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Sample records for ptc heater means

  1. STUDY ON THE OPTIMIZATION OF IGBT THERMAL MANAGEMENT FOR PTC HEATER

    Directory of Open Access Journals (Sweden)

    J. W. JEONG

    2015-12-01

    Full Text Available It is essential to optimize HVAC (Heating, Ventilation and Air-Conditioning system for a thermal plant or an electric vehicle since it has a significant effect on the thermal efficiency. PTC (positive temperature coefficient heaters are often used for a heating system and the power module of the PTC heaters, IGBT (insulated gate bipolar mode transistor, requires thermal management. In this study, in order to maximize the cooling performance for IGBT, a novel method that uses forced convection inside the HVAC duct with heat sinks was developed. In addition, heat sinks were optimized in terms of IGBT junction temperature and heat sink weight by 3-dimensional CFD (Computational Fluid Dynamics simulation. The results show that the junction temperature of IGBT for 5.6kW PTC heater can be maintained at about 335K.

  2. PTC

    African Journals Online (AJOL)

    Ruqaiya Hussain

    2013-07-25

    Jul 25, 2013 ... of PTC taste sensitivity among some Muslim populations of North India, as till now no detailed information is available. .... provided the basis for a new, integrative investigation of PTC .... This trait is of genetic, epidemiologic and evolutionary interest .... ABO blood group, PTC taste ability, and red-green color.

  3. PTC

    African Journals Online (AJOL)

    Ruqaiya Hussain

    2013-07-25

    Jul 25, 2013 ... adopted as per the sorting technique of serial dilutions of. Harris and Kalmus [16] .... ABO blood group, PTC taste ability, and red-green color · blindness. Biol Bull .... related to coffee as a dietary source of niacin. Chem Senses.

  4. 49 CFR 236.1027 - PTC system exclusions.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false PTC system exclusions. 236.1027 Section 236.1027... Systems § 236.1027 PTC system exclusions. (a) The requirements of this subpart apply to each office... PTC system. For purposes of this section, “office automation system” means any centralized or...

  5. Influence of γ-ray Irradiation on the PTC Effect of EPDM/Carbon Black Composite

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    @@ Introduction The positive temperature coefficient(PTC) effect is characterized by an increase of resistivity with an elevated temperature.The PTC effect of carbon black(CB) filled polymers is useful for self-regulation heaters,over-current protectors,sensors,etc.Much work has been done on the PTC effect of the carbon black filled crystalline polymer composite[1-4],whereas carbon black filled amorphous polymers have not drawn researchers much attention because the PTC effect in these composites is small or cannot be detected[5-7].In this work,the influence of γ-ray irradiation on the PTC effect of CB filled amorphous ethylene-propylene-diene terpolymer(EPDM) composites was studied.

  6. Performance Characteristics of PTC Elements for an Electric Vehicle Heating System

    Directory of Open Access Journals (Sweden)

    Yoon Hyuk Shin

    2016-10-01

    Full Text Available A high-voltage positive temperature coefficient (PTC heater has a simple structure and a swift response. Therefore, for cabin heating in electric vehicles (EVs, such heaters are used either on their own or with a heat pump system. In this study, the sintering process in the manufacturing of PTC elements for an EV heating system was improved to enhance surface uniformity. The electrode production process entailing thin-film sputtering deposition was applied to ensure the high heating performance of PTC elements and reduce the electrode thickness. The allowable voltage and surface heat temperature of the high-voltage PTC elements with thin-film electrodes were 800 V and 172 °C, respectively. The electrode layer thickness was uniform at approximately 3.8 μm or less, approximately 69% less electrode materials were required compared to that before process improvement. Furthermore, a heater for the EV heating system was manufactured using the developed high-voltage PTC elements to verify performance and reliability.

  7. Fitting mixture distributions to phenylthiocarbamide (PTC) sensitivity.

    OpenAIRE

    Jones, P N; G.J. McLachlan

    1991-01-01

    A technique for fitting mixture distributions to phenylthiocarbamide (PTC) sensitivity is described. Under the assumptions of Hardy-Weinberg equilibrium, a mixture of three normal components is postulated for the observed distribution, with the mixing parameters corresponding to the proportions of the three genotypes associated with two alleles A and a acting at a single locus. The corresponding genotypes AA, Aa, and aa are then considered to have separate means and variances. This paper is c...

  8. HDPE/EPDM/CB复合物的PTC效应%PTC Effect in HDPE/EPDM/CB Composites

    Institute of Scientific and Technical Information of China (English)

    赫秀娟; 陈欣方; 王丽杰; 刘志城

    2001-01-01

    Polymer positive temperature coefficient(PTC) material comprising conductive particles,e.g.carbon black (CB),dispersed in polymer matrix is suitable for use as electrical devices such as circuit overcurrent protection device,self-regulation heaters,sensors,etc..In this paper,the PTC effect of carbon black filled polyethylene and ethylene-propylene-diene terpolymer blends was studied.Effects of raw material ratio and type of carbon black were investigated.The distribution of CB in polymer matrix and the function of crystallites on PTC effect were discussed.

  9. MAD-X PTC Integration

    CERN Document Server

    Schmidt, Frank; Goddard, B; Jacquet, D; Kain, V; Lamont, M; Mertens, V; Uythoven, J; Wenninger, J

    2005-01-01

    MAD-X is CERN's successor for MAD8, a program for accelerator design with a long history. MAD-X is a modular, better maintainable re-write of MAD8 with data structures written in `C'. Early on in the design of MAD-X we relied on the fact that older or doubtful modules could be replaced by new modules using the PTC code by E. Forest. Both codes remain independent entities but are linked via a converter to the MAD-X data structures. PTC is used for symplectic tracking of smaller machines and transfer line using better defined physical models of the elements and taking into account of how the elements are placed in the tunnel. The matching of the LHC will profit form the fact that the high order nonlinear parameters are provided by a PTC Normal Form analysis.

  10. 49 CFR 236.1031 - Previously approved PTC systems.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Previously approved PTC systems. 236.1031 Section... Train Control Systems § 236.1031 Previously approved PTC systems. (a) Any PTC system fully implemented and operational prior to March 16, 2010, may receive PTC System Certification if the applicable PTC...

  11. Effectiveness of different formulations of Endo-PTC to promote root canal cleaning.

    Science.gov (United States)

    Rodrigues, Evaldo; Albergaria, Sílvio; Barbosa, Gabriela L R; Santoro, Mariana; Pacheco, Paulo; Leal Silva, Emmanuel João Nogueira

    2015-01-01

    Endo-PTC are used during endodontic treatment; however, until now no study evaluated the cleaning of dentin walls after use of different Endo-PTC formulations. The aim of this study was to assess qualitatively, by means of scanning electron microscopy (SEM) images, the cleaning of dentin walls of root canals after chemomechanical preparation (CMP) using Endo-PTC cream and Endo-PTC light associated to 2.5% sodium hypochlorite and 17% ethylenediamine tetraacetate (EDTA). Forty single-rooted human maxillary central incisors with straight canals and fully formed apex were selected. The specimens were randomly divided into four groups depending on the type of Endo-PTC and the final rinse with 17% EDTA. After CMP, all specimens were sectioned and processed for observation of the apical thirds by using SEM. Three calibrated evaluators attributed scores to each specimen. The differences between irrigation protocols were analyzed with Kruskal-Wallis test followed by Bonferroni adjustment for multiple comparisons. The significance level was set at α = 0.05. The use of Endo-PTC cream or Endo-PTC light did not influence the smear-layer (SL) removal (P > 0.05). When EDTA were used, it was obtained the best cleaning results with no significant difference between the substances (P PTC formulation.

  12. PERCEPTION OF TASTE OF PHENYLTHIOUREA (PTC).

    Science.gov (United States)

    Examining 213 students of the first year at the faculty (3/4 women), 24.88% were found nontasting PTC . The differences between sexes are not...represented. With a quinine control test among nontasting, a small correlation to PTC was established. The results are in agreement with literature data. (Author)

  13. Phenylthiocarbamide (PTC) Tasting and Reported Depression.

    Science.gov (United States)

    Whittemore, Paul B.

    1986-01-01

    The phenylthiocarbamide (PTC) taste test was investigated for its potential as a genetically based biological marker for depression. Results indicated PTC tasters reported significantly higher levels of depression on the Beck Depression Inventory (BDI) than nontasters and they scored higher on 5 of the 21 items. (Author/BL)

  14. Transparent electric convection heater

    OpenAIRE

    Khalid, A.; Luck, J.L.

    2001-01-01

    An optically transparent electrically heated convection heater for use as a space heater in homes, offices, shops. Typically, said convection heater consists of a transparent layer 1 upon which is deposited a layer of a transparent electrically conductive material 2 such as indium-tin-oxide, electrodes 3 and 3a are formed on opposite edges of the transparent electrically conductive layer 2 and electrical wires 4 and 4a are connected to the electrodes. The transparent electrically conductive l...

  15. Grouped exposed metal heaters

    Energy Technology Data Exchange (ETDEWEB)

    Vinegar, Harold J [Bellaire, TX; Coit, William George [Bellaire, TX; Griffin, Peter Terry [Brixham, GB; Hamilton, Paul Taylor [Houston, TX; Hsu, Chia-Fu [Granada Hills, CA; Mason, Stanley Leroy [Allen, TX; Samuel, Allan James [Kular Lumpar, ML; Watkins, Ronnie Wade [Cypress, TX

    2012-07-31

    A system for treating a hydrocarbon containing formation is described. The system includes two or more groups of elongated heaters. The group includes two or more heaters placed in two or more openings in the formation. The heaters in the group are electrically coupled below the surface of the formation. The openings include at least partially uncased wellbores in a hydrocarbon layer of the formation. The groups are electrically configured such that current flow through the formation between at least two groups is inhibited. The heaters are configured to provide heat to the formation.

  16. Grouped exposed metal heaters

    Energy Technology Data Exchange (ETDEWEB)

    Vinegar, Harold J. (Bellaire, TX); Coit, William George (Bellaire, TX); Griffin, Peter Terry (Brixham, GB); Hamilton, Paul Taylor (Houston, TX); Hsu, Chia-Fu (Granada Hills, CA); Mason, Stanley Leroy (Allen, TX); Samuel, Allan James (Kular Lumpar, MY); Watkins, Ronnie Wade (Cypress, TX)

    2010-11-09

    A system for treating a hydrocarbon containing formation is described. The system includes two or more groups of elongated heaters. The group includes two or more heaters placed in two or more openings in the formation. The heaters in the group are electrically coupled below the surface of the formation. The openings include at least partially uncased wellbores in a hydrocarbon layer of the formation. The groups are electrically configured such that current flow through the formation between at least two groups is inhibited. The heaters are configured to provide heat to the formation.

  17. RET/PTC rearrangement in benign and malignant thyroid diseases: a clinical standpoint.

    Science.gov (United States)

    Marotta, Vincenzo; Guerra, Anna; Sapio, Maria Rosaria; Vitale, Mario

    2011-10-01

    Cytological examination of fine needle aspiration biopsy is the primary means for distinguishing benign from malignant nodules. However, as inconclusive cytology is very frequent, the introduction of molecular markers in the preoperative diagnosis of thyroid nodules has been proposed in recent years. In this article, we review the clinical implications of preoperative detection of rearrangements of the RET gene (RET/papillary thyroid carcinoma (PTC)) in thyroid nodules. The prevalence of RET/PTC in PTC depends on the histological subtypes, geographical factors, radiation exposure, and detection method. Initially, RET/PTC was considered an exclusive PTC hallmark and later it was also found sporadically in benign thyroid lesions. More recently, the very sensitive detection methods, interphase fluorescence in situ hybridization (FISH) and Southern blot on RT-PCR amplicons, demonstrated that the oligoclonal occurrence of RET rearrangement in benign thyroid lesions is not a rare event and suggested that it could be associated with a faster enlargement in benign nodules. For this reason, RET/PTC cannot be considered as an absolute marker of PTC, and its diagnostic application must be limited to assays able to distinguish between clonal and oligoclonal expression. Detection of RET/PTC by quantitative assays will be useful for diagnostic purposes in cytology specimens when a precise cutoff will be fixed in a clinical setting. Until that time, less sensitive RET/PTC detection methods and FISH analysis remain the most appropriate means to refine inconclusive cytology. Future studies with a long follow-up will further clarify the clinical significance of low level of RET rearrangements in benign nodules.

  18. PTC thermistor protects multiloaded power supplies

    Science.gov (United States)

    Leverone, H.; Mandell, N.

    1964-01-01

    A PTC /Positive-Temperature-Coefficient/ thermistor placed in series with each branch load of a multiload circuit prevents power loss in parallel branches. This thermistor may be used in any circuit requiring current limiting or intended overload resetting.

  19. Advances in MAD-X using PTC

    CERN Document Server

    Skowronski, P K; Forest, E

    2007-01-01

    For the last few years the MAD-X program makes use of the Polymorphic Tracking Code (PTC) to perform calculations related to beamdynamics in the nonlinear regime. An important new feature is the extension of the matching module to allow fitting of non-linear parameters to any order. Moreover, calculations can now be performed with parameter dependence defined in the MAD-X input. In addition, the user can access the PTC routines for the placement of a magnet with arbitrary position and orientation. This facilitates the design of non-standard lattices, in particular since a 3D visualization of a lattice is now available. For the LHC studies during commissioning it is of special interest that one has access to within the thick PTC elements which allows e.g. to find PTC Twiss parameters at any point in the ring.

  20. 49 CFR 236.1011 - PTC Implementation Plan content requirements.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false PTC Implementation Plan content requirements. 236... Positive Train Control Systems § 236.1011 PTC Implementation Plan content requirements. Link to an...) How the PTC railroad intends to comply with §§ 236.1009(c) and (d); (3) How the PTC system will...

  1. Thermal storage heaters

    Energy Technology Data Exchange (ETDEWEB)

    Stokes, K.H.; Broadbent, J.T.

    1991-02-27

    A storage heater, providing heat by radiation, comprises an internal circuit for the passage of heated air. The heater comprises: a heat storage core, comprising heat storage rods heated by resistance wiring, and an air space around the rods, the air space forming an inner pathway of circuit; heat insulation around the core; and outer pathways adjacent outer walls of the heater. A damper is arranged at the top of the inner and outer pathways to control the communication between. The damper may be movably supported on a support part by robust bi-metallic strips wound with heater wires to control the bending of the strips. The storage heater may be supplied in kit form for the purchaser to assemble and to this end the heat storage rods may comprise particulate material poured into tubes, or liftable core units. Further heat insulation may be selectively positioned in the outer pathways to provide an even heat distribution. (author).

  2. [Diagnostic value of BRAFV600E and RET/PTC oncogenes in thyroid nodule aspirates].

    Science.gov (United States)

    Guerra, Anna; Carrano, Mario; Angrisani, Elisabetta; Vitale, Mario

    2013-01-01

    Fine-needle aspiration cytology (FNC) is the primary means to distinguish benign form malignant nodules. Aim of this study is to evaluate the diagnostic value of BRAF(V600E) and RET/PTC oncogenes in a large cohort of thyroid nodules with inconclusive FNC. We searched for BRAF(V600E) and RET/PTC in 299 thyroid nodule aspirates then removed by surgery. RET/PTC demonstrated a poor specificity. The search for BRAF(V600E) demonstrated to be useful in 25 cases, identifying a PTC in 2 false negative, 2 inadequate, 11 indeterminate and 10 suspicious FNC. Detection of BRAF(V600E) revealed to be a useful tool to refine inconclusive cytology.

  3. Comparison of C4d detection on erythrocytes and PTC-C4d to histological signs of antibody-mediated rejection in kidney transplantation.

    Science.gov (United States)

    Haidar, F; Kisserli, A; Tabary, T; McGregor, B; Noel, L H; Réveil, B; Toupance, O; Rieu, P; Thervet, E; Legendre, C; Morelon, E; Issa, N; Cohen, J H M

    2012-06-01

    C4d on erythrocytes (EC4d), C4d peritubular capillary deposition (PTC-C4d) staining and histology were compared in a cross-sectional cohort of 146 renal allograft biopsies (132 patients). EC4d levels paralleled PTC-C4d staining, but were more predictive of peritubular capillaritis (PTC). Donor-specific antibodies (DSA), PTC-C4d, EC4d and PTC were analyzed in an independent longitudinal follow-up cohort (96 biopsies, 76 patients). Seventy-six samples were PTC and EC4d concordant, 11 positive and 65 negative, 7 PTC-EC4d+ and 13 PTC+EC4d-. EC4d levels were related to DSA occurrence. With ABMR defined by PTC and DSA, all apparently discordant patients, EC4d negative, were correctly reassigned comparing EC4d level curves with rejection kinetics, with positive EC4d samples predating biopsy or late biopsies compared with ABMR flare-ups. All EC4d-positive patients without PTC or DSA had permanent high EC4d levels unrelated to rejection. EC4d was more abundant in PTC-positive (mean = 108.5%± 3.4; n = 50) than PTC-negative samples (mean = 88.1%± 1.3; n= 96; p PTC-C4d and EC4d for PTC were, respectively, 75%, 79%; 64%, 76% (p < 0.05); 28%, 46% (p < 0.05) and 93%, 94%. Values were similar for DSA. A noninvasive blood test, EC4d, and particularly longitudinally monitoring EC4d levels, may increase surrogate ABMR testing options. © Copyright 2012 The American Society of Transplantation and the American Society of Transplant Surgeons.

  4. Explosives tester with heater

    Science.gov (United States)

    Del Eckels, Joel [Livermore, CA; Nunes, Peter J [Danville, CA; Simpson, Randall L [Livermore, CA; Whipple, Richard E [Livermore, CA; Carter, J Chance [Livermore, CA; Reynolds, John G [San Ramon, CA

    2010-08-10

    An inspection tester system for testing for explosives. The tester includes a body and a swab unit adapted to be removeably connected to the body. At least one reagent holder and dispenser is operatively connected to the body. The reagent holder and dispenser contains an explosives detecting reagent and is positioned to deliver the explosives detecting reagent to the swab unit. A heater is operatively connected to the body and the swab unit is adapted to be operatively connected to the heater.

  5. A Study on Prevalence of Phenyl Thiocarbamide (PTC) Taste Blindness Among Obese Individuals.

    Science.gov (United States)

    Veluswami, Deepika; Meena, B Ambigai; Latha, S; Fathima, I Gayathri; Soundariya, K; Selvi, K Senthamil

    2015-05-01

    Taste blindness to the phenylthiocarbamide (PTC) is an inherited trait that is shown to influence our food and dietary preferences which in turn influence our body weight. Obesity is a global epidemic issue known to be on rise among the developing countries. Relating taste perception to obesity, the present study was undertaken to assess the prevalence of phenylthiocarbamide (PTC) taste blindness among obese individuals. Three hundred and fifty individuals of age group 20-40 y were recruited from the local community for the present cross sectional study. Anthropometric measurements were taken and BMI was calculated. Subjects were classified as underweight, normal, overweight and obese based on their BMI. Normal, overweight and obese individuals were then asked to taste the commercially available PTC test papers and classified as non tasters and tasters of PTC. Out of 350 individuals, mean age group of 30±6.02 y, based on their BMI they were divided into 4 groups, Group A-underweight (16%), Group B-normal (35%), Group C-overweight (28%) and Group D-obese (21%) individuals. In group B, 28% were non tasters of PTC and 65% were tasters. In group C, 82% were non tasters and 13% were tasters and in Group D, 81% were non tasters and 19% were tasters of PTC. The PTC non taster phenotype individuals showed higher BMI as compared with the tasters' phenotype. Exploring the novel connections between taste perception and obesity would help us to gain a control over the global epidemic-Obesity, which is the crux factor for various other health problems. The study advocates the usage of PTC tasting as a reliable indicator of weight gain susceptibility.

  6. Pt/C Fuel Cell Catalyst Degradation

    DEFF Research Database (Denmark)

    Zana, Alessandro

    This thesis investigates the degradation behavior of Pt/C catalysts under simulated automotive conditions. By using the “tool box” synthesis method the Pt loading has been changed from low to high Pt loadings, therefore permitting to study the role of Pt on the degradation of high surface area (H...

  7. Pt/C Fuel Cell Catalyst Degradation

    DEFF Research Database (Denmark)

    Zana, Alessandro

    This thesis investigates the degradation behavior of Pt/C catalysts under simulated automotive conditions. By using the “tool box” synthesis method the Pt loading has been changed from low to high Pt loadings, therefore permitting to study the role of Pt on the degradation of high surface area (H...

  8. High growth rate of benign thyroid nodules bearing RET/PTC rearrangements.

    Science.gov (United States)

    Sapio, Maria Rosaria; Guerra, Anna; Marotta, Vincenzo; Campanile, Elisabetta; Formisano, Raffaele; Deandrea, Maurilio; Motta, Manuela; Limone, Paolo Piero; Fenzi, Gianfranco; Rossi, Guido; Vitale, Mario

    2011-06-01

    Benign thyroid nodules display a broad range of behaviors from a stationary size to a progressive growth. The RET/PTC oncogene has been documented in a fraction of benign thyroid nodules, besides papillary thyroid carcinomas, and it might therefore influence their growth. The aim of the present work was to evaluate whether RET/PTC in benign thyroid nodules associates with a different nodular growth rate. In this prospective multicentric study, 125 subjects with benign nodules were included. RET rearrangements were analyzed in cytology samples; clinical and ultrasonographic nodule characteristics were assessed at the start and at the end of the study. RET/PTC was present in 19 nodules. The difference between the mean baseline nodular volume of the RET/PTC- and RET/PTC+ nodules was not significant. After 36 months of follow-up, the RET/PTC+ group (n = 16) reached a volume higher than the RET/PTC- group (n = 90) (5.04 ± 2.67 vs. 3.04 ± 2.26 ml; P = 0.0028). We calculated the monthly change of nodule volumes as a percentage of baseline. After a mean follow-up of 36.6 months, the monthly volume increase of nodules bearing a RET rearrangement was 4.3-fold that of nodules with wild-type RET (1.83 ± 1.2 vs. 0.43 ± 1.0% of baseline volume; P < 0.0001). Benign thyroid nodules bearing RET rearrangements grow more rapidly than those with wild-type RET. Searching for RET rearrangements in benign thyroid nodules might be useful to the clinician in choosing the more appropriate and timely therapeutic option.

  9. Coaxial Electric Heaters

    Science.gov (United States)

    Strekalov, Dmitry; Matsko, Andrey; Savchenkov, Anatoliy; Maleki, Lute

    2008-01-01

    Coaxial electric heaters have been conceived for use in highly sensitive instruments in which there are requirements for compact heaters but stray magnetic fields associated with heater electric currents would adversely affect operation. Such instruments include atomic clocks and magnetometers that utilize heated atomic-sample cells, wherein stray magnetic fields at picotesla levels could introduce systematic errors into instrument readings. A coaxial electric heater is essentially an axisymmetric coaxial cable, the outer conductor of which is deliberately made highly electrically resistive so that it can serve as a heating element. As in the cases of other axisymmetric coaxial cables, the equal magnitude electric currents flowing in opposite directions along the inner and outer conductors give rise to zero net magnetic field outside the outer conductor. Hence, a coaxial electric heater can be placed near an atomic-sample cell or other sensitive device. A coaxial electric heater can be fabricated from an insulated copper wire, the copper core of which serves as the inner conductor. For example, in one approach, the insulated wire is dipped in a colloidal graphite emulsion, then the emulsion-coated wire is dried to form a thin, uniform, highly electrically resistive film that serves as the outer conductor. Then the film is coated with a protective layer of high-temperature epoxy except at the end to be electrically connected to the power supply. Next, the insulation is stripped from the wire at that end. Finally, electrical leads from the heater power supply are attached to the exposed portions of the wire and the resistive film. The resistance of the graphite film can be tailored via its thickness. Alternatively, the film can be made from an electrically conductive paint, other than a colloidal graphite emulsion, chosen to impart the desired resistance. Yet another alternative is to tailor the resistance of a graphite film by exploiting the fact that its resistance

  10. Quantitative shear wave elastography as a prognostic implication of papillary thyroid carcinoma (PTC): elasticity index can predict extrathyroidal extension (ETE).

    Science.gov (United States)

    Park, Yun Joo; Kim, Jeong-Ah; Son, Eun Ju; Youk, Ji Hyun; Park, Cheong Soo

    2013-08-01

    To investigate whether the quantitative elasticity index of shear wave elastography (SWE) can predict extrathyroidal extension (ETE) of papillary thyroid carcinoma (PTC) preoperatively. A total of 208 patients with pathology confirmed PTC whom underwent SWE during preoperative staging US between April 2011 to June 2012 were included.SWE indices of E mean, E max, E min of the index malignancy, the ratios between E mean of the lesion and parenchyma (E ratio-P), and muscle (E ratio-M), and grayscale US findings, including ETE, multifocality, bilaterality, and central and lateral lymph node (LN) metastasis were evaluated. The correlations of SWE indices and grayscale US findings with pathologic prognostic factors of PTC were analyzed by Chi square or Fisher's exact test, and multivariate regression analysis. ETE was associated with E mean, E max, E min, and E ratio-M (P = 0.005, 0.009, 0.016 and PTC.

  11. Permission to contact (PTC)--a strategy to enhance patient engagement in translational research.

    Science.gov (United States)

    Cheah, Stefanie; O'Donoghue, Sheila; Daudt, Helena; Dee, Simon; LeBlanc, Jodi; Braun, Lauren; Barnes, Rebecca; Vercauteren, Suzanne; Boone, Robert H; Watson, Peter H

    2013-08-01

    Improving patient recruitment and consent to participate in clinical studies is an important issue. The process of consent involves three steps: patient referral for contact, the preliminary interview to determine patient interest, and the informed consent discussion. We hypothesized that putting the first step of the consent process into a 'Permission to Contact' (PTC) platform would improve patient engagement, would improve the efficiency of the other steps of the process, and would be acceptable to diverse patient groups. To test this hypothesis, four PTC platforms were established in three types of outpatient health clinics (cancer, cardiac, maternal health) in different British Columbia health centers. Each began as a research project where clinic personnel were engaged, clinic flow processes were mapped, and a design for each PTC was derived by consensus. All patients at these clinics were asked for 'permission to be contacted for future research purposes.' Patient approach and permission response rates were assessed and operational costs were estimated. Overall permission rates were high for all projects, but ranged from 94% of 'cancer' patients to 80% of 'congenital heart' patients who were approached (pPTC platform is a feasible mechanism to engage patients in research programs such as biobanking. It is well supported by clinic staff and receives high engagement and acceptance from patients. Patient-approach rates vary in different clinics, likely due to both clinic and PTC process factors, but this strategy provides an efficient means of engaging patients in research and sets the stage for enhanced enrollment into translational research programs.

  12. Mediation as Problem-Solving Scene in the Light of PTC

    Directory of Open Access Journals (Sweden)

    Viktor Németh

    2014-05-01

    Full Text Available Mediation does not only mean a specific procedure or protocol but the related attitude, mindset as well. This perspective gives opportunity to demonstrate the problem in a different way than previously. In the present study, the Participatory Theory of Communication (PTC appears as a framework which makes the communication of participants of the mediation interpretable and transparent.

  13. 49 CFR 236.1015 - PTC Safety Plan content requirements and PTC System Certification.

    Science.gov (United States)

    2010-10-01

    ... vendor or supplier to be addressed during the life-cycle of the PTC system, including maximum threshold...) A description of the safety assurance concepts that are to be used for system development, including... System Certification. 236.1015 Section 236.1015 Transportation Other Regulations Relating to...

  14. Saving cost in solar water heaters by means of integration of the solar equipment in an existing hot water circulation loop; Kosteneinsparungen bei solaren Warmwasseranlagen durch Einbindung in die Warmwasserzirkulation. Vorstudie

    Energy Technology Data Exchange (ETDEWEB)

    Sitzmann, B.

    2001-07-01

    The implementation of solar water heaters in hot-water circulations for apartment buildings was examined. Models as well as investigations at 6 water supply systems in existing buildings show technically and economically opportunities for the proposed installation. Beside a reduction of the solar-piping length the proposed system shows higher opportunities for using existing hot water storage devices for solar energy storage. This is because of the energy transfer at the hot water storage devices from the existing in- and outlets instead of a heat exchanger. Today the proposed installation can be already classified as economic useful if the investment for piping and additional hot water storage device can be reduced in comparison to conventional solar water heaters. Further optimisation can be seen in the simple installation of the solar water heater to improve the economic efficiency of the proposed system. (author)

  15. Compact instantaneous water heater

    Energy Technology Data Exchange (ETDEWEB)

    Azevedo, Jorge G.W.; Machado, Antonio R.; Ferraz, Andre D.; Rocha, Ivan C.C. da; Konishi, Ricardo [Companhia de Gas de Santa Catarina (SCGAS), Florianopolis, SC (Brazil); Lehmkuhl, Willian A.; Francisco Jr, Roberto W.; Hatanaka, Ricardo L.; Pereira, Fernando M.; Oliveira, Amir A.M. [Universidade Federal de Santa Catarina (UFSC), Florianopolis, SC (Brazil)

    2012-07-01

    This paper presents an experimental study of combustion in an inert porous medium in a liquid heating device application. This project aims to increase efficiency in the application of natural gas in residential and commercial sectors with the use of advanced combustion and heat transfer. The goal is to facilitate the development of a high performance compact water heater allowing hot water supply for up to two simultaneous showers. The experiment consists in a cylindrical porous burner with an integrated annular water heat exchanger. The reactants were injected radially into the burner and the flame stabilizes within the porous matrix. The water circulates in a coiled pipe positioned at the center of the burner. This configuration allows for heat transfer by conduction and radiation from the solid matrix to the heat exchanger. This article presented preliminary experimental results of a new water heater based on an annular porous burner. The range of equivalence ratios tested varied from 0.65 to 0.8. The power range was varied from 3 to 5 kW. Increasing the equivalence ratio or decreasing the total power input of the burner resulted in increased thermal efficiencies of the water heater. Thermal efficiencies varying from 60 to 92% were obtained. The condition for the goal of a comfortable bath was 20 deg C for 8-12 L/min. This preliminary prototype has achieved water temperature of 11deg C for 5 L/min. Further optimizations will be necessary in order to achieve intense heating with high thermal efficiency. (author)

  16. Ihog and Boi elicit Hh signaling via Ptc but do not aid Ptc in sequestering the Hh ligand.

    Science.gov (United States)

    Camp, Darius; Haitian He, Billy; Li, Sally; Althaus, Irene W; Holtz, Alexander M; Allen, Benjamin L; Charron, Frédéric; van Meyel, Donald J

    2014-10-01

    Hedgehog (Hh) proteins are secreted molecules essential for tissue development in vertebrates and invertebrates. Hh reception via the 12-pass transmembrane protein Patched (Ptc) elicits intracellular signaling through Smoothened (Smo). Hh binding to Ptc is also proposed to sequester the ligand, limiting its spatial range of activity. In Drosophila, Interference hedgehog (Ihog) and Brother of ihog (Boi) are two conserved and redundant transmembrane proteins that are essential for Hh pathway activation. How Ihog and Boi activate signaling in response to Hh remains unknown; each can bind both Hh and Ptc and so it has been proposed that they are essential for both Hh reception and sequestration. Using genetic epistasis we established here that Ihog and Boi, and their orthologs in mice, act upstream or at the level of Ptc to allow Hh signal transduction. In the Drosophila developing wing model we found that it is through Hh pathway activation that Ihog and Boi maintain the boundary between the anterior and posterior compartments. We dissociated the contributions of Ptc from those of Ihog/Boi and, surprisingly, found that cells expressing Ptc can retain and sequester the Hh ligand without Ihog and Boi, but that Ihog and Boi cannot do so without Ptc. Together, these results reinforce the central role for Ptc in Hh binding in vivo and demonstrate that, although Ihog and Boi are dispensable for Hh sequestration, they are essential for pathway activation because they allow Hh to inhibit Ptc and thereby relieve its repression of Smo.

  17. Design and Implementation of the MSL Cruise Propulsion Tank Heaters

    Science.gov (United States)

    Krylo, Robert; Mikhaylov, Rebecca; Cucullu, Gordon; Watkins, Brenda

    2008-01-01

    This slide presentation reviews the design and the implementation of the heaters for the Mars Science Laboratory (MSL). The pressurized tanks store hydrazine that freezes at 2 C, this means that heaters are required to keep the hydrazine and the helium at 36 C for the trip to Mars. Using the TMG software the heat loss was analyzed, and a thermal model simulates a half full tank which yielded a 13W heating requirement for each hemisphere. Views of the design, and the heater are included.

  18. Concomitant BRAF(V600E) mutation and RET/PTC rearrangement is a frequent occurrence in papillary thyroid carcinoma.

    Science.gov (United States)

    Guerra, Anna; Zeppa, Pio; Bifulco, Maurizio; Vitale, Mario

    2014-02-01

    The tyrosine kinase receptors/RAS/RAF/MAPK cascade is a site of mutational events associated with thyroid carcinogenesis. Some studies suggest the reciprocal exclusion of different oncogenes in the mitogen-activated protein kinase cascade, whereas others suggest that BRAF mutations and RET rearrangements can simultaneously occur in sporadic cases. The aim of this study was to determine the prevalence of concomitant BRAF(V600E) mutation and RET/PTC rearrangements in the same tumor and its association with some clinicopathological features. The percentage of mutant BRAF alleles and the presence of RET/PTC rearrangements were determined by means of pyrosequencing and Southern blot analysis of reverse transcription polymerase chain reaction products in a series of 72 conventional papillary thyroid carcinomas (PTCs). Then, the associations between clinicopathological characteristics and mutation status were assessed. BRAF(V600E) alleles were present in 32 out of 72 PTCs (44.4%) in the range of 5.1-44.7% of total BRAF alleles. RET/PTC was present in 26 tumors (36.1%). Concomitant subclonal BRAF and RET/PTC were demonstrated in 14 PTCs (19.4%), and none of the oncogenes was detected in 22 tumors (30.5%). Only BRAF(V600E) was associated with a more advanced tumor staging. The present study demonstrates that concomitant BRAF mutation and RET/PTC rearrangement is a frequent event in PTC.

  19. Subsurface heaters with low sulfidation rates

    Energy Technology Data Exchange (ETDEWEB)

    John, Randy Carl; Vinegar, Harold J

    2013-12-10

    A system for heating a hydrocarbon containing formation includes a heater having an elongated ferromagnetic metal heater section. The heater is located in an opening in a formation. The heater section is configured to heat the hydrocarbon containing formation. The exposed ferromagnetic metal has a sulfidation rate that goes down with increasing temperature of the heater, when the heater is in a selected temperature range.

  20. Threshold distributions of phenylthiocarbamide (PTC) in the Chinese population.

    Science.gov (United States)

    Guo, S W; Shen, F M; Wang, Y D; Zheng, C J

    1998-11-30

    The ability to taste phenylthiocarbamide (PTC) is a well-documented Mendelian trait. Mapping and cloning the gene(s) responsible for the PTC tasting ability would help to delineate the molecular basis for the variations in PTC tasting ability in humans and to shed new light on taste chemosensory functions. In view of the spectacular successes in genome science, the positional cloning strategy seems to be a feasible approach to the isolation of the gene(s) underlying the PTC tasting ability. As a first step toward mapping the gene(s), we collected PTC taste threshold data on 106 individuals, most of them being university students, in Shanghai, China. Using various parametric and nonparametric statistical methods, we have found that the data set is best described by a bimodal distribution. The frequency of PTC nontasters is estimated to be 10%. This is consistent with the view that the PTC nontasting ability follows a recessive mode of inheritance. Several authors had previously reported PTC data on Chinese living outside China. Our data are, to our knowledge, the first ever collected from the Chinese population within China.

  1. Water heaters subject to new regulations.

    Science.gov (United States)

    Clarke, Alan

    2014-06-01

    On 26 September 2015 the Ecodesign and Energy Labelling Directives for water heaters (Lot 2) come into force, meaning that water-heating products sold in the UK and other countries in the European Economic Area will need to meet minimum energy performance criteria in order to be legally placed on the market, and will require an energy label. Here Alan Clarke, technical support manager at Heatrae Sadia, explains more.

  2. High-Throughput Screening for Readthrough Modulators of CFTR PTC Mutations.

    Science.gov (United States)

    Liang, Feng; Shang, Haibo; Jordan, Nikole J; Wong, Eric; Mercadante, Dayna; Saltz, Josef; Mahiou, Jerome; Bihler, Hermann J; Mense, Martin

    2017-02-01

    Cystic fibrosis (CF) is a hereditary disease caused by mutations in the gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR). A large number of nearly 2000 reported mutations, including the premature termination codon (PTC) mutations, urgently require new and personalized medicines. We have developed cell-based assays for readthrough modulators of CFTR PTC mutations (or nonsense mutation suppressors), based on the trafficking and surface expression of CFTR. Approximately 85,000 compounds have been screened for two PTC mutations (Y122X and W1282X). The hit rates at the threshold of 50% greater than vehicle response are 2% and 1.4% for CFTR Y122X and CFTR W1282X, respectively. The overlap of the two hit sets at this stringent hit threshold is relatively small. Only ~28% of the hits from the W1282X screen were also hits in the Y122X screen. The overlap increases to ~50% if compounds are included that in the second screen achieve only a less stringent hit criterion, that is, horseradish peroxidase (HRP) activity greater than three standard deviations above the mean of the vehicle. Our data suggest that personalization may not need to address individual genotypes, but that patients with different CFTR PTC mutations could benefit from the same medicines.

  3. PTC bitter taste genetic polymorphism, food choices, physical growth in body height and body fat related traits among adolescent girls from Kangra Valley, Himachal Pradesh (India).

    Science.gov (United States)

    Sharma, Krishan; Kaur, Goga Kirandeep

    2014-01-01

    Bitter sensitivity among individuals and ethnic groups is partly due to polymorphic bitter taste receptor genes (TAS2Rs). PTC/PROP bitter taste responsiveness at locus TAS2R38 is a well-established index of individual variation in oral sensation that has been linked with predicting food liking and consumption. Previous studies suggest that the relationship between PTC/PROP and anthropometric traits remains controversial. To explore the role of TAS2R38 locus in taste choices, adolescent growth trend for body height, weight and fat patterning among girls and to evaluate their growth status. Cross-sectional data on 210 girls ranging in age from 11-18 years were collected from Palampur in the Kangra valley of Himachal Pradesh. The proportion of PTC non-tasters was 19.52%. PTC tasters and non-tasters had some differences in their food choices and preferences. More sensitive PTC tasters had a low preference for raw cruciferous vegetables and bitter tasting foods (like bitter gourd) and beverages, while they had higher preference for sweet-tasting foods (p < 0.05). PTC tasters overtook their PTC non-taster counterparts from age 14 through 16 years in having higher mean average skinfold, percentage body fat, fat mass index and fat-free mass index. PTC non-tasters had higher mean stature than tasters through all age groups. PTC tasters had slightly higher mean body weight than tasters at age 11, but in later years the advantage was lost; the total gain among non-tasters through adolescence was higher (78.20%) than tasters (66.92%). PTC thresholds significantly and negatively correlated with body height. TAS2R38 locus seems to have a role in food tastes, choices and preferences. Perceived bitterness of PTC/PROP thresholds were significantly and negatively correlated with body height and fat-free mass. These results, thus, tentatively suggest that the PTC non-taster gene may help in better absorption of calcium than its counter taster allele. Studies on differences in

  4. 46 CFR 119.320 - Water heaters.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Water heaters. 119.320 Section 119.320 Shipping COAST... Machinery § 119.320 Water heaters. (a) A water heater must meet the requirements of Parts 53 and 63 in... electric water heater is also acceptable if it: (1) Has a capacity of not more than 454 liters (120...

  5. 46 CFR 182.320 - Water heaters.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Water heaters. 182.320 Section 182.320 Shipping COAST...) MACHINERY INSTALLATION Auxiliary Machinery § 182.320 Water heaters. (a) A water heater must meet the...), except that an electric water heater is also acceptable if it: (1) Has a capacity of not more than...

  6. Thermal behavior of a porous electric heater

    Energy Technology Data Exchange (ETDEWEB)

    Naji, M.; Al-Nimr, M.A. [Jordan University of Science and Technology, Irbid (Jordan). Dept. of Mechanical Engineering

    2002-03-01

    The performance of a proposed porous electric heater is investigated. The porous heater exchanges heat with the working fluid through its large volumetric surface area. As a result, it produces lower surface temperature as compared with the conventional heater for the same imposed heating power. Two mathematical models are presented to describe the thermal behavior of both heaters. Axial diffusion is included in the governing equation of the solid conventional heater. The predictions of both models are compared at different operating conditions where it is found that porous heaters have much better thermal performance than the conventional heaters. (author)

  7. ENERGY STAR Certified Water Heaters

    Data.gov (United States)

    U.S. Environmental Protection Agency — Certified models meet all ENERGY STAR requirements as listed in the Version 3.0 ENERGY STAR Program Requirements for Water Heaters that are effective April 16, 2015....

  8. Heater head for stirling engine

    Science.gov (United States)

    Corey, John A.

    1985-07-09

    A monolithic heater head assembly which augments cast fins with ceramic inserts which narrow the flow of combustion gas and obtains high thermal effectiveness with the assembly including an improved flange design which gives greater durability and reduced conduction loss.

  9. High rate of BRAF and RET/PTC dual mutations associated with recurrent papillary thyroid carcinoma.

    Science.gov (United States)

    Henderson, Ying C; Shellenberger, Thomas D; Williams, Michelle D; El-Naggar, Adel K; Fredrick, Mitchell J; Cieply, Kathleen M; Clayman, Gary L

    2009-01-15

    Papillary thyroid carcinoma (PTC), the most common thyroid malignancy, usually possesses BRAF mutation or rearranged in translation (RET)/PTC rearrangements. PTC usually possesses BRAF mutation or RET/PTC rearrangements. The mutation status of patients with recurrent PTC has never been characterized in a large population. Mutation status was determined in a cohort of 54 patients with recurrent PTC and analyzed for clinicopathologic relationships. BRAF and ras mutations were determined by PCR and sequencing of genomic DNA. RET/PTC rearrangements were analyzed by reverse transcription-PCR. BRAF mutation in exon 15 (V600E) was found in 42/54 (77.8%) recurrent PTC patients. The RET/PTC rearrangements were detected in 9 of 54 (16.7%) patients. In addition, 5 of 54 (9.3%) recurrent PTC patients had both a BRAF mutation and a RET/PTC rearrangement. The prevalence of tumors with dual mutations found in the recurrent population far exceeds the frequency historically reported for patients with primary PTC. Patients with dual mutations were significantly older (80% older than 45 years) than patients with a BRAF mutation alone (38% older than 45 years). Recurrent PTC is significantly associated with a predominant BRAF mutation. RET/PTC rearrangements, although commonly associated with primary PTCs in younger patients, are uncommonly found in recurrent PTC patients. In addition, the incidence of dual mutations was higher in patients with recurrent PTC than in those primary PTC, as reported by others.

  10. Overexpression of wild-type c-RET and zero prevalence of RET/PTC rearrangements are associated with papillary thyroid cancer (PTC) in Kuwait.

    Science.gov (United States)

    El-Abdallah, Abir A; Junaid, Thamradeen A

    2011-02-01

    Papillary thyroid carcinoma (PTC) is common in Kuwait. The activation of the RET oncogene by DNA rearrangement (RET/PTC) is known to have an important role in PTC carcinogenesis. However, the real frequency of the RET/PTC expression in PTC is variable between different studies. This study seeks to determine the prevalence of RET/PTC and to analyze the RET oncogene expression associated with PTC in Kuwait. RET expression and DNA rearrangements (RET/PTC 1, RET/PTC 2 and RET/PTC 3) were studied by RT-PCR in different thyroid diseases. Results were confirmed by the Southern blot and by immunohistochemistry. Quantitative real-time PCR was used to determine the level of RET mRNA expression in PTCs. Wild-type (nonrearranged) c-RET oncogene was overexpressed in 60% of PTC cases and absent in follicular thyroid carcinoma (FTC), anaplastic thyroid carcinoma (ATC), follicular adenomas (FA) or normal thyroid. No RET/PTC rearrangement was detected in any sample. The c-RET expression in Hashimoto's thyroiditis and multinodular goiter was limited to follicular cells with PTC-like nuclear changes. The overexpression of wild-type c-RET is a characteristic molecular event of PTCs in Kuwait. The prevalence of RET/PTC is zero and among the lowest recorded in the world. Copyright © 2010 Elsevier Inc. All rights reserved.

  11. Solar Hot Water Heater

    Science.gov (United States)

    1978-01-01

    The solar panels pictured below, mounted on a Moscow, Idaho home, are part of a domestic hot water heating system capable of providing up to 100 percent of home or small business hot water needs. Produced by Lennox Industries Inc., Marshalltown, Iowa, the panels are commercial versions of a collector co-developed by NASA. In an effort to conserve energy, NASA has installed solar collectors at a number of its own facilities and is conducting research to develop the most efficient systems. Lewis Research Center teamed with Honeywell Inc., Minneapolis, Minnesota to develop the flat plate collector shown. Key to the collector's efficiency is black chrome coating on the plate developed for use on spacecraft solar cells, the coating prevents sun heat from "reradiating," or escaping outward. The design proved the most effective heat absorber among 23 different types of collectors evaluated in a Lewis test program. The Lennox solar domestic hot water heating system has three main components: the array of collectors, a "solar module" (blue unit pictured) and a conventional water heater. A fluid-ethylene glycol and water-is circulated through the collectors to absorb solar heat. The fluid is then piped to a double-walled jacket around a water tank within the solar module.

  12. Molecular characteristics of papillary thyroid carcinomas without BRAF mutation or RET/PTC rearrangement: relationship with clinico-pathological features.

    Science.gov (United States)

    Durand, Stéphanie; Ferraro-Peyret, Carole; Joufre, Mireille; Chave, Annie; Borson-Chazot, Françoise; Selmi-Ruby, Samia; Rousset, Bernard

    2009-06-01

    About 60-70% of papillary thyroid carcinomas (PTC) present a BRAF(T1799A) gene mutation or a rearrangement of RET gene (RET/PTC). In this study, we examined whether PTC without BRAF(T1799A) mutation and without RET/PTC rearrangement named PTC-ga(-) were distinguishable from PTC-ga(+) (with one or the other gene alteration) on the basis of gene expression characteristics. We analyzed the mutational state of 116 PTC and we compared gene expression profiles of PTC-ga(+) and PTC-ga(-) from data of a 200 gene macroarray and quantitative PCR. Seventy five PTC were PTC-ga(+) and 41 were PTC-ga(-). Unsupervised analyses of macroarray data by hierarchical clustering led to a complete segregation of PTC-ga(+) and PTC-ga(-). In a series of 42 genes previously recognized as PTC 'marker' genes, 22 were found to be expressed at a comparable level in PTC-ga(-) and normal tissue. Thyroid-specific genes, TPO, TG, DIO1, and DIO2 were under-expressed in PTC-ga(+) but expressed at a normal level in PTC-ga(-). A few genes including DUOX1 and DUOX2 were selectively dys-regulated in PTC-ga(-). Tumor grade of PTC-ga(-) was lower than that of PTC-ga(+). There was a strong association between the mutational state and histiotype of PTC; 81% of PTC follicular variants were corresponded to PTC-ga(-), whereas 84% of PTC of classical form were PTC-ga(+). In conclusion, we show that PTC without BRAF(T1799A) mutation or RET/PTC rearrangement, mainly corresponding to follicular variants, maintain a thyroid differentiation expression level close to that of normal tissue and should be of better prognosis than PTC with one or the other gene alteration.

  13. Chronic ataluren (PTC124) treatment of nonsense mutation cystic fibrosis.

    Science.gov (United States)

    Wilschanski, M; Miller, L L; Shoseyov, D; Blau, H; Rivlin, J; Aviram, M; Cohen, M; Armoni, S; Yaakov, Y; Pugatsch, T; Pugatch, T; Cohen-Cymberknoh, M; Miller, N L; Reha, A; Northcutt, V J; Hirawat, S; Donnelly, K; Elfring, G L; Ajayi, T; Kerem, E

    2011-07-01

    In a subset of patients with cystic fibrosis (CF), nonsense mutations (premature stop codons) disrupt production of full-length, functional CF transmembrane conductance regulator (CFTR). Ataluren (PTC124) allows ribosomal readthrough of premature stop codons in mRNA. We evaluated drug activity and safety in patients with nonsense mutation CF who took ataluren three times daily (morning, midday and evening) for 12 weeks at either a lower dose (4, 4 and 8 mg·kg(-1)) or higher dose (10, 10 and 20 mg·kg(-1)). The study enrolled 19 patients (10 males and nine females aged 19-57 yrs; dose: lower 12, higher seven) with a classic CF phenotype, at least one CFTR nonsense mutation allele, and an abnormal nasal total chloride transport. Both ataluren doses were similarly active, improving total chloride transport with a combined mean change of -5.4 mV (pataluren administration produced time-dependent improvements in CFTR activity and clinical parameters with generally good tolerability.

  14. Assessment of RET/PTC1 and RET/PTC3 rearrangements in fine-needle aspiration biopsy specimens collected from patients with Hashimoto's thyroiditis

    Directory of Open Access Journals (Sweden)

    Cyniak-Magierska Anna

    2011-01-01

    Full Text Available Abstract Background RET/PTC rearrangements are the most frequent molecular changes in papillary thyroid carcinoma (PTC. So far, 15 main RET/PTC rearrangements have been described, among which RET/PTC1 and RET/PTC3 are the most common in PTC - especially in radiation-induced tumours. RET/PTC1 and RET/PTC3 are the result of intrachromosomal paracentric inversions in chromosome 10, where RET and the activating genes (H4 and ELE1, respectively are located. Recently, RET/PTC rearrangements have been shown not only in PTC but also in benign thyroid lesions, including Hashimoto's thyroiditis (HT. The aim of study was an assessment of RET/PTC1 and RET/PTC3 rearrangements in patients with Hashimoto's thyroiditis. Materials and methods Thyroid aspirates, eligible for the study, were obtained from 26 patients with Hashimoto's thyroiditis by fine-needle aspiration biopsy (FNAB. Each aspirate was smeared for conventional cytology, while its remaining part was immediately washed out of the needle. The cells, obtained from the needle, were used in further investigation. Total RNA from FNAB was extracted by use of an RNeasy Micro Kit, based on modified Chomczynski and Sacchi's method and reverse transcription (RT-PCR was done. Quantitative evaluation of RET/PTC1 and RET/PTC3 rearrangements by real-time PCR was performed by an ABI PRISM® 7500 Sequence Detection System. In the study, PTC tissues with known RET/PTC1 and RET/PTC3 rearrangements served as a reference standard (calibrator, while β-actin gene was used as endogenous control. Results Amplification reactions were done in triplicate for each examined sample. No RET/PTC1 and RET/PTC3 rearrangements were found in the examined samples. Conclusions Our results indicate that RET/PTC1 and RET/PTC3 rearrangements in Hashimoto's thyroiditis, if any, are rather rare events and further investigations should be conducted in order to determine molecular changes, connecting Hashimoto's thyroiditis with PTC.

  15. Navigating the management of follicular variant papillary thyroid carcinoma subtypes: a classic PTC comparison.

    Science.gov (United States)

    Finnerty, Brendan M; Kleiman, David A; Scognamiglio, Theresa; Aronova, Anna; Beninato, Toni; Fahey, Thomas J; Zarnegar, Rasa

    2015-04-01

    There are three subtypes of follicular variant papillary thyroid carcinoma (fvPTC): completely encapsulated, well circumscribed, and infiltrative. While infiltrative tumors are more aggressive than completely encapsulated, controversy exists regarding management of fvPTC subtypes. We compared the clinicopathologic features of fvPTC subtypes to those of classic PTC (cPTC) to help guide fvPTC management, using cPTC as a reference. A retrospective review was performed on 316 patients with PTC treated at a single institution from 2004 to 2011. There were 197 cPTC and 119 fvPTC tumors, including completely encapsulated (n = 46), well circumscribed (n = 46), and infiltrative (n = 27). Clinicopathologic data were compared between groups. fvPTC patients had larger tumors than cPTC patients (1.6 cm vs. 1.2 cm, p = 0.001), but age, sex, and family history did not differ. Thirty-one percent of cPTC tumors had extrathyroidal extension compared to 0 % of completely encapsulated, 0 % of well-circumscribed, and 52 % of infiltrative fvPTC tumors (p management algorithm for fvPTC.

  16. Water inflow into boreholes during the Stripa heater experiments

    Energy Technology Data Exchange (ETDEWEB)

    Nelson, P.H.; Rachiele, R.; Remer, J.S.; Carlsson, H.

    1981-04-01

    During the operation of three in-situ heater experiments at Stripa, Sweden, groundwater flowed into many of the instrumentation and heater boreholes. These flows were recovered and measured routinely. The records of water inflow indicate two origins: inflow attributed to local hydrological pressure gradients, and water migration from cracks closing under the rapidly increasing, thermal-induced stress changes. The latter component appeared as a main pulse that occurred when the heaters were turned on, and lasted about 30 to 40 days, steadily declining over the next several months, and decreasing sharply when heater power was decreased or stopped. The magnitude of the total inflow per hole ranged over more than five decades, from 0.1 to over 10,000 liters over the 500 to 600 day time periods. When plotted against the logarithm of total volume, the frequency distribution displays a normal curve dependence with a mean of approximately 10 liters. Of this amount, 1 to 2 liters of flow into 38-mm-diam boreholes accompanied an increase in applied heat load. These amounts are compatible with rock porosities of a fraction of one percent. Inflow into the 3.6 and 5.0 kW heater holes peaked within 3 to 6 days after heater turn on, then declined to zero inflow, with no further inflow measured for the remainder of the experiments. In the heater holes of the time-scaled experiment, which operated at 1.125 kW or less, the initial pulse of inflow took much longer to decay, and 7 of 8 heater holes continued to flow throughout the experiment. The packing off and isolation of a borehole some 40 m distant in the ventilation drift dramatically increased the inflow into the heater holes in one of the three heater experiments. This demonstrated the existence of permeable flow paths among a number of boreholes. The records of water inflow demonstrate the need for a thorough understanding of the nature of fluid flow and storage in fractured crystalline rock.

  17. CFD Study of Fluid Flow in an All-glass Evacuated Tube Solar Water Heater

    DEFF Research Database (Denmark)

    Ai, Ning; Fan, Jianhua; Li, Yumin

    2008-01-01

    Abstract: The all-glass evacuated tube solar water heater is one of the most widely used solar thermal technologies. The aim of the paper is to investigate fluid flow in the solar water heater by means of computational fluid dynamics (CFD). The investigation was carried out with a focus...

  18. Quench Heater Studies for the LHC Magnets

    CERN Document Server

    Rodríguez-Mateos, F

    2001-01-01

    About 2000 LHC (CERN's Large Hadron Collider) superconducting magnets will be protected with quench heaters against development of excessive voltage and overheating after a resistive transition. The quench heater strips are powered by capacitor bank discharge power supplies. The strips are made of stainless steel partially plated with copper to reduce their resistance and to allow for the connection of quench heaters in series. The strips are embedded in between two polyimide foils. The initial power density and the current decay time determine the quench heater effectiveness. Since only one type of heater power supply will be available, the copper plating cycle is adapted for the various magnet types to keep the resistance of the heater circuit constant. Different quench heater designs have been tested on various prototype magnets to optimise the copper-plating cycle and the electric insulation of the heater strip. This paper summarises the experimental results and computations that allowed to finalise the h...

  19. Shared savings gets realtor new water heaters

    Energy Technology Data Exchange (ETDEWEB)

    Mullin, R.

    1983-08-08

    The Grenadier Realty Co. of New York is financing four energy-efficient water heaters for apartment buildings with a shared savings arrangement. The arrangement allows Grenadier to avoid front-end costs, which were paid by Independent Water Heaters Inc. in exchange for a decreasing share of the savings. Grenadier will own the heaters when the five-year contract expires. By allowing a shutdown of boilers during the summer months, the heaters will further increase energy savings. (DCK)

  20. The performance of porous electric heaters

    Energy Technology Data Exchange (ETDEWEB)

    Al-Nimr, M.A.; Naji, M.

    2003-03-01

    The performance of a proposed porous electric heater is investigated. The porous heater exchanges heat with the working fluid through its large volumetric surface area. As a result, it produces lower surface temperature as compared with the conventional heater for the same imposed heating power. Two mathematical models are presented to describe the thermal behavior of both heaters and the predictions of both models are compared at different operating conditions. (author)

  1. 14 CFR 27.833 - Heaters.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Heaters. 27.833 Section 27.833 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS... Heaters. Each combustion heater must be approved. Fire Protection ...

  2. 14 CFR 29.833 - Heaters.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Heaters. 29.833 Section 29.833 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS... Heaters. Each combustion heater must be approved. Fire Protection ...

  3. MAD-X/PTC lattice design for DAPHNE at Frascati

    CERN Document Server

    Forest, Etienne; Schmidt, Frank

    2006-01-01

    In absence of a program that takes as an input the desired or known location of the magnets in the tunnel, accelerator designers have been using MAD that looks at a ring as a sequence of magnets without a connection to the tunnel. In many simple examples that is just fine, but once more complicated structures are treated one is bound to play tricks with MAD. Here PTC comes to the rescue. It is shown how pieces of this machine that exist in MADX format are used in PTC to create this double ring, as found on the accelerator floor, with a proper survey in the forward and backward direction. Special elements have been implemented in MAD-X to allow the full PTC description of the machine.

  4. Solar water heater design package

    Science.gov (United States)

    1981-01-01

    Package describes commercial domestic-hot-water heater with roof or rack mounted solar collectors. System is adjustable to pre-existing gas or electric hot-water house units. Design package includes drawings, description of automatic control logic, evaluation measurements, possible design variations, list of materials and installation tools, and trouble-shooting guide and manual.

  5. Application of New Electrolyte Model to Phase Transfer Catalyst (PTC) Systems

    DEFF Research Database (Denmark)

    2015-01-01

    Abstract Phase transfer catalyst (PTC) is used to transfer the desirable active form of an anion from the aqueous phase to organic phase where the reaction occurs. One of major challenges for process design of the PTC system is to establish a reliable thermodynamic model capable of describing phase...... in PTC systems, thereby, extending the application range of the PTC-system model. The solubility of PTC in organic solvents, which is a key factor for strategy of PTC and solvent selection, has been calculated using the e-NRTL-SAC model....

  6. 14 CFR 23.859 - Combustion heater fire protection.

    Science.gov (United States)

    2010-01-01

    ... passage that surrounds the combustion chamber. (b) Ventilating air ducts. Each ventilating air duct... fireproof valves or by equally effective means, the ventilating air duct downstream of each heater must be...) Combustion air ducts. Each combustion air duct must be fireproof for a distance great enough to...

  7. [RET/PTC rearrangement affects multifocal formation of papillary thyroid carcinoma].

    Science.gov (United States)

    Zhang, X; Su, X; Chen, W C; Li, Y; Yang, Z Y; Deng, W Z; Deng, T C; Yang, A K

    2017-06-07

    Objective:RET/PTC gene rearrangement can lead to aberrant activation of tyrosine kinase receptors, which is a common mutation in papillary thyroid carcinoma (PTC). This study focuses on the association of RET/PTC rearrangements with PTC clinical factors. Methods: From January 2011 to December 2013, a total of 114 patients with PTC were enrolled in this study. Clinicopathological parameters, lifestyle, and thyroid hormone levels were collected. RET/PTC rearrangements were detected by TaqMan PCR and verified by Sanger sequencing.Data were analyzed with SPSS software, including chi-square test, Fisher's exact test, Mann-Whitney U test, Student's t-test, and Logistic regression. Results:RET/PTC rearrangements were not found in all paracancerous normal thyroid tissues, and were detected in 23.68% (27/114) of PTC. Further analysis revealed no correlation between RET/PTC rearrangement and thyroid function, clinicopathologic parameters, and lifestyle in the total PTC group or in the subgroup of patients with concomitant diseases (including Hashimoto's thyroiditis and nodular goiter). But in the subgroup of PTC without concomitant disease, RET/PTC rearrangement was associated with tumor multifocal (P=0.018), and RET/PTC-positive PTC patients had an increased risk of tumor multifocal (OR=5.57, 95% CI 1.39-22.33). It was also found that RET/PTC rearrangement was associated with an abnormal increase in TSH level of one month after surgery (P= 0.037). Conclusion: Nodular goiter and Hashimoto 's thyroiditis may be a confounding factor in PTC. RET/PTC rearrangement may play an important role in the occurrence of thyroid carcinoma multifocal after exclusion of this confounding factor.

  8. SYNTHESIS OF ACRYLIC ESTERS IN PTC: KINETICS AND ECOLOGICAL ASPECTS

    Directory of Open Access Journals (Sweden)

    G.Torosyan

    2013-06-01

    Full Text Available The synthesis of esters of acrylic acids, which are applied for synthesis of polymeric materials by phase transfer catalysis were discussed (PTC, which is very useful for reduction of reaction consumption of materials and power.This method has substantial advantages including high speed of the process, soft condition of reaction and reduced pollution.

  9. Evaluation of radiofrequency dielectric heaters workers exposure.

    Science.gov (United States)

    Benes, M; Del Frate, S; Villalta, R

    2008-01-01

    Radiofrequency dielectric heaters (RFDH) are widely used in the woodworking industry for gluing laminates by applying pressure and RF heating. The workers operating such equipment remain in the vicinity of the machinery all day and can therefore be exposed to considerable levels of electric and magnetic field at RFs. This work describes the method used to measure the strength of fields generated by this particular machinery. This procedure is based on current methods cited in the literature and introduces the necessary modifications to meet this specific case. In particular, as there is often a scarcity of technical data available relating to such heaters, it is suggested that a spectrum analyser be used for measurements in the frequencies domain. On the basis of the data obtained the norms of reference are established, the instrumentation to be used in successive stages determined as well as the identification of possible sources of interference from spurious signals. Furthermore, a mapping of the field strengths is presented and the means of determining the decay curve as a function of distance. This last type of measurement is done to estimate the effectiveness of grounding the machinery. The report ends with an estimate of the exposure of workers to electromagnetic fields and also some recommendations for reducing risk.

  10. SMOKING INCLINED GROUPS ACCORDING TO THE PHENOTYPE OF THE PTC GENE.

    Science.gov (United States)

    Khukhunaishvili, R; Tskvitinidze, S; Koridze, M; Nagervadze, M; Chelidze, N

    2016-09-01

    The ability to sense phenylthiocarbamide (PTC) bitterness represents a well-known and convenient genetic marker for human populations and biomedical studies. Two basic phenotypes can be dichotomized by PTC sensitivity: PTC-sensitive or "tester" and PTC-insensitive or "non-tester". The majority of the population (approximately 70%) belong to the PTC-sensitive phenotype, while the remaining 30% are PTC-insensitive. The distribution of PTC sensitivities varies by consumption of alcohol, bitter coffee and cigarettes. This study was conducted among randomly selected 90 cigarette smokers living in the Ajara Region of Georgia. Our results indicate that PTC-insensitive phenotypes are correlated with cigarette consumption and should be considered as an important genetic proxy for cigarette use. This marker may prove very useful for identifying adolescents who might benefit from a focused smoking prevention intervention.

  11. Welding shield for coupling heaters

    Science.gov (United States)

    Menotti, James Louis

    2010-03-09

    Systems for coupling end portions of two elongated heater portions and methods of using such systems to treat a subsurface formation are described herein. A system may include a holding system configured to hold end portions of the two elongated heater portions so that the end portions are abutted together or located near each other; a shield for enclosing the end portions, and one or more inert gas inlets configured to provide at least one inert gas to flush the system with inert gas during welding of the end portions. The shield may be configured to inhibit oxidation during welding that joins the end portions together. The shield may include a hinged door that, when closed, is configured to at least partially isolate the interior of the shield from the atmosphere. The hinged door, when open, is configured to allow access to the interior of the shield.

  12. Space Station solar water heater

    Science.gov (United States)

    Horan, D. C.; Somers, Richard E.; Haynes, R. D.

    1990-01-01

    The feasibility of directly converting solar energy for crew water heating on the Space Station Freedom (SSF) and other human-tended missions such as a geosynchronous space station, lunar base, or Mars spacecraft was investigated. Computer codes were developed to model the systems, and a proof-of-concept thermal vacuum test was conducted to evaluate system performance in an environment simulating the SSF. The results indicate that a solar water heater is feasible. It could provide up to 100 percent of the design heating load without a significant configuration change to the SSF or other missions. The solar heater system requires only 15 percent of the electricity that an all-electric system on the SSF would require. This allows a reduction in the solar array or a surplus of electricity for onboard experiments.

  13. Starch gelatinization in coiled heaters.

    Science.gov (United States)

    Kelder, J D H; Ptasinski, K J; Kerkhof, P J A M

    2004-01-01

    A gelatinizing model food derived from a 5% w/w cross-linked waxy maize starch suspension was simulated in coiled heaters to assess the impact of centrifugal forces on flow and heat transfer. For four coil diameters (D = 0.25, 1, 2.5, and infinity m) and three flow rates (w = 0.5, 1, and 2 m/s), heat transfer, viscous development, and the severity of channeling were evaluated. Increasing curvature proved to suppress channeling as a result of more uniform heating and gelatinization. The maximum attainable viscosity was also higher, implying a lower starch consumption for a target viscosity. Higher flow rates necessitated longer heaters, and the maximum viscosity decreased. Moderate product velocities are therefore recommended.

  14. Experimental characteristics of vortex heaters

    Science.gov (United States)

    Piralishvili, Sh. A.; Novikov, N. N.

    The performance of a Ranque-Hilsch vortex tube is investigated experimentally for the case where the tube operates as a heater, with the mass of the heated gas remaining constant. The results obtained indicate that energy separation zones with sufficiently high (50 percent) relative heating effects can be achieved for a gas flow ratio of unity. A nomogram is presented for calculating the relative and absolute heating effects as a function of the tube geometry.

  15. Graphite/Epoxy Deicing Heater

    Science.gov (United States)

    Hung, Ching-Cheh; Dillehay, Michael E.; Stahl, Mark

    1988-01-01

    Heat applied close to surface protected. One ply of highly electrically- and thermally-conductive brominated-graphite fiber composite laminated between two plies of electrically-insulating composite material, with michel foil making contact with end portions of graphite fibers. Part of foil exposed beyond composite to serve as electrical contact. Graphite/Epoxy composite heater developed to prevent and reverse formation of ice on advanced composite surfaces of aircraft.

  16. Near-surface heater experiments

    Energy Technology Data Exchange (ETDEWEB)

    Tyler, L.D.; Cuderman, J.F.; Krumhansl, J.L.; Lappin, A.

    1978-12-31

    Full-scale near-surface heater experiments are presently being conducted by Sandia Laboratories in the Conasauga Formation at Oak Ridge, Tennessee, and in the Eleana Formation on the Nevada Test Site, Nevada. The purposes of these experiments are: (1) to determine if argillaceous media can withstand thermal loads characteristic of high level waste; (2) to provide data for improvement of themomechanical modeling of argillaceous rocks; (3) to identify instrumentation development needed for further in situ testing; and (4) to identify unexpected general types of behavior, if any. The basic instrumentation of these tests consists of a heater in a central hole, surrounded by arrays of holes containing various instrumentation. Temperatures, thermal profiles, vertical displacements, volatile pressurization, and changes in in situ stresses are measured in each experiment as a function of time, and compared with pretest modeling results. Results to date, though in general agreement with modeling results assuming conductive heat transfer within the rock, indicate that the presence of even small amounts of water can drastically affect heat transfer within the heater hole itself, and that small amounts of upward convection of water may be occurring in the higher temperature areas of the Conasauga experiments.

  17. Array CGH demonstrates characteristic aberration signatures in human papillary thyroid carcinomas governed by RET/PTC.

    Science.gov (United States)

    Unger, K; Malisch, E; Thomas, G; Braselmann, H; Walch, A; Jackl, G; Lewis, P; Lengfelder, E; Bogdanova, T; Wienberg, J; Zitzelsberger, H

    2008-07-31

    The aim of this study is to investigate additional genetic alterations in papillary thyroid carcinomas (PTCs) with known RET/PTC rearrangements. We applied array-based comparative genomic hybridization (array CGH) to 33 PTC (20 PTC from adults, 13 post-Chernobyl PTC from children) with known RET/PTC status. Principal component analysis and hierarchical cluster analysis identified cases with similar aberration patterns. Significant deviations between tumour-groups were obtained by statistical testing (Fisher's exact test in combination with Benjamini-Hochberg FDR-controlling procedure). FISH analysis on FFPE sections was applied to validate the array CGH data. Deletions were found more frequently in RET/PTC-positive and RET/PTC-negative tumours than amplifications. Specific aberration signatures were identified that discriminated between RET/PTC-positive and RET/PTC-negative cases (aberrations on chromosomes 1p, 3q, 4p, 7p, 9p/q, 10q, 12q, 13q and 21q). In addition, childhood and adult RET/PTC-positive cases differ significantly for a deletion on the distal part of chromosome 1p. There are additional alterations in RET/PTC-positive tumours, which may act as modifiers of RET activation. In contrast, alterations in RET/PTC-negative tumours indicate alternative routes of tumour development. The data presented serve as a starting point for further studies on gene expression and function of genes identified in this study.

  18. Functional rescue of REP1 following treatment with PTC124 and novel derivative PTC-414 in human choroideremia fibroblasts and the nonsense-mediated zebrafish model.

    Science.gov (United States)

    Moosajee, Mariya; Tracey-White, Dhani; Smart, Matthew; Weetall, Marla; Torriano, Simona; Kalatzis, Vasiliki; da Cruz, Lyndon; Coffey, Peter; Webster, Andrew R; Welch, Ellen

    2016-08-15

    Choroideremia (CHM) is an X-linked chorioretinal dystrophy that is caused by mutations within a single gene, CHM Currently no effective treatment exists for these patients. Since over 30% of patients harbour nonsense mutations in CHM, nonsense suppression therapy using translational readthrough inducing drugs may provide functional rescue of REP1, thus attenuating progressive sight loss. Here, we employed two CHM model systems to systematically test the efficacy and safety of ataluren (PTC124) and its novel analog PTC-414: (1) the chm(ru848) zebrafish, the only nonsense mutation animal model of CHM harbouring a TAA nonsense mutation, and (2) a primary human fibroblast cell line from a CHM patient harbouring a TAG nonsense mutation. PTC124 or PTC-414 treatment of chm(ru848) embryos led to a ∼2.0-fold increase in survival, prevented the onset of retinal degeneration with reduced oxidative stress and apoptosis, increased rep1 protein by 23.1% (PTC124) and 17.2% (PTC-414) and restored biochemical function as confirmed through in vitro prenylation assays (98 ± 2% [PTC124] and 68 ± 5% [PTC-414]). In CHM(Y42X/y) fibroblasts, there was a recovery of prenylation activity following treatment with either PTC124 (42 ± 5%) or PTC-414 (36 ± 11%), although an increase in REP1 protein was not detected in these cells, in contrast to the zebrafish model. This comprehensive study on the use of PTC124 and PTC-414 as successful nonsense suppression agents for the treatment of CHM highlights the translational potential of these drugs for inherited retinal disease. © The Author 2016. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  19. Solar air heaters and their applications

    Science.gov (United States)

    Selcuk, M. K.

    1977-01-01

    The solar air heater appears to be the most logical choice, as far as the ultimate application of heating air to maintain a comfortable environment is concerned. One disadvantage of solar air heaters is the need for handling larger volumes of air than liquids due to the low density of air as a working substance. Another disadvantage is the low thermal capacity of air. In cases where thermal storage is needed, water is superior to air. Design variations of solar air heaters are discussed along with the calculation of the efficiency of a flat plate solar air heater, the performance of various collector types, and the applications of solar air heaters. Attention is given to collectors with nonporous absorber plates, collectors with porous absorbers, the performance of flat plate collectors with finned absorbers, a wire mesh absorber, and an overlapped glass plate air heater.

  20. RET/PTC Translocations and Clinico-Pathological Features in Human Papillary Thyroid Carcinoma.

    Science.gov (United States)

    Romei, Cristina; Elisei, Rossella

    2012-01-01

    Thyroid carcinoma is the most frequent endocrine cancer accounting for 5-10% of thyroid nodules. Papillary histotype (PTC) is the most prevalent form accounting for 80% of all thyroid carcinoma. Although much is known about its epidemiology, pathogenesis, clinical, and biological behavior, the only documented risk factor for PTC is the ionizing radiation exposure. Rearrangements of the Rearranged during Transfection (RET) proto-oncogene are found in PTC and have been shown to play a pathogenic role. The first RET rearrangement, named RET/PTC, was discovered in 1987. This rearrangement constitutively activates the transcription of the RET tyrosine-kinase domain in follicular cell, thus triggering the signaling along the MAPK pathway and an uncontrolled proliferation. Up to now, 13 different types of RET/PTC rearrangements have been reported but the two most common are RET/PTC1 and RET/PTC3. Ionizing radiations are responsible for the generation of RET/PTC rearrangements, as supported by in vitro studies and by the evidence that RET/PTC, and particularly RET/PTC3, are highly prevalent in radiation induced PTC. However, many thyroid tumors without any history of radiation exposure harbor similar RET rearrangements. The overall prevalence of RET/PTC rearrangements varies from 20 to 70% of PTCs and they are more frequent in childhood than in adulthood thyroid cancer. Controversial data have been reported on the relationship between RET/PTC rearrangements and the PTC prognosis. RET/PTC3 is usually associated with a more aggressive phenotype and in particular with a greater tumor size, the solid variant, and a more advanced stage at diagnosis which are all poor prognostic factors. In contrast, RET/PTC1 rearrangement does not correlate with any clinical-pathological characteristics of PTC. Moreover, the RET protein and mRNA expression level did not show any correlation with the outcome of patients with PTC and no correlation between RET/PTC rearrangements and the

  1. Parallel heater system for subsurface formations

    Energy Technology Data Exchange (ETDEWEB)

    Harris, Christopher Kelvin (Houston, TX); Karanikas, John Michael (Houston, TX); Nguyen, Scott Vinh (Houston, TX)

    2011-10-25

    A heating system for a subsurface formation is disclosed. The system includes a plurality of substantially horizontally oriented or inclined heater sections located in a hydrocarbon containing layer in the formation. At least a portion of two of the heater sections are substantially parallel to each other. The ends of at least two of the heater sections in the layer are electrically coupled to a substantially horizontal, or inclined, electrical conductor oriented substantially perpendicular to the ends of the at least two heater sections.

  2. PHENYLTHIOCARBAMIDE (PTC) TASTER STATUS IN SOUTH INDIAN ADULT MEDICAL STUDENTS

    OpenAIRE

    Sachin Rathod; Pallavi Jawale; Suresh Babu Kondaveeti; Chitra Pillai

    2016-01-01

    BACKGROUND The objective of this study was to determine Phenylthiocarbamide (PTC) taster status in adults who are studying medicine and its relationship with anthropometric variables such as Body Mass Index (BMI), Body Fat Percentage (BFP) and pleasantness of sugar, salt, and fat. A total of 112 subjects rated the intensity of Phenylthiocarbamide and sodium chloride (NaCl) solutions using the labelled magnitude scale. For pleasantness evaluation, it was used with concentrated l...

  3. SINGLE HEATER TEST FINAL REPORT

    Energy Technology Data Exchange (ETDEWEB)

    J.B. Cho

    1999-05-01

    The Single Heater Test is the first of the in-situ thermal tests conducted by the U.S. Department of Energy as part of its program of characterizing Yucca Mountain in Nevada as the potential site for a proposed deep geologic repository for the disposal of spent nuclear fuel and high-level nuclear waste. The Site Characterization Plan (DOE 1988) contained an extensive plan of in-situ thermal tests aimed at understanding specific aspects of the response of the local rock-mass around the potential repository to the heat from the radioactive decay of the emplaced waste. With the refocusing of the Site Characterization Plan by the ''Civilian Radioactive Waste Management Program Plan'' (DOE 1994), a consolidated thermal testing program emerged by 1995 as documented in the reports ''In-Situ Thermal Testing Program Strategy'' (DOE 1995) and ''Updated In-Situ Thermal Testing Program Strategy'' (CRWMS M&O 1997a). The concept of the Single Heater Test took shape in the summer of 1995 and detailed planning and design of the test started with the beginning fiscal year 1996. The overall objective of the Single Heater Test was to gain an understanding of the coupled thermal, mechanical, hydrological, and chemical processes that are anticipated to occur in the local rock-mass in the potential repository as a result of heat from radioactive decay of the emplaced waste. This included making a priori predictions of the test results using existing models and subsequently refining or modifying the models, on the basis of comparative and interpretive analyses of the measurements and predictions. A second, no less important, objective was to try out, in a full-scale field setting, the various instruments and equipment to be employed in the future on a much larger, more complex, thermal test of longer duration, such as the Drift Scale Test. This ''shake down'' or trial aspect of the Single Heater Test applied

  4. SELECTED ORGANIC POLLUTANT EMISSIONS FROM UNVENTED KEROSENE HEATERS

    Science.gov (United States)

    An exploratory study was performed to assess the semivolatile and nonvolatile organic pollutant emission rates from unvented kerosene space heaters. A well-tuned radiant heater and maltuned convective heater were tested for semivolatile and nonvolatile organic pollutant emiss...

  5. Strategy Guideline. Proper Water Heater Selection

    Energy Technology Data Exchange (ETDEWEB)

    Hoeschele, M. [Alliance for Residential Building Innovation (ARBI), Davis, CA (United States); Springer, D. [Alliance for Residential Building Innovation (ARBI), Davis, CA (United States); German, A. [Alliance for Residential Building Innovation (ARBI), Davis, CA (United States); Staller, J. [Alliance for Residential Building Innovation (ARBI), Davis, CA (United States); Zhang, Y. [Alliance for Residential Building Innovation (ARBI), Davis, CA (United States)

    2015-04-09

    This Strategy Guideline on proper water heater selection was developed by the Building America team Alliance for Residential Building Innovation to provide step-by-step procedures for evaluating preferred cost-effective options for energy efficient water heater alternatives based on local utility rates, climate, and anticipated loads.

  6. Strategy Guideline: Proper Water Heater Selection

    Energy Technology Data Exchange (ETDEWEB)

    Hoeschele, M. [Alliance for Residential Building Innovation, Davis, CA (United States); Springer, D. [Alliance for Residential Building Innovation, Davis, CA (United States); German, A. [Alliance for Residential Building Innovation, Davis, CA (United States); Staller, J. [Alliance for Residential Building Innovation, Davis, CA (United States); Zhang, Y. [Alliance for Residential Building Innovation, Davis, CA (United States)

    2015-04-01

    This Strategy Guideline on proper water heater selection was developed by the Building America team Alliance for Residential Building Innovation to provide step-by-step procedures for evaluating preferred cost-effective options for energy efficient water heater alternatives based on local utility rates, climate, and anticipated loads.

  7. 49 CFR 393.77 - Heaters.

    Science.gov (United States)

    2010-10-01

    ... all hot water and steam heater systems shall be specifically designed and constructed for that purpose... when used for heating the cargo of tank motor vehicles. (3) Heaters permitting fuel leakage. Any type... air, heated or to be heated, from the engine compartment or from direct contact with any portion...

  8. "Starfish" Heater Head For Stirling Engine

    Science.gov (United States)

    Vitale, N.

    1993-01-01

    Proposed "starfish" heater head for Stirling engine enables safe use of liquid sodium as heat-transfer fluid. Sodium makes direct contact with heater head but does not come in contact with any structural welds. Design concept minimizes number of, and simplifies nonstructural thermal welds and facilitates inspection of such welds.

  9. Solar Water-Heater Design Package

    Science.gov (United States)

    1982-01-01

    Information on a solar domestic-hot water heater is contained in 146 page design package. System consists of solar collector, storage tanks, automatic control circuitry and auxiliary heater. Data-acquisition equipment at sites monitors day-by-day performance. Includes performance specifications, schematics, solar-collector drawings and drawings of control parts.

  10. Subsurface connection methods for subsurface heaters

    Energy Technology Data Exchange (ETDEWEB)

    Vinegar, Harold J. (Bellaire, TX); Bass, Ronald Marshall (Houston, TX); Kim, Dong Sub (Sugar Land, TX); Mason, Stanley Leroy (Allen, TX); Stegemeier, George Leo (Houston, TX); Keltner, Thomas Joseph (Spring, TX); Carl, Jr., Frederick Gordon (Houston, TX)

    2010-12-28

    A system for heating a subsurface formation is described. The system includes a first elongated heater in a first opening in the formation. The first elongated heater includes an exposed metal section in a portion of the first opening. The portion is below a layer of the formation to be heated. The exposed metal section is exposed to the formation. A second elongated heater is in a second opening in the formation. The second opening connects to the first opening at or near the portion of the first opening below the layer to be heated. At least a portion of an exposed metal section of the second elongated heater is electrically coupled to at least a portion of the exposed metal section of the first elongated heater in the portion of the first opening below the layer to be heated.

  11. [Oncogenes RET/PTC and mechanisms of their involvement in thyroid cancerogenesis].

    Science.gov (United States)

    Voskoboĭnyk, L H

    2009-01-01

    Papillary thyroid carcinomas are the most common type of thyroid oncopathology, and are rather often associated with the expression of RET/PTC oncogens. The first oncogen RET/PTC1 was isolated more than 20 years ago. Now 13 different forms of RET/PTC are known, and 12 different partner-genes are described, that could be involved in formation of RET/PTC oncogenes. The most common of them are RET/PTC1 and RET/PTC3 forms. The great majority of oncogens RET/PTC, except for two--ELKS-RET and HOOK3-RET, have been founded in radioaction-induced thyroid tumors. There is an opinion that the key role in development of papillary thyroid carcinomas belongs to RET/PTC oncogens. The data about different types of RET/PTC oncogens, factors, that lead to their formation have been described in the present review. Also different mechanisms of activation of transduction pathways and gene's expression in thyroid cells after RET/PTC induction have been presented.

  12. The Ca2+-calmodulin-dependent kinase II is activated in papillary thyroid carcinoma (PTC) and mediates cell proliferation stimulated by RET/PTC.

    Science.gov (United States)

    Rusciano, Maria Rosaria; Salzano, Marcella; Monaco, Sara; Sapio, Maria Rosaria; Illario, Maddalena; De Falco, Valentina; Santoro, Massimo; Campiglia, Pietro; Pastore, Lucio; Fenzi, Gianfranco; Rossi, Guido; Vitale, Mario

    2010-03-01

    RET/papillary thyroid carcinoma (PTC), TRK-T, or activating mutations of Ras and BRaf are frequent genetic alterations in PTC, all leading to the activation of the extracellular-regulated kinase (Erk) cascade. The aim of this study was to investigate the role of calmodulin-dependent kinase II (CaMKII) in the signal transduction leading to Erk activation in PTC cells. In normal thyroid cells, CaMKII and Erk were in the inactive form in the absence of stimulation. In primary PTC cultures and in PTC cell lines harboring the oncogenes RET/PTC-1 or BRaf(V600E), CaMKII was active also in the absence of any stimulation. Inhibition of calmodulin or phospholipase C (PLC) attenuated the level of CaMKII activation. Expression of recombinant RET/PTC-3, BRaf(V600E), or Ras(V12) induced CaMKII activation. Inhibition of CaMKII attenuated Erk activation and DNA synthesis in thyroid papillary carcinoma (TPC-1), a cell line harboring RET/PTC-1, suggesting that CaMKII is a component of the Erk signal cascade in this cell line. In conclusion, PTCs contain an active PLC/Ca(2+)/calmodulin-dependent signal inducing constitutive activation of CaMKII. This kinase is activated by BRaf(V600E), oncogenic Ras, and by RET/PTC. CaMKII participates to the activation of the Erk pathway by oncogenic Ras and RET/PTC and contributes to their signal output, thus modulating tumor cell proliferation.

  13. Intercellular adhesion molecule 1 is a sensitive and diagnostically useful immunohistochemical marker of papillary thyroid cancer (PTC) and of PTC-like nuclear alterations in Hashimoto's thyroiditis.

    Science.gov (United States)

    Zhang, K E; Ge, Shu-Jian; Lin, Xiao-Yan; Lv, Bei-Bei; Cao, Zhi-Xin; Li, Jia-Mei; Xu, Jia-Wen; Wang, Qiang-Xiu

    2016-03-01

    Intercellular adhesion molecule 1 (ICAM-1) is important in the progression of inflammatory responses. Recently, increased levels of ICAM-1 have been reported in a number of types of malignancy. The present study aimed to investigate ICAM-1 expression in papillary thyroid cancer (PTC) and in Hashimoto's thyroiditis (HT) with PTC-like nuclear alterations, and to assess the predictive value of ICAM-1 in thyroid lesions. ICAM-1 expression was retrospectively investigated in 132 consecutive cases of PTC, 72 cases of HT, 10 of follicular cancer, 15 of follicular adenoma, 16 of nodular goiter and 8 samples of normal thyroid tissue using immunohistochemical analyses, and in 42 PTC patients using western blotting. ICAM-1 expression was not detected in normal follicular cells, follicular lesions (adenoma and cancer) and benign nodular hyperplasia, but was frequently overexpressed in PTC cells. ICAM-1 overexpression was associated with extra-thyroidal invasion and lymph node metastasis; no association was found with age, gender, tumor size, multifocality, pathological stage, recurrence or distant metastasis. ICAM-1 expression in HT patients with PTC-like nuclear alterations was significantly higher than that in HT cases with non-PTC-like features. Compared with antibodies against cytokeratin 19, galectin-3 and Hector Battifora mesothelial-1, ICAM-1 was the most sensitive marker for the detection of PTC-like features in HT. These findings demonstrate that ICAM-1 expression is upregulated in PTC and in HT with PTC-like nuclear alterations. This feature may be an important factor in the progression of cancer of the thyroid gland.

  14. Effects of heated seat and foot heater on thermal comfort and heater energy consumption in vehicle.

    Science.gov (United States)

    Oi, Hajime; Yanagi, Kotaro; Tabata, Koji; Tochihara, Yutaka

    2011-08-01

    Subjective experiments involving 12 different conditions were conducted to investigate the effects of heated seats and foot heaters in vehicles on thermal sensation and thermal comfort. The experimental conditions involved various combinations of the operative temperature in the test room (10 or 20°C), a heated seat (on/off) and a foot heater (room operative temperature +10 or +20°C). The heated seat and foot heater improved the occupant's thermal sensation and comfort in cool environments. The room operative temperature at which the occupants felt a 'neutral' overall thermal sensation was decreased by about 3°C by using the heated seat or foot heater and by about 6°C when both devices were used. Moreover, the effects of these devices on vehicle heater energy consumption were investigated using simulations. As a result, it was revealed that heated seats and foot heaters can reduce the total heater energy consumption of vehicles. Statement of Relevance: Subjective experiments were conducted to investigate the effects of heated seats and foot heaters in vehicles on thermal comfort. The heated seat and foot heater improved the occupant's thermal sensation and comfort in cool environments. These devices can reduce the total heater energy consumption in vehicles.

  15. Concomitant RAS, RET/PTC, or BRAF mutations in advanced stage of papillary thyroid carcinoma.

    Science.gov (United States)

    Zou, Minjing; Baitei, Essa Y; Alzahrani, Ali S; BinHumaid, Faisal S; Alkhafaji, Dania; Al-Rijjal, Roua A; Meyer, Brian F; Shi, Yufei

    2014-08-01

    RET/PTC rearrangement, RAS, and BRAF mutations are considered to be mutually exclusive in papillary thyroid carcinoma (PTC). However, although concomitant mutations of RET/PTC, RAS, or BRAF have been reported recently, their significance for tumor progression and survival remains unclear. We sought to examine the prognostic value of concomitant mutations in PTC. We investigated 88 PTC for concomitant mutations. Mutation in BRAF exon 15, KRAS, NRAS, and HRAS were studied by polymerase chain reaction (PCR)-sequencing of tumor DNA; RET/PTC rearrangement was determined by reverse transcription (RT)-PCR-sequencing of tumor cDNA. BRAF(V600E) was detected in 39 of 82 classic PTC (CPTC) and in all three tall-cell variants (49%, 42/85). KRAS mutation (p.Q61R and p.S65N) was detected in two CPTC (2%, 2/88) and NRAS(Q61R) in one CPTC and two follicular variant PTC (FVPTC; 3%, 3/88). KRAS(S65N) was identified for the first time in thyroid cancer and could activate mitogen-associated protein kinase (MAPK). RET/PTC-1 was detected in nine CPTC, one tall-cell variant, and two FVPTC. Concomitant BRAF(V600E) and KRAS, or BRAF(V600E) and RET/PTC-1 mutations were found in two CPTC, and six CPTC and one tall-cell variant, respectively. In total, 11 concomitant mutations were found in 88 PTC samples (13%), and most of them were in the advanced stage of disease (8/11, 73%; pPTC and are associated with poor prognosis. The concomitant mutations may represent intratumor heterogeneity and could exert a gene dosage effect to promote disease progression. KRAS(S65N) can constitutively activate the MAPK pathway.

  16. Biogas Digester with Simple Solar Heater

    OpenAIRE

    Kh S Karimov; Muhammad Abid

    2012-01-01

    ABSTRACT: In this research work, the design, fabrication and investigation of a biogas digester with simple solar heater are presented. For the solar heater, a built-in reverse absorber type heater was used. The maximum temperature (50°C) inside the methane tank was taken as a main parameter for the design of the digester. Then, the energy balance equation for the case of a static mass of fluid being heated was used to model the process. The parameters of thermal insulation of the methane tan...

  17. Particulate matter sensor with a heater

    Science.gov (United States)

    Hall, Matthew

    2011-08-16

    An apparatus to detect particulate matter. The apparatus includes a sensor electrode, a shroud, and a heater. The electrode measures a chemical composition within an exhaust stream. The shroud surrounds at least a portion of the sensor electrode, exclusive of a distal end of the sensor electrode exposed to the exhaust stream. The shroud defines an air gap between the sensor electrode and the shroud and an opening toward the distal end of the sensor electrode. The heater is mounted relative to the sensor electrode. The heater burns off particulate matter in the air gap between the sensor electrode and the shroud.

  18. Regulation of Protein Kinase B Tyrosine Phosphorylation by Thyroid-Specific Oncogenic RET/PTC Kinases

    National Research Council Canada - National Science Library

    Jung, Hye Sook; Kim, Dong Wook; Jo, Young Suk; Chung, Hyo Kyun; Song, Jung Hun; Park, Jong Sun; Park, Ki Cheol; Park, Su Hyeon; Hwang, Jung Hwan; Jo, Ki-Won; Shong, Minho

    2005-01-01

    Papillary thyroid carcinoma (PTC) is a heterogenous disorder characterized by unique gene rearrangements and gene mutations that activate signaling pathways responsible for cellular transformation, survival, and antiapoptosis...

  19. PTC MathCAD and Workgroup Manager: Implementation in a Multi-Org System

    Science.gov (United States)

    Jones, Corey

    2015-01-01

    In this presentation, the presenter will review what was done at Kennedy Space Center to deploy and implement PTC MathCAD and PTC Workgroup Manager in a multi-org system. During the presentation the presenter will explain how they configured PTC Windchill to create custom soft-types and object initialization rules for their custom numbering scheme and why they choose these methods. This presentation will also include how to modify the EPM default soft-type file in the PTC Windchill server codebase folder. The presenter will also go over the code used in a start up script to initiate PTC MathCAD and PTC Workgroup Manager in the proper order, and also set up the environment variables when running both PTC Workgroup Manager and PTC Creo. The configuration.ini file the presenter used will also be reviewed to show you how to set up the PTC Workgroup Manager and customized it to their user community. This presentation will be of interest to administrators trying to create a similar set-up in either a single org or multiple org system deployment. The big take away will be ideas and best practices learned through implementing this system, and the lessons learned what to do and not to do when setting up this configuration. Attendees will be exposed to several different sets of code used and that worked well and will hear some limitations on what the software can accomplish when configured this way.

  20. Preparation of Polyacrylate-based Conductive Coatings and Its PTC Effect

    Institute of Scientific and Technical Information of China (English)

    XIONG Chuan-xi; HU Hui-rong; ZHOU Zhi-yong; ZHANG Yi; DONG Li-jie

    2004-01-01

    Polyacrylate- based conductive coatings were prepared from polyacrylate emulsion as matrix andcarbon black (CB) whose surface was treated with titanate coupling agent as conducting particles. One kind oforganic crystal was added to study its effects on the electrical conductivity and PTC ( positive temperature coeffi-cient ) effect of the conductive coatings. Experimental results show that the coatings containing only polyacrylateemulsion and CB exhibit an excellent electrical conductivity but bad PTC effect, and when organic crystal is added,PTC effect is characterized and can increase by 2 orders of magtitude. The critical transformation temperature ofpolyacrylate emulsion/CB PTC composites is decided by melting point of organic crystals.

  1. 46 CFR 52.25-15 - Fired thermal fluid heaters.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 2 2010-10-01 2010-10-01 false Fired thermal fluid heaters. 52.25-15 Section 52.25-15... Boiler Types § 52.25-15 Fired thermal fluid heaters. (a) Fired thermal fluid heaters shall be designed...) Each fired thermal fluid heater must be fitted with a control which prevents the heat transfer...

  2. 40 CFR 65.149 - Boilers and process heaters.

    Science.gov (United States)

    2010-07-01

    ... thermal units per hour) or greater. (ii) A boiler or process heater into which the vent stream is... 40 Protection of Environment 15 2010-07-01 2010-07-01 false Boilers and process heaters. 65.149... System or a Process § 65.149 Boilers and process heaters. (a) Boiler and process heater equipment...

  3. 46 CFR 63.25-5 - Fired thermal fluid heaters.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 2 2010-10-01 2010-10-01 false Fired thermal fluid heaters. 63.25-5 Section 63.25-5... heaters. (a) Construction. Fired thermal fluid heaters must meet the requirements of part 52 of this chapter, as applicable. (b) Controls. Fired thermal fluid heaters must have a low fluid level...

  4. Design criteria for stable Pt/C fuel cell catalysts.

    Science.gov (United States)

    Meier, Josef C; Galeano, Carolina; Katsounaros, Ioannis; Witte, Jonathon; Bongard, Hans J; Topalov, Angel A; Baldizzone, Claudio; Mezzavilla, Stefano; Schüth, Ferdi; Mayrhofer, Karl J J

    2014-01-01

    Platinum and Pt alloy nanoparticles supported on carbon are the state of the art electrocatalysts in proton exchange membrane fuel cells. To develop a better understanding on how material design can influence the degradation processes on the nanoscale, three specific Pt/C catalysts with different structural characteristics were investigated in depth: a conventional Pt/Vulcan catalyst with a particle size of 3-4 nm and two Pt@HGS catalysts with different particle size, 1-2 nm and 3-4 nm. Specifically, Pt@HGS corresponds to platinum nanoparticles incorporated and confined within the pore structure of the nanostructured carbon support, i.e., hollow graphitic spheres (HGS). All three materials are characterized by the same platinum loading, so that the differences in their performance can be correlated to the structural characteristics of each material. The comparison of the activity and stability behavior of the three catalysts, as obtained from thin film rotating disk electrode measurements and identical location electron microscopy, is also extended to commercial materials and used as a basis for a discussion of general fuel cell catalyst design principles. Namely, the effects of particle size, inter-particle distance, certain support characteristics and thermal treatment on the catalyst performance and in particular the catalyst stability are evaluated. Based on our results, a set of design criteria for more stable and active Pt/C and Pt-alloy/C materials is suggested.

  5. Modeling of PEM fuel cell Pt/C catalyst degradation

    Science.gov (United States)

    Bi, Wu; Fuller, Thomas F.

    Pt/C catalyst degradation remains as one of the primary limitations for practical applications of proton exchange membrane (PEM) fuel cells. Pt catalyst degradation mechanisms with the typically observed Pt nanoparticle growth behaviors have not been completely understood and predicted. In this work, a physics-based Pt/C catalyst degradation model is proposed with a simplified bi-modal particle size distribution. The following catalyst degradation processes were considered: (1) dissolution of Pt and subsequent electrochemical deposition on Pt nanoparticles in cathode; (2) diffusion of Pt ions in the membrane electrode assembly (MEA); and (3) Pt ion chemical reduction in membrane by hydrogen permeating through the membrane from the negative electrode. Catalyst coarsening with Pt nanoparticle growth was clearly demonstrated by Pt mass exchange between small and large particles through Pt dissolution and Pt ion deposition. However, the model is not adequate to predict well the catalyst degradation rates including Pt nanoparticle growth, catalyst surface area loss and cathode Pt mass loss. Additional catalyst degradation processes such as new Pt cluster formation on carbon support and neighboring Pt clusters coarsening was proposed for further simulative investigation.

  6. Design criteria for stable Pt/C fuel cell catalysts

    Directory of Open Access Journals (Sweden)

    Josef C. Meier

    2014-01-01

    Full Text Available Platinum and Pt alloy nanoparticles supported on carbon are the state of the art electrocatalysts in proton exchange membrane fuel cells. To develop a better understanding on how material design can influence the degradation processes on the nanoscale, three specific Pt/C catalysts with different structural characteristics were investigated in depth: a conventional Pt/Vulcan catalyst with a particle size of 3–4 nm and two Pt@HGS catalysts with different particle size, 1–2 nm and 3–4 nm. Specifically, Pt@HGS corresponds to platinum nanoparticles incorporated and confined within the pore structure of the nanostructured carbon support, i.e., hollow graphitic spheres (HGS. All three materials are characterized by the same platinum loading, so that the differences in their performance can be correlated to the structural characteristics of each material. The comparison of the activity and stability behavior of the three catalysts, as obtained from thin film rotating disk electrode measurements and identical location electron microscopy, is also extended to commercial materials and used as a basis for a discussion of general fuel cell catalyst design principles. Namely, the effects of particle size, inter-particle distance, certain support characteristics and thermal treatment on the catalyst performance and in particular the catalyst stability are evaluated. Based on our results, a set of design criteria for more stable and active Pt/C and Pt-alloy/C materials is suggested.

  7. Varying properties along lengths of temperature limited heaters

    Energy Technology Data Exchange (ETDEWEB)

    Vinegar, Harold J. (Bellaire, TX); Xie, Xueying (Houston, TX); Miller, David Scott (Katy, TX); Ginestra, Jean Charles (Richmond, TX)

    2011-07-26

    A system for heating a subsurface formation is described. The system includes an elongated heater in an opening in the formation. The elongated heater includes two or more portions along the length of the heater that have different power outputs. At least one portion of the elongated heater includes at least one temperature limited portion with at least one selected temperature at which the portion provides a reduced heat output. The heater is configured to provide heat to the formation with the different power outputs. The heater is configured so that the heater heats one or more portions of the formation at one or more selected heating rates.

  8. Experimental studies of operating characteristics of a downhole electric heater

    Energy Technology Data Exchange (ETDEWEB)

    Simkin, E.M.; Sergeev, A.I.; Sheinman, A.B.

    1967-06-01

    A new type of electric downhole heater for deparaffinization and heating of formations in oil wells is described. The heater is a hollow hermetic cylinder, which contains an electrode insulated from the body of the heater. The cylinder contains a predetemined volume of water of fixed electrical resistance. Resistance of this water is adjusted by addition of salt. A cable supplying the electrode with electric current also ground the heater by body. The current passes through the water, heats it, and produces steam. The steam heats up the hermetically sealed body of the heater, and heat flows to the well fluid around the heater. A schematic diagram of the heater is shown. Thermal output of the heater depends on current supplied, dimension of heater and components, resistance and volume of water in heater, and other parameters. All these factors are correlated with heat output by a series of graphs and equations.

  9. Slat Heater Boxes for Thermal Vacuum Testing

    Science.gov (United States)

    Ungar, Eugene

    2003-01-01

    Slat heater boxes have been invented for controlling the sink temperatures of objects under test in a thermal vacuum chamber, the walls of which are cooled to the temperature of liquid nitrogen. A slat heater box (see Figure 1) includes a framework of struts that support electrically heated slats that are coated with a high-emissivity optically gray paint. The slats can be grouped together into heater zones for the purpose of maintaining an even temperature within each side. The sink temperature of an object under test is defined as the steady-state temperature of the object in the vacuum/ radiative environment during the absence of any internal heat source or sink. The slat heater box makes it possible to closely control the radiation environment to obtain a desired sink temperature. The slat heater box is placed inside the cold thermal vacuum chamber, and the object under test is placed inside (but not in contact with) the slat heater box. The slat heaters occupy about a third of the field of view from any point on the surface of the object under test, the remainder of the field of view being occupied by the cold chamber wall. Thus, the radiation environment is established by the combined effects of the slat heater box and the cold chamber wall. Given (1) the temperature of the chamber wall, (2) the fractions of the field of view occupied by the chamber wall and the slat heater box, and (3) the emissivities of the slats, chamber wall, and the surface of object under test, the slat temperature required to maintain a desired sink temperature can be calculated by solving the equations of gray-body radiation for the steady-state adiabatic case (equal absorption and emission by the object under test). Slat heater boxes offer an important advantage over the infrared lamps that have been previously used to obtain desired sink temperatures: In comparison with an infrared lamp, a slat heater box provides a greater degree of sink temperature uniformity for a test

  10. Diesel particulate filter with zoned resistive heater

    Science.gov (United States)

    Gonze, Eugene V [Pinckney, MI

    2011-03-08

    A diesel particulate filter assembly comprises a diesel particulate filter (DPF) and a heater assembly. The DPF filters a particulate from exhaust produced by an engine. The heater assembly has a first metallic layer that is applied to the DPF, a resistive layer that is applied to the first metallic layer, and a second metallic layer that is applied to the resistive layer. The second metallic layer is etched to form a plurality of zones.

  11. Note: Improved wire-wound heater.

    Science.gov (United States)

    Steinmann, Ricardo G; Vitoux, Hugo

    2015-01-01

    The authors have measured, at cryogenic temperature, the upper limit of the heat transfer in different configurations of a wire-wound heater. We found that the heat transferred has an upper limit of about 15 W/cm(2) and is dependent on the diameter of the wire. In this paper, we present three ways of increasing the heat transferred by this type of heater and its application in different continuous flow cryostats.

  12. Note: Improved wire-wound heater

    Science.gov (United States)

    Steinmann, Ricardo G.; Vitoux, Hugo

    2015-01-01

    The authors have measured, at cryogenic temperature, the upper limit of the heat transfer in different configurations of a wire-wound heater. We found that the heat transferred has an upper limit of about 15 W/cm2 and is dependent on the diameter of the wire. In this paper, we present three ways of increasing the heat transferred by this type of heater and its application in different continuous flow cryostats.

  13. Intelligent annunciator for solar water heater

    Science.gov (United States)

    Chen, Xiao

    2009-07-01

    The solar water heater has advantages of low cost, no pollution, safety, energy conservation and is very suitable for users in rural area. But many now used solar water heater has no alarm device resulting water and resource wasting because of forgetting to turn off the valve after water sailing upstream. To overcome this defect, an intelligent annunciator for solar water heater installed at the end of the return pipe is presented and designed in order to remind the user. Firstly, the advantages and disadvantages of automatic and manual sailing upstream are compared concluding that manual sailing upstream is more trustiness. Then an annunciator for solar water heater is studied and ameliorated. Its principle, parameters index and functions are introduced. The annunciator uses CD4069 chip as the core circuit with very little assistant circuit. It can provide sound and light alarm at the same time. This annunciator for solar water heater water is very simple in production, low cost, the use of safe and convenient. The annunciator is applicable to all solar power products, including various types of early installation of solar power water heaters and water tanks without changing their structures. It can meet family and industrial environmental applications.

  14. Design, Construction, and Qualification of a Microscale Heater Array for Use in Boiling Heat Transfer

    Science.gov (United States)

    Rule, T. D.; Kim, J.; Kalkur, T. S.

    1998-01-01

    Boiling heat transfer is an efficient means of heat transfer because a large amount of heat can be removed from a surface using a relatively small temperature difference between the surface and the bulk liquid. However, the mechanisms that govern boiling heat transfer are not well understood. Measurements of wall temperature and heat flux near the wall would add to the database of knowledge which is necessary to understand the mechanisms of nucleate boiling. A heater array has been developed which contains 96 heater elements within a 2.5 mm square area. The temperature of each heater element is held constant by an electronic control system similar to a hot-wire anemometer. The voltage that is being applied to each heater element can be measured and digitized using a high-speed A/D converter, and this digital information can be compiled into a series of heat-flux maps. Information for up to 10,000 heat flux maps can be obtained each second. The heater control system, the A/D system and the heater array construction are described in detail. Results are presented which show that this is an effective method of measuring the local heat flux during nucleate and transition boiling. Heat flux maps are obtained for pool boiling in FC-72 on a horizontal surface. Local heat flux variations are shown to be three to six times larger than variations in the spatially averaged heat flux.

  15. Tasting Phenylthiocarbamide (PTC): A New Integrative Genetics Lab with an Old Flavor

    Science.gov (United States)

    Merritt, Robert B.; Bierwert, Lou Ann; Slatko, Barton; Weiner, Michael P.; Ingram, Jessica; Sciarra, Kristianna; Weiner, Evan

    2008-01-01

    First reported in the early 1930s, variation in the ability to taste phenylthiocarbamide (PTC) has since become one of the most widely studied of all human genetic traits. Guo and Reed (2001) provide an excellent review of work on this polymorphism prior to the identification and sequencing of the PTC gene by Kim et al. (2003), and Wooding (2006)…

  16. 49 CFR 236.1029 - PTC system use and en route failures.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false PTC system use and en route failures. 236.1029..., INSPECTION, MAINTENANCE, AND REPAIR OF SIGNAL AND TRAIN CONTROL SYSTEMS, DEVICES, AND APPLIANCES Positive Train Control Systems § 236.1029 PTC system use and en route failures. (a) When any safety-critical...

  17. Relationship of Phenylthiocarbamide (PTC) Taster Status to Olfactory and Gustatory Function in Patients with Chemosensory Disturbances.

    Science.gov (United States)

    Doty, Richard L; De Fonte, Tatiana Prosini

    2016-10-01

    Poor sensitivity to the bitter taste of phenylthiocarbamide (PTC) and related substances has been associated with a number of diseases. We determined, in patients with chemosensory dysfunction from multiple etiologies, whether PTC "tasters" (n = 511) exhibit less smell and taste dysfunction than their non-PTC-tasting counterparts (n = 432) on a comprehensive battery of olfactory and gustatory tests. The proportion of tasters (54%) in our study population was much lower than that calculated from 11 North American population studies (76.5%; P PTC tasters (P PTC tasting status was unrelated to scores on the olfactory tests (which included tests of odor identification, detection threshold, and odor memory/discrimination), tasters significantly outperformed nontasters on suprathreshold identification and intensity taste tests employing both bitter (caffeine) and nonbitter (sucrose, citric acid, sodium chloride) tasting stimuli. Regardless of PTC taster status, women outperformed men on the taste tests. Our findings suggest the possibility that the T2R38 gene may protect against significant olfactory dysfunction, but once such dysfunction becomes manifest at a level where professional help is sought, such protection is not evident. However, other hypotheses for this phenomenon are possible. This study demonstrates that patients with chemosensory disturbances who are PTC tasters outperform their non-PTC taster counterparts in both identifying and perceiving the intensity of a range of suprathreshold tastants, including ones that do not taste bitter. © The Author 2016. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  18. Tasting Phenylthiocarbamide (PTC): A New Integrative Genetics Lab with an Old Flavor

    Science.gov (United States)

    Merritt, Robert B.; Bierwert, Lou Ann; Slatko, Barton; Weiner, Michael P.; Ingram, Jessica; Sciarra, Kristianna; Weiner, Evan

    2008-01-01

    First reported in the early 1930s, variation in the ability to taste phenylthiocarbamide (PTC) has since become one of the most widely studied of all human genetic traits. Guo and Reed (2001) provide an excellent review of work on this polymorphism prior to the identification and sequencing of the PTC gene by Kim et al. (2003), and Wooding (2006)…

  19. Estimating the recombination frequency for the PTC-Kell linkage.

    Science.gov (United States)

    Anne-Spence, M; Falk, C T; Neiswanger, K; Field, L L; Marazita, M L; Allen, F H; Siervogel, R M; Roche, A F; Crandall, B F; Sparkes, R S

    1984-01-01

    Two data sets are analyzed for linkage between the PTC and Kell blood group loci. The original report of close linkage for these loci was that of Conneally et al. (1976), where the maximum likelihood estimate of theta was 0.05. These two new data sets give a combined maximum likelihood estimate of theta m = f = 0.28. Estimating the recombination frequency for the sexes separately gave theta m = 0.29, theta f = 0.23. The combined maximum likelihood estimate over all published data sets including this report is theta m = f = 0.14, Zmax = 8.94. There is statistically significant evidence of heterogeneity among the published studies.

  20. Optimization study of using PTC for human body heating dissipation

    Directory of Open Access Journals (Sweden)

    Tiberiu Adrian SALAORU

    2014-06-01

    Full Text Available A better knowledge of the human body heat loses mechanisms is important for both diminishing the number of deaths during the surgical procedures of the patients under effect of full anaesthesia and increasing the efficiency of the Heating, Ventilation and Air Conditioning (HVAC systems. For these studies it is necessary to manufacture a human body mannequin having its surface temperature maintained on a value close to the real human body temperature. A number of PTC (Positive Temperature Coefficient thermistors placed on the entire external surface of the mannequin can be used for this purpose. This paper presents a study of the transient heating regime and the stability of the maintained temperature, performed on these devices.

  1. Performance Study of Swimming Pool Heaters

    Energy Technology Data Exchange (ETDEWEB)

    McDonald, R.J.

    2009-01-01

    The objective of this report is to perform a controlled laboratory study on the efficiency and emissions of swimming pool heaters based on a limited field investigation into the range of expected variations in operational parameters. Swimming pool heater sales trends have indicated a significant decline in the number of conventional natural gas-fired swimming pool heaters (NGPH). On Long Island the decline has been quite sharp, on the order of 50%, in new installations since 2001. The major portion of the decline has been offset by a significant increase in the sales of electric powered heat pump pool heaters (HPPH) that have been gaining market favor. National Grid contracted with Brookhaven National Laboratory (BNL) to measure performance factors in order to compare the relative energy, environmental and economic consequences of using one technology versus the other. A field study was deemed inappropriate because of the wide range of differences in actual load variations (pool size), geographic orientations, ground plantings and shading variations, number of hours of use, seasonal use variations, occupancy patterns, hour of the day use patterns, temperature selection, etc. A decision was made to perform a controlled laboratory study based on a limited field investigation into the range of expected operational variations in parameters. Critical to this are the frequency of use, temperature selection, and sizing of the heater to the associated pool heating loads. This would be accomplished by installing a limited amount of relatively simple compact field data acquisition units on selected pool installations. This data included gas usage when available and alternately heater power or gas consumption rates were inferred from the manufacturer's specifications when direct metering was not available in the field. Figure 1 illustrates a typical pool heater installation layout.

  2. Performance characterization of a hydrogen catalytic heater.

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, Terry Alan; Kanouff, Michael P.

    2010-04-01

    This report describes the performance of a high efficiency, compact heater that uses the catalytic oxidation of hydrogen to provide heat to the GM Hydrogen Storage Demonstration System. The heater was designed to transfer up to 30 kW of heat from the catalytic reaction to a circulating heat transfer fluid. The fluid then transfers the heat to one or more of the four hydrogen storage modules that make up the Demonstration System to drive off the chemically bound hydrogen. The heater consists of three main parts: (1) the reactor, (2) the gas heat recuperator, and (3) oil and gas flow distribution manifolds. The reactor and recuperator are integrated, compact, finned-plate heat exchangers to maximize heat transfer efficiency and minimize mass and volume. Detailed, three-dimensional, multi-physics computational models were used to design and optimize the system. At full power the heater was able to catalytically combust a 10% hydrogen/air mixture flowing at over 80 cubic feet per minute and transfer 30 kW of heat to a 30 gallon per minute flow of oil over a temperature range from 100 C to 220 C. The total efficiency of the catalytic heater, defined as the heat transferred to the oil divided by the inlet hydrogen chemical energy, was characterized and methods for improvement were investigated.

  3. Dielectric Heaters for Testing Spacecraft Nuclear Reactors

    Science.gov (United States)

    Sims, William Herbert; Bitteker, Leo; Godfroy, Thomas

    2006-01-01

    A document proposes the development of radio-frequency-(RF)-driven dielectric heaters for non-nuclear thermal testing of the cores of nuclear-fission reactors for spacecraft. Like the electrical-resistance heaters used heretofore for such testing, the dielectric heaters would be inserted in the reactors in place of nuclear fuel rods. A typical heater according to the proposal would consist of a rod of lossy dielectric material sized and shaped like a fuel rod and containing an electrically conductive rod along its center line. Exploiting the dielectric loss mechanism that is usually considered a nuisance in other applications, an RF signal, typically at a frequency .50 MHz and an amplitude between 2 and 5 kV, would be applied to the central conductor to heat the dielectric material. The main advantage of the proposal is that the wiring needed for the RF dielectric heating would be simpler and easier to fabricate than is the wiring needed for resistance heating. In some applications, it might be possible to eliminate all heater wiring and, instead, beam the RF heating power into the dielectric rods from external antennas.

  4. 49 CFR 236.1013 - PTC Development Plan and Notice of Product Intent content requirements and Type Approval.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false PTC Development Plan and Notice of Product Intent... TRAIN CONTROL SYSTEMS, DEVICES, AND APPLIANCES Positive Train Control Systems § 236.1013 PTC Development Plan and Notice of Product Intent content requirements and Type Approval. (a) For a PTC system to...

  5. Hollow cathode heater development for the Space Station plasma contactor

    Science.gov (United States)

    Soulas, George C.

    1993-01-01

    A hollow cathode-based plasma contactor has been selected for use on the Space Station. During the operation of the plasma contactor, the hollow cathode heater will endure approximately 12000 thermal cycles. Since a hollow cathode heater failure would result in a plasma contactor failure, a hollow cathode heater development program was established to produce a reliable heater design. The development program includes the heater design, process documents for both heater fabrication and assembly, and heater testing. The heater design was a modification of a sheathed ion thruster cathode heater. Three heaters have been tested to date using direct current power supplies. Performance testing was conducted to determine input current and power requirements for achieving activation and ignition temperatures, single unit operational repeatability, and unit-to-unit operational repeatability. Comparisons of performance testing data at the ignition input current level for the three heaters show the unit-to-unit repeatability of input power and tube temperature near the cathode tip to be within 3.5 W and 44 degrees C, respectively. Cyclic testing was then conducted to evaluate reliability under thermal cycling. The first heater, although damaged during assembly, completed 5985 ignition cycles before failing. Two additional heaters were subsequently fabricated and have completed 3178 cycles to date in an on-going test.

  6. Primary helium heater for propellant pressurization systems

    Science.gov (United States)

    Reichmuth, D. M.; Nguyen, T. V.; Pieper, J. L.

    1991-01-01

    The primary helium heater is a unique design that provides direct heating of pressurant gas for large pressure fed propulsion systems. It has been conceptually designed to supply a heated (800-1000 R) pressurization gas to both a liquid oxygen and an RP-1 propellant tank. This pressurization gas is generated within the heater by mixing super critical helium (40-300 R and 3000-1600 psi) with an appropriate amount of combustion products from a 4:1 throttling stoichiometric LO2/LH2 combustor. This simple, low cost and reliable mixer utilizes the large quantity of helium to provide stoichiometric combustor cooling, extend the throttling limits and enhance the combustion stability margin. Preliminary combustion, thermal, and CFD analyses confirm that this low-pressure-drop direct helium heater can provide the constant-temperature pressurant suitable for tank pressurization of both fuel and oxidizer tanks of large pressure fed vehicles.

  7. Economic analysis of residential solar water heaters

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-09-23

    A typical residential solar water heater, and typical cost and performance information are described briefly. The monthly costs and savings of the typical system are discussed. Economic evaluations of solar water heaters are presented in increasingly complex levels of detail. Utilizing a typical system, the effective interest rate that the purchaser of a system would receive on money invested is shown for all regions of the country. The importance of numerous variables that can make a significant difference on the economics of the system is described. Methods for calculating the Payback Period for any non-typical solar water heater are described. This calculated Payback Period is then shown to be related to the effective interest rate that the puchaser of the system would receive for a typical set of economic conditions. A method is presented to calculate the effective interest rate that the solar system would provide. (MHR)

  8. [Pooled Analysis of RET/PTC Gene Rearrangement Rate in Sporadic and Radiogenic Thyroid Papillary Carcinoma].

    Science.gov (United States)

    Ushenkova, L N; Koterov, A N; Biryukov, A P

    2015-01-01

    The database of publications on molecular epidemiology of RET/PTC rearrangements in sporadic and radiogenic thyroid papillary carcinoma has been formed (197 sources at the end of 2014; coverage of 100%). Based on this database a pooled analysis of data on the rates of RET/PTC1, RET/PTC3 and RET/PTC in total was conducted. Statistical approach involves a simple pooling, as well as calculations on the models of random and fixed effects. Since almost all the strata were characterized by heterogeneity, simple pooling and random effect models were adequate. Calculations using both models led to almost identical results. For rates of RET/PTC1, RET/PTC3 and RET/PTC in total with respect to formed carcinoma striations the following values (pooling, in %) were obtained: sporadic, total--13.2; 8.9; 21.2; sporadic, adults--13.3; 9.9; 21.1; sporadic, children--22.4; 17.5; 44.5; radiogenic, total--20.9; 20.3; 40.4; radiotherapy (exposure in childhood)--31.1; 11.8; 42.5; children affected after the Chernobyl accident--19.9; 23.6; 46.1; radiological incidents (exposure in adulthood)--19.9; 7.7; 18.4. Statistically proven is the reliability of differences of carcinoma indicators for children compared with adults (both sporadic and radiogenic tumors) and for radiogenic cancer compared with sporadic. The greatest increase in rate after irradiation was found for RET/PTC1, previously characterized in vitro as one of radiogenic types of RET/PTC.

  9. Measure Guideline. Transitioning to a Tankless Water Heater

    Energy Technology Data Exchange (ETDEWEB)

    Brozyna, K. [IBACOS, Inc., Pittsburgh, PA (United States); Rapport, A. [IBACOS, Inc., Pittsburgh, PA (United States)

    2012-09-01

    This measure guideline provides information to help residential builders and retrofitters with the design, specification, selection, implementation, installation, and maintenance issues of transitioning from tank-type water heaters to tankless water heaters.

  10. The Characteristics and Applied Limits for the Test Code ASME PTC6 and ASME PTC46%发电设备性能试验规程ASME PTC6与ASME PTC46的特点及适用范围

    Institute of Scientific and Technical Information of China (English)

    王兴平

    2003-01-01

    对美国机械工程师协会汽轮机及全厂性试验规程ASME PTC6与ASME PTC46的目的、方法、边界条件等作了分析论述,着重介绍了ASME PTC46的特点和方法,并根据国内的实际情况,并提出了实际应用方面的建议.表1参4

  11. PHENYLTHIOCARBAMIDE (PTC TASTER STATUS IN SOUTH INDIAN ADULT MEDICAL STUDENTS

    Directory of Open Access Journals (Sweden)

    Sachin Rathod

    2016-06-01

    Full Text Available BACKGROUND The objective of this study was to determine Phenylthiocarbamide (PTC taster status in adults who are studying medicine and its relationship with anthropometric variables such as Body Mass Index (BMI, Body Fat Percentage (BFP and pleasantness of sugar, salt, and fat. A total of 112 subjects rated the intensity of Phenylthiocarbamide and sodium chloride (NaCl solutions using the labelled magnitude scale. For pleasantness evaluation, it was used with concentrated lemon juice (sugar and mashed potato (salt and fat. The subjects were classified as non-tasters (n=32, medium-tasters (n=31 and super-tasters (n=49. In this study, no relationship was found between phenylthiocarbamide taster status and age, sex, weight, body mass index, and pleasantness. Although genetic markers may influence the degree of liking of certain foods, one must consider that the mechanisms influencing eating behaviour in humans are complex, and that psychological, social, and economic factors play a key role in response to food.

  12. 40 CFR 63.988 - Incinerators, boilers, and process heaters.

    Science.gov (United States)

    2010-07-01

    ... bed. (3) Where a boiler or process heater of less than 44 megawatts (150 million British thermal units... heaters. 63.988 Section 63.988 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR... Routing to a Fuel Gas System or a Process § 63.988 Incinerators, boilers, and process heaters....

  13. Heater size effect on subcooled pool boiling of FC-72

    Energy Technology Data Exchange (ETDEWEB)

    Raj, Rishi; Kim, Jungho [University of Maryland, College Park, MD (United States). Dept. of Mechanical Engineering

    2009-07-01

    Extensive research has been conducted on pool boiling using heaters larger than the capillary length. For large heaters and/or high gravity conditions, boiling is dominated by buoyancy, and the heat transfer is heater size independent. Much less is known about boiling on small heaters and at low gravity levels. The ratio of heater size L{sub h} to capillary length L{sub c} is an important parameter in the determination of heater size dependence on heat transfer. As the ratio L{sub h}/L{sub c} decreases due to a decrease in either heater size or gravity, surface tension forces become dominant. It is proposed that transition from buoyancy to surface tension dominated boiling occurs when the heater size and bubble departure diameter are of the same order. Previous work in variable gravity with flat surfaces has shown that the heat transfer was heater size independent only when the ratio L{sub h}/L{sub c} was considerably larger than 1. An array of 96 platinum resistance heater elements in a 10 x 10 configuration with individual elements 0.7 x 0.7 mm{sup 2} in size was used to vary heater size and measure the heat transfer. The threshold value of L{sub h}/L{sub c} above which pool boiling is heater size independent was found to be about 2.8. (author)

  14. 46 CFR 111.70-5 - Heater circuits.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Heater circuits. 111.70-5 Section 111.70-5 Shipping... REQUIREMENTS Motor Circuits, Controllers, and Protection § 111.70-5 Heater circuits. (a) If an enclosure for a... from a separate circuit, the heater circuit must be disconnected from its source of potential by...

  15. Materials for a Stirling engine heater head

    Science.gov (United States)

    Noble, J. E.; Lehmann, G. A.; Emigh, S. G.

    1990-01-01

    Work done on the 25-kW advanced Stirling conversion system (ASCS) terrestrial solar program in establishing criteria and selecting materials for the engine heater head and heater tubes is described. Various mechanisms contributing to incompatibility between materials are identified and discussed. Large thermal gradients, coupled with requirements for long life (60,000 h at temperature) and a large number of heatup and cooldown cycles (20,000) drive the design from a structural standpoint. The pressurized cylinder is checked for creep rupture, localized yielding, reverse plasticity, creep and fatigue damage, and creep ratcheting, in addition to the basic requirements for bust and proof pressure. In general, creep rupture and creep and fatigue interaction are the dominant factors in the design. A wide range of materials for the heater head and tubes was evaluated. Factors involved in the assessment were strength and effect on engine efficiency, reliability, and cost. A preliminary selection of Inconel 713LC for the heater head is based on acceptable structural properties but driven mainly by low cost. The criteria for failure, the structural analysis, and the material characteristics with basis for selection are discussed.

  16. Preparation of Pt/C Catalyst with Solid Phase Reaction Method

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    The Pt/C catalyst was prepared with solid phase reaction method (Pt/C(S)) for the first time. Its performances were compared with that prepared by the traditional liquid phase reaction method. The results demonstrate that the electrocatalytic activity of Pt/C catalyst with solid phase reaction method for methanol oxidation is higher than that with liquid phase reaction method. XRD and TEM measurements indicate that the Pt/C(S) possesses low crystalline extent and small particle size.

  17. Microbunching Instability Effect Studies and Laser Heater Optimization for the SPARX FEL Accelerator

    Energy Technology Data Exchange (ETDEWEB)

    Vaccarezza, C.; Chiadroni, E.; Ferrario, M.; Giannessi, L.; Quattromini, M.; Ronsivalle, C.; Venturini, C.; Migliorati, M.; Dattoli, G.

    2010-05-23

    The effects of microbunching instability for the SPARX accelerator have been analyzed by means of numerical simulations. The laser heater counteracting action has been addressed in order to optimize the parameters of the compression system, either hybrid RF plus magnetic chicane or only magnetic, and possibly enhance the FEL performance.

  18. Transcriptional control of Shh/Ptc1 signaling in embryonic development.

    Science.gov (United States)

    Lin, Shi-Lung; Chang, Shin-Ju E; Ying, Shao-Yao

    2006-02-15

    In vivo profiling of signal-directed gene expression patterns is a major bottleneck in studying developmental biology. A signal molecule initiates its specific gene expression pattern through the activation of certain transcription factor (TF); however, tissue heterogeneity often masks this pattern due to intercellular complexity of other signal transduction pathways. To decipher the synergistic regulation of signal-directed gene expression in the tissue level, we report here a unique transcriptional responsive element (TRE) existing in the 5'-upstream promoter regions (5'-UPR) of the genes responding to the Shh/Ptc1 signal transduction pathway during feather placode development in chicken embryos. By locating the TRE homologue and its interactive TF, we were able to reveal the gene expression pattern of the Shh/Ptc1 signaling. We firstly demonstrated that homology profiling of the 5'-UPR of the genes, Gli1, TGF-beta2 and Msx2, responding to the Shh/Ptc1 signaling showed a more than 70% conserved region. Computer alignment of the consensus sequences in the conserved region revealed a 37-nucleotide TRE sequence, containing two regulatory elements homologous to human and mouse Gli-binding sites. Activation of this newly identified Shh/Ptc1-responsive TRE by active Smo signaling in chicken hepatoepithelial carcinoma cells elicited a strong synergistic expression of the Shh/Ptc1-downstream genes. Based on previous bioinformatics and the present experimental findings, we successfully established an in vivo signaling model for the Shh/Ptc1-directed embryonic feather morphogenesis.

  19. Sunitinib inhibits papillary thyroid carcinoma with RET/PTC rearrangement but not BRAF mutation.

    Science.gov (United States)

    Jeong, Woo-Jin; Mo, Ji-Hun; Park, Min Woo; Choi, Ik Joon; An, Soo-Youn; Jeon, Eun-Hee; Ahn, Soon-Hyun

    2011-09-01

    Sunitinib, a multi-targeted tyrosine kinase inhibitor, is frequently incorporated into the management of papillary thyroid carcinoma refractory to standard therapies. Although clinical trials are in progress, the mechanism of action in papillary thyroid carcinomas is not clear, especially regarding the effect on BRAF mutation. We investigated the effect of sunitinib on papillary thyroid carcinoma cells harboring RET/PTC rearrangement and BRAF mutation using TPC-1M, SNU-790, and B-cPAP cell lines. Cell growth of papillary thyroid cancer cells with RET/PTC rearrangement was effectively inhibited at low doses of sunitinib (IC50=0.658 μM), whereas that of BRAF mutated cells required higher doses. Immunoblotting revealed effective blocking of MEK/ERK pathway in RET/PTC rearrangement cells, but not in BRAF mutated cells. Cell cycle analysis showed G1 arrest in RET/PTC rearrangement cells. In vivo orthotopic thyroid cancer mouse model demonstrated statistically significant tumor growth inhibition by sunitinib in RET/PTC rearrangement cancer cells. We conclude that sunitinib effectively inhibits RET/PTC rearrangement cells but not BRAF mutated cells. These data suggest that sunitinib exerts its effect by inhibiting the upstream MAPK signaling cascade. These findings support the unsatisfactory treatment outcomes of sunitinib in many already ongoing clinical trials compared to other tyrosine kinase inhibitors. Clinical application of sunitinib should be directed accordingly.

  20. Analysis Approach to Improve Star Rating Of Water Heater

    Directory of Open Access Journals (Sweden)

    Sujata Dabhade

    2014-07-01

    Full Text Available Electric Water Heaters are widely used all over the world that can be categorized in two types i.e. Instant Water Heaters & Storage type Water Heaters. The energy consumption for 6 liter water heaters is much higher in the storage type of water heater. As energy is an important factor for economic development of country, therefore there is need to save the energy which implies the focus to use Storage type Water Heaters. In 6 Liter water heater, Existing model converting from 4 star rating to 5 star rating by thermal analysis & insulation. After the theoretical calculation of thickness of glass wool is the practical testing of product with BEE norms & got results for 5 Star Calculation. Finally we are doing the thermal analysis for theoretical & practical verification of the product

  1. Insights into the binding of Phenyltiocarbamide (PTC agonist to its target human TAS2R38 bitter receptor.

    Directory of Open Access Journals (Sweden)

    Xevi Biarnés

    Full Text Available Humans' bitter taste perception is mediated by the hTAS2R subfamily of the G protein-coupled membrane receptors (GPCRs. Structural information on these receptors is currently limited. Here we identify residues involved in the binding of phenylthiocarbamide (PTC and in receptor activation in one of the most widely studied hTAS2Rs (hTAS2R38 by means of structural bioinformatics and molecular docking. The predictions are validated by site-directed mutagenesis experiments that involve specific residues located in the putative binding site and trans-membrane (TM helices 6 and 7 putatively involved in receptor activation. Based on our measurements, we suggest that (i residue N103 participates actively in PTC binding, in line with previous computational studies. (ii W99, M100 and S259 contribute to define the size and shape of the binding cavity. (iii W99 and M100, along with F255 and V296, play a key role for receptor activation, providing insights on bitter taste receptor activation not emerging from the previously reported computational models.

  2. Insights into the binding of Phenyltiocarbamide (PTC) agonist to its target human TAS2R38 bitter receptor.

    Science.gov (United States)

    Biarnés, Xevi; Marchiori, Alessandro; Giorgetti, Alejandro; Lanzara, Carmela; Gasparini, Paolo; Carloni, Paolo; Born, Stephan; Brockhoff, Anne; Behrens, Maik; Meyerhof, Wolfgang

    2010-08-25

    Humans' bitter taste perception is mediated by the hTAS2R subfamily of the G protein-coupled membrane receptors (GPCRs). Structural information on these receptors is currently limited. Here we identify residues involved in the binding of phenylthiocarbamide (PTC) and in receptor activation in one of the most widely studied hTAS2Rs (hTAS2R38) by means of structural bioinformatics and molecular docking. The predictions are validated by site-directed mutagenesis experiments that involve specific residues located in the putative binding site and trans-membrane (TM) helices 6 and 7 putatively involved in receptor activation. Based on our measurements, we suggest that (i) residue N103 participates actively in PTC binding, in line with previous computational studies. (ii) W99, M100 and S259 contribute to define the size and shape of the binding cavity. (iii) W99 and M100, along with F255 and V296, play a key role for receptor activation, providing insights on bitter taste receptor activation not emerging from the previously reported computational models.

  3. Expressions of miRNAs in papillary thyroid carcinoma and their associations with the clinical characteristics of PTC.

    Science.gov (United States)

    Hu, Jianxia; Li, Chengqian; Liu, Chongkai; Zhao, Shihua; Wang, Yangang; Fu, Zhengju

    2017-01-01

    The sensitivity and specificity of biomarkers which have been used in clinical practice for diagnosis of papillary thyroid carcinoma (PTC) are low, it is essential to develop novel diagnostic and prognostic biomarkers for PTC. To explore the expressions of miR-940, miR-15a, miR-16 and IL-23 in PTC tissues and plasma and their associations with the clinical characteristics of PTC. We investigated the expressions of miR-940, miR-15a, miR-16 and IL-23 in plasma and thyroid tissues of PTC, nodular goiter and healthy people with qRT-PCR, and further analyzed the associations between their levels and the clinical characteristics of PTC. Level of IL-23 expression was higher while levels of miR-940, miR-15a and miR-16 expression in the PTC tissues were lower compared with the nodular goiter tissues and perineoplastic thyroid tissues. And the levels of miR-940, miR-15a, miR-16 and IL-23 expression in the PTC tissues were associated with some clinical characteristics of PTC, including bilateral tumor, multicentricity, extrallyroidal invasion, cervical lymph node metastasis, distant metastasis and clinical advanced stages (III/IV). Expressions of miR-940, miR-15a, miR-16 and IL-23 in PTC tissues might be useful biomarkers and promising targets in the diagnosis of papillary thyroid carcinoma.

  4. Association of TERT Promoter Mutation, But Not BRAF Mutation, With Increased Mortality in PTC.

    Science.gov (United States)

    George, Jonathan R; Henderson, Ying C; Williams, Michelle D; Roberts, Dianna B; Hei, Hu; Lai, Stephen Y; Clayman, Gary L

    2015-12-01

    Papillary thyroid carcinoma (PTC) carrying the BRAF mutation has been reported to be associated with high recurrence and potentially increased mortality. PTC carrying the TERT promoter mutation has been associated with older age, recurrence, and aggressive disease. The objective of this study was to determine the association of BRAF and TERT promoter gene alterations with recurrence and survival in a high-risk population. Genomic DNA was analyzed for the BRAF mutation from 256 persistent/recurrent PTC (p/rPTC; 202 new, 54 previously reported) and for the TERT promoter mutation and polymorphism (242 p/rPTC). Two-tailed Fisher exact tests or the Pearson χ(2) test were performed for the associations between mutations and other variables. Overall and disease-free survivals were compared by log rank tests on Kaplan-Meier plots and by Cox regression analysis. TERT promoter constructs were tested in PTC cell lines to determine their activities in these cells. BRAF V600E mutation was identified in 235 of 256 (91.8%), TERT promoter mutation at -124 was detected in 77 of 242 (31.8%), and TERT promoter polymorphism at -245 was found in 113 of 242 (46.7%) p/rPTC patients. A significant difference in survival was found in p/rPTC patients with the TERT promoter mutation, which also displayed increased activity in vitro as compared to the nonmutated promoter sequence. No association was noted between the BRAF mutation or TERT promoter polymorphism and recurrence or survival. A drawback of our study could be the limited number of patients with nonmutated BRAF (21 of 256 [8.2%]). Mutation in the TERT promoter, but not in BRAF, was associated with decreased survival in 19 (24.7%) p/rPTC patients who died of disease and in 38 (49.4%) p/rPTC patients who died at last contact. The presence or absence of the BRAF mutation and TERT promoter polymorphism, however, was not significantly correlated with survival.

  5. Type 2C protein phosphatase Ptc6 participates in activation of the Slt2-mediated cell wall integrity pathway in Saccharomyces cerevisiae.

    Science.gov (United States)

    Sharmin, Dilruba; Sasano, Yu; Sugiyama, Minetaka; Harashima, Satoshi

    2015-04-01

    The phosphorylation status of cellular proteins results from an equilibrium between the activities of protein kinases and protein phosphatases (PPases). Reversible protein phosphorylation is an important aspect of signal transduction that regulate many biological processes in eukaryotic cells. The Saccharomyces cerevisiae genome encodes 40 PPases, including seven members of the protein phosphatase 2C subfamily (PTC1 to PTC7). In contrast to other PPases, the cellular roles of PTCs have not been investigated in detail. Here, we sought to determine the cellular role of PTC6 in S. cerevisiae with disruption of PTC genes. We found that cells with Δptc6 disruption were tolerant to the cell wall-damaging agents Congo red (CR) and calcofluor white (CFW); however, cells with simultaneous disruption of PTC1 and PTC6 were very sensitive to these agents. Thus, simultaneous disruption of PTC1 and PTC6 gave a synergistic response to cell wall damaging agents. The level of phosphorylated Slt2 increased significantly after CR treatment in Δptc1 cells and more so in Δptcptc6 cells; therefore, deletion of PTC6 enhanced Slt2 phosphorylation in the Δptc1 disruptant. The level of transcription of KDX1 upon exposure to CR increased to a greater extent in the Δptcptc6 double disruptant than the Δptc1 single disruptant. The Δptcptc6 double disruptant cells showed normal vacuole formation under standard growth conditions, but fragmented vacuoles were present in the presence of CR or CFW. Our analyses indicate that S. cerevisiae PTC6 participates in the negative regulation of Slt2 phosphorylation and vacuole morphogenesis under cell wall stress conditions.

  6. Solar Air Heaters with Thermal Heat Storages

    Directory of Open Access Journals (Sweden)

    Abhishek Saxena

    2013-01-01

    Full Text Available Solar energy can be converted into different forms of energy, either to thermal energy or to electrical energy. Solar energy is converted directly into electrical power by photovoltaic modules, while solar collector converts solar energy into thermal energy. Solar collector works by absorbing the direct solar radiation and converting it into thermal energy, which can be stored in the form of sensible heat or latent heat or a combination of sensible and latent heats. A theoretical study has been carried out to rate the various thermal energy storage commonly used in solar air heaters. During the investigations rock bed storages have been found to be low type thermal heat storage, while phase change materials have been found to be high heat thermal storages. Besides this, a few other heat storing materials have been studied and discussed for lower to higher ratings in terms of thermal performance purposely for solar heaters.

  7. Improving the Gas Instantaneous Water Heaters Performances

    Directory of Open Access Journals (Sweden)

    Nasir Kloub

    2005-01-01

    Full Text Available This study presents a study of a theoretical and practical investigation of the gas Instantaneous (Tankless water Heaters performance. The results allow us to obtain realistic values of the control system in the various capacities gaseous flowing water heaters. The objective of this work is to study the operation of the plans in the field of controlling and checking low capacity gaseous flowing water in order to choose the proper plan of the logical values and measures for these equipments that may be used in industrial conditions. Also results of the work proved to be accurate. A design of the control system was made. The results of the practical experiment of the control system were similar to the arithmetic results.

  8. Single-heater test final report

    Energy Technology Data Exchange (ETDEWEB)

    Blair, S. C.; Buscheck, T. A.; DeLoach, L. D.; Lin, W.; Ramirez, A. I.

    1998-09-01

    The Single-Heater Test (SHT) was one phase of the field-scale thermal testing program of the Yucca Mountain Site Characterization Project. The primary purpose of the SHT was to study the thermomechanical (TM) behavior of the densely welded, non-lithophysal Topopah Spring tuff at the Exploratory Studies Facility. The SHT was also used as a shake-down for testing thermal-hydrologic-chemical-mechanical processes in situ, testing that will be conducted in the Drift-Scale Test. In the SHT, a line-heat source 5-m long was emplaced in a pillar and used to heat the pillar for approximately nine months. The thermal field was relatively cylindrical about the line-heat source. The heater was turned off after nine months of heating, and the rock mass was monitored during the cool-down for another nine months, until May 28, 1997, when the test was terminated.

  9. Solar water heater for NASA's Space Station

    Science.gov (United States)

    Somers, Richard E.; Haynes, R. Daniel

    1988-01-01

    The feasibility of using a solar water heater for NASA's Space Station is investigated using computer codes developed to model the Space Station configuration, orbit, and heating systems. Numerous orbit variations, system options, and geometries for the collector were analyzed. Results show that a solar water heater, which would provide 100 percent of the design heating load and would not impose a significant impact on the Space Station overall design is feasible. A heat pipe or pumped fluid radial plate collector of about 10-sq m, placed on top of the habitat module was found to be well suited for satisfying water demand of the Space Station. Due to the relatively small area required by a radial plate, a concentrator is unnecessary. The system would use only 7 to 10 percent as much electricity as an electric water-heating system.

  10. AWSWAH - the heat pipe solar water heater

    Energy Technology Data Exchange (ETDEWEB)

    Akyurt, M.

    1986-01-01

    An all weather heat pipe solar water heater (AWSWAH) comprising a collector of 4 m/sup 2/ (43 ft/sup 2/) and a low profile water tank of 160 liters (42 gal.) was developed. A single heat pipe consisting of 30 risers and two manifolds in the evaporator and a spiral condenser was incorporated into the AWSWAH. Condensate metering was done by synthetic fiber wicks. The AWSWAH was tested alongside two conventional solar water heaters of identical dimensions, an open loop system and a closed loop system. It was found that the AWSWAH was an average of 50% more effective than the open system in the temperature range 30-90 /sup 0/C (86-194 /sup 0/F). The closed loop system was the least efficient of the three systems.

  11. Water loss from the skin of term and preterm infants nursed under a radiant heater.

    Science.gov (United States)

    Kjartansson, S; Arsan, S; Hammarlund, K; Sjörs, G; Sedin, G

    1995-02-01

    The rate of evaporation from the skin (g/m2/h) was measured in 12 full-term and 16 preterm infants (gestational age 25-34 wk) both during incubator care and when nursed under a radiant heater. The method for evaporation rate measurement is noninvasive and based on determination of the water vapor pressure gradient close to the skin surface. Measurements were first made with the infant nursed in an incubator with a controlled environment with respect to humidity, temperature, and air velocity. The measurements in the term infants were performed at an ambient relative humidity (RH) of 50%, and in the preterm infants first at 50% and subsequently at 30-40%. Evaporation rate was then measured with the infant nursed under a radiant heater. In term infants, mean evaporation rate was 3.3 g/m2/h during incubator care (RH 50%) and 4.4 g/m2/h during care under the radiant heater. In preterm infants, the corresponding values were 15.5 g/m2/h in the incubator at RH 50%, 16.7 g/m2/h at RH 30-40%, and 17.9 g/m2/h under the radiant heater. It is concluded that the evaporative water loss from the skin depends on the ambient water vapor pressure, irrespective of whether the infant is nursed in an incubator or under a radiant heater. The higher rate of evaporation during care under a radiant heater is due to the lower ambient water vapor pressure and not to any direct effect of the nonionizing radiation on the skin.

  12. Firebox modeling of SRT cracking heaters

    Energy Technology Data Exchange (ETDEWEB)

    Sundaram, K.M.; Albano, J.V. [ABB Lummus Crest Inc., Bloomfield, NJ (United States)

    1994-12-31

    Thermal cracking of hydrocarbons remains the most economically attractive route for the production of ethylene. The heat for the endothermic cracking reaction is supplied in high capacity fired heaters which are designed specifically to have high selectivity to olefins. In the cracking process, coke is deposited within the tubes of the radiant coil. The rate of coke deposition in a cracking furnace is a function not only of process conditions but of other factors as well. High tube metal temperatures in certain areas of the coil or hot spots can cause locally high coking rate leading to partial blockage of the tubes and consequently, short runs. The small diameter tubes used in modern high selectivity heaters are more sensitive than older large tube designs. The occurrence of these hot zones is a strong function of fireside conditions. For satisfactory performance, the heat flux profile in a cracking heater must be maintained as uniform as possible. In addition, it is important to minimize the variation of process temperatures entering the various cracking coils. These fireside variables are not only a function of the type of burners, excess air, type of fuel(s) and distribution of air and fuel but depend significantly on the air and flue gas flow patterns associated with the firebox, i.e., the firebox aerodynamics. Poor aerodynamics can adversely affect firing patterns and hence heat flux profiles in commercial furnaces. A variety of modeling techniques have been used to evaluate the firebox aerodynamics of Lummus, Short Residence Time, cracking heaters. These include flow visualization, physical cold flow modeling, and computational techniques. These approaches are discussed in this paper.

  13. Field Monitoring Protocol: Heat Pump Water Heaters

    Energy Technology Data Exchange (ETDEWEB)

    Sparn, B.; Earle, L.; Christensen, D.; Maguire, J.; Wilson, E.; Hancock, E.

    2013-02-01

    This document provides a standard field monitoring protocol for evaluating the installed performance of Heat Pump Water Heaters in residential buildings. The report is organized to be consistent with the chronology of field test planning and execution. Research questions are identified first, followed by a discussion of analysis methods, and then the details of measuring the required information are laid out. A field validation of the protocol at a house near the NREL campus is included for reference.

  14. Field Monitoring Protocol. Heat Pump Water Heaters

    Energy Technology Data Exchange (ETDEWEB)

    Sparn, B. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Earle, L. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Christensen, D. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Maguire, J. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Wilson, E. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Hancock, C. E. [Mountain Energy Partnership, Longmont, CO (United States)

    2013-02-01

    This document provides a standard field monitoring protocol for evaluating the installed performance of Heat Pump Water Heaters in residential buildings. The report is organized to be consistent with the chronology of field test planning and execution. Research questions are identified first, followed by a discussion of analysis methods, and then the details of measuring the required information are laid out. A field validation of the protocol at a house near the NREL campus is included for reference.

  15. Molecular basis for the high-affinity binding and stabilization of firefly luciferase by PTC124

    Energy Technology Data Exchange (ETDEWEB)

    Auld, Douglas S.; Lovell, Scott; Thorne, Natasha; Lea, Wendy A.; Maloney, David J.; Shen, Min; Rai, Ganesha; Battaile, Kevin P.; Thomas, Craig J.; Simeonov, Anton; Hanzlik, Robert P.; Inglese, James (NIH); (Kansas); (HWMRI)

    2010-04-07

    Firefly luciferase (FLuc), an ATP-dependent bioluminescent reporter enzyme, is broadly used in chemical biology and drug discovery assays. PTC124 Ataluren; (3-[5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl]benzoic acid) discovered in an FLuc-based assay targeting nonsense codon suppression, is an unusually potent FLuc-inhibitor. Paradoxically, PTC124 and related analogs increase cellular FLuc activity levels by posttranslational stabilization. In this study, we show that FLuc inhibition and stabilization is the result of an inhibitory product formed during the FLuc-catalyzed reaction between its natural substrate, ATP, and PTC124. A 2.0 {angstrom} cocrystal structure revealed the inhibitor to be the acyl-AMP mixed-anhydride adduct PTC124-AMP, which was subsequently synthesized and shown to be a high-affinity multisubstrate adduct inhibitor (MAI; KD = 120 pM) of FLuc. Biochemical assays, liquid chromatography/mass spectrometry, and near-attack conformer modeling demonstrate that formation of this novel MAI is absolutely dependent upon the precise positioning and reactivity of a key meta-carboxylate of PTC124 within the FLuc active site. We also demonstrate that the inhibitory activity of PTC124-AMP is relieved by free coenzyme A, a component present at high concentrations in luciferase detection reagents used for cell-based assays. This explains why PTC124 can appear to increase, instead of inhibit, FLuc activity in cell-based reporter gene assays. To our knowledge, this is an unusual example in which the 'off-target' effect of a small molecule is mediated by an MAI mechanism.

  16. Molecular basis for the high-affinity binding and stabilization of firefly luciferase by PTC124

    Science.gov (United States)

    Auld, Douglas S.; Lovell, Scott; Thorne, Natasha; Lea, Wendy A.; Maloney, David J.; Shen, Min; Rai, Ganesha; Battaile, Kevin P.; Thomas, Craig J.; Simeonov, Anton; Hanzlik, Robert P.; Inglese, James

    2010-01-01

    Firefly luciferase (FLuc), an ATP-dependent bioluminescent reporter enzyme, is broadly used in chemical biology and drug discovery assays. PTC124 (Ataluren; (3-[5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl]benzoic acid) discovered in an FLuc-based assay targeting nonsense codon suppression, is an unusually potent FLuc-inhibitor. Paradoxically, PTC124 and related analogs increase cellular FLuc activity levels by posttranslational stabilization. In this study, we show that FLuc inhibition and stabilization is the result of an inhibitory product formed during the FLuc-catalyzed reaction between its natural substrate, ATP, and PTC124. A 2.0 Å cocrystal structure revealed the inhibitor to be the acyl-AMP mixed-anhydride adduct PTC124-AMP, which was subsequently synthesized and shown to be a high-affinity multisubstrate adduct inhibitor (MAI; KD = 120 pM) of FLuc. Biochemical assays, liquid chromatography/mass spectrometry, and near-attack conformer modeling demonstrate that formation of this novel MAI is absolutely dependent upon the precise positioning and reactivity of a key meta-carboxylate of PTC124 within the FLuc active site. We also demonstrate that the inhibitory activity of PTC124-AMP is relieved by free coenzyme A, a component present at high concentrations in luciferase detection reagents used for cell-based assays. This explains why PTC124 can appear to increase, instead of inhibit, FLuc activity in cell-based reporter gene assays. To our knowledge, this is an unusual example in which the “off-target” effect of a small molecule is mediated by an MAI mechanism. PMID:20194791

  17. Heater Validation for the NEXT-C Hollow Cathodes

    Science.gov (United States)

    Verhey, Timothy R.; Soulas, George C.; Mackey, Jonathan Ar.

    2017-01-01

    Swaged cathode heaters whose design was successfully demonstrated under a prior flight project are to be provided by the NASA Glenn Research Center for the NEXT-C ion thruster being fabricated by Aerojet Rocketdyne. Extensive requalification activities were performed to validate process controls that had to be re-established or revised because systemic changes prevented reuse of the past approaches. A development batch of heaters was successfully fabricated based on the new process controls. Acceptance and cyclic life testing of multiple discharge and neutralizer sized heaters extracted from the development batch was initiated in August, 2016, with the last heater completing testing in April, 2017. Cyclic life testing results substantially exceeded the NEXT-C thruster requirement as well as all past experience for GRC fabricated units. The heaters demonstrated ultimate cyclic life capability of 19050 to 33500 cycles. A qualification batch of heaters is now being fabricated using the finalized process controls. A set of six heaters will be acceptance and cyclic tested to verify conformance to the behavior observed with the development heaters. The heaters for flight use will be then be provided to the contractor. This paper summarizes the fabrication process control activities and the acceptance and life testing of the development heater units.

  18. Sources of nitrogen dioxide (NO2) in New Zealand homes: findings from a community randomized controlled trial of heater substitutions.

    Science.gov (United States)

    Gillespie-Bennett, J; Pierse, N; Wickens, K; Crane, J; Nicholls, S; Shields, D; Boulic, M; Viggers, H; Baker, M; Woodward, A; Howden-Chapman, P

    2008-12-01

    Houses in New Zealand have inadequate space heating and a third of households use unflued gas heaters. As part of a large community intervention trial to improve space heating, we replaced ineffective heaters with more effective, non-polluting heaters. This paper assesses the contribution of heating and household factors to indoor NO2 in almost 350 homes and reports on the reduction in NO2 levels due to heater replacement. Homes using unflued gas heaters had more than three times the level of NO2 in living rooms [geometric mean ratio (GMR) = 3.35, 95% CI: 2.83-3.96, P heaters, whereas homes using gas stove-tops had significantly elevated living room NO2 levels (GMR = 1.42, 95% CI: 1.05-1.93, P = 0.02). Homes with heat pumps, flued gas heating, or enclosed wood burners had significantly lower levels of NO2 in living areas and bedrooms. In homes that used unflued gas heaters as their main form of heating at baseline, the intervention was associated with a two-third (67%) reduction in NO2 levels in living rooms, when compared with homes that continued to use unflued gas heaters. Reducing the use of unflued gas heating would substantially lower NO2 exposure in New Zealand homes. Understanding the factors influencing indoor NO2 levels is critical for the assessment and control of indoor air pollution. This study found that homes that used unflued gas combustion appliances for heating and cooking had higher NO2 levels compared with homes where other fuels were used. These findings require institutional incentives to increase the use of more effective, less polluting fuels, particularly in the home environment.

  19. Characterization and vectorization of siRNA targeting RET/PTC1 in human papillary thyroid carcinoma cells

    Directory of Open Access Journals (Sweden)

    Massade L.

    2011-10-01

    Full Text Available RET/PTC1 fusion oncogene is the most common genetic alteration identified to date in thyroid papillary carcinomas (PTC and represents a good target for small interfering RNA (siRNA. Our aim was: i to target the RET/PTC1 oncogene by siRNAs, ii to assess the knockdown effects on cell growth and cell cycle regulation and iii to vectorize it in order to protect it from degradation. Methods. Human cell lines expressing RET/PTC1 were transfected by siRNA RET/PTC1, inhibition of the oncogene expression was assessed by qRT-PCR and by Western blot. Conjugation of siRNA RET/PTC1 to squalene was performed by coupling it to squalene. In vivo studies are performed in nude mice. Conclusion. In this short communication, we report the main published results obtained during last years.

  20. Structural and electronic properties of bulk and low-index surfaces of zincblende PtC

    Science.gov (United States)

    Gokhan Sensoy, Mehmet; Toffoli, Daniele; Ustunel, Hande

    2017-03-01

    Transition metal carbides have been extensively used in diverse applications over the past decade. Their versatility is in part thanks to their unique bonding, which displays a mixture of ionic, metallic and covalent character. While the bulk structure of zincblende (ZB) PtC has been investigated several times, a detailed understanding of the electronic and structural properties of its low-index surfaces is lacking. In this work, we present an ab initio investigation of the properties of five crystallographic ZB PtC surfaces (Pt/C-terminated PtC(1 0 0), PtC(1 1 0) and Pt/C-terminated PtC(1 1 1)). Upon geometry optimization, both polar and nonpolar surfaces undergo a mild interlayer relaxation, without extensive reconstructions. Calculated vacancy formation energies indicate facile C removal on the (1 1 1) surface while Pt-vacancy formation is endothermic. Finally, atomic O adsorption energies on all surfaces reveal a high affinity of the C-terminated surfaces towards this species.

  1. Activity improvement of Pt/C catalysts by adding CeO2 nanoparticles

    Institute of Scientific and Technical Information of China (English)

    YANG Yuying; ZHANG Ziyu; HU Zhongai

    2011-01-01

    Carbon-supported platinum catalysts were prepared by NaBH4 reduction of metal precursors and the CeO2 nanoparticles were prepared by citric acid sol-gel method. The structure and morphology of two kinds of nanoparticles were characterized by X-ray diffraction (XRD) and transmission electron microscopy (TEM), respectively. The Pt particles were uniformly dispersed on the carbon surface and showed the rod-like morphology. The CeO2 was spherical in shape. The appropriate amount of CeO2 nanoparticles was added into Pt/C systems to improve activity of the catalysts. Several electrochemical techniques such as cyclic voltammogram (CV), chronoamperometry (I-t)and electrochemical impedance spectroscopy (EIS) were used to investigate the properties of CeO2-Pt/C catalysts for methanol electrooxidation in 1 mol/L CH3OH+0.5H2SO4 aqueous solutions. The results revealed that compared with Pt/C catalysts CeO2-pt/C exhibited a higher activity and stability for methanol electro-oxidation. Moreover, the effect of CeO2 content on the activity of Pt/C catalysts was discussed in detail.

  2. Evaluation of Annual Modis Ptc Data for Deforestation and Forest Degradation Analysis

    Science.gov (United States)

    Gao, Y.; Ghilardi, A.; Mas, J. F.; Paneque-Galvez, J.; Skutsch, M.

    2016-06-01

    Anthropogenic land-cover change, e.g. deforestation and forest degradation cause carbon emissions. To estimate deforestation and forest degradation, it is important to have reliable data on forest cover. In this analysis, we evaluated annual MODIS Percent Tree Cover (PTC) data for the detection of forest change including deforestation, forest degradation, reforestation and revegetation. The annual MODIS PTC data (2000 - 2010) were pre-processed by applying quality layer. Based on the PTC values of the annual MODIS data, forest change maps were produced and assessed by comparing with the data from visual interpretation of SPOT-5 images. The assessment was applied to two case-studies: Ayuquila Basin and Monarch Reserve. Results show that the detected deforestation patches by visual interpretation are roughly 4 times in quantity more than those by MODIS PTC data, which can be partially due to the much higher spatial resolution of SPOT-5, being able to pick up small deforestation patches. This analysis found poor spatial overlapping for both case-studies. Possible reasons for the discrepancy in quantity and spatial coincidence were provided. It is necessary to refine the methodology for forest change detection by PTC images; also to refine the validation data in terms of data periods and forest change categories to ensure a better assessment.

  3. RET/PTC rearrangement is prevalent in follicular Hürthle cell carcinomas.

    Science.gov (United States)

    de Vries, Margriet M; Celestino, Ricardo; Castro, Patricia; Eloy, Catarina; Máximo, Valdemar; van der Wal, Jacqueline E; Plukker, John T M; Links, Thera P; Hofstra, Robert M W; Sobrinho-Simões, Manuel; Soares, Paula

    2012-11-01

    The molecular alterations underlying follicular Hürthle cell carcinomas (FHCCs) are largely unknown. In an attempt to clarify this issue, we analysed a series of Hürthle cell tumours for the presence of RET/PTC and PAX8/PPARG rearrangements and BRAF, HRAS and NRAS mutations. We investigated a series of 20 follicular Hürthle cell tumours [17 FHCCs and three follicular Hürthle cell adenomas (FHCAs)]. RET/PTC rearrangements were found in 33% of FHCAs and in 38% of FHCCs. All RET/PTC-positive FHCCs had a solid pattern of growth. PAX8/PPARG rearrangement was present in 27% of the FHCCs which displayed, in most cases, a follicular architecture. NRAS mutation was detected in one FHCC. An FHCC with a solid/microfollicular growth pattern scored positive for both RET/PTC and PAX8/PPARG rearrangement. Our study has shown a significant association between RET/PTC rearrangements and FHCCs with a solid growth pattern, thus raising the possibility of using tyrosine kinase inhibitors for the treatment of patients with FHCCs, which are often refractory to radioiodine treatment. © 2012 Blackwell Publishing Limited.

  4. Structural and electronic properties of bulk and low-index surfaces of zincblende PtC.

    Science.gov (United States)

    Sensoy, Mehmet Gokhan; Toffoli, Daniele; Ustunel, Hande

    2017-03-29

    Transition metal carbides have been extensively used in diverse applications over the past decade. Their versatility is in part thanks to their unique bonding, which displays a mixture of ionic, metallic and covalent character. While the bulk structure of zincblende (ZB) PtC has been investigated several times, a detailed understanding of the electronic and structural properties of its low-index surfaces is lacking. In this work, we present an ab initio investigation of the properties of five crystallographic ZB PtC surfaces (Pt/C-terminated PtC(1 0 0), PtC(1 1 0) and Pt/C-terminated PtC(1 1 1)). Upon geometry optimization, both polar and nonpolar surfaces undergo a mild interlayer relaxation, without extensive reconstructions. Calculated vacancy formation energies indicate facile C removal on the (1 1 1) surface while Pt-vacancy formation is endothermic. Finally, atomic O adsorption energies on all surfaces reveal a high affinity of the C-terminated surfaces towards this species.

  5. A novel RET/PTC variant detected in a pediatric patient with papillary thyroid cancer without ionization history.

    Science.gov (United States)

    Halkova, Tereza; Dvorakova, Sarka; Vaclavikova, Eliska; Sykorova, Vlasta; Vcelak, Josef; Sykorova, Pavla; Vlcek, Petr; Reboun, Martin; Katra, Rami; Kodetova, Daniela; Schrumpf, Melanie; van Wezel, Tom; Morreau, Hans; Bendlova, Bela

    2015-12-01

    Papillary thyroid carcinoma (PTC) is the most frequent type of thyroid cancer. Its development is often caused by the formation of RET/PTC fused genes. RET/PTC1 is the most prevalent form, where exon 1 of CCDC6 gene is fused with the intracellular portion of RET protooncogene starting with exon 12. We have discovered a novel RET/PTC1 variant which we have named RET/PTC1ex9 in metastatic PTC of 8-year-old boy. RET/PTC1ex9 detection was performed by real-time polymerase chain reaction with melting curve analysis and subsequent Sanger and next-generation sequencing. A fusion of exon 1 of CCDC6 with exon 9 of extracellular domain of RET followed by exon 12 of RET was revealed. This is the first RET/PTC variant among PTC cases that contain the extracellular part of RET. This observation could be probably explained by incorrect splicing of RET due to the somatic 32-bp deletion in exon-intron 11 boundary of RET. Copyright © 2015 Elsevier Inc. All rights reserved.

  6. Insulated conductor temperature limited heater for subsurface heating coupled in a three-phase WYE configuration

    Energy Technology Data Exchange (ETDEWEB)

    Vinegar, Harold J. (Bellaire, TX); Sandberg, Chester Ledlie (Palo Alto, CA)

    2010-11-09

    A heating system for a subsurface formation is described. The heating system includes a first heater, a second heater, and a third heater placed in an opening in the subsurface formation. Each heater includes: an electrical conductor; an insulation layer at least partially surrounding the electrical conductor; and an electrically conductive sheath at least partially surrounding the insulation layer. The electrical conductor is electrically coupled to the sheath at a lower end portion of the heater. The lower end portion is the portion of the heater distal from a surface of the opening. The first heater, the second heater, and the third heater are electrically coupled at the lower end portions of the heaters. The first heater, the second heater, and the third heater are configured to be electrically coupled in a three-phase wye configuration.

  7. Impact of kerosene space heaters on indoor air quality.

    Science.gov (United States)

    Hanoune, B; Carteret, M

    2015-09-01

    In recent years, the use of kerosene space heaters as additional or principal heat source has been increasing, because these heaters allow a continuous control on the energy cost. These devices are unvented, and all combustion products are released into the room where the heaters are operated. The indoor air quality of seven private homes using wick-type or electronic injection-type kerosene space heaters was investigated. Concentrations of CO, CO2, NOx, formaldehyde and particulate matter (0.02-10 μm) were measured, using time-resolved instruments when available. All heaters tested are significant sources of submicron particles, NOx and CO2. The average NO2 and CO2 concentrations are determined by the duration of use of the kerosene heaters. These results stress the need to regulate the use of unvented combustion appliances to decrease the exposure of people to air contaminants. Copyright © 2014 Elsevier Ltd. All rights reserved.

  8. FEM Optimal Design of Wind Energy-based Heater

    Directory of Open Access Journals (Sweden)

    Tiberiu Tudorache

    2009-07-01

    Full Text Available This paper deals with the finite element based optimal design of a wind energybased heater. The proposed device ensures the conversion of the wind kinetic energy intoheat by means of Joule effect of eddy currents induced in the wall of a tubular stator due tothe rotating magnetic field produced by rotor permanent magnets. The transientelectromagnetic field problem associated to the operation of the device is solved using a2D finite element approach based on vector potential formulation. A simplified method forthe 2D heat transfer analysis of the device is also proposed. The influence of stator wallmaterial and thickness, number of poles, the airgap thickness and the geometricalparameters of the permanent magnets is analyzed in the aim of optimizing the studiedheater.

  9. Design of a Low-Frequency Oscillator with PTC Memristor and an Inductor

    Science.gov (United States)

    Rajamani, Vetriveeran; Yang, Changju; Kim, Hyongsuk; Chua, Leon

    An electronic oscillator circuit is designed by connecting an inductor in series with a locally-active PTC Memristor and a battery. The PTC Memristor is locally active on the negative resistance region of its DC VM-IM curve. A DC operating point Q is chosen on the locally-active region of the PTC Memristor and a small-signal equivalent circuit at Q is derived via Taylor series. The small-signal admittance YCM(s; V ) of the composite one-port in Fig. 1 is derived using the small-signal equivalent circuit at Q, in series with an inductor whose value is chosen such that YCM(iω0; V ) = 0 at some s = iω0. The sinusoidal oscillation computed numerically from this circuit is shown to emerge from a supercritical Hopf bifurcation.

  10. Multiplex minisequencing screening for PTC genotype associated with bitter taste perception.

    Science.gov (United States)

    Sagong, Borum; Bae, Jae Woong; Rhyu, Mee Ra; Kim, Un-Kyung; Ye, Mi-Kyung

    2014-03-01

    Sensitivity to phenylthiocarbamide (PTC) has a bimodal distribution pattern and the genotype of the TAS2R38 gene, which is composed of combinations of three coding single nucleotide polymorphisms (SNPs), p.A49P (c.145G>C), p.V262A (c.785T>C) and p.I296 V (c.886A>G), determines the ability or inability to taste PTC. In this study, we developed a tool for genotyping of these SNPs in the TAS2R38 gene using SNaPshot minisequencing and investigated the accuracy of the tool in 100 subjects who were genotyped by Sanger sequencing. The minor allele frequencies of the three SNPs were 0.39, and these genotypes corresponded to those determined by direct sequencing. In conclusion, we successfully developed a precise and rapid genetic tool for analysis of PTC genotype associated with bitter taste perception.

  11. Measure Guideline: Transitioning to a Tankless Water Heater

    Energy Technology Data Exchange (ETDEWEB)

    Brozyna, K.; Rapport, A.

    2012-09-01

    This Measure Guideline provides information to help residential builders and retrofitters with the design, specification, selection, implementation, installation, and maintenance issues of transitioning from tank-type water heaters to tankless water heaters. The report compares the differences between tankless and tank-type water heaters, highlighting the energy savings that can be realized by adopting tankless water heaters over tank-type water heaters. Selection criteria and risks discussed include unit sizing and location, water distribution system, plumbing line length and diameter, water quality, electrical backup, and code issues. Cost and performance data are provided for various types of tankless and tank-type water heaters, both natural gas fired and electric. Also considered are interactions between the tankless water heater and other functional elements of a house, such as cold water supply and low-flow devices. Operating costs and energy use of water distribution systems for single- and two-story houses are provided, along with discussion of the various types of distribution systems that can be used with tankless water heaters. Finally, details to prepare for proper installation of a tankless water heater are described.

  12. Field Performance of Heat Pump Water Heaters in the Northeast

    Energy Technology Data Exchange (ETDEWEB)

    Shapiro, Carl [Consortium for Advanced Residential Buildings, Norwalk, CT (United States); Puttagunta, Srikanth [Consortium for Advanced Residential Buildings, Norwalk, CT (United States)

    2016-02-01

    Heat pump water heaters (HPWHs) are finally entering the mainstream residential water heater market. Potential catalysts are increased consumer demand for higher energy efficiency electric water heating and a new Federal water heating standard that effectively mandates use of HPWHs for electric storage water heaters with nominal capacities greater than 55 gallons. When compared to electric resistance water heating, the energy and cost savings potential of HPWHs is tremendous. Converting all electric resistance water heaters to HPWHs could save American consumers 7.8 billion dollars annually ($182 per household) in water heating operating costs and cut annual residential source energy consumption for water heating by 0.70 quads.

  13. Assessing RET/PTC in thyroid nodule fine-needle aspirates: the FISH point of view.

    Science.gov (United States)

    Caria, Paola; Dettori, Tinuccia; Frau, Daniela V; Borghero, Angela; Cappai, Antonello; Riola, Alessia; Lai, Maria L; Boi, Francesco; Calò, Piergiorgio; Nicolosi, Angelo; Mariotti, Stefano; Vanni, Roberta

    2013-08-01

    RET/PTC rearrangement and BRAF(V600E) mutation are the two prevalent molecular alterations associated with papillary thyroid carcinoma (PTC), and their identification is increasingly being used as an adjunct to cytology in diagnosing PTC. However, there are caveats associated with the use of the molecular approach in fine-needle aspiration (FNA), particularly for RET/PTC, that should be taken into consideration. It has been claimed that a clonal or sporadic presence of this abnormality in follicular cells can distinguish between malignant and benign nodules. Nevertheless, the most commonly used PCR-based techniques lack the capacity to quantify the number of abnormal cells. Because fluorescence in situ hybridization (FISH) is the most sensitive method for detecting gene rearrangement in a single cell, we compared results from FISH and conventional RT-PCR obtained in FNA of a large cohort of consecutive patients with suspicious nodules and investigated the feasibility of setting a FISH-FNA threshold capable of distinguishing non-clonal from clonal molecular events. For this purpose, a home brew break-apart probe, able to recognize the physical breakage of RET, was designed. While a ≥3% FISH signal for broken RET was sufficient to distinguish nodules with abnormal follicular cells, only samples with a ≥6.8% break-apart FISH signal also exhibited positive RT-PCR results. On histological analysis, all nodules meeting the ≥6.8% threshold proved to be malignant. These data corroborate the power of FISH when compared with RT-PCR in quantifying the presence of RET/PTC in FNA and validate the RT-PCR efficiency in detecting clonal RET/PTC alterations.

  14. Enhancement of premature stop codon readthrough in the CFTR gene by Ataluren (PTC124) derivatives.

    Science.gov (United States)

    Pibiri, Ivana; Lentini, Laura; Melfi, Raffaella; Gallucci, Giulia; Pace, Andrea; Spinello, Angelo; Barone, Giampaolo; Di Leonardo, Aldo

    2015-08-28

    Premature stop codons are the result of nonsense mutations occurring within the coding sequence of a gene. These mutations lead to the synthesis of a truncated protein and are responsible for several genetic diseases. A potential pharmacological approach to treat these diseases is to promote the translational readthrough of premature stop codons by small molecules aiming to restore the full-length protein. The compound PTC124 (Ataluren) was reported to promote the readthrough of the premature UGA stop codon, although its activity was questioned. The potential interaction of PTC124 with mutated mRNA was recently suggested by molecular dynamics (MD) studies highlighting the importance of H-bonding and stacking π-π interactions. To improve the readthrough activity we changed the fluorine number and position in the PTC124 fluoroaryl moiety. The readthrough ability of these PTC124 derivatives was tested in human cells harboring reporter plasmids with premature stop codons in H2BGFP and FLuc genes as well as in cystic fibrosis (CF) IB3.1 cells with a nonsense mutation. Maintaining low toxicity, three of these molecules showed higher efficacy than PTC124 in the readthrough of the UGA premature stop codon and in recovering the expression of the CFTR protein in IB3.1 cells from cystic fibrosis patient. Molecular dynamics simulations performed with mutated CFTR mRNA fragments and active or inactive derivatives are in agreement with the suggested interaction of PTC124 with mRNA. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

  15. Essential PTC Mathcad Prime 3.0 a guide for new and current users

    CERN Document Server

    Maxfield, Brent

    2013-01-01

    Learn how to use PTC Mathcad Prime 3.0, one of the world's leading tools for technical computing, in the context of engineering, science, and math applications. Quickly harness the power of Mathcad to solve simple and complex problems. Essential PTC Mathcad is perfect for college students and first-time users as well as for experienced Mathcad users who are moving to Prime 3.0. The book introduces the most powerful functions and features of the new Prime 3.0 software and teaches how to apply them to create comprehensive calculations for any quantitative subject. Examples from several fields

  16. Steady-state solution of the PTC thermistor problem using a quadratic spline finite element method

    Directory of Open Access Journals (Sweden)

    Bahadir A. R.

    2002-01-01

    Full Text Available The problem of heat transfer in a Positive Temperature Coefficient (PTC thermistor, which may form one element of an electric circuit, is solved numerically by a finite element method. The approach used is based on Galerkin finite element using quadratic splines as shape functions. The resulting system of ordinary differential equations is solved by the finite difference method. Comparison is made with numerical and analytical solutions and the accuracy of the computed solutions indicates that the method is well suited for the solution of the PTC thermistor problem.

  17. Crypto heater:a design fiction

    OpenAIRE

    Lindley, Joseph

    2015-01-01

    This proposal is to exhibit the work named Crypto Heater which is part of a design fiction [c.f 1,5,8:30] series intended to explore a near future world in which cryptographic currencies such as Bitcoin [6] have become commonplace. This work opens up space for discussion about the activities of the distributed peer-to-peer network of so-called "miners" that ensure the security of the Bitcoin network and regulate the supply of new currency in the Bitcoin economy. The physical part of the work ...

  18. The Industrial Design of Water Heater

    Institute of Scientific and Technical Information of China (English)

    张萌萌

    2014-01-01

    The design was inspired by the understanding to the fine life understanding of life, relaxed requirement and under-standing of fashion. Each link of easy life present in the water heater design. The principle of"artappliances, life"brand phi-losophy, refined and understated elegance is the core essence, is also the brand logo. In the"draw the fine life inspiration, the core brand design language create eternal artistic quality", every product tothe interpretation of home life art trend, to embody the elegant life style annotation and experience, committed to the urban elites to create exquisitelife style.

  19. Status of Hollow Cathode Heater Development for the Space Station Plasma Contactor

    Science.gov (United States)

    Soulas, George C.

    1994-01-01

    A hollow cathode-based plasma contactor has been selected for use on the Space Station. During the operation of the plasma contactor, the hollow cathode heater will endure approximately 12000 thermal cycles. Since a hollow cathode heater failure would result in a plasma contactor failure, a hollow cathode heater development program was established to produce a reliable heater. The development program includes the heater design, process documents for both heater fabrication and assembly, and heater testing. The heater design was a modification of a sheathed ion thruster cathode heater. Heater tests included testing of the heater unit alone and plasma contactor and ion thruster testing. To date, eight heaters have been or are being processed through heater unit testing, two through plasma contactor testing and three through ion thruster testing, all using direct current power supplies. Comparisons of data from heater unit performance tests before cyclic testing, plasma contactor tests, and ion thruster tests at the ignition input current level show the average deviation of input power and tube temperature near the cathode tip to be +/-0.9 W and +/- 21 C, respectively. Heater unit testing included cyclic testing to evaluate reliability under thermal cycling. The first heater, although damaged during assembly, completed 5985 ignition cycles before failing. Four additional heaters successfully completed 6300, 6300, 700, and 700 cycles. Heater unit testing is currently ongoing for three heaters which have to date accumulated greater than 7250, greater than 5500, and greater than 5500 cycles, respectively.

  20. RET/PTC Rearrangements Are Associated with Elevated Postoperative TSH Levels and Multifocal Lesions in Papillary Thyroid Cancer without Concomitant Thyroid Benign Disease.

    Science.gov (United States)

    Su, Xuan; He, Caiyun; Ma, Jiangjun; Tang, Tao; Zhang, Xiao; Ye, Zulu; Long, Yakang; Shao, Qiong; Shao, Jianyong; Yang, Ankui

    2016-01-01

    RET/PTC rearrangements, resulting in aberrant activity of the RET protein tyrosine kinase receptor, occur exclusively in papillary thyroid cancer (PTC). In this study, we examined the association between RET/PTC rearrangements and thyroid hormone homeostasis, and explored whether concomitant diseases such as nodular goiter and Hashimoto's thyroiditis influenced this association. A total of 114 patients diagnosed with PTC were enrolled in this study. Thyroid hormone levels, clinicopathological parameters and lifestyle were obtained through medical records and surgical pathology reports. RET/PTC rearrangements were detected using TaqMan RT-PCR and validated by direct sequencing. No RET/PTC rearrangements were detected in benign thyroid tissues. RET/PTC rearrangements were detected in 23.68% (27/114) of PTC tissues. No association between thyroid function, clinicopathological parameters and lifestyle was observed either in total thyroid cancer patients or the subgroup of patients with concomitant disease. In the subgroup of PTC patients without concomitant disease, RET/PTC rearrangement was associated with multifocal cancer (P = 0.018). RET/PTC rearrangement was also correlated with higher TSH levels at one month post-surgery (P = 0.037). Based on likelihood-ratio regression analysis, the RET/PTC-positive PTC cases showed an increased risk of multifocal cancers in the thyroid gland (OR = 5.57, 95% CI, 1.39-22.33). Our findings suggest that concomitant diseases such as nodular goiter and Hashimoto's thyroiditis in PTC may be a confounding factor when examining the effects of RET/PTC rearrangements. Excluding the potential effect of this confounding factor showed that RET/PTC may confer an increased risk for the development of multifocal cancers in the thyroid gland. Aberrantly increased post-operative levels of TSH were also associated with RET/PTC rearrangement. Together, our data provides useful information for the treatment of papillary thyroid cancer.

  1. Biogas Digester with Simple Solar Heater

    Directory of Open Access Journals (Sweden)

    Kh S Karimov

    2012-10-01

    Full Text Available ABSTRACT: In this research work, the design, fabrication and investigation of a biogas digester with simple solar heater are presented. For the solar heater, a built-in reverse absorber type heater was used. The maximum temperature (50°C inside the methane tank was taken as a main parameter for the design of the digester. Then, the energy balance equation for the case of a static mass of fluid being heated was used to model the process. The parameters of thermal insulation of the methane tank were also included in the calculations. The biogas digester consisted of a methane tank with built-in solar reverse absorber heater to harness the radiant solar energy for heating the slurry comprising of different organic wastes (dung, sewage, food wastes etc.. The methane tank was initially filled to 70% of its volume with organic wastes from the GIK institute’s sewage. The remaining volume was filled with sewage and cow dung from other sources. During a three month period (October-December, 2009 and another two month period (February-March, 2010, the digester was investigated. The effects of solar radiation on the absorber, the slurry’s temperature, and the ambient temperature were all measured during these investigations. It was found that using sewage only and sewage with cow dung in the slurry resulted in retention times of four and two weeks, respectively. The corresponding biogas produced was 0.4 m3 and 8.0 m3, respectively. Finally, this paper also elaborates on the upgradation of biogas through the removal of carbon dioxide, hydrogen sulphide and water vapour, and also the process of conversion of biogas energy into electric powerABSTRAK: Kajian ini membentangkan rekabentuk, fabrikasi dan penyelidikan tentang pencerna biogas dengan pemanas solar ringkas. Sebagai pemanas solar, ia dilengkapkan dengan penyerap pemanas beralik. Suhu maksimum(50oC di dalam tangki metana telah diambil sebagai parameter utama rekabentuk pencerna. Dengan menggunakan

  2. Parametric excitation of whistler waves by HF heater

    Science.gov (United States)

    Kuo, S. P.; Lee, M. C.

    1989-01-01

    Possible generation of whistler waves by Tromso HF heater is investigated. It is shown that the HF heater wave can parametrically decay into a whistler wave and a Langmuir wave. Since whistler waves may have a broad range of frequency, the simultaneously excited Langmuir waves can have a much broader frequency bandwidth than those excited by the parametric decay instability.

  3. 46 CFR 111.85-1 - Electric oil immersion heaters.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Electric oil immersion heaters. 111.85-1 Section 111.85-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) ELECTRICAL ENGINEERING ELECTRIC SYSTEMS-GENERAL REQUIREMENTS Electric Oil Immersion Heaters § 111.85-1 Electric oil immersion...

  4. Hydrogenation of fructose to 2,5-dimethyltetrahydrofuran using a sulfur poisoned Pt/C catalyst

    Science.gov (United States)

    In order to expand the number of biobased chemicals available, fructose has been hydrogenated to 2,5-dimethyltetrahydrofuran using a sulfided Pt/C catalyst. The reaction was carried out in a stirred reactor at 10.3 MPa H2 and 175°C which allowed a 10% fructose solution to be converted in about 2 h. ...

  5. Implications of a PTC Extension on U.S. Wind Deployment

    Energy Technology Data Exchange (ETDEWEB)

    Lantz, E.; Steinberg, D.; Mendelsohn, M.; Zinaman, O.; James, T.; Porro, G.; Hand, M.; Mai, T.; Logan, J.; Heeter, J.; Bird, L.

    2014-04-01

    This analysis explores the potential effects of wind production tax credit expiration and various extension scenarios on future wind deployment with the Regional Energy Deployment System (ReEDS), a model of the U.S. electricity sector. The analysis does not estimate the potential implications on government tax revenue associated with the PTC. Key findings include: Under a scenario in which the PTC is not extended and all other policies remain unchanged, wind capacity additions are expected to be between 3 and 5 GW per year from 2013-2020; PTC extension options that ramp-down from the current level to zero-credit by year-end 2022 appear to be insufficient to support deployment at the recent historical average; Extending the PTC at its historical level may provide the best opportunity to support deployment consistent with recent levels across a range of potential market conditions; it therefore may also provide the best opportunity to sustain wind power installation and manufacturing sector at current levels.

  6. Activated RET/PTC oncogene elicits immediate early and delayed response genes in PC12 cells.

    Science.gov (United States)

    Califano, D; Monaco, C; de Vita, G; D'Alessio, A; Dathan, N A; Possenti, R; Vecchio, G; Fusco, A; Santoro, M; de Franciscis, V

    1995-07-06

    The expression of the receptor-like tyrosine kinase RET is associated with tumors, tissues or cell lines of neural crest origin. In addition RET products (Ret) are involved in determining cell fate during the differentiation of the enteric nervous system and during renal organogenesis. However, as yet, no direct evidence exists to indicate that the Ret kinase activity might interfere in a specific way with cellular differentiation, or proliferation, of a neural crest derived cell line. By using two constitutively activated forms of RET (RET/PTC1 and RET/PTC3) in transient transfection experiments, we have obtained evidence that active RET could reprogramme the gene expression pattern in the rat pheochromocytoma PC12 cell line. Transcription driven by gene promoters, such as NGFI-A and vgf, which belong, respectively, to primary and delayed response genes to nerve growth factor (NGF), and by the neuron-specific enolase (NSE) promoter, is rapidly induced by the expression of activated RET oncogenes. This induction is not elicited in other non neural derived cell types tested. We also demonstrate that endogenous ras activity is required for RET induction of these neural markers. Finally, in the RET/PTC transfected PC12 cells, NGF is unable to induce further their transcription. This suggests that RET/PTC could share an intracellular signalling pathway with the NGF-receptor.

  7. High osmolarity glycerol response PtcB phosphatase is important for Aspergillus fumigatus virulence.

    Science.gov (United States)

    Winkelströter, Lizziane K; Bom, Vinícius Leite Pedro; de Castro, Patrícia Alves; Ramalho, Leandra Naira Zambelli; Goldman, Maria Helena S; Brown, Neil Andrew; Rajendran, Ranjith; Ramage, Gordon; Bovier, Elodie; Dos Reis, Thaila Fernanda; Savoldi, Marcela; Hagiwara, Daisuke; Goldman, Gustavo H

    2015-04-01

    Aspergillus fumigatus is a fungal pathogen that is capable of adapting to different host niches and to avoid host defenses. An enhanced understanding of how, and which, A. fumigatus signal transduction pathways are engaged in the regulation of these processes is essential for the development of improved disease control strategies. Protein phosphatases are central to numerous signal transduction pathways. To comprehend the functions of protein phosphatases in A. fumigatus, 32 phosphatase catalytic subunit encoding genes were identified. We have recognized PtcB as one of the phosphatases involved in the high osmolarity glycerol response (HOG) pathway. The ΔptcB mutant has both increased phosphorylation of the p38 MAPK (SakA) and expression of osmo-dependent genes. The ΔptcB strain was more sensitive to cell wall damaging agents, had increased chitin and β-1,3-glucan, and impaired biofilm formation. The ΔptcB strain was avirulent in a murine model of invasive pulmonary aspergillosis. These results stress the importance of the HOG pathway in the regulation of pathogenicity determinants and virulence in A. fumigatus.

  8. 49 CFR 236.1006 - Equipping locomotives operating in PTC territory.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Equipping locomotives operating in PTC territory. 236.1006 Section 236.1006 Transportation Other Regulations Relating to Transportation (Continued... territory. (a) Except as provided in paragraph (b) of this section, each train operating on any...

  9. Catalytic Liquefaction of Humin Substances from Sugar Biorefineries with Pt/C in 2-Propanol

    NARCIS (Netherlands)

    Wang, Y.; Agarwal, S.; Heeres, H. J.

    The catalytic liquefaction of humins, the solid byproduct from the conversion of C6 sugars (glucose, fructose) to S-hydroxymethylfurfural (HMF) and levulinic acid (LA), using a supported Pt/C catalyst in isopropanol (IPA) as the solvent was investigated. At bench mark conditions (400 degrees C, 7 h,

  10. When Proteins Start to Make Sense: Fine-tuning Aminoglycosides for PTC Suppression Therapy.

    Science.gov (United States)

    Shalev, Moran; Baasov, Timor

    2014-08-01

    Aminoglycosides (AGs) are highly potent antibacterial agents, which are known to exert their deleterious effects on bacterial cells by interfering with the translation process, leading to aberrant protein synthesis that usually results in cell death. Nearly 45 years ago, AGs were shown to induce read-through activity in prokaryotic systems by selectively encoding tRNA molecules at premature termination codon (PTC) positions; resulting in the generation of full length functional proteins. However, only in the last 20 years this ability has been demonstrated in eukaryotic systems, highlighting their potential as therapeutic agents to treat PTC induced genetic disorders. Despite the great potential, AGs use in these manners is quite restricted due to relatively high toxicity values observed upon their administration. Over the last few years several synthetic derivatives were developed to overcome some of the enhanced toxicity issues, while in parallel showed significantly improved PTC suppression activity in various in-vitro, ex-vivo and in-vivo models of a variety of different diseases models underling by PTC mutations. Although these derivatives hold great promise to serve as therapeutic candidates they also demonstrate the necessity to further understand the molecular mechanisms of which AGs confer their biological activity in eukaryotic cells for further rational drug design. Recent achievements in structural research shed light on AGs mechanism of action and opened a new avenue in the development of new and improved therapeutic derivatives. The following manuscript highlights these accomplishments and summarizes their contributions to the state of art rational drug design.

  11. RET/PTC rearrangement is prevalent in follicular Hurthle cell carcinomas

    NARCIS (Netherlands)

    de Vries, Margriet M.; Celestino, Ricardo; Castro, Patricia; Eloy, Catarina; Maximo, Valdemar; van der Wal, Jacqueline E.; Plukker, John T. M.; Links, Thera P.; Hofstra, Robert M. W.; Sobrinho-Simoes, Manuel; Soares, Paula

    2012-01-01

    Aims: The molecular alterations underlying follicular Hurthle cell carcinomas (FHCCs) are largely unknown. In an attempt to clarify this issue, we analysed a series of Hurthle cell tumours for the presence of RET/PTC and PAX8/PPARG rearrangements and BRAF, HRAS and NRAS mutations. Methods and result

  12. PTC 2005: Pulaski Technical College's Strategic Plan for Serving Central Arkansas.

    Science.gov (United States)

    Johnson, Mark

    Intended as a long-range agenda for Arkansas' Pulaski Technical College (PTC), this plan describes the planning process used at the college, sets forth college goals through the year 2005, and reviews strategies to help the college achieve its goals. Following introductory sections, the educational and training needs of Central Arkansas are…

  13. Association of ATM Gene Polymorphism with PTC Metastasis in Female Patients.

    Science.gov (United States)

    Gu, Yulu; Liu, Xiaoli; Yu, Yaqin; Shi, Jieping; Ai, Lizhe; Sun, Hui; Kanu, Joseph Sam; Wang, Chong; Liu, Yawen

    2014-01-01

    Ataxia telangiectasia mutated (ATM) gene is critical in the process of recognizing and repairing DNA lesions and is related to invasion and metastasis of malignancy. The incidence rate of papillary thyroid cancer (PTC) has increased for several decades and is higher in females than males. In this study, we want to investigate whether ATM polymorphisms are associated with gender-specific metastasis of PTC. 358 PTC patients in Northern China, including 109 males and 249 females, were included in our study. Four ATM single nucleotide polymorphisms (SNPs) were genotyped using Matrix-Assisted Laser Desorption/Ionization Time of Flight Mass Spectrometry (MALDI-TOF-MS). Association between genotypes and the gender-specific risk of metastasis was assessed by odds ratios (OR) and 95% confidence intervals (CI) under the unconditional logistic regression analysis. Significant associations were observed between rs189037 and metastasis of PTC in females under different models of inheritance (codominant model: OR = 0.15, 95% CI 0.04-0.56, P = 0.01 for GA versus GG and OR = 0.08, 95% CI 0.01-0.74, P = 0.03 for AA versus GG, resp.; dominant model: OR = 0.49, 95% CI 0.25-0.98, P = 0.04; overdominant model: OR = 0.47, 95% CI 0.25-0.89, P = 0.02). However, no association remained significant after Bonferroni correction. Our findings suggest a possible association between ATM rs189037 polymorphisms and metastasis in female PTCs.

  14. Infrared transparent graphene heater for silicon photonic integrated circuits.

    Science.gov (United States)

    Schall, Daniel; Mohsin, Muhammad; Sagade, Abhay A; Otto, Martin; Chmielak, Bartos; Suckow, Stephan; Giesecke, Anna Lena; Neumaier, Daniel; Kurz, Heinrich

    2016-04-18

    Thermo-optical tuning of the refractive index is one of the pivotal operations performed in integrated silicon photonic circuits for thermal stabilization, compensation of fabrication tolerances, and implementation of photonic operations. Currently, heaters based on metal wires provide the temperature control in the silicon waveguide. The strong interaction of metal and light, however, necessitates a certain gap between the heater and the photonic structure to avoid significant transmission loss. Here we present a graphene heater that overcomes this constraint and enables an energy efficient tuning of the refractive index. We achieve a tuning power as low as 22 mW per free spectral range and fast response time of 3 µs, outperforming metal based waveguide heaters. Simulations support the experimental results and suggest that for graphene heaters the spacing to the silicon can be further reduced yielding the best possible energy efficiency and operation speed.

  15. Toxic organic pollutants from kerosene space heaters in Iran.

    Science.gov (United States)

    Keyanpour-Rad, Mansoor

    2004-03-01

    The aim of this study was to investigate qualitatively the emission of toxic organic pollutants from an unventilated conventional kerosene space heater commonly used in Iran. A brand new common convective kerosene space heater, the "Aladdin," was used for this study. The well-tuned convective heater was operated in a 2.6-m(3) test chamber and then the emission was tested for organic pollutants. The emission was collected on Teflon-impregnated glass-fiber filters and XAD-2 resin and then analyzed by gas chromatography-mass spectroscopy. It was found that in addition to the ordinary pollutant gases, the heater emits aliphatic hydrocarbons, alcohols, polyaromatic hydrocarbons and the related nitrated compounds, phthalates, naphthalenes, and some other toxic organic compounds. However, it was found that the heater did not emit fluoranthene, cyclohexane, benzoic acid, and higher-molecular-weight alkylbenzenes, which could have resulted from the combustion of some other types of kerosene.

  16. Note: Improved heater design for high-temperature hollow cathodes

    Science.gov (United States)

    McDonald, M. S.; Gallimore, A. D.; Goebel, D. M.

    2017-02-01

    We present an improved heater design for thermionic cathodes using a rhenium filament encased in a boron nitride ceramic sleeve. This heater is relatively simple to fabricate, yet has been successfully used to reliably and repeatably light a lanthanum hexaboride (LaB6) hollow cathode based on a previously published design without noticeable filament degradation over hundreds of hours of operation. The high decomposition temperature of boron nitride (2800 C for inert environments) and melting point for rhenium (3180 C) make this heater especially attractive for use with LaB6, which may require operating temperatures upwards of 1700 C. While boron nitride decomposes in air above 1000 C, the heater was used only at vacuum with an inert gas discharge, and no degradation was observed. Limitations of current state of the art cathode heaters are also discussed and compared with the rhenium-boron nitride combination.

  17. MIR141 expression differentiates Hashimoto Thyroiditis from PTC and benign thyrocytes in Irish archival thyroid tissues

    Directory of Open Access Journals (Sweden)

    Emma R Dorris

    2012-09-01

    Full Text Available MicroRNAs (miRNAs are small non-coding RNAs approximately 22 nucleotides in length that function as regulators of gene expression. Dysregulation of miRNAs has been associated with initiation and progression of oncogenesis in humans. Our group has previously described a unique miRNA expression signature, including the MIR200 family member MIR141, which can differentiate papillary thyroid cancer (PTC cell lines from a control thyroid cell line. An investigation into the expression of MIR141 in a series of archival thyroid malignancies (n=140; classic PTC, follicular variant PTC, follicular thyroid carcinoma (FTC, Hashimoto thyroiditis (HT, or control thyrocytes was performed. Each cohort had a minimum of 20 validated samples surgically excised within the period 1980 - 2009. A subset of the HT and cPTC cohorts (n=3 were also analysed for expression of TGFβR1, a key member of the TGFβ pathway and known target of MIR141. Laser capture microdissection was used to specifically dissect target cells from formalin-fixed paraffin-embedded archival tissue. Thyrocyte- and lymphocyte-specific markers (TSHR and LSP1 respectively confirmed the integrity of cell populations in the HT cohort. RNA was extracted and quantitative RT-PCR was performed using comparative CT (ΔΔCT analysis. Statistically significant (p<0.05 differential expression profiles of MIR141 were found between tissue types. HT samples displayed significant downregulation of MIR141 compared to both classic PTC and control thyrocytes. Furthermore, TGFβR1 expression was detected in cPTC samples but not in HT thyrocytes. It is postulated that the down-regulation of this miRNA is due, at least in part, to its involvement in regulating the TGFβ pathway. This pathway is exquisitely involved in T-cell autoimmunity and has previously been linked with HT. In conclusion, HT epithelium can be distinguished from cPTC epithelium and control epithelium based on the relative expression of MIR141.

  18. Upregulation of Shh and Ptc1 in hyperoxia‑induced acute lung injury in neonatal rats.

    Science.gov (United States)

    Dang, Hongxing; Wang, Shaohua; Yang, Lin; Fang, Fang; Xu, Feng

    2012-08-01

    The aim of the present study was to observe the expression of sonic hedgehog (Shh) and Ptc signaling molecules in the lungs of newborn rats exposed to prolonged hyperoxia, and to explore the role of the SHH signaling pathway in hyperoxia‑induced lung injury. Newborn Sprague-Dawley rat pups were placed in chambers containing room air or oxygen above 95% for 14 days following birth. The rats were sacrificed after 3, 7 or 14 days and their lungs were removed. Sections were fixed and subjected to hematoxylin and eosin (H&E) staining. Shh and Ptc1 were quantitated by immunohistochemistry. The total RNA and protein were also extracted from lung tissue; real-time PCR (RT-PCR) and western blot analysis were utilized to assess the mRNA and protein expression of Shh and Ptc1. H&E staining demonstrated significant histomorphological changes in the hyperoxia‑exposed lungs at 3, 7 and 14 days of age. The results of the immunohistochemistry, RT-PCR and western blot analysis demonstrated that the expression of Shh was significantly higher in the hyperoxia-exposed lungs at 3, 7 and 14 days, while Ptc1 was significantly elevated at 7 and 14 days. Exposure of the neonatal rat lung to prolonged hyperoxia resulted in acute lung injury and histomorphological changes. Shh and Ptc1 were upregulated in a time-dependent manner in the course of hyperoxia-induced lung injury. The SHH signal pathway may be involved in the pathogenesis of hyperoxia-induced lung injury. This is the first evidence that in vivo hyperoxia induces activation of the SHH signal transduction pathway in newborn lung.

  19. Use of a combined SpO₂/PtcCO₂ sensor in the delivery room.

    Science.gov (United States)

    Rubortone, Serena Antonia; De Carolis, Maria Pia; Lacerenza, Serafina; Bersani, Iliana; Occhipinti, Federica; Romagnoli, Costantino

    2012-01-01

    Arterial oxygen saturation (SaO(2)) and partial arterial pressure of carbon dioxide (PaCO(2)) are important respiratory parameters in critically ill neonates. A sensor combining a pulse oximeter with the Stow-Severinghaus electrode, required for the measurement of peripheral oxygen saturation (SpO(2)) and transcutaneous partial pressure of carbon dioxide (PtcCO(2)), respectively, has been recently used in neonatal clinical practice (TOSCA(500Ò)Radiometer). We evaluated TOSCA usability and reliability in the delivery room (DR), throughout three different periods, on term, late-preterm, and preterm neonates. During the first period (period A), 30 healthy term neonates were simultaneously monitored with both TOSCA and a MASIMO pulse oximeter. During the second period (period B), 10 healthy late-preterm neonates were monitored with both TOSCA and a transcutaneous device measuring PtcCO(2) (TINA(Ò) TCM3, Radiometer). During the third period (period C), 15 preterm neonates were monitored with TOSCA and MASIMO after birth, during stabilization, and during transport to the neonatal intensive care unit (NICU). Blood gas analyses were performed to compare transcutaneous and blood gas values. TOSCA resulted easily and safely usable in the DR, allowing reliable noninvasive SaO(2) estimation. Since PtcCO(2) measurements with TOSCA required at least 10 min to be stable and reliable, this parameter was not useful during the early resuscitation immediately after birth. Moreover, PtcCO(2) levels were less precise if compared to the conventional transcutaneous monitoring. However, PtcCO(2) measurement by TOSCA was useful as trend-monitoring after stabilization and during transport to NICU.

  20. Mechanism of PTC124 activity in cell-based luciferase assays of nonsense codon suppression

    Science.gov (United States)

    Auld, Douglas S.; Thorne, Natasha; Maguire, William F.; Inglese, James

    2009-01-01

    High-throughput screening (HTS) assays used in drug discovery frequently use reporter enzymes such as firefly luciferase (FLuc) as indicators of target activity. An important caveat to consider, however, is that compounds can directly affect the reporter, leading to nonspecific but highly reproducible assay signal modulation. In rare cases, this activity appears counterintuitive; for example, some FLuc inhibitors, acting through posttranslational Fluc reporter stabilization, appear to activate gene expression. Previous efforts to characterize molecules that influence luciferase activity identified a subset of 3,5-diaryl-oxadiazole-containing compounds as FLuc inhibitors. Here, we evaluate a number of compounds with this structural motif for activity against FLuc. One such compound is PTC124 {3-[5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl]benzoic acid}, a molecule originally identified in a cell-based FLuc assay as having nonsense codon suppression activity [Welch EM, et al., Nature (2007) 447:87–91]. We find that the potency of FLuc inhibition for the tested compounds strictly correlates with their activity in a FLuc reporter cell-based nonsense codon assay, with PTC124 emerging as the most potent FLuc inhibitor (IC50 = 7 ± 1 nM). However, these compounds, including PTC124, fail to show nonsense codon suppression activity when Renilla reniformis luciferase (RLuc) is used as a reporter and are inactive against the RLuc enzyme. This suggests that the initial discovery of PTC124 may have been biased by its direct effect on the FLuc reporter, implicating firefly luciferase as a molecular target of PTC124. Our results demonstrate the value of understanding potential interactions between reporter enzymes and chemical compounds and emphasize the importance of implementing the appropriate control assays before interpreting HTS results. PMID:19208811

  1. Integrity Assessment of GOH Heater Tube

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Bong Sang; Hong, J. H.; Oh, Y. J.; Yoon, J. H.; Oh, J. M. [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

    1997-08-01

    An assessment of structural integrity of ASTM A312-TP347 GOH heater tube was performed. The surface notches which had been produced during tube manufacturing process were analyzed microscopically. Chemical analysis, hardness tests, tensile tests, and J-Integral fracture resistance tests were carried out to compare the mechanical properties with those of the material specification and also with the other material of the same type. The test results showed the mechanical properties of the GOH tube material are within the specification range. An elastic-plastic fracture mechanics analysis based on the DPFAD method reveals the tube an appropriate safety margin for the normal operation. 13 refs., 5 tabs., 24 figs. (author)

  2. Ptc6 is required for proper rapamycin-induced down-regulation of the genes coding for ribosomal and rRNA processing proteins in S. cerevisiae.

    Directory of Open Access Journals (Sweden)

    Asier González

    Full Text Available Ptc6 is one of the seven components (Ptc1-Ptc7 of the protein phosphatase 2C family in the yeast Saccharomyces cerevisiae. In contrast to other type 2C phosphatases, the cellular role of this isoform is poorly understood. We present here a comprehensive characterization of this gene product. Cells lacking Ptc6 are sensitive to zinc ions, and somewhat tolerant to cell-wall damaging agents and to Li(+. Ptc6 mutants are sensitive to rapamycin, albeit to lesser extent than ptc1 cells. This phenotype is not rescued by overexpression of PTC1 and mutation of ptc6 does not reproduce the characteristic genetic interactions of the ptc1 mutation with components of the TOR pathway, thus suggesting different cellular roles for both isoforms. We show here that the rapamycin-sensitive phenotype of ptc6 cells is unrelated to the reported role of Pt6 in controlling pyruvate dehydrogenase activity. Lack of Ptc6 results in substantial attenuation of the transcriptional response to rapamycin, particularly in the subset of repressed genes encoding ribosomal proteins or involved in rRNA processing. In contrast, repressed genes involved in translation are Ptc6-independent. These effects cannot be attributed to the regulation of the Sch9 kinase, but they could involve modulation of the binding of the Ifh1 co-activator to specific gene promoters.

  3. 49 CFR Appendix F to Part 236 - Minimum Requirements of FRA Directed Independent Third-Party Assessment of PTC System Safety...

    Science.gov (United States)

    2010-10-01

    ... Third-Party Assessment of PTC System Safety Verification and Validation F Appendix F to Part 236... F to Part 236—Minimum Requirements of FRA Directed Independent Third-Party Assessment of PTC System... independent third-party assessment of PTC system safety verification and validation pursuant to subpart H or I...

  4. Fluid bed solids heater. Final technical report

    Energy Technology Data Exchange (ETDEWEB)

    Preuit, L. C.

    1980-01-01

    A solids heater which operates at up to 2000 F was designed, fabricated, installed and operated through checkout at the Morgantown Energy Technology Center at Morgantown, West Virginia. The system, designated the 2000 F Fluid Bed Solids Heater (FBSH) uses a fluidized bed to heat limestone to 600 F and aluminium oxide or silicon carbide to 2000 F and discharges heated solids upon demand. The FBSH with added valve handling and pressurization equipment is known as the Valve Hot Solids Test Unit and is intended for use by the US Department of Energy for testing of valves for severe service applications in coal conversion and utilization processes. The FBSH as designed and supplied by Combustion Power Company includes process equipment, controls, the enclosing building and other associated equipment. In the 600 F range of operation it can circulate limestone through two valve test trains simultaneously on a continuous basis. Only one valve test train is used for 2000 F solids and operation in that range is also continuous. Limestone, crushed to minus 5/16 size, is heated, discharged, and recycled at a maximum average rate of 250 lb/min while aluminum oxide or silicon carbide, No. 8 grit, is circulated at rates up to 167 lb/min. The FBSH control system is designed for automatic operation, and capability is included for external computerized data acquisition and/or supervisory control. An operating and maintenance manual and as-built drawings have been submitted. This report describes the FBSH equipment, its design basis, and its operation. It has been prepared and submitted in fulfillment of Contract Number DIAC05-77ET10499.

  5. Analysis of Leak and Plugging Condition for Feedwater Heaters

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Hansul; Kang, Yeon Kwan; Heo, Gyunyoung [Kyung Hee University, Yongin (Korea, Republic of); Song, Seok Yoon; Oh, Seung Hwan [Korea Hydro and Nuclear Power, Daejeon (Korea, Republic of)

    2015-10-15

    Tube damage in feedwater heater occurs from damaged pressure boundary, inflow of foreign substances, erosion and corrosion. Once a heat tube is damaged, the water jet from the damaged spot is spread out to surrounding tubes. Since a feedwater heater is operated under 2-phase flow condition and has physically complicated structure, it cannot be approached on shell side. Therefore, test and inspection to check tube degradation is relatively difficult. Even though tube leak does not affect surrounding tubes, it obviously affects efficiency of turbine cycle and reduces economic feasibility in the long run. For this reason, systematic management is required on thermal performance for feedwater heaters. In this paper, PEPSE (Performance Evaluation of Power System Efficiency), one of the generic-purpose power plant simulation program, was used to construct a heat balance model for turbine cycle. The model was used to analyze the effect of change in key variables related to thermal performance of feedwater heater on turbine cycle, thereby preparing a thermal performance management strategy for feedwater heaters. Study was conducted on 6 units that represent each reactor type among domestic nuclear power plants (NPPs) in operation, but this paper described the results of high pressure feedwater heaters in a Korean standard NPP, which shows high possibility of tube damage due to large shell-tube pressure difference. In this paper, the heat balance models for turbine cycle were constructed as a part of effort to develop the thermal performance management system for feedwater heaters in NPPs.

  6. Thermal emission of neutron stars with internal heaters

    CERN Document Server

    Kaminker, A D; Potekhin, A Y; Yakovlev, D G

    2014-01-01

    Using 1D and 2D cooling codes we study thermal emission from neutron stars with steady state internal heaters of various intensities and geometries (blobs or spherical layers) located at different depths in the crust. The generated heat tends to propagate radially, from the heater down to the stellar core and up to the surface; it is also emitted by neutrinos. In local regions near the heater the results are well described with the 1D code. The heater's region projects onto the stellar surface forming a hot spot. There are two heat propagation regimes. In the first, conduction outflow regime (realized at heat rates $H_0 \\lesssim 10^{20}$ erg cm$^{-3}$ s$^{-1}$ or temperatures $T_\\mathrm{h} \\lesssim 10^9$ K in the heater) the thermal surface emission of the star depends on the heater's power and neutrino emission in the stellar core. In the second, neutrino outflow regime ($H_0 \\gtrsim 10^{20}$ erg cm$^{-3}$ s$^{-1}$ or $T_\\mathrm{h} \\gtrsim 10^9$ K) the surface thermal emission becomes independent of heater's...

  7. The use of PTC and RFA as treatment alternatives with low procedural morbidity in non-small cell lung cancer.

    Science.gov (United States)

    Choe, Yeong Hun; Kim, So Ri; Lee, Kyung Sun; Lee, Ka Young; Park, Seoung Ju; Jin, Gong Yong; Lee, Yong Chul

    2009-07-01

    Minimally invasive percutaneous ablative therapies for treating lung cancers are currently being studied as treatment alternatives. This present study investigated the efficacies of percutaneous thoracic cryotherapy (PTC) and radiofrequency ablation (RFA) on clinical courses of pulmonary malignant tumours, especially in the setting of non-surgical candidates. Sixty-five patients with lung malignancy underwent sixty-seven sessions of RFA and nine sessions of PTC. We evaluated the results of RFA and PTC including efficacies, local progression rate, survival rate, and complications. Twenty-nine patients (43.3%) treated with RFA and six patients (66.7%) with PTC attained complete ablation. In small-sized lung mass (3 cm), complete ablation rate of RFA and PTC was increased to 76.2% and 85.7%, respectively. Additionally, we have found that the complete ablation group had significantly higher survival duration and progression free survival duration compared with the partial ablation group. Moreover, the complication profile was acceptable and the pain associated with the procedures disappeared within 1 day; 42 patients (62.7%) after RFA and all patients after PTC. This study provides evidence for the use of PTC and RFA as treatment alternatives with low procedural morbidity in the management of inoperable pulmonary malignant tumours, although the current study is limited by the small sample size and the short follow-up period.

  8. The BMI1 inhibitor PTC-209 is a potential compound to halt cellular growth in biliary tract cancer cells.

    Science.gov (United States)

    Mayr, Christian; Wagner, Andrej; Loeffelberger, Magdalena; Bruckner, Daniela; Jakab, Martin; Berr, Frieder; Di Fazio, Pietro; Ocker, Matthias; Neureiter, Daniel; Pichler, Martin; Kiesslich, Tobias

    2016-01-05

    BMI1 is a core component of the polycomb repressive complex 1 (PRC1) and is up-regulated in biliary tract cancer (BTC), contributing to aggressive clinical features. In this study we investigated the cytotoxic effects of PTC-209, a recently developed inhibitor of BMI1, in BTC cells. PTC-209 reduced overall viability in BTC cell lines in a dose-dependent fashion (0.04 - 20 µM). Treatment with PTC-209 led to slightly enhanced caspase activity and stop of cell proliferation. Cell cycle analysis revealed that PTC-209 caused cell cycle arrest at the G1/S checkpoint. A comprehensive investigation of expression changes of cell cycle-related genes showed that PTC-209 caused significant down-regulation of cell cycle-promoting genes as well as of genes that contribute to DNA synthesis initiation and DNA repair, respectively. This was accompanied by significantly elevated mRNA levels of cell cycle inhibitors. In addition, PTC-209 reduced sphere formation and, in a cell line-dependent manner, aldehyde dehydrogease-1 positive cells. We conclude that PTC-209 might be a promising drug for future in vitro and in vivo studies in BTC.

  9. ret/PTC-1 expression alters the immunoprofile of thyroid follicular cells

    Directory of Open Access Journals (Sweden)

    Aherne Sinead

    2008-05-01

    Full Text Available Abstract Background Hashimoto Thyroiditis (H.T. is a destructive autoimmune thyroid condition whose precise molecular pathogenesis remains unclear. ret/PTC-1 is a chimeric transcript which has been described in autoimmune thyroid disease (AITD and thyroid neoplasia. The purpose of this study was to observe the immunogenic effect exposure to H.T. and control lymphocyte supernatant would have on normal (Nthy-ori and ret/PTC-1 (TPC-1 expressing thyroid cell line models. Results A 2 × 2 matrix comprising Nthy-ori and TPC-1 cell lines and H.T. and control lymphocyte supernatant was designed and utilised as follows; activated lymphocytic supernatant from a H.T. and normal control were co-cultured with a cell line derived from normal thyroid (Nthy-ori and also a cell line derived from a papillary thyroid carcinoma that endogenously expresses ret/PTC-1 (TPC-1. The co-cultures were harvested at 0, 6 and 18 hour time points. Gene expression analysis was performed on RNA extracted from thyrocytes using TaqMan® Immune profiling Low-Density Arrays (Applied Biosystems, CA, USA comprising gene expression markers for 93 immune related targets plus 3 endogenous controls. Stimulation of the normal thyroid cell line model with activated T cell supernatant from the H.T. donor yielded global up-regulation of immune targets when compared with control supernatant stimulation. In particular, a cohort of targets (granzyme B, CD3, CD25, CD152, CD45 associated with cytotoxic cell death; T cell receptor (TCR and T cell signaling were up-regulated in the normal cell line model. When the ret/PTC-1 expressing thyroid cell line was co-cultured with H.T. lymphocyte supernatant, in comparison to control supernatant stimulation, down-regulation of the same subset of immune targets was seen. Conclusion Co-culturing H.T. lymphocyte supernatant with a normal thyroid cell line model leads to over-expression of a subset of targets which could contribute to the pathogenesis of H

  10. Substrate heater for the growth of epitaxial silicon films

    Science.gov (United States)

    Deming, Matthew; Varhue, Walter; Adams, Edward; Lavoie, Mark

    1999-03-01

    The single wafer processing of epitaxial Si films requires that special attention be paid to the design of the substrate heater assembly. This document describes the evolution and testing of an in situ heater used to deposit epitaxial Si films at temperatures as high as 700 °C. One problem encountered was the production of excessive levels of ultraviolet radiation which contributed to the desorption of water vapor from the vacuum chamber walls during the in situ cleaning process. A second problem involved the formation of a molybdenum containing film that poisoned epitaxial growth. A final proven in situ heater design is presented which avoids these problems.

  11. [The correlation between BRAF mutations, RET/PTC rearrangements and platelet-derived growth factor B expression in papillary thyroid carcinomas].

    Science.gov (United States)

    Wang, Ping; Wang, Yan-gang; Zhao, Wen-juan; Fu, Yu-dong; Wang, Luan; Wang, Fang; Zhao, Shi-hua

    2012-12-01

    To investigate the prevalence of BRAF T1799A mutation and RET/PTC rearrangement in Qingdao and detect the expression of platelet-derived growth factor B (PDGF-B) in order to investigate the correlation between gene mutation and PDGF-B. Fresh tissue from 48 papillary thyroid carcinomas (PTC) patients was examined for BRAF mutation RET rearrangements (RET/PTC1 and RET/PTC3) by PCR, followed by direct-sequence analysis. The expression of PDGF was analyzed by immunohistochemistry. Among the 48 patients, 14 (29.2%) were micro PTC; 18 (37.5%) had BRAF T1799A mutations and 23(47.9%) had RET/PTC rearrangement. There were 17 (35.4%) cases of RET/PTC1 and 6 (12.5%) of RET/PTC3, with no multiple rearrangements. Both BRAF T1799A mutation and RET/PTC rearrangement were present in 6 (12.5%) cases of non-micro PTC. The level of PDGF-B expression in BRAF T1799A positive was higher than that in the negative, and the level of PDGF-B expression in RET/PTC3 was higher than that in RET/PTC1 (P PTC rearrangement is higher in Qingdao. BRAF T1799A mutation and RET/PTC3 rearrangement in patients suggests a poorer prognosis than the negative one. The BRAF T1799A mutation and RET/PTC3 rearrangement may strengthen the expression of PDGF-B. Both variations suggest a poor prognosis.

  12. Solar-Powered Cooler and Heater for an Automobile Interior

    Science.gov (United States)

    Howard, Richard T.

    2006-01-01

    The apparatus would include a solar photovoltaic panel mounted on the roof and a panellike assembly mounted in a window opening. The window-mounted assembly would include a stack of thermoelectric devices sandwiched between two heat sinks. A fan would circulate interior air over one heat sink. Another fan would circulate exterior air over the other heat sink. The fans and the thermoelectric devices would be powered by the solar photovoltaic panel. By means of a double-pole, double-throw switch, the panel voltage fed to the thermoelectric stack would be set to the desired polarity: For cooling operation, the chosen polarity would be one in which the thermoelectric devices transport heat from the inside heat sink to the outside one; for heating operation, the opposite polarity would be chosen. Because thermoelectric devices are more efficient in heating than in cooling, this apparatus would be more effective as a heater than as a cooler. However, if the apparatus were to include means to circulate air between the outside and the inside without opening the windows, then its effectiveness as a cooler in a hot, sunny location would be increased.

  13. 75 FR 52892 - Energy Conservation Program for Consumer Products: Test Procedures for Residential Water Heaters...

    Science.gov (United States)

    2010-08-30

    ... discretion, this direct measurement procedure is optional for vented heaters without thermal stack dampers... efficiency is calculated for vented heaters with manual controls and thermal dampers. For all other vented... Procedures for Residential Water Heaters, Direct Heating Equipment, and Pool Heaters AGENCY: Office of...

  14. 78 FR 2340 - Energy Conservation Program: Test Procedures for Residential Water Heaters and Commercial Water...

    Science.gov (United States)

    2013-01-11

    ... also questionable whether thermal efficiency is an appropriate metric for smaller storage water heaters... that the test procedure for residential water heaters utilized the thermal efficiency and standby loss..., particularly for heat pump water heaters and gas instantaneous water heaters. 3. Revised Thermal Efficiency...

  15. 75 FR 20111 - Energy Conservation Program: Energy Conservation Standards for Residential Water Heaters, Direct...

    Science.gov (United States)

    2010-04-16

    ... 46,000 65 Table II.3--Current Federal Energy Conservation Standards for Pool Heaters Thermal efficiency as of Product class January 1, 1990 Gas-Fired Pool Heater Thermal Efficiency = 78% ] 2. History of... Heaters, Direct Heating Equipment, and Pool Heaters; Final Rule #0;#0;Federal Register / Vol. 75, No....

  16. 76 FR 56347 - Energy Conservation Program for Consumer Products: Test Procedures for Residential Water Heaters...

    Science.gov (United States)

    2011-09-13

    ... of the pool heater as: E OUT = BOH Where: BOH = as defined in 5.2 of this appendix E t = thermal... defined in 5.3 of this appendix 5.4.3 Calculate the pool heater integrated thermal efficiency (TE I ) (in... Residential Water Heaters, Direct Heating Equipment, and Pool Heaters (Standby Mode and Off Mode)...

  17. Modeling heat transfer from quench protection heaters to superconducting cables in Nb3Sn magnets

    CERN Document Server

    Salmi, T; Caspi, S; Felice, H; Prestemon, S; Chlachidze, G; Kate, H H J ten

    2013-01-01

    We use a recently developed quench protection heater modeling tool for an analysis of heater delays in superconducting high-field Nb3Sn accelerator magnets. The results suggest that the calculated delays are consistent with experimental data, and show how the heater delay depends on the main heater design parameters.

  18. 40 CFR 279.23 - On-site burning in space heaters.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 26 2010-07-01 2010-07-01 false On-site burning in space heaters. 279... burning in space heaters. Generators may burn used oil in used oil-fired space heaters provided that: (a) The heater burns only used oil that the owner or operator generates or used oil received from...

  19. Synthesis and Reactions of Five-Membered Heterocycles Using Phase Transfer Catalyst (PTC Techniques

    Directory of Open Access Journals (Sweden)

    Ahmed M. El-Sayed

    2014-01-01

    Full Text Available Phase transfer catalysts (PTCs have been widely used for the synthesis of organic compounds particularly in both liquid-liquid and solid-liquid heterogeneous reaction mixtures. They are known to accelerate reaction rates by facilitating formation of interphase transfer of species and making reactions between reagents in two immiscible phases possible. Application of PTC instead of traditional technologies for industrial processes of organic synthesis provides substantial benefits for the environment. On the basis of numerous reports it is evident that phase-transfer catalysis is the most efficient way for generation and reactions of many active intermediates. In this review we report various uses of PTC in syntheses and reactions of five-membered heterocycles compounds and their multifused rings.

  20. Electrochemical characterisation of Pt/C suspensions for the reduction of oxygen

    Energy Technology Data Exchange (ETDEWEB)

    Benitez, R.; Chaparro, A.M.; Daza, L. [Dep. Combustibles Fosiles, CIEMAT, Av. Complutense, 22, 28040 Madrid (Spain)

    2005-10-10

    Electrodes based on carbon-supported platinum electrocatalysts (Pt/C) have been studied in aqueous electrolyte electrochemical cells. The electrodes are prepared from suspensions of commercial Pt/C catalyst, deposited onto a carbon-covered Pt disk. Three deposition methods have been used, impregnation, spray and electrospray. The utilisation of Pt, i.e. the amount of Pt that really participates in the electrochemical reaction, was determined for each preparation method from measurements of the mass of Pt deposited on the electrode, and of the electroactive area of Pt. Higher utilisation rates are found on electrodes prepared by the impregnation method. The activity towards oxygen reduction in aqueous electrolyte was studied with the rotating electrode at different temperatures. (author)

  1. A PTC Optimization and Control Surface Interference Study HSR Airframe Technical Review

    Science.gov (United States)

    Hicks, Raymond; Cliff, Susan; Rimlinger, Mark; Murman, Scott; Reuther, James

    1999-01-01

    This report considers the effect of canard and horizontal tail vertical position on the aerodynamic characteristics of the PTC configuration without nacelles and diverters. This analysis is followed by three optimization studies using canard and tail incidence as design variables in the first problem followed by an optimization run with canard and tail incidence and wing camber design variables and finally an optimization run with canard incidence and wing camber. The first problem was run at fixed lift while the other two problems were run at fixed angle of attack. The final investigation reported here will show data from a component buildup study using the PTC configuration. This final study will show the aerodynamic interference between the canard, wing and horizontal tail.

  2. Ultrasound assisted PTC catalyzed saponification of vegetable oils using aqueous alkali.

    Science.gov (United States)

    Bhatkhande, B S; Samant, S D

    1998-03-01

    A few vegetable oils were saponified using aqueous KOH and different PTCs at room temperature in the presence of ultrasound. The extent of saponification was studied using the saponification value as a reference. Optimizations of various parameters such as time, selection of PTC, quantity of PTC, quantity of KOH and quantity of water were carried out using soyabean oil as a sample oil under sonication with stirring. To study the effect of ultrasound, the saponification was also carried out at 35 +/- 2 degrees C under different conditions, namely stirring, sonication, stirring and sonication, and heating at 100 degrees C. It was found that the heterogeneous liquid-liquid phase saponification of different vegetable oils using aq. KOH/CTAB was remarkably accelerated at 35 +/- 2 degrees C in the presence of ultrasound along with stirring.

  3. Fabrication and Characterization of High-activity Pt/C Electrocatalysts for Oxygen Reduction

    Energy Technology Data Exchange (ETDEWEB)

    Lim, Borami; Kim, Joung Woon; Hwang, Seung Jun; Yoo, Sung Jong; Cho, Eun Ae; Lim, Tae Hoon; Kim, Soo Kil [Korea Institute of Science and Technology, Seoul (Korea, Republic of)

    2010-06-15

    A 20 wt % Pt/C is fabricated and characterized for use as the cathode catalyst in a polymer electrolyte membrane fuel cell (PEMFC). By using the polyol method, the fabrication process is optimized by modifying the carbon addition sequence and precursor mixing conditions. The crystallographic structure, particle size, dispersion, and activity toward oxygen reduction of the as-prepared catalysts are compared with those of commercial Pt/C catalysts. The most effective catalyst is obtained by ultrasonic treatment of ethylene glycol-carbon mixture and immediate mixing of this mixture with a Pt precursor at the beginning of the synthesis. The catalyst exhibits very uniform particle size distribution without agglomeration. The mass activities of the as-prepared catalyst are 13.4 mA/mgPt and 51.0 mA/mgPt at 0.9 V and 0.85 V, respectively, which are about 1.7 times higher than those of commercial catalysts.

  4. Analytical Model for Ring Heater Thermal Compensation in Advanced LIGO

    CERN Document Server

    Ramette, Joshua; Brooks, Aidan; Blair, Carl; Wang, Haoyu; Heintze, Matthew

    2015-01-01

    Advanced laser interferometer gravitational-wave detectors use high laser power to achieve design sensitivity. A small part of this power is absorbed in the interferometer cavity mirrors where it creates thermal lenses, causing aberrations in the main laser beam that must be minimized by the actuation of "ring heaters," additional heater elements that are aimed to reduce the temperature gradients in the mirrors. In this article we derive the first analytical model of the temperature field generated by an ideal ring heater. We express the resulting optical aberration contribution to the main laser beam in this axisymmetric case. Used in conjunction with wavefront measurements, our model provides a more complete understanding of the thermal state of the cavity mirrors and will allow a more efficient use of the ring heaters in Advanced LIGO.

  5. ENERGY STAR Certified Water Heaters (V3.1)

    Data.gov (United States)

    U.S. Environmental Protection Agency — Certified models meet all ENERGY STAR requirements as listed in the Version 3.0 ENERGY STAR Program Requirements for Water Heaters that are effective April 16, 2015....

  6. A High Performance Cathode Heater for Hall Thrusters Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The current state-of-the-art co-axial swaged tantalum (Ta) heaters use magnesium oxide (MgO) insulators, which limits their operation to temperatures well below...

  7. New Home Buyer Solar Water Heater Trade-Off Study

    Energy Technology Data Exchange (ETDEWEB)

    Symmetrics Marketing Corporation

    1999-08-18

    This report details the results of a research conducted in 1998 and 1999 and outlines a marketing deployment plan designed for businesses interested in marketing solar water heaters in the new home industry.

  8. Materials for damping the PTC-induced thermal fluctuations of the cold-head

    Science.gov (United States)

    Catarino, I.; Martins, D.; Sudiwala, R.

    2015-12-01

    The cold head on mechanical Pulse Tube Cryocoolers (PTCs) is subject to substantially less mechanical vibration and electromagnetic interference compared to that typically found in Gifford MacMahon coolers. However, thermal fluctuations at the PTC frequency are still present at the cold-head, typically at a level of 200 mK peak-to-peak at 1.4 Hz for a Cryomech Model PT405 cooler running at 4 K. It is highly desirable to damp out these fluctuations if PTCs are to be used successfully for running systems sensitive to such thermal fluctuations, for example, bolometeric detectors. We report here the characterization over the temperature range 2.5 K to 6 K of two materials, GOS (Gd2O2S) and GAP (GdAlO3), for use as low-pass thermal filters. These materials have antiferromagnetic transitions at around 4 K giving rise to an enhanced heat capacity and have a high thermal conductance. These are two highly desirable properties for thermal dampers in this application. Those materials were fired as ceramic discs to be tested as thermal dumpers. Thermal filter assemblies with discs of diameter 75 mm and thickness 2.5 mm and 1.6 mm (GOS and GAP, respectively) mounted in a PTC show thermal attenuation levels of x0.12 (GOS) and x0.11 (GAP) at 0.01Hz with a clean-side temperature of 4 K; the PTC induced fluctuations at 1.48 Hz are damped completely to within the noise limits (0.2 mK) of the thermometers. Experimentally determined thermal conductance and heat capacity data are reported. For this system, with a PTC cold-head (dirty-side) temperature of 3.3 K, a clean-side power dissipation of up to 30 mW is realized before its temperature rises above 4.2 K.

  9. RNA sequencing identifies crucial genes in papillary thyroid carcinoma (PTC) progression.

    Science.gov (United States)

    Qiu, Jie; Zhang, Wenwei; Xia, Qingsheng; Liu, Fuxue; Li, Li; Zhao, Shuwei; Gao, Xian; Zang, Chuanshan; Ge, Ruifeng; Sun, Yan

    2016-02-01

    The study aims to uncover molecular mechanisms of PTC (papillary thyroid carcinoma) progression and provide therapeutic biomarkers. The paired tumor and control tissues were obtained from 5 PTC patients. RNA was extracted and cDNA libraries were constructed. RNA-sequencing (RNA-seq) was performed on the Illumina HiSeq2000 platform using paired-end method. After preprocessing of the RNA-seq data, gene expression value was calculated by RPKM. Then the differentially expressed genes (DEGs) were identified with edgeR. Functional enrichment and protein-protein interaction (PPI) network analyses were conducted for the DEGs. Module analysis of the PPI network was also performed. Transcription factors (TFs) of DEGs were predicted. A cohort of 496 up-regulated DEGs mainly correlating with the ECM degradation pathways, and 440 down-regulated DEGs predominantly enriching in transmembrane transport process were identified. Hub nodes in the PPI network were RRM2 and a set of collagens (COL1A1, COL3A1 and COL5A1), which were also remarkable in module 3 and module 5, respectively. Genes in module 3 were associated with cell cycle pathways, while in module 5 were related to ECM degradation pathways. PLAU, PSG1 and EGR2 were the crucial TFs with higher transcriptional activity in PTC than in control. Several genes including COL1A1, COL3A1, RRM2, PLAU, and EGR2 might be used as biomarkers of PTC therapy. Among them, COL1A1 and COL3A1 might exert their functions via involving in ECM degradation pathway, while RRM2 through cell cycle pathway. PLAU might be an active TF, whereas EGR2 might be a tumor suppressor. Copyright © 2015 Elsevier Inc. All rights reserved.

  10. Electrochemical Behavior of Mitoxantrone and Its Determination at a Pt/C Implanted Modified Microelectrode

    Institute of Scientific and Technical Information of China (English)

    QIAN Yong-gui; SUN Zi-jie; HU Jing-bo; LU Yi-qiang; LI Qi-long

    2004-01-01

    In a 0.02 mol/L Na2HPO4-KH2PO4(PBS) buffer solution(pH=6.82), the electrochemical behavior of mitoxantrone was studied by linear-sweep voltammetry and cyclic voltammetry at a Pt/C ion implantation modified microelectrode. A sensitive reduction peak was observed. The peak potential was -0.72 V(vs.SCE), the peak current was proportional to the concentration of mitoxantrone within the ranges of 7.0×10-8-9.0×10-7 mol/L and 1.0×10-6-2.4×10-5 mol/L, with a detection limit of 4.0×10-8 mol/L. The linear correlation coefficients were 0.9994 and 0.9992, respectively. This method has been applied to the direct determination of mitoxantrone in simulated urine. The recoveries were in the range from 96.2% to 105.9%. The reduction process was a quasi-reversible one with adsorptive characteristics at the Pt/C microelectrode. The electrode reaction rate constant ks and the electron transfer coefficient α of the system were determined to be 4.5 and 0.65 s-1, respectively. The experiments showed that Pt element had surely been implanted into the surface of the carbon fiber, and the atomic Pt improved the electrocatalytic activity. The Pt/C microelectrode had a good stability and reproducibility.

  11. Polyol synthesis of nanosized Pt/C electrocatalysts assisted by pulse microwave activation

    Energy Technology Data Exchange (ETDEWEB)

    Lebegue, E.; Baranton, S.; Coutanceau, C. [Laboratoire de Catalyse en Chimie Organique (LACCO), UMR 6503 CNRS, Universite de Poitiers, 40 av recteur Pineau, F-86000 Poitiers (France)

    2011-02-01

    A polyol process assisted by pulse microwave activation was used to prepare efficient Pt/C electrocatalysts for PEMFC applications with reducing cost. Catalysts from pulsed microwave method were compared with a catalyst issued from a classical method, in terms of active surface area, platinum loading and activity towards the oxygen reduction reaction. A design of experiments (DOE derived from the Taguchi method) has been implemented to optimize experimental parameters only related to pulse microwave activation, the intrinsic synthesis parameters (concentration of platinum salt, platinum/carbon weight ratio and pH) being kept constant. Controlled parameters were duration of microwave pulse, maximum temperature and total duration of the synthesis. Considered responses were catalyst active surface area and the Pt/C loading. An optimized configuration of synthesis parameter was proposed. The confirmation experiment revealed a trend in agreement with that expected. Three catalysts (two from pulsed microwave synthesis method and one prepared by the classical method) were characterized by transmission electron microscopy, cyclic voltammetry and CO stripping. Catalysts from pulsed microwave method display higher characteristics than the one prepared by the classical method. The Pt/C catalyst from the confirmation experiment displays the highest catalytic activity toward oxygen reduction reaction. (author)

  12. Temperature limited heater utilizing non-ferromagnetic conductor

    Energy Technology Data Exchange (ETDEWEB)

    Vinegar,; Harold J. (Bellaire, TX), Harris; Kelvin, Christopher [Houston, TX

    2012-07-17

    A heater is described. The heater includes a ferromagnetic conductor and an electrical conductor electrically coupled to the ferromagnetic conductor. The ferromagnetic conductor is positioned relative to the electrical conductor such that an electromagnetic field produced by time-varying current flow in the ferromagnetic conductor confines a majority of the flow of the electrical current to the electrical conductor at temperatures below or near a selected temperature.

  13. Thermal performance of a new solar air heater

    Energy Technology Data Exchange (ETDEWEB)

    Tiris, C.; Ozbalta, N. [Ege Univ., Izmir (Turkey). Solar Energy Institute; Tiris, M.; Dincer, I. [TUBITAK-Marmara Research Center, Kocaeli (Turkey)

    1995-05-01

    A solar air heater, part of a food drying system using solar energy as a renewable energy source for heat, was developed and tested for several agricultural products (i.e., sultana grapes, green beans, sweet peppers, chili peppers). Drying processes were conducted in the chamber with forced natural air heated partly by solar energy. Solar air heater performances were discussed along with estimates of energy efficiency of the system. The obtained results indicate that the present system is efficiency and effective.

  14. Mathematical modeling of the area of tubular gas heater in the condensing mode of work

    OpenAIRE

    IRODOV V. F.; Bereziuk, G. G.

    2015-01-01

    Statement of the problem. Infrared tubular gas heaters are designed for burning gas, moving of the heated products of combustion with air inside the tubular heater and heating of the room where the heater is installed with the help of radiant and convective heat exchange with space of the room. Tubular gas heaters are simultaneously sources of heat supply and heating devices. Using of these heaters provides fuel economy and uniform distribution of comfortable heat. Maximum fuel economy can be...

  15. Expression of the RET/PTC fusion gene as a marker for papillary carcinoma in Hashimoto's thyroiditis

    DEFF Research Database (Denmark)

    Wirtschafter, A; Schmidt, R; Rosen, D

    1997-01-01

    -polymerase chain reaction (RT-PCR) assay, we found messenger RNA (mRNA) expression for the RET/PTC1 and RET/PTC3 oncogenes in 95% of the Hashimoto's patients studied. All Hashimoto's patients presenting without histopathologic evidence of papillary thyroid cancer showed molecular genetic evidence of cancer......Hashimoto's thyroiditis is an inflammatory disease of the thyroid gland with autoimmune etiology. Patients afflicted with Hashimoto's have a higher risk of thyroid malignancies such as papillary thyroid carcinoma. In the present study, we investigated the frequency of papillary thyroid carcinoma...... specific genes in patients diagnosed with Hashimoto's disease. The newly identified oncogenes RET/PTC1 and RET/PTC3 provide useful and specific markers of the early stages of papillary carcinoma as they are highly specific for malignant cells. Using a sensitive and specific reverse transcriptase...

  16. PAX8/PPARG and RET/PTC rearrangement detection is feasible in routine air dried fine needle aspiration (FNA) smears

    DEFF Research Database (Denmark)

    Ferraz, Carolina; Rehfeld, Christian; Krogdahl, Annelise;

    2012-01-01

    Background: The diagnostic limitations of fine needle aspiration (FNA), like the "indeterminate" category, can be partially overcome by molecular analysis. As PAX8/PPARG and RET/PTC rearrangements have been detected in follicular carcinomas (FTC) and papillary carcinomas (PTC), their detection...... as generally not suitable for testing these rearrangements in a clinical setting. Therefore, the objective of the present study was to investigate the feasibility of extracting RNA from routine-air-dried FNA smears for the detection of these rearrangements with RT-PCR. Methods: A new method for RNA extraction......). Similarly, RET/PTC was found in 3 of 96 FFPEs and in 4 of 96 FNAs. Two of 21 PTC samples and 3 of 42 FA samples carried this rearrangement. Conclusion: These data are the first to show the feasibility of extracting RNA from routine air dried FNA smears for the detection of PAX8/PPARG and RET...

  17. Gravity and Heater Size Effects on Pool Boiling Heat Transfer

    Science.gov (United States)

    Kim, Jungho; Raj, Rishi

    2014-01-01

    The current work is based on observations of boiling heat transfer over a continuous range of gravity levels between 0g to 1.8g and varying heater sizes with a fluorinert as the test liquid (FC-72/n-perfluorohexane). Variable gravity pool boiling heat transfer measurements over a wide range of gravity levels were made during parabolic flight campaigns as well as onboard the International Space Station. For large heaters and-or higher gravity conditions, buoyancy dominated boiling and heat transfer results were heater size independent. The power law coefficient for gravity in the heat transfer equation was found to be a function of wall temperature under these conditions. Under low gravity conditions and-or for smaller heaters, surface tension forces dominated and heat transfer results were heater size dependent. A pool boiling regime map differentiating buoyancy and surface tension dominated regimes was developed along with a unified framework that allowed for scaling of pool boiling over a wide range of gravity levels and heater sizes. The scaling laws developed in this study are expected to allow performance quantification of phase change based technologies under variable gravity environments eventually leading to their implementation in space based applications.

  18. A type 2C protein phosphatase FgPtc3 is involved in cell wall integrity, lipid metabolism, and virulence in Fusarium graminearum.

    Directory of Open Access Journals (Sweden)

    Jinhua Jiang

    Full Text Available Type 2C protein phosphatases (PP2Cs play important roles in regulating many biological processes in eukaryotes. Currently, little is known about functions of PP2Cs in filamentous fungi. The causal agent of wheat head blight, Fusarium graminearum, contains seven putative PP2C genes, FgPTC1, -3, -5, -5R, -6, -7 and -7R. In order to investigate roles of these PP2Cs, we constructed deletion mutants for all seven PP2C genes in this study. The FgPTC3 deletion mutant (ΔFgPtc3-8 exhibited reduced aerial hyphae formation and deoxynivalenol (DON production, but increased production of conidia. The mutant showed increased resistance to osmotic stress and cell wall-damaging agents on potato dextrose agar plates. Pathogencity assays showed that ΔFgPtc3-8 is unable to infect flowering wheat head. All of the defects were restored when ΔFgPtc3-8 was complemented with the wild-type FgPTC3 gene. Additionally, the FgPTC3 partially rescued growth defect of a yeast PTC1 deletion mutant under various stress conditions. Ultrastructural and histochemical analyses showed that conidia of ΔFgPtc3-8 contained an unusually high number of large lipid droplets. Furthermore, the mutant accumulated a higher basal level of glycerol than the wild-type progenitor. Quantitative real-time PCR assays showed that basal expression of FgOS2, FgSLT2 and FgMKK1 in the mutant was significantly higher than that in the wild-type strain. Serial analysis of gene expression in ΔFgPtc3-8 revealed that FgPTC3 is associated with various metabolic pathways. In contrast to the FgPTC3 mutant, the deletion mutants of FgPTC1, FgPTC5, FgPTC5R, FgPTC6, FgPTC7 or FgPTC7R did not show aberrant phenotypic features when grown on PDA medium or inoculated on wheat head. These results indicate FgPtc3 is the key PP2C that plays a critical role in a variety of cellular and biological functions, including cell wall integrity, lipid and secondary metabolisms, and virulence in F. graminearum.

  19. Thermo-Electron Ballistic Coolers or Heaters

    Science.gov (United States)

    Choi, Sang H.

    2003-01-01

    Electronic heat-transfer devices of a proposed type would exploit some of the quantum-wire-like, pseudo-superconducting properties of single-wall carbon nanotubes or, optionally, room-temperature-superconducting polymers (RTSPs). The devices are denoted thermo-electron ballistic (TEB) coolers or heaters because one of the properties that they exploit is the totally or nearly ballistic (dissipation or scattering free) transport of electrons. This property is observed in RTSPs and carbon nanotubes that are free of material and geometric defects, except under conditions in which oscillatory electron motions become coupled with vibrations of the nanotubes. Another relevant property is the high number density of electrons passing through carbon nanotubes -- sufficient to sustain electron current densities as large as 100 MA/square cm. The combination of ballistic motion and large current density should make it possible for TEB devices to operate at low applied potentials while pumping heat at rates several orders of magnitude greater than those of thermoelectric devices. It may also enable them to operate with efficiency close to the Carnot limit. In addition, the proposed TEB devices are expected to operate over a wider temperature range

  20. [RET/PTC Gene Rearrangements in the Sporadic and Radiogenic Thyroid Tumors: Molecular Genetics, Radiobiology and Molecular Epidemiology].

    Science.gov (United States)

    Ushenkova, L N; Koterov, A N; Biryukov, A P

    2015-01-01

    A review of molecular genetic, radiobiological and molecular epidemiological studies of gene (chromosome) rearrangements RET/PTC in the cells of the thyroid gland as well as the laws in relation to radiation exposure in vitro, in vivo and human populations identified with them are submitted. The data on the c-RET gene and its chimeric constructs with the gene-donors (RET/PTC rearrangements) are considered. The information about the history of the RET/PTC discovery, their types, carcinogenic potential and specificity both to tumor and non-tumor thyroid disease especially for papillary thyroid carcinoma are provided. The data (seven studies) on the induction of RET/PTC after irradiation of tumor and normal thyroid cells in vitro and mice are reviewed. The mechanisms of RET/PTC induction may be associated with DNA double strand breaks and oxidative stress. Some information (three publications) about the possibility of RET/PTC induction by low doses of radiation with low LET (to 0.1 Gy) is given and it is concluded that their potential evidentiary is generally weak. The achievements in the molecular epidemiology of RET/PTC frequency for exposed and unexposed cohorts are stated. At the same time it is noted that, despite the vast array. of data accumulated from 30 countries of the world and more than 20 years of research, the formed provisions are weakly confirmed statistically and have no base corresponding to the canons of evidence-based medicine. The possibility of use of the RET/PTC presence or their frequencies as markers of the papillary thyroid carcinomas and, specifically, their radiogenic forms, is considered. In the first case the answer may be positive, while in the second, the situation is characterized by uncertainty. Based to the above mentioned we came to a conclusion about the need of a pooled or meta-analysis of the totality of the published data.

  1. The electrocatalytic properties of carbon supported PtRu/C nanoalloys in oxidation of small organic molecules: Comparison with Pt/C catalyst

    Directory of Open Access Journals (Sweden)

    Lović Jelena D.

    2012-01-01

    Full Text Available The electrocatalytic activity of carbon supported PtRu/C catalysts, with different composition, toward the electrooxidation of methanol, CO and formic acid were examined in acid and alkaline solution at ambient temperature using thin-film rotating disk electrode (RDE method and compared with activity of Pt/C. The catalysts were characterized by XRD, AFM and STM techniques. XRD pattern revealed that PtRu-1/C catalyst is consisted of two structures e.g. Pt-Ru-fcc and Ru-hcp (the solid solution of Ru in Pt and the small amount of Ru or solid solution of Pt in Ru, as opposed to PtRu-2/C catalyst which is consisted of one structure mostly, Pt-Ru-fcc. According to STM images, PtRu as well as Pt, particles size were between 2 and 6 nm, which is in a good agreement with the mean particles size determined by XRD. To establish the activity and stability of the catalysts potentiodynamic and quasi steady-state measurements were performed. It was found that the activity of Pt and PtRu for CO and methanol oxidation is a strong function of pH of solution. The kinetics are much higher in alkaline than in acid solution and the difference between Pt/C and PtRu/C is much less pronounced in alkaline media. Results presented in this work indicate that activity of PtRu catalysts depends on catalyst composition, e.g. on Pt/Ru atomic ratio, as well as on alloying degree of catalysts. Comparison of CO, methanol and formic acid oxidation on PtRu-2/C, PtRu-1/C and Pt/C catalysts revealed that PtRu-2/C is the most active one. It was shown that the PtRu-2/C catalyst, due to fact that it is consisted of only one phase, with high alloying degree, through the bifunctional mechanism improved by electronic effect, achieve the activity two times higher related to PtRu-1/C in the oxidation of all organic molecules investigated, and about three times higher compared to Pt/C in the oxidation of methanol and CO, and five times higher in formic acid oxidation.

  2. Heater induced thermal effects on the LTP dynamics

    CERN Document Server

    Gibert, Ferran; Lobo, Alberto; Díaz-Aguiló, Marc; Mateos, Ignacio; Karnesis, Nikolaos; Sanjuán, Josep; Gesa, Lluís; lloro, Ivan; Martín, Víctor

    2013-01-01

    The STOC (Science and Technology Operations Centre) simulator of the LPF (LISA PathFinder) mission is intended to provide a validation tool for the mission operations tele-commanding chain, as well as for a deeper understanding of the underlying physical processes happening in the LTP (LISA Technology Package). Amongst the different physical effects that will appear onboard, temperature fluctuations in the Electrode Housing (EH) could generate disturbances on the interferometer (IFO) readouts, therefore they must be known and controlled. In this article we report on the latest progress in the analysis at IEEC of the LTP response to thermal signals injected by means of heaters. More specifically, we determine the transfer functions relating heat input signals to forces on the Test Masses (TMs) in the LTP frequency band, from 1 mHz to 30 mHz. A complete thermal model of the entire LPF spacecraft plus payload, elaborated and maintained at European Space Technology Center (ESTEC), was used to obtain temperature d...

  3. ASME power test code ptc 4.1 for steam generators; Codigo de pruebas de potencia ASME ptc 4.1 para generadores de vapor

    Energy Technology Data Exchange (ETDEWEB)

    Plauchu Alcantara, Jorge Alberto [Plauchu Consultores, Morelia, Michoacan (Mexico)

    2001-07-01

    This presentation is oriented towards those who in this subject have experience in the design and equipment specification, plant projects, factory and field testing, operation or result analyses. An important fraction of the national energy supply, approximately 13%, is applied to the steam generation in the different aspects of the industrial activity, in the electrical industry of public service and in the commercial and services sector. The development of the national programs of energy efficiency verifies this when dedicating to this use of the energy important projects, some of them with support of the USAID. The measurement of the energy utilization or the efficiency of steam generators (or boilers) is made applying some procedure agreed by the parts and the one of greater acceptance and best known in Mexico and internationally is the ASME Power Test Code PTC 4.1 for Steam Generators. The purpose and formality in the determination of efficiency and of steam generation capacity behavior, thermal basic regime or fulfillment of guarantees, radically changes the exigencies of strict attachment to the PTC 4.1 This definition will determine the importance of the test method selected, the deviations and convened exceptions, the influence of the precision and the measurement errors, the consideration of auxiliary equipment, etc. An interpretation or incorrect application of the Test Code has lead and will lead to results and nonreliable decisions. [Spanish] Esta exposicion se orienta a quienes en este tema cuenta con experiencia en diseno y especificacion de equipo, proyecto de planta, pruebas en fabrica y campo, operacion o analisis de resultados. Una fraccion importante de la oferta nacional de energia, 13% aproximadamente, se aplica a la generacion de vapor en diferentes giros de actividad industrial, en la industria electrica, de servicio publico y en el sector de servicios y comercial. El desarrollo de los programas nacionales de eficiencia energetica comprueba

  4. Combustion-Driven Oscillation in Process Heaters

    Energy Technology Data Exchange (ETDEWEB)

    Seebold, J.G. [Chevron Corporation (Retired), 198 James Avenue, Atherton, CA 94027 (United States)

    2005-10-15

    At this moment in thousands of process heaters all over the world there are, to borrow a phrase from the late Carl Sagan, 'billions and billions' of Btu/hr beneficially being released entirely free of pulsation. On those few occasions, perhaps a dozen and a half in my career, when I would get the inevitable 'Why me?' call, I have generally responsed with something like, 'Consider yourself lucky, you have a rare scientific curiosity on your hands'. Reflecting on the solutions ultimately found, I'm reminded that many years ago my friend Abbott Putnam shared with me an early AGA (American Gas Association) field-service bulletin that included a prescription for eliminating combustion-driven oscillations in home heating units; viz., 'Drill a hole; if that doesn't work, drill another hole' or words to that effect. Many times have I wished that I still had a copy of that bulletin and in this paper we will have occasion, once again, to reflect upon the value of that advice. In this paper we will discuss an instance that arose in a pioneering installation of a breakthrough development of 'extremely', to distinguish it from 'ultra', low-NOx lean premix burner technology. We will illustrate how, when and under what circumstances combustion-driven oscillation can arise; we will touch on the many alternatives for its elimination that were considered and investigated; and we will discuss three practical alternatives for eliminating combustion-driven oscillations.

  5. Multifamily Heat Pump Water Heater Evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Hoeschele, M. [Davis Energy Group, Davis, CA (United States). Alliance for Residential Building Innovation; Weitzel, E. [Davis Energy Group, Davis, CA (United States). Alliance for Residential Building Innovation

    2017-03-03

    Although heat pump water heaters (HPWHs) have gained significant attention in recent years as a high efficiency electric water heating solution for single family homes, central HPWHs for commercial or multi-family applications are not as well documented in terms of measured performance and cost effectiveness. To evaluate this technology, the Alliance for Residential Building Innovation team monitored the performance of a 10.5 ton central HPWH installed on a student apartment building at the West Village Zero Net Energy Community in Davis, California. Monitoring data collected over a 16 month period were then used to validate a TRNSYS simulation model. The TRNSYS model was then used to project performance in different climates using local electric rates. Results of the study indicate that after some initial commissioning issues, the HPWH operated reliably with an annual average efficiency of 2.12 (Coefficient of Performance). The observed efficiency was lower than the unit's rated efficiency, primarily due to the fact that the system rarely operated under steady-state conditions. Changes in the system configuration, storage tank sizing, and control settings would likely improve the observed field efficiency. Modeling results suggest significant energy savings relative to electric storage water heating systems (typical annual efficiencies around 0.90) providing for typical simple paybacks of six to ten years without any incentives. The economics versus gas water heating are currently much more challenging given the current low natural gas prices in much of the country. Increased market size for this technology would benefit cost effectiveness and spur greater technology innovation.

  6. Multifamily Heat Pump Water Heater Evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Hoeschele, M. [Alliance for Residential Building Innovation (ARBI), Davis, CA (United States); Weitzel, E. [Alliance for Residential Building Innovation (ARBI), Davis, CA (United States)

    2013-11-22

    Although heat pump water heaters (HPWHs) have gained significant attention in recent years as a high efficiency electric water heating solution for single family homes, central HPWHs for commercial or multi-family applications are not as well documented in terms of measured performance and cost effectiveness. To evaluate this technology, the Alliance for Residential Building Innovation team monitored the performance of a 10.5 ton central HPWH installed on a student apartment building at the West Village Zero Net Energy Community in Davis, California. Monitoring data collected over a 16 month period were then used to validate a TRNSYS simulation model. The TRNSYS model was then used to project performance in different climates using local electric rates. Results of the study indicate that after some initial commissioning issues, the HPWH operated reliably with an annual average efficiency of 2.12 (Coefficient of Performance). The observed efficiency was lower than the unit's rated efficiency, primarily due to the fact that the system rarely operated under steady-state conditions. Changes in the system configuration, storage tank sizing, and control settings would likely improve the observed field efficiency. Modeling results suggest significant energy savings relative to electric storage water heating systems (typical annual efficiencies around 0.90) providing for typical simple paybacks of six to ten years without any incentives. The economics versus gas water heating are currently much more challenging given the current low natural gas prices in much of the country. Increased market size for this technology would benefit cost effectiveness and spur greater technology innovation.

  7. Multifamily Heat Pump Water Heater Evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Hoeschele, M. [Alliance for Residential Building Innovation (ARBI), Davis, CA (United States); Weitzel, E. [Alliance for Residential Building Innovation (ARBI), Davis, CA (United States)

    2017-03-01

    Although heat pump water heaters (HPWHs) have gained significant attention in recent years as a high efficiency electric water heating solution for single family homes, central HPWHs for commercial or multi-family applications are not as well documented in terms of measured performance and cost effectiveness. To evaluate this technology, the Alliance for Residential Building Innovation team monitored the performance of a 10.5 ton central HPWH installed on a student apartment building at the West Village Zero Net Energy Community in Davis, California. Monitoring data collected over a 16 month period were then used to validate a TRNSYS simulation model. The TRNSYS model was then used to project performance in different climates using local electric rates. Results of the study indicate that after some initial commissioning issues, the HPWH operated reliably with an annual average efficiency of 2.12 (Coefficient of Performance). The observed efficiency was lower than the unit's rated efficiency, primarily due to the fact that the system rarely operated under steady-state conditions. Changes in the system configuration, storage tank sizing, and control settings would likely improve the observed field efficiency. Modeling results suggest significant energy savings relative to electric storage water heating systems (typical annual efficiencies around 0.90) providing for typical simple paybacks of six to ten years without any incentives. The economics versus gas water heating are currently much more challenging given the current low natural gas prices in much of the country. Increased market size for this technology would benefit cost effectiveness and spur greater technology innovation.

  8. Comparative Study and Design of Solar Water Heater

    Directory of Open Access Journals (Sweden)

    K.Sainath,Y.krishna, Mohd Salahuddin, Mohammed Siddique Ahmed, Md Ismail, Syed Rahman,Mohammed Noman, Mohd Khaleel Ullah, Faraz Ur Rehman Azhar, Mohd Moizuddin,Mohd Riyaz Uddin.

    2014-10-01

    Full Text Available A solar water heater design is made from the plastic bottles of thumps up & plastic pipe(p.v.c run up by the centre of each solar heater in a row of bottles, these bottles act as glazing & hold reflectors made from the black paint. Solar water heaters are made of two basic parts: a solar collector that gathers radiant energy and a storage tank for the hot water inside. These systems are used to heat water for swimming pools, as well as for domestic cooking and cleaning needs. A system in which the sun’s heat is gathered by a solar collector and used to increase the temperature of a heat-transfer fluid , which flows through the pipes in the collector; the heat contained in this fluid then is conveyed and transferred to the water to be heated. Solar water heaters use the solar energy from the sun to generate heat (not electricity which can then be used to heat water for showering, space heating, industrial processes or even solar cooling. However, the research shows that the electric water spends about the 25% of its home energy costs on heating water. If we make a water heater without the collector then we can save a lot of money solar water heater do not polluted if one investing on SWH avoids carbon dioxide nitrogen oxide and sulphur dioxide and the other air pollution wastes and the utility generates power on your bum fuel to heat your household water when SWH replaces the an electric water heater. This electric displaced over 20 years replaced more than 50 tones avoided c02 emissions alone co2 traps heat in the upper most atmosphere thus, contributing to the ‘Green House Effect

  9. Engineering solutions for polymer composites solar water heaters production

    Science.gov (United States)

    Frid, S. E.; Arsatov, A. V.; Oshchepkov, M. Yu.

    2016-06-01

    Analysis of engineering solutions aimed at a considerable decrease of solar water heaters cost via the use of polymer composites in heaters construction and solar collector and heat storage integration into a single device representing an integrated unit results are considered. Possibilities of creating solar water heaters of only three components and changing welding, soldering, mechanical treatment, and assembly of a complicate construction for large components molding of polymer composites and their gluing are demonstrated. Materials of unit components and engineering solutions for their manufacturing are analyzed with consideration for construction requirements of solar water heaters. Optimal materials are fiber glass and carbon-filled plastics based on hot-cure thermosets, and an optimal molding technology is hot molding. It is necessary to manufacture the absorbing panel as corrugated and to use a special paint as its selective coating. Parameters of the unit have been optimized by calculation. Developed two-dimensional numerical model of the unit demonstrates good agreement with the experiment. Optimal ratio of daily load to receiving surface area of a solar water heater operating on a clear summer day in the midland of Russia is 130‒150 L/m2. Storage tank volume and load schedule have a slight effect on solar water heater output. A thermal insulation layer of 35‒40 mm is sufficient to provide an efficient thermal insulation of the back and side walls. An experimental model layout representing a solar water heater prototype of a prime cost of 70‒90/(m2 receiving surface) has been developed for a manufacturing volume of no less than 5000 pieces per year.

  10. RET/PTC1-Driven Neoplastic Transformation and Proinvasive Phenotype of Human Thyrocytes Involve Met Induction and β-Catenin Nuclear Translocation

    Directory of Open Access Journals (Sweden)

    Giuliana Cassinelli

    2009-01-01

    Full Text Available Activation of the RET gene by chromosomal rearrangements generating RET/PTC oncogenes is a frequent, early, and causative event in papillary thyroid carcinoma (PTC. We have previously shown that, in human primary thyrocytes, RET/PTC1 induces a transcriptional program including the MET proto-oncogene. In PTCs, β-catenin is frequently mislocated to the cytoplasm nucleus. We investigated the interplay between Ret/ptc1 signaling and Met in regulating the proinvasive phenotype and β-catenin localization in cellular models of human PTC. Here, we show that Met protein is expressed and is constitutively active in human thyrocytes exogenously expressing RET/PTC1 as well as a mutant (Y451F devoid of the main Ret/ptc1 multidocking site. Both in transformed thyrocytes and in the human PTC cell line TPC-1, Ret/ptc1-Y451-dependent signaling and Met cooperated to promote a proinvasive phenotype. Accordingly, gene/functional silencing of either RET/PTC1 or MET abrogated early branching morphogenesis in TPC-1 cells. The same effect was obtained by blocking the common downstream effector Akt. Y451 of Ret/ptc1 was required to promote proliferation and nuclear translocation of β-catenin, suggesting that these oncogene-driven effects are Met-independent. Pharmacologic inhibition of Ret/ptc1 and Met tyrosine kinases by the multitarget small molecule RPI-1 blocked cell proliferation and invasive ability and dislocated β-catenin from the nucleus. Altogether, these results support that Ret/ptc1 cross talks with Met at transcriptional and signaling levels and promotes β-catenin transcriptional activity to drive thyrocyte neoplastic transformation. Such molecular network, promoting disease initiation and acquisition of a proinvasive phenotype, highlights new options to design multitarget therapeutic strategies for PTCs.

  11. Estimation of thermophysical properties by an inverse method with experimentally determined heating region of a thin-layer heater

    Science.gov (United States)

    Zmywaczyk, J.; Madura, H.; Koniorczyk, P.; Dąbrowski, M.

    2007-01-01

    This paper deals with the problem of estimation of thermophysical parameters by an inverse method. The thermal conductivity in radial and axial direction of a cylindrical sample and the heat capacity were simultaneously estimated using the Levenberg-Marquardt method of minimizing a mean square functional. As heat sources the thin-layer heater KHR 2/10 of diameter ϕ = 50 mm and thickness 0.20 mm made by OMEGA as well as the Kanthal resistance wire of diameter ϕ = 0.1 mm in a form of semicircle were simultaneously used. The main aim of using these two heaters simultaneously, both placed at one of the sample interfaces, was to generate heat fluxes in axial and additionally in radial direction. However, measurements of temperature distribution on the main surface of the thin-layer heater by using the FLIR Systems (ThermaCAM SC 3000 infrared camera) revealed a spatial heterogeneity of its temperature field, and therefore it was necessary to determine the effective heating region of that heater indispensable for solving of the coefficient inverse problem of heat conduction.

  12. High TPOAb Levels (>1300 IU/mL) Indicate Multifocal PTC in Hashimoto's Thyroiditis Patients and Support Total Thyroidectomy.

    Science.gov (United States)

    Dong, Shuai; Xia, Qing; Wu, Yi-Jun

    2015-07-01

    We aimed to identify whether thyroid peroxidase antibodies (TPOAb) are indicative of multifocal papillary thyroid cancer (PTC) in Hashimoto's thyroiditis (HT) patients and may help to determine necessity for total thyroidectomy. Retrospective cohort study. Teaching hospital. A total of 808 consecutive patients with HT alone or with HT and unifocal or multifocal PTC were included. Preoperative thyroid function tests, TPOAb determination, preoperative ultrasonography, intraoperative frozen biopsy, and postoperative routine pathologic examination to confirm thyroid nodules were performed for all patients. Patients with nodules or malignancy potential on ultrasound and fine-needle aspiration cytology were included. Patients with hyperthyroidism, concomitant chronic disease, a history of other malignant tumors, or history of major diseases were excluded. All patients underwent surgery, and HT and PTC were confirmed by postoperative pathologic results. No significant differences were found in age and sex between groups (P > .05). TPOAb ≤1300 IU/mL were more prevalent in the HT + unifocal PTC group than in the other groups (99.57% vs 15.52% and 60.75%, P 1300 IU/mL were more prevalent in the HT + multifocal PTC group than in the other groups (84.48% vs 0.43% and 39.25%; P PTC group had higher percentages of patients with elevated thyroid-stimulating hormone and positive central lymph node (LN) metastasis (elevated thyroid-stimulating hormone: 8.7% vs 3.2% and 6.5%, P = .008; positive central LN metastasis: 74.57% vs 67.38% and 0%, P 1300 IU/mL) are definitive indicators of multifocal PTC in HT patients, which may support surgical treatment with total thyroidectomy. © American Academy of Otolaryngology—Head and Neck Surgery Foundation 2015.

  13. Heat Pump Water Heaters and American Homes: A Good Fit?

    Energy Technology Data Exchange (ETDEWEB)

    Franco, Victor; Lekov, Alex; Meyers, Steve; Letschert, Virginie

    2010-05-14

    Heat pump water heaters (HPWHs) are over twice as energy-efficient as conventional electric resistance water heaters, with the potential to save substantial amounts of electricity. Drawing on analysis conducted for the U.S. Department of Energy's recently-concluded rulemaking on amended standards for water heaters, this paper evaluates key issues that will determine how well, and to what extent, this technology will fit in American homes. The key issues include: 1) equipment cost of HPWHs; 2) cooling of the indoor environment by HPWHs; 3) size and air flow requirements of HPWHs; 4) performance of HPWH under different climate conditions and varying hot water use patterns; and 5) operating cost savings under different electricity prices and hot water use. The paper presents the results of a life-cycle cost analysis of the adoption of HPWHs in a representative sample of American homes, as well as national impact analysis for different market share scenarios. Assuming equipment costs that would result from high production volume, the results show that HPWHs can be cost effective in all regions for most single family homes, especially when the water heater is not installed in a conditioned space. HPWHs are not cost effective for most manufactured home and multi-family installations, due to lower average hot water use and the water heater in the majority of cases being installed in conditioned space, where cooling of the indoor environment and size and air flow requirements of HPWHs increase installation costs.

  14. Structural Benchmark Testing for Stirling Convertor Heater Heads

    Science.gov (United States)

    Krause, David L.; Kalluri, Sreeramesh; Bowman, Randy R.

    2007-01-01

    The National Aeronautics and Space Administration (NASA) has identified high efficiency Stirling technology for potential use on long duration Space Science missions such as Mars rovers, deep space missions, and lunar applications. For the long life times required, a structurally significant design limit for the Stirling convertor heater head is creep deformation induced even under relatively low stress levels at high material temperatures. Conventional investigations of creep behavior adequately rely on experimental results from uniaxial creep specimens, and much creep data is available for the proposed Inconel-718 (IN-718) and MarM-247 nickel-based superalloy materials of construction. However, very little experimental creep information is available that directly applies to the atypical thin walls, the specific microstructures, and the low stress levels. In addition, the geometry and loading conditions apply multiaxial stress states on the heater head components, far from the conditions of uniaxial testing. For these reasons, experimental benchmark testing is underway to aid in accurately assessing the durability of Stirling heater heads. The investigation supplements uniaxial creep testing with pneumatic testing of heater head test articles at elevated temperatures and with stress levels ranging from one to seven times design stresses. This paper presents experimental methods, results, post-test microstructural analyses, and conclusions for both accelerated and non-accelerated tests. The Stirling projects use the results to calibrate deterministic and probabilistic analytical creep models of the heater heads to predict their life times.

  15. Optimal Heater Control with Technology of Fault Tolerance for Compensating Thermoforming Preheating System

    Directory of Open Access Journals (Sweden)

    Zhen-Zhe Li

    2015-01-01

    Full Text Available The adjustment of heater power is very important because the distribution of thickness strongly depends on the distribution of sheet temperature. In this paper, the steady state optimum distribution of heater power is searched by numerical optimization in order to get uniform sheet temperature. In the following step, optimal heater power distribution with a damaged heater was found out using the technology of fault tolerance, which will be used to reduce the repairing time when some heaters are damaged. The merit of this work is that the design variable was the power of each heater which can be directly used in the preheating process of thermoforming.

  16. BRAF V600E mutation in prognostication of papillary thyroid cancer (PTC) recurrence.

    Science.gov (United States)

    Czarniecka, Agnieszka; Oczko-Wojciechowska, Małgorzata; Barczyński, Marcin

    2016-10-01

    Papillary thyroid cancer (PTC) offers excellent prognosis, however relapse risk or persistent disease is related to ~30%. Currently, attention is paid to the possibility of patient group selection of different risk of unfavorable outcome to match a particular therapeutic approach. Therefore, interest in new prognostic and predictive markers known preoperatively is observed. BRAF V600E mutation is such a marker. Many studies analyzing the prevalence of the mutation and its relationship with other clinico-pathological risk factors were reported but with controversial conclusions. The prognostic significance of BRAF mutation was confirmed by some single centre studies, a few meta-analyses and a large multicenter retrospective international study. They confirmed a correlation between the mutation and the risk of recurrence. The strongest argument against using BRAF mutation as an independent prognostic and predictive factor in PTC is its high prevalence (30-80%). At present it seems that BRAF mutation is one of the factors influencing the prognosis and it should be analyzed in correlation with other prognostic factors. The most recent ATA recommendations do not indicate a routine application of BRAF status for initial risk stratification in differentiated thyroid cancer due to a lack of evident confirmation of a direct influence of mutation on the increase in relapse risk. However, ATA demonstrates the continuous risk scale for the relapse risk assessment, considering BRAF and/or TERT status. At present, researchers are working on determining the role of BRAF mutation in patients from a low-risk group and its correlations with others molecular events. Currently, BRAF mutation cannot be used as a single, independent predictive factor. However, its usefulness in the context of other molecular and clinico-pathological risk factors cannot be excluded. They may be used to make modern prognostic scales of relapse risk and be applied to individualized diagnostic and

  17. Generation of ionospheric ducts by the HAARP HF heater

    Energy Technology Data Exchange (ETDEWEB)

    Cohen, J A; Pradipta, R; Burton, L M; Labno, A; Lee, M C [Massachusetts Institute of Technology, Cambridge, MA 02139 (United States); Watkins, B J; Fallen, C [University of Alaska Fairbanks, Fairbanks, AK 99775 (United States); Kuo, S P [New York University, Brooklyn, NY 11201 (United States); Burke, W J [Air Force Research Laboratory, Hanscom AFB, MA 01731 (United States); Mabius, D; See, B Z, E-mail: mclee@mit.edu [Boston University, Boston, MA 02215 (United States)

    2010-12-15

    We report an investigation of ionospheric ducts having the shape of large plasma sheets, generated by vertically transmitted HAARP HF heater waves in several experiments conducted in Gakona, Alaska. Theory predicts that O-mode heater wave-created ionospheric ducts form parallel-plate waveguides within the meridional plane, and those generated by the X-mode heater waves are orthogonal to the meridional plane. Our theoretical prediction is supported by measurements of ionosonde data (namely ionograms), range-time-intensity (RTI) plots of UHF and HF backscatter radars, as well as magnetometer data analyses. When these plasma sheets experienced ExB drifts, they were intercepted by the HAARP UHF radar and seen as slanted stripes in the RTI plots. This striking feature was also observed in our earlier experiments using the Arecibo UHF radar.

  18. Development of a cost effective microscope heater stage

    Science.gov (United States)

    Dugre, Joshua; Prayaga, Chandra; Wade, Aaron

    Utilizing 3D printing technology, a heater stage has been developed and implemented for microscopic systems. Due to the flexibility of 3D printing,the heater stage can be easily modified to fit any sample size with only slight modifications to the heating element being required. The sample in contact with the heating element can also easily be secured in a thermal insulator, such as aluminum foil. The thermal gradient of the heater stage has been recorded to be less than 1°C and has been compared to more expensive designs, and the cost effectiveness of the system has been determined. The system has been tested with a sample of the liquid crystal 8CB in order to determine the exact temperatures of the phase transitions of the crystal to verify that the system is applicable to a wide range of experimental physics. UWF Quality Enhancement Plan Award.

  19. Our Environment in Hot Water: Comparing Water Heaters, A Life Cycle Approach Comparing Tank and Tankless Water Heaters in California

    Energy Technology Data Exchange (ETDEWEB)

    Lu, Alison; McMahon, James; Masanet, Eric; Lutz, Jim

    2008-08-13

    Residential water heating is a large source of energy use in California homes. This project took a life cycle approach to comparing tank and tankless water heaters in Northern and Southern California. Information about the life cycle phases was calculated using the European Union's Methodology study for EcoDesign of Energy-using Products (MEEUP) and the National Renewable Energy Laboratory's Life Cycle Inventory (NREL LCI) database. In a unit-to-unit comparison, it was found that tankless water heaters would lessen impacts of water heating by reducing annual energy use by 2800 MJ/year (16% compared to tank), and reducing global warming emissions by 175 kg CO2 eqv./year (18% reduction). Overall, the production and combustion of natural gas in the use phase had the largest impact. Total waste, VOCs, PAHs, particulate matter, and heavy-metals-to-air categories were also affected relatively strongly by manufacturing processes. It was estimated that tankless water heater users would have to use 10 more gallons of hot water a day (an increased usage of approximately 20%) to have the same impact as tank water heaters. The project results suggest that if a higher percentage of Californians used tankless water heaters, environmental impacts caused by water heating would be smaller.

  20. Flat plate solar air heater with latent heat storage

    Science.gov (United States)

    Touati, B.; Kerroumi, N.; Virgone, J.

    2017-02-01

    Our work contains two parts, first is an experimental study of the solar air heater with a simple flow and forced convection, we can use thatlaste oneit in many engineering's sectors as solardrying, space heating in particular. The second part is a numerical study with ansys fluent 15 of the storage of part of this solar thermal energy produced,using latent heat by using phase change materials (PCM). In the experimental parts, we realize and tested our solar air heater in URER.MS ADRAR, locate in southwest Algeria. Where we measured the solarradiation, ambient temperature, air flow, thetemperature of the absorber, glasses and the outlet temperature of the solar air heater from the Sunrise to the sunset. In the second part, we added a PCM at outlet part of the solar air heater. This PCM store a part of the energy produced in the day to be used in peak period at evening by using the latent heat where the PCMs present a grateful storagesystem.A numerical study of the fusion or also named the charging of the PCM using ANSYS Fluent 15, this code use the method of enthalpies to solve the fusion and solidification formulations. Furthermore, to improve the conjugate heat transfer between the heat transfer fluid (Air heated in solar plate air heater) and the PCM, we simulate the effect of adding fins to our geometry. Also, four user define are write in C code to describe the thermophysicalpropriety of the PCM, and the inlet temperature of our geometry which is the temperature at the outflow of the solar heater.

  1. Performance Characteristics of a Modularized and Integrated PTC Heating System for an Electric Vehicle

    Directory of Open Access Journals (Sweden)

    Yoon Hyuk Shin

    2015-12-01

    Full Text Available A modularized positive temperature coefficient heating system has controller-integrated heater modules. Such a heating system that uses a high-voltage power of 330 V was developed in the present study for use in electric vehicles. Four heater modules and one controller with an input power of 5.6 kW were integrated in the modularized system, which was designed for improved heating power density and light weight compared to the conventional heating system, in which the controller is separated. We experimentally investigated the performance characteristics, namely, the heating capacity, energy efficiency, and pressure drop, of a prototype of the developed heating system and found it to have satisfactory performance. The findings of this study will contribute to the development of heating systems for electric vehicles.

  2. A constitutive active MAPK/ERK pathway due to BRAFV600E positively regulates AHR pathway in PTC.

    Science.gov (United States)

    Occhi, Gianluca; Barollo, Susi; Regazzo, Daniela; Bertazza, Loris; Galuppini, Francesca; Guzzardo, Vincenza; Jaffrain-Rea, Marie Lise; Vianello, Federica; Ciato, Denis; Ceccato, Filippo; Watutantrige-Fernando, Sara; Bisognin, Andrea; Bortoluzzi, Stefania; Pennelli, Gianmaria; Boscaro, Marco; Scaroni, Carla; Mian, Caterina

    2015-10-13

    The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor mediating the toxicity and tumor-promoting properties of dioxin. AHR has been reported to be overexpressed and constitutively active in a variety of solid tumors, but few data are currently available concerning its role in thyroid cancer. In this study we quantitatively explored a series of 51 paired-normal and papillary thyroid carcinoma (PTC) tissues for AHR-related genes. We identified an increased AHR expression/activity in PTC, independently from its nuclear dimerization partner and repressor but strictly related to a constitutive active MAPK/ERK pathway. The AHR up-regulation followed by an increased expression of AHR target genes was confirmed by a meta-analysis of published microarray data, suggesting a ligand-independent active AHR pathway in PTC. In-vitro studies using a PTC-derived cell line (BCPAP) and HEK293 cells showed that BRAFV600E may directly modulate AHR localization, induce AHR expression and activity in an exogenous ligand-independent manner. The AHR pathway might represent a potential novel therapeutic target for PTC in the clinical practice.

  3. A constitutive active MAPK/ERK pathway due to BRAFV600E positively regulates AHR pathway in PTC

    Science.gov (United States)

    Regazzo, Daniela; Bertazza, Loris; Galuppini, Francesca; Guzzardo, Vincenza; Jaffrain-Rea, Marie Lise; Vianello, Federica; Ciato, Denis; Ceccato, Filippo; Watutantrige-Fernando, Sara; Bisognin, Andrea; Bortoluzzi, Stefania; Pennelli, Gianmaria; Boscaro, Marco; Scaroni, Carla; Mian, Caterina

    2015-01-01

    The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor mediating the toxicity and tumor-promoting properties of dioxin. AHR has been reported to be overexpressed and constitutively active in a variety of solid tumors, but few data are currently available concerning its role in thyroid cancer. In this study we quantitatively explored a series of 51 paired-normal and papillary thyroid carcinoma (PTC) tissues for AHR-related genes. We identified an increased AHR expression/activity in PTC, independently from its nuclear dimerization partner and repressor but strictly related to a constitutive active MAPK/ERK pathway. The AHR up-regulation followed by an increased expression of AHR target genes was confirmed by a meta-analysis of published microarray data, suggesting a ligand-independent active AHR pathway in PTC. In-vitro studies using a PTC-derived cell line (BCPAP) and HEK293 cells showed that BRAFV600E may directly modulate AHR localization, induce AHR expression and activity in an exogenous ligand-independent manner. The AHR pathway might represent a potential novel therapeutic target for PTC in the clinical practice. PMID:26392334

  4. DNA sequence analysis of the composite plasmid pTC conferring virulence and antimicrobial resistance for porcine enterotoxigenic Escherichia coli.

    Science.gov (United States)

    Fekete, Péter Z; Brzuszkiewicz, Elzbieta; Blum-Oehler, Gabriele; Olasz, Ferenc; Szabó, Mónika; Gottschalk, Gerhard; Hacker, Jörg; Nagy, Béla

    2012-01-01

    In this study the plasmid pTC, a 90 kb self-conjugative virulence plasmid of the porcine enterotoxigenic Escherichia coli (ETEC) strain EC2173 encoding the STa and STb heat-stable enterotoxins and tetracycline resistance, has been sequenced in two steps. As a result we identified five main distinct regions of pTC: (i) the maintenance region responsible for the extreme stability of the plasmid, (ii) the TSL (toxin-specific locus comprising the estA and estB genes) which is unique and characteristic for pTC, (iii) a Tn10 transposon, encoding tetracycline resistance, (iv) the tra (plasmid transfer) region, and (v) the colE1-like origin of replication. It is concluded that pTC is a self-transmissible composite plasmid harbouring antibiotic resistance and virulence genes. pTC belongs to a group of large conjugative E. coli plasmids represented by NR1 with a widespread tra backbone which might have evolved from a common ancestor. This is the first report of a completely sequenced animal ETEC virulence plasmid containing an antimicrobial resistance locus, thereby representing a selection advantage for spread of pathogenicity in the presence of antimicrobials leading to increased disease potential. Copyright © 2011. Published by Elsevier GmbH.

  5. Process for thermal imaging scanning of a swaged heater for an anode subassembly of a hollow cathode assembly

    Science.gov (United States)

    Patterson, Michael J. (Inventor); Verhey, Timothy R. R. (Inventor); Soulas, George C. (Inventor)

    2004-01-01

    A process for thermal imaging scanning of a swaged heater of an anode subassembly of a hollow cathode assembly, comprising scanning a swaged heater with a thermal imaging radiometer to measure a temperature distribution of the heater; raising the current in a power supply to increase the temperature of the swaged heater; and measuring the swaged heater temperature using the radiometer, whereupon the temperature distribution along the length of the heater shall be less than plus or minus 5 degrees C.

  6. Performance of Thermosyphon Solar Water Heaters in Series

    Directory of Open Access Journals (Sweden)

    Tsong-Sheng Lee

    2012-08-01

    Full Text Available More than a single thermosyphon solar water heater may be employed in applications when considerable hot water consumption is required. In this experimental investigation, eight typical Taiwanese solar water heaters were connected in series. Degree of temperature stratification and thermosyphon flow rate in a horizontal tank were evaluated. The system was tested under no-load, intermittent and continuous load conditions. Results showed that there was stratification in tanks under the no-load condition. Temperature stratification also redeveloped after the draw-off. Analysis of thermal performance of the system was conducted for each condition.

  7. Lightweight Radioisotope Heater Unit (LWRHU) production for the Cassini mission

    Energy Technology Data Exchange (ETDEWEB)

    Rinehart, G.H.

    1996-06-01

    The Lightweight Radioisotope Heater Unit (LWRHU) is a {sup 238}PuO{sub 2} fueled heat source designed to provide a thermal watt of power for space missions. The LWRHU will be used to maintain the temperature of various components on the spacecraft at the required level. The heat source consists of a {sup 238}PuO{sub 2} fuel pellet, a Pt-30Rh capsule, a pyrolytic graphite insulator, and a woven graphite aeroshell assembly. Los Alamos has fabricated 180 heater units, which will be used on the Cassini mission. This report summarizes the specifications, fabrication processes, and production data for the heat sources fabricated at Los Alamos.

  8. Development of heat pipes for solar water heaters

    Energy Technology Data Exchange (ETDEWEB)

    Akyurt, M.

    1984-01-01

    Numerous heat pipes were designed, manufactured, and filled on a specially developed filling rig. Each heat pipe was incorporated into a prototype solar water heater developed for this purpose, and was tested under actual insolation conditions. An extensive testing program lasting for more than a year revealed that the heat pipes perform satisfactorily as heat transfer elements in solar water heaters. A special heat pipe featuring a compact and effective condenser configuration was also tested. It was observed to likewise exhibit isothermal behavior and hence promised potential for large scale solar applications.

  9. Heater-Integrated Cantilevers for Nano-Samples Thermogravimetric Analysis

    Directory of Open Access Journals (Sweden)

    Valeria Toffoli

    2013-12-01

    Full Text Available The design and characteristics of a micro-system for thermogravimetric analysis (TGA in which heater, temperature sensor and mass sensor are integrated into a single device are presented. The system consists of a suspended cantilever that incorporates a microfabricated resistor, used as both heater and thermometer. A three-dimensional finite element analysis was used to define the structure parameters. TGA sensors were fabricated by standard microlithographic techniques and tested using milli-Q water and polyurethane microcapsule. The results demonstrated that our approach provides a faster and more sensitive TGA with respect to commercial systems.

  10. Advanced Stirling Convertor Heater Head Durability and Reliability Quantification

    Science.gov (United States)

    Krause, David L.; Shah, Ashwin R.; Korovaichuk, Igor; Kalluri, Sreeramesh

    2008-01-01

    The National Aeronautics and Space Administration (NASA) has identified the high efficiency Advanced Stirling Radioisotope Generator (ASRG) as a candidate power source for long duration Science missions, such as lunar applications, Mars rovers, and deep space missions, that require reliable design lifetimes of up to 17 years. Resistance to creep deformation of the MarM-247 heater head (HH), a structurally critical component of the ASRG Advanced Stirling Convertor (ASC), under high temperatures (up to 850 C) is a key design driver for durability. Inherent uncertainties in the creep behavior of the thin-walled HH and the variations in the wall thickness, control temperature, and working gas pressure need to be accounted for in the life and reliability prediction. Due to the availability of very limited test data, assuring life and reliability of the HH is a challenging task. The NASA Glenn Research Center (GRC) has adopted an integrated approach combining available uniaxial MarM-247 material behavior testing, HH benchmark testing and advanced analysis in order to demonstrate the integrity, life and reliability of the HH under expected mission conditions. The proposed paper describes analytical aspects of the deterministic and probabilistic approaches and results. The deterministic approach involves development of the creep constitutive model for the MarM-247 (akin to the Oak Ridge National Laboratory master curve model used previously for Inconel 718 (Special Metals Corporation)) and nonlinear finite element analysis to predict the mean life. The probabilistic approach includes evaluation of the effect of design variable uncertainties in material creep behavior, geometry and operating conditions on life and reliability for the expected life. The sensitivity of the uncertainties in the design variables on the HH reliability is also quantified, and guidelines to improve reliability are discussed.

  11. Thermal injuries caused by ignition of volatile substances by gas water heaters.

    Science.gov (United States)

    Rutan, R L; Desai, M H; Herndon, D N

    1993-01-01

    Based on the cumulative data of this tertiary care facility over the past 25 years, one out of every 70 pediatric patients admitted to our institution sustained their injuries during an explosive event instigated by the ignition of volatile substances from gas water heaters. The majority of injuries related to gas water heaters can be prevented by decreasing the temperature setpoint of the heater, by protecting the heater element itself, and by elevating the water heater to 18 inches above the floor. The first two issues have been adequately addressed; however, gas-fueled water heaters continue to be installed at floor level. Current national guidelines are too rigid and do not adequately address water-heater installation in private residences. Although general prevention campaigns target appropriate storage of volatile substances, they rarely address the explosive potential of gas water heaters in combination with combustible fumes.

  12. Methanol electro-oxidation on Pt/C modified by polyaniline nanofibers for DMFC applications

    Energy Technology Data Exchange (ETDEWEB)

    Zhiani, Mohammad; Rezaei, Behzad; Jalili, Jalal [Department of Chemistry, Isfahan University of Technology, Isfahan 84156-83111 (Iran)

    2010-09-15

    In the present study, in order to achieve an inexpensive tolerable anode catalyst for direct methanol fuel cell applications, a composite of polyaniline nanofibers and Pt/C nano-particles, identified by PANI/Pt/C, was prepared by in-situ electropolymerization of aniline and trifluoromethane sulfonic acid on glassy carbon. The effect of synthesized PANI nanofibers in methanol electrooxidation reaction was compared by bare Pt/C by different electrochemical methods such as; cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS) and chronoamperometry. Scanning electron microscopy (SEM) was also employed to morphological study of the modified catalyst layer. The test results reveal that introduction of PANI nanofibers within catalyst layer improves the catalyst activity in methanol oxidation, hinders and prevents catalyst from more poisoning by intermediate products of methanol oxidation and improves the mechanical properties of the catalyst layer. SEM images also indicate that PANI nanofibers placed between platinum particles and anchor platinum particles and alleviate the Pt migration during methanol electrooxidation. (author)

  13. Increase of a group of PTC(+) transcripts by curcumin through inhibition of the NMD pathway.

    Science.gov (United States)

    Feng, Dairong; Su, Ruey-Chyi; Zou, Liping; Triggs-Raine, Barbara; Huang, Shangzhi; Xie, Jiuyong

    2015-08-01

    Nonsense-mediated mRNA decay (NMD), an mRNA surveillance mechanism, eliminates premature termination codon-containing (PTC⁺) transcripts. For instance, it maintains the homeostasis of splicing factors and degrades aberrant transcripts of human genetic disease genes. Here we examine the inhibitory effect on the NMD pathway and consequent increase of PTC+ transcripts by the dietary compound curcumin. We have found that several PTC⁺ transcripts including that of serine/arginine-rich splicing factor 1 (SRSF1) were specifically increased in cells by curcumin. We also observed a similar curcumin effect on the PTC⁺ mutant transcript from a Tay-Sachs-causing HEXA allele or from a beta-globin reporter gene. The curcumin effect was accompanied by significantly reduced expression of the NMD factors UPF1, 2, 3A and 3B. Consistently, in chromatin immunoprecipitation assays, curcumin specifically reduced the occupancy of acetyl-histone H3 and RNA polymerase II at the promoter region (-376 to -247nt) of human UPF1, in a time- and dosage-dependent way. Importantly, knocking down UPF1 abolished or substantially reduced the difference of PTC(+) transcript levels between control and curcumin-treated cells. The disrupted curcumin effect was efficiently rescued by expression of exogenous Myc-UPF1 in the knockdown cells. Together, our data demonstrate that a group of PTC⁺ transcripts are stabilized by a dietary compound curcumin through the inhibition of UPF factor expression and the NMD pathway.

  14. Taste Quality Confusions: Influences of Age, Smoking, PTC Taster Status, and other Subject Characteristics.

    Science.gov (United States)

    Doty, Richard L; Chen, Jonathan H; Overend, Jane

    2017-01-01

    Many persons misidentify the quality of taste stimuli, a phenomenon termed "taste confusion." In this study of 1000 persons, we examined the influences of age, sex, causes of chemosensory disturbances, and genetically determined phenylthiocarbamide (PTC) taster status on taste quality confusions for four tastants (sucrose, citric acid, sodium chloride, caffeine). Overall, sour-bitter confusions were most common (19.3%), followed by bitter-sour (11.4%), salty-bitter (7.3%), salty-sour (7.0%), bitter-salty (3.5%), bitter-sweet (3.4), and sour-salty (2.4%) confusions. Confusions for sweet were PTC tasters had fewer confusions than non-tasters except for salty-bitter confusions. Confusions typically increased monotonically with age. Current smokers exhibited more sour-bitter confusions than never smokers (48.9% vs. 32.2%), whereas past smokers had more bitter-sour confusions than never smokers (23.8% vs. 14.2%). Previous head trauma was associated with higher bitter-salty and salty-bitter confusions relative to those of some other etiologies. This study demonstrates, for the first time, that multiple subject factors influence taste confusions and, along with literature accounts, supports the view that there are both biological and psychological determinants of taste quality confusions.

  15. The New Heat Treatment Technology of A356 Aluminium Alloy Prepared by Ptc

    Science.gov (United States)

    Zhang, Lianyong; Jiang, Yanhua; Ma, Zhuang; Wang, Wenkui

    Phase Transition Cooling (PTC), using the absorbed latent heat during the melting of phase transition cooling medium to cool and solidify alloys in the process of casting, is a new casting technology. Specimens of A356 casting aluminum alloy were prepared by this method in the paper. The new heat treatment process (cast and then aging directly without solid solution) of A356 alloy was performed. For comparison, the conventional T6 heat treatment (solution and then aging treatment) was performed too. The mechanical properties of A356 alloy with different heat treatments were measured by tensile strength testing methods and microstructures of the alloy with different heat treatment process were investigated by optical microscopy (OM), scanning electron microscopy (SEM), differential scanning calorimetry (DSC), X-rays diffraction (XRD) and transmission electron microscopy (TEM) too. The results show that ultimate tensile strength (UTS) of A356 alloy with the new heat treatment process is much higher than that with conventional heat treatment while the elongations with the two heat treatment processes are very close. This is due to the grain refinement obtained after PTC processing.

  16. High-Temperature Compatible Nickel Silicide Thermometer And Heater For Catalytic Chemical Microreactors

    DEFF Research Database (Denmark)

    Jensen, Søren; Quaade, U.J.; Hansen, Ole

    2005-01-01

    Integration of heaters and thermometers is important for agile and accurate control and measurement of the thermal reaction conditions in microfabricated chemical reactors (microreactors). This paper describes development and operation of nickel silicide heaters and temperature sensors...... for temperatures exceeding 700 °C. The heaters and thermometers are integrated with chemical microreactors for heterogeneous catalytic conversion of gasses, and thermally activated catalytic conversion of CO to CO2 in the reactors is demonstrated. The heaters and thermometers are shown to be compatible...

  17. The Kto-Skd complex can regulate ptc expression by interacting with Cubitus interruptus (Ci) in the Hedgehog signaling pathway.

    Science.gov (United States)

    Mao, Feifei; Yang, Xiaofeng; Fu, Lin; Lv, Xiangdong; Zhang, Zhao; Wu, Wenqing; Yang, Siqi; Zhou, Zhaocai; Zhang, Lei; Zhao, Yun

    2014-08-08

    The hedgehog (Hh) signaling pathway plays a very important role in metazoan development by controlling pattern formation. Drosophila imaginal discs are subdivided into anterior and posterior compartments that derive from adjacent cell populations. The anterior/posterior (A/P) boundaries, which are critical to maintaining the position of organizers, are established by a complex mechanism involving Hh signaling. Here, we uncover the regulation of ptc in the Hh signaling pathway by two subunits of mediator complex, Kto and Skd, which can also regulate boundary location. Collectively, we provide further evidence that Kto-Skd affects the A/P-axial development of the whole wing disc. Kto can interact with Cubitus interruptus (Ci), bind to the Ci-binding region on ptc promoter, which are both regulated by Hh signals to down-regulate ptc expression. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

  18. Inflammatory mediators, tumor necrosis factor-α and interferon-γ, induce EMT in human PTC cell lines.

    Science.gov (United States)

    Lv, Nannan; Gao, Yun; Guan, Haixia; Wu, Dan; Ding, Shuangning; Teng, Weiping; Shan, Zhongyan

    2015-10-01

    Inflammatory mediators, tumor necrosis factor (TNF)-α and interferon (IFN)-γ, promote adverse outcomes in numerous types of cancer; however, their role in papillary thyroid cancer (PTC) remains unclear. The aim of the present study was to investigate the influence of TNF-α and IFN-γ on the migration, invasion and epithelial-mesenchymal transition (EMT) of the three PTC cell lines, TPC-1, BCPAP and K1. The effect of TNF-α and IFN-γ on cell migration and invasion was assessed by wound-healing and Transwell assays. In addition, the mRNA and protein expression levels of the EMT makers, E-cadherin, N-cadherin and vimentin, were analyzed using reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and immunoblot analysis. The wound-healing and Transwell experiments revealed that TNF-α and IFN-γ increased the migratory and invasive behavior of PTC cells (PPTC cells.

  19. Comparative performance of coriander dryer coupled to solar air heater and solar air-heater-cum-rockbed storage

    Energy Technology Data Exchange (ETDEWEB)

    Chauhan, P.M.; Choudhury, C.; Garg, H.P. [Indian Inst. of Technology, Centre for Energy Studies, New Delhi (India)

    1996-03-01

    In the present communication, efforts have been made to study the drying characteristics of coriander in a stationary 0.5 tonne/batch capacity deep-bed dryer coupled to a solar air heater and a rockbed storage unit to receive hot air during sunshine and off-sunshine hours, respectively. The drying bed was assumed to consist of a number of thin layers of grains stacked upon each other. The theoretical investigation was made by writing the energy and mass balance equations for different components of the dryer-cum-air-heater-cum-storage and by adopting a finite difference approach for simulation. (author)

  20. 77 FR 74559 - Energy Conservation Program for Consumer Products: Test Procedures for Residential Water Heaters...

    Science.gov (United States)

    2012-12-17

    ... descriptors (i.e., thermal efficiency and pool heater heating seasonal efficiency), as well as seasonal energy... thermal efficiency metric for pool heaters, but did not propose an integrated annual fuel utilization... states that for pool heaters, the descriptor shall be thermal efficiency. (42 U.S.C....

  1. 30 CFR 75.341 - Direct-fired intake air heaters.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Direct-fired intake air heaters. 75.341 Section... air heaters. (a) If any system used to heat intake air malfunctions, the heaters affected shall switch off automatically. (b) Thermal overload devices shall protect the blower motor from overheating....

  2. 46 CFR 61.30-5 - Preparation of thermal fluid heater for inspection and test.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 2 2010-10-01 2010-10-01 false Preparation of thermal fluid heater for inspection and... ENGINEERING PERIODIC TESTS AND INSPECTIONS Tests and Inspections of Fired Thermal Fluid Heaters § 61.30-5 Preparation of thermal fluid heater for inspection and test. For visual inspection, access plates and...

  3. 76 FR 63211 - Energy Efficiency Program: Test Procedures for Residential Water Heaters, Direct Heating...

    Science.gov (United States)

    2011-10-12

    ... descriptors (i.e., thermal efficiency and pool heater heating seasonal efficiency), as well as seasonal energy... ``efficiency descriptor,'' EPCA specifies that for pool heaters, the efficiency descriptor shall be ``thermal efficiency.'' (42 U.S.C. 6291(22)(E)) Further, EPCA defines the ``thermal efficiency of pool heaters'' as...

  4. Recovery Act: Water Heater ZigBee Open Standard Wireless Controller

    Energy Technology Data Exchange (ETDEWEB)

    Butler, William P. [Emerson Electric Co., St. Louis, MO (United States); Buescher, Tom [Emerson Electric Co., St. Louis, MO (United States)

    2014-04-30

    The objective of Emerson's Water Heater ZigBee Open Standard Wireless Controller is to support the DOE's AARA priority for Clean, Secure Energy by designing a water heater control that levels out residential and small business peak electricity demand through thermal energy storage in the water heater tank.

  5. TOTAL PARTICLE, SULFATE, AND ACIDIC AEROSOL EMISSIONS FROM KEROSENE SPACE HEATERS

    Science.gov (United States)

    Chamber studies were conducted on four unvented kerosene space heaters to assess emissions of total particle, sulfate, and acidic aerosol. The heaters tested represented four burner designs currently in use by the public. Kerosene space heaters are a potential source of fine part...

  6. Mountain Plains Learning Experience Guide: Appliance Repair. Course: Heater-Type Appliances.

    Science.gov (United States)

    Ziller, T.

    One of two individualized courses included in an appliance repair curriculum (see CE 027 767), this course covers minor and major heater-type appliances. The course is comprised of six units: (1) Irons, (2) Roasters, (3) Space Heaters, (4) Water Heaters, (5) Electric Ranges, and (6) Gas Ranges. Each unit begins with a Unit Learning Experience…

  7. 40 CFR 63.7506 - Do any boilers or process heaters have limited requirements?

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 13 2010-07-01 2010-07-01 false Do any boilers or process heaters have limited requirements? 63.7506 Section 63.7506 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... or process heaters have limited requirements? (a) New or reconstructed boilers and process heaters...

  8. Role of perfluorosulfonic ionomer as protective agent against strong adsorption of (bi)sulfate anions. Relevance in the determination of the area of Pt/C electrocatalysts

    Energy Technology Data Exchange (ETDEWEB)

    Garcia-Rodriguez, S.; Rojas, S.; Pena, M.A.; Fierro, J.L.G. [Grupo de Quimica y Energia Sostenibles, Instituto de Catalisis y Petroleoquimica, CSIC C/Marie Curie 2, 28049 Madrid (Spain); Vellosillo, M.; Ocon, P. [Departamento de Quimica-Fisica, Facultad de Ciencias, Universidad Autonoma de Madrid, Campus de Cantoblanco, 28049 Madrid (Spain)

    2010-10-15

    This work aims to shed light on the wide dispersion of the values of the area of Pt/C electrodes reported when evaluated by means of the thin-film electrode approach. The effect of the Perfluorosulfonic Ionomer (PFSI) content of the electrodes and the nature of the electrolyte are discussed. The results disclose that the area of the Pt electrodes evaluated by electrochemical techniques is related to the actual PFSI content on the electrode and to the nature of the electrolyte. Using HClO{sub 4} as electrolyte, electrode area values are independent of the PFSI content. On the contrary, if experiments are recorded in H{sub 2}SO{sub 4}, the electrode area value increases with the increasing PFSI content, irrespectively of the Pt loading. Such effect is ascribed to the interaction of the sulfonic groups from the PFSI with the surface of the Pt nanoparticles, avoiding the strong adsorption of the bisulfate anions. (author)

  9. Targeting of BMI-1 with PTC-209 shows potent anti-myeloma activity and impairs the tumour microenvironment.

    Science.gov (United States)

    Bolomsky, Arnold; Schlangen, Karin; Schreiner, Wolfgang; Zojer, Niklas; Ludwig, Heinz

    2016-03-02

    The polycomb complex protein BMI-1 (BMI-1) is a putative oncogene reported to be overexpressed in multiple myeloma (MM). Silencing of BMI-1 was shown to impair the growth and survival of MM cells. However, therapeutic agents specifically targeting BMI-1 were not available so far. Here, we investigated PTC-209, a novel small molecule inhibitor of BMI-1, for its activity in MM. BMI-1 expression was analysed in human MM cell lines and primary MM cells by using publically available gene expression profiling (GEP) data. The anti-MM activity of PTC-209 was investigated by viability testing, cell cycle analysis, annexin V and 7-AAD staining, quantification of cleaved poly(ADP-ribose) polymerase (PARP), JC-1 as well as colony formation assays. Deregulation of central myeloma growth and survival genes was studied by quantitative PCR and flow cytometry, respectively. In addition, the impact of PTC-209 on in vitro osteoclast, osteoblast and tube formation was analysed. We confirmed overexpression of BMI-1 in MM patients by using publically available GEP datasets. Of note, BMI-1 expression was further increased at relapse which translated into significantly shorter overall survival in relapsed/refractory patients treated with bortezomib or dexamethasone. Treatment with PTC-209 significantly decreased viable cell numbers in human MM cell lines, induced a G1 cell cycle arrest, promoted apoptosis and demonstrated synergistic activity with pomalidomide and carfilzomib. The anti-MM activity of PTC-209 was accompanied by a significant decrease of cyclin D1 (CCND1) and v-myc avian myelocytomatosis viral oncogene homolog (MYC) expression as well as upregulation of cyclin-dependent kinase inhibitor 1A (CDKN1A) and cyclin-dependent kinase inhibitor 1B (CDKN1B). We also observed upregulation of NOXA (up to 3.6 ± 1.2-fold induction, P = 0.009) and subsequent downregulation of myeloid cell leukemia 1 (MCL-1) protein levels, which likely mediates the apoptotic effects of PTC-209

  10. Laboratory Performance Evaluation of Residential Integrated Heat Pump Water Heaters

    Energy Technology Data Exchange (ETDEWEB)

    Sparn, B.; Hudon, K.; Christensen, D.

    2014-06-01

    This paper explores the laboratory performance of five integrated Heat Pump Water Heaters (HPWHs) across a wide range of operating conditions representative of US climate regions. HPWHs are expected to provide significant energy savings in certain climate zones when compared to typical electric resistance water heaters. Results show that this technology is a viable option in most climates, but differences in control schemes and design features impact the performance of the units tested. Tests were conducted to map heat pump performance across the operating range and to determine the logic used to control the heat pump and the backup electric heaters. Other tests performed include two unique draw profile tests, reduced air flow performance tests and the standard DOE rating tests. The results from all these tests are presented here for all five units tested. The results of these tests will be used to improve the EnergyPlus heat pump water heater for use in BEopt(tm) whole-house building simulations.

  11. Laboratory Performance Evaluation of Residential Integrated Heat Pump Water Heaters

    Energy Technology Data Exchange (ETDEWEB)

    Sparn, B.; Hudon, K.; Christensen, D.

    2014-06-01

    This paper explores the laboratory performance of five integrated Heat Pump Water Heaters (HPWHs) across a wide range of operating conditions representative of U.S. climate regions. HPWHs are expected to provide significant energy savings in certain climate zones when compared to typical electric resistance water heaters. Results show that this technology is a viable option in most climates, but differences in control schemes and design features impact the performance of the units tested. Tests were conducted to map heat pump performance across the operating range and to determine the logic used to control the heat pump and the backup electric heaters. Other tests performed include two unique draw profile tests, reduced air flow performance tests and the standard DOE rating tests. The results from all these tests are presented here for all five units tested. The results of these tests will be used to improve the EnergyPlus heat pump water heater for use in BEopt™ whole-house building simulations.

  12. Solar water heaters in China: A new day dawning

    NARCIS (Netherlands)

    Han, Jingyi; Mol, A.P.J.; Lu, Y.

    2010-01-01

    Solar thermal utilization, especially the application of solar water heater technology, has developed rapidly in China in recent decades. Manufacturing and marketing developments have been especially strong in provinces such as Zhejiang, Shandong and Jiangsu. This paper takes Zhejiang, a relatively

  13. Fast thermal nanoimprint lithography by a stamp with integrated heater

    DEFF Research Database (Denmark)

    Tormen, Massimo; Malureanu, Radu; Pedersen, Rasmus Haugstrup

    2008-01-01

    We propose fast nanoimprinting lithography (NIL) process based on the use of stamps with integrated heater. The latter consists of heavily ion implantation n-type doped silicon layer buried below the microstructured surface of the stamp. The stamp is heated by Joule effect, by 50 μs 25 Hz...

  14. Demand Response Performance of GE Hybrid Heat Pump Water Heater

    Energy Technology Data Exchange (ETDEWEB)

    Widder, Sarah H.; Parker, Graham B.; Petersen, Joseph M.; Baechler, Michael C.

    2013-07-01

    This report describes a project to evaluate and document the DR performance of HPWH as compared to ERWH for two primary types of DR events: peak curtailments and balancing reserves. The experiments were conducted with GE second-generation “Brillion”-enabled GeoSpring hybrid water heaters in the PNNL Lab Homes, with one GE GeoSpring water heater operating in “Standard” electric resistance mode to represent the baseline and one GE GeoSpring water heater operating in “Heat Pump” mode to provide the comparison to heat pump-only demand response. It is expected that “Hybrid” DR performance, which would engage both the heat pump and electric elements, could be interpolated from these two experimental extremes. Signals were sent simultaneously to the two water heaters in the side-by-side PNNL Lab Homes under highly controlled, simulated occupancy conditions. This report presents the results of the evaluation, which documents the demand-response capability of the GE GeoSpring HPWH for peak load reduction and regulation services. The sections describe the experimental protocol and test apparatus used to collect data, present the baselining procedure, discuss the results of the simulated DR events for the HPWH and ERWH, and synthesize key conclusions based on the collected data.

  15. Assessment of a Hybrid Retrofit Gas Water Heater

    Energy Technology Data Exchange (ETDEWEB)

    Hoeschele, Marc [Davis Energy Group, Davis, CA (United States); Weitzel, Elizabeth [Davis Energy Group, Davis, CA (United States); Backman, Christine [Davis Energy Group, Davis, CA (United States)

    2017-02-28

    This project completed a modeling evaluation of a hybrid gas water heater that combines a reduced capacity tankless unit with a downsized storage tank. This product would meet a significant market need by providing a higher efficiency gas water heater solution for retrofit applications while maintaining compatibility with the 1/2 inch gas lines and standard B vents found in most homes. The TRNSYS simulation tool was used to model a base case 0.60 EF atmospheric gas storage water, a 0.82 EF non-condensing gas tankless water heater, an existing (high capacity) hybrid unit on the market, and an alternative hybrid unit with lower storage volume and reduced gas input requirements. Simulations were completed under a 'peak day' sizing scenario with 183 gpd hot water loads in a Minnesota winter climate case. Full-year simulations were then completed in three climates (ranging from Phoenix to Minneapolis) for three hot water load scenarios (36, 57, and 96 gpd). Model projections indicate that the alternative hybrid offers an average 4.5% efficiency improvement relative to the 0.60 EF gas storage unit across all scenarios modeled. The alternative hybrid water heater evaluated does show promise, but the current low cost of natural gas across much of the country and the relatively small incremental efficiency improvement poses challenges in initially building a market demand for the product.

  16. 14 CFR 25.859 - Combustion heater fire protection.

    Science.gov (United States)

    2010-01-01

    ... passages. (b) Ventilating air ducts. Each ventilating air duct passing through any fire zone must be..., the ventilating air duct downstream of each heater must be fireproof for a distance great enough to... fluids or vapors into the ventilating airstream. (c) Combustion air ducts. Each combustion air duct...

  17. CHARACTERIZATION OF POPULATION AND USAGE OF UNVENTED KEROSENE SPACE HEATERS

    Science.gov (United States)

    The report gives results of a study of the market penetration of unvented kerosene space heaters (UKSHs) in the residential sector, The study was aimed at gathering baseline information to help assess the magnitude and potential severity of a problem involving emissions from unve...

  18. Assessment of a Hybrid Retrofit Gas Water Heater

    Energy Technology Data Exchange (ETDEWEB)

    Hoeschele, Marc [Alliance for Residential Building Innovation (ARBI), Davis, CA (United States); Weitzel, Elizabeth [Alliance for Residential Building Innovation (ARBI), Davis, CA (United States); Backman, Christine [Alliance for Residential Building Innovation (ARBI), Davis, CA (United States)

    2017-02-01

    This project completed a modeling evaluation of a hybrid gas water heater that combines a reduced capacity tankless unit with a downsized storage tank. This product would meet a significant market need by providing a higher efficiency gas water heater solution for retrofit applications while maintaining compatibility with the 1/2 inch gas lines and standard B vents found in most homes. The TRNSYS simulation tool was used to model a base case 0.60 EF atmospheric gas storage water, a 0.82 EF non-condensing gas tankless water heater, an existing (high capacity) hybrid unit on the market, and an alternative hybrid unit with lower storage volume and reduced gas input requirements. Simulations were completed under a 'peak day' sizing scenario with 183 gpd hot water loads in a Minnesota winter climate case. Full-year simulations were then completed in three climates (ranging from Phoenix to Minneapolis) for three hot water load scenarios (36, 57, and 96 gpd). Model projections indicate that the alternative hybrid offers an average 4.5% efficiency improvement relative to the 0.60 EF gas storage unit across all scenarios modeled. The alternative hybrid water heater evaluated does show promise, but the current low cost of natural gas across much of the country and the relatively small incremental efficiency improvement poses challenges in initially building a market demand for the product.

  19. Thermomechanics of the granular bed T-joint water heater

    Science.gov (United States)

    Teplitskii, Yu. S.; Belonovich, D. G.

    2012-11-01

    On the basis of the heat transfer model taking into account the radiative transport the temperature distribution and the resistance of the water heater with a granular packing having two independent air inlets have been investigated. The generalized dependence for calculating the resistance of the granular bed has been obtained.

  20. an automatic safety control for immersion water heater

    African Journals Online (AJOL)

    NIJOTECH

    heater in the Nigerian market in its current form is depicted ... the comparator used is an open collector type. It is instructive to take a close look at the operation of the Schmitt trigger. The equivalent .... additional advantage of keeping the water.

  1. Electrothermal pumping with interdigitated electrodes and resistive heaters.

    Science.gov (United States)

    Williams, Stuart J; Green, Nicolas G

    2015-08-01

    Interdigitated electrodes are used in electrokinetic lab-on-a-chip devices for dielectrophoretic trapping and characterization of suspended particles, as well as the production of field-induced fluid flow via AC electroosomosis and electrothermal mechanisms. However, the optimum design for dielectrophoresis, that if symmetrical electrodes, cannot induce bulk electrohydrodynamic pumping. In addition, the mechanism of intrinsic electrothermal pumping is affected by the properties of the fluid, with thermal fields being generated by Joule Heating. This work demonstrates the incorporation of an underlying thin film heater, electrically isolated from the interdigitated electrodes by an insulator layer, to enhance bulk electrothermal pumping. The use of integrated heaters allows the thermal field generation to be controlled independently of the electric field. Numerical simulations are performed to demonstrate the importance of geometrical arrangement of the heater with respect to the interdigitated electrodes, as well as electrode size, spacing, and arrangement. The optimization of such a system is a careful balance between electrokinetics, heat transfer, and fluid dynamics. The heater location and electrode spacing influence the rate of electrothermal pumping significantly more than electrode width and insulator layer thickness. This demonstration will aid in the development of microfluidic electrokinetic systems that want to utilize the advantages associated with electrothermal pumping while simultaneously applying other lab-on-a-chip electrokinetics like dielectrophoresis.

  2. Evaluation of the Demand Response Performance of Electric Water Heaters

    Energy Technology Data Exchange (ETDEWEB)

    Mayhorn, Ebony T. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Widder, Sarah H. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Parker, Steven A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Pratt, Richard M. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Chassin, Forrest S. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2015-03-17

    The purpose of this project is to verify or refute many of the concerns raised by utilities regarding the ability of large tank HPWHs to perform DR by measuring the performance of HPWHs compared to ERWHs in providing DR services. perform DR by measuring the performance of HPWHs compared to ERWHs in providing DR services. This project was divided into three phases. Phase 1 consisted of week-long laboratory experiments designed to demonstrate technical feasibility of individual large-tank HPWHs in providing DR services compared to large-tank ERWHs. In Phase 2, the individual behaviors of the water heaters were then extrapolated to a population by first calibrating readily available water heater models developed in GridLAB-D simulation software to experimental results obtained in Phase 1. These models were used to simulate a population of water heaters and generate annual load profiles to assess the impacts on system-level power and residential load curves. Such population modeling allows for the inherent and permanent load reduction accomplished by the more efficient HPWHs to be considered, in addition to the temporal DR services the water heater can provide by switching ON or OFF as needed by utilities. The economic and emissions impacts of using large-tank water heaters in DR programs are then analyzed from the utility and consumer perspective, based on National Impacts Analysis in Phase 3. Phase 1 is discussed in this report. Details on Phases 2 and 3 can be found in the companion report (Cooke et al. 2014).

  3. Genetic characterization of the CcpA-dependent, cellobiose-specific PTS system comprising CelB, PtcB and PtcA that transports lactose in Lactococcus lactis IL1403.

    Science.gov (United States)

    Aleksandrzak-Piekarczyk, Tamara; Polak, Jolanta; Jezierska, Beata; Renault, Pierre; Bardowski, Jacek

    2011-01-31

    Lactose metabolism is one of the most important areas of research on Lactic Acid Bacteria (LAB). In rapidly acidifying industrial Lactococcus lactis strains, lactose is transported by a lactose-specific phosphotransferase system (PTS) encoded by a plasmid. However, an alternative lactose catabolic pathway was evidenced in the plasmid-cured, and thus initially lactose-negative L. lactis IL1403. We showed that in this strain the chromosomally-encoded cellobiose-specific PTS system comprising the celB, ptcB and ptcA genes is also able to transport lactose. By expression studies in the wild type IL1403 strain and IBB550, its ccpA-deficient derivative, we demonstrated that celB, ptcB and ptcA are tightly regulated by the general catabolite repression system, whereas celB additionally requires the presence of cellobiose to be fully induced. The comparison of expression levels of sugar catabolic genes indicated that the efficiency of CcpA-mediated catabolic repression depends on conservation of the cre sequence, and that in the case of perfect matching with the cre consensus, CcpA still drives a strong repression even under non-repressing conditions.

  4. Three-phase heaters with common overburden sections for heating subsurface formations

    Energy Technology Data Exchange (ETDEWEB)

    Vinegar, Harold J [Bellaire, TX

    2012-02-14

    A heating system for a subsurface formation is described. The heating system includes three substantially u-shaped heaters with first end portions of the heaters being electrically coupled to a single, three-phase wye transformer and second end portions of the heaters being electrically coupled to each other and/or to ground. The three heaters may enter the formation through a first common wellbore and exit the formation through a second common wellbore so that the magnetic fields of the three heaters at least partially cancel out in the common wellbores.

  5. Phenylthiocarbamide (PTC) perception in ultra-high risk for psychosis participants who develop schizophrenia: testing the evidence for an endophenotypic marker.

    Science.gov (United States)

    Brewer, Warrick J; Lin, Ashleigh; Moberg, Paul J; Smutzer, Gregory; Nelson, Barnaby; Yung, Alison R; Pantelis, Christos; McGorry, Patrick D; Turetsky, Bruce I; Wood, Stephen J

    2012-08-30

    Reports suggesting that schizophrenia participants are more likely to be phenylthiocarbamide (PTC) non-tasters when compared to controls have recently been controversial. If supported, a genetic-based phenotypic variation in PTC taster status is implicated, suggesting a greater illness risk for those participants with recessive alleles for the TAS2R38 receptor. Should PTC insensitivity be a schizophrenia endophenotype, then it would be expected in follow-up of ultra high-risk for psychosis participants who later develop schizophrenia (UHR-S). UHR-S was hypothesised to show reduced PTC sensitivity compared to those who were previously at risk, but did not transition (UHR-NP). PTC perception was assessed in 219 UHR participants at long-term follow-up, of whom 53 had transitioned to psychosis (UHR-P) during the follow-up period. Fifteen of the 219 participants were diagnosed with schizophrenia. Seventy-eight had a family history of psychotic disorder. No differences in PTC taster status were found in UHR participants based upon transition to psychosis status, schizophrenia diagnosis, or family history of schizophrenia. This report indicates that schizophrenia development among UHR participants is not associated with PTC tasting deficits and fails to support previous findings that inability to detect the bitter taste of PTC is a schizophrenia endophenotype. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

  6. Modifications and Modeling of the Fission Surface Power Primary Test Circuit (FSP-PTC)

    Science.gov (United States)

    Garber, Anne E.

    2008-01-01

    An actively pumped alkali metal flow circuit, designed and fabricated at the NASA Marshall Space Flight Center, underwent a range of tests at MSFC in early 2007. During this period, system transient responses and the performance of the liquid metal pump were evaluated. In May of2007, the circuit was drained and cleaned to prepare for multiple modifications: the addition of larger upper and lower reservoirs, the installation of an annular linear induction pump (ALIP), and the inclusion of a closeable orifice in the test section. Performance of the ALIP, provided by Idaho National Laboratory (INL), will be evaluated when testing resumes. Data from the first round of testing has been used to refine the working system model, developed using the Generalized Fluid System Simulation Program (GFSSP). This paper covers the modifications of the FSP-PTC and the updated GFSSP system model.

  7. Recent Updates to the Fission Surface Power Primary Test Circuit (FSP-PTC)

    Science.gov (United States)

    Garber, Anne E.

    2008-01-01

    An actively pumped alkali metal flow circuit, designed and fabricated at the NASA Marshall Space Flight Center, underwent a range of tests at MSFC in early 2007. During this period, system transient responses and the performance of the liquid metal pump were evaluated. In May of 2007, the circuit was drained and cleaned to prepare for multiple modifications: the addition of larger upper and lower reservoirs, the installation of an annular linear induction pump (ALIP), and the inclusion of a closeable orifice in the test section. Modifications are now complete and testing has resumed. Performance of the ALIP, provided by Idaho National Laboratory (1NL), is the subject of the first round of experimentation. This presentation details the physical changes made to the FSP-PTC and the current test program.

  8. PENGENDALIAN MESIN HOIST HANGER DALAM PROSES PTC/ED MENGGUNAKAN PLC OMRON

    Directory of Open Access Journals (Sweden)

    Wahyudi Wahyudi

    2012-02-01

    Full Text Available The development of technology demands efficient and work speed, so it needs a system which can handleseveral things.This problem can be covered with PLC (Programmable Logic Control that can integrateseveral self standing component to be an integrated control system and can be changed the configurationwithout change all instrument. Modify the ladder program can alter system of PLC. This paper showsHoist Hanger system in PTC/ED (Pre Treatment Chemical/Electrocoat Dispotition process that controlledby PLC. Above input from limit switch, sensor, or the other input, PLC system drives the motorrelay Hoist Hanger machine. That cause the motor relay Hoist Hanger change its condition, so the movingof Hoist Hanger machine will be suitable with PLC program.

  9. PTC/NTC Behavior of PVDF Composites Filled with GF and CF

    Institute of Scientific and Technical Information of China (English)

    WANG Xin-lei; ZHANG Guo; LI Ji-xin; LI Zhuo-shi; LIU Zhan-fang; LIU Xiu-qi

    2008-01-01

    Conductive polyvinylidene fluoride(PVDF) matrix composites filled with graphited fiber(GF) or carbon fiber(CF) were prepared by the melt-mixing method.The breakage and length distribution of the fibers in the polymer matrix were studied by scanning electron microscope(SEM) and optical microscope(OM) observations,respectively.The differences in the positive temperature coefficient(PTC) effects of the composites were mainly attributed to inter-fiber contact ability.The elimination of the negative temperature coefficient(NTC) effect for CF/PVDF composite was because of an increase in the viscosity of the polymer matrix.With the same filler content,CF could be more effective,to eliminate the NTC effect when compared with GF.Addition of 2% CF(mass fraction) in the PVDF composite with 7% GF(mass fraction) could effectively eliminate the NTC phenomenon of the composite.

  10. Nickel-doped ceria nanoparticles for promoting catalytic activity of Pt/C for ethanol electrooxidation

    Science.gov (United States)

    Tan, Qiang; Du, Chunyu; Sun, Yongrong; Du, Lei; Yin, Geping; Gao, Yunzhi

    2014-10-01

    This paper reports the facile synthesis of monodispersed nickel-doped ceria nanoparticles by a thermal decomposition method, which is used to promote catalytic properties of Pt/C. The Pt/Ni-doped CeO2/C catalyst obtained exhibits remarkably high activity and stability towards the ethanol electrooxidation in acidic media. This is attributed to higher oxygen releasing capacity and stronger interaction of Ni-doped CeO2 with Pt than pure CeO2 nanoparticles that contribute positively to the removal of poisoning intermediates. We believe that the design concept and synthetic strategy of metal doped oxides used for fuel cell catalysts can be potentially extended to other catalytic fields.

  11. Modifications and Modeling of the Fission Surface Power Primary Test Circuit (FSP-PTC)

    Science.gov (United States)

    Garber, Anne E.

    2008-01-01

    An actively pumped alkali metal flow circuit, designed and fabricated at the NASA Marshall Space Flight Center, underwent a range of tests at MSFC in early 2007. During this period, system transient responses and the performance of the liquid metal pump were evaluated. In May of2007, the circuit was drained and cleaned to prepare for multiple modifications: the addition of larger upper and lower reservoirs, the installation of an annular linear induction pump (ALIP), and the inclusion of a closeable orifice in the test section. Performance of the ALIP, provided by Idaho National Laboratory (INL), will be evaluated when testing resumes. Data from the first round of testing has been used to refine the working system model, developed using the Generalized Fluid System Simulation Program (GFSSP). This paper covers the modifications of the FSP-PTC and the updated GFSSP system model.

  12. PTC simulations, stochastic optimization and safety strategies for groundwater pumping management: case study of the Hersonissos Coastal Aquifer in Crete

    Science.gov (United States)

    Stratis, P. N.; Dokou, Z. A.; Karatzas, G. P.; Papadopoulou, E. P.; Saridakis, Y. G.

    2016-06-01

    Recently, the well-known Princeton Transport Code (PTC), a groundwater flow and contaminant transport simulator, has been coupled with the ALgorithm of Pattern EXtraction (ALOPEX), a real-time stochastic optimization method, to provide a freshwater pumping management tool for coastal aquifers, aiming in preventing saltwater intrusion. In our previous work (Proceedings of INASE/CSCC-WHH 2015, Recent Advances in Environmental and Earth Sciences and Economics, pp 329-334, 2015), the PTC-ALOPEX approach was used in studying the saltwater contamination problem for the coastal aquifer at Hersonissos, Crete. Extending these results, in the present study the PTC-ALOPEX approach is equipped with a nodal safety strategy that effectively controls saltwater front's advancement inside the aquifer. In cooperation with an appropriate penalty system, the performance of PTC-ALOPEX algorithm is studied considering several pumping and weather condition scenarios. This study also establishes pumping/well scenarios that ensure the needed volume of fresh water to the local community without risking saltwater contamination.

  13. Successful Strategies for Rapidly Upgrading PTC Windchill 9.1 to Windchill 10.1 on a Light Budget

    Science.gov (United States)

    Shearrow, Charles A.

    2013-01-01

    Topics covered include: The Frugal Times Historical Upgrade Process; Planning for Possible Constraints; PTC Compatibility Matrix; In-Place Upgrade Process; Pre-Upgrade Activities; Upgrade Activities; Post Upgrade Activities; Results of the Upgrade; Tips for an Upgrade On a Shoestring Budget.

  14. Prevalence and Genetic Analysis of Bitter Taste Perception for Phenylthiocarbamide (PTC) Among Some Muslim Populations of Uttar Pradesh, India.

    Science.gov (United States)

    Hussain, Ruqaiya; Shah, Ahsana; Afzal, Mohammad

    2014-04-01

    The ability to taste Phenylthiocarbamide (PTC), a bitter organic compound, described as a bimodal autosomal trait is widely used to know the heritable trait in both genetic and anthropological studies. The present study was carried out to analyze the prevalence of PTC taste sensitivity and to determine the gene frequencies among some Muslim populations of Uttar Pradesh, India. This study has some physiological relevance to highlight the adaptability of endogamous groups to behavioral traits in the same place. Unrelated, healthy individuals of both sexes (Male-403, Female-418) belonging to different populations of Uttar Pradesh, India were randomly selected with the age range of 16-45 years observed for phenylthiocarbamide to taste sensitivity. PTC tasting ability was measured by using a serial dilution method of Harris and Kalmus. The phenotypic frequency of tasters was higher as compared to non-tasters, and the same is statistically significant (χ(2)= 11.92, df = 5, P = 0.036). There were more females among tasters (67.94%) than males (64.76%). This observation was statistically significant (χ(2) = 14.79, df = 5, P = 0.011). The frequency of PTC tasters is greater than non-tasters and the females have lower non-taster pheno-types as compared to males. This type of study will provide background information about genetic structure of population and serves as useful interaction of genetics, food preferences and dietary patterns.

  15. Development of latent fingermarks on surfaces submerged in water: Optimization studies for phase transfer catalyst (PTC) based reagents.

    Science.gov (United States)

    Jasuja, O P; Kumar, Parveen; Singh, Gagandeep

    2015-09-01

    The use of a phase transfer catalyst (PTC) based reagent for the development of latent fingermarks is relatively a recent one and therefore a thorough evaluation is required before making any suggestion for its use in the routine fingermark development protocol. In the present study, non-porous surfaces including the sticky side of adhesive tapes loaded with latent fingermarks (eccrine, groomed and natural fingermarks) were submerged in water for different times and were treated with a PTC based reagent to develop fingermarks. The PTC based reagent was able to develop latent fingermarks on various surfaces submerged in water for different time intervals. The proposed method has been compared with standard methods like superglue fuming, small particle reagent and gentian violet (for adhesive tapes). The results have shown that the duration of submersion and the method selected for visualization have influences on the quality of developed fingermarks. The performance of the PTC technique against conventional methods was evaluated and compared thoroughly as a part of the optimization studies for the reagent. Copyright © 2015 Forensic Science Society. Published by Elsevier Ireland Ltd. All rights reserved.

  16. The ret/ptc1 oncogene is activated in familial adenomatous polyposis-associated thyroid papillary carcinomas.

    Science.gov (United States)

    Cetta, F; Chiappetta, G; Melillo, R M; Petracci, M; Montalto, G; Santoro, M; Fusco, A

    1998-03-01

    Familial adenomatous polyposis (FAP) is caused by germ-line mutations of the apc gene, and it is associated with an increased risk of developing papillary thyroid carcinomas. We have previously reported that a significant fraction of sporadic human papillary thyroid carcinomas is characterized by gene rearrangements affecting the ret protooncogene. These rearrangements generate chimeric transforming oncogenes designated ret/ptc. By a combined immunohistochemical and RT-PCR approach, we analyzed, for ret/ptc oncogene activation, papillary thyroid carcinomas occurred in two FAP kindreds, both showing typical apc gene mutations. Kindred 1 had seven members affected by FAP, and among these, three patients showed papillary thyroid carcinomas. Kindred 2 had two patients, mother and daughter, affected by colonic polyposis; the 20-yr-old daughter showed also a papillary carcinoma. Here we report that ret/ptc1 oncogene was activated in two of the three papillary carcinomas of FAP kindred 1 and in the papillary carcinoma of FAP kindred 2. These findings document that loss of function of apc coexists with gain of function of ret in some papillary thyroid carcinomas, suggesting that ret/ptc1 oncogene activation could be a progression step in the development of FAP-associated thyroid tumors.

  17. PTC simulations, stochastic optimization and safety strategies for groundwater pumping management: case study of the Hersonissos Coastal Aquifer in Crete

    Science.gov (United States)

    Stratis, P. N.; Dokou, Z. A.; Karatzas, G. P.; Papadopoulou, E. P.; Saridakis, Y. G.

    2017-09-01

    Recently, the well-known Princeton Transport Code (PTC), a groundwater flow and contaminant transport simulator, has been coupled with the ALgorithm of Pattern EXtraction (ALOPEX), a real-time stochastic optimization method, to provide a freshwater pumping management tool for coastal aquifers, aiming in preventing saltwater intrusion. In our previous work (Proceedings of INASE/CSCC-WHH 2015, Recent Advances in Environmental and Earth Sciences and Economics, pp 329-334, 2015), the PTC-ALOPEX approach was used in studying the saltwater contamination problem for the coastal aquifer at Hersonissos, Crete. Extending these results, in the present study the PTC-ALOPEX approach is equipped with a nodal safety strategy that effectively controls saltwater front's advancement inside the aquifer. In cooperation with an appropriate penalty system, the performance of PTC-ALOPEX algorithm is studied considering several pumping and weather condition scenarios. This study also establishes pumping/well scenarios that ensure the needed volume of fresh water to the local community without risking saltwater contamination.

  18. Prevalence and Genetic Analysis of Bitter Taste Perception for Phenylthiocarbamide (PTC Among Some Muslim Populations of Uttar Pradesh, India.

    Directory of Open Access Journals (Sweden)

    Ruqaiya Hussain

    2015-04-01

    Full Text Available The ability to taste Phenylthiocarbamide (PTC, a bitter organic compound, described as a bimodal autosomal trait is widely used to know the heritable trait in both genetic and anthropological studies. The present study was carried out to analyze the prevalence of PTC taste sensitivity and to determine the gene frequencies among some Muslim populations of Uttar Pradesh, India. This study has some physiological relevance to highlight the adaptability of endogamous groups to behavioral traits in the same place.Unrelated, healthy individuals of both sexes (Male-403, Female-418 belonging to different populations of Uttar Pradesh, India were randomly selected with the age range of 16-45 years observed for phenylthiocarbamide to taste sensitivity. PTC tasting ability was measured by using a serial dilution method of Harris and Kalmus.The phenotypic frequency of tasters was higher as compared to non-tasters, and the same is statistically significant (χ(2= 11.92, df = 5, P = 0.036. There were more females among tasters (67.94% than males (64.76%. This observation was statistically significant (χ(2 = 14.79, df = 5, P = 0.011.The frequency of PTC tasters is greater than non-tasters and the females have lower non-taster pheno-types as compared to males. This type of study will provide background information about genetic structure of population and serves as useful interaction of genetics, food preferences and dietary patterns.

  19. 10 CFR 431.102 - Definitions concerning commercial water heaters, hot water supply boilers, and unfired hot water...

    Science.gov (United States)

    2010-01-01

    ... attached. Thermal efficiency for an instantaneous water heater, a storage water heater or a hot water... the amount of energy consumed by the water heater as measured during the thermal efficiency test... 10 Energy 3 2010-01-01 2010-01-01 false Definitions concerning commercial water heaters, hot...

  20. An Active Heater Control Concept to Meet IXO Type Mirror Module Thermal-Structural Distortion Requirement

    Science.gov (United States)

    Choi, Michael

    2013-01-01

    Flight mirror assemblies (FMAs) of large telescopes, such as the International X-ray Observatory (IXO), have very stringent thermal-structural distortion requirements. The spatial temperature gradient requirement within a FMA could be as small as 0.05 C. Con ventionally, heaters and thermistors are attached to the stray light baffle (SLB), and centralized heater controllers (i.e., heater controller boards located in a large electronics box) are used. Due to the large number of heater harnesses, accommodating and routing them is extremely difficult. The total harness length/mass is very large. This innovation uses a thermally conductive pre-collimator to accommodate heaters and a distributed heater controller approach. It minimizes the harness length and mass, and reduces the problem of routing and accommodating them. Heaters and thermistors are attached to a short (4.67 cm) aluminum portion of the pre-collimator, which is thermally coupled to the SLB. Heaters, which have a very small heater power density, and thermistors are attached to the exterior of all the mirror module walls. The major portion (23.4 cm) of the pre-collimator for the middle and outer modules is made of thin, non-conductive material. It minimizes the view factors from the FMA and heated portion of the precollimator to space. It also minimizes heat conduction from one end of the FMA to the other. Small and multi-channel heater controllers, which have adjustable set points and internal redundancy, are used. They are mounted to the mechanical support structure members adjacent to each module. The IXO FMA, which is 3.3 m in diameter, is an example of a large telescope. If the heater controller boards are centralized, routing and accommodating heater harnesses is extremely difficult. This innovation has the following advantages. It minimizes the length/mass of the heater harness between the heater controllers and heater circuits. It reduces the problem of routing and accommodating the harness on the

  1. Low dose irradiation of thyroid cells reveals a unique transcriptomic and epigenetic signature in RET/PTC-positive cells

    Energy Technology Data Exchange (ETDEWEB)

    Abou-El-Ardat, Khalil, E-mail: kabouela@sckcen.be [Radiobiology Unit, Molecular and Cellular Biology, GKD Building, Studiecentrum voor Kernenergie - Centre d' Etude de l' Energie Nucleaire (SCK-CEN), Boeretang 200, 2400 Mol (Belgium); Department of Molecular Biotechnology, Faculty of Bioscience Engineering, Universiteit Gent, 9000 Ghent (Belgium); Monsieurs, Pieter [Radiobiology Unit, Molecular and Cellular Biology, GKD Building, Studiecentrum voor Kernenergie - Centre d' Etude de l' Energie Nucleaire (SCK-CEN), Boeretang 200, 2400 Mol (Belgium); Anastasov, Natasa; Atkinson, Mike [Department of Radiation Sciences, Helmholtz Zentrum Muenchen, Munich (Germany); Derradji, Hanane [Radiobiology Unit, Molecular and Cellular Biology, GKD Building, Studiecentrum voor Kernenergie - Centre d' Etude de l' Energie Nucleaire (SCK-CEN), Boeretang 200, 2400 Mol (Belgium); De Meyer, Tim [Department of Molecular Biotechnology, Faculty of Bioscience Engineering, Universiteit Gent, 9000 Ghent (Belgium); Department of Applied Mathematics, Biometrics and Process Control, Faculty of Bioscience Engineering, Universiteit Gent, 9000 Ghent (Belgium); Bekaert, Sofie [Clinical Research Center, Faculty for Medicine and Health Sciences, Universiteit Gent, 185 De Pintelaan, 9000 Ghent (Belgium); Van Criekinge, Wim [Department of Molecular Biotechnology, Faculty of Bioscience Engineering, Universiteit Gent, 9000 Ghent (Belgium); and others

    2012-03-01

    The high doses of radiation received in the wake of the Chernobyl incident and the atomic bombing of Hiroshima and Nagasaki have been linked to the increased appearance of thyroid cancer in the children living in the vicinity of the site. However, the data gathered on the effect of low doses of radiation on the thyroid remain limited. We have examined the genome wide transcriptional response of a culture of TPC-1 human cell line of papillary thyroid carcinoma origin with a RET/PTC1 translocation to various doses (0.0625, 0.5, and 4 Gy) of X-rays and compared it to response of thyroids with a RET/PTC3 translocation and against wild-type mouse thyroids irradiated with the same doses using Affymetrix microarrays. We have found considerable overlap at a high dose of 4 Gy in both RET/PTC-positive systems but no common genes at 62.5 mGy. In addition, the response of RET/PTC-positive system at all doses was distinct from the response of wild-type thyroids with both systems signaling down different pathways. Analysis of the response of microRNAs in TPC-1 cells revealed a radiation-responsive signature of microRNAs in addition to dose-responsive microRNAs. Our results point to the fact that a low dose of X-rays seems to have a significant proliferative effect on normal thyroids. This observation should be studied further as opposed to its effect on RET/PTC-positive thyroids which was subtle, anti-proliferative and system-dependent.

  2. Thermography and Sonic Anemometry to Analyze Air Heaters in Mediterranean Greenhouses

    Directory of Open Access Journals (Sweden)

    Araceli Peña

    2012-10-01

    Full Text Available The present work has developed a methodology based on thermography and sonic anemometry for studying the microclimate in Mediterranean greenhouses equipped with air heaters and polyethylene distribution ducts to distribute the warm air. Sonic anemometry allows us to identify the airflow pattern generated by the heaters and to analyze the temperature distribution inside the greenhouse, while thermography provides accurate crop temperature data. Air distribution by means of perforated polyethylene ducts at ground level, widely used in Mediterranean-type greenhouses, can generate heterogeneous temperature distributions inside the greenhouse when the system is not correctly designed. The system analyzed in this work used a polyethylene duct with a row of hot air outlet holes (all of equal diameter that expel warm air toward the ground to avoid plant damage. We have observed that this design (the most widely used in Almería’s greenhouses produces stagnation of hot air in the highest part of the structure, reducing the heating of the crop zone. Using 88 kW heating power (146.7 W∙m−2 the temperature inside the greenhouse is maintained 7.2 to 11.2 °C above the outside temperature. The crop temperature (17.6 to 19.9 °C was maintained above the minimum recommended value of 10 °C.

  3. Thermography and Sonic Anemometry to Analyze Air Heaters in Mediterranean Greenhouses

    Science.gov (United States)

    López, Alejandro; Valera, Diego L.; Molina-Aiz, Francisco; Peña, Araceli

    2012-01-01

    The present work has developed a methodology based on thermography and sonic anemometry for studying the microclimate in Mediterranean greenhouses equipped with air heaters and polyethylene distribution ducts to distribute the warm air. Sonic anemometry allows us to identify the airflow pattern generated by the heaters and to analyze the temperature distribution inside the greenhouse, while thermography provides accurate crop temperature data. Air distribution by means of perforated polyethylene ducts at ground level, widely used in Mediterranean-type greenhouses, can generate heterogeneous temperature distributions inside the greenhouse when the system is not correctly designed. The system analyzed in this work used a polyethylene duct with a row of hot air outlet holes (all of equal diameter) that expel warm air toward the ground to avoid plant damage. We have observed that this design (the most widely used in Almería's greenhouses) produces stagnation of hot air in the highest part of the structure, reducing the heating of the crop zone. Using 88 kW heating power (146.7 W·m−2) the temperature inside the greenhouse is maintained 7.2 to 11.2 °C above the outside temperature. The crop temperature (17.6 to 19.9 °C) was maintained above the minimum recommended value of 10 °C. PMID:23202025

  4. Thermography and sonic anemometry to analyze air heaters in Mediterranean greenhouses.

    Science.gov (United States)

    López, Alejandro; Valera, Diego L; Molina-Aiz, Francisco; Peña, Araceli

    2012-10-16

    The present work has developed a methodology based on thermography and sonic anemometry for studying the microclimate in Mediterranean greenhouses equipped with air heaters and polyethylene distribution ducts to distribute the warm air. Sonic anemometry allows us to identify the airflow pattern generated by the heaters and to analyze the temperature distribution inside the greenhouse, while thermography provides accurate crop temperature data. Air distribution by means of perforated polyethylene ducts at ground level, widely used in Mediterranean-type greenhouses, can generate heterogeneous temperature distributions inside the greenhouse when the system is not correctly designed. The system analyzed in this work used a polyethylene duct with a row of hot air outlet holes (all of equal diameter) that expel warm air toward the ground to avoid plant damage. We have observed that this design (the most widely used in Almería's greenhouses) produces stagnation of hot air in the highest part of the structure, reducing the heating of the crop zone. Using 88 kW heating power (146.7 W ∙ m(-2)) the temperature inside the greenhouse is maintained 7.2 to 11.2 °C above the outside temperature. The crop temperature (17.6 to 19.9 °C) was maintained above the minimum recommended value of 10 °C.

  5. Residence time distribution (RTD) of particulate foods in a continuous flow pilot-scale ohmic heater.

    Science.gov (United States)

    Sarang, Sanjay; Heskitt, Brian; Tulsiyan, Priyank; Sastry, Sudhir K

    2009-08-01

    The residence time distribution (RTD) of a model particulate-fluid mixture (potato in starch solution) in the ohmic heater in a continuous sterilization process was measured using a radio frequency identification (RFID) methodology. The effect of solid concentration and the rotational speed of the agitators on the RTD were studied. The velocity of the fastest particle was 1.62 times the mean product velocity. In general, particle velocity was found to be greater than the product bulk average velocity. Mean particle residence time (MPRT) increased with an increase in the rotational speed of the agitators (P < 0.05), and no particular trend was observed between the MPRT and the solid concentration. The distribution curves E (theta) were skewed to the right suggesting slow moving zones in the system.

  6. Electrical heater for very-low pressure helium gas

    CERN Document Server

    Benda, V; Vuillierme, B

    1996-01-01

    Testing superconducting magnets for the Large Hadron Collider (LHC) in superfluid helium requires large-capacity refrigeration at 1.8K. At CERN, this is provided by a combination of a cold compressor and a set of warm vacuum pumps capable of handling up to 18g/s at 1 kPa suction pressure. The cold helium vapour, after the cold compressor, is warmed up from about 5K to ambient temperature in a 32 kW electrical heater. The device is designed to operate reliably at flow rates varying from 1 to 18g/s, inlet pressure of 1 kPa to 3 kPa, with pressure drop 100 Pa. Design and construction of the heater, completely realised at CERN, are presented, as well as measured performance. Some technological problems are discussed.

  7. Thermal hydraulic analysis of the annular flow helium heater design

    Science.gov (United States)

    Chen, N. C.; Sanders, J. P.

    1982-05-01

    Core support performance test (CSPT) by use of an existing facility, components flow test loop (CFTL), as part of the high temperature gas cooled reactor (HTGR) application program were conducted. A major objective of the CSPT is to study accelerated corrosion of the core graphite support structure in helium at reactor conditions. Concentration of impurities will be adjusted so that a 6 month test represents the 30 year reactor life. Thermal hydraulic and structural integrity of the graphite specimen, will be studied at high pressure of 7.24 MPa (1050 psi) and high temperature of 1000 deg C in a test vessel. To achieve the required high temperature at the test section, a heater bundle has to be specially designed and properly manufactured. Performance characteristics of the heater which were determined from an analysis based on this design are presented.

  8. DESIGN OF A 500W RESONANT INDUCTION HEATER

    Directory of Open Access Journals (Sweden)

    Bekir Sami SAZAK

    1999-01-01

    Full Text Available In this paper a complete design procedure for a 500W induction heating system is given. An induction heating system basically consists of a coil and a DC/AC inverter. The use of a single switch resonant inverter, which is operated with Discontinuous Conduction Mode (DCM, allows the switching device to turn off under zero current conditions, therefore switching losses are much reduced. This inverter system transforms the DC into AC for the induction heater coil. The proposed coil design method is applicable to a load of any shape so long as the coil surrounds the workpiece. The basis of this method of coil design is the reduction of the induction heater coil and workpiece to their equivalent resistance and inductance.

  9. Development of Exhaust Gas Driven Absorption Chiller-Heater

    Science.gov (United States)

    Inoue, Naoyuki; Endou, Tetsuya; Saito, Kiyoshi; Kawai, Sunao

    Waste heat from co-generation systems are usually recovered by hot water or steam, those are used to drive absorption refrigerators at cooling time, and those are used for heating via heat exchangers at heating time. However waste heat from micro gas turbines are discharged in the form of exhaust gas, it is simple that exhaust gas is directly supplied to absorption chiller-heaters. In the first report we studied cooling cycle, and this second paper, we evaluated various absorption heating cycles for exhaust gas driven absorption chiller-heaters, and adopted one of these cycles for the prototype machine. Also, we experimented with the prototype for wide range condition and got the heating characteristics. Based on the experimental data, we developed a simulation model of the static characteristics, and then studied how to increase the output by limited exhaust gas.

  10. An experimental evaluation of multi-pass solar air heaters

    Energy Technology Data Exchange (ETDEWEB)

    Satcunanathan, S.; Persad, P.

    1980-12-01

    Three collectors of identical dimensions but operating in the single-pass, two-pass and three-pass modes were tested simultaneously under ambient conditions. It was found that the two-pass air heater was consistently better than the single-pass air heater over the day for the range of mass flow rates considered. It was also found that at a mass flow rate of 0.0095 kg s/sup -1/ m/sup -2/, the thermal performances of the two-pass and three-pass collectors were identical, but at higher flow rates the two-pass collector was superior to the three-pass collector, the superiority decreasing with increasing mass flow rate.

  11. Fabrication of light weight radioisotope heater unit hardware components

    Science.gov (United States)

    McNeil, Dennis C.

    1996-03-01

    The Light Weight Radioisotope Heater Unit (LWRHU) is planned to be used on the National Aeronautics and Space Administration (NASA) Cassini Mission, to provide localized thermal energy as strategic locations on the spacecraft. These one watt heater units will support the operation of many on-board instruments that require a specific temperature range to function properly. The system incorporates a fuel pellet encapsulated in a vented metallic clad fabricated from platinum-30% rhodium (Pt-30%Rh) tubing, sheet and foil materials. To complete the package, the clad assemblies are placed inside a combination of graphite components. This report describes the techniques employed by Mound related to the fabrication and sub assembly processes of the LWRHU clad hardware components. Included are details concerning configuration control systems, material procurement and certification, hardware fabrication specifics, and special processes that are utilized.

  12. Field Performance of Heat Pump Water Heaters in the Northeast

    Energy Technology Data Exchange (ETDEWEB)

    Shapiro, Carl [Consortium for Advanced Residential Buildings, Norfolk, CT (United States); Puttagunta, Srikanth [Consortium for Advanced Residential Buildings, Norfolk, CT (United States)

    2016-02-05

    Heat pump water heaters (HPWHs) are finally entering the mainstream residential water heater market. Potential catalysts are increased consumer demand for higher energy efficiency electric water heating and a new Federal water heating standard that effectively mandates use of HPWHs for electric storage water heaters with nominal capacities greater than 55 gallons. When compared to electric resistance water heating, the energy and cost savings potential of HPWHs is tremendous. Converting all electric resistance water heaters to HPWHs could save American consumers 7.8 billion dollars annually ($182 per household) in water heating operating costs and cut annual residential source energy consumption for water heating by 0.70 quads. Steven Winter Associates, Inc. embarked on one of the first in situ studies of these newly released HPWH products through a partnership with two sponsoring electric utility companies, National Grid and NSTAR, and one sponsoring energy efficiency service program administrator, Cape Light Compact. Recent laboratory studies have measured performance of HPWHs under various operating conditions, but publically available field studies have not been as available. This evaluation attempts to provide publicly available field data on new HPWHs by monitoring the performance of three recently released products (General Electric GeoSpring(TM), A.O. Smith Voltex(R), and Stiebel Eltron Accelera(R) 300). Fourteen HPWHs were installed in Massachusetts and Rhode Island and monitored for over a year. Of the 14 units, ten were General Electric models (50 gallon units), two were Stiebel Eltron models (80 gallon units), and two were A.O. Smith models (one 60-gallon and one 80-gallon unit).

  13. Field Performance of Heat Pump Water Heaters in the Northeast

    Energy Technology Data Exchange (ETDEWEB)

    Shapiro, C.; Puttagunta, S.

    2013-08-01

    Heat pump water heaters (HPWHs) are finally entering the mainstream residential water heater market. Potential catalysts are increased consumer demand for higher energy efficiency electric water heating and a new Federal water heating standard that effectively mandates use of HPWHs for electric storage water heaters with nominal capacities greater than 55 gallons. When compared to electric resistance water heating, the energy and cost savings potential of HPWHs is tremendous. Converting all electric resistance water heaters to HPWHs could save American consumers 7.8 billion dollars annually ($182 per household) in water heating operating costs and cut annual residential source energy consumption for water heating by 0.70 quads. Steven Winter Associates, Inc. embarked on one of the first in situ studies of these newly released HPWH products through a partnership with two sponsoring electric utility companies, National Grid and NSTAR, and one sponsoring energy efficiency service program administrator, Cape Light Compact. Recent laboratory studies have measured performance of HPWHs under various operating conditions, but publicly available field studies have not been as available. This evaluation attempts to provide publicly available field data on new HPWHs by monitoring the performance of three recently released products (General Electric GeoSpring(tm), A.O. Smith Voltex(r), and Stiebel Eltron Accelera(r)300). Fourteen HPWHs were installed in Massachusetts and Rhode Island and monitored for over a year. Of the 14 units, ten were General Electric models (50 gallon units), two were Stiebel Eltron models (80 gallon units), and two were A.O. Smith models (one 60-gallon and one 80-gallon unit).

  14. Conasauga near-surface heater experiment. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Krumhansl, J.L.

    1979-11-01

    The Conasauga Experiment was undertaken to begin assessment of the thermomechanical and chemical response of a specific shale to the heat resulting from emplacement of high-level nuclear wastes. Canister-size heaters were implanted in Conasauga shale in Tennessee. Instrumentation arrays wee placed at various depths in drill holes around each heater. The heaters operated for 8 months and, after the first 4 days, were maintained at 385/sup 0/C. Emphasis was on characterizing the thermal and mechanical response of the formation. Conduction was the major mode of heat transport; convection was perceptible only at temperatures above the boiling point of water. Despite dehydration of the shale at higher temperatures, in situ thermal conductivity was essentially constant and not a function of temperature. The mechanical response of the formation was a slight overall expansion, apparently resulting in a general decrease in permeability. Metallurgical observations were made, the stability of a borosilicate glass wasteform simulant was assessed, and changes in formation mineralogy and groundwater composition were documented. In each of these areas, transient nonequilibrium processes occur that affect material stability and may be important in determining the integrity of a repository. In general, data from the test reflect favorably on the use of shale as a disposal medium for nuclear waste.

  15. Performance Analysis and Modeling of Thermally Sprayed Resistive Heaters

    Science.gov (United States)

    Lamarre, Jean-Michel; Marcoux, Pierre; Perrault, Michel; Abbott, Richard C.; Legoux, Jean-Gabriel

    2013-08-01

    Many processes and systems require hot surfaces. These are usually heated using electrical elements located in their vicinity. However, this solution is subject to intrinsic limitations associated with heating element geometry and physical location. Thermally spraying electrical elements directly on surfaces can overcome these limitations by tailoring the geometry of the heating element to the application. Moreover, the element heat transfer is maximized by minimizing the distance between the heater and the surface to be heated. This article is aimed at modeling and characterizing resistive heaters sprayed on metallic substrates. Heaters were fabricated by using a plasma-sprayed alumina dielectric insulator and a wire flame-sprayed iron-based alloy resistive element. Samples were energized and kept at a constant temperature of 425 °C for up to 4 months. SEM cross-sectional observations revealed the formation of cracks at very specific locations in the alumina layer after thermal use. Finite-element modeling shows that these cracks originate from high local thermal stresses and can be predicted according to the considered geometry. The simulation model was refined using experimental parameters obtained by several techniques such as emissivity and time-dependent temperature profile (infra-red camera), resistivity (four-probe technique), thermal diffusivity (laser flash method), and mechanical properties (micro and nanoindentation). The influence of the alumina thickness and the substrate material on crack formation was evaluated.

  16. Tip Heater for Minimum Quench Energy Measurements on Superconducting Strands

    CERN Document Server

    Bauer, P; Oberli, L R

    1999-01-01

    Superconducting strands can be characterized by their Minimum Quench Energy (MQE), i.e. the minimum heat pulse needed to trigger a quench in operation conditions (field, temperature, current), in the limit of a (temporally and spatially) d-shaped disturbance. The sub-mm/µs range of perturbation space has only recently been achieved using the electrical graphite-paste heater technique [1]. The present work has put this technique into practice for the strands of the LHC main magnets, which are designed to operate at 1.9K in peak fields of up to 9T [1]. No way has been found yet to calibrate MQE measurements. To make relative statements on the MQE of different samples possible, the reproducibility of the measurements was emphasized. First heater prototypes did not come up to this stipulation. Finally the tip-heater configuration was found to meet the requirements. It generates a heat pulse in a thin resistive graphite paste deposit on top of a small tip that is pressed against the sample with a clamp. The clamp...

  17. Control and Coordination of Frequency Responsive Residential Water Heaters

    Energy Technology Data Exchange (ETDEWEB)

    Williams, Tess L.; Kalsi, Karanjit; Elizondo, Marcelo A.; Marinovici, Laurentiu D.; Pratt, Richard M.

    2016-07-31

    Demand-side frequency control can complement traditional generator controls to maintain the stability of large electric systems in the face of rising uncertainty and variability associated with renewable energy resources. This paper presents a hierarchical frequency-based load control strategy that uses a supervisor to flexibly adjust control gains that a population of end-use loads respond to in a decentralized manner to help meet the NERC BAL-003-1 frequency response standard at both the area level and interconnection level. The load model is calibrated and used to model populations of frequency-responsive water heaters in a PowerWorld simulation of the U.S. Western Interconnection (WECC). The proposed design is implemented and demonstrated on physical water heaters in a laboratory setting. A significant fraction of the required frequency response in the WECC could be supplied by electric water heaters alone at penetration levels of less than 15%, while contributing to NERC requirements at the interconnection and area levels.

  18. Evaluation of candidate Stirling engine heater tube alloys after 3500 hours exposure to high pressure doped hydrogen or helium

    Science.gov (United States)

    Misencik, J. A.; Titran, R. H.

    1984-01-01

    The heater head tubes of current prototype automotive Stirling engines are fabricated from alloy N-155, an alloy which contains 20 percent cobalt. Because the United States imports over 90 percent of the cobalt used in this country and resource supplies could not meet the demand imposed by automotive applications of cobalt in the heater head (tubes plus cylinders and regenerator housings), it is imperative that substitute alloys free of cobalt be identified. The research described herein focused on the heater head tubes. Sixteen alloys (15 potential substitutes plus the 20 percent Co N-155 alloy) were evaluated in the form of thin wall tubing in the NASA Lewis Research Center Stirling simulator materials diesel fuel fired test rigs. Tubes filled with either hydrogen doped with 1 percent CO2 or with helium at a gas pressure of 15 MPa and a temperature of 820 C were cyclic endurance tested for times up to 3500 hr. Results showed that two iron-nickel base superalloys, CG-27 and Pyromet 901 survived the 3500 hr endurance test. The remaining alloys failed by creep-rupture at times less than 3000 hr, however, several other alloys had superior lives to N-155. Results further showed that doping the hydrogen working fluid with 1 vol % CO2 is an effective means of reducing hydrogen permeability through all the alloy tubes investigated.

  19. A lack of premature termination codon read-through efficacy of PTC124 (Ataluren in a diverse array of reporter assays.

    Directory of Open Access Journals (Sweden)

    Stuart P McElroy

    Full Text Available The drug molecule PTC124 (Ataluren has been described as a read-through agent, capable of suppressing premature termination codons (PTCs and restoring functional protein production from genes disrupted by nonsense mutations. Following the discovery of PTC124 there was some controversy regarding its mechanism of action with two reports attributing its activity to an off-target effect on the Firefly luciferase (FLuc reporter used in the development of the molecule. Despite questions remaining as to its mechanism of action, development of PTC124 continued into the clinic and it is being actively pursued as a potential nonsense mutation therapy. To thoroughly test the ability of PTC124 to read through nonsense mutations, we conducted a detailed assessment comparing the efficacy of PTC124 with the classical aminoglycoside antibiotic read-through agent geneticin (G418 across a diverse range of in vitro reporter assays. We can confirm the off-target FLuc activity of PTC124 but found that, while G418 exhibits varying activity in every read-through assay, there is no evidence of activity for PTC124.

  20. An examination of associations between the inability to taste phenylthiocarbamide (PTC) and clinical characteristics and trait markers in first-episode, nonaffective psychotic disorders.

    Science.gov (United States)

    Compton, Michael T; Ionescu, Dawn F; Broussard, Beth; Cristofaro, Sarah L; Johnson, Stephanie; Haggard, Patrick J; Potts, Amy A; Wan, Claire Ramsay; Walker, Elaine F

    2013-08-30

    Research findings are mixed as to whether or not the inability to taste phenylthiocarbamide (PTC) might represent an endophenotypic trait marker for schizophrenia. We hypothesized associations between PTC-tasting status and select clinical characteristics and trait markers in patients with psychotic disorders that, if present, would provide support for the inability to taste PTC as a trait marker. In a first-episode psychosis sample (n=93), we measured PTC tasting, family history of psychosis, age at onset of prodrome and psychosis, severity of positive and negative symptoms, global impairment in functioning, neurological soft signs, and four neurocognitive domains (verbal learning/memory, visual learning/memory, verbal working memory, and spatial working memory). Associations between PTC-non-tasting and clinical/neurocognitive variables were examined with χ(2) tests and independent samples t tests. Among participants, 67.7% tasted PTC in comparison to a strip of control paper, and 25.8% were non-tasters. Tasters and non-tasters did not show statistically significant differences with respect to family history, age at onset, severity of symptoms, neurological soft signs, or the four neurocognitive domains. In conjunction with other findings, it is unlikely that PTC-non-tasting is a trait marker of schizophrenia, though a conclusive study is warranted. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  1. A lack of premature termination codon read-through efficacy of PTC124 (Ataluren) in a diverse array of reporter assays.

    Science.gov (United States)

    McElroy, Stuart P; Nomura, Toshifumi; Torrie, Leah S; Warbrick, Emma; Gartner, Ulrike; Wood, Gavin; McLean, W H Irwin

    2013-01-01

    The drug molecule PTC124 (Ataluren) has been described as a read-through agent, capable of suppressing premature termination codons (PTCs) and restoring functional protein production from genes disrupted by nonsense mutations. Following the discovery of PTC124 there was some controversy regarding its mechanism of action with two reports attributing its activity to an off-target effect on the Firefly luciferase (FLuc) reporter used in the development of the molecule. Despite questions remaining as to its mechanism of action, development of PTC124 continued into the clinic and it is being actively pursued as a potential nonsense mutation therapy. To thoroughly test the ability of PTC124 to read through nonsense mutations, we conducted a detailed assessment comparing the efficacy of PTC124 with the classical aminoglycoside antibiotic read-through agent geneticin (G418) across a diverse range of in vitro reporter assays. We can confirm the off-target FLuc activity of PTC124 but found that, while G418 exhibits varying activity in every read-through assay, there is no evidence of activity for PTC124.

  2. Prevalence of RET/PTC expression in papillary thyroid carcinoma and its correlation with prognostic factors in a north Indian population.

    Science.gov (United States)

    Mishra, A; Agrawal, V; Krishnani, N; Mishra, S K

    2009-01-01

    The prevalence of Rearranged during Transfection/Papillary Thyroid Carcinoma (RET/PTC) rearrangement in papillary thyroid carcinoma (PTC) varies in different geographic regions and its prognostic significance remains unclear. The aim of this study was to recognize the prevalence of RET/PTC expression in PTC from the endemically iodine-deficient region in Northern India and to correlate the expression with the clinicopathologic prognostic factors. Retrospective. Archival tissue used. Immunohistochemistry was performed to look for activated RET protein expression in 50 cases of PTC. No patient had any history of prior irradiation. Chi-square method, Student t test, and binary regression method. A P value of PTC (47.5%), followed by tumors with poorly differentiated areas (25%) and follicular variant (16.7%). RET expression was more prevalent in young patients (45.5 vs. 35.3%), females (43.3 vs. 40.0%), small tumors (33.3 vs. 26.7%), multicentric tumors (36.8 vs. 33.3%), tumors with extrathyroidal invasion (38.9 vs. 32.4%), and regional lymphadenopathy (55.2 vs. 22.2%), while it was less in cases with distant metastases (20 vs. 43.9%). There was no significant correlation of immunoreactivity with any prognostic factor. However, when the cases having immunoreactivity within histiocytes (n=26) and histiocytes + tumor tissue (n=28) were considered, then the expression was significantly more in cases with lymphadenopathy (P values=.009, in both instances). However, the exact clinical significance of RET/PTC positive histiocytes remained unexplained. Prevalence of RET/PTC in our study was consistent with the reported prevalence from other geographic areas. There was no significant correlation with the clinicopathologic factors. However, uniform techniques of detection and large international collaborative studies could clear the uncertainties regarding the prognostic importance of RET/PTC.

  3. Promotion effect of manganese oxide on the electrocatalytic activity of Pt/C for methanol oxidation in acid medium

    Energy Technology Data Exchange (ETDEWEB)

    Abdel Hameed, R.M., E-mail: randa311eg@yahoo.com [Chemistry Department, Faculty of Science, Cairo University, Giza (Egypt); Fetohi, Amani E.; Amin, R.S.; El-Khatib, K.M. [Chemical Engineering Department, National Research Center, Dokki, Giza (Egypt)

    2015-12-30

    Graphical abstract: Physical and electrochemical properties of Pt/C, Pt–MnO{sub 2}/C-1 and Pt–MnO{sub 2}/C-2 electrocatalysts. - Highlights: • Adding MnO{sub 2} to Pt/C improved the dispersion of Pt nanoparticles. • The existence of MnO{sub 2} improved the kinetics of methanol oxidation reaction. • R{sub ct} value of Pt–MnO{sub 2}/C was about 10 times as low as that at Pt/C. • The removal of CO{sub ads} poisoning species was facilitated at Pt–MnO{sub 2}/C. - Abstract: The modification of Pt/C by incorporating metal oxides for electrocatalytic oxidation of methanol has gained major attention because of the efficiency loss during the course of long-time operation. This work describes the preparation of Pt–MnO{sub 2}/C electrocatalysts through a chemical route using ethylene glycol or a mixture of ethylene glycol and sodium borohydride as a reducing agent. The crystallite structure and particle size of synthesized electrocatalysts are determined using X-ray diffraction (XRD) and transmission electron microscopy (TEM). The addition of MnO{sub 2} improves the dispersion of Pt nanoparticles. The electrocatalytic activity of Pt–MnO{sub 2}/C towards methanol oxidation in H{sub 2}SO{sub 4} solution is investigated using cyclic voltammetry and electrochemical impedance spectroscopy. The onset potential value of methanol oxidation peak is negatively shifted by 169 mV when MnO{sub 2} is introduced to Pt/C. Moreover, the charge transfer resistance value at Pt–MnO{sub 2}/C is about 10 times as low as that at Pt/C. Chronoamperometry and chronopotentiometry show that CO tolerance is greatly improved at Pt–MnO{sub 2}/C. The increased electrocatalytic activity and enhanced ability to clean platinum surface elect manganese oxide as a suitable promoter for the anode performance in direct methanol fuel cells (DMFCs).

  4. Four Bed Molecular Sieve - Exploration (4BMS-X) Virtual Heater Design and Optimization

    Science.gov (United States)

    Schunk, R. Gregory; Peters, Warren T.; Thomas, John T., Jr.

    2017-01-01

    A 4BMS-X (Four Bed Molecular Sieve - Exploration) design and heater optimization study for CO2 sorbent beds in proposed exploration system architectures is presented. The primary objectives of the study are to reduce heater power and thermal gradients within the CO2 sorbent beds while minimizing channeling effects. Some of the notable changes from the ISS (International Space Station) CDRA (Carbon Dioxide Removal Assembly) to the proposed exploration system architecture include cylindrical beds, alternate sorbents and an improved heater core. Results from both 2D and 3D sorbent bed thermal models with integrated heaters are presented. The 2D sorbent bed models are used to optimize heater power and fin geometry while the 3D models address end effects in the beds for more realistic thermal gradient and heater power predictions.

  5. 接枝炭黑/聚乙烯导电复合材料正电阻温度系数(PTC)效应研究%Study on PTC Characteristics in Grafting Carbon Black/Polyethylene Conductive Composites

    Institute of Scientific and Technical Information of China (English)

    李勇; 路庆华

    2001-01-01

    用接枝炭黑作导电粒子研究了在聚乙烯基材中的正(电阻)温度系数(PTC)效应。结果发现,甲基丙烯酸甲酯接枝的炭黑在高密度聚乙烯中能表现出较好的PTC效应。从实验现象分析,接枝炭黑的PTC效应是结晶熔融和体积膨胀双重变化共同作用的结果。%Composites based on grafting carbon black/polyethylene were prepared to study the positivetemperature coefficients properties. The effects of various grafting CB for conductive particles in the PTCcomposites were investigated. It showed that PTC properties of MMA-g-CB/HDPE composites were im-proved. The mechanism of PTC effects in the grafting carbon black/polyethylene are the results of crystalmelting and volume expandsion.

  6. Assessing the Energy Savings of Tankless Water Heater Retrofits in Public Housing

    Energy Technology Data Exchange (ETDEWEB)

    Ries, R.; Walters, R.; Dwiantoro, D.

    2013-01-01

    This report describes the methodology, analysis, and findings from a case study of a 110 unit retrofit of gas tankless water heaters in a hot/humid climate in Alachua County, Florida. The housing units had their gas-fired tank type water heaters replaced with gas-fired tankless water heaters as part of a federal program that targeted reduced energy use in public housing.

  7. Assessing the Energy Savings of Tankless Water Heater Retrofits in Public Housing

    Energy Technology Data Exchange (ETDEWEB)

    Ries, R. [Univ. of Florida, Gainesville, FL (United States). Building Energy Efficient Housing for America (BEEHA)Team; Walters, R. [Univ. of Florida, Gainesville, FL (United States). Building Energy Efficient Housing for America (BEEHA)Team; Dwiantoro, D. [Univ. of Florida, Gainesville, FL (United States). Building Energy Efficient Housing for America (BEEHA)Team

    2013-01-01

    This report describes the methodology, analysis, and findings from a case study of a 110 unit retrofit of gas tankless water heaters in a hot/humid climate in Alachua County, Florida.The gas-fired tank type water heaters in the housing units were replaced with gas-fired tankless water heaters as part of a federal program that targeted reduced energy use in public housing.

  8. Comparison of Simulation and Experimental Results of Class - D Inverter Fed Induction Heater

    Directory of Open Access Journals (Sweden)

    S. Rama Reddy

    2010-10-01

    Full Text Available This research deals w ith simulation and experimentation of closed loop controlled class-D inverter fed induction heater system. This converter has reduced switching losses, stress and increased power density. The inverter system is designed and the simulation is done using Matlab. The results of simulation and experimentation are presented. The induction heater system uses embedded controller to generate driving pulses. The objective is to develop an induction heater system with minimum hardware.

  9. Thermal performance optimization of a flat plate solar air heater using genetic algorithm

    Energy Technology Data Exchange (ETDEWEB)

    Varun; Siddhartha [Department of Mechanical Engineering, National Institute of Technology, Hamirpur 177 005 (H.P.) (India)

    2010-05-15

    Thermal performance of solar air heater is low and different techniques are adopted to increase the performance of solar air heaters, such as: fins, artificial roughness etc. In this paper an attempt has been done to optimize the thermal performance of flat plate solar air heater by considering the different system and operating parameters to obtain maximum thermal performance. Thermal performance is obtained for different Reynolds number, emissivity of the plate, tilt angle and number of glass plates by using genetic algorithm. (author)

  10. Characterization of a thermal power plant air heater washing waste: a case study from Iran.

    Science.gov (United States)

    Saeedi, M; Amini, H R

    2007-02-01

    In Iran most of the electricity is generated by thermal power plants. As a result of fuel oil burning in winter time, the air heaters of the boilers have to be washed and cleaned frequently. The wastewater originating from air heater washing is then treated in an effluent treatment plant by chemical precipitation followed by dewatering of the sludge produced. The resulting waste is classified as specific industrial waste that should be characterized in detail under the Waste Management Act of Iran. The quantity of this waste produced in the studied power plant is about 20 tonnes year(-1). In the present investigation, the first to be carried out in Iran, seven composite samples of dewatered sludge from air heater washing wastewater treatment were subjected to investigation of the physical properties, chemical composition and leaching properties. The most likely pollutants that were of concern in this study were heavy and other hazardous metals (Cd, Co, Cr, Mn, Ni, Pb, Zn and V). The results revealed that mean pH, wet and dry density and moisture content of the waste were 6.31, 1532 kg m(-30, 1879 kg m(-3) and 15.35%, respectively. Magnetite, SiO2, P2O5, CaO, Al2O3 and MgO were the main constituents of the waste with a weight percentage order of 68.88, 5.91, 3.39, 2.64, 2.59 and 1.76%, respectively. The toxicity characteristic leaching procedure test results for some heavy and other hazardous metals showed that mean elemental concentrations of Cd, Co, Cr, Mn, Ni, Pb, V and Zn in leachate were 0.06, 1.55, 5.49, 36.32, 209.10, 0.58, 314.06 and 24.84 mg L(-1), respectively. According to the Waste Management Act of Iran this waste should be classified as hazardous and should be disposed of in accordance with hazardous waste disposal regulations.

  11. Modifications and Modelling of the Fission Surface Power Primary Test Circuit (FSP-PTC)

    Science.gov (United States)

    Garber, Ann E.

    2008-01-01

    An actively pumped alkali metal flow circuit, designed and fabricated at the NASA Marshall Space Flight Center, underwent a range of tests at MSFC in early 2007. During this period, system transient responses and the performance of the liquid metal pump were evaluated. In May of 2007, the circuit was drained and cleaned to prepare for multiple modifications: the addition of larger upper and lower reservoirs, the installation of an annular linear induction pump (ALIP), and the inclusion of the Single Flow Cell Test Apparatus (SFCTA) in the test section. Performance of the ALIP, provided by Idaho National Laboratory (INL), will be evaluated when testing resumes. The SFCTA, which will be tested simultaneously, will provide data on alkali metal flow behavior through the simulated core channels and assist in the development of a second generation thermal simulator. Additionally, data from the first round of testing has been used to refine the working system model, developed using the Generalized Fluid System Simulation Program (GFSSP). This paper covers the modifications of the FSP-PTC and the updated GFSSP system model.

  12. Capabilities and Testing of the Fission Surface Power Primary Test Circuit (FSP-PTC)

    Science.gov (United States)

    Garber, Anne E.

    2007-01-01

    An actively pumped alkali metal flow circuit, designed and fabricated at the NASA Marshall Space Flight Center, is currently undergoing testing in the Early Flight Fission Test Facility (EFF-TF). Sodium potassium (NaK), which was used in the SNAP-10A fission reactor, was selected as the primary coolant. Basic circuit components include: simulated reactor core, NaK to gas heat exchanger, electromagnetic (EM) liquid metal pump, liquid metal flowmeter, load/drain reservoir, expansion reservoir, test section, and instrumentation. Operation of the circuit is based around a 37-pin partial-array core (pin and flow path dimensions are the same as those in a full core), designed to operate at 33 kWt. NaK flow rates of greater than 1 kg/sec may be achieved, depending upon the power applied to the EM pump. The heat exchanger provides for the removal of thermal energy from the circuit, simulating the presence of an energy conversion system. The presence of the test section increases the versatility of the circuit. A second liquid metal pump, an energy conversion system, and highly instrumented thermal simulators are all being considered for inclusion within the test section. This paper summarizes the capabilities and ongoing testing of the Fission Surface Power Primary Test Circuit (FSP-PTC).

  13. Modifications and Modelling of the Fission Surface Power Primary Test Circuit (FSP-PTC)

    Science.gov (United States)

    Garber, Ann E.

    2008-01-01

    An actively pumped alkali metal flow circuit, designed and fabricated at the NASA Marshall Space Flight Center, underwent a range of tests at MSFC in early 2007. During this period, system transient responses and the performance of the liquid metal pump were evaluated. In May of 2007, the circuit was drained and cleaned to prepare for multiple modifications: the addition of larger upper and lower reservoirs, the installation of an annular linear induction pump (ALIP), and the inclusion of the Single Flow Cell Test Apparatus (SFCTA) in the test section. Performance of the ALIP, provided by Idaho National Laboratory (INL), will be evaluated when testing resumes. The SFCTA, which will be tested simultaneously, will provide data on alkali metal flow behavior through the simulated core channels and assist in the development of a second generation thermal simulator. Additionally, data from the first round of testing has been used to refine the working system model, developed using the Generalized Fluid System Simulation Program (GFSSP). This paper covers the modifications of the FSP-PTC and the updated GFSSP system model.

  14. Enhancement of anodic oxidation of formic acid on palladium decorated Pt/C catalyst

    Science.gov (United States)

    Wu, Yan Ni; Liao, Shi Jun; Su, Yun Lan; Zeng, Jian Huang; Dang, Dai

    A palladium decorated Pt/C catalyst, Pt@Pd/C, is prepared by a colloidal approach with a small amount of platinum as core. It is found that the catalyst shows excellent activity towards anodic oxidation of formic acid at room temperature and its activity is 60% higher than that of Pd/C. Decoration of palladium shell on the platinum core is supported by XPS results. Due to the use of platinum as core, active components are dispersed very well and the particle sizes are smaller than those of Pd/C. The cyclic voltammetry measurement clearly shows synthetic electro-oxidation effects of formic acid on Pt@Pd/C. It is speculated that the high performance of Pt@Pd/C may result from the unique core-shell structure and synergistic effect of Pt and Pd at the interface. The preparation method for Pt@Pd/C reported in this work will provide additional options for the design of catalysts for direct formic acid fuel cell (DFAFC).

  15. Targeting of BMI-1 with PTC-209 shows potent anti-myeloma activity and impairs the tumour microenvironment

    Directory of Open Access Journals (Sweden)

    Arnold Bolomsky

    2016-03-01

    Full Text Available Abstract Background The polycomb complex protein BMI-1 (BMI-1 is a putative oncogene reported to be overexpressed in multiple myeloma (MM. Silencing of BMI-1 was shown to impair the growth and survival of MM cells. However, therapeutic agents specifically targeting BMI-1 were not available so far. Here, we investigated PTC-209, a novel small molecule inhibitor of BMI-1, for its activity in MM. Methods BMI-1 expression was analysed in human MM cell lines and primary MM cells by using publically available gene expression profiling (GEP data. The anti-MM activity of PTC-209 was investigated by viability testing, cell cycle analysis, annexin V and 7-AAD staining, quantification of cleaved poly(ADP-ribose polymerase (PARP, JC-1 as well as colony formation assays. Deregulation of central myeloma growth and survival genes was studied by quantitative PCR and flow cytometry, respectively. In addition, the impact of PTC-209 on in vitro osteoclast, osteoblast and tube formation was analysed. Results We confirmed overexpression of BMI-1 in MM patients by using publically available GEP datasets. Of note, BMI-1 expression was further increased at relapse which translated into significantly shorter overall survival in relapsed/refractory patients treated with bortezomib or dexamethasone. Treatment with PTC-209 significantly decreased viable cell numbers in human MM cell lines, induced a G1 cell cycle arrest, promoted apoptosis and demonstrated synergistic activity with pomalidomide and carfilzomib. The anti-MM activity of PTC-209 was accompanied by a significant decrease of cyclin D1 (CCND1 and v-myc avian myelocytomatosis viral oncogene homolog (MYC expression as well as upregulation of cyclin-dependent kinase inhibitor 1A (CDKN1A and cyclin-dependent kinase inhibitor 1B (CDKN1B. We also observed upregulation of NOXA (up to 3.6 ± 1.2-fold induction, P = 0.009 and subsequent downregulation of myeloid cell leukemia 1 (MCL-1 protein levels, which likely

  16. PTC-6 vacuum system: WallWalker{trademark} and Blastrac{reg_sign} shot blast cleaning system

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-02-01

    The LTC Americas, Inc. wall decontamination technology consisted of two pneumatic hand-held tools: (1) a roto-peen scaler that used star cutters and (2) a 3-piston hammer with reciprocating bits. The hand-held tools were used in conjunction with the LTC PTC-6 vacuum system which captured dust and debris as the wall decontamination took place. Recommendations for improved worker safety and health during use of the PTC-6 vacuum system with hand-held tools include: (1) keeping all hoses and lines as orderly as possible in compliance with good housekeeping requirements; (2) ergonomic training to include techniques in lifting, bending, stooping, twisting, etc.; (3) use of a clamping system to hold hoses to the vacuum system; (4) a safety line on the air line connections; (5) use of a mechanical lifting system for waste drum removal; and (6) the use of ergonomically designed tools.

  17. Boiling Heat Transfer in High Temperature Generator of Absorption Chiller/Heater

    Science.gov (United States)

    Furukawa, Masahiro; Enomoto, Eiichi; Sekoguchi, Kotohiko

    The heat transfer performance of forced convective boiling was tested using a high temperature generator of absorption chiller/heater, the rear furnace wall of which was composed of two different surfaces; i. e., plain and sprayed heated surfaces. These two surfaces were bisymmetrically set. Wall surface temperatures of both the fire and fluid sides were measured at three locations along the upward flow direction in each heated surface for determining the heat flux and heat transfer coefficient. Nickel-chromium and alumina were employed as the spray materials. The test results show that the sprayed surface can yield a marked elevation in the heat transfer performance due to boiling on the plain surface. Therefore the level of heated surface temperature is largely reduced by means of the spraying surface treatment. This implies that the spraying would much improve a corrosive condition of the heated surface.

  18. A constitutive active MAPK/ERK pathway due to BRAFV600E positively regulates AHR pathway in PTC

    OpenAIRE

    Occhi, Gianluca; Barollo, Susi; Regazzo, Daniela; Bertazza, Loris; Galuppini, Francesca; Guzzardo, Vincenza; Jaffrain-Rea, Marie Lise; Vianello, Federica; Ciato, Denis; Ceccato, Filippo; Watutantrige-Fernando, Sara; Bisognin, Andrea; Bortoluzzi, Stefania; Pennelli, Gianmaria; Boscaro, Marco

    2015-01-01

    The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor mediating the toxicity and tumor-promoting properties of dioxin. AHR has been reported to be overexpressed and constitutively active in a variety of solid tumors, but few data are currently available concerning its role in thyroid cancer. In this study we quantitatively explored a series of 51 paired-normal and papillary thyroid carcinoma (PTC) tissues for AHR-related genes. We identified an increased AHR expressio...

  19. Expression of zebrafish hip: response to Hedgehog signalling, comparison with ptc1 expression, and possible role in otic patterning.

    Science.gov (United States)

    Hammond, Katherine L; Whitfield, Tanya T

    2009-09-01

    In zebrafish, Hedgehog (Hh) signalling is required to specify posterior otic identity. This presents a conundrum, as the nearest source of Hh to the developing inner ear is the ventral midline, in the notochord and floorplate. How can a source of Hh that is ostensibly constant with respect to the anteroposterior axis of the otic vesicle specify posterior otic identity? One possibility is that localised inhibition of Hh signalling is involved. Here we show that genes coding for three inhibitors of Hh signalling, su(fu), dzip1 and hip, are expressed in and around the developing otic vesicle. su(fu) and dzip1 are ubiquitously expressed and unaffected by Hh levels. The expression of hip, however, is positively regulated by Hh signalling and has a complex, dynamic pattern. It is detectable in the neural tube, otic vesicle, statoacoustic ganglion, brain, fin buds, mouth, somites, pronephros and branchial arches. These expression domains bear some similarity, but are not identical, to those of ptc1, a Hh receptor gene that is also positively regulated by Hh signalling. In the neural tube, for instance, hip is expressed in a subset of the ptc1 expression domain, while in other regions, including the otic vesicle, hip and ptc1 expression domains differ. Significantly, we find that initial expression of hip is higher in and adjacent to anterior otic regions, while ptc1 expression becomes progressively restricted to the posterior of the ear. Hip-mediated inhibition of Hh signalling may therefore be important in restricting the effects of Hh to posterior regions of the developing inner ear.

  20. Characteristics and Applied Limits for the Test Code ASME PTC 6.2 of Steam Turbine Performance%汽轮机性能试验规程ASME PTC6.2的特点及适用范围

    Institute of Scientific and Technical Information of China (English)

    刘利; 张敏

    2011-01-01

    对美国机械工程师学会制定的试验规程ASME PTC 6.2中蒸汽轮机的试验特点和试验方法等(联合循环)进行了系统阐述.ASME PTC 6.2规程具有边界条件、二元加法修正法等特点,适用于各种形式联合循环中汽轮机性能试验.将ASME PTC 6.2、ASME PTC 6和ASME PTC 46规程进行了比较分析,指出了规程的适用范围,得出了相关结论.

  1. Identification of a PTC-containing DlRan transcript and its differential expression during somatic embryogenesis in Dimocarpus longan.

    Science.gov (United States)

    Fang, Zhi-Zhen; Lai, Cheng-Chun; Zhang, Ya-Ling; Lin, Yu-Ling; Lai, Zhong-Xiong

    2013-10-15

    RAN (Ras-related nuclear protein) plays crucial roles in multiple cellular processes in yeast, animals and plants. Here we present a DlRan gene and its alternative splicing transcripts containing premature terminator codons (PTCs), identified from embryogenic cultures in longan. Multiple alignment and splicing pattern analyses indicated that DlRan-1 transcript harboring PTC was the consequence of alternative splicing. The accumulation of DlRan PTC-containing transcripts increased significantly when the embryogenic calli were treated with the translation inhibitor, cycloheximide, indicating that DlRan-1 may be targeted by NMD. The analysis of expression profiles of DlRan transcripts revealed that differential expression levels of the alternative spliced DlRan transcripts occurred during the development of embryogenic callus, globular-shaped embryos, and cotyledon-shaped embryos, respectively, in the longan somatic embryogenesis, and were in consistent with the embryo development in corresponding wild-type transcripts. The present work offers evidence to speculate that the alternatively spliced PTC-containing transcripts can be functional and may shed light on expression regulation of DlRan during development of the longan somatic embryos. © 2013 Elsevier B.V. All rights reserved.

  2. Aminoglycosides, but not PTC124 (Ataluren), rescue nonsense mutations in the leptin receptor and in luciferase reporter genes.

    Science.gov (United States)

    Bolze, Florian; Mocek, Sabine; Zimmermann, Anika; Klingenspor, Martin

    2017-04-21

    In rare cases, monogenetic obesity is caused by nonsense mutations in genes regulating energy balance. A key factor herein is the leptin receptor. Here, we focus on leptin receptor nonsense variants causing obesity, namely the human W31X, murine Y333X and rat Y763X mutations, and explored their susceptibilities to aminoglycoside and PTC124 mediated translational read-through in vitro. In a luciferase based assay, all mutations - when analysed within the mouse receptor - were prone to aminoglycoside mediated nonsense suppression with the highest susceptibility for W31X, followed by Y763X and Y333X. For the latter, the corresponding rodent models appear valuable for in vivo experiments. When W31X was studied in the human receptor, its superior read-through susceptibility - initially observed in the mouse receptor - was eliminated, likely due to the different nucleotide context surrounding the mutation in the two orthologues. The impact of the surrounding context on the read-through opens the possibility to discover novel sequence elements influencing nonsense suppression. As an alternative to toxic aminoglycosides, PTC124 was indicated as a superior nonsense suppressor but inconsistent data concerning its read-through activity are reported. PTC124 failed to rescue W31X as well as different nonsense mutated luciferase reporters, thus, challenging its ability to induce translational read-through.

  3. The heater test at the Grimsel Rock Laboratory: The thermo-mechanical response of the rock mass to a heat flux

    Energy Technology Data Exchange (ETDEWEB)

    Schneefuss, J.; Gommlich, G.; Noell, U. (Gesellschaft fuer Strahlen- und Umweltforschung m.b.H. Muenchen, Braunschweig (Germany, F.R.). Inst. fuer Tieflagerung)

    1989-08-01

    The Grimsel Test Site (Felslabor Grimsel - FLG) is situated at a depth of 450 m in the Juchlistock massif of the Bernese Oberland. It is managed by the National Cooperative for the Storage of Radioactive Waste (NAGRA-Switzerland). By means of a heater test, the power output of canisters filled with high-level waste is simulated. This heater test is performed by the German Gesellschaft fuer Strahlen- und Umweltforschung - GSF. Two electrical heaters, with a heatable length of 6 m, a diameter of 0.3 m and an available power of 4 kW/m, are installed in two vertical boreholes. One of them is located in the granite adjacent to a strongly fractured lamprophyre vein, the other one directly within this disturbed zone. They are operating since August 1986. The thermo-mechanical reaction of the rock mass is registered by a large number of measurement devices which are installed in an array of instrument boreholes around the heaters. They record the deformation and the alteration of rock stresses, the pore water pressure and the water conductivity caused by heating. (orig.).

  4. The correlation between BRAF mutations, RET/PTC rearrangements and platelet-derived growth factor B expression in papillary thyroid carcinomas

    Institute of Scientific and Technical Information of China (English)

    王萍

    2013-01-01

    Objective To investigate the prevalence of BRAF T1799A mutation and RET/PTC rearrangement in Qingdao and detect the expression of platelet-derived growth factor B(PDGF-B) in order to investigate the correlation

  5. Phenylthiocarbamide (PTC) perception in patients with schizophrenia and first-degree family members: relationship to clinical symptomatology and psychophysical olfactory performance.

    Science.gov (United States)

    Moberg, Paul J; McGue, Colleen; Kanes, Stephen J; Roalf, David R; Balderston, Catherine C; Gur, Raquel E; Kohler, Christian G; Turetsky, Bruce I

    2007-02-01

    The inability to taste phenylthiocarbamide (PTC; "taste-blindness") has been associated with a number of medical and neurological illnesses not typically related to taste. We examined PTC sensitivity in 67 schizophrenia patients, 30 healthy controls, and 30 first-degree relatives to determine whether taster status could represent a simple vulnerability marker. A higher prevalence of non-tasters was seen in patients and family members relative to healthy controls. Among patients, non-tasters exhibited increased levels of negative and first-rank symptoms as well as poorer right nostril odor identification skills relative to PTC tasters. These differences were not explained by age, sex, education, smoking, or intensity differences. Phenotypic variation in PTC sensitivity is thought to be genetic in origin and suggests greater illness risk for those subjects with recessive taster alleles.

  6. Zoned electrical heater arranged in spaced relationship from particulate filter

    Science.gov (United States)

    Gonze, Eugene V [Pinckney, MI

    2011-11-15

    A system comprises a particulate matter (PM) filter that comprises an upstream end for receiving exhaust gas and a downstream end. A zoned heater is arranged spaced from the upstream end and comprises N zones, where N is an integer greater than one, wherein each of the N zones comprises M sub-zones, where M is an integer greater than one. A control module selectively activates at least a selected one of the N zones to initiate regeneration in downstream portions of the PM filter from the one of the N zones and deactivates non-selected ones of the N zones.

  7. Exergetic performance evaluation and parametric studies of solar air heater

    Energy Technology Data Exchange (ETDEWEB)

    Gupta, M.K.; Kaushik, S.C. [Centre for Energy Studies, Indian Institute of Technology, Delhi 110016 (India)

    2008-11-15

    The present study aims to establish the optimal performance parameters for the maximum exergy delivery during the collection of solar energy in a flat-plate solar air heater. The procedure to determine optimum aspect ratio (length to width ratio of the absorber plate) and optimum duct depth (the distance between the absorber and the bottom plates) for maximum exergy delivery has been developed. It is known that heat energy gain and blower work increase monotonically with mass flow rate, while the temperature of air decreases; therefore, it is desirable to incorporate the quality of heat energy collected and the blower work. First it is proved analytically that the optimum exergy output, neglecting blower work, and the corresponding mass flow rate depend on the inlet temperature of air. The energy and exergy output rates of the solar air heater were evaluated for various values of collector aspect ratio (AR) of the collector, mass flow rate per unit area of the collector plate (G) and solar air heater duct depth (H). Results have been presented to discuss the effects of G, AR and H on the energy and exergy output rates of the solar air heater. The energy output rate increases with G and AR, and decreases with H and the inlet temperature of air. The exergy-based evaluation criterion shows that performance is not a monotonically increasing function of G and AR, and a decreasing function of H and inlet temperature of air. Based on the exergy output rate, it is found that there must be an optimum inlet temperature of air and a corresponding optimum G for any value of AR and H. For values of G lesser than optimal corresponding to inlet temperature of air equals to ambient, higher exergy output rate is achieved for the low value of duct depth and high AR in the range of parameters investigated. If G is high, for an application requiring less temperature increase, then either low AR or high H would give higher exergy output rate. (author)

  8. High Efficiency R-744 Commercial Heat Pump Water Heaters

    Energy Technology Data Exchange (ETDEWEB)

    Elbel, Dr. Stefan W.; Petersen, Michael

    2013-04-25

    The project investigated the development and improvement process of a R744 (CO2) commercial heat pump water heater (HPWH) package of approximately 35 kW. The improvement process covered all main components of the system. More specific the heat exchangers (Internal heat exchanger, Evaporator, Gas cooler) as well as the expansion device and the compressor were investigated. In addition, a comparison to a commercially available baseline R134a unit of the same capacity and footprint was made in order to compare performance as well as package size reduction potential.

  9. Thin film heater for removable volatile protecting coatings.

    Science.gov (United States)

    Karim, Abid

    2013-01-01

    Freshly coated aluminum mirrors have excellent reflectivity at far ultraviolet wavelengths. However, reflectivity rapidly degrades when the mirror surfaces are exposed to atmosphere. In order to avoid this problem, freshly coated aluminum surface can be protected by over-coating of a removable volatile protecting coating. This protecting coating can be re-evaporated by controlled heating or by some other methods when required. This type of removable coating has immediate application in UV space astronomy. The purpose of this paper is to demonstrate the feasibility of re-evaporation of removable volatile Zn protecting coating using a NiCr thin film heater without affecting the reflection properties of Al mirror surfaces.

  10. Benchmark Tests for Stirling Convertor Heater Head Life Assessment Conducted

    Science.gov (United States)

    Krause, David L.; Halford, Gary R.; Bowman, Randy R.

    2004-01-01

    A new in-house test capability has been developed at the NASA Glenn Research Center, where a critical component of the Stirling Radioisotope Generator (SRG) is undergoing extensive testing to aid the development of analytical life prediction methodology and to experimentally aid in verification of the flight-design component's life. The new facility includes two test rigs that are performing creep testing of the SRG heater head pressure vessel test articles at design temperature and with wall stresses ranging from operating level to seven times that (see the following photograph).

  11. CVD diamond resistor as heater and temperature sensor

    Energy Technology Data Exchange (ETDEWEB)

    Yang, G.S.; Aslam, M. [Michigan State Univ., East Lansing, MI (United States)

    1995-12-31

    Heat generation and temperature control, essential for most heater applications, require different components in a conventional system. We achieve the heat generation and temperature measurement simultaneously by using a single diamond resistor. Chemical vapor deposited (CVD) p-type diamond resistors with different dimensions were fabricated on polycrystalline diamond or oxidized Si substrates using diamond film technology compatible with integrated circuit (IC) processing. The temperature response of the resistors was characterized in the temperature range of 25 - 500{degrees}C. Power densities in access of 600 watt/in{sup 2} were achieved.

  12. Integral finned heater and cooler for stirling engines

    Science.gov (United States)

    Corey, John A.

    1984-01-01

    A piston and cylinder for a Stirling engine and the like having top and bottom meshing or nesting finned conical surfaces to provide large surface areas in close proximity to the working gas for good thermal (addition and subtraction of heat) exchange to the working gas and elimination of the usual heater and cooler dead volume. The piston fins at the hot end of the cylinder are perforated to permit the gas to pass into the piston interior and through a regenerator contained therein.

  13. Simple Retrofit High-Efficiency Natural Gas Water Heater Field Test

    Energy Technology Data Exchange (ETDEWEB)

    Schoenbauer, Ben [NorthernSTAR, St. Paul, MN (United States)

    2017-03-01

    High-performance water heaters are typically more time consuming and costly to install in retrofit applications, making high performance water heaters difficult to justify economically. However, recent advancements in high performance water heaters have targeted the retrofit market, simplifying installations and reducing costs. Four high efficiency natural gas water heaters designed specifically for retrofit applications were installed in single-family homes along with detailed monitoring systems to characterize their savings potential, their installed efficiencies, and their ability to meet household demands. The water heaters tested for this project were designed to improve the cost-effectiveness and increase market penetration of high efficiency water heaters in the residential retrofit market. The retrofit high efficiency water heaters achieved their goal of reducing costs, maintaining savings potential and installed efficiency of other high efficiency water heaters, and meeting the necessary capacity in order to improve cost-effectiveness. However, the improvements were not sufficient to achieve simple paybacks of less than ten years for the incremental cost compared to a minimum efficiency heater. Significant changes would be necessary to reduce the simple payback to six years or less. Annual energy savings in the range of $200 would also reduce paybacks to less than six years. These energy savings would require either significantly higher fuel costs (greater than $1.50 per therm) or very high usage (around 120 gallons per day). For current incremental costs, the water heater efficiency would need to be similar to that of a heat pump water heater to deliver a six year payback.

  14. Simple Retrofit High-Efficiency Natural Gas Water Heater Field Test

    Energy Technology Data Exchange (ETDEWEB)

    Schoenbauer, Ben [NorthernSTAR, St. Paul, MN (United States)

    2017-03-28

    High performance water heaters are typically more time consuming and costly to install in retrofit applications, making high performance water heaters difficult to justify economically. However, recent advancements in high performance water heaters have targeted the retrofit market, simplifying installations and reducing costs. Four high efficiency natural gas water heaters designed specifically for retrofit applications were installed in single-family homes along with detailed monitoring systems to characterize their savings potential, their installed efficiencies, and their ability to meet household demands. The water heaters tested for this project were designed to improve the cost-effectiveness and increase market penetration of high efficiency water heaters in the residential retrofit market. The retrofit high efficiency water heaters achieved their goal of reducing costs, maintaining savings potential and installed efficiency of other high efficiency water heaters, and meeting the necessary capacity in order to improve cost-effectiveness. However, the improvements were not sufficient to achieve simple paybacks of less than ten years for the incremental cost compared to a minimum efficiency heater. Significant changes would be necessary to reduce the simple payback to six years or less. Annual energy savings in the range of $200 would also reduce paybacks to less than six years. These energy savings would require either significantly higher fuel costs (greater than $1.50 per therm) or very high usage (around 120 gallons per day). For current incremental costs, the water heater efficiency would need to be similar to that of a heat pump water heater to deliver a six year payback.

  15. PTC124 is an orally bioavailable compound that promotes suppression of the human CFTR-G542X nonsense allele in a CF mouse model

    Science.gov (United States)

    Du, Ming; Liu, Xiaoli; Welch, Ellen M.; Hirawat, Samit; Peltz, Stuart W.; Bedwell, David M.

    2008-01-01

    Nonsense mutations inactivate gene function and are the underlying cause of a large percentage of the individual cases of many genetic disorders. PTC124 is an orally bioavailable compound that promotes readthrough of premature translation termination codons, suggesting that it may have the potential to treat genetic diseases caused by nonsense mutations. Using a mouse model for cystic fibrosis (CF), we show that s.c. injection or oral administration of PTC124 to Cftr−/− mice expressing a human CFTR-G542X transgene suppressed the G542X nonsense mutation and restored a significant amount of human (h)CFTR protein and function. Translational readthrough of the premature stop codon was demonstrated in this mouse model in two ways. First, immunofluorescence staining showed that PTC124 treatment resulted in the appearance of hCFTR protein at the apical surface of intestinal glands in Cftr−/− hCFTR-G542X mice. In addition, functional assays demonstrated that PTC124 treatment restored 24–29% of the average cAMP-stimulated transepithelial chloride currents observed in wild-type mice. These results indicate that PTC124 can effectively suppress the hCFTR-G542X nonsense mutation in vivo. In light of its oral bioavailability, safety toxicology profile in animal studies, and efficacy with other nonsense alleles, PTC124 has the potential to be an important therapeutic agent for the treatment of inherited diseases caused by nonsense mutations. PMID:18272502

  16. Toward a rationale for the PTC124 (Ataluren) promoted readthrough of premature stop codons: a computational approach and GFP-reporter cell-based assay.

    Science.gov (United States)

    Lentini, Laura; Melfi, Raffaella; Di Leonardo, Aldo; Spinello, Angelo; Barone, Giampaolo; Pace, Andrea; Palumbo Piccionello, Antonio; Pibiri, Ivana

    2014-03-03

    The presence in the mRNA of premature stop codons (PTCs) results in protein truncation responsible for several inherited (genetic) diseases. A well-known example of these diseases is cystic fibrosis (CF), where approximately 10% (worldwide) of patients have nonsense mutations in the CF transmembrane regulator (CFTR) gene. PTC124 (3-(5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl)-benzoic acid), also known as Ataluren, is a small molecule that has been suggested to allow PTC readthrough even though its target has yet to be identified. In the lack of a general consensus about its mechanism of action, we experimentally tested the ability of PTC124 to promote the readthrough of premature termination codons by using a new reporter. The reporter vector was based on a plasmid harboring the H2B histone coding sequence fused in frame with the green fluorescent protein (GFP) cDNA, and a TGA stop codon was introduced in the H2B-GFP gene by site-directed mutagenesis. Additionally, an unprecedented computational study on the putative supramolecular interaction between PTC124 and an 11-codon (33-nucleotides) sequence corresponding to a CFTR mRNA fragment containing a central UGA nonsense mutation showed a specific interaction between PTC124 and the UGA codon. Altogether, the H2B-GFP-opal based assay and the molecular dynamics (MD) simulation support the hypothesis that PTC124 is able to promote the specific readthrough of internal TGA premature stop codons.

  17. [Dose-Response Dependences for Frequency of RET/PTC Gene Rearrangements in Papillary Thyroid Carcinoma after Irradiation. Simple Pooling Analysis of Molecular Epidemiological Data].

    Science.gov (United States)

    Koterov, A N; Ushenkova, L N; Biryukov, A P

    2016-01-01

    On the basis of all possible publications on the theme included in the previously formed base of sources on molecular epidemiology of RET/PTC rearrangements in thyroid papillary carcinoma a pooled analysis ("simple pooling data") on determination of the dose-effect dependences for RET/PTC frequency in radiogenic carcinomas of various irradiated groups was performed. (They are groups subjected to radiotherapeutic exposure, residents near the Chernobyl nuclear power plant (CNPP) and victims of nuclear bombing). The tendency to Pearson linear correlation (r = 0.746; p = 0.148) between the frequency of RET/PTC and the estimated dose on thyroid in the regions affected by the CNPP accident was revealed. But this tendency was recognized to be random owing to abnormally low values of the indicator for the most contaminated Gomel region. The method tentatively called "case-control" showed reliable differences in thyroid dose values for carcinomas with RET/PTC and without those. The versatility of changes was found: the lack of RET/PTC for radiotherapeutic impacts was associated with higher doses, whereas in case of the CNPP accident and for nuclear bombing victims it was the opposite. Probably, in the first case the "cellular cleaning" phenomenon after exposure to very high doses took place. Search of direct Pearson correlations between average/median thyroid doses on groups and RET/PTC frequency in carcinomas of these groups showed a high reliability for the dose-effect dependences- at the continuous dose scale (for RET/PTC in total and RET/PTC1 respectively: r = 0.830; p = 0.002 and r = 0.906; p = 0.0003); while there was no significant correlation received for RET/PTC3. When using the weighting least square regression analysis (proceeding from the number of carcinomas in samples), the specified regularities remained. Attempts to influence the strength of correlation by exception ofthe data of all the samples connected with the accident on the CNPP did not significantly

  18. High-performance, bare silver nanowire network transparent heaters.

    Science.gov (United States)

    Ergun, Orcun; Coskun, Sahin; Yusufoglu, Yusuf; Unalan, Husnu Emrah

    2016-11-04

    Silver nanowire (Ag NW) networks are one of the most promising candidates for the replacement of indium tin oxide (ITO) thin films in many different applications. Recently, Ag-NW-based transparent heaters (THs) showed excellent heating performance. In order to overcome the instability issues of Ag NW networks, researchers have offered different hybrid structures. However, these approaches not only require extra processing, but also decrease the optical performance of Ag NW networks. So, it is important to investigate and determine the thermal performance limits of bare-Ag-NW-network-based THs. Herein, we report on the effect of NW density, contact geometry, applied bias, flexing and incremental bias application on the TH performance of Ag NW networks. Ag-NW-network-based THs with a sheet resistance and percentage transmittance of 4.3 Ω sq(-1) and 83.3%, respectively, and a NW density of 1.6 NW μm(-2) reached a maximum temperature of 275 °C under incremental bias application (5 V maximum). With this performance, our results provide a different perspective on bare-Ag-NW-network-based transparent heaters.

  19. Asymmetric Pentagonal Metal Meshes for Flexible Transparent Electrodes and Heaters.

    Science.gov (United States)

    Lordan, Daniel; Burke, Micheal; Manning, Mary; Martin, Alfonso; Amann, Andreas; O'Connell, Dan; Murphy, Richard; Lyons, Colin; Quinn, Aidan J

    2017-02-08

    Metal meshes have emerged as an important class of flexible transparent electrodes. We report on the characteristics of a new class of asymmetric meshes, tiled using a recently discovered family of pentagons. Micron-scale meshes were fabricated on flexible polyethylene terephthalate substrates via optical lithography, metal evaporation (Ti 10 nm, Pt 50 nm), and lift-off. Three different designs were assessed, each with the same tessellation pattern and line width (5 μm), but with different sizes of the fundamental pentagonal unit. Good mechanical stability was observed for both tensile strain and compressive strain. After 1000 bending cycles, devices subjected to tensile strain showed fractional resistance increases in the range of 8-17%, while devices subjected to compressive strain showed fractional resistance increases in the range of 0-7%. The performance of the pentagonal metal mesh devices as visible transparent heaters via Joule heating was also assessed. Rapid response times (∼15 s) at low bias voltage (≤5 V) and good thermal resistance characteristics (213-258 °C cm(2)/W) were found using measured thermal imaging data. Deicing of an ice-bearing glass coupon on top of the transparent heater was also successfully demonstrated.

  20. Evaluation of Tube Wall Thickness of Feed Water Heater

    Science.gov (United States)

    Uchikura, Takahisa; Morisaki, Koichi; Hamada, Seiichi

    With regard to the high pressure (HP) feed water heater of thermal power plant at Tokyo Electric Power Company (TEPCO) sites, inspection of feed water (FW) tubes wall thickness are conducted whenever required such that frequent tube leak occurs. As a standard inspection methodology, FW heater is disassembled during planned outage, tube wall thickness is measured by the ultrasonic pulse techique (UT), then plugs are installed at the both ends of FW tube if its measured wall thickness is found below calculated threshold. However, the root causes of wall thinning of FW tube are various such as erosion and corrosion, based on wall thinning condition, the above threshold is not applied but utilizing the other technically well-grounded evaluation method is sometimes more rational. Therefore, TEPCO classified wall-thinning condition based on inspection data and established technically well-grounded and rational evaluation methodologies of FW tube wall thickness to suite each wall thinning condition. Moreover, with recent improvement of inspection technique, technology enabled faster, larger amount, and more accurate data acquisition, TEPCO has developed the systematized evaluation methodology that can transact data acquisition and evaluation simultaneously. This article introduces the logic of evaluation methods and examined algorithms to make them systematized.

  1. Eleana near-surface heater experiment final report

    Energy Technology Data Exchange (ETDEWEB)

    Lappin, A R; Thomas, R K; McVey, D F

    1981-04-01

    This report summarizes the results of a near-surface heater experiment operated at a depth of 23 m in argillite within the Eleana Formation on the Nevada Test Site (NTS). The test geometrically simulated emplacement of a single canister of High-Level Waste (HLW) and was operated at a power level of 2.5 kW for 21 days, followed by 3.8 kW to 250 days, when the power was turned off. Below 85 to 100{sup 0}C, there was good agreement between modeled and measured thermal results in the rock and in the emplacement hole, except for transient transport of water in the heater hole. Above 100{sup 0}C, modeled and measured thermal results increasingly diverged, indicating that the in-situ rock-mass thermal conductivity decreased as a result of dehydration more than expected on the basis of matrix properties. Correlation of thermomechanical modeling and field results suggests that this decrease was caused by strong coupling of thermal and mechanical behavior of the argillite at elevated temperatures. No hole-wall decrepitation was observed in the experiment; this fact and the codrrelation of modeled and measured results at lower temperatures indicate that there is no a priori reason to eliminate argillaceous rocks from further consideration as a host rock for nuclear wastes.

  2. A micro solar heater for portable energy generation

    Science.gov (United States)

    Zimmerman, Raúl; Morrison, Graham; The, Owen; Rosengarten, Gary

    2007-12-01

    This study presents a new concept that combines microtechnology with solar thermal energy to provide a free portable energy source. A water-methanol mixture flows through an array of parallel microchannels which are fabricated into a silicon matrix using conventional micro-fabrication techniques. A vacuum layer is interposed between the channels and the external surface to thermally insulate the channels from the ambient temperature. A selective coating is deposited on one of the vacuum walls to absorb the short wavelength incoming radiation and reduce the long wavelength radiation, hence reducing the heat losses. A geometry and material optimization is still being developed in order to obtain the highest possible efficiency for the micro-heater, while keeping a low pressure drop in the micro-channels. The methanol outlet temperature is predicted to be higher than 250°C. This temperature is required for hydrogen production in a methanol reforming micro-reactor. Therefore, it is envisaged that the micro-solar heater will supply the thermal energy needed for hydrogen generation, that can later be used as fuel for microfuel cells. Both technologies can be integrated in a portable device.

  3. 40 CFR 63.7491 - Are any boilers or process heaters not subject to this subpart?

    Science.gov (United States)

    2010-07-01

    ...., hazardous waste boilers). (e) A commercial and industrial solid waste incineration unit covered by 40 CFR... CATEGORIES (CONTINUED) National Emission Standards for Hazardous Air Pollutants for Industrial, Commercial... process heaters not subject to this subpart? The types of boilers and process heaters listed in paragraphs...

  4. 46 CFR 52.01-35 - Auxiliary, donkey, fired thermal fluid heater, and heating boilers.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 2 2010-10-01 2010-10-01 false Auxiliary, donkey, fired thermal fluid heater, and... requirements for miscellaneous boiler types, such as donkey, fired thermal fluid heater, heating boiler, etc... (CONTINUED) MARINE ENGINEERING POWER BOILERS General Requirements § 52.01-35 Auxiliary, donkey, fired...

  5. 76 FR 28662 - Industrial, Commercial, and Institutional Boilers and Process Heaters and Commercial and...

    Science.gov (United States)

    2011-05-18

    ... AGENCY 40 CFR Parts 60 and 63 RIN 2060-AQ25; 2060-AO12 Industrial, Commercial, and Institutional Boilers and Process Heaters and Commercial and Industrial Solid Waste Incineration Units AGENCY: Environmental... Major Sources: Industrial, Commercial, and Institutional Boilers and Process Heaters'' and ``Standards...

  6. Demonstration of a heat pump water heater. Volume 3. Design report

    Energy Technology Data Exchange (ETDEWEB)

    Sloane, B.D.; Krise, R.C.; Kent, D.D.

    1979-12-01

    Work performed during the pilot run manufacturing and laboratory testing stages of a heat pump water heater for residential installations is described. A general description of the heat pump water heater is provided, as are detailed discussions of individual components. Also included is a description of the pilot run manufacturing facility and experience, laboratory operations, and laboratory test data.

  7. Analysis of Large- Capacity Water Heaters in Electric Thermal Storage Programs

    Energy Technology Data Exchange (ETDEWEB)

    Cooke, Alan L. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Anderson, David M. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Winiarski, David W. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Carmichael, Robert T. [Cadeo Group, Washington D. C. (United States); Mayhorn, Ebony T. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Fisher, Andrew R. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2015-03-17

    This report documents a national impact analysis of large tank heat pump water heaters (HPWH) in electric thermal storage (ETS) programs and conveys the findings related to concerns raised by utilities regarding the ability of large-tank heat pump water heaters to provide electric thermal storage services.

  8. Tankless water heaters fill the bill at fast-food restaurants

    Energy Technology Data Exchange (ETDEWEB)

    1988-02-01

    This article explains why Kentucky Fried Chicken has installed a PH-24 water heater. The tankless water heater meets the restaurant's criteria for space spacing, flow rates, certification and availability, and money saving efficiency. This article describes the system and its advantages.

  9. 75 FR 21981 - Energy Conservation Program: Energy Conservation Standards for Residential Water Heaters, Direct...

    Science.gov (United States)

    2010-04-27

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY 10 CFR Part 430 RIN 1904-AA90 Energy Conservation Program: Energy Conservation Standards for Residential Water Heaters, Direct Heating Equipment, and Pool Heaters Correction In rule document 2010-7611 beginning...

  10. High voltage bus and auxiliary heater control system for an electric or hybrid vehicle

    Science.gov (United States)

    Murty, Balarama Vempaty

    2000-01-01

    A control system for an electric or hybrid electric vehicle includes a vehicle system controller and a control circuit having an electric immersion heater. The heater is electrically connected to the vehicle's high voltage bus and is thermally coupled to a coolant loop containing a heater core for the vehicle's climate control system. The system controller responds to cabin heat requests from the climate control system by generating a pulse width modulated signal that is used by the control circuit to operate the heater at a duty cycle appropriate for the amount of cabin heating requested. The control system also uses the heater to dissipate excess energy produced by an auxiliary power unit and to provide electric braking when regenerative braking is not desirable and manual braking is not necessary. The control system further utilizes the heater to provide a safe discharge of a bank of energy storage capacitors following disconnection of the battery or one of the high voltage connectors used to transmit high voltage operating power to the various vehicle systems. The control circuit includes a high voltage clamping circuit that monitors the voltage on the bus and operates the heater to clamp down the bus voltage when it exceeds a pre-selected maximum voltage. The control system can also be used to phase in operation of the heater when the bus voltage exceeds a lower threshold voltage and can be used to phase out the auxiliary power unit charging and regenerative braking when the battery becomes fully charged.

  11. Analysis of Uncertainties in Protection Heater Delay Time Measurements and Simulations in Nb$_{3}$Sn High-Field Accelerator Magnets

    CERN Document Server

    Salmi, Tiina; Marchevsky, Maxim; Bajas, Hugo; Felice, Helene; Stenvall, Antti

    2015-01-01

    The quench protection of superconducting high-field accelerator magnets is presently based on protection heaters, which are activated upon quench detection to accelerate the quench propagation within the winding. Estimations of the heater delay to initiate a normal zone in the coil are essential for the protection design. During the development of Nb3Sn magnets for the LHC luminosity upgrade, protection heater delays have been measured in several experiments, and a new computational tool CoHDA (Code for Heater Delay Analysis) has been developed for heater design. Several computational quench analyses suggest that the efficiency of the present heater technology is on the borderline of protecting the magnets. Quantifying the inevitable uncertainties related to the measured and simulated delays is therefore of pivotal importance. In this paper, we analyze the uncertainties in the heater delay measurements and simulations using data from five impregnated high-field Nb3Sn magnets with different heater geometries. ...

  12. ret/PTC activation is not associated with individual radiation dose estimates in a pilot study of neoplastic thyroid nodules arising in Russian children and adults exposed to Chernobyl fallout.

    Science.gov (United States)

    Tuttle, R Michael; Lukes, Yvonne; Onstad, Lynn; Lushnikov, Eugeni; Abrosimov, Alexander; Troshin, Vladislav; Tsyb, Anatoli; Davis, Scott; Kopecky, Kenneth J; Francis, Gary

    2008-08-01

    Ionizing radiation is the strongest risk factor known for the development of thyroid neoplasia. While previous studies have demonstrated a high prevalence of ret/papillary thyroid cancer (PTC) activation in cohorts of patients developing thyroid nodules after childhood exposure to ionizing radiation, no study has directly compared ret/PTC activation with individual estimates of radiation dose to the thyroid. This study combines individual thyroid dosimetry data with molecular analysis of surgically removed thyroid nodules in order to determine if ret/PTC activation in thyroid nodules is associated with increasing estimated radiation dose from Chernobyl. This pilot study included adults and children diagnosed with PTC (n = 76) and children diagnosed with follicular adenomas (n = 24) during May 1986 through December 1999, who were living in the Bryansk Oblast of the Russian Federation at the time of the Chernobyl accident, who had paraffin-embedded thyroid surgical samples available and for whom an individual dose to the thyroid could be estimated. The frequency of ret/PTC activation was determined using RT-PCR analysis. Individual radiation doses to the thyroid were estimated using a semiempirical model, and data were collected by detailed interview, primarily of the participant's mother. ret/PTC oncogene activation was detected in 23.8% (5/21) and 14.5% (8/55) of the childhood and adult PTC cases, respectively, and 8.3% (2/24) of the follicular adenoma cases. No statistically significant differences were noted in age at the time of exposure or diagnosis, gender, latency period, or estimated radiation dose between PTC patients with or without ret/PTC activation. Further, no significant dose-response relationship was detected among PTC patients with ret/PTC activation. Factors other than individual thyroid radiation doses may influence the development and subsequent detection of ret/PTC oncogene activation in radiation related PTC arising in the Bryansk Oblast of the

  13. Modulatory role of phospholipase D in the activation of signal transducer and activator of transcription (STAT-3 by thyroid oncogenic kinase RET/PTC

    Directory of Open Access Journals (Sweden)

    Kim Dong Wook

    2008-05-01

    Full Text Available Abstract Background RET/PTC (rearranged in transformation/papillary thyroid carcinomas gene rearrangements are the most frequent genetic alterations identified in papillary thyroid carcinoma. Although it has been established that RET/PTC kinase plays a crucial role in intracellular signaling pathways that regulate cellular transformation, growth, and proliferation in thyroid epithelial cells, the upstream signaling that leads to the activation of RET/PTC is largely unknown. Based on the observation of high levels of PLD expression in human papillary thyroid cancer tissues, we investigated whether PLD plays a role in the regulating the RET/PTC-induced STAT3 activation. Methods Cancer tissue samples were obtained from papillary thyroid cancer patients (n = 6. The expression level of PLD was examined using immunohistochemistry and western blotting. Direct interaction between RET/PTC and PLD was analyzed by co-immunoprecipitation assay. PLD activity was assessed by measuring the formation of [3H]phosphatidylbutanol, the product of PLD-mediated transphosphatidylation, in the presence of n-butanol. The transcriptional activity of STAT3 was assessed by m67 luciferase reporter assay. Results In human papillary thyroid cancer, the expression levels of PLD2 protein were higher than those in the corresponding paired normal tissues. PLD and RET/PTC could be co-immunoprecipitated from cells where each protein was over-expressed. In addition, the activation of PLD by pervanadate triggered phosphorylation of tyrosine 705 residue on STAT-3, and its phosphorylation was dramatically higher in TPC-1 cells (from papillary carcinoma that have an endogenous RET/PTC1 than in ARO cells (from anaplastic carcinoma without alteration of total STAT-3 expression. Moreover, the RET/PTC-mediated transcriptional activation of STAT-3 was synergistically increased by over-expression of PLD, whereas the PLD activity as a lipid hydrolyzing enzyme was not affected by RET/PTC

  14. High thermal performance of SnO2:F thin transparent heaters with scattered metal nanodots.

    Science.gov (United States)

    Hudaya, Chairul; Jeon, Bup Ju; Lee, Joong Kee

    2015-01-14

    Facile production and novel transparent heaters consisting of fluorine-doped tin oxide (SnO2:F or FTO) thin films covered with three different scattered metal nanodots (Cr-nd, NiCr-nd and Ni-nd) prepared by plasma-enhanced sputtering system and electron cyclotron resonance-metal organic chemical vapor deposition are investigated. The heaters exhibit excellent optical transmittances of over 85% and superior saturated temperatures of more than 80 °C when a relatively low 12 V DC is supplied. The scattered metal nanodots FTO heaters successfully improve the specific power of bare FTO heater by 21, 15, and 12% for NiCr-nd FTO, Cr-nd FTO, and Ni-nd FTO, respectively. These results reveal that the FTO transparent heaters with scattered metal nanodots are the suitable heating materials that can be applied for various functional devices.

  15. Evaluation and certification of heater assemblies developed for thermal vacuum acceptance testing

    Science.gov (United States)

    Allen, J. E.

    1986-01-01

    Preparation of Rockwell International's Thermal Vacuum Chamber for acceptance testing of a mass produced satellite required the development of unique quartz lamp and hot wire heater assemblies. Testing performed on the basic elements of these heaters is described, as is the final testing done to certify that the heater assemblies meet the thermal requirements for acceptance testing. The methods and procedures of thermal mapping used during the development and final certification of these heater assemblies are presented. The absence of a definitive standard for determining flux distribution and heating boundaries for heaters of this type required the development of a test plan incorporating several thermal mapping techniques. These techniques include the development of heat flux using a multiple calorimeter array for both vacuum and ambient test conditions, and a photographic method for detecting heating boundaries. The test plan and thermal mapping techniques are discussed.

  16. Mutagenicity of organic emissions from unvented kerosene heaters in a chamber study.

    Science.gov (United States)

    Mumford, J L; Lewtas, J; Williams, K; Tucker, W G; Traynor, G W

    1992-06-01

    A study was conducted to assess the mutagenicity of semivolatile organics and particle-bound organics emitted from unvented kerosene space heaters. The units tested included a well-tuned radiant heater and a maltuned convective heater. The tests were conducted in a 27-m3 chamber with a prescribed on/off heater usage pattern. The organic emissions were collected on Teflon-coated glass filters backed by XAD-2 resin. The dichloromethane-extractable organics from both the filters and the XAD were analyzed for nitropolycyclic hydrocarbons using gas chromatography/mass spectrometry, and were bioassayed for mutagenicity in microsuspension assays using Salmonella typhimurium strains TA98 with and without S9 and TA98NR (a nitroreductase-deficient strain) without S9. The results showed that both the semivolatile and particle-bound organics emitted from the kerosene heaters were mutagenic, and the presence of nitropolycyclic hydrocarbons in these organic emissions substantiated these findings.

  17. Protection Heater Design Validation for the LARP Magnets Using Thermal Imaging

    CERN Document Server

    Marchevsky, M; Cheng, D W; Felice, H; Sabbi, G; Salmi, T; Stenvall, A; Chlachidze, G; Ambrosio, G; Ferracin, P; Izquierdo Bermudez, S; Perez, J C; Todesco, E

    2016-01-01

    Protection heaters are essential elements of a quench protection scheme for high-field accelerator magnets. Various heater designs fabricated by LARP and CERN have been already tested in the LARP high-field quadrupole HQ and presently being built into the coils of the high-field quadrupole MQXF. In order to compare the heat flow characteristics and thermal diffusion timescales of different heater designs, we powered heaters of two different geometries in ambient conditions and imaged the resulting thermal distributions using a high-sensitivity thermal video camera. We observed a peculiar spatial periodicity in the temperature distribution maps potentially linked to the structure of the underlying cable. Two-dimensional numerical simulation of heat diffusion and spatial heat distribution have been conducted, and the results of simulation and experiment have been compared. Imaging revealed hot spots due to a current concentration around high curvature points of heater strip of varying cross sections and visuali...

  18. Application of the Peroxotitanium Complex (PTC) for Flexible Dye Sensitized Solar Cells (DSSC)%过氧化钛配合物(PTC)体系在柔性染料敏化太阳能电池中的应用

    Institute of Scientific and Technical Information of China (English)

    张阳; 曾庆慧; 只金芳

    2009-01-01

    The anatase TiO_2 sol prepared from Peroxotitanium Complex (PTC) at low temperature was used as the additive for photo-anode of flexible dye sensitized solar cells (DSSC). It is found that the photoelectric performance of DSSC was obviously increased by 50 % with the addition of TiO_2 sol. Furthermore, we investigated the effects of the sol content and reaction time on the pho-toelectric performance. It is proved that there is an optimal addition value for the DSSC application. When the content (volume) of PTC sol is 10% and refluxing time reaches to 9 h, the best photo-electric performance is obtained.%本文利用水性过氧化钛配合物(peoxotitanium complex:PTC)前驱体可低温合成锐钛矿TiO_2溶胶的特性,将其用作柔性染料敏化太阳能电池(DSSC)中的光阳极材料的成膜助剂.研究发现:加入基于PTC制得的TiO_2溶胶可以明显提高DSSC的光电转换性能,在制备DSSC的浆料中加入10%(体积分数)的基于PTC制得的TiO_2溶胶后,电池的光电效率可以提升50%.我们进一步研究了光电转换效率的影响因素,结果表明,溶胶的加入量和反应时间均有一最佳值,当基于PTC的TiO_2溶胶添加量为10%,反应时间为9 h,所得到电池的光电性能最好.

  19. Proceedings of a workshop on the utilization of coal fuels in process heaters

    Energy Technology Data Exchange (ETDEWEB)

    1979-01-01

    Almost 5% of the nation's energy consumption takes place in tubular process heaters. Currently, these units are gas- and, to a lesser extent, oil-fired. Process heaters provide energy for refining petroleum and the manufacture of numerous chemicals and petrochemicals. Since the current state-of-the-art, using waste heat recovery and forced draft burners, can achieve thermal efficiencies of about 90%, it is unlikely that current process heat and fuel requirements will be dramatically reduced by process modifications and/or conservation measures. Hence, if this sizeable, inexorable drain on our fluid petroleum reserves is to be halted, it seems reasonable to consider the utilization of coal and/or coal-based fuels to fire process heaters. In order to assess the feasibility and potential for a coal-based process heater industry, Brookhaven National Laboratory (BNL) organized a workshop to define and explore the various problems that must be solved in order to burn coal in process heaters. A primary aim of the workshop was to consider the design methodology for process heaters when firing coal and compare it to those for gas and oil firing. The overall conclusions were: that retrofitting present process heaters to coal fuel was impractical; that it would be difficult to fit larger heaters designed to burn coal into present refineries; that there would be difficulties with process heaters burning coal; and that a better approach would be one large utility coal heater with a circulating heat transfer medium. Seven papers have been entered individually into EDB and ERA. (LTN)

  20. Determination and Analysis on Taste-Blindness Gene Frequency to Phenylthiocarbamide(PTC)%苯硫脲(PTC)味盲基因频率的测定与分析

    Institute of Scientific and Technical Information of China (English)

    赵淑娟; 庞有志; 杨又兵; 郭晓红

    2005-01-01

    目的测定河南省汉族青少年苯硫脲(PTC)味盲基因频率.方法采用阈值法测定219名汉族青少年对PTC的尝味敏感性.结果味盲率为8.22%,味盲基因频率为0.2867,尝味基因频率为0.7133.结论尝味能力与民族、地理位置以及某些疾病有关.

  1. 10 CFR 431.106 - Uniform test method for the measurement of energy efficiency of commercial water heaters and hot...

    Science.gov (United States)

    2010-01-01

    ... Instantaneous Water Heaters and Hot Water Supply Boilers* Thermal Efficiency ANSI Z21.10.3-1998, § 2.9** A. For... Instantaneous Water Heaters and Hot Water Supply Boilers* Thermal Efficiency ANSI Z21.10.3-1998, § 2.9** (2) Oil...) Assume that the thermal efficiency (Et) of electric water heaters with immersed heating elements is...

  2. Heat Pump Water Heater Durabliltiy Testing - Phase II

    Energy Technology Data Exchange (ETDEWEB)

    Baxter, VAND.

    2004-05-29

    Ten heat pump water heaters (HPWH) were placed in an environmentally controlled test facility and run through a durability test program of approximately 7300 duty cycles (actual cycles accumulated ranged from 6640 to 8324 for the ten units). Five of the units were upgraded integral types (HPWH mounted on storage tank, no pump) from the same manufacturer as those tested in our first durability program in 2001 (Baxter and Linkous, 2002). The other five were ''add-on'' type units (HPWH with circulation pump plumbed to a separate storage tank) from another manufacturer. This durability test was designed to represent approximately 7-10 years of normal operation to meet the hot water needs of a residence. The integral units operated without incident apart from two control board failures. Both of these were caused by inadvertent exposure to very hot and humid (>135 F dry bulb and >120 F dew point) conditions that occurred due to a test loop failure. It is not likely that any residential water heater would be installed where such conditions were expected so these failures are not considered a long-term reliability concern. Two of the integral HPWHs featured a condensate management system (CMS) option that effectively eliminated any need for an evaporator condensate drain, but imposed significant efficiency penalties when operating in high humidity ambient conditions. The add-on units experienced no operational failures (breakdowns with loss of hot water production) during the course of the testing. However, their control systems exhibited some performance degradation under the high temperature, high humidity test conditions--HPWHs would shut off with tank water temperatures 15-20 F lower than when operating under moderate ambient conditions. One unit developed a refrigerant leak during the test program and lost about 50% of its charge resulting in reduced efficiency. Efficiency measurements on all the integral units and four of the add-on units showed

  3. Prediction of heater power distribution in radiative cylindrical furnaces

    Energy Technology Data Exchange (ETDEWEB)

    Ravichandran, M.; Dilber, I.; Torok, D.

    1999-07-01

    In the design of long radiative cylindrical furnaces, it is important to control the temperature variation along the furnace walls and consequently the temperature distribution in the processed material by selectively adjusting the power input to heater rods located circumferentially around the furnace walls. The heaters are grouped in zones located at different axial locations. By adjusting the power to each zone a specified temperature distribution along the furnace can be attained. The radiative interchange between different axial zones of the furnace affects the temperature distribution; this interchange is also impacted by the shadowing caused by the presence of the load, i.e. the processed material. A desired temperature distribution can only be achieved by selectively changing the power input to the heaters. For an a priori assessment of the commercial viability of using process friendly temperature distributions, it is necessary to determine: (a) the maximum power demand from each zone; (b) if active cooling is inevitable and (c) the bounds on temperature distribution that can be achieved without active cooling. It is therefore extremely useful to be able to predict the input power distribution for achieving desired furnace temperature profiles. For a given power input, the temperature distribution inside the furnace could be obtained by using a general purpose Computational Fluid Dynamics (CFD) software, such as FIDAP. A new methodology is developed within the framework of FIDAP software to eliminate the manual trial and error method. The method is based on obtaining the sensitivity of the temperature at the desired locations of the furnace as a function of the power input to the heating elements. Using these sensitivity coefficients, an iterative scheme is designed to adjust the boundary conditions (power to the heating elements in this case) based on the discrepancy of the solution temperatures from the desired temperature distribution. For each of these

  4. Analysis of thermal stresses in horizontal delivery water heaters

    Science.gov (United States)

    Bilan, A. V.; Plotnikov, P. N.

    2016-11-01

    Analysis of thermal stresses in tubes and a compensator, taking into account water heating in each heater bunch and temperature at which its mounting is implemented, and of stresses on pressure is presented. The 3D-model of the horizontal delivery water heater of PSG-4900-0.3-1.14 type is used. The tube plate is represented as the 3D-body with 6863 holes with offset center of the perforated area, the steam space shell is represented as a cylindrical casing, the bottoms of water chambers are considered as elliptical casings, the four-lens compensator is represented in the form of toroidal casings, and the tubes are considered as beams operating in tensile-compression and bending in two planes. Calculations were carried out for different temperatures of superheated steam and a steam space shell, respectively, as well as designs with compensator and without it. Various temperature values of the tubes on the passes were calculated and set. The studies were carried out taking into account nonaxis-symmetrical spacing the tube plate and compensator deformation. The calculation results of tensile-compression stresses in the tubes are presented. Furthermore, the central tubes experience compressive stresses, whose maximal values take place on the border between the tubes of the fourth and of the first passes. For its decrease, it is recommended to increase the distance between the tubes of these passes. The tension stresses in the peripheral tubes are the maximal stresses. To reduce the stresses and, therefore, increase service life of the delivery water heater at using wet or superheated (not more than by 30-50°C) steam in it (the larger value refers to the brass tubes and the water pressure of 1.6-2.5 MPa), it is necessary to recommend the noncompensatory design at using the steam superheated by more than 30-50°C (at Ural Turbine Works, it is the turbines of T-250/300-23.5 and T-113/145-12.4 types with intermediate superheating) and to recommend the installation of the

  5. 46 CFR 177.500 - Means of escape.

    Science.gov (United States)

    2010-10-01

    ...) There is no stove, heater, or other source of fire in the space; (3) The means of escape is located as... this section, each space accessible to passengers or used by the crew on a regular basis, must have at... escape must be widely separated and, if possible, at opposite ends or sides of the space to minimize the...

  6. Iodine regulates G2/M progression induced by CCL21/CCR7 interaction in primary cultures of papillary thyroid cancer cells with RET/PTC expression.

    Science.gov (United States)

    Zhang, You-Yuan; Liu, Ze-Bing; Ye, Xuan-Guang; Ren, Wei-Min

    2016-10-01

    Treatment with high iodine concentrations can delay oncogenic activation effects, reduce cell growth and return thyroid-specific gene and protein expression levels to normal. During rearranged during transfection (RET)/papillary thyroid carcinoma (PTC) 3 activation, excess iodine can act as a protective agent in thyroid follicular cells. The chemokine receptor CCR7 serves a critical role in lymphocyte trafficking into and within lymph nodes, the preferential metastatic site for PTC. However, the potential associations between chemokine (C‑C motif) ligand 21 (CCL21)/C‑C chemokine receptor type 7 (CCR7) interaction and iodine concentrations in primary cultures of PTC with RET/PTC expression remain unclear. Proliferation assays of primary cultures of PTC cells with RET/PTC1 and RET/PTC3 expression indicated that CCR7 activation by its specific ligand, CCL21, was associated with significantly increased cell proliferation. Flow cytometry data indicated that CCL21/CCR7 interaction significantly increased the fraction of cells in the G2/M phase of the cell cycle. Western blotting indicated that CCL21/CCR7 interaction significantly upregulated cyclin A, cyclin B1 and cyclin‑dependent kinase 1 (CDK1) expression. Western blotting determined that CCL21/CCR7 interaction significantly enhanced the levels of phosphorylated extracellular signal‑regulated kinase (P‑ERK). Co-immunoprecipitation confirmed that there was interaction between P‑ERK and cyclin A, cyclin B1 or CDK1, particularly in the presence of CCL21. Sodium iodide (NaI, 10-5 M) significantly abolished the effects of exogenous CCL21. These results suggest that CCL21/CCR7 interaction contributes to G2/M progression of RET/PTC‑expressing cells via the ERK pathway in association with 10‑5 M NaI.

  7. Nanostructured electrocatalyst for fuel cells : silica templated synthesis of Pt/C composites.

    Energy Technology Data Exchange (ETDEWEB)

    Stechel, Ellen Beth; Switzer, Elise E.; Fujimoto, Cy H.; Atanassov, Plamen Borissov; Cornelius, Christopher James; Hibbs, Michael R.

    2007-09-01

    Platinum-based electrocatalysts are currently required for state-of-the-art fuel cells and represent a significant portion of the overall fuel cell cost. If fuel cell technology is to become competitive with other energy conversion technologies, improve the utilization of precious metal catalysts is essential. A primary focus of this work is on creating enhanced nanostructured materials which improve precious-metal utilization. The goal is to engineer superior electrocatalytic materials through the synthesis, development and investigation of novel templated open frame structures synthesized in an aerosol-based approach. Bulk templating methods for both Pt/C and Pt-Ru composites are evaluated in this study and are found to be limited due to the fact that the nanostructure is not maintained throughout the entire sample. Therefore, an accurate examination of structural effects was previously impossible. An aerosol-based templating method of synthesizing nanostructured Pt-Ru electrocatalysts has been developed wherein the effects of structure can be related to electrocatalytic performance. The aerosol-based templating method developed in this work is extremely versatile as it can be conveniently modified to synthesize alternative materials for other systems. The synthesis method was able to be extended to nanostructured Pt-Sn for ethanol oxidation in alkaline media. Nanostructured Pt-Sn electrocatalysts were evaluated in a unique approach tailored to electrocatalytic studies in alkaline media. At low temperatures, nanostructured Pt-Sn electrocatalysts were found to have significantly higher ethanol oxidation activity than a comparable nanostructured Pt catalyst. At higher temperatures, the oxygen-containing species contribution likely provided by Sn is insignificant due to a more oxidized Pt surface. The importance of the surface coverage of oxygen-containing species in the reaction mechanism is established in these studies. The investigations in this work present

  8. Direct Determination of the Ionization Energies of PtC, PtO, and PtO2 with VUVRadiation

    Energy Technology Data Exchange (ETDEWEB)

    Citir, Murat; Metz, Ricardo B.; Belau, Leonid; Ahmed, Musahid

    2008-07-21

    Photoionization efficiency curves were measured for gas-phase PtC, PtO, and PtO2 using tunable vacuum ultraviolet (VUV) radiation at the Advanced Light Source. The molecules were prepared by laser ablation of a platinum tube, followed by reaction with CH4 or N2O and supersonic expansion. These measurements providethe first directly measured ionization energy for PtC, IE(PtC) = 9.45 +- 0.05 eV. The direct measurement also gives greatly improved ionization energies for the platinum oxides, IE(PtO) = 10.0 +- 0.1 eV and IE(PtO2) = 11.35 +- 0.05 eV. The ionization energy connects the dissociation energies of the neutral and cation, leading to greatly improved 0 K bond dissociation energies for the neutrals: D0(Pt-C) = 5.95 +- 0.07 eV, D0(Pt-O)= 4.30 +- 0.12 eV, and D0(OPt-O) = 4.41 +- 0.13 eV, as well as enthalpies of formation for the gas-phase molecules Delta H0 f,0(PtC(g)) = 701 +- 7 kJ/mol, Delta H0f,0(PtO(g)) = 396 +- 12 kJ/mol, and Delta H0f,0(PtO2(g)) = 218 +- 11 kJ/mol. Much of the error in previous Knudsen cell measurements of platinum oxide bond dissociation energies is due to the use of thermodynamic second law extrapolations. Third law values calculated using statistical mechanical thermodynamic functions are in much better agreement with values obtained from ionization energies and ion energetics. These experiments demonstrate that laser ablation production with direct VUV ionization measurements is a versatile tool to measure ionization energies and bond dissociation energies for catalytically interesting species such as metal oxides and carbides.

  9. Papillary thyroid carcinoma (PTC) in Lynch syndrome: Report of two cases and discussion on Lynch syndrome behaviour and genetics.

    Science.gov (United States)

    Pelizzo, M R; Pennelli, G; Zane, M; Galuppini, F; Colletti, P M; Merante Boschin, I; Rubello, D

    2015-08-01

    We present here two cases of papillary thyroid carcinoma (PTC) in patients affected by Lynch syndrome (LS). The first case is a 47-year-old woman with typical hereditary non-polyposis colorectal cancer (HNPCC) syndrome, reported with endometrial and ovarian carcinoma at age 43, and colon cancer at age 45. The patient underwent total thyroidectomy and central node dissection in 2007, at 47years old, with a histological diagnosis of PTC (T1aN1a). Molecular genetics showed a germ-line mutation of the MLH1 gene, 1858 G>T(E620X), with substitution of glycine with a stop codon at position 620. This mutation has pathogenetic significance and was considered responsible for the various tumours of the HNPCC spectrum. In particular, in the same kindred, spanning 5 generations, there were 5 members with colorectal cancer, 4 with endometrial cancer, 3 with gastric and 2 with breast cancer. The second case is a 34-year-old man with typical HNPCC syndrome with colonic resection for colon cancer at age 21. The patient underwent total thyroidectomy with central and lateral node dissection in 2010, at age 34, with a histological diagnosis of PTC with nodal metastases (pT4N1b). Molecular genetic analysis showed a germ-line mutation of the MSH2 gene (thymine insertion at position 907). This mutation had pathogenetic significance and was considered responsible for HNPCC development. Two similar cases have been reported: a 39-year-old woman, and a 44-year-old woman, affected by HNPCC syndrome, with anaplastic thyroid carcinoma and undifferentiated thyroid carcinoma, respectively. We reviewed the Lynch syndrome literature on the history, genetics and expanding tumour spectrum of this condition. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

  10. Controlled cellular fusion using optically trapped plasmonic nano-heaters

    Science.gov (United States)

    Bahadori, Azra; Lund, Andreas R.; Semsey, Szabolcs; Oddershede, Lene B.; Bendix, Poul M.

    2016-09-01

    Optically trapped plasmonic nano-heaters are used to mediate efficient and controlled fusion of biological membranes. The fusion method is demonstrated by optically trapping plasmonic nanoparticles located in between vesicle membranes leading to rapid lipid and content mixing. As an interesting application we show how direct control over fusion can be used for studying diffusion of peripheral membrane proteins and their interactions with membranes and for studying protein reactions. Membrane proteins encapsulated in an inert vesicle can be transferred to a vesicle composed of negative lipids by optically induced fusion. Mixing of the two membranes results in a fused vesicle with a high affinity for the protein and we observe immediate membrane tubulation due to the activity of the protein. Fusion of distinct membrane compartments also has applications in small scale chemistry for realizing pico-liter reactions and offers many exciting applications within biology which are discussed here.

  11. Thermoacoustic Stirling Heat Pump Working as a Heater

    Science.gov (United States)

    Bassem, Mohamed Mehdi; Ueda, Yuki; Akisawa, Atsushi

    2011-10-01

    A prototype thermoacoustic heat pump working as a heater was demonstrated. The heat pump was composed of an acoustic driver, a branched tube, and a looped tube containing a regenerator; the looped tube was connected to the acoustic driver via the branched tube, and the regenerator consisted of many narrow flow channels. The measurement results of the acoustic impedance inside the looped tube indicated that the energy conversion of the acoustic power flow into the acoustic heat flow in the regenerator occurred through the inherently efficient Stirling cycle. Moreover, the heat pump generated a hot temperature of 370 °C, corresponding to a temperature lift along the regenerator of 340 °C.

  12. THE HEAT AND FLUID FLOW ANALYSIS FOR WATER HEATER

    Directory of Open Access Journals (Sweden)

    Chien-Nan Lin

    2011-01-01

    Full Text Available In this paper, the heat transfer and fluid flow are studied for the water heater of RV cars, in which the hot water is heated by the combustion energy of liquefied petroleum gases. Three types of combustion tubes are performed in this investigation, which are circular tube, elliptic tube and elliptic tube with screwed wire inserted. The heat transfer performances of numerical simulation results are compared with those of the experimental works; they are in good trend agreement. The elliptic combustion tube performs better than the circular one, which indicates the average 7% energy saving for the elliptic combustion tube and 12% energy saving for the elliptic combustion tube with screwed wire under static heating.

  13. Results of MPBX studies at the single heater test

    Energy Technology Data Exchange (ETDEWEB)

    Blair, S. C.,LLNL

    1997-10-01

    We have developed an extensometer for measurement of distance and displacements in a geologic repository for high-level nuclear waste. This is an optical extensometer that measures distance using a modulated laser beam. In this design, reflecting targets are placed at desired measurement locations, and distance between each target and an optical head are measured repeatedly using the modulated laser beam. Moreover, all electronic and moving parts are located outside of the hostile or difficult environment as the optical head is connected to the laser, switching and signal analysis hardware using optical fibers. A reference beam is utilized to provide direct correction of system behavior. `Be system also - utilizes movable reflective anchors that can be repositioned if desired. We have installed the system in the Single Heater Test being conducted in Alcove 5 of the Exploratory Studies Facility at Yucca Mountain, and report preliminary results.

  14. Thin Film Heater for Removable Volatile Protecting Coatings

    Directory of Open Access Journals (Sweden)

    Abid Karim

    2013-01-01

    Full Text Available Freshly coated aluminum mirrors have excellent reflectivity at far ultraviolet wavelengths. However, reflectivity rapidly degrades when the mirror surfaces are exposed to atmosphere. In order to avoid this problem, freshly coated aluminum surface can be protected by over-coating of a removable volatile protecting coating. This protecting coating can be re-evaporated by controlled heating or by some other methods when required. This type of removable coating has immediate application in UV space astronomy. The purpose of this paper is to demonstrate the feasibility of re-evaporation of removable volatile Zn protecting coating using a NiCr thin film heater without affecting the reflection properties of Al mirror surfaces.

  15. Modelling of Closed Loop Class E Inverter Based Induction Heater

    Directory of Open Access Journals (Sweden)

    S. Arumugam

    2011-01-01

    Full Text Available This study presents simulation of class E inverter based induction heater system using simulink. DC is converted into high frequency AC using class E inverter. This high frequency AC is used for induction heating. Closed loop systems are modeled and they are simulated using Mat lab Simulink.The results of closed loop systems are presented. The proposed amplifier with two series-parallel resonant load networks will allow sinusoidal output voltage to be achieved by associating with the positive and negative quasi-sinusoidal waveforms. The complementarily activated configuration will provide continuous high-ripple-frequency inputcurrent waveforms; this approach significantly reduces electromagnetic interference and requires very little filtering. With the symmetry of the push-pull Class-E Circuit, there is the additional benefit that the even harmonics are suppressed at the load, and thus there are fewer harmonic distortions.

  16. Constant delivery temperature solar water heater - an integrated approach

    Energy Technology Data Exchange (ETDEWEB)

    Kumar, S. [C.A.S. Indian Institute of Technology, New Delhi (India); Kumar, N. [D.C.E. Muzaffarpur Institute of Technology, Bihar (India)

    1997-05-01

    An integrated model of a constant delivery temperature solar water heat-cum-active regenerative distillation system has been developed. The water used for the regenerative effect in the distiller of the proposed system is subsequently fed to the basin-cum-storage tank of the still through the heat exchanger (connected to the collector). The model varies the water mass flow rate in order to maintain a constant outlet temperature. With minor modifications in the solar water heater, the extra energy stored in the water mass due to non-utilization of capacity and/or non-linear utilization of capacity can be efficiently utilized for distillation purposes. In this process, the latent heat of vaporization is used for preheating the inlet water supply to the heat exchanger. The effect of insulation on maintaining the hot water temperature and distillate output is also presented. (Author)

  17. Investigations on CERN PSB Beam Dynamics with Strong Direct Space Charge Effects Using the PTC-Orbit Code

    CERN Document Server

    Forte, V; Carli, C; Martini, M; Metral, E; Mikulec, B; Schmidt, F; Molodozhentsev, A

    2013-01-01

    The CERN PS Booster (PSB) has the largest space charge tune spread in the LHC injector chain. As part of the LHC Injectors Upgrade (LIU) project, the machine will be upgraded. Space charge and resonances are serious is- sues for the good quality of the beam at injection energy. Consequently simulations are needed to track the beam in the machine taking into account space charge effects: PTC-ORBIT has been used as tracking code. This paper presents simulation results that are compared with mea-surements for machine performances evaluation and code- benchmarking purposes.

  18. Technique of optimization of minimum temperature driving forces in the heaters of regeneration system of a steam turbine unit

    Science.gov (United States)

    Shamarokov, A. S.; Zorin, V. M.; Dai, Fam Kuang

    2016-03-01

    At the current stage of development of nuclear power engineering, high demands on nuclear power plants (NPP), including on their economy, are made. In these conditions, improving the quality of NPP means, in particular, the need to reasonably choose the values of numerous managed parameters of technological (heat) scheme. Furthermore, the chosen values should correspond to the economic conditions of NPP operation, which are postponed usually a considerable time interval from the point of time of parameters' choice. The article presents the technique of optimization of controlled parameters of the heat circuit of a steam turbine plant for the future. Its particularity is to obtain the results depending on a complex parameter combining the external economic and operating parameters that are relatively stable under the changing economic environment. The article presents the results of optimization according to this technique of the minimum temperature driving forces in the surface heaters of the heat regeneration system of the steam turbine plant of a K-1200-6.8/50 type. For optimization, the collector-screen heaters of high and low pressure developed at the OAO All-Russia Research and Design Institute of Nuclear Power Machine Building, which, in the authors' opinion, have the certain advantages over other types of heaters, were chosen. The optimality criterion in the task was the change in annual reduced costs for NPP compared to the version accepted as the baseline one. The influence on the decision of the task of independent variables that are not included in the complex parameter was analyzed. An optimization task was decided using the alternating-variable descent method. The obtained values of minimum temperature driving forces can guide the design of new nuclear plants with a heat circuit, similar to that accepted in the considered task.

  19. Three-Dimensional Printable High-Temperature and High-Rate Heaters.

    Science.gov (United States)

    Yao, Yonggang; Fu, Kun Kelvin; Yan, Chaoyi; Dai, Jiaqi; Chen, Yanan; Wang, Yibo; Zhang, Bilun; Hitz, Emily; Hu, Liangbing

    2016-05-24

    High temperature heaters are ubiquitously used in materials synthesis and device processing. In this work, we developed three-dimensional (3D) printed reduced graphene oxide (RGO)-based heaters to function as high-performance thermal supply with high temperature and ultrafast heating rate. Compared with other heating sources, such as furnace, laser, and infrared radiation, the 3D printed heaters demonstrated in this work have the following distinct advantages: (1) the RGO based heater can operate at high temperature up to 3000 K because of using the high temperature-sustainable carbon material; (2) the heater temperature can be ramped up and down with extremely fast rates, up to ∼20 000 K/second; (3) heaters with different shapes can be directly printed with small sizes and onto different substrates to enable heating anywhere. The 3D printable RGO heaters can be applied to a wide range of nanomanufacturing when precise temperature control in time, placement, and the ramping rate are important.

  20. Thermal response of transparent silver nanowire/PEDOT:PSS film heaters.

    Science.gov (United States)

    Ji, Shulin; He, Weiwei; Wang, Ke; Ran, Yunxia; Ye, Changhui

    2014-12-10

    Thermal response behavior of transparent silver nanowire/PEDOT:PSS film heaters are intensively studied for manipulating heating temperature, response time, and power consumption. Influences of substrate heat capacity, heat transfer coefficient between air and heater, sheet resistance and dimension of Ag nanowire film, on the thermal response are investigated from thermodynamic analysis. Suggestion is given for practical applications that if other parameters are fixed, Ag nanowire coverage can be utilized as an effective parameter to adjust the thermal response. The heat transfer coefficient plays opposite roles on thermal response speed and achievable steady temperature. A value of ≈32 W m(-2) K(-1) is obtained from transient process analysis after correcting it by considering heater resistance variation during heating tests. Guidance of designing heaters with a given response time is provided by forming Ag nanowire film with a suitable sheet resistance on substrate of appropriate material and a certain thickness. Thermal response tests of designed Ag heaters are performed to show higher heating temperature, shorter response time, and lower power consumption (179 °C cm(2) W(-1)) than ITO/FTO heaters, as well as homogeneous temperature distribution and stability for repeated use. Potential applications of the Ag heaters in window defogging, sensing and thermochromism are manifested.

  1. Three-dimensional temperature field in a line-heater embedded by a spiral electric resistor

    Energy Technology Data Exchange (ETDEWEB)

    Hsiao, S.Y.; Wei, P.S.; Wang, Z.P. [Department of Mechanical and Electro-Mechanical Engineering, National Sun Yat-Sen University, 70, Lien-hai Road, Kaohsiung 804, Taiwan (China)

    2006-06-15

    In this study, three-dimensional temperature fields induced by AC and DC through a spiral electric resistor in a line-heater are numerically investigated. Electric heaters have been widely found, for example, in houses as dryers, stoves, and water heaters, and in industrial and research institutions as elements of equipments. The line-heater in the present model is realistically considered to have multiple regions composed of a spiral electric resistor, electrically insulated region, covering outer layer, and two terminal pins with distinct thermal and electrical properties. Solving unsteady three-dimensional heat conduction equations in distinct regions, the surface temperatures predicted as a function of time in this model are confirmed by the measured data. The calculated results quantitatively show that high surface temperatures of the heater can be reached by increasing dimensionless joule heat parameter, radius of the spiral electric resistor or pins, thermal diffusivity of the insulation region, and decreasing Biot number and radius of insulation region. The effects of the pins on surface temperature are also studied. Aside from showing that DC produces higher temperature than AC, the results indicate that the effects of current frequency on temperature fields are insignificant. The findings can be generalized to a curved heater, because any local location can be considered as a small line-segment. The present work provides general and quantitative data valuable for designing an efficient heater/furnace. [Author].

  2. PTC725, an NS4B-Targeting Compound, Inhibits a Hepatitis C Virus Genotype 3 Replicon, as Predicted by Genome Sequence Analysis and Determined Experimentally

    Science.gov (United States)

    Graci, Jason D.; Jung, Stephen P.; Pichardo, John; Tong, Xiao; Gu, Zhengxian

    2016-01-01

    PTC725 is a small molecule NS4B-targeting inhibitor of hepatitis C virus (HCV) genotype (gt) 1 RNA replication that lacks activity against HCV gt2. We analyzed the Los Alamos HCV sequence database to predict susceptible/resistant HCV gt's according to the prevalence of known resistance-conferring amino acids in the NS4B protein. Our analysis predicted that HCV gt3 would be highly susceptible to the activity of PTC725. Indeed, PTC725 was shown to be active against a gt3 subgenomic replicon with a 50% effective concentration of ∼5 nM. De novo resistance selection identified mutations encoding amino acid substitutions mapping to the first predicted transmembrane region of NS4B, a finding consistent with results for PTC725 and other NS4B-targeting compounds against HCV gt1. This is the first report of the activity of an NS4B targeting compound against HCV gt3. In addition, we have identified previously unreported amino acid substitutions selected by PTC725 treatment which further demonstrate that these compounds target the NS4B first transmembrane region. PMID:27620477

  3. The Risk of Relapse in Papillary Thyroid Cancer (PTC) in the Context of BRAFV600E Mutation Status and Other Prognostic Factors.

    Science.gov (United States)

    Czarniecka, Agnieszka; Kowal, Monika; Rusinek, Dagmara; Krajewska, Jolanta; Jarzab, Michal; Stobiecka, Ewa; Chmielik, Ewa; Zembala-Nozynska, Ewa; Poltorak, Stanislaw; Sacher, Aleksander; Maciejewski, Adam; Zebracka-Gala, Jadwiga; Lange, Dariusz; Oczko-Wojciechowska, Malgorzata; Handkiewicz-Junak, Daria; Jarzab, Barbara

    2015-01-01

    The risk of over-treatment in low-advanced PTC stages has prompted clinicians to search for new reliable prognostic factors. The presence of BRAF mutation, the most frequent molecular event in PTC, seems to be a good candidate. However, there is still lack of randomised trials and its significance has been proved by retrospective analyses, involving a large group of patients. The question arises whether this factor is useful in smaller populations, characterised for specialised centres. Thus, the aim of the study was to evaluate the use of BRAF mutation as a potential predictive marker in PTC patients. 233 PTC subjects treated between 2004-2006, were retrospectively analysed. Stage pT1 was diagnosed in 64.8% patients and lymph node metastases in 30.9%. Median follow-up was 7.5 years. BRAFV600E mutation was assessed postoperatively in all cases. BRAF V600E mutation was found in 54.5%. It was more frequent in patients > 45 years (p=0.0001), and associated with larger tumour size (p=0.004). Patients with tumours PTC recurrence is mainly related to the presence of lymph node metastases and extrathyroidal invasion, whereas no impact of BRAF V600E mutation has been demonstrated.

  4. PERFORMANCE CHARACTERISTICS OF PARABOLIC SOLAR COLLECTOR WATER HEATER SYSTEM FITTED WITH NAIL TWISTED TAPES ABSORBER

    Directory of Open Access Journals (Sweden)

    K. SYED JAFAR

    2017-03-01

    Full Text Available In this paper, the experimental heat transfer, friction loss and thermal performance data for water flowing through the absorber tube fitted with two different twisted tape configurations in parabolic trough collector (PTC are presented. In the present work, a relative experimental study is carried out to investigate the performance of a PTC influenced by heat transfer through fluidabsorber wall mixing mechanism. The major findings of this experiment show that heat transport enhancement in the nail twisted tape collector perform significantly better than plain twisted tapes and also show that the smallest twisted tape ratio enhances the system performance remarkably maximizing the collector efficiency. The results suggest that the twisted tape and nail twisted tape would be a better option for high thermal energy collection in laminar region of the PTC system.

  5. Effects of heater location and heater size on the natural convection heat transfer in a square cavity using finite element method

    Energy Technology Data Exchange (ETDEWEB)

    Ngo, Ich Long; Byon, Chan [Yeungnam University, Gyeongsan (Korea, Republic of)

    2015-07-15

    Finite element method was used to investigate the effects of heater location and heater size on the natural convection heat transfer in a 2D square cavity heated partially or fully from below and cooled from above. Rayleigh number (5 X 10{sup 2} ≤ Ra ≤ 5X10{sup 5}), heater size (0.1 ≤ D/L ≤ 1.0), and heater location (0.1 ≤ x{sub h}/L ≤ 0.5) were considered. Numerical results indicated that the average Nusselt number (Nu{sub m}) increases as the heater size decreases. In addition, when x{sub h}/L is less than 0.4, Nu{sub m} increases as x{sub h}/L increases, and Num decreases again for a larger value of x{sub h}/L. However, this trend changes when Ra is less than 10{sup 4}, suggesting that Nu{sub m} attains its maximum value at the region close to the bottom surface center. This study aims to gain insight into the behaviors of natural convection in order to potentially improve internal natural convection heat transfer.

  6. Experimental analysis of distinct design of a batch solar water heater with integrated collector storage system

    Directory of Open Access Journals (Sweden)

    Varghese Jaji

    2007-01-01

    Full Text Available The performance of a new design of batch solar water heater has been studied. In this system, the collector and storage were installed in one unit. Unlike the conventional design consisting of small diameter water tubes, it has a single large diameter drum which serves the dual purpose of absorber tube and storage tank. In principle it is a compound parabolic collector. The drum is sized to have a storage capacity of 100 liter to serve a family of four persons. The tests were carried out with a single glass cover and two glass covers. The tests were repeated for several days. Performance analysis of the collector has revealed that it has maximum mean daily efficiency with two glass covers as high as 37.2%. The maximum water temperature in the storage tank of 60°C has been achieved for a clear day operation at an average solar beam radiation level of 680 W/m2 and ambient temperature of 32°C. To judge the operating characteristics and to synchronize utility pattern of the collector, the different parameters such as efficiency, mean plate temperature and mass flow rate has been investigated.

  7. Comparative analysis of the electroactive area of Pt/C PEMFC electrodes in liquid and solid polymer contact by underpotential hydrogen adsorption/desorption

    Energy Technology Data Exchange (ETDEWEB)

    Chaparro, A.M.; Martin, A.J.; Folgado, M.A.; Gallardo, B. [Dep. de Energia, CIEMAT, Avda. Complutense, 22, 28040 Madrid (Spain); Daza, L. [Dep. de Energia, CIEMAT, Avda. Complutense, 22, 28040 Madrid (Spain); Instituto de Catalisis y Petroleoquimica (CSIC), Marie Curie 2, Campus Cantoblanco, 28049 Madrid (Spain)

    2009-06-15

    Because of the different experimental conditions found in literature for the measurement of the electroactive area of Pt/C electrodes of proton exchange membrane fuel cells (PEMFC) by means of underpotential hydrogen adsorption (H{sub UPD}) voltammetry, specially concerning sweep rate and temperature, it was found necessary to perform an analysis of these parameters. With this aim, the electroactive area of PEMFC electrodes has been measured by means of H{sub UPD} voltammetry at different sweep rates and temperatures, in liquid electrolyte and solid polymer contact. Both configurations show that H{sub UPD} adsorption and desorption charges are strongly dependent on sweep rate voltage and temperature. The most common behaviour observed is a maximum in H{sub UPD} desorption charge, typically in the 100-10 mV s{sup -1} sweep rate range, whereas H{sub UPD} adsorption charge shows continuous increase with decreasing sweep rate. The decrease of desorption charge at low sweep rates is attributed to adsorbing species related with carbon support reactivity. These processes are also responsible for the increase in desorption H{sub UPD} charge at low sweep rate. At high sweep rate, both adsorption and desorption H{sub UPD} charges decrease due to limiting diffusion of protons through the microporous electrode. As a consequence, it is found that the closest approximation to the real electroactive area (i.e. the area accessible to protons) corresponds to the maximum in the H{sub UPD} desorption charge in the range of 10-100 mV s{sup -1} sweep rate. The influence of measuring temperature is also tested in the range 25 C-80 C. A dependence of the adsorption and desorption hydrogen charges is found, due to thermodynamic and kinetics factors. We observe that the processes competing with hydrogen adsorption, i.e. generation and adsorption of carbon species are enhanced with temperature, so a low measuring temperature is found as most appropriate. (author)

  8. Detection of PAX8/PPARG and RET/PTC Rearrangements Is Feasible in Routine Air-Dried Fine Needle Aspiration Smears

    DEFF Research Database (Denmark)

    Ferraz, Carolina; Rehfeld, Christian; Krogdahl, Annelise;

    2012-01-01

    Background: The diagnostic limitations of fine needle aspiration (FNA), like the indeterminate category, can be partially overcome by molecular analysis. As PAX8/PPARG and RET/PTC rearrangements have been detected in follicular thyroid carcinomas (FTCs) and papillary thyroid carcinomas (PTCs...... as generally not suitable for testing these rearrangements in a clinical setting. Therefore, the objective of the present study was to investigate the feasibility of extracting RNA from routine air-dried FNA smears for the detection of these rearrangements with real-time polymerase chain reaction (RT......-PCR). Methods: A new method for RNA extraction from routine air-dried FNA smears was established, which allowed analysis for the presence of four variants of PAX8/PPARG and RET/PTC 1 and RET/PTC 3, which were analyzed in 106 routine FNA smears and the corresponding surgically obtained FFPE tissues using real...

  9. Relevance of BRAF(V600E) mutation testing versus RAS point mutations and RET/PTC rearrangements evaluation in the diagnosis of thyroid cancer.

    Science.gov (United States)

    Rossi, Martina; Buratto, Mattia; Tagliati, Federico; Rossi, Roberta; Lupo, Sabrina; Trasforini, Giorgio; Lanza, Giovanni; Franceschetti, Paola; Bruni, Stefania; Degli Uberti, Ettore; Zatelli, Maria Chiara

    2015-02-01

    A molecular profile including BRAF and RAS mutations as well as RET/PTC rearrangement evaluation has been proposed to provide an accurate presurgical assessment of thyroid nodules and to reduce the number of unnecessary diagnostic surgeries, sparing patients' health and saving healthcare resources. However, the application of such molecular analyses may provide different results among different centers and populations in real-life settings. Our aims were to evaluate the diagnostic utility of assessing the presence of BRAF and RAS mutations and RET/PTC1 and RET/PTC3 rearrangements in all cytological categories in an Italian group of thyroid nodule patients assessed prospectively, and to understand whether and which mutation testing might be helpful in cytologically indeterminate nodules. A total of 911 patients were submitted to ultrasound and fine-needle aspiration biopsy examination. Cytological evaluation was performed in parallel with molecular testing and compared to pathological results in 940 thyroid nodules, including 140 indeterminate lesions. BRAF mutation testing provided the best contribution to cancer diagnosis, allowing the disease to be detected at an early stage, and identifying indeterminate nodules in which diagnostic lobectomy could be spared. On the contrary, RAS and RET/PTC analysis did not further increase diagnostic sensitivity for thyroid cancer. In addition, we found RET/PTC rearrangements in benign lesions, indicating that this molecular marker might not be useful for the detection of thyroid cancer. BRAF(V600E) mutation analysis is superior to RAS point mutations and evaluation of RET/PTC rearrangements in the diagnosis of thyroid cancer, even in indeterminate lesions.

  10. Stop codon read-through with PTC124 induces palmitoyl-protein thioesterase-1 activity, reduces thioester load and suppresses apoptosis in cultured cells from INCL patients

    Science.gov (United States)

    Sarkar, Chinmoy; Zhang, Zhongjian; Mukherjee, Anil B.

    2011-01-01

    Infantile neuronal ceroid lipofuscinosis (INCL), a lethal hereditary neurodegenerative lysosomal storage disorder, affects mostly children. It is caused by inactivating mutations in the palmitoyl-protein thioesterase-1 (PPT1) gene. Nonsense mutations in a gene generate premature termination codons producing truncated, nonfunctional or deleterious proteins. PPT1 nonsense-mutations account for approximately 31% of INCL patients in the US. Currently, there is no effective treatment for this disease. While aminoglycosides such as gentamycin suppress nonsense mutations, inherent toxicity of aminoglycosides prohibits chronic use in patients. PTC124 is a non-toxic compound that induces ribosomal read-through of premature termination codons. We sought to determine whether PTC124-treatment of cultured cells from INCL patients carrying nonsense mutations in the PPT1 gene would correct PPT1 enzyme-deficiency with beneficial effects. Our results showed that PTC124-treatment of cultured cells from INCL patients carrying PPT1 nonsense-mutations induced PPT1 enzymatic activity in a dose- and time-dependent manner. This low level of PPT1 enzyme activity induced by PTC124 is virtually identical to that induced by gentamycin-treatment. Even though only a modest increase in PPT1 activity was achieved by PTC124-treatment of INCL cells, this treatment reduced the levels of thioester (constituent of ceroid) load. Our results suggest that PTC124-treatment induces PPT1 enzymatic activity in cultured cells from INCL patients carrying PPT1 nonsense-mutations, and this modest enzymatic activity has demonstrable beneficial effects on these cells. The clinical relevance of these effects may be tested in animal models of INCL carrying nonsense mutations in the PPT1 gene. PMID:21704547

  11. Differential expression profiling of circulation microRNAs in PTC patients with non-131I and 131I-avid lungs metastases: a pilot study.

    Science.gov (United States)

    Qiu, Zhong-Ling; Shen, Chen-Tian; Song, Hong-Jun; Wei, Wei-Jun; Luo, Quan-Yong

    2015-05-01

    Loss of the ability to concentrate (131)I is one of the important causes of radioiodine-refractory disease in papillary thyroid carcinoma (PTC). Recent advantages of serum microRNAs (miRNAs) open a new realm of possibilities for noninvasive diagnosis and prognosis of many cancers. The aim of the current study was to identify differential expression profiling of circulation miRNAs in PTC patients with non-(131)I and (131)I-avid lungs metastases. The expressions of miRNAs were examined using miRNA microarray chip. The most significantly changed miRNAs from microarray were verified by using qRT-PCR. The potential miRNAs regulating target genes and their preliminary biological functions were forecasted by Bioinformatic analysis. Compared to (131)I-avid lung metastases, 13 kinds of significantly differential serum miRNAs including 5 upregulated miRNAs (miR-1249, miR-106a, miR-503, miR-34c-5p, miR-1281) and 8 downregulated miRNAs (miR-1915, miR-2861, miR-3196, miR-500, miR-572, miR-33b, miR-554, miR-18a) in PTC patients with non-(131) I-avid lung metastases were identified. Bioinformatic analysis demonstrated that miR-106a was the core miRNA regulating 193 genes in the network. The results of validation confirmed the up-regulation of miR-106a in non-(131)I-avid lungs metastatic PTC patients. Differentially expressed serum miRNA profiles between PTC patients with non-(131)I and (131)I-avid lungs metastases were analyzed. These findings in our present study could represent new clues for the diagnostic and therapeutic strategy in PTC patients with non-(131)I-avid metastatic disease. Copyright © 2015 Elsevier Inc. All rights reserved.

  12. Effect of heat recovery water heater system on the performance of residential split air conditioner using hydrocarbon refrigerant (HCR22)

    Science.gov (United States)

    Aziz, A.; Thalal; Amri, I.; Herisiswanto; Mainil, A. K.

    2017-09-01

    This This paper presents the performance of residential split air conditioner (RSAC) using hydrocarbon refrigerant (HCR22) as the effect on the use of heat recovery water heater system (HRWHS). In this study, RSAC was modified with addition of dummy condenser (trombone coil type) as heat recovery water heater system (HRWHS). This HRWHS is installed between a compressor and a condenser by absorbing a part of condenser waste heat. The results show that RSAC with HRWHS is adequate to generate hot water with the temperature range about 46.58˚C - 48.81˚C when compared to without HRWHS and the use of dummy condenser does not give significant effect to the split air conditioner performance. When the use of HRWHS, the refrigerant charge has increase about 19.05%, the compressor power consumption has slightly increase about 1.42% where cooling capacity almost the same with slightly different about 0.39%. The condenser heat rejection is lower about 2.68% and the COP has slightly increased about 1.05% when compared to without HRWHS. The use of HRWHS provide free hot water, it means there is energy saving for heating water without negative impact to the system performance of RSAC.

  13. Swift BAT Thermal Recovery After Loop Heat Pipe #0 Secondary Heater Controller Failure in October 2015

    Science.gov (United States)

    Choi, Michael K.

    2016-01-01

    The Swift BAT LHP #0 primary heater controller failed on March 31, 2010. It has been disabled. On October 31, 2015, the secondary heater controller of this LHP failed. On November 1, 2015, the LHP #0 CC temperature increased to as 18.6 C, despite that the secondary heater controller set point was 8.8 C. It caused the average DM XA1 temperature to increase to 25.9 C, which was 5 C warmer than nominal. As a result, the detectors became noisy. To solve this problem, the LHP #1 secondary heater controller set point was decreased in 0.5 C decrements to 2.2 C. The set-point decrease restored the average DM XA1 temperature to a nominal value of 19.7 C on November 21.

  14. Numerical Simulation of Induction Through-Heater in Dynamic Operation Mode

    Directory of Open Access Journals (Sweden)

    SCURTU Gheorghe Lucian

    2013-05-01

    Full Text Available The numeric model used in this paper is based on the finite element method and is aiming an inductive heating in volume of a cylindrical structure in a dynamic operation mode. Nowadays the inductionthrough-heaters are usually designed to provide the required characteristics in “quasi” steady-state operation mode mainly. However, in industrial practice the heaters can operate under various disturbances more than half of time, so the transient process playsignificant role in effectiveness and quality of the heating. Investigation of dynamic characteristics of the heaters in dynamic modes can be only done by numerical modeling based on special algorithms providing a time loop additionally to coupling betweenelectromagnetic and thermal analysis. Such numerical models have been developed and used for investigation of dynamic modes for heating billets. The results of numerical simulation can be used for design ofinduction through-heaters and improvement of their characteristics in dynamic operation modes.

  15. Analytical model for ring heater thermal compensation in the Advanced Laser Interferometer Gravitational-wave Observatory.

    Science.gov (United States)

    Ramette, Joshua; Kasprzack, Marie; Brooks, Aidan; Blair, Carl; Wang, Haoyu; Heintze, Matthew

    2016-04-01

    Advanced laser interferometer gravitational-wave detectors use high laser power to achieve design sensitivity. A small part of this power is absorbed in the interferometer cavity mirrors where it creates thermal lenses, causing aberrations in the main laser beam that must be minimized by the actuation of "ring heaters," which are additional heater elements that are aimed to reduce the temperature gradients in the mirrors. In this article we derive the first, to the best of our knowledge, analytical model of the temperature field generated by an ideal ring heater. We express the resulting optical aberration contribution to the main laser beam in this axisymmetric case. Used in conjunction with wavefront measurements, our model provides a more complete understanding of the thermal state of the cavity mirrors and will allow a more efficient use of the ring heaters in the Advanced Laser Interferometer Gravitational-wave Observatory.

  16. Self-regulating heater application to Shuttle/Centaur hydrazine fuel line thermal control

    Science.gov (United States)

    Unkrich, David B.

    1987-01-01

    The Shuttle/Centaur high energy upper stage vehicle thermal environments were more severe than previous Centaur vehicle thermal environments, creating need for a new hydrazine fuel line thermal control technique. Constant power heaters did not satisfy power dissipation requirements, because the power required to maintain fuel line thermal control during cold conditions exceeded the maximum power allowable during hot conditions. Therefore, a Raychem Thermolimit self-regulating heater was selected for this application, and was attached to the hydrazine fuel line with Kapton and aluminum foil tapes. Fuel line/heater thermal modeling and subsequent thermal vacuum chamber testing simulated heater thermal performance during all worst-case Shuttle/Centaur thermal environmental conditions. Fuel line temperatures were maintained between the 4C to 71C limits during all analytical and test cases. Finally, the thermal model predictions were correlated with the test data, thereby ensuring that the model would provide satisfactory predictions for future missions and/or vehicles.

  17. REFINED METHOD OF COMPUTING MODES OF OPERATING OF CAPACITY-TYPE SOLAR HEATERS OF

    Directory of Open Access Journals (Sweden)

    Ermuratschii Vl.V.

    2008-04-01

    Full Text Available The refined method procedure of thermal modes of solar heaters of water of the capacity type, based on use of an electro-thermal equivalent circuit and a method of central potentials is presented.

  18. Towards the Development of a Novel CNTs-based Flexible Mild Heater for Art Conservation

    Directory of Open Access Journals (Sweden)

    Tomas Markevicius

    2014-03-01

    tests performed on a series of prototypes of the designed heaters showed that the device was able to convey uniform heating on different working materials, thus proving to be effective for thermal consolidation.

  19. Temperature Profiles During Quenches in LHC Superconducting Dipole Magnets Protected by Quench Heaters

    CERN Document Server

    Maroussov, V; Siemko, A

    2000-01-01

    The efficiency of the magnet protection by quench heaters was studied using a novel method which derives the temperature profile in a superconducting magnet during a quench from measured voltage signals. In several Large Hadron Collider single aperture dipole models, temperature profiles and temperature gradients in the magnet coil have been evaluated in the case of protection by different sets of quench heaters and different powering and protection parameters. The influence of the insulation thickness between the quench heaters and the coil has also been considered. The results show clear correlation between the positions of quench heaters, magnet protection parameters and temperature profiles. This study allowed a better understanding of the quench process mechanisms and the efficiency assessment of the different protection schemes.

  20. Natural Convection of Nanofluids in a Square Enclosure with a Protruding Heater

    Directory of Open Access Journals (Sweden)

    J. Guiet

    2012-01-01

    Full Text Available This paper reports a numerical study on natural convection from a protruding heater located at the bottom of a square cavity filled with a copper-water nanofluid. The vertical walls of the cavity are cooled isothermally; the horizontal ones are adiabatic, and the heater is attached to the bottom wall. The heat source is assumed either to be isothermal or to have a constant heat flux. The effective viscosity and thermal conductivity of the nanofluid are modeled according to Brinkman and Patel, respectively. Numerical solutions of the full-governing equations, based on the lattice Boltzmann method, are obtained for a wide range of the governing parameters: the Rayleigh number, Ra; the Prandtl number, Pr; the geometrical parameters specifying the heater; the volume fraction of nanoparticles, Φ. For a particular geometry, it has been found that, for a given Ra, heat transfer is enhanced with increasing Φ, independently of the thermal boundary condition applied on the heater.

  1. Ultrathin Polyimide-Stainless Steel Heater for Vacuum System Bake-out

    CERN Document Server

    Rathjen, Christian; Henrist, Bernard; Kölemeijer, Wilhelmus; Libera, Bruno; Lutkiewicz, Przemyslaw

    2005-01-01

    Space constraints in several normal conducting magnets of the LHC required the development of a dedicated permanent heater for vacuum chamber bake-out. The new heater consists of stainless steel bands inside layers of polyimide. The overall heater thickness is about 0.3 mm. The low magnetic permeability is suitable for applications in magnetic fields. The material combination allows for temperatures high enough to activate a NEG coating. Fabrication is performed in consecutive steps of tape wrapping. Automation makes high volume production at low costs possible. About 800 m of warm vacuum system of the long straight sections of the LHC will be equipped with the new heater. This paper covers experience gained at CERN from studies up to industrialization.

  2. A Simple Substrate Heater Device With Temperature Controller for Thin Film Preparation

    Directory of Open Access Journals (Sweden)

    G. Rendón

    2012-08-01

    Full Text Available A simple substrate heater and its temperature controller were designed and built in order to prepare thin films in a highvacuum deposition system. The substrate heater was elaborated with a glass-ceramic body and a molybdenum foilheater. The applied power and the temperature are regulated by a power controller board using a microcontrollerprogrammed with a proportional-integrative-derivative algorithm. The heater/controller system was tested in a highvacuum deposition system and the results of its characterization at 100, 200, 300 and 400 °C are presented. Avariation in temperature better than ± 0.5 °C was obtained for all the tested temperatures. An application of thesubstrate heater is demonstrated by evaporating gold thin films on heated glass substrates.

  3. Technical support document: Energy efficiency standards for consumer products: Room air conditioners, water heaters, direct heating equipment, mobile home furnaces, kitchen ranges and ovens, pool heaters, fluorescent lamp ballasts and television sets. Volume 3, Water heaters, pool heaters, direct heating equipment, and mobile home furnaces

    Energy Technology Data Exchange (ETDEWEB)

    1993-11-01

    This is Volume 3 in a series of documents on energy efficiency of consumer products. This volume discusses energy efficiency of water heaters. Water heaters are defined by NAECA as products that utilize oil, gas, or electricity to heat potable water for use outside the heater upon demand. These are major appliances, which use a large portion (18% on average) of total energy consumed per household (1). They differ from most other appliances in that they are usually installed in obscure locations as part of the plumbing and are ignored until they fail. Residential water heaters are capable of heating water up to 180{degrees}F, although the setpoints are usually set lower.

  4. Energetic Performances Study of an Integrated Collector Storage Solar Water Heater

    Directory of Open Access Journals (Sweden)

    O. Helal

    2010-01-01

    Full Text Available Problem statement: Although that the interest attributed to the solar energy remains relatively limited, we attend today to the conception of several installations using the sun as energy source among which we quote the solar water heater. Approach: A study of energetic performances was taken on an integrated collector/storage solar water heater made in the National School of Engineers of Gabes. This water heater is equipped with a concentration system containing a reflector composed of three parabolic branches favorating a better absorption of solar radiance. Results: The comparison between this system and two other systems of solar water heater, composed of a storage ball with asymmetrical CPC and symmetrical CPC, showed important energetic performances despite the simplicity and the little cost of the collector. Conclusion: Several improvements are necessary to increase the direct flow whilst decrease the thermal losses and therefore make the system simpler to be installed on the building roof.

  5. Energy-efficient tunable silicon photonic micro-resonator with graphene transparent nano-heaters

    CERN Document Server

    Yu, Longhai; Dai, Daoxin; He, Sailing

    2015-01-01

    Thermally-tuning silicon micro-cavities are versatile and beneficial elements in low-cost large-scale photonic integrated circuits (PICs). Traditional metal heaters used for thermal tuning in silicon micro-cavities usually need a thick SiO2 upper-cladding layer, which will introduce some disadvantages including low response speed, low heating efficiency, low achievable temperature and complicated fabrication processes. In this paper, we propose and experimentally demonstrate thermally-tuning silicon micro-disk resonators by introducing graphene transparent nano-heaters, which contacts the silicon core directly without any isolator layer. This makes the graphene transparent nano-heater potentially to have excellent performances in terms of the heating efficiency, the temporal response and the achievable temperature. It is also shown that the graphene nano-heater is convenient to be used in ultrasmall photonic integrated devices due to the single-atom thickness and excellent flexibility of graphene. Both experi...

  6. Analysis of exergy and parametric study of a v-corrugated solar air heater

    Energy Technology Data Exchange (ETDEWEB)

    Hedayatizadeh, Mahdi [University of Tabriz, Department of Agricultural Machinery Engineering, Faculty of Agriculture, Tabriz (Iran, Islamic Republic of); University of Birjand, Faculty of Agriculture, P.O. Box 97175/331, Birjand (Iran, Islamic Republic of); Ajabshirchi, Yahya [University of Tabriz, Department of Agricultural Machinery Engineering, Faculty of Agriculture, Tabriz (Iran, Islamic Republic of); Sarhaddi, Faramarz; Farahat, Said [University of Sistan and Baluchestan, Department of Mechanical Engineering, Faculty of Engineering, P.O. Box 98164/161, Zahedan (Iran, Islamic Republic of); Safavinejad, Ali [University of Birjand, Department of Mechanical Engineering, Faculty of Engineering, Birjand (Iran, Islamic Republic of); Chaji, Hossein [University of Tabriz, Department of Agricultural Machinery Engineering, Faculty of Agriculture, Tabriz (Iran, Islamic Republic of); Center of Agriculture and Natural Resources of Khorasan Razavi Province, Ministry of Agriculture, Mashhad (Iran, Islamic Republic of)

    2012-07-15

    Solar air heater requires investigation for enhancement of solar energy conversion into heat. Different configurations with various artificial roughness geometries are proposed to date. In present study attention is paid on ways leading to more delivery of exergy by a v-corrugated solar air heater through parametric study. Effects of aspect ratio of the collector, inlet air temperature, mass flow rate per collector area etc. are studied. (orig.)

  7. Economics of residential gas furnaces and water heaters in US new construction market

    OpenAIRE

    Lekov, Alex B.; Franco, Victor H.; Wong-Parodi, Gabrielle; McMahon, James E.; CHAN, Peter

    2010-01-01

    New single-family home construction represents a significant and important market for the introduction of energy-efficient gas-fired space heating and water-heating equipment. In the new construction market, the choice of furnace and water-heater type is primarily driven by first cost considerations and the availability of power vent and condensing water heaters. Few analysis have been performed to assess the economic impacts of the different combinations of space and water-heating equipment....

  8. Economics of residential gas furnaces and water heaters in United States new construction market

    OpenAIRE

    Lekov, Alex B.

    2010-01-01

    New single-family home construction represents a significant and important market for the introduction of energy-efficient gas-fired space heating and water-heating equipment. In the new construction market, the choice of furnace and water-heater type is primarily driven by first cost considerations and the availability of power vent and condensing water heaters. Few analysis have been performed to assess the economic impacts of the different combinations of space and water-heating equipment....

  9. PREDICTION OF OPTIMUM ANGLE OF SOLAR WATER HEATER FOR COIMBATORE LOCATION

    OpenAIRE

    M. Sekar; DR M. SAKTHIVEL; O. MANIYARASU; N.ALAGU MURUGAN

    2013-01-01

    The objective of this work was to investigate ways to enhance the performance of solar water heater system to encourage many households using it. The integrated collector storage is the type of solar water heater that has retained its existence for well over a century. The flat absorber plate integrated collector storage type is a relatively recent addition. Being effective, low cost and simple to manufacture, their importance has been further enhanced by the recent upsurge in efforts to effe...

  10. On the teaching of the relationship between genes and taste-blindness of phenylthiocarbamide(PTC)%对"基因和苯硫脲(PTC)味盲的关系"的教学探讨

    Institute of Scientific and Technical Information of China (English)

    王苏豫

    2010-01-01

    以"基因和苯硫脲(PTC)味盲的关系"的教学为例,对研究性学习的教学内容和方法进行了初步探讨.针对基因和苯硫脲味盲的关系的研究,从问题的提出、假设的形成和实验所涉及的实验试剂的配制、试剂浓度、尝味方法多方面引导学生进行讨论,力图通过生物学教学中真实的科学研究过程,提高学生的生物科学素养.

  11. PREDICTION OF OPTIMUM ANGLE OF SOLAR WATER HEATER FOR COIMBATORE LOCATION

    Directory of Open Access Journals (Sweden)

    M. SEKAR

    2013-04-01

    Full Text Available The objective of this work was to investigate ways to enhance the performance of solar water heater system to encourage many households using it. The integrated collector storage is the type of solar water heater that has retained its existence for well over a century. The flat absorber plate integrated collector storage type is a relatively recent addition. Being effective, low cost and simple to manufacture, their importance has been further enhanced by the recent upsurge in efforts to effectively tap renewable energy resources. Having different inclinations based on latitude, the design of flat plate heaters can benefit from extensive amount of research on the topic of natural convection in inclined cavities. The thermal performance of the heater is recorded experimentally at angles 0°–30° from horizontal, in 10° intervals. It was found that for any given constant value of heat flux, the performance of the heater is a strong function of the angle of inclination. The optimum configuration of the heater for Coimbatore location is also evaluated.

  12. Energy Savings and Breakeven Cost for Residential Heat Pump Water Heaters in the United States

    Energy Technology Data Exchange (ETDEWEB)

    Maguire, J.; Burch, J.; Merrigan, T.; Ong, S.

    2013-07-01

    Heat pump water heaters (HPWHs) have recently reemerged in the U.S. residential water heating market and have the potential to provide homeowners with significant energy savings. However, there are questions as to the actual performance and energy savings potential of these units, in particular in regards to the heat pump's performance in unconditioned space and the impact of the heat pump on space heating and cooling loads when it is located in conditioned space. To help answer these questions, simulations were performed of a HPWH in both conditioned and unconditioned space at over 900 locations across the continental United States and Hawaii. Simulations included a Building America benchmark home so that any interaction between the HPWH and the home's HVAC equipment could be captured. Comparisons were performed to typical gas and electric water heaters to determine the energy savings potential and cost effectiveness of a HPWH relative to these technologies. HPWHs were found to have a significant source energy savings potential when replacing typical electric water heaters, but only saved source energy relative to gas water heater in the most favorable installation locations in the southern US. When replacing an electric water heater, the HPWH is likely to break even in California, the southern US, and parts of the northeast in most situations. However, the HPWH will only break even when replacing a gas water heater in a few southern states.

  13. Energy Savings and Breakeven Costs for Residential Heat Pump Water Heaters in the United States

    Energy Technology Data Exchange (ETDEWEB)

    Maguire, Jeff [National Renewable Energy Lab. (NREL), Golden, CO (United States); Burch, Jay [National Renewable Energy Lab. (NREL), Golden, CO (United States); Merrigan, Tim [National Renewable Energy Lab. (NREL), Golden, CO (United States); Ong, Sean [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2013-07-01

    Heat pump water heaters (HPWHs) have recently re-emerged in the U.S. residential water heating market and have the potential to provide homeowners with significant energy savings. However, there are questions as to the actual performance and energy savings potential of these units, in particular in regards to the heat pump's performance in unconditioned space and the impact of the heat pump on space heating and cooling loads when it is located in conditioned space. To help answer these questions, NREL performed simulations of a HPWH in both conditioned and unconditioned space at over 900 locations across the continental United States and Hawaii. Simulations included a Building America benchmark home so that any interaction between the HPWH and the home's HVAC equipment could be captured. Comparisons were performed to typical gas and electric water heaters to determine the energy savings potential and cost effectiveness of a HPWH relative to these technologies. HPWHs were found to have a significant source energy savings potential when replacing typical electric water heaters, but only saved source energy relative to gas water heater in the most favorable installation locations in the southern United States. When replacing an electric water heater, the HPWH is likely to break even in California, the southern United States, and parts of the northeast in most situations. However, the HPWH will only break even when replacing a gas water heater in a few southern states.

  14. Solair heater program: solair applications study. Final report

    Energy Technology Data Exchange (ETDEWEB)

    1977-12-01

    General Electric has designed and tested a low-cost solar system using a vacuum tube solar air heater under ERDA Contract E(11-1)-2705. This contract extension has been provided to evaluate various applications of this solar collector. The evaluation identified attractive applications, evaluated corresponding control procedures, estimated system performance, compared economically insolation and insulation, and evaluated the repackaging of off-the-shelf equipment for improved cost effectiveness. The results of this study prompted General Electric's marketing group to do a detailed commercialization study of a residential domestic water heating system using the Solair concept which has been selected as the most attractive application. Other attractive applications are space/domestic water heating and a heat pump assisted solar system/domestic water heating where the heat pump and the solar system function in parallel. A prime advantage of heated air solar systems over liquid systems is cost and longer life which results in higher BTU's/dollar. Other air system advantages are no liquid leakage problems, no toxicity of freezing problems, and less complicated equipment. A hybrid solar system has been identified that can improve the market penetration of solar energy. This system would use the existing mass of the house for energy storage thereby reducing solar cost and complexity. Adequate performance can be obtained with house temperature swings comparable to those used in nighttime setback of the thermostat. Details of this system are provided.

  15. Solar Biogas Digester with Built-In Reverse Absorber Heater

    Directory of Open Access Journals (Sweden)

    Khasan S. Karimov

    2013-01-01

    Full Text Available In this work the design, fabrication and investigation of a solar biogas digester with built-in RAH (Reverse Absorber Heater is presented. The maximum temperature (50 o C inside of the methane tank was taken as a main parameter at the design of the digester. Using energy balance equation for the case of a static mass of fluid being heated; the parameters of thermal insulation of the methane tank were counted. The biogas digester is consisting of methane tank with built-in solar RAH to utilize solar energy for the heating of the slurry prepared from the different organic wastes (dung, sewage, food wastes etc. The methane tank was filled up to 70% of volume by organic wastes of the GIK Institute sewage, firstly, and secondly, by sewage and cow dung as well. During three months (October-December, 2009 and two months (February-March, 2010 the digester was investigated. The solar irradiance incident to the absorber, slurry's temperature and ambient temperature were measured. It was found that using sewage only and sewage with cow dung the retention times was 4 weeks and two weeks respectively and biogas quantity produced was 0.4 and 8.0 m 3 respectively. In addition, biogas upgradation scheme for removal of carbon dioxide, hydrogen sulphide and water vapor from biogas and conversion of biogas energy conversion into electric power is also discussed.

  16. Light-weight radioisotope heater unit (LWRHU) impact tests

    Science.gov (United States)

    Reimus, M. A. H.; Rinehart, G. H.; Herrera, A.; Lopez, B.; Lynch, C.; Moniz, P.

    1998-01-01

    The light-weight radioisotope heater unit (LWRHU) is a 238PuO2-fueled heat source designed to provide one thermal watt in each of various locations on a spacecraft. Los Alamos National Laboratory designed, fabricated, and safety tested the LWRHU. The heat source consists of a hot-pressed 238PuO2 fuel pellet, a Pt-30Rh vented capsule, a pyrolytic graphite insulator, and a fineweave-pierced fabric graphite aeroshell assembly. To compare the performance of the LWRHUs fabricated for the Cassini mission with the performance of those fabricated for the Galileo mission, and to determine a failure threshold, two types of impact tests were conducted. A post-reentry impact test was performed on one of 180 flight-quality units produced for the Cassini mission and a series of sequential impact tests using simulant-fueled LWRHU capsules were conducted respectively. The results showed that deformation and fuel containment of the impacted Cassini LWRHU was similar to that of a previously tested Galileo LWRHU. Both units sustained minimal deformation of the aeroshell and fueled capsule; the fuel was entirely contained by the platinum capsule. Sequential impacting, in both end-on and side-on orientations, resulted in increased damage with each subsequent impact. Sequential impacting of the LWRHU appears to result in slightly greater damage than a single impact at the final impact velocity of 50 m/s.

  17. Generation of Acoustic Gravity Waves by Periodic Radio Transmissions from a High-Power Ionospheric Heater

    Science.gov (United States)

    Frolov, Vladimir; Chernogor, Leonid; Rozumenko, Victor

    the F _{_2} layer critical frequency. High-power periodic radio transmissions are capable of enhancing/damping natural wave perturbations generated by the solar terminator. 3. The study has demonstrated that the generation and propagation of AGWs with periods close to the natural oscillation periods of the atmosphere is possible. The duration of AGW oscillation trains does not dependent on the duration of turn-on/-off trains, but it is determined by changes in the current state of the atmosphere-ionosphere-magnetosphere system in general. The period of the AGW oscillation trains is determined by the period or semi-period of the pumping. It means that the mechanism of AGW generation in this case is distinct from the agreed-upon mechanism developed earlier. The AGWs, whose periods are 5 - 10% greater than the Brunt-Vaisala period, exhibit group velocities less than the speed of sound that is of about 80 - 160 m/s. They induce electron density perturbations of about 1.1 - 1.5%. The AGW generation has the following features. When the effective radiated power (ERP) is 50 MW or less, AGWs are not detected; they are reliably observed when the ERP is equal or larger than about 100 MW. Geomagnetic storms play a dual role in the AGW generation because they: (i) increase amplitudes of AGWs with 4 - 6-min and 8 - 12-min periods and (ii) yet enhance background oscillations. The latter hampers the identification of the HF-induced oscillations. Moderate magnetic storms do not markedly exert an influence on the amplitudes of oscillations with 13 - 17-min periods. 4. The quasi-periodic variations in the horizontal components of the geomagnetic field with 8 - 12-min periods become observable near Kharkiv 35 - 45 min after the beginning of pumping. Their speeds are 355 - 460 m/s, and they form trains 40 - 90 min in duration when the [5-min on, 5-min off] or [10-min on, 10-min off] heater timing is used. The 12 - 18-min period variations become observable 35 - 45 min after the beginning

  18. The effects of BRAF gene mutation on PTC lymph node metastasis in central region%BRAF基因突变对甲状腺乳头状癌(PTC)中央区淋巴结转移的影响

    Institute of Scientific and Technical Information of China (English)

    于景超; 秦华东; 石铁锋; 石臣磊

    2015-01-01

    目的:探讨BRAF基因突变对甲状腺乳头状癌(PTC)中央区淋巴结转移的相关性因素,着重研究BRAF基因突变中不同肿瘤直径对PTC的影响.方法:回顾性分析本院甲状腺外科2011年10月-2013年10月2年间手术切除的136例PTC病例,分析BRAF基因突变与相关因素之间的关系.结果:PTC中BRAF基因突变率为69.85% (95/136).BRAF基因突变阳性者颈部中央区淋巴结转移率为34.74%(33/95),BRAF基因突变阴性者中央区淋巴结转移率为12.2% (5/41),两者统计学差异具有相关性(p<0.05).肿瘤直径大于2cm时BRAF基因突变率为90.48%(19/21),直径小于等于2cm时BRAF基因突变率为66.09%(76/115),两者统计学差异具有相关性(P<0.05).结论:BRAF基因突变与PTC中央区淋巴结转移存在相关性.对于术前检测BRAF突变阳性的病例,当肿瘤直径大于2cm时应该常规清扫该中央区淋巴脂肪组织.

  19. Artificial Neural Networks-Based Software for Measuring Heat Collection Rate and Heat Loss Coefficient of Water-in-Glass Evacuated Tube Solar Water Heaters.

    Science.gov (United States)

    Liu, Zhijian; Liu, Kejun; Li, Hao; Zhang, Xinyu; Jin, Guangya; Cheng, Kewei

    2015-01-01

    Measurements of heat collection rate and heat loss coefficient are crucial for the evaluation of in service water-in-glass evacuated tube solar water heaters. However, conventional measurement requires expensive detection devices and undergoes a series of complicated procedures. To simplify the measurement and reduce the cost, software based on artificial neural networks for measuring heat collection rate and heat loss coefficient of water-in-glass evacuated tube solar water heaters was developed. Using multilayer feed-forward neural networks with back-propagation algorithm, we developed and tested our program on the basis of 915 measured samples of water-in-glass evacuated tube solar water heaters. This artificial neural networks-based software program automatically obtained accurate heat collection rate and heat loss coefficient using simply "portable test instruments" acquired parameters, including tube length, number of tubes, tube center distance, heat water mass in tank, collector area, angle between tubes and ground and final temperature. Our results show that this software (on both personal computer and Android platforms) is efficient and convenient to predict the heat collection rate and heat loss coefficient due to it slow root mean square errors in prediction. The software now can be downloaded from http://t.cn/RLPKF08.

  20. Study on Pot Forming of Induction Heater Type Rice Cookers by Forging Cast Process

    Science.gov (United States)

    Ohnishi, Masayuki; Yamaguchi, Mitsugi; Ohashi, Osamu

    This paper describes a study result on pot fabrication by the forging cast process of stainless steel with aluminum. Rice cooked with the new bowl-shaped pot for the induction heater type rice cookers is better tasting than rice cooked with the conventional cylindrical one, due to the achievement of better heat conduction and convection. The conventional pot is made of the clad sheet, consisting of stainless steel and aluminum. However, it is rather difficult to form a bowl shape from the clad sheet, primarily due to the problem of a material spring back. The fabrication of a new type of a pot was made possible by means of the adoption of a forging cast process instead of the clad sheet. In this process, iron powder is inserted between stainless steel and aluminum in order to alleviate the large difference on the coefficient of expansion between each material. It was made clear that the application of two kinds of iron particle, namely 10 μm size powder on the stainless steel side and 44 μm on the aluminum side, enables the joints to become strong enough. The joint strength of the new pot by this fabrication process was confirmed by the tests of the shear strength and the fatigue tests together with the stress analysis.

  1. Experimental and Computational Analysis of Unidirectional Flow Through Stirling Engine Heater Head

    Science.gov (United States)

    Wilson, Scott D.; Dyson, Rodger W.; Tew, Roy C.; Demko, Rikako

    2006-01-01

    A high efficiency Stirling Radioisotope Generator (SRG) is being developed for possible use in long-duration space science missions. NASA s advanced technology goals for next generation Stirling convertors include increasing the Carnot efficiency and percent of Carnot efficiency. To help achieve these goals, a multi-dimensional Computational Fluid Dynamics (CFD) code is being developed to numerically model unsteady fluid flow and heat transfer phenomena of the oscillating working gas inside Stirling convertors. In the absence of transient pressure drop data for the zero mean oscillating multi-dimensional flows present in the Technology Demonstration Convertors on test at NASA Glenn Research Center, unidirectional flow pressure drop test data is used to compare against 2D and 3D computational solutions. This study focuses on tracking pressure drop and mass flow rate data for unidirectional flow though a Stirling heater head using a commercial CFD code (CFD-ACE). The commercial CFD code uses a porous-media model which is dependent on permeability and the inertial coefficient present in the linear and nonlinear terms of the Darcy-Forchheimer equation. Permeability and inertial coefficient were calculated from unidirectional flow test data. CFD simulations of the unidirectional flow test were validated using the porous-media model input parameters which increased simulation accuracy by 14 percent on average.

  2. A comparative evaluation of NB30, NB54 and PTC124 in translational read-through efficacy for treatment of an USH1C nonsense mutation

    Science.gov (United States)

    Goldmann, Tobias; Overlack, Nora; Möller, Fabian; Belakhov, Valery; van Wyk, Michiel; Baasov, Timor; Wolfrum, Uwe; Nagel-Wolfrum, Kerstin

    2012-01-01

    Translational read-through-inducing drugs (TRIDs) promote read-through of nonsense mutations, placing them in the spotlight of current gene-based therapeutic research. Here, we compare for the first time the relative efficacies of new-generation aminoglycosides NB30, NB54 and the chemical compound PTC124 on retinal toxicity and read-through efficacy of a nonsense mutation in the USH1C gene, which encodes the scaffold protein harmonin. This mutation causes the human Usher syndrome, the most common form of inherited deaf-blindness. We quantify read-through efficacy of the TRIDs in cell culture and show the restoration of harmonin function. We do not observe significant differences in the read-through efficacy of the TRIDs in retinal cultures; however, we show an excellent biocompatibility in retinal cultures with read-through versus toxicity evidently superior for NB54 and PTC124. In addition, in vivo administration of NB54 and PTC124 induced recovery of the full-length harmonin a1 with the same efficacy. The high biocompatibilities combined with the sustained read-through efficacies of these drugs emphasize the potential of NB54 and PTC124 in treating nonsense mutation-based retinal disorders. PMID:23027640

  3. Solar dryer with thermal storage and biomass-backup heater

    Energy Technology Data Exchange (ETDEWEB)

    Madhlopa, A. [Department of Physics and Biochemical Sciences, Malawi Polytechnic, P/Bag 303, Blantyre 3 (Malawi); Ngwalo, G. [Department of Mechanical Engineering, Malawi Polytechnic, P/Bag 303, Blantyre 3 (Malawi)

    2007-04-15

    An indirect type natural convection solar dryer with integrated collector-storage solar and biomass-backup heaters has been designed, constructed and evaluated. The major components of the dryer are biomass burner (with a rectangular duct and flue gas chimney), collector-storage thermal mass and drying chamber (with a conventional solar chimney). The thermal mass was placed in the top part of the biomass burner enclosure. The dryer was fabricated using simple materials, tools and skills, and it was tested in three modes of operation (solar, biomass and solar-biomass) by drying twelve batches of fresh pineapple (Ananas comosus), with each batch weighing about 20 kg. Meteorological conditions were monitored during the dehydration process. Moisture and vitamin C contents were determined in both fresh and dried samples. Results show that the thermal mass was capable of storing part of the absorbed solar energy and heat from the burner. It was possible to dry a batch of pineapples using solar energy only on clear days. Drying proceeded successfully even under unfavorable weather conditions in the solar-biomass mode of operation. In this operational mode, the dryer reduced the moisture content of pineapple slices from about 669 to 11% (db) and yielded a nutritious dried product. The average values of the final-day moisture-pickup efficiency were 15%, 11% and 13% in the solar, biomass and solar-biomass modes of operation respectively. It appears that the solar dryer is suitable for preservation of pineapples and other fresh foods. Further improvements to the system design are suggested. (author)

  4. Emission factors of gaseous pollutants from recent kerosene space heaters and fuels available in France in 2010.

    Science.gov (United States)

    Carteret, M; Pauwels, J-F; Hanoune, B

    2012-08-01

    Laboratory measurements of the gaseous emission factors (EF) from two recent kerosene space heaters (wick and injector) with five different fuels have been conducted in an 8-m(3) environmental chamber. The two heaters tested were found to emit mainly CO(2), CO, NO, NO(2), and some volatile organic compounds (VOCs). NO(2) is continuously emitted during use, with an EF of 100-450 μg per g of consumed fuel. CO is normally emitted mainly during the first minutes of use (up to 3 mg/g). Formaldehyde and benzene EFs were quantified at 15 and 16 μg/g, respectively, for the wick heater. Some other VOCs, such as 1,3-butadiene, were detected with lower EFs. We demonstrated the unsuitability of a 'biofuel' containing fatty acid methyl esters for use with the wick heater, and that the accumulation of soot on the same heater, whatever the fuel, leads to a dramatic increase in the CO EF, up to 16 mg/g, which could be responsible for chronic and acute CO intoxications. Our results show that in spite of new technologies and emission standards for unvented kerosene space heaters, as well as for the fuels, the use of these heaters in indoor environments still leads to NO(x) levels in excess of current health recommendations. Whereas injection heaters generate more nitrogen oxides than wick heaters, prolonged use of the latter leads to a soot buildup, concomitant with high CO emissions, which could be responsible for acute and chronic intoxications. The use of a biofuel in a wick heater is also of concern. Maintenance of the heaters and adequate ventilation of the room during use of kerosene space heaters are therefore of prime importance to reduce personal exposure. © 2011 John Wiley & Sons A/S.

  5. Reviews on Current-limiting Protection Based on PTC Materials%基于PTC材料的限流保护研究现状

    Institute of Scientific and Technical Information of China (English)

    惠飞飞; 杨锋

    2015-01-01

    Aimed at the increasing of the short circuit current, the current limiting is an effective way to achieve the short-circuit protection. To adopt PTC components in the current-limiting protection is a new method in this area, which not only can be both recoverable and reusable, but also has the great potential of application in the area of the large current breaker. This paper mainly summarizes and compares existing methods for current-limiting protection. What's more, it systematically analyzes the problems in the research on PTC and listed on the types and applications of those PTC in being. More importantly, detailed analysis is made in this paper on the feasibility for the solution related to PTC's withstand voltage as well as its large current shock. Finally, the full text and get the drafting solution for the PTC's application in current limit is summarized.%短路电流不断增大,采用限流的方式进行短路保护是一种有效的保护方式.使用PTC元件进行限流保护是一种新型的保护方式,具有可恢复性和可重复使用的特点,且对于大电流的分断具有很大的应用潜力.该文对现有限流保护技术进行总结与比对,对PTC研究存在问题进行系统分析,阐述罗列现有PTC种类以及适用用途,并对其耐压大电流冲击方案进行可行性分析.最后对其全文进行总结,给出限流应用PTC拟解决方案.

  6. Use of a Combined SpO2/PtcCO2 Sensor in the Delivery Room

    Directory of Open Access Journals (Sweden)

    Costantino Romagnoli

    2012-08-01

    Full Text Available Arterial oxygen saturation (SaO2 and partial arterial pressure of carbon dioxide (PaCO2 are important respiratory parameters in critically ill neonates. A sensor combining a pulse oximeter with the Stow-Severinghaus electrode, required for the measurement of peripheral oxygen saturation (SpO2 and transcutaneous partial pressure of carbon dioxide (PtcCO2, respectively, has been recently used in neonatal clinical practice (TOSCA500ÒRadiometer. We evaluated TOSCA usability and reliability in the delivery room (DR, throughout three different periods, on term, late-preterm, and preterm neonates. During the first period (period A, 30 healthy term neonates were simultaneously monitored with both TOSCA and a MASIMO pulse oximeter. During the second period (period B, 10 healthy late-preterm neonates were monitored with both TOSCA and a transcutaneous device measuring PtcCO2 (TINAÒ TCM3, Radiometer. During the third period (period C, 15 preterm neonates were monitored with TOSCA and MASIMO after birth, during stabilization, and during transport to the neonatal intensive care unit (NICU. Blood gas analyses were performed to compare transcutaneous and blood gas values. TOSCA resulted easily and safely usable in the DR, allowing reliable noninvasive SaO2 estimation. Since PtcCO2 measurements with TOSCA required at least 10 min to be stable and reliable, this parameter was not useful during the early resuscitation immediately after birth. Moreover, PtcCO2 levels were less precise if compared to the conventional transcutaneous monitoring. However, PtcCO2 measurement by TOSCA was useful as trend-monitoring after stabilization and during transport to NICU.

  7. The Risk of Relapse in Papillary Thyroid Cancer (PTC) in the Context of BRAFV600E Mutation Status and Other Prognostic Factors

    Science.gov (United States)

    Czarniecka, Agnieszka; Kowal, Monika; Rusinek, Dagmara; Krajewska, Jolanta; Jarzab, Michal; Stobiecka, Ewa; Chmielik, Ewa; Zembala-Nozynska, Ewa; Poltorak, Stanislaw; Sacher, Aleksander; Maciejewski, Adam; Zebracka-Gala, Jadwiga; Lange, Dariusz; Oczko-Wojciechowska, Malgorzata; Handkiewicz-Junak, Daria; Jarzab, Barbara

    2015-01-01

    Introduction The risk of over-treatment in low-advanced PTC stages has prompted clinicians to search for new reliable prognostic factors. The presence of BRAF mutation, the most frequent molecular event in PTC, seems to be a good candidate. However, there is still lack of randomised trials and its significance has been proved by retrospective analyses, involving a large group of patients. The question arises whether this factor is useful in smaller populations, characterised for specialised centres. Thus, the aim of the study was to evaluate the use of BRAF mutation as a potential predictive marker in PTC patients. Material 233 PTC subjects treated between 2004-2006, were retrospectively analysed. Stage pT1 was diagnosed in 64.8% patients and lymph node metastases in 30.9%. Median follow-up was 7.5 years. BRAFV600E mutation was assessed postoperatively in all cases. Results BRAF V600E mutation was found in 54.5%. It was more frequent in patients > 45 years (p=0.0001), and associated with larger tumour size (p=0.004). Patients with tumours <= 10 mm were over-represented among BRAF negative population (p=0.03). No association between BRAF mutation and other clinicopathological factors was observed. BRAF status was associated neither with relapse nor with disease-free survival (DFS) (p=0.76). Nodal status, extrathyroidal invasion and tumour size significantly influenced DFS. Conclusion The risk of PTC recurrence is mainly related to the presence of lymph node metastases and extrathyroidal invasion, whereas no impact of BRAF V600E mutation has been demonstrated. PMID:26177218

  8. The Risk of Relapse in Papillary Thyroid Cancer (PTC in the Context of BRAFV600E Mutation Status and Other Prognostic Factors.

    Directory of Open Access Journals (Sweden)

    Agnieszka Czarniecka

    Full Text Available The risk of over-treatment in low-advanced PTC stages has prompted clinicians to search for new reliable prognostic factors. The presence of BRAF mutation, the most frequent molecular event in PTC, seems to be a good candidate. However, there is still lack of randomised trials and its significance has been proved by retrospective analyses, involving a large group of patients. The question arises whether this factor is useful in smaller populations, characterised for specialised centres. Thus, the aim of the study was to evaluate the use of BRAF mutation as a potential predictive marker in PTC patients.233 PTC subjects treated between 2004-2006, were retrospectively analysed. Stage pT1 was diagnosed in 64.8% patients and lymph node metastases in 30.9%. Median follow-up was 7.5 years. BRAFV600E mutation was assessed postoperatively in all cases.BRAF V600E mutation was found in 54.5%. It was more frequent in patients > 45 years (p=0.0001, and associated with larger tumour size (p=0.004. Patients with tumours <= 10 mm were over-represented among BRAF negative population (p=0.03. No association between BRAF mutation and other clinicopathological factors was observed. BRAF status was associated neither with relapse nor with disease-free survival (DFS (p=0.76. Nodal status, extrathyroidal invasion and tumour size significantly influenced DFS.The risk of PTC recurrence is mainly related to the presence of lymph node metastases and extrathyroidal invasion, whereas no impact of BRAF V600E mutation has been demonstrated.

  9. Building America Case Study: Simple Retrofit High-Efficiency Natural Gas Water Heater Field Test, Minneapolis, Minnesota

    Energy Technology Data Exchange (ETDEWEB)

    T. Schirber, B. Schoenbauer

    2017-06-01

    High-performance water heaters are typically more time consuming and costly to install in retrofit applications, making high-performance water heaters difficult to justify economically. However, recent advancements in high-performance water heaters have targeted the retrofit market, simplifying installations and reducing costs. Four high-efficiency natural gas water heaters designed specifically for retrofit applications were installed in single-family homes along with detailed monitoring systems to characterize their savings potential, their installed efficiencies, and their ability to meet household demands.

  10. Effect of Uniformly and Nonuniformly Coated Al2O3 Nanoparticles over Glass Tube Heater on Pool Boiling

    Directory of Open Access Journals (Sweden)

    Nitin Doifode

    2016-01-01

    Full Text Available Effect of uniformly and nonuniformly coated Al2O3 nanoparticles over plain glass tube heater on pool boiling heat transfer was studied experimentally. A borosilicate glass tube coated with Al2O3 nanoparticle was used as test heater. The boiling behaviour was studied by using high speed camera. Result obtained for pool boiling shows enhancement in heat transfer for nanoparticle coated surface heater and compared with plain glass tube heater. Also heat transfer coefficient for nonuniformly coated nanoparticles was studied and compared with uniformly coated and plain glass tube. Coating effect of nanoparticles over glass tube increases its surface roughness and thereby creates more nucleation sites.

  11. Development of an Accurate Feed-Forward Temperature Control Tankless Water Heater

    Energy Technology Data Exchange (ETDEWEB)

    David Yuill

    2008-06-30

    The following document is the final report for DE-FC26-05NT42327: Development of an Accurate Feed-Forward Temperature Control Tankless Water Heater. This work was carried out under a cooperative agreement from the Department of Energy's National Energy Technology Laboratory, with additional funding from Keltech, Inc. The objective of the project was to improve the temperature control performance of an electric tankless water heater (TWH). The reason for doing this is to minimize or eliminate one of the barriers to wider adoption of the TWH. TWH use less energy than typical (storage) water heaters because of the elimination of standby losses, so wider adoption will lead to reduced energy consumption. The project was carried out by Building Solutions, Inc. (BSI), a small business based in Omaha, Nebraska. BSI partnered with Keltech, Inc., a manufacturer of electric tankless water heaters based in Delton, Michigan. Additional work was carried out by the University of Nebraska and Mike Coward. A background study revealed several advantages and disadvantages to TWH. Besides using less energy than storage heaters, TWH provide an endless supply of hot water, have a longer life, use less floor space, can be used at point-of-use, and are suitable as boosters to enable alternative water heating technologies, such as solar or heat-pump water heaters. Their disadvantages are their higher cost, large instantaneous power requirement, and poor temperature control. A test method was developed to quantify performance under a representative range of disturbances to flow rate and inlet temperature. A device capable of conducting this test was designed and built. Some heaters currently on the market were tested, and were found to perform quite poorly. A new controller was designed using model predictive control (MPC). This control method required an accurate dynamic model to be created and required significant tuning to the controller before good control was achieved. The MPC

  12. Temperature optimization of an electric heater by emissivity variation of heating elements

    Directory of Open Access Journals (Sweden)

    Cédric Hemmer

    2014-11-01

    Full Text Available This note addresses an industrial application concerning the way to optimize the surface temperature of commercial electrical heater. The aim of this paper is to reduce the temperature on accessible surfaces and electrical heater in order to respect the European standards and quality criteria imposed by the manufacturer. This target must be achieved by changing only the emissivity distribution of the electric heater components. A numerical study of the natural convection flow coupled with radiation is carried out in a heated room with an electric heater. The physical model includes the transport equations of mass, momentum, energy and radiative transfer which are solved numerically. Thermo-physical properties of the fluid are assumed to be dependent of the temperature. The numerical simulations are carried out for a two-dimensional, steady and turbulent flow using the finite volume approach. Results showed the influence of emissivity distribution of the electric heater components. The reducing of the heating foil emissivity allowed to decrease the radiative contribution on the foil and its temperature.

  13. Accelerator Magnet Quench Heater Technology and Quality Control Tests for the LHC High Luminosity Upgrade

    CERN Document Server

    Meuter, Florian

    The High Luminosity upgrade of the Large Hadron Collider (HL-LHC) foresees the installation of new superconducting Nb3Sn magnets. For the protection of these magnets, quench heaters are placed on the magnet coils. The quench heater circuits are chemically etched from a stainless steel foil that is glued onto a flexible Polyimide film, using flexible printed circuit production technology. Approximately 500 quench heaters with a total length of about 3000 m are needed for the HL-LHC magnets. In order to keep the heater circuit electrical resistance in acceptable limits, an approximately 10 µm-thick Cu coating is applied onto the steel foil. The quality of this Cu coating has been found critical in the quench heater production. The work described in this thesis focuses on the characterisation of Cu coatings produced by electrolytic deposition, sputtering and electron beam evaporation. The quality of the Cu coatings from different manufacturers has been assessed for instance by ambient temperature electrical res...

  14. A modernized high-pressure heater protection system for nuclear and thermal power stations

    Science.gov (United States)

    Svyatkin, F. A.; Trifonov, N. N.; Ukhanova, M. G.; Tren'kin, V. B.; Koltunov, V. A.; Borovkov, A. I.; Klyavin, O. I.

    2013-09-01

    Experience gained from operation of high-pressure heaters and their protection systems serving to exclude ingress of water into the turbine is analyzed. A formula for determining the time for which the high-pressure heater shell steam space is filled when a rupture of tubes in it occurs is analyzed, and conclusions regarding the high-pressure heater design most advisable from this point of view are drawn. A typical structure of protection from increase of water level in the shell of high-pressure heaters used in domestically produced turbines for thermal and nuclear power stations is described, and examples illustrating this structure are given. Shortcomings of components used in the existing protection systems that may lead to an accident at the power station are considered. A modernized protection system intended to exclude the above-mentioned shortcomings was developed at the NPO Central Boiler-Turbine Institute and ZioMAR Engineering Company, and the design solutions used in this system are described. A mathematical model of the protection system's main elements (the admission and check valves) has been developed with participation of specialists from the St. Petersburg Polytechnic University, and a numerical investigation of these elements is carried out. The design version of surge tanks developed by specialists of the Central Boiler-Turbine Institute for excluding false operation of the high-pressure heater protection system is proposed.

  15. Development of the robot for pressurizer electric heater inspection and repairing

    Energy Technology Data Exchange (ETDEWEB)

    Jung, Seung Ho; Kim, Seung Ho; Su, Yong Chil

    1998-01-01

    In this study a robot system has been developed for inspection and maintenance of the pressurizer and the rod heater. The developed robot system consists of four parts: two links, a support frame, a movable gripper, and a controller box. The robot is attached on the support frame, which is attached at the man-way flange of the pressurizer such that the robot is positioned inside pressurizer. To access arbitrary heater, at first two links horizontally rotate, and then the gripper suspended by two steel wires moves up and down by turing wire drum because the rod heaters are located about 8 meters under the robot and are arranged in two circular rows. The robot must be designed under several constraint such as its weight and collision with pressurizer wall or spray nozzle because the robot is positioned and moves inside the pressurizer. To verify that the designed robot is free from collision during installation procedure and it can access any desired rod heater, it is simulated by 3-dimensional graphic software (RobCAD). For evaluating stress of the support frame finite element analysis is performed by using the ANSYS code. For gripping the rod heater the passive self-locking mechanism is adopted, which is made up three balls and springs. Because the mechanism is very simple, it is very hardly defected than that adopted motor. (author). 11 refs., 8 tabs., 13 figs

  16. The effects of operating conditions on emissions from masonry heaters and sauna stoves

    Energy Technology Data Exchange (ETDEWEB)

    Tissari, Jarkko; Hytoenen, Kati; Sippula, Olli [Fine Particle and Aerosol Technology Laboratory, University of Kuopio, PO Box 1627, 70211 Kuopio (Finland); Jokiniemi, Jorma [Fine Particle and Aerosol Technology Laboratory, University of Kuopio, PO Box 1627, 70211 Kuopio (Finland)]|[VTT, Technical Research Centre of Finland, Fine Particles, PO Box 1000, 02044 VTT, Espoo (Finland)

    2009-03-15

    Emissions from masonry heaters and sauna stoves were studied. In the sauna stove the production of organic gaseous carbon (OGC) at 10 gC kg{sup -1} (per kilogram of fuel), carbon monoxide (CO) at 55 g kg{sup -1}, fine particle mass (PM{sub 1}) at 5 g kg{sup -1} and number emissions (N) at 1.8 x 10{sup 15} kg{sup -1} was higher than in other measured appliances. In a modern technology masonry heater with a unique grate, the emissions were very low: 0.4 gC kg{sup -1} OGC, 14 g kg{sup -1} CO and 0.7 g kg{sup -1} PM{sub 1}. Conventional masonry heaters, using small logs, clearly produced higher emissions when compared to using large logs. Doubling the fuel load caused emission factors to increase by up to 4- times (OGC), except for the number emission, which decreased from 4.0 x 10{sup 14} to 2.0 x 10{sup 14} kg{sup -1}. From the conventional masonry heater 90% of the PM was emitted during the firing phase. Its combustion process is different to that in stoves or conventional open fireplaces. The insufficient supply of air, due to too fast pyrolysis, and increased ash release, due to the high combustion temperature, are the main parameters which cause high particle and gas emissions in masonry heaters and sauna stoves. (author)

  17. Accelerated Life Structural Benchmark Testing for a Stirling Convertor Heater Head

    Science.gov (United States)

    Krause, David L.; Kantzos, Pete T.

    2006-01-01

    For proposed long-duration NASA Space Science missions, the Department of Energy, Lockheed Martin, Infinia Corporation, and NASA Glenn Research Center are developing a high-efficiency, 110 W Stirling Radioisotope Generator (SRG110). A structurally significant limit state for the SRG110 heater head component is creep deformation induced at high material temperature and low stress level. Conventional investigations of creep behavior adequately rely on experimental results from uniaxial creep specimens, and a wealth of creep data is available for the Inconel 718 material of construction. However, the specified atypical thin heater head material is fine-grained with a heat treatment that limits precipitate growth, and little creep property data for this microstructure is available in the literature. In addition, the geometry and loading conditions apply a multiaxial stress state on the component, far from the conditions of uniaxial testing. For these reasons, an extensive experimental investigation is ongoing to aid in accurately assessing the durability of the SRG110 heater head. This investigation supplements uniaxial creep testing with pneumatic testing of heater head-like pressure vessels at design temperature with stress levels ranging from approximately the design stress to several times that. This paper presents experimental results, post-test microstructural analyses, and conclusions for four higher-stress, accelerated life tests. Analysts are using these results to calibrate deterministic and probabilistic analytical creep models of the SRG110 heater head.

  18. Experimental investigation of three different solar air heaters: Energy and exergy analyses

    Energy Technology Data Exchange (ETDEWEB)

    Alta, Deniz; Ertekin, C.; Yaldiz, Osman [Department of Farm Machinery, Faculty of Agricultural Engineering, Akdeniz University, 07059 Antalya (Turkey); Bilgili, Emin [Cukurova Agricultural Research Institute, Adana (Turkey)

    2010-10-15

    The present study aims to compare three different types of designed flat-plate solar air heaters, two having fins (Type II and Type III) and the other without fins (Type I), one of the heater with a fin had single glass cover (Type III) and the others had double glass covers (Type I and Type II). The energy and exergy output rates of the solar air heaters were evaluated for various air flow rates (25, 50 and 100 m{sup 3}/m{sup 2} h), tilt angle (0 , 15 and 30 ) and temperature conditions versus time. Based on the energy and exergy output rates, heater with double glass covers and fins (Type II) is more effective and the difference between the input and output air temperature is higher than of the others. Besides, it is found that the circulation time of air inside the heater played a role more important than of the number of transparent sheet. Lower air flow rates should be preferred in the applications of which temperature differences is more important. (author)

  19. Building America Case Study: Simple Retrofit High-Efficiency Natural Gas Water Heater Field Test, Minneapolis, Minnesota

    Energy Technology Data Exchange (ETDEWEB)

    2017-06-12

    High performance water heaters are typically more time consuming and costly to install in retrofit applications, making high performance water heaters difficult to justify economically. However, recent advancements in high performance water heaters have targeted the retrofit market, simplifying installations and reducing costs. Four high efficiency natural gas water heaters designed specifically for retrofit applications were installed in single-family homes along with detailed monitoring systems to characterize their savings potential, their installed efficiencies, and their ability to meet household demands. The water heaters tested for this project were designed to improve the cost-effectiveness and increase market penetration of high efficiency water heaters in the residential retrofit market. The retrofit high efficiency water heaters achieved their goal of reducing costs, maintaining savings potential and installed efficiency of other high efficiency water heaters, and meeting the necessary capacity in order to improve cost-effectiveness. However, the improvements were not sufficient to achieve simple paybacks of less than ten years for the incremental cost compared to a minimum efficiency heater. Significant changes would be necessary to reduce the simple payback to six years or less. Annual energy savings in the range of $200 would also reduce paybacks to less than six years. These energy savings would require either significantly higher fuel costs (greater than $1.50 per therm) or very high usage (around 120 gallons per day). For current incremental costs, the water heater efficiency would need to be similar to that of a heat pump water heater to deliver a six year payback.

  20. Assessment of Performance Characteristic of Solar Air Heater with Assorted Geometries - A Review

    Directory of Open Access Journals (Sweden)

    Alok Kumar Rohit

    2016-01-01

    Full Text Available Artificial roughness is an efficient way for increasing the heat transfer rate in solar air heater with the corresponding improvement in its thermal performance. A viscous sub-layer is responsible for the low heat transfer coefficient between absorber plate and flowing air. Repeated ribs in form of artificial roughness are an effective way to increase the heat transfer rate and improving the performance of solar air heater. Artificial roughness of the absorber plate is much economical and effective way to improve the thermal performance of solar air heater. Several investigators have done various investigations to improve heat transfer coefficient with little penalty of friction factor. They have also developed different correlation for heat transfer coefficient and friction factor. The correlations developed for heat transfer and friction factor by various investigators have been reviewed and presented.

  1. A novel domestic electric water heater model for a multi-objective demand side management program

    Energy Technology Data Exchange (ETDEWEB)

    Paull, Liam; Li, Howard; Chang, Liuchen [University of New Brunswick, Department of Electrical Engineering, Fredericton, NB (Canada)

    2010-12-15

    This paper presents a novel domestic hot water heater model to be used in a multi-objective demand side management program. The model incorporates both the thermal losses and the water usage to determine the temperature of the water in the tank. Water heater loads are extracted from household load data and then used to determine the household water usage patterns. The benefits of the model are: (1) the on/off state of the water heater and temperature of the water in the tank can be accurately predicted, and (2) it enables the development of water usage profiles so that users can be classified based on usage behaviour. As a result, the amount of ancillary services and peak shaving that can be achieved are accurately predictable and can be maximized without adversely affecting users. (author)

  2. Development of Industrially Produced Composite Quench Heaters for the LHC Superconducting Lattice Magnets

    CERN Document Server

    Szeless, Balázs; Calvone, F

    1996-01-01

    The quench heaters are vital elements for the protection of the LHC superconducting lattice magnets in the case of resistive transitions of the conductor. The basic concept of magnet protection and technical solutions are briefly presented. The quench heater consists of partially copper clad stainless steel strips sandwiched in between electric insulating carrier foils with electrical and mechanical properties such as to withstand high voltages, low temperatures, pressures and ionizing radiation. Testing of some commercial available electric insulation foils, polyimide (PI), polyetheretherketon (PEEK) and polyarylate (PA) and combinations of adhesive systems which are suitable for industrial processing are described. Possible industrial methods for series production for some 80 km of these composite quench heaters are indicated.

  3. Building America Case Study: Assessment of a Hybrid Retrofit Gas Water Heater

    Energy Technology Data Exchange (ETDEWEB)

    M. Hoeschele, E. Weitzel, C. Backman

    2017-06-01

    This project completed a modeling evaluation of a hybrid gas water heater that combines a reduced capacity tankless unit with a downsized storage tank. This product would meet a significant market need by providing a higher efficiency gas water heater solution for retrofit applications while maintaining compatibility with the half-inch gas lines and standard B vents found in most homes. The TRNSYS simulation tool was used to model a base case 0.60 EF atmospheric gas storage water, a 0.82 EF non-condensing gas tankless water heater, an existing (high capacity) hybrid unit on the market, and an alternative hybrid unit with lower storage volume and reduced gas input requirements.

  4. Preliminary Modeling, Testing, and Analysis of a Gas Tankless Water Heater: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Burch, J.; Hoeschele, M.; Springer, D.; Rudd, A.

    2008-05-01

    Today's gas tankless water heaters offer significant energy savings over conventional gas storage tank water heaters, but savings depends on the draw pattern. A one-node model incorporating heat exchanger mass is used to address this and other issues. Key model parameters are determined from least-squares regression on short-term data, including burner efficiency, thermal capacitance, and thermal loss coefficient. The calibrated model agrees with data to ~5% on Qgas, with temperature RMS deviation of ~4..deg..C. Efficiency with a standard realistic draw is 71%, compared to 81% predicted from standard energy-factors. Adding a small tank controlled by the tankless heater solves issues of oscillations with solar pre-heat, low-flow and hot-water-delay issues. Future work includes model refinements and developing optimal data protocols for model parameter extraction.

  5. An Experimental and Analytical Investigation of Stirling Space Power Converter Heater Head

    Science.gov (United States)

    Abdul-Aziz, Ali; Bartolotta, Paul; Tong, Mike; Allen, Gorden

    1995-01-01

    NASA has identified the Stirling power converter as a prime candidate for the next generation power system for space applications requiring 60000 hr of operation. To meet this long-term goal, several critical components of the power converter have been analyzed using advanced structural assessment methods. Perhaps the most critical component, because of its geometric complexity and operating environment, is the power converter's heater head. This report describes the life assessment of the heater head which includes the characterization of a viscoplastic material model, the thermal and structural analyses of the heater head, and the interpolation of fatigue and creep test results of a nickel-base superalloy, Udimet 720 LI (Low Inclusions), at several elevated temperatures for life prediction purposes.

  6. Study on Ag mesh/conductive oxide hybrid transparent electrode for film heaters

    Science.gov (United States)

    Kwon, Namyong; Kim, Kyohyeok; Heo, Jinhee; Yi, Insook; Chung, Ilsub

    2014-07-01

    Ag mesh-indium tin oxide (ITO) hybrid transparent conductive films were fabricated and evaluated for use in film heaters. PS monolayer templates were prepared using highly mono-dispersed PS spheres (11.2 μm) obtained by a filtering process with micro-sieves. At first, three Ag meshes with different sheet resistances (20, 100, and 300 Ω sq-1) and transmittances (70, 73, and 76%) were evaluated for film heaters in terms of voltage and long-term stability. Subsequently, in an effort to obtain better transmittance, Ag mesh-ITO hybrid heaters were fabricated utilizing finite ITO depositions. At the optimised ITO thickness (15 nm), the sheet resistance and the transmittance were 300 Ω sq-1 and 88%, respectively, which indicates that this material is a good potential candidate for an efficient defroster in vehicles.

  7. Performance estimation of artificially roughened solar air heater duct provided with continuous ribs

    Directory of Open Access Journals (Sweden)

    Mridul Sharma, Varun

    2010-09-01

    Full Text Available The use of an artificial roughness on a surface is an effective technique to enhance the rate of heat transfer to fluid flow in the duct of a solar air heater. This paper presents a comparison of exergetic performance of solar air heaters having different types of geometry of roughness elements (continuous ribs on the absorber plate. The exergy efficiency has been computed by using the correlations for heat transfer and friction factor developed by various investigators within the investigated range of operating and system parameters. The exergy efficiency based criterion shows the better results at lower value of Re. There is not a single roughness geometry which gives best exergetic performance for whole range of Reynolds number. Solar air heater having rib-grooved and arc shaped wire as artificial roughness is found to have better exergy efficiency in the lower range of Reynolds number. However, smooth duct is found suitable in the higher range of Reynolds number.

  8. The benefit of solid oxide fuel cells with integrated air pre-heater

    Energy Technology Data Exchange (ETDEWEB)

    Costamagna, P. [Univ. degli Studi di Genova, Fac. di Ingegneria, ISTIC, Inst. di Ingegneria Chimica e di Processo `G.B. Bonino`, Genova (Italy)

    1997-11-01

    A new design has recently been proposed in the field of solid oxide fuel cells, consisting of a traditional electrochemical cell integrated with a pre-heater. In this paper a simulation model for the rectangular planar solid oxide fuel cell with integrated air pre-heater is presented. A two-dimensional stack simulation is presented as well, one axis coincides with the fuel flow direction, the other with the stack height. Local quantities such as current density, gas and solid temperatures are reported and cell characteristics predicted. In a parameter study, effects of oxygen utilisation and heat-transfer conditions in the pre-heater on the local temperature distribution of the solid structure are considered. As a result, the benefit of the new cell design becomes evident when low air flow rates are applied. A further advantage associated with the reduced flow rate is the low air temperature at the inlet. (orig.)

  9. Active compensation of wavefront aberrations by controllable heating of lens with electric film heater matrix.

    Science.gov (United States)

    Chen, Hua; Hou, Lv; Zhou, Xinglin

    2016-08-20

    We present a new apparatus for active compensation of wavefront aberrations by controllable heating of a lens using a film heater matrix. The annular electric film heater matrix, comprising 24 individual heaters, is attached to the periphery of a lens. Utilizing the linear superposition, and wavefront change proportional to the heating energy properties induced by heating, a controllable wavefront can be defined by solving a linear function. The two properties of wavefront change of a lens have been confirmed through a specially designed experiment. The feasibility of the compensation method is validated by compensating the wavefront of a plate lens. The results show that the wavefront of the lens changes from 12.52 to 2.95 nm rms after compensation. With a more precise electric controlling board, better results could be achieved.

  10. Effective efficiency prediction for discrete type of ribs used in solar air heaters

    Directory of Open Access Journals (Sweden)

    Muneesh Sethi, Mridul Sharma, Varun

    2010-03-01

    Full Text Available The use of an artificial roughness on a surface is an effective technique to enhance the heat transfer from the collector plate to the air in a solar air heater duct. However, artificial roughness leads to even more fluid pressure thereby increasing the pumping power. Number of geometries of roughness elements has been investigated on the heat transfer and friction characteristics of solar air heater ducts. This paper presents a comparison of effective efficiency of solar air heaters having different types of geometry of roughness elements (discrete ribs on the absorber plate. The effective efficiency has been computed by using the correlations for heat transfer and friction factor developed by various investigators within the investigated range of operating and system parameters.

  11. Effect of Ti addition to Pt/C catalyst on methanol electro-oxidation and oxygen electro-reduction reactions

    Energy Technology Data Exchange (ETDEWEB)

    Jeon, Min Ku; McGinn, Paul J. [Department of Chemical and Biomolecular Eng., University of Notre Dame, 178 Fitzpatrick, Notre Dame, IN 46556 (United States)

    2010-05-01

    Carbon supported binary Pt-Ti alloys were investigated for application in methanol electro-oxidation (MOR) and oxygen electro-reduction reactions (ORR). Various compositions of Pt{sub 100-x}Ti{sub x}/C (x = 0, 25, 50, and 75) catalysts were synthesized by sequential impregnation of Pt and Ti followed by annealing at 900 C for 30 min under H{sub 2}/Ar flow. X-ray diffraction results showed formation of the Pt{sub 3}Ti intermetallic phase in Pt{sub 50}Ti{sub 50} and Pt{sub 25}Ti{sub 75} catalysts after annealing at 900 C. The Pt{sub 50}Ti{sub 50}/C-900 and Pt{sub 25}Ti{sub 75}/C-900 catalysts (the '-900' designation indicates the catalyst was annealed at 900 C) exhibited 103% (87.4mA m g{sub Pt}{sup -1}) and 198% (128mA m g{sub Pt}{sup -1}) higher MOR activity, respectively, than in the Pt/C-900 catalyst (43.0mA m g{sub Pt}{sup -1}) at 0.7 V (vs. reversible hydrogen electrode (RHE)). These two catalysts also showed high ORR activity. From a specific activity basis, the Pt{sub 50}Ti{sub 50}/C-900 and Pt{sub 25}Ti{sub 75}/C-900 catalysts exhibited 32.3and30.2{mu} A c m{sub Pt}{sup -2}, respectively, which were 171 and 154% higher than the 11.9{mu} A c m{sub Pt}{sup -2} value of the Pt/C catalyst at 0.8 V (vs. RHE). Methanol-tolerant ORR activity was also investigated, but in the presence of methanol, the Pt{sub 50}Ti{sub 50}/C-900 and Pt{sub 25}Ti{sub 75}/C-900 catalysts both exhibited poor ORR activity. (author)

  12. Detection of PAX8/PPARG and RET/PTC rearrangements is feasible in routine air-dried fine needle aspiration smears.

    Science.gov (United States)

    Ferraz, Carolina; Rehfeld, Christian; Krogdahl, Annelise; Precht Jensen, Eva Magrethe; Bösenberg, Eileen; Narz, Frank; Hegedüs, Laszlo; Paschke, Ralf; Eszlinger, Markus

    2012-10-01

    The diagnostic limitations of fine needle aspiration (FNA), like the indeterminate category, can be partially overcome by molecular analysis. As PAX8/PPARG and RET/PTC rearrangements have been detected in follicular thyroid carcinomas (FTCs) and papillary thyroid carcinomas (PTCs), their detection in FNA smears could improve the FNA diagnosis. To date, these rearrangements have never been analyzed in routine air-dried FNA smears, but only in frozen tissue, formalin-fixed paraffin-embedded (FFPE) tissue, and in fresh FNA material. Fixed routine air-dried FNA samples have hitherto been judged as generally not suitable for testing these rearrangements in a clinical setting. Therefore, the objective of the present study was to investigate the feasibility of extracting RNA from routine air-dried FNA smears for the detection of these rearrangements with real-time polymerase chain reaction (RT-PCR). A new method for RNA extraction from routine air-dried FNA smears was established, which allowed analysis for the presence of four variants of PAX8/PPARG and RET/PTC 1 and RET/PTC 3, which were analyzed in 106 routine FNA smears and the corresponding surgically obtained FFPE tissues using real-time quantitative PCR (RT-qPCR). To assess RNA quality, an intron-spanning PAX8 cDNA was amplified. Acceptable RNA quality was obtained from 95% of the FNA samples and 92% of the FFPE samples. PAX8/PPARG was detected in 4 of 96 FFPEs and in 6 of 96 FNAs. PAX8/PPARG was present in 4 of 10 FTCs and in 3 of 42 follicular adenomas (FAs). Similarly, RET/PTC was found in 3 of 96 FFPEs and in 4 of 96 FNAs. Two of 21 PTC samples and 3 of 42 FA samples carried this rearrangement. These data are the first to show the feasibility of extracting RNA from routine air-dried FNA smears for the detection of PAX8/PPARG and RET/PTC rearrangements with RT-qPCR. These promising methodological advances, if confirmed in larger series of FNA and FFPE samples, may lead to the introduction of molecular analysis

  13. Design of high-pressure direct contact heater for promising power supply units: Experimental substantiation

    Science.gov (United States)

    Somova, E. V.; Shvarts, A. L.; Turkin, A. V.

    2016-11-01

    The results of experimental studies of superheated steam condensation on feed water jets in a highpressure, direct-contact heat exchanger are presented. Direct contact feed water heater (DCFWH) can be used in a dual-flow diagram of a steam-power unit with ultrasupercritical steam parameters (35 MPa, 700/720°C). The direct contact feed water heater is included in the flow diagram of the II circuit in a promising power unit; it provides feed water heating to 340°C in all maintenance and emergency operation modes of the unit. The reliability of the high-pressure direct contact heater operation in this flow diagram is of major importance in relation to the danger of lead solidification in the tube space of the steam generator. Technical requirements to the design of the high-pressure direct contact heater for increasing the heat exchange efficiency are formulated based on the results of earlier studies with steam-water mixture as the heating medium. The results of studies of superheated steam condensation on jets presented in this study testify that feed water is additionally heated to the required temperature at the output of the installation. The influence of initial feed water parameters (outflow velocity and temperature) on the jet heating length is elucidated. The numerical approximation of the experimental data for determination of the jet heating length in the nominal and partial power unit loads is obtained. The results of the calculations are used to simplify the design of the water-supplying element for the direct contact feed water heater. The proposed design of direct contact feed water heater is characterized by simplicity and low metal intensity, which provides the installation reliability at the considered pressure level due to the minimum number of structural elements.

  14. MATHEMATICAL AND INFORMATION SUPPORT FOR CALCULATION AND DESIGN OF TUBE GAS HEATERS LOCATED IN STRUCTURES

    Directory of Open Access Journals (Sweden)

    CHORNOMORETS H. Y.

    2016-02-01

    Full Text Available Raising of problem. For the design and construction of tube gas heaters in building structures to need solve the problems of analysis and synthesis of such heating system. The mathematical model of this system is consists of: mathematical model of the tube gas heater, mathematical model of heat distribution in the building structure and corresponding boundary conditions. To solve the tasks of analysis and synthesis must be appropriate mathematical and information support. Purpose. The purpose of this paper is to describe the developed mathematical and information support that solve the problems of analysis and synthesis of heating systems with gas tube heaters, located in building constructions.Conclusion. Mathematical support includes the development of algorithms and software for the numerical solution of problems analysis and synthesis heating system. Information support includes all the necessary parameters characterizing the thermal properties of materials which used in the heating system, and the parameters characterizing the heat exchange between the coolant and components of the heating system. It was developed algorithms for solving problems of analysis and synthesis heating system with tube gas heater located in structures to use evolutionary search algorithm and software. It was made experimental study and was obtained results allow to calculate the heat transfer from the gas-air mixture to the boundary surface of the building structure. This results and computation will provide full information support for solving problems of analysis and synthesis of the heating system. Was developed mathematical and software support, which allows to solve the problems of analysis and synthesis heating systems with gas tube heaters, located in building structures. Tube gas heaters located in the building structures allows with small capital expenditures to provide space heating. Is necessary to solve the problems of analysis (calculation and

  15. Rate of heat transfer in polypropylene tubes in solar water heaters

    Energy Technology Data Exchange (ETDEWEB)

    Razavi, J.; Mahmoodi, M. [Sharif University of Technology, Tehran (Iran). Chemical Engineering Dept.; Riazi, M.R. [Kuwait Univ., Safat (Kuwait). Chemical Engineering Dept.

    2003-06-01

    A heat transfer rate was determined for polypropylene tubes in solar water heaters for the Reynolds number range 800-5600. Experiments were conducted in ambient temperatures of 34 to 37 {sup o}C. Data were correlated in the form of Nusselt numbers as: Nu=0.0015 Re{sup 0.75}Pr{sup 1/3} with correlation coefficient of 0.95. Such data can be used to predict heat transfer rates in a polypropylene solar heater in Tehran where the experiments were performed. An application of the results is shown in an example. (author)

  16. Experimental comparison of alternative convection suppression arrangements for concentrating integral collector storage solar water heaters

    Energy Technology Data Exchange (ETDEWEB)

    Smyth, M.; McGarrigle, P.; Eames, P.C. [Ulster Univ., School of the Built Environment, Newtownabbey, Northern Ireland (United Kingdom); Norton, B. [Dublin Inst. of Technology, Dublin (Ireland)

    2005-02-01

    An experimental investigation of an inverted absorber integrated collector storage solar water heater mounted in the tertiary cavity of a compound parabolic concentrator with a secondary cylindrical reflector has been performed under simulated solar conditions. The solar water heaters performance was determined with the aperture parallel to the simulator for a range of transparent baffles positioned at different locations within the collector cavity. Results indicate that glass baffles located at the upper portion of the exit aperture of the CPC can reduce thermal losses through convection suppression without significantly increasing optical losses. (Author)

  17. Boiling Heat Transfer Measurements on Highly Conductive Surfaces Using Microscale Heater and Temperature Arrays

    Science.gov (United States)

    Kim, J.; Bae, S. W.; Whitten, M. W.; Mullen, J. D.; Quine, R. W.; Kalkur, T. S.

    1999-01-01

    Two systems have been developed to study boiling heat transfer on the microscale. The first system utilizes a 32 x 32 array of diodes to measure the local temperature fluctuations during boiling on a silicon wafer heated from below. The second system utilizes an array of 96 microscale heaters each maintained at constant surface temperature using electronic feedback loops. The power required to keep each heater at constant temperature is measured, enabling the local heat transfer coefficient to be determined. Both of these systems as well as some preliminary results are discussed.

  18. Enhanced Heat Transfer Tubes for Absorber of Absorption Chiller/Heater

    Science.gov (United States)

    Furukawa, Masahiro; Sasaki, Naoe; Kaneko, Toshiyuki; Nosetani, Tadashi

    For the purpose of development of high performance absorption chiller/heater utilizing lithium bromide aqueous solution as working fluid, it is the most effective to improve the performance of absorber with the largest heat transfer area of the four heat exchangers. This paper introduces two kinds of double fluted tubes for the absorber of absorption chiller/heater. Arm tube and floral tube have about 40% higter heat transfer performance than the plain tube conventionally used in absorber. The former is manufactured by double drawbench process, while the latter by single drawbench process. Therefore, floral tube is expected to realize both high heat transfer perfoemance and low cost.

  19. Single-structure heater and temperature sensor using a p-type polycrystalline diamond resistor

    Energy Technology Data Exchange (ETDEWEB)

    Yang, G.S.; Aslam, D.M. [Michigan State Univ., East Lansing, MI (United States). Dept. of Electrical Engineering

    1996-05-01

    Heat generation and temperature sensing are required for heating applications and for liquid level sensors, mass flow meters, and vacuum and pressure gauges which are based on variations of heat dissipation. Heat generation and temperature sensing are reported in a single p-type diamond resistor fabricated on an oxidized Si substrate using diamond film technology compatible with integrated circuit (IC) processing. Power densities in excess of 600 W/in.{sup 2} are observed for the heaters. The temperature response of the sensor is characterized in the temperature range of 300--725 K. Such a diamond heater/sensor device is reported for the first time.

  20. Particle impaction efficiency and size distribution in a MSWI super heater tube bundle

    CERN Document Server

    Haugen, Nils Erland L; Bugge, Mette; Warnecke, Ragnar; Weghaus, Martin

    2010-01-01

    Particle impaction in the super heater geometry found in the municipal solid waste incinerator (MSWI) of GKS in Schweinfurt, Germany, has been investigated. By using direct numerical simulations for the fluid flow, inertial particles coupled to the fluid through the classical Stokes' drag law have been tracked. Focus has been on the effect of flow velocity, and it is shown that decreasing the flow velocity will drastically decrease the impaction efficiency for some particle radii. Finally particle size distribution measurements are presented and used to find quantitative mass fluxes both on the front and the back side of the tubes in the super heater tube bundle.