WorldWideScience

Sample records for ptba holds promise

  1. Stem Cells Hold Promise, Peril in Treating Seniors' Eye Disease

    Science.gov (United States)

    ... page: https://medlineplus.gov/news/fullstory_164099.html Stem Cells Hold Promise, Peril in Treating Seniors' Eye Disease ... 15, 2017 WEDNESDAY, March 15, 2017 (HealthDay News) -- Stem cells may offer new hope for people losing their ...

  2. Proton microbeam irradiation effects on PtBA polymer

    Indian Academy of Sciences (India)

    J Kamila; S Roy; K Bhattacharjee; B Rout; B N Dev; R Guico; J Wang; A W Haberl; P Ayyub; P V Satyam

    2006-04-01

    Proton beam lithography has made it possible to make various types of 3D-structures in polymers. Usually PMMA, SU-8, PS polymers have been used as resist materials for lithographic purpose. Microbeam irradiation effects on poly-tert-butyl-acrylate (PtBA) polymer using 2.0 MeV proton microbeam are reported. Preliminary results on pattern formation on PtBA are carried out as a function of fluence. After writing the pattern, a thin layer of Ge is deposited. Distribution of Ge in pristine and ion beam patterned surface of PtBA polymer is studied using the optical and secondary electron microscopic experimental methods.

  3. Study Finds Ebola Treatment ZMapp Holds Promise, Although Results Not Definitive

    Science.gov (United States)

    ... News Release Thursday, October 13, 2016 Study finds Ebola treatment ZMapp holds promise, although results not definitive ... emergency. A clinical trial to evaluate the experimental Ebola treatment ZMapp found it to be safe and ...

  4. Miniaturized bacterial biosensor system for arsenic detection holds great promise for making integrated measurement device.

    Science.gov (United States)

    Buffi, Nina; Merulla, Davide; Beutier, Julien; Barbaud, Fanny; Beggah, Siham; van Lintel, Harald; Renaud, Philippe; van der Meer, Jan Roelof

    2011-01-01

    Combining bacterial bioreporters with microfluidics systems holds great promise for in-field detection of chemical or toxicity targets. Recently we showed how Escherichia coli cells engineered to produce a variant of green fluorescent protein after contact to arsenite and arsenate can be encapsulated in agarose beads and incorporated into a microfluidic chip to create a device for in-field detection of arsenic, a contaminant of well known toxicity and carcinogenicity in potable water both in industrialized and developing countries. Cell-beads stored in the microfluidics chip at -20°C retained inducibility up to one month and we were able to reproducibly discriminate concentrations of 10 and 50 μg arsenite per L (the drinking water standards for European countries and the United States, and for the developing countries, respectively) from the blank in less than 200 minutes. We discuss here the reasons for decreasing bioreporter signal development upon increased storage of cell beads but also show how this decrease can be reduced, leading to a faster detection and a longer lifetime of the device.

  5. Cloud Coaching: Web-Based Learning Holds Promise, Especially for Districts with Limited Resources

    Science.gov (United States)

    Matsumura, Lindsay Clare; Bickel, Donna DiPrima; Zook-Howell, Dena; Correnti, Richard; Walsh, Marguerite

    2016-01-01

    Web-based coaching shows significant promise for linking teachers to highly expert practitioners. This is particularly important in districts that cannot afford to hire full-time school-based coaches or to train and support coaches to be experts in all content areas. While web-based teacher professional development shows a great deal of potential…

  6. Blocking TRPA1 in Respiratory Disorders: Does It Hold a Promise?

    Directory of Open Access Journals (Sweden)

    Indranil Mukhopadhyay

    2016-11-01

    Full Text Available Transient Receptor Potential Ankyrin 1 (TRPA1 ion channel is expressed abundantly on the C fibers that innervate almost entire respiratory tract starting from oral cavity and oropharynx, conducting airways in the trachea, bronchi, terminal bronchioles, respiratory bronchioles and upto alveolar ducts and alveoli. Functional presence of TRPA1 on non-neuronal cells got recognized recently. TRPA1 plays a well-recognized role of “chemosensor”, detecting presence of exogenous irritants and endogenous pro-inflammatory mediators that are implicated in airway inflammation and sensory symptoms like chronic cough, asthma, chronic obstructive pulmonary disease (COPD, allergic rhinitis and cystic fibrosis. TRPA1 can remain activated chronically due to elevated levels and continued presence of such endogenous ligands and pro-inflammatory mediators. Several selective TRPA1 antagonists have been tested in animal models of respiratory disease and their performance is very promising. Although there is no TRPA1 antagonist in advanced clinical trials or approved on market yet to treat respiratory diseases, however, limited but promising evidences available so far indicate likelihood that targeting TRPA1 may present a new therapy in treatment of respiratory diseases in near future. This review will focus on in vitro, animal and human evidences that strengthen the proposed role of TRPA1 in modulation of specific airway sensory responses and also on preclinical and clinical progress of selected TRPA1 antagonists.

  7. Does a sorghum-cowpea composite porridge hold promise for contributing to alleviating oxidative stress?

    Science.gov (United States)

    Apea-Bah, Franklin B; Minnaar, Amanda; Bester, Megan J; Duodu, Kwaku G

    2014-08-15

    The effect of compositing red non-tannin sorghum with cream-coloured cowpea and porridge preparation on phenolic profile and radical scavenging activity was studied. A maize-soybean composite porridge representing a similar product on the South African market was used as reference sample. UPLC-QToF-MS-ESI was used to determine phenolic composition of the grain flours, their composites and porridges. Total phenolic content was determined using Folin-Ciocalteu method while radical scavenging activity was determined using the ABTS, DPPH and NO radical scavenging assays. Four benzoic acid derivatives and five cinnamic acid derivatives were identified in the samples. The predominant flavonoid subclasses identified in sorghum were flavan-3-ols, flavanones and flavones while cowpea had mainly flavan-3-ols and flavonols with soybean having mainly isoflavones. Compositing the cereals with legumes significantly (pporridge showed better promise in contributing to alleviating radical induced oxidative stress than maize-soybean composite porridge.

  8. Do biological-based strategies hold promise to biofouling control in MBRs?

    KAUST Repository

    Malaeb, Lilian

    2013-10-01

    Biofouling in membrane bioreactors (MBRs) remains a primary challenge for their wider application, despite the growing acceptance of MBRs worldwide. Research studies on membrane fouling are extensive in the literature, with more than 200 publications on MBR fouling in the last 3 years; yet, improvements in practice on biofouling control and management have been remarkably slow. Commonly applied cleaning methods are only partially effective and membrane replacement often becomes frequent. The reason for the slow advancement in successful control of biofouling is largely attributed to the complex interactions of involved biological compounds and the lack of representative-for-practice experimental approaches to evaluate potential effective control strategies. Biofouling is driven by microorganisms and their associated extra-cellular polymeric substances (EPS) and microbial products. Microorganisms and their products convene together to form matrices that are commonly treated as a black box in conventional control approaches. Biological-based antifouling strategies seem to be a promising constituent of an effective integrated control approach since they target the essence of biofouling problems. However, biological-based strategies are in their developmental phase and several questions should be addressed to set a roadmap for translating existing and new information into sustainable and effective control techniques. This paper investigates membrane biofouling in MBRs from the microbiological perspective to evaluate the potential of biological-based strategies in offering viable control alternatives. Limitations of available control methods highlight the importance of an integrated anti-fouling approach including biological strategies. Successful development of these strategies requires detailed characterization of microorganisms and EPS through the proper selection of analytical tools and assembly of results. Existing microbiological/EPS studies reveal a number of

  9. Do biological-based strategies hold promise to biofouling control in MBRs?

    Science.gov (United States)

    Malaeb, Lilian; Le-Clech, Pierre; Vrouwenvelder, Johannes S; Ayoub, George M; Saikaly, Pascal E

    2013-10-01

    Biofouling in membrane bioreactors (MBRs) remains a primary challenge for their wider application, despite the growing acceptance of MBRs worldwide. Research studies on membrane fouling are extensive in the literature, with more than 200 publications on MBR fouling in the last 3 years; yet, improvements in practice on biofouling control and management have been remarkably slow. Commonly applied cleaning methods are only partially effective and membrane replacement often becomes frequent. The reason for the slow advancement in successful control of biofouling is largely attributed to the complex interactions of involved biological compounds and the lack of representative-for-practice experimental approaches to evaluate potential effective control strategies. Biofouling is driven by microorganisms and their associated extra-cellular polymeric substances (EPS) and microbial products. Microorganisms and their products convene together to form matrices that are commonly treated as a black box in conventional control approaches. Biological-based antifouling strategies seem to be a promising constituent of an effective integrated control approach since they target the essence of biofouling problems. However, biological-based strategies are in their developmental phase and several questions should be addressed to set a roadmap for translating existing and new information into sustainable and effective control techniques. This paper investigates membrane biofouling in MBRs from the microbiological perspective to evaluate the potential of biological-based strategies in offering viable control alternatives. Limitations of available control methods highlight the importance of an integrated anti-fouling approach including biological strategies. Successful development of these strategies requires detailed characterization of microorganisms and EPS through the proper selection of analytical tools and assembly of results. Existing microbiological/EPS studies reveal a number of

  10. Promises

    Institute of Scientific and Technical Information of China (English)

    1998-01-01

    AT dusk, I switched on my radio. What I heard was a special call-in program entitled "New Air of the City," on a local music channel; the two silver-tongued hosts were discussing the topic of promises. A young woman with a soft voice managed to get through first. She said that she had been in love for many years. She and her fiance often went to the banks of the Yangtze River in their spare time, lifting stones to look for small crabs, as tiny as fingernails. They liked to raise the crabs in a glass bowl. But one day, there were few stones by the river; they searched for a long time, but found nothing. An old man who was catching fish told them that it was difficult to find those crabs on the bank. Then he took several crabs out of his

  11. Transmission electron microscopy investigation of Pt/Ba0.7Sr0.3TiO3/Pt capacitors with different annealing processes

    NARCIS (Netherlands)

    Qin, Y.L.; Jia, C.L.; Liedtke, R.; Waser, R.; Urban, K.

    2003-01-01

    The effects of postannealing in oxygen ambient and forming gas atmosphere (FGA) on the microstructure and chemistry of Pt/Ba0.7Sr0.3TiO3 (BST)/Pt capacitors prepared by chemical solution deposition have been investigated by means of transmission electron microscopy. The as-deposited film layers of t

  12. New strategies for the treatment of Parkinson's disease hold considerable promise for future management of neurodegenerative disorders

    DEFF Research Database (Denmark)

    Bjarkam, Carsten Reidies; Sørensen, Jens Christian; Sunde, Niels Å;

    2001-01-01

    Neurodegenerative diseases are often consideredincurable with no efficient therapies to modifyor halt the progress of disease, and ultimatelylead to reduced quality of life and to death.Our knowledge of the nervous system in healthand disease has, however, increasedconsiderably during the last...... fifty years andtoday, neuroscience reveals promising newstrategies to deal with disorders of thenervous system.Some of these results have been implementedwith success in the treatment of Parkinson'sdisease, a common neurodegenerative illnessaffecting approximately 1% of the populationaged seventy...... or more. Parkinson's disease ischaracterized by a massive loss of dopaminergicneurons in the substantia nigra, leading tosevere functional disturbance of the neuronalcircuitry in the basal ganglia. A thoroughdescription of basal ganglia circuitry inhealth and disease is presented. We describehow...

  13. Suppression of slow capacitance relaxation phenomenon in Pt/Ba0.3Sr0.7TiO3/Pt thin film ferroelectric structures by annealing in oxygen atmosphere

    KAUST Repository

    Altynnikov, A. G.

    2014-01-27

    The impact of oxygen annealing on the switching time of ferroelectric thin film capacitor structures Pt/Ba0.3Sr0.7TiO3/Pt was investigated. The response of their capacitance on pulsed control voltages before and after annealing was experimentally measured. It was demonstrated that the annealing results in suppression of the capacitance slow relaxation processes and increase of the threshold control voltages. These structures can therefore be attractive for fabrication of fast acting microwave devices. © 2014 Author(s).

  14. Fuzzy promises

    DEFF Research Database (Denmark)

    Anker, Thomas Boysen; Kappel, Klemens; Eadie, Douglas

    2012-01-01

    This article clarifies the commonplace assumption that brands make promises by developing definitions of brand promise delivery. Distinguishing between clear and fuzzy brand promises, we develop definitions of what it is for a brand to deliver on fuzzy functional, symbolic, and experiential...

  15. African rivers hold promise of major energy supply

    Energy Technology Data Exchange (ETDEWEB)

    Eskillson, E.

    1978-07-01

    Completion of a group of hydroelectric projects in southern Africa will provide a source of renewable energy to the area and could result in a subcontinental power grid. A project planned for the Orange River, South Africa's largest water system, will eventually include nine dams, 20 power stations, tunnels, and a system of irrigation canals. Projects for the Cunene River (which forms the Angolan-Namibian border), the Zambesi, Kafue, Zaire, and Great Ruaha Rivers are all described in terms of construction status and total planned generating capacity.

  16. Magnetic resonance spectroscopy may hold promise in studying metabolites, tissues

    Energy Technology Data Exchange (ETDEWEB)

    1989-02-24

    Almost 15 years ago, in a basement at Chicago's University of Illinois Medical Center, Michael Barany, MD, PhD, measured phosphorus metabolites in an intact frog muscle using magnetic resonance spectroscopy (MRS). Prior to that, chemists used spectroscopy solely to analyze the contents of test tubes. Only a British group preceded Barany in proving that it would work in tissue as well. Today, he does spectroscopy clinically, one day a week, at the Greenberg Radiology Institute in Highland Park, IL, north of Chicago. Barany says that he can distinguish malignant from benign tumors in the living brain. The tool he uses is a standard magnetic resonance imaging (MRI) machine. While MRI capabilities have forged ahead, human MRS has been awaiting improvements in magnet and computer technology. Barany is one of a number of researchers who, since the early 1980s, have been developing MRS technology and techniques so that it can be done in the human body.

  17. Big data in nephrology: promises and pitfalls.

    Science.gov (United States)

    Nadkarni, Girish N; Coca, Steven G; Wyatt, Christina M

    2016-08-01

    Data from the electronic health records hold great promise for nephrology research. However, due to significant limitations, reporting guidelines have been formulated for analyses conducted using electronic health records data.

  18. Small holding circles

    CERN Document Server

    Fruchard, Augustin

    2010-01-01

    A circle C holds a convex body K if C does not meet the interior of K and if there does not exist any euclidean displacement which moves C as far as desired from K, avoiding the interior of K. The purpose of this note is to explore how small can be a holding circle.

  19. Promises, promises for neuroscience and law.

    Science.gov (United States)

    Buckholtz, Joshua W; Faigman, David L

    2014-09-22

    Stunning technical advances in the ability to image the human brain have provoked excited speculation about the application of neuroscience to other fields. The 'promise' of neuroscience for law has been touted with particular enthusiasm. Here, we contend that this promise elides fundamental conceptual issues that limit the usefulness of neuroscience for law. Recommendations for overcoming these challenges are offered.

  20. Behavioural activation: history, evidence and promise.

    Science.gov (United States)

    Kanter, Jonathan W; Puspitasari, Ajeng J; Santos, Maria M; Nagy, Gabriela A

    2012-05-01

    Behavioural activation holds promise to reduce the global burden of depression as a treatment approach that is effective, easy to teach, scalable and acceptable to providers and patients across settings and cultures. This editorial reviews the history of behavioural activation, what it is, current evidence for its use and future directions.

  1. The holding environment and intersubjectivity.

    Science.gov (United States)

    Ginot, E

    2001-04-01

    The holding environment is explored in the context of the analytic dyad, where it is seen as rooted in the patient's need to be experientially known through the intersubjective interaction. In examining previous emphasis on holding as an optimally attuned empathic environment provided by the analyst, a broadened view of what constitutes a holding environment is presented, underscoring its interactional nature. A distinction is made between empathic holding based on the patient's expressed material, and holding that is generated through the analyst's intersubjective knowledge, gained via ongoing intersubjective engagements and enactments. It is argued that the unmediated connection to the patient's internal representations resulting from these intersubjective interactions, and the ensuing verbal exploration of them, can create a profound sense of being understood and thus held. A clinical process depicting the experience of holding in an intersubjective context is presented.

  2. Promises in Different Cultures

    Institute of Scientific and Technical Information of China (English)

    Holly Shi

    2001-01-01

    This paper reports a pilot study, which examines culture differences in a social function of language, i.e.,the function of promise making using Searle′s constitutive rules. It is to argue that different cultures may have the same type of speech-act such as promise, which, however, represents different cultural concepts. Evidence supporting the argument was drawn from a comparison of performance of Americans and Orientals concerning their respective concepts of promise making.

  3. Promise Zones for Applicants

    Data.gov (United States)

    Department of Housing and Urban Development — This tool assists applicants to HUD's Promise Zone initiative prepare data to submit with their application by allowing applicants to draw the exact location of the...

  4. Recombinant allergens: what does the future hold?

    Science.gov (United States)

    Valenta, Rudolf; Niespodziana, Katarzyna; Focke-Tejkl, Margit; Marth, Katharina; Huber, Hans; Neubauer, Angela; Niederberger, Verena

    2011-04-01

    This year we are celebrating not only the centenary of allergen-specific immunotherapy but also the 10-year anniversary of the first administration of recombinant allergen-based vaccines to allergic patients. By using recombinant DNA technology, defined and safe allergy vaccines can be produced that allow us to overcome many, if not all, of the problems associated with the use of natural allergen extracts, such as insufficient quality, allergenic activity, and poor immunogenicity. Here we provide an update of clinical studies with recombinant allergen-based vaccines, showing that some of these vaccines have undergone successful clinical evaluation up to phase III studies. Furthermore, we introduce a strategy for allergen-specific immunotherapy based on recombinant fusion proteins consisting of viral carrier proteins and allergen-derived peptides without allergenic activity, which holds the promise of being free of side effects and eventually being useful for prophylactic vaccination.

  5. Promising More Information

    Science.gov (United States)

    2003-01-01

    When NASA needed a real-time, online database system capable of tracking documentation changes in its propulsion test facilities, engineers at Stennis Space Center joined with ECT International, of Brookfield, Wisconsin, to create a solution. Through NASA's Dual-Use Program, ECT developed Exdata, a software program that works within the company's existing Promise software. Exdata not only satisfied NASA s requirements, but also expanded ECT s commercial product line. Promise, ECT s primary product, is an intelligent software program with specialized functions for designing and documenting electrical control systems. An addon to AutoCAD software, Promis e generates control system schematics, panel layouts, bills of material, wire lists, and terminal plans. The drawing functions include symbol libraries, macros, and automatic line breaking. Primary Promise customers include manufacturing companies, utilities, and other organizations with complex processes to control.

  6. The promise of dialogue

    DEFF Research Database (Denmark)

    Phillips, Louise Jane

    It has become commonplace to employ dialogue-based approaches in producing and communicating knowledge in diverse fields. Here, “dialogue” has become a buzzword that promises democratic, participatory processes of mutual learning and knowledge co-production. But what does “dialogue” actually entail...... in the fields in which it is practised and how can we analyse those practices in ways that take account of their complexities? The Promise of Dialogue presents a novel theoretical framework for analysing the dialogic turn in the production and communication of knowledge that builds bridges across three research...

  7. The Capability to Hold Property

    NARCIS (Netherlands)

    Claassen, Rutger|info:eu-repo/dai/nl/269266224

    2015-01-01

    This paper discusses the question of whether a capability theory of justice (such as that of Martha Nussbaum) should accept a basic “capability to hold property.” Answering this question is vital for bridging the gap between abstract capability theories of justice and their institutional implication

  8. 75 FR 81405 - Portfolio Holdings

    Science.gov (United States)

    2010-12-28

    ... portfolio parameters in response to conditions in the market. Related to the process of adjusting the..., Office of the General Counsel, (202) 414-3798, or Valerie Smith, Office of Policy Analysis and Research... to provide a liquid secondary market through securitization activities, the portfolio holdings...

  9. The Capability to Hold Property

    NARCIS (Netherlands)

    Claassen, Rutger|info:eu-repo/dai/nl/269266224

    2015-01-01

    This paper discusses the question of whether a capability theory of justice (such as that of Martha Nussbaum) should accept a basic “capability to hold property.” Answering this question is vital for bridging the gap between abstract capability theories of justice and their institutional

  10. Is Bitcoin Promising?

    Institute of Scientific and Technical Information of China (English)

    张程程

    2014-01-01

    On 26th Feb. 2014, the biggest Bitcoin trading platform al over the world was of line. It was bankrupt due to data theft. Global Bitcoin players got into a panic. Is Bitcoin promising? Below I wil analyze this question on several aspects, which are Bitcoins’ traits, demerits, and contrasts.

  11. Promising change, delivering continuity

    DEFF Research Database (Denmark)

    Lund, Jens Friis; Sungusia, Eliezeri; Mabele, Mathew Bukhi;

    2017-01-01

    have conceptualized REDD+ as an example of ‘‘green grabbing” and have voiced fears of a potential global rush for land and trees. In this paper we argue that, in practice and up until now, REDD+ resembles longstanding dynamics of the development and conservation industry, where the promise of change...

  12. Fish Hold Effluent and Fish Hold Cleaning Wastewater Discharge

    Science.gov (United States)

    2011-11-01

    summarized in Table 1). EPA estimated that mid-size fishing vessels, such as gill netters , and purse seiners found in Alaska, and shrimp boats in the Gulf...size fishing boats such as gill netters , fish holds are typically cleaned using a garden hose at a flow rate of approximately 10 to 12 gpm (USEPA...Small: salmon trollers and longliners 1,500 Daily when fishing 500 - 600 150 - 200 Mid-size: gill netters , purse seiners and shrimp boats

  13. Optimization of Holding Temperature and Holding Thickness for Controlled Rolling on Plate Mill

    Institute of Scientific and Technical Information of China (English)

    HU Xian-lei; ZHAO Zhong; WANG Jun; WANG Zhao-dong; LIU Xiang-hua; WANG Guo-dong

    2006-01-01

    Holding temperature and holding thickness are main parameters for two-phase controlled rolling on plate mill. The optimization of holding temperature and holding thickness for pass schedule calculation of two-phase controlled rolling on plate mill was presented and its feature is as follows: (1) Determination of holding thickness can be automatically obtained based on the influence of mill safety limits, tracking zone length and holding time on holding thickness; (2) Determination of holding temperature can be automatically obtained and the holding time can be reduced as much as possible; (3) Algorithm can modify the holding temperature and thickness depending on slab size and product size.

  14. SPECIALIZATION AND SUSTAINABLE DEVELOPMENT OF AGRICULTURAL HOLDINGS

    Directory of Open Access Journals (Sweden)

    Zofia Kołoszko-Chomentowska

    2016-03-01

    Full Text Available In the present article, an attempt was made to assess the sustainability of agricultural holdings with diff erent directions of production. Agricultural holdings in the Podlaskie voivodeship registered in the FADN system in 2011–2012 were investigated. Assessment accounted for agroecological indicators (share of permanent grasslands, share of cereals in crops, soil coverage with vegetation, stock density and economic indicators (profi tableness of land and labor. Analysis was conducted according to a classifi cation into agricultural holding types: fi eldcrops, dairy cattle, and granivores. Fieldcrop and granivore holdings achieved more favourable environmental sustainability indicators. Holdings specializing in dairy cattle breeding posed a threat to the natural environment, mainly due to their excessive stock density. Economic sustainability assessment showed that granivore holdings were assessed most favorably. In these holdings, holding income per full-time worker was 37% greater than in fi eldcrop holdings and 57% greater than in dairy cattle holdings.

  15. China Rare Earth Holdings Limited

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    China Rare Earth Holdings Limited is a large trans-area corporation and a public company listed in Hong Kong Stock Exchange (Name: China Rare Earth, Code: 0769), with headquarter in Hong Kong. Located on the bank of beautiful Taihu Lake, the subsidiary in Yinxing covers area of 200,000 m2. It has nearly 1,000 employees, 30% of whom are technical staffs. After self-administration and effort, the company passed ISO 9001: 2000 and ISO 14000 Certificaitons.

  16. Holding Costs and Equilibrium Arbitrage

    OpenAIRE

    Tuckman, Bruce; Vila, Jean-Luc

    1993-01-01

    This paper constructs a dynamic model of the equilibrium determination of relative prices when arbitragers face holding costs. The major findings are that 1) models based on riskless arbitrage arguments alone may not provide usefully tight bounds on observed prices, 2) arbitragers are often most effective in eliminating the mispricings of shorter-term assets, 3) arbitrage activity increases the mean reversion of changes in the mispricing process and reduces their conditional volatility, and 4...

  17. Do More Economists Hold Stocks?

    DEFF Research Database (Denmark)

    Christiansen, Charlotte; Joensen, Juanna Schröter; Rangvid, Jesper

    , even when controlling for several background characteristics. We make use of a large register-based panel data set containing detailed information on the educational attainments and various financial and socioeconomic variables. We model the stock market participation decision by the probit model......A unique data set enables us to test the hypothesis that more economists than otherwise identical investors hold stocks due to informational advantages. We confirm that economists have a significantly higher probability of participating in the stock market than investors with any other education...

  18. Determinants of agricultural holdings sustainability

    Directory of Open Access Journals (Sweden)

    Wioletta Wrzaszcz

    2012-04-01

    Full Text Available Agricultural policy in the European Union, at the Community level, as well as Member Countries, increasingly emphasize the issue of sustainable development of agriculture. This is a response to the multiplying threats to the environment. Referring to this problem, it was justified to estimate the level of agricultural holdings sustainability (on the basis of FADN data and recognize its determinants. There was applied multidimensional statistical analysis and logistic regression. The research indicated that identification of environmentally friendly agriculture with low profit production is ungrounded.

  19. China’s Secondary Aluminum Industry Holds Big Promise for Sustainable Growth

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    <正> In 2002,China’s primary aluminum productiontopped the world with a total output of 4,335,000 tons,ending China’s 100-odd years historyas a net importer of aluminum,a milestoneevent for China’s aluminum industry.Accord-ing to predictions,China’s production of alu-minum will reach 6.5 million tons by 2005,andwill exceed 9 million tons by 2010 based on aproduction capacity of 10 million tons.Overthe next 10 years,China’s production of secon-dary aluminum is expected to see an annualgrowth rate of over 9.5 percent.

  20. New Study on Dog Cancer May Hold Promise for Humans Too

    Institute of Scientific and Technical Information of China (English)

    李毅

    2008-01-01

    由俄勒冈州立大学兽医学院和俄勒冈卫生科技大学癌症研究所的科研人员合作进行的研究发现,为治疗犬科动物血管肉瘤而研制的药物可能令罹患类似疾病的人类受益,因为二者的居住环境相似,患病模式相似而且犬科动物的寿命够长,适合进行科研。

  1. Resolvins and aliamides: lipid autacoids in ophthalmology – what promise do they hold?

    Directory of Open Access Journals (Sweden)

    Hesselink JMK

    2016-09-01

    Full Text Available Jan M Keppel Hesselink,1 Flavia Chiosi,2 Ciro Costagliola2 1University of Witten/Herdecke, Witten, Germany; 2Eye Clinic, Department of Medicine and Health Sciences, University of Molise, Campobasso, Italy Abstract: Resolvins are a novel class of lipid-derived endogenous molecules (autacoids with potent immunomodulating properties, which regulate the resolution phase of an active immune response. These modulating factors are locally produced, influencing the function of cells and/or tissues, which are produced on demand and subsequently metabolized in the same cells and/or tissues. This review is focused on certain lipid autacoids with putative relevance for ophthalmology in general and for dry eye more specifically. We also briefly investigate the concept of aliamides and the role of palmitoylethanolamide in ophthalmology, and analyze in more detail the putative role and the preclinical and clinical development of resolvins as emerging treatments for dry eye and related disorders, with a focus on one of the lead resolvin derivatives – RX-10045. Keywords: resolvins, autacoids, aliamides, dry eye, palmitoylethanolamide, inflammation, ophthalmology, protection

  2. Allowance Holdings and Transfers Data Inventory

    Data.gov (United States)

    U.S. Environmental Protection Agency — The Allowance Holdings and Transfers Data Inventory contains measured data on holdings and transactions of allowances under the NOx Budget Trading Program (NBP), a...

  3. 76 FR 36625 - Mutual Holding Company

    Science.gov (United States)

    2011-06-22

    ... Office of Thrift Supervision Mutual Holding Company AGENCY: Office of Thrift Supervision (OTS), Treasury... collection. Title of Proposal: Mutual Holding Company. OMB Number: 1550-0072. Form Numbers: MHC-1 (OTS Form... whether the applicant meets the statutory and regulatory criteria to form a mutual holding company...

  4. 76 FR 20458 - Mutual Holding Company

    Science.gov (United States)

    2011-04-12

    ... Office of Thrift Supervision Mutual Holding Company AGENCY: Office of Thrift Supervision (OTS), Treasury... collection. Title of Proposal: Mutual Holding Company. OMB Number: 1550-0072. Form Numbers: MHC-1 (OTS Form... whether the applicant meets the statutory and regulatory criteria to form a mutual holding company...

  5. Functional Analysis and Intervention for Breath Holding.

    Science.gov (United States)

    Kern, Lee; And Others

    1995-01-01

    A functional analysis of breath-holding episodes in a 7-year-old girl with severe mental retardation and Cornelia-de-Lange syndrome indicated that breath holding served an operant function, primarily to gain access to attention. Use of extinction, scheduled attention, and a picture card communication system decreased breath holding. (Author/SW)

  6. 47 CFR 73.7005 - Holding period.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 4 2010-10-01 2010-10-01 false Holding period. 73.7005 Section 73.7005... Applications for Noncommercial Educational Stations on Non-Reserved Channels § 73.7005 Holding period. (a... holding period. From the grant of the construction permit and continuing until the facility has achieved...

  7. 9 CFR 2.101 - Holding period.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Holding period. 2.101 Section 2.101... WELFARE REGULATIONS Compliance With Standards and Holding Period § 2.101 Holding period. (a) Any live dog... and control, for a period of not less than 5 full days, not including the day of acquisition, after...

  8. A LITERATURE REVIEW OF COMPANIES CASH HOLDINGS

    Directory of Open Access Journals (Sweden)

    Iuliana Oana Mihai

    2015-05-01

    Full Text Available The purpose of this article is to investigate the scientific literature related to cash holdings of non-financial companies. We concentrated in our work on motives, determinants and theories of cash holding. The result of this study will enhance understanding of cash holding determinants and relevance of postulated theories in Romanian context. The main objective is to.

  9. ALICE Holds Up to Challenge

    CERN Multimedia

    2006-01-01

    ALICE's main austenitic stainless steel support structure (the Space Frame) has recently gone through many tests that proved quite challenging: insuring the structure is sound and lowering it horizontally into the ALICE cavern. This structure is constructed to hold the large volume detectors, such as the Time Projection Chamber, Transition Radiation Detector and Time of Flight inside the ALICE solenoid magnet. After the final assembly at CERN, two large mobile cranes were needed for the job of lifting and turning the 14 tonne frame onto its side. Once shifted, it was placed in Building SX2, one of the surface assembly areas designated for ALICE. The structure, which is 8 m in diameter and 7 m long, underwent many tests in its new position. Geometric control tests were performed by measuring each of the 18 cells and placing wooden or metal samples constructed to the same dimensions as the real thing inside the structure. The most important check was the movement of the real Time Projection Chamber from its s...

  10. Breath-holding and its breakpoint.

    Science.gov (United States)

    Parkes, M J

    2006-01-01

    This article reviews the basic properties of breath-holding in humans and the possible causes of the breath at breakpoint. The simplest objective measure of breath-holding is its duration, but even this is highly variable. Breath-holding is a voluntary act, but normal subjects appear unable to breath-hold to unconsciousness. A powerful involuntary mechanism normally overrides voluntary breath-holding and causes the breath that defines the breakpoint. The occurrence of the breakpoint breath does not appear to be caused solely by a mechanism involving lung or chest shrinkage, partial pressures of blood gases or the carotid arterial chemoreceptors. This is despite the well-known properties of breath-hold duration being prolonged by large lung inflations, hyperoxia and hypocapnia and being shortened by the converse manoeuvres and by increased metabolic rate. Breath-holding has, however, two much less well-known but important properties. First, the central respiratory rhythm appears to continue throughout breath-holding. Humans cannot therefore stop their central respiratory rhythm voluntarily. Instead, they merely suppress expression of their central respiratory rhythm and voluntarily 'hold' the chest at a chosen volume, possibly assisted by some tonic diaphragm activity. Second, breath-hold duration is prolonged by bilateral paralysis of the phrenic or vagus nerves. Possibly the contribution to the breakpoint from stimulation of diaphragm muscle chemoreceptors is greater than has previously been considered. At present there is no simple explanation for the breakpoint that encompasses all these properties.

  11. The Promises of Biology and the Biology of Promises

    DEFF Research Database (Denmark)

    Lee, Jieun

    2015-01-01

    commitments with differently imagined futures. I argue that promises are constitutive of the stem cell biology, rather than being derivative of it. Since the biological concept of stem cells is predicated on the future that they promise, the biological life of stem cells is inextricably intertwined...... patients’ bodies in anticipation of materializing the promises of stem cell biology, they are produced as a new form of biovaluable. The promises of biology move beyond the closed circuit of scientific knowledge production, and proliferate in the speculative marketplaces of promises. Part II looks at how...... of technologized biology and biological time can appear promising with the backdrop of the imagined intransigence of social, political, and economic order in the Korean society....

  12. The Promises of Biology and the Biology of Promises

    DEFF Research Database (Denmark)

    Lee, Jieun

    2015-01-01

    commitments with differently imagined futures. I argue that promises are constitutive of the stem cell biology, rather than being derivative of it. Since the biological concept of stem cells is predicated on the future that they promise, the biological life of stem cells is inextricably intertwined...... patients’ bodies in anticipation of materializing the promises of stem cell biology, they are produced as a new form of biovaluable. The promises of biology move beyond the closed circuit of scientific knowledge production, and proliferate in the speculative marketplaces of promises. Part II looks at how...... of technologized biology and biological time can appear promising with the backdrop of the imagined intransigence of social, political, and economic order in the Korean society....

  13. Holdings as a Measure of Journal Value.

    Science.gov (United States)

    Wallace, Danny P.; Boyce, Bert R.

    1989-01-01

    Describes a study that compared holdings figures from the OCLC database to productivity measures from the "Journal Citation Reports" section of "Science Citation Index" and publisher circulation figures to determine whether there is a systematic relationship between easily gathered holdings and circulation figures and less…

  14. Course holding by cyclists and moped riders.

    NARCIS (Netherlands)

    Godthelp, J. & Wouters, P.I.J.

    1980-01-01

    Course holding by cyclists and moped riders includes both steering alongside a course and stabilising the vehicle. Inability to hold course may lead to conflicts with other road users. To design safe bicycle and moped facilities and to consider the safety of those existing, knowledge about performan

  15. Error-Compensated Integrate and Hold

    Science.gov (United States)

    Matlin, M.

    1984-01-01

    Differencing circuit cancels error caused by switching transistors capacitance. In integrate and hold circuit using JFET switch, gate-to-source capacitance causes error in output voltage. Differential connection cancels out error. Applications in systems where very low voltages sampled or many integrate-and -hold cycles before circuit is reset.

  16. Inflation, operating cycle, and cash holdings

    Institute of Scientific and Technical Information of China (English)

    Yanchao; Wang; Yu; Ji; Xu; Chen; Chunlei; Song

    2014-01-01

    A corporate cash-holding strategy is a trade-off between the costs and benefits of holding cash.At the macrolevel,firms are inclined to adjust and optimize their cash-holding strategies in response to changes in purchasing power due to inflation.At the microlevel,the operating cycle,which indicates the speed and turnover of corporate cash flow,also influences the corporate cash-holding strategy.Firms flexibly adjust their cash-holding strategies in response to changes in the internal and external environment,which is referred to as the cash adjustment strategy.We examine these predicted relationships using a sample of listed firms in China’s stock market over the 1998–2009 period.Consistent with our predictions,the empirical results indicate a significant negative association between cash holdings and the CPI,but the relationship is reversed when the CPI reaches a certain level.There is also a U-shaped relationship between operating cycle and cash holdings,and this relationship is similarly influenced by changes in the inflation level.In examining the macroeconomic environment and microlevel firm-specific characteristics simultaneously,our findings supplement the literature on firms’cash-holding strategies and provide theoretical and practical implications.

  17. Unconditional Schools, Youth of Promise.

    Science.gov (United States)

    Lloyd, David

    2001-01-01

    This article contrasts schools of exclusion with unconditional schools, which are designed to wrap around services to meet the needs of even high-risk students. The author describes essential components of developing a teamwork approach to increase the holding power of schools with challenging students. (Author)

  18. JavaScript promises essentials

    CERN Document Server

    Sarieddine, Rami

    2014-01-01

    If you are a JavaScript developer working with asynchronous operations and want to know more about promises, then this book is ideal for you. Having a detailed explanation of JavaScript promises will be perfect as your next step towards adopting this new standard and using the API in your web and JavaScript applications.

  19. Utility, limitations, and promise of proteomics in animal science.

    Science.gov (United States)

    Lippolis, John D; Reinhardt, Timothy A

    2010-12-15

    Proteomics experiments have the ability to simultaneously identify and quantify thousands of proteins in one experiment. The use of this technology in veterinary/animal science is still in its infancy, yet it holds significant promise as a method for advancing veterinary/animal science research. Examples of current experimental designs and capabilities of proteomic technology and basic principles of mass spectrometry are discussed. In addition, challenges and limitations of proteomics are presented, stressing those that are unique to veterinary/animal sciences.

  20. 78 FR 66097 - Acies Corporation, Immtech Pharmaceuticals, Inc., MRU Holdings, Inc., MSTI Holdings, Inc., Nestor...

    Science.gov (United States)

    2013-11-04

    ... From the Federal Register Online via the Government Publishing Office SECURITIES AND EXCHANGE COMMISSION Acies Corporation, Immtech Pharmaceuticals, Inc., MRU Holdings, Inc., MSTI Holdings, Inc., Nestor... concerning the securities of MRU Holdings, Inc. because it has not filed any periodic reports since the...

  1. 78 FR 2481 - Watco Holdings, Inc., Watco Railroad Company Holdings, Inc., & Watco Acquisition Sub, Inc...

    Science.gov (United States)

    2013-01-11

    ... Acquisition Sub, Inc.--Acquisition of Control Exemption--Ann Arbor Railroad, Inc. Watco Holdings, Inc. (Watco Holdings), Watco Railroad Company Holdings, Inc. (Watco Railroad), and Watco Acquisition Sub, Inc. (Merger Sub), all noncarriers, have filed a verified notice of exemption under 49 CFR 1180.2(d)(2) for...

  2. 77 FR 48550 - Sears Holdings Management Corporation, A Division of Sears Holdings Corporation, Hoffman Estates...

    Science.gov (United States)

    2012-08-14

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF LABOR Employment and Training Administration Sears Holdings Management Corporation, A Division of Sears Holdings... workers at the Hoffman Estates, Illinois facility are similarly situated as the Sears Holdings workers...

  3. Collective behaviors of book holding durations

    Science.gov (United States)

    Li, Ren-De; Guo, Qiang; Han, Jing-Ti; Liu, Jian-Guo

    2016-10-01

    Duration can directly reflect the collective reading behaviors of library user book holding. In this paper, by introducing the burstiness and memory coefficients, we empirically investigate the collective book holding behavior of three university libraries. The statistical results show that there are similar properties among the students with different backgrounds, presenting the burstiness = - 0.2 and memory = 0.5 for three datasets, which indicates that memory and random effects coexist in student book holding durations. In addition, we analyze the behavior patterns without duplicate durations by merging a series of books borrowed and returned at the same time. The results show the average burstiness B increases to -0.16 and memory M drops to 0.16 for three datasets, which indicates that both duplicate behavior and student's preference affect the memory effect. Furthermore, we present a model which assumes student's next book holding duration follows the previous one with probability p, and with probability 1 - p, the student would hold the book independently. The experimental results show that the presented model can reproduce the burstiness and memory effect of student book holding durations when p = 0.5 for empirical datasets and p = 0.2 for de-duplicate datasets, which indicate that the student's preferential holding behavior occurs with the probability p. This work helps in deeply understanding the regularity of duration-based human behaviors.

  4. Bilateral trade, openness and asset holdings

    OpenAIRE

    Peter, Alexandra

    2010-01-01

    This paper analyzes the relationship between bilateral trade flows, trade openness, and asset holdings in a three-country stochastic general equilibrium model. The threecountry model set-up enables me to disentangle and separate the effects bilateral trade flows and trade openness have on bilateral portfolio patterns. I find that both factors independently influence bilateral asset holdings. Higher bilateral trade as well as higher trade openness lead to a higher bilateral foreign asset posit...

  5. Mastering JavaScript promises

    CERN Document Server

    Hussain, Muzzamil

    2015-01-01

    This book is for all the software and web engineers wanting to apply the promises paradigm to their next project and get the best outcome from it. This book also acts as a reference for the engineers who are already using promises in their projects and want to improve their current knowledge to reach the next level. To get the most benefit from this book, you should know basic programming concepts, have a familiarity with JavaScript, and a good understanding of HTML.

  6. EOQ Models with Varying Holding Cost

    Directory of Open Access Journals (Sweden)

    Naser Ghasemi

    2013-01-01

    Full Text Available Models of inventory management contain different parameters. An issue is observable in the classical models which can be related to the determination of the quantity of the economic order and the quantity of the economic production. In these models, the parameters like setup and holding costs and also the rate of demands are fixed. This matter causes the quantity of the economic ordering in classic model to have some differences in comparison with the real-world conditions. It should be stated that holding cost of spoiled and useless products is not always fixed and so the costs increase by passing the time. This paper is an attempt to develop classical EOQ models by considering holding cost as an increasing function of the ordering cycle length. So the classical EOQ models are developed, and the related optimum quantity to the ordering cycle length, economic ordering quantity, and the optimum total cost are determined.

  7. Decompression sickness following breath-hold diving.

    Science.gov (United States)

    Schipke, J D; Gams, E; Kallweit, Oliver

    2006-01-01

    Despite convincing evidence of a relationship between breath-hold diving and decompression sickness (DCS), the causal connection is only slowly being accepted. Only the more recent textbooks have acknowledged the risks of repetitive breath-hold diving. We compare four groups of breath-hold divers: (1) Japanese and Korean amas and other divers from the Pacific area, (2) instructors at naval training facilities, (3) spear fishers, and (4) free-dive athletes. While the number of amas is likely decreasing, and Scandinavian Navy training facilities recorded only a few accidents, the number of spear fishers suffering accidents is on the rise, in particular during championships or using scooters. Finally, national and international associations (e.g., International Association of Free Drives [IAFD] or Association Internationale pour Le Developpment De L'Apnee [AIDA]) promote free-diving championships including deep diving categories such as constant weight, variable weight, and no limit. A number of free-diving athletes, training for or participating in competitions, are increasingly accident prone as the world record is presently set at a depth of 171 m. This review presents data found after searching Medline and ISI Web of Science and using appropriate Internet search engines (e.g., Google). We report some 90 cases in which DCS occurred after repetitive breath-hold dives. Even today, the risk of suffering from DCS after repetitive breath-hold diving is often not acknowledged. We strongly suggest that breath-hold divers and their advisors and physicians be made aware of the possibility of DCS and of the appropriate therapeutic measures to be taken when DCS is suspected. Because the risk of suffering from DCS increases depending on depth, bottom time, rate of ascent, and duration of surface intervals, some approaches to assess the risks are presented. Regrettably, none of these approaches is widely accepted. We propose therefore the development of easily manageable

  8. The Ambivalence of Promising Technology

    NARCIS (Netherlands)

    Shelley-Egan, Clare

    2010-01-01

    Issues of responsibility in the world of nanotechnology are becoming explicit with the emergence of a discourse on ‘responsible development’ of nanoscience and nanotechnologies. Much of this discourse centres on the ambivalences of nanotechnology and of promising technology in general. Actors must f

  9. The effect of friction in the hold down post spherical bearings on hold down post loads

    Science.gov (United States)

    Richardson, James A.

    1990-01-01

    The effect of friction at the connection of the Solid Rocket Booster (SRB) aft skirt and the mobile launch platform (MLP) hold down posts was analyzed. A simplified model of the shuttle response during the Space Shuttle Main Engine (SSME) buildup was constructed. The model included the effect of stick-slip friction for the rotation of the skirt about the spherical bearing. Current finite element models assume the joint is completely frictionless in rotation and therefore no moment is transferred between the skirt and the hold down posts. The model was partially verified against test data and preliminary parameter studies were performed. The parameter studies indicated that the coefficient of friction strongly influenced the moment on the hold down posts. The coefficient of friction had little effect on hold down post vertical loads, however. Further calibration of the model is necessary before the effect of friction on the hold down post horizontal loads can be analyzed.

  10. Towards a classification of weak hand holds

    NARCIS (Netherlands)

    Kimmelman, V.; Sáfár, A.; Crasborn, O.

    2016-01-01

    The two symmetrical manual articulators (the hands) in signed languages are a striking modalityspecific phonetic property. The weak hand can maintain the end position of an articulation while the other articulator continues to produce additional signs. This weak hand spreading (hold) has been

  11. Holding Kids Accountable: Shaming with Compassion.

    Science.gov (United States)

    Campbell, H. Allen; Revering, Andrew C.

    1997-01-01

    Describes the philosophy and procedures of Police Accountability Conferencing, a restorative justice approach in which police and school authorities, victims, offenders, and families are brought together in a process designed to hold youth accountable for their actions. Details the program's potential for reclaiming youth who have engaged in…

  12. Should we Hold the Obese Responsible?

    DEFF Research Database (Denmark)

    Nielsen, Morten Ebbe Juul; Andersen, Martin Marchman

    2014-01-01

    holding the obese responsible will have positive consequences. Taking these two conceptions of responsibility into account, the authors turn their analysis toward examining the relevant moral considerations to be taken into account when public policies regarding obesity rely on such a conception...

  13. 12 CFR 1732.7 - Record hold.

    Science.gov (United States)

    2010-01-01

    ... retention program of an Enterprise shall: (1) Address how employees and, as appropriate, how agents or... AND SOUNDNESS RECORD RETENTION Record Retention Program § 1732.7 Record hold. (a) Definition. For... permissible destruction of records; and, (3) Provide that any employee and, as appropriate, any agent or...

  14. How Much Popcorn Will Our Classroom Hold?

    Science.gov (United States)

    Rommel-Esham, Katie

    2007-01-01

    "How much popcorn will our classroom hold?" This intriguing question sparked a terrific integrated science and math exploration that the author conducted with fifth-and sixth-grade students. In the process of finding the classroom's volume, students developed science-process skills (e.g., developing a plan, measurement, collecting and interpreting…

  15. Empowerment Amongst Teachers Holding Leadership Positions

    Science.gov (United States)

    Avidov-Ungar, Orit; Friedman, Izhak; Olshtain, Elite

    2014-01-01

    This study used semi-structured in-depth interviews to explore empowerment patterns among teachers who hold leadership positions in school. Our qualitative analysis presents a hierarchical ladder with three types of empowerment amongst these teachers, ranging from limited empowerment through rewarding empowerment to change-enhancing empowerment.…

  16. Uncertainty Quantification for Cargo Hold Fires

    CERN Document Server

    DeGennaro, Anthony M; Martinelli, Luigi; Rowley, Clarence W

    2015-01-01

    The purpose of this study is twofold -- first, to introduce the application of high-order discontinuous Galerkin methods to buoyancy-driven cargo hold fire simulations, second, to explore statistical variation in the fluid dynamics of a cargo hold fire given parameterized uncertainty in the fire source location and temperature. Cargo hold fires represent a class of problems that require highly-accurate computational methods to simulate faithfully. Hence, we use an in-house discontinuous Galerkin code to treat these flows. Cargo hold fires also exhibit a large amount of uncertainty with respect to the boundary conditions. Thus, the second aim of this paper is to quantify the resulting uncertainty in the flow, using tools from the uncertainty quantification community to ensure that our efforts require a minimal number of simulations. We expect that the results of this study will provide statistical insight into the effects of fire location and temperature on cargo fires, and also assist in the optimization of f...

  17. The Promise of Quantum Simulation

    CERN Document Server

    Muller, Richard P

    2015-01-01

    Quantum simulation promises to be one of the primary application of quantum computers, should one be constructed. This article briefly summarizes the history quantum simulation in light of the recent result of Wang and coworkers demonstrating calculation of the ground and excited states for a HeH+ molecule, and concludes with a discussion of why this and other recent progress in the field suggests that quantum simulation of quantum chemistry has a bright future.

  18. The promise of cyborg intelligence.

    Science.gov (United States)

    Brown, Michael F; Brown, Alexander A

    2017-03-01

    Yu et al. (2016) demonstrated that algorithms designed to find efficient routes in standard mazes can be integrated with the natural processes controlling rat navigation and spatial choices, and they pointed out the promise of such "cyborg intelligence" for biorobotic applications. Here, we briefly describe Yu et al.'s work, explore its relevance to the study of comparative cognition, and indicate how work involving cyborg intelligence would benefit from interdisciplinary collaboration between behavioral scientists and engineers.

  19. Nanomaterials promise better bone repair

    OpenAIRE

    Qifei Wang; Jianhua Yan; Junlin Yang; Bingyun Li

    2016-01-01

    Nanomaterials mimicking the nano-features of bones and offering unique smart functions are promising for better bone fracture repair. This review provides an overview of the current state-of-the-art research in developing and using nanomaterials for better bone fracture repair. This review begins with a brief introduction of bone fracture repair processes, then discusses the importance of vascularization, the role of growth factors in bone fracture repair, and the failure of bone fracture rep...

  20. 12 CFR 583.20 - Savings and loan holding company.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Savings and loan holding company. 583.20... REGULATIONS AFFECTING SAVINGS AND LOAN HOLDING COMPANIES § 583.20 Savings and loan holding company. The term savings and loan holding company means any company that directly or indirectly controls a...

  1. 12 CFR 583.4 - Bank holding company.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Bank holding company. 583.4 Section 583.4 Banks... AFFECTING SAVINGS AND LOAN HOLDING COMPANIES § 583.4 Bank holding company. The term bank holding company means any company which has control over any bank or over any company that is or becomes a bank...

  2. Chitin fulfilling a biomaterials promise

    CERN Document Server

    Khor, Eugene

    2001-01-01

    The second edition of Chitin underscores the important factors for standardizing chitin processing and characterization. It captures the essential interplay between chitin's assets and limitations as a biomaterial, placing the past promises of chitin in perspective, addressing its present realities and offering insight into what is required to realize chitin's destiny (including its derivative, chitosan) as a biomaterial of the twenty-first century. This book is an ideal guide for both industrialists and researchers with a vested interest in commercializing chitin.An upd

  3. Living on Hold in Palliative Cancer Care

    Directory of Open Access Journals (Sweden)

    Anna Sandgren, RN, M.Sc.N., Ph.D. Student

    2010-02-01

    Full Text Available The aim of this study was to develop a classic grounded theory of palliative cancer patients and their relatives in the context of home care. We analyzed interviews and data related to the behaviour of both patients and relatives. “Living on hold” emerged as the pattern of behaviour through which the patients and relatives deal with their main concern, being put on hold. Living on Hold involves three modes: Fighting, Adjusting and Surrendering. Mode being may change during a trajectory depending on many different factors. There are also different triggers that can start a reconciling process leading to a change of mode. This means that patients and relatives can either be in the same mode or in different modes simultaneously. More or less synchronous modes may lead to problems and conflicts within the family, or with the health professionals.

  4. Latino Immigrants, Acculturation, and Health: Promising New Directions in Research.

    Science.gov (United States)

    Abraído-Lanza, Ana F; Echeverría, Sandra E; Flórez, Karen R

    2016-01-01

    This article provides an analysis of novel topics emerging in recent years in research on Latino immigrants, acculturation, and health. In the past ten years, the number of studies assessing new ways to conceptualize and understand how acculturation-related processes may influence health has grown. These new frameworks draw from integrative approaches testing new ground to acknowledge the fundamental role of context and policy. We classify the emerging body of evidence according to themes that we identify as promising directions--intrapersonal, interpersonal, social environmental, community, political, and global contexts, cross-cutting themes in life course and developmental approaches, and segmented assimilation--and discuss the challenges and opportunities each theme presents. This body of work, which considers acculturation in context, points to the emergence of a new wave of research that holds great promise in driving forward the study of Latino immigrants, acculturation, and health. We provide suggestions to further advance the ideologic and methodologic rigor of this new wave.

  5. Electrochemical cell with electrode hold-down

    Energy Technology Data Exchange (ETDEWEB)

    Boudrot, R.J.; Shambaugh, J.S.; Zeltzer, H.

    1981-06-30

    A primary electrochemical cell including a hold-down unit for securing and preventing movement of a physically large battery stack of the cell is disclosed. The battery stack is disposed within a rectangular metal housing of the cell, together with an electrolytic solution, and comprises a large number of rectangular anodes and cathode structures arranged in the battery stack in alternation. The hold-down unit is disposed in the cell in abutment with the top of the battery stack and an inner surface of a cover assembly secured to the housing. The hold-down unit includes a pair of opposed end sections in abutment with the interior surfaces of one pair of walls of the housing and lying orthogonally to the planes of the components of the battery stack, and a pair of opposed connecting sections in abutment with the interior surfaces of the other pair of walls of the housing and interconnecting the pair of end sections. The connecting sections are spaced from the battery stack and define, together with the end sections, top and side openings. These openings, together with large openings in the end sections, minimize the displacement of electrolytic solution in the region of the cell above the battery stack. The connecting sections further include insulated, resilient, angularly-oriented tabs capable of deflection by contact with the top cover assembly for compensating for variations in tolerances associated with the manufacture and assembly of the components of the cell.

  6. RDoC: Translating promise into progress.

    Science.gov (United States)

    Patrick, Christopher J; Hajcak, Greg

    2016-03-01

    As highlighted by articles in the current special issue, the RDoC initiative holds promise for advancing understanding of mental health problems. However, the initiative is at its early stages and it remains unclear what level of progress can be achieved and how quickly. In this closing article, we identify major challenges facing RDoC and propose concrete approaches to addressing these challenges, including (a) clearer specification of clinical problems for study, with use of symptom dimensions from integrative dimensional models of psychopathology as provisional, modifiable referents; (b) encouragement of research on a distinct set of traits corresponding to process constructs from the RDoC matrix-those represented across animal, child temperament, and adult personality literatures-to serve as interfaces between matrix constructs and clinical problems; (c) an emphasis in the near term on use of proximal units of analysis in RDoC studies-in particular, on physiological, behavioral, and self-report measures of matrix constructs (examined as states or traits, or both); (d) inclusion of a clear ontogenetic-developmental component in RDoC research projects; (e) routine analysis of the psychometric properties of nonreport (e.g., physiological, task-behavioral) variables, including systematic evaluation of their reliability and convergent-discriminant validity; (f) modification of existing grant review criteria to prioritize replication and synergy in RDoC investigative work; and (g) creation of a cumulative data network system (RDoC-DataWeb) to encourage and facilitate coordination of research efforts across RDoC research groups.

  7. 12 CFR 584.2-2 - Permissible bank holding company activities of savings and loan holding companies.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Permissible bank holding company activities of savings and loan holding companies. 584.2-2 Section 584.2-2 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY SAVINGS AND LOAN HOLDING COMPANIES § 584.2-2 Permissible bank holding...

  8. The promise of psychiatric pharmacogenomics.

    Science.gov (United States)

    Hamilton, Steven P

    2015-01-01

    Clinicians already face "personalized" medicine every day while experiencing the great variation in toxicities and drug efficacy among individual patients. Pharmacogenetics studies are the platform for discovering the DNA determinants of variability in drug response and tolerability. Research now focuses on the genome after its beginning with analyses of single genes. Therapeutic outcomes from several psychotropic drugs have been weakly linked to specific genetic variants without independent replication. Drug side effects show stronger associations to genetic variants, including human leukocyte antigen loci with carbamazepine-induced dermatologic outcome and MC4R with atypical antipsychotic weight gain. Clinical implementation has proven challenging, with barriers including a lack of replicable prospective evidence for clinical utility required for altering medical care. More recent studies show promising approaches for reducing these barriers to routine incorporation of pharmacogenetics data into clinical care.

  9. Mangiferin: a promising anticancer bioactive.

    Science.gov (United States)

    Khurana, Rajneet K; Kaur, Ranjot; Lohan, Shikha; Singh, Kamalinder K; Singh, Bhupinder

    2016-05-01

    Of late, several biologically active antioxidants from natural products have been investigated by the researchers in order to combat the root cause of carcinogenesis, in other words, oxidative stress. Mangiferin, a therapeutically active C-glucosylated xanthone, is extracted from pulp, peel, seed, bark and leaf of Mangifera indica. These polyphenols of mangiferin exhibit antioxidant properties and tend to decrease the oxygen-free radicals, thereby reducing the DNA damage. Indeed, its capability to modulate several key inflammatory pathways undoubtedly helps in stalling the progression of carcinogenesis. The current review article emphasizes an updated account on the patents published on the chemopreventive action of mangiferin, apoptosis induction made on various cancer cells, along with proposed antioxidative activities and patent mapping of other important therapeutic properties. Considering it as promising polyphenol, this paper would also summarize the diverse molecular targets of mangiferin.

  10. Purines: from premise to promise.

    Science.gov (United States)

    Williams, M

    2000-07-01

    Geoff Burnstock's remarkable insight and tenacity has established the area of purinergic research as a bona fide target for drug discovery. While efforts in P1 receptor-based medicinal chemistry and biology efforts over the past 25 years have not reached the level of success that the pharmaceutical industry investment may have anticipated, the P2 area, with knowledge of the selective localization of members of the P2X and P2Y family members and data from transgenic knockouts, has identified several potential therapeutic areas of major promise including cystic fibrosis, chronic bronchitis, male contraception and neurodegeneration. In addition, interest in the potential of purinergic therapeutics has extended outside the major pharmaceutical companies to the 'biotech industry' resulting in an environment where the inherent risks of 'first in field' in a therapeutic area may be more appropriately nurtured.

  11. Nanomaterials promise better bone repair

    Directory of Open Access Journals (Sweden)

    Qifei Wang

    2016-10-01

    Full Text Available Nanomaterials mimicking the nano-features of bones and offering unique smart functions are promising for better bone fracture repair. This review provides an overview of the current state-of-the-art research in developing and using nanomaterials for better bone fracture repair. This review begins with a brief introduction of bone fracture repair processes, then discusses the importance of vascularization, the role of growth factors in bone fracture repair, and the failure of bone fracture repair. Next, the review discusses the applications of nanomaterials for bone fracture repair, with a focus on the recent breakthroughs such as nanomaterials leading to precise immobilization of growth factors at the molecular level, promoting vascularization without the use of growth factors, and re-loading therapeutic agents after implantation. The review concludes with perspectives on challenges and future directions for developing nanomaterials for improved bone fracture repair.

  12. Cultural Neuroscience: Progress and Promise.

    Science.gov (United States)

    Chiao, Joan Y; Cheon, Bobby K; Pornpattanangkul, Narun; Mrazek, Alissa J; Blizinsky, Katherine D

    2013-01-01

    The nature and origin of human diversity has been a source of intellectual curiosity since the beginning of human history. Contemporary advances in cultural and biological sciences provide unique opportunities for the emerging field of cultural neuroscience. Research in cultural neuroscience examines how cultural and genetic diversity shape the human mind, brain and behavior across multiple time scales: situation, ontogeny and phylogeny. Recent progress in cultural neuroscience provides novel theoretical frameworks for understanding the complex interaction of environmental, cultural and genetic factors in the production of adaptive human behavior. Here, we provide a brief history of cultural neuroscience, theoretical and methodological advances, as well as empirical evidence of the promise of and progress in the field. Implications of this research for population health disparities and public policy are discussed.

  13. What Happened to the Promise? A Critical (Re)Orientation of Two Sociocultural Learning Traditions

    Science.gov (United States)

    Niewolny, Kim L.; Wilson, Arthur L.

    2009-01-01

    Cleary it is no longer possible to think about learning without context. Although context cannot be ignored anymore, educators often struggle to explain how people learn in "and" with various contexts. Situated cognition and cultural--historical activity theory (CHAT) hold promise for understanding how adult learners are cultural and historical…

  14. 32 CFR 806b.9 - Confidentiality promises.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 6 2010-07-01 2010-07-01 false Confidentiality promises. 806b.9 Section 806b.9... PROGRAM Obtaining Law Enforcement Records and Confidentiality Promises § 806b.9 Confidentiality promises. Promises of confidentiality must be prominently annotated in the record to protect from disclosure any...

  15. Are Economists More Likely to Hold Stocks?

    DEFF Research Database (Denmark)

    Christiansen, Charlotte; Joensen, Eyðfrið Juanna Schrøter; Rangvid, Jesper

    education, even when controlling for several background characteristics. We make use of a large register-based panel data set containing detailed information on the educational attainments and various financial and socioeconomic variables.We model the stock market participation decision by the probit model......A unique data set enables us to test the hypothesis that due to informational advantages economists are more likely to hold stocks than otherwise identical investors. Weconfirm that economists have a significantly higher probability of participating in the stockmarket than investors with any other...

  16. Should we Hold the Obese Responsible?

    DEFF Research Database (Denmark)

    Nielsen, Morten Ebbe Juul; Andersen, Martin Marchman

    2014-01-01

    conceptualizations of responsibility: backward-looking and forward-looking conceptualizations. When ascertaining responsibility in a backward-looking sense, one has to determine how that state of affairs came into being or where the agent stood in relation to it. In contrast, a forward-looking conceptualization...... holding the obese responsible will have positive consequences. Taking these two conceptions of responsibility into account, the authors turn their analysis toward examining the relevant moral considerations to be taken into account when public policies regarding obesity rely on such a conception...

  17. New strategies for the treatment of Parkinson's disease hold considerable promise for future management of neurodegenerative disorders

    DEFF Research Database (Denmark)

    Bjarkam, Carsten Reidies; Sørensen, Jens Christian; Sunde, Niels Å

    2001-01-01

    Neurodegenerative diseases are often consideredincurable with no efficient therapies to modifyor halt the progress of disease, and ultimatelylead to reduced quality of life and to death.Our knowledge of the nervous system in healthand disease has, however, increasedconsiderably during the last fi...

  18. The Ambivalence of Promising Technology.

    Science.gov (United States)

    Shelley-Egan, Clare

    2010-08-01

    Issues of responsibility in the world of nanotechnology are becoming explicit with the emergence of a discourse on 'responsible development' of nanoscience and nanotechnologies. Much of this discourse centres on the ambivalences of nanotechnology and of promising technology in general. Actors must find means of dealing with these ambivalences. Actors' actions and responses to ambivalence are shaped by their position and context, along with strategic games they are involved in, together with other actors. A number of interviews were conducted with industrial actors with the aim of uncovering their ethical stances towards responsible development of nanotechnology. The data shows that standard repertoires of justification of nanotechnological development were used. Thus, the industrial actors fell back on their position and associated responsibilities. Such responses reinforce a division of moral labour in which industrial actors and scientists can focus on the progress of science and technology, while other actors, such as NGOs, are expected to take care of broader considerations, such as ethical and social issues.

  19. Automated Inventory Control System for Nigeria Power Holding

    African Journals Online (AJOL)

    PROF. O. E. OSUAGWU

    2013-09-01

    Sep 1, 2013 ... Power Holding Company of Nigeria (PHCN) currently holds in excess of millions in spare parts inventory between ... Heightened operational risks, lower availability and ... expectations, demand uncertainty, and the flexibility of ...

  20. [Status and prospects for development of medical equipment at the state-of-the-art "Axion Holding" "Izhevskiy Motor Plant"].

    Science.gov (United States)

    Makarov, A N; Mubarakshin, R G

    2002-01-01

    The joint stock company "Izhevsky Motor Plant "AXION-HOLDING" is a large manufacturer in different industrial branches, including medical equipment. The paper presents data on the status-of-the-art and prospects of development in producing medical equipment in several areas, including information on specific articles that are manufactured and promising.

  1. 26 CFR 1.563-2 - Personal holding company tax.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 7 2010-04-01 2010-04-01 true Personal holding company tax. 1.563-2 Section 1... (CONTINUED) INCOME TAXES (CONTINUED) Deduction for Dividends Paid § 1.563-2 Personal holding company tax. In the case of a personal holding company subject to the provisions of section 541, dividends paid...

  2. 42 CFR 412.344 - Hold-harmless payment methodology.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 2 2010-10-01 2010-10-01 false Hold-harmless payment methodology. 412.344 Section...-Related Costs § 412.344 Hold-harmless payment methodology. (a) General. A hospital paid under the hold-harmless payment methodology receives a payment per discharge based on the higher of: (1) 85 percent of...

  3. Creditor rights, country governance, and corporate cash holdings

    NARCIS (Netherlands)

    Seifert, Bruce; Gonenc, Halit

    2016-01-01

    This study examines the impact of creditor rights and country governance on cash holdings using a sample of firms from 47 countries. We hypothesize that cash holdings are smaller when both creditor rights and country governance are high. In these circumstances firms will not need to hold as much cas

  4. A mathematical model of aerosol holding chambers

    DEFF Research Database (Denmark)

    Zak, M; Madsen, J; Berg, E

    1999-01-01

    A mathematical model of aerosol delivery from holding chambers (spacers) was developed incorporating tidal volume (VT), chamber volume (Vch), apparatus dead space (VD), effect of valve insufficiency and other leaks, loss of aerosol by immediate impact on the chamber wall, and fallout of aerosol...... in the chamber with time. Four different spacers were connected via filters to a mechanical lung model, and aerosol delivery during "breathing" was determined from drug recovery from the filters. The formula correctly predicted the delivery of budesonide aerosol from the AeroChamber (Trudell Medical, London......, Ontario, Canada), NebuChamber (Astra, Södirtälje, Sweden) and Nebuhaler (Astra) adapted for babies. The dose of fluticasone proportionate delivered by the Babyhaler (Glaxco Wellcome, Oxbridge, Middlesex, UK) was 80% of that predicted, probably because of incomplete priming of this spacer. Of the above...

  5. Antigen Loss Variants: Catching Hold of Escaping Foes

    Science.gov (United States)

    Vyas, Maulik; Müller, Rolf; Pogge von Strandmann, Elke

    2017-01-01

    Since mid-1990s, the field of cancer immunotherapy has seen steady growth and selected immunotherapies are now a routine and preferred therapeutic option of certain malignancies. Both active and passive cancer immunotherapies exploit the fact that tumor cells express specific antigens on the cell surface, thereby mounting an immune response specifically against malignant cells. It is well established that cancer cells typically lose surface antigens following natural or therapy-induced selective pressure and these antigen-loss variants are often the population that causes therapy-resistant relapse. CD19 and CD20 antigen loss in acute lymphocytic leukemia and chronic lymphocytic leukemia, respectively, and lineage switching in leukemia associated with mixed lineage leukemia (MLL) gene rearrangements are well-documented evidences in this regard. Although increasing number of novel immunotherapies are being developed, majority of these do not address the control of antigen loss variants. Here, we review the occurrence of antigen loss variants in leukemia and discuss the therapeutic strategies to tackle the same. We also present an approach of dual-targeting immunoligand effectively retargeting NK cells against antigen loss variants in MLL-associated leukemia. Novel immunotherapies simultaneously targeting more than one tumor antigen certainly hold promise to completely eradicate tumor and prevent therapy-resistant relapses. PMID:28286501

  6. A Promising Development: "Promise" Scholarships Targeting Individual Communities Reduce Barriers to College Access--and Completion

    Science.gov (United States)

    Pierce, Dennis

    2015-01-01

    This article discusses Promise Scholarships in community colleges and sources of funding. The following community colleges and their scholarships are mentioned in this article: (1) Oregon Promise, Oregon; (2) Ventura College Promise, California; (3) Kalamazoo Promise, Michigan; (4) Pittsburgh Promise, Pennsylvania; (5) SEED Scholarship, Delaware;…

  7. Mental models students hold of zoos

    Science.gov (United States)

    Patrick, Patricia Gail

    The purpose of this study was to depict the mental models high school students, ages 14-18, hold of zoos. This study also examined how students define conservation and the role of zoos in conservation. This study examined the differences in mental models of 84 students (1) 21 students who had visited a zoo with their teacher in the same semester in which the study was conducted, (2) 21 students who had visited a zoo during another school year with their teacher, (3) 21 students who had visited the zoo without a teacher, and (4) 21 students who had never visited a zoo. It also examined the mental models of students of different ethnicities and examined differences in mental models of young men and women. This study was conducted and the data analyzed using a qualitative methodology research design. All 84 students completed a demographic questionnaire, a concept map, and a ranking concepts exercise. Twenty-four students were interviewed. The findings indicated that: (1) students who had visited a zoo have a richer mental model of zoos than students who have never visited a zoo, (2) students who had visited a zoo with their teacher provided a deeper richer understanding of the roles of zoos in conservation and education, (3) students who have never visited a zoo do have mental models of zoos, (4) students do not mention conservation with respect to zoos unless specifically asked about the role of zoos in conservation, and (5) students did not mention the zoo's connection to species survival nor did they view zoos as a source of information for conservation-related topics. The data indicated that the mental models student hold of zoos consist of seven themes: (1) organisms, (2) people, (3) amenities, (4) descriptive terms, (5) habitats, (6) education, and (7) conservation. The seven themes were defined and used to create the Zoo Acuity Model. The central constructs of the Zoo Acuity Model are the Observation Framework, the Interaction Framework, and the Information

  8. Realizing the promise of social psychology in improving public health.

    Science.gov (United States)

    Klein, William M P; Shepperd, James A; Suls, Jerry; Rothman, Alexander J; Croyle, Robert T

    2015-02-01

    The theories, phenomena, empirical findings, and methodological approaches that characterize contemporary social psychology hold much promise for addressing enduring problems in public health. Indeed, social psychologists played a major role in the development of the discipline of health psychology during the 1970s and 1980s. The health domain allows for the testing, refinement, and application of many interesting and important research questions in social psychology, and offers the discipline a chance to enhance its reach and visibility. Nevertheless, in a review of recent articles in two major social-psychological journals (Personality and Social Psychology Bulletin and Journal of Personality and Social Psychology), we found that only 3.2% of 467 studies explored health-related topics. In this article, we identify opportunities for research at the interface of social psychology and health, delineate barriers, and offer strategies that can address these barriers as the discipline continues to evolve.

  9. Piracetam in severe breath holding spells.

    Science.gov (United States)

    Azam, Matloob; Bhatti, Nasera; Shahab, Naheed

    2008-01-01

    Breath holding spells (BHS) are apparently frightening events occurring in otherwise healthy children. Generally, no medical treatment is recommended and parental reassurance is believed to be enough, however, severe BHS can be very stressful for the parents and a pharmacological agent may be desired in some of these children. In this prospective study aim was to determine the usefulness of piracetam as prophylactic treatment for severe BHS. Children were recruited from Neurology Clinic in Children's Hospital, Islamabad between January 2002 to December 2004. Diagnosis of BHS was based on characteristic history and normal physical examination. Piracetam was prescribed to those children who were diagnosed as severe BHS in a dose ranging from 50-100 mg/kg/day. Iron supplements were added if hemoglobin was less than 10 gm%. Patients were seen at 2-4 weeks interval and follow-up was continued until 3 months after the cessation of drug therapy. Fifty-two children were enrolled in the study, 34 boys and 18 girls. Ages ranged from 4 weeks to 5 years with mean age of 17 months. In 81% of children, spells disappeared completely and in 9% frequency was reduced to less than one per month and of much lesser intensity. Prophylaxis was given for 3-6 months (mean 5) duration. Piracetam is an effective prophylactic treatment for severe BHS.

  10. Intangible Capital and Corporate Cash Holdings: Theory and Evidence

    OpenAIRE

    Dalida Kadyrzhanova; Antonio Falato; Jae Sim

    2012-01-01

    The rise in intangible capital is a fundamental driver of the secular trend in US corporate cash holdings over the last decades. We construct a new measure of intangible capital and show that intangible capital is the most important firm-level determinant of corporate cash holdings. Our measure accounts for almost as much of the secular increase in cash since the 1980s as all other standard determinants together. We then develop a new model of corporate cash holdings that introduces intangibl...

  11. Multiple Job Holding, Local Labor Markets, and the Business Cycle

    OpenAIRE

    Hirsch, Barry T.; Husain, Muhammad M.; Winters, John V

    2016-01-01

    About 5 percent of U.S. workers hold multiple jobs, which can exacerbate or mitigate employment changes over the business cycle. Theory is ambiguous and prior literature is not fully conclusive. We examine the relationship between multiple job holding and local unemployment rates using a large Current Population Survey data set of workers in urban labor markets during 1998-2013. High unemployment labor markets have moderately lower rates of multiple job holding. Yet no relationship between mu...

  12. Sports-related lung injury during breath-hold diving

    Directory of Open Access Journals (Sweden)

    Tanja Mijacika

    2016-12-01

    Full Text Available The number of people practising recreational breath-hold diving is constantly growing, thereby increasing the need for knowledge of the acute and chronic effects such a sport could have on the health of participants. Breath-hold diving is potentially dangerous, mainly because of associated extreme environmental factors such as increased hydrostatic pressure, hypoxia, hypercapnia, hypothermia and strenuous exercise. In this article we focus on the effects of breath-hold diving on pulmonary function. Respiratory symptoms have been reported in almost 25% of breath-hold divers after repetitive diving sessions. Acutely, repetitive breath-hold diving may result in increased transpulmonary capillary pressure, leading to noncardiogenic oedema and/or alveolar haemorrhage. Furthermore, during a breath-hold dive, the chest and lungs are compressed by the increasing pressure of water. Rapid changes in lung air volume during descent or ascent can result in a lung injury known as pulmonary barotrauma. Factors that may influence individual susceptibility to breath-hold diving-induced lung injury range from underlying pulmonary or cardiac dysfunction to genetic predisposition. According to the available data, breath-holding does not result in chronic lung injury. However, studies of large populations of breath-hold divers are necessary to firmly exclude long-term lung damage.

  13. Sports-related lung injury during breath-hold diving.

    Science.gov (United States)

    Mijacika, Tanja; Dujic, Zeljko

    2016-12-01

    The number of people practising recreational breath-hold diving is constantly growing, thereby increasing the need for knowledge of the acute and chronic effects such a sport could have on the health of participants. Breath-hold diving is potentially dangerous, mainly because of associated extreme environmental factors such as increased hydrostatic pressure, hypoxia, hypercapnia, hypothermia and strenuous exercise.In this article we focus on the effects of breath-hold diving on pulmonary function. Respiratory symptoms have been reported in almost 25% of breath-hold divers after repetitive diving sessions. Acutely, repetitive breath-hold diving may result in increased transpulmonary capillary pressure, leading to noncardiogenic oedema and/or alveolar haemorrhage. Furthermore, during a breath-hold dive, the chest and lungs are compressed by the increasing pressure of water. Rapid changes in lung air volume during descent or ascent can result in a lung injury known as pulmonary barotrauma. Factors that may influence individual susceptibility to breath-hold diving-induced lung injury range from underlying pulmonary or cardiac dysfunction to genetic predisposition.According to the available data, breath-holding does not result in chronic lung injury. However, studies of large populations of breath-hold divers are necessary to firmly exclude long-term lung damage.

  14. Latino Immigrants, Acculturation, and Health: Promising New Directions in Research

    Science.gov (United States)

    Abraído-Lanza, Ana F.; Echeverría, Sandra E.; Flórez, Karen R.

    2017-01-01

    This article provides an analysis of novel topics emerging in recent years in research on Latino immigrants, acculturation, and health. In the past ten years, the number of studies assessing new ways to conceptualize and understand how acculturation-related processes may influence health has grown. These new frameworks draw from integrative approaches testing new ground to acknowledge the fundamental role of context and policy. We classify the emerging body of evidence according to themes that we identify as promising directions—intrapersonal, interpersonal, social environmental, community, political, and global contexts, cross-cutting themes in life course and developmental approaches, and segmented assimilation—and discuss the challenges and opportunities each theme presents. This body of work, which considers acculturation in context, points to the emergence of a new wave of research that holds great promise in driving forward the study of Latino immigrants, acculturation, and health. We provide suggestions to further advance the ideologic and methodologic rigor of this new wave. PMID:26735431

  15. The Promising Syllabus Enacted: One Teacher's Experience

    Science.gov (United States)

    Hirsch, Christine Courtade

    2010-01-01

    The purpose of this report is to describe a rationale and strategies for use of the Promising Syllabus (in Bain, 2004, What the best college teachers do). This syllabus reflects the learner-centered paradigm where students take charge of their own learning. The syllabus creates a series of promises between teacher and student, focusing on a…

  16. Realizing the promises of marine biotechnology

    NARCIS (Netherlands)

    Luiten, EEM; Akkerman, [No Value; Koulman, A; Kamermans, P; Reith, H; Barbosa, MJ; Sipkema, D; Wijffels, RH

    2003-01-01

    High-quality research in the field of marine biotechnology is one of the key-factors for successful innovation in exploiting the vast diversity of marine life. However, fascinating scientific research with promising results and claims on promising potential applications (e.g. for pharmaceuticals, nu

  17. 12 CFR 575.14 - Subsidiary holding companies.

    Science.gov (United States)

    2010-01-01

    ... the approval of its shareholders, except as otherwise provided in this section 5 or to the extent that... proposed by the board of directors of the MHC subsidiary holding company, approved by the shareholders by a... to subsidiary holding companies. (3) Optional charter provision limiting minority stock ownership....

  18. Er det etisk acceptabelt at holde elefanter i zoologiske haver?

    DEFF Research Database (Denmark)

    Sandøe, Peter

    2016-01-01

    Bag diskussionen om flytning af 17 vilde elefanter fra Afrika til amerikanske zoolgiske haver ligger en dybere uenighed om berettigelsen af at holde elefanter i fangenskab,......Bag diskussionen om flytning af 17 vilde elefanter fra Afrika til amerikanske zoolgiske haver ligger en dybere uenighed om berettigelsen af at holde elefanter i fangenskab,...

  19. Evaluation of Manometric Measures during Tongue-Hold Swallows

    Science.gov (United States)

    Doeltgen, Sebastian H.; Witte, Ulrike; Gumbley, Freya; Huckabee, Maggie-Lee

    2009-01-01

    Purpose: Based on visual inspection, prior research documented increased movement of the posterior pharyngeal wall in healthy volunteers during tongue-hold swallows. This manometric study investigated the immediate effects of the tongue-hold maneuver on pharyngeal peak pressure generation, duration of pressure generation, and pressure slope…

  20. Acute effects of cannabis on breath-holding duration.

    Science.gov (United States)

    Farris, Samantha G; Metrik, Jane

    2016-08-01

    Distress intolerance (an individual's perceived or actual inability to tolerate distressing psychological or physiological states) is associated with cannabis use. It is unknown whether a biobehavioral index of distress intolerance, breath-holding duration, is acutely influenced (increased or decreased) by cannabis. Such information may further inform understanding of the expression of psychological or physiological distress postcannabis use. This within-subjects study examined whether smoked marijuana with 2.7%-3.0% delta-9-tetrahydrocannabinol (THC), relative to placebo, acutely changed duration of breath holding. Participants (n = 88; 65.9% male) were nontreatment-seeking frequent cannabis users who smoked placebo or active THC cigarette on two separate study days and completed a breath-holding task postsmoking. Controlling for baseline breath-holding duration and participant sex, THC produced significantly shorter breath-holding durations relative to placebo. There was a significant interaction of drug administration × frequency of cannabis use, such that THC decreased breath-holding time among less frequent but not among more frequent users. Findings indicate that cannabis may exacerbate distress intolerance (via shorter breath-holding durations). As compared to less frequent cannabis users, frequent users display tolerance to cannabis' acute effects including increased ability to tolerate respiratory distress when holding breath. Objective measures of distress intolerance are sensitive to contextual factors such as acute drug intoxication, and may inform the link between cannabis use and the expression of psychological distress. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

  1. Forord, midtersider og efterord i Hold Ud Bro

    DEFF Research Database (Denmark)

    2016-01-01

    at skrive så nu sidder jeg bare her og surmuler så hold ud bro hold ud hold ud bro hold ud Grønthandleren, 19 år Vi sidder i et kælderlokale i skolen på Ringe Statsfængsel. Vi er syv mennesker, alle i gang med en skriveøvelse. I fem minutter skriver vi løs. Ingen siger noget, tastaturer klaprer...... Grønthandleren læser sin tekst højt, griner vi. Det er sjovt, fordi nogen af os ikke fatter, hvad en kartoffel (en hvid dansker) er. Så taler vi om uretfærdighed. Til sidst taler vi om slutningen, ”hold ud bro”. I teksten er det noget, forfatteren siger til sig selv: ”Så nu er jeg træt af at skrive så nu sidder...... jeg bare her og surmuler så hold ud bro hold ud.” Teksterne i ‘Hold ud bro’ er skrevet af tre unge indsatte i et skriveværksted, der fandt sted i Ringe Statsfængsel. Det foregik over tre dage i starten af marts 2016. Vi var tre unge indsatte, en lærer og tre skrivementorer. Vi arbejde primært med...

  2. 17 CFR 450.4 - Custodial holdings of government securities.

    Science.gov (United States)

    2010-04-01

    ... government securities. 450.4 Section 450.4 Commodity and Securities Exchanges DEPARTMENT OF THE TREASURY REGULATIONS UNDER TITLE II OF THE GOVERNMENT SECURITIES ACT OF 1986 CUSTODIAL HOLDINGS OF GOVERNMENT SECURITIES BY DEPOSITORY INSTITUTIONS § 450.4 Custodial holdings of government securities....

  3. Korean Investment in EU through Holding Companies: A Case Study

    Directory of Open Access Journals (Sweden)

    Seong-Bong Lee

    1998-09-01

    Full Text Available When transnational enterprises set subsidiary companies in certain area, their major aim is to invest indirectly through the holding companies which hold invested share. Especially, because of the geographical neighborhood and economic integration, investing by holding companies is common in Europe. In Europe, taking full advantage of holding company is out of the following two reasons. Firstly, the efficiency and flexibility of the manage strategy of a group could be elevated by making full use of the holding company. Secondly, the transnational enterprises have the possibility of flexible management at the tax strategy level. Recently, the Korean companies are making the best use of holding companies when they are Marching into the EU. In the year 1996, group K purchased 8 enterprises of a certain industry section of B, a German company, setting holding companies in Germany. The analysis result of the case shows that the manage efficiency could be risen and the taxation could be reduced by way of making use of holding companies. As to the Korean investment efficiency of overseas indirect investment in EU, this thesis brought forward a blueprint about integrating the local companies.

  4. Course holding by cyclists and moped riders. (Revised version).

    NARCIS (Netherlands)

    Godhelp, J. & Wouters, P.I.J.

    1980-01-01

    Course holding by cyclists and moped riders includes both steering alongside a course and stabilising the vehicle. Inability to hold course may lead to conflicts with other road users. To design safe bicycle and moped facilities and to consider the safety of those existing, knowledge about performan

  5. Residual magnetism holds solenoid armature in desired position

    Science.gov (United States)

    Crawford, R. P.

    1967-01-01

    Holding solenoid uses residual magnetism to hold its armature in a desired position after excitation current is removed from the coil. Although no electrical power or mechanical devices are used, the solenoid has a low tolerance to armature displacement from the equilibrium position.

  6. Er det etisk acceptabelt at holde elefanter i zoologiske haver?

    DEFF Research Database (Denmark)

    Sandøe, Peter

    2016-01-01

    Bag diskussionen om flytning af 17 vilde elefanter fra Afrika til amerikanske zoolgiske haver ligger en dybere uenighed om berettigelsen af at holde elefanter i fangenskab,......Bag diskussionen om flytning af 17 vilde elefanter fra Afrika til amerikanske zoolgiske haver ligger en dybere uenighed om berettigelsen af at holde elefanter i fangenskab,...

  7. Clinical holding with children who display behaviours that challenge.

    Science.gov (United States)

    Page, Andrea; McDonnell, Andrew; Gayson, Charlotte; Moss, Fiona; Mohammed, Needa; Smith, Claire; Vanes, Nicola

    Nurses hold children to administer treatment, prevent treatment interference and undertake clinical assessments, which can sometimes be invasive, as part of their regular duties. Clinical holding ensures this treatment or assessment is carried out safely, however, it has been reported that there is little training available in this area. This article explores the prevalent clinical holding techniques used by nursing staff when caring for children with behaviours that challenge. As an initial insight into what the researchers hope will become a more in-depth 2-year study, this investigation looks to explore current practice when holding children and the factors influencing this. It is hoped that this will inform the development of a training package offered to nurses when caring for these children. Thirteen semi-structured interviews took place with a small group of nurses, which were given thematic analysis. The overarching themes influencing holding practice were the nursing role itself along with intrinsic and external factors.

  8. The Parent Control in the Mechanical Engineering Management-Holding

    Science.gov (United States)

    Šnircová, Jana; Hodulíková, Petra; Joehnk, Peter

    2012-12-01

    The group of entities under the control of parent, so called holding, is arisen as the result and the most often used form of the business concentration nowadays. The paper is focused to find special tasks of parent company for to preserve effective unified economic control in the management-holding. The unified economic control the holding exists in the conditions of the main conflict of interest - holding is not a legal but economic unit and the connected companies into it have a legal autonomy with the economic dependence. The unified economic control limits the financial independence of every individual company of the holding. The attention in the paper is concentrated to the management concept of the parent control, i.e. the parent company supervises the control of intragroup flows and all of subsidiaries production activities.

  9. The Promise and Reality of Formative Assessment Practice in a Continuous Assessment Scheme: The Case of Trinidad and Tobago

    Science.gov (United States)

    De Lisle, Jerome

    2015-01-01

    Continuous Assessment (CA) systems are externally directed, curriculum-based assessment schemes used for both summative and formative purposes within classrooms. CA has been implemented as national policy in several postcolonial developing countries and is believed to hold great promise for improving education outcomes. This theory-driven…

  10. Fecal Transplant Shows Early Promise Against Autism

    Science.gov (United States)

    ... 163263.html Fecal Transplant Shows Early Promise Against Autism Small study found giving healthy gut bacteria to ... study suggests a novel treatment for kids with autism: Give these young patients a fresh supply of ...

  11. Diabetes Drug Shows Promise Against Parkinson's

    Science.gov (United States)

    ... fullstory_167612.html Diabetes Drug Shows Promise Against Parkinson's Byetta improved symptoms of motor disease in small, ... may do double duty as a treatment for Parkinson's disease, a new study suggests. "This is a ...

  12. New Eczema Drug Promising in Early Trial

    Science.gov (United States)

    ... page: https://medlineplus.gov/news/fullstory_163883.html New Eczema Drug Promising in Early Trial Nemolizumab significantly ... the appearance of moderate to severe eczema, a new, preliminary trial finds. Nemolizumab is a man-made, ...

  13. Panspermia: A Promising Field of Research

    Science.gov (United States)

    Rampelotto, P. H.

    2010-04-01

    In recent years, most of the major barriers against the acceptance of Panspermia have been demolished and this hypothesis emerges as a promising field of research. In this work, recent discoveries and the principal advances in Panspermia are discussed.

  14. Bus coordination holding control for transit hubs under APTS

    Institute of Scientific and Technical Information of China (English)

    TENG Jing; ZHAO Ming

    2009-01-01

    To increase the passenger transferring efficiency, the bus coordination holding control for transit hubs,hich is as an important dynamic dispatching method for improving the service level of transit hubs, was studied in the framework of bus coordination dispatching mode. Firstly, the bus coordination holding control flow was studied based on Advanced Public Transportation Systems (APTS) environment. Then a control model was presented to optimize the bus vehicle holding time, and a genetic algorithm was designed as the solving method. In the end, an example was given to illustrate the effectiveness of the control strategy and the algorithm.

  15. Evaluation of pulmonary function using single-breath-hold dual-energy computed tomography with xenon

    Science.gov (United States)

    Kyoyama, Hiroyuki; Hirata, Yusuke; Kikuchi, Satoshi; Sakai, Kosuke; Saito, Yuriko; Mikami, Shintaro; Moriyama, Gaku; Yanagita, Hisami; Watanabe, Wataru; Otani, Katharina; Honda, Norinari; Uematsu, Kazutsugu

    2017-01-01

    reflected pulmonary function. Xenon images obtained with xenon-enhanced CT using a single-breath-hold technique can qualitatively depict pulmonary ventilation. A larger study comprising only COPD patients should be conducted, as xenon-enhanced CT is expected to be a promising technique for the management of COPD. PMID:28099359

  16. Creating an enabling environment for adolescent sexual and reproductive health: a framework and promising approaches.

    Science.gov (United States)

    Svanemyr, Joar; Amin, Avni; Robles, Omar J; Greene, Margaret E

    2015-01-01

    This article provides a conceptual framework and points out the key elements for creating enabling environments for adolescent sexual and reproductive health (ASRH). An ecological framework is applied to organize the key elements of enabling environments for ASRH. At the individual level, strategies that are being implemented and seem promising are those that empower girls, build their individual assets, and create safe spaces. At the relationship level, strategies that are being implemented and seem promising include efforts to build parental support and communication as well as peer support networks. At the community level, strategies to engage men and boys and the wider community to transform gender and other social norms are being tested and may hold promise. Finally, at the broadest societal level, efforts to promote laws and policies that protect and promote human rights and address societal awareness about ASRH issues, including through mass media approaches, need to be considered.

  17. Hearing Loss Rates Holding Steady for U.S. Teens

    Science.gov (United States)

    ... page: https://medlineplus.gov/news/fullstory_167456.html Hearing Loss Rates Holding Steady for U.S. Teens: Study Vaccine ... via earphones than ever before, but rates of hearing loss have not increased. Still, "the overall take-home ...

  18. Ways for Romanian Holding Refreshment – a Point of View

    Directory of Open Access Journals (Sweden)

    Andrea Feher

    2010-10-01

    Full Text Available The current situation of the most Romanian holdings does not allow the performance of a high-quality and competitive agricultural production on the internal market and on the external market as well and the provision of a decent standard of living for farmers. The overtaking of this situation supposes the conversion of the country-like family holdings into modern trading family holdings, able to induce technological progress and to valorise the natural, labour and material resources available in our country. The activity content for the formation of such holdings is represented by the enhancement of their economic capacity and of their competitional power, in concordance with the requirements of future agriculture and of Romania’s integration in the EU structures. The accomplishment of such an objective implies actions and measures of agricultural policy, correlated to each other and sustainable, which should combine the private economic interest with the national one.

  19. Hold That Pose: Yoga May Ease Tough Depression

    Science.gov (United States)

    ... html Hold That Pose: Yoga May Ease Tough Depression Study finds weekly sessions, plus deep breathing, helped ... the doctor ordered when it comes to beating depression, new research suggests. Researchers found that weekly sessions ...

  20. Researchers Put Embryo Development 'On Hold' in Mice

    Science.gov (United States)

    ... medlineplus.gov/news/fullstory_162187.html Researchers Put Embryo Development 'On Hold' in Mice Putting stem cells ... were able to halt development of early mouse embryos for up to a month in the lab ...

  1. Southeast Region Headboat Survey-Compliance tracking holds list

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The holds list is used to track vessel compliance by recording any missing/late trip reports. This list is shared with enforcement officers in the event that legal...

  2. ENERGY STAR Certified Commercial Hot Food Holding Cabinet

    Data.gov (United States)

    U.S. Environmental Protection Agency — Certified models meet all ENERGY STAR requirements as listed in the Version 2.0 ENERGY STAR Program Requirements for Commercial Hot Food Holding Cabinets that are...

  3. Holding children in mind or holding therapy: developing an ethical position.

    Science.gov (United States)

    Simmonds, John

    2007-04-01

    Attachment theory and therapy have established themselves as major constructs in foster care and adoption practice. The depth of the explanatory power of attachment theory and research have done much to both identify the source of developmental difficulties in adopted and fostered children, and of the significant changes that can be made when these children are placed with 'autonomously' classified carers. However, the power of the concept has also led to a proliferation of ideas, particularly therapeutic models that can, in some cases, stray a long way from the core of what is effective, safe and ethical clinical practice. Holding therapy is one of these models. The British Association for Adoption and Fostering developed a position statement on this practice, setting it within a broader framework of assessment and intervention. But like the model, the development of the position statement became controversial in its development. The article charts some of the critical issues and identifies the very significant dilemmas for parents and carers caught up in the maelstrom of challenging behaviours and disturbing feelings. The conclusion turns to one of the key components of an attachment-based idea: The critical importance of finding the space to think and to feel what the child is communicating without resorting to dangerous retaliation.

  4. Little bottles and the promise of probiotics.

    Science.gov (United States)

    Burges Watson, Duika; Moreira, Tiago; Murtagh, Madeleine

    2009-03-01

    In this article we explore; regimes of hope' in contemporary bioscience as articulated in spaces of health consumption. We use the case study of probiotic little bottles, highlighting their promissory branding as consumer products, to consider how hope and truth play out across different spaces of health care - the supermarket, media and laboratory. Drawing on work within both sociological and geographic literatures to think about hope, truth and probiotics, this article explores their ambiguous promise through an analysis of their biomedical and popular representation. The seemingly incommensurate promise of probiotics between popular and medical spheres provides the point of departure for an examination of the geographies of hope, truth and selfhood.

  5. Tamarind seed polysaccharide: A promising natural excipient for pharmaceuticals

    Directory of Open Access Journals (Sweden)

    Joshny Joseph

    2012-01-01

    Full Text Available The natural polymers always have exceptional properties which make them distinct from the synthetic polymers and tamarind seed polysaccharide (TSP is one such example which shows more valuable properties making it a useful excipient for a wide range of applications. TSP is a natural polysaccharide obtained from the seeds of Tamarindus indica, recently gaining a wide potential in the field of pharmaceutical and cosmetic industries. Its isolation and characterisation involve simple techniques resulting in cost-effective yield in its production. TSP shows uniqueness in its high drug holding capacity, high swelling index and high thermal stability, especially necessary for various novel drug delivery systems. It also plays the role of stabiliser, thickener, binder, release retardant, modifier, suspending agent, viscosity enhancer, emulsifying agent, as a carrier for novel drug delivery systems in oral, buccal, colon, ocular systems, nanofabrication, wound dressing and is also becoming an important part of food, cosmetics, confectionery and bakery. Various studies and experiments have been carried out to prove its multi-functional potentiality, from which it can be concluded that TSP can be a promising natural polysaccharide having enormous applications. This review focuses on the diversity of applications of TSP.

  6. Gene Therapy Shows Promise for Aggressive Lymphoma

    Science.gov (United States)

    ... page: https://medlineplus.gov/news/fullstory_163824.html Gene Therapy Shows Promise for Aggressive Lymphoma Over one-third ... TUESDAY, Feb. 28, 2017 (HealthDay News) -- An experimental gene therapy for aggressive non-Hodgkin lymphoma beat back more ...

  7. Ideological Repositioning: Race, Social Justice, and Promise

    Science.gov (United States)

    Hodge, Samuel R.

    2014-01-01

    In this paper, I engage in discourse centrally located in the ideology of race in the United States of America juxtaposed to social justice with promise for tomorrow in higher education and beyond. I assert that social justice in kinesiology requires that once hired, retaining, securing tenured status, and promoting faculty of color means having…

  8. Collaboration: Perks, Problems, and Promising Practices.

    Science.gov (United States)

    Campbell-Whatley, Gloria; And Others

    1994-01-01

    General educator-special educator collaboration is discussed. Advantages include professional exchange of ideas and sharing of resources; barriers include a feeling by staff of lack of ownership and lack of power in decision making, and the perception that goals are incompatible; promising practices include clarifying goals and developing…

  9. Capture technologies: Improvements and promising developments

    NARCIS (Netherlands)

    Blomen, E.; Hendriks, C.; Neele, F.

    2009-01-01

    In this status report we want to provide a comprehensive overview of the current status and promising technologies of CO2 capture by means of a literature review, in-house knowledge and interviews. We describe the technology, bottlenecks towards implementation and potential use. The results will be

  10. Analysis of Hold Down Force for IVTM in PGSFR

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Nak Hyun; Koo, Gyeong-Hoi [KAERI, Daejeon (Korea, Republic of)

    2015-05-15

    The PGSFR (Prototype Generation IV Sodium Cooled Fast Reactor) is a new design for a compact sodium-cooled fast nuclear reactor. The main components of the IVTM (In-Vessel Transfer Machine) for PGSFR are composed of the upper driving part, the main tube and the pantograph arm including the gripper. The bottom of the pantograph arm has a tapered feature machined into it at the interface where it contacts the surrounding core assemblies when the hold down is engaged. A tapered feature on the core hold down assembly engages features in the top of the core assemblies and may help to reduce the deflections at the bottom of the main structural support tube while under refueling loads. Hold down force is one of the most important parameter for design IVTM. Elastic FE analysis was performed to calculate hold down force and displacement. The hold down force and displacement are 3626.8 N and -2.27 mm, respectively. The calculated values will be used to design IVTM for PGSFR. The maximum reaction force of fuel assembly is 641.05 N. The calculated values will be used to design receptacle and lower grid plate for PGSFR.

  11. Promising Products for Printing and Publishing Market

    Directory of Open Access Journals (Sweden)

    Renata Činčikaitė

    2011-04-01

    Full Text Available The article surveys printing and publishing market and its strong and weak aspects. The concept of a new product is described as well as its lifetime and the necessity of its introduction to the market. The enterprise X operating on the market is analyzed, its strong and weak characteristics are presented. The segmentation of the company consumers is performed. On the basis of the performed analysis the potential promising company products are defined.Article in Lithuanian

  12. PBL og de sammensatte hold på kandidatuddannelser

    DEFF Research Database (Denmark)

    Engen, Mie; Fallov, Mia Arp; Jensen, Rune Hagel Skaarup

    Denne rapport omhandler pædagogiske udfordringer og muligheder i Aalborgs Problembaserede Læringstilgang (PBL), når den omsættes til pædagogisk og didaktisk handling på kandidatuddannelser med sammensatte hold. Sammensatte hold betyder i denne sammenhæng kandidatuddannelser, hvor de optagne...... studerende har meget forskellige uddannelsesmæssige baggrunde. Rapporten formidler en didaktisk ramme for, hvordan PBL kan tilgås, når studerende på et kandidathold er meget forskellige, med henblik på at udnytte kompetencerne på de sammensatte hold bedst muligt og derved øge læringspotentialet....

  13. C-14/I-29 Preservation and Hold Time Survey

    Energy Technology Data Exchange (ETDEWEB)

    Kitchen, S. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

    2015-04-08

    Preservation and hold time of radionuclides must account for both nuclear half-lives and nonnuclear loss mechanisms, but variations in the latter are often neglected. Metals-based defaults are inappropriate for long-lived non-metals C-14 and I-129, which are vulnerable to chemical and biological volatilization. Non-acidification is already widely practiced for them. Recommended addition measures from radiological and chemical literature include glass containers where possible, water filtration where possible, headspace minimization, light shielding, cold (4°C) storage and unfiltered water hold time of 28 days. Soil hold time may need to be shortened when water-logged, excessively sandy, or still adjusting to significant new contamination.

  14. Internationalization and Corporate Cash Holdings: Evidence from Brazil and Mexico

    Directory of Open Access Journals (Sweden)

    Newton Arata

    2015-05-01

    Full Text Available This research expands on previous studies of cash holdings and their determinants by studying the relationship between the degree of internationalization and the level of corporate cash holdings. We used a sample of nonfinancial, publicly traded companies from Brazil and Mexico for the period from 2006 to 2010. Our results suggest that the degree of internationalization is a determinant of cash, and that cash holding increases quadratically as the degree of company internationalization grows. Such behavior was different from the North American company studies in Chiang and Wang (2011. Similar to previous studies, both Trade-off and Pecking Order predictions are relevant control variables in our model. Finally, companies held less cash on their balance sheets during the precrisis period.

  15. Investasi: Komparasi Strategi Buy and Hold dengan Pendekatan Teknikal

    Directory of Open Access Journals (Sweden)

    Natica Ardani

    2012-01-01

    Full Text Available This research aims to analyse effectivity of technical analysis moving average compare to buy and hold strategy on index LQ-45 (as emerging market and S&P500 (as developed market. Using descriptive approach, this research analysed by metastock program with moving average exponential crossovers method. This research data samples use LQ45 and S&P500 from year 2001-2011. The findings of this research indicate that technical analysis more effective when economic situation on crisis (bearish. Whereas buy and hold strategy more effective on good economic condition (bullish. The results consistent for LQ-45 and S&P500.

  16. Holding Pressure and Its Influence on Quality in PIM Technology

    Directory of Open Access Journals (Sweden)

    Pavel Petera

    2012-01-01

    Full Text Available The PIM (powder injection molding process consists of several steps in which faults can occur. The quality of the part that is produced usually cannot be seen until the end of the process. It is therefore necessary to find a way to discover the fault earlier in the process. The cause of defects is very often “phase separation” (inhomogeneity in powder distribution, which can also be influenced by the holding pressure. This paper evaluates the powder distribution with a new method based on density measurement. Measurements were made using various holding pressure values.

  17. The Effect of Holding a Research Chair on Scientists’ Impact

    Energy Technology Data Exchange (ETDEWEB)

    Mirnezami, S.R.; Beaudry, C.

    2016-07-01

    This paper examines the effect of holding Canada Research Chair (CRC) on a scientist’s number of citations as a measure of research impact, based on an econometric analysis with combined data on Quebec scientists’ funding and journal publication. Using Generalized Least Square (GLS) method for regression analysis, the results show that holding either tier-1 or tier- 2 of CRC significantly and positively results in conducting research with higher impact. This finding, however, does not necessarily imply that the others are the lesser scientists. (Author)

  18. Promises, Promises, and Not a Job in Sight; Broke Ass State; The Violinist

    OpenAIRE

    Callahan, Lauren

    2011-01-01

    Promises, Promises, and Not a Job in Sight Abstract: This piece was produced in October 2010 and looked at California’s impending gubernatorial race. Jobs and the economy were a big issue in that campaign between Meg Whitman and Jerry Brown, and I set out to answer whether either candidate could provide the economic relief they were promising. Resources: Mathews, Joe and Mark Paul. California Crackup: How Reform Broke the Golden State and How We Can Fix It. 2010, University of California Pre...

  19. Astronaut Alan Bean holds Special Environmental Sample Container

    Science.gov (United States)

    1969-01-01

    Astronaut Alan L. Bean, lunar module pilot for the Apollo 12 lunar landing mission, holds a Special Environmental Sample Container filled with lunar soil collected during the extravehicular activity (EVA) in which Astronauts Charles Conrad Jr., commander, and Bean participated. Connrad, who took this picture, is reflected in the helmet visor of the lunar module pilot.

  20. Astronaut Dale Gardner holds up for sale sign after EVA

    Science.gov (United States)

    1984-01-01

    Astronaut Dale A. Gardner, having just completed the major portion of his second extravehicular activity (EVA) period in three days, holds up a 'for sale' sign. Astronaut Joseph P. ALlen IV, who also participated in the two EVA's, is reflected in Gardner's helmet visor. A portion of each of two recovered satellites is in the lower right corner, with Westar nearer Discovery's aft.

  1. Water holding capacity and swelling of casein hydrogels

    NARCIS (Netherlands)

    de Kruif, C; Anema, Skelte G.; Zhu, Changjun; Havea, Palatasa; Coker, Christina

    2015-01-01

    The water holding capacity of casein gels was investigated by measuring the swelling and de-swelling under a variety of conditions of temperature and salt concentration. Transglutaminase cross-linked sodium caseinate (15% w/w) gels will swell in good solvents or shrink in poor solvents until an equi

  2. Bending strength and holding power of tibial locking screws.

    Science.gov (United States)

    Lin, J; Lin, S J; Chiang, H; Hou, S M

    2001-04-01

    The bending strength and holding power of two types of specially designed tibial locking devices, a both-ends-threaded screw and an unthreaded bolt, were studied and compared with four types of commercially available tibial interlocking screws: Synthes, Howmedica, Richards, and Osteo AG. To test bending strength, the devices were inserted into a high molecular weight polyethylene tube and loaded at their midpoint by a materials testing machine to simulate a three point bending test. Single loading yielding strength and cyclic loading fatigue life were measured. To test holding power, the devices were inserted into tubes made of polyurethane foam, and their tips were loaded axially to measure pushout strength. The devices were tested with two different densities of foam materials and two different sizes of pilot holes. Insertion torque and stripping torque of the screws were measured first. Pushout tests were performed with each screw inserted with a tightness equal to 60% of its stripping torque. Test results showed that the yielding strength and the fatigue life were related closely to the inner diameter of the screws. The stripping torque predicted the pushout strength more reliably than did the insertion torque. All tested devices showed greater holding power in the foam with the higher density and with the smaller pilot holes. The both-ends-threaded screw had the highest pushout strength and a satisfactory fatigue strength. The unthreaded bolt had the highest fatigue strength but only fair holding power. Clinical studies of the use of these two types of locking devices are worthwhile.

  3. The myth of the early aviation patent hold-up

    DEFF Research Database (Denmark)

    Katznelson, Ron D; Howells, John

    2015-01-01

    The prevailing historical accounts of the formation of the U.S. aircraft “patent pool” in 1917 assume the U.S. Government necessarily intervened to alleviate a patent hold-up among private aircraft manufacturers. We show these accounts to be inconsistent with the historical facts. We show that de...

  4. Holding Period Return-Risk Modeling: Ambiguity in Estimation

    NARCIS (Netherlands)

    W.G.P.M. Hallerbach (Winfried)

    2003-01-01

    textabstractIn this paper we explore the theoretical and empirical problems of estimating average (excess) return and risk of US equities over various holding periods and sample periods. Our findings are relevant for performance evaluation, for estimating the historical equity risk premium, and for

  5. 31 CFR 223.16 - List of certificate holding companies.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false List of certificate holding companies. 223.16 Section 223.16 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL SERVICE, DEPARTMENT OF THE TREASURY FINANCIAL MANAGEMENT SERVICE SURETY COMPANIES DOING...

  6. 33 CFR 100.30 - Approval required for holding event.

    Science.gov (United States)

    2010-07-01

    ... event. 100.30 Section 100.30 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND... holding event. (a) An event for which application is required under § 100.15(a) shall be held only after approval of such event by the District Commander, except that applications referred to a State under § 100...

  7. 77 FR 32881 - Supervised Securities Holding Company Registration

    Science.gov (United States)

    2012-06-04

    ... 81 Supervised Securities Holding Company Registration AGENCY: Board of Governors of the Federal...'' or ``Act''), which permits nonbank companies that own at least one registered securities broker or dealer, and that are required by a foreign regulator or provision of foreign law to be subject to...

  8. Holding Period Return-Risk Modeling: Ambiguity in Estimation

    NARCIS (Netherlands)

    W.G.P.M. Hallerbach (Winfried)

    2003-01-01

    textabstractIn this paper we explore the theoretical and empirical problems of estimating average (excess) return and risk of US equities over various holding periods and sample periods. Our findings are relevant for performance evaluation, for estimating the historical equity risk premium, and for

  9. Great United Petroleum Holding Co Ltd Announced Its Establishment

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    @@ China's largest private petroleum group - the Great United Petroleum Holding Co., Ltd (GUPC) announced its establishment in Beijing on June 29th, marking that the private enterprises are moving from being decentralized to unification, China's private oil industry is entering on a new stage of development.

  10. Mixed Dominance and the Manner of Holding a Pencil.

    Science.gov (United States)

    Lovell, Virginia K.

    1982-01-01

    Reports on an informal study that revealed that a significant number of people who hold a pencil with two fingers and a thumb have mixed cerebral dominance, that more females than males have mixed dominance, and that those with mixed dominance tend to be more imaginative. (FL)

  11. U. S. Army Directory of Technical Information Holdings and Services.

    Science.gov (United States)

    Vincent, Dale L.

    The directory identifies 111 Army sources of technical information that include 2200 specialized subject areas. The sources are indexed by subject matter, and name of holding, so that a searcher can find a description of all available indexed Army information services, with details on scope and size of collections, services available, and means of…

  12. 31 CFR 316.5 - Limitation on holdings.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Limitation on holdings. 316.5 Section 316.5 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL SERVICE, DEPARTMENT OF THE TREASURY BUREAU OF THE PUBLIC DEBT OFFERING OF UNITED STATES SAVINGS BONDS, SERIES E §...

  13. Autophagy : Moving Benchside Promises to Patient Bedsides.

    Science.gov (United States)

    Belaid, Amine; Ndiaye, Papa Diogop; Filippakis, Harilaos; Roux, Jérémie; Röttinger, Éric; Graba, Yacine; Brest, Patrick; Hofman, Paul; Mograbi, Baharia

    2015-01-01

    Survival rates of patients with metastatic or recurrent cancers have remained virtually unchanged during the past 30 years. This fact makes the need for new therapeutic options even more urgent. An attractive option would be to target autophagy, an essential quality control process that degrades toxic aggregates, damaged organelles, and signaling proteins, and acts as a tumor suppressor pathway of tumor initiation. Conversely, other fascinating observations suggest that autophagy supports cancer progression, relapse, metastasis, dormancy and resistance to therapy. This review provides an overview of the contradictory roles that autophagy plays in cancer initiation and progression and discusses the promises and challenges of current strategies that target autophagy for cancer therapy.

  14. MEMORY AND PROMISE IN ARENDT AND NIETZSCHE

    Directory of Open Access Journals (Sweden)

    VANESSA LEMM

    2006-01-01

    Full Text Available This article investigates and compares the value and significance that Arendt and Nietzsche attribute to the role played by memory and by the promise in constituting the political and in safeguarding the freedom and plurality of human actionEste artículo compara el valor y el significado que Arendt y Nietzsche otorgan a la memoria y a la promesa para la constitución de lo político así como para la salvaguardia de la libertad y de la pluralidad humana

  15. The physiology and pathophysiology of human breath-hold diving.

    Science.gov (United States)

    Lindholm, Peter; Lundgren, Claes E G

    2009-01-01

    This is a brief overview of physiological reactions, limitations, and pathophysiological mechanisms associated with human breath-hold diving. Breath-hold duration and ability to withstand compression at depth are the two main challenges that have been overcome to an amazing degree as evidenced by the current world records in breath-hold duration at 10:12 min and depth of 214 m. The quest for even further performance enhancements continues among competitive breath-hold divers, even if absolute physiological limits are being approached as indicated by findings of pulmonary edema and alveolar hemorrhage postdive. However, a remarkable, and so far poorly understood, variation in individual disposition for such problems exists. Mortality connected with breath-hold diving is primarily concentrated to less well-trained recreational divers and competitive spearfishermen who fall victim to hypoxia. Particularly vulnerable are probably also individuals with preexisting cardiac problems and possibly, essentially healthy divers who may have suffered severe alternobaric vertigo as a complication to inadequate pressure equilibration of the middle ears. The specific topics discussed include the diving response and its expression by the cardiovascular system, which exhibits hypertension, bradycardia, oxygen conservation, arrhythmias, and contraction of the spleen. The respiratory system is challenged by compression of the lungs with barotrauma of descent, intrapulmonary hemorrhage, edema, and the effects of glossopharyngeal insufflation and exsufflation. Various mechanisms associated with hypoxia and loss of consciousness are discussed, including hyperventilation, ascent blackout, fasting, and excessive postexercise O(2) consumption. The potential for high nitrogen pressure in the lungs to cause decompression sickness and N(2) narcosis is also illuminated.

  16. Citicoline: update on a promising and widely available agent for neuroprotection and neurorepair.

    Science.gov (United States)

    Saver, Jeffrey L

    2008-01-01

    Choline precursors promote repair and growth of cell membranes and hold promise in a variety of neurologic diseases, including ischemic and hemorrhagic stroke. Citicoline, the most well-studied choline agent precursor, is widely prescribed throughout the world and recently became available in the United States as a dietary supplement. In experimental stroke models, citicoline conferred acute neuroprotection and enhanced neuroplasticity and neurorepair in the subacute period. Although individual human stroke trials have been inconclusive, meta-analysis of 10 trials enrolling 2279 patients suggests patients receiving citicoline had substantially reduced frequencies of death and disability. Reinvestigation of citicoline with modern neuroimaging and clinical trial methods are underway and will provide more definitive information regarding the mechanistic and clinical effects of this promising neurotherapeutic agent.

  17. The promise of mobile technologies and single case designs for the study of individuals in their natural environment.

    Science.gov (United States)

    Vilardaga, Roger; Bricker, Jonathan; McDonell, Michael

    2014-04-01

    Mobile technologies are growing rapidly around the world to broad demographics of society. These technologies hold great promise for their integration with Single Case Designs (SCDs) and the study of individuals in their natural environment. This paper discusses the theoretical, methodological and analytic implications of these tools for the advancement of the contextual behavioral etiology of behavioral disorders, and their remediation. We hope this paper will highlight the scientific advantages of combining mobile technologies and SCDs and encourage their adoption among CBS scientists.

  18. Indoles - A promising scaffold for drug development.

    Science.gov (United States)

    Sravanthi, T V; Manju, S L

    2016-08-25

    Generally, heterocycles occupy a prominent place in chemistry due to their wide range of applications in the fields of drug design, photochemistry, agrochemicals, dyes and so on. Among them, indole scaffolds have been found in most of the important synthetic drug molecules and paved a faithful way to develop effective targets. Privileged structures bind to multiple receptors with high affinity, thus aiding the development of novel biologically active compounds. Among the indole class of compounds, 2-arylindoles appear to be a most promising lead for drug development. The derivatives of 2-arylindoles exhibits antibacterial, anticancer, anti-oxidants, anti-inflammatory, anti-diabetic, antiviral, antiproliferative, antituberculosis activity, etc. This article would provide a clear knowledge on the wide-ranging biological activities of 2-arylindoles over the past two decades, which would be beneficial for the designing of more potent drug targets in order to compete with the existing drugs. Copyright © 2016 Elsevier B.V. All rights reserved.

  19. Autism: Pathophysiology and Promising Herbal Remedies.

    Science.gov (United States)

    Bahmani, Mahmoud; Sarrafchi, Amir; Shirzad, Hedayatollah; Rafieian-Kopaei, Mahmoud

    2016-01-01

    Autism is a comprehensive growth abnormality in which social skills, language, communication, and behavioral skills are developed with delay and as diversionary. The reasons for autism are unclear, but various theories of genetics, immunity, biological, and psychosocial factors have been proffered. In fact, autism is a complex disorder with distinct causes that usually co-occur. Although no medicine has been recognized to treat this disorder, pharmacological treatments can be effective in reducing its signs, such as self-mutilation, aggression, repetitive and stereotyped behaviors, inattention, hyperactivity, and sleeping disorders. Recently, complementary and alternative approaches have been considered to treat autism. Ginkgo biloba is one of the most effective plants with an old history of applications in neuropsychological disorders which recently is used for autism. The present review discusses the recent findings, pathophysiology, and etiology of autism and thereafter addresses the promising results of herbal remedies.

  20. The promise and peril of healthcare forecasting.

    Science.gov (United States)

    Wharam, J Frank; Weiner, Jonathan P

    2012-03-01

    Health plans and physician groups increasingly use sophisticated tools to predict individual patient outcomes. Such analytics will accelerate as US medicine enters the digital age. Promising applications of forecasting include better targeting of disease management as well as innovative patient care approaches such as personalized health insurance and clinical decision support systems. In addition, stakeholders will use predictions to advance their organizational agendas, and unintended consequences could arise. Forecasting-based interventions might have uncertain effectiveness, focus on cost savings rather than long-term health, or specifically exclude disadvantaged populations. Policy makers, health plans, and method developers should adopt strategies that address these concerns in order to maximize the benefit of healthcare forecasting on the long-term health of patients.

  1. Promising treatments of tomorrow for multiple sclerosis

    Directory of Open Access Journals (Sweden)

    Harrison Daniel

    2009-01-01

    Full Text Available The therapeutic options for multiple sclerosis are rapidly expanding. What was once seen as a disease with little hope for treatment is now a target of rapid drug development. Current therapies have demonstrated efficacy in limiting the impact of the disease, but none is fully effective in all patients. However, promising new treatments are on the horizon. In this review we will discuss potential novel immunomodulating drugs that are in advanced stages of investigation; these drugs include monoclonal antibodies, chimeric molecules, and oral therapies. The use of hematopoietic stem cells will also be discussed and, in addition, we will look farther ahead at possible novel targets for the development of new immunomodulatory or neuroprotective pharmaceuticals.

  2. Nanomedicine delivers promising treatments for rheumatoid arthritis.

    Science.gov (United States)

    Prasad, Leena Kumari; O'Mary, Hannah; Cui, Zhengrong

    2015-01-01

    An increased understanding in the pathophysiology of chronic inflammatory diseases, such as rheumatoid arthritis, reveals that the diseased tissue and the increased presence of macrophages and other overexpressed molecules within the tissue can be exploited to enhance the delivery of nanomedicine. Nanomedicine can passively accumulate into chronic inflammatory tissues via the enhanced permeability and retention phenomenon, or be surface conjugated with a ligand to actively bind to receptors overexpressed by cells within chronic inflammatory tissues, leading to increased efficacy and reduced systemic side-effects. This review highlights the research conducted over the past decade on using nanomedicine for potential treatment of rheumatoid arthritis and summarizes some of the major findings and promising opportunities on using nanomedicine to treat this prevalent and chronic disease.

  3. Underexploited tropical plants with promising economic value

    Energy Technology Data Exchange (ETDEWEB)

    1975-01-01

    The apparent advantages of staple plants over the minor tropical plants often result only from the disproportionate research attention they have been given. A world-wide inquiry resulted in a list of 400 promising but neglected species. The 36 most important species are described in compact monographs and concern cereals (Echinochloa turnerana, grain amaranths, quinua and Zosterea mazina), roots and tubers (Arrachacha, cocoyams and taro), vegetables (chaya, hearts of palms, wax gourd, winged bean), fruits (durian, mangosteen, naranjilla, pejibaye, pummelo, soursop, uvilla), oilseeds (babassu palm, buffalo gourd, Caryocar species, Hessenia polycarpa and jojoba), forage (Acacia albida, Brosimum alicastrum Cassia sturtii, saltbushes and tamarugo) and other crops (buriti palm, Calathea lutea, candelilla, guar, guayule, Paspalum vaginatum, ramie and Spirulina).

  4. Halopentacenes: Promising Candidates for Organic Semiconductors

    Institute of Scientific and Technical Information of China (English)

    DU Gong-He; REN Zhao-Yu; GUO Ping; ZHENG Ji-Ming

    2009-01-01

    We introduce polar substituents such as F, Cl, Br into pentacene to enhance the dissolubility in common organic solvents while retaining the high charge-carrier mobilities of pentacene. Geometric structures, dipole moments,frontier molecule orbits, ionization potentials and electron affinities, as well as reorganization energies of those molecules, and of pentacene for comparison, are successively calculated by density functional theory. The results indicate that halopentacenes have rather small reorganization energies (< 0.2 eV), and when the substituents are in position 2 or positions 2 and 9, they are polarity molecules. Thus we conjecture that they can easily be dissolved in common organic solvents, and are promising candidates for organic semiconductors.

  5. Review of Some Promising Fractional Physical Models

    CERN Document Server

    Tarasov, Vasily E

    2015-01-01

    Fractional dynamics is a field of study in physics and mechanics investigating the behavior of objects and systems that are characterized by power-law non-locality, power-law long-term memory or fractal properties by using integrations and differentiation of non-integer orders, i.e., by methods of the fractional calculus. This paper is a review of physical models that look very promising for future development of fractional dynamics. We suggest a short introduction to fractional calculus as a theory of integration and differentiation of non-integer order. Some applications of integro-differentiations of fractional orders in physics are discussed. Models of discrete systems with memory, lattice with long-range inter-particle interaction, dynamics of fractal media are presented. Quantum analogs of fractional derivatives and model of open nano-system systems with memory are also discussed.

  6. GOLD NANOPARTICLES: PROMISING AND POTENTIAL NANOMATERIAL

    Directory of Open Access Journals (Sweden)

    Madhuri Shringirishi*, S.K. Prajapati , Alok Mahor , Shashi Alok , Poonam Yadav and Amita Verma

    2013-11-01

    Full Text Available Gold nanoparticles (AuNPs have appeared as an attractive candidate for delivery of various drug molecules or considered as extraordinary molecular carriers for the targeting, intracellular trafficking and delivery of a huge array of biomolecules including DNA, RNA, proteins, peptides, drugs, genes and other molecules of therapeutic significance. Particularly gold nanoparticles have attracted intensive interest, because they are easily prepared, have low toxicity and can be readily attached to molecules of biological interest. More and more research shows that AuNPs-based technologies are becoming promising approaches in drug and gene delivery, liver targeting, brain targeting, cancer research and AIDS treatment. The present review focuses on synthesis and functionalization methods of GNPs, the past researchs and reviews about GNPs, their emerging applications and uses and their future prospects.

  7. Court rules insurer must honor its promise.

    Science.gov (United States)

    1998-10-01

    Monumental Life Insurance Co. has to pay more than $230,000 to a beneficiary whose partner died of AIDS, shortly after paying the monthly premium for a life insurance policy. Unaware of the health status of the policy holder, a representative from the insurance company granted coverage and gave the policy holder a written statement that showed the amount of coverage of the policy. After the death of the partner, the insurance company told the beneficiary that the amount of coverage promised was a mistake. The beneficiary sued, and it was ruled that the company's letter, and the payment of the monthly premium, constituted a contract that the insurance company was obligated to uphold.

  8. The Economic Promise of Delayed Aging.

    Science.gov (United States)

    Goldman, Dana

    2015-12-18

    Biomedicine has made enormous progress in the last half century in treating common diseases. However, we are becoming victims of our own success. Causes of death strongly associated with biological aging, such as heart disease, cancer, Alzheimer's disease, and stroke-cluster within individuals as they grow older. These conditions increase frailty and limit the benefits of continued, disease-specific improvements. Here, we show that a "delayed-aging" scenario, modeled on the biological benefits observed in the most promising animal models, could solve this problem of competing risks. The economic value of delayed aging is estimated to be $7.1 trillion over 50 years. Total government costs, including Social Security, rise substantially with delayed aging--mainly caused by longevity increases--but we show that these can be offset by modest policy changes. Expanded biomedical research to delay aging appears to be a highly efficient way to forestall disease and extend healthy life.

  9. Cobalt Derivatives as Promising Therapeutic Agents

    Science.gov (United States)

    Heffern, Marie C.; Yamamoto, Natsuho; Holbrook, Robert J.; Eckermann, Amanda L.; Meade, Thomas J.

    2013-01-01

    Inorganic complexes are versatile platforms for the development of potent and selective pharmaceutical agents. Cobalt possesses a diverse array of properties that can be manipulated to yield promising drug candidates. Investigations into the mechanism of cobalt therapeutic agents can provide valuable insight into the physicochemical properties that can be harnessed for drug development. This review presents examples of bioactive cobalt complexes with special attention to their mechanisms of action. Specifically, cobalt complexes that elicit biological effects through protein inhibition, modification of drug activity, and bioreductive activation are discussed. Insights gained from these examples reveal features of cobalt that can be rationally tuned to produce therapeutics with high specificity and improved efficacy for the biomolecule or pathway of interest. PMID:23270779

  10. 26 CFR 1.553-1 - Foreign personal holding company income.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 7 2010-04-01 2010-04-01 true Foreign personal holding company income. 1.553-1... TAX (CONTINUED) INCOME TAXES (CONTINUED) Foreign Personal Holding Companies § 1.553-1 Foreign personal holding company income. Foreign personal holding company income shall consist of the items defined...

  11. Simulation of assembling cargo-hold spaceship pallets

    Science.gov (United States)

    Du, Ruizhao; Wang, Pengfei; Wu, Qianru; Jing, Chenchen

    2017-06-01

    The pallet is the load-carrying body between cargo and cargo-hold cabin. Due to the narrow space of cargo-hold cabin, it is difficult for workers to operate. During the installation process of the pallet, it can easily collide with cabin. Based on the installation technology of the pallet, the assembly process of pallet is simulated and analyzed in this paper. The main installation process includes the lifting of pallet, the process of pallet entering the cabin and the assembling of separating device. In the simulation, the practicability of tooling, the standing position of operators, visibility and accessibility of operations are analyzed to determine the risk points in the installation process of pallet. According to the simulation results, feasibility of pallet installation is verified, space requirements for installation are given, and position requirements and posture requirements of workers in the operation process can also be achieved.

  12. Emulsifying salt increase stability of cheese emulsions during holding

    DEFF Research Database (Denmark)

    Hougaard, Anni Bygvrå; Sijbrandij, Anna G.; Varming, Camilla

    2015-01-01

    In cheese powder production, cheese is mixed and melted with water and emulsifying salt to form an emulsion (cheese feed) which is required to remain stable at 60°C for 1h and during further processing until spray drying. Addition of emulsifying salts ensures this, but recent demands for reduction...... of sodium and phosphate in foods makes production of cheese powder without or with minimal amounts of emulsifying salts desirable. The present work uses a centrifugation method to characterize stability of model cheese feeds. Stability of cheese feed with emulsifying salt increased with holding time at 60°C......, especially when no stirring was applied. No change in stability during holding was observed in cheese feeds without emulsifying salt. This effect is suggested to be due to continued exerted functionality of the emulsifying salt, possibly through reorganizations of the mineral balance....

  13. A distribution-free newsvendor problem with nonlinear holding cost

    Science.gov (United States)

    Pal, Brojeswar; Sankar Sana, Shib; Chaudhuri, Kripasindhu

    2015-05-01

    In this paper, we analyse a single-period newsvendor model to determine the optimal order quantity where the customers' balking occurs.This scenario occurs when the customers are opposed to buy a product for various reasons, such as decreasing quality of product, product is not as good as fresh when it reaches under a threshold level, etc. The model is investigated by assuming that the holding cost function depends on order quantity and the inventory level at which customer balking occurs depends on holding cost. The model allows partial backlogging and permits part of the backlogged shortages to turn into lost sales. We develop the model without taking any specific distributional form of demand, only assuming the mean and the variance of the distribution of demand. Finally, we illustrate the model by numerical examples and compare our distribution-free model with the specific distributional form of demand.

  14. The carbon holdings of northern Ecuador's mangrove forests

    CERN Document Server

    Hamilton, Stuart E; Borbor, Mercy; Millones, Marco

    2016-01-01

    Within a GIS environment, we combine field measures of mangrove diameter, mangrove species distribution, and mangrove density with remotely sensed measures of mangrove location and mangrove canopy cover to estimate the mangrove carbon holdings of northern Ecuador. We find that the four northern estuaries of Ecuador contain approximately 7,742,999 t (plus or minus 15.47 percent) of standing carbon. Of particular high carbon holdings are the Rhizophora mangle dominated mangrove stands found in-and-around the Cayapas-Mataje Ecological Reserve in northern Esmeraldas Province, Ecuador and certain stands of Rhizophora mangle in-and-around the Isla Corazon y Fragata Wildlife Refuge in central Manabi Province, Ecuador. Our field driven mangrove carbon estimate is higher than all but one of the comparison models evaluated. We find that basic latitudinal mangrove carbon models performed at least as well, if not better, than the more complex species based allometric models in predicting standing carbon levels. In additi...

  15. Legal Statement authorized by Veken Holding Group Co.,Ltd.

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    According to Patent Law of the People’s Republic of China,Implementing Regulations of the Patent Law of the People’s Republic of China,and other laws and regulations,Zhejiang Heyi Law Office has been authorized by Veken Holding Group Co.,Ltd.("Veken Group")to announce the statement as below to protect the legal rights of the patentee.

  16. Clinical and Laboratory Findings of Patients with Breath Holding Spells

    Directory of Open Access Journals (Sweden)

    Özlem Özdemir

    2009-09-01

    Full Text Available Aim: The aim of this prospective study was to evaluate the clinical characteristics; physical findings, cardiological, hematological and neurological problems; treatment approaches; and the prognosis of children with breath holding spells.Materials and Method: Seventhy patients were included in this study. All patients were evaluated with detailed history and physical examination. Complete blood count, serum iron and iron binding capacity were studied; cardiological (telecardiography, electrocardiography, if necessary echocardiography and event recorder and neurological investigations (electroencephalography were done during the admission. Patients with iron deficiency anemia and iron deficiency were treated with ferrous sulphate orally. In patients with normal hematological values, no medication was used. After a two-month treatment period patients underwent control hematological evaluation. Frequency of the spells, age of disappearance of spells (defined as 6 months without spells, disappearance ratios between the three groups were compared. Results: The percentage of cyanotic, palloric and mixt type of breath holding spells of 70 patients included in the study were 67.1, 14.3 and 18.6, respectively. It was determined that psychogenic factors played a role in 77.1% of our patients. There were iron deficiency anemia in 39 (55.7%, iron deficiency in 12 (17.2% and normal hematological parameters in 19 (27.1% of 70 patients. The QTc values were normal in all of them. EEG’s were normal in 56 (80%, dysrhythmic in 11 (15.7% and pathologic in (4.3%. There was a positive family history of breath holding spells in 44.3% of those with breath holding spells. Conclusion: We determined that there was a correlation between the iron levels and the frequency of spells. The lower the iron levels the higher the frequency of spells. There was a dramatic decrease of 92% in spells with low doses of iron supplementation especially in the anemic group. (Journal of

  17. PCV Holding: Who’s next? - Planning the Succession

    OpenAIRE

    Ramos, Beatriz Maria Venâncio

    2014-01-01

    This paper is a case study on a family business – PCV Holding – established in Mozambique. Having survived three generations and experiencing one of the most intense periods of growth, a tough issue emerges which is capable of compromising the future of the business: The Succession -How to transfer the management and ownership to the next generation while ensuring a fair process. Through several meetings with the board members and owners, I had the opportunity to understand the business an...

  18. International Reserve Holdings with Sovereign Risk and Costly Tax Collection

    OpenAIRE

    Aizenman, Joshua; Nancy P. Marion

    2003-01-01

    This paper analyzes the international reserve-holding behavior of developing countries. It shows that political-economy considerations modify the optimal reserve level determined by efficiency criteria. A country characterized by volatile output, inelastic demand for fiscal outlays, high tax collection costs and sovereign risk will want to accumulate international reserves as well as external debt. Efficiency considerations imply that reserves are optimal when the benefits they provide for in...

  19. Promise Neighborhoods: The Promise and Politics of Community Capacity Building as Urban School Reform

    Science.gov (United States)

    Horsford, Sonya Douglass; Sampson, Carrie

    2014-01-01

    The purpose of this inquiry is to consider how the U.S. Department of Education's Promise Neighborhoods (PNs) program can improve persistently low-achieving urban schools by making their "neighborhoods whole again" through community capacity building for education reform. As the "first federal initiative to put education at the…

  20. Dextran: A promising macromolecular drug carrier

    Directory of Open Access Journals (Sweden)

    Dhaneshwar Suneela

    2006-01-01

    Full Text Available Over the past three decades intensive efforts have been made to design novel systems able to deliver the drug more effectively to the target site. The ongoing intense search for novel and innovative drug delivery systems is predominantly a consequence of the well-established fact that the conventional dosage forms are not sufficiently effective in conveying the drug compound to its site of action and once in the target area, in releasing the active agent over a desired period of time. The potential use of macromolecular prodrugs as a means of achieving targeted drug delivery has attracted considerable interest in recent years. Macromolecules such as antibodies, lipoproteins, lectins, proteins, polypeptides, polysaccharides, natural as well as synthetic polymers offer potential applicabilities as high molecular weight carriers for various therapeutically active compounds. Dextrans serve as one of the most promising macromolecular carrier candidates for a wide variety of therapeutic agents due to their excellent physico-chemical properties and physiological acceptance. The present contribution attempts to review various features of the dextran carrier like its source, structural and physico-chemical characteristics, pharmacokinetic fate and its applications as macromolecular carrier with special emphasis on dextran prodrugs.

  1. The Renewed Promise of Medical Informatics.

    Science.gov (United States)

    van Bemmel, J H; McCray, A T

    2016-05-20

    The promise of the field of Medical Informatics has been great and its impact has been significant. In 1999, the Yearbook editors of the International Medical Informatics Association (IMIA) - also the authors of the present paper - sought to assess this impact by selecting a number of seminal papers in the field, and asking experts to comment on these articles. In particular, it was requested whether and how the expectations, represented by these papers, had been fulfilled since their publication several decades earlier. Each expert was also invited to comment on what might be expected in the future. In the present paper, these areas are briefly reviewed again. Where did these early papers have an impact and where were they not as successful as originally expected? It should be noted that the extraordinary developments in computer technology observed in the last two decades could not have been foreseen by these early researchers. In closing, some of the possibilities and limitations of research in medical informatics are outlined in the context of a framework that considers six levels of computer applications in medicine and health care. For each level, some predictions are made for the future, concluded with thoughts on fruitful areas for ongoing research in the field.

  2. Medical big data: promise and challenges.

    Science.gov (United States)

    Lee, Choong Ho; Yoon, Hyung-Jin

    2017-03-01

    The concept of big data, commonly characterized by volume, variety, velocity, and veracity, goes far beyond the data type and includes the aspects of data analysis, such as hypothesis-generating, rather than hypothesis-testing. Big data focuses on temporal stability of the association, rather than on causal relationship and underlying probability distribution assumptions are frequently not required. Medical big data as material to be analyzed has various features that are not only distinct from big data of other disciplines, but also distinct from traditional clinical epidemiology. Big data technology has many areas of application in healthcare, such as predictive modeling and clinical decision support, disease or safety surveillance, public health, and research. Big data analytics frequently exploits analytic methods developed in data mining, including classification, clustering, and regression. Medical big data analyses are complicated by many technical issues, such as missing values, curse of dimensionality, and bias control, and share the inherent limitations of observation study, namely the inability to test causality resulting from residual confounding and reverse causation. Recently, propensity score analysis and instrumental variable analysis have been introduced to overcome these limitations, and they have accomplished a great deal. Many challenges, such as the absence of evidence of practical benefits of big data, methodological issues including legal and ethical issues, and clinical integration and utility issues, must be overcome to realize the promise of medical big data as the fuel of a continuous learning healthcare system that will improve patient outcome and reduce waste in areas including nephrology.

  3. The promise of Lean in health care.

    Science.gov (United States)

    Toussaint, John S; Berry, Leonard L

    2013-01-01

    An urgent need in American health care is improving quality and efficiency while controlling costs. One promising management approach implemented by some leading health care institutions is Lean, a quality improvement philosophy and set of principles originated by the Toyota Motor Company. Health care cases reveal that Lean is as applicable in complex knowledge work as it is in assembly-line manufacturing. When well executed, Lean transforms how an organization works and creates an insatiable quest for improvement. In this article, we define Lean and present 6 principles that constitute the essential dynamic of Lean management: attitude of continuous improvement, value creation, unity of purpose, respect for front-line workers, visual tracking, and flexible regimentation. Health care case studies illustrate each principle. The goal of this article is to provide a template for health care leaders to use in considering the implementation of the Lean management system or in assessing the current state of implementation in their organizations. Copyright © 2013 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.

  4. Medical big data: promise and challenges

    Directory of Open Access Journals (Sweden)

    Choong Ho Lee

    2017-03-01

    Full Text Available The concept of big data, commonly characterized by volume, variety, velocity, and veracity, goes far beyond the data type and includes the aspects of data analysis, such as hypothesis-generating, rather than hypothesis-testing. Big data focuses on temporal stability of the association, rather than on causal relationship and underlying probability distribution assumptions are frequently not required. Medical big data as material to be analyzed has various features that are not only distinct from big data of other disciplines, but also distinct from traditional clinical epidemiology. Big data technology has many areas of application in healthcare, such as predictive modeling and clinical decision support, disease or safety surveillance, public health, and research. Big data analytics frequently exploits analytic methods developed in data mining, including classification, clustering, and regression. Medical big data analyses are complicated by many technical issues, such as missing values, curse of dimensionality, and bias control, and share the inherent limitations of observation study, namely the inability to test causality resulting from residual confounding and reverse causation. Recently, propensity score analysis and instrumental variable analysis have been introduced to overcome these limitations, and they have accomplished a great deal. Many challenges, such as the absence of evidence of practical benefits of big data, methodological issues including legal and ethical issues, and clinical integration and utility issues, must be overcome to realize the promise of medical big data as the fuel of a continuous learning healthcare system that will improve patient outcome and reduce waste in areas including nephrology.

  5. Acyl-homoserine lactone-based quorum sensing and quorum quenching hold promise to determine the performance of biological wastewater treatments: An overview.

    Science.gov (United States)

    Huang, Jinhui; Shi, Yahui; Zeng, Guangming; Gu, Yanling; Chen, Guiqiu; Shi, Lixiu; Hu, Yi; Tang, Bi; Zhou, Jianxin

    2016-08-01

    Quorum sensing (QS) is a communication process between cells, in which bacteria secrete and sense the specific chemicals, and regulate gene expression in response to population density. Quorum quenching (QQ) blocks QS system, and inhibits gene expression mediating bacterial behaviors. Given the extensive research of acyl-homoserine lactone (AHL) signals, existences and effects of AHL-based QS and QQ in biological wastewater treatments are being subject to high concern. This review summarizes AHL structure, synthesis mode, degradation mechanisms, analytical methods, environmental factors, AHL-based QS and QQ mechanisms. The existences and roles of AHL-based QS and QQ in biomembrane processes, activated sludge processes and membrane bioreactors are summarized and discussed, and corresponding exogenous regulation strategy by selective enhancement of AHL-based QS or QQ coexisting in biological wastewater treatments is suggested. Such strategies including the addition of AHL signals, AHL-producing bacteria as well as quorum quenching enzyme or bacteria can effectively improve wastewater treatment performance without killing or limiting bacterial survival and growth. This review will present the theoretical and practical cognition for bacterial AHL-based QS and QQ, suggest the feasibility of exogenous regulation strategies in biological wastewater treatments, and provide useful information to scientists and engineers who work in this field.

  6. Intranasal formulations: promising strategy to deliver vaccines.

    Science.gov (United States)

    Riese, Peggy; Sakthivel, Priya; Trittel, Stephanie; Guzmán, Carlos A

    2014-10-01

    The emergence of new diseases and the lack of efficient vaccines against numerous non-treatable pathogens require the development of novel vaccination strategies. To date, only a few mucosal vaccines have been approved for humans. This was in part due to i) the use of live attenuated vaccines, which are not suitable for certain groups of individuals, ii) safety concerns derived from implementation in humans of some mucosal vaccines, iii) the poor stability, absorption and immunogenicity of antigens delivered by the mucosal route and iv) the limited number of available technologies to overcome the bottlenecks associated with mucosal antigen delivery. Recent advances make feasible the development of efficacious mucosal vaccines with adequate safety profile. Thus, currently intranasal vaccines represent an attractive and valid alternative to conventional vaccines. The present review is focused on the potentials and limitations of market-approved intranasal vaccines and promising candidates undergoing clinical investigations. Furthermore, emerging strategies to overcome main bottlenecks including efficient breaching of the mucosal barrier and safety concerns by implementation of new adjuvants and delivery systems are discussed. The rational design of intranasal vaccines requires an in-depth understanding of the anatomic, physicochemical and barrier properties of the nasal mucosa, as well as the molecular mechanisms governing the activation of the local innate and adaptive immune system. This would provide the critical knowledge to establish effective approaches to deliver vaccine antigens across the mucosal barrier, supporting the stimulation of a long-lasting protective response at both mucosal and systemic levels. Current developments in the area of adjuvants, nanotechnologies and mucosal immunology, together with the identification of surface receptors that can be exploited for cell targeting and manipulating their physiological properties, will become instrumental

  7. Enantioselectivity of mass spectrometry: challenges and promises.

    Science.gov (United States)

    Awad, Hanan; El-Aneed, Anas

    2013-01-01

    With the fast growing market of pure enantiomer drugs and bioactive molecules, new chiral-selective analytical tools have been instigated including the use of mass spectrometry (MS). Even though MS is one of the best analytical tools that has efficiently been used in several pharmaceutical and biological applications, traditionally MS is considered as a "chiral-blind" technique. This limitation is due to the MS inability to differentiate between two enantiomers of a chiral molecule based merely on their masses. Several approaches have been explored to assess the potential role of MS in chiral analysis. The first approach depends on the use of MS-hyphenated techniques utilizing fast and sensitive chiral separation tools such as liquid chromatography (LC), gas chromatography (GC), and capillary electrophoresis (CE) coupled to MS detector. More recently, several alternative separation techniques have been evaluated such as supercritical fluid chromatography (SFC) and capillary electrochromatography (CEC); the latter being a hybrid technique that combines the efficiency of CE with the selectivity of LC. The second approach is based on using the MS instrument solely for the chiral recognition. This method depends on the behavioral differences between enantiomers towards a foreign molecule and the ability of MS to monitor such differences. These behavioral differences can be divided into three types: (i) differences in the enantiomeric affinity for association with the chiral selector, (ii) differences of the enantiomeric exchange rate with a foreign reagent, and (iii) differences in the complex MS dissociation behaviors of the enantiomers. Most recently, ion mobility spectrometry was introduced to qualitatively and quantitatively evaluate chiral compounds. This article provides an overview of MS role in chiral analysis by discussing MS based methodologies and presenting the challenges and promises associated with each approach.

  8. Resveratrol as promising natural radioprotector. A review.

    Science.gov (United States)

    Dobrzyńska, Małgorzata M

    2013-01-01

    Public feelings concerning radiation are still controversy. The main sources of trouble seems to be the failure nuclear power plant and danger of terroristic attack, which may cause temporally enhanced level of radiation leading to harmful health effects. Since radiation induced cellular damage is attributed primarily to harmful effect of free radicals, molecules with direct free radical scavenging properties are particularly promising as radiation modifiers/protectors, i.e. agents which present prior to or shortly after radiation exposure alter to response of tissues to radiation. Unfortunately, some of known radioprotectors are toxic at doses required for radioprotection. Resveratrol (RSV), an natural polyphenol is produced in several plants in response to injury, stress, bacteria or fungi infection, UV-irradiation and exposure to ozone. It is present in human diet i.e. in fruits and in wine. RSV is known for its antioxidant, anti-inflammatory, analgesic, antiviral, cardioprotective, neuroprotective and antiageing action and it has been shown to have chemopreventive effects with respect to several human disease such as cardiovascular disease, osteoporosis and gastric ulcers. Depending on the dose, RSV may act as antioxidant or as pro-oxidant. RSV improves sperm count and motility in rodents and prevent DNA damage caused by cryptopreservation of human sperm. Moreover, RSV acting with other agents, inhibits the toxic action of them. There are evidences that RSV is able to modulate the behavior of cells in response to radiation induced damage. Minimalization of radiation induced damage to somatic and germ cells by RSV might be useful in cancer therapy to prevent the damage to normal cells as well as in case of radiological accidents.

  9. Water addition, evaporation and water holding capacity of poultry litter.

    Science.gov (United States)

    Dunlop, Mark W; Blackall, Patrick J; Stuetz, Richard M

    2015-12-15

    Litter moisture content has been related to ammonia, dust and odour emissions as well as bird health and welfare. Improved understanding of the water holding properties of poultry litter as well as water additions to litter and evaporation from litter will contribute to improved litter moisture management during the meat chicken grow-out. The purpose of this paper is to demonstrate how management and environmental conditions over the course of a grow-out affect the volume of water A) applied to litter, B) able to be stored in litter, and C) evaporated from litter on a daily basis. The same unit of measurement has been used to enable direct comparison-litres of water per square metre of poultry shed floor area, L/m(2), assuming a litter depth of 5cm. An equation was developed to estimate the amount of water added to litter from bird excretion and drinking spillage, which are sources of regular water application to the litter. Using this equation showed that water applied to litter from these sources changes over the course of a grow-out, and can be as much as 3.2L/m(2)/day. Over a 56day grow-out, the total quantity of water added to the litter was estimated to be 104L/m(2). Litter porosity, water holding capacity and water evaporation rates from litter were measured experimentally. Litter porosity decreased and water holding capacity increased over the course of a grow-out due to manure addition. Water evaporation rates at 25°C and 50% relative humidity ranged from 0.5 to 10L/m(2)/day. Evaporation rates increased with litter moisture content and air speed. Maintaining dry litter at the peak of a grow-out is likely to be challenging because evaporation rates from dry litter may be insufficient to remove the quantity of water added to the litter on a daily basis.

  10. Voltage holding optimization of the MITICA electrostatic accelerator

    Energy Technology Data Exchange (ETDEWEB)

    Pilan, N., E-mail: nicola.pilan@igi.cnr.it [Consorzio RFX, Associazione EURATOM-ENEA sulla Fusione, Corso Stati Uniti 4, I-35127 Padova (Italy); Bettini, P. [Consorzio RFX, Associazione EURATOM-ENEA sulla Fusione, Corso Stati Uniti 4, I-35127 Padova (Italy); DII, Università di Padova, v. Gradenigo 6/A, I-35131 Padova (Italy); De Lorenzi, A. [Consorzio RFX, Associazione EURATOM-ENEA sulla Fusione, Corso Stati Uniti 4, I-35127 Padova (Italy); Specogna, R. [DIEGM, Università di Udine, v. delle Scienze 208, I-33100 Udine (Italy)

    2013-10-15

    Highlights: ► A set of electrostatic analyses of the region surrounding the MITICA electrostatic accelerator has been carried out. ► The distribution of the breakdown probability of the system has been calculated. ► The analyses have allowed identifying the weak point of the system to address the future design optimizations. -- Abstract: Two Heating Neutral Beam Injectors (H-NBI) are planned to be installed in ITER with a total delivered heating power of 33 MW [1]. The main parameters are: 870 kV acceleration voltage with 46 A beam current for hydrogen beam, and 1 MV voltage with 40 A current for deuterium beam. The voltage holding in the 1 MV ITER Neutral Beam Accelerator is recognized to be one of the most critical issues for long pulse (3600 s) beam operation, due to the complex electrostatic structure formed by electrodes polarized at different potentials immersed in vacuum or low-pressure gas. As a matter of fact, the system shall work in a p × d range at the left of the Paschen curve where the classical Townsend breakdown criterion is no longer valid. The voltage holding is governed by the mechanism of the long gap insulation in high vacuum, not yet well consolidated from the physical point of view. This paper is aimed to describe the optimization of the voltage holding capability for MITICA electrostatic accelerator. The results of this analysis will constitute the input for the probabilistic model [3] which is adopted to predict the breakdown probability by means of 2D analyses of the multi electrode – multi voltage system.

  11. Cognitive-motor interference while grasping, lifting and holding objects.

    Directory of Open Access Journals (Sweden)

    Erwan Guillery

    Full Text Available In daily life, object manipulation is usually performed concurrently to the execution of cognitive tasks. The aim of the present study was to determine which aspects of precision grip require cognitive resources using a motor-cognitive dual-task paradigm. Eighteen healthy participants took part in the experiment, which comprised two conditions. In the first condition, participants performed a motor task without any concomitant cognitive task. They were instructed to grip, lift and hold an apparatus incorporating strain gauges allowing a continuous measurement of the force perpendicular to each contact surface (grip force, GF as well as the total tangential force applied on the object (load force, LF. In the second condition, participants performed the same motor task while concurrently performing a cognitive task consisting in a complex visual search combined with counting. In the dual-task condition, we found a significant increase in the duration of the preload phase (time between initial contact of the fingers with the apparatus and onset of the load force, as well as a significant increase of the grip force during the holding phase, indicating that the cognitive task interfered with the initial force scaling performed during the preload phase and the fine-tuning of grip force during the hold phase. These findings indicate that these aspects of precision grip require cognitive resources. In contrast, other aspects of the precision grip, such as the temporal coupling between grip and load forces, were not affected by the cognitive task, suggesting that they reflect more automatic processes. Taken together, our results suggest that assessing the dynamic and temporal parameters of precision grip in the context of a concurrent cognitive task may constitute a more ecological and better-suited tool to characterize motor dysfunction in patients.

  12. HIV aspartyl protease inhibitors as promising compounds against Candida albicans

    Institute of Scientific and Technical Information of China (English)

    André; Luis; Souza; dos; Santos

    2010-01-01

    Cells of Candida albicans(C.albicans) can invade humans and may lead to mucosal and skin infections or to deep-seated my coses of almost all inner organs,especially in immunocompromised patients.In this context,both the host immune status and the ability of C.albicans to modulate the expression of its virulence factors are relevant aspects that drive the candidal susceptibility or resistance;in this last case,culminating in the establishment of successful infection knownas candidiasis.C.albicans possesses a potent arma-mentarium consisting of several virulence moleculesthat help the fungal cells to escape of the host immuneresponses.There is no doubt that the secretion of aspartyl-type proteases,designated as Saps,are one of the major virulence attributes produced by C.albicans cells,since these hydrolytic enzymes participate in a wide range of fungal physiological processes as well as in different facets of the fungal-host interactions.For these reasons,Saps clearly hold promise as new potential drug targets.Corroborating this hypothesis,the introduction of new anti-human immunodeficiency virus drugs of the as party l protease inhibitor-type(HIV PIs) have emerged as new agents for the inhibition of Saps.The introduction of HIV PIs has revolutionized the treatment of HIV disease,reducing opportunistic infections,especially candidiasis.The attenuation of candidal infections in HIV-infected individuals might not solely have resulted from improved immunological status,but also as a result of direct inhibition of C.albicans Saps.In this article,we review updates on the beneficial effects of HIV PIs against the human fungal pathogen C.albicans,focusing on the effects of these compounds on Sap activity,growth behavior,morphological architecture,cellular differentiation,fungal adhesion to animal cells and abiotic materials,modulation of virulence factors,experimental candidiasis infection,and their synergistic actions with classical antifungal agents.

  13. Deep inspiration breath-hold radiotherapy for lung cancer

    DEFF Research Database (Denmark)

    Josipovic, Mirjana; Persson, Gitte F; Bangsgaard, Jens P

    2016-01-01

    OBJECTIVE: We investigated the impact of deep inspiration breath-hold (DIBH) and tumour baseline shifts on image quality and registration uncertainty in image-guided DIBH radiotherapy (RT) for locally advanced lung cancer. METHODS: Patients treated with daily cone beam CT (CBCT)-guided free...... ≤2 mm did not affect the CBCT image quality considerably. CONCLUSION: DIBH CBCT improved image quality and reduced registration uncertainty in the craniocaudal direction in image-guided RT of locally advanced lung cancer. Baseline shifts ≤2 mm in DIBH during CBCT acquisition did not affect image...

  14. Henan Non-ferrous Holding Company Set Up in Henan

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    <正>Henan Non-ferrous Holding Co.(hereinafter referred to as Henan Non-ferrous),an enterprise set up under the joint effort of 3 enterprises with state-owned assets namely Shenhuo Group,Yichuan Power and Yulian Group,has started its operation under tight schedule.The focus of the current operation is acquisition,for which a number of alumina and aluminum processing enterprises are on the list of Henan Non-ferrous.China Nonferrous Metals Monthly reported this news at our last issue,now we try to analysis more details behind the decision.

  15. Energy cost and optimisation in breath-hold diving.

    Science.gov (United States)

    Trassinelli, M

    2016-05-07

    We present a new model for calculating locomotion costs in breath-hold divers. Starting from basic mechanics principles, we calculate the work that the diver must provide through propulsion to counterbalance the action of drag, the buoyant force and weight during immersion. Compared to those in previous studies, the model presented here accurately analyses breath-hold divers which alternate active swimming with prolonged glides during the dive (as is the case in mammals). The energy cost of the dive is strongly dependent on these prolonged gliding phases. Here we investigate the length and impacts on energy cost of these glides with respect to the diver characteristics, and compare them with those observed in different breath-hold diving species. Taking into account the basal metabolic rate and chemical energy to propulsion transformation efficiency, we calculate optimal swim velocity and the corresponding total energy cost (including metabolic rate) and compare them with observations. Energy cost is minimised when the diver passes through neutral buoyancy conditions during the dive. This generally implies the presence of prolonged gliding phases in both ascent and descent, where the buoyancy (varying with depth) is best used against the drag, reducing energy cost. This is in agreement with past results (Miller et al., 2012; Sato et al., 2013) where, when the buoyant force is considered constant during the dive, the energy cost was minimised for neutral buoyancy. In particular, our model confirms the good physical adaption of dolphins for diving, compared to other breath-hold diving species which are mostly positively buoyant (penguins for example). The presence of prolonged glides implies a non-trivial dependency of optimal speed on maximal depth of the dive. This extends previous findings (Sato et al., 2010; Watanabe et al., 2011) which found no dependency of optimal speed on dive depth for particular conditions. The energy cost of the dive can be further

  16. Cash Holdings and Leverage of German Listed Firms

    DEFF Research Database (Denmark)

    Rapp, Marc Steffen; Killi, Andreas Maximilian

    2016-01-01

    We examine cash holdings and leverage levels of German listed (non-financial and non-utility) firms. We document a secular increase in cash ratios over the last twenty years (1992–2011), reducing the net debt book leverage ratio for the average sample firm close to zero. Using prediction models...... firms are associated with measures of uncertainty faced by firms. Our results suggest that German firms have increased (reduced) their cash (net debt leverage) levels over time in order to adopt more precautionary financial policies....

  17. La Holding Estrategia Fiscal Para las Empresas Familiares

    OpenAIRE

    Rosa Hilda Hernandez Sandoval; Sandra Patricia de la Garza Cienfuegos; Laura Leticia Gaona Tamez

    2010-01-01

    La presente investigación se realizó en Monclova, Coah., en el año 2011 y tiene por objeto constituir una empresa holding para obtener beneficios fiscales sin caer en la evasión o elusión fiscal, esta alternativa permite controlar desde la cúspide a las demás empresas subsidiarias que han sido creadas. Los resultados muestran que existen en México 4,862 empresas familiares que consolidan para efectos fiscales, las cuales se encuentran integradas en 422 grupos. En este régimen de fiscalización...

  18. Public Utility Holding Company Act of 1935: 1935--1992

    Energy Technology Data Exchange (ETDEWEB)

    1993-01-15

    This report provides an economic and legislative history and analysis of the Public Utilities Holding Company Act (PUHCA) of 1935. This Act was substantially amended for the first time in 1992 by passage of the Energy Policy Act (EPACT). The report also includes a discussion of the issues which led to the amendment of PUHCA and projections of the impact of these changes on the electric industry. The report should be of use to Federal and State regulators, trade associations, electric utilities, independent power producers, as well as decision-makers in Congress and the Administration.

  19. The Design of Reactor Internals Hold-Down Spring

    Directory of Open Access Journals (Sweden)

    Guohong Xue

    2016-01-01

    Full Text Available Hold down spring(HDS, clamped between the upper support plate flange and the core barrel flange inside a pressurized reactor vessel, is used to provide a downward force to keep the core barrel stable and from being lifted off from the vessel ledge during reactor normal operation. Spring designer used to think under certain extreme operating conditions, the spring could be lifted off from the ledge because the spring is not stiff enough to prevent the “lift-off”. Therefore, the spring was designed as stiff as it practically can be. However, finite element study indicated that the magnitude of preload is a strong function of friction coefficient. To find the magnitude of the friction coefficient, a series of tests were conducted on 1/10 scale hold down spring samples of three different spring designs. From the test results, it was found that the friction coefficient increases rapidly as the number of loading cycles increases. This implies that the spring preload would increase rapidly during plant operation. Therefore, it is concluded that, because of the strong frictional effect, not only the current design is more than adequate, but also should be made even softer.

  20. A Haptic Guided Robotic System for Endoscope Positioning and Holding.

    Science.gov (United States)

    Cabuk, Burak; Ceylan, Savas; Anik, Ihsan; Tugasaygi, Mehtap; Kizir, Selcuk

    2015-01-01

    To determine the feasibility, advantages, and disadvantages of using a robot for holding and maneuvering the endoscope in transnasal transsphenoidal surgery. The system used in this study was a Stewart Platform based robotic system that was developed by Kocaeli University Department of Mechatronics Engineering for positioning and holding of endoscope. After the first use on an artificial head model, the system was used on six fresh postmortem bodies that were provided by the Morgue Specialization Department of the Forensic Medicine Institute (Istanbul, Turkey). The setup required for robotic system was easy, the time for registration procedure and setup of the robot takes 15 minutes. The resistance was felt on haptic arm in case of contact or friction with adjacent tissues. The adaptation process was shorter with the mouse to manipulate the endoscope. The endoscopic transsphenoidal approach was achieved with the robotic system. The endoscope was guided to the sphenoid ostium with the help of the robotic arm. This robotic system can be used in endoscopic transsphenoidal surgery as an endoscope positioner and holder. The robot is able to change the position easily with the help of an assistant and prevents tremor, and provides a better field of vision for work.

  1. In which Financial Markets do Mutual Fund Theorems hold true?

    CERN Document Server

    Schachermayer, Walter; Taflin, Erik

    2007-01-01

    The Mutual Fund Theorem (MFT) is considered in a general semimartingale financial market S with a finite time horizon T, where agents maximize expected utility of terminal wealth. It is established that: 1) Let N be the wealth process of the num\\'eraire portfolio (i.e. the optimal portfolio for the log utility). If any path-independent option with maturity T written on the num\\'eraire portfolio can be replicated by trading \\emph{only} in N, then the (MFT) holds true for general utility functions, and the num\\'eraire portfolio may serve as mutual fund. This generalizes Merton's classical result on Black-Scholes markets. Conversely, under a supplementary weak completeness assumption, we show that the validity of the (MFT) for general utility functions implies the same replicability property for options on the num\\'eraire portfolio described above. 2) If for a given class of utility functions (i.e. investors) the (MFT) holds true in all complete Brownian financial markets S, then all investors use the same utili...

  2. Clinical Efficacy of Piracetam on Breath Holding Spells in Children

    Directory of Open Access Journals (Sweden)

    F. Ashrafzadeh

    2004-07-01

    Full Text Available Breath holding spells (BHS is a type of syncope in children , most commonly encontered in the early years of life. Although these athacks don't damage the brain , if these are frequent or prolonged cause , parents frighten , so physician should intervent. In this study we evaluated clinical efficacy of piracetam on B.H.S of children in Mashhad Ghaem Hospital during 2001-2002.In this double blind placebo control study , piracetam or placebo on a randomized basis was administered to children with 40 mg/kg/day in 2 divided doses for 2 months. From the 41 children that were enrolled , 21 cases received piracetam and 20 cases received placebo. Parents denoted the numbers of spells two months before and two months after taking drug. Control of breath holding spells were observed in 90.5% of patients in the group taking piracetam as compared with 40% in the group taking placebo (P = 0.002. Of the all patients 10 cases had iron deficiency anemia so they had taken elemental Fe too. The side effects were the same in these two groups. The results of this study indicated that piracetam was efficient for the treatment of children with B.H.S without greater incidence adverse effects than placebo.

  3. Functional stability limits while holding loads in various positions.

    Science.gov (United States)

    Holbein, M A; Redfern, M S

    1997-05-01

    Stability of the body during manual material handling is an important issue in the prevention of falls and over-exertion injuries. This research investigated stability limits while standing and holding loads in different positions relative to the body. Theoretically, the stability region is the full base of support defined by the perimeter of the foot contact area. However, the functional stability region may be smaller. The purpose of this study was to locate functional stability limits with respect to the base of support. Fifteen male subjects leaned as far as possible in four directions in the sagittal and frontal planes. Their center of gravity location at these extremes determined the stability limit. The results showed that functional stability limits reached only about 60% of the distance to the maximum base of support limits under the conditions of this study. The sway angles reached at the stability limits averaged 9.2 degrees anteroposteriorly and 15.3 degrees laterally. External load positions which lowered the center of gravity of the body-and-load system extended those stability limits. This study provides a postural stability perspective of load-holding which may be applied in establishing safe lifting and reach limits.

  4. [Absorbable coronary stents. New promising technology].

    Science.gov (United States)

    Erbel, Raimund; Böse, Dirk; Haude, Michael; Kordish, Igor; Churzidze, Sofia; Malyar, Nasser; Konorza, Thomas; Sack, Stefan

    2007-06-01

    Coronary stent implantation started in Germany 20 years ago. In the beginning, the progress was very slow and accelerated 10 years later. Meanwhile, coronary stent implantation is a standard procedure in interventional cardiology. From the beginning of permanent stent implantation, research started to provide temporary stenting of coronary arteries, first with catheter-based systems, later with stent-alone technology. Stents were produced from polymers or metal. The first polymer stent implantation failed except the Igaki-Tamai stent in Japan. Newly developed absorbable polymer stents seem to be very promising, as intravascular ultrasound (IVUS) and optical coherence tomography have demonstrated. Temporary metal stents were developed based on iron and magnesium. Currently, the iron stent is tested in peripheral arteries. The absorbable magnesium stent (Biotronik, Berlin, Germany) was tested in peripheral arteries below the knee and meanwhile in the multicenter international PROGRESS-AMS (Clinical Performance and Angiographic Results of Coronary Stenting with Absorbable Metal Stents) study. The first magnesium stent implantation was performed on July 30, 2004 after extended experimental testing in Essen. The magnesium stent behaved like a bare-metal stent with low recoil of 5-7%. The stent struts were absorbed when tested with IVUS. Stent struts were not visible by fluoroscopy or computed tomography (CT) as well as magnetic resonance imaging (MRI). That means, that the magnesium stent is invisible and therefore CT and MRI can be used for imaging of interventions. Only using micro-CT the stent struts were visible. The absorption process could be demonstrated in a patient 18 days after implantation due to suspected acute coronary syndrome, which was excluded. IVUS showed a nice open lumen. Stent struts were no longer visible, but replaced by tissue indicating the previous stent location. Coronary angiography after 4 months showed an ischemia-driven target lesion

  5. Prosecuting the Leaders: Promises, Politics and Practicalities

    Directory of Open Access Journals (Sweden)

    Robert Cryer

    2009-02-01

    Full Text Available Given recent developments in relation to the prosecution of international crimes,  it might be thought that one of the last bastions of sovereignty has been breached, and international criminal law has not only entrenched itself in international law. Indeed further to this, it has assumed a supranational position that stands entirely above States, promising justice for all and as a trump card over depredations committed in the name of State sovereignty. After all, Charles Taylor from Liberia is standing trial before the Special Court for Sierra Leone, Slobodan Milošević only escaped judgment by the International Criminal Tribunal for the former

  6. Results of Hg speciation testing on MCU strip effluent hold tank (SEHT) and decontaminated salt solution hold tank (DSSHT) materials

    Energy Technology Data Exchange (ETDEWEB)

    Bannochie, C. J. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

    2015-09-17

    The Savannah River National Laboratory (SRNL) was tasked with preparing and shipping samples for Hg speciation by Eurofins Frontier Global Sciences, Inc. in Seattle, WA on behalf of the Savannah River Remediation (SRR) Mercury Task Team.i,ii The tenth shipment of samples was designated to include Modular Caustic Side Solvent Extraction Unit (MCU) Strip Effluent Hold Tank (SEHT) and MCU Decontaminated Salt Solution Hold Tank (DSSHT) materials from processing Salt Batch 7b. The MCU SEHT (MCU-15-722) and DSSHT (MCU-15-709) samples were pulled on June 15, 2015. All MCU samples were received at SRNL on June 16, 2015. The DSSHT sample was moved the same day to refrigeration, while the SEHT sample was placed in the Shielded Cells. On July 9, 2015 it was opened and an aliquot diluted 1:100 with Eurofins deionized water and a portion of the diluted sample transferred to a Teflon® bottle prior to moving it to refrigeration that same day. All samples were kept in the dark and refrigerated until final dilutions were prepared for shipment to Eurofins.

  7. Ten years of Dutch loss compensation regime for holding and financing companies

    NARCIS (Netherlands)

    Bobeldijk, A.C.P.; Braeken, B.

    2014-01-01

    Dutch holding and financing companies are subject to a specific tax loss compensation regime, the so-called holding company loss rule. In short, the purpose of this rule is the prevention of the compensation of losses resulting from holding and financing activities with profits from operational acti

  8. 26 CFR 53.4943-2 - Imposition of tax on excess business holdings of private foundations.

    Science.gov (United States)

    2010-04-01

    ... foundation described in section 4946(a)(1)(H), a questionnaire asking such persons to list all holdings... constructively held by F. The questionnaire asks each such person to list the holdings in such enterprises of any... his family, had an interest). The questionnaire asks that constructive holdings be listed only...

  9. 17 CFR 450.3 - Exemption for holdings subject to fiduciary standards.

    Science.gov (United States)

    2010-04-01

    ... TREASURY REGULATIONS UNDER TITLE II OF THE GOVERNMENT SECURITIES ACT OF 1986 CUSTODIAL HOLDINGS OF GOVERNMENT SECURITIES BY DEPOSITORY INSTITUTIONS § 450.3 Exemption for holdings subject to fiduciary... the Office of Thrift Supervision governing the holding of government securities in a...

  10. Measurement of Gas Hold-up Profiles in Stirred Tank Reactors by Gamma Ray Attenuation Technique

    NARCIS (Netherlands)

    Parasu Veera, U.; Patwardhan, A.W.; Joshi, J.B.

    2001-01-01

    Gas hold-up is one of the most important hydrodynamic characteristics that is needed for performance estimation, design and scale-up of reactors. The performance of large-scale reactors can be reliably evaluated by measuring the gas hold-up in such reactors. In the present work, local gas hold-up in

  11. 26 CFR 1.556-3 - Illustration of computation of undistributed foreign personal holding company income.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 7 2010-04-01 2010-04-01 true Illustration of computation of undistributed foreign personal holding company income. 1.556-3 Section 1.556-3 Internal Revenue INTERNAL REVENUE SERVICE... Holding Companies § 1.556-3 Illustration of computation of undistributed foreign personal holding...

  12. 21 CFR 111.465 - What requirements apply to holding reserve samples of dietary supplements?

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false What requirements apply to holding reserve samples... Distributing § 111.465 What requirements apply to holding reserve samples of dietary supplements? (a) You must hold reserve samples of dietary supplements in a manner that protects against contamination...

  13. 12 CFR 225.122 - Bank holding company ownership of mortgage companies.

    Science.gov (United States)

    2010-01-01

    ...) Regulations Financial Holding Companies Interpretations § 225.122 Bank holding company ownership of mortgage... Federal law or (2) as comprised within the concept of “such incidental powers as shall be necessary to... section 4 of the Act is to confine a bank holding company's activities to the management and control of...

  14. 78 FR 17155 - Standards for the Growing, Harvesting, Packing, and Holding of Produce for Human Consumption...

    Science.gov (United States)

    2013-03-20

    ... Growing, Harvesting, Packing, and Holding of Produce for Human Consumption; Correction AGENCY: Food and..., harvesting, packing, and holding of produce, meaning fruits and vegetables grown for human consumption. FDA..., Harvesting, Packing, and Holding of Produce for Human Consumption.'' The document published with several...

  15. 78 FR 24692 - Standards for the Growing, Harvesting, Packing, and Holding of Produce for Human Consumption...

    Science.gov (United States)

    2013-04-26

    ... Growing, Harvesting, Packing, and Holding of Produce for Human Consumption; Extension of Comment Periods..., Harvesting, Packing, and Holding of Produce for Human Consumption'' that appeared in the Federal Register of... Growing, Harvesting, Packing, and Holding of Produce for Human Consumption'' with a 120-day comment period...

  16. 26 CFR 301.6501(f)-1 - Personal holding company tax.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 18 2010-04-01 2010-04-01 false Personal holding company tax. 301.6501(f)-1... Collection § 301.6501(f)-1 Personal holding company tax. If a corporation which is a personal holding company... time during the last half of such taxable year, more than 50 percent in value of the...

  17. 76 FR 79190 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2011-12-21

    ..., California 94105-1579: 1. Private Bancorp of America, Inc., La Jolla, California; to become a bank holding... Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C...

  18. 26 CFR 1.897-2 - United States real property holding corporations.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 9 2010-04-01 2010-04-01 false United States real property holding corporations... property holding corporations. (a) Purpose and scope. This section provides rules regarding the definition and consequences of U.S. real property holding corporation status. U.S. real property...

  19. 12 CFR 574.8 - Qualified stock issuances by undercapitalized savings associations or holding companies.

    Science.gov (United States)

    2010-01-01

    ... stock by the acquiring savings and loan holding company. (5) The entire consideration for the stock issued is paid in cash by the acquiring savings and loan holding company. (6) At the time of the stock issuance, each savings association subsidiary of the acquiring savings and loan holding company (other...

  20. 46 CFR 154.1210 - Hold space, void space, cofferdam, and spaces containing cargo piping.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Hold space, void space, cofferdam, and spaces containing... Design, Construction and Equipment Cargo Area: Mechanical Ventilation System § 154.1210 Hold space, void space, cofferdam, and spaces containing cargo piping. (a) Each hold space, void space, cofferdam,...

  1. China will Hold Seminar to Greet the World Standards Day

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    @@ Here comes 2004, the 35th session of the World Standards Day. The theme of this session is"Standards Connect the World", which is precisely a good turning point not only for the domestic economy to connect rails gradually with international, but also for national government to consummate and strengthen the standardization management system, to advance standardization work, and to raise the standardization level, after China's entrance into the World Trade Organization. Therefore, when the 35th session of the World Standards Day is arriving, sponsored by the SAC (Standardization Administration of China) and organized by CAS (China Association for Standardization), China will hold a seminar on October 14 in the Great Hall of the People.

  2. DOES UNCOVERED INTEREST RATE PARITY HOLD IN TURKEY?

    Directory of Open Access Journals (Sweden)

    Ozcan Karahan

    2012-01-01

    Full Text Available Most of the earlier empirical studies focusing on developed countries failed to give evidence in favor of the Uncovered Interest Rate Parity (UIP. After intensive financial liberalization processes and mostly preferred free exchange rate regimes, a new area of research starts to involve the investigation whether UIP holds for developing economies differently. Accordingly, we tested the UIP for Turkey’s monthly interest rate and exchange rate data between 2002 and 2011. We run conventional regressions in the form of Ordinary Least Squares (OLS and used a simple Generalized Autoregressive Conditional Heteroskedasticity (GARCH analysis. The empirical results of both methods do not support the validity of UIP for Turkey. Thus, together with most of the earlier empirical studies focusing on developed countries and detecting the invalidity of UIP, we can argue that the experience of Turkey and developed economies are not different.

  3. Experimental determination of bone cortex holding power of orthopedic screw

    Directory of Open Access Journals (Sweden)

    Bolliger Neto Raul

    1999-01-01

    Full Text Available Cylindrical specimens of bone measuring 15 mm in diameter were obtained from the lateral cortical layer of 10 pairs of femurs and tibias. A central hole 3.2 mm in diameter was drilled in each specimen. The hole was tapped, and a 4.5 mm cortical bone screw was inserted from the outer surface. The montage was submitted to push-out testing up to a complete strip of the bone threads. The cortical thickness and rupture load were measured, and the shear stress was calculated. The results were grouped according to the bone segment from which the specimen was obtained. The results showed that bone cortex screw holding power is dependent on the bone site. Additionally, the diaphyseal cortical bone tissue is both quantitatively and qualitatively more resistant to screw extraction than the metaphyseal tissue.

  4. High hydrostatic pressure processing: a promising nonthermal technology to inactivate viruses in high-risk foods.

    Science.gov (United States)

    Lou, Fangfei; Neetoo, Hudaa; Chen, Haiqiang; Li, Jianrong

    2015-01-01

    Foodborne outbreaks of viral origin have become increasingly a serious public health concern. High-pressure processing (HPP), a nonthermal technology, has come to the forefront for food processing given its minimal effects on food quality. Recent studies have revealed encouraging results for the inactivation of several human viruses by HPP. This review provides comprehensive information on the use of HPP to eliminate viruses in model systems and foods. We address the influences of various parameters, including pressure level, holding time, pH, temperature, and food matrix on the efficacy of pressure inactivation of viruses, as well as insight into the mechanisms for inactivation of enveloped and nonenveloped viruses. HPP is a promising technology for mitigating virus contamination of foods, thus it is essential to identify the optimal parameters for enhancing virus inactivation while ensuring sensory and nutritional quality retention of foods.

  5. In Vitro Gamete Differentiation from Pluripotent Stem Cells as a Promising Therapy for Infertility.

    Science.gov (United States)

    Mouka, Aurélie; Tachdjian, Gérard; Dupont, Joëlle; Drévillon, Loïc; Tosca, Lucie

    2016-04-01

    Generation of gametes derived in vitro from pluripotent stem cells holds promising prospects for future reproductive applications. Indeed, it provides information on molecular and cellular mechanisms underlying germ cell (GC) development and could offer a new potential treatment for infertility. Great progress has been made in derivation of gametes from embryonic stem cells, despite ethical issues. Induced pluripotent stem cells (iPSCs) technology allows the reprogramming of a differentiated somatic cell, possibly emanating from the patient, into a pluripotent state. With the emergence of iPSCs, several studies created primordial GC stage to mature gamete-like cells in vitro in mice and humans. Recent findings in GC derivation suggest that in mice, functional gametes can be generated in vitro. This strengthens the idea that it might be possible in the future to generate functional human sperm and oocytes from pluripotent stem cells in culture.

  6. De Novo Human Cardiac Myocytes for Medical Research: Promises and Challenges

    Science.gov (United States)

    Hamel, Veronique; Cheng, Kang; Liao, Shudan; Lu, Aizhu; Zheng, Yong; Chen, Yawen; Xie, Yucai

    2017-01-01

    The advent of cellular reprogramming technology has revolutionized biomedical research. De novo human cardiac myocytes can now be obtained from direct reprogramming of somatic cells (such as fibroblasts), from induced pluripotent stem cells (iPSCs, which are reprogrammed from somatic cells), and from human embryonic stem cells (hESCs). Such de novo human cardiac myocytes hold great promise for in vitro disease modeling and drug screening and in vivo cell therapy of heart disease. Here, we review the technique advancements for generating de novo human cardiac myocytes. We also discuss several challenges for the use of such cells in research and regenerative medicine, such as the immature phenotype and heterogeneity of de novo cardiac myocytes obtained with existing protocols. We focus on the recent advancements in addressing such challenges.

  7. Gold nanoparticle layer: a promising platform for ultra-sensitive cancer detection.

    Science.gov (United States)

    Zhou, Feng; Yuan, Lin; Wang, Hongwei; Li, Dan; Chen, Hong

    2011-03-15

    Developing new technologies applicable to the sensitive detection of cancer in its early stages has always been attractive in diagnosis. A stable gold nanoparticle layer (GNPL)-modified high-binding ELISA plate was obtained via chemical plating and was proven to be more efficient in binding proteins while maintaining their activity. GNPL-based ELISA for the representative biomarker carcinoembryonic antigen (CEA) demonstrated that GNPL markedly amplified the ELISA signal and significantly improved the limit of detection (LOD). Antithrombin detection further confirms the effectiveness and universality of this GNPL-based platform. The entire assay procedure is simple and low in cost and does not require special facilities. All these virtues indicate that this GNPL platform holds great promise in clinical applications for the early diagnosis of cancer.

  8. COMMENTARY: THE PROMISE OF DIGITAL SCHOLARSHIP IN SLA RESEARCH AND LANGUAGE PEDAGOGY

    Directory of Open Access Journals (Sweden)

    Sally Sieloff Magnan

    2007-02-01

    Full Text Available Although digital scholarship is now well established in academia, there is no consensus about how it should be evaluated for tenure and promotion. Is digital publication acceptable as a way to disseminate research? Is the digital medium appropriate for conducting research? To what degree does creating digital materials--from research instruments to pedagogical materials--advance knowledge and thereby constitute scholarship? Recent calls for open access to scholarship (i.e., free publication and dissemination through digital media (see Chanier, 2007 are stimulating a debate that hinges on just such questions. In that debate, departments holding traditional views hesitate to recognize digital media as scholarship while others hold that digital media promises to enrich scholarly exchanges. In 2001, the Modern Language Association entered the controversy by offering its Guidelines for Evaluating Work with Digital Media in the Modern Languages (MLA, 2001. These Guidelines are the work of the Committee on Information Technology, formerly the MLA Committee on Computers and Emerging Technologies in Teaching and Research. They aim to help departments achieve an informed perspective on this new scholarly medium. In this commentary, I offer additional thoughts to the debate by considering (a how digital media necessitates a redefinition of scholarship in second language acquisition (SLA research and language pedagogy, (b what criteria might be used in evaluating digital scholarship, and (c how digital media enhances and accelerates SLA scholarship beyond the possibilities of print publication.

  9. Extending emotion and decision-making beyond the laboratory: The promise of palliative care contexts.

    Science.gov (United States)

    Ferrer, Rebecca A; Padgett, Lynne; Ellis, Erin M

    2016-08-01

    Although laboratory-based research on emotion and decision-making holds the distinct advantage of rigorous experimental control conditions that allow causal inferences, the question of how findings in a laboratory generalize to real-world settings remains. Identifying ecologically valid, real-world opportunities to extend laboratory findings is a valuable means of advancing this field. Palliative care-or care intended to provide relief from serious illness and aging-related complications during treatment or at the end of life-provides a particularly rich opportunity for such work. Here, we present an overview of palliative care, summarize existing research on emotion and palliative care decision-making, highlight challenges associated with conducting such research, outline examples of collaborative projects leveraging palliative care as a context for generating fundamental knowledge about emotion and decision-making, and describe the resources and collaborations necessary to conduct this type of research. In sum, palliative care holds unique promise as an emotionally laden context in which to answer fundamental questions about emotion and decision-making that extends our theoretical understanding of the role of emotion in high-stakes decision-making while simultaneously generating knowledge that can improve palliative care implementation. (PsycINFO Database Record

  10. 12 CFR 502.26 - How does OTS calculate the semi-annual assessment for savings and loan holding companies?

    Science.gov (United States)

    2010-01-01

    ...-site supervision of a noncomplex, low risk savings and loan holding company structure. OTS will... company is the registered holding company at the highest level of ownership in a holding company structure, unless OTS designates another savings and loan holding company in the holding company structure. OTS...

  11. Phase-Type Models of Channel-Holding Times in Cellular Communication Systems

    DEFF Research Database (Denmark)

    Christensen, Thomas Kaare; Nielsen, Bo Friis; Iversen, Villy Bæk

    2004-01-01

    In this paper, we derive the distribution of the channel-holding time when both cell-residence and call-holding times are phase-type distributed. Furthermore, the distribution of the number of handovers, the conditional channel-holding time distributions, and the channel-holding time when cell re...... residence times are correlated are derived. All distributions are of phase type, making them very general and flexible. The channel-holding times are of importance in performance evaluation and simulation of cellular mobile communication systems....

  12. Financial claims and product market competition: An explanation for permitting banks to hold equity in firms

    Directory of Open Access Journals (Sweden)

    Pao Shin-Heng

    2008-01-01

    Full Text Available This paper examines financial claims for lending if banks are permitted to hold equity in productive firms. We demonstrate that in situations where an oligopolistic product market has relatively high competition, e.g., quasi-competitive behavior, equity holding by banks is likely to do little damage. However, where the product market has relatively high collusion, e.g., corporative behavior, equity holding by banks are very unlikely to hold equity in firms. Our findings provide an alternative argument that lifting the Glass-Steagall Act restricting banks from holding equity in firms should give little cause for concern.

  13. Maximum holding endurance time: Effects of load and load's center of gravity height.

    Science.gov (United States)

    Lee, Tzu-Hsien

    2015-01-01

    Manual holding task is a potential risk to the development of musculoskeletal injuries since it is prone to induce localized muscle fatigue. Maximum holding endurance time is a significant parameter for the design of manual holding task. This study aimed to examine the effects of load and load's COG height on maximum holding endurance time. Fifteen young and healthy males were recruited as participants. A factorial design was used to examine the effects of load and load's COG height on maximum holding endurance time. Four levels of load (15% , 30% , 45% and 60% of the participant's maximum holding capacity) and two levels of load's COG height in box (0 cm and 40 cm high from the handle position) were examined. Maximum holding endurance time decreased with increasing load and/or increasing load's COG height. The effect of load's COG height on maximum holding endurance time decreased with increasing load. Load, load's COG height, and the interaction of load and load's COG height significantly affected maximum holding endurance time. Practitioners should realize the effects of load, load's COG height, and the interaction of load and load's COG height on maximum holding endurance time when setting the working conditions of holding tasks.

  14. Development and the Temporality of its Exchange. How an Eastern Yucatec Village Made Cash Transfer Promises Accountable

    Directory of Open Access Journals (Sweden)

    Andrés Dapuez

    2016-09-01

    Full Text Available This paper explores how three temporalities of exchange amend the reception of cash transfers for development in a village in Eastern Yucatan, Mexico. Based on participant observation and in-depth interviews of recipients of cash transfers from Procampo and Oportunidades, this study reveals that ritual promising functions as a means of temporal regulation in most transactions of this sort, and that the recipients hold their government accountable for promises and commitments regarding cash transfers. In assessing the temporal ranges and effectiveness of these transfers by alluding to previous stipulations that sustain the exchange and make it understandable and bearable as a promise, the people in this village consider the objectives of the Procampo and Oportunidades programs to be implausible. Accountability with respect to the long-term effects of these transfers is not, however, based only on local impressions of a state that procrastinates in its “engagement” with peasants. As the timetable established for the accumulation of human capital also exceeds the time limits of responsible promising, these cash transfer programs cannot be evaluated in terms of their fulfilled or unfulfilled promises.

  15. Does EVA performance evaluation improve the value of cash holdings? Evidence from China

    Institute of Scientific and Technical Information of China (English)

    Yongjian; Shen; Lei; Zou; Donghua; Chen

    2015-01-01

    This paper investigates the influence of the economic value added(EVA)performance evaluation,issued in 2010 by the State-owned Assets Supervision and Administration Commission of the State Council,on the value of the cash holdings of central state-owned enterprises(CSOEs).We find that EVA performance evaluation has some influence on the overinvestment of CSOE cash holdings and significantly increases the value of CSOE cash holdings compared with the cash holdings of local state-owned enterprises.The greater value of CSOE cash holdings derives from underinvestment modification and overinvestment restraint.The value of cash holdings increases more for companies with better accounting performance.Thus,the EVA performance evaluation policy increases CSOE efficiency.This study contributes to the emerging literature related to cash holdings and the economic consequences of the EVA performance evaluation policy.It expands the literature related to investor protection in countries experiencing economic transition.

  16. Does EVA performance evaluation improve the value of cash holdings? Evidence from China

    Directory of Open Access Journals (Sweden)

    Yongjian Shen

    2015-09-01

    Full Text Available This paper investigates the influence of the economic value added (EVA performance evaluation, issued in 2010 by the State-owned Assets Supervision and Administration Commission of the State Council, on the value of the cash holdings of central state-owned enterprises (CSOEs. We find that EVA performance evaluation has some influence on the overinvestment of CSOE cash holdings and significantly increases the value of CSOE cash holdings compared with the cash holdings of local state-owned enterprises. The greater value of CSOE cash holdings derives from underinvestment modification and overinvestment restraint. The value of cash holdings increases more for companies with better accounting performance. Thus, the EVA performance evaluation policy increases CSOE efficiency. This study contributes to the emerging literature related to cash holdings and the economic consequences of the EVA performance evaluation policy. It expands the literature related to investor protection in countries experiencing economic transition.

  17. ENVIRONMENTAL SUSTAINABILITY OF FAMILY-OWNED AGRICULTURAL HOLDINGS IN THE PODLASKIE VOIVODESHIP

    Directory of Open Access Journals (Sweden)

    Zofia Kołoszko-Chomentowska

    2015-09-01

    Full Text Available The subject of this paper is environmental sustainability assessment of agricultural holdings in the Podlaskie voivodeship, participating in the Farm Accountancy Data Network (FADN in the years 2007–2012. The assessment was conducted based on agro-ecological indicators and environmental burden (material pressure. The analysis was conducted according to a classification into agricultural holding types: field crops, dairy cattle, and mixed holdings. The factor with the strongest impact on the agro-ecological sustainability of the studied agricultural holdings was the holding type. Field crop and mixed holdings achieved more favorable environmental sustainability indicators. Holdings specializing in dairy cattle breeding pose a threat to the natural environment due to their excessive number of livestock.

  18. SU-E-J-62: Breath Hold for Left-Sided Breast Cancer: Visually Monitored Deep Inspiration Breath Hold Amplitude Evaluated Using Real-Time Position Management

    Energy Technology Data Exchange (ETDEWEB)

    Conroy, L; Quirk, S; Smith, WL [The University of Calgary, Calgary, AB (Canada); Tom Baker Cancer Centre, Calgary, AB (Canada); Yeung, R; Phan, T [The University of Calgary, Calgary, AB (Canada); Hudson, A [Tom Baker Cancer Centre, Calgary, AB (Canada)

    2015-06-15

    Purpose: We used Real-Time Position Management (RPM) to evaluate breath hold amplitude and variability when gating with a visually monitored deep inspiration breath hold technique (VM-DIBH) with retrospective cine image chest wall position verification. Methods: Ten patients with left-sided breast cancer were treated using VM-DIBH. Respiratory motion was passively collected once weekly using RPM with the marker block positioned at the xiphoid process. Cine images on the tangent medial field were acquired on fractions with RPM monitoring for retrospective verification of chest wall position during breath hold. The amplitude and duration of all breath holds on which treatment beams were delivered were extracted from the RPM traces. Breath hold position coverage was evaluated for symmetric RPM gating windows from ± 1 to 5 mm centered on the average breath hold amplitude of the first measured fraction as a baseline. Results: The average (range) breath hold amplitude and duration was 18 mm (3–36 mm) and 19 s (7–34 s). The average (range) of amplitude standard deviation per patient over all breath holds was 2.7 mm (1.2–5.7 mm). With the largest allowable RPM gating window (± 5 mm), 4 of 10 VM-DIBH patients would have had ≥ 10% of their breath hold positions excluded by RPM. Cine verification of the chest wall position during the medial tangent field showed that the chest wall was greater than 5 mm from the baseline in only 1 out of 4 excluded patients. Cine images verify the chest wall/breast position only, whether this variation is acceptable in terms of heart sparing is a subject of future investigation. Conclusion: VM-DIBH allows for greater breath hold amplitude variability than using a 5 mm gating window with RPM, while maintaining chest wall positioning accuracy within 5 mm for the majority of patients.

  19. Dual job holding practitioners in Bangladesh: an exploration.

    Science.gov (United States)

    Gruen, Reinhold; Anwar, Raqibul; Begum, Tahmina; Killingsworth, James R; Normand, Charles

    2002-01-01

    This paper analyses the system of financial and non-financial incentives underlying job preferences of doctors in Bangladesh who work both in government health services and in private practice. The study is based on a survey of 100 government-employed doctors with private practice, across different levels of care and geographical areas. In-depth interviews were carried out in a sub-sample of 28 respondents. The study explores the beliefs and attitudes towards the arrangements of joint private/public practice, establishes profiles of fee levels and earnings and examines the options to change the incentive system in a way that ensures an increased involvement of dual job holding practitioners in the priority areas of care. Consultation fees were Tk120 on average (range Tk20-300) and found to be correlated with the qualification of the practice owner and the type of service offered. A majority of the respondents reported at least to double their government income by engaging in private practice. Significant predictors of total income included the number of patients seen in private practice (p=0.000), employment in a secondary or tertiary care facility (p=0.001) and ownership of premises for private practice (p=0.033). Age was found to be marginally significant (p=0.084). No association was found between total income and specialisation, private practice costs, level of government salary or a degree from abroad. The data suggest that doctors have adopted individual strategies to accommodate the advantages of both government employment and private practice in their career development, thus maximising benefit from the incentives provided to them e.g. status of a government job, and minimising opportunity costs of economic losses e.g. lower salaries. Commitment to government services was found to be greater among doctors in primary health care who reported they would give up private practice if paid a higher salary. Among doctors in secondary and tertiary care, the

  20. Three-dimensional imaging of hold baggage for airport security

    Science.gov (United States)

    Kolokytha, S.; Speller, R.; Robson, S.

    2014-06-01

    This study describes a cost-effective check-in baggage screening system, based on "on-belt tomosynthesis" (ObT) and close-range photogrammetry, that is designed to address the limitations of the most common system used, conventional projection radiography. The latter's limitations can lead to loss of information and an increase in baggage handling time, as baggage is manually searched or screened with more advanced systems. This project proposes a system that overcomes such limitations creating a cost-effective automated pseudo-3D imaging system, by combining x-ray and optical imaging to form digital tomograms. Tomographic reconstruction requires a knowledge of the change in geometry between multiple x-ray views of a common object. This is uniquely achieved using a close range photogrammetric system based on a small network of web-cameras. This paper presents the recent developments of the ObT system and describes recent findings of the photogrammetric system implementation. Based on these positive results, future work on the advancement of the ObT system as a cost-effective pseudo-3D imaging of hold baggage for airport security is proposed.

  1. Role of cerebral blood flow in extreme breath holding

    Directory of Open Access Journals (Sweden)

    Bain Anthony R.

    2016-01-01

    Full Text Available The role of cerebral blood flow (CBF on a maximal breath-hold (BH in ultra-elite divers was examined. Divers (n = 7 performed one control BH, and one BH following oral administration of the non-selective cyclooxygenase inhibitor indomethacin (1.2 mg/kg. Arterial blood gases and CBF were measured prior to (baseline, and at BH termination. Compared to control, indomethacin reduced baseline CBF and cerebral delivery of oxygen (CDO2 by about 26% (p < 0.01. Indomethacin reduced maximal BH time from 339 ± 51 to 319 ± 57 seconds (p = 0.04. In both conditions, the CDO2 remained unchanged from baseline to the termination of apnea. At BH termination, arterial oxygen tension was higher following oral administration of indomethacin compared to control (4.05 ± 0.45 vs. 3.44 ± 0.32 kPa. The absolute increase in CBF from baseline to the termination of apnea was lower with indomethacin (p = 0.01. These findings indicate that the impact of CBF on maximal BH time is likely attributable to its influence on cerebral H+ washout, and therefore central chemoreceptive drive to breathe, rather than to CDO2.

  2. Model reduction for experimental thermal characterization of a holding furnace

    Science.gov (United States)

    Loussouarn, Thomas; Maillet, Denis; Remy, Benjamin; Dan, Diane

    2017-09-01

    Vacuum holding induction furnaces are used for the manufacturing of turbine blades by loss wax foundry process. The control of solidification parameters is a key factor for the manufacturing of these parts. The definition of the structure of a reduced heat transfer model with experimental identification through an estimation of its parameters is required here. Internal sensors outputs, together with this model, can be used for assessing the thermal state of the furnace through an inverse approach, for a better control. Here, an axisymmetric furnace and its load have been numerically modelled using FlexPDE, a finite elements code. The internal induction heat source as well as the transient radiative transfer inside the furnace are calculated through this detailed model. A reduced lumped body model has been constructed to represent the numerical furnace. The model reduction and the estimation of the parameters of the lumped body have been made using a Levenberg-Marquardt least squares minimization algorithm, using two synthetic temperature signals with a further validation test.

  3. Holding-side influences on infant's view of mother's face.

    Science.gov (United States)

    Hendriks, Angélique W; van Rijswijk, Mariëlle; Omtzigt, David

    2011-11-01

    Recently we found that adult children whose mothers had had a right-arm preference for holding infants have a reduced left bias for recognising faces, suggesting that they are less well right-hemisphere lateralised for perceiving faces. One possible explanation of this finding is that early visual exposure to faces is suboptimal for right-held infants. To test this idea, we asked mothers to pick up a doll with an inbuilt camera in its face and to start bottle-feeding it. The results showed that less was visible of the face of mothers who held the doll on their right arm in comparison to those who held the doll on their left arm: From the right arm, the mother's left half of the face was less visible when the mothers were looking up and their right half of the face was less visible when they were looking at the doll. These results suggest that right-held infants receive suboptimal information from faces. Because early face exposure is important for face-processing development, the suboptimal face exposure probably experienced by right-held infants may have consequences for their ability to recognise faces and facial emotion later in life.

  4. Life on hold: the experience of living with neuromyelitis optica.

    Science.gov (United States)

    Mutch, Kerry; Methley, Abigail; Moore, Phil; Jacob, Anu

    2014-01-01

    Neuromyelitis optica (NMO) is a rare autoimmune condition characterised by acute relapses of optic neuritis and extensive transverse myelitis. The aim of this qualitative study was to develop an improved understanding of the experiences of people living with NMO. Fifteen participants completed a semi-structured interview and data were interpreted using a constant comparative method. Participants were recruited from the Northern UK NMO Service. Five major themes were identified: diagnosis and treatment, symptoms, adjustment, identity and support. Results suggest NMO is a difficult condition to live with due to the unpredictability of relapses and accrued disability of visual or spinal symptoms occurring with each relapse. Poor vision, reduced mobility, bladder dysfunction and pain affected participants' independence and experience of living with NMO. Participants reported that during relapse and recovery they would "put their life on hold". They identified the importance of periods of stability to enable them to adjust to their condition and therefore aim for "normality" of life that they believed was comparable to their peers. Implications for Rehabilitation Disability due to NMO has a major impact on an individual's life, abilities and identity. Timely treatment of relapse is essential to reduce or prevent disability. Health care professionals need to coordinate care locally and nationally. Multi-disciplinary work is vital to promote adjustment, coping strategies and support for people living with NMO.

  5. Normative perils and promises of food health branding

    DEFF Research Database (Denmark)

    Anker, Thomas Boysen

    The paper identifies and describes normative perils and promises that may crop up in relation to branding of foods on the value og health......The paper identifies and describes normative perils and promises that may crop up in relation to branding of foods on the value og health...

  6. Nanocellular polymer foams as promising high performance thermal insulation materials

    NARCIS (Netherlands)

    Liu, S.; Duvigneau, J.; Vancso, G.J.

    2015-01-01

    Low density, nanocellular polymer nanocomposite foams are considered as a promising new class of materials with many promising applications, for example to passively enhance the energy efficiency of buildings. This paper discusses recent developments in this field of polymer materials science. Parti

  7. Read my lips: The case against election promises

    NARCIS (Netherlands)

    Haan, M.A.; Los, B.; Onderstal, S.; Riyanto, Y.E.

    2008-01-01

    We study a model in which politicians differ in their ability to im- plement some policy. In an election, candidates make binding promises regarding the plans they will implement. These serve as a signal of true ability. In equilibrium, candidates make overambitious promises. The candidate with the

  8. SU-E-J-223: A BOLD Contrast Imaging Sequence to Evaluate Oxygenation Changes Due to Breath Holding for Breast Radiotherapy: A Pilot Study

    Energy Technology Data Exchange (ETDEWEB)

    Adamson, J; Chang, Z; Cai, J; Palta, M; Horton, J; Yin, F; Blitzblau, R [Duke University Medical Center, Durham, NC (United States)

    2015-06-15

    Purpose: To develop a robust MRI sequence to measure BOLD breath hold induced contrast in context of breast radiotherapy. Methods: Two sequences were selected from prior studies as candidates to measure BOLD contrast attributable to breath holding within the breast: (1) T2* based Gradient Echo EPI (TR/TE = 500/41ms, flip angle = 60°), and (2) T2 based Single Shot Fast Spin Echo (SSFSE) (TR/TE = 3000/60ms). We enrolled ten women post-lumpectomy for breast cancer who were undergoing treatment planning for whole breast radiotherapy. Each session utilized a 1.5T GE MRI and 4 channel breast coil with the subject immobilized prone on a custom board. For each sequence, 1–3 planes of the lumpectomy breast were imaged continuously during a background measurement (1min) and intermittent breath holds (20–40s per breath hold, 3–5 holds per sequence). BOLD contrast was quantified as correlation of changes in per-pixel intensity with the breath hold schedule convolved with a hemodynamic response function. Subtle motion was corrected using a deformable registration algorithm. Correlation with breath-holding was considered significant if p<0.001. Results: The percentage of the breast ROI with positive BOLD contrast measured by the two sequences were in agreement with a correlation coefficient of R=0.72 (p=0.02). While both sequences demonstrated areas with strong BOLD response, the response was more systematic throughout the breast for the SSFSE (T2) sequence (% breast with response in the same direction: 51.2%±0.7% for T2* vs. 68.1%±16% for T2). In addition, the T2 sequence was less prone to magnetic susceptibility artifacts, especially in presence of seroma, and provided a more robust image with little distortion or artifacts. Conclusion: A T2 SSFSE sequence shows promise for measuring BOLD contrast in the context of breast radiotherapy utilizing a breath hold technique. Further study in a larger patient cohort is warranted to better refine this novel technique.

  9. The Determinants of Corporate Cash Holdings- An Empirical study from UK Firms

    OpenAIRE

    Guo, Yi

    2013-01-01

    Cash holding is most important financial decision in the company management strategy. In this dissertation, the determinants of corporate cash holdings in UK non-financial publicly traded firms over the period from 2003 to 2012 are investigated. Our study finds that growth opportunities and cash flow and cash flow variability are positively associated with the level of corporate cash holdings, while firm size, leverage, net working capital, bank debt and dividend payment have negative impact ...

  10. Adults' preferences for side-of-hold as portrayed in paintings of the Madonna and Child.

    Science.gov (United States)

    Harris, Lauren Julius; Cardénas, Rodrigo Andrés; Spradlin, Michael P; Almerigi, Jason B

    2009-11-01

    Most women hold infants on their left side. They do the same when depicted in works of art. Does the latter accurately reflect the real-life bias, the artist's own aesthetic preference, or something else, such as the artist's handedness, sex, direction of attentional bias, or even the artist's own side-preference for holding infants? As a first step to finding out, we showed 272 young adults (85 men, 187 women) 20 pairs of paintings of the Madonna and Child, the original on one side, its mirror-reversal on the other, and asked which one they preferred. Along with assessing the effects of the variables already mentioned, we used equal numbers of paintings originally depicting left-holds and right-holds to control for the possible effects of differences between the paintings other than side-of-hold itself, such as in their colour scheme, background details, and the type of hold shown (e.g., cradle vs seated on lap). Each pair was presented twice, once with the original on the left, once on the right, for a total of 40 trials. Women and men alike more often preferred left-hold images, but the difference was significant only for women. Preferences were also stronger for original left-hold paintings than for the mirror-reversals of original right-hold paintings, suggesting that the originals differed in ways affecting preference beyond those we tried to control. Overall preference for left-hold images was enhanced when the images were on the viewer's left. As for the other variables, they were for the most part unrelated to preferences. The reasons for the preference thus remain unclear but it is evidently affected by multiple variables, with at least some clearly different from those affecting side-of-hold preferences of real mothers holding real infants.

  11. Stock Liquidity and Corporate Cash Holdings: Feedback and the Cash as Ammunition Hypothesis

    OpenAIRE

    Nyborg, Kjell G.; Wang, Zexi

    2013-01-01

    The paper contributes to the literature on corporate cash holdings by showing that there is a financial markets channel that affects corporations’ cash holdings. Leaning on the literature on stock price feedback to firm fundamentals, we advance the hypothesis that firms with more liquid stocks hold more cash, ceteris paribus, as ammunition to defend against negative cascades or stimulate positive ones. This contrasts with an alternative view that firms with more liquid stocks are less financi...

  12. Establishing an ISO 10001-based promise in inpatients care.

    Science.gov (United States)

    Khan, Mohammad Ashiqur Rahman; Karapetrovic, Stanislav

    2015-01-01

    The purpose of this paper is to explore ISO 10001:2007 in planning, designing and developing a customer satisfaction promise (CSP) intended for inpatients care. Through meetings and interviews with research participants, who included a program manager, unit managers and registered nurses, information about potential promises and their implementation was obtained and analyzed. A number of promises were drafted and one was finally selected to be developed as a CSP. Applying the standard required adaptation and novel interpretation. Additionally, ISO 10002:2004 (Clause 7) was used to design the feedback handling activities. A promise initially chosen for development turned out to be difficult to implement, experience that helped in selecting and developing the final promise. Research participants found the ISO 10001-based method useful and comprehensible. This paper presents a specific health care example of how to adapt a standard's guideline in establishing customer promises. The authors show how a promise can be used in alleviating an existing issue (i.e. communication between carers and patients). The learning can be beneficial in various health care settings. To the knowledge, this paper shows the first example of applying ISO 10001:2007 in a health care case. A few activities suggested by the standard are further detailed, and a new activity is introduced. The integrated use of ISO 10001:2007 and 10002:2004 is presented and how one can be "augmented" by the other is demonstrated.

  13. Novel hold-release functionality in a P300 brain-computer interface

    Science.gov (United States)

    Alcaide-Aguirre, R. E.; Huggins, J. E.

    2014-12-01

    Assistive technology control interface theory describes interface activation and interface deactivation as distinct properties of any control interface. Separating control of activation and deactivation allows precise timing of the duration of the activation. Objective. We propose a novel P300 brain-computer interface (BCI) functionality with separate control of the initial activation and the deactivation (hold-release) of a selection. Approach. Using two different layouts and off-line analysis, we tested the accuracy with which subjects could (1) hold their selection and (2) quickly change between selections. Main results. Mean accuracy across all subjects for the hold-release algorithm was 85% with one hold-release classification and 100% with two hold-release classifications. Using a layout designed to lower perceptual errors, accuracy increased to a mean of 90% and the time subjects could hold a selection was 40% longer than with the standard layout. Hold-release functionality provides improved response time (6-16 times faster) over the initial P300 BCI selection by allowing the BCI to make hold-release decisions from very few flashes instead of after multiple sequences of flashes. Significance. For the BCI user, hold-release functionality allows for faster, more continuous control with a P300 BCI, creating new options for BCI applications.

  14. Qualitative assessment of contrast-enhanced magnetic resonance angiography using breath-hold and non-breath-hold techniques in the portal venous system

    Science.gov (United States)

    Goo, Eun-Hoe; Kim, Sun-Ju; Dong, Kyung-Rae; Kim, Kwang-Choul; Chung, Woon-Kwan

    2016-09-01

    The purpose of this study is to evaluate the image quality in delineation of the portal venous systems with two different methods, breath-hold and non-breath-hold by using the 3D FLASH sequence. We used a 1.5 T system to obtain magnetic resonance(MR)images. Arterial and portal phase 3D FLASH images were obtained with breath-hold after a bolus injection of GD-DOTA. The detection of PVS on the MR angiograms was classified into three grades. First, the angiograms of the breath-hold method showed well the portal vein, the splenic vein and the superior mesenteric vein systems in 13 of 15 patients (86%) and the inferior mesenteric vein system in 6 of 15 patients (40%), Second, MR angiograms of the non-breath-hold method demonstrated the PVS and the SMV in 12 of 15 patients (80%) and the IMV in 5 of 15 patients (33%). Our study showed contrast-enhanced 3D FLASH MR angiography, together with the breath-hold technique, may provide reliable and accurate information on the portal venous system.

  15. Promise Zone Round 2 Applicant Geography and Goal Data

    Data.gov (United States)

    Department of Housing and Urban Development — This dataset includes Promise Zone initiative round II applicant project data from 111 urban, rural, and tribal communities who consented to share their application...

  16. Lactose crystallization: current issues and promising Engineering solutions

    OpenAIRE

    Rjabova, A.; Kirsanov, V.; Strizhko, M.; Bredikhin, A.; Semipyatnyi, V.; Chervetsov, V.; Galstyan, A.

    2013-01-01

    Current technological aspects of lactose crystallization are considered. A promising lactose crystallization method involving simulation seed crystals is reported. Advanced engineering solutions for continuous crystallization using spraying in vacuo and scraped-surface heat exchangers are presented.

  17. Protein Replacement Therapy Shows Promise in Treating Rare Skin Disorder

    Science.gov (United States)

    ... 1999 Spotlight on Research 2014 February 2014 (historical) Protein Replacement Therapy Shows Promise in Treating Rare Skin Disorder Replacing a protein that is crucial to ensuring that the skin’s ...

  18. Genital Herpes Vaccine Shows Promise in Animal Trials

    Science.gov (United States)

    ... 163137.html Genital Herpes Vaccine Shows Promise in Animal Trials Two-pronged approach tested on lab monkeys, guinea ... vaccines have not shown very robust protection in animal and human trials. Friedman and his colleagues decided that an effective ...

  19. Web-Based Help for Insomnia Shows Promise

    Science.gov (United States)

    ... page: https://medlineplus.gov/news/fullstory_162290.html Web-Based Help for Insomnia Shows Promise Interactive program ... Now, insomnia might be one of them. A web-based interactive program may help chronically sleepless individuals ...

  20. The Promise and Prejudice of Big Data in Intelligence Community

    OpenAIRE

    Jani, Karan

    2016-01-01

    Big data holds critical importance in the current generation of information technology, with applications ranging from financial, industrial, academic to defense sectors. With the exponential rise of open source data from social media and increasing government monitoring, big data is now also linked with national security, and subsequently to the intelligence community. In this study I review the scope of big data sciences in the functioning of intelligence community. The major part of my stu...

  1. [Promises and limits of genomics and its applications].

    Science.gov (United States)

    Gros, François

    2015-01-01

    This text traces the extraordinary advances made in genomics for 40 years: recombinant DNA, transgenesis or genetic sequencing. In recent years, the model "all genetics" was questioned and post-genomics emerged in the molecular landscape. The promises of medical advances are many and the ethical issues that accompany them are challenges. Advances in synthetic biology are a relevant illustration of these promises and challenges.

  2. 12 CFR 575.12 - Conversion or liquidation of mutual holding companies.

    Science.gov (United States)

    2010-01-01

    ...—(1) Generally. A mutual holding company may convert to the stock form in accordance with the rules and regulations set forth in part 563b of this chapter. (2) Exchange of savings association stock. Any stock issued pursuant to § 575.7 by a subsidiary savings association or subsidiary holding company of...

  3. Exploring the financial rationales of Dutch forest holdings and their relation with financial results

    NARCIS (Netherlands)

    Hoogstra-Klein, M.A.

    2016-01-01

    The financial situation of many forest holdings inthe Netherlands is a major concern. For example, the yearly overview of Dutch private forest holdings larger than 5 ha shows that over the las t 30 years, the average annual results were negative during most years. However, it should be taken into ac

  4. 20 CFR 703.103 - Stock companies holding Treasury certificates of authority.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Stock companies holding Treasury certificates... REGULATIONS Authorization of Insurance Carriers § 703.103 Stock companies holding Treasury certificates of... the Secretary of the Treasury as an acceptable surety on Federal bonds, unless requested to do...

  5. 39 CFR 447.52 - Holding of State or local office by Postal Service employees.

    Science.gov (United States)

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Holding of State or local office by Postal Service employees. 447.52 Section 447.52 Postal Service UNITED STATES POSTAL SERVICE PERSONNEL RULES OF CONDUCT FOR POSTAL EMPLOYEES Participation in Community Affairs § 447.52 Holding of State or local office by Postal...

  6. The Ins and Outs of Breath Holding: Simple Demonstrations of Complex Respiratory Physiology

    Science.gov (United States)

    Skow, Rachel J.; Day, Trevor A.; Fuller, Jonathan E.; Bruce, Christina D.; Steinback, Craig D.

    2015-01-01

    The physiology of breath holding is complex, and voluntary breath-hold duration is affected by many factors, including practice, psychology, respiratory chemoreflexes, and lung stretch. In this activity, we outline a number of simple laboratory activities or classroom demonstrations that illustrate the complexity of the integrative physiology…

  7. 77 FR 20635 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2012-04-05

    ... From the Federal Register Online via the Government Publishing Office FEDERAL RESERVE SYSTEM Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice... Officer) 90 Hennepin Avenue, Minneapolis, Minnesota 55480-0291: 1. Leackco Banking Holding Company,...

  8. Ape Behavior in Two Alternating Environments: Comparing Exhibit and Short-Term Holding Areas

    DEFF Research Database (Denmark)

    Ross, Stephen R.; Wagner, Katherine E.; Schapiro, Steven J.

    2010-01-01

    -specific reactions to the holding area, including increased aggression and self-directed behavior by chimpanzees and increased activity and prosocial behavior among gorilla subjects. Both species showed more feeding-foraging behavior while in the exhibit enclosure. Results suggest that holding areas may not meet all...

  9. 12 CFR 1500.3 - What are the holding periods permitted for merchant banking investments?

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false What are the holding periods permitted for merchant banking investments? 1500.3 Section 1500.3 Banks and Banking DEPARTMENT OF THE TREASURY GENERAL PROVISIONS MERCHANT BANKING INVESTMENTS § 1500.3 What are the holding periods permitted for merchant banking...

  10. 12 CFR 250.200 - Investment in bank premises by holding company banks.

    Science.gov (United States)

    2010-01-01

    ... company, is required to include indebtedness of a corporation, wholly owned by the holding company, that... “affiliate of each of the holding company's majority-owned banks as that term is defined in said section 2... is owned by such an affiliate, must include the affiliate's total indebtedness in determining...

  11. 75 FR 2544 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2010-01-15

    ... Commercial Bank, Lockport, New York, and thereby engage in operating a savings association, pursuant to... Central Financial, Inc., Annandale, Minnesota; to become a bank holding company by acquiring 100 percent... Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this...

  12. Heterogeneity among methicillin-resistant Staphylococcus aureus from Italian pig finishing holdings

    DEFF Research Database (Denmark)

    Battisti, A.; Franco, A.; Merialdi, G.;

    2010-01-01

    A survey for methicillin-resistant Staphylococcus aureus (MRSA) in finishing pig holdings was carried out in Italy in 2008. MRSA isolates were characterised by spa-. SCCmec- and antimicrobial susceptibility typing. A prevalence of 38% (45/118, 95% CI 29.4-46.9%) positive holdings was observed...

  13. Do social factors influence investment behavior and performance? Evidence from mutual fund holdings

    NARCIS (Netherlands)

    Borgers, Arian; Derwall, J.M.M.; Koedijk, Kees; ter Horst, Jenke

    2015-01-01

    We study the economic significance of social dimensions in investment decisions by analyzing the holdings of U.S. equity mutual funds over the period 2004-2012. Using these holdings, we measure funds' exposures to socially sensitive stocks in order to answer two questions. What explains cross-sectio

  14. Audiovisual biofeedback guided breath-hold improves lung tumor position reproducibility and volume consistency

    Directory of Open Access Journals (Sweden)

    Danny Lee, PhD

    2017-07-01

    Conclusions: This study demonstrated that audiovisual biofeedback can be used to improve the reproducibility and consistency of breath-hold lung tumor position and volume, respectively. These results may provide a pathway to achieve more accurate lung cancer radiation treatment in addition to improving various medical imaging and treatments by using breath-hold procedures.

  15. Do social factors influence investment behavior and performance? Evidence from mutual fund holdings

    NARCIS (Netherlands)

    Borgers, Arian; Derwall, J.M.M.; Koedijk, Kees; ter Horst, Jenke

    We study the economic significance of social dimensions in investment decisions by analyzing the holdings of U.S. equity mutual funds over the period 2004-2012. Using these holdings, we measure funds' exposures to socially sensitive stocks in order to answer two questions. What explains

  16. 75 FR 71440 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2010-11-23

    ... York, which will continue to operate an equipment finance company, pursuant to sections 225.28(b)(1... Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12...

  17. 75 FR 1384 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2010-01-11

    ... regulations to become a bank holding company and/or to acquire the assets or the ownership of, control of, or..., Missouri 64198-0001: 1. First National Management Group, LLC, Greenwood Village, Colorado; to become a bank... Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this...

  18. 77 FR 76160 - New Generation Biofuels Holdings, Inc.; Order of Suspension of Trading

    Science.gov (United States)

    2012-12-26

    ... From the Federal Register Online via the Government Publishing Office SECURITIES AND EXCHANGE COMMISSION New Generation Biofuels Holdings, Inc.; Order of Suspension of Trading December 21, 2012. It... concerning the securities of New Generation Biofuels Holdings, Inc. because it has not filed any periodic...

  19. 77 FR 51064 - Dana Holding Corporation, Power Technologies Group Division, Including On-Site Leased Workers...

    Science.gov (United States)

    2012-08-23

    ... Employment and Training Administration Dana Holding Corporation, Power Technologies Group Division, Including... Holding Corporation, Power Technologies Group Division, Milwaukee, Wisconsin (subject firm). The negative... competitive articles) in 2011 and 2012, loss of business with a firm that employed a worker group eligible...

  20. 78 FR 69605 - Standards for the Growing, Harvesting, Packing, and Holding of Produce for Human Consumption...

    Science.gov (United States)

    2013-11-20

    ... Growing, Harvesting, Packing, and Holding of Produce for Human Consumption; Extension of Comment Periods... Holding of Produce for Human Consumption'' and for its information collection provisions. DATES: The FDA... for Human Consumption.'' The original comment period of 120 days was extended several times and...

  1. 47 CFR 13.11 - Holding more than one commercial radio operator license.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Holding more than one commercial radio operator license. 13.11 Section 13.11 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL COMMERCIAL RADIO OPERATORS General § 13.11 Holding more than one commercial radio operator license. (a) An eligible...

  2. 77 FR 52033 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2012-08-28

    ... Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C... company, the review also includes whether the acquisition of the nonbanking company complies with...

  3. 76 FR 78658 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2011-12-19

    ... Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C... company, the review also includes whether the acquisition of the nonbanking company complies with...

  4. 78 FR 23934 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2013-04-23

    ... Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C... company, the review also includes whether the acquisition of the nonbanking company complies with...

  5. 78 FR 21949 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2013-04-12

    ... Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C... company, the review also includes whether the acquisition of the nonbanking company complies with...

  6. 77 FR 50106 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2012-08-20

    ... Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C... company, the review also includes whether the acquisition of the nonbanking company complies with...

  7. 77 FR 17479 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2012-03-26

    ... Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C... company, the review also includes whether the acquisition of the nonbanking company complies with...

  8. 77 FR 54578 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2012-09-05

    ... Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C... company, the review also includes whether the acquisition of the nonbanking company complies with...

  9. 76 FR 80945 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2011-12-27

    ... Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C... company, the review also includes whether the acquisition of the nonbanking company complies with...

  10. 78 FR 23935 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2013-04-23

    ... Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C... company, the review also includes whether the acquisition of the nonbanking company complies with...

  11. 77 FR 12057 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2012-02-28

    ... Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C... company, the review also includes whether the acquisition of the nonbanking company complies with...

  12. 77 FR 61607 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2012-10-10

    ... Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C... company, the review also includes whether the acquisition of the nonbanking company complies with...

  13. 78 FR 5179 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2013-01-24

    ... Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C... company, the review also includes whether the acquisition of the nonbanking company complies with...

  14. 78 FR 35930 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2013-06-14

    ... Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C... nonbanking company, the review also includes whether the acquisition of the nonbanking company complies...

  15. 77 FR 60435 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2012-10-03

    ... Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C... company, the review also includes whether the acquisition of the nonbanking company complies with...

  16. 78 FR 37541 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2013-06-21

    ... Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C... company, the review also includes whether the acquisition of the nonbanking company complies with...

  17. 78 FR 54647 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2013-09-05

    ... Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C... company, the review also includes whether the acquisition of the nonbanking company complies with...

  18. 78 FR 67363 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2013-11-12

    ... Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C... company, the review also includes whether the acquisition of the nonbanking company complies with...

  19. 78 FR 76146 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2013-12-16

    ... Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C... company, the review also includes whether the acquisition of the nonbanking company complies with...

  20. 77 FR 41188 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2012-07-12

    ... Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice... company, the review also includes whether the acquisition of the nonbanking company complies with the... holding company through the acquisition of 100 percent of the voting shares of CNBO Bancorp, Inc.,...

  1. 77 FR 76039 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2012-12-26

    ... Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice... company, the review also includes whether the acquisition of the nonbanking company complies with the... bank holding company upon the merger of Flushing Savings Bank, FSB, Flushing, New York, with and...

  2. 77 FR 22786 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2012-04-17

    ... Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C... company, the review also includes whether the acquisition of the nonbanking company complies with...

  3. 78 FR 28597 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2013-05-15

    ... Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C... company, the review also includes whether the acquisition of the nonbanking company complies with...

  4. 78 FR 68445 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2013-11-14

    ... Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C... company, the review also includes whether the acquisition of the nonbanking company complies with...

  5. 77 FR 59613 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2012-09-28

    ... Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C... company, the review also includes whether the acquisition of the nonbanking company complies with...

  6. 77 FR 59195 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2012-09-26

    ... Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C... company, the review also includes whether the acquisition of the nonbanking company complies with...

  7. 77 FR 15110 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2012-03-14

    ... Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C... company, the review also includes whether the acquisition of the nonbanking company complies with...

  8. 77 FR 23249 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2012-04-18

    ... Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C... company, the review also includes whether the acquisition of the nonbanking company complies with...

  9. 78 FR 18340 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2013-03-26

    ... Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C... company, the review also includes whether the acquisition of the nonbanking company complies with...

  10. 77 FR 23482 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2012-04-19

    ... Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C... company, the review also includes whether the acquisition of the nonbanking company complies with...

  11. 77 FR 65382 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2012-10-26

    ... Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C... company, the review also includes whether the acquisition of the nonbanking company complies with...

  12. 77 FR 57088 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2012-09-17

    ... Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C... company, the review also includes whether the acquisition of the nonbanking company complies with...

  13. 78 FR 19709 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2013-04-02

    ... Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C... company, the review also includes whether the acquisition of the nonbanking company complies with...

  14. 76 FR 76412 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2011-12-07

    ...; to become a bank holding company by acquiring 100 percent of the voting shares of First Advantage... the voting shares of First Federal Savings and Loan Bank, Olathe, Kansas. D. Federal Reserve Bank of... Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this...

  15. 12 CFR 225.102 - Bank holding company indirectly owning nonbanking company through subsidiaries.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Bank holding company indirectly owning nonbanking company through subsidiaries. 225.102 Section 225.102 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM BANK HOLDING COMPANIES AND CHANGE IN...

  16. 31 CFR 597.203 - Holding of funds in interest-bearing accounts; investment and reinvestment.

    Science.gov (United States)

    2010-07-01

    ... as otherwise directed by the Office of Foreign Assets Control, any U.S. financial institution holding... under the Securities Exchange Act of 1934, provided the funds are invested in a money market fund or in... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Holding of funds in interest-bearing...

  17. 75 FR 22168 - Global Medical Products Holdings, Inc., Order of Suspension of Trading

    Science.gov (United States)

    2010-04-27

    ... From the Federal Register Online via the Government Publishing Office SECURITIES AND EXCHANGE COMMISSION Global Medical Products Holdings, Inc., Order of Suspension of Trading April 23, 2010. It appears... concerning the securities of Global Medical Products Holdings, Inc. because it has not filed any periodic...

  18. 12 CFR 16.9 - Securities offered and sold in holding company dissolution.

    Science.gov (United States)

    2010-01-01

    ... dissolution. 16.9 Section 16.9 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY SECURITIES OFFERING DISCLOSURE RULES § 16.9 Securities offered and sold in holding company dissolution. Offers and sales of bank issued securities in connection with the dissolution of the holding company of...

  19. 77 FR 30001 - PBF Holding Company LLC, Toledo Refining Company LLC v. Enbridge Energy, Limited Partnership...

    Science.gov (United States)

    2012-05-21

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission PBF Holding Company LLC, Toledo Refining Company LLC v. Enbridge Energy... to Oil Pipeline Proceedings, 18 CFR 343.1(a), PBF Holding Company LLC and Toledo Refining Company...

  20. 77 FR 10598 - BIOTECH Holdings Ltd., California Oil & Gas Corp., Central Minera Corp., Chemokine Therapeutics...

    Science.gov (United States)

    2012-02-22

    ... From the Federal Register Online via the Government Publishing Office SECURITIES AND EXCHANGE COMMISSION BIOTECH Holdings Ltd., California Oil & Gas Corp., Central Minera Corp., Chemokine Therapeutics... concerning the securities of BIOTECH Holdings Ltd. because it has not filed any annual reports since...

  1. Copenhagen's climate finance promise: six key questions

    Energy Technology Data Exchange (ETDEWEB)

    Roberts, J. Timmons [Brown University (United States); Stadelmann, Martin [University of Zurich (Switzerland); Huq, Saleemul

    2010-02-15

    One clear promise emerged from the confusion of the 2009 climate talks in Copenhagen. This was to provide short- and long-term 'climate finance' to help developing countries – especially the most vulnerable – adapt to climate impacts. The promise seemed simple enough: wealthier nations would pledge US$10 billion a year from 2010-2012, ramping up to US$100 billion a year starting in 2020. This was also touted as a way to help developing countries avoid high-carbon pathways of development by adopting lower-emitting power sources such as solar or natural gas. But a closer look at the Copenhagen promise unearths at least six big questions – any one of which could seriously challenge the trust these funds were designed to build.

  2. Local and Global Trust Based on the Concept of Promises

    CERN Document Server

    Bergstra, Jan

    2009-01-01

    We use the notion of a promise to define local trust between agents possessing autonomous decision-making. An agent is trustworthy if it is expected that it will keep a promise. This definition satisfies most commonplace meanings of trust. Reputation is then an estimation of this expectation value that is passed on from agent to agent. Our definition distinguishes types of trust, for different behaviours, and decouples the concept of agent reliability from the behaviour on which the judgement is based. We show, however, that trust is fundamentally heuristic, as it provides insufficient information for agents to make a rational judgement. A global trustworthiness, or community trust can be defined by a proportional, self-consistent voting process, as a weighted eigenvector-centrality function of the promise theoretical graph.

  3. Congestion Service Facilities Location Problem with Promise of Response Time

    Directory of Open Access Journals (Sweden)

    Dandan Hu

    2013-01-01

    Full Text Available In many services, promise of specific response time is advertised as a commitment by the service providers for the customer satisfaction. Congestion on service facilities could delay the delivery of the services and hurts the overall satisfaction. In this paper, congestion service facilities location problem with promise of response time is studied, and a mixed integer nonlinear programming model is presented with budget constrained. The facilities are modeled as M/M/c queues. The decision variables of the model are the locations of the service facilities and the number of servers at each facility. The objective function is to maximize the demands served within specific response time promised by the service provider. To solve this problem, we propose an algorithm that combines greedy and genetic algorithms. In order to verify the proposed algorithm, a lot of computational experiments are tested. And the results demonstrate that response time has a significant impact on location decision.

  4. Formaldehyde: catalytic oxidation as a promising soft way of elimination.

    Science.gov (United States)

    Quiroz Torres, Jhon; Royer, Sébastien; Bellat, Jean-Pierre; Giraudon, Jean-Marc; Lamonier, Jean-François

    2013-04-01

    Compared to other molecules such as benzene, toluene, xylene, and chlorinated compounds, the catalytic oxidation of formaldehyde has been studied rarely. However, standards for the emission level of this pollutant will become more restrictive because of its extreme toxicity even at very low concentrations in air. As a consequence, the development of a highly efficient process for its selective elimination is needed. Complete catalytic oxidation of formaldehyde into CO2 and H2 O using noble-metal-based catalysts is a promising method to convert this pollutant at room temperature, making this process energetically attractive from an industrial point of view. However, the development of a less expensive active phase is required for a large-scale industrial development. Nanomaterials based on oxides of manganese are described as the most promising catalysts. The objective of this Minireview is to present promising recent studies on the removal of formaldehyde through heterogeneous catalysis to stimulate future research in this topic.

  5. Promise-based management: the essence of execution.

    Science.gov (United States)

    Sull, Donald N; Spinosa, Charles

    2007-04-01

    Critical initiatives stall for a variety of reasons--employee disengagement, a lack of coordination between functions, complex organizational structures that obscure accountability, and so on. To overcome such obstacles, managers must fundamentally rethink how work gets done. Most of the challenges stem from broken or poorly crafted commitments. That's because every company is, at its heart, a dynamic network of promises made between employees and colleagues, customers, outsourcing partners, or other stakeholders. Executives can overcome many problems in the short-term and foster productive, reliable workforces for the long-term by practicing what the authors call "promise-based management," which involves cultivating and coordinating commitments in a systematic way. Good promises share five qualities: They are public, active, voluntary, explicit, and mission based. To develop and execute an effective promise, the "provider" and the "customer" in the deal should go through three phases of conversation. The first, achieving a meeting of minds, entails exploring the fundamental questions of coordinated effort: What do you mean? Do you understand what I mean? What should I do? What will you do? Who else should we talk to? In the next phase, making it happen, the provider executes on the promise. In the final phase, closing the loop, the customer publicly declares that the provider has either delivered the goods or failed to do so. Leaders must weave and manage their webs of promises with great care-encouraging iterative conversation and making sure commitments are fulfilled reliably. If they do, they can enhance coordination and cooperation among colleagues, build the organizational agility required to seize new business opportunities, and tap employees' entrepreneurial energies.

  6. CRISPR-Cas9 systems: versatile cancer modelling platforms and promising therapeutic strategies.

    Science.gov (United States)

    Wen, Wan-Shun; Yuan, Zhi-Min; Ma, Shi-Jie; Xu, Jiang; Yuan, Dong-Tang

    2016-03-15

    The RNA-guided nuclease CRISPR-Cas9 (clustered regularly interspaced short palindromic repeats-CRISPR associated nuclease 9) and its variants such as nickase Cas9, dead Cas9, guide RNA scaffolds and RNA-targeting Cas9 are convenient and versatile platforms for site-specific genome editing and epigenome modulation. They are easy-to-use, simple-to-design and capable of targeting multiple loci simultaneously. Given that cancer develops from cumulative genetic and epigenetic alterations, CRISPR-Cas9 and its variants (hereafter referred to as CRISPR-Cas9 systems) hold extensive application potentials in cancer modeling and therapy. To date, they have already been applied to model oncogenic mutations in cell lines (e.g., Choi and Meyerson, Nat Commun 2014;5:3728) and in adult animals (e.g., Xue et al., Nature 2014;514:380-4), as well as to combat cancer by disabling oncogenic viruses (e.g., Hu et al., Biomed Res Int 2014;2014:612823) or by manipulating cancer genome (e.g., Liu et al., Nat Commun 2014;5:5393). Given the importance of epigenome and transcriptome in tumourigenesis, manipulation of cancer epigenome and transcriptome for cancer modeling and therapy is a promising area in the future. Whereas (epi)genetic modifications of cancer microenvironment with CRISPR-Cas9 systems for therapeutic purposes represent another promising area in cancer research. Herein, we introduce the functions and mechanisms of CRISPR-Cas9 systems in genome editing and epigenome modulation, retrospect their applications in cancer modelling and therapy, discuss limitations and possible solutions and propose future directions, in hope of providing concise and enlightening information for readers interested in this area.

  7. Analysis of cash holding for measuring the efficiency of cash management: A study on IT sector

    Directory of Open Access Journals (Sweden)

    Somnath Das

    2015-01-01

    Full Text Available For measuring the efficiency of management of cash, cash holding is one of the most important financial decisions that the manager of the concerned organization, has to make in the organization. Basically, it is observed that the organization hold cash for future purposes is very negligible. If the organization invested cash in profitable securities then there is some flexibility but when it relates to the capital market holding cash is not advantageous. Generally two contradictory theories such as Trade-off theory and the Pecking order theory are considered for measuring the efficiency of cash management. In this study we generally observed measured the efficiency of Cash Management influenced by Cash Holding. We also measured whether cash holding of the organization is affected with the degree of financial leverage, size of the organization, investment and profitability. This study helps us to understand the influence of DFL, Investment and Size of the organization on Cash holding. Proper holding of cash in cash management can prevent the bankruptcy of any organization and also increases the efficiency of Cash or Liquidity management.

  8. EVALUATION OF THE IMPACT OF INNOVATIVE PROJECTS ON THE COMPETITIVENESS OF AGRICULTURAL HOLDINGS IN SLOVAK REPUBLIC

    Directory of Open Access Journals (Sweden)

    Ľubica RUMANOVSKÁ

    2013-01-01

    Full Text Available The scientific paper evaluates the impact of innovative projects on the competitiveness of agricultural holdings in SR. Evaluation of the impact of innovative projects on competitiveness of agricultural holdings was realized on the selected holdings in Nitra and Trnava region. For the evaluation was used RCR coefficient. With the use of RCR coefficient could be confirmed the scientific hypothesis - The innovative projects realized through Program for rural development SR 2007-2013 have positive impact on competitiveness of agricultural holdings. The possibilities for EU financial support for innovative projects in SR represent important source for introduction of new innovative technologies into production process and in future they can significantly contribute to the growth of competitiveness of agricultural subjects. Therefore, to increase competitiveness of agricultural holdings it is important to focus on modernization of machinery and buildings, use of natural sources for energy production, but also to increase the education and the flow of information between rural inhabitants, mainly farmers. In competitive area of EU agricultural sector it is necessary that agricultural holdings will innovate, not only to create independent flow of innovative products and knowledge, but also to increase its value on internal market. Agricultural holdings –receivers of financial support – have expressed the opinion that financial support realized through PRD SR 2007-2013 had definitely allowed them to implement new processes and products.

  9. Big data analytics in healthcare: promise and potential.

    Science.gov (United States)

    Raghupathi, Wullianallur; Raghupathi, Viju

    2014-01-01

    To describe the promise and potential of big data analytics in healthcare. The paper describes the nascent field of big data analytics in healthcare, discusses the benefits, outlines an architectural framework and methodology, describes examples reported in the literature, briefly discusses the challenges, and offers conclusions. The paper provides a broad overview of big data analytics for healthcare researchers and practitioners. Big data analytics in healthcare is evolving into a promising field for providing insight from very large data sets and improving outcomes while reducing costs. Its potential is great; however there remain challenges to overcome.

  10. Promising design options for the encapsulated nuclear heat source reactor

    Energy Technology Data Exchange (ETDEWEB)

    Conway, L.; Carelli, M.D.; Dzodzo, M. [Westinghouse Science and Technology, Pittsburgh, PA (United States); Hossain, Q.; Brown, N.W. [Lawrence Livermore National Lab., CA (United States); Wade, D.C.; Sienick, J.J. [Argonne National Lab., IL (United States); Greenspan, E.; Kastenberg, W.E.; Saphier, D. [University of California Dept of Nuclear Engineering, Berkeley, CA (United States)

    2001-07-01

    Promising design options for the Encapsulated Nuclear Heat Source (ENHS) liquid-metal cooled fast reactor were identified during the first year of the DOE NERI program sponsored feasibility study. Many opportunities for incorporation of innovations in design and fabrication were identified. Three of the innovations are hereby described: a novel IHX (intermediate heat exchanger) made of a relatively small number of rectangular channels, an ENHS module design featuring 100% natural circulation, and a novel conceptual design of core support and fuelling. As a result of the first year study the ENHS concept appears more practical and more promising than perceived at the outset of this study. (authors)

  11. Accuracy Evaluation of a 3-Dimensional Surface Imaging System for Guidance in Deep-Inspiration Breath-Hold Radiation Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Alderliesten, Tanja; Sonke, Jan-Jakob; Betgen, Anja; Honnef, Joeri; Vliet-Vroegindeweij, Corine van [Department of Radiation Oncology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam (Netherlands); Remeijer, Peter, E-mail: p.remeijer@nki.nl [Department of Radiation Oncology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam (Netherlands)

    2013-02-01

    Purpose: To investigate the applicability of 3-dimensional (3D) surface imaging for image guidance in deep-inspiration breath-hold radiation therapy (DIBH-RT) for patients with left-sided breast cancer. For this purpose, setup data based on captured 3D surfaces was compared with setup data based on cone beam computed tomography (CBCT). Methods and Materials: Twenty patients treated with DIBH-RT after breast-conserving surgery (BCS) were included. Before the start of treatment, each patient underwent a breath-hold CT scan for planning purposes. During treatment, dose delivery was preceded by setup verification using CBCT of the left breast. 3D surfaces were captured by a surface imaging system concurrently with the CBCT scan. Retrospectively, surface registrations were performed for CBCT to CT and for a captured 3D surface to CT. The resulting setup errors were compared with linear regression analysis. For the differences between setup errors, group mean, systematic error, random error, and 95% limits of agreement were calculated. Furthermore, receiver operating characteristic (ROC) analysis was performed. Results: Good correlation between setup errors was found: R{sup 2}=0.70, 0.90, 0.82 in left-right, craniocaudal, and anterior-posterior directions, respectively. Systematic errors were {<=}0.17 cm in all directions. Random errors were {<=}0.15 cm. The limits of agreement were -0.34-0.48, -0.42-0.39, and -0.52-0.23 cm in left-right, craniocaudal, and anterior-posterior directions, respectively. ROC analysis showed that a threshold between 0.4 and 0.8 cm corresponds to promising true positive rates (0.78-0.95) and false positive rates (0.12-0.28). Conclusions: The results support the application of 3D surface imaging for image guidance in DIBH-RT after BCS.

  12. EXCESS CASH HOLDINGS DAN KEPEMILIKAN INSTITUSIONAL PADA PERUSAHAAN MANUFAKTUR YANG TERDAFTAR DI BEI

    Directory of Open Access Journals (Sweden)

    Yessica Tria Christina

    2014-02-01

    Full Text Available This research provides an empirical evidence about the effect of institutional ownerships as a proxy of information transparancy on excess cash holdings. Manufacture companies listed on BEI from years 2002 to 2011 are employed. The results show that the higher the proportion of institutional ownership, the lower the excess cash holdings. Informational transparancy, as one of the requirements of good corporate governance, can in fact lower the chance of aggrevating the manager’s behavior to practice excess cash holdings that can lower the company’s efficiency.

  13. The Promise of Mixed-Methods for Advancing Latino Health Research

    Science.gov (United States)

    Apesoa-Varano, Ester Carolina; Hinton, Ladson

    2015-01-01

    Mixed-methods research in the social sciences has been conducted for quite some time. More recently, mixed-methods have become popular in health research, with the National Institutes of Health leading the impetus to fund studies that implement such an approach. The public health issues facing us today are great and they range from policy and other macro-level issues, to systems level problems to individuals' health behaviors. For Latinos, who are projected to become the largest minority group bearing a great deal of the burden of social inequality in the U.S., it is important to understand the deeply-rooted nature of these health disparities in order to close the gap in health outcomes. Mixed-methodology thus holds promise for advancing research on Latino heath by tackling health disparities from a variety of standpoints and approaches. The aim of this manuscript is to provide two examples of mixed methods research, each of which addresses a health topic of considerable importance to older Latinos and their families. These two examples will illustrate a) the complementary use of qualitative and quantitative methods to advance health of older Latinos in an area that is important from a public health perspective, and b) the “translation” of findings from observational studies (informed by social science and medicine) to the development and testing of interventions. PMID:23996325

  14. The promise of mixed-methods for advancing latino health research.

    Science.gov (United States)

    Apesoa-Varano, Ester Carolina; Hinton, Ladson

    2013-09-01

    Mixed-methods research in the social sciences has been conducted for quite some time. More recently, mixed-methods have become popular in health research, with the National Institutes of Health leading the impetus to fund studies that implement such an approach. The public health issues facing us today are great and they range from policy and other macro-level issues, to systems level problems to individuals' health behaviors. For Latinos, who are projected to become the largest minority group bearing a great deal of the burden of social inequality in the U.S., it is important to understand the deeply-rooted nature of these health disparities in order to close the gap in health outcomes. Mixed-methodology thus holds promise for advancing research on Latino heath by tackling health disparities from a variety of standpoints and approaches. The aim of this manuscript is to provide two examples of mixed methods research, each of which addresses a health topic of considerable importance to older Latinos and their families. These two examples will illustrate a) the complementary use of qualitative and quantitative methods to advance health of older Latinos in an area that is important from a public health perspective, and b) the "translation" of findings from observational studies (informed by social science and medicine) to the development and testing of interventions.

  15. The promises of stem cells: stem cell therapy for movement disorders.

    Science.gov (United States)

    Mochizuki, Hideki; Choong, Chi-Jing; Yasuda, Toru

    2014-01-01

    Despite the multitude of intensive research, the exact pathophysiological mechanisms underlying movement disorders including Parkinson's disease, multiple system atrophy and Huntington's disease remain more or less elusive. Treatments to halt these disease progressions are currently unavailable. With the recent induced pluripotent stem cells breakthrough and accomplishment, stem cell research, as the vast majority of scientists agree, holds great promise for relieving and treating debilitating movement disorders. As stem cells are the precursors of all cells in the human body, an understanding of the molecular mechanisms that govern how they develop and work would provide us many fundamental insights into human biology of health and disease. Moreover, stem-cell-derived neurons may be a renewable source of replacement cells for damaged neurons in movement disorders. While stem cells show potential for regenerative medicine, their use as tools for research and drug testing is thought to have more immediate impact. The use of stem-cell-based drug screening technology could be a big boost in drug discovery for these movement disorders. Particular attention should also be given to the involvement of neural stem cells in adult neurogenesis so as to encourage its development as a therapeutic option. Copyright © 2013 Elsevier Ltd. All rights reserved.

  16. Promising Practices in Drug Treatment: Findings from Southeast Asia

    Science.gov (United States)

    Libretto, Salvatore; Nemes, Susanna; Namur, Jenny; Garrett, Gerald; Hess, Lauren; Kaplan, Linda

    2005-01-01

    In a study to evaluate the drug treatment and aftercare efforts sponsored by the State Department's International Narcotics and Law Enforcement Affairs Bureau, residential Therapeutic Community (TC) treatment programs in three countries in Southeast Asia--Malaysia, Singapore, and Thailand--were examined to identify promising practices and to…

  17. Diversity's Promise for Higher Education: Making It Work

    Science.gov (United States)

    Smith, Daryl G.

    2009-01-01

    Daryl G. Smith's career has been devoted to studying and fostering diversity in higher education. She has witnessed and encouraged the evolution of diversity from an issue addressed sporadically on college campuses to an imperative if institutions want to succeed. In "Diversity's Promise for Higher Education", she analyzes how diversity is…

  18. Dyslipidaemia in 2013: New statin guidelines and promising novel therapeutics.

    Science.gov (United States)

    Mikhailidis, Dimitri P; Athyros, Vasilios G

    2014-02-01

    The new ACC/AHA guidelines on treatment of blood cholesterol focus on intensity of statin therapy rather than target levels of lipids. Early studies show substantial reductions in LDL-cholesterol level with antibodies against PCSK9. MicroRNA silencing and gene-repair techniques to treat dyslipidaemia are promising strategies under development.

  19. Understanding the promises and premises of online health platforms

    NARCIS (Netherlands)

    van Dijck, J.; Poell, T.

    2016-01-01

    This article investigates the claims and complexities involved in the platform-based economics of health and fitness apps. We examine a double-edged logic inscribed in these platforms, promising to offer personal solutions to medical problems while also contributing to the public good. On the one ha

  20. Competency Education Offers Promise and Peril for Students

    Science.gov (United States)

    Ritterband, Vicki; Heller, Rafael

    2015-01-01

    Lindsay Unified School District (California) exemplifies the promise of competency education (or performance-based education, as it is called locally). Since beginning its transition to the model in 2009, discipline problems have sharply dropped, the school climate has dramatically improved (as measured by the California Healthy Kids Survey), and…

  1. Parent Trigger Laws and the Promise of Parental Voice

    Science.gov (United States)

    Smith, William C.; Rowland, Julie

    2014-01-01

    Parent trigger laws have gained momentum nationally under the premise that they will increase local authority by amplifying parental voice in the decision to turn around "failing" schools. Using Hirschman's exit, voice, and loyalty framework we create two conceptual models of voice and evaluate the promise of voice in California, home of…

  2. Journey to Freedom: Reflecting on Our Responsibilities, Renewing Our Promises

    Science.gov (United States)

    Bull, Cheryl Crazy

    2012-01-01

    Over the past four decades, tribal colleges and universities (TCUs) have emerged as a cutting-edge approach to post-secondary education in the United States and across the world. They have emerged as exceptional institutions--and their leaders still have promises to keep and new goals to achieve. As people look to the future of the tribal…

  3. Reducing Aggressive Male Behavior in Elementary School: Promising Practices

    Science.gov (United States)

    Holmes, Barbara; Gibson, Jamel; Morrison-Danner, Dietrich

    2014-01-01

    Student aggression and violent behavior, especially among males, is pervasive and problematic in the classroom. When incorporated in the lesson design, promising practices (music, movement, and visual stimulation) are evidence-based strategies that may reduce male aggression in the classroom.

  4. Parent Trigger Laws and the Promise of Parental Voice

    Science.gov (United States)

    Smith, William C.; Rowland, Julie

    2014-01-01

    Parent trigger laws have gained momentum nationally under the premise that they will increase local authority by amplifying parental voice in the decision to turn around "failing" schools. Using Hirschman's exit, voice, and loyalty framework we create two conceptual models of voice and evaluate the promise of voice in California,…

  5. Understanding the promises and premises of online health platforms

    NARCIS (Netherlands)

    van Dijck, J.; Poell, T.

    2016-01-01

    This article investigates the claims and complexities involved in the platform-based economics of health and fitness apps. We examine a double-edged logic inscribed in these platforms, promising to offer personal solutions to medical problems while also contributing to the public good. On the one

  6. Promise and Progress of Millihertz Gravitational-Wave Astronomy

    Science.gov (United States)

    Baker, John G.

    2017-01-01

    Extending the new field of gravitational wave (GW) astronomy into the millihertz band with a space-based GW observatory is a high-priority objective of international astronomy community. This paper summarizes the astrophysical promise and the technological groundwork for such an observatory, concretely focusing on the prospects for the proposed Laser Interferometer Space Antenna (LISA) mission concept.

  7. Exact quantum algorithms for promise problems in automata theory

    CERN Document Server

    Yakaryilmaz, Abuzer

    2011-01-01

    In this note, we show that quantum finite automata can be polynomially more succinct than their classical counterparts for promise problems in case of exact computation. Additionally, in terms of language recognition, the same result is shown to be valid up to a constant factor depending on how bigger the size of the alphabet is.

  8. The Math Promise: Celebrating at Home and School

    Science.gov (United States)

    Legnard, Danielle; Austin, Susan

    2014-01-01

    The Math Promise is a contract that family members make with one another. They commit to spending mathematical time together; getting to know each other's mathematical thinking and understanding; and finding time to play math games, solve problems, and notice mathematics in their daily lives. Whether parents and children are cooking in the…

  9. Augmented Reality Based Doppler Lidar Data Visualization: Promises and Challenges

    Directory of Open Access Journals (Sweden)

    Cherukuru N. W.

    2016-01-01

    As a proof of concept, we used the lidar data from a recent field campaign and developed a smartphone application to view the lidar scan in augmented reality. In this paper, we give a brief methodology of this feasibility study, present the challenges and promises of using AR technology in conjunction with Doppler wind lidars.

  10. Promising Programs for Sex-Fair Vocational Education.

    Science.gov (United States)

    Butler, Matilda; And Others

    This collection of program descriptions consists of case studies of 47 programs that contain promising approaches to sex-fair vocational education. The case studies (which represent programs in 39 states and the District of Columbia) describe programs that address the educational and job-skill training needs of such groups as displaced homemakers,…

  11. Severe alcoholic hepatitis: Glucocorticoid saves lives and transplantation is promising

    Institute of Scientific and Technical Information of China (English)

    Alain Braillon

    2011-01-01

    Glucocorticosteroids have been used as the only treatment for a long time which significantly reduced the mortality of the patients with severe alcoholic hepatitis. The efficacy of transplantation has been recently addressed in a pilot study. The result seems promising but needs larger multicenter trials.

  12. Organizational suggestion system in the era of holding by developing an innovative model : the case of bonyade ta avon holding in Iran(an applied model

    Directory of Open Access Journals (Sweden)

    Meysam Ghasemi

    2010-01-01

    Full Text Available One of the popular ways of taking advantage of personnel creativity is through suggestionsystems. Our main question is how to implement suggestion system in holding with conglomeratestructure. The paper presents an innovative model that were named ITFSK Model with accordanceof Bonayade Taavone (a holding that has many companies and institutions with conglomeratestructure. ITFSK is a model that explains how participation management and suggestion system isimplemented effectively in huge Enterprises (holding and this approach brings continuousimprovement (kaizen and it impacts the productivity of these enterprises.The paper is based on field research and the research in Bonyade Tavan that has 22 companies and2 institutions that activity fields of the subholdings is very varied.Our model consists of five main parts such as ideas bank, think-tank, feedback, sharing ofknowledge and kaizen that was named ITFSK.Implementation of “Suggestion system” rules has immediate and significant effects on theproductivity of activities in the jobs, thus influencing the performance of processes in the analyzedorganization. Suggestion system can result in kaizen and innovation in environment oforganization.The model was used to implement and evaluate a suggestion system of holding with conglomeratedstructure. The application of the model to evaluate the suggestion system provided some goodinsights and highlighted some areas of improvement.

  13. The Promised Savior in Pre-Islamic Great Religions

    Directory of Open Access Journals (Sweden)

    Mahin Arab

    2014-09-01

    Full Text Available Since the ancient times the belief in the rise of the Reformer has been a fundamental principle. Many of the holy prophets have announced the advent of new prophet. Moreover in the announcements and indications of predecessors there are always allusions to "the Last Promised" and "the Savior of Last Days" under such titles as "Kalki", "Fifth Buddha", "Soshyans", "Messiah", "The Son of Man" and so on and so forth. Of course there are different types of belief in the last reformer in religions. In one place the Savior is merely a social reformer while in another place he is only after the spiritual salvation of people and even sometimes he undertakes both tasks. On the other hand, the Last Promised is once nationalist and once seeks to save the whole world.    This essay seeks to assay the views of pre-Islamic great religions including Zoroastrianism, Judaism, Christianity, Hinduism and Buddhism as to the Promised Savior. This essay is an analytico-descriptive research which has based itself on the first hand works comprising the sacred scriptures of religions and proceeds through the typological analyses of idea of the Promised in religions.    Zoroastrianism: the idea of the Promised has been tied to the notion of Soshyant. Generally speaking, this notion alludes to a group of people who periodically emerge at the end of every millennium of the last three millennia of world's age so as to uproot evil and renew the world, the last one of these reformers is Soshyans. According to the aforementioned typology, Zoroastrian idea of Last Savior is among the Promised who saves the whole world. Moreover Zoroastrian Promised cannot be declared only a social savior as he is not wholly detached from people's spirituality too. From another point of view, Zoroastrian idea of the Promised represents a universal and not nationalist savior who is relatively a human and not divine entity who emerges in the last millennium of world's age.    Judaism: in the

  14. The Promised Savior in Pre-Islamic Great Religions

    Directory of Open Access Journals (Sweden)

    Mahin Arab

    2014-08-01

    Full Text Available Since the ancient times the belief in the rise of the Reformer has been a fundamental principle. Many of the holy prophets have announced the advent of new prophet. Moreover in the announcements and indications of predecessors there are always allusions to "the Last Promised" and "the Savior of Last Days" under such titles as "Kalki", "Fifth Buddha", "Soshyans", "Messiah", "The Son of Man" and so on and so forth. Of course there are different types of belief in the last reformer in religions. In one place the Savior is merely a social reformer while in another place he is only after the spiritual salvation of people and even sometimes he undertakes both tasks. On the other hand, the Last Promised is once nationalist and once seeks to save the whole world.    This essay seeks to assay the views of pre-Islamic great religions including Zoroastrianism, Judaism, Christianity, Hinduism and Buddhism as to the Promised Savior. This essay is an analytico-descriptive research which has based itself on the first hand works comprising the sacred scriptures of religions and proceeds through the typological analyses of idea of the Promised in religions.    Zoroastrianism: the idea of the Promised has been tied to the notion of Soshyant. Generally speaking, this notion alludes to a group of people who periodically emerge at the end of every millennium of the last three millennia of world's age so as to uproot evil and renew the world, the last one of these reformers is Soshyans. According to the aforementioned typology, Zoroastrian idea of Last Savior is among the Promised who saves the whole world. Moreover Zoroastrian Promised cannot be declared only a social savior as he is not wholly detached from people's spirituality too. From another point of view, Zoroastrian idea of the Promised represents a universal and not nationalist savior who is relatively a human and not divine entity who emerges in the last millennium of world's age.    Judaism: in the

  15. 77 FR 27061 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2012-05-08

    ... South LaSalle Street, Chicago, Illinois 60690-1414: 1. Johnston Growth Corporation, Johnston, Iowa; to become a bank holding company following the conversion of its subsidiary, Charter Bank, Johnston,...

  16. 21 CFR 312.42 - Clinical holds and requests for modification.

    Science.gov (United States)

    2010-04-01

    ...., affecting reproductive organs) or developmental toxicity (i.e., affecting potential offspring). The phrase... death is high unless the course of the disease is interrupted.” The clinical hold would not apply...

  17. Factors Affecting Corporate Cash Holding of Non-Financial Firms in Pakistan

    Directory of Open Access Journals (Sweden)

    Atif Kafayat

    2014-06-01

    Full Text Available The previous researches explore the question of why firms hold cash. But there are few researches done in developing countries like Pakistan. The need for cash is characterized by its policies of firms regarding capital structure, working capital requirements, cash flow management, dividend payments, and asset management. In this paper, the impact of these factors is normally analyzed under the framework of Tradeoff theory, Pecking Order Theory and Free Cash Flow Theory. This paper focuses on determining the level of corporate cash holdings of non-financial Pakistani firms, and cash holding requirement among different industries. The data is set for period of 2008- 2012 by using the data of 40companies and 6 industries. The findings of the study support the theories. Which show that firm size, net working capital, leverage, Capital Expenditure and Dividend significantly affect the cash holdings of non-financial firms in Pakistan.

  18. Determinants of corporate cash holdings: Evidence from Portuguese publicly traded firms

    Directory of Open Access Journals (Sweden)

    Fernandes, Filipa

    2017-05-01

    Full Text Available This paper investigates the determinants of cash holdings of publicly traded Portuguese firms. We find that such firms hold less cash than similar companies operating in countries where both shareholders and creditors’ rights are more tightly protected by the law. In addition, our regression results suggest that leverage, other liquid assets, and firm growth are negatively correlated with our sample firms’ cash holdings whereas long-term debt and financial distress are positively correlated. Our findings cannot be reconciled with just one of the existent theories (trade-off, pecking order and free cashflow theory, and emphasize the importance of a country’s legal, institutional, and economic environment for explaining firms’ cash holdings decisions.

  19. Extension, cooperatives to hold 34th annual Forestry and Wildlife Field Tours

    OpenAIRE

    2010-01-01

    Virginia Cooperative Extension and the Virginia Forest Landowner Education Program in Virginia Tech's College of Natural Resources and Environment will hold their 34th Annual Fall Forestry and Wildlife Field Tour Programs starting Oct. 15.

  20. 46 CFR 154.902 - Atmospheric control within hold and interbarrier spaces.

    Science.gov (United States)

    2010-10-01

    ... containment systems with full secondary barriers must have an inert gas system or onboard storage of inert gas... must: (1) Have an inert gas system or onboard inert gas storage that can inert the largest hold...

  1. 78 FR 59938 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2013-09-30

    ... the power to vote shares of a bank or bank holding company and all of the banks and nonbanking...) 230 South LaSalle Street, Chicago, Illinois 60690-1414: 1. MB Financial, Inc., Chicago, Illinois;...

  2. Report: EPA Managers Did Not Hold Supervisors and Project Officers Accountable for Grants Management

    Science.gov (United States)

    Report #2005-P-00027, September 27, 2005. Managers did not sufficiently hold supervisors and project officers accountable for grants management because there is no process to measure most grants management activity.

  3. Extension, cooperatives to hold 33rd annual Forestry and Wildlife Field Tours

    OpenAIRE

    2009-01-01

    Virginia Cooperative Extension and the Virginia Forest Landowner Education Program, in collaboration with Virginia's natural resource agencies, companies, and associations, will hold their 33rdth Annual Fall Forestry and Wildlife Field Tours starting Sept. 24.

  4. A metal aerosol holding chamber devised for young children with asthma

    DEFF Research Database (Denmark)

    Bisgaard, H

    1995-01-01

    The low tidal volume and flow in preschool children may reduce the efficiency of aerosol delivery from a pressurized metered-dose inhaler (pMDI) through a traditional holding chamber. A prototype small-volume steel holding chamber with two one-way valves was devised to prolong aerosol availability...... children less than 8 yrs of age. In vitro, the half life of aerosol disappearance in the steel prototype and the plastic Nebuhaler was > 30 s and 9 s, respectively. In vivo, the prototype delivered an age-independent mean dose of 38% of the nominal dose, and the Nebuhaler delivered an age-dependent mean...... be achieved by pMDI aerosol inhaled through a small-volume metal holding chamber with separate inlet and outlet valves and minimized dead space. This holding chamber would improve the possibilities of aerosol therapy for young children....

  5. 75 FR 11888 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2010-03-12

    .... PBS Bancshares, Inc., Seneca, Missouri; to become a bank holding company by acquiring 87.31 percent of the voting shares of People's Bank of Seneca, Seneca, Missouri. B. Federal Reserve Bank of...

  6. 5 CFR 1690.15 - Freezing an account-administrative holds.

    Science.gov (United States)

    2010-01-01

    ... SAVINGS PLAN Miscellaneous § 1690.15 Freezing an account—administrative holds. (a) The TSP may freeze (e.g...) Pursuant to a request from the Department of Justice under the Mandatory Victims Restitution Act; (3) Upon...

  7. 76 FR 16477 - General Reporting and Recordkeeping by Savings Associations and Savings and Loan Holding Companies

    Science.gov (United States)

    2011-03-23

    ... infocollection.comments@ots.treas.gov . OTS will post comments and the related ] index on the OTS Internet Site... each savings and loan holding company), 12 CFR part 226 (Regulation Z, truth in lending), 12 CFR...

  8. MONDAY: EPA to Hold U.S.-Mexico Border 2020 Conference

    Science.gov (United States)

    DALLAS - (Sept. 21, 2015) The U.S-Environmental Protection Agency (EPA) and the Mexican Environment and Natural Resources Secretariat (SEMARNAT) are holding their first biennial national coordinators meeting. The meeting is part of the Border 2020 U

  9. Determination of the column hold-up volume in supercritical fluid chromatography using nitrous-oxide.

    Science.gov (United States)

    Vajda, Péter; Guiochon, Georges

    2013-09-27

    This study introduces a new tracer that is useful for the determination of the hold-up time or volume of packed columns, particularly of those used in supercritical fluid chromatography. The thermodynamic void volume of three columns packed with different adsorbents were determined using the weight difference method. These void volumes were used as the reference point in the further discussion. The hold-up volumes of these columns were determined under dynamic conditions, using nitrous oxide dissolved in methanol as the hold-up time marker. Changes in the hold-up volumes of these columns were monitored during changes of the volumetric flow rate of pure supercritical carbon dioxide and of dilute mixtures of organic modifier and supercritical carbon dioxide. The results suggest significant methanol enrichment on the adsorbent surface.

  10. 78 FR 1265 - Dana Holding Corporation; Power Technologies Group Division; Including On-Site Leased Workers...

    Science.gov (United States)

    2013-01-08

    ... Employment and Training Administration Dana Holding Corporation; Power Technologies Group Division; Including... Technologies Group Division, Milwaukee, Wisconsin (subject firm). The worker group includes on-site leased... Company, Power Technologies Group Division, Milwaukee, Wisconsin, who were engaged in employment...

  11. Network analysis of pig movements: Loyalty patterns and contact chains of different holding types in Denmark

    DEFF Research Database (Denmark)

    Schulz, Jana; Boklund, Anette; Hisham Beshara Halasa, Tariq

    2017-01-01

    , the number of registered movements and the number of pigs moved. To identify holdings and holding types with potentially higher risk for introduction or spread of diseases via pig movements, we determined loyalty patterns, annual network components and contact chains for the 24 registered holding types...... time period. Weaner herds showed the highest level of in-loyalty, whereas we observed an intermediate level of in-loyalty for all breeding sites and for production herds. Boar stations, production herds and trade herds showed a high level of out-loyalty. Production herds constituted the highest......-going contact chains. Our results reflect the pyramidal structure of the underlying network. Based on the considered disease, the time frame for the calculation of network measurements needs to be adapted. Using these adapted values for loyalty and contact chains might help to identify holdings with high...

  12. Microbial sequencing analyses suggest the presence of a fecal veneer on indoor climbing wall holds.

    Science.gov (United States)

    Bräuer, S L; Vuono, D; Carmichael, M J; Pepe-Ranney, C; Strom, A; Rabinowitz, E; Buckley, D H; Zinder, S H

    2014-11-01

    Artificial climbing walls represent a unique indoor environment in which humans interact closely with a variety of surface types. Climbing wall holds may mediate transmission of organisms between individuals, and yet there are no studies that identify microorganisms present on these surfaces. In the current study, the microorganisms found on climbing wall holds were characterized by analysis of amplified SSU rRNA gene sequences. In contrast to many other studies of built environments, the majority of microorganisms on holds were most closely related to microbes annotated as being recovered from environmental sources, such as soil, with human skin also representing an important source. Regional patterns were evident as rRNA gene sequences from the marine cyanobacterium Prochlorococcus were abundant in gyms found within 16 km of the ocean. Enterobacteriaceae were present on 100 % of holds surveyed, and the members detected are commonly associated with fecal matter.

  13. 17 CFR 210.3A-05 - Special requirements as to public utility holding companies.

    Science.gov (United States)

    2010-04-01

    ... companies. There shall be shown in the consolidated balance sheet of a public utility holding company the... COMPANY ACT OF 1940, INVESTMENT ADVISERS ACT OF 1940, AND ENERGY POLICY AND CONSERVATION ACT OF...

  14. Diverse Presentation of Breath Holding Spells: Two Case Reports with Literature Review

    Directory of Open Access Journals (Sweden)

    Geetanjali Rathore

    2013-01-01

    Full Text Available Breath holding spells are a common and dramatic form of syncope and anoxic seizure in infancy. They are usually triggered by an emotional stimuli or minor trauma. Based on the color change, they are classified into 3 types, cyanotic, pallid, and mixed. Pallid breath holding spells result from exaggerated, vagally-mediated cardiac inhibition, whereas the more common, cyanotic breathholding spells are of more complex pathogenesis which is not completely understood. A detailed and accurate history is the mainstay of diagnosis. An EKG should be strongly considered to rule out long QT syndrome. Spontaneous resolution of breath-holding spells is usually seen, without any adverse developmental and intellectual sequelae. Rare cases of status epilepticus, prolonged asystole, and sudden death have been reported. Reassurance and education is the mainstay of therapy. Occasionally, pharmacologic intervention with iron, piracetam; atropine may be of benefit. Here we present 2 cases, one of each, pallid and cyanotic breath holding spells.

  15. POETICS OF THE ABSURD IN OLA ROTIMI’S HOLDING TALKS: A MANUAL FOR DIRECTORS

    Directory of Open Access Journals (Sweden)

    Dr. Odiri Solomon Ejeke

    2013-07-01

    Full Text Available The study analyzes Ola Rotimi’s Holding Talks directorially. In the analysis, the study places the play on its proper aesthetic base. The study is aimed at directors and theatre practitioners who might find this interpretation useful and as a guide for further practical theatre projects from a directorial perspective. The study consequently explains the thematic concepts of Holding Talks, relating the dramatic events to the Nigerian socio-political set up.

  16. Research on Precipitate Behavior during Holding Process of X80 Pipeline Steel

    Directory of Open Access Journals (Sweden)

    Niu Tao

    2016-01-01

    Full Text Available PTT (Precipitate-Temperature-Time curve of X80 pipeline steel was obtained by strain relaxation method. The evolution of precipitate particle size during holding process was simulated combined with kinetic calculation, and observed using TEM in the samples of industrial produced X80 steel with different holding time. It is revealed that the shape of PPT curve is typical “C” type with the nose temperature of 900°C and incubation time of about 5s. Kinetic calculation results show that the average particle size increases obviously with the increment of holding time. Meantime, after holding for 90s at 950°C, observation of industrial produced X80 steel reveals that the proportion of precipitate particles larger than 60nm increases dramatically, which basically agreed with the calculation results. Dissolved Nb can effectively reduce grain boundary mobility and retard recrystallization by solute drag effect. Therefore, it is strongly recommended to shorten the holding time without increasing holding temperature in industrial production, so that to reduce precipitate of Nb at high temperature, and increase the strength and toughness of steel.

  17. Cardiac Repolarization Changes in the Children with Breath-Holding Spells

    Science.gov (United States)

    Amoozgar, Hamid; Saleh, Fazl; Farhani, Nahal; Rafiei, Mohammad; Inaloo, Soroor; Asadipooya, Ali-Akbar

    2013-01-01

    Objective Breath-holding spells are known as benign attacks, frequencies of which decrease by the development of the autonomic nervous system. The present study aims to compare the electrocardiographic repolarization in children with breath-holding spells. Methods In this study, QT dispersion, QTc dispersion, T peak to T end dispersion, and P wave dispersion of the twelve-lead surface electrocardiography of fifty children who had breath-holding spells were measured and compared with normal children from April 2011 to August 2012. Findings Forty-four (88%) patients had cyanotic spells, while 6 (12%) had pallid spells. QTc dispersion was increased in the patients with breath-holding spells (148.2±33.1) compared to the healthy children (132±27.3) and the difference was statically significant (P = 0.01). Meanwhile, no statistically significant differences were observed between the patients and the control subjects regarding the other parameters (P > 0.05). Conclusion QTc dispersion was significantly increased in the patients with breath-holding spells compared to normal children and this is a sign of cardiac repolarization abnormality as well as the increased risk of cardiac arrhythmia in patients with breath-holding spells. PMID:24910749

  18. 78 FR 50410 - Black Bear Development Holdings, LLC; Supplemental Notice that Initial Market-Based Rate Filing...

    Science.gov (United States)

    2013-08-19

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Black Bear Development Holdings, LLC; Supplemental Notice that Initial... notice in the above-referenced proceeding of Black Bear Development Holdings, LLC's application...

  19. 77 FR 36041 - Nevada 5, Inc. and Oakland Transportation Holdings LLC-Control Exemption-GTR Leasing LLC and US...

    Science.gov (United States)

    2012-06-15

    ... Exemption--GTR Leasing LLC and US Rail Holdings LLC \\1\\ \\1\\ Applicants styled the transaction as a... (Rail Holdings), a Class III rail carrier, through Oakland's acquisition of GTR Leasing LLC (GTR),...

  20. Promise Without Presence: A New Approach To US Global Commitments

    Science.gov (United States)

    2016-02-11

    recruitment totals.  Charles A.  Henning , U.S. Military Stop  Loss Program: Key Questions and Answers (Washington, D.C.: Congressional Research Service, 2009), 1...Committee Holds Hearing on the Navy  Posture  in Review of the Proposed Fiscal 2016 Defense Authorization,  “March 10, 2015.  8 Timothy L. Ramey and Edward G...presence. A Reagan-Era Style Increase To meet increasing needs and global posture , the US could increase its defense budget heavily to re-arm the

  1. NANOTECHNOLOGY: A PROMISING CARRIER FOR INTRACELLULAR DRUG DELIVERY SYSTEM

    Directory of Open Access Journals (Sweden)

    Malakar Jadupati

    2012-02-01

    Full Text Available Nanotechnology is on its way to make a big impact in Biotech, Pharmaceutical and Medical diagnostics sciences. Nanotechnology holds a tremendous potential when it applied in the fields of drug delivery. In this review it has been discussed how nanotechnology can implemented to design formulations which can effectively carry drug molecule to the targeted cell organelles. Introduction of certain functional groups or addition of surface active agents may alter the characteristics of the carrier molecule, thus increasing the sensitivity to site selection of the carrier. It has been predicted that in the near future, nanoparticles with the ability of carrying multiple drug molecules, will be designed. They can maintain the delivery of drugs at specific time interval.

  2. Stem cells: a promising source for vascular regenerative medicine.

    Science.gov (United States)

    Rammal, Hassan; Harmouch, Chaza; Lataillade, Jean-Jacques; Laurent-Maquin, Dominique; Labrude, Pierre; Menu, Patrick; Kerdjoudj, Halima

    2014-12-15

    The rising and diversity of many human vascular diseases pose urgent needs for the development of novel therapeutics. Stem cell therapy represents a challenge in the medicine of the twenty-first century, an area where tissue engineering and regenerative medicine gather to provide promising treatments for a wide variety of diseases. Indeed, with their extensive regeneration potential and functional multilineage differentiation capacity, stem cells are now highlighted as promising cell sources for regenerative medicine. Their multilineage differentiation involves environmental factors such as biochemical, extracellular matrix coating, oxygen tension, and mechanical forces. In this review, we will focus on human stem cell sources and their applications in vascular regeneration. We will also discuss the different strategies used for their differentiation into both mature and functional smooth muscle and endothelial cells.

  3. Natural Flavonoids as Promising Analgesic Candidates: A Systematic Review.

    Science.gov (United States)

    Xiao, Xiao; Wang, Xiaoyu; Gui, Xuan; Chen, Lu; Huang, Baokang

    2016-11-01

    Due to the chemical structural diversity and various analgesic mechanisms, an increasing number of studies indicated that some flavonoids from medicinal plants could be promising candidates for new natural analgesic drugs, which attract high interests of advanced users and academic researchers. The aim of this systematic review is to report flavonoids and its derivatives as new analgesic candidates based on the pharmacological evidences. Sixty-four papers were found concerning the potential analgesic activity of 46 flavonoids. In this case, the evidence for analgesic activity of flavonoids and total flavonoids was investigated. Meanwhile, the corresponding analgesic mechanism of flavonoids was discussed by generalizing and analyzing the current publications. Based on this review, the conclusion can be drawn that some flavonoids are promising candidates for painful conditions and deserve particular attention in further research and development.

  4. The promise of 'sporting bodies' in phenomenological thinking

    DEFF Research Database (Denmark)

    Ravn, Susanne; Høffding, Simon

    2017-01-01

    For decades, qualitative researchers have used phenomenological thinking to advance reflections on particular kinds of lifeworlds. As emphasised by Allen-Collinson phenomenology offers a continuing promise of ‘bringing the body back in’ to theories on sport and physical activity. Turning to philo...... dancers and expert musicians, we indicate how qualitative researchers across the board, through the factual variation, can contribute to phenomenological thinking and thereby also strengthen their own theoretical foundation.......For decades, qualitative researchers have used phenomenological thinking to advance reflections on particular kinds of lifeworlds. As emphasised by Allen-Collinson phenomenology offers a continuing promise of ‘bringing the body back in’ to theories on sport and physical activity. Turning...... to philosophy, traditionally, phenomenologists have not paid much attention to qualitative research. Nevertheless, phenomenology does contain a strong emphasis on using ‘data’ or experiences from daily life and on drawing on data from medical pathology. In other words while qualitative researchers employ...

  5. Image is more than a uniform: the promise of assurance.

    Science.gov (United States)

    Wocial, Lucia D; Sego, Kelly; Rager, Carrie; Laubersheimer, Shellee; Everett, Linda Q

    2014-05-01

    The purpose of this qualitative study was to explore the meaning of the phrase "image of the nurse" in the context of the desired brand experience of assurance. A brand is a promise that lives in the minds of consumers. Nurses play a key role in delivering on the brand promise of a hospital. Using focus groups, the authors applied a deductive approach to generate data. Discussion transcripts were analyzed by establishing codes and identifying themes. The most frequent comment from participants was that for nurses to communicate assurance, they must 1st be clean, well groomed, and understated in overall appearance. Nurse behaviors that reassure patients include being present with patients, helping patients know what to expect, and demonstrating a consistent team approach. Overall appearance and behaviors define the image of nurses and contribute significantly to the brand of assurance.

  6. [Promising technologies of packed red blood cells production and storage].

    Science.gov (United States)

    Maksimov, A G; Golota, A S; Krassiĭ, A B

    2013-10-01

    The current article is dedicated to promising technologies of packed red blood cells production and storage. The following new technical approaches are presented: (1) erythrocytes storage in strict anaerobic argon-hydrogen environment, (2) lyophilization of erythrocyte suspension by its atomization in nitrogen gas, (3) lyophilization of erythrocytes by directional freezing under the influence of radio frequency radiation, (4) automated pharming of antigen free packed red blood cells from progenitor cell directly at the battlefield.

  7. KirCII- promising tool for polyketide diversification

    DEFF Research Database (Denmark)

    Musiol-Kroll, Ewa Maria; Härtner, Thomas; Kulik, Andreas

    2014-01-01

    Kirromycin is produced by Streptomyces collinus Tü 365. This compound is synthesized by a large assembly line of type I polyketide synthases and non-ribosomal peptide synthetases (PKS I/NRPS), encoded by the genes kirAI-kirAVI and kirB. The PKSs KirAI-KirAV have no acyltransferase domains integra...... introducing the non-native substrates in an in vivo context. Thus, KirCII represents a promising tool for polyketide diversification....

  8. Understanding the promises and premises of online health platforms

    OpenAIRE

    van Dijck, J.; Poell, T.

    2016-01-01

    This article investigates the claims and complexities involved in the platform-based economics of health and fitness apps. We examine a double-edged logic inscribed in these platforms, promising to offer personal solutions to medical problems while also contributing to the public good. On the one hand, online platforms serve as personalized data-driven services to their customers. On the other hand, they allegedly serve public interests, such as medical research or health education. In doing ...

  9. Awareness of Open Source Software (OSS: Promises, Reality and Future

    Directory of Open Access Journals (Sweden)

    Anil (Student of M.Tech.(CSE

    2011-10-01

    Full Text Available Open source is a development method for software that harnessesthe power of distributed peer review and transparency of process.The Open Source Initiative Approved License trademark andprogram creates a nexus of trust around which developers, users,corporations and governments can organize open sourcecooperation. The promise of open source is better quality, higherreliability, more flexibility, lower cost, and an end to predatoryvendor lock-in.

  10. Food biopreservation: Promising strategies using bacteriocins, bacteriophages and endolysins

    OpenAIRE

    García Suárez, María Pilar; Rodríguez,Lorena; Rodríguez González, Ana; Martínez Fernández, Beatriz

    2010-01-01

    The interest in biopreservation of food has prompted the quest for new natural antimicrobial compounds from different origins. Bacteriocins have been widely recognized as natural food biopreservatives but lastest advances on bateriocin biology have opened new fields to explore. On the contrary, the use of bacteriophages and endolysins has only been considered in the last five years and recent developments have produced promising perspectives. This review provides an overview of the current an...

  11. NOTCH INHIBITION AS A PROMISING NEW APPROACH TO CANCER THERAPY

    OpenAIRE

    Purow, Benjamin

    2012-01-01

    The Notch pathway powerfully influences stem cell maintenance, development and cell fate and is increasingly recognized for the key roles it plays in cancer. Notch promotes cell survival, angiogenesis and treatment resistance in numerous cancers, making it a promising target for cancer therapy. It also crosstalks with other critical oncogenes, providing a means to affect numerous signaling pathways with one intervention. While the gamma-secretaase inhibitors are the only form of Notch inhibit...

  12. Discovery AND Therapeutic Promise OF Selective Androgen Receptor Modulators

    Science.gov (United States)

    Chen, Jiyun; Kim, Juhyun; Dalton, James T.

    2007-01-01

    Androgens are essential for male development and the maintenance of male secondary characteristics, such as bone mass, muscle mass, body composition, and spermatogenesis. The main disadvantages of steroidal androgens are their undesirable physicochemical and pharmacokinetic properties. The recent discovery of nonsteroidal selective androgen receptor modulators (SARMs) provides a promising alternative for testosterone replacement therapies with advantages including oral bioavailability, flexibility of structural modification, androgen receptor specificity, tissue selectivity, and the lack of steroid-related side effects. PMID:15994457

  13. Discovery and therapeutic promise of selective androgen receptor modulators.

    Science.gov (United States)

    Chen, Jiyun; Kim, Juhyun; Dalton, James T

    2005-06-01

    Androgens are essential for male development and the maintenance of male secondary characteristics, such as bone mass, muscle mass, body composition, and spermatogenesis. The main disadvantages of steroidal androgens are their undesirable physicochemical and pharmacokinetic properties. The recent discovery of nonsteroidal selective androgen receptor modulators (SARMs) provides a promising alternative for testosterone replacement therapies with advantages including oral bioavailability, flexibility of structural modification, androgen receptor specificity, tissue selectivity, and the lack of steroid-related side effects.

  14. Network analysis of pig movements: Loyalty patterns and contact chains of different holding types in Denmark.

    Science.gov (United States)

    Schulz, Jana; Boklund, Anette; Halasa, Tariq H B; Toft, Nils; Lentz, Hartmut H K

    2017-01-01

    Understanding animal movements is an important factor for the development of meaningful surveillance and control programs, but also for the development of disease spread models. We analysed the Danish pig movement network using static and temporal network analysis tools to provide deeper insight in the connection between holdings dealing with pigs, such as breeding and multiplier herds, production herds, slaughterhouses or traders. Pig movements, which occurred between 1st January 2006 and 31st December 2015 in Denmark, were summarized to investigate temporal trends such as the number of active holdings, the number of registered movements and the number of pigs moved. To identify holdings and holding types with potentially higher risk for introduction or spread of diseases via pig movements, we determined loyalty patterns, annual network components and contact chains for the 24 registered holding types. The total number of active holdings as well as the number of pig movements decreased during the study period while the holding sizes increased. Around 60-90% of connections between two pig holdings were present in two consecutive years and around one third of the connections persisted within the considered time period. Weaner herds showed the highest level of in-loyalty, whereas we observed an intermediate level of in-loyalty for all breeding sites and for production herds. Boar stations, production herds and trade herds showed a high level of out-loyalty. Production herds constituted the highest proportion of holdings in the largest strongly connected component. All production sites showed low levels of in-going contact chains and we observed a high level of out-going contact chain for breeding and multiplier herds. Except for livestock auctions, all transit sites also showed low levels of out-going contact chains. Our results reflect the pyramidal structure of the underlying network. Based on the considered disease, the time frame for the calculation of network

  15. Yielding and its adaptability of several promising bulk cocoa clones

    Directory of Open Access Journals (Sweden)

    Dedy Suhendi

    2005-05-01

    Full Text Available Yielding and its adaptability are considered to be an important criteria for clones recommendation. An experiment to evaluate yield and its adaptability of several promising bulk cocoa clones has been executed during 1996—2003 in three locations having different altitude and type of climate, consisted of Jatirono(450 m asl., B type of climate, Kalisepanjang (275 m asl., C type of climate and Kalitelepak (145 m asl., B type of climate. Randomized completely block design (RCBD was used in each location with 14 promising clones and four replications. Recommended clones of ICS 60 and GC 7 were used as standard. The promising clones were originated from mother trees selection with the main criteria of yield. Observations were conducted on yield and its components as well as bean characteristics. Determination of adaptability of each clone by using yield performance and its stability. Statistical analysis was done by using combined analysis. The results showed that KW 30 and KW 48 perform higher yield (2.3 ton/ha than that of standard clone (1.7 ton/ha as well as consistant yield stability between location and over years. There for, the two clones performed good adaptability. KW 30 and KW 48 also perform good yield components, and high percentage of fat content i.e 55%. So, those clones are potential to be recommended for commercial planting materials. Key words : bulk cocoa, yield, clone, stability, adaptability.

  16. 41 CFR 102-37.115 - May a holding agency be reimbursed for costs incurred incident to a donation?

    Science.gov (United States)

    2010-07-01

    ... reimbursed for costs incurred incident to a donation? 102-37.115 Section 102-37.115 Public Contracts and... REGULATION PERSONAL PROPERTY 37-DONATION OF SURPLUS PERSONAL PROPERTY Holding Agency § 102-37.115 May a holding agency be reimbursed for costs incurred incident to a donation? Yes, you, as a holding agency,...

  17. 26 CFR 301.6035-1 - Returns of officers, directors, and shareholders of foreign personal holding companies.

    Science.gov (United States)

    2010-04-01

    ... shareholders of foreign personal holding companies. 301.6035-1 Section 301.6035-1 Internal Revenue INTERNAL... shareholders of foreign personal holding companies. For provisions relating to the requirement of returns by officers, directors, and shareholders of foreign personal holding companies, see §§ 1.6035-1 to...

  18. 18 CFR 292.602 - Exemption to qualifying facilities from the Public Utility Holding Company Act and certain State...

    Science.gov (United States)

    2010-04-01

    ... facilities from the Public Utility Holding Company Act and certain State law and regulation. 292.602 Section... from the Public Utility Holding Company Act and certain State law and regulation. Link to an amendment... qualifying facilities from the Public Utility Holding Company Act of 2005 and certain State laws and...

  19. 76 FR 32226 - Russell Newman, Inc., a Subsdiary of RNA Holdings, LLC, Including On-Site Leased Workers From...

    Science.gov (United States)

    2011-06-03

    ... Employment and Training Administration Russell Newman, Inc., a Subsdiary of RNA Holdings, LLC, Including On...; Russell Newman, Inc., a Subsidiary of RNA Holdings, LLC, Great Barrington, MA; RNA Holdings, LLC, a... Adjustment Assistance on March 3, 2011, applicable to workers of Russell Newman, Inc., a subsidiary of RNA...

  20. 12 CFR 225.103 - Bank holding company acquiring stock by dividends, stock splits or exercise of rights.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Bank holding company acquiring stock by... holding company acquiring stock by dividends, stock splits or exercise of rights. (a) The Board of... SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM BANK HOLDING COMPANIES AND CHANGE...

  1. Holding Water in the Landscape; striking a balance between food production and healthy catchment function

    Science.gov (United States)

    Quinn, Paul; Wilkinson, Mark; Stutter, Marc; Adams, Russell

    2015-04-01

    Here it is proposed that ~5 % of the rural landscape could be modified to hold water during storm events. Hence ~95% of land remains for food production, commercial forestry and amenity. This is a catchment scale commitment to sustainably reducing flood and drought risk, improving water quality, biodiversity and thereby climate proofing our catchments. The farmed landscape has intensified and as a result, runoff rates are no longer in balance with the catchment needs, which in turn contributes to floods, droughts and water pollution problems. The loss of infiltration rates, soil water holding capacity and the increase in ditches and drains through intense farming has resulted in a reduction of the overall water holding capacity of the landscape, therefore deeper soil and aquifer recharge rates are lower. However, adequate raw water supply and food production is also vital. Here we consider how ~5% of productive land could be used to physically hold water during and after storms. This is a simple philosophy for water stewardship that could be delivered by farmers and land managers themselves. In this poster we consider a 'treatment train' of mitigation in headwaters by the construction of:- Rural SuDs - by creating swales, bunds and grassy filters; Buffer Strips - (designed to hold water); The Ditch of The Future - by creating the prime location for holding water and recovering lost top soil and finally the better use of Small Headwater Floodplains - by storing flood water, creating wetlands, planting new forest, installing woody debris and new habitats. We present examples of where and how these measures have been installed and show the cost-effectiveness of temporarily holding storm runoff in several case study catchments taken from the UK.

  2. Risk of Neurological Insult in Competitive Deep Breath-Hold Diving.

    Science.gov (United States)

    Tetzlaff, Kay; Schöppenthau, Holger; Schipke, Jochen D

    2017-02-01

    It has been widely believed that tissue nitrogen uptake from the lungs during breath-hold diving would be insufficient to cause decompression stress in humans. With competitive free diving, however, diving depths have been ever increasing over the past decades. A case is presented of a competitive free-diving athlete who suffered stroke-like symptoms after surfacing from his last dive of a series of 3 deep breath-hold dives. A literature and Web search was performed to screen for similar cases of subjects with serious neurological symptoms after deep breath-hold dives. A previously healthy 31-y-old athlete experienced right-sided motor weakness and difficulty speaking immediately after surfacing from a breathhold dive to a depth of 100 m. He had performed 2 preceding breath-hold dives to that depth with surface intervals of only 15 min. The presentation of symptoms and neuroimaging findings supported a clinical diagnosis of stroke. Three more cases of neurological insults were retrieved by literature and Web search; in all cases the athletes presented with stroke-like symptoms after single breath-hold dives of depths exceeding 100 m. Two of these cases only had a short delay to recompression treatment and completely recovered from the insult. This report highlights the possibility of neurological insult, eg, stroke, due to cerebral arterial gas embolism as a consequence of decompression stress after deep breath-hold dives. Thus, stroke as a clinical presentation of cerebral arterial gas embolism should be considered another risk of extreme breath-hold diving.

  3. The cardiac dose-sparing benefits of deep inspiration breath-hold in left breast irradiation: a systematic review

    Energy Technology Data Exchange (ETDEWEB)

    Smyth, Lloyd M, E-mail: lloyd.smyth@epworth.org.au [Epworth Radiation Oncology, Level 4, The Epworth Centre, Richmond, Victoria (Australia); Department of Medical Imaging and Radiation Sciences, Faculty of Medicine, School of Biomedical Sciences, Nursing and Health Sciences, Monash University, Clayton, Victoria (Australia); Knight, Kellie A [Department of Medical Imaging and Radiation Sciences, Faculty of Medicine, School of Biomedical Sciences, Nursing and Health Sciences, Monash University, Clayton, Victoria (Australia); Aarons, Yolanda K; Wasiak, Jason [Epworth Radiation Oncology, Level 4, The Epworth Centre, Richmond, Victoria (Australia)

    2015-03-15

    Despite technical advancements in breast radiation therapy, cardiac structures are still subject to significant levels of irradiation. As the use of adjuvant radiation therapy after breast-conserving surgery continues to improve survival for early breast cancer patients, the associated radiation-induced cardiac toxicities become increasingly relevant. Our primary aim was to evaluate the cardiac-sparing benefits of the deep inspiration breath-hold (DIBH) technique. An electronic literature search of the PubMed database from 1966 to July 2014 was used to identify articles published in English relating to the dosimetric benefits of DIBH. Studies comparing the mean heart dose of DIBH and free breathing treatment plans for left breast cancer patients were eligible to be included in the review. Studies evaluating the reproducibility and stability of the DIBH technique were also reviewed. Ten studies provided data on the benefits of DIBH during left breast irradiation. From these studies, DIBH reduced the mean heart dose by up to 3.4 Gy when compared to a free breathing approach. Four studies reported that the DIBH technique was stable and reproducible on a daily basis. According to current estimates of the excess cardiac toxicity associated with radiation therapy, a 3.4 Gy reduction in mean heart dose is equivalent to a 13.6% reduction in the projected increase in risk of heart disease. DIBH is a reproducible and stable technique for left breast irradiation showing significant promise in reducing the late cardiac toxicities associated with radiation therapy.

  4. Analysis of the baseline survey on the prevalence of Salmonella in holdings with breeding pigs in the EU, 2008

    DEFF Research Database (Denmark)

    Bole-Hribovšek, Vojislava; Chriél, Mariann; Davies, Robert;

    Salmonella is a major cause of food-borne illness in humans. Farm animals and foods of animal origin are important sources of human Salmonella infections. This European Union-wide Salmonella baseline survey was conducted in 2008 in holdings with breeding pigs. A total of 1,609 holdings housing...... and selling mainly breeding pigs (breeding holdings) and 3,508 holdings housing breeding pigs and selling mainly pigs for fattening or slaughter (production holdings) from 24 European Union Member States and two non-Member States, were randomly selected and included in the survey. In each selected breeding...

  5. Influence of Holding Time on Shape Recovery in a Polyurethane Shape-Memory Polymer

    Science.gov (United States)

    Santiago, David; Ferrando, Francesc; De la Flor, Silvia

    2014-07-01

    Shape-memory polymers have attracted a lot of interest in recent years. A shape-memory polymer can be deformed and fixed into a temporary shape and subsequently made to recover its original shape when a suitable stimulus is applied. This is accomplished by means of a thermomechanical cycle called programming. Programming can be performed in a stress- or strain-controlled mode. The thermomechanical conditions of the programming affect shape-memory properties differently in each programming mode. One of the parameters which significantly affects shape-memory properties in a stress-controlled procedure is stress-holding time ( t H) at high temperature. This paper studies how stress-holding time affects the most significant shape-memory properties under successive thermomechanical cycles. The experiments were conducted using two different programming temperatures in the vicinity of the T g. The shape-recovery ratio decreased dramatically with cycling even when the holding time was just a few seconds, however, the impact of the stress-holding time depends on the temperature at which it has been applied. Shape-fixity ratio and switching temperature were also studied, but stress-holding time and successive cycles do not seem to affect either of these factors.

  6. Development of inclusions in 3104 alloy melt during heating and holding treatments

    Institute of Scientific and Technical Information of China (English)

    Xiao-xiong Luo; Hai-tao Zhang; Xing Han; Shi-jie Guo; Dan-dan Chen; Jian-zhong Cui; Hiromi Nagaumi

    2016-01-01

    Developments in the contents of different typical inclusions in 3104 alloy melt were described during heating and holding proc-essing. The settling process of inclusion particles was investigated by measuring the contents of inclusions in the surface, center, and bottom layers of the molten metal. In the results, main inclusions observed and determined by Prefil and PoDFA methods are MgO, Al2O3, spinel (MgAl2O4), and TiB2 particles or thin films. It is found that some small particles of Al2O3 and MgO are transformed into spinel particles, and the formation rate increases as the temperature and the holding period of melt increase. The content of inclusions increases from 3.37 mm2×kg-1 to 7.54 mm2×kg-1 and then decreases to 3.08 mm2×kg−1 after holding for 90 min. This is attributed to a settling phenomenon and a significant increase in settling velocity after holding for 60 min. The content of inclusion particles decreases by means of settlement and flo-tation in liquid aluminum with an increase in holding time. The theoretical analysis and experiment results are in essential agreement with those from industrial production.

  7. Holding time effect of pack carburizing on fatigue characteristic of v-notch shaft steel specimens

    Science.gov (United States)

    Supriyono, Jamasri

    2017-06-01

    The objective of this research is to study the effect of the holding times of pack carburizing process on fatigue characteristic of v-notch shaft steel specimens. The carbon source was taken from charcoal of unused mahogany. The holding times were 2, 3 and 4 hours. The fatigue tests were conducted on rotary bending machine. The specimens were made of low carbon steel of 0.17% carbon content. Pack carburizing was conducted to the specimens at 930°C. V-notch was made to present the stress concentration on the specimens. To see the effects of the carburizing in changing the material properties, the micro-structures and hardness tests along the cross sectional area of the specimens were carried out. The results showed that the holding time of the carburizing process influences the fatigue strength of the material. The longer the holding time will be the higher the fatigue strength. The increase of the fatigue strength is due to the carbon content on the surface. It was confirmed by the micro-structures and the hardness tests results. The cross sectional area of carburized material is divided into two zones i.e. surface zone and core zone. The surface zone consists of hypereutectoid, eutectoid, and hypo eutectoid sub-zone. The core zone is the same as raw material. The longer the holding time will be the deeper the surface zone.

  8. Progress Report on Long Hold Time Creep Fatigue of Alloy 617 at 850°C

    Energy Technology Data Exchange (ETDEWEB)

    Carroll, Laura Jill [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2015-10-01

    Alloy 617 is the leading candidate material for an intermediate heat exchanger for the very high temperature reactor. To evaluate the behavior of this material in the expected service conditions, strain-controlled cyclic tests that include long hold times up to 240 minutes at maximum tensile strain were conducted at 850°C. In terms of the total number of cycles to failure, the fatigue resistance decreased when a hold time was added at peak tensile strain. Increases in the tensile hold duration degraded the creep-fatigue resistance, at least to the investigated strain controlled hold time of up to 60 minutes at the 0.3% strain range and 240 minutes at the 1.0% strain range. The creep-fatigue deformation mode is considered relative to the lack of saturation, or continually decreasing number of cycles to failure with increasing hold times. Additionally, preliminary values from the 850°C creep-fatigue data are calculated for the creep-fatigue damage diagram and have higher values of creep damage than those from tests at 950°C.

  9. Control of grip force and vertical posture while holding an object and being perturbed.

    Science.gov (United States)

    Chen, Bing; Lee, Yun-Ju; Aruin, Alexander S

    2016-11-01

    We investigated motor control perspectives of coordinating maintenance of posture and application of grip force when holding an object and being perturbed. Ten subjects stood on the force platform holding an instrumented object in their dominant hand and were exposed to an external perturbation applied to their shoulders. Task demands were manipulated by positioning a slippery cap on top of the instrumented object. Grip force applied to the object, the object acceleration and the center of pressure (COP) were recorded and analyzed during the time intervals typical for the anticipatory (APA) and compensatory (CPA) components of postural control. Onsets of grip force were seen before the onsets of the COP displacement and initiation of movements of the handheld object during the APA phase of postural control, while the onsets of maximum grip force preceded the maximum COP displacement during the CPA phase. When the task demands increased by holding a handheld object with the slippery cap, subjects tended to generate grip force earlier and of a smaller magnitude; also, the COP displacement in the APA phase was smaller as compared to holding a handheld object only. The outcome provides a foundation for future studies of maintenance of vertical posture in people with impairments of balance and grip force control when holding an object and being perturbed.

  10. Effects of holding time and measurement error on culturing Legionella in environmental water samples.

    Science.gov (United States)

    Flanders, W Dana; Kirkland, Kimberly H; Shelton, Brian G

    2014-10-01

    Outbreaks of Legionnaires' disease require environmental testing of water samples from potentially implicated building water systems to identify the source of exposure. A previous study reports a large impact on Legionella sample results due to shipping and delays in sample processing. Specifically, this same study, without accounting for measurement error, reports more than half of shipped samples tested had Legionella levels that arbitrarily changed up or down by one or more logs, and the authors attribute this result to shipping time. Accordingly, we conducted a study to determine the effects of sample holding/shipping time on Legionella sample results while taking into account measurement error, which has previously not been addressed. We analyzed 159 samples, each split into 16 aliquots, of which one-half (8) were processed promptly after collection. The remaining half (8) were processed the following day to assess impact of holding/shipping time. A total of 2544 samples were analyzed including replicates. After accounting for inherent measurement error, we found that the effect of holding time on observed Legionella counts was small and should have no practical impact on interpretation of results. Holding samples increased the root mean squared error by only about 3-8%. Notably, for only one of 159 samples, did the average of the 8 replicate counts change by 1 log. Thus, our findings do not support the hypothesis of frequent, significant (≥= 1 log10 unit) Legionella colony count changes due to holding.

  11. GMI High Frequency Antenna Pattern Correction Update Based on GPM Inertial Hold and Comparison with ATMS

    Science.gov (United States)

    Draper, David W.

    2015-01-01

    In an inertial hold, the spacecraft does not attempt to maintain geodetic pointing, but rather maintains the same inertial position throughout the orbit. The result is that the spacecraft appears to pitch from 0 to 360 degrees around the orbit. Two inertial holds were performed with the GPM spacecraft: 1) May 20, 2014 16:48:31 UTC-18:21:04 UTC, spacecraft flying forward +X (0yaw), pitch from 55 degrees (FCS) to 415 degrees (FCS) over the orbit2) Dec 9, 2014 01:30:00 UTC-03:02:32 UTC, spacecraft flying backward X (180yaw), pitch from 0 degrees (FCS) to 360 degrees (FCS) over the orbitThe inertial hold affords a view of the earth through the antenna backlobe. The antenna spillover correction may be evaluated based on the inertial hold data.The current antenna pattern correction does not correct for spillover in the 166 and 183 GHz channels. The two inertial holds both demonstrate that there is significant spillover from the 166 and 183 GHz channels. By not correcting the spillover, the 166 and 183 GHz channels are biased low by about 1.8 to 3K. We propose to update the GMI calibration algorithm with the spill-over correction presented in this document for 166 GHz and 183 GHz.

  12. Mean heart dose variation over a course of breath-holding breast cancer radiotherapy.

    Science.gov (United States)

    Dunkerley, Nicolle; Bartlett, Frederick R; Kirby, Anna M; Evans, Philip M; Donovan, Ellen M

    2016-11-01

    The purpose of the work was to estimate the dose received by the heart throughout a course of breath-holding breast radiotherapy. 113 cone-beam CT (CBCT) scans were acquired for 20 patients treated within the HeartSpare 1A study, in which both an active breathing control (ABC) device and a voluntary breath-hold (VBH) method were used. Predicted mean heart doses were obtained from treatment plans. CBCT scans were imported into a treatment planning system, heart outlines defined, images registered to the CT planning scan and mean heart dose recorded. Two observers outlined two cases three times each to assess interobserver and intraobserver variation. There were no statistically significant differences between ABC and VBH heart dose data from CT planning scans, or in the CBCT-based estimates of heart dose, and no effect from the order of the breath-hold method. Variation in mean heart dose per fraction over the three imaged fractions was heart doses were heart dose was at an acceptable level over the duration of breath-holding radiotherapy and was well predicted by the planning system. Advances in knowledge: Mean heart dose was not adversely affected by fraction-to-fraction variations throughout a course of heart-sparing radiotherapy using two well-established breath-holding methods.

  13. Design, challenge, and promise of stimuli-responsive nanoantibiotics

    Science.gov (United States)

    Edson, Julius A.; Kwon, Young Jik

    2016-10-01

    Over the past few years, there have been calls for novel antimicrobials to combat the rise of drug-resistant bacteria. While some promising new discoveries have met this call, it is not nearly enough. The major problem is that although these new promising antimicrobials serve as a short-term solution, they lack the potential to provide a long-term solution. The conventional method of creating new antibiotics relies heavily on the discovery of an antimicrobial compound from another microbe. This paradigm of development is flawed due to the fact that microbes can easily transfer a resistant mechanism if faced with an environmental pressure. Furthermore, there has been some evidence to indicate that the environment of the microbe can provide a hint as to their virulence. Because of this, the use of materials with antimicrobial properties has been garnering interest. Nanoantibiotics, (nAbts), provide a new way to circumvent the current paradigm of antimicrobial discovery and presents a novel mechanism of attack not found in microbes yet; which may lead to a longer-term solution against drug-resistance formation. This allows for environment-specific activation and efficacy of the nAbts but may also open up and create new design methods for various applications. These nAbts provide promise, but there is still ample work to be done in their development. This review looks at possible ways of improving and optimizing nAbts by making them stimuli-responsive, then consider the challenges ahead, and industrial applications.[Figure not available: see fulltext.

  14. Design, challenge, and promise of stimuli-responsive nanoantibiotics.

    Science.gov (United States)

    Edson, Julius A; Kwon, Young Jik

    2016-01-01

    Over the past few years, there have been calls for novel antimicrobials to combat the rise of drug-resistant bacteria. While some promising new discoveries have met this call, it is not nearly enough. The major problem is that although these new promising antimicrobials serve as a short-term solution, they lack the potential to provide a long-term solution. The conventional method of creating new antibiotics relies heavily on the discovery of an antimicrobial compound from another microbe. This paradigm of development is flawed due to the fact that microbes can easily transfer a resistant mechanism if faced with an environmental pressure. Furthermore, there has been some evidence to indicate that the environment of the microbe can provide a hint as to their virulence. Because of this, the use of materials with antimicrobial properties has been garnering interest. Nanoantibiotics, (nAbts), provide a new way to circumvent the current paradigm of antimicrobial discovery and presents a novel mechanism of attack not found in microbes yet; which may lead to a longer-term solution against drug-resistance formation. This allows for environment-specific activation and efficacy of the nAbts but may also open up and create new design methods for various applications. These nAbts provide promise, but there is still ample work to be done in their development. This review looks at possible ways of improving and optimizing nAbts by making them stimuli-responsive, then consider the challenges ahead, and industrial applications.Graphical abstractA graphic detailing how the current paradigm of antibiotic discovery can be circumvented by the use of nanoantibiotics.

  15. Single breath-hold assessment of cardiac function using an accelerated 3D single breath-hold acquisition technique - comparison of an intravascular and extravascular contrast agent

    Directory of Open Access Journals (Sweden)

    Makowski Marcus R

    2012-07-01

    Full Text Available Abstract Background Cardiovascular magnetic resonance (CMR is the current gold standard for the assessment of left ventricular (LV function. Repeated breath-holds are needed for standard multi-slice 2D cine steady-state free precession sequences (M2D-SSFP. Accelerated single breath-hold techniques suffer from low contrast between blood pool and myocardium. In this study an intravascular contrast agent was prospectively compared to an extravascular contrast agent for the assessment of LV function using a single-breath-hold 3D-whole-heart cine SSFP sequence (3D-SSFP. Methods LV function was assessed in fourteen patients on a 1.5 T MR-scanner (Philips Healthcare using 32-channel coil technology. Patients were investigated twice using a 3D-SSFP sequence (acquisition time 18–25 s after Gadopentetate dimeglumine (GdD, day 1 and Gadofosveset trisodium (GdT, day 2 administration. Image acquisition was accelerated using sensitivity encoding in both phase encoding directions (4xSENSE. CNR and BMC were both measured between blood and myocardium. The CNR incorporated noise measurements, while the BMC represented the coeffiancy between the signal from blood and myocardium [1]. Contrast to noise ratio (CNR, blood to myocardium contrast (BMC, image quality, LV functional parameters and intra-/interobserver variability were compared. A M2D-SSFP sequence was used as a reference standard on both days. Results All 3D-SSFP sequences were successfully acquired within one breath-hold after GdD and GdT administration. CNR and BMC were significantly (p vs. 23.7 and regression analysis showed a stronger correlation to the reference standard (R2 = 0.92 vs. R2 = 0.71, compared to 3D-SSFP with GdD. Conclusions A single-breath-hold 3D-whole-heart cine SSFP sequence in combination with 32-channel technology and an intravascular contrast agent allows for the accurate and fast assessment of LV function. Trial registration The study was approved by the local

  16. The effect of holding times of whole blood and its components during processing on in vitro and in vivo quality.

    Science.gov (United States)

    van der Meer, Pieter F; de Korte, Dirk

    2015-01-01

    Whole blood is not usually collected close to the processing site, which results in a holding time between collection and processing. In some countries, the holding time is limited to 8 hours, after which the units are cooled, rendering them useless for platelet preparation. Other countries allow a 24-hour (“overnight”) ambient hold to allow platelet preparation. The impact of this holding time on subsequent blood components will be reviewed in this article. In addition, there are various “in-process” holding times that further prolong the time before the final blood component is ready. Particularly, these in-process holding times are not well defined and poorly controlled,but can nevertheless affect the biochemical and functional characteristics of blood components. Furthermore, current, non–evidence-based, guidelines have restricted the length of some of these holding times. This article summarizes the evidence and fills gaps where evidence is lacking.

  17. Cyclodextrin nanoassemblies: a promising tool for drug delivery.

    Science.gov (United States)

    Bonnet, Véronique; Gervaise, Cédric; Djedaïni-Pilard, Florence; Furlan, Aurélien; Sarazin, Catherine

    2015-09-01

    Among the biodegradable and nontoxic compounds that can form nanoparticles for drug delivery, amphiphilic cyclodextrins are very promising. Apart from ionic cyclodextrins, which have been extensively studied and reviewed because of their application in gene delivery, our purpose is to provide a clear description of the supramolecular assemblies of nonionic amphiphilic cyclodextrins, which can form nanoassemblies for controlled drug release. Moreover, we focus on the relationship between their structure and physicochemical characteristics, which is crucial for self assembly and drug delivery. We also highlight the importance of the nanoparticle technology preparation for the stability and application of this nanodevice.

  18. E-health technologies show promise in developing countries.

    Science.gov (United States)

    Blaya, Joaquin A; Fraser, Hamish S F; Holt, Brian

    2010-02-01

    Is there any evidence that e-health-using information technology to manage patient care-can have a positive impact in developing countries? Our systematic review of evaluations of e-health implementations in developing countries found that systems that improve communication between institutions, assist in ordering and managing medications, and help monitor and detect patients who might abandon care show promise. Evaluations of personal digital assistants and mobile devices convincingly demonstrate that such devices can be very effective in improving data collection time and quality. Donors and funders should require and sponsor outside evaluations to ensure that future e-health investments are well-targeted.

  19. Back to the future: bacteriophages as promising therapeutic tools.

    Science.gov (United States)

    Domingo-Calap, P; Georgel, P; Bahram, S

    2016-03-01

    Bacteriophages (phages), natural predators of bacteria, are becoming increasingly attractive in medical and pharmaceutical applications. After their discovery almost a century ago, they have been particularly instrumental in the comprehension of basic molecular biology and genetics processes. The more recent emergence of multi-drug-resistant bacteria requires novel therapeutic strategies, and phages are being (re)considered as promising potential antibacterial tools. Furthermore, phages are also used for other purposes, e.g. vaccine production, gene/drug carriers, bacterial detection and typing. These new alternative approaches using phages are of major interest and have allowed unexpected developments, from the decipherment of fundamental biological processes to potential clinical applications.

  20. The microeconomics of personalized medicine: today's challenge and tomorrow's promise.

    Science.gov (United States)

    Davis, Jerel C; Furstenthal, Laura; Desai, Amar A; Norris, Troy; Sutaria, Saumya; Fleming, Edd; Ma, Philip

    2009-04-01

    'Personalized medicine' promises to increase the quality of clinical care and, in some cases, decrease health-care costs. Despite this, only a handful of diagnostic tests have made it to market, with mixed success. Historically, the challenges in this field were scientific. However, as discussed in this article, with the maturation of the '-omics' sciences, it now seems that the major barriers are increasingly related to economics. Overcoming the poor microeconomic alignment of incentives among key stakeholders is therefore crucial to catalysing the further development and adoption of personalized medicine, and we propose several actions that could help achieve this goal.

  1. The promises and facts of emergent strategy in public management

    DEFF Research Database (Denmark)

    Aagaard, Peter

    Public managers are experiencing a growing demand for innovation. One of the promising approaches to instigating innovation is that of emergent strategic patterns (ESPs). According to the literature, the institutional barriers and drivers of ESPs are shaped by the two dominant public management...... models, NPM (the barriers) and governance (the drivers). However, based on an empirical case study of the institutional barriers and drivers for ESPs in the Danish Crime Prevention Council, this article concludes that ESPs are in fact enabled by a much more mixed management model....

  2. The promise of post-menopausal pregnancy (PMP).

    Science.gov (United States)

    Landau, Ruth

    2004-01-01

    Postmenopausal pregnancy (PMP) is presented as a means of alleviating women's suffering by helping them realize their wish for a child of their "own." The availability of IVF technology and oocyte donation, both necessary for PMP, create the illusion of unlimited female fertility. The aim of this paper is twofold: (1) to examine the psychosocial, health, and ethical aspects of PMP; and (2) to answer the question of whether PMP's promise of unlimited fertility really offers more personal freedom and control for women. The paper concludes that PMP seems to increase, rather than to decrease, human suffering.

  3. The promises and facts of emergent strategy in public management

    DEFF Research Database (Denmark)

    Aagaard, Peter

    Public managers are experiencing a growing demand for innovation. One of the promising approaches to instigating innovation is that of emergent strategic patterns (ESPs). According to the literature, the institutional barriers and drivers of ESPs are shaped by the two dominant public management m...... models, NPM (the barriers) and governance (the drivers). However, based on an empirical case study of the institutional barriers and drivers for ESPs in the Danish Crime Prevention Council, this article concludes that ESPs are in fact enabled by a much more mixed management model....

  4. Porous liquids: a promising class of media for gas separation.

    Science.gov (United States)

    Zhang, Jinshui; Chai, Song-Hai; Qiao, Zhen-An; Mahurin, Shannon M; Chen, Jihua; Fang, Youxing; Wan, Shun; Nelson, Kimberly; Zhang, Pengfei; Dai, Sheng

    2015-01-12

    A porous liquid containing empty cavities has been successfully fabricated by surface engineering of hollow structures with suitable corona and canopy species. By taking advantage of the liquid-like polymeric matrices as a separation medium and the empty cavities as gas transport pathway, this unique porous liquid can function as a promising candidate for gas separation. Moreover, such a facile synthetic strategy can be further extended to the fabrication of other types of nanostructure-based porous liquid, opening up new opportunities for preparation of porous liquids with attractive properties for specific tasks.

  5. Slit/Robo pathway: a promising therapeutic target for cancer.

    Science.gov (United States)

    Gara, Rishi K; Kumari, Sonam; Ganju, Aditya; Yallapu, Murali M; Jaggi, Meena; Chauhan, Subhash C

    2015-01-01

    Axon guidance molecules, slit glycoprotein (Slit) and Roundabout receptor (Robo), have implications in the regulation of physiological processes. Recent studies indicate that Slit and Robo also have important roles in tumorigenesis, cancer progression and metastasis. The Slit/Robo pathway can be considered a master regulator for multiple oncogenic signaling pathways. Herein, we provide a comprehensive review on the role of these molecules and their associated signaling pathways in cancer progression and metastasis. Overall, the current available data suggest that the Slit/Robo pathway could be a promising target for development of anticancer drugs.

  6. Promises and challenges of anticancer drugs that target the epigenome.

    Science.gov (United States)

    Verbrugge, Inge; Johnstone, Ricky W; Bots, Michael

    2011-10-01

    The occurrence of epigenetic aberrations in cancer and their role in promoting tumorigenesis has led to the development of various small molecule inhibitors that target epigenetic enzymes. In preclinical settings, many epigenetic inhibitors demonstrate promising activity against a variety of both hematological and solid tumors. The therapeutic efficacy of those inhibitors that have entered the clinic however, is restricted predominantly to hematological malignancies. Here we outline the observed epigenetic aberrations in various types of cancer and the clinical responses to epigenetic drugs. We furthermore discuss strategies to improve the responsiveness of both hematological and solid malignancies to epigenetic drugs.

  7. PROMISES FOR TREATING COLON CANCER PATIENTS WITH BRAF GENE MUTATION

    Directory of Open Access Journals (Sweden)

    M. Yu. Fedyanin

    2014-01-01

    Full Text Available Colon cancer represents a heterogenous disease group, which differ by cancerogenesis mechanisms, molecular alterations, prognosis and treatment possibilities. In modern clinical practice assessment of KRAS and NRAS genes status is already necessary in order to prescribe anti-EGFR treatment for metastatic disease. A separate poor prognosis group are patients with BRAF mutation. In this review we will focus on biological features of BRAF-mutant colorectal cancer, its epidemiology, clinical features on different stages, treatment choice and promising new treatment possibilities.

  8. Pericytes: developmental, physiological, and pathological perspectives, problems, and promises.

    Science.gov (United States)

    Armulik, Annika; Genové, Guillem; Betsholtz, Christer

    2011-08-16

    Pericytes, the mural cells of blood microvessels, have recently come into focus as regulators of vascular morphogenesis and function during development, cardiovascular homeostasis, and disease. Pericytes are implicated in the development of diabetic retinopathy and tissue fibrosis, and they are potential stromal targets for cancer therapy. Some pericytes are probably mesenchymal stem or progenitor cells, which give rise to adipocytes, cartilage, bone, and muscle. However, there is still confusion about the identity, ontogeny, and progeny of pericytes. Here, we review the history of these investigations, indicate emerging concepts, and point out problems and promise in the field of pericyte biology. Copyright © 2011 Elsevier Inc. All rights reserved.

  9. Challenges and promises for translating computational tools into clinical practice.

    Science.gov (United States)

    Ahn, Woo-Young; Busemeyer, Jerome R

    2016-10-01

    Computational modeling and associated methods have greatly advanced our understanding of cognition and neurobiology underlying complex behaviors and psychiatric conditions. Yet, no computational methods have been successfully translated into clinical settings. This review discusses three major methodological and practical challenges (A. precise characterization of latent neurocognitive processes, B. developing optimal assays, C. developing large-scale longitudinal studies and generating predictions from multi-modal data) and potential promises and tools that have been developed in various fields including mathematical psychology, computational neuroscience, computer science, and statistics. We conclude by highlighting a strong need to communicate and collaborate across multiple disciplines.

  10. eHealth Applications Promising Strategies for Behavior Change

    CERN Document Server

    Noar, Seth M

    2012-01-01

    eHealth Applications: Promising Strategies for Behavior Change provides an overview of technological applications in contemporary health communication research, exploring the history and current uses of eHealth applications in disease prevention and management. This volume focuses on the use of these technology-based interventions for public health promotion and explores the rapid growth of an innovative interdisciplinary field. The chapters in this work discuss key eHealth applications by presenting research examining a variety of technology-based applications. Authors Seth M. Noar and Nancy

  11. Dimeric Surfactants: Promising Ingredients of Cosmetics and Toiletries

    Directory of Open Access Journals (Sweden)

    Naveen Kumar

    2013-11-01

    Full Text Available Surfactants are an essential ingredient for cosmetic, toiletries and personal care products for enhancing their performance. Dimeric surfactants demonstrate superiority compared to conventional surfactants in all areas of application. Dimeric surfactants are extremely promising for utilization in various cosmetic formulations viz. shampoo, lotions, creams, conditioners etc. These surfactants possess extremely unique surface properties viz. lower surface tension, unique micellization, low critical micelle concentration (CMC and antimicrobial activity, higher solubilization etc. Dimerics enhance the performances of cosmetics in an extraordinary manner and provide eco-friendly preparations for human epidermis.

  12. Hold fast!

    DEFF Research Database (Denmark)

    Pedersen, Michael Svendsen

    Publikationen indeholder en kort præsentation af resultaterne fra en række initiativer for tosprogede og praktisk orienterede elever i erhvervsuddannelserne med henblik på at fastholde dem i uddannelse....

  13. Optimization Techniques for Source Follower Based Track-and-Hold Circuit for High Speed Wireless Communication

    Directory of Open Access Journals (Sweden)

    Manoj Kumar

    2011-03-01

    Full Text Available Since the current demand for high need for track and hold amplifiers (T&H operating at RF frequencies. A circuit is the key element in any modern wide band data acquisition system. Applications like a cable or a broad variety of different radio standards require high processing speeds with high resolution. The track-and-hold (T&H circuit is a fundamental block for analog allows most dynamic errors of A/D converters to be reduced, especially those showing up when using high frequency input signals. Having a wide band and precise acquisition system today’s trend towards multi-standard flexible radios, with as much signal processing as possible in digital domain. This work investigates effect of various design schemes and circuit topology for track and-hold circuit to achieve acceptable linearly, high slew rate, low power consumption and low noise

  14. Optimization Techniques for Source Follower Based Track-and-Hold Circuit for High Speed Wireless Communication

    Directory of Open Access Journals (Sweden)

    Manoj Kumar

    2011-03-01

    Full Text Available Since the current demand for highneedfor track and hold amplifiers (T&H operating at RF frequencies. Acircuit is the key element in any modern wideband data acquisition system. Applications like a cableor a broad variety of different radio standards require high processing speeds with high resolution. Thetrack-and-hold (T&H circuit is a fundamental block for analogallows most dynamic errors of A/D converters to be reduced, especially those showing up when usinghigh frequency input signals. Having a wideband and precise acquisition systemtoday’s trend towards multi-standard flexible radios, with as much signal processing as possible indigital domain. This work investigates effect of various design schemes and circuit topology for trackand-hold circuit to achieve acceptable linearly, high slew rate, low power consumption and low noise

  15. ORGANIZATION AND RESULTS OF AGRICULTURAL HOLDINGS REALIZING INVESTMENTS SUBSIDIZED WITH PUBLIC FUNDS

    Directory of Open Access Journals (Sweden)

    Zofia Kołoszko-Chomentowska

    2016-03-01

    Full Text Available In the present article, an attempt was made to assess the organization of production and economic results of agricultural holdings that realized investments subsidized with public funds, from the perspective of good agricultural practice. Agricultural holdings in the Podlaskie voivodeship registered in the FADN system in 2011–2012 were investigated. Assessment accounted for crop structure, stock density, production intensity, the value and structure of capital, and profi tableness of land, capital, and labour. Analysis showed that holdings benefi ting from subsidization of investments with public funds were characterized by greater production intensity and also achieved better economic results. However, they exerted greater pressure on the environment and posed hazards that mainly resulted from high stock density.  

  16. Magnetic Resonance Imaging in Breath-Hold Divers with Cerebral Decompression Sickness

    Directory of Open Access Journals (Sweden)

    Ryu Matsuo

    2014-01-01

    Full Text Available The mechanism of cerebral decompression sickness (DCS is still unclear. We report 2 cases of breath-hold divers with cerebral DCS in whom magnetic resonance imaging (MRI demonstrated distinctive characteristics. One case presented right hemiparesthesia, diplopia, and gait disturbance after breath-hold diving into the sea at a depth of 20 m. Brain MRI with fluid-attenuated inversion recovery (FLAIR sequence revealed multiple hyperintense lesions in the right frontal lobe, bilateral thalamus, pons, and right cerebellar hemisphere. The second case presented visual and gait disturbance after repetitive breath-hold diving into the sea. FLAIR imaging showed hyperintense areas in the bilateral occipito-parietal lobes. In both cases, diffusion-weighted imaging and apparent diffusion coefficient mapping revealed hyperintense areas in the lesions identified by FLAIR. Moreover, follow-up MRI showed attenuation of the FLAIR signal abnormalities. These findings are suggestive of transient hyperpermeability in the microvasculature as a possible cause of cerebral DCS.

  17. Emerging Cancer Vaccines: The Promise of Genetic Vectors

    Directory of Open Access Journals (Sweden)

    Gennaro Ciliberto

    2011-09-01

    Full Text Available Therapeutic vaccination against cancer is an important approach which, when combined with other therapies, can improve long-term control of cancer. In fact, the induction of adaptive immune responses against Tumor Associated Antigens (TAAs as well as innate immunity are important factors for tumor stabilization/eradication. A variety of immunization technologies have been explored in last decades and are currently under active evaluation, such as cell-based, protein, peptide and heat-shock protein-based cancer vaccines. Genetic vaccines are emerging as promising methodologies to elicit immune responses against a wide variety of antigens, including TAAs. Amongst these, Adenovirus (Ad-based vectors show excellent immunogenicity profile and have achieved immunological proof of concept in humans. In vivo electroporation of plasmid DNA (DNA-EP is also a desirable vaccine technology for cancer vaccines, as it is repeatable several times, a parameter required for the long-term maintenance of anti-tumor immunity. Recent findings show that combinations of different modalities of immunization (heterologous prime/boost are able to induce superior immune reactions as compared to single-modality vaccines. In this review, we will discuss the challenges and requirements of emerging cancer vaccines, particularly focusing on the genetic cancer vaccines currently under active development and the promise shown by Ad and DNA-EP heterologous prime-boost.

  18. Problems, challenges and promises: perspectives on precision medicine.

    Science.gov (United States)

    Duffy, David J

    2016-05-01

    The 'precision medicine (systems medicine)' concept promises to achieve a shift to future healthcare systems with a more proactive and predictive approach to medicine, where the emphasis is on disease prevention rather than the treatment of symptoms. The individualization of treatment for each patient will be at the centre of this approach, with all of a patient's medical data being computationally integrated and accessible. Precision medicine is being rapidly embraced by biomedical researchers, pioneering clinicians and scientific funding programmes in both the European Union (EU) and USA. Precision medicine is a key component of both Horizon 2020 (the EU Framework Programme for Research and Innovation) and the White House's Precision Medicine Initiative. Precision medicine promises to revolutionize patient care and treatment decisions. However, the participants in precision medicine are faced with a considerable central challenge. Greater volumes of data from a wider variety of sources are being generated and analysed than ever before; yet, this heterogeneous information must be integrated and incorporated into personalized predictive models, the output of which must be intelligible to non-computationally trained clinicians. Drawing primarily from the field of 'oncology', this article will introduce key concepts and challenges of precision medicine and some of the approaches currently being implemented to overcome these challenges. Finally, this article also covers the criticisms of precision medicine overpromising on its potential to transform patient care.

  19. Implicit processes in health psychology: Diversity and promise.

    Science.gov (United States)

    Sheeran, Paschal; Bosch, Jos A; Crombez, Geert; Hall, Peter A; Harris, Jennifer L; Papies, Esther K; Wiers, Reinout W

    2016-08-01

    Implicit processes refer to cognitive, affective, and motivational processes that influence health decisions and behavior without the person intending that influence. This special issue aims to increase appreciation of the diverse and promising research on implicit processes in health psychology, and to promote discussion about how this research improves understanding of health behavior change and can be harnessed to meet public health mandates. The articles included in the special issue showcase this diversity and promise, and present not only new findings, but also new theories, new measures, and state-of-the- art summaries of progress. The research demonstrates the added value of considering implicit processes for understanding health behaviors, their interactions with explicit processes and neural mechanisms, as well as the benefits of targeting implicit processes in health behavior interventions. At the same time, however, the papers in this special issue also point to potential boundary conditions, the importance of good measures and appropriate tests of implicit processes, and the challenges involved in assessing implicit processes' causal role in determining health behaviors. (PsycINFO Database Record

  20. Surface modification of promising cerium oxide nanoparticles for nanomedicine applications

    KAUST Repository

    Nanda, Himansu Sekhar

    2016-11-14

    Cerium oxide nanoparticles (CNPs) or nanoceria have emerged as a potential nanomedicine for the treatment of several diseases such as cancer. CNPs have a natural tendency to aggregate or agglomerate in their bare state, which leads to sedimentation in a biological environment. Since the natural biological environment is essentially aqueous, nanoparticle surface modification using suitable biocompatible hydrophilic chemical moieties is highly desirable to create effective aqueous dispersions. In this report, (6-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-hexyl)triethoxysilane was used as a functional, biocompatible organosilane to modify the surface of CNPs to produce promising nanoparticles which open substantial therapeutic avenues. The surface modified nanoparticles were produced in situ via an ammonia-induced ethylene glycol-assisted precipitation method and were characterized using complimentary characterization techniques. The interaction between the functional moiety and the nanoparticle was studied using powerful cross polarization/magic angle sample spinning solid state nuclear magnetic resonance spectroscopy. The surface-modified nanoparticles were extremely small and demonstrated a significant improvement in aqueous dispersibility. Moreover, the existence of a strong ionic coordination between the functional moiety and the surface of the nanoparticle was realised, indicating that the surface modified nanoceria are stable and that the nanoparticles should demonstrate an enhanced circulation time in a biological environment. The surface modification approach should be promising for the production of CNPs for nanomedicine applications. © The Royal Society of Chemistry.

  1. Analysis of pomological traits in new promising sweet cherry genotypes

    Directory of Open Access Journals (Sweden)

    Fotirić-Akšić Milica

    2013-01-01

    Full Text Available Sweet cherry breeding programs are interested in developing new cultivars that are very early or very late in ripening, high yielding, with excellent fruit size and quality. The aim of this study was to evaluate new, promising, sweet cherry genotypes (G-1 and G-2 for ripening time, fruit morphology and fruit chemical content, and compare it with the standard sweet cherry cultivars (Bigarreau Jaboulay, B. H. Burlat, Seneca, Hedelfiger Riesenkirsche, Germersdorfer Grosse Kirsche, Emperor Francis and Bing. Experiment was done during four consecutive years (2006-2009 in Grocka, near Belgrade. The earliest fruit ripening was recorded in G-2 (22nd April while the latest in `Bing` (2nd June. Fruit weight varied from 5.83 g (G-2 up to 8.93 g (G-1. Soluble solid content and total sugar content were the lowest in genotype G-2 (10.48%; 8.45%, respectively but the highest in Emperor Francis (18.28%; 15.98%, respectively. No matter the fact that some standard cultivars showed better results for some traits, genotypes G-1 and G-2 are considered very promising. So, genotype G-1 could be intended for table consumption since it ripens 2-3 days after cv. B. H. Burlat, but have much higher fruit weight. Also, genotype G-2, the earliest in this trial, showed satisfactory fruit weight for this ripening time, which makes it very interesting for fresh market production. [Projekat Ministarstva nauke Republike Srbije, br. 31063 i br. 31038

  2. Clinical life: expectation and the double edge of medical promise.

    Science.gov (United States)

    Shim, Janet K; Russ, Ann J; Kaufman, Sharon R

    2007-04-01

    This article introduces the concept of clinical life to capture a form of life produced in the pursuit and wake of medically achieved longevity. Relying on the retrospective accounts of 28 individuals over age 70 who have undergone cardiac bypass surgery, angioplasty or a stent procedure, as well as interviews with their families and with clinicians, we examine three features of clinical life. First, patients do not distinguish between clinical possibility and clinical promise, and thus assume that life can and will be improved by medical intervention in late life. Rather than anticipating a range of potential treatment outcomes, patients therefore expect the best-case scenario: that medical procedures will reverse aging, disease and the march of time. Second, patients then assess the value of their post-procedure lives in accordance with that expectation. Norms regarding what life 'should be like' at particular ages are continually recalibrated to the horizon of what is clinically possible. And third, the price of living longer entails a double-edged relationship with the clinic--it generates opportunities for bodily restoration and increased self-worth but also creates ambivalence about the value of life. This latter feature of clinical life is rarely publicly acknowledged in an environment that emphasizes medical promise.

  3. CHARACTERISTICS OF THE MOST PROMISING TOURIST REGIONS OF ABKHAZIA

    Directory of Open Access Journals (Sweden)

    Inar Murmanovich Kakaliya

    2015-01-01

    Full Text Available The article presents characteristics of the most promising tourist regions of Abkhazia. Along with the modernization of the existing tourist infrastructure, it is proposed to develop new trends in tourism – ecotourism, gastronomic, rural, ethnic, archeological, that are effective in the south-eastern region. It will increase tourist flow in Abkhazia. The southeast region of Abkhazia is sparsely populated due to the displacement of the entire infrastructure into the north-western part and it is promising for the development of such increasingly popular alternative types of tourism as extreme, ecological, birdwatching.It is advisable to develop a balneal mountain-climate resort Auadhar (as a representative project in this sector of the republic. The infrastructure of the balneological and mountain climatic resort is: resort polyclinic, balneary, drinking gallery, pump-room of the springs, numerous hotels, rest-houses and sanatoriums.The natural and climatic base in many aspects corresponds to, and in a number of objects even exceeds the world's largest resorts. The strengths of the Republic of Abkhazia are in its natural-touristic-recreational, agricultural, and resource potential. The Black Sea zone and the Colchis lowland areas are considered as the most favorable areas for crop development. Abkhazia has the potential to develop different types of tourism: traditional spa treatment, extreme tourism - caving and mountaineering. Compact location of many historical artifacts allows to combine different types of tourism and to see many places of interest within a short period of time.

  4. Emerging Cancer Vaccines: The Promise of Genetic Vectors

    Energy Technology Data Exchange (ETDEWEB)

    Aurisicchio, Luigi, E-mail: aurisicchio@takis-it.it [Takis, via di Castel Romano 100, 00128 Rome (Italy); BIOGEM scarl, via Camporeale, 83031 Ariano Irpino (AV) (Italy); Ciliberto, Gennaro [Takis, via di Castel Romano 100, 00128 Rome (Italy); Dipartimento di Medicina Sperimentale e Clinica, Università degli studi di Catanzaro “Magna Graecia”, 88100 Catanzaro (Italy)

    2011-09-22

    Therapeutic vaccination against cancer is an important approach which, when combined with other therapies, can improve long-term control of cancer. In fact, the induction of adaptive immune responses against Tumor Associated Antigens (TAAs) as well as innate immunity are important factors for tumor stabilization/eradication. A variety of immunization technologies have been explored in last decades and are currently under active evaluation, such as cell-based, protein, peptide and heat-shock protein-based cancer vaccines. Genetic vaccines are emerging as promising methodologies to elicit immune responses against a wide variety of antigens, including TAAs. Amongst these, Adenovirus (Ad)-based vectors show excellent immunogenicity profile and have achieved immunological proof of concept in humans. In vivo electroporation of plasmid DNA (DNA-EP) is also a desirable vaccine technology for cancer vaccines, as it is repeatable several times, a parameter required for the long-term maintenance of anti-tumor immunity. Recent findings show that combinations of different modalities of immunization (heterologous prime/boost) are able to induce superior immune reactions as compared to single-modality vaccines. In this review, we will discuss the challenges and requirements of emerging cancer vaccines, particularly focusing on the genetic cancer vaccines currently under active development and the promise shown by Ad and DNA-EP heterologous prime-boost.

  5. Effect of modified hold-relax stretching and static stretching on hamstring muscle flexibility.

    Science.gov (United States)

    Ahmed, Hashim; Iqbal, Amir; Anwer, Shahnawaz; Alghadir, Ahmad

    2015-02-01

    [Purpose] The aim of present study was to compare the effectiveness of modified hold-relax stretching and static stretching in improving the hamstring muscle flexibility. [Subjects and Methods] Forty-five male subjects with hamstring tightness were included in this study. The subjects were randomly placed into three groups: the modified hold-relax stretching, static stretching and control groups. The modified hold-relax stretching group performed 7 seconds of isometric contraction and then relaxed for 5 seconds, and this was repeated five times daily for five consecutive days. The static stretching group received 10 minutes of static stretching with the help of a pulley and weight system for five consecutive days. The control group received only moist heat for 20 minutes for five consecutive days. A baseline reading of passive knee extension (PKE) was taken prior to the intervention; rest measurements were taken immediate post intervention on day 1, day 3, day 5, and after a 1 week follow-up, i.e., at the 12th day. [Results] On comparing the baseline readings of passive knee extension (PKE), there was no difference noted between the three groups. On comparing the posttest readings on day 5 between the 3 groups, a significant difference was noted. However, post hoc analysis revealed an insignificant difference between the modified hold-relax stretching and static stretching groups. There was a significant difference between the static stretching and control groups and between the modified hold-relax stretching and control groups. [Conclusion] The results of this study indicate that both the modified hold-relax stretching technique and static stretching are equally effective, as there was no significant difference in improving the hamstring muscle flexibility between the two groups.

  6. ASYMMETRIC INFORMATION COST DAN HOLDING PERIODS SAHAM BIASA DI BURSA EFEK INDONESIA

    Directory of Open Access Journals (Sweden)

    Sulistyo Sulistyo

    2010-10-01

    Full Text Available The aim of this study is analyze variable s influencing holding period of common stock on public firm listed in LQ 45 index, that are firms generally have good performance assessed based on both marked performance and firm fundamental, then analyzing the dominance influencing variable. This study is conducted in Indonesian Stock Exchange with population of stock listed in LQ 45 index with the total of 64 firms. The samples taking method in purposive sampling with the criteria that the firms at least listed twice in LQ45 index on the study period. The analysis method used to analyze independend variable: spread, market value, variance return, and dividend pay out ratio and dependend variable: holding period is two stage least squares multiple regression model, since there is possibility that the correlation of bid-ask spread from the current periods and bid-ask spread and holding period and holding period from the previous period for every stock take place simultaneously. The result of study showed thar, partially, bid-ask spread variable that constitutes the different value between the highest price provided paid by buyer with the lowest price offered by seller has significance positive correlation on holding period of common stock and there is inverse correlation/significance negative between variance return variable that reflect the risk rate from stock effected by fluctuation     of stock price and holding period of common stock. While simultaneously, there is not significance correlation between dependent variable and independend variable that mean bid-ask spread, market value, variance return and dividend pay out ratio can’t describe variation from hoding period variable.

  7. The promise and pitfalls of the internet for cognitive behavioral therapy

    Directory of Open Access Journals (Sweden)

    Andersson Gerhard

    2010-12-01

    Full Text Available Abstract Internet-administered cognitive behavior therapy is a promising new way to deliver psychological treatment. There are an increasing number of controlled trials in various fields such as anxiety disorders, mood disorders and health conditions such as headache and insomnia. Among the advantages for the field of cognitive behavior therapy is the dissemination of the treatment, being able to access treatment from a distance, and possibilities to tailor the interventions. To date, studies in which large effects have been obtained have included patient support from a clinician. Recent trials suggest that this support may come from non-clinicians and that therapist effects are minimal. Since studies also suggest that internet-delivered cognitive behavior therapy can be equally effective as face-to-face cognitive behavior therapy, this is a finding that may have implications for CBT practitioners. However, there are other aspects to consider for implementation, as while clinicians may hold positive attitudes towards internet-delivered CBT a recent study suggested that patients are more skeptical and may prefer face-to-face treatment. In the present work, I argue that internet-delivered CBT may help to increase adherence to treatment protocols, that training can be facilitated by means of internet support, and that research on internet interventions can lead to new insights regarding what happens in regular CBT. Moreover, I conclude that internet-delivered CBT works best when support is provided, leaving an important role for clinicians who can incorporate internet treatment in their services. However, I also warn against disseminating internet-delivered CBT to patients for whom it is not suitable, and that clinical skills may suffer if clinicians are trained and practice mainly using the internet.

  8. Infrared detector Dewars - Increased LN2 hold time and vacuum jacket life spans

    Science.gov (United States)

    Jennings, D. E.; Boyd, W. J.; Blass, W. E.

    1976-01-01

    IR detector Dewars commonly suffer from shorter than desired LN2 hold times and insulation jacket vacuum corruption over relatively short time periods. In an attempt to solve this problem for a 9144 detector Dewar, small 1 liter/s appendage ion pumps were selected for continuous pumping of the vacuum jackets. This procedure extended LN2 hold times from 20 to 60 h and virtually eliminated vacuum jacket corruption. Thus the detector systems are usable continuously over periods of 6 months or more.

  9. Reducing appropriable quasi rents to combat the hold-up problem in contract agriculture

    DEFF Research Database (Denmark)

    Karantininis, Kostas; Graversen, Jesper Tranbjerg

    2005-01-01

    This paper examines the problem of hold-up in the agri-food sector. Production contracts offered to future Danish Broiler producers give rise to specific investments and appropriable quasi rents. Farmers are vulnerable to opportunistic behaviour by poultry processors which materializes in lower......, when building the broiler house, to prepare a viable future change in production from broilers to pigs. This will increase the bargaining power to farmers and may result in higher producer prices. Based on the general model of the hold-up problem with co-specific investments (Koss & Eaton, 1997...

  10. Two Stage Fully Differential Sample and Hold Circuit Using .18µm Technology

    Directory of Open Access Journals (Sweden)

    Dharmendra Dongardiye

    2014-05-01

    Full Text Available This paper presents a well-established Fully Differential sample & hold circuitry, implemented in 180-nm CMOS technology. In this two stage method the first stage give us very high gain and second stage gives large voltage swing. The proposed opamp provides 149MHz unity-gain bandwidth , 78 degree phase margin and a differential peak to peak output swing more than 2.4v. using the improved fully differential two stage operational amplifier of 76.7dB gain. Although the sample and hold circuit meets the requirements of SNR specifications.

  11. Influence of the section size and holding time on the graphite parameters of ductile iron production

    Directory of Open Access Journals (Sweden)

    S. Bockus

    2009-01-01

    Full Text Available This work was conducted to establish the conditions required to produce a desirable structure of the castings of various section sizes. This investigation was focused on the study of the influence of cooling rate or section size and holding time on graphite parameters of the ductile iron. Plates having thickness between 3 and 50mm were cast in sand molds using the same melt. The present investigation has shown that the section size of ductile iron castings and holding time had strong effect on the graphite parameters of the castings.

  12. Effects of Piracetam on Pediatric Breath Holding Spells: A Randomized Double Blind Controlled Trial

    OpenAIRE

    2012-01-01

    How to cite this article:Abbaskhanian A, Ehteshami S, Sajjadi S, Rezai MS. Effects of Piracetam on Pediatric Breath Holding Spells: A Randomized Double Blind Controlled Trial. Iran J Child Neurol Autumn 2012; 6(4): 9-15. Abstarct:Objective Breath holding spells (BHS) are common paroxysmal non-epileptic eventsin the pediatric population which are very stressfull despite their harmlessnature. There has been no specific treatment found for the spells yet. The aimof this study was to evaluate the...

  13. CAM operated tool for proximate or remote holding of an object

    Energy Technology Data Exchange (ETDEWEB)

    Schrum, P.B.; Gajdzik, G.P. Jr.

    1995-12-31

    A tool for releasably holding an object includes a receptacle having an outer sleeve and a rotatable inner sleeve. The inner sleeve is coaxially positioned within the outer sleeve and includes a locking member. An insert which is adapted to be operably associated with the receptacle includes a cam. The cam includes a guide and a slot so that when the cam is inserted into the inner sleeve, the guide aligns the locking member with the slot allowing the locking member to engage the slot thereby holding the receptacle and the insert together.

  14. A cryostat to hold frozen-spin polarized HD targets in CLAS: HDice-II

    Energy Technology Data Exchange (ETDEWEB)

    Lowry, M.M., E-mail: mlowry@jlab.org [Thomas Jefferson National Accelerator Facility, 12000 Jefferson Avenue, Newport News, VA 23606 (United States); Bass, C.D. [Thomas Jefferson National Accelerator Facility, 12000 Jefferson Avenue, Newport News, VA 23606 (United States); D' Angelo, A. [Thomas Jefferson National Accelerator Facility, 12000 Jefferson Avenue, Newport News, VA 23606 (United States); Universita' di Roma ‘Tor Vergata’, and INFN Sezione di Roma ‘Tor Vergata’, Via della Ricerca Scientifica, 1, I-00133 Roma (Italy); Deur, A.; Dezern, G. [Thomas Jefferson National Accelerator Facility, 12000 Jefferson Avenue, Newport News, VA 23606 (United States); Hanretty, C. [University of Virginia, 1400 University Avenue, Charlottesville, VA 22903 (United States); Ho, D. [Carnegie-Mellon University, 5000 Forbes Avenue, Pittsburgh, PA 15213 (United States); Kageya, T.; Kashy, D. [Thomas Jefferson National Accelerator Facility, 12000 Jefferson Avenue, Newport News, VA 23606 (United States); Khandaker, M. [Norfolk State University, 700 Park Avenue, Norfolk, VA 23504 (United States); Laine, V. [Thomas Jefferson National Accelerator Facility, 12000 Jefferson Avenue, Newport News, VA 23606 (United States); Université Blaise Pascal, 34 Avenue Carnot, 63000 Clermont-Ferrand (France); O' Connell, T. [University of Connecticut, 115 N Eagleville Road, Storrs-Mansfield, CT 06269 (United States); Pastor, O. [Thomas Jefferson National Accelerator Facility, 12000 Jefferson Avenue, Newport News, VA 23606 (United States); Peng, P. [University of Virginia, 1400 University Avenue, Charlottesville, VA 22903 (United States); Sandorfi, A.M. [Thomas Jefferson National Accelerator Facility, 12000 Jefferson Avenue, Newport News, VA 23606 (United States); Sokhan, D. [Institut de Physique Nucleaire, Bat 100 – M053, Orsay 91406 (France); and others

    2016-04-11

    The design, fabrication, operation, and performance of a {sup 3/4}He dilution refrigerator and superconducting magnet system for holding a frozen-spin polarized hydrogen deuteride target in the Jefferson Laboratory CLAS detector during photon beam running is reported. The device operates both vertically (for target loading) and horizontally (for target bombardment). The device proves capable of maintaining a base temperature of 50 mK and a holding field of 1 T for extended periods. These characteristics enabled multi-month polarization lifetimes for frozen spin HD targets having proton polarization of up to 50% and deuteron up to 27%.

  15. Performance and Risk of Macroeconomics Factors: Empirical evidence from Silver Ridge Holdings

    OpenAIRE

    Lourdes, Joan Salome

    2017-01-01

    The objective of this study is to examine the performance of Sliver Ridge Holdings Berhad as a whole with clearly defined risk factors and macroeconomic influence that contribute to its performance. The data is obtained from the yearly report of Silver Ridge Holdings Berhad from 2011-2015. Liquidity ratio and operating ratio measurement are used to view the performance of this company as a whole in a period of 5 years. In addition to it, the asset size measurement to the liquidity ratio has t...

  16. The Library Search Engine: A Smart Solution for Integrating Resources Beyond Library Holdings

    Directory of Open Access Journals (Sweden)

    Karin Herm

    2008-09-01

    Full Text Available The Cooperative Library Network Berlin-Brandenburg (KOBV, Germany addresses the problem of how to integrate resources found outside the library and library holdings into a single discovery tool. It presents a solution that uses open source technology to develop a next-generation catalog interface called the Library Search Engine. This pilot project was launched in 2007 with the library of Albert Einstein Science Park, Potsdam. The idea was to design and develop a fast and convenient search tool, integrating local holdings (books, journals, journal articles as well as relevant scientific subject information such as open access publications and bibliographies.

  17. Effects of Piracetam on Pediatric Breath Holding Spells: A Randomized Double Blind Controlled Trial

    Directory of Open Access Journals (Sweden)

    Ali ABBASKHANIAN

    2013-01-01

    Full Text Available How to cite this article:Abbaskhanian A, Ehteshami S, Sajjadi S, Rezai MS. Effects of Piracetam on Pediatric Breath Holding Spells: A Randomized Double Blind Controlled Trial. Iran J Child Neurol Autumn 2012; 6(4: 9-15. Abstarct:Objective Breath holding spells (BHS are common paroxysmal non-epileptic eventsin the pediatric population which are very stressfull despite their harmlessnature. There has been no specific treatment found for the spells yet. The aimof this study was to evaluate the efficacy of piracetam (2-oxo-l-pyrrolidineon these children.Materials & MethodsIn this randomized double blind clinical trial study, 150 children with severe BHS referred to our pediatric outpatient service were enrolled from August2011 to July 2012. The patients were randomized into two equal groups.One received 40mg/kg/day piracetam and the other group received placebo,twice daily. Patients were followed monthly for three months. The numberof attacks/month before and after treatment were documented.ResultsOf the enrolled patients, 86 were boys. The mean age of the patients was17 months (range, 6 to 24 months. In the piracetam group, 1 month after treatment an 81% response to treatment was found. In the placebo group,none of the patients had complete remission and 7% of the cases had partialremission. Overall, control of breath-holding spells was observed in 91%of the patients in the group taking piracetam as compared with 16% in the group taking placebo at the end of the study. There wasd nosignificant difference detected between the groups regarding the prevalenceof drug side effects.ConclusionA significant difference was detected between piracetam and placebo in prevention and controlling BHS. Piracetam (40mg/kg/day had a good effecton our patients. ReferencesDi Mario FJ Jr. Prospective study of children with cyanotic and pallid breath-holding spells. Pediatrics. 2001 Feb;107(2:265-9.Kotagal P, Costa M, Wyllie E, Wolgamuth B. Paroxysmal non epileptic

  18. Scrap tire recycling: Promising high value applications. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Bauman, B.D.; Leskovyansky, P.J.; Drela, H.

    1993-11-01

    Surface modification of scrap tire rubber (rubber particles treated with chlorine gas) show promise for ameliorating the scrap tire problem (the treated rubber can be used as a component in high- performance, expensive polymer systems). The process has been proven in Phase I. Phase II covers market/applications, process development (Forberg-design mixer reactor was chosen), plant design, capital cost estimate, economics environmental/safety/health, and energy impact. Almost of the small amount of chlorine is consumed. The capital costs for a rubber particle treatment facility are attractive, being at least two orders of magnitude less than that of facilities for making new polymer materials. Large volume markets using treated rubber are needed. The amount of scrap rubber available is small compared to the polymers available for replacement. 7 tabs, 16 figs.

  19. Social Science and Latin America: Promises to Keep

    Directory of Open Access Journals (Sweden)

    Roberto Briceño-León

    2015-08-01

    Full Text Available During his intellectual and academic life, Immanuel Wallerstein always makes contributions that are the subject of intense debate and controversy. Now he has given us, as an additional legacy to complete his four years of brilliant, hard, and—why not?—controversial work on behalf of our science as the President of the International Sociological Association (ISA, and as a contribution to commencing the 14th World Congress, another powerful provocation regarding the current state of the art of sociology, or better put, social science. He has done this with reference to the contributions sociological thinking has made, the challenges that social science has encountered, and the promises that social science should ful?ll. The provocation is broad and taken to its extreme.

  20. The Promise of the Anti-Idiotype Concept

    Directory of Open Access Journals (Sweden)

    Thomas eKieber-Emmons

    2012-12-01

    Full Text Available A basic tenet of antibody-based immunity is their specificity to antigenic determinates from foreign pathogen products to abnormal cellular components such as in cancer. However, an antibody has the potential to bind to more than one determinate, be it an antigen or another antibody. These observations led to the Idiotype Network Theory (INT to explain immune regulation, which has wax and waned in enthusiasm over the years. A truer measure of the impact of the INT is in terms of the ideas that are spawned that now form the mainstay of immunological research and whose roots is the promise of the Anti-Id concept. Among the applications of the INT is understanding the structural implications of the antibody mediated network that has the potential for innovation in terms of rational design of reagents with biological, chemical and pharmaceutical applications that underlies concepts of reverse immunology which is highlighted herein.

  1. Nanomedicine: Perspective and promises with ligand-directed molecular imaging

    Energy Technology Data Exchange (ETDEWEB)

    Pan Dipanjan [Department of Medicine, Washington University Medical School, St. Louis, MO (United States)], E-mail: dipanjan@wustl.edu; Lanza, Gregory M.; Wickline, Samuel A. [Department of Medicine, Washington University Medical School, St. Louis, MO (United States); Caruthers, Shelton D. [Department of Medicine, Washington University Medical School, St. Louis, MO (United States); Philips Healthcare, Andover, MA (United States)], E-mail: scaruthers@cmrl.wustl.edu

    2009-05-15

    Molecular imaging and targeted drug delivery play an important role toward personalized medicine, which is the future of patient management. Of late, nanoparticle-based molecular imaging has emerged as an interdisciplinary area, which shows promises to understand the components, processes, dynamics and therapies of a disease at a molecular level. The unprecedented potential of nanoplatforms for early detection, diagnosis and personalized treatment of diseases, have found application in every biomedical imaging modality. Biological and biophysical barriers are overcome by the integration of targeting ligands, imaging agents and therapeutics into the nanoplatform which allow for theranostic applications. In this article, we have discussed the opportunities and potential of targeted molecular imaging with various modalities putting a particular emphasis on perfluorocarbon nanoemulsion-based platform technology.

  2. The Promise of Neuroprotective Agents in Parkinson’s Disease

    Directory of Open Access Journals (Sweden)

    Judith ePotashkin

    2011-11-01

    Full Text Available Parkinson’s Disease is characterized by loss of dopamine neurons in the substantia nigra of the brain. Since there are limited treatment options for PD, neuroprotective agents are currently being tested as a means to slow disease progression. Agents targeting oxidative stress, mitochondrial dysfunction and inflammation are prime candidates for neuroprotection. This review identifies Rasagiline, Minocycline and creatine, as the most promising neuroprotective agents for PD, and they are all currently in phase III trials. Other agents possessing protective characteristics in delaying PD include stimulants, vitamins, supplements, and other drugs. Additionally, combination therapies also show benefits in slowing PD progression. The identification of neuroprotective agents for PD provides us with therapeutic opportunities for modifying the course of disease progression and, perhaps, reducing the risk of onset when preclinical biomarkers become available.

  3. Stem cells as promising therapeutic options for neurological disorders.

    Science.gov (United States)

    Yoo, Jongman; Kim, Han-Soo; Hwang, Dong-Youn

    2013-04-01

    Due to the limitations of pharmacological and other current therapeutic strategies, stem cell therapies have emerged as promising options for treating many incurable neurologic diseases. A variety of stem cells including pluripotent stem cells (i.e., embryonic stem cells and induced pluripotent stem cells) and multipotent adult stem cells (i.e., fetal brain tissue, neural stem cells, and mesenchymal stem cells from various sources) have been explored as therapeutic options for treating many neurologic diseases, and it is becoming obvious that each type of stem cell has pros and cons as a source for cell therapy. Wise selection of stem cells with regard to the nature and status of neurologic dysfunctions is required to achieve optimal therapeutic efficacy. To this aim, the stem cell-mediated therapeutic efforts on four major neurological diseases, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, and stroke, will be introduced, and current problems and future directions will be discussed.

  4. Salivaomics - A promising future in early diagnosis of dental diseases.

    Science.gov (United States)

    Koneru, Suneetha; Tanikonda, Rambabu

    2014-01-01

    Human saliva plays an important role in the health of the oral cavity and of the body as a whole. Salivary diagnostics is a dynamic and emerging field in the diagnosis of oral and systemic diseases. Saliva reflects the physiologic state of the body, including emotional, endocrinal, nutritional, and metabolic variations. The collection of saliva samples is noninvasive, safe, and inexpensive. Traditional clinical criteria are insufficient for determining sites of active disease, for monitoring the response to therapy, or for measuring the degree of susceptibility to future disease progression. Salivaomics includes five diagnostic alphabets proteins, mRNAs, miRNAs, metabolic compounds, and microbes offering substantial advantages because disease states may be accompanied by detectable changes. Salivaomics, the future of saliva-based techniques for early diagnosis of dental diseases, is promising and may offer a robust alternative for clinicians to use in the near future to make clinical decisions.

  5. Salivaomics - A promising future in early diagnosis of dental diseases

    Directory of Open Access Journals (Sweden)

    Suneetha Koneru

    2014-01-01

    Full Text Available Human saliva plays an important role in the health of the oral cavity and of the body as a whole. Salivary diagnostics is a dynamic and emerging field in the diagnosis of oral and systemic diseases. Saliva reflects the physiologic state of the body, including emotional, endocrinal, nutritional, and metabolic variations. The collection of saliva samples is noninvasive, safe, and inexpensive. Traditional clinical criteria are insufficient for determining sites of active disease, for monitoring the response to therapy, or for measuring the degree of susceptibility to future disease progression. Salivaomics includes five diagnostic alphabets proteins, mRNAs, miRNAs, metabolic compounds, and microbes offering substantial advantages because disease states may be accompanied by detectable changes. Salivaomics, the future of saliva-based techniques for early diagnosis of dental diseases, is promising and may offer a robust alternative for clinicians to use in the near future to make clinical decisions.

  6. Barium titanate nanoparticles: promising multitasking vectors in nanomedicine

    Science.gov (United States)

    Graziana Genchi, Giada; Marino, Attilio; Rocca, Antonella; Mattoli, Virgilio; Ciofani, Gianni

    2016-06-01

    Ceramic materials based on perovskite-like oxides have traditionally been the object of intense interest for their applicability in electrical and electronic devices. Due to its high dielectric constant and piezoelectric features, barium titanate (BaTiO3) is probably one of the most studied compounds of this family. Recently, an increasing number of studies have been focused on the exploitation of barium titanate nanoparticles (BTNPs) in the biomedical field, owing to the high biocompatibility of BTNPs and their peculiar non-linear optical properties that have encouraged their use as nanocarriers for drug delivery and as label-free imaging probes. In this review, we summarize all the recent findings about these ‘smart’ nanoparticles, including the latest, most promising potential as nanotransducers for cell stimulation.

  7. Angiogenesis Inhibition in Prostate Cancer: Current Uses and Future Promises

    Directory of Open Access Journals (Sweden)

    Jeanny B. Aragon-Ching

    2010-01-01

    Full Text Available Angiogenesis has been well recognized as a fundamental part of a multistep process in the evolution of cancer progression, invasion, and metastasis. Strategies for inhibiting angiogenesis have been one of the most robust fields of cancer investigation, focusing on the vascular endothelial growth factor (VEGF family and its receptors. There are numerous regulatory drug approvals to date for the use of these agents in treating a variety of solid tumors. While therapeutic efficacy has been established, challenges remain with regards to overcoming resistance and assessing response to antiangiogenic therapies. Prostate cancer is the most common noncutaneous malignancy among American men and angiogenesis plays a role in disease progression. The use of antiangiogenesis agents in prostate cancer has been promising and is hereby explored.

  8. Graphene - a promising material for organic photovoltaic cells.

    Science.gov (United States)

    Wan, Xiangjian; Long, Guankui; Huang, Lu; Chen, Yongsheng

    2011-12-01

    As a promising two-dimensional nanomaterial with outstanding electronic, optical, thermal, and mechanical properties, graphene has been proposed for many applications. In this Progress Report we summarize and discuss comprehensively the advances made so far for applications of graphene in organic photovoltaic (OPV) cells, including that for transparent electrodes, active layers and interfaces layer in OPV. It is concluded that graphene may very likely play a major role in new developments/improvements in OPVs. The future studies for this area are proposed to focus on the following: i) improving the conductivity without comprising the transparency as a transparent electrode material; ii) controlling the sheet sizes, band structure and surface morphology for use as a electron acceptor material, and iii) controlling and improving the functionalization and compatibility with other materials as interface layer material.

  9. Engineered T cells: the promise and challenges of cancer immunotherapy.

    Science.gov (United States)

    Fesnak, Andrew D; June, Carl H; Levine, Bruce L

    2016-08-23

    The immune system evolved to distinguish non-self from self to protect the organism. As cancer is derived from our own cells, immune responses to dysregulated cell growth present a unique challenge. This is compounded by mechanisms of immune evasion and immunosuppression that develop in the tumour microenvironment. The modern genetic toolbox enables the adoptive transfer of engineered T cells to create enhanced anticancer immune functions where natural cancer-specific immune responses have failed. Genetically engineered T cells, so-called 'living drugs', represent a new paradigm in anticancer therapy. Recent clinical trials using T cells engineered to express chimeric antigen receptors (CARs) or engineered T cell receptors (TCRs) have produced stunning results in patients with relapsed or refractory haematological malignancies. In this Review we describe some of the most recent and promising advances in engineered T cell therapy with a particular emphasis on what the next generation of T cell therapy is likely to entail.

  10. Gene therapy for gastric cancer: Is it promising?

    Institute of Scientific and Technical Information of China (English)

    Andreas P Sutter; Henry Fechner

    2006-01-01

    Gastric cancer is one of the most common tumors worldwide. The therapeutic outcome of conventional therapies is inefficient. Thus, new therapeutic strategies are urgently needed. Gene therapy is a promising molecular alternative in the treatment of gastric cancer,including the replacement of defective tumor suppressor genes, the inactivation of oncogenes, the introduction of suicide genes, genetic immunotherapy, anti-angiogenetic gene therapy, and virotherapy. Improved molecular biological techniques and a better understanding of gastric carcinogenesis have allowed us to validate a variety of genes as molecular targets for gene therapy.This review provides an update of the new developments in cancer gene therapy, new principles, techniques,strategies and vector systems, and shows how they may be applied in the treatment of gastric cancer.

  11. Programmed death-1 & its ligands: promising targets for cancer immunotherapy.

    Science.gov (United States)

    Shrimali, Rajeev K; Janik, John E; Abu-Eid, Rasha; Mkrtichyan, Mikayel; Khleif, Samir N

    2015-01-01

    Novel strategies for cancer treatment involving blockade of immune inhibitors have shown significant progress toward understanding the molecular mechanism of tumor immune evasion. The preclinical findings and clinical responses associated with programmed death-1 (PD-1) and PD-ligand pathway blockade seem promising, making these targets highly sought for cancer immunotherapy. In fact, the anti-PD-1 antibodies, pembrolizumab and nivolumab, were recently approved by the US FDA for the treatment of unresectable and metastatic melanoma resistant to anticytotoxic T-lymphocyte antigen-4 antibody (ipilimumab) and BRAF inhibitor. Here, we discuss strategies of combining PD-1/PD-ligand interaction inhibitors with other immune checkpoint modulators and standard-of-care therapy to break immune tolerance and induce a potent antitumor activity, which is currently a research area of key scientific pursuit.

  12. Self-acquired patient images: the promises and the pitfalls.

    Science.gov (United States)

    Damanpour, Shadi; Srivastava, Divya; Nijhawan, Rajiv I

    2016-03-01

    Self-acquired patient images, also known as selfies, are increasingly utilized in the practice of dermatology; however, research on their utility is somewhat limited. While the implementation of selfies has yet to be universally accepted, their role in triage appears to be especially useful. The potential for reducing office wait times, expediting referrals, and providing dermatologic services to patients with limited access to care is promising. In addition, as technology advances, the number of smartphone applications related to dermatology that are available to the general public has risen exponentially. With appropriate standardization, regulation, and confidentiality measures, these tools can be feasible adjuncts in clinical practice, dermatologic surgery, and teledermatology. Selfies likely will have a large role in dermatologic practice and delivery in the future.

  13. Wikipedia, sociology, and the promise and pitfalls of Big Data

    Directory of Open Access Journals (Sweden)

    Julia Adams

    2015-12-01

    Full Text Available Wikipedia is an important instance of “Big Data,” both because it shapes people's frames of reference and because it is a window into the construction—including via crowd-sourcing—of new bodies of knowledge. Based on our own research as well as others' critical and ethnographic work, we take as an instance Wikipedia's evolving representation of the field of sociology and sociologists, including such gendered aspects as male and female scholars and topics associated with masculinity and femininity. Both the gender-specific dynamics surrounding what counts as “notability” on the online encyclopedia and Wikipedia's relative categorical incoherence are discussed. If “Big Data” can be said to construct its own object, it is, in this instance, a curious and lop-sided one, exemplifying pitfalls as well as promise with respect to more accurate and democratic forms of knowledge.

  14. Reimagining Field Education in Social Work: The Promise Unveiled

    Directory of Open Access Journals (Sweden)

    Purnima George

    2013-11-01

    Full Text Available The current wave of neo-liberalism in Canada has driven our universities to retreat from their responsibilities as public institutions, accountable to their communities. In this paper we present a case study of field education in Canada and discuss the implications of the neoliberal academy on social work field education. On the basis of our experience as faculty consultants of BSW and MSW students, and coming from a school of social work that embraces an anti-oppression perspective as its guiding philosophy, we undertake a reconceptualization exercise in which we re-imagine field education. We politicize field education as a site with transformative possibilities. We describe the principles and processes that inform our reconceptualization and offer an example of how this might be realized in practice. This paper contributes towards developing new knowledge that unveils the promise of transformative change through a re-imagination of field education.

  15. Targeting aerobic glycolysis: 3-bromopyruvate as a promising anticancer drug.

    Science.gov (United States)

    Cardaci, Simone; Desideri, Enrico; Ciriolo, Maria Rosa

    2012-02-01

    The Warburg effect refers to the phenomenon whereby cancer cells avidly take up glucose and produce lactic acid under aerobic conditions. Although the molecular mechanisms underlying tumor reliance on glycolysis remains not completely clear, its inhibition opens feasible therapeutic windows for cancer treatment. Indeed, several small molecules have emerged by combinatorial studies exhibiting promising anticancer activity both in vitro and in vivo, as a single agent or in combination with other therapeutic modalities. Therefore, besides reviewing the alterations of glycolysis that occur with malignant transformation, this manuscript aims at recapitulating the most effective pharmacological therapeutics of its targeting. In particular, we describe the principal mechanisms of action and the main targets of 3-bromopyruvate, an alkylating agent with impressive antitumor effects in several models of animal tumors. Moreover, we discuss the chemo-potentiating strategies that would make unparalleled the putative therapeutic efficacy of its use in clinical settings.

  16. Adaptation finance: How can Durban deliver on past promises?

    Energy Technology Data Exchange (ETDEWEB)

    Ciplet, David; Roperts, J. Timmons; He, Linlang; Fields, Spencer [Brown University (United States); Khan, Mizan [North South University (Bangladesh)

    2011-11-15

    There is an ever-widening chasm between the support developing countries need to adapt to climate change, and the funding promised and delivered by wealthy nations. While UN climate meetings endlessly debate terms such as 'new and additional' or 'balanced allocation', even some basic commitments to adaptation funding are going unfulfilled. And as we approach the final year of the 'fast-start' phase for climate finance, there is no plan for the crucial 'scale-up' period of 2013–2019, when contributions must swell tenfold. At the Durban negotiations, countries should take three steps to ensure the developed world can meet its agreed responsibilities: establish funding sources based on international trade; define annual targets for the scale-up; and adopt a transparent, centralised accounting system.

  17. The promise of the anti-idiotype concept

    Science.gov (United States)

    Kieber-Emmons, Thomas; Monzavi-Karbassi, Bejatohlah; Pashov, Anastas; Saha, Somdutta; Murali, Ramachandran; Kohler, Heinz

    2012-01-01

    A basic tenet of antibody-based immunity is their specificity to antigenic determinates from foreign pathogen products to abnormal cellular components such as in cancer. However, an antibody has the potential to bind to more than one determinate, be it an antigen or another antibody. These observations led to the idiotype network theory (INT) to explain immune regulation, which has wax and waned in enthusiasm over the years. A truer measure of the impact of the INT is in terms of the ideas that now form the mainstay of immunological research and whose roots are spawned from the promise of the anti-idiotype concept. Among the applications of the INT is understanding the structural implications of the antibody-mediated network that has the potential for innovation in terms of rational design of reagents with biological, chemical, and pharmaceutical applications that underlies concepts of reverse immunology which is highlighted herein. PMID:23267437

  18. The promise of sporting bodies in phenomenological thinking

    DEFF Research Database (Denmark)

    Ravn, Susanne; Høffding, Simon

    2016-01-01

    phenomenology to empirically investigate the domain of sport and exercise, phenomenologists employ empirical data to substantiate their claims concerning foundational conditions of our being-in-the-world. In this article, we suggest a way to enhance the collaboration between the two fields by pointing out......For decades, qualitative researchers have used phenomenological thinking to advance reflections on particular kinds of lifeworlds. As emphasised by Allen-Collinson phenomenology offers a continuing promise of ‘bringing the body back in’ to theories on sport and physical activity. Turning...... and giving examples of the resource of ‘the factual variation.’ Coined by Shaun Gallagher and developed from the Husserlian eidetic variation, the factual variation uses exceptional cases, normally from pathology, to shed new light on foundational phenomenological concepts. Drawing on our research of sports...

  19. Promises and Challenges of Smac Mimetics as Cancer Therapeutics.

    Science.gov (United States)

    Fulda, Simone

    2015-11-15

    Inhibitor of Apoptosis (IAP) proteins block programmed cell death and are expressed at high levels in various human cancers, thus making them attractive targets for cancer drug development. Second mitochondrial activator of caspases (Smac) mimetics are small-molecule inhibitors that mimic Smac, an endogenous antagonist of IAP proteins. Preclinical studies have shown that Smac mimetics can directly trigger cancer cell death or, even more importantly, sensitize tumor cells for various cytotoxic therapies, including conventional chemotherapy, radiotherapy, or novel agents. Currently, several Smac mimetics are under evaluation in early clinical trials as monotherapy or in rational combinations (i.e., GDC-0917/CUDC-427, LCL161, AT-406/Debio1143, HGS1029, and TL32711/birinapant). This review discusses the promise as well as some challenges at the translational interface of exploiting Smac mimetics as cancer therapeutics.

  20. Targeting cyclooxygenase-2 in hematological malignancies: rationale and promise.

    Science.gov (United States)

    Bernard, M P; Bancos, S; Sime, P J; Phipps, R P

    2008-01-01

    There is much interest in the potential use of Cox-2 selective inhibitors in combination with other cancer therapeutics. Malignancies of hematopoietic and non-hematopoietic origin often have increased expression of cyclooxygenase-2 (Cox-2), a key modulator of inflammation. For example, hematological malignancies such as chronic lymphocytic leukemia, chronic myeloid leukemia, Hodgkin's lymphoma, non-Hodgkin's lymphoma and multiple myeloma often highly express Cox-2, which correlates with poor patient prognosis. Expression of Cox-2 enhances survival and proliferation of malignant cells, while negatively influencing anti-tumor immunity. Hematological malignancies expressing elevated levels of Cox-2 potentially avoid immune responses by producing factors that enhance angiogenesis and metastasis. Cellular immune responses regulated by natural killer cells, cytotoxic T lymphocytes, and T regulatory cells are also influenced by Cox-2 expression. Therefore, Cox-2 selective inhibitors have promising therapeutic potential in patients suffering from certain hematological malignancies.