aí eles podem permanecer por determinado período de tempo em estado dormente e, quando levados novamente à superfície, poderão germinar. Esses esporos vivos armazenados no solo são chamados de banco de esporos. Bancos de esporos podem reduzir o risco de extinção de espécies, permitindo a regeneração de uma população devastada por inundações, incêndios, secas, deslizamentos ou processos de sucessão. Desta forma, eles têm uma função semelhante ao dos bancos de sementes em espermatófitas. A maioria absoluta dos esporos de samambaias e licófitas são fotoblásticos positivos. Esse valor adaptativo os torna dormentes quando soterrados e potencialmente aptos para germinar quando trazidos à luz. A regeneração de bancos de esporos persistentes também pode aumentar as chances de cruzamento entre gametófitos de espécies colonizadoras. Funciona como um tampão contra as consequências da baixa produção de esporos nos anos com condições climáticas adversas e contra mudanças drásticas na composição genética durante as flutuações no tamanho da população, de modo que somente a longo prazo os padrões ambientais podem alterar substancialmente essa composição. Genótipos aparentemente perdidos podem ser recuperados a partir do banco de esporos.

  14. Revolution of peer review-PubMed Commons%同行评议的革命-PubMed Commons

    Institute of Scientific and Technical Information of China (English)

    陈莹

    2014-01-01

    介绍了加入PubMed Commons的3种途径以及使用PubMed Commons添加、回复和分享评论的方法,为用户更快地掌握PubMed Commons的使用方法提供帮助,指出了PubMed开放评论的意义。%Three methods to become a member of PubMed Commons and the ways to add, reply and share reviews using PubMed Commons were described in order to help its users to master how to use it, and the significance of PubMed open reviews was pointed out.

  15. Improvement of PubMed Literature Searching using Biomedical Ontology

    OpenAIRE

    Zuoshuang Xiang; Yongqun He

    2009-01-01

    PubMed articles are annotated using the Medical Subject Headings (MeSH) to increase search efficiency. However, MeSH contains limited information on many biomedical domains (e.g., vaccine). Biomedical ontologies may be used to improve PubMed searching capability. This study demonstrates that Vaccine Ontology (VO) can be used to significantly improve PubMed searching efficacy in the vaccine domain. The recall and precision of the ontology-based literature mining approach are analyzed and discu...

  16. (Quinoline-2-carboxyl-ato-κO)(quinoline-2-carb-oxy-lic acid-κO)bis-(quinoline-2-carb-oxy-lic acid-κN,O)potassium.

    Science.gov (United States)

    Ng, Seik Weng

    2010-07-17

    The K atom in the title complex, [K(C(10)H(6)NO(2))(C(10)H(7)NO(2))(3)], lies on a twofold rotation axis that relates one N,O-chelating quinoline-2-carb-oxy-lic acid to the other; their N and O atoms are cis to each other in the distorted octa-hedral coordination geometry. The K atom is also coordinated by another monodentate quinoline-2-carb-oxy-lic acid; the acid is disordered with respect to a monodentate quinoline-2-carboxyl-ate anion; the acid and anion are linked by an O-H⋯O hydrogen bond. An O-H⋯N hydrogen bond links adjacent mol-ecules into a linear chain structure along the a axis.

  17. (1H-Benzimidazole-5-carb-oxy-lic acid-κN)(1H-benzimidazole-6-carb-oxy-lic acid-κN)silver(I) perchlorate.

    Science.gov (United States)

    Ma, Li; Huang, Yu-Hua; Xu, Jian-Feng; Deng, Hong

    2011-04-01

    The reaction of 1H-benzimidazole-5-carb-oxy-lic acid with silver nitrate in the presence of perchloric acid under hydro-thermal conditions yielded the title complex, [Ag(C(8)H(6)N(2)O(2))(2)]ClO(4), which comprises of an [Ag(C(8)H(6)N(2)O(2))(2)] mononuclear cation and a perchlorate anion. The Ag(I) ion is coordinated by two N atoms from two different neutral 1H-benzimidazole-5-carb-oxy-lic acid ligands with an N-Ag-N bond angle of 163.21 (14)°, forming an [Ag(C(8)H(6)N(2)O(2))(2)] mononuclear cation. Although both ligands in the mononuclear cation are monodentate with one N atom coordinated to the metal ion, they are different: one is N(3) coordinated to the Ag (I) ion and the N(1) atom protonated, the other with the N(1) coordinated to the Ag (I) ion and the N(3) atom protonated (and thus formally a 1H-benzimidazole-6-carb-oxy-lic acid rather than a 1H-benzimidazole-5-carb-oxy-lic acid ligand). The planes of the two planar ligands are roughly perpendicular, making a dihedral angle of 84.97 (2)°. The packing of the ions is stablized by extensive O-H⋯O, N-H⋯O and C-H⋯O hydrogen bonds, and by remote Ag⋯O inter-actions [3.002 (3), 3.581 (5) and 3.674 (5) Å].

  18. PubMed QUEST: The PubMed Query Search Tool. An informatics tool to aid cancer centers and cancer investigators in searching the PubMed databases

    Directory of Open Access Journals (Sweden)

    David A. Hanauer

    2006-01-01

    Full Text Available Searching PubMed for citations related to a specific cancer center or group of authors can be labor-intensive. We have created a tool, PubMed QUEST, to aid in the rapid searching of PubMed for publications of interest. It was designed by taking into account the needs of entire cancer centers as well as individual investigators. The experience of using the tool by our institution’s cancer center administration and investigators has been favorable and we believe it could easily be adapted to other institutions. Use of the tool has identified limitations of automated searches for publications based on an author’s name, especially for common names. These limitations could likely be solved if the PubMed database assigned a unique identifier to each author

  19. Vol 37 2009 Art 5.pub

    African Journals Online (AJOL)

    user

    past ten years, child health has deteriorated (Bourne et al, 2007). ... the problem , as opposed to the short-term solution of supplementation (Hallberg ... and seven years old, in the Vaal region. The specific .... 4 7 ,7. 8 4 ,9 á. 0,000. T he main fu nc tion of protein foods is to b u ild mu sc les. 51 ,7. 7 3 ,2 á .... Memory retention.

  20. Robust Inclusion Complexes of Crown Ether Fused Tetrathiafulvalenes with Li+@C-60 to Afford Efficient Photodriven Charge Separation

    DEFF Research Database (Denmark)

    Supur, M.; Kawashima, Y.; Larsen, K. R.;

    2014-01-01

    ) obtained by UV/Vis titrations in benzonitrile (PhCN) at room temperature. On the basis of DFT studies at the B3LYP/6-311G(d,p) level, the orbital interactions between the crown ether moieties and the p surface of the fullerene together with the endohedral Li+ have a crucial role in robust complex formation...... for 1 center dot Li+@C-60 and 2 center dot Li+@C-60, respectively, and quantum yields of 0.82 in PhCN have been observed by utilizing time-resolved transient absorption spectroscopy and then confirmed by electron paramagnetic resonance measurements at 4 K. The difference in crown ether structures...

  1. Expanding methods of PubMed subsets%扩充PubMed子集种类的方法

    Institute of Scientific and Technical Information of China (English)

    孙风梅

    2012-01-01

    针对目前PubMed数据库子集种类有限和部分读者在检索PubMed时没有适合本学科的子集进行限定的问题,提出了扩充PubMed子集种类的方法,帮助不同专业的读者快速准确地检索到本学科的文献.

  2. PubFocus: semantic MEDLINE/PubMed citations analytics through integration of controlled biomedical dictionaries and ranking algorithm

    Directory of Open Access Journals (Sweden)

    Chuong Cheng-Ming

    2006-10-01

    Full Text Available Abstract Background Understanding research activity within any given biomedical field is important. Search outputs generated by MEDLINE/PubMed are not well classified and require lengthy manual citation analysis. Automation of citation analytics can be very useful and timesaving for both novices and experts. Results PubFocus web server automates analysis of MEDLINE/PubMed search queries by enriching them with two widely used human factor-based bibliometric indicators of publication quality: journal impact factor and volume of forward references. In addition to providing basic volumetric statistics, PubFocus also prioritizes citations and evaluates authors' impact on the field of search. PubFocus also analyses presence and occurrence of biomedical key terms within citations by utilizing controlled vocabularies. Conclusion We have developed citations' prioritisation algorithm based on journal impact factor, forward referencing volume, referencing dynamics, and author's contribution level. It can be applied either to the primary set of PubMed search results or to the subsets of these results identified through key terms from controlled biomedical vocabularies and ontologies. NCI (National Cancer Institute thesaurus and MGD (Mouse Genome Database mammalian gene orthology have been implemented for key terms analytics. PubFocus provides a scalable platform for the integration of multiple available ontology databases. PubFocus analytics can be adapted for input sources of biomedical citations other than PubMed.

  3. Projecte constructiu d'un parc eòlic al Coll de Poca sang (Colera, Alt Empordà)

    OpenAIRE

    Planas Bosch, Lluis

    2013-01-01

    Construcció d'un parc eòlic a la Ribera de Molinars, entre el Parc Natural d'Albera i el municipi de Colera. La direcció de la ribera és Oest-Est i això propicia que els molins estiguin encarats al vent de Tramuntana. La ribera desemboca creuant pel mig el municipi de Colera. Subjecte a Medi Ambient, el projecte requereix un Estudi d'impacte ambiental (zona groga).

  4. SU-E-T-105: The LET Dependence of Liquid Ionization Chambers (LICs) in High-LET Beams.

    Science.gov (United States)

    Tegami, S; Gomez, F; Gónzales-Castaño, D; Jaekel, O; Pardo-Montero, J; Holzscheiter, M

    2012-06-01

    LICs are novel detectors for radiotherapy: the higher density of the medium allows to build them with a smaller sensitive volume, making them appealing in particle therapy. With RBE varying along the depth dose curve (DDC) and with the rising interest in dose/LET-painting, verifying the LET is becoming more important. Nevertheless, while the LET distributions for different ionizing particles have been calculated, they have never been directly measured in realistic therapeutic beams. Our interest in LICs is based on the characterization of the beam quality in terms of LET. It has been shown in earlier works that the extrapolation of the linear portion of the voltage curve yields an intercept with the x-axis that depends on LET. The quantitative establishment of this method, however, depends on how accurately recombination effects are taken into account. Due to the higher density of charge carriers produced in the liquid, LICs have high recombination effects: general recombination effects, involving pairs belonging to different tracks (dose rate dependent), and initial recombination between ion-electron pairs belonging to the same incident particle event (LET dependent). To perform this study we propose a two-dimensional array of LICs, composed by a 16×8 matrix of 2×2 mm(2) pixels, which gives a fine spatial resolution on the plane. Voltage curves have been measured for proton, carbon and oxygen beams available at the HIT facility in Heidelberg for different energies and dose rates. After correcting the curves for general recombination losses using the Three Voltage Method, we have indications of dose rate independence, indicating successful correction. Further investigations are foreseen to quantify the LET dependence along the DDC, where different LET values are expected. A comparison with simulated dose averaged LET values will give quantitative information about 2D LET distributions for different beam species. © 2012 American Association of Physicists in

  5. Proteína LIC10494 de Leptospira interrogans serovar Copenhageni: modelo estructural y regiones funcionales asociadas

    Directory of Open Access Journals (Sweden)

    Orlando Emilio Acevedo

    2012-04-01

    Full Text Available Protein LIC10494 of Leptospira interrogans serovar Copenhageni: structural model and associated functional regions. Objective.Predict by computational means the 3D structure of the antigenic protein LIC10494 and report associated important functional regionsfor its pathogenicity and immunogenicity. Materials and methods. We performed a computational analysis of the primary structure ofLIC10494 using the servers BLAST, PROTPARAM, PROTSCALE, DAS, SOSUI, TOPPRED, TMAP, TMpred, SPLIT4, PHDHTM,TMHMM2, HMMTOP2, GLOBPLOT and PROSITE. The secondary structure was obtained by consensus of the algorithms SOPM,PREDATOR GOR4, DPM and DSC. The approach to the tertiary structure was obtained using the algorithm MUSTER. The energyminimization was done using the AMBER94 force field of the Schrodinger suite of molecular analysis, and the stereochemistry andenergy model validation was performed by the RAMPAGE server. The final model was visualized using PyMol V.0,98. Results. Thisstudy proposes a computational model that describes the 3D structure of the hypothetical lipoprotein LIC10494 and agrees with previousexperimental reports; thus, our study demonstrates the existence of patterns that could play an important role in the pathogenicity andprotection of the bacteria against the host immune system; the presence of a disorganized region between amino acids 80 and 140, andof a transmembrane segment between amino acids 8 and 22. Conclusion. The coincidence between structural and functional segments suggests that our model can be used to predict certain aspects of the biological behaviour of the protein according to the pathogenic andimmunogenic characteristics of the bacteria.

  6. Bosnian and Herzegovinian medical scientists in PubMed database.

    Science.gov (United States)

    Masic, Izet

    2013-01-01

    In this paper it is shortly presented PubMed as one of the most important on-line databases of the scientific biomedical literature. Also, the author has analyzed the most cited authors, professors of the medical faculties in Bosnia and Herzegovina, from the published papers in the biomedical journals abstracted and indexed in PubMed.

  7. PubChem BioAssay: 2017 update

    Science.gov (United States)

    Wang, Yanli; Bryant, Stephen H.; Cheng, Tiejun; Wang, Jiyao; Gindulyte, Asta; Shoemaker, Benjamin A.; Thiessen, Paul A.; He, Siqian; Zhang, Jian

    2017-01-01

    PubChem's BioAssay database (https://pubchem.ncbi.nlm.nih.gov) has served as a public repository for small-molecule and RNAi screening data since 2004 providing open access of its data content to the community. PubChem accepts data submission from worldwide researchers at academia, industry and government agencies. PubChem also collaborates with other chemical biology database stakeholders with data exchange. With over a decade's development effort, it becomes an important information resource supporting drug discovery and chemical biology research. To facilitate data discovery, PubChem is integrated with all other databases at NCBI. In this work, we provide an update for the PubChem BioAssay database describing several recent development including added sources of research data, redesigned BioAssay record page, new BioAssay classification browser and new features in the Upload system facilitating data sharing. PMID:27899599

  8. APM杂志被PubMed/MEDLINE收录

    Institute of Scientific and Technical Information of China (English)

    钟清华

    2015-01-01

    Annals of Palliative Medicine(《姑息医学年鉴》,简称APM杂志),于2015年3月11日被PubMed/MEDLINE收录。目前,AME旗下12本杂志被PubMed收录(10本被PubMed Central(PMC)全文收录,2本被MEDLINE收录)。MEDLINE始于1960年,是PubMed最重要的组成部分。PubMed由美国健康研究院(NIH)提供支持,已成为写作者最常使用的索引工具,而其拥有的2300万条索引中,

  9. Using PubMed effectively to access the orthopaedic literature.

    Science.gov (United States)

    Clough, J F Myles; Hitchcock, Kristin; Nelson, David L

    2011-01-01

    PubMed is the free public Internet interface to the US National Library of Medicine's MEDLINE database of citations to medical scientific articles. Many orthopaedic surgeons use PubMed on a regular basis, but most orthopaedic surgeons have received little or no training in how to use PubMed effectively and express frustration with the experience. Typical problems encountered are data overload with very large numbers of returns to look through, failure to find a specific article, and a concern that a search has missed important papers. It is helpful to understand the system used to enter journal articles into the database and the classification of the common types of searches and to review suggestions for the best ways to use the PubMed interface and find sources for search teaching and assistance.

  10. AliBaba: PubMed as a graph

    National Research Council Canada - National Science Library

    Plake, Conrad; Schiemann, Torsten; Pankalla, Marcus; Hakenberg, Jörg; Leser, Ulf

    2006-01-01

    .... AliBaba is an interactive tool for graphical summarization of search results. It parses the set of abstracts that fit a PubMed query and presents extracted information on biomedical objects and their relationships as a graphical network...

  11. PubMed检索方法与技巧

    Institute of Scientific and Technical Information of China (English)

    朱亨范

    2007-01-01

    目前,PubMed已经成为国内医药卫生工作者使用的主要外文文献检索数据库。本文对PubMed的结构及检索方法与技巧作了介绍,旨在帮助读者更好地加以利用。

  12. Comparison of PubMed and Google Scholar literature searches.

    Science.gov (United States)

    Anders, Michael E; Evans, Dennis P

    2010-05-01

    Literature searches are essential to evidence-based respiratory care. To conduct literature searches, respiratory therapists rely on search engines to retrieve information, but there is a dearth of literature on the comparative efficiencies of search engines for researching clinical questions in respiratory care. To compare PubMed and Google Scholar search results for clinical topics in respiratory care to that of a benchmark. We performed literature searches with PubMed and Google Scholar, on 3 clinical topics. In PubMed we used the Clinical Queries search filter. In Google Scholar we used the search filters in the Advanced Scholar Search option. We used the reference list of a related Cochrane Collaboration evidence-based systematic review as the benchmark for each of the search results. We calculated recall (sensitivity) and precision (positive predictive value) with 2 x 2 contingency tables. We compared the results with the chi-square test of independence and Fisher's exact test. PubMed and Google Scholar had similar recall for both overall search results (71% vs 69%) and full-text results (43% vs 51%). PubMed had better precision than Google Scholar for both overall search results (13% vs 0.07%, P Advanced Scholar Search in Google Scholar for respiratory care topics. PubMed appears to be more practical to conduct efficient, valid searches for informing evidence-based patient-care protocols, for guiding the care of individual patients, and for educational purposes.

  13. PubMed searches: overview and strategies for clinicians.

    Science.gov (United States)

    Lindsey, Wesley T; Olin, Bernie R

    2013-04-01

    PubMed is a biomedical and life sciences database maintained by a division of the National Library of Medicine known as the National Center for Biotechnology Information (NCBI). It is a large resource with more than 5600 journals indexed and greater than 22 million total citations. Searches conducted in PubMed provide references that are more specific for the intended topic compared with other popular search engines. Effective PubMed searches allow the clinician to remain current on the latest clinical trials, systematic reviews, and practice guidelines. PubMed continues to evolve by allowing users to create a customized experience through the My NCBI portal, new arrangements and options in search filters, and supporting scholarly projects through exportation of citations to reference managing software. Prepackaged search options available in the Clinical Queries feature also allow users to efficiently search for clinical literature. PubMed also provides information regarding the source journals themselves through the Journals in NCBI Databases link. This article provides an overview of the PubMed database's structure and features as well as strategies for conducting an effective search.

  14. LIVER IRON CONTENT (LIC IN ADULTS WITH NON-TRANSFUSION DEPENDENT SICKLE CELL DISEASE (NT-SCD. CORRELATION WITH SERUM FERRITIN AND LIVER ENZYMES CONCENTRATIONS

    Directory of Open Access Journals (Sweden)

    Vincenzo De Sanctis

    2017-06-01

    Full Text Available Abstract. Introduction: Sickle cell disease (SCD is an important cause of morbidity and mortality worldwide, causing damage and dysfunction in multiple organs. The complications of this disease are numerous, affect every organ and/or tissue in the body and vary considerably among patients over the time which challenge its management. Aim of our study: To determine the iron status of 17 patients with NT-SCD patients and 6 patients with TD- SCD using both serum ferritin level (SF and Ferriscan® evaluation of liver iron content (LIC and correlate values of LIC on the one hand with SF levels and some hepatic functions (ALT, AST, ALP and albumin.  Results: 17 adults with NT-SCD (n = 17, age: 32±15 years were studied.  Seven of NT-SCD had serum ferritin > 500 μg/L, 4 out of the seven had high liver iron measured by FerriScan®  (> 30 mg/kg/ tissue dry weight - DW.  Two patients had high liver iron content despite a concomitant serum ferritin concentration < 500 μg/L.  Two patients had high serum ferritin (1.117 μg/L and 675 μg/L while their LIC was normal (< 30 mg/kg/DW.  5 patients had elevated ALT and/or AST concentrations. In TD-SCD (n = 6, age = 25 ±11 years, 2 patients had serum ferritin <500 μg/L, one of them had high LIC (127 mg/kg/DW. Liver enzymes were high in two patients.  Serum ferritin concentration was correlated significantly with LIC  (r = 0.85, p < 0.001. Neither serum ferritin level, nor LIC was correlated significantly with hepatic enzyme levels. Conclusions:  A significant number of our patients with ND-SCD had high LIC , high serum ferritin and elevated hepatic enzymes (ALT and AST. Despite some  limitations of our study (small NT-SCD cohort,  these findings have important clinical implications. We recommend  to measure serum ferritin and LIC in NT-SCD patients to apply therapeutic preventive measures with iron chelation therapy in patients with high LIC.

  15. An Analysis of Database Construction on PubMed%PubMed数据库建设探析

    Institute of Scientific and Technical Information of China (English)

    葛红梅; 徐晶晶; 董鹏; 周琴; 任慧玲

    2015-01-01

    PubMed数据库是世界公认的最有影响力的医学专业数据库.本文从数据库建设的角度,分析PubMed数据库的收录标准、数据处理流程、基础数据整合、深度标引等,以期对国内数据库建设有一定的借鉴意义.%PubMed database is recognized as the world's most influential medical database. This paper focuses on the analysis of NLM's PubMed database from the perspective of database construction, concerning its inclusion criteria, data processing procedures, data sources, data submission, metadata standards, and deep indexing, with the purpose of using its experience for the reference of domestic database construction.

  16. Crystal structure of [1,1':3',1''-ter-phenyl]-2',3,3''-tri-carb-oxy-lic acid.

    Science.gov (United States)

    Decato, Daniel A; Berryman, Orion B

    2015-09-01

    The asymmetric unit of the title compound, C21H14O6, com-prises two symmetrically independent mol-ecules that form a locally centrosymmetric hydrogen-bonded dimer, with the planes of the corresponding carb-oxy-lic acid groups rotated by 15.8 (1) and 17.5 (1)° relative to those of the adjacent benzene rings. The crystal as a whole, however, exhibits a noncentrosymmetric packing, described by the polar space group Pca21. The dimers form layers along the ab plane, being inter-connected by hydrogen bonds involving the remaining carb-oxy-lic acid groups. The plane of the central carb-oxy-lic acid group forms dihedral angles of 62.5 (1) and 63.0 (1)° with those of the adjacent benzene rings and functions as a hydrogen-bond donor and acceptor. As a donor, it inter-connects adjacent layers, while as an acceptor it stabilizes the packing within the layers. The 'distal' carb-oxy-lic acid groups are nearly coplanar with the planes of the adjacent benzene rings, forming dihedral angles of 1.8 (1) and 7.1 (1)°. These groups also form intra- and inter-layer hydrogen bonds, but with 'reversed' functionality, as compared with the central carb-oxy-lic acid groups.

  17. [Prevalence of enteral patients with suboptimal feeding at Centro Medico Lic. Adolfo Lopez Mateos].

    Science.gov (United States)

    Baca Molina, Giovanna Paola; Peña Corona, Maribel

    2015-04-01

    Antecedentes y Objetivo: En México, el 64% de los pacientes hospitalizados sufren de desnutrición hospitalaria y hasta un 100% en adultos mayores, se han estudiado las causas, entre ellas se destacan: la sub-alimentación, el tiempo de hospitalización, el catabolismo presente en diversas patologías, falta de interés o tiempo del personal que labora en los hospitales entre otras. El objetivo del presente trabajo fue obtener la prevalencia de sub-alimentación en los pacientes hospitalizados con soporte enteral, en el Centro Médico “Lic. Adolfo López Mateos” (CMLALM) durante el periodo Agosto – Octubre 2014. Metodología: Se diseñó un estudio observacional, transversal, descriptivo; con una población de 52 pacientes con soporte enteral en el que se analizó la prevalencia de pacientes con sub-alimentación a partir de la ministración de la dieta enteral y la prescripción nutricional calórica establecida, durante el periodo de Agosto – Octubre 2014. Resultados: Se realizaron medidas de tendencia central para obtener el porcentaje de pacientes con sub-alimentación calórica. La prevalencia de pacientes con sub-alimentación fue del 71%, con mayor predominio el sexo masculino (70%) y en un rango de edad entre 51 años y 61 años (43%). El servicio médico de hospitalización donde se encontró la mayor prevalencia de pacientes con sub-alimentación fue medicina interna afectando a 14 pacientes (38%), seguido de neurocirugía con 7 pacientes (19%) y unidad de cuidados intensivos (UCI) con 7 pacientes (19%); siendo el turno nocturno donde se presentó en mayor predominio la sub-alimentación. Conclusiones: La sub-alimentación afectó a 37 pacientes con soporte enteral los cuales representan el 71% de la población estudiada, esta cifra coincide con otros estudios similares. La causa principal de la sub-alimentación fue el incumplimiento en la ministración de la dieta enteral.

  18. The Relation between Iranian Medical Science Research in PubMed and Burden of Disease

    Science.gov (United States)

    Foroughi, Zahra; Siamian, Hasan; Alizadeh-Navaei, Reza; Davodi, Ali

    2016-01-01

    Introduction: Scientific productions have been accelerated in Iran in past decades but its association with health problems and disease burden is doubtful. The aim of this study is assessment of the relationship between scientific productions with disease burden in Iran in PubMed dataset during 2010 to 2014. Method: The study was performed with the library method. Data Gathered using Scientometrics indicators and direct observation. The current research includes all articles written by Iranian researchers during 2010 to 2014 which were published in PubMed–indexed journals. The search was performed using keywords included road accident, ischaemic heart diseases, major depression disorders and cerebral vascular diseases. Results: In total 910 articles had been published PubMed -indexed journals. Among them Substance-Related Disorders and Accidents, Traffic had the highest (263 records) and lowest (94 records) records respectively. There was not a direct correlation between Years of Life Lost, Years Lost due to Disability and mortality rate with scientific productions. Conclusions: our results showed Iranian scientific productions in PubMed data set are not related to disease burden however they are not related to high mortality diseases. PMID:27708491

  19. The Relation between Iranian Medical Science Research in PubMed and Burden of Disease.

    Science.gov (United States)

    Foroughi, Zahra; Siamian, Hasan; Alizadeh-Navaei, Reza; Davodi, Ali

    2016-07-16

    Scientific productions have been accelerated in Iran in past decades but its association with health problems and disease burden is doubtful. The aim of this study is assessment of the relationship between scientific productions with disease burden in Iran in PubMed dataset during 2010 to 2014. The study was performed with the library method. Data Gathered using Scientometrics indicators and direct observation. The current research includes all articles written by Iranian researchers during 2010 to 2014 which were published in PubMed-indexed journals. The search was performed using keywords included road accident, ischaemic heart diseases, major depression disorders and cerebral vascular diseases. In total 910 articles had been published PubMed -indexed journals. Among them Substance-Related Disorders and Accidents, Traffic had the highest (263 records) and lowest (94 records) records respectively. There was not a direct correlation between Years of Life Lost, Years Lost due to Disability and mortality rate with scientific productions. our results showed Iranian scientific productions in PubMed data set are not related to disease burden however they are not related to high mortality diseases.

  20. Multi-lingual search engine to access PubMed monolingual subsets: a feasibility study.

    Science.gov (United States)

    Darmoni, Stéfan J; Soualmia, Lina F; Griffon, Nicolas; Grosjean, Julien; Kerdelhué, Gaétan; Kergourlay, Ivan; Dahamna, Badisse

    2013-01-01

    PubMed contains many articles in languages other than English but it is difficult to find them using the English version of the Medical Subject Headings (MeSH) Thesaurus. The aim of this work is to propose a tool allowing access to a PubMed subset in one language, and to evaluate its performance. Translations of MeSH were enriched and gathered in the information system. PubMed subsets in main European languages were also added in our database, using a dedicated parser. The CISMeF generic semantic search engine was evaluated on the response time for simple queries. MeSH descriptors are currently available in 11 languages in the information system. All the 654,000 PubMed citations in French were integrated into CISMeF database. None of the response times exceed the threshold defined for usability (2 seconds). It is now possible to freely access biomedical literature in French using a tool in French; health professionals and lay people with a low English language may find it useful. It will be expended to several European languages: German, Spanish, Norwegian and Portuguese.

  1. Gaps in affiliation indexing in Scopus and PubMed.

    Science.gov (United States)

    Schmidt, Cynthia M; Cox, Roxanne; Fial, Alissa V; Hartman, Teresa L; Magee, Martha L

    2016-04-01

    The authors sought to determine whether unexpected gaps existed in Scopus's author affiliation indexing of publications written by the University of Nebraska Medical Center or Nebraska Medicine (UNMC/NM) authors during 2014. First, we compared Scopus affiliation identifier search results to PubMed affiliation keyword search results. Then, we searched Scopus using affiliation keywords (UNMC, etc.) and compared the results to PubMed affiliation keyword and Scopus affiliation identifier searches. We found that Scopus's records for approximately 7% of UNMC/NM authors' publications lacked appropriate UNMC/NM author affiliation identifiers, and many journals' publishers were supplying incomplete author affiliation information to PubMed. Institutions relying on Scopus to track their impact should determine whether Scopus's affiliation identifiers will, in fact, identify all articles published by their authors and investigators.

  2. Crystal structure of a 2:1 co-crystal of meloxicam with acetyl-endi-carb-oxy-lic acid.

    Science.gov (United States)

    Tantardini, Christian; Arkhipov, Sergey G; Cherkashina, Ksenya A; Kil'met'ev, Alexander S; Boldyreva, Elena V

    2016-12-01

    The pharmaceutical 2:1 co-crystal of meloxicam [MXM; systematic name: 4-hy-droxy-2-methyl-N-(5-methyl-thia-zol-2-yl)-2H-1,2-benzo-thia-zine-3-carboxamide 1,1-dioxide] with acetyl-enedi-carb-oxy-lic acid (ACA; systematic name: but-2-ynedioic acid), crystallizes with one MXM mol-ecule and half an ACA mol-ecule in the asymmetric unit, C14H13N3O4S2·0.5C4H2O4. The mid-point of the triple bond of ACA is located on an inversion centre. In the crystal, the two stereoisomers of MXM with respect to the N atom of the sulfonamide group are related by the inversion centre. The carbonyl and hy-droxy groups belonging to the MXM mol-ecule are involved in an intra-molecular O-H⋯O hydrogen bond. The structure-forming motif includes two MXM mol-ecules linked via an ACA conformer through N-H⋯O and O-H⋯N hydrogen bonds, similar to MXM co-crystals with other di-carb-oxy-lic acids.

  3. 利用PubMed的E-Utilities工具构建PubMed拟投稿期刊选择模型%Constructing Proposed PubMed Journal Submission Choice Model with E-Utilities Tools in PubMed

    Institute of Scientific and Technical Information of China (English)

    王琳

    2011-01-01

    随着国际科技交流的日益广泛及研究评价中对学术出版要求的不断提高,我国有越来越多的科研人员期望能在国际性学术期刊上发表论文,为了提高向国外期刊投稿命中率,笔者利用PubMed的E-Utilities工具构建了PubMed拟投稿期刊选择模型,以供读者参考使用.

  4. 英国PubMed entral启动

    Institute of Scientific and Technical Information of China (English)

    李忠霞(编译)

    2007-01-01

    2007年1月8日,英国PubMed Central启动。以后科研人员可以获取到大量生命医学的研究资源,并能提交自己的出版作品。基于美国卫生部目前使用的模型,英国PubMed Central(UKPMC)将提供对医学和生命科学领域、经同行评议的研究成果的永久在线存档的免费获取。

  5. Crystal structure of (2S,4S)-5,5-dimethyl-2-(pyridin-2-yl)-1,3-thia-zolidine-4-carb-oxy-lic acid.

    Science.gov (United States)

    Laskar, Payel; Kuwamura, Naoto; Yoshinari, Nobuto; Konno, Takumi

    2014-12-01

    In the title compound, C11H14N2O2S, the thia-zolidine ring has an envelope conformation with the C atom bonded to the carb-oxy-lic acid group at the flap. Two C atoms of the thia-zolidine ring adopt S conformations. In the crystal, O-H⋯N hydrogen bonds between the amine and carb-oxy-lic acid groups construct a helical chain structure along the a-axis direction. The chains are further connected via weak C-H⋯π contacts, forming a layer parallel to the ac plane.

  6. Concern noted: A descriptive study of editorial expressions of concern in PubMed and PubMed Central.

    Science.gov (United States)

    Vaught, Melissa; Jordan, Diana C; Bastian, Hilda

    2017-01-01

    An editorial expression of concern (EEoC) is issued by editors or publishers to draw attention to potential problems in a publication, without itself constituting a retraction or correction. We searched PubMed, PubMed Central (PMC), and Google Scholar to identify EEoCs issued for publications in PubMed and PMC up to 22 August 2016. We also searched the archives of the Retraction Watch blog, some journal and publisher websites, and studies of EEoCs. In addition, we searched for retractions of EEoCs and affected articles in PubMed up to 8 December 2016. We analyzed overall historical trends, as well as reported reasons and subsequent editorial actions related to EEoCs issued between August 2014 and August 2016. After screening 5,076 records, we identified 230 EEoCs that affect 300 publications indexed in PubMed, the earliest issued in 1985. Half of the primary EEoCs were issued between 2014 and 2016 (52%). We found evidence of some EEoCs that had been removed by the publisher without leaving a record and some were not submitted for PubMed or PMC indexing. A minority of publications affected by EEoCs had been retracted by early December 2016 (25%). For the subset of 92 EEoCs issued between August 2014 and August 2016, affecting 99 publications, the rate of retraction was similar (29%). The majority of EEoCs were issued because of concerns with validity of data, methods, or interpretation of the publication (68%), and 31% of cases remained open. Issues with images were raised in 40% of affected publications. Ongoing monitoring after the study identified another 17 EEoCs to year's end in 2016, increasing the number of EEoCs to 247 and publications in PubMed known to be affected by EEoCs to 320 at the end of 2016. EEoCs have been rare publishing events in the biomedical literature, but their use has been increasing. Most have not led to retractions, and many remain unresolved. Lack of prominence and inconsistencies in management of EEoCs reduce the ability of these

  7. Biomedical information form PubMed%PubMed检索网上的生物医学信息

    Institute of Scientific and Technical Information of China (English)

    张卫

    2002-01-01

    PubMed是美国国立医学图书馆附属国立生物技术信息中心研制的免费生物医学数据库.本文介绍了PubMed的收录范围,检索方法、功能和特点.并就基本检索,期刊浏览,医学主题词浏览,引文匹配,临床问题等检索方式作了较详细的阐述.

  8. PubMatrix: a tool for multiplex literature mining

    Directory of Open Access Journals (Sweden)

    Bright Tiffani J

    2003-12-01

    Full Text Available Abstract Background Molecular experiments using multiplex strategies such as cDNA microarrays or proteomic approaches generate large datasets requiring biological interpretation. Text based data mining tools have recently been developed to query large biological datasets of this type of data. PubMatrix is a web-based tool that allows simple text based mining of the NCBI literature search service PubMed using any two lists of keywords terms, resulting in a frequency matrix of term co-occurrence. Results For example, a simple term selection procedure allows automatic pair-wise comparisons of approximately 1–100 search terms versus approximately 1–10 modifier terms, resulting in up to 1,000 pair wise comparisons. The matrix table of pair-wise comparisons can then be surveyed, queried individually, and archived. Lists of keywords can include any terms currently capable of being searched in PubMed. In the context of cDNA microarray studies, this may be used for the annotation of gene lists from clusters of genes that are expressed coordinately. An associated PubMatrix public archive provides previous searches using common useful lists of keyword terms. Conclusions In this way, lists of terms, such as gene names, or functional assignments can be assigned genetic, biological, or clinical relevance in a rapid flexible systematic fashion. http://pubmatrix.grc.nia.nih.gov/

  9. Comparison of the retrieval of EBSCO- MEDLINE and PubMed%EBSCO-MEDLINE与PubMed检索之比较

    Institute of Scientific and Technical Information of China (English)

    张红梅; 王桂清

    2006-01-01

    通过对EBSCO-MEDLINE与PubMed进行限定子集、检索界面、检索过程以及多个检索实例的比较,分析其异同以及各自的特点,为用户进行正确选择及有效检索提供参考.

  10. Crystal structure of 7,7-dimethyl-6-methyl-idenetri-cyclo-[6.2.1.0(1,5)]undecane-2-carb-oxy-lic acid.

    Science.gov (United States)

    Beghidja, Noureddine; Benayache, Samir; Benayache, Fadila; Knight, David W; Kariuki, Benson M

    2015-02-01

    In the title compound, C15H22O2, both five-membered rings display an envelope conformation whereas the six-membered ring displays a chair conformation. In the crystal, pairs of O-H⋯O hydrogen bonds between carb-oxy-lic groups link mol-ecules, related by a twofold rotation axis, into supra-molecular dimers.

  11. [Analysis of the meiotic recombination frequency in transgenic tomato hybrids expressing recA and NLS-recA-licBM3 genes].

    Science.gov (United States)

    Komakhin, R A; Komakhina, V V; Miliukova, N A; Zhuchenko, A A

    2012-01-01

    To study and induce meiotic recombination in plants, we generated and analyzed transgenic tomato hybrids F1-RecA and F1-NLS-recA-LicBM3 expressing, respectively, the recA gene of Escherichia coli and the NLS-recA-licBM3 gene. It was found that the recA and NLS-recA-licBM3 genes are inherited through the maternal and paternal lineages, they have no selective influence on the pollen and are contained in tomato F1-RecA and F1-NLS-RecA-LicBM3 hybrids outside the second chromosome in the hemizygous state. The comparative analysis of the meiotic recombination frequency (rf) in the progenies of the transgenic and nontransgenic hybrids showed that only the expression of the recA gene of E. coli in cells of the F1-RecA plants produced a 1.2-1.5-fold increase in the frequency of recombination between some linked marker genes of the second chromosome of tomato.

  12. 40 CFR 721.5375 - Ni-tro-thio-phene-car-boxy-lic acid, ethyl es-ter, bis-[[[[(sub-sti-tut-ed)] amino]-alkyl-phenyl...

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Ni-tro-thio-phene-car-boxy-lic acid... CHEMICAL SUBSTANCES Significant New Uses for Specific Chemical Substances § 721.5375 Ni-tro-thio-phene-car... and significant new uses subject to reporting. (1) The chemical substance ni-tro-thio-phene-car-boxy...

  13. Capital simbòlic, dominació i legitimitat. Les arrels weberianes de la sociologia de Pierre Bourdieu

    OpenAIRE

    José FERNÁNDEZ FERNÁNDEZ

    2013-01-01

    La noció de capital simbòlic és un dels conceptes més complexos construïts per Pierre Bourdieu. Aquest article ofereix una anàlisi crítica del seu origen, significat i funcions. S'hi explora l'ús que va fer d'aquest concepte en les seves investigacions sobre les diferents formes de dominació, els camps de producció simbòlica, el camp burocràtic, les estratègies simbòliques de les classes dominants i les lluites simbòliques per l'hegemonia en la societat global. Encara que mostra rellevants se...

  14. AliBaba: PubMed as a graph.

    Science.gov (United States)

    Plake, Conrad; Schiemann, Torsten; Pankalla, Marcus; Hakenberg, Jörg; Leser, Ulf

    2006-10-01

    The biomedical literature contains a wealth of information on associations between many different types of objects, such as protein-protein interactions, gene-disease associations and subcellular locations of proteins. When searching such information using conventional search engines, e.g. PubMed, users see the data only one-abstract at a time and 'hidden' in natural language text. AliBaba is an interactive tool for graphical summarization of search results. It parses the set of abstracts that fit a PubMed query and presents extracted information on biomedical objects and their relationships as a graphical network. AliBaba extracts associations between cells, diseases, drugs, proteins, species and tissues. Several filter options allow for a more focused search. Thus, researchers can grasp complex networks described in various articles at a glance. http://alibaba.informatik.hu-berlin.de/

  15. New ATPase regulators-p97 goes to the PUB

    DEFF Research Database (Denmark)

    Madsen, Louise; Seeger, Michael; Semple, Colin A;

    2009-01-01

    The conserved eukaryotic AAA-type ATPase complex, known as p97 or VCP in mammals and Cdc48 in yeast, is involved in a number of cellular pathways, including fusion of homotypic membranes, protein degradation, and activation of membrane-bound transcription factors. Most likely, p97 is directed to ...... of the currently known PUB-domain proteins and other p97-interacting proteins....

  16. Contribution of the Global Soil Wetness Project 2 for PUB

    Science.gov (United States)

    Oki, T.; Dirmeyer, P. A.

    2003-04-01

    The Second Global Soil Wetness Project (GSWP-2) is the principal element of the large-scale uncoupled land surface modeling action in the Global Land-Atmosphere System Study (GLASS; Polcher et al. 2000) and a major element of the International Satellite Land-Surface Climatology Project (ISLSCP), both contributing projects of GEWEX. The overarching goal of GSWP is to produce as a community effort the best model estimates of the global land-surface water and energy cycles. This will entail an evaluation of the uncertainties linked to the land surface schemes (LSSs), their parameters, the forcing variables which drive them, and the spatial and temporal scales to run the numerical simulations. The original pilot phase of GSWP covered the two-year period of the ISLSCP initiative I data set (1987-1988), and proved the utility of model comparison and sensitivity studies of the land surface at the global scale (Dirmeyer et al. 1999). GSWP-2 will take advantage of the 10-year (1986-1995) ISLSCP Initiative II data set (http://islscp2.sesda.com/) and LSS simulations will be conducted at a spatial resolution of 1o, sans Antarctica. LSSs calculate runoff and it can be compared with river discharge with applying runoff routing models. Therefore GSWP can be considered as PUB on global scales. Regional scales should be more focused in PUB as hydrological science, nevertheless studies on global scale is also relevant since there are many places in the world where global datasets of precipitation, landuse, soil types, etc., are the only sources available for simulation and prediction of river runoff. Numerical experiments under GSWP2 is well designed to examine the uncertainties associated with the global offline simulations, and the outcomes should contribute for PUB studies very much. GSWP2 in PUB is also expected to identify to what extent of temporal and spatial resolution predicting river runoff can be estimated from global approach.

  17. BMN上的Medline与PubMed的比较分析

    Institute of Scientific and Technical Information of China (English)

    周瑛

    2003-01-01

    通过实例研究,比较了PubMed与BMN上的Medline数据库的不同特点在使用上的差异,分析了这些差异对检索结果的影响。提出熟悉的掌握不同站的Medline的异同点。将有利于更好地开展医学信息服务。

  18. Crystal structures of two nickel compounds comprising neutral Ni(II) hydrazone complexes and di-carb-oxy-lic acids.

    Science.gov (United States)

    Nakanishi, Takumi; Sato, Osamu

    2017-02-01

    Two isostructural Ni(II) compounds, bis-{N-[1-(pyridin-2-yl-κN)eth-ylidene]pyridine-4-carbohydrazonato-κ(2)N',O}nickel(II)-2,5-di-chloro-terephthalic acid (1/1), [Ni(C13H11N4O)2](C8H4Cl2O4), and bis-{N-[1-(pyridin-2-yl-κN)eth-ylidene]pyridine-4-carbohydrazonato-κ(2)N',O}nickel(II)-2,5-di-bromo-terephthalic acid (1/1), [Ni(C13H11N4O)2](C8H4Br2O4), were synthesized and their crystal structures determined. The pair of N,N',O-tridentate N-[1-(pyridin-2-yl-κN)eth-yl]pyridine-4-carbohydrazonate L ligands result in a cis-NiO2N4 octa-hedral coordination sphere for the metal ions. The asymmetric units consist of two half-mol-ecules of the di-carb-oxy-lic acids, which are completed by crystallographic inversion symmetry. In the respective crystals, the 2,5-di-chloro-terephthalic acid (H2Cl2TPA, 1-Cl) mol-ecules form zigzag hydrogen-bonded chains with the [Ni(L)2] mol-ecules, with the hydrogen-bond distances in 1-Br slightly longer than those in 1-Cl. The packing is consolidated by aromatic π-π stacking between the di-carb-oxy-lic acid mol-ecules and terminal pyridine rings in [Ni(L)2] and short halogen-halogen inter-actions are also observed. The qualitative prediction of the H-atom position from the C-N-C angles of the terminal pyridine rings in L and the C-O distances in the carboxyl groups show that 1-Cl and 1-Br are co-crystals rather than salts.

  19. PUB22 and PUB23 U-BOX E3 ligases directly ubiquitinate RPN6, a 26S proteasome lid subunit, for subsequent degradation in Arabidopsis thaliana

    DEFF Research Database (Denmark)

    Cho, Seok Keun; Bae, Hansol; Ryu, Moonyoung

    2015-01-01

    and PUB23, two U-box E3 ligase homologs, tether ubiquitins to 19S proteasome regulatory particle (RP) subunit RPN6, leading to its degradation. RPN6 was identified as an interacting substrate of PUB22 by yeast two-hybrid screening, and in vitro pull-down assay confirmed that RPN6 interacts not only......, these results solidify a notion that PUB22 and PUB23 can alter the activity of 26S proteasome in response to drought stress....

  20. Searches Comparing between Google Scholar and PubMed%Google Scholar与PubMed搜索比较

    Institute of Scientific and Technical Information of China (English)

    薛俊峰; 张梅; 牛晓芳

    2008-01-01

    Google Scholar是综合性的搜索引擎,PubMed是专业性的检索数据库,两个系统的共同点是都能搜索学术文章,但由于两者拥有不相同的搜索数据及搜索方式的极不相同,返回的结果往往不同.通过对GoogleScholar和PubMed做各种不同的搜索试验,对搜索结果进行比较和对比,得出两个系统之间的不同之处,发现造成这些不同的原因,以更清晰地了解GoogleScholar和PubMed各自的搜索能力.

  1. How to improve your PubMed/MEDLINE searches: 2. display settings, complex search queries and topic searching.

    Science.gov (United States)

    Fatehi, Farhad; Gray, Leonard C; Wootton, Richard

    2014-01-01

    The way that PubMed results are displayed can be changed using the Display Settings drop-down menu in the result screen. There are three groups of options: Format, Items per page and Sort by, which allow a good deal of control. The results from several searches can be temporarily stored on the Clipboard. Records of interest can be selected on the results page using check boxes and can then be combined, for example to form a reference list. The Related Citations is a valuable feature of PubMed that can provide a set of similar articles when you have identified a record of interest among the results. You can easily search for RCTs or reviews using the appropriate filters or field tags. If you are interested in clinical articles, rather than basic science or health service research, then the Clinical Queries tool on the PubMed home page can be used to retrieve them.

  2. 2-(2-Carb-oxy-eth-yl)-1,3-dioxoisoindoline-5,6-dicarb-oxy-lic acid methanol monosolvate.

    Science.gov (United States)

    Khorasani, Sanaz; Fernandes, Manuel A

    2012-01-01

    In the title compound, C(13)H(9)NO(8)·CH(3)OH, the main mol-ecule possesses three carb-oxy-lic acid groups, which are asymmetrically distributed around the mol-ecule core. This results in hydrogen-bonding motifs ranging from a chain to various rings. The combination of the chain motif together with a carb-oxy-lic dimer R(2) (2)(8) ring motif creates a ribbon of mol-ecules propagating along the c-axis direction. A second ribbon results from the combination of the chain motif together with a methanol solvent mol-ecule and carboxyl-containing R(4) (4)(12) ring motif. These two ribbons combine alternately, forming a hydrogen-bonded layer of mol-ecules parallel to (2[Formula: see text]0).

  3. Medical literature searches: a comparison of PubMed and Google Scholar.

    Science.gov (United States)

    Nourbakhsh, Eva; Nugent, Rebecca; Wang, Helen; Cevik, Cihan; Nugent, Kenneth

    2012-09-01

    Medical literature searches provide critical information for clinicians. However, the best strategy for identifying relevant high-quality literature is unknown. We compared search results using PubMed and Google Scholar on four clinical questions and analysed these results with respect to article relevance and quality. Abstracts from the first 20 citations for each search were classified into three relevance categories. We used the weighted kappa statistic to analyse reviewer agreement and nonparametric rank tests to compare the number of citations for each article and the corresponding journals' impact factors. Reviewers ranked 67.6% of PubMed articles and 80% of Google Scholar articles as at least possibly relevant (P = 0.116) with high agreement (all kappa P-values Google Scholar articles had a higher median number of citations (34 vs. 1.5, P Google Scholar searches often identify different articles. In this study, Google Scholar articles were more likely to be classified as relevant, had higher numbers of citations and were published in higher impact factor journals. The identification of frequently cited articles using Google Scholar for searches probably has value for initial literature searches. © 2012 The authors. Health Information and Libraries Journal © 2012 Health Libraries Group.

  4. Astronomy on Tap: science engagement in the pub

    Science.gov (United States)

    Livermore, Rachael C.; Silverman, Jeffrey Michael

    2015-08-01

    Astronomy on Tap is a series of free lectures by astronomers in the pub, aimed at disseminating the latest research to the public in an informal setting. Started in New York City in 2013, Astronomy on Tap has now expanded to seven cities across North and South America. Organized by local astronomers, each event features talks by astronomers from local institutions or visitors, or others whose professions or hobbies intersect with astronomy, along with games and opportunities for the public to interact with professional astronomers. The largest Astronomy on Tap events are in Austin, Texas, attracting over 150 people each month, which consists of populations outside of the self-selected groups that might be reached by more formal EPO activities. The organisers of Astronomy on Tap in Austin (AoTATX) will discuss the impact of and feedback from all of the locations, and present information on setting up new satellite locations.

  5. PubChem3D: Biologically relevant 3-D similarity

    Directory of Open Access Journals (Sweden)

    Kim Sunghwan

    2011-07-01

    Full Text Available Abstract Background The use of 3-D similarity techniques in the analysis of biological data and virtual screening is pervasive, but what is a biologically meaningful 3-D similarity value? Can one find statistically significant separation between "active/active" and "active/inactive" spaces? These questions are explored using 734,486 biologically tested chemical structures, 1,389 biological assay data sets, and six different 3-D similarity types utilized by PubChem analysis tools. Results The similarity value distributions of 269.7 billion unique conformer pairs from 734,486 biologically tested compounds (all-against-all from PubChem were utilized to help work towards an answer to the question: what is a biologically meaningful 3-D similarity score? The average and standard deviation for the six similarity measures STST-opt, CTST-opt, ComboTST-opt, STCT-opt, CTCT-opt, and ComboTCT-opt were 0.54 ± 0.10, 0.07 ± 0.05, 0.62 ± 0.13, 0.41 ± 0.11, 0.18 ± 0.06, and 0.59 ± 0.14, respectively. Considering that this random distribution of biologically tested compounds was constructed using a single theoretical conformer per compound (the "default" conformer provided by PubChem, further study may be necessary using multiple diverse conformers per compound; however, given the breadth of the compound set, the single conformer per compound results may still apply to the case of multi-conformer per compound 3-D similarity value distributions. As such, this work is a critical step, covering a very wide corpus of chemical structures and biological assays, creating a statistical framework to build upon. The second part of this study explored the question of whether it was possible to realize a statistically meaningful 3-D similarity value separation between reputed biological assay "inactives" and "actives". Using the terminology of noninactive-noninactive (NN pairs and the noninactive-inactive (NI pairs to represent comparison of the "active/active" and

  6. Benzene-1,3,5-tri-carb-oxy-lic acid-pyridinium-2-olate (1/3).

    Science.gov (United States)

    Campos-Gaxiola, José J; Zamora Falcon, Felipe; Corral Higuera, Ramón; Höpfl, Herbert; Cruz-Enríquez, Adriana

    2014-04-01

    The asymmetric unit of the title compound, C9H6O6·3C5H5NO, contains one benzene-1,3,5-tri-carb-oxy-lic acid mol-ecule (BTA) and three pyridin-2-ol mol-ecules each present in the zwitterion form. In the crystal, these entities are linked through O-H⋯O(-) and N(+)-H⋯O(-) hydrogen bonds, forming sheets parallel to (10-1). These layers contain macrocyclic rings of composition [BTA]2[pyol]6 and with graph-set notation R (6) 8(44), which are stacked along c through π-π inter-actions [inter-centroid distances = 3.536 (2)-3.948 (3) Å]. They are inter-connected by N(+)-H⋯O(-) hydrogen-bonded chains of pyridin-2-ol mol-ecules running parallel to c, forming a three-dimensional network. There are also C-H⋯O hydrogen bonds present which reinforce the three-dimensional structure.

  7. ONER: Tool for Organization Named Entity Recognition from Affiliation Strings in PubMed Abstracts

    CERN Document Server

    Jonnalagadda, Siddhartha; Gonzalez, Graciela

    2010-01-01

    Automatically extracting organization names from the affiliation sentences of articles related to biomedicine is of great interest to the pharmaceutical marketing industry, health care funding agencies and public health officials. It will also be useful for other scientists in normalizing author names, automatically creating citations, indexing articles and identifying potential resources or collaborators. Today there are more than 18 million articles related to biomedical research indexed in PubMed, and information derived from them could be used effectively to save the great amount of time and resources spent by government agencies in understanding the scientific landscape, including key opinion leaders and centers of excellence. Our process for extracting organization names involves multi-layered rule matching with multiple dictionaries. The system achieves 99.6% f-measure in extracting organization names.

  8. The development of PubMed search strategies for patient preferences for treatment outcomes

    Directory of Open Access Journals (Sweden)

    Ralph van Hoorn

    2016-07-01

    Full Text Available Abstract Background The importance of respecting patients’ preferences when making treatment decisions is increasingly recognized. Efficiently retrieving papers from the scientific literature reporting on the presence and nature of such preferences can help to achieve this goal. The objective of this study was to create a search filter for PubMed to help retrieve evidence on patient preferences for treatment outcomes. Methods A total of 27 journals were hand-searched for articles on patient preferences for treatment outcomes published in 2011. Selected articles served as a reference set. To develop optimal search strategies to retrieve this set, all articles in the reference set were randomly split into a development and a validation set. MeSH-terms and keywords retrieved using PubReMiner were tested individually and as combinations in PubMed and evaluated for retrieval performance (e.g. sensitivity (Se and specificity (Sp. Results Of 8238 articles, 22 were considered to report empirical evidence on patient preferences for specific treatment outcomes. The best search filters reached Se of 100 % [95 % CI 100-100] with Sp of 95 % [94–95 %] and Sp of 97 % [97–98 %] with 75 % Se [74–76 %]. In the validation set these queries reached values of Se of 90 % [89–91 %] with Sp 94 % [93–95 %] and Se of 80 % [79–81 %] with Sp of 97 % [96–96 %], respectively. Conclusions Narrow and broad search queries were developed which can help in retrieving literature on patient preferences for treatment outcomes. Identifying such evidence may in turn enhance the incorporation of patient preferences in clinical decision making and health technology assessment.

  9. PubMed - Medline. Exportació de registres a RefWorks. Maig 2012

    OpenAIRE

    Universitat de Barcelona. CRAI

    2012-01-01

    També podeu consultar altres tutorials sobre el PubMed: 1. PubMed Medline: Accés, http://hdl.handle.net/2445/15122; 2. PubMed Medline: Cerca bàsica, http://hdl.handle.net/2445/15123; 3. PubMed Medline: Elements de cerca i límits, http://hdl.handle.net/2445/15124; 4. PubMed Medline: Matèries MeSH, http://hdl.handle.net/2445/15125; 5. PubMed Medline: Cerca avançada, http://hdl.handle.net/2445/15126; 6. PubMed Medline: Exemple de cerca avançada, http://hdl.handle.net/2445/15127; 7. PubMed Medli...

  10. 48 CFR 33.205 - Relationship of the Act to Pub. L. 85-804.

    Science.gov (United States)

    2010-10-01

    ... Pub. L. 85-804. 33.205 Section 33.205 Federal Acquisition Regulations System FEDERAL ACQUISITION... Relationship of the Act to Pub. L. 85-804. (a) Requests for relief under Pub. L. 85-804 (50 U.S.C. 1431-1435... available only under Pub. L. 85-804; i.e., legal entitlement to rescission or reformation for mutual mistake...

  11. The Arabidopsis paralogs, PUB46 and PUB48, encoding U-box E3 ubiquitin ligases, are essential for plant response to drought stress.

    Science.gov (United States)

    Adler, Guy; Konrad, Zvia; Zamir, Lyad; Mishra, Amit Kumar; Raveh, Dina; Bar-Zvi, Dudy

    2017-01-11

    Plants respond to abiotic stress on physiological, biochemical and molecular levels. This includes a global change in their cellular proteome achieved by changes in the pattern of their protein synthesis and degradation. The ubiquitin-proteasome system (UPS) is a key player in protein degradation in eukaryotes. Proteins are marked for degradation by the proteasome by coupling short chains of ubiquitin polypeptides in a three-step pathway. The last and regulatory stage is catalyzed by a member of a large family of substrate-specific ubiquitin ligases. We have identified AtPUB46 and AtPUB48-two paralogous genes that encode ubiquitin ligases (E3s)-to have a role in the plant environmental response. The AtPUB46, -47, and -48 appear as tandem gene copies on chromosome 5, and we present a phylogenetic analysis that traces their evolution from an ancestral PUB-ARM gene. Single homozygous T-DNA insertion mutants of AtPUB46 and AtPUB48 displayed hypersensitivity to water stress; this was not observed for similar mutants of AtPUB47. Although the three genes show a similar spatial expression pattern, the steady state levels of their transcripts are differentially affected by abiotic stresses and plant hormones. AtPUB46 and AtPUB48 encode plant U-Box E3s and are involved in the response to water stress. Our data suggest that despite encoding highly homologous proteins, AtPUB46 and AtPUB48 biological activity does not fully overlap.

  12. Utilization of the PICO framework to improve searching PubMed for clinical questions

    Directory of Open Access Journals (Sweden)

    Keitz Sheri

    2007-06-01

    Full Text Available Abstract Background Supporting 21st century health care and the practice of evidence-based medicine (EBM requires ubiquitous access to clinical information and to knowledge-based resources to answer clinical questions. Many questions go unanswered, however, due to lack of skills in formulating questions, crafting effective search strategies, and accessing databases to identify best levels of evidence. Methods This randomized trial was designed as a pilot study to measure the relevancy of search results using three different interfaces for the PubMed search system. Two of the search interfaces utilized a specific framework called PICO, which was designed to focus clinical questions and to prompt for publication type or type of question asked. The third interface was the standard PubMed interface readily available on the Web. Study subjects were recruited from interns and residents on an inpatient general medicine rotation at an academic medical center in the US. Thirty-one subjects were randomized to one of the three interfaces, given 3 clinical questions, and asked to search PubMed for a set of relevant articles that would provide an answer for each question. The success of the search results was determined by a precision score, which compared the number of relevant or gold standard articles retrieved in a result set to the total number of articles retrieved in that set. Results Participants using the PICO templates (Protocol A or Protocol B had higher precision scores for each question than the participants who used Protocol C, the standard PubMed Web interface. (Question 1: A = 35%, B = 28%, C = 20%; Question 2: A = 5%, B = 6%, C = 4%; Question 3: A = 1%, B = 0%, C = 0% 95% confidence intervals were calculated for the precision for each question using a lower boundary of zero. However, the 95% confidence limits were overlapping, suggesting no statistical difference between the groups. Conclusion Due to the small number of searches for each arm

  13. 38 CFR 12.20 - Posting of notice provisions of Pub. L. 382.

    Science.gov (United States)

    2010-07-01

    ... provisions of Pub. L. 382. 12.20 Section 12.20 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS DISPOSITION OF VETERAN'S PERSONAL FUNDS AND EFFECTS Under Pub. L. 382, 77th Congress, December 26, 1941, Amending the Act of June 25, 1910 (24 U.s.c. 136) § 12.20 Posting of notice provisions of Pub. L...

  14. 25 CFR 32.5 - Evaluation of implementation of Pub. L. 95-561.

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Evaluation of implementation of Pub. L. 95-561. 32.5... POLICIES § 32.5 Evaluation of implementation of Pub. L. 95-561. The Director, Office Indian Education... with title XI of the Education Amendments of 1978 (Pub. L. 95-561), and in the January 1, 1981...

  15. Structural adjustment and public spending on health: evidence from IMF programs in low-income countries.

    Science.gov (United States)

    Kentikelenis, Alexander E; Stubbs, Thomas H; King, Lawrence P

    2015-02-01

    The relationship between health policy in low-income countries (LICs) and structural adjustment programs devised by the International Monetary Fund (IMF) has been the subject of intense controversy over past decades. While the influence of the IMF on health policy can operate through various pathways, one main link is via public spending on health. The IMF has claimed that its programs enhance government spending for health, and that a number of innovations have been introduced to enable borrowing countries to protect health spending from broader austerity measures. Critics have pointed to adverse effects of Fund programs on health spending or to systematic underfunding that does not allow LICs to address health needs. We examine the effects of Fund programs on government expenditures on health in low-income countries using data for the period 1985-2009. We find that Fund programs are associated with higher health expenditures only in Sub-Saharan African LICs, which historically spent less than any other region. This relationship turns negative in LICs in other regions. We outline the implications of these findings for health policy in a development context. Copyright © 2014 Elsevier Ltd. All rights reserved.

  16. Combining PubMed knowledge and EHR data to develop a weighted bayesian network for pancreatic cancer prediction.

    Science.gov (United States)

    Zhao, Di; Weng, Chunhua

    2011-10-01

    In this paper, we propose a novel method that combines PubMed knowledge and Electronic Health Records to develop a weighted Bayesian Network Inference (BNI) model for pancreatic cancer prediction. We selected 20 common risk factors associated with pancreatic cancer and used PubMed knowledge to weigh the risk factors. A keyword-based algorithm was developed to extract and classify PubMed abstracts into three categories that represented positive, negative, or neutral associations between each risk factor and pancreatic cancer. Then we designed a weighted BNI model by adding the normalized weights into a conventional BNI model. We used this model to extract the EHR values for patients with or without pancreatic cancer, which then enabled us to calculate the prior probabilities for the 20 risk factors in the BNI. The software iDiagnosis was designed to use this weighted BNI model for predicting pancreatic cancer. In an evaluation using a case-control dataset, the weighted BNI model significantly outperformed the conventional BNI and two other classifiers (k-Nearest Neighbor and Support Vector Machine). We conclude that the weighted BNI using PubMed knowledge and EHR data shows remarkable accuracy improvement over existing representative methods for pancreatic cancer prediction.

  17. Global Health Innovation Technology Models

    Directory of Open Access Journals (Sweden)

    Kimberly Harding

    2016-04-01

    Full Text Available Chronic technology and business process disparities between High Income, Low Middle Income and Low Income (HIC, LMIC, LIC research collaborators directly prevent the growth of sustainable Global Health innovation for infectious and rare diseases. There is a need for an Open Source-Open Science Architecture Framework to bridge this divide. We are proposing such a framework for consideration by the Global Health community, by utilizing a hybrid approach of integrating agnostic Open Source technology and healthcare interoperability standards and Total Quality Management principles. We will validate this architecture framework through our programme called Project Orchid. Project Orchid is a conceptual Clinical Intelligence Exchange and Virtual Innovation platform utilizing this approach to support clinical innovation efforts for multi-national collaboration that can be locally sustainable for LIC and LMIC research cohorts. The goal is to enable LIC and LMIC research organizations to accelerate their clinical trial process maturity in the field of drug discovery, population health innovation initiatives and public domain knowledge networks. When sponsored, this concept will be tested by 12 confirmed clinical research and public health organizations in six countries. The potential impact of this platform is reduced drug discovery and public health innovation lag time and improved clinical trial interventions, due to reliable clinical intelligence and bio-surveillance across all phases of the clinical innovation process.

  18. Global Health Innovation Technology Models

    Directory of Open Access Journals (Sweden)

    Kimberly Harding

    2016-04-01

    Full Text Available Chronic technology and business process disparities between High Income, Low Middle Income and Low Income (HIC, LMIC, LIC research collaborators directly prevent the growth of sustainable Global Health innova‐ tion for infectious and rare diseases. There is a need for an Open Source-Open Science Architecture Framework to bridge this divide. We are proposing such a framework for consideration by the Global Health community, by utiliz‐ ing a hybrid approach of integrating agnostic Open Source technology and healthcare interoperability standards and Total Quality Management principles. We will validate this architecture framework through our programme called Project Orchid. Project Orchid is a conceptual Clinical Intelligence Exchange and Virtual Innovation platform utilizing this approach to support clinical innovation efforts for multi-national collaboration that can be locally sustainable for LIC and LMIC research cohorts. The goal is to enable LIC and LMIC research organizations to acceler‐ ate their clinical trial process maturity in the field of drug discovery, population health innovation initiatives and public domain knowledge networks. When sponsored, this concept will be tested by 12 confirmed clinical research and public health organizations in six countries. The potential impact of this platform is reduced drug discovery and public health innovation lag time and improved clinical trial interventions, due to reliable clinical intelligence and bio-surveillance across all phases of the clinical innovation process.

  19. PubMed与 Embase.com 检索效果对比分析%Comparative analysis of retrieval results from PubMed and Embase.com

    Institute of Scientific and Technical Information of China (English)

    孙艳

    2014-01-01

    目的:对比分析Embase .com和PubMed的检索结果,为科研人员推荐最适合的检索工具和提高检索效率。方法:选取8个不同学科的检索词,在PubMed和Embase.com中分别采用主题词检索和带有自动转换功能的基本检索两种途径检索。结果:8个检索词在检索中出现6种不同情况。结论:通过主题词检索,总体来说Embase.com检全率要高于PubMed;带有自动转换功能的基本检索,两个数据库都会出现错误转换,但从转换的原理上看,PubMed的查准率更高。%Objective To recommend the appropriate retrieval tools for scientific researchers and improve their re-trieval efficiency by comparatively analyzing the retrieval results from PubMed and Embase .com.Methods Eight retrieval terms from different subjects were used to retrieve PubMed and Embase .com by subject headings and basic retrieval methods than can automatically transfer their function .Results Six different results were retrieved from PubMed and Embase.com with 8 retrieval terms.Conclusion The recall ratio is higher in Embase.com than in PubMed when they are retrieved by subject headings while the accuracy ratio is higher in PubMed than in Embase . com when they are retrieved by basic retrieval methods than can automatically transfer their function although error transformation occurs in both PubMed and Embase.com.

  20. PubMed Medline 1: Accés. Gener 2011

    OpenAIRE

    Universitat de Barcelona. CRAI

    2011-01-01

    També podeu consultar altres tutorials sobre el PubMed: 2. PubMed Medline: Cerca bàsica, http://hdl.handle.net/2445/15123; 3. PubMed Medline: Elements de cerca i límits, http://hdl.handle.net/2445/15124; 4. PubMed Medline: Matèries MeSH, http://hdl.handle.net/2445/15125; 5. PubMed Medline: Cerca avançada, http://hdl.handle.net/2445/15126; 6. PubMed Medline: Exemple de cerca avançada, http://hdl.handle.net/2445/15127; 7. PubMed Medline: Gestionar els resultats, http://hdl.handle.net/2445/1512...

  1. PubMed Medline 1: Accés. Gener 2011

    OpenAIRE

    Universitat de Barcelona. CRAI

    2011-01-01

    També podeu consultar altres tutorials sobre el PubMed: 2. PubMed Medline: Cerca bàsica, http://hdl.handle.net/2445/15123; 3. PubMed Medline: Elements de cerca i límits, http://hdl.handle.net/2445/15124; 4. PubMed Medline: Matèries MeSH, http://hdl.handle.net/2445/15125; 5. PubMed Medline: Cerca avançada, http://hdl.handle.net/2445/15126; 6. PubMed Medline: Exemple de cerca avançada, http://hdl.handle.net/2445/15127; 7. PubMed Medline: Gestionar els resultats, http://hdl.handle.net/2445/1512...

  2. Utilization of bar and izakaya-pub establishments among middle-aged and elderly Japanese men to mitigate stress

    Directory of Open Access Journals (Sweden)

    Ohnishi Mayumi

    2012-06-01

    Full Text Available Abstract Japanese suicide rate is one of the highest among industrialized nations, especially following the economic crisis of the 1990s, with more than 30000 suicides every year since 1998. Previous studies have pointed out to relationships between overwork and/or job stress, and death and other health risks, and suggested several possible avenues for releasing stress and emotional burden, including suicidal ideation, through talking with intimate friends, family, and specialists, such as counselors and physicians. The present study was performed to explore the potential role of owners and managers of bars and izakaya-pub establishments in mitigating stress of middle-aged and elderly Japanese men by having informal conversations with them. A self-administered questionnaire was posted to all bars and izakaya-pubs registered in Ohmura-city, Nagasaki prefecture, in December 2009. Among 260 bars and izakaya-pubs, a total of 103 owners and managers completed the questionnaire. More than half of the respondents experienced engaging in conversations with their customers regarding customers’ various personal and private issues. The most frequently talked about problem was that regarding work (56.3%. Regardless of sex and age of the respondents, those with longer working experience in bar and izakaya-pub establishments were more likely to have had customers confiding in them financial problems including debts/loans (adjusted odds ratio: 5.48, p = 0.033. Owners and managers of bars and izakaya-pubs may be in a position to act as “listeners”, to whom middle-aged and elderly men can talk about their personal problems casually and without having to worry about conflict of interests, and direct those in need to professional counseling.

  3. Utilization of bar and izakaya-pub establishments among middle-aged and elderly Japanese men to mitigate stress.

    Science.gov (United States)

    Ohnishi, Mayumi; Nakao, Rieko; Kawasaki, Ryokko; Nitta, Akiko; Hamada, Yukari; Nakane, Hideyuki

    2012-06-18

    Japanese suicide rate is one of the highest among industrialized nations, especially following the economic crisis of the 1990s, with more than 30000 suicides every year since 1998. Previous studies have pointed out to relationships between overwork and/or job stress, and death and other health risks, and suggested several possible avenues for releasing stress and emotional burden, including suicidal ideation, through talking with intimate friends, family, and specialists, such as counselors and physicians. The present study was performed to explore the potential role of owners and managers of bars and izakaya-pub establishments in mitigating stress of middle-aged and elderly Japanese men by having informal conversations with them. A self-administered questionnaire was posted to all bars and izakaya-pubs registered in Ohmura-city, Nagasaki prefecture, in December 2009. Among 260 bars and izakaya-pubs, a total of 103 owners and managers completed the questionnaire. More than half of the respondents experienced engaging in conversations with their customers regarding customers' various personal and private issues. The most frequently talked about problem was that regarding work (56.3%). Regardless of sex and age of the respondents, those with longer working experience in bar and izakaya-pub establishments were more likely to have had customers confiding in them financial problems including debts/loans (adjusted odds ratio: 5.48, p = 0.033). Owners and managers of bars and izakaya-pubs may be in a position to act as "listeners", to whom middle-aged and elderly men can talk about their personal problems casually and without having to worry about conflict of interests, and direct those in need to professional counseling.

  4. GAPscreener: An automatic tool for screening human genetic association literature in PubMed using the support vector machine technique

    Directory of Open Access Journals (Sweden)

    Khoury Muin J

    2008-04-01

    Full Text Available Abstract Background Synthesis of data from published human genetic association studies is a critical step in the translation of human genome discoveries into health applications. Although genetic association studies account for a substantial proportion of the abstracts in PubMed, identifying them with standard queries is not always accurate or efficient. Further automating the literature-screening process can reduce the burden of a labor-intensive and time-consuming traditional literature search. The Support Vector Machine (SVM, a well-established machine learning technique, has been successful in classifying text, including biomedical literature. The GAPscreener, a free SVM-based software tool, can be used to assist in screening PubMed abstracts for human genetic association studies. Results The data source for this research was the HuGE Navigator, formerly known as the HuGE Pub Lit database. Weighted SVM feature selection based on a keyword list obtained by the two-way z score method demonstrated the best screening performance, achieving 97.5% recall, 98.3% specificity and 31.9% precision in performance testing. Compared with the traditional screening process based on a complex PubMed query, the SVM tool reduced by about 90% the number of abstracts requiring individual review by the database curator. The tool also ascertained 47 articles that were missed by the traditional literature screening process during the 4-week test period. We examined the literature on genetic associations with preterm birth as an example. Compared with the traditional, manual process, the GAPscreener both reduced effort and improved accuracy. Conclusion GAPscreener is the first free SVM-based application available for screening the human genetic association literature in PubMed with high recall and specificity. The user-friendly graphical user interface makes this a practical, stand-alone application. The software can be downloaded at no charge.

  5. Mineralogical and numerical approaches to establish the pre-eruptive conditions of the mafic Licán Ignimbrite, Villarrica Volcano (Chilean Southern Andes)

    Science.gov (United States)

    Lohmar, Silke; Parada, Miguel; Gutiérrez, Francisco; Robin, Claude; Gerbe, Marie Christine

    2012-08-01

    The Licán Ignimbrite represents a large explosive basaltic andesite event in the eruptive history of the Villarrica Volcano, an active stratovolcano of the Southern Andean Volcanic Zone. A mineralogical study of this ignimbrite indicates important disequilibrium features. Resoption textures were observed around Ca-rich (An74-92; Group 1) and more sodic (An35-44; Group 2) plagioclase phenocryst cores. Rims on these phenocrysts as well as microlites grew with an intermediate composition (An47-63; Group 3). Low- and high-Mg clinopyroxene and orthopyroxene phenocrysts were also identified; most of them showing reverse Mg zoning. Based on these mineralogical data and thermodynamic modeling, an increase of about 200 °C in temperature (from ~ 900-1000° to ~ 1100-1150 °C), a decompression of ~ 400 bar (equivalent to ~ 1.5 km) and a decrease in H2O content in the melt of ~ 1.6 wt.% are identified during crystallization. Addition of hot magma from below would have caused heating of the reservoir with the consecutive ascent of magma pulses, H2O exsolution and convective mixing (compositional and/or thermal mixing). A numerical model using the Finite Element Method was developed to assess the response of the Licán Ignimbrite reservoir upon conductive heating by 200 °C by mafic underplating; this model indicates a rapid (tens of years) temperature homogenization of this system, with ascending magma plumes with velocities as high as 6 m/h. Because the Licán Ignimbrite erupted at the end of the Pleistocene glaciation, glacial unloading could have also contributed to depressurization of the reservoir.

  6. Pubmed Assistant-a Helper Toolkit for Pubmed Searching%PubMed助手——提高PubMed检索效果的好帮手

    Institute of Scientific and Technical Information of China (English)

    关中玉; 谢奇; 李立立; 高桐

    2007-01-01

    介绍一种PubMed辅助软件-PubMed助手,在具备PubMed已有的检索功能基础上,它还增加可视化检索策略编辑器,可以非常容易的编辑复杂的布尔逻辑检索策略,甚至可以根据已有几篇相关文献,自动制定高级检索策略.PubMed助手还提供专门的浏览器,可以直接在主界面中浏览所有检索结果的题录信息,而不用每次都打开新页面.可以突出显示关键字,输出检索结果,点击进入google或Google学术搜索等.

  7. Research on Evidence-based Traditional Chinese Medicine Literature Retrieval in PubMed%PubMed的循证中医药文献检索研究

    Institute of Scientific and Technical Information of China (English)

    周满英

    2016-01-01

    文章介绍了利用PubMed数据库检索循证中医药证据时的检索技巧和四种有效而快捷的检索方式,并结合实例分析各方式的检索特点,以期为循证中医药研究人员检索PubMed时提供参考。%This paper introduces the search tips and foureffective andefficientways to usePubMedto retrieveevidenceof evidence -based traditionalChinese medicine, use retrieval case to analyzethe characteristic ofeachway,in order toprovide references to evidence-basedtraditional Chinesemedicineresearchersretrieve inPubMed.

  8. 如何利用PubMed检索医学文献%Method on How to Retrieve Medical Literature from PubMed

    Institute of Scientific and Technical Information of China (English)

    刁继红; 甄连花

    2009-01-01

    目的:为便于医药工作者更好地利用PubMed检索外文文献提供参考.方法:结合实例,从检索方法、特殊服务功能、特征栏使用、检索结果的存盘与打印等方面对PubMed进行详细介绍.结果与结论:PubMed是世界公认的最重要、最具权威性且使用率最高的生物医学文献数据库之一,其内客涉及生物医学的各个领域.掌握PubMed的检索方法和技巧将有助于广大医务工作者快速、准确地检索外文文献.

  9. The Application of Individual Service Functions of PubMed System%PubMed系统个性化服务功能应用

    Institute of Scientific and Technical Information of China (English)

    宁淑华

    2008-01-01

    美国国家医学图书馆开发的PubMed是我国医学科技人员最常使用的一个生物医学文献检索系统,针对PubMed实际应用中的个性化服务功能予以探索,旨在为读者提供一些有益的帮助.

  10. Materia Socio Medica is Indexed in Pubmed and Archived in PubMed Central.

    Science.gov (United States)

    Masic, Izet

    2013-01-01

    Materia Socio Medica Journal has been accepted for archiving in PubMed Central from 2011. The journal started in 1993 as offi cial journal of Social Medicine Association of B&H. During last 3 years Mat Soc Med has included in almost all femous on-line databases (except WoS). All issues of Mat Soc Med published in 2012 are now visible on PubMed/PubMed Central.

  11. 徐州地区黑大蒜饮料市场推广策略研究%Research on Marketing Strategy of BLack GarLic Drinks in Xuzhou Region

    Institute of Scientific and Technical Information of China (English)

    李亚飞; 袁子桐; 邱珂禹

    2013-01-01

    BLack garLic drinks is the new product deveLoped recentLy by Xuzhou Lvzhiye company. This articLe surveys the cognition to garLic and garLic drinks of consumers in Xuzhou region. Based on the survey, this articLe confirms the target market and provides the reLated marketing strategy.%  黑大蒜饮料是徐州绿之野公司新近研发出来的产品。文章调研了徐州地区消费者对大蒜及大蒜饮料的认知情况,据此确定了大蒜饮料的目标市场,并提出了相关的市场推广策略。

  12. So/lic

    Science.gov (United States)

    Henkel, Paul A.

    1990-11-01

    Current and forecast reductions in the defense budget are being compounded by the fact that certain programs are protected from budget cuts, to some extent, because of their highly classified nature. This fact is particularly true in the airborne reconnaissance field. Survival of unprotected airborne reconnaissance programs, according to a congressional staffer, can be considerably enhanced if they fall under the umbrella of verification/open skies, drug war, or special operations/low intensity conflict (SOLIC) areas of support. An application to the SOUC mission is an F-16 reconnaissance POD attached to the U-27 Cessna Caravan. The Caravan reconnaissance system consists of an infrared line scanning imagery sensor, a steerable forward-looking infrared sensor, and an electro-optic push broom imagery sensor. Also included is an imagery recorder, video management system and imagery data link. The U27 cabin is modified to provide the sensor operator with real time display and control of all sensors with a repeater display for the pilot. The caravan is not limited to the reconnaissance mission. Quick reconfiguration can provide for an airborne command post version, strike version with 50 caliber three-barrel Gatling gun and missiles, hospital medical evacuation, or transport. The aircraft is self sufficient and can operate off of minimally prepared landing strips. It appears that initiatives such as this are a direction that can significantly expand the airborne reconnaissance market, and requires the development of innovative new sensors and support systems.

  13. Information management and complementary alternative medicine: the anatomy of information about CAMs through PubMed.

    Science.gov (United States)

    Corrao, Salvatore; Argano, Christiano; Colomba, Daniela; Ippolito, Calogero; Gargano, Vincenzo; Arcoraci, Vincenzo; Licata, Giuseppe

    2013-10-01

    In recent years, there has been a growing interest about complementary and alternative medicine (CAM), and the use of CAM interventions has become more common among people. For these reasons, health professionals must be able to effectively manage information in this field of knowledge according to an evidence-based point of view. This study assessed the anatomy of the available information about CAMs using PubMed, to give practical instructions to manage information in this field. We also analyzed the anatomy of information according to each alternative medicine branch, narrow and broad search methods, subset filters for indexed-for-Medline and non-indexed citations, and different publication types including randomized controlled trials (RCTs) and meta-analyses. Our results demonstrated that the use of CAMs subset (supplied by PubMed search engine) leads to a great number of citations determining an information overload. Our data reveal that it would be more useful to search for the CAM separately, identifying specific items and study design. Moreover, we found the largest number of randomized clinical trials and meta-analyses related to herbal medicine and acupuncture, neither RCTs nor meta-analyses were available for bach and flower remedies, auriculoacupuncture, iridology, and pranotherapy. For the first time, our study gives a comprehensive view of the anatomy of information regarding CAMs and each branch of them. We suggest a methodological approach to face with searching information about this emerging issue from an evidence-based point of view. Finally, our data pointed out some "grey zones" since neither RCTs nor meta-analyses were available for some CAMs.

  14. Towards an Ontology of ElPub/SciX: A Proposal

    OpenAIRE

    2007-01-01

    A proposal is presented for a standard ontology language defined as ElPub/SciX Ontology, based on the content of a web digital library of conference proceedings. This content, i.e., ElPub/SciX documents, aims to provide access to papers presented at the total editions of the International Conference in Electronic Publishing (ElPub). After completing its 10th years in 2006, ElPub/SciX is now a comprehensive repository with over 400 papers. Previous work has been used as a basis to build up the...

  15. PubMed快速检索功能的实现

    Institute of Scientific and Technical Information of China (English)

    李波

    2009-01-01

    介绍了三部分内容:第一先将PubMed添加到带Goosle工具栏的Firefox浏览器,获得符合IE7要求的URL,然后添加到IE7的搜索工具栏;第二介绍了利用NCBI Search ToolKit工具将PubMed和NCBI添加到IE浏览器的右键;最后介绍了基于Mozilla内核浏览器的PubMed search plugin,它们都可以实现快速检索PubMed数据库的功能.

  16. Crystal structure of a 2:1 co-crystal of meloxicam with acetyl­endi­carb­oxy­lic acid

    Science.gov (United States)

    Tantardini, Christian; Arkhipov, Sergey G.; Cherkashina, Ksenya A.; Kil’met’ev, Alexander S.; Boldyreva, Elena V.

    2016-01-01

    The pharmaceutical 2:1 co-crystal of meloxicam [MXM; systematic name: 4-hy­droxy-2-methyl-N-(5-methyl­thia­zol-2-yl)-2H-1,2-benzo­thia­zine-3-carboxamide 1,1-dioxide] with acetyl­enedi­carb­oxy­lic acid (ACA; systematic name: but-2-ynedioic acid), crystallizes with one MXM mol­ecule and half an ACA mol­ecule in the asymmetric unit, C14H13N3O4S2·0.5C4H2O4. The mid-point of the triple bond of ACA is located on an inversion centre. In the crystal, the two stereoisomers of MXM with respect to the N atom of the sulfonamide group are related by the inversion centre. The carbonyl and hy­droxy groups belonging to the MXM mol­ecule are involved in an intra­molecular O—H⋯O hydrogen bond. The structure-forming motif includes two MXM mol­ecules linked via an ACA conformer through N—H⋯O and O—H⋯N hydrogen bonds, similar to MXM co-crystals with other di­carb­oxy­lic acids. PMID:27980849

  17. Acerca de la gestión de la producción científica en las carreras de Lic. en Kinesiología y Fisiatría en el marco institucional de las universidades nacionales

    OpenAIRE

    Álvarez, Javier; Priotti, Mónica; Diodati, Mariano

    2007-01-01

    El presente trabajo se encuadra en un proyecto de investigación en curso a través del cual nos proponemos indagar sobre el contexto de surgimiento de las carreras de Lic. en Kinesiología y Fisiatría en el marco institucional de las universidades nacionales. La carrera de Lic. en Kinesiología y Fisiatría que se dicta en la ciudad de Rosario desde el año 1998, en convenio con la Universidad Nacional de San Martín y la Fundación del Gran Rosario, tiene como preocupaciones centrales la generac...

  18. PubMed与MEDLINE光盘检索不同之处的特点探讨%What's the difference between PubMed and CD-ROM MEDLINE

    Institute of Scientific and Technical Information of China (English)

    陈国琪

    2004-01-01

    目的:探讨PubMed检索的主要特点以提高文献的查准率.方法:分别举例介绍PubMed数据时限、超级主题词表、查询词自动转换、主题词检索、临床课题查询、Entrez-PubMed、PubMed Central(PMC).结果:PubMed检索,除MEDLINE外,还包括PREMEDLINE和OLDMEDLINE,其最早的文献可追溯到1951年.通过查询词转换和匹配及其临床课题研究范围的灵敏度和专指度的选择,使检出的文献更加切题.PubMed 还通过与全球NCBI搜索引擎Entrez链接,可互查PMC、核酸序列、蛋白质序列、大分子结构、全基因组、生物体分类学、人类孟德尔遗传及MEDLINE数据库等.检出的记录包括文献条目和摘要,链接后可获取出版商网址上的全文及其在PMC中的免费期刊(160种)原文.结论:PubMed为一般的医学工作者检索文献提供的服务比MEDLINE光盘要多.

  19. Mobile app versus Web app: a comparison using 2008-2012 "PubMed for Handhelds" server data.

    Science.gov (United States)

    Fontelo, Paul; Liu, Fang

    2013-01-01

    Recent surveys show that mobile apps are more popular than Web apps. Apple's iTunes Store, now has about 800,000 apps and reported to have about 40 billion downloads. Android apps, although fewer, is available to the most number of smartphones today. About 40,000 apps are medical or health related. We developed a PubMed4Hh mobile app for iPhone/iPad users to search MEDLINE/PubMed with same features as our Web-based search tools, in use since 2002. Five-year (2008-2012) server data for PubMed4Hh and Web app were analyzed. Searches using the mobile app significantly increased compared to the same five-year time period. Month-by-month comparison showed a 3 to 5-fold increase in queries. The six-month total accesses comparison increased 280% from the previous four-year average. A review of 500 randomly selected queries revealed that the majority of queries were clinical questions ((97.8%) and 61% of these queries are searches related to therapy.

  20. 75 FR 39273 - Energy Independence and Security Act (Pub. L. 110-140)

    Science.gov (United States)

    2010-07-08

    ....S. Geological Survey Energy Independence and Security Act (Pub. L. 110-140) AGENCY: U.S. Geological.... SUMMARY: In 2007, the Energy Independence and Security Act (Pub. L. 110-140) directed the United States... 711 of Public Law 110-140. Dated: June 28, 2010. Brenda Pierce, Chief Scientist (acting) and...

  1. Three PubMed skills to support evidence-based dentistry.

    Science.gov (United States)

    Deahl, S Thomas

    2011-02-01

    The National Library of Medicine's PubMed database can powerfully assist dentists in evidence-based practice. Three useful PubMed skills can improve the efficiency of the clinician's search: (1) Use of MeSH terms; (2) Use of Limits; (3) Use of Clinical Queries.

  2. Searching PubMed for molecular epidemiology studies: the case of chromosome aberrations

    DEFF Research Database (Denmark)

    Ugolini, Donatella; Neri, Monica; Knudsen, Lisbeth E

    2006-01-01

    to environmental pollutants. The search, done on the PubMed/MedLine database, was based on a strategy combining descriptors listed in the PubMed Medical Subject Headings (MeSH) Thesaurus and other available tools (free text or phrase search tools). 178 articles were retrieved by searching the period from January 1...

  3. How to improve your PubMed/MEDLINE searches: 1. background and basic searching.

    Science.gov (United States)

    Fatehi, Farhad; Gray, Leonard C; Wootton, Richard

    2013-12-01

    PubMed provides free access via the Internet to more than 23 million records, of which over 19 million are from the MEDLINE database of journal articles. PubMed also provides access to other databases, such as the NCBI Bookshelf. To perform a basic search, you can simply enter the search terms or the concept that you are looking for in the search box. However, taking care to clarify your key concepts may save much time later on, because a non-specific search is likely to produce an overwhelming number of result hits. One way to make your search more specific is to specify which field you want to search using field tags. By default, the results of a search are sorted by the date added to PubMed and displayed in summary format with 20 result hits (records) on each page. In summary format, the title of the article, list of authors, source of information (e.g., journal name followed by date of publication, volume, issue, pages) and the unique PubMed record number called the PubMed identifier (PMID) are shown. Although information is stored about the articles, PubMed/MEDLINE does not store the full text of the papers themselves. However, PubMedCentral (PMC) stores more than 2.8 million articles (roughly 10% of the articles in PubMed) and provides access to them for free to the users.

  4. 7 CFR 22.101 - The Rural Development Act of 1972 (Pub. L. 92-419).

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false The Rural Development Act of 1972 (Pub. L. 92-419). 22.101 Section 22.101 Agriculture Office of the Secretary of Agriculture RURAL DEVELOPMENT COORDINATION General § 22.101 The Rural Development Act of 1972 (Pub. L. 92-419). The Rural Development Act of...

  5. 一种基于社会学行为的Pub/Sub系统路由%Routing strategy based on sociology in Pub/Sub system

    Institute of Scientific and Technical Information of China (English)

    薛小平; 谭韵天; 王泽洪; 毕玉蓉; 闵妍妮

    2011-01-01

    为减少Pub/Sub系统中遍历广播的负载,基于社会学行为的小世界架构,提出了一种基于朋友圈的路由,给出了朋友圈划分算法以及基于朋友圈的Pub/Sub系统遍历算法,以限制消息在确定范围内传播,降低消息遍历的时间和广播开销.仿真实验表明,所提出的方法与Pub/Sub系统中传统的Gossip及洪泛法相比,可加快消息的传播速度,降低网络开销.%In order to reduce the overhead on the networks by traverse broadcast in the Pub/Sub systems, this paper proposed a routing strategy of friends circle based on a small world structure of sociology behavior. Proposed a partitioning algorithm and a traversing algorithm in the Pub / Sub systems based on friends circle, to realize the directional propagation of information,which reduced the time to traverse the whole network and lowered the broadcast overhead. Simulation results show that this routing algorithm can speed up spread efficiency and reduce overhead compared to the flooding and Gossip algorithm.

  6. Using PubMed in radiology: Ten useful tips for radiologists.

    Science.gov (United States)

    Sriganesh, Vasumathi

    2011-07-01

    PubMed contains a bibliography of articles published in around 4800 journals. It combines MEDLINE and OLDMEDLINE (articles from 1960, going back till the 1940s). PubMed is updated on a daily basis; to include both published and ahead of print references. As a radiologist, one can use PubMed to track several journals, track topics, search for specific topics, verify incomplete or incorrect references, store one's own publications, and save selected references; one can also create filters depending on one's own search needs for some regular topics. This article provides some key background knowledge on searching PubMed and also describes some features that are often left unexplored. The PubMed site has undergone many changes in the last few years and this article will update users on the current features.

  7. CoPub: a literature-based keyword enrichment tool for microarray data analysis

    Science.gov (United States)

    Frijters, Raoul; Heupers, Bart; van Beek, Pieter; Bouwhuis, Maurice; van Schaik, René; de Vlieg, Jacob; Polman, Jan; Alkema, Wynand

    2008-01-01

    Medline is a rich information source, from which links between genes and keywords describing biological processes, pathways, drugs, pathologies and diseases can be extracted. We developed a publicly available tool called CoPub that uses the information in the Medline database for the biological interpretation of microarray data. CoPub allows batch input of multiple human, mouse or rat genes and produces lists of keywords from several biomedical thesauri that are significantly correlated with the set of input genes. These lists link to Medline abstracts in which the co-occurring input genes and correlated keywords are highlighted. Furthermore, CoPub can graphically visualize differentially expressed genes and over-represented keywords in a network, providing detailed insight in the relationships between genes and keywords, and revealing the most influential genes as highly connected hubs. CoPub is freely accessible at http://services.nbic.nl/cgi-bin/copub/CoPub.pl. PMID:18442992

  8. Retrieving Clinical Evidence: A Comparison of PubMed and Google Scholar for Quick Clinical Searches

    Science.gov (United States)

    Bejaimal, Shayna AD; Sontrop, Jessica M; Iansavichus, Arthur V; Haynes, R Brian; Weir, Matthew A; Garg, Amit X

    2013-01-01

    Background Physicians frequently search PubMed for information to guide patient care. More recently, Google Scholar has gained popularity as another freely accessible bibliographic database. Objective To compare the performance of searches in PubMed and Google Scholar. Methods We surveyed nephrologists (kidney specialists) and provided each with a unique clinical question derived from 100 renal therapy systematic reviews. Each physician provided the search terms they would type into a bibliographic database to locate evidence to answer the clinical question. We executed each of these searches in PubMed and Google Scholar and compared results for the first 40 records retrieved (equivalent to 2 default search pages in PubMed). We evaluated the recall (proportion of relevant articles found) and precision (ratio of relevant to nonrelevant articles) of the searches performed in PubMed and Google Scholar. Primary studies included in the systematic reviews served as the reference standard for relevant articles. We further documented whether relevant articles were available as free full-texts. Results Compared with PubMed, the average search in Google Scholar retrieved twice as many relevant articles (PubMed: 11%; Google Scholar: 22%; P<.001). Precision was similar in both databases (PubMed: 6%; Google Scholar: 8%; P=.07). Google Scholar provided significantly greater access to free full-text publications (PubMed: 5%; Google Scholar: 14%; P<.001). Conclusions For quick clinical searches, Google Scholar returns twice as many relevant articles as PubMed and provides greater access to free full-text articles. PMID:23948488

  9. PubMed 2008新增检索功能探析%Analysis on New Retrieval Functions in PubMed 2008

    Institute of Scientific and Technical Information of China (English)

    李朝葵; 陶卫国

    2009-01-01

    介绍PubMed系统2008年新增检索功能,包括高级检索模式、引文检测功能以及经改进的自动词语匹配功能,同时对其进行分析与评论,指出各项新增功能的优势、局限性以及适用的情况,为用户更好地利用PubMed进行检索提供帮助.%The paper introduces new retrieval functions in PubMed 2008, including advanced search pattern, citation sensor and improved automatic term mapping, meanwhile the analysis and assessment on those new functions are originally revealed, it points out the advantages, limitations as well as applicable situations, so as to provide help for users.

  10. PubMed Included a Bibliometric Analysis of the Gastrectomy%PubMed收录胃切除术相关文献的计量学分析

    Institute of Scientific and Technical Information of China (English)

    麻立民; 王文亮

    2015-01-01

    On PubMed indexed nearly 10 years gastrectomy literature year, country, journal source, prolific author, main keyword statistics, and analyze the data in order to identify relevant literature gastrectomy distribution characteristics and research status.%对PubMed收录的近10年胃切除术相关文献的年份、国别、期刊来源、多产作者、主要主题词进行统计,并对有关数据进行分析,以明确胃切除术相关文献分布特点和研究现状。

  11. 利用PubMed的E-Utilities工具构建PubMed拟投稿期刊选择模型

    Institute of Scientific and Technical Information of China (English)

    王琳

    2011-01-01

    随着国际科技交流的日益广泛及研究评价中对学术出版要求的不断提高,我国有越来越多的科研人员期望能在国际性学术期刊上发表论文。为了提高向国外期刊投稿命中率,笔者利用PubMed的E—Utilities工具构建了PubMed拟投稿期刊选择模型,以供读者参考使用。

  12. Quantum-chemistry based calibration of the alkali metal cation series (Li(+)-Cs(+)) for large-scale polarizable molecular mechanics/dynamics simulations.

    Science.gov (United States)

    Dudev, Todor; Devereux, Mike; Meuwly, Markus; Lim, Carmay; Piquemal, Jean-Philip; Gresh, Nohad

    2015-02-15

    The alkali metal cations in the series Li(+)-Cs(+) act as major partners in a diversity of biological processes and in bioinorganic chemistry. In this article, we present the results of their calibration in the context of the SIBFA polarizable molecular mechanics/dynamics procedure. It relies on quantum-chemistry (QC) energy-decomposition analyses of their monoligated complexes with representative O-, N-, S-, and Se- ligands, performed with the aug-cc-pVTZ(-f) basis set at the Hartree-Fock level. Close agreement with QC is obtained for each individual contribution, even though the calibration involves only a limited set of cation-specific parameters. This agreement is preserved in tests on polyligated complexes with four and six O- ligands, water and formamide, indicating the transferability of the procedure. Preliminary extensions to density functional theory calculations are reported.

  13. 4,4'-Bipyridine-2-(carb-oxy-methyl-sulfan-yl)pyridine-3-carb-oxy-lic acid (1/1).

    Science.gov (United States)

    Jiang, Xian-Rong; Wang, Xiao-Juan; Feng, Yun-Long

    2010-11-27

    In the title co-crystal, C(10)H(8)N(2)·C(8)H(7)NO(4)S, the formate group is coplanar with the pyridyl ring of the acid [dihedral angle = 6.2 (7)°], while the carb-oxy-methyl-sulfanyl group makes a C-S-C-C torsion angle of 70.2 (1)° with the pyridine ring. The dihedral angle between the pyridyl rings of the 4,4'-bipyridine mol-ecule is 27.4 (1)°. The acid and the 4,4'-bipyridine mol-ecules are involved in hydrogen bonding via carb-oxy-lic O and pyridyl N atoms. The structure is further consolidated by inter-molecular C-H⋯O hydrogen bonds, generating a three-dimensional network.

  14. Crystal structure of 4-{[(2,4-di-hydroxy-benzyl-idene)amino]-meth-yl}cyclo-hexane-carb-oxy-lic acid.

    Science.gov (United States)

    Danish, Muhammad; Akbar, Saba; Tahir, Muhammad Nawaz; Butt, Rabia Ayub; Ashfaq, Muhammad

    2015-12-01

    In the title compound, C15H19NO4, the cyclo-hexyl ring adopts a chair conformation with both exocyclic C-C bonds in equatorial orientations. The dihedral angle between the basal plane of cyclo-hexyl ring and the 2,4-di-hydroxy-benzaldehyde moiety is 84.13 (13)°. An intra-molecular O-H⋯N hydrogen bonds closes an S(6) ring. In the crystal, Oc-H⋯Op (c = carb-oxy-lic acid, p = phenol) hydrogen bonds link the mol-ecules into [100] C(13) chains whereas an Op-H⋯Oc hydrogen bond generates [101] C(15) chains. Together, these bonds generate (010) sheets incorporating R 2 (2)(20) loops. Weak C-H⋯O and C-H⋯π inter-actions also occur.

  15. Quertle and KNALIJ: searching PubMed has never been so easy and effective.

    Science.gov (United States)

    Giglia, E

    2011-12-01

    Quertle and KNALIJ are two innovative tools created to search PubMed in a easier and more effective way. They dramatically reduce time to discover meaningful results. Quertle allows a semantic search in multiple biomedical databases (PubMed included) and runs a query via relationships between concepts, so that you retrieve at ease more pertinent results and can navigate them by "key concepts". KNALIJ is a visualization tool which searches PubMed and presents the results in the form of visual, interactive maps you can zoom, scale, and explore according to new paths.

  16. 新版PubMed引文检索功能及全文获取

    Institute of Scientific and Technical Information of China (English)

    杜永莉; 张晓燕

    2008-01-01

    本文介绍因特网上免费生物医学检索系统PubMed新版提供的引文查询功能.告知广大信息用户,可以利用这一检索途径检索部分被PubMed收录的著者或论文被引用情况,扩大引文查询的检索范围.此外,还介绍了如何快速检索和获取PubMed收录的期刊全文.

  17. Comparative Research on Retrieval Function of Google Scholar, Scirus and PubMed%Google Scholar、Scirus及PubMed检索功能对比研究

    Institute of Scientific and Technical Information of China (English)

    侯跃芳; 赵玉虹; 龚黛琛

    2009-01-01

    The paper gives a comparative analysis of retrieval function among PubMed, Google Scholar and Scims mainly form the following aspects: retrieval methods, retrieval results and output formats. Effects of retrieval are compared through 10 retrieval tests, and respective characteristics of three retrieval tools are analyzed. Google Scholar has the largest scope;PubMed has better retrieval function than the other two;in the aspect of result output, three retrieval tools have their own characteristics.%对比权威数据库PubMed及权威学术搜索工具Google Scholar、Scirus的检索功能,主要比较检索方法、检索结果、结果输出格式等方面的功能,利用10个题目的检索试验比较检索效果,并分析3种工具的各自特点.Google Scholar的收录范围最广;PubMed检索功能优于其它两种工具;在输出结果的格式方面,3种检索工具各具特色.

  18. 新版PubMed查找医学文献方法简介%INTRODUCTION OF NEW EDITION OF PubMed FOR MEDICAL REFERENCES

    Institute of Scientific and Technical Information of China (English)

    孙明玉

    2002-01-01

    @@ 新版PubMed系统是由美国国立生物技术中心(NCBI)开发的、于2000年4月开始用于检索MEDLINE、PreMEDLINE数据库(免费)的网上系统.其网址是: http://www.ncbi.nlm.nih.gov/pubmed [1

  19. [Use of PubMed to improve evidence-based medicine in routine urological practice].

    Science.gov (United States)

    Rink, M; Kluth, L A; Shariat, S F; Chun, F K; Fisch, M; Dahm, P

    2013-03-01

    Applying evidence-based medicine in daily clinical practice is the basis of patient-centered medicine and knowledge of accurate literature acquisition skills is necessary for informed clinical decision-making. PubMed is an easy accessible, free bibliographic database comprising over 21 million citations from the medical field, life-science journals and online books. The article summarizes the effective use of PubMed in routine urological clinical practice based on a common case scenario. This article explains the simple use of PubMed to obtain the best search results with the highest evidence. Accurate knowledge about the use of PubMed in routine clinical practice can improve evidence-based medicine and also patient treatment.

  20. PubMedPortable: A Framework for Supporting the Development of Text Mining Applications

    Science.gov (United States)

    Döring, Kersten; Grüning, Björn A.; Telukunta, Kiran K.; Thomas, Philippe; Günther, Stefan

    2016-01-01

    Information extraction from biomedical literature is continuously growing in scope and importance. Many tools exist that perform named entity recognition, e.g. of proteins, chemical compounds, and diseases. Furthermore, several approaches deal with the extraction of relations between identified entities. The BioCreative community supports these developments with yearly open challenges, which led to a standardised XML text annotation format called BioC. PubMed provides access to the largest open biomedical literature repository, but there is no unified way of connecting its data to natural language processing tools. Therefore, an appropriate data environment is needed as a basis to combine different software solutions and to develop customised text mining applications. PubMedPortable builds a relational database and a full text index on PubMed citations. It can be applied either to the complete PubMed data set or an arbitrary subset of downloaded PubMed XML files. The software provides the infrastructure to combine stand-alone applications by exporting different data formats, e.g. BioC. The presented workflows show how to use PubMedPortable to retrieve, store, and analyse a disease-specific data set. The provided use cases are well documented in the PubMedPortable wiki. The open-source software library is small, easy to use, and scalable to the user’s system requirements. It is freely available for Linux on the web at https://github.com/KerstenDoering/PubMedPortable and for other operating systems as a virtual container. The approach was tested extensively and applied successfully in several projects. PMID:27706202

  1. PubMed收录的医学信息学英文期刊分析

    Institute of Scientific and Technical Information of China (English)

    冀玉静; 苏连花

    2005-01-01

    通过检索PubMed期刊数据库得到PubMed收录的医学信息学英文期刊,并利用Google 搜索引擎查询这些期刊的网址,从中总结整理出部分有代表性期刊的基本信息进行分析,以期对相关科研人员有所裨益.

  2. GOClonto: an ontological clustering approach for conceptualizing PubMed abstracts.

    Science.gov (United States)

    Zheng, Hai-Tao; Borchert, Charles; Kim, Hong-Gee

    2010-02-01

    Concurrent with progress in biomedical sciences, an overwhelming of textual knowledge is accumulating in the biomedical literature. PubMed is the most comprehensive database collecting and managing biomedical literature. To help researchers easily understand collections of PubMed abstracts, numerous clustering methods have been proposed to group similar abstracts based on their shared features. However, most of these methods do not explore the semantic relationships among groupings of documents, which could help better illuminate the groupings of PubMed abstracts. To address this issue, we proposed an ontological clustering method called GOClonto for conceptualizing PubMed abstracts. GOClonto uses latent semantic analysis (LSA) and gene ontology (GO) to identify key gene-related concepts and their relationships as well as allocate PubMed abstracts based on these key gene-related concepts. Based on two PubMed abstract collections, the experimental results show that GOClonto is able to identify key gene-related concepts and outperforms the STC (suffix tree clustering) algorithm, the Lingo algorithm, the Fuzzy Ants algorithm, and the clustering based TRS (tolerance rough set) algorithm. Moreover, the two ontologies generated by GOClonto show significant informative conceptual structures.

  3. Best, Useful and Objective Precisions for Information Retrieval of Three Search Methods in PubMed and iPubMed

    Directory of Open Access Journals (Sweden)

    Somayyeh Nadi Ravandi

    2016-10-01

    Full Text Available MEDLINE is one of the valuable sources of medical information on the Internet. Among the different open access sites of MEDLINE, PubMed is the best-known site. In 2010, iPubMed was established with an interaction-fuzzy search method for MEDLINE access. In the present work, we aimed to compare the precision of the retrieved sources (Best, Useful and Objective precision in the PubMed and iPubMed using two search methods (simple and MeSH search in PubMed and interaction-fuzzy method in iPubmed. During our semi-empirical study period, we held training workshops for 61 students of higher education to teach them Simple Search, MeSH Search, and Fuzzy-Interaction Search methods. Then, the precision of 305 searches for each method prepared by the students was calculated on the basis of Best precision, Useful precision, and Objective precision formulas. Analyses were done in SPSS version 11.5 using the Friedman and Wilcoxon Test, and three precisions obtained with the three precision formulas were studied for the three search methods. The mean precision of the interaction-fuzzy Search method was higher than that of the simple search and MeSH search for all three types of precision, i.e., Best precision, Useful precision, and Objective precision, and the Simple search method was in the next rank, and their mean precisions were significantly different (P < 0.001. The precision of the interaction-fuzzy search method in iPubmed was investigated for the first time. Also for the first time, three types of precision were evaluated in PubMed and iPubmed. The results showed that the Interaction-Fuzzy search method is more precise than using the natural language search (simple search and MeSH search, and users of this method found papers that were more related to their queries; even though search in Pubmed is useful, it is important that users apply new search methods to obtain the best results.

  4. Adei .pub

    African Journals Online (AJOL)

    User

    an activity characterized by a very wide range of operations of livelihood ... packaging and merchandising or retailing. (Carmen and ..... required temperature needed by the chicks and also to protect them .... Veterinary Doctor. 1. 1. Motorbike. 1.

  5. An automatic method to generate domain-specific investigator networks using PubMed abstracts

    Directory of Open Access Journals (Sweden)

    Gwinn Marta

    2007-06-01

    Full Text Available Abstract Background Collaboration among investigators has become critical to scientific research. This includes ad hoc collaboration established through personal contacts as well as formal consortia established by funding agencies. Continued growth in online resources for scientific research and communication has promoted the development of highly networked research communities. Extending these networks globally requires identifying additional investigators in a given domain, profiling their research interests, and collecting current contact information. We present a novel strategy for building investigator networks dynamically and producing detailed investigator profiles using data available in PubMed abstracts. Results We developed a novel strategy to obtain detailed investigator information by automatically parsing the affiliation string in PubMed records. We illustrated the results by using a published literature database in human genome epidemiology (HuGE Pub Lit as a test case. Our parsing strategy extracted country information from 92.1% of the affiliation strings in a random sample of PubMed records and in 97.0% of HuGE records, with accuracies of 94.0% and 91.0%, respectively. Institution information was parsed from 91.3% of the general PubMed records (accuracy 86.8% and from 94.2% of HuGE PubMed records (accuracy 87.0. We demonstrated the application of our approach to dynamic creation of investigator networks by creating a prototype information system containing a large database of PubMed abstracts relevant to human genome epidemiology (HuGE Pub Lit, indexed using PubMed medical subject headings converted to Unified Medical Language System concepts. Our method was able to identify 70–90% of the investigators/collaborators in three different human genetics fields; it also successfully identified 9 of 10 genetics investigators within the PREBIC network, an existing preterm birth research network. Conclusion We successfully created a

  6. A systematic review of economic evaluations of CHW interventions aimed at improving child health outcomes.

    Science.gov (United States)

    Nkonki, L; Tugendhaft, A; Hofman, K

    2017-02-28

    Evidence of the cost-effectiveness of community health worker interventions is pertinent for decision-makers and programme planners who are turning to community services in order to strengthen health systems in the context of the momentum generated by strategies to support universal health care, the post-2015 Sustainable Development Goal agenda.We conducted a systematic review of published economic evaluation studies of community health worker interventions aimed at improving child health outcomes. Four public health and economic evaluation databases were searched for studies that met the inclusion criteria: National Health Service Economic Evaluation Database (NHS EED), Cochrane, Paediatric Economic Evaluation Database (PEED), and PubMed. The search strategy was tailored to each database.The 19 studies that met the inclusion criteria were conducted in either high income countries (HIC), low- income countries (LIC) and/or middle-income countries (MIC). The economic evaluations covered a wide range of interventions. Studies were grouped together by intended outcome or objective of each study. The data varied in quality. We found evidence of cost-effectiveness of community health worker (CHW) interventions in reducing malaria and asthma, decreasing mortality of neonates and children, improving maternal health, increasing exclusive breastfeeding and improving malnutrition, and positively impacting physical health and psychomotor development amongst children.Studies measured varied outcomes, due to the heterogeneous nature of studies included; a meta-analysis was not conducted. Outcomes included disease- or condition -specific outcomes, morbidity, mortality, and generic measures (e.g. disability-adjusted life years (DALYs)). Nonetheless, all 19 interventions were found to be either cost-effective or highly cost-effective at a threshold specific to their respective countries.There is a growing body of economic evaluation literature on cost-effectiveness of CHW

  7. PubMed系统特殊服务功能应用概述%Summaries on the Application of Special Service Functions of the PubMed System

    Institute of Scientific and Technical Information of China (English)

    叶协杰; 王泽武

    2006-01-01

    美国医学图书馆(NLM)开发的PubMed是我国医学科技人员最常使用的一个生物医学文献检索系统,本文针对PubMed实际应用中的问题,主要介绍了该系统几项特殊服务功能的应用方法,包括期刊数据库、医学主题词数据库、单引文匹配器、批引文匹配器、临床咨询、外部链接和存储器等,旨在为需求者提供一些有益的帮助.

  8. Bibliometrics Analysis of Documents of AIDS Collected by PubMed%PubMed收录艾滋病相关文献的计量学分析

    Institute of Scientific and Technical Information of China (English)

    曹世君

    2008-01-01

    通过对1998~2007年PubMed所收录的艾滋病相关文献的年代、国别、期刊来源、作者、主题词及副主题词进行统计分析,从而了解近10年来艾滋病的研究现状,揭示对其研究的发展规律.

  9. Pub/Sub系统中基于免疫的新型路由算法%A New Immunity-Based Routing Strategy in Pub/Sub System

    Institute of Scientific and Technical Information of China (English)

    王泽洪; 闵妍妮; 刘名扬; 谭韵天

    2012-01-01

    In order to reduce the overhead on the networks by traverse broadcast in the Pub/Sub systems, introduced a new routing algorithm based on immunity. The first stage,select the initial immunity nodes based on the degree threshold 8. The second stage,select core agent nodes and immunity nodes by voting mechanism further. Simulation shows that the immunity routing can reduce the network load and increase the system' s scalability compared with flooding and epidemic and enhance network expansibility. The new immunity-based routing strategy can speed up the message transform, and reduce load.%为减少Pub/Sub系统中因遍历节点而产生的广播负载,在无标度网络的Pub/Sub系统遍历路由的基础上,提出了基于免疫思想的新型路由算法.第一阶段,通过设置阈值δ,选择初始免疫节点;第二阶段,通过投票机制进一步甄选核心代理节点和免疫节点.仿真实验表明所提出的方法与Pub/Sub系统中传统的Gossip算法及洪泛算法相比较,能够限制消息在确定的范围内传播并且降低消息遍历的时间和广播开销的负载.基于免疫的新型路由算法可加快消息的传播速度、降低网络开销.

  10. 48 CFR 1519.705-70 - Synopsis of contracts containing Pub. L. 95-507 subcontracting plans and goals.

    Science.gov (United States)

    2010-10-01

    ... containing Pub. L. 95-507 subcontracting plans and goals. 1519.705-70 Section 1519.705-70 Federal Acquisition... containing Pub. L. 95-507 subcontracting plans and goals. The synopsis of contract award, where applicable... and goals....

  11. Improving accuracy for identifying related PubMed queries by an integrated approach.

    Science.gov (United States)

    Lu, Zhiyong; Wilbur, W John

    2009-10-01

    PubMed is the most widely used tool for searching biomedical literature online. As with many other online search tools, a user often types a series of multiple related queries before retrieving satisfactory results to fulfill a single information need. Meanwhile, it is also a common phenomenon to see a user type queries on unrelated topics in a single session. In order to study PubMed users' search strategies, it is necessary to be able to automatically separate unrelated queries and group together related queries. Here, we report a novel approach combining both lexical and contextual analyses for segmenting PubMed query sessions and identifying related queries and compare its performance with the previous approach based solely on concept mapping. We experimented with our integrated approach on sample data consisting of 1539 pairs of consecutive user queries in 351 user sessions. The prediction results of 1396 pairs agreed with the gold-standard annotations, achieving an overall accuracy of 90.7%. This demonstrates that our approach is significantly better than the previously published method. By applying this approach to a one day query log of PubMed, we found that a significant proportion of information needs involved more than one PubMed query, and that most of the consecutive queries for the same information need are lexically related. Finally, the proposed PubMed distance is shown to be an accurate and meaningful measure for determining the contextual similarity between biological terms. The integrated approach can play a critical role in handling real-world PubMed query log data as is demonstrated in our experiments.

  12. Science outreach on tap: insights and practices from three years ofDartmouth Science Pubs.

    Science.gov (United States)

    Hawley, R. L.; Serrell, N.; Tobery, C. E.; Riordan, S. A.

    2015-12-01

    The "Cafe Scientifique" (or "Science Cafe") has existed around theworld for decades. In an informal setting, one or more scientistsengage with a lay audience, typically over refreshments of some kind.These Science Cafes have taken many formats and taken place in manyvenues. Some feature a single presenter, some multiple; somecongregate in large venues, some small; some restrict the use of thepowerpoint slides, some do not.Our team at Dartmouth has hosted "Science Pubs" for three years. OurScience Pub takes place in a local pub, from 5-7pm on a weekday once amonth. We choose a theme for a pub and select three presenters. Thecomposition of our panel varies, but we generally have at least onefaculty member and one "less-academic" member, such as a town plannerwhen discussing hurricanes or an organic farmer when discussingpesticides. Often we include a graduate student in the panel. ThePub takes place in three "acts": 1) the presenters each give a briefintroduction to thier take on the topic, usually 10-15 minutes,extemporaneous with no slides, 2) the "wedding reception" phase, whichis a break during which the presenters circulate to the pub tables,answering questions and chatting with the attendees informally, and 3)reconvening for a more 'formal' question and answer period duringwhich the presenters answer questions from the audience.Here, we outline the format that makes up a Dartmouth Science Pub andshare insignts and lessons learned. Among many findings, we havelearned: 1) a group of three presenters makes for a lively discussion,as often presenters 'riff' off one another's points, 2) it is cruicalto have a facilitator, to 'run the show', freeing the sciencepresenters to concentrate on thier audience engagement, and 3) a shortmeeting ahead of time with the presenters is simple and very importantin creating a smooth event, and serves to help the presenters 'codeswitch' and adapt language, in lieu of a formal 'training'.

  13. Countries' Biomedical Publications and Attraction Scores. A PubMed-based assessment.

    Science.gov (United States)

    Xu, Qinyi; Boggio, Andrea; Ballabeni, Andrea

    2014-01-01

    Studying publication volumes at the country level is key to understanding and improving a country's research system. PubMed is a public search engine of publications in all life sciences areas. Here, we show how this search engine can be used to assess the outputs of life science-related research by country. We have measured the numbers of publications during different time periods based on the country of affiliation of the first authors. Moreover, we have designed scores, which we have named Attraction Scores, to appraise the relative focus either toward particular types of studies, such as clinical trials or reviews, or toward specific research areas, such as public health and pharmacogenomics, or toward specific topics, for instance embryonic stem cells; we have also investigated a possible use of these Attraction Scores in connection with regulatory policies. We have weighed the statistics against general indicators such as country populations and gross domestic products (GDP). During the 5-year period 2008-2012, the United States was the country with the highest number of publications and Denmark the one with the highest number of publications per capita. Among the 40 countries with the highest GDPs, Israel had the highest publications-to-GDP ratio. Among the 20 countries with the most publications, Japan had the highest Attraction Score for induced pluripotent stem (iPS) cells and Italy the highest proportion of review publications. More than 50% of publications in English were from countries in which English is not the primary language. We show an assorted and extensive collection of rankings and charts that will inform scholars and policymakers in studying and improving the research systems both at the national and international level.

  14. MET network in PubMed: a text-mined network visualization and curation system

    Science.gov (United States)

    Dai, Hong-Jie; Su, Chu-Hsien; Lai, Po-Ting; Huang, Ming-Siang; Jonnagaddala, Jitendra; Rose Jue, Toni; Rao, Shruti; Chou, Hui-Jou; Milacic, Marija; Singh, Onkar; Syed-Abdul, Shabbir; Hsu, Wen-Lian

    2016-01-01

    Metastasis is the dissemination of a cancer/tumor from one organ to another, and it is the most dangerous stage during cancer progression, causing more than 90% of cancer deaths. Improving the understanding of the complicated cellular mechanisms underlying metastasis requires investigations of the signaling pathways. To this end, we developed a METastasis (MET) network visualization and curation tool to assist metastasis researchers retrieve network information of interest while browsing through the large volume of studies in PubMed. MET can recognize relations among genes, cancers, tissues and organs of metastasis mentioned in the literature through text-mining techniques, and then produce a visualization of all mined relations in a metastasis network. To facilitate the curation process, MET is developed as a browser extension that allows curators to review and edit concepts and relations related to metastasis directly in PubMed. PubMed users can also view the metastatic networks integrated from the large collection of research papers directly through MET. For the BioCreative 2015 interactive track (IAT), a curation task was proposed to curate metastatic networks among PubMed abstracts. Six curators participated in the proposed task and a post-IAT task, curating 963 unique metastatic relations from 174 PubMed abstracts using MET. Database URL: http://btm.tmu.edu.tw/metastasisway PMID:27242035

  15. Do smoke-free laws affect revenues in pubs and restaurants?

    Science.gov (United States)

    Melberg, Hans Olav; Lund, Karl E

    2012-02-01

    In the debate about laws regulating smoking in restaurants and pubs, there has been some controversy as to whether smoke-free laws would reduce revenues in the hospitality industry. Norway presents an interesting case for three reasons. First, it was among the first countries to implement smoke-free laws, so it is possible to assess the long-term effects. Second, it has a cold climate so if there is a negative effect on revenue one would expect to find it in Norway. Third, the data from Norway are detailed enough to distinguish between revenue from pubs and restaurants. Autoregressive integrated moving average (ARIMA) intervention analysis of bi-monthly observations of revenues in restaurants and pubs show that the law did not have a statistically significant long-term effect on revenue in restaurants or on restaurant revenue as a share of personal consumption. Similar analysis for pubs shows that there was no significant long-run effect on pub revenue.

  16. MET network in PubMed: a text-mined network visualization and curation system.

    Science.gov (United States)

    Dai, Hong-Jie; Su, Chu-Hsien; Lai, Po-Ting; Huang, Ming-Siang; Jonnagaddala, Jitendra; Rose Jue, Toni; Rao, Shruti; Chou, Hui-Jou; Milacic, Marija; Singh, Onkar; Syed-Abdul, Shabbir; Hsu, Wen-Lian

    2016-01-01

    Metastasis is the dissemination of a cancer/tumor from one organ to another, and it is the most dangerous stage during cancer progression, causing more than 90% of cancer deaths. Improving the understanding of the complicated cellular mechanisms underlying metastasis requires investigations of the signaling pathways. To this end, we developed a METastasis (MET) network visualization and curation tool to assist metastasis researchers retrieve network information of interest while browsing through the large volume of studies in PubMed. MET can recognize relations among genes, cancers, tissues and organs of metastasis mentioned in the literature through text-mining techniques, and then produce a visualization of all mined relations in a metastasis network. To facilitate the curation process, MET is developed as a browser extension that allows curators to review and edit concepts and relations related to metastasis directly in PubMed. PubMed users can also view the metastatic networks integrated from the large collection of research papers directly through MET. For the BioCreative 2015 interactive track (IAT), a curation task was proposed to curate metastatic networks among PubMed abstracts. Six curators participated in the proposed task and a post-IAT task, curating 963 unique metastatic relations from 174 PubMed abstracts using MET.Database URL: http://btm.tmu.edu.tw/metastasisway. © The Author(s) 2016. Published by Oxford University Press.

  17. Integrating mental health in primary healthcare in low-income countries

    DEFF Research Database (Denmark)

    Sørensen, Carina Winkler; Bæk, Ole; Kallestrup, Per

    2017-01-01

    . AIMS: This paper seeks to explore the rationale behind the WHO recommendations for improving mental health services in LICs. At the core of these recommendations is an integration of mental health services into existing primary healthcare. This article presents available research supporting...... from LICs that investigate mental health interventions is scarce. The evidence that does exist favours integration into primary healthcare. There is evidence that collaborative- and stepped-care interventions can provide viable treatment options for patients. CONCLUSION: Integration of mental health...... services into primary healthcare seems like a viable solution to ensure that treatment becomes more available, even though the evidence is limited. Locally conducted research is needed to guide the development of sustainable evidence-based mental health treatment, involving relevant healthcare providers...

  18. Crawling PubMed with web agents for literature search and alerting services

    Directory of Open Access Journals (Sweden)

    Carlos CARVALHAL

    2013-05-01

    Full Text Available In this paper we present ASAP - Automated Search with Agents in PubMed, a web-based service aiming to manage and automate scientific literature search in the PubMed database. The system allows the creation and management of web agents, parameterized thematically and functionally, that crawl the PubMed database autonomously and periodically, aiming to search and retrieve relevant results according the requirements provided by the user. The results, containing the publications list retrieved, are emailed to the agent owner on a weekly basis, during the activity period defined for the web agent. The ASAP service is devoted to help researchers, especially from the field of biomedicine and bioinformatics, in order to increase their productivity, and can be accessed at: http://esa.ipb.pt/~agentes.

  19. 从MEDLINE到PubMed检索过渡中的主要问题

    Institute of Scientific and Technical Information of China (English)

    何柏涛; 方习国

    2005-01-01

    MEDLINE是美国国立医学图书馆编辑的期刊索引与文摘数据库,收录了从1966开始、世界上70多个国家、近4500种期刊。PubMed是美国国立医学图书馆在INTERNET上提供的检索数据库,其中MEDLINE是PubMed的主要部分。PubMed比MEDLINE收录的文献更广(包括某些MEDLINE收录的期刊中非医学文献)、更新速度更快;

  20. Chronic Illness & Mental Health

    Science.gov (United States)

    ... is present. For More Information Share Chronic Illness & Mental Health Download PDF Download ePub Order a free hardcopy ... For more information, see the National Institute of Mental Health (NIMH) booklet on Depression at http://www.nimh. ...

  1. [Particulate matter in indoor environments--exposure situation in residences, schools, pubs, and related recreational spaces].

    Science.gov (United States)

    Fromme, H

    2006-11-01

    Numerous epidemiological studies have been carried out during the last decades which have demonstrated an association between the pollution of outside air with toxic substances and the occurrence of health-related effects. Against the background of these findings, particularly in recent years, the focus of research has clearly shifted towards particulate matter (PM), notable fine and ultrafine particles. While diverse measurements of PM in the outside air have been conducted, only few data on indoor air pollution are available. The concentration of PM in the indoor environment is highly variable in time and space due to various influencing factors like type of the source, building and room characteristics, the activities of users and the airing behaviour. In this article we aim to summarise and discuss the exposure situation regarding PM in indoor environments. In residences, European studies have found mean PM (2.5) values between 10 and 87 microg/m (3). Especially in smokers' homes, a high background level was observed, reaching very high concentrations of some hundred microg/m (3) when active smoking took place. There are some studies on air quality in schools and similar public places which show that exposure to particulate matter in these environments is high. The main causes of this situation appear to be an insufficient ventilation routine as well as the low frequency and quality of cleaning. In combination with the high number of pupils in relation to room area and volume and their sometimes high physical activity, this leads to a continued resuspension of particles from the room's surfaces. A very high concentration of PM can be observed in those recreational places where smoking is not prohibited, such as discotheques, pubs and restaurants. Here, the mean PM values can reach some hundred microg/m (3). Specific strategies are necessary to especially protect the health of non-smokers in such places. Further investigations are needed to characterise the

  2. PubMed Medline 3: Elements de cerca i límits. Gener 2011

    OpenAIRE

    2011-01-01

    Tutorial sobre els elements de cerca i límits a la base de dades PubMed Medline,produïda per la National Library of Medicine. Conté articles de revistes relacionats amb la literatura biomèdica, la investigació i la pràctica clínica. La base de dades Medline conté les subbases: AIDS (abans Aidsline), Bioethics (abans Bioethicsline), Cancer (abans Cancerlit), Complementary Medicine, Core Clinical Journals, Dental Journals, History of Medicine, Nursing Journals, PubMed Central, OldMedline for Pr...

  3. PubMed Medline 4: La cerca pel tesaurus MeSH. Novembre 2011

    OpenAIRE

    Universitat de Barcelona. CRAI

    2011-01-01

    Tutorial sobre Matèries MeSH de la base de dades PubMed Medline,produïda per la National Library of Medicine. Conté articles de revistes relacionats amb la literatura biomèdica, la investigació i la pràctica clínica. La base de dades Medline conté les subbases: AIDS (abans Aidsline), Bioethics (abans Bioethicsline), Cancer (abans Cancerlit), Complementary Medicine, Core Clinical Journals, Dental Journals, History of Medicine, Nursing Journals, PubMed Central, OldMedline for Pre 1966, Space Li...

  4. Bibliometrics analysis of dentin papers from PubMed%PubMed收录牙本质相关文献的计量学分析

    Institute of Scientific and Technical Information of China (English)

    姚丽芸

    2015-01-01

    Objective:Through the analysis of the bibliometrics,the author researched status of the dentin. Method:By the method of bibliometrics,the dentine related papers from PubMed database of the U.S. national medicine library were analyzed. Result:The year,country,source of periodicals,prolific writer and the Major Topic MeSH of dentin papers were an-alyzed,in order to make distribution characteristics and research status of dentine papers clear. Conclusion:Through the analysis of the bibliometrics,it is clear to distribution characteristics and research status of dentine papers.%目的:运用计量学分析方法分析牙本质的相关研究现状。方法:采用文献计量学方法对美国国立医学图书馆提供的PubMed数据库收录的牙本质相关文献进行分析。结果:对PubMed收录的牙本质相关文献的年份、国籍、期刊来源、多产作者、主题词进行统计,并对有关数据进行分析,以明确牙本质相关文献分布特点和研究现状。结论:通过计量学分析,明确牙本质文献分布特点和研究现状。

  5. Analysis of Rehabilitation Medicine Journals Included in JCR and PubMed%JCR和PubMed收录的康复医学期刊分析

    Institute of Scientific and Technical Information of China (English)

    林晓华; 钟伶; 林丹红

    2013-01-01

    基于SCI的康复医学款目描述及《医学主题词表》(MeSH)对康复的定义,对JCR(期刊引证报告)与PubMed收录的康复医学期刊进行整理与分析;介绍其中影响力较高的期刊,并与引文分析法所获取的该领域重要期刊进行对比分析,为康复医学领域的科研人员与康复临床人员提供参考.

  6. Benzene-1,2,4,5-tetra-carb-oxy-lic acid bis-(1,3,7-trimethyl-2,3,6,7-tetra-hydro-1H-purine-2,6-dione).

    Science.gov (United States)

    Arman, Hadi D; Tiekink, Edward R T

    2013-01-01

    The asymmetric unit of the title co-crystal, C10H6O8·2C8H10N4O2, comprises a centrosymmetric benzene-1,2,4,5-tetra-carb-oxy-lic acid (LH4) mol-ecule and a mol-ecule of caffeine in a general position. LH4 is nonplanar, with the dihedral angles between the ring and pendent carb-oxy-lic acid groups being 44.22 (7) and 49.74 (7)°. By contrast, the caffeine mol-ecule is planar (r.m.s. deviation = 0.040 Å). Supra-molecular layers parallel to (-1-10) are sustained by carb-oxy-lic acid O-H⋯O(carbon-yl) and O-H⋯N(imidazole) hydrogen bonds, as well as by meth-yl-carbonyl C-H⋯O inter-actions. These stack via π-π inter-actions between the benzene and imidazole rings [inter-centroid distance = 3.4503 (10) Å].

  7. Comparison of PubMed, Scopus, Web of Science, and Google Scholar: strengths and weaknesses.

    Science.gov (United States)

    Falagas, Matthew E; Pitsouni, Eleni I; Malietzis, George A; Pappas, Georgios

    2008-02-01

    The evolution of the electronic age has led to the development of numerous medical databases on the World Wide Web, offering search facilities on a particular subject and the ability to perform citation analysis. We compared the content coverage and practical utility of PubMed, Scopus, Web of Science, and Google Scholar. The official Web pages of the databases were used to extract information on the range of journals covered, search facilities and restrictions, and update frequency. We used the example of a keyword search to evaluate the usefulness of these databases in biomedical information retrieval and a specific published article to evaluate their utility in performing citation analysis. All databases were practical in use and offered numerous search facilities. PubMed and Google Scholar are accessed for free. The keyword search with PubMed offers optimal update frequency and includes online early articles; other databases can rate articles by number of citations, as an index of importance. For citation analysis, Scopus offers about 20% more coverage than Web of Science, whereas Google Scholar offers results of inconsistent accuracy. PubMed remains an optimal tool in biomedical electronic research. Scopus covers a wider journal range, of help both in keyword searching and citation analysis, but it is currently limited to recent articles (published after 1995) compared with Web of Science. Google Scholar, as for the Web in general, can help in the retrieval of even the most obscure information but its use is marred by inadequate, less often updated, citation information.

  8. Information architecture: study and analysis of data Public Medical base (PubMed

    Directory of Open Access Journals (Sweden)

    Odete Máyra Mesquita Sales

    2016-07-01

    Full Text Available Objective. Based on principles proposed by Rosenfeld and Morville (2006, the present study examined the PubMed database interface, since a well-structured information architecture contributes to good usability in any digital environment. Method. The research development occurred through the use of literature techniques and empirical study on the analysis of information architecture based on organization, navigation, recommended labeling and search for Rosenfeld and Morville (2006 for the sake of usability base PubMed. For better understanding and description of these principles, we used the technique of content analysis. Results. The results showed that the database interface meets the criteria established by the elements of Information Architecture, such as organization based on hypertext structure, horizontal menu and local content divided into categories, identifying active links, global navigation , breadcrumb, textual labeling and iconographic and highlight the search engine. Conclusions. This research showed that the PubMed database interface is well structured, friendly and objective, with numerous possibilities of search and information retrieval. However, there is a need to adopt accessibility standards on this website, so that it reaches more efficiently its purpose of facilitating access to information organized and stored in the PubMed database.

  9. Web search and data mining of natural products and their bioactivities in PubChem.

    Science.gov (United States)

    Ming, Hao; Tiejun, Cheng; Yanli, Wang; Stephen, Bryant H

    2013-10-01

    Natural products, as major resources for drug discovery historically, are gaining more attentions recently due to the advancement in genomic sequencing and other technologies, which makes them attractive and amenable to drug candidate screening. Collecting and mining the bioactivity information of natural products are extremely important for accelerating drug development process by reducing cost. Lately, a number of publicly accessible databases have been established to facilitate the access to the chemical biology data for small molecules including natural products. Thus, it is imperative for scientists in related fields to exploit these resources in order to expedite their researches on natural products as drug leads/candidates for disease treatment. PubChem, as a public database, contains large amounts of natural products associated with bioactivity data. In this review, we introduce the information system provided at PubChem, and systematically describe the applications for a set of PubChem web services for rapid data retrieval, analysis, and downloading of natural products. We hope this work can serve as a starting point for the researchers to perform data mining on natural products using PubChem.

  10. Evaluation of PubMed filters used for evidence-based searching: validation using relative recall.

    NARCIS (Netherlands)

    Hoogendam, A.; Vries Robbe, P.F. de; Stalenhoef, A.F.H.; Overbeke, A.J.P.M.

    2009-01-01

    OBJECTIVES: The research sought to determine the value of PubMed filters and combinations of filters in literature selected for systematic reviews on therapy-related clinical questions. METHODS: References to 35,281 included and 48,514 excluded articles were extracted from 2,629 reviews published

  11. A Window on the (Changing) Neighbourhood : The Role of Pubs in the Contested Spaces of Gentrification

    NARCIS (Netherlands)

    Ernst, O.; Doucet, B.

    2014-01-01

    This paper examines the effects of gentrification through the lens of the interactions and perceptions which can be found in local, neighbourhood pubs. By interviewing predominantly Dutch, non-gentrifying customers in the rapidly gentrifying Indische Buurt neighbourhood in Amsterdam, we uncovered di

  12. Matching Medline/PubMed data with Web of Science: a routine in R language

    NARCIS (Netherlands)

    Rotolo, D.; Leydesdorff, L.

    2015-01-01

    We present a novel routine, namely medlineR, based on the R language, that allows the user to match data from Medline/PubMed with records indexed in the ISI Web of Science (WoS) database. The matching allows exploiting the rich and controlled vocabulary of medical subject headings (MeSH) of Medline/

  13. Risk factors for bladder cancer: challenges of conducting a literature search using PubMed.

    Science.gov (United States)

    Joshi, Ashish; Preslan, Elicia

    2011-04-01

    The objective of this study was to assess the risk factors for bladder cancer using PubMed articles from January 2000 to December 2009. The study also aimed to describe the challenges encountered in the methodology of a literature search for bladder cancer risk factors using PubMed. Twenty-six categories of risk factors for bladder cancer were identified using the National Cancer Institute Web site and the Medical Subject Headings (MeSH) Web site. A total of 1,338 PubMed searches were run using the term "urinary bladder cancer" and a risk factor term (e.g., "cigarette smoking") and were screened to identify 260 articles for final analysis. The search strategy had an overall precision of 3.42 percent, relative recall of 12.64 percent, and an F-measure of 5.39 percent. Although search terms derived from MeSH had the highest overall precision and recall, the differences did not reach significance, which indicates that for generalized, free-text searches of the PubMed database, the searchers' own terms are generally as effective as MeSH terms.

  14. Finding translational science publications in MEDLINE/PubMed with translational science filters.

    Science.gov (United States)

    Fontelo, Paul; Liu, Fang

    2011-12-01

    Translational Science Search (TSS; http://tscience.nlm.nih.gov) is a web application for finding MEDLINE/PubMed journal articles that are regarded by their authors as novel, promising, or may have potential clinical application. A set of "translational" filters and related terms was created by reviewing journal articles published in clinical and translational science (TS) journals. Through E-Utilities, a user's query and TS filters are submitted to PubMed, and then, the retrieved PubMed citations are matched with a database of MeSH terms (for disease conditions) and RxNorm (for interventions) to locate the search term, translational filters found, and associated interventions in the title and abstract. An algorithm ranks the interventions and conditions, and then highlights them in the results page for quick reading and evaluation. Using previously searched terms and standard formulas, the precision and recall of TSS were 0.99 and 0.47, compared to 0.58 and 1.0 for PubMed Entrez, respectively.

  15. Rate of complications in scoliosis surgery – a systematic review of the Pub Med literature

    Directory of Open Access Journals (Sweden)

    Goodall Deborah

    2008-08-01

    Full Text Available Abstract Background Spinal fusion surgery is currently recommended when curve magnitude exceeds 40–45 degrees. Early attempts at spinal fusion surgery which were aimed to leave the patients with a mild residual deformity, failed to meet such expectations. These aims have since been revised to the more modest goals of preventing progression, restoring 'acceptability' of the clinical deformity and reducing curvature. In view of the fact that there is no evidence that health related signs and symptoms of scoliosis can be altered by spinal fusion in the long-term, a clear medical indication for this treatment cannot be derived. Knowledge concerning the rate of complications of scoliosis surgery may enable us to establish a cost/benefit relation of this intervention and to improve the standard of the information and advice given to patients. It is also hoped that this study will help to answer questions in relation to the limiting choice between the risks of surgery and the "wait and see – observation only until surgery might be recommended", strategy widely used. The purpose of this review is to present the actual data available on the rate of complications in scoliosis surgery. Materials and methods Search strategy for identification of studies; Pub Med and the SOSORT scoliosis library, limited to English language and bibliographies of all reviewed articles. The search strategy included the terms; 'scoliosis'; 'rate of complications'; 'spine surgery'; 'scoliosis surgery'; 'spondylodesis'; 'spinal instrumentation' and 'spine fusion'. Results The electronic search carried out on the 1st February 2008 with the key words "scoliosis", "surgery", "complications" revealed 2590 titles, which not necessarily attributed to our quest for the term "rate of complications". 287 titles were found when the term "rate of complications" was used as a key word. Rates of complication varied between 0 and 89% depending on the aetiology of the entity investigated

  16. Data mining a small molecule drug screening representative subset from NIH PubChem.

    Science.gov (United States)

    Xie, Xiang-Qun; Chen, Jian-Zhong

    2008-03-01

    PubChem is a scientific showcase of the NIH Roadmap Initiatives. It is a compound repository created to facilitate information exchange and data sharing among the NIH Roadmap-funded Molecular Library Screening Center Network (MLSCN) and the scientific community. However, PubChem has more than 10 million records of compound information. It will be challenging to conduct a drug screening of the whole database of millions of compounds. Thus, the purpose of the present study was to develop a data mining cheminformatics approach in order to construct a representative and structure-diverse sublibrary from the large PubChem database. In this study, a new chemical diverse representative subset, rePubChem, was selected by whole-molecule chemistry-space matrix calculation using the cell-based partition algorithm. The representative subset was generated and was then subjected to evaluations by compound property analyses based on 1D and 2D molecular descriptors. The new subset was also examined and assessed for self-similarity analysis based on 2D molecular fingerprints in comparing with the source compound library. The new subset has a much smaller library size (540K compounds) with minimum similarity and redundancy without loss of the structural diversity and basic molecular properties of its parent library (5.3 million compounds). The new representative subset library generated could be a valuable structure-diverse compound resource for in silico virtual screening and in vitro HTS drug screening. In addition, the established subset generation method of using the combined cell-based chemistry-space partition metrics with pairwised 2D fingerprint-based similarity search approaches will also be important to a broad scientific community interested in acquiring structurally diverse compounds for efficient drug screening, building representative virtual combinatorial chemistry libraries for syntheses, and data mining large compound databases like the PubChem library in general.

  17. Impact of PubMed search filters on the retrieval of evidence by physicians.

    Science.gov (United States)

    Shariff, Salimah Z; Sontrop, Jessica M; Haynes, R Brian; Iansavichus, Arthur V; McKibbon, K Ann; Wilczynski, Nancy L; Weir, Matthew A; Speechley, Mark R; Thind, Amardeep; Garg, Amit X

    2012-02-21

    Physicians face challenges when searching PubMed for research evidence, and they may miss relevant articles while retrieving too many nonrelevant articles. We investigated whether the use of search filters in PubMed improves searching by physicians. We asked a random sample of Canadian nephrologists to answer unique clinical questions derived from 100 systematic reviews of renal therapy. Physicians provided the search terms that they would type into PubMed to locate articles to answer these questions. We entered the physician-provided search terms into PubMed and applied two types of search filters alone or in combination: a methods-based filter designed to identify high-quality studies about treatment (clinical queries "therapy") and a topic-based filter designed to identify studies with renal content. We evaluated the comprehensiveness (proportion of relevant articles found) and efficiency (ratio of relevant to nonrelevant articles) of the filtered and nonfiltered searches. Primary studies included in the systematic reviews served as the reference standard for relevant articles. The average physician-provided search terms retrieved 46% of the relevant articles, while 6% of the retrieved articles were relevant (corrected) (the ratio of relevant to nonrelevant articles was 1:16). The use of both filters together produced a marked improvement in efficiency, resulting in a ratio of relevant to nonrelevant articles of 1:5 (16 percentage point improvement; 99% confidence interval 9% to 22%; p articles found; p = 0.55). The use of PubMed search filters improves the efficiency of physician searches. Improved search performance may enhance the transfer of research into practice and improve patient care.

  18. Impact of PubMed search filters on the retrieval of evidence by physicians

    Science.gov (United States)

    Shariff, Salimah Z.; Sontrop, Jessica M.; Haynes, R. Brian; Iansavichus, Arthur V.; McKibbon, K. Ann; Wilczynski, Nancy L.; Weir, Matthew A.; Speechley, Mark R.; Thind, Amardeep; Garg, Amit X.

    2012-01-01

    Background: Physicians face challenges when searching PubMed for research evidence, and they may miss relevant articles while retrieving too many nonrelevant articles. We investigated whether the use of search filters in PubMed improves searching by physicians. Methods: We asked a random sample of Canadian nephrologists to answer unique clinical questions derived from 100 systematic reviews of renal therapy. Physicians provided the search terms that they would type into PubMed to locate articles to answer these questions. We entered the physician-provided search terms into PubMed and applied two types of search filters alone or in combination: a methods-based filter designed to identify high-quality studies about treatment (clinical queries “therapy”) and a topic-based filter designed to identify studies with renal content. We evaluated the comprehensiveness (proportion of relevant articles found) and efficiency (ratio of relevant to nonrelevant articles) of the filtered and nonfiltered searches. Primary studies included in the systematic reviews served as the reference standard for relevant articles. Results: The average physician-provided search terms retrieved 46% of the relevant articles, while 6% of the retrieved articles were nonrelevant (the ratio of relevant to nonrelevant articles was 1:16). The use of both filters together produced a marked improvement in efficiency, resulting in a ratio of relevant to nonrelevant articles of 1:5 (16 percentage point improvement; 99% confidence interval 9% to 22%; p < 0.003) with no substantive change in comprehensiveness (44% of relevant articles found; p = 0.55). Interpretation: The use of PubMed search filters improves the efficiency of physician searches. Improved search performance may enhance the transfer of research into practice and improve patient care. PMID:22249990

  19. Author Disambiguation in PubMed: Evidence on the Precision and Recall of Author-ity among NIH-Funded Scientists.

    Directory of Open Access Journals (Sweden)

    Marc J Lerchenmueller

    Full Text Available We examined the usefulness (precision and completeness (recall of the Author-ity author disambiguation for PubMed articles by associating articles with scientists funded by the National Institutes of Health (NIH. In doing so, we exploited established unique identifiers-Principal Investigator (PI IDs-that the NIH assigns to funded scientists. Analyzing a set of 36,987 NIH scientists who received their first R01 grant between 1985 and 2009, we identified 355,921 articles appearing in PubMed that would allow us to evaluate the precision and recall of the Author-ity disambiguation. We found that Author-ity identified the NIH scientists with 99.51% precision across the articles. It had a corresponding recall of 99.64%. Precision and recall, moreover, appeared stable across common and uncommon last names, across ethnic backgrounds, and across levels of scientist productivity.

  20. PubMed收录国内5种大学医学学报论文计量分析%Bibliometric analysis of 5 journals indexed PubMed from Chinese medical universities

    Institute of Scientific and Technical Information of China (English)

    黄开颜; 陈清

    2011-01-01

    By GoPubMed as retrieval tool, 5 journals indexed PubMed in Chinese medical universities from 2003 to2010 are objective. Some bibliometric indexes from the 5 journals were collected, compared and analyzed as following: the number of articles, the percentage of articles indexed by PubMed, the city distribution of articles and high-frequency words of articles by PubMed.%应用GoPubMed检索工具,对PubMed收录的国内5种大学医学学报2003-2010年论文进行文献计量学研究,比较各刊发文数、PubMed收摘率、城市分布、高频词等。结果发现《南方医科大学学报》发文数及PubMed收录篇数最多,且城市分布较广,《中南大学学报(医学版)》PubMed收摘率最高,《南方医科大学学报》《北京大学学报(医学版)》《中南大学学报(医学版)》3种学报以人类和患者为研究对象的临床医学方面的论文比例较大。

  1. PUB13, a U-box/ARM E3 ligase, regulates plant defense, cell death, and flowering time.

    Science.gov (United States)

    Li, Wei; Dai, Liangying; Wang, Guo-Liang

    2012-08-01

    The ubiquitination pathway is involved in a variety of cellular processes in plant growth, development, and immune responses. However, the function of this pathway in connecting plant development and innate immunity is still largely unknown. Recently, we characterized the U-box/ARM E3 ubiquitin ligase PUB13, which regulates both immune responses and flowering time in Arabidopsis. Here, we show that the rice Spl11 gene can complement the cell death and flowering functions of PUB13 in the pub13 mutant. In addition, HFR1, which functions mainly in photomorphogenesis, was identified as one of the PUB13-interacting proteins through yeast two-hybrid screening and pull-down assays. Because the flowering phenotype of pub13 depends on photoperiod, we propose that PUB13 may regulate HFR1 to fine-tune photomorphogenesis and flowering time in Arabidopsis.

  2. 我国政府医疗卫生支出相对不足的计量检验%Econometric Test on the Government Health Expenditure Relative Deficiency in China

    Institute of Scientific and Technical Information of China (English)

    徐晓飞; 杨卫华

    2014-01-01

    Along with the gradual vanishing demographic dividend , China is faced with the challenge of serious popula-tion aging .The aggravated population aging will require medical and health service support services .Using the panel da-ta of 1997-2011 China′s 31 regions and the system GMM dynamic panel estimation method estimates the relationship between the population aging and government health expenditure .Through the analysis we can see that the government health expenditure is relatively insufficient , can not fully meet the needs of the aging population .The introduction of pub-lic-private partnerships not only can make up for the lack of government health expenditure , but also can make the pop-ulation aging supporting service system more perfect .%伴随着人口红利的逐步消逝,我国面临着严重的人口老龄化挑战。人口老龄化的加剧必然要求医疗卫生服务的进一步完善。本文运用1997-2011年我国31个地区的面板数据,采用系统GMM动态面板估计方法对人口老龄化与政府医疗卫生支出的关系进行估计,发现我国应对人口老龄化的政府医疗卫生支出相对不足,不能完全满足老龄人口的需要,而引入公私伙伴关系不仅可以弥补政府医疗卫生支出的不足,而且能够使人口老龄化的配套服务体系更加完善。

  3. Links to Other DBs (based on PubChem) - NBDC NikkajiRDF | LSDB Archive [Life Science Database Archive metadata

    Lifescience Database Archive (English)

    Full Text Available imple search URL - Data acquisition method The data was created from the mapping ...List Contact us NBDC NikkajiRDF Links to Other DBs (based on PubChem) Data detail Data name Links to Other D...ckathon ). Data file File name: NBDC_NikkajiRDF_link2OtherDBs_basedOnPubChem.tar.gz File URL: ftp://ftp.bios...ciencedbc.jp/archive/nikkaji/LATEST/NBDC_NikkajiRDF_link2OtherDBs_basedOnPubChem.tar.gz File size: 46.1 MB S... Policy | Contact Us Links to Other DBs (based on PubChem) - NBDC NikkajiRDF | LSDB Archive ...

  4. Dimethyl and diethyl esters of 5,6-bis-(pyridin-2-yl)pyrazine-2,3-di-carb-oxy-lic acid: a comparison.

    Science.gov (United States)

    Alfonso, Montserrat; Stoeckli-Evans, Helen

    2016-02-01

    In dimethyl 5,6-bis-(pyridin-2-yl)pyrazine-2,3-di-carboxyl-ate, C18H14N4O4, (I), and diethyl 5,6-bis-(pyridin-2-yl)pyrazine-2,3-di-carboxyl-ate, C20H18N4O4, (II), the dimethyl and diethyl esters of 5,6-bis-(pyridin-2-yl)pyrazine-2,3-di-carb-oxy-lic acid, the orientation of the two pyridine rings differ. In (I), pyridine ring B is inclined to pyrazine ring A by 44.8 (2)° and the pyridine and pyrazine N atoms are trans to one another, while pyridine ring C is inclined to the pyrazine ring by 50.3 (2)°, with the pyridine and pyrazine N atoms cis to one another. In compound (II), the diethyl ester, which possesses twofold rotation symmetry, the pyridine ring is inclined to the pyrazine ring by 40.7 (1)°, with the pyridine and pyrazine N atoms trans to one another. In the crystal of (I), mol-ecules are linked by C-H⋯N hydrogen bonds, forming chains along [001]. The chains are linked by C-H⋯π inter-actions, forming a three-dimensional structure. In the crystal of (II), mol-ecules are linked via C-H⋯O hydrogen bonds, forming a three-dimensional framework. There are C-H⋯π inter-actions present within the framework.

  5. Aging and social networks in Spain: the importance of pubs and churches.

    Science.gov (United States)

    Buz, José; Sanchez, Marta; Levenson, Michael R; Aldwin, Carolyn M

    2014-01-01

    We examined whether the social convoy model and socioemotional selectivity theory apply in collectivistic cultures by examining the contextual factors which are hypothesized to mediate age-related differences in social support in a collectivist European country. Five hundred Spanish community-dwelling older adults (Mean age = 74.78, SD = 7.76, range = 60-93) were interviewed to examine structural aspects of their social networks. We found that age showed highly complex relationships with network size and frequency of interaction, depending on the network circle and the mediation of cultural factors. Family structure was important for social relations in the inner circle, while pubs and churches were important for peripheral relations. Surprisingly, pub attendance was the most important variable for maintenance of social support of peripheral network members. In general, the results support the applicability of the social convoy and socioemotional selectivity constructs to social support among Spanish older adults.

  6. Number of monthly hits to WJG articles linked to PubMed surpasses 70000

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    @@ The latest data from LinkOut Team NCBI/US NLM show that the number of hits to World Journal of Gastroenterology (WJG) articles linked to LinkOut of PubMed reached 2 254327 during the period of April, 2004, to September,2007; further, the number was 72532 for the month of September, 2007, which was 7344 hits higher than that of the same period in 2006.

  7. An analysis of gene/protein associations at PubMed scale

    Directory of Open Access Journals (Sweden)

    Pyysalo Sampo

    2011-10-01

    Full Text Available Abstract Background Event extraction following the GENIA Event corpus and BioNLP shared task models has been a considerable focus of recent work in biomedical information extraction. This work includes efforts applying event extraction methods to the entire PubMed literature database, far beyond the narrow subdomains of biomedicine for which annotated resources for extraction method development are available. Results In the present study, our aim is to estimate the coverage of all statements of gene/protein associations in PubMed that existing resources for event extraction can provide. We base our analysis on a recently released corpus automatically annotated for gene/protein entities and syntactic analyses covering the entire PubMed, and use named entity co-occurrence, shortest dependency paths and an unlexicalized classifier to identify likely statements of gene/protein associations. A set of high-frequency/high-likelihood association statements are then manually analyzed with reference to the GENIA ontology. Conclusions We present a first estimate of the overall coverage of gene/protein associations provided by existing resources for event extraction. Our results suggest that for event-type associations this coverage may be over 90%. We also identify several biologically significant associations of genes and proteins that are not addressed by these resources, suggesting directions for further extension of extraction coverage.

  8. Dialysis search filters for PubMed, Ovid MEDLINE, and Embase databases.

    Science.gov (United States)

    Iansavichus, Arthur V; Haynes, R Brian; Lee, Christopher W C; Wilczynski, Nancy L; McKibbon, Ann; Shariff, Salimah Z; Blake, Peter G; Lindsay, Robert M; Garg, Amit X

    2012-10-01

    Physicians frequently search bibliographic databases, such as MEDLINE via PubMed, for best evidence for patient care. The objective of this study was to develop and test search filters to help physicians efficiently retrieve literature related to dialysis (hemodialysis or peritoneal dialysis) from all other articles indexed in PubMed, Ovid MEDLINE, and Embase. A diagnostic test assessment framework was used to develop and test robust dialysis filters. The reference standard was a manual review of the full texts of 22,992 articles from 39 journals to determine whether each article contained dialysis information. Next, 1,623,728 unique search filters were developed, and their ability to retrieve relevant articles was evaluated. The high-performance dialysis filters consisted of up to 65 search terms in combination. These terms included the words "dialy" (truncated), "uremic," "catheters," and "renal transplant wait list." These filters reached peak sensitivities of 98.6% and specificities of 98.5%. The filters' performance remained robust in an independent validation subset of articles. These empirically derived and validated high-performance search filters should enable physicians to effectively retrieve dialysis information from PubMed, Ovid MEDLINE, and Embase.

  9. Dialysis Search Filters for PubMed, Ovid MEDLINE, and Embase Databases

    Science.gov (United States)

    Iansavichus, Arthur V.; Haynes, R. Brian; Lee, Christopher W.C.; Wilczynski, Nancy L.; McKibbon, Ann; Shariff, Salimah Z.; Blake, Peter G.; Lindsay, Robert M.

    2012-01-01

    Summary Background and objectives Physicians frequently search bibliographic databases, such as MEDLINE via PubMed, for best evidence for patient care. The objective of this study was to develop and test search filters to help physicians efficiently retrieve literature related to dialysis (hemodialysis or peritoneal dialysis) from all other articles indexed in PubMed, Ovid MEDLINE, and Embase. Design, setting, participants, & measurements A diagnostic test assessment framework was used to develop and test robust dialysis filters. The reference standard was a manual review of the full texts of 22,992 articles from 39 journals to determine whether each article contained dialysis information. Next, 1,623,728 unique search filters were developed, and their ability to retrieve relevant articles was evaluated. Results The high-performance dialysis filters consisted of up to 65 search terms in combination. These terms included the words “dialy” (truncated), “uremic,” “catheters,” and “renal transplant wait list.” These filters reached peak sensitivities of 98.6% and specificities of 98.5%. The filters’ performance remained robust in an independent validation subset of articles. Conclusions These empirically derived and validated high-performance search filters should enable physicians to effectively retrieve dialysis information from PubMed, Ovid MEDLINE, and Embase. PMID:22917701

  10. PubMed医学信息资源及其检索

    Institute of Scientific and Technical Information of China (English)

    杨凝清

    2003-01-01

    @@ 由美国国家生物技术信息中心(National Center for Biotechnology Information,NCBI)所开发的网上MEDLINE系统--PubMed,以其界面友好及检索灵活、方便、准确,备受用户青睐.值得一提的是,PubMed作为循证医学的重要检索工具,在数据库建设和检索软件的开发过程中,提供比MEDLINE光盘检索更为方便、简捷的检索循证医学信息方式.作为医疗科研人员,应该熟悉和掌握其使用方法.本文对PubMed的信息资源状况、检索方法以及界面功能作一简单介绍.

  11. Precision and negative predictive value of links between ClinicalTrials.gov and PubMed.

    Science.gov (United States)

    Huser, Vojtech; Cimino, James J

    2012-01-01

    One of the goals of translational science is to shorten the time from discovery to clinical use. Clinical trial registries were established to increase transparency in completed and ongoing clinical trials, and they support linking trials with resulting publications. We set out to investigate precision and negative predictive value (NPV) of links between ClinicalTrials.gov (CT.gov) and PubMed. CT.gov has been established to increase transparency in clinical trials and the link to PubMed is crucial for supporting a number of important functions, including ascertaining publication bias. We drew a random sample of trials downloaded from CT.gov and performed manual review of retrieved publications. We characterize two types of links between trials and publications (NCT-link originating from MEDLINE and PMID-link originating from CT.gov).The link precision is different based on type (NCT-link: 100%; PMID-link: 63% to 96%). In trials with no linked publication, we were able to find publications 44% of the time (NPV=56%) by searching PubMed. This low NPV shows that there are potentially numerous publications that should have been formally linked with the trials. Our results indicate that existing trial registry and publisher policies may not be fully enforced. We suggest some automated methods for improving link quality.

  12. Discovering biomedical semantic relations in PubMed queries for information retrieval and database curation.

    Science.gov (United States)

    Huang, Chung-Chi; Lu, Zhiyong

    2016-01-01

    Identifying relevant papers from the literature is a common task in biocuration. Most current biomedical literature search systems primarily rely on matching user keywords. Semantic search, on the other hand, seeks to improve search accuracy by understanding the entities and contextual relations in user keywords. However, past research has mostly focused on semantically identifying biological entities (e.g. chemicals, diseases and genes) with little effort on discovering semantic relations. In this work, we aim to discover biomedical semantic relations in PubMed queries in an automated and unsupervised fashion. Specifically, we focus on extracting and understanding the contextual information (or context patterns) that is used by PubMed users to represent semantic relations between entities such as 'CHEMICAL-1 compared to CHEMICAL-2' With the advances in automatic named entity recognition, we first tag entities in PubMed queries and then use tagged entities as knowledge to recognize pattern semantics. More specifically, we transform PubMed queries into context patterns involving participating entities, which are subsequently projected to latent topics via latent semantic analysis (LSA) to avoid the data sparseness and specificity issues. Finally, we mine semantically similar contextual patterns or semantic relations based on LSA topic distributions. Our two separate evaluation experiments of chemical-chemical (CC) and chemical-disease (CD) relations show that the proposed approach significantly outperforms a baseline method, which simply measures pattern semantics by similarity in participating entities. The highest performance achieved by our approach is nearly 0.9 and 0.85 respectively for the CC and CD task when compared against the ground truth in terms of normalized discounted cumulative gain (nDCG), a standard measure of ranking quality. These results suggest that our approach can effectively identify and return related semantic patterns in a ranked order

  13. Key steps in developing a cognitive vaccine against traumatic flashbacks: visuospatial Tetris versus verbal Pub Quiz.

    Directory of Open Access Journals (Sweden)

    Emily A Holmes

    Full Text Available BACKGROUND: Flashbacks (intrusive memories of a traumatic event are the hallmark feature of Post Traumatic Stress Disorder, however preventative interventions are lacking. Tetris may offer a 'cognitive vaccine' [1] against flashback development after trauma exposure. We previously reported that playing the computer game Tetris soon after viewing traumatic material reduced flashbacks compared to no-task [1]. However, two criticisms need to be addressed for clinical translation: (1 Would all games have this effect via distraction/enjoyment, or might some games even be harmful? (2 Would effects be found if administered several hours post-trauma? Accordingly, we tested Tetris versus an alternative computer game--Pub Quiz--which we hypothesized not to be helpful (Experiments 1 and 2, and extended the intervention interval to 4 hours (Experiment 2. METHODOLOGY/PRINCIPAL FINDINGS: The trauma film paradigm was used as an experimental analog for flashback development in healthy volunteers. In both experiments, participants viewed traumatic film footage of death and injury before completing one of the following: (1 no-task control condition (2 Tetris or (3 Pub Quiz. Flashbacks were monitored for 1 week. Experiment 1: 30 min after the traumatic film, playing Tetris led to a significant reduction in flashbacks compared to no-task control, whereas Pub Quiz led to a significant increase in flashbacks. Experiment 2: 4 hours post-film, playing Tetris led to a significant reduction in flashbacks compared to no-task control, whereas Pub Quiz did not. CONCLUSIONS/SIGNIFICANCE: First, computer games can have differential effects post-trauma, as predicted by a cognitive science formulation of trauma memory. In both Experiments, playing Tetris post-trauma film reduced flashbacks. Pub Quiz did not have this effect, even increasing flashbacks in Experiment 1. Thus not all computer games are beneficial or merely distracting post-trauma - some may be harmful. Second, the

  14. Comparison on effect for searching medical references by PubMed and Google%PubMed与Google检索特定医学期刊文献的效果比较

    Institute of Scientific and Technical Information of China (English)

    刘国栋

    2005-01-01

    目的比较评价PubMed与Google以不同检索入口查找特定英文医学期刊文献的效果.方法随机选取10篇英文参考文献作为源数据,分别在PubMed、Google中使用5种检索项及其组合进行检索测试,根据结果出现位置打分.结果无论PubMed与Google,输入前3位作者姓名命中位置最靠前,5种入口有4种PubMed的得分高于Google.结论查找特定期刊文献应首先选择PubMed,输入前3位作者进行检索.

  15. 基于PubMed的Takotsubo心肌病研究热点分析%Bibliometric analysis of PubMed-based literature on research focus of Takotsubo cardiomyopathy

    Institute of Scientific and Technical Information of China (English)

    王占胜; 杨学成; 吴涛; 胡健

    2012-01-01

    目的:调查心尖球形综合征( takotsubo cardiomyopathy,TTC)研究文献,分析当前该主题的研究热点.方法:对PubMed数据库中2009~2011年发表的有关TTC的文献进行调查分析,统计主要主题词出现的频次,截取频次大于6次的主题词作为高频次主题词.两两统计高频次主题词在同一篇文献中出现的频率,形成主题词词篇矩阵,利用SPSS统计软件对矩阵进行聚类分析,通过分析各类的文献内容得到该主题的研究热点.结果:共检出近3年发表的有关TTC论文646篇,出现频次超过6次的主题词为34个,其中出现频次最高的主题词为TIC的诊断(为228次),通过对这34个高频次主题词聚类分析得到10个研究热点.结论:肾上腺肿瘤与TTC发病的关系、药物诱导的TTC、TTC发病与基因、TTC胸痛及冠脉病理、TTC的MRI诊断与药物治疗、TTC并发症、TTC与长QT间期综合征的关系及与心肌梗死的鉴别诊断、超声及放射性核素成像对TTC心功能的评价、TCC的放射诊断、治疗及蛛网膜下腔出血并发症与TCC,均为近3年TTC的研究热点.%AIM; To examine "hot" topics on Takotsubo cardiomyopathy (TTC) research by analyzing the related literature. METHODS: Articles related to TTC published in the PubMed database during the years 2009 to 2011 were selected. Subject heading (MeSH) terms of the articles were downloaded and the frequency of the major MeSH terms was statistically calculated. High-frequency MeSH terms in the literature formed the co-word matrix by the appearance frequency of a pair of MeSH terms in the same literature. The co-word analysis was used to cluster these medical MeSHs. The research focus was obtained after statistically analyzing the contents of each cluster. RESULTS: A total of 646 articles associated with TTC were found in the PubMed database and 34 MeSH terms appeared more than six times. The MeSH term " Takotsubo cardiomyopathy/diagnosis" was found with the highest

  16. 75 FR 55393 - Determination Under Section 1010(a) of the Supplemental Appropriations Act, 2010 (Pub. L. 111-212)

    Science.gov (United States)

    2010-09-10

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Determination Under Section 1010(a) of the Supplemental Appropriations Act, 2010 (Pub. L. 111-212) Pursuant to section 1010(a) of the Supplemental Appropriations Act, 2010 (Pub. L. 111-212) and the authority vested...

  17. [Limiting a Medline/PubMed query to the "best" articles using the JCR relative impact factor].

    Science.gov (United States)

    Avillach, P; Kerdelhué, G; Devos, P; Maisonneuve, H; Darmoni, S J

    2014-12-01

    Medline/PubMed is the most frequently used medical bibliographic research database. The aim of this study was to propose a new generic method to limit any Medline/PubMed query based on the relative impact factor and the A & B categories of the SIGAPS score. The entire PubMed corpus was used for the feasibility study, then ten frequent diseases in terms of PubMed indexing and the citations of four Nobel prize winners. The relative impact factor (RIF) was calculated by medical specialty defined in Journal Citation Reports. The two queries, which included all the journals in category A (or A OR B), were added to any Medline/PubMed query as a central point of the feasibility study. Limitation using the SIGAPS category A was larger than the when using the Core Clinical Journals (CCJ): 15.65% of PubMed corpus vs 8.64% for CCJ. The response time of this limit applied to the entire PubMed corpus was less than two seconds. For five diseases out of ten, limiting the citations with the RIF was more effective than with the CCJ. For the four Nobel prize winners, limiting the citations with the RIF was more effective than the CCJ. The feasibility study to apply a new filter based on the relative impact factor on any Medline/PubMed query was positive. Copyright © 2014 Elsevier Masson SAS. All rights reserved.

  18. Composición florística post disturbio natural en la zona cordillerana de Licán Ray, Región de La Araucanía, Chile.

    OpenAIRE

    2015-01-01

    Se presenta la composición florística de un área impactada por un disturbio natural, ubicada en la zona cordillerana de Licán Ray. La flora total se compone de 78 especies de plantas vasculares, de las cuales la mayor parte pertenece al grupo de las dicotiledóneas. En el origen geográfico sobresalen las especies nativas, sin embargo hay una importante presencia de elementos introducidos principalmente provenientes de Europa. Las formas de vida están dominadas en mayor medida por hierbas peren...

  19. Supra-molecular inter-actions in the 1:2 co-crystal of 4,4'-bipyridine and 3-chloro-thio-phene-2-carb-oxy-lic acid.

    Science.gov (United States)

    Prajina, Olakkandiyil; Thomas Muthiah, Packianathan; Geiger, David K

    2016-10-01

    The asymmetric unit of the title compound, 2C5H3ClO2S·C10H8N2, is comprised of a mol-ecule of 3-chloro-thio-phene-2-carb-oxy-lic acid (3TPC) and half of a mol-ecule of 4,4'-bi-pyridine (BPY). A distinctive O-H⋯N-based synthon is present. Cl⋯Cl and π-π stacking inter-actions further stabilize the crystal structure, forming a two-dimensional network parallel to the bc plane.

  20. Comparison of the reactivity of 2-Li-C6H4CH2NMe2 with MCl4 (M=Th, U): isolation of a thorium aryl complex or a uranium benzyne complex.

    Science.gov (United States)

    Seaman, Lani A; Pedrick, Elizabeth A; Tsuchiya, Takashi; Wu, Guang; Jakubikova, Elena; Hayton, Trevor W

    2013-09-27

    Why do U react like that? Reaction of 2-Li-C6H4CH2NMe2 with [MCl4(DME)n] (M=Th, n=2; M=U, n=0) results in the formation of a thorium aryl complex, [Th(2-C6H4CH2NMe2)4] or a uranium benzyne complex, [Li][U(2,3-C6H3CH2NMe2)(2-C6H4CH2NMe2)3]. A DFT analysis suggests that the formation of a benzyne complex with U but not with Th is a kinetic and not thermodynamic effect.

  1. 基于NCBI开放接口的学科信息平台PubMed检索服务功能实现%Realization of subject plaform in PubMed based on NCBI

    Institute of Scientific and Technical Information of China (English)

    苏叶; 黄文

    2014-01-01

    As the world's largest network of biomedical bibliographic databases , PubMed plays an irreplaceable role in the field of biomedical research .The majority of biomedical researchers have accustomarily to used PubMed to find the lit-erature they need .Therefore , how to take advantage PubMed ,build and improve biomedical platforms is assuming new im-portance .NCBI provides open Application Programming Inteface ( API) of Web Service ,which is an effective combination of the two.%作为全球最大的网络生物医学文献数据库,美国PubMed在生物医学研究领域有着不可替代的作用。生物医学领域的科研人员已经习惯于利用PubMed查找所需要的信息资源。该文简要介绍了NCBI提供的Web Serv-ice接口功能,以及如何利用该接口在将PubMed检索服务内嵌到学科服务平台中,并将PubMed服务与图书馆的文献传递服务进行了尝试性的集成。

  2. SLIM: an alternative Web interface for MEDLINE/PubMed searches – a preliminary study

    Directory of Open Access Journals (Sweden)

    Ackerman Michael

    2005-12-01

    Full Text Available Abstract Background With the rapid growth of medical information and the pervasiveness of the Internet, online search and retrieval systems have become indispensable tools in medicine. The progress of Web technologies can provide expert searching capabilities to non-expert information seekers. The objective of the project is to create an alternative search interface for MEDLINE/PubMed searches using JavaScript slider bars. SLIM, or Slider Interface for MEDLINE/PubMed searches, was developed with PHP and JavaScript. Interactive slider bars in the search form controlled search parameters such as limits, filters and MeSH terminologies. Connections to PubMed were done using the Entrez Programming Utilities (E-Utilities. Custom scripts were created to mimic the automatic term mapping process of Entrez. Page generation times for both local and remote connections were recorded. Results Alpha testing by developers showed SLIM to be functionally stable. Page generation times to simulate loading times were recorded the first week of alpha and beta testing. Average page generation times for the index page, previews and searches were 2.94 milliseconds, 0.63 seconds and 3.84 seconds, respectively. Eighteen physicians from the US, Australia and the Philippines participated in the beta testing and provided feedback through an online survey. Most users found the search interface user-friendly and easy to use. Information on MeSH terms and the ability to instantly hide and display abstracts were identified as distinctive features. Conclusion SLIM can be an interactive time-saving tool for online medical literature research that improves user control and capability to instantly refine and refocus search strategies. With continued development and by integrating search limits, methodology filters, MeSH terms and levels of evidence, SLIM may be useful in the practice of evidence-based medicine.

  3. The trend of indexed papers in PubMed covering different aspects of self-immolation.

    Science.gov (United States)

    Rezaeian, Mohsen

    2014-01-01

    Self-immolation is a fatal and devastating method of committing suicide used around the world. The chief aim of the present article is to look at the trend of indexed papers in PubMed covering different aspects of self-immolation. PubMed search engine (http://www.ncbi.nlm.nih.gov) was searched by using six keywords i.e. "self-immolation", "self-inflicted burn", "self-burning", "self-incineration", "suicidal burns" and "suicide by burning". These keywords should appear either in the title or the abstract of the articles. The time frame was set as to retrieve papers expanding from early indexing time up to end of the year 2011. Based on the search strategy 132 papers were retrieved from these total numbers; 12 (9%) were categorized as review papers; 24 (18%) as case reports and the rest 96 (73%) were original studies. It seems that the number of papers increased during the years of investigations and the highest indexed papers i.e. 14 (10.6%) belonged to the year 2011. While most journals, published only one article the highest indexed papers i.e. 35 (26.5%) belonged to Burns. There was an increasing trend in the number of self-immolation articles indexed in PubMed since 1965. Three journals i.e. Burns, Journal of Burn Care and Rehabilitation and Journal of Forensic Sciences hosted for more than 37% of all those indexed articles. However, given the increasing trend of self-immolation still more studies are needed to shed light on the diverse aspects of this appalling human behavior.

  4. Incidencia de los atropellos sobre la fauna vertebrada en el Valle de El Paular. LIC "Cuenca del río Lozoya y Sierra Norte"

    Directory of Open Access Journals (Sweden)

    ESPINOSA, A., SERRANO, J.A., MONTORI, A.

    2012-01-01

    Full Text Available Las carreteras son uno de los agentes antrópicos de cambio más importantes. Son uno de los más relevantes agentes de fragmentación de hábitat, transformación de los sistemas naturales y actúan como un depredador inespecífico sobre la fauna. Varios estudios han demostrado que son la principal causa de mortalidad de anfibios, como es el caso del sapo común Bufo bufo (Linnaeus, 1758 en España. En un estudio previo realizado en la zona se puso de manifiesto que la mayor incidencia de los atropellos se producía sobre dos especies: Bufo calamita Laurenti, 1768 y Bufo bufo. Para analizar la situación actual y ampliar el área de estudio se seleccionaron 13 tramos de 1 km en las carreteras M-604 y M-611 localizadas en el LIC del Alto Lozoya (Sistema Central, Península Ibérica. Cada segmento prospectado se recorrió a pie en ambos sentidos tres veces al mes, durante dos años, desde marzo de 2009 (934 muestreos. Los transectos se caracterizaron considerando las variables: altitud de inicio y final, cobertura arbórea (para una franja de 20 m a ambos lados de la carretera, grado de humanización (muy bajo, bajo, medio y vegetación dominante. Las visitas a los tramos se realizaron con un intervalo promedio de 9 días, tiempo suficiente para que no existieran observaciones repetidas. Además, los ejemplares atropellados detectados eran retirados de la calzada cuando esto era posible. Se han registrado un total de 632 vertebrados muertos en la calzada que se distribuyen por grupos en 123 anfibios, 160 reptiles, 191 aves y 80 mamíferos de 4, 14, 26 y 12 especies distintas, respectivamente. No se han encontrado diferencias en el número de atropellos según el día de la semana, pero sí existen claras diferencias en la distribución de los atropellos a lo largo del año. Sólo dos variables ambientales muestran diferencias significativas según el grupo: el grado de humanización y el hábitat. Sin embargo, el test PostHoc de Bonferroni indica

  5. Proyecto de industria de cerveza artesanal con Brew Pub en Valladolid

    OpenAIRE

    Granado Sanz, Pablo

    2016-01-01

    El objetivo del proyecto es la construcción y puesta en marcha de una industria para la producción de cerveza artesanal en Valladolid. Además de la producción se incentivarán las ventas y publicidad de la marca mediante la instalación de un Brew Pub dentro de la misma, ofreciendo la cerveza producida en las mejores condiciones de calidad. La capacidad productiva para la que está diseñada la industria es de 225.000 litros de cerveza anuales. El envasado de la misma será en latas de aluminio...

  6. Proyecto de industria de cerveza artesanal con Brew Pub en Valladolid

    OpenAIRE

    Granado Sanz, Pablo

    2016-01-01

    El objetivo del proyecto es la construcción y puesta en marcha de una industria para la producción de cerveza artesanal en Valladolid. Además de la producción se incentivarán las ventas y publicidad de la marca mediante la instalación de un Brew Pub dentro de la misma, ofreciendo la cerveza producida en las mejores condiciones de calidad. La capacidad productiva para la que está diseñada la industria es de 225.000 litros de cerveza anuales. El envasado de la misma será en latas de aluminio...

  7. [Google and PubMed for physicians: how to find information without getting lost].

    Science.gov (United States)

    Muñoz Núñez, C F; Sendra Portero, F

    2013-06-01

    Searching on Internet looking for clinically relevant medical information, used as a clinical decision aid tool, for self-learning or for research, is currently a common practice in Radiology. This task has been strengthened by the technological environment where radiologists work with direct access to information sources from the Workstation. The aim of this paper is to review the basic features of information searching tools in order to understand their functions and to optimize medical information searching on Internet. Google, Google Scholar and PubMed are reviewed as models for that purpose.

  8. The interest of Romanian consumers in using QR codes in restaurants and pubs

    Directory of Open Access Journals (Sweden)

    Marius BĂLĂŞESCU

    2017-07-01

    Full Text Available The fast development of smartphone technology has created an opportunity to use QR code, considered a popular way of mobile tagging due to its ease of use. Various types of hospitality units, such as accommodations or restaurants and bars have found in QR codes an excellent marketing tool. This paper presents the results of a marketing research study conducted in Brasov city from Romania regarding the consumers’ interest in using QR codes in restaurants and pubs. The results show that mostly the young generation of consumers is aware of QR codes existence because they have smartphones and they are always interested in testing the latest technologies.

  9. Beyond PubMed: Searching the "Grey Literature" for Clinical Trial Results.

    Science.gov (United States)

    Citrome, Leslie

    2014-07-01

    Clinical trial results have been traditionally communicated through the publication of scholarly reports and reviews in biomedical journals. However, this dissemination of information can be delayed or incomplete, making it difficult to appraise new treatments, or in the case of missing data, evaluate older interventions. Going beyond the routine search of PubMed, it is possible to discover additional information in the "grey literature." Examples of the grey literature include clinical trial registries, patent databases, company and industrywide repositories, regulatory agency digital archives, abstracts of paper and poster presentations on meeting/congress websites, industry investor reports and press releases, and institutional and personal websites.

  10. Qatar biomedical and cancer publications in PubMed between 2000 and 2012.

    Science.gov (United States)

    Zeeneldin, Ahmed A; Taha, Fatma Mohamed

    2014-01-01

    The aim of this work was to analyse the past trends of biomedical and cancer publications from Qatar listed on PubMed for the years 2000-2012. These findings were then compared with the corresponding global number of publications. PubMed was searched for cancer publications, clinical trials, publications on humans or other species. Searching for "Qatar*" in the "Affiliation" field yielded the lowest number of publications; searching for "Qatar*" in the "Affiliation" or in "Title/Abstract" yielded a moderate number of results and searching for "Qatar*" in the "Affiliation" or "Title/Abstract" or "Text Word" fields yielded the highest number of publications. The annual percentage change (APC) from one year to the next was calculated for the population and each type of publication. Information on the population of Qatar was gathered from the website of Qatar Statistics Authority to determine the correlation of papers published per 1000 population. The number of publications retrieved from PubMed was not particularly different for each variation of search carried out. However, the most representative number of publications was retrieved upon searching for "Qatar*" in the "Affiliation" or in "Title/Abstract" fields. Between the years 2000 and 2012, the total number of biomedical publications from Qatar increased 24 times with an average APC of 33.4%, which was found to be more than the APC of the population in Qatar which averaged at 9%. The number of biomedical publications per 1000 population increased from 0.02 in 2000 to 0.15% in 2012. Most publications retrieved were humans studies and occasionally were for other animal species. Cancer publications in Qatar represented 16.9% of the total publications and the number of cancer publications per 1000 population increased from 0% in 2000 to 0.02% in 2012. Publications classified as clinical trials represented 4.6% of Qatar biomedical publications. Publication of cancer clinical trials were very rare (0.4%). Despite the

  11. The U-Box/ARM E3 ligase PUB13 regulates cell death, defense, and flowering time in Arabidopsis.

    Science.gov (United States)

    Li, Wei; Ahn, Il-Pyung; Ning, Yuese; Park, Chan-Ho; Zeng, Lirong; Whitehill, Justin G A; Lu, Haibin; Zhao, Qingzhen; Ding, Bo; Xie, Qi; Zhou, Jian-Min; Dai, Liangying; Wang, Guo-Liang

    2012-05-01

    The components in plant signal transduction pathways are intertwined and affect each other to coordinate plant growth, development, and defenses to stresses. The role of ubiquitination in connecting these pathways, particularly plant innate immunity and flowering, is largely unknown. Here, we report the dual roles for the Arabidopsis (Arabidopsis thaliana) Plant U-box protein13 (PUB13) in defense and flowering time control. In vitro ubiquitination assays indicated that PUB13 is an active E3 ubiquitin ligase and that the intact U-box domain is required for the E3 ligase activity. Disruption of the PUB13 gene by T-DNA insertion results in spontaneous cell death, the accumulation of hydrogen peroxide and salicylic acid (SA), and elevated resistance to biotrophic pathogens but increased susceptibility to necrotrophic pathogens. The cell death, hydrogen peroxide accumulation, and resistance to necrotrophic pathogens in pub13 are enhanced when plants are pretreated with high humidity. Importantly, pub13 also shows early flowering under middle- and long-day conditions, in which the expression of SUPPRESSOR OF OVEREXPRESSION OF CONSTANS1 and FLOWERING LOCUS T is induced while FLOWERING LOCUS C expression is suppressed. Finally, we found that two components involved in the SA-mediated signaling pathway, SID2 and PAD4, are required for the defense and flowering-time phenotypes caused by the loss of function of PUB13. Taken together, our data demonstrate that PUB13 acts as an important node connecting SA-dependent defense signaling and flowering time regulation in Arabidopsis.

  12. Benchmarking Ligand-Based Virtual High-Throughput Screening with the PubChem Database

    Directory of Open Access Journals (Sweden)

    Mariusz Butkiewicz

    2013-01-01

    Full Text Available With the rapidly increasing availability of High-Throughput Screening (HTS data in the public domain, such as the PubChem database, methods for ligand-based computer-aided drug discovery (LB-CADD have the potential to accelerate and reduce the cost of probe development and drug discovery efforts in academia. We assemble nine data sets from realistic HTS campaigns representing major families of drug target proteins for benchmarking LB-CADD methods. Each data set is public domain through PubChem and carefully collated through confirmation screens validating active compounds. These data sets provide the foundation for benchmarking a new cheminformatics framework BCL::ChemInfo, which is freely available for non-commercial use. Quantitative structure activity relationship (QSAR models are built using Artificial Neural Networks (ANNs, Support Vector Machines (SVMs, Decision Trees (DTs, and Kohonen networks (KNs. Problem-specific descriptor optimization protocols are assessed including Sequential Feature Forward Selection (SFFS and various information content measures. Measures of predictive power and confidence are evaluated through cross-validation, and a consensus prediction scheme is tested that combines orthogonal machine learning algorithms into a single predictor. Enrichments ranging from 15 to 101 for a TPR cutoff of 25% are observed.

  13. Geography of Africa biomedical publications: An analysis of 1996–2005 PubMed papers

    Directory of Open Access Journals (Sweden)

    Uthman Mubashir B

    2007-10-01

    Full Text Available Abstract Background Scientific publications play an important role in scientific process providing a key linkage between knowledge production and use. Scientific publishing activity worldwide over the past decades shows that most countries in Africa have low levels of publication. We sought to examine trends and contribution of different Africa subregions and individual countries as represented by the articles indexed by PubMed between 1996 and 2005. Results Research production in Africa is highly skewed; South Africa, Egypt, and Nigeria make up a striking 60% of the total number of articles indexed by PubMed between 1996 and 2005. When adjusted for population size smaller countries, such as The Gambia, Gabon and Botswana, were more productive than Nigeria and Kenya. The Gambia and Eritrea had better records when total production was adjusted for gross domestic product. The contribution of Africa to global research production was persistently low through the period studied. Conclusion In this study, we found that most populous and rich countries (such as South Africa, Egypt, and Nigeria have correspondingly higher research production; but smaller countries can be productive. We noted continuous increases and reassuring trends in the production of research articles from all African subregions during the period 1996 – 2005. However, contribution of Africa to global research production was limited.

  14. PubAngioGen: a database and knowledge for angiogenesis and related diseases.

    Science.gov (United States)

    Li, Peng; Liu, Yongrui; Wang, Huan; He, Yuan; Wang, Xue; He, Yundong; Lv, Fang; Chen, Huaqing; Pang, Xiufeng; Liu, Mingyao; Shi, Tieliu; Yi, Zhengfang

    2015-01-01

    Angiogenesis is the process of generating new blood vessels based on existing ones, which is involved in many diseases including cancers, cardiovascular diseases and diabetes mellitus. Recently, great efforts have been made to explore the mechanisms of angiogenesis in various diseases and many angiogenic factors have been discovered as therapeutic targets in anti- or pro-angiogenic drug development. However, the resulted information is sparsely distributed and no systematical summarization has been made. In order to integrate these related results and facilitate the researches for the community, we conducted manual text-mining from published literature and built a database named as PubAngioGen (http://www.megabionet.org/aspd/). Our online application displays a comprehensive network for exploring the connection between angiogenesis and diseases at multilevels including protein-protein interaction, drug-target, disease-gene and signaling pathways among various cells and animal models recorded through text-mining. To enlarge the scope of the PubAngioGen application, our database also links to other common resources including STRING, DrugBank and OMIM databases, which will facilitate understanding the underlying molecular mechanisms of angiogenesis and drug development in clinical therapy.

  15. GeneView: a comprehensive semantic search engine for PubMed.

    Science.gov (United States)

    Thomas, Philippe; Starlinger, Johannes; Vowinkel, Alexander; Arzt, Sebastian; Leser, Ulf

    2012-07-01

    Research results are primarily published in scientific literature and curation efforts cannot keep up with the rapid growth of published literature. The plethora of knowledge remains hidden in large text repositories like MEDLINE. Consequently, life scientists have to spend a great amount of time searching for specific information. The enormous ambiguity among most names of biomedical objects such as genes, chemicals and diseases often produces too large and unspecific search results. We present GeneView, a semantic search engine for biomedical knowledge. GeneView is built upon a comprehensively annotated version of PubMed abstracts and openly available PubMed Central full texts. This semi-structured representation of biomedical texts enables a number of features extending classical search engines. For instance, users may search for entities using unique database identifiers or they may rank documents by the number of specific mentions they contain. Annotation is performed by a multitude of state-of-the-art text-mining tools for recognizing mentions from 10 entity classes and for identifying protein-protein interactions. GeneView currently contains annotations for >194 million entities from 10 classes for ∼21 million citations with 271,000 full text bodies. GeneView can be searched at http://bc3.informatik.hu-berlin.de/.

  16. PubMed及其衍生数据库在医药领域的应用

    Institute of Scientific and Technical Information of China (English)

    吕霖

    2014-01-01

    本文对PubMed在医药领域的特色功能进行了介绍,对比了PubMed与其衍生数据库在功能方面的异同,探索了使用PubMed进行检索的基本策略,并通过案例分析了上述数据库在医药领域专利审查和研发查新中的特点和优势.

  17. Pattern and determinants of HIV research productivity in sub-Saharan Africa: bibliometric analysis of 1981 to 2009 PubMed papers

    Directory of Open Access Journals (Sweden)

    Uthman Olalekan A

    2010-03-01

    Full Text Available Abstract Background Several bibliometric studies have been published on AIDS. The findings obtained from these studies have provided a general picture of the history and growth of AIDS literature. However, factors related to variation in HIV research productivity in sub-Saharan Africa have not been examined. Therefore, this study aims to fill some of the gap in existing research to provide insights into factors associated with HIV research productivity in sub-Saharan Africa. Methods A bibliometric analysis regarding sub-Saharan Africa HIV/AIDS research was conducted in the PubMed database for the period of 1981 to 2009. The numbers of HIV research articles indexed in PubMed was used as surrogate for total HIV research productivity. Series of univariable and multivariable negative binomial regression models were used to explore factors associated with variation in HIV research productivity in sub-Saharan Africa. Results First authors from South Africa, Uganda and Kenya contributed almost half of the total number of HIV articles indexed in PubMed between 1981 and 2009. Uganda, Zimbabwe and Malawi had better records when the total production was adjusted for gross domestic product (GDP. Comoros, the Gambia and Guinea-Bissau were the most productive countries when the total products were normalized by number of people with HIV. There were strong positive and statistically significant correlation between countries number of indexed journal (Pearson correlation r = 0.77, p = .001, number of higher institutions (r = 0.60, p = .001, number of physicians (r = 0.83, p = .001 and absolute numbers of HIV articles. Conclusions HIV research productivity in Africa is highly skewed. To increase HIV research output, total expenditure on health (% of GDP, private expenditure on health, and adult literacy rate may be important factors to address.

  18. 借助 PubMed 实现医学期刊数字化推广的技术方法%Technologies and methods for digital marketing of medical journals on PubMed

    Institute of Scientific and Technical Information of China (English)

    万明; 许媛媛; 申学颖; 张莹; 张群

    2014-01-01

    分析PubMed对生物医学期刊发展的积极影响,特别是其Linkout功能在扩大期刊影响力方面的作用。以《生物医学与环境科学(英文版)》为例,介绍了利用Linkout功能实现从PubMed网站到期刊网站全文“无缝链接”的技术方法。%The effect of PubMed on the development of biomedical journals and the role of its Linkout function in extending the effect of journals were analyzed , followed by a description of the technologies and methods for the full-text seamless link of journal Websites and PubMed using its Linkout function with Biomedical and Environmental Sciences as an example .

  19. Synthesis, characterization, electrochemical investigation and antioxidant activities of a new hybrid cyclohexaphosphate: Cu1.5Li(C2H10N2)P6O18·7H2O

    Science.gov (United States)

    Sleymi, Samira; Lahbib, Karima; Rahmouni, Nihed; Rzaigui, Mohamed; Besbes-Hentati, Salma; Abid, Sonia

    2017-09-01

    A new organic-inorganic hybrid transition metal phosphate, Cu1.5Li(C2H10N2)P6O18·7H2O, has been prepared and characterized by X-ray diffraction, spectroscopy (infrared, Raman, diffuse reflectance and UV-Vis) and thermal analysis (TG). In addition, its electrochemical behaviors, as well as its antioxidant and antibacterial activities, have been investigated. Its structure is built up by the alternate linkages between copper and phosphate polyhedra, forming puckered layers with intersecting 12-membered rings, in which the ethylenediammonium cations reside. This compound is the first framework structure constructed from cyclohexaphosphates and three distinct copper cations. Cyclic voltammetry study in an acetonitrile solution reveals the facile anodic oxidation of its organic part on a platinum disk and a progressive growing of a thin film, though the repetitive cycling of potential. The title compound was tested for its in vitro antioxidant activities by 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2‧-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), Ferrous chelating ability (FIC) and Ferric Reducing Power (FRP) methods. The antioxidant activity of Cu1.5Li(C2H10N2)P6O18·7H2O was analyzed simultaneously with its antibacterial capacity against Escherichia coli, Salmonella typhimurium, Staphylococus aureus, Enterococcus feacium, Streptococcus agalactiae and Candida albicans. The tested compound showed significant antioxidant activities with low antibacterial properties.

  20. Crystal structure of 3-(3,4,5-tri-meth-oxy-phen-yl)-1,2,3,4-tetra-hydro-cyclo-penta[b]indole-2-carb-oxy-lic acid.

    Science.gov (United States)

    Fernandes, Daniara; Simoni, Deborah de Alencar; Rodrigues, Manoel T; Santos, Marilia S; Coelho, Fernando

    2015-06-01

    In the title compound, C21H21NO5, obtained from a Morita-Baylis-Hillman adduct, the hydrogenated five-membered ring adopts a shallow envelope conformation, with the C atom bearing the carb-oxy-lic acid substituent deviating by 0.237 (1) Å from the mean plane of the other four atoms (r.m.s. deviation = 0.007 Å). The dihedral angle between the fused ring system (all atoms; r.m.s. deviation = 0.057 Å) and the pendant trimeth-oxy benzene ring is 66.65 (3)°. The C atoms of the meta-meth-oxy groups lie close to the plane of the benzene ring [deviations = 0.052 (1) and -0.083 (1) Å], whereas the C atom of the para-meth-oxy group is significantly displaced [deviation = -1.289 (1) Å]. In the crystal, carb-oxy-lic acid inversion dimers generate R 2 (2)(8) loops. The dimers are connected by N-H⋯O hydrogen bonds, forming [011] chains. A C-H⋯O inter-action is also observed.

  1. GenBank数据库和PubMed数据库中序列数据信息检索比较%Comparison of sequential data retrieval results from GenBank and PubMed

    Institute of Scientific and Technical Information of China (English)

    李轶

    2009-01-01

    通过对GenBank数据库和PubMed数据库的数据来源、检索界面和检索结果等的对比分析,发现2个检索库检索的序列数据信息存在差别,GenBank数据库检索结果和检准率均高于PubMed数据库.

  2. 76 FR 39905 - Notice of Permit Applications Received Under the Antarctic Conservation Act of 1978 (Pub. L. 95-541)

    Science.gov (United States)

    2011-07-07

    ... 1978 (Pub. L. 95-541), as amended by the Antarctic Science, Tourism and Conservation Act of 1996, has... Wisconsin-Madison, 1525 Observatory Drive, Madison, WI 53706-1299. Activity for Which Permit Is...

  3. 77 FR 37445 - Notice of Permit Modification Received Under the Antarctic Conservation Act of 1978 (Pub. L. 95-541)

    Science.gov (United States)

    2012-06-21

    ... 1978 (Pub. L. 95-541), as amended by the Antarctic Science, Tourism and Conservation Act of 1996, has... assess the change in foraging behavior upon the arrival of whales in the penguin's foraging area...

  4. 76 FR 49797 - Notice of Permit Modification Received Under the Antarctic Conservation Act of 1978 (Pub. L. 95-541)

    Science.gov (United States)

    2011-08-11

    ... 1978 (Pub. L. 95-541), as ] amended by the Antarctic Science, Tourism and Conservation Act of 1996, has... substantial penguin and seabird populations which are relevant to the analysis of population trends. The ASPA...

  5. PubMed vs. HighWire Press: a head-to-head comparison of two medical literature search engines.

    Science.gov (United States)

    Vanhecke, Thomas E; Barnes, Michael A; Zimmerman, Janet; Shoichet, Sandor

    2007-09-01

    PubMed and HighWire Press are both useful medical literature search engines available for free to anyone on the internet. We measured retrieval accuracy, number of results generated, retrieval speed, features and search tools on HighWire Press and PubMed using the quick search features of each. We found that using HighWire Press resulted in a higher likelihood of retrieving the desired article and higher number of search results than the same search on PubMed. PubMed was faster than HighWire Press in delivering search results regardless of search settings. There are considerable differences in search features between these two search engines.

  6. 75 FR 62892 - Notice of Permit Applications Received Under the Antarctic Conservation Act of 1978 (Pub .L. 95-541)

    Science.gov (United States)

    2010-10-13

    ... 1978 (Pub. L. 95-541), as amended by the Antarctic Science, Tourism and Conservation Act of 1996, has... Modification Requested: The Foundation issued a permit (2009-015) to Ron Naveen on August 25,2008. The...

  7. 78 FR 76862 - Notice of Permit Applications Received Under the Antarctic Conservation Act of 1978 (Pub. L. 95-541)

    Science.gov (United States)

    2013-12-19

    ... the Antarctic Conservation Act of 1978 (Pub. L. 95-541), as amended by the Antarctic Science, Tourism.... Likewise, the sex of individual whales can be determined from genetic markers from the skin samples...

  8. 医学文献网上免费检索系统——PubMed

    Institute of Scientific and Technical Information of China (English)

    万丽娟; 万立野; 刘丹丹

    2009-01-01

    PubMed是由美国国立医学图书馆生物技术信息中心开发的一个数字化项目。本文就PubMed收录范围、检索方法、特征工具栏、检索常用按钮及其链接作如下介绍:

  9. Establishment of the Secure Channel between Broker Nodes in Pub/Sub System

    Institute of Scientific and Technical Information of China (English)

    ZHU Shuren

    2006-01-01

    The paper mainly discusses the integrity of the forwarded subscription message guaranteed by secure channel which encrypted in data communication by using data encryption standard (DES) algorithm and chaos code algorithm between broker nodes in the routing process of the content-based publish/subscribe system. It analyzes the security of the secure channel encrypted with data communication by DES algorithm and chaos code algorithm, and finds out the secure channel can be easily attacked by known plain text. Therefore, the paper proposes the improved algorithm of message encryption and authentication, combining encryption and the generation of the message authentication code together to finish scanning at one time, which enhances both the secure degree and running efficiency. This secure channel system has a certain reference value to the pub/sub system requiring highly communication security.

  10. Towards Automatic Extraction of Social Networks of Organizations in PubMed Abstracts

    CERN Document Server

    Jonnalagadda, Siddhartha; Gonzalez, Graciela

    2010-01-01

    Social Network Analysis (SNA) of organizations can attract great interest from government agencies and scientists for its ability to boost translational research and accelerate the process of converting research to care. For SNA of a particular disease area, we need to identify the key research groups in that area by mining the affiliation information from PubMed. This not only involves recognizing the organization names in the affiliation string, but also resolving ambiguities to identify the article with a unique organization. We present here a process of normalization that involves clustering based on local sequence alignment metrics and local learning based on finding connected components. We demonstrate the application of the method by analyzing organizations involved in angiogenensis treatment, and demonstrating the utility of the results for researchers in the pharmaceutical and biotechnology industries or national funding agencies.

  11. The PubChemQC project: A large chemical database from the first principle calculations

    Science.gov (United States)

    Maho, Nakata

    2015-12-01

    In this research, we have been constructing a large database of molecules by ab initio calculations. Currently, we have over 1.53 million entries of 6-31G* B3LYP optimized geometries and ten excited states by 6-31+G* TDDFT calculations. To calculate molecules, we only refer the InChI (International Chemical Identifier) representation of chemical formula by the International Union of Pure and Applied Chemistry (IUPAC), thus, no reference to experimental data. These results are open to public at http://pubchemqc.riken.jp/. The molecular data have been taken from the PubChem Project (http://pubchem.ncbi.nlm.nih.gov/) which is one of the largest in the world (approximately 63 million molecules are listed) and free (public domain) database. Our final goal is, using these data, to develop a molecular search engine or molecular expert system to find molecules which have desired properties.

  12. Structuring Chemical Space: Similarity-Based Characterization of the PubChem Database.

    Science.gov (United States)

    Cincilla, Giovanni; Thormann, Michael; Pons, Miquel

    2010-01-12

    The ensemble of conceivable molecules is referred to as the Chemical Space. In this article we describe a hierarchical version of the Affinity Propagation (AP) clustering algorithm and apply it to analyze the LINGO-based similarity matrix of a 500 000-molecule subset of the PubChem database, which contains more than 19 million compounds. The combination of two highly efficient methods, namely the AP clustering algorithm and LINGO-based molecular similarity calculations, allows the unbiased analysis of large databases. Hierarchical clustering generates a numerical diagonalization of the similarity matrix. The target-independent, intrinsic structure of the database , derived without any previous information on the physical or biological properties of the compounds, maps together molecules experimentally shown to bind the same biological target or to have similar physical properties.

  13. The PubChemQC Project: a large chemical database from the first principle calculations

    CERN Document Server

    Nakata, Maho

    2015-01-01

    In this research, we have been constructing a large database of molecules by {\\it ab initio} calculations. Currently, we have over 1.53 million entries of 6-31G* B3LYP optimized geometries and ten excited states by 6-31+G* TDDFT calculations. To calculate molecules, we only refer the InChI (International Chemical Identifier) representation of chemical formula by the International Union of Pure and Applied Chemistry (IUPAC), thus, no reference to experimental data. These results are open to public at http://pubchemqc.riken.jp/. The molecular data have been taken from the PubChem Project (http://pubchem.ncbi.nlm.nih.gov/) which is one of the largest in the world (approximately 63 million molecules are listed) and free (public domain) database. Our final goal is, using these data, to develop a molecular search engine or molecular expert system to find molecules which have desired properties.

  14. A Case Study on Sepsis Using PubMed and Deep Learning for Ontology Learning.

    Science.gov (United States)

    Arguello Casteleiro, Mercedes; Maseda Fernandez, Diego; Demetriou, George; Read, Warren; Fernandez Prieto, Maria Jesus; Des Diz, Julio; Nenadic, Goran; Keane, John; Stevens, Robert

    2017-01-01

    We investigate the application of distributional semantics models for facilitating unsupervised extraction of biomedical terms from unannotated corpora. Term extraction is used as the first step of an ontology learning process that aims to (semi-)automatic annotation of biomedical concepts and relations from more than 300K PubMed titles and abstracts. We experimented with both traditional distributional semantics methods such as Latent Semantic Analysis (LSA) and Latent Dirichlet Allocation (LDA) as well as the neural language models CBOW and Skip-gram from Deep Learning. The evaluation conducted concentrates on sepsis, a major life-threatening condition, and shows that Deep Learning models outperform LSA and LDA with much higher precision.

  15. Comparison of the time-to-indexing in PubMed between biomedical journals according to impact factor, discipline, and focus.

    Science.gov (United States)

    Irwin, Adriane N; Rackham, Daniel

    Practicing evidence-based medicine requires health care professionals to efficiently retrieve relevant and current literature. The purpose of this study was to compare the time interval between PubMed entry and indexing with Medical Subject Headings (MeSH) between biomedical journals with varying impact factors, focus areas, and health care discipline representation. This was a cross-sectional study of articles entered into PubMed database between January 1 and December 31, 2012. The primary endpoint was the number of days between PubMed entry and indexing with MeSH terms. A total of 7906 articles were reviewed across 18 journals. In the first comparison, the time-to-indexing was 177 ± 100 days, 111 ± 69 days, and 23 ± 40 days for articles published in journals with impact factors of 2.0-2.5, 4.5-6.5, and >25, respectively (P ≤ 0.001). In the second comparison, the time-to-indexing was 111 ± 69 days for general medicine versus 170 ± 74 days for specialty journals (P ≤ 0.001). In the third comparison, the overall time-to-indexing was 177 ± 100 days, 234 ± 107 days, and 163 ± 58 days for medicine, nursing, and pharmacy journals, respectively (P ≤ 0.001). Study results identified a significant delay between entry of articles into the PubMed database and time-to-indexing with MeSH terms across journals of varying impact factor, discipline, and focus. Results suggest that there may be factors that influence the priority by which articles are indexed with MeSH terms. Future research should focus on determining those journal characteristics and any impact of this delay on clinical practice. Copyright © 2016 Elsevier Inc. All rights reserved.

  16. PubMed search filters for the study of putative outdoor air pollution determinants of disease.

    Science.gov (United States)

    Curti, Stefania; Gori, Davide; Di Gregori, Valentina; Farioli, Andrea; Baldasseroni, Alberto; Fantini, Maria Pia; Christiani, David C; Violante, Francesco S; Mattioli, Stefano

    2016-12-21

    Several PubMed search filters have been developed in contexts other than environmental. We aimed at identifying efficient PubMed search filters for the study of environmental determinants of diseases related to outdoor air pollution. We compiled a list of Medical Subject Headings (MeSH) and non-MeSH terms seeming pertinent to outdoor air pollutants exposure as determinants of diseases in the general population. We estimated proportions of potentially pertinent articles to formulate two filters (one 'more specific', one 'more sensitive'). Their overall performance was evaluated as compared with our gold standard derived from systematic reviews on diseases potentially related to outdoor air pollution. We tested these filters in the study of three diseases potentially associated with outdoor air pollution and calculated the number of needed to read (NNR) abstracts to identify one potentially pertinent article in the context of these diseases. Last searches were run in January 2016. The 'more specific' filter was based on the combination of terms that yielded a threshold of potentially pertinent articles ≥40%. The 'more sensitive' filter was based on the combination of all search terms under study. When compared with the gold standard, the 'more specific' filter reported the highest specificity (67.4%; with a sensitivity of 82.5%), while the 'more sensitive' one reported the highest sensitivity (98.5%; with a specificity of 47.9%). The NNR to find one potentially pertinent article was 1.9 for the 'more specific' filter and 3.3 for the 'more sensitive' one. The proposed search filters could help healthcare professionals investigate environmental determinants of medical conditions that could be potentially related to outdoor air pollution. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  17. PubMed’s Native Interface Remains the Best Tool for Systematic Searching of its Biomedical Citations

    Directory of Open Access Journals (Sweden)

    Ann Glusker

    2017-06-01

    Full Text Available A Review of: Wildgaard, L. E., & Lund, H. (2016. Advancing PubMed? A comparison of third-party PubMed/Medline tools. Library Hi Tech, 34 (4, 669-684. http://dx.doi.org/doi: 10.1108/LHT-06-2016-0066 Abstract Objective – To compare the functionality of third-party PubMed tools for searching biomedical citations in PubMed, in the specific context of systematic searching. Design – Comparative analysis of software functionality. Setting – Online, freely accessible search software. Subjects – Sixteen third-party tools for searching and managing the full range of PubMed citations (tools which focused on specific disciplines were not included. Methods – Tools for analysis were identified in two ways; those discussed in two published articles were used, and a supplementary PubMed search was performed. The initial list of 76 possibilities was assessed for study inclusion on 4 criteria: covering the entire range of PubMed content; being freely available; not limiting to a particular bio-medical discipline; and incorporating online PubMed/MEDLINE content. After assessment, 16 tools were chosen for further analysis (the authors provide a list and description of the tools in their Table I. Each was examined in relation to 11 crucial operational aspects. Result sets were tested against a control (a literature search result set on a particular clinical question which was determined by physicians to yield relevant results, details of which are provided by the authors in an online appendix. Main Results – The 11 identified aspects related to tool functionality were examined for each tool selected, with results grouped into three sets of factors: 1 supporting the search (field codes, filters, limits and Boolean operators; 2 managing the search (output, related articles, links to articles, number of results, exporting; and 3 documenting the search (saving the search and search history. In some cases, the tests had to be adjusted to accommodate the tool

  18. The Application Characteristics of Biomedical Literature Retrieval Tools Based on PubMed Data Sources%基于PubMed数据源的生物医学文献检索工具应用特点

    Institute of Scientific and Technical Information of China (English)

    闫微; 张亚莉; 邓小茹

    2012-01-01

    The paper compares the application characteristics of 12 biomedical literature retrieval tools based on PubMed data sources in aspects of retrieval methods and retrieval results processing.The innovations are summarized from three aspects,namely,improving the retrieval interface,ranking results by relevance and results clustering.The improvement of Entrez/PubMed is also pointed out.%从检索方式和检索结果处理两个方面比较12种基于PubMed数据源的医学文献检索工具的应用特点,并从改变检索界面、相关性排序和检索结果聚类3个方面总结这类检索工具的创新之处,指出Entrez/PubMed自身新的改进。

  19. Enhancing search efficiency by means of a search filter for finding all studies on animal experimentation in PubMed.

    Science.gov (United States)

    Hooijmans, Carlijn R; Tillema, Alice; Leenaars, Marlies; Ritskes-Hoitinga, Merel

    2010-07-01

    Collecting and analysing all available literature before starting an animal experiment is important and it is indispensable when writing a systematic review (SR) of animal research. Writing such review prevents unnecessary duplication of animal studies and thus unnecessary animal use (Reduction). One of the factors currently impeding the production of 'high-quality' SRs in laboratory animal science is the fact that searching for all available literature concerning animal experimentation is rather difficult. In order to diminish these difficulties, we developed a search filter for PubMed to detect all publications concerning animal studies. This filter was compared with the method most frequently used, the PubMed Limit: Animals, and validated further by performing two PubMed topic searches. Our filter performs much better than the PubMed limit: it retrieves, on average, 7% more records. Other important advantages of our filter are that it also finds the most recent records and that it is easy to use. All in all, by using our search filter in PubMed, all available literature concerning animal studies on a specific topic can easily be found and assessed, which will help in increasing the scientific quality and thereby the ethical validity of animal experiments.

  20. Crystal structure of 4-{[(2,4-di­hydroxy­benzyl­idene)amino]­meth­yl}cyclo­hexane­carb­oxy­lic acid

    Science.gov (United States)

    Danish, Muhammad; Akbar, Saba; Tahir, Muhammad Nawaz; Butt, Rabia Ayub; Ashfaq, Muhammad

    2015-01-01

    In the title compound, C15H19NO4, the cyclo­hexyl ring adopts a chair conformation with both exocyclic C—C bonds in equatorial orientations. The dihedral angle between the basal plane of cyclo­hexyl ring and the 2,4-di­hydroxy­benzaldehyde moiety is 84.13 (13)°. An intra­molecular O—H⋯N hydrogen bonds closes an S(6) ring. In the crystal, Oc—H⋯Op (c = carb­oxy­lic acid, p = phenol) hydrogen bonds link the mol­ecules into [100] C(13) chains whereas an Op—H⋯Oc hydrogen bond generates [101] C(15) chains. Together, these bonds generate (010) sheets incorporating R 2 2(20) loops. Weak C—H⋯O and C—H⋯π inter­actions also occur. PMID:26870569

  1. Genetic Testing: MedlinePlus Health Topic

    Science.gov (United States)

    ... Glitches (National Institutes of Health) Genetic Mapping (National Human Genome Research Institute) Also in Spanish Clinical Trials ClinicalTrials.gov: Genetic Testing (National Institutes of Health) Journal Articles References and abstracts from MEDLINE/PubMed (National ...

  2. GoPubMed与Web of Knowledge分析工具Analyze Results的比较研究%Comparison of GoPubMed and Analyze Results, an analysis tool of Web of Knowledge

    Institute of Scientific and Technical Information of China (English)

    张玢; 许培扬; 王敏; 马明; 栗文靖

    2009-01-01

    GoPubMed是基于本体论的生物医学文献分析工具,它可以对检索到的PubMed文献进行全方位的统计分析,Web of Knowlegde平台的Analyze Results分析功能也可对检索结果进行统计分析.对这2种文献分析工具特点进行对比分析.

  3. Predicting adverse drug reactions using publicly available PubChem BioAssay data.

    Science.gov (United States)

    Pouliot, Y; Chiang, A P; Butte, A J

    2011-07-01

    Adverse drug reactions (ADRs) can have severe consequences, and therefore the ability to predict ADRs prior to market introduction of a drug is desirable. Computational approaches applied to preclinical data could be one way to inform drug labeling and marketing with respect to potential ADRs. Based on the premise that some of the molecular actors of ADRs involve interactions that are detectable in large, and increasingly public, compound screening campaigns, we generated logistic regression models that correlate postmarketing ADRs with screening data from the PubChem BioAssay database. These models analyze ADRs at the level of organ systems, using the system organ classes (SOCs). Of the 19 SOCs under consideration, nine were found to be significantly correlated with preclinical screening data. With regard to six of the eight established drugs for which we could retropredict SOC-specific ADRs, prior knowledge was found that supports these predictions. We conclude this paper by predicting that SOC-specific ADRs will be associated with three unapproved or recently introduced drugs.

  4. Sex Disparity in Food Allergy: Evidence from the PubMed Database

    Directory of Open Access Journals (Sweden)

    Caleb Kelly

    2009-01-01

    Full Text Available Food allergies are potentially fatal immune-mediated disorders that are growing globally. The relationship between sex and food allergy remains incompletely understood. Here we tested the hypothesis that, should sex influence the clinical response to food allergens, this would be reflected by a sex disparity in published studies of food allergy. We performed a systematic search of the PubMed literature for IgE-mediated allergy to 11 allergenic foods of international regulatory importance. No date restriction was used and only articles in English were considered. Of the 4744 articles retrieved, 591 met the inclusion criteria representing 17528 subjects with food allergies. Whereas among children with food allergies, 64.35% were males and 35.65% were females (male/female ratio, 1.80, among adults 34.82% were males and 65.18% were females (male/female ratio, 0.53. Consequently, these data argue that there is need for further investigation to define the role of sex in the pathogenesis of food allergy.

  5. Cupping Therapy May be Harmful for Eczema: A PubMed Search.

    Science.gov (United States)

    Hon, Kam Lun E; Luk, David Chi Kong; Leong, Kin Fon; Leung, Alexander K C

    2013-01-01

    Eczema is a common childhood atopic condition and treatment is with emollients, topical corticosteroids, and avoidance of possible triggers. S. aureus colonization is a common complication. As there is no immediate cure, many parents seek alternative therapies that claim unproven therapeutic efficacy. We report a girl with long history of treatment noncompliance. After practicing a long period of dietary avoidance and supplementation, the grandparents took her to an alternative medicine practitioner. Following cupping therapy and acupuncture, the child developed blistering and oozing over her back the next day, which rapidly evolved to two large irregular-edge deep ulcers. She was treated with intravenous antibiotics and received multidisciplinary supportive intervention. Using search words of  "cupping," "eczema," and "atopic dermatitis," only two reports were found on PubMed. Therapeutic efficacy was claimed but not scientifically documented in these reports. Childhood eczema is an eminently treatable atopic disease. Extreme alternative therapy seems not to be efficacious and may even be associated with serious undesirable sequelae. Physicians should be aware of various alternative treatment modalities and be prepared to offer evidence-based advice to the patients with eczema and their families.

  6. Cupping Therapy May be Harmful for Eczema: A PubMed Search

    Directory of Open Access Journals (Sweden)

    Kam Lun E. Hon

    2013-01-01

    Full Text Available Eczema is a common childhood atopic condition and treatment is with emollients, topical corticosteroids, and avoidance of possible triggers. S. aureus colonization is a common complication. As there is no immediate cure, many parents seek alternative therapies that claim unproven therapeutic efficacy. We report a girl with long history of treatment noncompliance. After practicing a long period of dietary avoidance and supplementation, the grandparents took her to an alternative medicine practitioner. Following cupping therapy and acupuncture, the child developed blistering and oozing over her back the next day, which rapidly evolved to two large irregular-edge deep ulcers. She was treated with intravenous antibiotics and received multidisciplinary supportive intervention. Using search words of  “cupping,” “eczema,” and “atopic dermatitis,” only two reports were found on PubMed. Therapeutic efficacy was claimed but not scientifically documented in these reports. Childhood eczema is an eminently treatable atopic disease. Extreme alternative therapy seems not to be efficacious and may even be associated with serious undesirable sequelae. Physicians should be aware of various alternative treatment modalities and be prepared to offer evidence-based advice to the patients with eczema and their families.

  7. Kidney transplantation search filters for PubMed, Ovid Medline, and Embase.

    Science.gov (United States)

    Lee, Christopher W C; Iansavichus, Arthur V; Haynes, R Brian; Shariff, Salimah Z; Wilczynski, Nancy; McKibbon, Ann; Rehman, Faisal; Garg, Amit X

    2012-03-15

    Clinicians commonly search bibliographic databases such as Medline to find sound evidence to guide patient care. Unfortunately, this can be a frustrating experience because database searches often miss relevant articles. We addressed this problem for transplant professionals by developing kidney transplantation search filters for use in Medline through PubMed and Ovid Technologies, and Embase. We began by reading the full-text versions of 22,992 articles from 39 journals published across 5 years. These articles were labeled relevant to kidney transplantation or not forming our "gold standard." We then developed close to five million kidney transplantation filters using different terms and their combinations. Afterward, these filters were applied to development and validation subsets of the articles to determine their accuracy and reliability in identifying articles with kidney transplantation content. The final kidney transplantation filters used multiple terms in combination. The best performing filters achieved 97.5% sensitivity (95% confidence interval, 96.4%-98.5%), and 98.0% specificity (95% confidence interval, 97.8%-98.3%). Similar high performance was achieved for filters developed for Ovid Medline and Embase. Proof-of-concept searches confirmed more relevant articles are retrieved using these filters. These kidney transplantation filters can now be used in Medline and Embase databases to improve clinician searching.

  8. Stochastic Gradient Descent and the Prediction of MeSH for PubMed Records.

    Science.gov (United States)

    Wilbur, W John; Kim, Won

    2014-01-01

    Stochastic Gradient Descent (SGD) has gained popularity for solving large scale supervised machine learning problems. It provides a rapid method for minimizing a number of loss functions and is applicable to Support Vector Machine (SVM) and Logistic optimizations. However SGD does not provide a convenient stopping criterion. Generally an optimal number of iterations over the data may be determined using held out data. Here we compare stopping predictions based on held out data with simply stopping at a fixed number of iterations and show that the latter works as well as the former for a number of commonly studied text classification problems. In particular fixed stopping works well for MeSH(®) predictions on PubMed(®) records. We also surveyed the published algorithms for SVM learning on large data sets, and chose three for comparison: PROBE, SVMperf, and Liblinear and compared them with SGD with a fixed number of iterations. We find SGD with a fixed number of iterations performs as well as these alternative methods and is much faster to compute. As an application we made SGD-SVM predictions for all MeSH terms and used the Pool Adjacent Violators (PAV) algorithm to convert these predictions to probabilities. Such probabilistic predictions lead to ranked MeSH term predictions superior to previously published results on two test sets.

  9. Retrieval comparison of EndNote to search MEDLINE (Ovid and PubMed) versus searching them directly.

    Science.gov (United States)

    Gall, Carole; Brahmi, Frances A

    2004-01-01

    Using EndNote version 7.0, the authors tested the search capabilities of the EndNote search engine for retrieving citations from MEDLINE for importation into EndNote, a citation management software package. Ovid MEDLINE and PubMed were selected for the comparison. Several searches were performed on Ovid MEDLINE and PubMed using EndNote as the search engine, and the same searches were run on both Ovid and PubMed directly. Findings indicate that it is preferable to search MEDLINE directly rather than using EndNote. The publishers of EndNote do warn its users about the limitations of their product as a search engine when searching external databases. In this article, the limitations of EndNote as a search engine for searching MEDLINE were explored as related to MeSH, non-MeSH, citation verification, and author searching.

  10. 网上PubMed新检索系统介绍及与旧系统的比较

    Institute of Scientific and Technical Information of China (English)

    任效娥

    2000-01-01

    @@ PubMed自1997年6月在网上开通免费读者服务以来,(其网址为:http://www.ncbi.nim.gpv/PubMed),因用户界面友好、检索途径多样、功能齐全、链接点多而深受读者欢迎,已成为当前世界范围使用最广泛的免费MEDLINE网站,并于1999年又推出了新检索系统界面.

  11. U-box E3 ubiquitin ligase PUB17 acts in the nucleus to promote specific immune pathways triggered by Phytophthora infestans.

    Science.gov (United States)

    He, Qin; McLellan, Hazel; Boevink, Petra C; Sadanandom, Ari; Xie, Conghua; Birch, Paul R J; Tian, Zhendong

    2015-06-01

    Ubiquitination regulates many processes in plants, including immunity. The E3 ubiquitin ligase PUB17 is a positive regulator of programmed cell death (PCD) triggered by resistance proteins CF4/9 in tomato. Its role in immunity to the potato late blight pathogen, Phytophthora infestans, was investigated here. Silencing StPUB17 in potato by RNAi and NbPUB17 in Nicotiana benthamiana by virus-induced gene silencing (VIGS) each enhanced P. infestans leaf colonization. PAMP-triggered immunity (PTI) transcriptional responses activated by flg22, and CF4/Avr4-mediated PCD were attenuated by silencing PUB17. However, silencing PUB17 did not compromise PCD triggered by P. infestans PAMP INF1, or co-expression of R3a/AVR3a, demonstrating that not all PTI- and PCD-associated responses require PUB17. PUB17 localizes to the plant nucleus and especially in the nucleolus. Transient over-expression of a dominant-negative StPUB17(V314I,V316I) mutant, which retained nucleolar localization, suppressed CF4-mediated cell death and enhanced P. infestans colonization. Exclusion of the StPUB17(V314I,V316I) mutant from the nucleus abolished its dominant-negative activity, demonstrating that StPUB17 functions in the nucleus. PUB17 is a positive regulator of immunity to late blight that acts in the nucleus to promote specific PTI and PCD pathways.

  12. Microtask crowdsourcing for disease mention annotation in PubMed abstracts.

    Science.gov (United States)

    Good, Benjamin M; Nanis, Max; Wu, Chunlei; Su, Andrew I

    2015-01-01

    Identifying concepts and relationships in biomedical text enables knowledge to be applied in computational analyses. Many biological natural language processing (BioNLP) projects attempt to address this challenge, but the state of the art still leaves much room for improvement. Progress in BioNLP research depends on large, annotated corpora for evaluating information extraction systems and training machine learning models. Traditionally, such corpora are created by small numbers of expert annotators often working over extended periods of time. Recent studies have shown that workers on microtask crowdsourcing platforms such as Amazon's Mechanical Turk (AMT) can, in aggregate, generate high-quality annotations of biomedical text. Here, we investigated the use of the AMT in capturing disease mentions in PubMed abstracts. We used the NCBI Disease corpus as a gold standard for refining and benchmarking our crowdsourcing protocol. After several iterations, we arrived at a protocol that reproduced the annotations of the 593 documents in the 'training set' of this gold standard with an overall F measure of 0.872 (precision 0.862, recall 0.883). The output can also be tuned to optimize for precision (max = 0.984 when recall = 0.269) or recall (max = 0.980 when precision = 0.436). Each document was completed by 15 workers, and their annotations were merged based on a simple voting method. In total 145 workers combined to complete all 593 documents in the span of 9 days at a cost of $.066 per abstract per worker. The quality of the annotations, as judged with the F measure, increases with the number of workers assigned to each task; however minimal performance gains were observed beyond 8 workers per task. These results add further evidence that microtask crowdsourcing can be a valuable tool for generating well-annotated corpora in BioNLP. Data produced for this analysis are available at http://figshare.com/articles/Disease_Mention_Annotation_with_Mechanical_Turk/1126402.

  13. Semi-automatic semantic annotation of PubMed queries: a study on quality, efficiency, satisfaction.

    Science.gov (United States)

    Névéol, Aurélie; Islamaj Doğan, Rezarta; Lu, Zhiyong

    2011-04-01

    Information processing algorithms require significant amounts of annotated data for training and testing. The availability of such data is often hindered by the complexity and high cost of production. In this paper, we investigate the benefits of a state-of-the-art tool to help with the semantic annotation of a large set of biomedical queries. Seven annotators were recruited to annotate a set of 10,000 PubMed® queries with 16 biomedical and bibliographic categories. About half of the queries were annotated from scratch, while the other half were automatically pre-annotated and manually corrected. The impact of the automatic pre-annotations was assessed on several aspects of the task: time, number of actions, annotator satisfaction, inter-annotator agreement, quality and number of the resulting annotations. The analysis of annotation results showed that the number of required hand annotations is 28.9% less when using pre-annotated results from automatic tools. As a result, the overall annotation time was substantially lower when pre-annotations were used, while inter-annotator agreement was significantly higher. In addition, there was no statistically significant difference in the semantic distribution or number of annotations produced when pre-annotations were used. The annotated query corpus is freely available to the research community. This study shows that automatic pre-annotations are found helpful by most annotators. Our experience suggests using an automatic tool to assist large-scale manual annotation projects. This helps speed-up the annotation time and improve annotation consistency while maintaining high quality of the final annotations.

  14. Use of positive and negative words in scientific PubMed abstracts between 1974 and 2014 : retrospective analysis

    NARCIS (Netherlands)

    Vinkers, Christiaan H; Tijdink, Joeri K; Otte, Willem M

    2015-01-01

    OBJECTIVE: To investigate whether language used in science abstracts can skew towards the use of strikingly positive and negative words over time. DESIGN: Retrospective analysis of all scientific abstracts in PubMed between 1974 and 2014. METHODS: The yearly frequencies of positive, negative, and ne

  15. RNA binding protein Pub1p regulates glycerol production and stress tolerance by controlling Gpd1p activity during winemaking.

    Science.gov (United States)

    Orozco, Helena; Sepúlveda, Ana; Picazo, Cecilia; Matallana, Emilia; Aranda, Agustín

    2016-06-01

    Glycerol is a key yeast metabolite in winemaking because it contributes to improve the organoleptic properties of wine. It is also a cellular protective molecule that enhances the tolerance of yeasts to osmotic stress and promotes longevity. Thus, its production increases by genetic manipulation, which is of biotechnological and basic interest. Glycerol is produced by diverting glycolytic glyceraldehyde-3-phosphate through the action of glycerol-3-phosphate dehydrogenase (coded by genes GPD1 and GPD2). Here, we demonstrate that RNA-binding protein Pub1p regulates glycerol production by controlling Gpd1p activity. Its deletion does not alter GPD1 mRNA levels, but protein levels and enzymatic activity increase, which explains the higher intracellular glycerol concentration and greater tolerance to osmotic stress of the pub1∆ mutant. PUB1 deletion also enhances the activity of nicotinamidase, a longevity-promoting enzyme. Both enzymatic activities are partially located in peroxisomes, and we detected peroxisome formation during wine fermentation. The role of Pub1p in life span control depends on nutrient conditions and is related with the TOR pathway, and a major connection between RNA metabolism and the nutrient signaling response is established.

  16. 78 FR 58568 - Notice of Permit Applications Received Under the Antarctic Conservation Act of 1978 (Pub. L. 95-541)

    Science.gov (United States)

    2013-09-24

    ... requiring special protection. The regulations establish such a permit system to designate Antarctic... Notice of Permit Applications Received Under the Antarctic Conservation Act of 1978 (Pub. L. 95-541) AGENCY: National Science Foundation. ACTION: Notice of Permit Applications Received under the...

  17. 75 FR 53723 - Notice of Permit Applications Received Under the Antarctic Conservation Act of 1978 (Pub. L. 95-541)

    Science.gov (United States)

    2010-09-01

    ... requiring special protection. The regulations establish such a permit system to designate Antarctic... Antarctic Conservation Act of 1978 (Pub. L. 95-541) AGENCY: National Science Foundation. ACTION: Notice of Permit Applications Received under the Antarctic Conservation Act of 1978, Public Law 95-541....

  18. 78 FR 53789 - Notice of Permit Applications Received Under the Antarctic Conservation Act of 1978 (Pub. L. 95-541)

    Science.gov (United States)

    2013-08-30

    ... requiring special protection. The regulations establish such a permit system to designate Antarctic... Notice of Permit Applications Received Under the Antarctic Conservation Act of 1978 (Pub. L. 95-541) AGENCY: National Science Foundation. ] ACTION: Notice of Permit Applications Received Under the...

  19. 76 FR 30397 - Notice of Permit Applications Received Under the Antarctic Conservation Act of 1978 (Pub. L. 95-541)

    Science.gov (United States)

    2011-05-25

    ... requiring special protection. The regulations establish such a permit system to designate Antarctic... Antarctic Conservation Act of 1978 (Pub. L. 95-541) AGENCY: National Science Foundation. ACTION: Notice of Permit Modification Received under the Antarctic Conservation Act of 1978, Public Law 95-541....

  20. 77 FR 31044 - Notice of Permit Applications Received Under the Antarctic Conservation Act of 1978 (Pub. L. 95-541)

    Science.gov (United States)

    2012-05-24

    ... requiring special protection. The regulations establish such a permit system to designate Antarctic... Antarctic Conservation Act of 1978 (Pub. L. 95-541) AGENCY: National Science Foundation. ACTION: Notice of Permit Applications Received Under the Antarctic Conservation Act of 1978, Public Law 95-541....

  1. 78 FR 52804 - Notice of Permit Applications Received Under the Antarctic Conservation Act of 1978 (Pub. L. 95-541)

    Science.gov (United States)

    2013-08-26

    ... requiring special protection. The regulations establish such a permit system to designate Antarctic... Notice of Permit Applications Received Under the Antarctic Conservation Act of 1978 (Pub. L. 95-541) AGENCY: National Science Foundation. ACTION: Notice of permit applications received under the...

  2. 78 FR 54492 - Notice of Permit Applications Received Under the Antarctic Conservation Act of 1978 (Pub. L. 95-541)

    Science.gov (United States)

    2013-09-04

    ... special protection. The regulations establish such a permit system to designate Antarctic Specially... Notice of Permit Applications Received Under the Antarctic Conservation Act of 1978 (Pub. L. 95-541) AGENCY: National Science Foundation. ACTION: Notice of Permit Applications Received under the...

  3. 78 FR 54685 - Notice of Permit Applications Received Under the Antarctic Conservation Act of 1978 (Pub. L. 95-541)

    Science.gov (United States)

    2013-09-05

    ... requiring special protection. The regulations establish such a permit system to designate Antarctic... Notice of Permit Applications Received Under the Antarctic Conservation Act of 1978 (Pub. L. 95-541) AGENCY: National Science Foundation. ACTION: Notice of Permit Applications Received under the...

  4. 78 FR 52218 - Notice of permit applications received under the Antarctic Conservation Act of 1978 (Pub. L. 95-541)

    Science.gov (United States)

    2013-08-22

    ... requiring special protection. The regulations establish such a permit system to ] designate Antarctic... Notice of permit applications received under the Antarctic Conservation Act of 1978 (Pub. L. 95-541) AGENCY: National Science Foundation. ACTION: Notice of permit applications received under the...

  5. 77 FR 53236 - Notice of Permit Applications Received Under the Antarctic Conservation Act of 1978 (Pub. L. 95-541)

    Science.gov (United States)

    2012-08-31

    ... the Antarctic Treaty System to ensure consistency with recently adopted plans, policies and guidelines... Notice of Permit Applications Received Under the Antarctic Conservation Act of 1978 (Pub. L. 95-541) AGENCY: National Science Foundation. ACTION: Notice of Permit Applications Received under the...

  6. 78 FR 48201 - Notice of Permit Applications Received Under the Antarctic Conservation Act of 1978 (Pub. L. 95-541)

    Science.gov (United States)

    2013-08-07

    ... sites at various sub-Antarctic (within geographic coverage area of the Antarctic Treaty) and Antarctic... Antarctic Conservation Act of 1978 (Pub. L. 95-541) AGENCY: National Science Foundation. ACTION: Notice of Permit Applications Received under the Antarctic Conservation Act of 1978, Public Law 95-541....

  7. 78 FR 69709 - Notice of Permit Modification Received Under the Antarctic Conservation Act of 1978 (Pub. L. 95-541)

    Science.gov (United States)

    2013-11-20

    ... Protection to the Antarctic Treaty and would be disposed of properly Now the applicant proposes a... Notice of Permit Modification Received Under the Antarctic Conservation Act of 1978 (Pub. L. 95-541... Antarctic Conservation Act of 1978, Public Law 95-541. SUMMARY: The National Science Foundation (NSF)...

  8. Identification of risk conditions for the development of adrenal disorders: how optimized PubMed search strategies makes the difference.

    Science.gov (United States)

    Guaraldi, Federica; Parasiliti-Caprino, Mirko; Goggi, Riccardo; Beccuti, Guglielmo; Grottoli, Silvia; Arvat, Emanuela; Ghizzoni, Lucia; Ghigo, Ezio; Giordano, Roberta; Gori, Davide

    2014-12-01

    The exponential growth of scientific literature available through electronic databases (namely PubMed) has increased the chance of finding interesting articles. At the same time, search has become more complicated, time consuming, and at risk of missing important information. Therefore, optimized strategies have to be adopted to maximize searching impact. The aim of this study was to formulate efficient strings to search PubMed for etiologic associations between adrenal disorders (ADs) and other conditions. A comprehensive list of terms identifying endogenous conditions primarily affecting adrenals was compiled. An ad hoc analysis was performed to find the best way to express each term in order to find the highest number of potentially pertinent articles in PubMed. A predefined number of retrieved abstracts were read to assess their association with ADs' etiology. A more sensitive (providing the largest literature coverage) and a more specific (including only those terms retrieving >40 % of potentially pertinent articles) string were formulated. Various researches were performed to assess strings' ability to identify articles of interest in comparison with non-optimized literature searches. We formulated optimized, ready applicable tools for the identification of the literature assessing etiologic associations in the field of ADs using PubMed, and demonstrated the advantages deriving from their application. Detailed description of the methodological process is also provided, so that this work can easily be translated to other fields of practice.

  9. Shifting Sands: Science Researchers on Google Scholar, Web of Science, and PubMed, with Implications for Library Collections Budgets

    Science.gov (United States)

    Hightower, Christy; Caldwell, Christy

    2010-01-01

    Science researchers at the University of California Santa Cruz were surveyed about their article database use and preferences in order to inform collection budget choices. Web of Science was the single most used database, selected by 41.6%. Statistically there was no difference between PubMed (21.5%) and Google Scholar (18.7%) as the second most…

  10. How to improve your PubMed/MEDLINE searches: 3. advanced searching, MeSH and My NCBI.

    Science.gov (United States)

    Fatehi, Farhad; Gray, Leonard C; Wootton, Richard

    2014-03-01

    Although the basic PubMed search is often helpful, the results may sometimes be non-specific. For more control over the search process you can use the Advanced Search Builder interface. This allows a targeted search in specific fields, with the convenience of being able to select the intended search field from a list. It also provides a history of your previous searches. The search history is useful to develop a complex search query by combining several previous searches using Boolean operators. For indexing the articles in MEDLINE, the NLM uses a controlled vocabulary system called MeSH. This standardised vocabulary solves the problem of authors, researchers and librarians who may use different terms for the same concept. To be efficient in a PubMed search, you should start by identifying the most appropriate MeSH terms and use them in your search where possible. My NCBI is a personal workspace facility available through PubMed and makes it possible to customise the PubMed interface. It provides various capabilities that can enhance your search performance.

  11. 77 FR 56237 - Notice of Permit Applications Received Under the Antarctic Conservation Act of 1978 (Pub. L. 95-541)

    Science.gov (United States)

    2012-09-12

    ... Conservation Act of 1978, Public Law 95-541. SUMMARY: The National Science Foundation (NSF) is required to... INFORMATION: The National Science Foundation, as directed by the Antarctic Conservation Act of 1978 (Pub. L. 95-541), as amended by the Antarctic Science, Tourism and Conservation Act of 1996, has...

  12. How to Write Easy-to-Read Health Materials: MedlinePlus

    Science.gov (United States)

    ... for some. Health Literacy Advisor by Health Literacy Innovations (Add-on to Microsoft Word) TextQuest by Social ... and information on creating actionable health materials National Library of Medicine: MEDLINE/PubMed Search and Health Literacy ...

  13. Mentoring programs for medical students - a review of the PubMed literature 2000 - 2008

    Science.gov (United States)

    2010-01-01

    Background Although mentoring is acknowledged as a key to successful and satisfying careers in medicine, formal mentoring programs for medical students are lacking in most countries. Within the framework of planning a mentoring program for medical students at Zurich University, an investigation was carried out into what types of programs exist, what the objectives pursued by such programs are, and what effects are reported. Methods A PubMed literature search was conducted for 2000 - 2008 using the following keywords or their combinations: mentoring, mentoring program, medical student, mentor, mentee, protégé, mentorship. Although a total of 438 publications were identified, only 25 papers met the selection criteria for structured programs and student mentoring surveys. Results The mentoring programs reported in 14 papers aim to provide career counseling, develop professionalism, increase students' interest in research, and support them in their personal growth. There are both one-to-one and group mentorships, established in the first two years of medical school and continuing through graduation. The personal student-faculty relationship is important in that it helps students to feel that they are benefiting from individual advice and encourages them to give more thought to their career choices. Other benefits are an increase in research productivity and improved medical school performance in general. Mentored students also rate their overall well-being as higher. - The 11 surveys address the requirements for being an effective mentor as well as a successful mentee. A mentor should empower and encourage the mentee, be a role model, build a professional network, and assist in the mentee's personal development. A mentee should set agendas, follow through, accept criticism, and be able to assess performance and the benefits derived from the mentoring relationship. Conclusion Mentoring is obviously an important career advancement tool for medical students. In Europe

  14. Mentoring programs for medical students - a review of the PubMed literature 2000 - 2008

    Directory of Open Access Journals (Sweden)

    Buddeberg-Fischer Barbara

    2010-04-01

    Full Text Available Abstract Background Although mentoring is acknowledged as a key to successful and satisfying careers in medicine, formal mentoring programs for medical students are lacking in most countries. Within the framework of planning a mentoring program for medical students at Zurich University, an investigation was carried out into what types of programs exist, what the objectives pursued by such programs are, and what effects are reported. Methods A PubMed literature search was conducted for 2000 - 2008 using the following keywords or their combinations: mentoring, mentoring program, medical student, mentor, mentee, protégé, mentorship. Although a total of 438 publications were identified, only 25 papers met the selection criteria for structured programs and student mentoring surveys. Results The mentoring programs reported in 14 papers aim to provide career counseling, develop professionalism, increase students' interest in research, and support them in their personal growth. There are both one-to-one and group mentorships, established in the first two years of medical school and continuing through graduation. The personal student-faculty relationship is important in that it helps students to feel that they are benefiting from individual advice and encourages them to give more thought to their career choices. Other benefits are an increase in research productivity and improved medical school performance in general. Mentored students also rate their overall well-being as higher. - The 11 surveys address the requirements for being an effective mentor as well as a successful mentee. A mentor should empower and encourage the mentee, be a role model, build a professional network, and assist in the mentee's personal development. A mentee should set agendas, follow through, accept criticism, and be able to assess performance and the benefits derived from the mentoring relationship. Conclusion Mentoring is obviously an important career advancement tool for

  15. Primary health care and disasters-the current state of the literature: what we know, gaps and next steps.

    Science.gov (United States)

    Redwood-Campbell, Lynda; Abrahams, Jonathan

    2011-06-01

    The 2009 Global Platform for Disaster Risk Reduction/Emergency Preparedness (DRR/EP) and the Hyogo Framework for Action 2005-2015 demonstrate increased international commitment to DRR/EP in addition to response and recovery. In addition, the World Health Report 2008 has re-focused the world's attention on the renewal of Primary Health Care (PHC) as a set of values/principles for all sectors. Evidence suggests that access to comprehensive PHC improves health outcomes and an integrated PHC approach may improve health in low income countries (LICs). Strong PHC health systems can provide stronger health emergency management, which reinforce each other for healthier communities. The global re-emphasis of PHC recently necessitates the health sector and the broader disaster community to consider health emergency management from the perspective of PHC. How PHC is being described in the literature related to disasters and the quality of this literature is reviewed. Identifying which topics/lessons learned are being published helps to identify key lessons learned, gaps and future directions. Fourteen major scientific and grey literature databases searched. Primary Health Care or Primary Care coupled with the term disaster was searched (title or abstract). The 2009 ISDR definition of disaster and the 1978 World Health Organization definition of Primary Health Care were used. 119 articles resulted. Literature characteristics; 16% research papers, only 29% target LICs, 8% of authors were from LICs, 7% clearly defined PHC, 50% used PHC to denote care provided by clinicians and 4% cited PHC values and principles. Most topics related to disaster response. Key topics; true need for PHC, mental health, chronic disease, models of PHC, importance of PHC soon after a natural disaster relative to acute care, methods of surge capacity, utilization patterns in recovery, access to vulnerable populations, rebuilding with the PHC approach and using current PHC infrastructure to build

  16. PubMed和CNKI收录炎症性肠病文献计量学分析%Metrological Analysis on Inflammatory Bowel Disease from PubMed and CNKI

    Institute of Scientific and Technical Information of China (English)

    崔悦; 许昌泰

    2013-01-01

    Objective To analyze domestic and foreign literature growth regularity and main factors that affect future development of inflammatory bowel disease ( IBD )from PubMed and CNKI. Methods It respectively searched the literature quantity year by year in PubMed from 1945 to 2010 and CNKI from 1978 to 2010 by IBD and its hyponym;ulcerative colitis( UC )and Crohn's disease( CD ). Then it carried out linear regression analysis with the searching results in PubMed and CNKI. Meanwhile, it analyzed IBD papers published in domestic and foreign journals. Results The literature accumulation year by year of IBD, UC and CD increased in PubMed and CNKI. The scattered point diagram was in exponential growing trend( Y = aex ),which was slower in the early time but rapidly in the last few years. There were 63 824 IBD literatures in abroad,80. 54%( 49 284 of 61 195 )of which were in English version. The literatures in CNKI were 15 780,40.14% ( 6334 of 15 780 )of which were published in core journals. Conclusion The literature accumulation of IBD is increasing in PubMed and CNKI, indicating that IBD still remains a hotspot. The main factor affecting the growth of literature in IBD is discipline inherent regularity abroad,but discipline environment in China.%目的 分析PubMed和CNKI炎症性肠病(IBD)文献增长规律及影响其发展的主要因素.方法 用IBD及其下位词溃疡性结肠炎(UC)和克罗恩病(CD)分别逐年检索1945 ~2010年PubMed中收录的文献量和1978 ~2010年CNKI中收录的文献量,之后分别对PubMed和CNKI中收录的文献进行线性回归分析,同时分析国内外相关期刊刊载IBD的论文.结果 国内外IBD、UC和CD逐年累积文献量呈上升趋势,IBD、UC和CD散点图均呈指数增长趋势(Y=aeX),前期增长速度较为缓慢,近年来增长速度逐步加快.国外63 824篇IBD文献中,英文49 284篇,为80.54%(49 284/61 195).国内相关文献15 780篇,其中IBD文献主要刊载于核心期刊6334篇,达40.14%.

  17. 利用PubMed构建医药企业文献支持平台%The Construction of Literature Supporting Platform for Drug Enterprises Utilizing PubMed

    Institute of Scientific and Technical Information of China (English)

    胡书明

    2012-01-01

    基于PubMed程序接口进行二次程序开发,从需求分析、基础架构、实现流程等方面介绍医药企业文献支持平台的构建,实现企业特色文献资源的积累、及时更新以及集约化使用。%The paper carries out secondary program development based on PubMed interfaces,introduces the construction of literature supporting platform for drug enterprises from the aspects of requirements analysis,basic framework,realization process and so on,so as to realize accumulation,timely update and intensive utilization of characteristic literature resources in enterprises.

  18. Publicaciones médicas procesadas en las bases de datos PubMed y CUMED: Cienfuegos 1998-2007Medical publications processed in CUMED and PubMed data bases: Cienfuegos, Cuba, 1998-2007

    Directory of Open Access Journals (Sweden)

    Lourdes Luques Hernández

    2009-01-01

    Full Text Available Objetivo: caracterizar la producción científica de las ciencias médicas de Cienfuegos.Material y Método: estudio descriptivo bibliométrico. Se realizó una búsqueda en las bases dedatos PubMed y CUMED durante el periodo 1998 – 2007. En la estrategia de búsqueda se utilizóla palabra “Cienfuegos” en PubMed y CUMED Habana, mientras en CUMED Cienfuegos “$”.Se analizaron el número de publicaciones, tipo e idioma, nombre de la revista, país editor,institución de procedencia entre otras variables. Fueron excluidos los registros fuera del periodo,repetidos, incongruentes, capturas erróneas, solapamiento, cd-rom, resúmenes, libros.Resultados: se estudiaron un total de 288 publicaciones. En general, el número de publicacionespor años se incrementó progresivamente con una tendencia al incremento, excepto en los dosúltimos años, 2006 y 2007. En PubMed el 51.3% de las publicaciones aparecieron en RevistaNeurología y British Medical Journal, en CUMED Habana el 48.6% aparecieron en Medisur,Revista Cubana de Medicina y Revista Cubana de Pediatría y en CUMED Cienfuegos el 92.2%en Medisur y Finlay. El Hospital Provincial Dr. Gustavo Aldereguía Lima tuvo el mayor númerode publicaciones en PubMed (83.8% y CUMED Cienfuegos (47.9%. El original fue el tipo depublicación más frecuente con 56.6%. En general predominaron los temas de Medicina Interna(18.1% y Pediatría (16.3%.Conclusiones: se observó por primera vez, con algunos detalles, cuál ha sido la actividadinvestigadora de los profesionales de la salud en Cienfuegos.Objective: to characterize the scientific production of the medical science school in Cienfuegos,Cuba.Material and methods: a bibliometric descriptive study in the CUMED and PubMed data basesfrom 1998 to 2007. In the searching strategy the word “Cienfuegos” was used in PubMed andalso in Havana CUMED, meanwhile in Cienfuegos CUMED “$” was used. The number ofpublications, languages and types, name of the

  19. Achieving a "Grand Convergence" in Global Health: Modeling the Technical Inputs, Costs, and Impacts from 2016 to 2030.

    Science.gov (United States)

    Boyle, Colin F; Levin, Carol; Hatefi, Arian; Madriz, Solange; Santos, Nicole

    2015-01-01

    The Commission on Investing in Health published its report, GlobalHealth2035, in 2013, estimating an investment case for a grand convergence in health outcomes globally. In support of the drafting of the Sustainable Development Goals (SDGs), we estimate what the grand convergence investment case might achieve-and what investment would be required-by 2030. Our projection focuses on a sub-set of low-income (LIC) or lower-middle-income countries (LMIC). We start with a country-based (bottom-up) analysis of the costs and impact of scaling up reproductive, maternal, and child health tools, and select HIV and malaria interventions. We then incorporate global (top-down) analyses of the costs and impacts of scaling up existing tools for tuberculosis, additional HIV interventions, the costs to strengthen health systems, and the costs and benefits from scaling up new health interventions over the time horizon of this forecast. These data are then allocated to individual countries to provide an aggregate projection of potential cost and impact at the country level. Finally, incremental costs of R&D for low-income economies and the costs of addressing NTDs are added to provide a global total cost estimate of the investment scenario. Compared with a constant coverage scenario, there would be more than 60 million deaths averted in LIC and 70 million deaths averted in LMIC between 2016 and 2030. For the years 2015, 2020, 2025, and 2030, the incremental costs of convergence in LIC would be (US billion) $24.3, $21.8, $24.7, and $27, respectively; in LMIC, the incremental costs would be (US billion) $34.75, $38.9, $48.7, and $56.3, respectively. Key health outcomes in low- and low-middle income countries can significantly converge with those of wealthier countries by 2030, and the notion of a "grand convergence" may serve as a unifying theme for health indicators in the SDGs.

  20. Demystifying the Search Button: A Comprehensive PubMed Search Strategy for Performing an Exhaustive Literature Review.

    Science.gov (United States)

    McKeever, Liam; Nguyen, Van; Peterson, Sarah J; Gomez-Perez, Sandra; Braunschweig, Carol

    2015-08-01

    A thorough review of the literature is the basis of all research and evidence-based practice. A gold-standard efficient and exhaustive search strategy is needed to ensure all relevant citations have been captured and that the search performed is reproducible. The PubMed database comprises both the MEDLINE and non-MEDLINE databases. MEDLINE-based search strategies are robust but capture only 89% of the total available citations in PubMed. The remaining 11% include the most recent and possibly relevant citations but are only searchable through less efficient techniques. An effective search strategy must employ both the MEDLINE and the non-MEDLINE portion of PubMed to ensure all studies have been identified. The robust MEDLINE search strategies are used for the MEDLINE portion of the search. Usage of the less robust strategies is then efficiently confined to search only the remaining 11% of PubMed citations that have not been indexed for MEDLINE. The current article offers step-by-step instructions for building such a search exploring methods for the discovery of medical subject heading (MeSH) terms to search MEDLINE, text-based methods for exploring the non-MEDLINE database, information on the limitations of convenience algorithms such as the "related citations feature," the strengths and pitfalls associated with commonly used filters, the proper usage of Boolean operators to organize a master search strategy, and instructions for automating that search through "MyNCBI" to receive search query updates by email as new citations become available.

  1. PubMed收录产后出血相关文献的计量学分析

    Institute of Scientific and Technical Information of China (English)

    郝金凤

    2015-01-01

    PubMed收最的产后出血相关文献的年份、国别、期刊来源、多产作者、主要主题词进行统计,并对有关数据进行分析,以明确产后出血相关文献分布特点和研究现状.

  2. PubMed收录葡萄胎相关文献的计量学分析

    Institute of Scientific and Technical Information of China (English)

    郝金凤

    2015-01-01

    PubMed收录的葡萄胎相关文献的年份、国别、期刊来源、多产作者、主要主题词进行统计,并对有关数据进行分析,以明确葡萄胎相关文献分布特点和研究现状.

  3. PubMed收录羊水栓塞相关文献的计量学分析

    Institute of Scientific and Technical Information of China (English)

    张丽娟

    2015-01-01

    PubMed收录的羊水栓塞相关文献的年份、国别、期刊来源、多产作者、主要主题词进行统计,并对有关数据进行分析,以明确羊水栓塞相关文献分布特点和研究现状.

  4. PubMed收录胃溃疡手术相关文献的计量学分析

    Institute of Scientific and Technical Information of China (English)

    麻立民; 王文亮

    2015-01-01

    PubMed收录的胃溃疡手术相关文献的年份、国别、期刊来源、多产作者、主要主题词进行统计,并对有关数据进行分析,以明确胃溃疡手术相关文献分布特点和研究现状。

  5. PubMed收录脑室造瘘术相关文献的计量学分析

    Institute of Scientific and Technical Information of China (English)

    刘建锋

    2014-01-01

    PubMed收录的脑室造瘘术相关文献的年份、国别、期刊来源、多产作者、主要主题词进行统计,并对有关数据进行分析,以明确脑室造瘘术相关文献分布特点和研究现状。

  6. PubMed收录护患关系相关文献的计量学分析

    Institute of Scientific and Technical Information of China (English)

    汤晓双

    2015-01-01

    PubMed收录的近5年护患关系相关文献的年份、国别、期刊来源、多产作者、主要主题词进行统计,并对有关数据进行分析,以明确护患关系相关文献分布特点和研究现状.

  7. PubMed收录循证护理相关文献的计量学分析

    Institute of Scientific and Technical Information of China (English)

    汤晓双

    2015-01-01

    PubMed收录的循证护理相关文献的年份、国别、期刊来源、多产作者、主要主题词进行统计,并对有关数据进行分析,以明确循证护理相关文献分布特点和研究现状.

  8. PubMed收录前置胎盘相关文献的计量学分析

    Institute of Scientific and Technical Information of China (English)

    郝金凤

    2015-01-01

    PubMed收录的前置胎盘相关文献的年份、国别、期刊来源、多产作者、主要主题词进行统计,并对有关数据进行分析,以明确前置胎盘相关文献分布特点和研究现状.

  9. PubMed收录胎盘早剥相关文献的计量学分析

    Institute of Scientific and Technical Information of China (English)

    张丽娟

    2015-01-01

    PubMed收录的胎盘早剥相关文献的年份、国别、期刊来源、多产作者、主要主题词进行统计,并对有关数据进行分析,以明确胎盘早剥相关文献分布特点和研究现状.

  10. PubMed收录烧伤护理相关文献的计量学分析

    Institute of Scientific and Technical Information of China (English)

    汤晓双

    2015-01-01

    PubMed收录的烧伤护理相关文献的年份、国别、期刊来源、多产作者、主要主题词进行统计,并对有关数据进行分析,以明确烧伤护理相关文献分布特点和研究现状.

  11. PubMed收录围手术期护理相关文献的计量学分析

    Institute of Scientific and Technical Information of China (English)

    汤晓双

    2015-01-01

    PubMed收录的围手术期护理相关文献的年份、国别、期刊来源、多产作者、主要主题词进行统计,并对有关数据进行分析,以明确围手术期护理相关文献分布特点和研究现状。

  12. PubMed收录肿瘤护理相关文献的计量学分析

    Institute of Scientific and Technical Information of China (English)

    曹玲玲

    2014-01-01

    PubMed收录的肿瘤护理相关文献的年份、国别、期刊来源、多产作者、主要主题词进行统计,并对有关数据进行分析,以明确肿瘤护理相关文献分布特点和研究现状。

  13. PubMed收录蛋白尿相关文献的计量学分析

    Institute of Scientific and Technical Information of China (English)

    徐雪阳

    2015-01-01

    PubMed收录的近10年蛋白尿相关文献的年份。国别,期刊来源.多产作者。主要主题词进行统计,并对有关数据进行分析,以明确蛋白尿相关文献分布特点和研究现状。

  14. PubMed收录整体护理相关文献的计量学分析

    Institute of Scientific and Technical Information of China (English)

    汤晓双

    2015-01-01

    PubMed收录的整体护理相关文献的年份、国别、期刊来源、多产作者、主要主题词进行统计,并对有关数据进行分析,以明确整体护理相关文献分布特点和研究现状。

  15. PubMed收录胆石症相关文献的计量学分析

    Institute of Scientific and Technical Information of China (English)

    杜常志

    2015-01-01

    PubMed收录的胆石症近10年相关文献的年份、国别、期刊来源、多产作者、主要主题词进行统计,并对有关数据进行分析,以明确胆石症相关文献分布特点和研究现状.

  16. PubMed收录血管紧张素Ⅱ相关文献的计量学分析

    Institute of Scientific and Technical Information of China (English)

    徐雪阳

    2015-01-01

    PubMed收录的血管紧张素Ⅱ近10年相关文献的年份、国别、期刊来源、多产作者、主要主题词进行统计,并对有关数据进行分析,以明确血管紧张素Ⅱ相关文献分布特点和研究现状。

  17. PubMed收录疝修补术相关文献的计量学分析

    Institute of Scientific and Technical Information of China (English)

    杜常志

    2015-01-01

    PubMed收录的疝修补术相关文献的年份、国别、期刊来源、多产作者、主要主题词进行统计,并对有关数据进行分析,以明确疝修补术相关文献分布特点和研究现状.

  18. PubMed收录肝硬化病理学相关文献的计量学分析

    Institute of Scientific and Technical Information of China (English)

    李娜

    2016-01-01

    PubMed收录的近10年肝硬化病理学相关文献的年份、国别、期刊来源、多产作者、主要主题词进行统计,并对有关数据进行分析,以明确肝硬化病理学相关文献分布特点和研究现状。

  19. PubChemQC Project: A Large-Scale First-Principles Electronic Structure Database for Data-Driven Chemistry.

    Science.gov (United States)

    Nakata, Maho; Shimazaki, Tomomi

    2017-06-26

    Large-scale molecular databases play an essential role in the investigation of various subjects such as the development of organic materials, in silico drug design, and data-driven studies with machine learning. We have developed a large-scale quantum chemistry database based on first-principles methods. Our database currently contains the ground-state electronic structures of 3 million molecules based on density functional theory (DFT) at the B3LYP/6-31G* level, and we successively calculated 10 low-lying excited states of over 2 million molecules via time-dependent DFT with the B3LYP functional and the 6-31+G* basis set. To select the molecules calculated in our project, we referred to the PubChem Project, which was used as the source of the molecular structures in short strings using the InChI and SMILES representations. Accordingly, we have named our quantum chemistry database project "PubChemQC" ( http://pubchemqc.riken.jp/ ) and placed it in the public domain. In this paper, we show the fundamental features of the PubChemQC database and discuss the techniques used to construct the data set for large-scale quantum chemistry calculations. We also present a machine learning approach to predict the electronic structure of molecules as an example to demonstrate the suitability of the large-scale quantum chemistry database.

  20. PubMed is Slightly More Sensitive but More Time Intensive to Search than Ovid MEDLINE. A Review of: Katchamart, W., Faulkner, A., Feldman, B., Tomlinson, G., & Bombardier, C. (2011. PubMed had a higher sensitivity than Ovid-MEDLINE in the search for systematic reviews. Journal of Clinical Epidemiology, 64(7, 805-807. doi:10.1016/j.jclinepi.2010.06.004

    Directory of Open Access Journals (Sweden)

    Cari Merkley

    2011-06-01

    Full Text Available Objective — To compare the results of searching the MEDLINE database through Ovid and the free online version of PubMed administered by the National Library of Medicine for randomized controlled trials on the subject of the drug methotrexate (MTX for patients suffering from rheumatoid arthritis.Design — Comparative analysis of search results.Setting — Searches conducted by researchers affiliated with Mahidol University in Bangkok, Thailand, and the University of Toronto and the University Health Network in Toronto, Ontario.Subjects — A total of 3966 search results obtained from Ovid MEDLINE and PubMed.Methods — This study employs an Ovid MEDLINE search strategy originally created for a published systematic review that identified randomized controlled trials on MTX and rheumatoid arthritis (Katchamart, Trudeau, Phumethum, & Bombardier, 2009. Two of the authors of the original systematic review (Katchamart and Bombardier are among the authors of this current study.Appropriate medical subject heading (MeSH terms and their synonyms were identified for the three main concepts (rheumatoid arthritis, MTX, and randomized controlled trials. The search was performed in Ovid MEDLINE, seeking articles in any language that met the terms using the Boolean operator OR. The searches for the three concepts were finally combined using AND. The Ovid MEDLINE search was then translated for use in PubMed by an information professional. The formatting and terminology used in some of the original Ovid MEDLINE search statements had to be changed so they would work in the new database environment, but the researchers tried to ensure that the two searches were as similar as possible. The translated search was then executed in PubMed.The final results, as well as the number of articles retrieved for each key search concept (rheumatoid arthritis, MTX, and randomized controlled trials, were then compared. The final results were further analyzed for measures of

  1. Di-methyl-ammonium 2,4,5-tri-carb-oxy-benzoate: an example of the deca-rbonylation of N,N-di-methyl-formamide in the presence of a metal and a benzene-polycarb-oxy-lic acid. Is zirconium(IV) the Tsotsi?

    Science.gov (United States)

    Hulushe, S T; Hosten, E C; Watkins, G M

    2016-11-01

    The title salt, C2H8N(+)·C10H5O8(-), was the unexpected product of an attempt to prepare a Zr(IV) metal-organic framework with benzene-1,2,4,5-tetra-carb-oxy-lic acid (1,2,4,5-H3B4C). In the reaction, the DMF solvent has been decarb-on-yl-ated, forming the di-methyl-ammonium cation, with one proton lost from the tetra-carb-oxy-lic acid. It is proposed that the Zr(IV) salt acts as a Tsotsi or robber, plundering CO from the DMF mol-ecule. The resulting salt crystallizes with two cations and two anions in the asymmetric unit. An intra-molecular hydrogen bond forms between a carb-oxy-lic acid substituent and the carboxyl-ate group of each of the monodeprotonated (1,2,4,5-H3B4C(-)) anions. In the crystal, an extensive array of O-H⋯O, N-H⋯O and C-H⋯O hydrogen bonds generates a three-dimensional network, with columns of cations and anions forming along the b axis.

  2. Crystal structure of 8-[7,8-bis-(4-chloro-benzo-yl)-7H-cyclo-penta-[a]ace-naphthylen-9-yl]naphthalene-1-carb-oxy-lic acid.

    Science.gov (United States)

    Jacob, Jomon P; Sithambaresan, M; Kunjachan, Christy; Kurup, M R Prathapachandra

    2015-01-01

    The title compound, C40H22Cl2O4, was formed by a Michael-Aldol domino reaction sequence, which coupled acenaphthene-quinone with 4-chloro-aceto-phenone in the presence of KOH in methanol. The dihedral angles between the central cyclo-penta-[a]ace-naphthyl-ene fused-ring system (r.m.s. deviation = 0.066 Å) and the 4-chloro-benzoyl rings are 62.25 (10) and 70.19 (10)°. The dihedral angle between the central ring system and the naphthoic acid grouping is 62.46 (7)°. This twisting of the pendant rings facilitates the formation of an intra-molecular aromatic π-π stacking inter-action between the 4-chloro-benzoyl and naphthoic acid rings, with centroid-centroid distances of 3.4533 (16) and 3.5311 (16) Å, and a C-H⋯π inter-action between one of the H atoms of the central moiety and the 4-chloro-benzoyl ring with an H⋯π distance of 2.57 Å. In the crystal, carb-oxy-lic acid inversion dimers generate R 2 (2)(8) loops. The dimers are linked by weak C-H⋯O and C-H⋯Cl hydrogen bonds and C-H⋯π inter-actions, generating a three-dimensional architecture.

  3. Answers to questions posed during daily patient care are more likely to be answered by UpToDate than PubMed.

    NARCIS (Netherlands)

    Hoogendam, A.; Stalenhoef, A.F.H.; Robbe, P.F.; Overbeke, A.J.P.M.

    2008-01-01

    BACKGROUND: UpToDate and PubMed are popular sources for medical information. Data regarding the efficiency of PubMed and UpToDate in daily medical care are lacking. OBJECTIVE: The purpose of this observational study was to describe the percentage of answers retrieved by these information sources, co

  4. 专业的语义智能搜索引擎Quertle——与GoPubMed的比较研究

    Institute of Scientific and Technical Information of China (English)

    施李丽

    2012-01-01

    GoPubMed是基于PubMed的语义智能搜索引擎,Quertle是以PubMed为主要数据源的语义智能搜索引擎,两者都是基于本体向未来语义检索发展的尝试。GoPubMed最大的检索特色是对检索结果的分类统计和可视化。Quertle在本体技术和自然语言处理技术的支撑下,形成了Power TermTM检索,能识别单词大写时的特定含义,将检索提问与关系网进行匹配查找获得高度相关的检索结果。%GoPubMed is an intelligent semantic search engine based on PubMed, and Quertle is an intelligent semantic search engine taking PubMed as the main data source. Both of them are the attempts for the future development of semantic search based on ontology. The search feature Of GoPubMed is the classification, statistics and visualization of retrieval results. The search features of Quertle include Power Terms, understanding capitalization, finding highly relevant results by comparing search queries with the database of relationships.

  5. Analysis of queries sent to PubMed at the point of care : observation of search behaviour in a medical teaching hospital

    NARCIS (Netherlands)

    Hoogendam, A.; Stalenhoef, A.F.H.; Robbe, P.F.; Overbeke, A.J.P.M.

    2008-01-01

    BACKGROUND: The use of PubMed to answer daily medical care questions is limited because it is challenging to retrieve a small set of relevant articles and time is restricted. Knowing what aspects of queries are likely to retrieve relevant articles can increase the effectiveness of PubMed searches.

  6. Analysis of queries sent to PubMed at the point of care : observation of search behaviour in a medical teaching hospital

    NARCIS (Netherlands)

    Hoogendam, A.; Stalenhoef, A.F.H.; Robbe, P.F.; Overbeke, A.J.P.M.

    2008-01-01

    BACKGROUND: The use of PubMed to answer daily medical care questions is limited because it is challenging to retrieve a small set of relevant articles and time is restricted. Knowing what aspects of queries are likely to retrieve relevant articles can increase the effectiveness of PubMed searches. T

  7. Dry Mouth: MedlinePlus Health Topic

    Science.gov (United States)

    ... I Do about Dry Mouth? (National Institute of Dental and Craniofacial Research) Clinical Trials ClinicalTrials.gov: Xerostomia (National Institutes of Health) Journal Articles References and abstracts from MEDLINE/PubMed (National ...

  8. Rickets: MedlinePlus Health Topic

    Science.gov (United States)

    ... ClinicalTrials.gov: Rickets, Hypophosphatemic (National Institutes of Health) Journal Articles References and abstracts from MEDLINE/PubMed (National Library of Medicine) Article: QUALITY OF LIFE OF CHILDREN WITH RICKETS IN YOUNG AGE... Article: ...

  9. Publications in PubMed on Ebola and the 2014 outbreak [version 2; referees: 2 approved

    Directory of Open Access Journals (Sweden)

    Andrea Ballabeni

    2015-10-01

    Full Text Available In this research note we examine the biomedical publication output about Ebola in 2014. We show that the volume of publications has dramatically increased in the past year. In 2014 there have been over 888 publications with ‘ebola’ or ‘ebolavirus’ in the title, approximately 13 times the volume of publication of 2013. The rise reflects an impressive growth starting in the month of August, concomitant with or following the surge in infections, deaths and coverage in news and social media. Though non-research articles have been the major contributors to this growth, there has been a substantial increase in original research articles too, including many papers of basic science. The United States has been the country with the highest number of research articles, followed by Canada and the United Kingdom. We present a comprehensive set of charts and facts that, by describing the volumes and nature of publications in 2014, show how the scientific community has responded to the Ebola outbreak and how it might respond to future similar global threats and media events. This information will assist scholars and policymakers in their efforts to improve scientific research policies with the goal of maximizing both public health and knowledge advancement.

  10. The quality of the reported sample size calculations in randomized controlled trials indexed in PubMed.

    Science.gov (United States)

    Lee, Paul H; Tse, Andy C Y

    2017-05-01

    There are limited data on the quality of reporting of information essential for replication of the calculation as well as the accuracy of the sample size calculation. We examine the current quality of reporting of the sample size calculation in randomized controlled trials (RCTs) published in PubMed and to examine the variation in reporting across study design, study characteristics, and journal impact factor. We also reviewed the targeted sample size reported in trial registries. We reviewed and analyzed all RCTs published in December 2014 with journals indexed in PubMed. The 2014 Impact Factors for the journals were used as proxies for their quality. Of the 451 analyzed papers, 58.1% reported an a priori sample size calculation. Nearly all papers provided the level of significance (97.7%) and desired power (96.6%), and most of the papers reported the minimum clinically important effect size (73.3%). The median (inter-quartile range) of the percentage difference of the reported and calculated sample size calculation was 0.0% (IQR -4.6%;3.0%). The accuracy of the reported sample size was better for studies published in journals that endorsed the CONSORT statement and journals with an impact factor. A total of 98 papers had provided targeted sample size on trial registries and about two-third of these papers (n=62) reported sample size calculation, but only 25 (40.3%) had no discrepancy with the reported number in the trial registries. The reporting of the sample size calculation in RCTs published in PubMed-indexed journals and trial registries were poor. The CONSORT statement should be more widely endorsed. Copyright © 2016 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.

  11. High-performance information search filters for acute kidney injury content in PubMed, Ovid Medline and Embase.

    Science.gov (United States)

    Hildebrand, Ainslie M; Iansavichus, Arthur V; Haynes, R Brian; Wilczynski, Nancy L; Mehta, Ravindra L; Parikh, Chirag R; Garg, Amit X

    2014-04-01

    We frequently fail to identify articles relevant to the subject of acute kidney injury (AKI) when searching the large bibliographic databases such as PubMed, Ovid Medline or Embase. To address this issue, we used computer automation to create information search filters to better identify articles relevant to AKI in these databases. We first manually reviewed a sample of 22 992 full-text articles and used prespecified criteria to determine whether each article contained AKI content or not. In the development phase (two-thirds of the sample), we developed and tested the performance of >1.3-million unique filters. Filters with high sensitivity and high specificity for the identification of AKI articles were then retested in the validation phase (remaining third of the sample). We succeeded in developing and validating high-performance AKI search filters for each bibliographic database with sensitivities and specificities in excess of 90%. Filters optimized for sensitivity reached at least 97.2% sensitivity, and filters optimized for specificity reached at least 99.5% specificity. The filters were complex; for example one PubMed filter included >140 terms used in combination, including 'acute kidney injury', 'tubular necrosis', 'azotemia' and 'ischemic injury'. In proof-of-concept searches, physicians found more articles relevant to topics in AKI with the use of the filters. PubMed, Ovid Medline and Embase can be filtered for articles relevant to AKI in a reliable manner. These high-performance information filters are now available online and can be used to better identify AKI content in large bibliographic databases.

  12. Speed, accuracy, and confidence in Google, Ovid, PubMed, and UpToDate: results of a randomised trial.

    Science.gov (United States)

    Thiele, Robert H; Poiro, Nathan C; Scalzo, David C; Nemergut, Edward C

    2010-08-01

    The explosion of biomedical information has led to an 'information paradox'-the volume of biomedical information available has made it increasingly difficult to find relevant information when needed. It is thus increasingly critical for physicians to acquire a working knowledge of biomedical informatics. To evaluate four search tools commonly used to answer clinical questions, in terms of accuracy, speed, and user confidence. From December 2008 to June 2009, medical students, resident physicians, and attending physicians at the authors' institution were asked to answer a set of four anaesthesia and/or critical care based clinical questions, within 5 min, using Google, Ovid, PubMed, or UpToDate (only one search tool per question). At the end of each search, participants rated their results on a four point confidence scale. One to 3 weeks after answering the initial four questions, users were randomised to one of the four search tools, and asked to answer eight questions, four of which were repeated. The primary outcome was defined as a correct answer with the highest level of confidence. Google was the most popular search tool. Users of Google and UpToDate were more likely than users of PubMed to answer questions correctly. Subjects had the most confidence in UpToDate. Searches with Google and UpToDate were faster than searches with PubMed or Ovid. Non-Medline based search tools are not inferior to Medline based search tools for purposes of answering evidence based anaesthesia and critical care questions.

  13. Automated Patent Categorization and Guided Patent Search using IPC as Inspired by MeSH and PubMed.

    Science.gov (United States)

    Eisinger, Daniel; Tsatsaronis, George; Bundschus, Markus; Wieneke, Ulrich; Schroeder, Michael

    2013-04-15

    Document search on PubMed, the pre-eminent database for biomedical literature, relies on the annotation of its documents with relevant terms from the Medical Subject Headings ontology (MeSH) for improving recall through query expansion. Patent documents are another important information source, though they are considerably less accessible. One option to expand patent search beyond pure keywords is the inclusion of classification information: Since every patent is assigned at least one class code, it should be possible for these assignments to be automatically used in a similar way as the MeSH annotations in PubMed. In order to develop a system for this task, it is necessary to have a good understanding of the properties of both classification systems. This report describes our comparative analysis of MeSH and the main patent classification system, the International Patent Classification (IPC). We investigate the hierarchical structures as well as the properties of the terms/classes respectively, and we compare the assignment of IPC codes to patents with the annotation of PubMed documents with MeSH terms.Our analysis shows a strong structural similarity of the hierarchies, but significant differences of terms and annotations. The low number of IPC class assignments and the lack of occurrences of class labels in patent texts imply that current patent search is severely limited. To overcome these limits, we evaluate a method for the automated assignment of additional classes to patent documents, and we propose a system for guided patent search based on the use of class co-occurrence information and external resources.

  14. Automated Patent Categorization and Guided Patent Search using IPC as Inspired by MeSH and PubMed

    Science.gov (United States)

    2013-01-01

    Document search on PubMed, the pre-eminent database for biomedical literature, relies on the annotation of its documents with relevant terms from the Medical Subject Headings ontology (MeSH) for improving recall through query expansion. Patent documents are another important information source, though they are considerably less accessible. One option to expand patent search beyond pure keywords is the inclusion of classification information: Since every patent is assigned at least one class code, it should be possible for these assignments to be automatically used in a similar way as the MeSH annotations in PubMed. In order to develop a system for this task, it is necessary to have a good understanding of the properties of both classification systems. This report describes our comparative analysis of MeSH and the main patent classification system, the International Patent Classification (IPC). We investigate the hierarchical structures as well as the properties of the terms/classes respectively, and we compare the assignment of IPC codes to patents with the annotation of PubMed documents with MeSH terms. Our analysis shows a strong structural similarity of the hierarchies, but significant differences of terms and annotations. The low number of IPC class assignments and the lack of occurrences of class labels in patent texts imply that current patent search is severely limited. To overcome these limits, we evaluate a method for the automated assignment of additional classes to patent documents, and we propose a system for guided patent search based on the use of class co-occurrence information and external resources. PMID:23734562

  15. The effects of smoking status and ventilation on environmental tobacco smoke concentrations in public areas of UK pubs and bars

    Science.gov (United States)

    Carrington, Joanna; Watson, Adrian F. R.; Gee, Ivan L.

    UK public houses generally allow smoking to occur and consequently customer ETS exposure can take place. To address this, in 1999 the UK Government and the hospitality industry initiated the Public Places Charter (PPC) to increase non-smoking facilities and provide better ventilation in public houses. A study involving 60 UK pubs, located in Greater Manchester, was conducted to investigate the effects of smoking area status and ventilation on ETS concentrations. ETS markers RSP, UVPM, FPM, SolPM and nicotine were sampled and analysed using established methodologies. ETS marker concentrations were significantly higher ( P avoid pubs with non-smoking areas thus reducing source strengths in the smoking areas of these pubs. Nicotine concentrations were not found to be significantly different in smoking areas of the two types of establishment indicating that nicotine is not as mobile in these environments and tends to remain in the smoking areas. This result, together with the much higher reductions in nicotine concentrations between smoking and non-smoking areas compared to other markers, suggests that nicotine is not the most suitable marker to use in these environments as an indicator of the effectiveness of tobacco control policies. The use of ventilation systems (sophisticated HVAC systems and extractor fans in either the on or off mode) did not have a significant effect ( P > 0.05) on ETS marker concentrations in either the smoking or non-smoking areas. The PPC aims to reduce non-smoking customers' exposure through segregation and ventilation and provide customer choice though appropriate signs. This study indicates that although ETS levels are lower in non-smoking sections and signs will assist customers in reducing their exposure, some exposure will still occur because ETS was detected in non-smoking areas. Existing ventilation provision was not effective in reducing exposure and signs advertising ventilated premises may be misleading to customers. Improvements

  16. Pharmacy journal abstracts published in PubMed that abide by the CONsolidated Standards Of Reporting Trials (CONSORT) guidelines.

    Science.gov (United States)

    Blair, Daniel A; Hughes, Peter J; Woolley, Thomas W

    2014-04-01

    The purpose of this research was to determine the proportion of abstracts in pharmacy journals that are prepared according to the CONsolidated Standards Of Reporting Trials (CONSORT) criteria for abstracts. Certain abstracts for randomized controlled clinical trials (RCTs) indexed in PubMed were eligible for inclusion, with the primary endpoint being median overall compliance to CONSORT recommendations for abstracts. A total of 63 RCT abstracts were included in the analysis, with only 56% of the recommended CONSORT items represented in the sample. It is recommended that pharmacy journals encourage authors to follow CONSORT recommendations for abstracts when submitting RCTs for publication.

  17. Application of GoPubMed in bibliometric analysis of literature on CRISPR%利用GoPubMed对CRISPR相关文献的计量学分析

    Institute of Scientific and Technical Information of China (English)

    边富宁; 李文革; 李先平; 卢金星

    2014-01-01

    为了解CRISPR(clustered regularly interspaced short palindromic repeats)相关研究现状,笔者采用GoPubMed数据库的在线分析软件,对CRISPR相关文献进行计量分析.共检索到文献758篇.CRISPR相关研究文献呈逐年上升趋势,其中美国在CRISPR的文献数量和影响力均居首位,中国以北京地区发表文献最多(30篇).PLoS One刊登相关文献47篇,占发表总量的6.20%,居首位.CRISPR研究主题词涉及基因、基因组学、免疫等.高产作者为Horvath,共发表CRISPR相关文章11篇.利用GoPubMed可较好反映CRISPR研究的现状和发展趋势.中国CRISPR研究文献在整体质量和数量上均有待进一步提高.

  18. 基于PubMed数据库国外慢性病管理研究的现状分析%Analysis of the status quo of foreign chronic disease management research based on PubMed database

    Institute of Scientific and Technical Information of China (English)

    赵娜; 崔文香

    2014-01-01

    This article selects chronic disease management research of academic literatures published in the national library in PubMed database from January 2000 to December 2013.Literature Bicomb co-occurrence analysis system was used for data extraction,analysis on the current international research achievements of chronic disease management,development situation and existing problems,reveal the research trend of chronic disease management and the status quo,which provided reference for the similar domestic research.%本文选取美国国立图书馆PubMed数据库中2000年1月至2013年12月公开发表的慢性病管理研究的学术文献,运用文献共现分析系统Bicomb进行数据提取,分析目前国际上慢性病管理的研究成果、发展状况及现存问题,揭示慢性病管理的研究趋势和现状,旨在为国内的同类研究提供参考.

  19. Prevention of Post Traumatic Stress Disorder among Military Health Care Workers: A Systematic Review

    Science.gov (United States)

    2012-01-01

    applicability to the military healthcare provider. Comprehensive electronic search was performed utilizing MEDLINE, Cochrane Database, PubMed, CINAHL ( EBSCO ...Database PubMed, CINAHL ( EBSCO ), Health and Wellness Resource Center, Nursing and Allied Health Source, Applied Social Sciences Index (CSA), PsycARTICLES...prevention of PTSD among such an at risk group of workers. Methods A comprehensive search was performed of MEDLINE, Cochrane Database, Pub Med, CINAHL ( EBSCO

  20. AtPUB 19, a U-Box E3 Ubiquitin Ligase, Negatively Regulates Abscisic Acid and Drought Responses in Arabidopsis thaliana

    Institute of Scientific and Technical Information of China (English)

    Yong-Chang Liu; Yao-Rong Wu; Xia-He Huang; Jie Sun; Qi Xie

    2011-01-01

    Ubiquitination is an important protein post-translational modification,which is involved in various cellular processes in higher plants,and U-box E3 ligases play important roles in diverse functions in eukaryotes.Here,we describe the functions of Arabidopsis thaliana PUB19 (AtPUB19),which we demonstrated in an in vitro assay to encode a U-box type E3 ubiquitin ligase.AtPUB19 was up-regulated by drought,salt,cold,and abscisic acid (ABA).Down-regulation of AtPUB19led to hypersensitivity to ABA,enhanced ABA-induced stomatal closing,and enhanced drought tolerance,while AtPUB 19overexpression resulted in the reverse phenotypes.Molecular analysis showed that the expression levels of a number of ABA and stress marker genes were altered in both AtPUB 19 overexpressing and atpub 19-1 mutant plants.In summary,our data show that AtPUB19 negatively regulates ABA and drought responses in A.thaliana.

  1. The Arabidopsis U-box E3 Ubiquitin ligase PUB30 Negatively Regulates Salt Tolerance by Facilitating BRI1 KINASE INHIBITOR 1 (BKI1) Degradation.

    Science.gov (United States)

    Zhang, Ming; Zhao, Jinfeng; Li, Long; Gao, Yanan; Zhao, Linlin; Patil, Suyash Bhimgonda; Fang, Jingjing; Zhang, Wenhui; Yang, Yuhong; Li, Ming; Li, Xueyong

    2017-09-02

    The Arabidopsis U-box E3 ubiquitin (Ub) ligases play an important role in the ubiquitin/26S proteasome-mediated protein degradation pathway. Recently PUB30 has been reported to participate in the salt stress response during seed germination stage in ABA-independent manner, but the molecular mechanism remains to be elucidated. Here we displayed that the pub30 mutant was more tolerant to salt stress during seed germination, whereas the mutant of its closest homologue PUB31 showed mild sensitivity to salt stress. PUB30 exhibited E3 ubiquitin ligase activity in vitro. PUB30 specifically interacted with BRI1 KINASE INHIBITOR 1 (BKI1), a regulator playing dual roles in brassinosteroids (BRs) signaling, in vitro and in vivo. We found that BKI1 protein was ubiquitinated and degraded by the 26S proteasome. The degradation of BKI1 was slowed down in the pub30-1 mutant compared with that in the wild-type. The bki1 mutant was sensitive to salt whereas the transgenic plants overexpressing BKI1 showed salt tolerant phenotype. All these results indicate that PUB30 negatively regulates salt tolerance probably through regulating the degradation of BKI1 and BRs signaling in Arabidopsis. This article is protected by copyright. All rights reserved.

  2. Answers to questions posed during daily patient care are more likely to be answered by UpToDate than PubMed.

    Science.gov (United States)

    Hoogendam, Arjen; Stalenhoef, Anton F H; Robbé, Pieter F de Vries; Overbeke, A John P M

    2008-10-03

    UpToDate and PubMed are popular sources for medical information. Data regarding the efficiency of PubMed and UpToDate in daily medical care are lacking. The purpose of this observational study was to describe the percentage of answers retrieved by these information sources, comparing search results with regard to different medical topics and the time spent searching for an answer. A total of 40 residents and 30 internists in internal medicine working in an academic medical center searched PubMed and UpToDate using an observation portal during daily medical care. The information source used for searching and the time needed to find an answer to the question were recorded by the portal. Information was provided by searchers regarding the topic of the question, the situation that triggered the question, and whether an answer was found. We analyzed 1305 patient-related questions sent to PubMed and/or UpToDate between October 1, 2005 and March 31, 2007 using our portal. A complete answer was found in 594/1125 (53%) questions sent to PubMed or UpToDate. A partial or full answer was obtained in 729/883 (83%) UpToDate searches and 152/242 (63%) PubMed searches (P UpToDate answered more questions than PubMed on all major medical topics, but a significant difference was detected only when the question was related to etiology (P UpToDate and 291 seconds (SD 7) for PubMed. Specialists and residents in internal medicine generally use less than 5 minutes to answer patient-related questions in daily care. More questions are answered using UpToDate than PubMed on all major medical topics.

  3. Performance evaluation of unified medical language system®'s synonyms expansion to query PubMed

    Directory of Open Access Journals (Sweden)

    Griffon Nicolas

    2012-02-01

    Full Text Available Abstract Background PubMed is the main access to medical literature on the Internet. In order to enhance the performance of its information retrieval tools, primarily non-indexed citations, the authors propose a method: expanding users' queries using Unified Medical Language System' (UMLS synonyms i.e. all the terms gathered under one unique Concept Unique Identifier. Methods This method was evaluated using queries constructed to emphasize the differences between this new method and the current PubMed automatic term mapping. Four experts assessed citation relevance. Results Using UMLS, we were able to retrieve new citations in 45.5% of queries, which implies a small increase in recall. The new strategy led to a heterogeneous 23.7% mean increase in non-indexed citation retrieved. Of these, 82% have been published less than 4 months earlier. The overall mean precision was 48.4% but differed according to the evaluators, ranging from 36.7% to 88.1% (Inter rater agreement was poor: kappa = 0.34. Conclusions This study highlights the need for specific search tools for each type of user and use-cases. The proposed strategy may be useful to retrieve recent scientific advancement.

  4. Meshable: searching PubMed abstracts by utilizing MeSH and MeSH-derived topical terms.

    Science.gov (United States)

    Kim, Sun; Yeganova, Lana; Wilbur, W John

    2016-10-01

    Medical Subject Headings (MeSH(®)) is a controlled vocabulary for indexing and searching biomedical literature. MeSH terms and subheadings are organized in a hierarchical structure and are used to indicate the topics of an article. Biologists can use either MeSH terms as queries or the MeSH interface provided in PubMed(®) for searching PubMed abstracts. However, these are rarely used, and there is no convenient way to link standardized MeSH terms to user queries. Here, we introduce a web interface which allows users to enter queries to find MeSH terms closely related to the queries. Our method relies on co-occurrence of text words and MeSH terms to find keywords that are related to each MeSH term. A query is then matched with the keywords for MeSH terms, and candidate MeSH terms are ranked based on their relatedness to the query. The experimental results show that our method achieves the best performance among several term extraction approaches in terms of topic coherence. Moreover, the interface can be effectively used to find full names of abbreviations and to disambiguate user queries. https://www.ncbi.nlm.nih.gov/IRET/MESHABLE/ CONTACT: sun.kim@nih.gov Supplementary data are available at Bioinformatics online. © The Author 2016. Published by Oxford University Press.

  5. Isotypic Mn(II) and Fe(II) binuclear complexes of the ligand 5,6-bis-(pyridin-2-yl)-pyrazine-2,3-di-carb-oxy-lic acid.

    Science.gov (United States)

    Alfonso, Monserrat; Stoeckli-Evans, Helen

    2016-10-01

    The title isotypic complexes, bis-[μ-5,6-bis-(pyridin-2-yl)pyrazine-2,3-di-carboxylato]-κ(4)N(1),O(2),N(6):O(3);κ(4)O(3):N(1),O(2),N(6)-bis-[di-aqua-manganese(II)] tetra-hydrate, [Mn2(C16H8N4O4)2(H2O)4]·4H2O, (I), and bis-[μ-5,6-bis-(pyridin-2-yl)pyrazine-2,3-di-carboxyl-ato]-κ(4)N(1),O(2),N(6):O(3);κ(4)O(3):N(1),O(2),N(6)-bis-[di-aqua-iron(II)] tetrahydrate, [Fe2(C16H8N4O4)2(H2O)4]·4H2O, (II), are, respectively, the mangan-ese(II) and iron(II) complexes of the ligand 5,6-bis-(pyridin-2-yl)-pyrazine-2,3-di-carb-oxy-lic acid. The complete mol-ecule of each complex is generated by inversion symmetry. Each metal ion is coordinated by a pyrazine N atom, a pyridine N atom, two carboxyl-ate O atoms, one of which is bridging, and two water O atoms. The metal atoms have MN2O4 coordination geometries and the complexes have a cage-like structure. In the crystals of both compounds, the complexes are linked by O-H⋯O and O-H⋯N hydrogen bonds involving the coordinating water mol-ecules, forming chains along [100]. These chains are linked by O-H⋯O hydrogen bonds involving the non-coordinating water mol-ecules, forming layers parallel to (011). The layers are linked by pairs of C-H⋯O hydrogen bonds and offset π-π inter-actions, so forming a hydrogen-bonded three-dimensional framework.

  6. Geospatial health

    DEFF Research Database (Denmark)

    Utzinger, Jürg; Rinaldi, Laura; Malone, John B.

    2011-01-01

    Geospatial Health is an international, peer-reviewed scientific journal produced by the Global Network for Geospatial Health (GnosisGIS). This network was founded in 2000 and the inaugural issue of its official journal was published in November 2006 with the aim to cover all aspects of geographical...... information system (GIS) applications, remote sensing and other spatial analytic tools focusing on human and veterinary health. The University of Naples Federico II is the publisher, producing two issues per year, both as hard copy and an open-access online version. The journal is referenced in major...... databases, including CABI, ISI Web of Knowledge and PubMed. In 2008, it was assigned its first impact factor (1.47), which has now reached 1.71. Geospatial Health is managed by an editor-in-chief and two associate editors, supported by five regional editors and a 23-member strong editorial board...

  7. PubMed,ISI-Medline,Google Scholar检索性能对比测评%The Evaluation on the Retrieval Performance of PubMed, ISI-Medline and Google Scholar

    Institute of Scientific and Technical Information of China (English)

    欧荣

    2009-01-01

    PubMed,ISI-Medline,Google Scholar是科研人员查找生物医学文献使用较多的检索工具.从检索范围、检索字段、检索方式、检索结果处理、个性化服务等角度对3者进行比较分析,结果表明3者均具有不可替换的优势,同时也存在各自不足,科研人员需根据需求选择相应的检索工具,制定适宜的检索策略.

  8. Comparison of the Strengths and Weaknesses of PubMed,Scopus,Web of Science and Google Scholar%比较PubMed,Scopus,Web of Science和Google Scholar的优点和缺点

    Institute of Scientific and Technical Information of China (English)

    王丹

    2010-01-01

    PubMed,Scopus,Web of Science和Google Scholar是当代生物医学科学信息最流行的资源工具,本文旨在比较这四种数据库在特定生物医学主题中检索信息、更新引文分析的区别.用数据库的官方网页在期刊涵盖的范围、用于搜索的实用程序及其限制、更新频率、引文特征等进行比较.用实例对关键词搜索来评估这些数据库检索结果的特点,并检索特定的一篇文章查看其引文特征.

  9. A statistical analysis and perspective of headache-related papers covered in 2011 PubMed%2011年PubMed收录头痛相关文献统计分析与展望

    Institute of Scientific and Technical Information of China (English)

    张明洁; 于生元; 初炳倩; 代维

    2013-01-01

    Objective To investigate the distribution and hot spots of literatures on headache by bibliometric analysis in order to provide reference for further study.Methods Literatures that contained headache or migraine in text words published in 2011 in PubMed databases (www.ncbi.nlm.nih.gov/ Pubmed) were searched.Journals,countries and subjects were bibliometrically analysed.Results There were 3683 papers involved to headache published in PubMed in 2011,of which 1527 papers were on headache research.The number of papers on headache research published by USA was the most followed by Italy and Germany (USA 23.25%,Italy 10.74%,Germany 5.83%).The mainly studied subjects were therapy(29.60%),pathophysiology (18.66%) and etiology (16.31%).14.86% papers published in Cephalalgia,which is one of the most important journals,reported negative results.Conclusion The emphasis of headache research was on migraine.Therapy,pathophysiology and etiology were the hot spot.Literatures with negative result attracted authors to give the more attention.%目的 研究2011年PubMed收录头痛相关文献的分布和热点,为该领域进一步深入研究提供参考.方法 检索PubMed数据库2011年收录的头痛相关文献,应用文献计量学方法对论文发表的期刊、国家和主题进行统计分析.结果 2011年以头痛为研究主题的文献共1527篇,美国、意大利、德国发文量位居前三,研究热点主要集中于治疗(29.60%)、病理生理学(18.66%)、病因学(16.31%)等几个方面,其中偏头痛为研究重点(54.09%),Cephalalgia为重点期刊,其发表的阴性结果的文章占论著总数的14.86%.结论 当前头痛疾患的研究主要集中在偏头痛方面,研究热点主要集中于治疗、病理生理学、病因学等方面;较高比例的阴性结果文章发表值得广大作者重视.

  10. Unleashed numerical daemons in our pub: Is poor numerical implementation of hydrologic models hurting the Predictions in Ungauged Basins initiative?

    Science.gov (United States)

    Clark, Martyn; Kavetski, Dmitri

    2010-05-01

    Much of the research in the PUB initiative is focused on the analysis and interpretation of model results in well instrumented watersheds, in order to inform appropriate model structures and parameter values for use in ungauged basins. However, many of the models used in PUB share a common characteristic: poor numerical implementation. It is likely that many published conclusions, including (i) parameter sensitivity, optima and uncertainty estimates, and, more disconcertingly, (ii) the interpretation of hydrologic model output to gain insights into internal catchment dynamics, including the relative significance and behavior of different processes, may be questionable due to numerical artifacts introduced by unreliable time stepping schemes. Such lack of attention to numerical schemes has almost certainly hindered progress in the PUB initiative. Here, we comprehensively evaluate several classes of time stepping schemes in terms of numerical fidelity, computational efficiency, and impact on model sensitivity analysis, calibration and prediction. Extensive numerical experiments are carried out using 8 distinct time stepping algorithms and 6 different conceptual hydrological models, applied in the densely gauged experimental Mahurangi catchment as well as in 12 MOPEX basins with diverse physical characteristics and hydroclimatic regimes. Results show that numerical errors of uncontrolled time stepping schemes, which remain widely used in hydrology, routinely dwarf the structural errors of the model conceptualization. This has serious implications for model analysis and predictive use, including inconsistent inferences of parameters and internal states even if the calibrated streamflow predictions are similar. Even when numerical errors allow "getting the right result for the wrong reason", they make the model unduly fragile in predictive mode, as evidenced in validation tests. The extensive analyses in this paper indicate that these deformations are not rare isolated

  11. 基于NCBI开放接口的学科信息平台PubMed检索服务功能实现

    Institute of Scientific and Technical Information of China (English)

    苏叶; 黄文

    2014-01-01

    作为全球最大的网络生物医学文献数据库,美国PubMed在生物医学研究领域有着不可替代的作用。生物医学领域的科研人员已经习惯于利用PubMed查找所需要的信息资源。该文简要介绍了NCBI提供的Web Serv-ice接口功能,以及如何利用该接口在将PubMed检索服务内嵌到学科服务平台中,并将PubMed服务与图书馆的文献传递服务进行了尝试性的集成。

  12. Using the PubMatrix literature-mining resource to accelerate student-centered learning in a veterinary problem-based learning curriculum.

    Science.gov (United States)

    David, John; Irizarry, Kristopher J L

    2009-01-01

    Problem-based learning (PBL) creates an atmosphere in which veterinary students must take responsibility for their own education. Unlike a traditional curriculum where students receive discipline-specific information by attending formal lectures, PBL is designed to elicit self-directed, student-centered learning such that each student determines (1) what he/she does not know (learning issues), (2) what he/she needs to learn, (3) how he/she will learn it, and (4) what resources he/she will use. One of the biggest challenges facing students in a PBL curriculum is efficient time management while pursuing learning issues. Bioinformatics resources, such as the PubMatrix literature-mining tool, allow access to tremendous amounts of information almost instantaneously. To accelerate student-centered learning it is necessary to include resources that enhance the rate at which students can process biomedical information. Unlike using the PubMed interface directly, the PubMatrix tool enables users to automate queries, allowing up to 1,000 distinct PubMed queries to be executed per single PubMatrix submission. Users may submit multiple PubMatrix queries per session, resulting in the ability to execute tens of thousands of PubMed queries in a single day. The intuitively organized results, which remain accessible from PubMatrix user accounts, enable students to rapidly assimilate and process hundreds of thousands of individual publication records as they relate to the student's specific learning issues and query terms. Subsequently, students can explore substantially more of the biomedical publication landscape per learning issue and spend a greater fraction of their time actively engaged in resolving their learning issues.

  13. Quantification of indoor and outdoor volatile organic compounds (VOCs) in pubs and cafés in Pamplona, Spain

    Science.gov (United States)

    Parra, M. A.; Elustondo, D.; Bermejo, R.; Santamaría, J. M.

    Indoor and outdoor concentrations of volatile organic compounds (VOCs) were measured in 30 pubs and cafés (13 smoking, 13 non-smoking and 4 mixed atmospheres) in Pamplona city, Spain. The samples were obtained using a sampling pocket pump connected to stainless steel tubes filled with Tenax TA, and subsequently analysed by means of GC-MS coupled to a thermal desorption unit. The levels registered were found to be generally higher indoors. Smoking, cleaning products and the entrance of outdoor pollutants were identified as the main sources of these compounds, the later being especially relevant in non-smoking areas. BTEX concentrations were higher during the winter months and higher in smoking areas also.

  14. Bibliometric analysis of the Korean Journal of Parasitology: measured from SCI, PubMed, Scopus, and Synapse databases.

    Science.gov (United States)

    Lee, Choon Shil

    2009-10-01

    The Korean Journal of Parasitology (KJP) is the official journal of the Korean Society for Parasitology which is celebrating its 50th anniversary in 2009. To assess the contributions and achievements of the KJP, bibliometric analysis was conducted based on the citation data retrieved from 4 major databases; SCI, PubMed, Synapse, and Scopus. It was found that the KJP articles were constantly cited by the articles published in major international journals represented in these databases. More than 60% of 1,370 articles published in the KJP from 1963 to June 2009 were cited at least once by SCI articles. The overall average times cited by SCI articles are 2.6. The rate is almost 3 times higher for the articles published in the last 10 years compared to 1.0 for the articles of the 1960s. The SCI journal impact factor for 2008 is calculated as 0.871. It is increasing and it is expected to increase further with the introduction of the KJP in the database in 2008. The more realistic h-indices were measured from the study data set covering all the citations to the KJP; 17 for SCI, 6 for PubMed, 19 for Synapse, and 17 for Scopus. Synapse extensively picked up the citations to the earlier papers not retrievable from the other 3 databases. It identified many papers published in the 1960s and in the 1980s which have been cited heavily, proving the central role of the KJP in the dissemination of the important research findings over the last 5 decades.

  15. PubMed search strategies for the identification of etiologic associations between hypothalamic-pituitary disorders and other medical conditions.

    Science.gov (United States)

    Guaraldi, Federica; Grottoli, Silvia; Arvat, Emanuela; Mattioli, Stefano; Ghigo, Ezio; Gori, Davide

    2013-12-01

    Biomedical literature has enormously grown in the last decades and become broadly available through online databases. Ad-hoc search methods, created on the basis of research field and goals, are required to enhance the quality of searching. Aim of this study was to formulate efficient, evidence-based PubMed search strategies to retrieve articles assessing etiologic associations between a condition of interest and hypothalamic-pituitary disorders (HPD). Based on expert knowledge, 17 MeSH (Medical Subjects Headings) and 79 free terms related to HPD were identified to search PubMed. Using random samples of abstracts retrieved by each term, we estimated the proportion of articles containing pertinent information and formulated two strings (one more specific, one more sensitive) for the detection of articles focusing on the etiology of HPD, that were then applied to retrieve articles identifying possible etiologic associations between HPD and three diseases (malaria, LHON and celiac disease) considered not associated to HPD, and define the number of abstracts needed to read (NNR) to find one potentially pertinent article. We propose two strings: one sensitive string derived from the combination of articles providing the largest literature coverage in the field and one specific including combined terms retrieving ≥40% of potentially pertinent articles. NNR were 2.1 and 1.6 for malaria, 3.36 and 2.29 for celiac disease, 2.8 and 2.2 for LHON, respectively. For the first time, two reliable, readily applicable strings are proposed for the retrieval of medical literature assessing putative etiologic associations between HPD and other medical conditions of interest.

  16. MeSHy: Mining unanticipated PubMed information using frequencies of occurrences and concurrences of MeSH terms.

    Science.gov (United States)

    Theodosiou, T; Vizirianakis, I S; Angelis, L; Tsaftaris, A; Darzentas, N

    2011-12-01

    PubMed is the most widely used database of biomedical literature. To the detriment of the user though, the ranking of the documents retrieved for a query is not content-based, and important semantic information in the form of assigned Medical Subject Headings (MeSH) terms is not readily presented or productively utilized. The motivation behind this work was the discovery of unanticipated information through the appropriate ranking of MeSH term pairs and, indirectly, documents. Such information can be useful in guiding novel research and following promising trends. A web-based tool, called MeSHy, was developed implementing a mainly statistical algorithm. The algorithm takes into account the frequencies of occurrences, concurrences, and the semantic similarities of MeSH terms in retrieved PubMed documents to create MeSH term pairs. These are then scored and ranked, focusing on their unexpectedly frequent or infrequent occurrences. MeSHy presents results through an online interactive interface facilitating further manipulation through filtering and sorting. The results themselves include the MeSH term pairs, along with MeSH categories, the score, and document IDs, all of which are hyperlinked for convenience. To highlight the applicability of the tool, we report the findings of an expert in the pharmacology field on querying the molecularly-targeted drug imatinib and nutrition-related flavonoids. To the best of our knowledge, MeSHy is the first publicly available tool able to directly provide such a different perspective on the complex nature of published work. Implemented in Perl and served by Apache2 at http://bat.ina.certh.gr/tools/meshy/ with all major browsers supported. Copyright © 2011 Elsevier Inc. All rights reserved.

  17. "Si pudiera pagaría": Estudio sobre la accesibilidad simbólica de las mujeres usuarias pobres del AMBA a los servicios asistenciales estatales "If i could i would pay": Research about symbolic access of poor women users from the AMBA to the state health services

    Directory of Open Access Journals (Sweden)

    Yamila Comes

    2005-12-01

    Full Text Available Este trabajo constituye un avance de la Beca de Doctorado UBACyT de la Lic. Comes (Directora de Beca: Lic. Alicia Stolkiner, Directora de Tesis Dra. Dora Barrancos. Forma parte del proyecto de Investigación "Reforma en salud en la Ciudad de Buenos Aires: Modificaciones en las representaciones y prácticas de trabajadores y usuarios NBI del sector" (Directora Lic. Alicia Stolkiner. El objetivo consiste en describir la accesibilidad simbólica de las mujeres pobres del AMBA a los servicios asistenciales tomando como trazadoras de dicho concepto las ideas y representaciones sobre la gratuidad en la atención. Metodología: Entrevistas semiestructuradas (34 en base a un muestreo teórico. Conclusiones: las representaciones rastreadas sobre la gratuidad de la atención, entendida como no arancelamiento de los hospitales estatales se acercan conceptualmente a definiciones que niegan la existencia del derecho a la atención de la Salud y ubican la atención para pobres como "deber de beneficencia". También expresan ideas de derecho a la salud restringido para poblaciones sin recursos. Estas representaciones serian congruentes con lo que expresan los Organismos Internacionales que han participado de la Reforma Sanitaria mas que con lo que emana de la Constitución Nacional acerca de los Derechos Humanos. Por lo tanto se señala que existen barreras de accesibilidad simbólica a los servicios de salud del AMBA.This work is an advance of Comes Yamila PHd fellowship financed by UBACyT. (Fellowship Director: Lic. Alicia Stolkiner, Thesis Director Dra. Dora Barrancos. It is framed from the investigation project titled: "Reform in Health care Services of Buenos Aires: changes in the representations and practices of workers and poor users of the sector" (Director Lic. Alicia Stolkiner. It's aim is to describe nada analyze the symbolic access of poor women from the AMBA to health services. The social representations of free attention in public hospitals is

  18. Kwarteng Frimpong.pub

    African Journals Online (AJOL)

    User

    of the Asante Akyem South District Assembly (AASDA) in managing the implementation of its development plans. .... ity in mobilising, organising and managing resources at the ..... toring team also had no monitoring plan and timetable.

  19. osei boboie.1.pub

    African Journals Online (AJOL)

    User

    market in large quantities, with varied colour ranges to identify their suitability as effective col- ourants on ... This experiment was subdivided into three parts where various techniques for applying dyes were used. .... The prepared dye solution was poured into ... turbing their natural properties such as flexibil- ity, tensile ...

  20. Physical Uncertainty Bounds (PUB)

    Energy Technology Data Exchange (ETDEWEB)

    Vaughan, Diane Elizabeth [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Preston, Dean L. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-03-19

    This paper introduces and motivates the need for a new methodology for determining upper bounds on the uncertainties in simulations of engineered systems due to limited fidelity in the composite continuum-level physics models needed to simulate the systems. We show that traditional uncertainty quantification methods provide, at best, a lower bound on this uncertainty. We propose to obtain bounds on the simulation uncertainties by first determining bounds on the physical quantities or processes relevant to system performance. By bounding these physics processes, as opposed to carrying out statistical analyses of the parameter sets of specific physics models or simply switching out the available physics models, one can obtain upper bounds on the uncertainties in simulated quantities of interest.

  1. Advancing PubMed?

    DEFF Research Database (Denmark)

    Wildgaard, Lorna Elizabeth; Lund, Haakon

    2016-01-01

    Purpose Systematic reviews of biomedical literature are used to inform patient treatment. Yet the acquisition of relevant literature is proving increasingly challenging due to the large volume of information that needs to be searched, filtered and collocated. There is a need to improve the effici......Med remains the superior provider for searching, identifying, and exporting biomedical literature for systematic reviews. Originality/value The work contributes to the discussion of how librarians can help researchers navigate the biomedical literature in systematic reviews....

  2. Genome-Wide Identification of Soybean U-Box E3 Ubiquitin Ligases and Roles of GmPUB8 in Negative Regulation of Drought Stress Response in Arabidopsis.

    Science.gov (United States)

    Wang, Ning; Liu, Yaping; Cong, Yahui; Wang, Tingting; Zhong, Xiujuan; Yang, Shouping; Li, Yan; Gai, Junyi

    2016-06-01

    Plant U-box (PUB) E3 ubiquitin ligases play important roles in hormone signaling pathways and response to abiotic stresses, but little is known about them in soybean, Glycine max. Here, we identified and characterized 125 PUB genes from the soybean genome, which were classified into eight groups according to their protein domains. Soybean PUB genes (GmPUB genes) are broadly expressed in many tissues and are a little more abundant in the roots than in the other tissues. Nine GmPUB genes, GmPUB1-GmPUB9, showed induced expression patterns by drought, and the expression of GmPUB8 was also induced by exogenous ABA and NaCl. GmPUB8 was localized to post-Golgi compartments, interacting with GmE2 protein as demonstrated by yeast two-hybrid (Y2H) and bimolecular fluorescence complementation (BiFC) experiments, and showed E3 ubiquitin ligase activity by in vitro ubiquitination assay. Heterogeneous overexpression of GmPUB8 in Arabidopsis showed decreased drought tolerance, enhanced sensitivity with respect to osmotic and salt stress inhibition of seed germination and seedling growth, and inhibited ABA- and mannitol-mediated stomatal closure. Eight drought stress-related genes were less induced in GmPUB8-overexpressing Arabidopsis after drought treatment compared with the wild type and the pub23 mutant. Taken together, our results suggested that GmPUB8 might negatively regulate plant response to drought stress. In addition, Y2H and BiFC showed that GmPUB8 interacted with soybean COL (CONSTANS LIKE) protein. GmPUB8-overexpressing Arabidopsis flowered earlier under middle- and short-day conditions but later under long-day conditions, indicating that GmPUB8 might regulate flowering time in the photoperiod pathway. This study helps us to understand the functions of PUB E3 ubiquitin ligases in soybean.

  3. Metodologies per l'estudi de compostos fenòlics i alcaloides en el cacau (theobroma cacao) i la garrofa (ceratonia siliqua L.): bextracció, caracterització i avaluació de la digestibilitat en model in-vitro

    OpenAIRE

    Ortega Olivé, Nàdia

    2010-01-01

    Actualment hi ha un especial interès pels compostos fenòlics dels aliments en àmbits de la nutrició, salut i medicina en base a diferents evidències que suggereixen que poden actuar com a potents antioxidants i/o moduladors de funcions biològiques claus en els mamífers. Paral·lelament, hi ha una demanda per part dels consumidors en quant a la informació dels aliments que s'ingereix, de les necessitats nutricionals així com de la millora de salut. Tots aquest conceptes juntament amb la definic...

  4. Menopause: MedlinePlus Health Topic

    Science.gov (United States)

    ... Health) ClinicalTrials.gov: Premenopause (National Institutes of Health) Journal Articles References and abstracts from MEDLINE/PubMed (National Library of Medicine) Article: Integrative Women's Health. Article: Tai Chi Exercise for the Quality of Life in a... Article: Effect of soybean protein on ...

  5. Pub1p C-terminal RRM domain interacts with Tif4631p through a conserved region neighbouring the Pab1p binding site.

    Directory of Open Access Journals (Sweden)

    Clara M Santiveri

    Full Text Available Pub1p, a highly abundant poly(A+ mRNA binding protein in Saccharomyces cerevisiae, influences the stability and translational control of many cellular transcripts, particularly under some types of environmental stresses. We have studied the structure, RNA and protein recognition modes of different Pub1p constructs by NMR spectroscopy. The structure of the C-terminal RRM domain (RRM3 shows a non-canonical N-terminal helix that packs against the canonical RRM fold in an original fashion. This structural trait is conserved in Pub1p metazoan homologues, the TIA-1 family, defining a new class of RRM-type domains that we propose to name TRRM (TIA-1 C-terminal domain-like RRM. Pub1p TRRM and the N-terminal RRM1-RRM2 tandem bind RNA with high selectivity for U-rich sequences, with TRRM showing additional preference for UA-rich ones. RNA-mediated chemical shift changes map to β-sheet and protein loops in the three RRMs. Additionally, NMR titration and biochemical in vitro cross-linking experiments determined that Pub1p TRRM interacts specifically with the N-terminal region (1-402 of yeast eIF4G1 (Tif4631p, very likely through the conserved Box1, a short sequence motif neighbouring the Pab1p binding site in Tif4631p. The interaction involves conserved residues of Pub1p TRRM, which define a protein interface that mirrors the Pab1p-Tif4631p binding mode. Neither protein nor RNA recognition involves the novel N-terminal helix, whose functional role remains unclear. By integrating these new results with the current knowledge about Pub1p, we proposed different mechanisms of Pub1p recruitment to the mRNPs and Pub1p-mediated mRNA stabilization in which the Pub1p/Tif4631p interaction would play an important role.

  6. Overexpression of a stress-responsive U-box protein gene VaPUB affects the accumulation of resistance related proteins in Vitis vinifera 'Thompson Seedless'.

    Science.gov (United States)

    Jiao, Li; Zhang, Yali; Lu, Jiang

    2017-03-01

    Many U-box proteins have been identified and characterized as important factors against environmental stresses such as chilling, heat, salinity and pathogen attack in plant. Our previous research reported the cloning of a novel U-box protein gene VaPUB from Vitis amurensis 'Zuoshanyi' grape and suggested a function of it in related to cold stress in the model plant Arabidopsis system. In this study, the role of VaPUB in response to biotic and abiotic stress was further analyzed in the homologous grapevine system by studying the transcript regulation and the protein accumulation in VaPUB transgenic vines. The expression analysis assay shown that VaPUB was significantly up-regulated 6 h after cold treatment and as early as 2 h post inoculation with Plasmopara viticola, a pathogen causing downy mildew disease in grapevine. Over-expressing VaPUB in V. Vinifera 'Thompson Seedless' affected the microstructure of leaves. The proteome assay shown that the accumulation of pathogenesis-related protein PR10 and many proteins involved in carbon and energy metabolism, oxidation reaction and protein metabolism were significantly altered in transgenic vines. In comparison with wild type plants, the expression level of PR10 family genes was significantly decreased in VaPUB transgenic vines under P. viticola treatment or cold stress. Results from this study showed that the U-box protein gene PUB quickly responded to both biotic stress and abiotic stress and significantly influenced the accumulation of resistance related proteins in grapevine. Copyright © 2016. Published by Elsevier Masson SAS.

  7. Countries’ Biomedical Publications and Attraction Scores. A PubMed-based assessment [v2; ref status: indexed, http://f1000r.es/5q4

    Directory of Open Access Journals (Sweden)

    Qinyi Xu

    2015-08-01

    Full Text Available Studying publication volumes at the country level is key to understanding and improving a country’s research system. PubMed is a public search engine of publications in all life sciences areas. Here, we show how this search engine can be used to assess the outputs of life science-related research by country. We have measured the numbers of publications during different time periods based on the country of affiliation of the first authors. Moreover, we have designed scores, which we have named Attraction Scores, to appraise the relative focus either toward particular types of studies, such as clinical trials or reviews, or toward specific research areas, such as public health and pharmacogenomics, or toward specific topics, for instance embryonic stem cells; we have also investigated a possible use of these Attraction Scores in connection with regulatory policies. We have weighed the statistics against general indicators such as country populations and gross domestic products (GDP. During the 5-year period 2008-2012, the United States was the country with the highest number of publications and Denmark the one with the highest number of publications per capita. Among the 40 countries with the highest GDPs, Israel had the highest publications-to-GDP ratio. Among the 20 countries with the most publications, Japan had the highest Attraction Score for induced pluripotent stem (iPS cells and Italy the highest proportion of review publications. More than 50% of publications in English were from countries in which English is not the primary language. We show an assorted and extensive collection of rankings and charts that will inform scholars and policymakers in studying and improving the research systems both at the national and international level.

  8. The Medicago truncatula E3 Ubiquitin Ligase PUB1 Interacts with the LYK3 Symbiotic Receptor and Negatively Regulates Infection and Nodulation[W][OA

    Science.gov (United States)

    Mbengue, Malick; Camut, Sylvie; de Carvalho-Niebel, Fernanda; Deslandes, Laurent; Froidure, Solène; Klaus-Heisen, Dörte; Moreau, Sandra; Rivas, Susana; Timmers, Ton; Hervé, Christine; Cullimore, Julie; Lefebvre, Benoit

    2010-01-01

    LYK3 is a lysin motif receptor-like kinase of Medicago truncatula, which is essential for the establishment of the nitrogen-fixing, root nodule symbiosis with Sinorhizobium meliloti. LYK3 is a putative receptor of S. meliloti Nod factor signals, but little is known of how it is regulated and how it transduces these symbiotic signals. In a screen for LYK3-interacting proteins, we identified M. truncatula Plant U-box protein 1 (PUB1) as an interactor of the kinase domain. In planta, both proteins are localized and interact in the plasma membrane. In M. truncatula, PUB1 is expressed specifically in symbiotic conditions, is induced by Nod factors, and shows an overlapping expression pattern with LYK3 during nodulation. Biochemical studies show that PUB1 has a U-box–dependent E3 ubiquitin ligase activity and is phosphorylated by the LYK3 kinase domain. Overexpression and RNA interference studies in M. truncatula show that PUB1 is a negative regulator of the LYK3 signaling pathway leading to infection and nodulation and is important for the discrimination of rhizobia strains producing variant Nod factors. The potential role of PUB E3 ubiquitin ligases in controlling plant–microbe interactions and development through interacting with receptor-like kinases is discussed. PMID:20971894

  9. 1-{[4'-(1H-1,2,4-Triazol-2-ium-1-ylmeth-yl)biphenyl-4-yl]meth-yl}-1H-1,2,4-triazol-2-ium bis-(3-carb-oxy-5-iodo-benzoate)-5-iodo-benzene-3,5-dicarb-oxy-lic acid-water (1/2/2).

    Science.gov (United States)

    Zhang, Kou-Lin; Deng, Ye; Ng, Seik Weng

    2012-05-01

    The neutral carb-oxy-lic acid mol-ecule and the carboxyl-ate anion in the title compound, C(18)H(18)N(6) (2+)·2C(8)H(4)IO(4) (-)·2C(8)H(5)IO(4)·2H(2)O, are both nearly planar (r.m.s. deviations = 0.034 and 0.045 Å, respectively). In the cation, the mid-point of the C-C bond linking the two benzene rings lies on a center of inversion, and the triazole ring is approximately perpendicular to the adjacent benzene ring [dihedral angle = 83.2 (3)°]. In the crystal, the cations, anions, carb-oxy-lic acid and lattice water mol-ecules are linked by N-H⋯O, O-H⋯N and O-H⋯O hydrogen bonds, generating a ribbon running along [1-10]. The crystal studied was a non-merohedral twin with the components in a 51.2 (1):48.8 (1) ratio.

  10. pubmed.mineR: an R package with text-mining algorithms to analyse PubMed abstracts.

    Science.gov (United States)

    Rani, Jyoti; Shah, A B Rauf; Ramachandran, Srinivasan

    2015-10-01

    The PubMed literature database is a valuable source of information for scientific research. It is rich in biomedical literature with more than 24 million citations. Data-mining of voluminous literature is a challenging task. Although several text-mining algorithms have been developed in recent years with focus on data visualization, they have limitations such as speed, are rigid and are not available in the open source. We have developed an R package, pubmed.mineR, wherein we have combined the advantages of existing algorithms, overcome their limitations, and offer user flexibility and link with other packages in Bioconductor and the Comprehensive R Network (CRAN) in order to expand the user capabilities for executing multifaceted approaches. Three case studies are presented, namely, 'Evolving role of diabetes educators', 'Cancer risk assessment' and 'Dynamic concepts on disease and comorbidity' to illustrate the use of pubmed.mineR. The package generally runs fast with small elapsed times in regular workstations even on large corpus sizes and with compute intensive functions. The pubmed.mineR is available at http://cran.rproject. org/web/packages/pubmed.mineR.

  11. pubmed.mineR: An R package with text-mining algorithms to analyse PubMed abstracts

    Indian Academy of Sciences (India)

    Jyoti Rani; Ab Rauf Shah; Srinivasan Ramachandran

    2015-10-01

    The PubMed literature database is a valuable source of information for scientific research. It is rich in biomedical literature with more than 24 million citations. Data-mining of voluminous literature is a challenging task. Although several text-mining algorithms have been developed in recent years with focus on data visualization, they have limitations such as speed, are rigid and are not available in the open source. We have developed an R package, pubmed.mineR, wherein we have combined the advantages of existing algorithms, overcome their limitations, and offer user flexibility and link with other packages in Bioconductor and the Comprehensive R Network (CRAN) in order to expand the user capabilities for executing multifaceted approaches. Three case studies are presented, namely, `Evolving role of diabetes educators', `Cancer risk assessment' and `Dynamic concepts on disease and comorbidity' to illustrate the use of pubmed.mineR. The package generally runs fast with small elapsed times in regular workstations even on large corpus sizes and with compute intensive functions. The pubmed.mineR is available at http://cran.r- project.org/web/packages/pubmed.mineR.

  12. Cancer--Living with Cancer: MedlinePlus Health Topic

    Science.gov (United States)

    ... Clinical Trials ClinicalTrials.gov: Cancer and Quality of Life (National Institutes of Health) Journal Articles References and abstracts from MEDLINE/PubMed (National Library of Medicine) Article: Older people's experiences of cancer pain: a ...

  13. PubMed und LinkOut als Wegweiser zu Printbeständen in der Universitätsbibliothek der Medizinischen Universität Wien / PubMed and LinkOut as guidepost to print holding on the university library of the Medical University of Vienna

    Directory of Open Access Journals (Sweden)

    Dollfuß, Helmut

    2009-09-01

    Full Text Available In the area of electronic literature research PubMed is one of the most important literature data bases. In the course of our project selected print holdings on medical journals of the university library of the medical university Vienna were integrated in PubMed. Now scientists, lecturers, students, library staff and other interested persons have an easier access via PubMed to the comprehensive print holdings of medical journals of the university library, as well as some of their branch libraries.

  14. Access of primary and secondary literature by health personnel in an academic health center: implications for open access

    National Research Council Canada - National Science Library

    Maggio, Lauren A; Steinberg, Ryan M; Moorhead, Laura; O'Brien, Bridget; Willinsky, John

    2013-01-01

    The research sought to ascertain the types and quantity of research evidence accessed by health personnel through PubMed and UpToDate in a university medical center over the course of a year in order...

  15. 利用关系数据库实现对PubMed中RSS定制服务的统一管理

    Institute of Scientific and Technical Information of China (English)

    王刚

    2008-01-01

    RSS是一种描述和同步网站内容的格式,它是XML的一种形式.作为一个生物医学专业文献数据库服务网站,PubMed也开始提供RSS服务.本文介绍了如何将PubMed中RSS定制服务结果这种XML格式的文档通过Dietz编码存储到本地关系型数据库中进行管理,这样用户可以通过对本地数据库进行访问便会得到PubMed所提供的定制服务.

  16. Producción científica española en obesidad a través de PubMed (1988-2007 Spanish scientific production in obesity research published in PubMed (1988-2007

    Directory of Open Access Journals (Sweden)

    Jesús Vioque

    2010-06-01

    Full Text Available Objetivo: Analizar la producción científica española sobre obesidad en PubMed durante dos décadas (1988-2007 y contextualizarla en el marco de la Unión Europea. Métodos: Se realizó un estudio bibliométrico a través de la base de datos MEDLINE en PubMed mediante la búsqueda de «obesity» en MeSH, estimando las tendencias del número de publicaciones anuales mediante análisis de regresión. Resultados: Se recopilaron 50.120 documentos sobre obesidad, y 1.407 (2,8% de la producción mundial eran de autores españoles. España fue el quinto país con más documentos de la Unión Europea (8,1%. El 69,1% (n=932 estaban publicados en inglés. El crecimiento medio anual fue del 15%, pasando de 91 documentos en el primer quinquenio a 702 en el último. La especialidad más frecuente del primer firmante fue endocrinología, con 279 (22,8% documentos, seguida de fisiología-nutrición-bromatología con 203 (16,6% y bioquímica con 161 (13,2%. Medicina Clínica con 83 (6,1%, Obesity Surgery con 79 (5,8%, International Journal of Obesity con 73 (5,3% y Nutrición Hospitalaria con 59 (4,3% fueron las revistas con mayor número de documentos. Las comunidades autónomas más productoras fueron Cataluña (n=338; 24,9%, Madrid (n=286; 20,6% y Navarra (n=159; 11,7%. Las instituciones más productivas fueron los hospitales, con 708 (52,1% documentos, y las universidades, con 521 (38,5% documentos. Conclusiones: La investigación sobre obesidad en España ha crecido en los últimos 20 años y ha supuesto una aportación importante en el conjunto de la Unión Europea. La mitad de las publicaciones españolas se hicieron en revistas extranjeras y procedían predominantemente de hospitales y universidades.Objective: To analyse Spanish scientific research output related to obesity during a 20-year period from 1988 to 2007 into context with the European Union productivity Methods: The bibliometric study was based on research of the MEDLINE database in Pub

  17. A bibliometric analysis on research of fungal bioiflm from PubMed database%基于PubMed数据库医学真菌生物膜研究文献计量学分析

    Institute of Scientific and Technical Information of China (English)

    廖勇; 吕雪莲; 唐庆龙; 敖俊红; 杨蓉娅

    2015-01-01

    ObjectiveTo analyze the status quo of and review the research of fungal bioiflm worldwide by an overview of related literatures from PubMed, so as to provide ideas and basis for further research.MethodsMedical literatures on the research of fungal bioiflm in PubMed database were analyzed by using bibliometric tools such as Thomson data analyzer. The distributions of years, nations, journals, and currently hot topics on fungal bioiflm, and top-20 cited papers were analyzed.ResultsThe number of the papers published every year on fungal bioiflm was stable from 1981 to now. United States and Europe had leading advantages in this ifeld. The journal published the most papers of fungal bioiflm was American and European journals. Three of the top-10 authors of the most publications came from center for medical mycology, department of dermatology, university hospitals of cleveland, case western reserve university, which illustrates these research institutes in a leadership position in this ifeld. Researches focused on formation of medical fungal bioiflm, as well as its interaction with antifungal medicine and basis of this virulence related genes and proteins. The trend of citation analysis and qualifying contributions to the literature has some consistency. Researches in China are mainly from Hong Kong and Beijing, but there is an obvious gap between China and Europe or America.ConclusionUnited States and Europe are the leaders in this ifeld. The numbers and citation rates of the papers from China in this ifeld have been increasing in recent 5 years. The hot topics in this ifeld were the formation of fungal bioiflm, susceptibilities and mechanism of this virulence.%目的:分析全球医学真菌生物膜文献概貌,了解医学真菌生物膜研究现状,为进一步研究提供思路和依据。方法利用汤森路透的TDA软件分析PubMed数据库收录的医学真菌生物膜相关文献的时间、国家、期刊、作者和高频主

  18. Bibliometric assessment of publication output of child and adolescent psychiatric/psychological affiliations between 2005 and 2010 based on the databases PubMed and Scopus.

    Science.gov (United States)

    Albayrak, Ozgür; Föcker, Manuel; Wibker, Katrin; Hebebrand, Johannes

    2012-06-01

    We aimed to determine the quantitative scientific publication output of child and adolescent psychiatric/psychological affiliations during 2005-2010 by country based on both, "PubMed" and "Scopus" and performed a bibliometric qualitative evaluation for 2009 using "PubMed". We performed our search by affiliation related to child and adolescent psychiatric/psychological institutions using "PubMed". For the quantitative analysis for 2005-2010, we counted the number of abstracts. For the qualitative analysis for 2009 we derived the impact factor of each abstract's journal from "Journal Citation Reports". We related total impact factor scores to the gross domestic product (GDP) and population size of each country. Additionally, we used "Scopus" to determine the number of abstracts for each country that was identified via "PubMed" for 2009 and compared the ranking of countries between the two databases. 61 % of the publications between 2005 and 2010 originated from European countries and 26 % from the USA. After adjustment for GDP and population size, the ranking positions changed in favor of smaller European countries with a population size of less than 20 million inhabitants. The ranking of countries for the count of articles in 2009 as derived from "Scopus" was similar to that identified via the "PubMed" search. The performed search revealed only minor differences between "Scopus" and "PubMed" related to the ranking of countries. Our data indicate a sharp difference between countries with a high versus low GDP with regard to scientific publication output in child and adolescent psychiatry/psychology.

  19. 使用PubMed/Medline的网络个性化服务功能为药理学信息进行个性化服务%To Facilitate Personalize Information Service in Pharmacology by Means of the Personalized Service Functions of PubMed/Medline

    Institute of Scientific and Technical Information of China (English)

    陆一

    2008-01-01

    目的:使用PubMed/Medline的网络个性化服务功能为药理学信息进行个性化服务.方法:研究My NCBI对PubMed个性化服务的发展过程和各项功能.结果:利用PubMed/Medline的My NCBI、RSS、E-mail、SMS和PDA downloads功能,可对药理学信息按个人要求进行个性化服务.结论:PubMed/Medline的My NCBI、RSS、E-mail、SMS和PDA downloads功能是一种满足个人信息服务的好方法.

  20. MeSH Now: automatic MeSH indexing at PubMed scale via learning to rank.

    Science.gov (United States)

    Mao, Yuqing; Lu, Zhiyong

    2017-04-17

    MeSH indexing is the task of assigning relevant MeSH terms based on a manual reading of scholarly publications by human indexers. The task is highly important for improving literature retrieval and many other scientific investigations in biomedical research. Unfortunately, given its manual nature, the process of MeSH indexing is both time-consuming (new articles are not immediately indexed until 2 or 3 months later) and costly (approximately ten dollars per article). In response, automatic indexing by computers has been previously proposed and attempted but remains challenging. In order to advance the state of the art in automatic MeSH indexing, a community-wide shared task called BioASQ was recently organized. We propose MeSH Now, an integrated approach that first uses multiple strategies to generate a combined list of candidate MeSH terms for a target article. Through a novel learning-to-rank framework, MeSH Now then ranks the list of candidate terms based on their relevance to the target article. Finally, MeSH Now selects the highest-ranked MeSH terms via a post-processing module. We assessed MeSH Now on two separate benchmarking datasets using traditional precision, recall and F1-score metrics. In both evaluations, MeSH Now consistently achieved over 0.60 in F-score, ranging from 0.610 to 0.612. Furthermore, additional experiments show that MeSH Now can be optimized by parallel computing in order to process MEDLINE documents on a large scale. We conclude that MeSH Now is a robust approach with state-of-the-art performance for automatic MeSH indexing and that MeSH Now is capable of processing PubMed scale documents within a reasonable time frame. http://www.ncbi.nlm.nih.gov/CBBresearch/Lu/Demo/MeSHNow/ .

  1. CHRISTMAS 2015 : THE PUBLICATION GAME Use of positive and negative words in scientific PubMed abstracts between 1974 and 2014: retrospective analysis

    NARCIS (Netherlands)

    Vinkers, Christiaan H.; Tijdink, Joeri K.; Otte, Wim

    2015-01-01

    Objective To investigate whether language used in science abstracts can skew towards the use of strikingly positive and negative words over time. Design Retrospective analysis of all scientific abstracts in PubMed between 1974 and 2014. Methods The yearly frequencies of positive, negative, and neutr

  2. Preliminary comparison of the Essie and PubMed search engines for answering clinical questions using MD on Tap, a PDA-based program for accessing biomedical literature.

    Science.gov (United States)

    Sutton, Victoria R; Hauser, Susan E

    2005-01-01

    MD on Tap, a PDA application that searches and retrieves biomedical literature, is specifically designed for use by mobile healthcare professionals. With the goal of improving the usability of the application, a preliminary comparison was made of two search engines (PubMed and Essie) to determine which provided most efficient path to the desired clinically-relevant information.

  3. PubstractHelper: A Web-based Text-Mining Tool for Marking Sentences in Abstracts from PubMed Using Multiple User-Defined Keywords.

    Science.gov (United States)

    Chen, Chou-Cheng; Ho, Chung-Liang

    2014-01-01

    While a huge amount of information about biological literature can be obtained by searching the PubMed database, reading through all the titles and abstracts resulting from such a search for useful information is inefficient. Text mining makes it possible to increase this efficiency. Some websites use text mining to gather information from the PubMed database; however, they are database-oriented, using pre-defined search keywords while lacking a query interface for user-defined search inputs. We present the PubMed Abstract Reading Helper (PubstractHelper) website which combines text mining and reading assistance for an efficient PubMed search. PubstractHelper can accept a maximum of ten groups of keywords, within each group containing up to ten keywords. The principle behind the text-mining function of PubstractHelper is that keywords contained in the same sentence are likely to be related. PubstractHelper highlights sentences with co-occurring keywords in different colors. The user can download the PMID and the abstracts with color markings to be reviewed later. The PubstractHelper website can help users to identify relevant publications based on the presence of related keywords, which should be a handy tool for their research. http://bio.yungyun.com.tw/ATM/PubstractHelper.aspx and http://holab.med.ncku.edu.tw/ATM/PubstractHelper.aspx.

  4. 28 CFR 0.64-5 - Policy with regard to bringing charges under the Economic Espionage Act of 1996, Pub. L. 104-294...

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Policy with regard to bringing charges under the Economic Espionage Act of 1996, Pub. L. 104-294, effective October 11, 1996. 0.64-5 Section 0.64-5 Judicial Administration DEPARTMENT OF JUSTICE ORGANIZATION OF THE DEPARTMENT OF JUSTICE...

  5. 45 CFR 74.16 - Resource Conservation and Recovery Act (RCRA, Section 6002 of Pub. L. No. 94-580 (Codified at 42...

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Resource Conservation and Recovery Act (RCRA... COMMERCIAL ORGANIZATIONS Pre-Award Requirements § 74.16 Resource Conservation and Recovery Act (RCRA, Section 6002 of Pub. L. No. 94-580 (Codified at 42 U.S.C. 6962)). Under the Act, any State agency or agency...

  6. A random set scoring model for prioritization of disease candidate genes using protein complexes and data-mining of GeneRIF, OMIM and PubMed records

    DEFF Research Database (Denmark)

    Jiang, Li; Edwards, Stefan M.; Thomsen, Bo

    2014-01-01

    from PubMed abstracts, OMIM, and GeneRIF records. We also investigated the validity of several vocabulary filters and different likelihood thresholds for predicted protein-protein interactions in terms of their effect on the network-based gene-prioritization approach, which relies on text...

  7. Mobility Aids: MedlinePlus Health Topic

    Science.gov (United States)

    ... ClinicalTrials.gov: Self-Help Devices (National Institutes of Health) Journal Articles References and abstracts from MEDLINE/PubMed (National ... Eldercare at Home: Mobility Problems (AGS Foundation for Health in Aging) Topic Image MedlinePlus Email Updates Get Mobility Aids ...

  8. 78 FR 33115 - Notice of Permit Applications Received Under the Antarctic Conservation Act of 1978 (Pub. L. 95-541)

    Science.gov (United States)

    2013-06-03

    .... 95-541), as amended by the Antarctic Science, Tourism and Conservation Act of 1996, has developed...-reproductive history will receive a full health assessment (mass, morphometrics, blood and tissue samples) and...

  9. To compare PubMed Clinical Queries and UpToDate in teaching information mastery to clinical residents: a crossover randomized controlled trial.

    Directory of Open Access Journals (Sweden)

    Ladan Sayyah Ensan

    Full Text Available PURPOSE: To compare PubMed Clinical Queries and UpToDate regarding the amount and speed of information retrieval and users' satisfaction. METHOD: A cross-over randomized trial was conducted in February 2009 in Tehran University of Medical Sciences that included 44 year-one or two residents who participated in an information mastery workshop. A one-hour lecture on the principles of information mastery was organized followed by self learning slide shows before using each database. Subsequently, participants were randomly assigned to answer 2 clinical scenarios using either UpToDate or PubMed Clinical Queries then crossed to use the other database to answer 2 different clinical scenarios. The proportion of relevantly answered clinical scenarios, time to answer retrieval, and users' satisfaction were measured in each database. RESULTS: Based on intention-to-treat analysis, participants retrieved the answer of 67 (76% questions using UpToDate and 38 (43% questions using PubMed Clinical Queries (P<0.001. The median time to answer retrieval was 17 min (95% CI: 16 to 18 using UpToDate compared to 29 min (95% CI: 26 to 32 using PubMed Clinical Queries (P<0.001. The satisfaction with the accuracy of retrieved answers, interaction with UpToDate and also overall satisfaction were higher among UpToDate users compared to PubMed Clinical Queries users (P<0.001. CONCLUSIONS: For first time users, using UpToDate compared to Pubmed Clinical Queries can lead to not only a higher proportion of relevant answer retrieval within a shorter time, but also a higher users' satisfaction. So, addition of tutoring pre-appraised sources such as UpToDate to the information mastery curricula seems to be highly efficient.

  10. To compare PubMed Clinical Queries and UpToDate in teaching information mastery to clinical residents: a crossover randomized controlled trial.

    Science.gov (United States)

    Sayyah Ensan, Ladan; Faghankhani, Masoomeh; Javanbakht, Anna; Ahmadi, Seyed-Foad; Baradaran, Hamid Reza

    2011-01-01

    To compare PubMed Clinical Queries and UpToDate regarding the amount and speed of information retrieval and users' satisfaction. A cross-over randomized trial was conducted in February 2009 in Tehran University of Medical Sciences that included 44 year-one or two residents who participated in an information mastery workshop. A one-hour lecture on the principles of information mastery was organized followed by self learning slide shows before using each database. Subsequently, participants were randomly assigned to answer 2 clinical scenarios using either UpToDate or PubMed Clinical Queries then crossed to use the other database to answer 2 different clinical scenarios. The proportion of relevantly answered clinical scenarios, time to answer retrieval, and users' satisfaction were measured in each database. Based on intention-to-treat analysis, participants retrieved the answer of 67 (76%) questions using UpToDate and 38 (43%) questions using PubMed Clinical Queries (PUpToDate compared to 29 min (95% CI: 26 to 32) using PubMed Clinical Queries (PUpToDate and also overall satisfaction were higher among UpToDate users compared to PubMed Clinical Queries users (PUpToDate compared to Pubmed Clinical Queries can lead to not only a higher proportion of relevant answer retrieval within a shorter time, but also a higher users' satisfaction. So, addition of tutoring pre-appraised sources such as UpToDate to the information mastery curricula seems to be highly efficient.

  11. Mentoring programs for medical students--a review of the PubMed literature 2000-2008.

    Science.gov (United States)

    Frei, Esther; Stamm, Martina; Buddeberg-Fischer, Barbara

    2010-04-30

    Although mentoring is acknowledged as a key to successful and satisfying careers in medicine, formal mentoring programs for medical students are lacking in most countries. Within the framework of planning a mentoring program for medical students at Zurich University, an investigation was carried out into what types of programs exist, what the objectives pursued by such programs are, and what effects are reported. A PubMed literature search was conducted for 2000 - 2008 using the following keywords or their combinations: mentoring, mentoring program, medical student, mentor, mentee, protégé, mentorship. Although a total of 438 publications were identified, only 25 papers met the selection criteria for structured programs and student mentoring surveys. The mentoring programs reported in 14 papers aim to provide career counseling, develop professionalism, increase students' interest in research, and support them in their personal growth. There are both one-to-one and group mentorships, established in the first two years of medical school and continuing through graduation. The personal student-faculty relationship is important in that it helps students to feel that they are benefiting from individual advice and encourages them to give more thought to their career choices. Other benefits are an increase in research productivity and improved medical school performance in general. Mentored students also rate their overall well-being as higher. - The 11 surveys address the requirements for being an effective mentor as well as a successful mentee. A mentor should empower and encourage the mentee, be a role model, build a professional network, and assist in the mentee's personal development. A mentee should set agendas, follow through, accept criticism, and be able to assess performance and the benefits derived from the mentoring relationship. Mentoring is obviously an important career advancement tool for medical students. In Europe, more mentoring programs should be

  12. Bis(2,9-dimethyl-1,10-phenanthrolin-1-ium) 2,5-di-carb-oxy-benzene-1,4-di-carb-oxyl-ate-2,9-dimethyl-1,10-phenanthroline-benzene-1,2,4,5-tetra-carb-oxy-lic acid (1/2/1).

    Science.gov (United States)

    Arman, Hadi D; Kaulgud, Trupta; Tiekink, Edward R T

    2013-01-01

    The asymmetric unit of the title co-crystal, 2C14H13N2 (+)·C10H4O8 (2-)·2C14H12N2·C10H6O8, comprises a 2,9-dimethyl-1,10-phenanthrolin-1-ium cation (Me2PhenH(+)) and a 2,9-dimethyl-1,10-phenanthroline mol-ecule (Me2Phen), each in a general position, and half each of a 2,5-di-carb-oxy-benzene-1,4-di-carboxyl-ate dianion (LH2 (2-)) and a benzene-1,2,4,5-tetra-carb-oxy-lic acid mol-ecule (LH4), each being disposed about a centre of inversion. Small twists are evident in the dianion [the C-C-C-O torsion angles are 168.41 (18) and 16.2 (3)°], whereas a major twist is found for one carb-oxy-lic acid group in the neutral mol-ecule [C-C-C-O = 66.3 (2) and 18.2 (3)°]. The most prominent feature of the crystal packing is the formation of linear supra-molecular chains along [001] mediated by charge-assisted O-H⋯O(-) hydrogen bonding between alternating LH4 and LH2 (2-). These are connected to the Me2PhenH(+) and Me2Phen species by N-H⋯O and O-H⋯N hydrogen bonds, respectively. A three-dimensional architecture is formed by C-H⋯O and π-π inter-actions [inter-centroid distance = 3.5337 (17) Å].

  13. Crystal structures of 4-meth-oxy-benzoic acid-1,3-bis-(pyridin-4-yl)propane (2/1) and biphenyl-4,4'-di-carb-oxy-lic acid-4-meth-oxy-pyridine (1/2).

    Science.gov (United States)

    Gotoh, Kazuma; Ishida, Hiroyuki

    2017-07-01

    The crystal structures of two hydrogen-bonded compounds, namely 4-meth-oxy-benzoic acid-1,3-bis-(pyridin-4-yl)propane (2/1), C13H14.59N2·C8H7.67O3·C8H7.74O3, (I), and biphenyl-4,4'-di-carb-oxy-lic acid-4-meth-oxy-pyridine (1/2), C14H9.43O4·C6H7.32NO·C6H7.25NO, (II), have been determined at 93 K. In (I), the asymmetric unit consists of two crystallographically independent 4-meth-oxy-benzoic acid mol-ecules and one 1,3-bis-(pyridin-4-yl)propane mol-ecule. The asymmetric unit of (II) comprises one biphenyl-4,4'-di-carb-oxy-lic acid mol-ecule and two independent 4-meth-oxy-pyridine mol-ecules. In each crystal, the acid and base mol-ecules are linked by short O-H⋯N/N-H⋯O hydrogen bonds, in which H atoms are disordered over the acid O-atom and base N-atom sites, forming a linear hydrogen-bonded 2:1 or 1:2 unit of the acid and the base. The 2:1 units of (I) are linked via C-H⋯π, π-π and C-H⋯O inter-actions into a tape structure along [101], while the 1:2 units of (II) form a double-chain structure along [-101] through π-π and C-H⋯O inter-actions.

  14. Achieving a “Grand Convergence” in Global Health: Modeling the Technical Inputs, Costs, and Impacts from 2016 to 2030

    Science.gov (United States)

    Boyle, Colin F.; Levin, Carol; Hatefi, Arian; Madriz, Solange; Santos, Nicole

    2015-01-01

    Background The Commission on Investing in Health published its report, GlobalHealth2035, in 2013, estimating an investment case for a grand convergence in health outcomes globally. In support of the drafting of the Sustainable Development Goals (SDGs), we estimate what the grand convergence investment case might achieve—and what investment would be required—by 2030. Methods and Findings Our projection focuses on a sub-set of low-income (LIC) or lower-middle-income countries (LMIC). We start with a country-based (bottom-up) analysis of the costs and impact of scaling up reproductive, maternal, and child health tools, and select HIV and malaria interventions. We then incorporate global (top-down) analyses of the costs and impacts of scaling up existing tools for tuberculosis, additional HIV interventions, the costs to strengthen health systems, and the costs and benefits from scaling up new health interventions over the time horizon of this forecast. These data are then allocated to individual countries to provide an aggregate projection of potential cost and impact at the country level. Finally, incremental costs of R&D for low-income economies and the costs of addressing NTDs are added to provide a global total cost estimate of the investment scenario. Results Compared with a constant coverage scenario, there would be more than 60 million deaths averted in LIC and 70 million deaths averted in LMIC between 2016 and 2030. For the years 2015, 2020, 2025, and 2030, the incremental costs of convergence in LIC would be (US billion) $24.3, $21.8, $24.7, and $27, respectively; in LMIC, the incremental costs would be (US billion) $34.75, $38.9, $48.7, and $56.3, respectively. Conclusion Key health outcomes in low- and low-middle income countries can significantly converge with those of wealthier countries by 2030, and the notion of a “grand convergence” may serve as a unifying theme for health indicators in the SDGs. PMID:26452263

  15. 75 FR 70009 - Development of Health Risk Assessment Guidance

    Science.gov (United States)

    2010-11-16

    ... HUMAN SERVICES Centers for Disease Control and Prevention Development of Health Risk Assessment Guidance... guidance concerning Health Risk Assessment (HRAs). Section 4103 of the Affordable Care Act (ACA) (Pub. L. 111-148) requires that a health risk assessment be included in the annual wellness visit benefit...

  16. Mystery in genetics: PUB4 gives a clue to the complex mechanism of CLV signaling pathway in the shoot apical meristem.

    Science.gov (United States)

    Kinoshita, Atsuko; Seo, Mitsunori; Kamiya, Yuji; Sawa, Shinichiro

    2015-01-01

    Postembryonic growth and development in higher plants are ultimately reliant on the activity of meristems, where the cells divide frequently to provide source cells for new organs and tissues while in part maintain their pluripotent nature as stem cells. The shoot apical meristem (SAM) is maintained throughout the life of plants and responsible for the development of all areal tissues. In Arabidopsis thaliana, the size of SAM is controlled by a peptide ligand, CLAVATA3 (CLV3). Previously, genetic studies have identified several genes that function downstream of CLV3, many of which, intriguingly, encode receptors. Recently we identified an E3 ubiquitin ligase, PLANT U-BOX 4 (PUB4), as a key regulatory component of root meristem maintenance that functions downstream of an exogenous synthetic CLV3 peptide. Here, we report an additional function of PUB4 in the SAM.

  17. Comparative Study on Pubmed, Web of Science, Scopus and Google Scholar%Pub Med,Web of Science,Scopus以及Google Scholar比较研究

    Institute of Scientific and Technical Information of China (English)

    廖一平

    2009-01-01

    介绍PubMed、Web of Science和Scopus 3个数据库以及Google Scholar的概况,并通过具体实例对其在文献信息检索和引文分析等方面进行评价,指出优缺点,为广大用户提供参考依据.

  18. BTB-BACK Domain Protein POB1 Suppresses Immune Cell Death by Targeting Ubiquitin E3 ligase PUB17 for Degradation

    Science.gov (United States)

    Mesmar, Joelle; McLellan, Hazel; Yang, Chengwei; Craig, Adam; Zhang, Cunjin; Moore, Jonathan David; Tian, Zhendong; Birch, Paul R. J.; Sadanandom, Ari

    2017-01-01

    Hypersensitive response programmed cell death (HR-PCD) is a critical feature in plant immunity required for pathogen restriction and prevention of disease development. The precise control of this process is paramount to cell survival and an effective immune response. The discovery of new components that function to suppress HR-PCD will be instrumental in understanding the regulation of this fundamental mechanism. Here we report the identification and characterisation of a BTB domain E3 ligase protein, POB1, that functions to suppress HR-PCD triggered by evolutionarily diverse pathogens. Nicotiana benthamiana and tobacco plants with reduced POB1 activity show accelerated HR-PCD whilst those with increased POB1 levels show attenuated HR-PCD. We demonstrate that POB1 dimerization and nuclear localization are vital for its function in HR-PCD suppression. Using protein-protein interaction assays, we identify the Plant U-Box E3 ligase PUB17, a well established positive regulator of plant innate immunity, as a target for POB1-mediated proteasomal degradation. Using confocal imaging and in planta immunoprecipitation assays we show that POB1 interacts with PUB17 in the nucleus and stimulates its degradation. Mutated versions of POB1 that show reduced interaction with PUB17 fail to suppress HR-PCD, indicating that POB1-mediated degradation of PUB17 U-box E3 ligase is an important step for negative regulation of specific immune pathways in plants. Our data reveals a new mechanism for BTB domain proteins in suppressing HR-PCD in plant innate immune responses. PMID:28056034

  19. PubMed收录坐骨神经病变相关文献的计量学分析方法分析

    Institute of Scientific and Technical Information of China (English)

    金社辉

    2014-01-01

    PubMed收录的坐骨神经病变相关文献的年份、国别、期刊来源、多产作者、主要主题词进行统计,并对有关数据进行分析,以明确坐骨神经病变相关文献分布特点和研究现状。

  20. Utilization of bar and izakaya-pub establishments among middle-aged and elderly Japanese men to mitigate stress

    OpenAIRE

    Ohnishi Mayumi; Nakao Rieko; Kawasaki Ryokko; Nitta Akiko; Hamada Yukari; Nakane Hideyuki

    2012-01-01

    Abstract Japanese suicide rate is one of the highest among industrialized nations, especially following the economic crisis of the 1990s, with more than 30000 suicides every year since 1998. Previous studies have pointed out to relationships between overwork and/or job stress, and death and other health risks, and suggested several possible avenues for releasing stress and emotional burden, including suicidal ideation, through talking with intimate friends, family, and specialists, such as co...

  1. Reviewing the application of the balanced scorecard with implications for low-income health settings.

    Science.gov (United States)

    Rabbani, Fauziah; Jafri, S M Wasin; Abbas, Farhat; Pappas, Gregory; Brommels, Mats; Tomson, Goran

    2007-01-01

    High-income countries (HICs) are increasingly making use of the balanced scorecard (BSC) in healthcare. Evidence about BSC usage in low-income countries (LICs) is deficient. This study assessed feasibility of BSC use in LICs. Systematic review of electronic databases shows that the BSC improved patient, staff, clinical, and financial outcomes in HICs. To translate the experience of BSC use in HICs to their use in LICs, the applicability parameters of the National Committee for Quality Assurance were applied. Despite contextual challenges, pilot testing of BSC use can be undertaken in selected LICs. Committed leadership, cultural readiness, quality information systems, viable strategic plans, and optimum resources are required.

  2. Perceived barriers and facilitators to mental health help-seeking in young people: a systematic review

    National Research Council Canada - National Science Library

    Gulliver, Amelia; Griffiths, Kathleen M; Christensen, Helen

    2010-01-01

    ... to help-seeking for common mental health problems. Twenty two published studies of perceived barriers or facilitators in adolescents or young adults were identified through searches of PubMed, PsycInfo, and the Cochrane database...

  3. A random set scoring model for prioritization of disease candidate genes using protein complexes and data-mining of GeneRIF, OMIM and PubMed records

    DEFF Research Database (Denmark)

    Jiang, Li; Edwards, Stefan M.; Thomsen, Bo

    2014-01-01

    from PubMed abstracts, OMIM, and GeneRIF records. We also investigated the validity of several vocabulary filters and different likelihood thresholds for predicted protein-protein interactions in terms of their effect on the network-based gene-prioritization approach, which relies on text-mining......Background: Prioritizing genetic variants is a challenge because disease susceptibility loci are often located in genes of unknown function or the relationship with the corresponding phenotype is unclear. A global data-mining exercise on the biomedical literature can establish the phenotypic...

  4. Toddler Nutrition: MedlinePlus Health Topic

    Science.gov (United States)

    ... ClinicalTrials.gov: Toddler Nutrition (National Institutes of Health) Journal Articles References and abstracts from MEDLINE/PubMed (National Library of Medicine) Article: Impact of Prolonged Breastfeeding on Dental Caries: A Population-Based Birth... ... Also in Spanish School Meals Contacts by State (Food and Nutrition Service) ...

  5. Distributed chemical computing using ChemStar: an open source java remote method invocation architecture applied to large scale molecular data from PubChem.

    Science.gov (United States)

    Karthikeyan, M; Krishnan, S; Pandey, Anil Kumar; Bender, Andreas; Tropsha, Alexander

    2008-04-01

    We present the application of a Java remote method invocation (RMI) based open source architecture to distributed chemical computing. This architecture was previously employed for distributed data harvesting of chemical information from the Internet via the Google application programming interface (API; ChemXtreme). Due to its open source character and its flexibility, the underlying server/client framework can be quickly adopted to virtually every computational task that can be parallelized. Here, we present the server/client communication framework as well as an application to distributed computing of chemical properties on a large scale (currently the size of PubChem; about 18 million compounds), using both the Marvin toolkit as well as the open source JOELib package. As an application, for this set of compounds, the agreement of log P and TPSA between the packages was compared. Outliers were found to be mostly non-druglike compounds and differences could usually be explained by differences in the underlying algorithms. ChemStar is the first open source distributed chemical computing environment built on Java RMI, which is also easily adaptable to user demands due to its "plug-in architecture". The complete source codes as well as calculated properties along with links to PubChem resources are available on the Internet via a graphical user interface at http://moltable.ncl.res.in/chemstar/.

  6. The Search Engine of Biochemistry Journals%Medline(PubMed)生物化学杂志文献搜索引擎开发研究

    Institute of Scientific and Technical Information of China (English)

    张玉萍; 罗佳滨; 张丽岩; 吕学诜; 张淑红

    2004-01-01

    为了方便生物化学工作者快捷、准确地查阅生物化学杂志文献,开发和利用NCBI的Medline数据库的生物化学杂志文献资源.从Medline (PubMed)中检索并列出175种有关生物化学的杂志名录,制作了每种杂志及部分杂志年份相应的超级链接,组成一个有关生物化学杂志文献的搜索引擎.此搜索引擎能快捷、准确、动态地检索175种生物化学杂志全部文献题录及部分杂志各年的文献题录,并可在PubMed中进一步检索出文献的摘要和部分全文.

  7. All Information Is Not Equal: Using the Literature Databases PubMed and The Cochrane Library for Identifying the Evidence on Granulocyte Transfusion Therapy.

    Science.gov (United States)

    Metzendorf, Maria-Inti; Schulz, Manuela; Braun, Volker

    2014-10-01

    To be able to take well-informed decisions or carry out sound research, clinicians and researchers alike require specific information seeking skills matching their respective information needs. Biomedical information is traditionally available via different literature databases. This article gives an introduction to two diverging sources, PubMed (23 million references) and The Cochrane Library (800,000 references), both of which offer sophisticated instruments for searching an increasing amount of medical publications of varied quality and ambition. Whereas PubMed as an unfiltered source of primary literature comprises all different kinds of publication types occurring in academic journals, The Cochrane Library is a pre-filtered source which offers access to either synthesized publication types or critically appraised and carefully selected references. A search approach has to be carried out deliberately and requires a good knowledge on the scope and features of the databases as well as on the ability to build a search strategy in a structured way. We present a specific and a sensitive search approach, making use of both databases within two application case scenarios in order to identify the evidence on granulocyte transfusions for infections in adult patients with neutropenia.

  8. Journalling and Public Health Education: Thinking about Reflecting...

    Science.gov (United States)

    Sendall, Marguerite C.; Domocol, Michelle L.

    2013-01-01

    Purpose: The purpose of this research is to understand reflective journalling in a first year Public Health practice unit. Design/methodology/approach: This research uses pure phenomenography to interpret students' descriptions of reflective journalling. Data were collected from 32 students enrolled in PUB215 Public Health Practice in the School…

  9. Harms of Smoking and Health Benefits of Quitting

    Science.gov (United States)

    ... Amitai Y. Water-pipe (narghile) smoking: An emerging health risk behavior. Pediatrics 2005; 116(1):e113‒119. [PubMed Abstract] Cobb C, Ward KD, Maziak W, Shihadeh AL, Eissenberg T. Waterpipe tobacco smoking: An emerging health crisis in the ...

  10. Why Principal Investigators Funded by the U.S. National Institutes of Health Publish in the Public Library of Science Journals

    Science.gov (United States)

    Pontika, Nancy

    2015-01-01

    Introduction: The National Institutes of Health public access policy requires the principal investigators of any Institutes-funded research to submit their manuscript to PubMed Central, and the open access publisher Public Library of Science submits all articles to PubMed Central, irrespective of funder. Whether the investigators, who made the…

  11. 78 FR 72255 - Medicare and Medicaid Programs; Home Health Prospective Payment System Rate Update for CY 2014...

    Science.gov (United States)

    2013-12-02

    ... Affordable Care Act of 2010 (Pub. L 111-148), as amended by the Health Care and Education Reconciliation Act... 401.0 Malignant essential 1 hypertension. 414.12 Dissection of coronary 1 artery. 447.2 Rupture...

  12. Health literacy and women's health: challenges and opportunities.

    Science.gov (United States)

    Corrarino, Jane E

    2013-01-01

    This article describes the impact of health literacy on women's health and provides strategies for addressing this public health issue. A comprehensive literature review was conducted of peer-reviewed journals. Multiple electronic databases were used, including CINAHL, MEDLINE, PubMed, and Google Scholar. Key words were used to identify articles and were combined to include health literacy, health behavior, women's health, patient education, and professional role. Additional articles were identified as a result of reviewing reference lists found during the electronic search. Health literacy is a complex issue that affects many women and can adversely affect women's knowledge, ability to adhere to clinical plans of care, and health outcomes for women and their children. It is estimated that 36% of adults in the United States possess limited health literacy skills. Effective strategies can be used by health care providers to address this serious problem, including clear and effective communication, development of health education materials, professional education, and development of community partnerships. Health literacy is a serious problem. Effective approaches can be employed to blunt the adverse effect on women's health. Health care providers are well positioned to demonstrate leadership within the health care system regarding health literacy. © 2013 by the American College of Nurse-Midwives.

  13. Mental health problems in health professionals

    Directory of Open Access Journals (Sweden)

    Koinis Ar.

    2014-03-01

    Full Text Available Introduction: For the vast majority of nurses and doctors, the choice of their profession, represents a successful career, even though this isn’t a fact for everyone. For some of them reflects a journey into despair. A significant number of doctors and nurses, suffers from serious mental illness.Materials and Methods: It is conducted literature review of published journals from scientific databases such as Medline, Pub Med, Scholar Google, for the period 1985-2010, using keywords and combination of them: "health professionals", "psychiatric morbidity", "effects of stress on mental health "," mental disorders " Literature Review: There are researches in population health professionals, more often to doctors and nurses / only three, referred to mental illnesses mainly burnout, depression, anxiety disorders, alcoholism, and suicide and the effect thereof on the quality of life. Total of 215 studies were found and 48 of the were reviewed for this study.Conclusions: It is obvious from the literature, that mental health problems of the health professionals are not treated promptly or with the appropriate efficiency. The reasons associated with the stigma of mental illness by illness, the subsequent denial, the misconceived professional solidarity, culture of " medical omnipotence " for physicians. Τhe timeless trend of occupational health and diagnoses to self treated their health problems , even if the knowledge on specific issues are almost non-existent.

  14. GMJ 2009 page 1.pub into PDF.pub

    African Journals Online (AJOL)

    McBee

    study revealed that accumulation of heavy metals particularly iron and lead ... Hence, development of a mine in such areas requires a comprehensive environmental impact assessment to ascertain the environmental quality of the adjoining ...

  15. GMJ 2009 page 1.pub into PDF.pub

    African Journals Online (AJOL)

    McBee

    Do Students of Mining and Allied Engineering Programmes have any Problems in English ... could be used to assess their competence level in English. The comments .... exercise at the end of the second semester of the 2005/2006 academic.

  16. GMJ 2009 page 1.pub into PDF.pub

    African Journals Online (AJOL)

    McBee

    Analysis of Truck Downtimes Using Log Dispersion Plot*. V. A. Temeng and P. A. Eshun ... 55% (Knights, 1999) of total mining operating cost constitutes a key ..... Mine Finance, Economic Evaluation and Risk Analysis. He is currently a Senior ...

  17. Health and fertility in World Health Organization group 2 anovulatory women

    NARCIS (Netherlands)

    Baird, D. T.; Balen, A.; Escobar-Morreale, H. F.; Evers, J. L. H.; Fauser, B. C. J. M.; Franks, S.; Glasier, A.; Homburg, R.; La Vecchia, C.; Crosignani, P. G.; Devroey, P.; Diedrich, K.; Fraser, L.; Gianaroli, L.; Liebaers, I.; Sunde, A.; Tapanainen, J. S.; Tarlatzis, B.; Van Steirteghem, A.; Veiga, A.; Evers, J. L. H.

    2012-01-01

    Disruption of ovulation occurs in different types of clinical infertility. The World Health Organization (WHO) has provided a classification of ovulation disorders. This review focuses on WHO group 2 anovulation. Searches were performed in Medline/PubMed and EMBASE. Each subject summary was presente

  18. Cyberbullying and adolescent mental health: systematic review

    OpenAIRE

    Sara Mota Borges Bottino; Cássio M. C. Bottino; Caroline Gomez Regina; Aline Villa Lobo Correia; Wagner Silva Ribeiro

    2015-01-01

    Cyberbullying is a new form of violence that is expressed through electronic media and has given rise to concern for parents, educators and researchers. In this paper, an association between cyberbullying and adolescent mental health will be assessed through a systematic review of two databases: PubMed and Virtual Health Library (BVS). The prevalence of cyberbullying ranged from 6.5% to 35.4%. Previous or current experiences of traditional bullying were associated with victims and perpetrator...

  19. Developing and validating predictive decision tree models from mining chemical structural fingerprints and high–throughput screening data in PubChem

    Directory of Open Access Journals (Sweden)

    Bryant Stephen H

    2008-09-01

    Full Text Available Abstract Background Recent advances in high-throughput screening (HTS techniques and readily available compound libraries generated using combinatorial chemistry or derived from natural products enable the testing of millions of compounds in a matter of days. Due to the amount of information produced by HTS assays, it is a very challenging task to mine the HTS data for potential interest in drug development research. Computational approaches for the analysis of HTS results face great challenges due to the large quantity of information and significant amounts of erroneous data produced. Results In this study, Decision Trees (DT based models were developed to discriminate compound bioactivities by using their chemical structure fingerprints provided in the PubChem system http://pubchem.ncbi.nlm.nih.gov. The DT models were examined for filtering biological activity data contained in four assays deposited in the PubChem Bioassay Database including assays tested for 5HT1a agonists, antagonists, and HIV-1 RT-RNase H inhibitors. The 10-fold Cross Validation (CV sensitivity, specificity and Matthews Correlation Coefficient (MCC for the models are 57.2~80.5%, 97.3~99.0%, 0.4~0.5 respectively. A further evaluation was also performed for DT models built for two independent bioassays, where inhibitors for the same HIV RNase target were screened using different compound libraries, this experiment yields enrichment factor of 4.4 and 9.7. Conclusion Our results suggest that the designed DT models can be used as a virtual screening technique as well as a complement to traditional approaches for hits selection.

  20. Using Clinical Data, Hypothesis Generation Tools and PubMed Trends to Discover the Association between Diabetic Retinopathy and Antihypertensive Drugs

    Energy Technology Data Exchange (ETDEWEB)

    Senter, Katherine G [ORNL; Sukumar, Sreenivas R [ORNL; Patton, Robert M [ORNL; Chaum, Ed [University of Tennessee, Knoxville (UTK)

    2015-01-01

    Diabetic retinopathy (DR) is a leading cause of blindness and common complication of diabetes. Many diabetic patients take antihypertensive drugs to prevent cardiovascular problems, but these drugs may have unintended consequences on eyesight. Six common classes of antihypertensive drug are angiotensin converting enzyme (ACE) inhibitors, alpha blockers, angiotensin receptor blockers (ARBs), -blockers, calcium channel blockers, and diuretics. Analysis of medical history data might indicate which of these drugs provide safe blood pressure control, and a literature review is often used to guide such analyses. Beyond manual reading of relevant publications, we sought to identify quantitative trends in literature from the biomedical database PubMed to compare with quantitative trends in the clinical data. By recording and analyzing PubMed search results, we found wide variation in the prevalence of each antihypertensive drug in DR literature. Drug classes developed more recently such as ACE inhibitors and ARBs were most prevalent. We also identified instances of change-over-time in publication patterns. We then compared these literature trends to a dataset of 500 diabetic patients from the UT Hamilton Eye Institute. Data for each patient included class of antihypertensive drug, presence and severity of DR. Graphical comparison revealed that older drug classes such as diuretics, calcium channel blockers, and -blockers were much more prevalent in the clinical data than in the DR and antihypertensive literature. Finally, quantitative analysis of the dataset revealed that patients taking -blockers were statistically more likely to have DR than patients taking other medications, controlling for presence of hypertension and year of diabetes onset. This finding was concerning given the prevalence of -blockers in the clinical data. We determined that clinical use of -blockers should be minimized in diabetic patients to prevent retinal damage.

  1. 75 FR 6673 - Expert Meeting on Measurement Criteria for Children's Health Insurance Program; Reauthorization...

    Science.gov (United States)

    2010-02-10

    ... Children's Health Insurance Program; Reauthorization Act Pediatric Quality Measures AGENCY: Agency for... (PQMP) under Section 1139A(b) of the Social Security Act as enacted in the Children's Health Insurance... INFORMATION: I. Purpose In early 2009, CHIPRA (Pub. L. 111-3) reauthorized the Child Health Insurance Program...

  2. 76 FR 52329 - Advisory Board on Radiation and Worker Health: Notice of Charter Renewal

    Science.gov (United States)

    2011-08-22

    ... HUMAN SERVICES Centers for Disease Control and Prevention Advisory Board on Radiation and Worker Health: Notice of Charter Renewal This gives notice under the Federal Advisory Committee Act (Pub. L. 92-463) of October 6, 1972, that the Advisory Board on Radiation and Worker Health, Department of Health and...

  3. 77 FR 38840 - Submission for OMB Review; Comment Request: Child Health Disparities Substudy for the National...

    Science.gov (United States)

    2012-06-29

    .... Need and Use of Information Collection: The Children's Health Act of 2000 (Pub. L. 106-310) states: (a... environment, genetics on child health and development. The Study defines ``environment'' broadly, taking a..., and quality) contribute to health disparities. Additionally, aspects of the social environment such as...

  4. keauhou_hi_pub.grd

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NGDC builds and distributes high-resolution, coastal digital elevation models (DEMs) that integrate ocean bathymetry and land topography to support NOAA's mission to...

  5. Adengala and Voegborlo.pub

    African Journals Online (AJOL)

    User

    Knowledge of the mobility and bioavailability of heavy metals in soils is necessary for the design of remediation ... (51.55%). Keywords: chemical fractionation, roadside soil, lead, copper, zinc, cadmium ... Numerous sequential extraction schemes (SES) have been .... lar Zn results were reported for soils from tail- ing dumps ...

  6. Nkyi and others.pub

    African Journals Online (AJOL)

    User

    The effects of collar diameter and lifting period on shoot biomass production of Teak (Tectona grandis Linn. F) stumps ... labour at the peak of planting of agricultural crops particularly ..... height and hormone application, Technical. Publication ...

  7. Health Applications for Corporate Health Management.

    Science.gov (United States)

    Steigner, Guido; Doarn, Charles R; Schütte, Michael; Matusiewicz, David; Thielscher, Christian

    2017-05-01

    Many corporate organizations around the world are looking at new ways to improve the health and well-being of their employees. Many have begun to use m-health approaches and unique applications (apps) to provide assistance. In Germany, both m-health and occupational health management (OHM) are growing quickly. Therefore, we hypothesized that the combination-apps usage in OHM-is growing as well. We studied the usage of health apps in large corporations for health management of employed individuals. To understand the environment in Germany, a two-part study was conducted. First, an extensive literature search was done and second, interviews were conducted with 12 of the 20 biggest companies' health management representatives. Using key search terms, 5,445 peer-reviewed journal articles traced with German databases and on PubMed were reviewed. Interestingly and somewhat surprising to the authors, none of them covered our specific topic. Interviews were conducted with 60% of the companies indicated. Only 3 out of 12 companies use apps. Four companies are piloting apps. With one exception, apps cover well-known areas such as food coaching, physical motion, smoking cessation, stress prevention, and other health-related subjects. One app used sensors in work clothing to prevent unhealthy motion. With a few exceptions, there has been no evaluation of the utility and utilization of apps. Current app usage in corporate health management in Germany is surprisingly low. Apps need to be better evaluated. Main obstacles-which could be resolved in the future-are legal restrictions (especially on data security), the lack of company-owned smart phones, misfit of apps and corporate health strategy, a lack of app evaluation, and high app prices.

  8. [Embase is a central resource for literature search in health science].

    Science.gov (United States)

    Eriksen, Mette Brandt; Christensen, Janne Buck; Frandsen, Tove Faber

    2016-06-06

    PubMed is often first choice for searching health sciences literature. However, even though Embase tends to be overlooked it is an important supplement to PubMed. The present paper provides an overview of the literature dealing with the significance of using Embase for systematic reviews and metaanalyses. Furthermore, the differences in the coverage of the two databases are described and the search process in Embase is presented using examples.

  9. PubMed数据库中(1979~2008)心理疗法文献计量学分析

    Institute of Scientific and Technical Information of China (English)

    孙涵雪; 刘旭峰; 许昌泰

    2010-01-01

    目的:对psychotherapy(心理疗法),behavior therapy(行为疗法),psychoanalytic therapy(精神分析疗法),cognitive therapy(认知疗法)和Morita therapy(森田疗法),以及psychology(心理学)文献进行计量分析,以确定其文献增长规律和发展趋势.方法:登录www.ncbi.nlm.nih.gov/Pubmed(PubMed数据库)后用"psychotherapy(心理疗法),behavior therapy(行为疗法),psychoanalytic therapy(精神分析疗法), cognitive therapy(认知疗法)和Morita therapy(森田疗法)"检索"从1979/01/01到 2008/12/31"文献量,同时检索数据库中文献的语言分布,并在此基础上分别检索各时间段,根据科学文献增长规律的理论,对数据进行分析.结果:1979至2008年底,PubMed数据库收录心理学文献689 144篇,心理疗法文献92 086篇,行为疗法78 407篇,精神分析疗法9 777篇,认知疗法33 775篇和森田疗法3547篇.这些心理疗法逐年累积文献量均呈递增趋势,其方程近似直线(Y=a+bX).1947~2008年的心理疗法文献仍以英语为主导(89.50%),其后是German(2.88%),French(2.21%),Russian(0.91%),Japanese(0.89%),Spanish(0.67%),Italian(0.33%),Chinese(0.18%),其他语种(2.42%).PubMed中检索结果,其中与心理学及相关学科568种,而研究心理疗法文献(1979-2008)主要刊载于心理学、神经心理学等相关杂志.用SPSS 15.0对收录心理疗法(1979-2008)逐年累积文献量进行回归分析,心理疗法文献呈缓慢递增.结论:心理疗法研究的文献量均呈上升趋势,表明心理疗法的研究仍是一个热点.影响心理学文献增长的主要因素是学科自身固有的规律和所处的环境条件.

  10. Electrochemical performances and preparation of nano-SiO2/LiC1O4/PVDF-HFP composite gel polymer electrolyte%纳米SiO2/LiClO4/PVDF-HFP复合凝胶聚合物电解质的制备及其电化学性能

    Institute of Scientific and Technical Information of China (English)

    韩坤明; 鲁道荣

    2008-01-01

    为了解决液态电解质锂离子电池存在的安全性问题,以偏氟乙烯和六氟丙烯的共聚物(PVDF-HFP)为基体,通过加入高氯酸锂(LiC1O4)、增塑剂(碳酸丙烯酯和碳酸二甲酯)、纳米二氧化硅等,制备出了具有高电导率的复合凝胶聚合物电解质.用X射线衍射仪测试聚合物电解质的结构,用交流阻抗法测定其电导率,用线性伏安扫描法研究了该聚合物电解质体系的电化学稳定性,并以其为电解质制备成锂离子电池进行充放电测试.结果表明,在20℃时复合凝胶聚合物电解质的电导率最高可达7.56×10-3S/cm,该电解质在4.6 V以下电化学窗口稳定,以其为电解质的锂离子电池具有良好的电化学性能,说明纳米SiO2/LiC1O4/PVDF-HFP复合凝胶聚合物电解质能满足锂离子电池的应用.

  11. An efficient algorithm coupled with synthetic minority over-sampling technique to classify imbalanced PubChem BioAssay data.

    Science.gov (United States)

    Hao, Ming; Wang, Yanli; Bryant, Stephen H

    2014-01-02

    It is common that imbalanced datasets are often generated from high-throughput screening (HTS). For a given dataset without taking into account the imbalanced nature, most classification methods tend to produce high predictive accuracy for the majority class, but significantly poor performance for the minority class. In this work, an efficient algorithm, GLMBoost, coupled with Synthetic Minority Over-sampling TEchnique (SMOTE) is developed and utilized to overcome the problem for several imbalanced datasets from PubChem BioAssay. By applying the proposed combinatorial method, those data of rare samples (active compounds), for which usually poor results are generated, can be detected apparently with high balanced accuracy (Gmean). As a comparison with GLMBoost, Random Forest (RF) combined with SMOTE is also adopted to classify the same datasets. Our results show that the former (GLMBoost+SMOTE) not only exhibits higher performance as measured by the percentage of correct classification for the rare samples (Sensitivity) and Gmean, but also demonstrates greater computational efficiency than the latter (RF+SMOTE). Therefore, we hope that the proposed combinatorial algorithm based on GLMBoost and SMOTE could be extensively used to tackle the imbalanced classification problem. Published by Elsevier B.V.

  12. An open source infrastructure for managing knowledge and finding potential collaborators in a domain-specific subset of PubMed, with an example from human genome epidemiology

    Directory of Open Access Journals (Sweden)

    Khoury Muin J

    2007-11-01

    Full Text Available Abstract Background Identifying relevant research in an ever-growing body of published literature is becoming increasingly difficult. Establishing domain-specific knowledge bases may be a more effective and efficient way to manage and query information within specific biomedical fields. Adopting controlled vocabulary is a critical step toward data integration and interoperability in any information system. We present an open source infrastructure that provides a powerful capacity for managing and mining data within a domain-specific knowledge base. As a practical application of our infrastructure, we presented two applications – Literature Finder and Investigator Browser – as well as a tool set for automating the data curating process for the human genome published literature database. The design of this infrastructure makes the system potentially extensible to other data sources. Results Information retrieval and usability tests demonstrated that the system had high rates of recall and precision, 90% and 93% respectively. The system was easy to learn, easy to use, reasonably speedy and effective. Conclusion The open source system infrastructure presented in this paper provides a novel approach to managing and querying information and knowledge from domain-specific PubMed data. Using the controlled vocabulary UMLS enhanced data integration and interoperability and the extensibility of the system. In addition, by using MVC-based design and Java as a platform-independent programming language, this system provides a potential infrastructure for any domain-specific knowledge base in the biomedical field.

  13. Fission yeast arrestin-related trafficking adaptor, Arn1/Any1, is ubiquitinated by Pub1 E3 ligase and regulates endocytosis of Cat1 amino acid transporter

    Directory of Open Access Journals (Sweden)

    Akio Nakashima

    2014-05-01

    Full Text Available The Tsc1–Tsc2 complex homologous to human tuberous sclerosis complex proteins governs amino acid uptake by regulating the expression and intracellular distribution of amino acid transporters in Schizosaccharomyces pombe. Here, we performed a genetic screening for molecules that are involved in amino acid uptake and found Arn1 (also known as Any1. Arn1 is homologous to ART1, an arrestin-related trafficking adaptor (ART in Saccharomyces cerevisiae, and contains a conserved arrestin motif, a ubiquitination site, and two PY motifs. Overexpression of arn1+ confers canavanine resistance on cells, whereas its disruption causes hypersensitivity to canavanine. We also show that Arn1 regulates endocytosis of the Cat1 amino acid transporter. Furthermore, deletion of arn1+ suppresses a defect of amino acid uptake and the aberrant Cat1 localization in tsc2Δ. Arn1 interacts with and is ubiquitinated by the Pub1 ubiquitin ligase, which is necessary to regulate Cat1 endocytosis. Cat1 undergoes ubiquitinations on lysine residues within the N-terminus, which are mediated, in part, by Arn1 to determine Cat1 localization. Correctively, Arn1 is an ART in S. pombe and contributes to amino acid uptake through regulating Cat1 endocytosis in which Tsc2 is involved.

  14. Investing in health: the economic case Report of the WISH Investing in Health Forum 2016

    Directory of Open Access Journals (Sweden)

    Gavin Yamey

    2017-05-01

    Full Text Available Developing country governments and aid agencies face dif­ficult decisions on how best to allocate their finite resources. Investments in many different sectors –including education, water and sanitation, transportation, and health– can all reap social and economic benefits. This report focuses specifically on the health sector. It presents compelling evidence of the value of scaling-up health investments. The economic case for increasing these investments in health has never been stronger. Having made progress in reducing maternal and child mortality, and deaths from infectious diseases, it is essential that policymakers do not become complacent. These gains will be quickly reversed without sustained health investments. Scaled-up investments will be needed to tackle the emerging non-communicable disease (NCD burden and to achieve universal health coverage (UHC. The value of investment in health far beyond its performance is reflected in economic prosperity through gross domestic product (GDP. People put a high monetary value on the additional years of life that health investments can bring –an inherent value to being alive for longer, unrelated to productivity. Policymakers need to do more to ensure that spending on health reflects people’s priorities. To make sure services are accessible to all, govern­ments have a clear role to play in financing health. Without public financing, there will be some who cannot afford the care they need, and they will be forced to choose sickness –perhaps even death– and financial ruin; a devastating choice that already pushes 150 million people into poverty every year.  In low-income countries (LICs and middle-income countries (MICs, public financing should be used to achieve universal coverage with a package of highly cost-effective interventions (‘best buys’. Governments failing to protect the health and wealth of their people in this way will be unable to reap the benefits of long

  15. Oral health in the agenda of priorities in public health

    Science.gov (United States)

    Antunes, José Leopoldo Ferreira; Toporcov, Tatiana Natasha; Bastos, João Luiz; Frazão, Paulo; Narvai, Paulo Capel; Peres, Marco Aurélio

    2016-01-01

    ABSTRACT This study describes the scientific production on oral health diffused in Revista de Saúde Pública, in the 50 years of its publication. A narrative review study was carried out using PubMed, as it is the search database that indexes all issues of the journal. From 1967 to 2015, 162 manuscripts specifically focused on oral health themes were published. This theme was present in all volumes of the journal, with increasing participation over the years. Dental caries was the most studied theme, constantly present in the journal since its first issue. Periodontal disease, fluorosis, malocclusions, and other themes emerged even before the decline of dental caries indicators. Oral health policy is the most recurring theme in the last two decades. Revista de Saúde Pública has been an important vehicle for dissemination, communication, and reflection on oral health, contributing in a relevant way to the technical-scientific interaction between professionals in this field. PMID:27598787

  16. Oral health in the agenda of priorities in public health

    Directory of Open Access Journals (Sweden)

    José Leopoldo Ferreira Antunes

    2016-01-01

    Full Text Available ABSTRACT This study describes the scientific production on oral health diffused in Revista de Saúde Pública, in the 50 years of its publication. A narrative review study was carried out using PubMed, as it is the search database that indexes all issues of the journal. From 1967 to 2015, 162 manuscripts specifically focused on oral health themes were published. This theme was present in all volumes of the journal, with increasing participation over the years. Dental caries was the most studied theme, constantly present in the journal since its first issue. Periodontal disease, fluorosis, malocclusions, and other themes emerged even before the decline of dental caries indicators. Oral health policy is the most recurring theme in the last two decades. Revista de Saúde Pública has been an important vehicle for dissemination, communication, and reflection on oral health, contributing in a relevant way to the technical-scientific interaction between professionals in this field.

  17. Factors Influencing Consent to Having Videotaped Mental Health Sessions

    Science.gov (United States)

    Ko, Kenton; Goebert, Deborah

    2011-01-01

    Objective: The authors critically reviewed the literature regarding factors influencing consent to having videotaped mental health sessions. Methods: The authors searched the literature in PubMed, PsycINFO, Google Scholar, and Web of Science from the mid-1950s through February 2009. Results: The authors identified 27 studies, of which 19 (73%)…

  18. Early Childhood Dental Caries: A Rising Dental Public Health Crisis

    Science.gov (United States)

    Gomez, Grace Felix

    2013-01-01

    The aim of this article is to examine the literature and review the risk factors and disparities contributing to early childhood caries (ECC), which is a major health problem among preschoolers in the United States of America. A search was conducted using MEDLINE, PubMed, Google Scholar, and the Cochrane Library databases and the key terms…

  19. Effects of student participation in school health promotion

    DEFF Research Database (Denmark)

    Griebler, Ursula; Rojatz, Daniela; Simovska, Venka

    2014-01-01

    rather than on student involvement at school in general. Participation is a core value for health promotion but empirical evidence of its outcomes is scarce. We searched major bibliographic databases (including ASSIA, ERIC, PsycINFO, Scopus, PubMed and the Social Sciences Citation Index). Two reviewers...

  20. Public health impact of the Volendam discotheque fire.

    NARCIS (Netherlands)

    Dorn, T.; IJzermans, C.J.

    2003-01-01

    Objective: The purpose of the study is to evaluate the pulic health impact of the 2001 Volendam discotheque fire. The fire occurred in an overcrowded pub in the Dutch city of Volendam where mostly young people were celebrating new year's eve. A total of 14 youngsters who were trapped in the fire die

  1. Public health impact of the Volendam discotheque fire.

    NARCIS (Netherlands)

    Dorn, T.; IJzermans, C.J.

    2003-01-01

    Objective: The purpose of the study is to evaluate the pulic health impact of the 2001 Volendam discotheque fire. The fire occurred in an overcrowded pub in the Dutch city of Volendam where mostly young people were celebrating new year's eve. A total of 14 youngsters who were trapped in the fire die

  2. Early Childhood Dental Caries: A Rising Dental Public Health Crisis

    Science.gov (United States)

    Gomez, Grace Felix

    2013-01-01

    The aim of this article is to examine the literature and review the risk factors and disparities contributing to early childhood caries (ECC), which is a major health problem among preschoolers in the United States of America. A search was conducted using MEDLINE, PubMed, Google Scholar, and the Cochrane Library databases and the key terms…

  3. Exposure to Fictional Medical Television and Health: A Systematic Review

    Science.gov (United States)

    Hoffman, Beth L.; Shensa, Ariel; Wessel, Charles; Hoffman, Robert; Primack, Brian A.

    2017-01-01

    Fictional medical television programs have long been a staple of television programming, and they remain popular today. We aimed to examine published literature assessing the influence of medical television programs on health outcomes. We conducted systematic literature searches in PubMed, PsychINFO and CINAHL. Selected studies had to be scholarly…

  4. Text-mining of PubMed abstracts by natural language processing to create a public knowledge base on molecular mechanisms of bacterial enteropathogens

    Directory of Open Access Journals (Sweden)

    Perna Nicole T

    2009-06-01

    Full Text Available Abstract Background The Enteropathogen Resource Integration Center (ERIC; http://www.ericbrc.org has a goal of providing bioinformatics support for the scientific community researching enteropathogenic bacteria such as Escherichia coli and Salmonella spp. Rapid and accurate identification of experimental conclusions from the scientific literature is critical to support research in this field. Natural Language Processing (NLP, and in particular Information Extraction (IE technology, can be a significant aid to this process. Description We have trained a powerful, state-of-the-art IE technology on a corpus of abstracts from the microbial literature in PubMed to automatically identify and categorize biologically relevant entities and predicative relations. These relations include: Genes/Gene Products and their Roles; Gene Mutations and the resulting Phenotypes; and Organisms and their associated Pathogenicity. Evaluations on blind datasets show an F-measure average of greater than 90% for entities (genes, operons, etc. and over 70% for relations (gene/gene product to role, etc. This IE capability, combined with text indexing and relational database technologies, constitute the core of our recently deployed text mining application. Conclusion Our Text Mining application is available online on the ERIC website http://www.ericbrc.org/portal/eric/articles. The information retrieval interface displays a list of recently published enteropathogen literature abstracts, and also provides a search interface to execute custom queries by keyword, date range, etc. Upon selection, processed abstracts and the entities and relations extracted from them are retrieved from a relational database and marked up to highlight the entities and relations. The abstract also provides links from extracted genes and gene products to the ERIC Annotations database, thus providing access to comprehensive genomic annotations and adding value to both the text-mining and annotations

  5. PMD2HD--a web tool aligning a PubMed search results page with the local German Cancer Research Centre library collection.

    Science.gov (United States)

    Bohne-Lang, Andreas; Lang, Elke; Taube, Anke

    2005-06-27

    Web-based searching is the accepted contemporary mode of retrieving relevant literature, and retrieving as many full text articles as possible is a typical prerequisite for research success. In most cases only a proportion of references will be directly accessible as digital reprints through displayed links. A large number of references, however, have to be verified in library catalogues and, depending on their availability, are accessible as print holdings or by interlibrary loan request. The problem of verifying local print holdings from an initial retrieval set of citations can be solved using Z39.50, an ANSI protocol for interactively querying library information systems. Numerous systems include Z39.50 interfaces and therefore can process Z39.50 interactive requests. However, the programmed query interaction command structure is non-intuitive and inaccessible to the average biomedical researcher. For the typical user, it is necessary to implement the protocol within a tool that hides and handles Z39.50 syntax, presenting a comfortable user interface. PMD2HD is a web tool implementing Z39.50 to provide an appropriately functional and usable interface to integrate into the typical workflow that follows an initial PubMed literature search, providing users with an immediate asset to assist in the most tedious step in literature retrieval, checking for subscription holdings against a local online catalogue. PMD2HD can facilitate literature access considerably with respect to the time and cost of manual comparisons of search results with local catalogue holdings. The example presented in this article is related to the library system and collections of the German Cancer Research Centre. However, the PMD2HD software architecture and use of common Z39.50 protocol commands allow for transfer to a broad range of scientific libraries using Z39.50-compatible library information systems.

  6. Effectiveness of Health Promotion Programmes for Truck Drivers: A Systematic Review

    Science.gov (United States)

    Ng, Mandy K.; Yousuf, Bilal; Bigelow, Philip Lloyd; Van Eerd, Dwayne

    2015-01-01

    Objective: To review the characteristics of effective health promotion interventions for reducing chronic diseases and their risk factors in truck drivers. Methods: MEDLINE (PubMed), SCOPUS, Web of Science Conference Proceedings, CINAHL (Cumulative Index to Nursing and Allied Health Literature), and the National Transportation Library were…

  7. Effectiveness of Health Promotion Programmes for Truck Drivers: A Systematic Review

    Science.gov (United States)

    Ng, Mandy K.; Yousuf, Bilal; Bigelow, Philip Lloyd; Van Eerd, Dwayne

    2015-01-01

    Objective: To review the characteristics of effective health promotion interventions for reducing chronic diseases and their risk factors in truck drivers. Methods: MEDLINE (PubMed), SCOPUS, Web of Science Conference Proceedings, CINAHL (Cumulative Index to Nursing and Allied Health Literature), and the National Transportation Library were…

  8. Impact of the 2008 economic and financial crisis on child health: A systematic review

    NARCIS (Netherlands)

    L. Rajmil (Luis); M.-J.F. de Sanmamed (María-José Fernandez); I. Choonara (Imti); T. Faresjö (Tomas); A. Hjern (Anders); A. Kozyrskyj (Anita); P.J. Lucas (Patricia); H. Raat (Hein); L. Séguin (Louise); N. Spencer (Nick); D. Taylor-Robinson (David)

    2014-01-01

    textabstractThe aim of this study was to provide an overview of studies in which the impact of the 2008 economic crisis on child health was reported. Structured searches of PubMed, and ISI Web of Knowledge, were conducted. Quantitative and qualitative studies reporting health outcomes on children, p

  9. 78 FR 53147 - Advisory Board on Radiation and Worker Health: Notice of Charter Renewal

    Science.gov (United States)

    2013-08-28

    ... HUMAN SERVICES Centers for Disease Control and Prevention (CDC) Advisory Board on Radiation and Worker Health: Notice of Charter Renewal This gives notice under the Federal Advisory Committee Act (Pub. L. 92-463) of October 6, 1972, that the Advisory Board on Radiation and Worker Health, Department of...

  10. Report: EPA Office of Inspector General’s Report on Reducing Fraud, Waste, and Abuse in the Small Business Innovative Research Program, as Required by the National Defense Authorization Act for Fiscal Year 2012, Pub. L. 112-81 (2012)

    Science.gov (United States)

    September 28, 2012. The EPA OIG is required by Section 5143 of the NDA Act for Fiscal Year 201 2, Pub. L. No. 112-81 (2012), to report on reducing vulnerability to fraud, waste and abuse in the Small Business Innovative Research (SBIR) program.

  11. The purification of Protein Elicitor PebC1 by TEV-LIC Clone and Expression System%使用TEV-LIC克隆与表达系统对蛋白激发子PebC1的纯化

    Institute of Scientific and Technical Information of China (English)

    刘权

    2011-01-01

    PebC1是来自于灰葡萄孢菌(Botrytis cinerea)的蛋白激发子,具有提高植物综合抗逆性的功能,可以开发为生物农药。由于该蛋白自身性质原因,如结合杂蛋白、形成二聚体等,难于得到纯蛋白,不利于进行进一步的研究。将该蛋白的编码基因克隆到TEV-LIC表达载体系统,并对该蛋白进行了表达,使用His标签和MBP标签进行亲和层析,然后通过TEV蛋白酶切去标签,用离子交换层析和分子筛层析得到高纯度的蛋白。本研究为PebC1的后续研究打下了基础,也为研究一些难于纯化的蛋白提供了新思路。%PebC1 is a protein elicitor from Botrytis cinerea.This protein can promote the overall stress tolerance of plant and can be developed as biological pesticide.But it was difficult to get purified protein for its own characters like binding peptides,forming homodimer etc,which would help forfurther study of PebC1.In this research,coding gene was cloned into a TEV-LIC system for expression.The fusion protein was purified by His and MBP tags affinity chromatography,then the tags was cut off by TEV protease.Finally,the high purity PebC1 was separated by ion-exchange and size-exclusive chromatography.This research laid foundation for the further research on PebC1 and shed new light on the research of proteins hard to be purified.

  12. Health care of youth aging out of foster care.

    Science.gov (United States)

    2012-12-01

    Youth transitioning out of foster care face significant medical and mental health care needs. Unfortunately, these youth rarely receive the services they need because of lack of health insurance. Through many policies and programs, the federal government has taken steps to support older youth in foster care and those aging out. The Fostering Connections to Success and Increasing Adoptions Act of 2008 (Pub L No. 110-354) requires states to work with youth to develop a transition plan that addresses issues such as health insurance. In addition, beginning in 2014, the Patient Protection and Affordable Care Act of 2010 (Pub L No. 111-148) makes youth aging out of foster care eligible for Medicaid coverage until age 26 years, regardless of income. Pediatricians can support youth aging out of foster care by working collaboratively with the child welfare agency in their state to ensure that the ongoing health needs of transitioning youth are met.

  13. Key LIC (Low Intensity Conflict) Speeches, 1984-1989

    Science.gov (United States)

    1989-09-01

    of refugees to the US. o It facilitates international criminals preying upon US citizens, as in cocaine trafficking. o It engages significant...prepared for low intensity threats. In football terms, this is the idea that, "If you can beat the varsity, you can beat the JV!" Of course, in... football , this is generally true. The prokW in low intensity conflict, to stretch the analogy slig’ is that the JV may not be playing football at all. In

  14. 20th Annual NDIA SO/LIC Symposium and Exhibition

    Science.gov (United States)

    2009-02-12

    Conjunto de Empleo Inmediato (DCEI) Description: A joint immediate response unit designed with a Battalion level staff, one Tactical Company, and a...Paraguay Destacamento Conjunto de Empleo Inmediato (DCEI) 10 UNCLAS//FOUO UNCLAS//FOUO Paraguay 11 UNCLAS//FOUO UNCLAS//FOUO President Lugo with

  15. 2010 JSOU and NDIA SO/LIC Division Essays

    Science.gov (United States)

    2010-05-01

    1990): 147-172; JSTOR database (accessed 26 April 2009). 18. Ibid., 149-150. 19. Valentine M. Moghadam, “Towards Gender Equality in the Arab...Gender Equality and Intrastate Armed Conflict,” International Studies Quarterly 49, No. 4 (2005): 695-714, 696; CSA database (accessed 14 May...2 (2005): 161-178, 165; CSA database (accessed 14 May 2009). 4. United Nations Division for the Advancement of Women, “Women 2000 and Beyond: The

  16. 2006 JSOU/NDIA SO/LIC Chapter Essays

    Science.gov (United States)

    2006-06-01

    leadership hides among the inert masses, directing an invisible network of operatives that stretches across multiple nation-states. The disparate...to achieve their political program. These attacks convulsed Europe for 20 years, but these groups eventually dissolved without succeeding. Not a

  17. JSOU and NDIA SO/LIC Division Essays (2007)

    Science.gov (United States)

    2007-04-01

    the area of micro credit. The recent Nobel Peace Prize awarded to Muhammad Yunus and his Grameen Bank highlights the recognized role in conflict...prevention and mitigation played by small-scale economic development.8 In addition to Gra- meen Bank , USAID and other international organizations are a

  18. 2011 JSOU and NDIA SO/LIC Division Essays

    Science.gov (United States)

    2011-07-01

    marines.org/gazette/article/marine-corps- intelligence-operations-anbar). 4. Hope Hodge , “Marines look to improve deployment-to-dwell ratios.” Jdnews...5. W.F. Lawless, Margo Bergman, J. Lou, Nicole Kriegel, and Nick Feltovich, “A Quantum Metric for Organizational Performance: Terrorism and...Dinsha Mistree, Stuart E. Mad- nick , Jay B. Morrison, Michael D. Siegel, Margaret Sweitzer-Hamilton, “Under- standing & Modeling State Stability

  19. 2012 JSOU and NDIA SO/LIC Division Essays

    Science.gov (United States)

    2012-07-01

    the five- times daily prayers are a time to trade gossip in these extremely illiterate, media-deficient communities and where Jummah prayers (Friday...efforts to rout foreign forces such as the British in the 19th century and to consolidate power as in the 1970s. The ulema shura (religious

  20. Residents and Medical Students Correctly Answer Clinical Questions More Often with Google and UpToDate than With PubMed or Ovid MEDLINE. A Review of: Thiele, R. H., Poiro, N. C., Scalzo, D. C., & Nemergut, E. C. (2010. Speed, accuracy, and confidence in Google, Ovid, PubMed, and UpToDate: Results of a randomised trial. Postgraduate Medical Journal, 86(1018, 459-465. doi:10.1136/pgmj.2010.098053

    Directory of Open Access Journals (Sweden)

    Theresa Arndt

    2011-06-01

    Full Text Available Objective – To determine which search tool (Google, UpToDate, PubMed or Ovid-MEDLINE produces more accurate answers for residents, medical students, and attending physicians searching on clinical questions in anesthesiology and critical care. Searcher confidence in the answers and speed with which answers were found were also examined.Design – Randomized study without a control group.Setting – Large university medical center.Subjects –Subjects included 15 fourth year medical students (third and fourth year, 35 residents, and 4 attending physicians volunteered and completed the study. One additional attending withdrew halfway through the study. The authors were unsuccessful in recruiting an equal number of subjects from each group.Methods – A set of eight anesthesia and critical care questions was developed, based on their commonality and importance in clinical practice and their answerability. Four search tools were employed: Google, UpToDate, PubMed, and Ovid MEDLINE. In part I, subjects were given a random set of four of the questions to answer with the search tool(s of their choice, but could use only one search tool per question. In part II, several weeks later, the same subjects were randomly assigned a search tool with which to answer all 8 questions. The authors state that “for data analysis, PubMed was arbitrarily chosen to be the “reference standard.”” Statistical analysis was used to identify significant differences between PubMed and the other search tools.Main Results – Part I: Subjects choosing a search tool were more likely to find a correct answer with Google or UpToDate. There were no statistically significant differences in confidence with answers between any of the search tools and PubMed.Part II: Though subjects were assigned a search tool, some questions were repeated from part I. For repeated questions, Ovid users (compared to PubMed users were significantly less likely to find the correct answer for

  1. PubMed数据库中(1979~2008)飞行员与心理疗法文献计量学分析%Bibliometric Analysis of Literatures of Pilot and Psychotherapy in PubMed during 1979-2008

    Institute of Scientific and Technical Information of China (English)

    孙涵雪; 刘旭峰; 许昌泰

    2011-01-01

    目的 对飞行员与心理学、心理疗法、行为疗法、精神分析疗法、认知疗法和森田疗法文献进行计量分析,以确定其文献增长规律和发展趋势.方法 登录www.ncbi.nlm.nih.gov/Pubmed(PubMed数据库)后用"pilot+psychology,pilot+psychotherapy,psychology,psychotherapy,behavior therapy,psychoanalytic therapy,cognitive therapy和Morita therapy"检索"从1979/01/01到 2008/12/31"文献量.根据科学文献增长规律的理论,对数据进行分析.结果 1979 ~2008年,PubMed数据库收录飞行员+心理学文献10 568篇,飞行员+心理疗法文献2038篇,心理学文献689 144篇,心理疗法文献92 086篇,行为疗法78 407篇,精神分析疗法9777篇,认知疗法33 775篇和森田疗法3547篇.对1979 ~2008年逐年累积文献量进行回归分析表明,心理学和心理疗法文献呈缓慢递增,其方程近似直线(Y=a+bX);而飞行员+心理学(心理疗法)文献上升缓慢,其方程近似于以e为底的指数方程:Y=43.996e0.1083x (10.434e0.0943x ).心理疗法文献以英语为主导(89.50%).结论 飞行员与心理学及心理疗法的研究仍是一个热点,影响心理学文献增长的主要因素是学科自身固有的规律和科所处的环境条件.%Objective We carried out a bibliometric analysis of pilot and psychotherapy literatures in aiming to determine its growth ruling and growth tendenc and to providing the basis for research problems in relation with psychotherapy.Methods We selected( PubMed databases,www.ncbi.nlm.nih.gov/Pubmed) literatures that contained key descriptors, including pilot and psychology, pilot and psychotherapy, behavior therapy, psychoanalytic therapy, cognitive therapy and Morita therapy, in their titles or papers from 1979 to 2008.As bibliometric indicators of psychotherapy we calculated the biomedical journals referring to psychotherapy.We applied the principal bibliometric indicators;Price's and Bradford's laws on the increase or dispersion of scientific

  2. Current status, hotspots and trends of optic neuritis research: Bibliometric analysis based on PubMed database%视神经炎研究现状、热点与趋势——基于PubMed数据库的文献计量分析

    Institute of Scientific and Technical Information of China (English)

    王伟; 张秀兰; 魏世辉

    2014-01-01

    背景 视神经炎研究领域近年来发展较快,分支较多且复杂,了解视神经炎相关研究现状、研究热点,预测未来发展趋势,对于相关的科研和临床工作均十分重要. 目的 了解视神经炎研究文献的分布规律、学科知识结构并预测未来发展趋势. 方法 利用PubMed数据库为数据源,对2000年1月至2012年7月收录的视神经炎相关文献进行统计分析,采用多元统计方法对高频主题词共现矩阵进行转换、降维和聚类分析,绘制战略坐标图,并根据社会网络分析方法绘制可视化网络图谱.结果 共检出视神经炎相关文献2 191篇,发文量逐年增加.美国、英国、德国、荷兰和日本5个国家总发文量为1 615篇,占发文总数的73.71%.相关高频主题词共52个,成功建立视神经炎学科知识可视化图谱,直观展示了视神经炎的知识分布,并形成重点研究聚类,结果显示当前的热点主要集中在9个领域,其中免疫学研究已经较为成熟但处于边缘的地位,视神经炎病因及诊断、病理学研究、病理生理学研究和视神经脊髓炎(NMO)专题研究是目前研究的核心领域,药物治疗、非中枢性脱髓鞘性视神经炎研究、流行病学研究和遗传学研究相对薄弱,有较大的提升空间.结论 近年国际上对视神经炎的关注和发文量逐年增加,欧美国家的发文量占主导地位.国际视神经炎的研究热点主要集中在9个领域,可能为今后研究的发展方向.%Background The research field of optic neuritis has developed rapidly and become more complex in recent years.It is very important for the reseachers and clinicians to known its status and the future trend.Objective This survey was to learn the distribution pattern,subject domain knowledge and worldwide research tendency of optic neuritis based on literatures in PubMed database.Methods Literatures on optic neuritis published in January 2000 to July 2012 were identified

  3. One Health and Zoonoses: The Evolution of One Health and Incorporation of Zoonoses

    Directory of Open Access Journals (Sweden)

    Govindaraj V. Asokan

    2015-07-01

    Full Text Available Introduction: Zoonotic disease outbreaks have surged in the last two decades. These include severe acute respiratory syndrome (SARS, Hendra virus, Nipah virus, influenza viruses, Middle East Respiratory Syndrome (MERS coronavirus, and ebola. One Health is the initiative of an inclusive collaboration linking human, animal, and environmental health. One Health is advocated through an intersectoral coordination to combat zoonoses, and the term has evolved over centuries. The primary aim of this literature review was to examine the change in the definition of the term One Health over time, particuarly following the the introduction of the latest definition in 2007 by the American Medical Association and the American Veterinary Medical Association.Methods: This review was conducted in four phases. The first phase consisted of a general PubMed search for the phrase “One Health” for every literature published up to December 2014. Then an advanced search was carried out using “One Health” in conjunction with the terms “zoonosis” and “zoonoses” in PubMed for the time period between January 2007 and December 2014.  The articles found were then categorized based on the type of journals in which the articles were published. For the second phase, “One Health” was searched as a Medical subject heading (MeSH term, which is the National Library of Medicine controlled vocabulary thesaurus used for indexing articles. In the third phase, One Health advocate organizations were found using Google search engine. During the final phase, One Health was searched in Google scholar, examined by Google trends, and analyzed by Google ngram.Results: Before 2007, One Health had many connotations to health in the medical literature with an incomplete adherence to the usage of One Health linking zoonoses. The Google trends analysis shows an overal steady increase of the search of One Health from 2007 to 2014, which is consistent with the findings of

  4. Tobacco control environment: cross-sectional survey of policy implementation, social unacceptability, knowledge of tobacco health harms and relationship to quit ratio in 17 low-income, middle-income and high-income countries.

    Science.gov (United States)

    Chow, Clara K; Corsi, Daniel J; Gilmore, Anna B; Kruger, Annamarie; Igumbor, Ehimario; Chifamba, Jephat; Yang, Wang; Wei, Li; Iqbal, Romaina; Mony, Prem; Gupta, Rajeev; Vijayakumar, Krishnapillai; Mohan, V; Kumar, Rajesh; Rahman, Omar; Yusoff, Khalid; Ismail, Noorhassim; Zatonska, Katarzyna; Altuntas, Yuksel; Rosengren, Annika; Bahonar, Ahmad; Yusufali, AfzalHussein; Dagenais, Gilles; Lear, Scott; Diaz, Rafael; Avezum, Alvaro; Lopez-Jaramillo, Patricio; Lanas, Fernando; Rangarajan, Sumathy; Teo, Koon; McKee, Martin; Yusuf, Salim

    2017-03-31

    This study examines in a cross-sectional study 'the tobacco control environment' including tobacco policy implementation and its association with quit ratio. 545 communities from 17 high-income, upper-middle, low-middle and low-income countries (HIC, UMIC, LMIC, LIC) involved in the Environmental Profile of a Community's Health (EPOCH) study from 2009 to 2014. Community audits and surveys of adults (35-70 years, n=12 953). Summary scores of tobacco policy implementation (cost and availability of cigarettes, tobacco advertising, antismoking signage), social unacceptability and knowledge were associated with quit ratios (former vs ever smokers) using multilevel logistic regression models. Average tobacco control policy score was greater in communities from HIC. Overall 56.1% (306/545) of communities had >2 outlets selling cigarettes and in 28.6% (154/539) there was access to cheap cigarettes (80% of participants disapproved youth smoking (95.7% HIC, 57.6% UMIC, 76.3% LMIC and 58.9% LIC). The average knowledge score was >80% in 48.4% of communities (94.6% HIC, 53.6% UMIC, 31.8% LMIC and 35.1% LIC). Summary scores of policy implementation, social unacceptability and knowledge were positively and significantly associated with quit ratio and the associations varied by gender, for example, communities in the highest quintile of the combined scores had 5.0 times the quit ratio in men (Odds ratio (OR) 5·0, 95% CI 3.4 to 7.4) and 4.1 times the quit ratio in women (OR 4.1, 95% CI 2.4 to 7.1). This study suggests that more focus is needed on ensuring the tobacco control policy is actually implemented, particularly in LMICs. The gender-related differences in associations of policy, social unacceptability and knowledge suggest that different strategies to promoting quitting may need to be implemented in men compared to women. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  5. Costs to Health Services and the Patient of Treating Tuberculosis: A Systematic Literature Review.

    Science.gov (United States)

    Laurence, Yoko V; Griffiths, Ulla K; Vassall, Anna

    2015-09-01

    Novel tuberculosis (TB) drugs and the need to treat drug-resistant tuberculosis (DR-TB) are likely to bring about substantial transformations in TB treatment in coming years. An evidence base for cost and cost-effectiveness analyses of these developments is needed. Our objective was to perform a review of papers assessing provider-incurred as well as patient-incurred costs of treating both drug-susceptible (DS) and multidrug-resistant (MDR)-TB. Five databases (EMBASE, Medline, the National Health Service Economic Evaluation Database, the Cost-Effectiveness Analysis Registry, and Latin American and Caribbean Health Services Literature) were searched for cost and economic evaluation full-text papers containing primary DS-TB and MDR-TB treatment cost data published in peer-reviewed journals between January 1990 and February 2015. No language restrictions were set. The search terms were a combination of 'tuberculosis', 'multidrug-resistant tuberculosis', 'cost', and 'treatment'. In the selected papers, study methods and characteristics, quality indicators and costs were extracted into summary tables according to pre-defined criteria. Results were analysed according to country income groups and for provider costs, patient costs and productivity losses. All values were converted to $US, year 2014 values, so that studies could be compared. We selected 71 treatment cost papers on DS-TB only, ten papers on MDR-TB only and nine papers that included both DS-TB and MDR-TB. These papers provided evidence on the costs of treating DS-TB and MDR-TB in 50 and 16 countries, respectively. In 31 % of the papers, only provider costs were included; 26 % included only patient-incurred costs, and the remaining 43 % estimated costs incurred by both. From the provider perspective, mean DS-TB treatment costs per patient were US$14,659 in high-income countries (HICs), US$840 in upper middle-income countries (UMICs), US$273 in lower middle-income (LMICs), and US$258 in low-income countries

  6. Demographic and Socioeconomic Characteristics Among Primary Health Care Users Diagnosed with Osteoarthritis in Albania

    NARCIS (Netherlands)

    Hoxha, F.; Tafaj, A.; Roshi, E.; Burazeri, G.

    2015-01-01

    Demographic and Socioeconomic Characteristics Among Primary Health Care Users Diagnosed with Osteoarthritis in Albania. Hoxha F, Tafaj A, Roshi E, Burazeri G. Mater Sociomed. 2015 Jun;27(3):163-6. doi: 10.5455/msm.2015.27.163-166. Epub 2015 Jun 8. PMID: 26236161 [PubMed] Free PMC Article

  7. 78 FR 69682 - Board of Scientific Counselors, Office of Public Health Preparedness and Response: Notice of...

    Science.gov (United States)

    2013-11-20

    ... HUMAN SERVICES Centers for Disease Control and Prevention Board of Scientific Counselors, Office of Public Health Preparedness and Response: Notice of Charter Renewal This gives notice under the Federal Advisory Committee Act (Pub. L. 92-463) of October 6, 1972, that the Board of Scientific Counselors,...

  8. 76 FR 9577 - Board of Scientific Counselors, National Institute for Occupational Safety and Health: Notice of...

    Science.gov (United States)

    2011-02-18

    ... HUMAN SERVICES Centers for Disease Control and Prevention Board of Scientific Counselors, National Institute for Occupational Safety and Health: Notice of Charter Renewal This gives notice under the Federal Advisory Committee Act (Pub. L. 92-463) of October 6, 1972, that the Board of Scientific...

  9. 78 FR 6328 - Board of Scientific Counselors, National Center for Health Statistics: Notice of Charter Renewal

    Science.gov (United States)

    2013-01-30

    ... HUMAN SERVICES Centers for Disease Control and Prevention Board of Scientific Counselors, National Center for Health Statistics: Notice of Charter Renewal This gives notice under the Federal Advisory Committee Act (Pub. L. 92-463) of October 6, 1972, that the Board of Scientific Counselors, National...

  10. 76 FR 77235 - Board of Scientific Counselors, Office of Public Health Preparedness and Response: Notice of...

    Science.gov (United States)

    2011-12-12

    ... HUMAN SERVICES Centers for Disease Control and Prevention Board of Scientific Counselors, Office of Public Health Preparedness and Response: Notice of Charter Renewal This gives notice under the Federal Advisory Committee Act (Pub. L. 92-463) of October 6, 1972, that the Board of Scientific Counselors,...

  11. Public health spending and population health: a systematic review.

    Science.gov (United States)

    Singh, Simone R

    2014-11-01

    This systematic review synthesizes what is known about the relationship between public health spending and population health outcomes, as well as the pathways that may explain how outcomes vary with spending. It also discusses the limitations of the existing literature and identifies areas in need of future research. Studies included in this review were retrieved through an iterative process, primarily through key word searches in two literature databases (PubMed and JSTOR) conducted in 2013. All retrieved studies underwent initial and secondary screening. Articles were included if they (1) examined the link between spending and outcomes or (2) explored pathways that mediate the relationship between spending and outcomes. Seventeen empirical studies and five literature reviews published between 1985 and 2012 were included in this review. Existing evidence suggests that increases in public health spending are associated with improved population health, at least for some outcomes. However, there is little evidence to suggest that increased spending contributes to meaningful reductions in health disparities. Moreover, the pathways through which greater spending translates into better outcomes are not well understood. Although the complexity of the public health delivery system makes it difficult to demonstrate definitive associations between spending and outcomes, financial investments in public health have the potential to improve community health. Additional research is needed to explore the pathways that mediate this relationship. This research would benefit public health practitioners who need evidence on how to best spend financial resources to achieve better health outcomes. Copyright © 2014 American Journal of Preventive Medicine. Published by Elsevier Inc. All rights reserved.

  12. Creating customer value and the use of the product life cycle to generate strategic options for maturing low-cost service-retail markets -A case study on The Spirit Group value pub food retail concept"Two for One"

    OpenAIRE

    2007-01-01

    This is a case study on a low-cost service retail concept known as "Two for One" a pub-food chain owned by The Spirit Group. The thesis aims to explore the nature and characteristics of the product life cycle for low-cost service retailers with the objective to establish strategic options. The nature of low-cost propositions is that price is the main strategic driver to compete for growth and market share. However in maturing markets where competition is high and margins are low, retailers...

  13. Preventive occupational health interventions in the meat processing industry in upper-middle and high-income countries : a systematic review on their effectiveness

    NARCIS (Netherlands)

    van Holland, Berry J.; Soer, Remko; de Boer, Michiel R.; Reneman, Michiel F.; Brouwer, Sandra

    2015-01-01

    OBJECTIVE: To investigate the effectiveness of occupational health interventions in the meat processing industry on work and health-related outcomes. METHODS: A systematic literature review was performed. PubMed, Embase, and The Cochrane Library were searched. Studies were included when they

  14. The Time Is Now: Attention Increases to Transgender Health in the United States but Scientific Knowledge Gaps Remain.

    Science.gov (United States)

    MacCarthy, Sarah; Reisner, Sari L; Nunn, Amy; Perez-Brumer, Amaya; Operario, Don

    2015-12-01

    Attention to transgender health has dramatically increased in the U.S. Scientific knowledge gaps in empirical research, however, remain and act as barriers to achieving transgender-related health equity. We conducted a search using PubMed and PsycINFO to identify gaps in empirical, peer-reviewed publications related to adult transgender health in the U.S. between 1981 and 2013. We synthesized these findings and commented on opportunities for improving health research. Reducing health disparities and advancing transgender-related health equity requires greater investment in research that addresses current gaps to more comprehensively respond to the diverse health needs of transgender people.

  15. 有关糖尿病神经病变的文献计量学分析:2003~2012%The bibliometrics analysis of diabetic neuropathy in PubMed database from 2003 to 2012

    Institute of Scientific and Technical Information of China (English)

    李梅玲; 贾敏; 郭丽; 伍建斌; 毛培军

    2014-01-01

    目的 掌握目前糖尿病神经病变(DN)发展现状和趋势. 方法 采用文献计量学方法对PubMed中2003~2012年收录的关于DN方面的文献进行分析.统计2003年1月至2012年12月PubMed共收录DN的文献数量.对文献数量行线性回归分析,得到DN的总文献量的变化趋势(y=21.43x+528.53). 结果 文献主要以英文为主并逐年稳步递增. 结论 既往研究主要仍以糖尿病周围神经病变(DPN)研究为主.研究已从临床转向基础研究,研究的热点和方向主要集中在DN的治疗、病理生理学、病因学等方面.

  16. A Review of Factors Influencing Health Inequalities

    Directory of Open Access Journals (Sweden)

    Hassan Almaspoor Khanghah

    2016-01-01

    Full Text Available ​Background and Objectives : Inequity in health is a universal term which is used for showing current differences, variations and inequalities of people in accessing to health services. The current study aimed to assess the factors influencing health inequalities to present the results to the researchers and health care professionals. Material and Methods : In this review, several databases including PubMed, Proquest, Scopus, Google Scholar search engine, SID and IranDoc were searched within 2000-2014 period. We found 746 articles and refined them step by step according to the aim of the study by reviewing the titles, abstracts and full texts. Finally, 16 articles were selected for further study Results: In the present study, identified determinants in health inequalities were as follows: 1- Economic and income factors 2- Political factors, social and public policy 3- Cultural and social values 4- social and demographic factors 5- Behavioral, psychological and biological factors. Although, other factors like governmental, international, social cohesion, incidents and even the health system itself were involved in health inequalities, but the listed determinants were among the most important determinants in health inequalities in the conducted studies. Conclusion : Given the importance of people's health and inequalities in health, the approach should focus on reducing the inequalities in all policies and development programs and the role of these factors should be taken into consideration by managers and policy-makers

  17. Sexual Health

    Science.gov (United States)

    ... Basic HIV/AIDS information and resources for prevention LGBT Health Information for lesbian, gay, bisexual, or transgender (LGBT) individuals Sexual Health News & Information Understanding Sexual Health ...

  18. mHealth Interventions for Health System Strengthening in China: A Systematic Review

    Science.gov (United States)

    Zhang, Jing; Luo, Rong; Chen, Shi; Petrovic, Djordje; Redfern, Julie; Xu, Dong Roman; Patel, Anushka

    2017-01-01

    Background With rapidly expanding infrastructure in China, mobile technology has been deemed to have the potential to revolutionize health care delivery. There is particular promise for mobile health (mHealth) to positively influence health system reform and confront the new challenges of chronic diseases. Objective The aim of this study was to systematically review existing mHealth initiatives in China, characterize them, and examine the extent to which mHealth contributes toward the health system strengthening in China. Furthermore, we also aimed to identify gaps in mHealth development and evaluation. Methods We systematically reviewed the literature from English and Chinese electronic database and trial registries, including PubMed, EMBASE, Cochrane, China National Knowledge of Infrastructure (CNKI), and World Health Organization (WHO) International Clinical Trials Registry Platform. We used the English keywords of mHealth, eHealth, telemedicine, telehealth, mobile phone, cell phone, text messaging, and China, as well as their corresponding Chinese keywords. All articles using mobile technology for health care management were included in the study. Results A total of 1704 articles were found using the search terms, and eventually 72 were included. Overall, few high quality interventions were identified. Most interventions were found to be insufficient in scope, and their evaluation was of inadequate rigor to generate scalable solutions and provide reliable evidence of effectiveness. Most interventions focused on text messaging for consumer education and behavior change. There were a limited number of interventions that addressed health information management, health workforce issues, use of medicines and technologies, or leadership and governance from a health system perspective. Conclusions We provide four recommendations for future mHealth interventions in China that include the need for the development, evaluation and trials examining integrated mHealth

  19. Health Economics of Dengue: A Systematic Literature Review and Expert Panel's Assessment

    OpenAIRE

    Mark E Beatty; Beutels, Philippe; Meltzer, Martin I.; Donald S Shepard; Hombach, Joachim; Hutubessy, Raymond; Dessis, Damien; Coudeville,Laurent; Dervaux, Benoit; Wichmann, Ole; Margolis, Harold S.; Kuritsky, Joel N.

    2011-01-01

    Dengue vaccines are currently in development and policymakers need appropriate economic studies to determine their potential financial and public health impact. We searched five databases (PubMed, EMBASE, LILAC, EconLit, and WHOLIS) to identify health economics studies of dengue. Forty-three manuscripts were identified that provided primary data: 32 report economic burden of dengue and nine are comparative economic analyses assessing various interventions. The remaining two were a willingness...

  20. Instagram and WhatsApp in Health and Healthcare: An Overview

    Directory of Open Access Journals (Sweden)

    Maged N. Kamel Boulos

    2016-07-01

    Full Text Available Instagram and WhatsApp are two social media and networking services introduced in 2010. They are currently subsidiaries of Facebook, Inc., California, USA. Using evidence from the published literature and case reports indexed in PubMed and other sources, we present an overview of the various applications of Instagram and WhatsApp in health and healthcare. We also briefly describe the main issues surrounding the uses of these two apps in health and medicine.