Implementing of multilateral environmental agreements: which economic instruments for the countries of the PSZ?; Mise en oeuvre des accords multilateraux sur l'environnement: quels instruments economiques pour les pays de la zsp?

Energy Technology Data Exchange (ETDEWEB)

NONE

2001-03-01

Several multilateral environmental agreements (MEAs) have been concluded since the Rio Earth Summit in 1992. Some of them have created economic instruments designed to arrest the rapid degradation of the planet environment. Until now and for a variety of reasons, the countries in the Priority Solidarity Zone (PSZ) have not been able to stand as very active partners in negotiating these instruments. This study seeks to respond to the question of whether the PSZ countries are in a position to derive benefit from these new instruments and what the potential impact of these instruments will be on their medium and long-term development. This question often has to be put in more basic terms: ''do the conditions required to apply these instruments exist in the PSZ countries?''.

Friction and Wear Behavior of Several Hard Materials

NARCIS (Netherlands)

Quercia Bianchi, G.; Grigorescu, I.C.; Di Rauso, C.; Contreras, H.; Gutierrez, D.

2001-01-01

Sliding friction, abrasion and erosion tests were performed on several materials: cemented carbides, partially stabilized zirconia (Mg–PSZ), electroless Ni–P coatings and SAE 4140 steel as reference material. Sliding friction test was carried out in a pin-on-disk system. A micro-abrasion test was

TS-1 and TS-2 transient overpower tests on FFTF fuel

International Nuclear Information System (INIS)

Pitner, A.L.; Ferrell, P.C.; Culley, G.E.; Weber, E.T.

1985-01-01

The TS-1 and TS-2 TREAT transient experiments subjected a low burnup (2 MWd/kg) and a medium burnup (58 MWd/kg), respectively, FFTF irradiated fuel pin to unprotected 5 cents/s overpower transient conditions. The fuel pin failure response was similar in the two tests, which demonstrated a large margin to failure (P/P 0 > 3) and a favorable upper level failure location. Thus, for these transient conditions, burnup effects on transient performance appeared to be minimal in the range tested. Pin disruption in the medium burnup TS-2 test was more severe due to the higher fission gas pressurization, but failure occurred at only a 5% lower power level than for the low burnup TS-1 fuel pin. Both tests exhibited axial extrusion of molten fuel to the region above the fuel column several seconds before pin failure, demonstrating a potentially beneficial inherent safety mechanism to delay failure and mitigate accident consequences

A Timoshenko Piezoelectric Beam Finite Element with Consistent Performance Irrespective of Geometric and Material Configurations

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Litesh N. Sulbhewar

Full Text Available Abstract The conventional Timoshenko piezoelectric beam finite elements based on First-order Shear Deformation Theory (FSDT do not maintain the accuracy and convergence consistently over the applicable range of material and geometric properties. In these elements, the inaccuracy arises due to the induced potential effects in the transverse direction and inefficiency arises due to the use of independently assumed linear polynomial interpolation of the field variables in the longitudinal direction. In this work, a novel FSDT-based piezoelectric beam finite element is proposed which is devoid of these deficiencies. A variational formulation with consistent through-thickness potential is developed. The governing equilibrium equations are used to derive the coupled field relations. These relations are used to develop a polynomial interpolation scheme which properly accommodates the bending-extension, bending-shear and induced potential couplings to produce accurate results in an efficient manner. It is noteworthy that this consistently accurate and efficient beam finite element uses the same nodal variables as of conventional FSDT formulations available in the literature. Comparison of numerical results proves the consistent accuracy and efficiency of the proposed formulation irrespective of geometric and material configurations, unlike the conventional formulations.

A hybrid GA-TS algorithm for open vehicle routing optimization of coal mines material

Energy Technology Data Exchange (ETDEWEB)

Yu, S.W.; Ding, C.; Zhu, K.J. [China University of Geoscience, Wuhan (China)

2011-08-15

In the open vehicle routing problem (OVRP), the objective is to minimize the number of vehicles and the total distance (or time) traveled. This study primarily focuses on solving an open vehicle routing problem (OVRP) by applying a novel hybrid genetic algorithm and the Tabu search (GA-TS), which combines the GA's parallel computing and global optimization with TS's Tabu search skill and fast local search. Firstly, the proposed algorithm uses natural number coding according to the customer demands and the captivity of the vehicle for globe optimization. Secondly, individuals of population do TS local search with a certain degree of probability, namely, do the local routing optimization of all customer sites belong to one vehicle. The mechanism not only improves the ability of global optimization, but also ensures the speed of operation. The algorithm was used in Zhengzhou Coal Mine and Power Supply Co., Ltd.'s transport vehicle routing optimization.

ChemTS: an efficient python library for de novo molecular generation

Science.gov (United States)

Yang, Xiufeng; Zhang, Jinzhe; Yoshizoe, Kazuki; Terayama, Kei; Tsuda, Koji

2017-12-01

Automatic design of organic materials requires black-box optimization in a vast chemical space. In conventional molecular design algorithms, a molecule is built as a combination of predetermined fragments. Recently, deep neural network models such as variational autoencoders and recurrent neural networks (RNNs) are shown to be effective in de novo design of molecules without any predetermined fragments. This paper presents a novel Python library ChemTS that explores the chemical space by combining Monte Carlo tree search and an RNN. In a benchmarking problem of optimizing the octanol-water partition coefficient and synthesizability, our algorithm showed superior efficiency in finding high-scoring molecules. ChemTS is available at https://github.com/tsudalab/ChemTS.

A Comparison of Tropical Storm (TS) and Non-TS Gust Factors for Assessing Peak Wind Probabilities at the Eastern Range

Science.gov (United States)

Merceret, Francis J.; Crawford, Winifred C.

2010-01-01

Peak wind speed is an important forecast element to ensure the safety of personnel and flight hardware at Kennedy Space Center (KSC) and the Cape Canaveral Air Force Station (CCAFS) in East-Central Florida. The 45th Weather Squadron (45 WS), the organization that issues forecasts for the KSC/CCAFS area, finds that peak winds are more difficult to forecast than mean winds. This difficulty motivated the 45 WS to request two independent studies. The first (Merceret 2009) was the development of a reliable model for gust factors (GF) relating the peak to the mean wind speed in tropical storms (TS). The second (Lambert et al. 2008) was a climatological study of non-TS cool season (October-April) mean and peak wind speeds by the Applied Meteorology Unit (AMU; Bauman et al. 2004) without the use of GF. Both studies presented their statistics as functions of mean wind speed and height. Most of the few comparisons of TS and non-TS GF in the literature suggest that non-TS GF at a given height and mean wind speed are smaller than the corresponding TS GF. The investigation reported here converted the non-TS peak wind statistics calculated by the AMU to the equivalent GF statistics and compared them with the previous TS GF results. The advantage of this effort over all previously reported studies of its kind is that the TS and non-TS data were taken from the same towers in the same locations. This eliminates differing surface attributes, including roughness length and thermal properties, as a major source of variance in the comparison. The goal of this study is two-fold: to determine the relationship between the non-TS and TS GF and their standard deviations (GFSD) and to determine if models similar to those developed for TS data in Merceret (2009) could be developed for the non-TS environment. The results are consistent with the literature, but include much more detailed, quantitative information on the nature of the relationship between TS and non-TS GF and GFSD as a function

Electrically conductive material

Science.gov (United States)

Singh, J.P.; Bosak, A.L.; McPheeters, C.C.; Dees, D.W.

1993-09-07

An electrically conductive material is described for use in solid oxide fuel cells, electrochemical sensors for combustion exhaust, and various other applications possesses increased fracture toughness over available materials, while affording the same electrical conductivity. One embodiment of the sintered electrically conductive material consists essentially of cubic ZrO[sub 2] as a matrix and 6-19 wt. % monoclinic ZrO[sub 2] formed from particles having an average size equal to or greater than about 0.23 microns. Another embodiment of the electrically conductive material consists essentially at cubic ZrO[sub 2] as a matrix and 10-30 wt. % partially stabilized zirconia (PSZ) formed from particles having an average size of approximately 3 microns. 8 figures.

Possibilities of using soil microarthropods, with emphasis on mites (Arachnida, Acari, Mesostigmata, in assessment of successional stages in a reclaimed coal mine dump (Pszów, S Poland

Directory of Open Access Journals (Sweden)

MADEJ GRAŻYNA

2014-06-01

Full Text Available The usefulness of 2 methods for biomonitoring of the effects of land rehabilitation were compared in Pszów (Upper Silesian Coal Basin, south of Poland. Thirty-one species of mesostigmatid mites were collected from 3 study plots representing different stages of restoration of the mine dump Wrzosy in Pszów and community structure of the mites was analysed. There was a general trend for mesostigmatid species richness, diversity, and density to increase with the development of vegetation. The dominant early successional mesostigmatid species was the phoretic Hypoapis claviger. During this study, 4616 specimens of soil microarthropods were extracted in total. They were classified according to the Biological Soil Quality Index (QBS. We tested the sensitivity and usefulness of this index for monitoring of soil quality and found its good relationship with successional stages in the reclaimed mine dump. Thus the QBS index seems to be an efficient index for monitoring the effects of restoration in mine dumps. It is a simpler, quicker, and cheaper bioindicator method than the earlier method based on community structure analysis of mesostigmatid mites.

TS/EL ELECTRICAL WORK REQUEST FORM

CERN Multimedia

TS Department

2008-01-01

To facilitate the processing of requests for minor electrical installation work to be carried out by the TS/EL group, a new procedure designed to improve contacts and exchange of information with customers has been set up. The procedure comprises a check to determine whether the TS/EL or the TS/FM group is responsible for the area where the electrical work is to be done. If the work is to be performed by the EL group, an on-line request form must be completed. The following steps must be completed: On a web browser, use the link http://ts-dep.web.cern.ch/ts-dep/groups/el/el.htm In the left-hand menu choose ‘Demande de Travaux Electriques’ Enter the building number to check which group to contact and click ‘FIND’ If the area is: Under FM’s responsibility:\tCall 77777 Under EL’s responsibility:\tClick the link to the work form, complete it and send it (click ‘ENVOYER’) IMPORTANT This form is for minor electrical installation requests only. Please call 72201 in t...

Assessment of TS-1, a thick cane mutant

International Nuclear Information System (INIS)

Shama Rao, H.K.

1979-01-01

A true breeding thick cane mutant TS-1, induced by radiations, was obtained in variety Co-419. TS-1 was found to be superior to Co-419 with respect to cane size, weight, yield and juice quality. The thick canes of TS-1 were found to be solid even at 14 months age and so also their ratoons. The tillering habit of TS-1 has a definite advantage over other varieties with respect to easy intercultural field operations. TS-1 is now being tested under various agroclimatic zones in Karnataka, Maharashtra and U.P. (auth.)

Electrical resistivity of ceramic-metal composite materials in the percolation region: application in crucibles for induction furnaces; Resistividade eletrica de materiais compositos do tipo ceramica-metal na regiao de percolacao: aplicacao em cadinhos para fornos de inducao

Energy Technology Data Exchange (ETDEWEB)

Sene, Frank Ferrer

1997-07-01

Ceramic composite materials were produced by mixing powders of Partially Stabilized (PSZ) with titanium, niobium or nickel, and cristobalite with titanium. Pellets were produced by uniaxially pressing the material followed by cold isostatic pressing and finally sintering at 1600 deg C for 1,5 hours in argon. The metal content was varied in the range of 0-40 volume percent (v/o). Electrical resistivity measurements were performed in the temperature range of 25 - 700 deg C. Samples containing metallic inclusions above 25 v/o show the predominance of electronic type conducting. For samples with metallic inclusion below 25 v/o, a typically ionic conduction behavior has been observed. PSZ-Ti and PSZ-Ni samples containing 25 v/o of metallic inclusions show an insulator - conductor transition in a given temperature range. Cristobalite samples containing 30 v/o of titanium show a conductor - insulator transition also in a specific temperature range. Tests performed in an induction furnace showed that samples containing metallic inclusions above 25 v/o had self-heated when exposed to electro magnetic fields in the range of radio frequency (r.f.) Crucibles of PSZ-Ti were made by slip casting followed by sintering at 1600 deg C for 1.5 hours in argon. These crucibles were exposed to electromagnetic fields in the r.f. range and the maximum temperature reached was 1350 deg C. Microstructure characterization was performed on those materials by X-ray diffraction, EDS, optical and scanning electron microscopy. (author)

A green surfactant-assisted synthesis of hierarchical TS-1 zeolites with excellent catalytic properties for oxidative desulfurization.

Science.gov (United States)

Du, Shuting; Li, Fen; Sun, Qiming; Wang, Ning; Jia, Mingjun; Yu, Jihong

2016-02-25

Hierarchical TS-1 zeolites with uniform intracrystalline mesopores have been successfully synthesized through the hydrothermal method by using the green and cheap surfactant Triton X-100 as the mesoporous template. The resultant materials exhibit remarkably enhanced catalytic activity in oxidative desulfurization reactions compared to the conventional TS-1 zeolite.

Transcutaneous Spinal Direct Current Stimulation (tsDCS

Directory of Open Access Journals (Sweden)

Filippo eCogiamanian

2012-07-01

Full Text Available In the past ten years renewed interest has centered on non-invasive transcutaneous weak direct currents applied over the scalp to modulate cortical excitability (brain polarization or transcranial direct current stimulation, tDCS. Extensive literature shows that tDCS induces marked changes in cortical excitability that outlast stimulation.Aiming at developing a new, non invasive, approach to spinal cord neuromodulation we assessed the after-effects of thoracic transcutaneous spinal DC stimulation (tsDCS on somatosensory potentials (SEPs evoked in healthy subjects by posterior tibial nerve (PTN stimulation. Our findings showed that thoracic anodal tsDCS depresses the cervico-medullary PTN-SEP component (P30 without eliciting adverse effects. tsDCS also modulates post-activation H-reflex dynamics. Later works further confirmed that transcutaneous electric fields modulate spinal cord function. Subsequent studies in our laboratory showed that tsDCS modulates the flexion reflex in the human lower limb. Besides influencing the laser evoked potentials, tsDCS increases pain tolerance in healthy subjects. Hence, though the underlying mechanisms remain speculative, tsDCS modulates activity in lemniscal, spinothalamic and segmental motor systems.Here we review currently available experimental evidence that non-invasive spinal cord stimulation influences spinal function in humans and argue that, by focally modulating spinal excitability, tsDCS could provide a novel therapeutic tool complementary to drugs and invasive spinal cord stimulation in managing various pathologic conditions, including pain.

AHP 40: NAMUYI TIBETAN pha⁵⁴ tsə⁵⁴ RITUALS AND ORAL CHANTS

Directory of Open Access Journals (Sweden)

Libu Lakhi (Li Jianfu

2016-02-01

Full Text Available sa54 da54 (b. 1939 is a Namuyi pha54 tsə54 - a traditional Namuyi religious practitioner/ specialist - who chants and conducts religious rituals. He lives and practices in Liangshan Yi Autonomous Prefecture, Sichuan Province, China. This article introduces pha54 tsə54 sa54 da54 and the many hours of his oral materials recorded by Libu Lakhi in 2009 that are archived at http://tinyurl.com/lgf3row. In addition, aspects of Namuyi religion are described, including terms of mountain deities, ill omens and taboos, the pha54 tsə54, sa54 da54, chants, and a personal account of a ritual done in Dashui Village, Minsheng Township, Xichang City, Sichuan Province in March 2013. An appendix, seven photographs, and a diagram provide additional detail.

Synthesis of mesoporous TS-1 using a hybrid SiO2–TiO2 xerogel for catalytic oxidative desulfurization

International Nuclear Information System (INIS)

Yang, Seung-Tae; Jeong, Kwang-Eun; Jeong, Soon-Yong; Ahn, Wha-Seung

2012-01-01

Graphical abstract: Display Omitted Highlights: ► Meso-TS-1 catalyst was synthesized using a SiO 2 –TiO 2 xerogel with an organosilane precursor. ► Hierarchical pore structure was confirmed by characterization of the materials. ► Catalytic activity was tested using oxidative desulfurization of the model sulfur compounds. ► Meso-TS-1 demonstrated significantly improved catalytic activity than TS-1. -- Abstract: Mesoporous TS-1 (M-TS-1) was synthesized using a hybrid SiO 2 –TiO 2 xerogel combined with an organosilane precursor. Prepared samples were characterized by XRD, UV–vis spectroscopy, SEM, and N 2 adsorption–desorption measurement. M-TS-1, prepared in 2 days, showed high crystallinity and the best textural properties among the samples. The N 2 adsorption–desorption isotherms of M-TS-1 exhibited a hysteresis loop at pressure higher than P/P 0 = 0.4, clearly indicating the existence of mesopores. M-TS-1 has significantly larger mesopore volume (0.48 cm 3 /g) than that of conventional TS-1 (0.07 cm 3 /g), and showed a narrow peak centered at ca. 6.3 nm. In the oxidative desulfurization reaction, M-TS-1 was more active than conventional TS-1 at the same Ti-loading; M-TS-1 produced a dibenzothiophene (DBT) conversion of 96%, whereas conventional TS-1 produced a final DBT conversion of 5.6% after a reaction time of 180 min. Oxidative desulfurization over TS-1 was influenced both by electron density and steric hindrance in the sulfur compounds tested.

Comparative genomic analysis reveals a novel mitochondrial isoform of human rTS protein and unusual phylogenetic distribution of the rTS gene

Directory of Open Access Journals (Sweden)

McGuire John J

2005-09-01

Full Text Available Abstract Background The rTS gene (ENOSF1, first identified in Homo sapiens as a gene complementary to the thymidylate synthase (TYMS mRNA, is known to encode two protein isoforms, rTSα and rTSβ. The rTSβ isoform appears to be an enzyme responsible for the synthesis of signaling molecules involved in the down-regulation of thymidylate synthase, but the exact cellular functions of rTS genes are largely unknown. Results Through comparative genomic sequence analysis, we predicted the existence of a novel protein isoform, rTS, which has a 27 residue longer N-terminus by virtue of utilizing an alternative start codon located upstream of the start codon in rTSβ. We observed that a similar extended N-terminus could be predicted in all rTS genes for which genomic sequences are available and the extended regions are conserved from bacteria to human. Therefore, we reasoned that the protein with the extended N-terminus might represent an ancestral form of the rTS protein. Sequence analysis strongly predicts a mitochondrial signal sequence in the extended N-terminal of human rTSγ, which is absent in rTSβ. We confirmed the existence of rTS in human mitochondria experimentally by demonstrating the presence of both rTSγ and rTSβ proteins in mitochondria isolated by subcellular fractionation. In addition, our comprehensive analysis of rTS orthologous sequences reveals an unusual phylogenetic distribution of this gene, which suggests the occurrence of one or more horizontal gene transfer events. Conclusion The presence of two rTS isoforms in mitochondria suggests that the rTS signaling pathway may be active within mitochondria. Our report also presents an example of identifying novel protein isoforms and for improving gene annotation through comparative genomic analysis.

Comparative genomic analysis reveals a novel mitochondrial isoform of human rTS protein and unusual phylogenetic distribution of the rTS gene

Science.gov (United States)

Liang, Ping; Nair, Jayakumar R; Song, Lei; McGuire, John J; Dolnick, Bruce J

2005-01-01

Background The rTS gene (ENOSF1), first identified in Homo sapiens as a gene complementary to the thymidylate synthase (TYMS) mRNA, is known to encode two protein isoforms, rTSα and rTSβ. The rTSβ isoform appears to be an enzyme responsible for the synthesis of signaling molecules involved in the down-regulation of thymidylate synthase, but the exact cellular functions of rTS genes are largely unknown. Results Through comparative genomic sequence analysis, we predicted the existence of a novel protein isoform, rTS, which has a 27 residue longer N-terminus by virtue of utilizing an alternative start codon located upstream of the start codon in rTSβ. We observed that a similar extended N-terminus could be predicted in all rTS genes for which genomic sequences are available and the extended regions are conserved from bacteria to human. Therefore, we reasoned that the protein with the extended N-terminus might represent an ancestral form of the rTS protein. Sequence analysis strongly predicts a mitochondrial signal sequence in the extended N-terminal of human rTSγ, which is absent in rTSβ. We confirmed the existence of rTS in human mitochondria experimentally by demonstrating the presence of both rTSγ and rTSβ proteins in mitochondria isolated by subcellular fractionation. In addition, our comprehensive analysis of rTS orthologous sequences reveals an unusual phylogenetic distribution of this gene, which suggests the occurrence of one or more horizontal gene transfer events. Conclusion The presence of two rTS isoforms in mitochondria suggests that the rTS signaling pathway may be active within mitochondria. Our report also presents an example of identifying novel protein isoforms and for improving gene annotation through comparative genomic analysis. PMID:16162288

Evaluation of fracture toughness for metal/ceramics composite materials by means of miniaturized specimen technique

International Nuclear Information System (INIS)

Saito, Masahiro; Takahashi, Hideaki; Jeong, Hee-Don; Kawasaki, Akira; Watanabe, Ryuzo

1991-01-01

In order to evaluate fracture strength for Y 2 O 3 -ZrO 2 , 3 mol% Y 2 O 3 -ZrO 2 (PSZ)/SUS 304 composite materials, Macor as a machinable ceramics and comercially available ceramics (SiC, Si 3 N 4 , PSZ, Al 2 O 3 ), fracture toughness tests were carried out by use of RCT or bending specimens. On the other hand, the fracture strength of these materials was evaluated and inspected the correlation between fracture toughness and fracture stress of small punch (SP) or modified small punch (MSP) test data to predict the fracture toughness value by using miniaturized specimens. Characteristic of the MSP testing method is the ability to evaluate elastic modulus (Young's modulus), fracture strength, yield strength, fracture strain, and fracture energy, etc., with high accuracy and good reproducibility for brittle materials. For a series of metal/ ceramics composites which from ductile to brittle, this paper clarified clear the applicable range for SP and MSP testing methods, which suggested that the simultaneous use of SP and MSP test methods can evaluate the fracture strength of metal/ ceramics composites. (author)

A non-chemically selective top-down approach towards the preparation of hierarchical TS-1 zeolites with improved oxidative desulfurization catalytic performance.

Science.gov (United States)

Du, Shuting; Chen, Xiaoxin; Sun, Qiming; Wang, Ning; Jia, Mingjun; Valtchev, Valentin; Yu, Jihong

2016-02-28

Hierarchical TS-1 zeolites with secondary macropores have been successfully prepared by using two different fluoride-containing chemical etching post-treated routes. Hierarchical TS-1 zeolites exhibited a chemical composition similar to that of the parent material and showed remarkably enhanced catalytic activity in oxidative desulfurization reaction.

Movable Thomson scattering system based on optical fiber (TS-probe)

International Nuclear Information System (INIS)

Narihara, K.; Hayashi, H.

2009-01-01

This paper proposes a movable compact Thomson scattering (TS) system based on optical fibers (TS-probe). A TS-probe consists of a probe head, optical fiber, a laser-diode, polychromators and lock-in amplifiers. A laser beam optics and light collection optics are mounted rigidly on a probe head with a fixed scattering position. Laser light and scattered light are transmitted by flexible optical fibers, enabling us to move the TS-prove head freely during plasma discharge. The light signal scattered from an amplitude-modulated laser is detected against the plasma light based on the principle of the lock-in amplifier. With a modulated laser power of 300W, the scattered signal from a sheet plasma of 15 mm depth and n e -10 19 m -3 will be measured with 10% accuracy by setting the integrating time to 0.1 s. The TS-probe head is like a 1/20 model of the currently operating LHD-TS. (author)

Synthesis of mesoporous TS-1 using a hybrid SiO{sub 2}–TiO{sub 2} xerogel for catalytic oxidative desulfurization

Energy Technology Data Exchange (ETDEWEB)

Yang, Seung-Tae [Department of Chemical Engineering, Inha University, Incheon 402-751 (Korea, Republic of); Jeong, Kwang-Eun; Jeong, Soon-Yong [Research Center for Green Catalysis, Division of Green Chemistry and Engineering Research, Korea Research Institute of Chemical Technology, P.O. Box 107, 141 Gajeong-ro, Yuseong, Daejeon 305-600 (Korea, Republic of); Ahn, Wha-Seung, E-mail: whasahn@inha.ac.kr [Department of Chemical Engineering, Inha University, Incheon 402-751 (Korea, Republic of)

2012-12-15

Graphical abstract: Display Omitted Highlights: ► Meso-TS-1 catalyst was synthesized using a SiO{sub 2}–TiO{sub 2} xerogel with an organosilane precursor. ► Hierarchical pore structure was confirmed by characterization of the materials. ► Catalytic activity was tested using oxidative desulfurization of the model sulfur compounds. ► Meso-TS-1 demonstrated significantly improved catalytic activity than TS-1. -- Abstract: Mesoporous TS-1 (M-TS-1) was synthesized using a hybrid SiO{sub 2}–TiO{sub 2} xerogel combined with an organosilane precursor. Prepared samples were characterized by XRD, UV–vis spectroscopy, SEM, and N{sub 2} adsorption–desorption measurement. M-TS-1, prepared in 2 days, showed high crystallinity and the best textural properties among the samples. The N{sub 2} adsorption–desorption isotherms of M-TS-1 exhibited a hysteresis loop at pressure higher than P/P{sub 0} = 0.4, clearly indicating the existence of mesopores. M-TS-1 has significantly larger mesopore volume (0.48 cm{sup 3}/g) than that of conventional TS-1 (0.07 cm{sup 3}/g), and showed a narrow peak centered at ca. 6.3 nm. In the oxidative desulfurization reaction, M-TS-1 was more active than conventional TS-1 at the same Ti-loading; M-TS-1 produced a dibenzothiophene (DBT) conversion of 96%, whereas conventional TS-1 produced a final DBT conversion of 5.6% after a reaction time of 180 min. Oxidative desulfurization over TS-1 was influenced both by electron density and steric hindrance in the sulfur compounds tested.

The TS 600: automatic control system for eddy currents

International Nuclear Information System (INIS)

Poulet, J.P.

1986-10-01

In the scope of fabrication and in service inspection of the PWR steam generator tubing bendle, FRAMATOME developed an automatic Eddy Current testing system: TS600. Based on a mini-computer, TS600 allows to digitize, to store and to process data in various ways, so it is possible to perform several kinds of inspection: conventional inservice inspection, roll area profilometry...... TS600 can also be used to develop new methods of examination [fr

Cell cycle phase dependent emergence of thymidylate synthase studied by monoclonal antibody (M-TS-4).

Science.gov (United States)

Shibui, S; Hoshino, T; Iwasaki, K; Nomura, K; Jastreboff, M M

1989-05-01

A method of identifying thymidylate synthase (TS) at the cellular level was developed using anti-TS monoclonal antibody (M-TS-4), a monoclonal antibody created against purified TS from a HeLa cell line. In HeLa cells and four human glioma cell lines (U-251, U-87, 343-MGA, and SF-188), TS was identified primarily in the cytoplasm. Autoradiographic and flow cytometric studies showed that TS appeared mainly in the G1 phase and subsided early in the S phase; thus, the G1 phase can be divided into TS-positive and -negative fractions. Nuclear TS was not demonstrated unequivocally with M-TS-4, and the relationship between nuclear TS and DNA synthesis could not be determined. Although the percentage of TS-positive cells was larger than the S-phase fraction measured by autoradiography after a pulse of tritiated thymidine or by the immunoperoxidase method using BUdR, the ratios were within a similar range (1.2-1.4) in all cell lines studied. Therefore, the S-phase fraction can be estimated indirectly from the percentage of TS-positive cells measured by M-TS-4. Because the emergence of TS detected by our method is cell cycle dependent, M-TS-4 may be useful for biochemical studies of TS and for cytokinetic analysis.

Solderability study of RABiTS-based YBCO coated conductors

International Nuclear Information System (INIS)

Zhang Yifei; Duckworth, Robert C.; Ha, Tam T.; Gouge, Michael J.

2011-01-01

Study examines the implication of solder and flux selection in YBCO splice joints. Focus is on commercially available RABiTS-based YBCO coated conductors. Solderability varied with solder and flux for three different stabilizations tested. Resistivity of stabilizer was dominant factor in splice joint resistance. Solder materials affected splice joint resistance when solderability was poor. The solderability of commercially available YBa 2 Cu 3 O 7-x (YBCO) coated conductors that were made from Rolling Assisted Biaxially Textured Substrates (RABiTS)-based templates was studied. The coated conductors, also known as second-generation (2G) high temperature superconductor (HTS) wires (in the geometry of flat tapes about 4 mm wide), were laminated with copper, brass, or stainless steel strips as stabilizers. To understand the factors that influence their solderability, surface profilometry and scanning electron microscopy were used to characterize the wire surfaces. The solderability of three solders, 52In48Sn, 67Bi33In, and 100In (wt.%), was evaluated using a standard test (IPC/ECA J-STD-002) and with two different commercial fluxes. It was found that the solderability varied with the solder and flux but the three different wires showed similar solderability for a fixed combination of solder and flux. Solder joints of the 2G wires were fabricated using the tools and the procedures recommended by the HTS wire manufacturer. The solder joints were made in a lap-joint geometry and with the superconducting sides of the two wires face-to-face. The electrical resistances of the solder joints were measured at 77 K, and the results were analyzed to qualify the soldering materials and evaluate the soldering process. It was concluded that although the selection of soldering materials affected the resistance of a solder joint, the resistivity of the stabilizer was the dominant factor.

Facile Synthesis of Yolk/Core-Shell Structured TS-1@Mesosilica Composites for Enhanced Hydroxylation of Phenol

KAUST Repository

Zou, Houbing

2015-12-14

© 2015 by the authors. In the current work, we developed a facile synthesis of yolk/core-shell structured TS-1@mesosilica composites and studied their catalytic performances in the hydroxylation of phenol with H2O2 as the oxidant. The core-shell TS-1@mesosilica composites were prepared via a uniform coating process, while the yolk-shell TS-1@mesosilica composite was prepared using a resorcinol-formaldehyde resin (RF) middle-layer as the sacrificial template. The obtained materials were characterized by X-ray diffraction (XRD), N2 sorption, Fourier transform infrared spectoscopy (FT-IR) UV-Visible spectroscopy, scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The characterization results showed that these samples possessed highly uniform yolk/core-shell structures, high surface area (560–700 m2 g−1) and hierarchical pore structures from oriented mesochannels to zeolite micropores. Importantly, owing to their unique structural properties, these composites exhibited enhanced activity, and also selectivity in the phenol hydroxylation reaction.

Tegafur/gimeracil/oteracil (TS-1 induced Stevens–Johnson syndrome: Case report

Directory of Open Access Journals (Sweden)

Satoko Minakawa

2013-09-01

Full Text Available TS-1 is an oral fluoropyrimidine anticancer drug that contains tegafur, gimeracil, and oteracil. A 78-year-old Japanese male who was diagnosed with carcinoma of the oral floor (rT4aN0M0 was prescribed a standard dose of TS-1 (80 mg/day. On Day 8 after administration of TS-1, an eruption developed. There was erythema, along with vesicles and erosions involving the lip, face, neck, trunk, limbs, and genitals. The drug-induced lymphocyte stimulation test (DLST for TS-1 was negative on the 23rd day, but positive on the 43rd day (20 days after discontinuing prednisolone. The condition was diagnosed as Stevens–Johnson syndrome due to TS-1 because of the clinical course and laboratory results. This case and 24 cases previously reported in the literature were analyzed. The types of drug eruption were drug-related lupus (9 cases, acral erythema (7 cases, scleroderma-like skin lesion (2 cases, Stevens–Johnson syndrome (2 cases, lichenoid eruption (1 case, purpura (1 case, lichen planus (1 case, erythema multiforme (1 case, hypopigmentation (1 case and toxic epidermal necrolysis (1 case, respectively. In view of the increasing usage of TS-1 in several common cancers, clinicians should be aware of drug eruptions due to TS-1.

[Construction of a system for proper TS-1 application].

Science.gov (United States)

Azuma, Sayaka; Morimoto, Shigefumi; Kagawa, Kunihiko; Katada, Yoshinori; Hasegawa, Kenji; Tabuse, Katsuyoshi

2010-03-01

TS-1 is an oral anti-tumor drug, which contains 5-chloro-2, 4-dihydroxypyridine (CDHP), a compound mainly excreted in urine. Since the CDHP concentration is increased among patients with impaired renal function, the frequency of side effects of TS-1 increases in such patients. Therefore, we constructed a computer-aided system that enables prompt monitoring of creatinine clearance (Ccr) calculated from the serum creatinine levels of patients prescribed TS-1 at the time pharmacists prepare the medicine. With this system, we found two cases who were prescribed TS-1, despite their decreased Ccr. One was a patient whose estimated Ccr was less than 30 mL/min/m2. With such renal malfunction, pharmacokinetics of the drug was considerably changed compared with normal control, and the dosage should be reduced. The other case presented with severe jaundice and had only a mild decrease of renal function (Ccr: 50 mL/min/m2). So we measured the concentration of uracil in the urine and performed a drug lymphocyte stimulation test for further investigation of concomitant affecting factors. Our system is useful because it can show pharmacists both the dosage TS-1 patients take and their renal function at a glance in real time. This system can be adapted for every medicine which might accumulate in patients with renal dysfunction.

Adrenalectomy for Cushing's syndrome: do's and don'ts.

Science.gov (United States)

Paduraru, D N; Nica, A; Carsote, M; Valea, A

2016-01-01

Aim. To present specific aspects of adrenalectomy for Cushing's syndrome (CS) by introducing well established aspects ("do's") and less known aspects ("don'ts"). Material and Method. This is a narrative review. Results. The "do's" for laparoscopic adrenalectomy (LA) are the following: it represents the "gold standard" for secretor and non-secretor adrenal tumors and the first line therapy for CS with an improvement of cardio-metabolic co-morbidities; the success rate depending on the adequate patients' selection and the surgeon's skills. The "don'ts" are large (>6-8 centimeters), locally invasive, malignant tumors requiring open adrenalectomy (OA). Robotic adrenalectomy is a new alternative for LA, with similar safety and conversion rate and lower pain drugs use. The "don'ts" are the following: lack of randomized controlled studies including oncologic outcome, different availability at surgical centers. Related to the sub-types of CS, the "do's" are the following: adrenal adenomas which are cured by LA, while adrenocortical carcinoma (ACC) requires adrenalectomy as first line therapy and adjuvant mitotane therapy; synchronous bilateral adrenalectomy (SBA) is useful for Cushing's disease (only cases refractory to pituitary targeted therapy), for ectopic Cushing's syndrome (cases with unknown or inoperable primary site), and for bilateral cortisol producing adenomas. The less established aspects are the following: criteria of skilled surgeon to approach ACC; the timing of surgery in subclinical CS; the need for adrenal vein catheterization (which is not available in many centers) to avoid unnecessary SBA. Conclusion. Adrenalectomy for CS is a dynamic domain; LA overstepped the former OA area. The future will improve the knowledge related to RA while the cutting edge is represented by a specific frame of intervention in SCS, children and pregnant women. Abbreviations: ACC = adrenocortical carcinoma, ACTH = Adrenocorticotropic Hormone, CD = Cushing's disease, CS

CATALYTIC PERFORMANCES OF Fe2O3/TS-1 CATALYST IN PHENOL HYDROXYLATION REACTION

Directory of Open Access Journals (Sweden)

Didik Prasetyoko

2010-07-01

Full Text Available Hydroxylation reaction of phenol into diphenol, such as hydroquinone and catechol, has a great role in many industrial applications. Phenol hydroxylation reaction can be carried out using Titanium Silicalite-1 (TS-1 as catalyst and H2O2 as an oxidant. TS-1 catalyst shows high activity and selectivity for phenol hydroxylation reaction. However, its hydrophobic sites lead to slow H2O2 adsorption toward the active site of TS-1. Consequently, the reaction rate of phenol hydroxylation reaction is tends to be low. Addition of metal oxide Fe2O3 enhanced hydrophilicity of TS-1 catalyst. Liquid phase catalytic phenol hydroxylation using hydrogen peroxide as oxidant was carried out over iron (III oxide-modified TS-1 catalyst (Fe2O3/TS-1, that were prepared by impregnation method using iron (III nitrate as precursor and characterized by X-ray diffraction, infrared spectroscopy, nitrogen adsorption, pyridine adsorption, and hydrophilicity techniques. Catalysts 1Fe2O3/TS-1 showed maximum catalytic activity of hydroquinone product. In this research, the increase of hydroquinone formation rate is due to the higher hydrophilicity of Fe2O3/TS-1 catalysts compare to the parent catalyst, TS-1.   Keywords: Fe2O3/TS-1, hydrophilic site, phenol hydroxylation

Ceļa servitūts

OpenAIRE

Livdāns, Dāvis

2016-01-01

Bakalaura darba tēma ir “Ceļa servitūts.” Bakalaura darba mērķis ir izpētīt ceļa servitūta nodibināšanas kārtību, iespējamās kļūdas, praksē nodibināto servitūtu problēmjautājumus un to risinājumus. Bakalaura darba tapšanas stadijā autors izmantoja zinātnisko literatūru, normatīvos aktus, kā arīi ar to tapšanu saistītos dokumentus un juridiskās prakses materiālus. Darbā ir apskatīti gan Civillikumā noteiktie servitūtu nodibināšanas pamati, gan citi iespējamie nodibināšanas pamati, pēc kā ir an...

Not in Traffic Surveillance (NiTS)

Data.gov (United States)

Department of Transportation — The Not-in-Traffic Surveillance (NiTS) system is a virtual data collection system designed to provide counts and details regarding fatalities and injuries that occur...

T.S. Eliot i nordisk efterkrigstidsdigtning

DEFF Research Database (Denmark)

Larsen, Peter Stein

2009-01-01

andet indkredses den særlige fascinationskraft ved Eliots æstetik, som den kommer til udtryk i The Waste Land (1922), nemlig at der er tale om en uhyre sofistikeret brug af montageformen. For det tredje peges der gennem et par digtlæsninger på, hvordan Eliots montage-æstetik kan følges i nordisk poesi......Hvad er årsagen til, at T.S. Eliot måske mere end nogen anden digter har haft indflydelse på nordiske digtere i det 20. århundrede? Dette vil blive undersøgt i tre tempi i denne artikel. For det første gives der et generelt rids af, hvor man finder T.S. Eliots aftryk i nordisk litteratur. For det...

Hybrid vehicle turbine engine technology support (HVTE-TS) project. 1995--1996 annual report

Energy Technology Data Exchange (ETDEWEB)

NONE

1996-12-31

This report presents a summary of technical work accomplished on the Hybrid Vehicle Turbine Engine--Technology Support (HVTE-TS) Project during calendar years 1995 and 1996. Work was performed under an initial National Aeronautics and Space Administration (NASA) contract DEN3-336. As of September 1996 the contract administration was transferred to the US Department of Energy (DoE) Chicago Operations Office, and renumbered as DE-AC02-96EE50553. The purpose of the HVTE-TS program is to develop gas turbine engine technology in support of DoE and automotive industry programs exploring the use of gas turbine generator sets in hybrid-electric automotive propulsion systems. The program focus is directed to the development of four key technologies to be applied to advanced turbogenerators for hybrid vehicles: Structural ceramic materials and processes; Low emissions combustion systems; Regenerators and seals systems; and Insulation systems and processes. 60 figs., 9 tabs.

Reconstitution of Qbeta RNA replicase from a covalently bonded elongation factor Tu-Ts complex

DEFF Research Database (Denmark)

Brown, S; Blumenthal, T

1976-01-01

of these polypeptides, protein synthesis elongation factors EF-Tu and EF-Ts, can be covalently crosslinked with dimethyl suberimidate to form a complex which lacks the ability to catalyze the known host functions catalyzed by the individual elongation factors. Using a previously developed reconstitution system we have...... examined the effects of crosslinking the EF-Tu-Ts complex on reconstituted replicase activity. Renaturation is significantly more efficient when exogenously added native EF-Tu-Ts is crosslinked than when it is not. Crosslinked EF-Tu-Ts can be purified from a crude crosslinked postribosomal supernatant...... by its ability to replace EF-Tu and EF-Ts in the renaturation of denatured Qbeta replicase. A sample of Qbeta replicase with crosslinked EF-Tu-Ts replacing the individual elongation factors was prepared. Although it lacked EF-Tu and EF-Ts activities, it could initiate transcription of both poly...

T-S Fuzzy Modelling and H∞ Attitude Control for Hypersonic Gliding Vehicles

Directory of Open Access Journals (Sweden)

Weidong Zhang

2017-01-01

Full Text Available This paper addresses the T-S fuzzy modelling and H∞ attitude control in three channels for hypersonic gliding vehicles (HGVs. First, the control-oriented affine nonlinear model has been established which is transformed from the reentry dynamics. Then, based on Taylor’s expansion approach and the fuzzy linearization approach, the homogeneous T-S local modelling technique for HGVs is proposed. Given the approximation accuracy and controller design complexity, appropriate fuzzy premise variables and operating points of interest are selected to construct the T-S homogeneous submodels. With so-called fuzzy blending, the original plant is transformed into the overall T-S fuzzy model with disturbance. By utilizing Lyapunov functional approach, a state feedback fuzzy controller has been designed based on relaxed linear matrix inequality (LMI conditions to stable the original plants with a prescribed H∞ performance of disturbance. Finally, numerical simulations are performed to demonstrate the effectiveness of the proposed H∞ T-S fuzzy controller for the original attitude dynamics; the superiority of the designed T-S fuzzy controller compared with other local controllers based on the constructed fuzzy model is shown as well.

LIDAR TS for ITER core plasma. Part II: simultaneous two wavelength LIDAR TS

Science.gov (United States)

Gowers, C.; Nielsen, P.; Salzmann, H.

2017-12-01

We have shown recently, and in more detail at this conference (Salzmann et al) that the LIDAR approach to ITER core TS measurements requires only two mirrors in the inaccessible port plug area of the machine. This leads to simplified and robust alignment, lower risk of mirror damage by plasma contamination and much simpler calibration, compared with the awkward and vulnerable optical geometry of the conventional imaging TS approach, currently under development by ITER. In the present work we have extended the simulation code used previously to include the case of launching two laser pulses, of different wavelengths, simultaneously in LIDAR geometry. The aim of this approach is to broaden the choice of lasers available for the diagnostic. In the simulation code it is assumed that two short duration (300 ps) laser pulses of different wavelengths, from an Nd:YAG laser are launched through the plasma simultaneously. The temperature and density profiles are deduced in the usual way but from the resulting combined scattered signals in the different spectral channels of the single spectrometer. The spectral response and quantum efficiencies of the detectors used in the simulation are taken from catalogue data for commercially available Hamamatsu MCP-PMTs. The response times, gateability and tolerance to stray light levels of this type of photomultiplier have already been demonstrated in the JET LIDAR system and give sufficient spatial resolution to meet the ITER specification. Here we present the new simulation results from the code. They demonstrate that when the detectors are combined with this two laser, LIDAR approach, the full range of the specified ITER core plasma Te and ne can be measured with sufficient accuracy. So, with commercially available detectors and a simple modification of a Nd:YAG laser similar to that currently being used in the design of the conventional ITER core TS design mentioned above, the ITER requirements can be met.

Wear and related evaluations of partially stabilized ZrO2

International Nuclear Information System (INIS)

Rice, R.W.; Wu, C.C.

1985-01-01

Pin-On-Disk (POD) tests show partially stabilized ZrO 2 (PSZ) crystals to have about the same wear as fully stabilized ZrO 2 crystals unit stabilizer contents are low enough (e.g., 4-5 wt % Y 2 O 3 ) so that some monoclinc ZrO 2 is present. Then wear increases substantially as stabilizer content is further reduced, and monoclinic content increases. Tests of PSZ-crystal cutting tools have not proved particularly successful, and rolling-contact fatigue tests of various PSZ materials showed them to be poor candidates for rolling-element bearings, with the later results indicating a petch-type dependence. Possible reasons for such limited or poor performance of PSZ, despite its good toughness, are discussed. Poor performance with concentrated loads is noted in particular, indicating limitations due to plastic flow

Evaluation of the egg transmission and pathogenicity of Mycoplasma gallisepticum isolates genotyped as ts-11.

Science.gov (United States)

Armour, Natalie K; Ferguson-Noel, Naola

2015-01-01

Live Mycoplasma gallisepticum vaccines are used for the control of respiratory disease, egg production losses and egg transmission associated with M. gallisepticum infection in long-lived poultry. The first field case of apparent increased virulence and vertical transmission of ts-11, a live M. gallisepticum vaccine, has been reported. In that study a M. gallisepticum isolate from the broiler progeny of ts-11-vaccinated breeders was genotyped as ts-11 by sequence analysis of four different genetic targets and Random Amplified Polymorphic DNA and found to be significantly more virulent than ts-11 vaccine. The objective of the current study was to evaluate the rate of egg transmission and pathogenicity of ts-11 vaccine and isolates recovered from ts-11-vaccinated breeders (K6222B) and their broiler progeny (K6216D) which had been genotyped as ts-11. Groups of 28-week-old specific pathogen-free chickens at 87% average weekly egg production were inoculated with sterile broth media (negative controls), ts-11 vaccine, K6222B, K6216D or R strain (positive controls) by eye-drop and aerosol. K6216D transmitted via the egg at an average rate of 4.0% in the third and fourth weeks post-infection, while egg transmission of K6222B and ts-11 vaccine was not detected. M. gallisepticum was isolated from the air sacs, ovaries and oviducts of hens infected with K6216D and K6222B, but not from those infected with ts-11 vaccine. K6216D and K6222B both induced respiratory signs and significantly more tracheal colonization and more severe tracheal and air sac lesions than ts-11 vaccine (P ≤ 0.05). There were no substantial differences in the egg production of ts-11, K6216D and K6222B infected groups. These results provide the first conclusive evidence of transovarian transmission of an isolate genotyped as ts-11 and indicate that isolates genotyed as ts-11 vary in their virulence and ability to transmit via the egg.

Operation and consolidation: lifetime of equipment and priorities TS

CERN Document Server

Béjar-Alonso, Isabel

2008-01-01

Since 1999 the TS department has benchmarked his services with the industry and other research laboratories and has prepared several consolidation plans. An evaluation of the results obtained from the different consolidation plans will be summarized. The difference between the projects achieved and those planned will be analyzed. The impact of the differed consolidation and of the maintenance backlog will be analyzed in order to present the future TS consolidation strategy

Do's and Don'ts for Liposuction

Science.gov (United States)

... for Every Season How to Choose the Best Skin Care Products In This Section Dermatologic Surgery What is dermatologic ... for Every Season How to Choose the Best Skin Care Products Do's and don’ts for liposuction Don’t ...

Identification and characterization of a Bacillus subtilis strain TS06 ...

African Journals Online (AJOL)

Replant disease is a major limitation for strawberry production in greenhouse. Bio-control may be a good way to cope with the replant diseases. Here, we report identification and characterization of a bacterial strain TS06 that may be used as a bio-control agent against the replant diseases in strawberry. TS06 was identified ...

Ceramics in engines - Long term stability of transformation toughened zirconia

International Nuclear Information System (INIS)

Marmach, M.; Swain, M.V.

1985-01-01

The long term thermal stability of two types of magnesia partially stabilized zirconia at temperatures below 1000 0 C has been determined. The effect on mechanical properties and phase stability of isothermal heating at 800 0 C and 900 0 C for up to 2000 hours, and with thermal cycling for a similar period between R.T. and 800 0 C in air, was measured. it was found that peak-aged (MS) type Mg-PSZ was much more stable than the thermal shock resistant (TS) type in both tests and showed minimal degradation

Precursor effect on the property and catalytic behavior of Fe-TS-1 in butadiene epoxidation

Science.gov (United States)

Wu, Mei; Zhao, Huahua; Yang, Jian; Zhao, Jun; Song, Huanling; Chou, Lingjun

2017-11-01

The effect of iron precursor on the property and catalytic behavior of iron modified titanium silicalite molecular sieve (Fe-TS-1) catalysts in butadiene selective epoxidation has been studied. Three Fe-TS-1 catalysts were prepared, using iron nitrate, iron chloride and iron sulfate as precursors, which played an important role in adjusting the textural properties and chemical states of TS-1. Of the prepared Fe-TS-1 catalysts, those modified by iron nitrate (FN-TS-1) exhibited a significant enhanced performance in butadiene selective epoxidation compared to those derived from iron sulfate (FS-TS-1) or iron chloride (FC-TS-1) precursors. To obtain a deep understanding of their structure-performance relationship, X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), Temperature programmed desorption of NH3 (NH3-TPD), Diffuse reflectance UV-Vis spectra (DR UV-Vis), Fourier transformed infrared spectra (FT-IR) and thermal gravimetric analysis (TGA) were conducted to characterize Fe-TS-1 catalysts. Experimental results indicated that textural structures and acid sites of modified catalysts as well as the type of Fe species influenced by the precursors were all responsible for the activity and product distribution.

Review of $V_{cb}$ and $V_{td}/V_{ts}$

OpenAIRE

Forty, Roger W

1997-01-01

The current experimental status of the CKM matrix element V_cb and the ratio V_td/V_ts is reviewed. Knowledge of these elements has a strong impact on the unitarity triangle, of interest for studies of CP violation in the B system. The measurements of V_cb from both inclusive semileptonic b decays and the exclusive channel B -> D* l nu are reaching high precision. For V_td/V_ts the strongest upper limit is derived from studies of B-Bbar mixing.

Transport of UF6 in compliance with TS-R-1

International Nuclear Information System (INIS)

Dekker, B.G.

2004-01-01

The IAEA Regulations TS-R-1 (ST-1, Revised) 1996 Edition include requirements for packages containing uranium hexafluoride (UF6); these are the first and only substance-specific requirements in the IAEA regulations. These requirements have already particularly affected, and will further affect, the transport of non-fissile and fissile excepted UF 6 and the packages used for these transports. Non-fissile and fissile excepted UF6 (ASTM C 787) has been transported worldwide for decades in a safe and reliable manner, using internationally standardised packages. Under the auspices of the World Nuclear Transport Institute (WNTI), an industry working group has been evaluating the existing packages against the requirements in TS-R-1. As new requirements came into effect, there were new challenges for the use of these standard packages, including the free drop test and the thermal requirements. In close cooperation with the WNTI HEXT Industry Working Group, a consortium of UF6 producers/users has worked together on the design and development, testing and certification of technical solutions for modification and optimisation of the existing packages to comply with TS-R-1. This paper reviews the existing standard packages against the requirements in TS-R-1. An update is also given describing the enhancements to the standard packages that have been designed and developed recently. The paper also describes how these solutions have been tested and certified, as well as the status of implementation. Finally, a review is made of the options that are available internationally to transport UF6 in compliance with TS-R-1. (author)

Kunstisuvi 1999 / Sirje Eelma, Rait Prääts

Index Scriptorium Estoniae

Eelma, Sirje, 1950-

1999-01-01

12. juunist näitus "Rahvusvaheline väikegraafika ja eesti väikeskulptuur" Kuressaare Raegaleriis. Koostajad ja kujundajad Sirje Eelma, Terje Ojaver. 19. juunist Haapsalu Linnagaleriis ja lisaruumides väljapanek "Motiiv". Koostajad Agur Kruusing, Sirje Eelma, Rait Prääts, kujundaja Agur Kruusing. Pärnu Linnagaleriis näitus "Minimaal". Koostaja ja kujundaja Rait Prääts. Muuseumiaidas eesti noorema kunsti väljapanek "Voolab". Koostaja Karol Kallas. Juuli lõpul Selgase dolomiidipäevad Kuressaares. Pärast põhinäituste lõppemist valiknäitus Paide Vallitornis

BlendCAC: A BLockchain-ENabled Decentralized Capability-based Access Control for IoTs

OpenAIRE

Xu, Ronghua; Chen, Yu; Blasch, Erik; Chen, Genshe

2018-01-01

The prevalence of Internet of Things (IoTs) allows heterogeneous embedded smart devices to collaboratively provide smart services with or without human intervention. While leveraging the large scale IoT based applications like Smart Gird or Smart Cities, IoTs also incur more concerns on privacy and security. Among the top security challenges that IoTs face, access authorization is critical in resource sharing and information protection. One of the weaknesses in today's access control (AC) is ...

A Federated Capability-based Access Control Mechanism for Internet of Things (IoTs)

OpenAIRE

Xu, Ronghua; Chen, Yu; Blasch, Erik; Chen, Genshe

2018-01-01

The prevalence of Internet of Things (IoTs) allows heterogeneous embedded smart devices to collaboratively provide intelligent services with or without human intervention. While leveraging the large-scale IoT-based applications like Smart Gird and Smart Cities, IoT also incurs more concerns on privacy and security. Among the top security challenges that IoTs face is that access authorization is critical in resource and information protection over IoTs. Traditional access control approaches, l...

Application of piezoceramic materials in low temperature scanning tunnel microscope

International Nuclear Information System (INIS)

Volodin, A.P.; Panich, A.E.

1989-01-01

Temperature dependences of the voltage-to-movement conversion coefficients for piezoceramic domestic materials PKR and TsTS-19 are measured using a capacitance dilatometer in the 0.4< T<300K temperature range. Anisotropy of thermal expansion of materials determined by the polarization vector is observed. Some recommendations concerning the use of the given materials in low-temperature scanning tunnel microscopes are given

Measurement of the CKM matrix element |V_ts|²

CERN Document Server

Unverdorben, Christopher Gerhard

This is the first direct measurement of the CKM matrix element |V_ts|, using data collected by the ATLAS detector in 2012 at √s=8 TeV pp-collisions with a total integrated luminosity of 20.3 fb⁻¹. The analysis is based on 112171 reconstructed tt̅ candidate events in the lepton+jets channel, having a purity of 90.0 %. 183 tt̅→WWbs̅ decays are expected (charge conjugation implied), which are available for the extraction of the CKM matrix element |V_ts|². To identify these rare decays, several observables are examined, such as the properties of jets, tracks and of b-quark identification algorithms. Furthermore, the s-quark hadrons K0s are considered, reconstructed by a kinematic fit. The best observables are combined in a multivariate analysis, called "boosted decision trees". The responses from Monte Carlo simulations are used as templates for a fit to data events yielding a significance value of 0.7σ for t→s+W decays. An upper limit of |V_ts|² < 1.74 % at 95 % confidence level is set, includi...

Advanced high temperature superconductor film-based process using RABiTS

International Nuclear Information System (INIS)

Goyal, A.; Hawsey, R.A.; Hack, J.; Moon, D.

2000-01-01

The purpose of this Cooperative Research and Development Agreement (CRADA) between Lockheed Martin Energy Research Corporation (Contractor), Managing contractor for Oak Ridge National Laboratory (ORNL) and Midwest Superconductivity, Inc. (MSI) and Westinghouse Science and Electric Company (WEC) was to develop the basis for a commercial process for the manufacturing of superconducting tape based on the RABiTS technology developed at ORNL. The chosen method for deposition of YBCO films on RABiTS was Metal Organic chemical Vapor Deposition (MOCVD)

Characterisation of Ceramic-Coated 316LN Stainless Steel Exposed to High-Temperature Thermite Melt and Molten Sodium

Science.gov (United States)

Ravi Shankar, A.; Vetrivendan, E.; Shukla, Prabhat Kumar; Das, Sanjay Kumar; Hemanth Rao, E.; Murthy, S. S.; Lydia, G.; Nashine, B. K.; Mallika, C.; Selvaraj, P.; Kamachi Mudali, U.

2017-11-01

Currently, stainless steel grade 316LN is the material of construction widely used for core catcher of sodium-cooled fast reactors. Design philosophy for core catcher demands its capability to withstand corium loading from whole core melt accidents. Towards this, two ceramic coatings were investigated for its application as a layer of sacrificial material on the top of core catcher to enhance its capability. Plasma-sprayed thermal barrier layer of alumina and partially stabilised zirconia (PSZ) with an intermediate bond coat of NiCrAlY are selected as candidate material and deposited over 316LN SS substrates and were tested for their suitability as thermal barrier layer for core catcher. Coated specimens were exposed to high-temperature thermite melt to simulate impingement of molten corium. Sodium compatibility of alumina and PSZ coatings were also investigated by exposing samples to molten sodium at 400 °C for 500 h. The surface morphology of high-temperature thermite melt-exposed samples and sodium-exposed samples was examined using scanning electron microscope. Phase identification of the exposed samples was carried out by x-ray diffraction technique. Observation from sodium exposure tests indicated that alumina coating offers better protection compared to PSZ coating. However, PSZ coating provided better protection against high-temperature melt exposure, as confirmed during thermite melt exposure test.

Deep-HiTS: Rotation Invariant Convolutional Neural Network for Transient Detection

Science.gov (United States)

Cabrera-Vives, Guillermo; Reyes, Ignacio; Förster, Francisco; Estévez, Pablo A.; Maureira, Juan-Carlos

2017-02-01

We introduce Deep-HiTS, a rotation-invariant convolutional neural network (CNN) model for classifying images of transient candidates into artifacts or real sources for the High cadence Transient Survey (HiTS). CNNs have the advantage of learning the features automatically from the data while achieving high performance. We compare our CNN model against a feature engineering approach using random forests (RFs). We show that our CNN significantly outperforms the RF model, reducing the error by almost half. Furthermore, for a fixed number of approximately 2000 allowed false transient candidates per night, we are able to reduce the misclassified real transients by approximately one-fifth. To the best of our knowledge, this is the first time CNNs have been used to detect astronomical transient events. Our approach will be very useful when processing images from next generation instruments such as the Large Synoptic Survey Telescope. We have made all our code and data available to the community for the sake of allowing further developments and comparisons at https://github.com/guille-c/Deep-HiTS. Deep-HiTS is licensed under the terms of the GNU General Public License v3.0.

Composite repairs qualification according to ISO/TS 24817

Energy Technology Data Exchange (ETDEWEB)

Meniconi, Luiz C.M.; Perrut, Valber A. [Petroleo Brasileiro S.A. (PETROBRAS/CENPES), Rio de Janeiro, RJ (Brazil). Centro de Pesquisas

2009-07-01

Composite repairs for metallic pipes from three different suppliers were evaluated according to ISO Technical Specification TS 24817. The intended application scenarios are offshore production plants, but the design methodology is also applicable to onshore pipelines and pipework. The evaluation covered all the relevant mechanical properties and established the maximum application temperatures for each repair system. The tests also considered the application of composite repair sleeves to metallic pipes with through thickness defects, by measuring the strain energy release rates of the composite-metal interfaces. The test campaigns aimed to verify the applicability of the recently published ISO document, and to implement it as the routine procedure for composite repairs evaluation within PETROBRAS. The tests also addressed the influence of metallic pipe surface preparation on the final properties of the repair sleeves, especially in relation to the long term behavior of leaking pipes repaired by means of composite materials. (author)

Arc Security System Based on Harmonics Detection for the TS ICRH Transmitter

International Nuclear Information System (INIS)

Berger-by, G.; Beaumont, B.; Lombard, G.; Millon, L.; Mollard, P.; Volpe, D.

2006-01-01

Since 1999 and with the help of I.P.P. (Institut fuer Plasmaphysik) Garching, we have tested in the Tore Supra (T.S.) ICRH transmitter, arcs security systems based on harmonics detection in a frequency band lower than the generator frequency. These systems have been designed for ASDEX in order to discriminate between the arcs and the ELMS mismatches during H-mode plasmas; they have been supplied to T.S. by a loan contract by I.P.P. The first tests done in T.S. were very successful and have permitted in 2000 to build a prototype matching T.S. technical requirements. These systems have some advantages in comparison with traditional securities which are based on use of a level on the V r /V f (Reflected to Forward voltage ratio) calculation . They do not use calculation, calibration with frequency or level. They can use RF signals from directional couplers or probes, so they are fully independent of the measurement systems. The detection bandwidth (4 MHz-35 MHz on TS) is independent of the antennae working frequencies. The detection principle is therefore insensitive to the crosstalk between the antennae and to the antennae coupling variations. The RF arc security box is installed in the generator hall which can be located far from the torus hall and the antennae (about 50 m on T.S.) a feature which is very relevant for the ITER transmitters. In 2001 we have built 3 systems based on our prototype in order to improve the protection of the 3 ICRH generators and antennae. These systems use industrial pass-band filters and a very sensitive linear detection (- 60 dBm) in order to facilitate the adjustment. Optical fibbers are used to transfer, with a very high immunity, the trip information to the generator electronic pilot. To guarantee safe operation, a checking test of the entire security chain is performed with a 10 MHz RF oscillator before each plasma start. The RF principle used on T.S. ICRH transmitter and its electronic interactions with the VME command control of

Simultaneous and multi-criteria optimization of TS requirements and maintenance at NPPs

International Nuclear Information System (INIS)

Martorell, S.; Sanchez, A.; Carlos, S.; Serradell, V.

2002-01-01

One of the main concerns of the nuclear industry is to improve the availability of safety-related systems at nuclear power plants (NPPs) to achieve high safety levels. The development of efficient testing and maintenance has been traditionally one of the different ways to guarantee high levels of systems availability, which are implemented at NPP through technical specification and maintenance requirements (TS and M). On the other hand, there is a widely recognized interest in using the probabilistic risk analysis (PRA) for risk-informed applications aimed to emphasize both effective risk control and effective resource expenditures at NPPs. TS and M-related parameters in a plant are associated with controlling risk or with satisfying requirements, and are candidate to be evaluated for their resource effectiveness in risk-informed applications. The resource versus risk-control effectiveness principles formally enter in optimization problems where the cost or the burden for the plant staff is to be minimized while the risk or the availability of the safety equipment is constrained to be at a given level, and vice versa. Optimization of TS and M has been found interesting from the very beginning. However, the resolution of such a kind of optimization problem has been limited to focus on only individual TS and M-related parameters (STI, AOT, PM frequency, etc.) and/or adopting an individual optimization criterion (availability, costs, plant risks, etc.). Nevertheless, a number of reasons exist (e.g. interaction, similar scope, etc.) that justify the growing interest in the last years to focus on the simultaneous and multi-criteria optimization of TS and M. In the simultaneous optimization of TS and M-related parameters based on risk (or unavailability) and cost, like in many other engineering optimization problems, one normally faces multi-modal and non-linear objective functions and a variety of both linear and non-linear constraints. Genetic algorithms (GAs) have

TS WEBSITE AND SOCIAL MEDIA ANALYTICS- DECEMBER 2016

Data.gov (United States)

Department of Veterans Affairs — This PowerPoint included accomplishments reached in December 2016, along with how many TS users and Pulse users there are currently. Not only does this PowerPoint...

TS WEBSITE AND SOCIAL MEDIA ANALYTICS NOVEMBER 2016

Data.gov (United States)

Department of Veterans Affairs — This PowerPoint included accomplishments reached in November 2016, along with how many TS users and Pulse users there are currently. Not only does this PowerPoint...

Advisory Material for the IAEA Regulations for the Safe Transport of Radioactive Material. Safety Guide (Spanish Edition)

International Nuclear Information System (INIS)

2010-01-01

This Safety Guide provides recommendations on achieving and demonstrating compliance with IAEA Safety Standards Series No. TS-R-1, Regulations for the Safe Transport of Radioactive Material, 2005 Edition, establishing safety requirements to be applied to the national and international transport of radioactive material. Transport is deemed to comprise all operations and conditions associated with and involved in the movement of radioactive material; these include the design, fabrication and maintenance of packaging, and the preparation, consigning, handling, carriage, storage in transit and receipt at the final destination of packages. This publication supersedes IAEA Safety Series No. TS-G-1.1, 2002 Edition

The Evolution of Thyroid Function after Presenting with Hashimoto Thyroiditis Is Different between Initially Euthyroid Girls with and Those without Turner Syndrome.

Science.gov (United States)

Wasniewska, Malgorzata; Salerno, Mariacarolina; Corrias, Andrea; Mazzanti, Laura; Matarazzo, Patrizia; Corica, Domenico; Aversa, Tommaso; Messina, Maria Francesca; De Luca, Filippo; Valenzise, Mariella

2016-01-01

To prospectively investigate, during a 5-year follow-up, whether the prognosis of thyroid function with Hashimoto thyroiditis (HT) is different in euthyroid girls with Turner syndrome (TS) than in euthyroid girls without TS. In 66 TS girls and 132 non-TS girls with euthyroid HT and similar thyroid functional test results at HT diagnosis, we followed up the evolution of thyroid status over time. At the end of follow-up, the TS girls exhibited higher TSH levels, lower fT4 levels, and lower prevalence rates of both euthyroidism and subclinical hypothyroidism, but higher prevalence rates of both overt hypothyroidism and hyperthyroidism, irrespective of the karyotype. An association with TS is able to impair the long-term prognosis of thyroid function in girls with HT. Such an effect occurs irrespective of thyroid functional test results at HT diagnosis and is not necessarily linked with a specific karyotype. © 2016 S. Karger AG, Basel.

Safe Transport of Radioactive Material, Philosophy and Overview

Energy Technology Data Exchange (ETDEWEB)

EL-Shinawy, R M.K. [Radiation Protection Dept., Nuclear Rasearch Center, Atomic Energy Authority, Cairo (Egypt)

2008-07-01

Safe transport of radioactive material regulations issued by IAEA since 1961, provide standards for insuring a high level of safety of people,transport workers, property and environment against radiation, contamination and criticality hazards as well as thermal effects associated with the transport of the radioactive wastes and material. The history ,development, philosophy and scope of these international and national regulations were mentioned as well as the different supporting documents to the regulations for safe transport of radioactive material were identified.The first supporting document , namely TS - G-1.1(ST-2) ,Advisory material is also issued by the IAEA.It contains both the advisory and explanatory materials previously published in safety series Nos 7and 37 and therefore TS-G-1.1 (ST-2) will supersede safety series Nos 7 and 37. The second supporting document namely TS-G-1.2 (ST-3), planning and preparing for emergency response to transport accidents involving radioactive material ,which will supersede safety series No 87. In addition to quality assurance (SS no.113), compliance assurance (SS no. 112), the training manual and others.

Safe Transport of Radioactive Material, Philosophy and Overview

International Nuclear Information System (INIS)

EL-Shinawy, R.M.K.

2008-01-01

Safe transport of radioactive material regulations issued by IAEA since 1961, provide standards for insuring a high level of safety of people,transport workers, property and environment against radiation, contamination and criticality hazards as well as thermal effects associated with the transport of the radioactive wastes and material. The history ,development, philosophy and scope of these international and national regulations were mentioned as well as the different supporting documents to the regulations for safe transport of radioactive material were identified.The first supporting document , namely TS - G-1.1(ST-2) ,Advisory material is also issued by the IAEA.It contains both the advisory and explanatory materials previously published in safety series Nos 7and 37 and therefore TS-G-1.1 (ST-2) will supersede safety series Nos 7 and 37. The second supporting document namely TS-G-1.2 (ST-3), planning and preparing for emergency response to transport accidents involving radioactive material ,which will supersede safety series No 87. In addition to quality assurance (SS no.113), compliance assurance (SS no. 112), the training manual and others

Cloning and Characterization of EF-Tu and EF-Ts from Pseudomonas aeruginosa

Directory of Open Access Journals (Sweden)

Stephanie O. Palmer

2013-01-01

Full Text Available We have cloned genes encoding elongation factors EF-Tu and EF-Ts from Pseudomonas aeruginosa and expressed and purified the proteins to greater than 95% homogeneity. Sequence analysis indicated that P. aeruginosa EF-Tu and EF-Ts are 84% and 55% identical to E. coli counterparts, respectively. P. aeruginosa EF-Tu was active when assayed in GDP exchange assays. Kinetic parameters for the interaction of EF-Tu with GDP in the absence of EF-Ts were observed to be = 33 μM, = 0.003 s−1, and the specificity constant was  s−1 μM−1. In the presence of EF-Ts, these values were shifted to = 2 μM, = 0.005 s−1, and the specificity constant was  s−1 μM−1. The equilibrium dissociation constants governing the binding of EF-Tu to GDP ( were 30–75 nM and to GTP ( were 125–200 nM. EF-Ts stimulated the exchange of GDP by EF-Tu 10-fold. P. aeruginosa EF-Tu was active in forming a ternary complex with GTP and aminoacylated tRNA and was functional in poly(U-dependent binding of Phe-tRNAPhe at the A-site of P. aeruginosa ribosomes. P. aeruginosa EF-Tu was active in poly(U-programmed polyphenylalanine protein synthesis system composed of all P. aeruginosa components.

Evaluation of the Airborne CASI/TASI Ts-VI Space Method for Estimating Near-Surface Soil Moisture

Directory of Open Access Journals (Sweden)

Lei Fan

2015-03-01

Full Text Available High spatial resolution airborne data with little sub-pixel heterogeneity were used to evaluate the suitability of the temperature/vegetation (Ts/VI space method developed from satellite observations, and were explored to improve the performance of the Ts/VI space method for estimating soil moisture (SM. An evaluation of the airborne ΔTs/Fr space (incorporated with air temperature revealed that normalized difference vegetation index (NDVI saturation and disturbed pixels were hindering the appropriate construction of the space. The non-disturbed ΔTs/Fr space, which was modified by adjusting the NDVI saturation and eliminating the disturbed pixels, was clearly correlated with the measured SM. The SM estimations of the non-disturbed ΔTs/Fr  space using the evaporative fraction (EF and temperature vegetation dryness index (TVDI were validated by using the SM measured at a depth of 4 cm, which was determined according to the land surface types. The validation results show that the EF approach provides superior estimates with a lower RMSE (0.023 m3·m−3 value and a higher correlation coefficient (0.68 than the TVDI. The application of the airborne ΔTs/Fr  space shows that the two modifications proposed in this study strengthen the link between the ΔTs/Fr space and SM, which is important for improving the precision of the remote sensing Ts/VI space method for monitoring SM.

Microwave sintering of hydroxyapatite-based composites

International Nuclear Information System (INIS)

Fang, Y.; Roy, D.M.; Cheng, J.; Roy, R.; Agrawal, D.K.

1993-01-01

Composites of hydroxyapatite/partially stabilized zirconia (HAp/PSZ) and hydroxyapatite/silicon carbide whiskers (HAp/SiC) were sintered at 1100-1200 degrees C by microwave at 2.45 GHz. Characterization of the sintered composites was carried out by density, microstructure, phase composition, and fracture toughness measurements. The results show that although not yet fully densified, a much higher sintered density in the HAp/PSZ composite was achieved by microwave sintering than by conventional sintering at the same temperature. A relative density of 93% was achieved by 20 min. microwave processing at 1200 degrees C. Comparatively, 2 h conventional sintering of the same material at 1200 degrees C led to only 75.5% relative density. K IC of this microwave sintered HAp/PSZ of 93% density was found to be 3.88 MPa√m, which is 250% of the value for pure HAp of the same density. A further increase in K IC could be expected if full or nearly full densification was achieved. Sintering of PSZ particles in the HAp/PSZ composite was also observed in the microwave processed sample. Microwave sintering of HAp/SiC was not successful in the current study due to the oxidation of SiC in air at high temperature. 8 refs., 4 figs., 1 tab

Electromagnetic noise spectrum at John TS [transmission station

International Nuclear Information System (INIS)

Hatanaka, G.K.

1992-01-01

Canadian National (CN) is proposing the development of a commercial office tower on a site directly south of John Transmission Station (TS). CN is concerned about the potential effects of fields originating from John TS and other nearby sources on the operation of sensitive equipment and occupants of the building. Potential equipment and tenants might include data processing equipment and television and radio broadcasting companies. A study was conducted to characterize the severity of the electromagnetic environment at the site in order to address these concerns. Measurements of the electromagnetic spectrum from 100 kHz to 300 MHz were performed from a mobile test facility that features a 5 kW diesel generator and an extendible antenna mast. Peak measurements were made using a selectable measurement time of 0.05 s. It was found that the highest noise levels result from micro-gap discharges under dry weather conditions. The micro-gap discharges are characteristic of defect noise sources associated with substation hardware. At 0.5 MHz the noise levels are typical of median noise levels expected for the International Radio Consultive Committee (CCIR) defined business environment. At 74 MHz the noise levels are more severe than the expected levels for this type of environment. However, levels more representative of the business environment will be achieved by eliminating the micro-gap noise sources attributed to John TS. 6 refs., 11 figs., 2 tabs

Konstantin Päts ja NSV Liidu Tallinna saatkond / Magnus Ilmjärv

Index Scriptorium Estoniae

Ilmjärv, Magnus, 1961-

1999-01-01

Järg Sep/13,14,15,16,17,18,20,21,22,22 lk. 17,21,17,18,18,16,17,21,18,14. Päts kui Nõukogude saatkonna lobitegija. Välisminister Pusta kangutamine. Pätsi info venelastele J. Tõnissoni kohta. Balti riikide vahelise koostöö takistamine. J. Puhk tõmmati venelaste mõjusfääri. Päts nõuab Eesti valitsuselt uut kaubanduslepingut venelastega

Photocatalytic hydrogen generation over Eosin Y-Sensitized TS-1 zeolite

International Nuclear Information System (INIS)

Zhang Xiaojie; Jin Zhiliang; Li Yuexiang; Li Shuben; Lu Gongxuan

2008-01-01

Eosin Y-sensitized TS-1 zeolite was studied for the photo-reduction of water into hydrogen driven by visible light (λ ≥ 420 nm). The optimal pH and weight ratio between Eosin Y and TS-1 zeolite is 7 and 1/8, respectively. In the presence of triethanolamine (TEA) as an electron donor, the highest rate of hydrogen generation and apparent quantum efficiency are 34 μmol h -1 and 9.4%, respectively, under visible light irradiation (λ ≥ 420 nm). Short-term stability test indicates that the catalyst is rather stable during 50 h photoreaction

Photocatalytic hydrogen generation over Eosin Y-Sensitized TS-1 zeolite

Energy Technology Data Exchange (ETDEWEB)

Zhang Xiaojie [State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Tianshui Zhong Road 18, Lanzhou 730000 (China); Graduate University of the Chinese Academy of Sciences, Beijing 100101 (China); Jin Zhiliang [State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Tianshui Zhong Road 18, Lanzhou 730000 (China); Li Yuexiang [Department of Chemistry, Nanchang University, Nanjing Road 245, Nanchang 330047 (China); Li Shuben [State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Tianshui Zhong Road 18, Lanzhou 730000 (China); Lu Gongxuan [State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Tianshui Zhong Road 18, Lanzhou 730000 (China)], E-mail: gxlu@lzb.ac.cn

2008-05-30

Eosin Y-sensitized TS-1 zeolite was studied for the photo-reduction of water into hydrogen driven by visible light ({lambda} {>=} 420 nm). The optimal pH and weight ratio between Eosin Y and TS-1 zeolite is 7 and 1/8, respectively. In the presence of triethanolamine (TEA) as an electron donor, the highest rate of hydrogen generation and apparent quantum efficiency are 34 {mu}mol h{sup -1} and 9.4%, respectively, under visible light irradiation ({lambda} {>=} 420 nm). Short-term stability test indicates that the catalyst is rather stable during 50 h photoreaction.

Bureau de documentation TS/EL/DO

CERN Document Server

Dujardin, M

2004-01-01

Le bureau de documentation a comme responsabilité de fournir et manager toute la documentation nécessaire au groupe TS-EL. Ce travail utilise des outils CAO (EUCLID- AUTOCAD) et de gestion de base de donnés ORACLE (GESMAR,EDMS) largement utilisé dans le département TS mais aussi des applications métiers tel que le transfert des donnés CAO vers les bases de données, le cheminement automatique ou la schématique électrique. La section se concentre sur des études de grands ensembles et l'intégration 3D des équipements électriques. Les études de services généraux sont généralement sous-traitées. Le projet LHC occupe actuellement la quasi totalité de nos ressources. Pour mener à bien les études électriques du LHC, caractérisées par une définition tardive des besoins et de nombreuses modifications, une structure souple et réactive a été mis en place : Une cellule CAO 3D EUCLID, en charge des layouts d'équipements et des cheminements, en relation avec l'intégration, et une cellule d'é...

REAC/TS radiation accident registry. Update of accidents in the United States

International Nuclear Information System (INIS)

Ricks, R.C.; Berger, M.E.; Holloway, E.C.; Goans, R.E.

2000-01-01

Serious injury due to ionizing radiation is a rare occurrence. From 1944 to the present, 243 US accidents meeting dose criteria for classification as serious are documented in the REAC/TS Registry. Thirty individuals have lost their lives in radiation accidents in the United States. The Registry is part of the overall REAC/TS program providing 24-hour direct or consultative assistance regarding medical and heath physics problems associated with radiation accidents in local, national, and international incidents. The REAC/TS Registry serves as a repository of medically important information documenting the consequences of these accidents. Registry data are gathered from various sources. These include reports from the World Heath Organization (WHO), International Atomic Energy Agency (IAEA), US Nuclear Regulatory Commission (US NRC), state radiological health departments, medical/health physics literature, personal communication, the Internet, and most frequently, from calls for medical assistance to REAC/TS, as part of our 24-hour medical assistance program. The REAC/TS Registry for documentation of radiation accidents serves several useful purposes: 1) weaknesses in design, safety practices, training or control can be identified, and trends noted; 2) information regarding the medical consequences of injuries and the efficacy of treatment protocols is available to the treating physician; and 3) Registry case studies serve as valuable teaching tools. This presentation will review and summarize data on the US radiation accidents including their classification by device, accident circumstances, and frequency by respective states. Data regarding accidents with fatal outcomes will be reviewed. The inclusion of Registry data in the IAEA's International Reporting System of Radiation Events (RADEV) will also be discussed. (author)

T.S. ELIOT'S MISREADING OF SOME LITERARY SOURCES IN THE WASTE LAND

Directory of Open Access Journals (Sweden)

Liem Satya Limanta

2002-01-01

Full Text Available A poet cannot be a poet at all if he is not connected with all the poetic tradition before him. This is T.S. Eliot's dictum which he stated in Tradition and the Individual Talent and which he practiced in his work The Waste Land. T.S. Eliot showed his relationship with the past through all the quotations and allusions to mythical, literary, and religious works. His reading of those sources according to Paul de Man cannot avoid misreading or misinterpretation. Harold Bloom has tried to build up a theory of misreading, which he prefers to call misprision, especially applied to and done by poets in The Anxiety of Influence. Throughout this article I shall show how T.S. Eliot has applied some of the ways Bloom describes in reading some of the literary sources, and by so doing Eliot has given new meaning to them.

Agent Based Fuzzy T-S Multi-Model System and Its Applications

Directory of Open Access Journals (Sweden)

Xiaopeng Zhao

2015-11-01

Full Text Available Based on the basic concepts of agent and fuzzy T-S model, an agent based fuzzy T-S multi-model (ABFT-SMM system is proposed in this paper. Different from the traditional method, the parameters and the membership value of the agent can be adjusted along with the process. In this system, each agent can be described as a dynamic equation, which can be seen as the local part of the multi-model, and it can execute the task alone or collaborate with other agents to accomplish a fixed goal. It is proved in this paper that the agent based fuzzy T-S multi-model system can approximate any linear or nonlinear system at arbitrary accuracy. The applications to the benchmark problem of chaotic time series prediction, water heater system and waste heat utilizing process illustrate the viability and the efficiency of the mentioned approach. At the same time, the method can be easily used to a number of engineering fields, including identification, nonlinear control, fault diagnostics and performance analysis.

Physics and measurements of magnetic materials

CERN Document Server

Sgobba, S

2010-01-01

Magnetic materials, both hard and soft, are used extensively in several components of particle accelerators. Magnetically soft iron-nickel alloys are used as shields for the vacuum chambers of accelerator injection and extraction septa; Fe-based material is widely employed for cores of accelerator and experiment magnets; soft spinel ferrites are used in collimators to damp trapped modes; innovative materials such as amorphous or nanocrystalline core materials are envisaged in transformers for high-frequency polyphase resonant convertors for application to the International Linear Collider (ILC). In the field of fusion, for induction cores of the linac of heavy-ion inertial fusion energy accelerators, based on induction accelerators requiring some 107 kg of magnetic materials, nanocrystalline materials would show the best performance in terms of core losses for magnetization rates as high as 105 T/s to 107 T/s. After a review of the magnetic properties of materials and the different types of magnetic behaviour...

Digastric Muscle Phenotypes of the Ts65Dn Mouse Model of Down Syndrome.

Directory of Open Access Journals (Sweden)

Tiffany J Glass

Full Text Available Down syndrome is frequently associated with complex difficulties in oromotor development, feeding, and swallowing. However, the muscle phenotypes underlying these deficits are unclear. We tested the hypotheses that the Ts65Dn mouse model of DS has significantly altered myosin heavy chain (MyHC isoform profiles of the muscles involved in feeding and swallowing, as well as reductions in the speed of these movements during behavioral assays. SDS-PAGE, immunofluorescence, and qRT-PCR were used to assess MyHC isoform expression in pertinent muscles, and functional feeding and swallowing performance were quantified through videofluoroscopy and mastication assays. We found that both the anterior digastric (ADG and posterior digastric (PDG muscles in 11-day old and 5-6 week old Ts65Dn groups showed significantly lower MyHC 2b protein levels than in age-matched euploid control groups. In videofluoroscopic and videotape assays used to quantify swallowing and mastication performance, 5-6 week old Ts65Dn and euploid controls showed similar swallow rates, inter-swallow intervals, and mastication rates. In analysis of adults, 10-11 week old Ts65Dn mice revealed significantly less MyHC 2b mRNA expression in the posterior digastric, but not the anterior digastric muscle as compared with euploid controls. Analysis of MyHC 2b protein levels across an adult age range (10-53 weeks of age revealed lower levels of MyHC 2b protein in the PDG of Ts65Dn than in euploids, but similar levels of MyHC 2b in the ADG. Cumulatively, these results indicate biochemical differences in some, but not all, muscles involved in swallowing and jaw movement in Ts65Dn mice that manifest early in post-natal development, and persist into adulthood. These findings suggest potential utility of this model for future investigations of the mechanisms of oromotor difficulties associated with Down syndrome.

A Combination of TsHARP and Thin Plate Spline Interpolation for Spatial Sharpening of Thermal Imagery

Directory of Open Access Journals (Sweden)

Xuehong Chen

2014-03-01

Full Text Available There have been many studies and much attention paid to spatial sharpening for thermal imagery. Among them, TsHARP, based on the good correlation between vegetation index and land surface temperature (LST, is regarded as a standard technique because of its operational simplicity and effectiveness. However, as LST is affected by other factors (e.g., soil moisture in the areas with low vegetation cover, these areas cannot be well sharpened by TsHARP. Thin plate spline (TPS is another popular downscaling technique for surface data. It has been shown to be accurate and robust for different datasets; however, it has not yet been attempted in thermal sharpening. This paper proposes to combine the TsHARP and TPS methods to enhance the advantages of each. The spatially explicit errors of these two methods were firstly estimated in theory, and then the results of TPS and TsHARP were combined with the estimation of their errors. The experiments performed across various landscapes and data showed that the proposed combined method performs more robustly and accurately than TsHARP.

How can geological datasets help us to choose between rheological behaviours suggested by experimental measurements? Examples from the Alpine Fault and the Japan Trench.

Science.gov (United States)

Toy, V.; Boulton, C. J.; Coffey, G.; Denys, P. H.; McCaffrey, R.

2015-12-01

Laboratory measurements of fault rock rheology are commonly performed on individual components of complex natural systems. Textural and structural inferences from outcrop observations provide one means to constrain the co-operative behaviour of multi-component natural fault systems. For example, the principal slip zone (PSZ) of New Zealand's central Alpine Fault comprises a 1-10 cm thick sandwich of impermeable smectite-bearing ultracataclasite/gouge layers between higher permeability hanging wall cataclasite and footwall gravel (Boulton et al., 2012, doi: 10.1029/2011GC003872). Based solely on measured mechanical properties we expect earthquake ruptures to nucleate and propagate in the cataclasites rather than the PSZ. However, the PSZ gouge was preferentially comminuted so it must localise slip, and injection veins penetrate from it into the surrounding formation. This suggests that the gouge experiences coseismic pressurization and weakening, possible if slip is confined to one layer within the impermeable (thus undrained) gouge. On the southern Alpine Fault a clear PSZ is not well-developed; instead a wide shear zone crops out (Barth et al., 2013, doi: 10.1002/tect.20041). Mechanical data again demonstrate frictionally weak, velocity strengthening, low permeability materials, compatible with a creeping shear zone, but PSZ materials display velocity weakening behaviour at high slip rates if undrained, from which we infer seismic slip is possible in nature. Extensive paleoseismic records suggest the structure has accommodated regularly repeating earthquakes for the last 17 kyr (Berryman et al., 2013, doi: 10.1126/science.1218959). Our newly gathered geodetic datasets may resolve this apparent slip rate paradox. In situ measurements from active fault systems can also help interpret experimental data. For example, in material recovered from around the active slip zone of the 2011 Tohoku-oki earthquake, experiments suggest lower frictional strength for undrained

SAS4A and FPIN2X validation for slow ramp TOP accidents: experiments TS-1 and TS-2

International Nuclear Information System (INIS)

Hill, D.J.

1986-01-01

The purpose of this paper is to present further results in the series of experimental analyses being performed using SAS4A and FPIN2X in order to provide a systematic validation of these codes. The two experiments discussed here, TS-1 and TS-2, were performed by Westinghouse Hanford/Hanford Engineering Development Laboratory (WHC/HEDL) in the Transient Reactor Test (TREAT) Facility. They were slow ramp transient overpowers (TOPs) of ∼ 5 cent/s equivalent Fast Flux Test Facility (FFTF) ramp rate, single-pin experiments in flowing sodium loops. The good agreement found here adds significantly to the experimental data base that provides the foundation for SAS4A and FPIN2X validation. It also shows that prefailure internal fuel motion is a phenomenon that has to be correctly accounted for, not only as a potential inherent safety mechanism, but also before any accurate prediction of fuel failure and subsequent fuel motion and the associated reactivity effects can be made. This is also true for metal-fueled pins. This capability is provided by PINACLE, which is being incorporated into SAS4A

Safe Transport of Radioactive Material, International Regulations and its Supporting Documents

International Nuclear Information System (INIS)

El-Shinawy, R.M.K.

2005-01-01

Safe transport of radioactive material regulations issued by IAEA since 1961, provide standards for insuring a high level of safety of people,transport workers, property and environment against radiation, contamination and criticality hazards as well as thermal effects associated with the transport of the radioactive wastes and material. The history ,development, philosophy and scope of these international regulations were mentioned as well as the different supporting documents to the regulations for safe transport of radioactive material were identified.The first supporting document , namely TS - G-1.1 ( ST-2) ,Advisory material is also issued by the IAEA.It contains both the advisory and explanatory materials previously published in safety series No 7 and 37 and therefore TS-G-1.1 (ST-2) will supersede safety series No 7 and 37. The second supporting document namely TS-G-1.2 (ST-3), planning and preparing for emergency response to transport accidents involving radioactive material ,which will supersede safety series No 87. In addition to quality assurance (SS=113), compliance assurance (SS=112), the training manual and other

Safe Transport of Radioactive Material, International Regulations and its Supporting Documents

Energy Technology Data Exchange (ETDEWEB)

El-Shinawy, R M.K. [Radiation Protection Dept., NRC, Atomic Energy Authority, Cairo (Egypt)

2005-04-01

Safe transport of radioactive material regulations issued by IAEA since 1961, provide standards for insuring a high level of safety of people,transport workers, property and environment against radiation, contamination and criticality hazards as well as thermal effects associated with the transport of the radioactive wastes and material. The history ,development, philosophy and scope of these international regulations were mentioned as well as the different supporting documents to the regulations for safe transport of radioactive material were identified.The first supporting document , namely TS - G-1.1 ( ST-2) ,Advisory material is also issued by the IAEA.It contains both the advisory and explanatory materials previously published in safety series No 7 and 37 and therefore TS-G-1.1 (ST-2) will supersede safety series No 7 and 37. The second supporting document namely TS-G-1.2 (ST-3), planning and preparing for emergency response to transport accidents involving radioactive material ,which will supersede safety series No 87. In addition to quality assurance (SS=113), compliance assurance (SS=112), the training manual and other.

76 FR 50331 - Hazardous Materials Regulations; Compatibility With the Regulations of the International Atomic...

Science.gov (United States)

2011-08-12

... geometry requirements applicable to tested fissile material packages. This TS-R-1 change is applicable to... percussion test.) The TS-R-1 revisions pertaining to the solar insolation conditions to be assumed in...

Enhanced catalytic oxidation by hierarchically structured TS-1 zeolite

NARCIS (Netherlands)

Xin, H.; Zhao, Jiao; Zhao, J.; Xu, S.; Li, Junping; Zhang, Weiping; Guo, X.; Hensen, E.J.M.; Yang, Q.; Li, Can

2010-01-01

A TS-1 zeolite with a disordered network of mesopores penetrating the microporous crystalline zeolite framework was successfully synthesized by a one-pot carbon hard-templating synthesis approach. Besides conventional methods to characterize the mesoporosity, the use of variable-temperature 129Xe

A Solution-Based Temperature Sensor Using the Organic Compound CuTsPc

Directory of Open Access Journals (Sweden)

Shahino Mah Abdullah

2014-06-01

Full Text Available An electrochemical cell using an organic compound, copper (II phthalocyanine-tetrasulfonic acid tetrasodium salt (CuTsPc, has been fabricated and investigated as a solution-based temperature sensor. The capacitance and resistance of the ITO/CuTsPc solution/ITO chemical cell has been characterized as a function of temperature in the temperature range of 25–80 °C. A linear response with minimal hysteresis is observed. The fabricated temperature sensor has shown high consistency and sensitive response towards a specific range of temperature values.

ENVIRONMENTAL TECHNOLOGY VERIFICATION: JOINT (NSF-EPA) VERIFICATION STATEMENT AND REPORT: TRITON SYSTEMS, LLC SOLID BOWL CENTRIFUGE, MODEL TS-5000

Science.gov (United States)

Verification testing of the Triton Systems, LLC Solid Bowl Centrifuge Model TS-5000 (TS-5000) was conducted at the Lake Wheeler Road Field Laboratory Swine Educational Unit in Raleigh, North Carolina. The TS-5000 was 48" in diameter and 30" deep, with a bowl capacity of 16 ft3. ...

Development of an Operational TS Dataset Production System for the Data Assimilation System

Science.gov (United States)

Kim, Sung Dae; Park, Hyuk Min; Kim, Young Ho; Park, Kwang Soon

2017-04-01

An operational TS (Temperature and Salinity) dataset production system was developed to provide near real-time data to the data assimilation system periodically. It collects the latest 15 days' TS data of the north western pacific area (20°N - 55°N, 110°E - 150°E), applies QC tests to the archived data and supplies them to numerical prediction models of KIOST (Korea Institute of Ocean Science and Technology). The latest real-time TS data are collected from Argo GDAC and GTSPP data server every week. Argo data are downloaded from /latest_data directory of Argo GDAC. Because many duplicated data exist when all profile data are extracted from all Argo netCDF files, DB system is used to avoid duplication. All metadata (float ID, location, observation date and time, etc) of all Argo floats is stored into Database system and a Matlab program was developed to manipulate DB data, to check the duplication and to exclude duplicated data. GTSPP data are downloaded from /realtime directory of GTSPP data service. The latest data except ARGO data are extracted from the original data. Another Matlab program was coded to inspect all collected data using 10 QC tests and produce final dataset which can be used by the assimilation system. Three regional range tests to inspect annual, seasonal and monthly variations are included in the QC procedures. The C program was developed to provide regional ranges to data managers. It can calculate upper limit and lower limit of temperature and salinity at depth from 0 to 1550m. The final TS dataset contains the latest 15 days' TS data in netCDF format. It is updated every week and transmitted to numerical modeler of KIOST for operational use.

Study of the Integration of the CNU-TS-1 Mobile Tunnel Monitoring System.

Science.gov (United States)

Du, Liming; Zhong, Ruofei; Sun, Haili; Zhu, Qiang; Zhang, Zhen

2018-02-01

A rapid, precise and automated means for the regular inspection and maintenance of a large number of tunnels is needed. Based on the depth study of the tunnel monitoring method, the CNU-TS-1 mobile tunnel monitoring system (TS1) is developed and presented. It can efficiently obtain the cross-sections that are orthogonal to the tunnel in a dynamic way, and the control measurements that depend on design data are eliminated. By using odometers to locate the cross-sections and correcting the data based on longitudinal joints of tunnel segment lining, the cost of the system has been significantly reduced, and the interval between adjacent cross-sections can reach 1-2 cm when pushed to collect data at a normal walking speed. Meanwhile, the relative deformation of tunnel can be analyzed by selecting cross-sections from original data. Through the measurement of the actual tunnel, the applicability of the system for tunnel deformation detection is verified, and the system is shown to be 15 times more efficient than that of the total station. The simulation experiment of the tunnel deformation indicates that the measurement accuracy of TS1 for cross-sections is 1.1 mm. Compared with the traditional method, TS1 improves the efficiency as well as increases the density of the obtained points.

Study of the Integration of the CNU-TS-1 Mobile Tunnel Monitoring System

Directory of Open Access Journals (Sweden)

Liming Du

2018-02-01

Full Text Available A rapid, precise and automated means for the regular inspection and maintenance of a large number of tunnels is needed. Based on the depth study of the tunnel monitoring method, the CNU-TS-1 mobile tunnel monitoring system (TS1 is developed and presented. It can efficiently obtain the cross-sections that are orthogonal to the tunnel in a dynamic way, and the control measurements that depend on design data are eliminated. By using odometers to locate the cross-sections and correcting the data based on longitudinal joints of tunnel segment lining, the cost of the system has been significantly reduced, and the interval between adjacent cross-sections can reach 1–2 cm when pushed to collect data at a normal walking speed. Meanwhile, the relative deformation of tunnel can be analyzed by selecting cross-sections from original data. Through the measurement of the actual tunnel, the applicability of the system for tunnel deformation detection is verified, and the system is shown to be 15 times more efficient than that of the total station. The simulation experiment of the tunnel deformation indicates that the measurement accuracy of TS1 for cross-sections is 1.1 mm. Compared with the traditional method, TS1 improves the efficiency as well as increases the density of the obtained points.

Hypocellularity in the Murine Model for Down Syndrome Ts65Dn Is Not Affected by Adult Neurogenesis

Science.gov (United States)

López-Hidalgo, Rosa; Ballestín, Raul; Vega, Jessica; Blasco-Ibáñez, José M.; Crespo, Carlos; Gilabert-Juan, Javier; Nácher, Juan; Varea, Emilio

2016-01-01

Down syndrome (DS) is caused by the presence of an extra copy of the chromosome 21 and it is the most common aneuploidy producing intellectual disability. Neural mechanisms underlying this alteration may include defects in the formation of neuronal networks, information processing and brain plasticity. The murine model for DS, Ts65Dn, presents reduced adult neurogenesis. This reduction has been suggested to underlie the hypocellularity of the hippocampus as well as the deficit in olfactory learning in the Ts65Dn mice. Similar alterations have also been observed in individuals with DS. To determine whether the impairment in adult neurogenesis is, in fact, responsible for the hypocellularity in the hippocampus and physiology of the olfactory bulb, we have analyzed cell proliferation and neuronal maturation in the two major adult neurogenic niches in the Ts656Dn mice: the subgranular zone (SGZ) of the hippocampus and the subventricular zone (SVZ). Additionally, we carried out a study to determine the survival rate and phenotypic fate of newly generated cells in both regions, injecting 5′BrdU and sacrificing the mice 21 days later, and analyzing the number and phenotype of the remaining 5′BrdU-positive cells. We observed a reduction in the number of proliferating (Ki67 positive) cells and immature (doublecortin positive) neurons in the subgranular and SVZ of Ts65Dn mice, but we did not observe changes in the number of surviving cells or in their phenotype. These data correlated with a lower number of apoptotic cells (cleaved caspase 3 positive) in Ts65Dn. We conclude that although adult Ts65Dn mice have a lower number of proliferating cells, it is compensated by a lower level of cell death. This higher survival rate in Ts65Dn produces a final number of mature cells similar to controls. Therefore, the reduction of adult neurogenesis cannot be held responsible for the neuronal hypocellularity in the hippocampus or for the olfactory learning deficit of Ts65Dn mice

In vivo cell kinetic measurements in a randomized trial of continuous hyperfractionated accelerated radiotherapy with or without mitomycin C in head-and-neck cancer

International Nuclear Information System (INIS)

Dobrowsky, Werner; Dobrowsky, Eva; Wilson, George D.

2003-01-01

Purpose: Tumor cell repopulation is still considered to be a major cause of failure in radiotherapy. In this study, we investigated the influence of cell kinetic parameters on the outcome of patients treated in a randomized trial of accelerated fractionation, with or without mitomycin C, vs. conventional fractionation. Methods and Materials: Sixty-two patients were studied using administration of bromodeoxyuridine (BrdUrd), and cell kinetic parameters were measured using flow cytometry. The patients were treated with either 70 Gy for 7 weeks or 55.3 Gy for 17 continuous days (V-CHART) with or without 20 mg/m 2 mitomycin C on day 5. Results: The potential doubling time (Tpot) and labeling index (LI) failed to provide any prognostic information with regard to local control or survival. However, the duration of the S phase (Ts) revealed patients whose tumors had a long Ts had significantly worse local control (p = 0.028) and survival (p = 0.034) irrespective of treatment. A similar trend was evident within the different treatment arms particularly associated with overall survival. Conclusions: The Ts values of head-and-neck squamous cell cancers provided prognostic information that predicted clinical outcome irrespective of treatment schedule in this study. This neglected parameter of the Tpot method might provide information related to redistribution of cells during fractionated radiotherapy

Aleksandr Gol’ts, Armiia Rossii: 11 poteriannykh let, Moscow: Zakharov, 2004, 224 pp.

Directory of Open Access Journals (Sweden)

Richard F. Staar

2004-07-01

Full Text Available Specialist of military questions, Aleksandr Gol’ts worked for Red Star (Krasnaia Zvezda, the newspaper of the Russian Ministry of Defense, before joining various prestigious magazines such as Itogi. He is considered one of the most prominent journalist on military matters in Russia today. His book, “The Russian Army : 11 lost years”, is dedicated to military reforms in post-Soviet Russia. With his extensive knowledge of institutional realities of the military establishment, Gol’ts provides a...

Move of Purchasing Offices TS – AB* – AT*

CERN Multimedia

FI Department

2008-01-01

The TS – AB* - AT* Purchasing Offices and the Purchasing Pool have moved to Building 5 – 2nd and *3rd floors. The phone and fax numbers are unchanged. We apologize for any inconvenience caused by the move. Thank you for your understanding. Finance Department – Purchasing Service.

The impact of ISO/TS 16949 on automotive industries and created organizational capabilities from its implementation

Directory of Open Access Journals (Sweden)

Bakhtiar Ostadi

2010-12-01

Full Text Available ISO/TS 16949 is an ISO Technical Specification. ISO/TS 16949 achieves the objectives which are continually to improve the production of automobile parts and related services, and to strengthen the international competition for the automotive industry and its suppliers. By applying this quality system standard, automotive manufacturers could offer superior products and good services to customers. The more the companies know about the benefits if quality management systems such as ISO/TS 16949, better they can seek interest and determine indices of these systems. So, this standard has been implemented in companies considering a number of benefits. In this paper, we carry out an empirical study in order to verify the importance these benefits and ranking them based on the value of importance. Finally, the study tends to provide a reference guide considering benefits assessment and created organizational capabilities from this standard for the automotive industry in pursuing ISO/TS 16949 and procuring maximum benefit from the results.

"Cremaster' tsükkel" : Matthew Barney avastusretk kunsti ja filmikunsti vahealal / Miriam Dagan ; tõlk. Epp Aareleid

Index Scriptorium Estoniae

Dagan, Miriam

2007-01-01

Ameerika kunstniku ja režissööri kunstnikufilmidest "Cremaster' tsükkel" (1994-2002). Viie tsükli põhisündmusest. Viienda filmi rekvisiitor oli Meeli Salumäe, Kostabi Maailma assistent New Yorgis

The Prediction of the Gas Utilization Ratio based on TS Fuzzy Neural Network and Particle Swarm Optimization.

Science.gov (United States)

Zhang, Sen; Jiang, Haihe; Yin, Yixin; Xiao, Wendong; Zhao, Baoyong

2018-02-20

Gas utilization ratio (GUR) is an important indicator that is used to evaluate the energy consumption of blast furnaces (BFs). Currently, the existing methods cannot predict the GUR accurately. In this paper, we present a novel data-driven model for predicting the GUR. The proposed approach utilized both the TS fuzzy neural network (TS-FNN) and the particle swarm algorithm (PSO) to predict the GUR. The particle swarm algorithm (PSO) is applied to optimize the parameters of the TS-FNN in order to decrease the error caused by the inaccurate initial parameter. This paper also applied the box graph (Box-plot) method to eliminate the abnormal value of the raw data during the data preprocessing. This method can deal with the data which does not obey the normal distribution which is caused by the complex industrial environments. The prediction results demonstrate that the optimization model based on PSO and the TS-FNN approach achieves higher prediction accuracy compared with the TS-FNN model and SVM model and the proposed approach can accurately predict the GUR of the blast furnace, providing an effective way for the on-line blast furnace distribution control.

77 FR 43817 - Notice of Submission for OMB Review; Office of Postsecondary Education; Talent Search (TS) Annual...

Science.gov (United States)

2012-07-26

...; Talent Search (TS) Annual Performance Report SUMMARY: The Talent Search program provides Federal... Records Management Services, Office of Management, publishes this notice containing proposed information... records. Title of Collection: Talent Search (TS) Annual Performance Report. OMB Control Number: Pending...

A novel stabilization condition for T-S polynomial fuzzy system with time-delay:A sum-of-squares approach

OpenAIRE

Tsai, Shun Hung; Chen, Yu-An; Chen, Yu-Wen; Lo, Ji-Chang; Lam, Hak-Keung

2017-01-01

A novel stabilization problem for T-S polynomial fuzzy system with time-delay is investigated in this paper. Firstly, a polynomial fuzzy controller for T-S polynomial fuzzy system with time-delay is proposed. In addition, based on polynomial Lyapunov-Krasovskii function and the developed polynomial slack variable matrices, a novel stabilization condition for T-S polynomial fuzzy system with time-delay is presented in terms of sum-of-square (SOS) form. Lastly, nonlinear system with time-delay ...

Thermal analysis of the drywell for the Nuclear Material Storage Facility

International Nuclear Information System (INIS)

Steinke, R.G.

1997-01-01

The Nuclear Materials Storage Facility Renovation Project has a conceptual design for the facility to store nuclear materials in containers inside drywells with passive cooling for long-term storage. The CFX thermal-hydraulic computer program was used to analyze internal heat-transfer processes by conduction, convection, and radiation with natural circulation of air by hydraulic buoyancy with turbulence and thermal stratification (TS) evaluated. A vertical drywell was modeled with 14 containers on support plates at 12-in. intervals. The TS of bay air outside the drywell increased the container maximum temperature by 0.728 F for each 1.0 F of bay-air TS from the bottom to the top of the drywell. The drywell outer-surface peak heat flux was shifted downward because of the effect of bay-air TS. An equivalent model was evaluated by the nodal-network conduction, convection, and radiation heat-transfer computer program (Thermal System Analysis Program) TSAP. The TSAP results are in good agreement with the CFX-model results, with the difference in results understood based on the approximations of each model

Phase I study of concurrent radiotherapy with TS-1 and vitamin A (TAR therapy) for head and neck cancer

International Nuclear Information System (INIS)

Nakashima, Torahiko; Kuratomi, Yuichiro; Yamamoto, Tomoya; Masuda, Muneyuki; Hirakawa, Naoya; Nakamura, Kazumasa; Shioyama, Yoshiyuki; Umezaki, Toshiro; Komune, Shizuo

2005-01-01

The triple combination of 5-fluorouracil (5-FU), vitamin A and radiation (FAR therapy) has been effectively used to treat head and neck cancer. The biological anti-tumor effect of 5-FU depends on the activity of its metabolizing enzyme, dihydropyrimidine dehydrogenase (DPD). TS-1 is a novel oral DPD inhibitory fluoropyrimidine (DIF). To improve the anti-tumor effect of FAR therapy, we have applied TS-1 in place of 5-FU injection in the combination of Vitamin A and radiation (TAR therapy). In this study, we have examined the appropriate duration of TS-1 medication and the clinical efficacy and safety of TAR therapy. TS-1 was administered orally at a dose of 65 mg/m 2 twice a day. Vitamin A (Retinol Palmitate: 50,000 U/day) was administered intra-musculary on each day of radiation. Radiation was given (1.5∼2 Gy/day: 5 days/week) for 30∼40 Gy. The levels were divided according to the length of TS-1 application as follows: level 1, 2 weeks; level 2, 3 weeks; level 4, 4 weeks. Grade 4 toxicity of anorexia was observed in one case of level 3. We decided that level 2 (3 weeks of TS-1 administration) was the appropriate length of TS-1 application. TAR therapy is a useful concurrent chemo-radiotherapy which might improve the response rate and quality of life (QOL) of patients with head and neck squamous cell carcinoma (HNSCC). (author)

Interstitial lung disease caused by TS-1: a case of long-term drug retention as a fatal adverse reaction.

Science.gov (United States)

Park, Joong-Min; Hwang, In Gyu; Suh, Suk-Won; Chi, Kyong-Choun

2011-12-01

TS-1 is an oral anti-cancer agent for gastric cancer with a high response rate and low toxicity. We report a case of long-term drug retention of TS-1 causing interstitial lung disease (ILD) as a fatal adverse reaction. A 65-year-old woman underwent a total gastrectomy with pathologic confirmation of gastric adenocarcinoma. She received 6 cycles of TS-1 and low-dose cisplatin for post-operative adjuvant chemotherapy followed by single-agent maintenance therapy with TS-1. After 8 months, the patient complained of a productive cough with sputum and mild dyspnea. A pulmonary evaluation revealed diffuse ILD in the lung fields, bilaterally. In spite of discontinuing chemotherapy and the administration of corticosteroids, the pulmonary symptoms did not improve, and the patient died of pulmonary failure. TS-1-induced ILD can be caused by long-term drug retention that alters the lung parenchyma irreversibly, the outcome of which can be life-threatening. Pulmonary evaluation for early detection of disease is recommended.

Theatrical Style and the Work of T.S. Eliot.

Science.gov (United States)

Harris, Warren Meredith

This study examines T.S. Eliot's intentions for the staging of his plays, as revealed in the texts themselves and in related documents. His plays reflect his basically naturalistic conception of the stage environment and the acting; two of the plays, "Sweeney Agonistes," which was unfinished, and "The Family Reunion," demonstrate his inability to…

Diamond-like carbon coatings enhance the hardness and resilience of bearing surfaces for use in joint arthroplasty.

Science.gov (United States)

Roy, M E; Whiteside, L A; Xu, J; Katerberg, B J

2010-04-01

The purpose of this study was to evaluate the potential of a hard diamond-like carbon (DLC) coating to enhance the hardness and resilience of a bearing surface in joint replacement. The greater hardness of a magnesium-stabilized zirconium (Mg-PSZ) substrate was expected to provide a harder coating-substrate composite microhardness than the cobalt-chromium alloy (CoCr) also used in arthroplasty. Three femoral heads of each type (CoCr, Mg-PSZ, DLC-CoCr and DLC-Mg-PSZ) were examined. Baseline (non-coated) and composite coating/substrate hardness was measured by Vickers microhardness tests, while nanoindentation tests measured the hardness and elastic modulus of the DLC coating independent of the Mg-PSZ and CoCr substrates. Non-coated Mg-PSZ heads were considerably harder than non-coated CoCr heads, while DLC coating greatly increased the microhardness of the CoCr and Mg-PSZ substrates. On the nanoscale the non-coated heads were much harder than on the microscale, with CoCr exhibiting twice as much plastic deformation as Mg-PSZ. The mechanical properties of the DLC coatings were not significantly different for both the CoCr and Mg-PSZ substrates, producing similar moduli of resilience and plastic resistance ratios. DLC coatings greatly increased hardness on both the micro and nano levels and significantly improved resilience and resistance to plastic deformation compared with non-coated heads. Because Mg-PSZ allows less plastic deformation than CoCr and provides a greater composite microhardness, DLC-Mg-PSZ will likely be more durable for use as a bearing surface in vivo. Copyright 2009 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

VISIT-TS: A multimedia tool for population studies on tic disorders [version 2; referees: 2 approved

Directory of Open Access Journals (Sweden)

M. Jonathan Vachon

2016-10-01

Full Text Available Population-based assessment of Tourette syndrome (TS and other tic disorders produces a paradox. On one hand, ideally diagnosis of tic disorders requires expert observation. In fact, diagnostic criteria for TS explicitly require expert assessment of tics for a definite diagnosis. On the other hand, large-scale population surveys with expert assessment of every subject are impracticable. True, several published studies have successfully used expert assessment to find tic prevalence in a representative population (e.g. all students in a school district. However, extending these studies to larger populations is daunting. We created a multimedia tool to demonstrate tics to a lay audience, discuss their defining and common attributes, and address features that differentiate tics from other movements and vocalizations. A first version was modified to improve clarity and to include a more diverse group in terms of age and ethnicity. The result is a tool intended for epidemiological research. It may also provide additional benefits, such as more representative minority recruitment for other TS studies and increased community awareness of TS.

Short-lived non-coding transcripts (SLiTs): Clues to regulatory long non-coding RNA.

Science.gov (United States)

Tani, Hidenori

2017-03-22

Whole transcriptome analyses have revealed a large number of novel long non-coding RNAs (lncRNAs). Although the importance of lncRNAs has been documented in previous reports, the biological and physiological functions of lncRNAs remain largely unknown. The role of lncRNAs seems an elusive problem. Here, I propose a clue to the identification of regulatory lncRNAs. The key point is RNA half-life. RNAs with a long half-life (t 1/2 > 4 h) contain a significant proportion of ncRNAs, as well as mRNAs involved in housekeeping functions, whereas RNAs with a short half-life (t 1/2 regulatory ncRNAs and regulatory mRNAs. This novel class of ncRNAs with a short half-life can be categorized as Short-Lived non-coding Transcripts (SLiTs). I consider that SLiTs are likely to be rich in functionally uncharacterized regulatory RNAs. This review describes recent progress in research into SLiTs.

CaTs Lab (CHAOS and Thermal Sciences Laboratory)

Science.gov (United States)

Teate, Anthony A.

2002-01-01

The CHAOS and Thermal Sciences Laboratory (CaTs) at James Madison University evolved into a noteworthy effort to increase minority representation in the sciences and mathematics. Serving ten students and faculty directly, and nearly 50 students indirectly, CaTs, through recruitment efforts, workshops, mentoring programs, tutorial services and research and computational laboratories, fulfilled its intent to initiate an academically enriched research program aimed at strengthening the academic and self-actualization skills of undergraduate students with potential to pursue doctoral study in the sciences. The stated goal of the program was to increase by 5% the number of enrolled mathematics and science students into the program. Success far exceeded the program goals by producing 100% graduation rate of all supported recipients during its tenure, with 30% of the students subsequently in pursuit of graduate degrees. Student retention in the program exceeded 90% and faculty participation exceeded the three members involved in mentoring and tutoring, gaining multi-disciplinary support. Aggressive marketing of the program resulted in several paid summer internships and commitments from NASA and an ongoing relationship with CHROME, a nationally recognized organization which focuses on developing minority students in the sciences and mathematics. Success of the program was only limited by the limited fiscal resources at NASA which resulted in phasing out of the program.

Attentional function and basal forebrain cholinergic neuron morphology during aging in the Ts65Dn mouse model of Down syndrome.

Science.gov (United States)

Powers, Brian E; Velazquez, Ramon; Kelley, Christy M; Ash, Jessica A; Strawderman, Myla S; Alldred, Melissa J; Ginsberg, Stephen D; Mufson, Elliott J; Strupp, Barbara J

2016-12-01

Individuals with Down syndrome (DS) exhibit intellectual disability and develop Alzheimer's disease-like neuropathology during the third decade of life. The Ts65Dn mouse model of DS exhibits key features of both disorders, including impairments in learning, attention and memory, as well as atrophy of basal forebrain cholinergic neurons (BFCNs). The present study evaluated attentional function in relation to BFCN morphology in young (3 months) and middle-aged (12 months) Ts65Dn mice and disomic (2N) controls. Ts65Dn mice exhibited attentional dysfunction at both ages, with greater impairment in older trisomics. Density of BFCNs was significantly lower for Ts65Dn mice independent of age, which may contribute to attentional dysfunction since BFCN density was positively associated with performance on an attention task. BFCN volume decreased with age in 2N but not Ts65Dn mice. Paradoxically, BFCN volume was greater in older trisomic mice, suggestive of a compensatory response. In sum, attentional dysfunction occurred in both young and middle-aged Ts65Dn mice, which may in part reflect reduced density and/or phenotypic alterations in BFCNs.

Temperature-sensitive mutants of influenza A virus. XIV. Production and evaluation of influenza A/Georgia/74-ts-1[E] recombinant viruses in human adults.

Science.gov (United States)

Richman, D D; Murphy, B R; Belshe, R B; Rusten, H M; Chanock, R M; Blacklow, N R; Parrino, T A; Rose, F B; Levine, M M; Caplan, E

1977-08-01

The two temperature-sensitive (ts) lesions present in influenza A/Hong Kong/68-ts-1[E] (H3N2 68) virus were transferred via genetic reassortment to influenza A/Georgia/74 (H3N2 74) wild-type virus. A recombinant clone possessing both ts lesions and the shutoff temperature of 38 C of the Hong Kong/68 ts donor and the two surface antigens of the Georgia/74 wild-type virus was administered to 32 seronegative adult volunteers. Thirty-one volunteers were infected, of whom only five experienced mild afebrile upper respiratory tract illness. The wild-type recipient virus was a cloned population that induced illness in five of six infected volunteers. Therfore, the attenuation exhibited by the Georgia/74-ts-1[E] virus could reasonably be assumed to be due to the acquisition of the two ts-1[E] lesions by the Georgia/74 wild-type virus. The serum and nasal wash antibody responses of the ts-1[E] vaccinees were equivalent to those of the volunteers who received wild-type virus. The two ts lesions present in the Hong Kong/68-ts-1[E] virus have now been transferred three times to a wild-type virus bearing a new hemagglutinin, and in each instance the new ts recombination exhibited a similar, satisfactory level of attenuation and antigenicity for adults. It seems likely that the transfer of the ts-1[E] lesions to any new influenza virus will regularly result in attenuation of a recombinat virus possessing the new surface antigens.

MIS High-Purity Plutonium Oxide Metal Oxidation Product TS707001 (SSR123): Final Report

Energy Technology Data Exchange (ETDEWEB)

Veirs, Douglas Kirk [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Stroud, Mary Ann [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Berg, John M. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Narlesky, Joshua Edward [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Worl, Laura Ann [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Martinez, Max A. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Carillo, Alex [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

2017-08-09

A high-purity plutonium dioxide material from the Material Identification and Surveillance (MIS) Program inventory has been studied with regard to gas generation and corrosion in a storage environment. Sample TS707001 represents process plutonium oxides from several metal oxidation operations as well as impure and scrap plutonium from Hanford that are currently stored in 3013 containers. After calcination to 950°C, the material contained 86.98% plutonium with no major impurities. This study followed over time, the gas pressure of a sample with nominally 0.5 wt% water in a sealed container with an internal volume scaled to 1/500th of the volume of a 3013 container. Gas compositions were measured periodically over a six year period. The maximum observed gas pressure was 138 kPa. The increase over the initial pressure of 80 kPa was primarily due to generation of nitrogen and carbon dioxide gas in the first six months. Hydrogen and oxygen were minor components of the headspace gas. At the completion of the study, the internal components of the sealed container showed signs of corrosion, including pitting.

Emotion of Physiological Signals Classification Based on TS Feature Selection

Institute of Scientific and Technical Information of China (English)

Wang Yujing; Mo Jianlin

2015-01-01

This paper propose a method of TS-MLP about emotion recognition of physiological signal.It can recognize emotion successfully by Tabu search which selects features of emotion’s physiological signals and multilayer perceptron that is used to classify emotion.Simulation shows that it has achieved good emotion classification performance.

Function and structure in phage Qbeta RNA replicase. Association of EF-Tu-Ts with the other enzyme subunits

DEFF Research Database (Denmark)

Blumenthal, T; Young, R A; Brown, S

1976-01-01

alters its quaternary structure: the EF-Tu-Ts cannot be covalently attached to the other enzyme subunits with bifunctional cross-linking reagents in the presence of RNA. This conformational change is not influenced by ionic strength. The addition of Qbeta RNA to the enzyme, does not result in the release...... for one another increases with increasing ionic strength. The enzyme is capable of initiation of RNA synthesis with synthetic templates only when in the low ionic strength conformation. Elongation of initiated polynucleotide chains is not affectedby ionic strength. Addition of Qbeta RNA to the enzyme also...... of EF-Tu-Ts from the other enzyme subunits: whereas free EF-Tu-Ts binds GDP independently of salt concentration, this binding by Qbeta replicase is sensitive to high ionic strength and remains so in the presence of Qbeta RNA. Furthermore, RNA does not allow the release of EF-Ts from EF-Tu by GTP...

Hematopoietic Stem Cells from Ts65Dn Mice Are Deficient in the Repair of DNA Double-Strand Breaks.

Science.gov (United States)

Wang, Yingying; Chang, Jianhui; Shao, Lijian; Feng, Wei; Luo, Yi; Chow, Marie; Du, Wei; Meng, Aimin; Zhou, Daohong

2016-06-01

Down syndrome (DS) is a genetic disorder caused by the presence of an extra partial or whole copy of chromosome 21. In addition to musculoskeletal and neurodevelopmental abnormalities, children with DS exhibit various hematologic disorders and have an increased risk of developing acute lymphoblastic leukemia and acute megakaryocytic leukemia. Using the Ts65Dn mouse model, we investigated bone marrow defects caused by trisomy for 132 orthologs of the genes on human chromosome 21. The results showed that, although the total bone marrow cellularity as well as the frequency of hematopoietic progenitor cells (HPCs) was comparable between Ts65Dn mice and their age-matched euploid wild-type (WT) control littermates, human chromosome 21 trisomy led to a significant reduction in hematopoietic stem cell (HSC) numbers and clonogenic function in Ts65Dn mice. We also found that spontaneous DNA double-strand breaks (DSBs) were significantly increased in HSCs from the Ts65Dn mice, which was correlated with the significant reduction in HSC clonogenic activity compared to those from WT controls. Moreover, analysis of the repair kinetics of radiation-induced DSBs revealed that HSCs from Ts65Dn mice were less proficient in DSB repair than the cells from WT controls. This deficiency was associated with a higher sensitivity of Ts65Dn HSCs to radiation-induced suppression of HSC clonogenic activity than that of euploid HSCs. These findings suggest that an additional copy of genes on human chromosome 21 may selectively impair the ability of HSCs to repair DSBs, which may contribute to DS-associated hematological abnormalities and malignancies.

[Mechanism of Platycarya strobilacea Sieb. et Zucc extract-induced methuosis in human nasopharyngeal carcinoma CNE1 and CNE2 cells].

Science.gov (United States)

Zhu, Jun-Yu; Tu, Wei; Zeng, Chao; Mao, Heng-Xu; DU, Qing-Feng; Cai, Hong-Bing

2017-06-20

To study the effect of Platycarya strobilacea Sieb. et Zucc (PSZ) extract on methuosis of human nasopharyngeal carcinoma CNE1 and CNE2 cells and explore the underlying mechanism. CNE1 and CNE2 cells were treated with 1 mg/mL PSZ extract and the expressions of Rac1 mRNA and Rac1 protein were detected using RT-qPCR and Western blotting, respectively. Results CNE1 and CNE2 cells showed obvious morphological changes typical of methuosis following treatment with PSZ extract characterized by cell merging, accumulation of large cytoplasmic vacuoles, and membrane rupture without obvious changes in the nuclei. PSZ treatment resulted in up-regulated Rac1 mRNA and Rac1 protein expressions in the cells. Application of EHT 1864 obviously blocked the effect of PSZ extract in inducing methuosis in CNE1 and CNE2 cells. PSZ extract can induce methuosis in CNE1 and CNE2 cells by inducing the overexpression of Rac1.

Constitutional equations of thermal stresses of particle-reinforced composite

International Nuclear Information System (INIS)

Asakawa, Atsushi; Noda, Naotake; Tohgo, Keiichiro; Tsuji, Tomoaki.

1994-01-01

Functionally gradient materials (FGM) have been developed as ultrahigh-heat-resistant materials in aircraft, space engineering and nuclear fields. In the heat-resistant FGM which contain particles (ceramics) in the matrix (metal), the matrix will be subjected to plastic deformation, particles will be debonded, and finally cracks will be generated. The constitutive equations of FGM which take into account the damage process and change in temperature are necessary in order to solve these phenomena. In this paper, the constitutive equations of particle-reinforced composites with consideration of the damage process and change in temperature are estimated by the equivalent inclusion method in terms of elastoplasticity. The stress-strain relations and the coefficients of linear thermal expansion of the composites (Al-PSZ and Ti-PSZ) are calculated in ultrahigh temperature. (author)

Modeling of space environment impact on nanostructured materials. General principles

Science.gov (United States)

Voronina, Ekaterina; Novikov, Lev

2016-07-01

In accordance with the resolution of ISO TC20/SC14 WG4/WG6 joint meeting, Technical Specification (TS) 'Modeling of space environment impact on nanostructured materials. General principles' which describes computer simulation methods of space environment impact on nanostructured materials is being prepared. Nanomaterials surpass traditional materials for space applications in many aspects due to their unique properties associated with nanoscale size of their constituents. This superiority in mechanical, thermal, electrical and optical properties will evidently inspire a wide range of applications in the next generation spacecraft intended for the long-term (~15-20 years) operation in near-Earth orbits and the automatic and manned interplanetary missions. Currently, ISO activity on developing standards concerning different issues of nanomaterials manufacturing and applications is high enough. Most such standards are related to production and characterization of nanostructures, however there is no ISO documents concerning nanomaterials behavior in different environmental conditions, including the space environment. The given TS deals with the peculiarities of the space environment impact on nanostructured materials (i.e. materials with structured objects which size in at least one dimension lies within 1-100 nm). The basic purpose of the document is the general description of the methodology of applying computer simulation methods which relate to different space and time scale to modeling processes occurring in nanostructured materials under the space environment impact. This document will emphasize the necessity of applying multiscale simulation approach and present the recommendations for the choice of the most appropriate methods (or a group of methods) for computer modeling of various processes that can occur in nanostructured materials under the influence of different space environment components. In addition, TS includes the description of possible

TS-05: 150 lines of java with high architectural complexity

DEFF Research Database (Denmark)

Christensen, Henrik Bærbak

2005-01-01

In the short time span available in a software architecture course, it is difficult to find a software system that is both interesting from an architectural perspective and so small that it does not overwhelm the students.We present TS-05 which is a bare 150 line Java "toy-system" that never...

Experiments in a boundary layer subjected to free stream turbulence. Part 2: The role of TS waves in the transition process

International Nuclear Information System (INIS)

Boiko, A.V.; Westin, K.J.A.; Klingmann, B.G.B.; Kozlov, V.V.; Alfredsson, P.H.

1993-12-01

The natural occurrence of Tollmien-Schlichting (TS) waves has so far only been observed in boundary layers subjected to moderate levels of free stream turbulence (Tu <1%), due to the difficulty in detecting small-amplitude waves in highly perturbed boundary layers. By introducing controlled oscillations with a vibrating ribbon, it is possible to study small amplitude waves using phase-selective filtering techniques. In the present work, the effect of TS-waves on the transition is studied at Tu = 1.5%. It is demonstrated that TS-waves can exist and develop in a similar way as in an undisturbed boundary layer. It is also found that TS-waves with quite small amplitudes are involved in nonlinear interactions which lead to a regeneration of TS-waves in the whole unstable frequency band. This results in a significant increase in the number of turbulent spots, which promote the onset of turbulence. 28 refs

Ceramic Technology Project data base: September 1992 summary report

Energy Technology Data Exchange (ETDEWEB)

Keyes, B.L.P.

1993-06-01

Data presented in this report represent an intense effort to improve processing methods, testing methods, and general mechanical properties (rupture modulus, tensile, creep, stress-rupture, dynamic and cyclic fatigue, fracture toughness) of candidate ceramics for use in advanced heat engines. This work was performed by many facilities and represents only a small part of the data generated by the Ceramic Technology Project (CTP) since 1986. Materials discussed include GTE PY6, GN-10, NT-154, NT-164, SN-260, SN-251, SN-252, AY6, silicon nitride combined with rare-earth oxides, Y-TZP, ZTA, NC-433, NT-230, Hexoloy SA, MgO-PSZ-to-MgO-PSZ joints, MgO-PSZ-to-cast iron, and a few whisker/fiber-reinforced ceramics. Information in this report was taken from the project`s semiannual and bimonthly progress reports and from final reports summarizing the results of individual studies. Test results are presented in tabular form and in graphs. All data, including test rig descriptions and material characterizations, are stored in the CTP data base and are available to all project participants on request. The objective of this report is to make available the test results from these studies but not to draw conclusions from those data.

Microstructural development in physical vapour-deposited partially stabilized zirconia thermal barrier coatings

Energy Technology Data Exchange (ETDEWEB)

Sohn, Y. H. (Center for Intelligent Processing of Materials, Worcester Polytechnic Institute, 100 Institute Road, Worcester, MA 01609-2280 (United States)); Biederman, R.R. (Center for Intelligent Processing of Materials, Worcester Polytechnic Institute, 100 Institute Road, Worcester, MA 01609-2280 (United States)); Sisson, R.D. Jr. (Center for Intelligent Processing of Materials, Worcester Polytechnic Institute, 100 Institute Road, Worcester, MA 01609-2280 (United States))

1994-10-01

The effects of processing parameters of physical vapour deposition on the microstructure of partially stabilized zirconia (PSZ) thermal barrier coatings have been experimentally investigated. Emphasis has been placed on the crystallographic texture of the PSZ coatings and the microstructure of the top surface of the PSZ coatings as well as the metal-ceramic interface. The variations in the deposition chamber temperature, substrate thickness, substrate rotation and vapour incidence angle resulted in the observation of significant differences in the crystallographic texture and microstructure of the PSZ coatings. ((orig.))

Elongation factor Ts directly facilitates the formation and disassembly of the Escherichia coli elongation factor Tu·GTP·aminoacyl-tRNA ternary complex.

Science.gov (United States)

Burnett, Benjamin J; Altman, Roger B; Ferrao, Ryan; Alejo, Jose L; Kaur, Navdep; Kanji, Joshua; Blanchard, Scott C

2013-05-10

Aminoacyl-tRNA (aa-tRNA) enters the ribosome in a ternary complex with the G-protein elongation factor Tu (EF-Tu) and GTP. EF-Tu·GTP·aa-tRNA ternary complex formation and decay rates are accelerated in the presence of the nucleotide exchange factor elongation factor Ts (EF-Ts). EF-Ts directly facilitates the formation and disassociation of ternary complex. This system demonstrates a novel function of EF-Ts. Aminoacyl-tRNA enters the translating ribosome in a ternary complex with elongation factor Tu (EF-Tu) and GTP. Here, we describe bulk steady state and pre-steady state fluorescence methods that enabled us to quantitatively explore the kinetic features of Escherichia coli ternary complex formation and decay. The data obtained suggest that both processes are controlled by a nucleotide-dependent, rate-determining conformational change in EF-Tu. Unexpectedly, we found that this conformational change is accelerated by elongation factor Ts (EF-Ts), the guanosine nucleotide exchange factor for EF-Tu. Notably, EF-Ts attenuates the affinity of EF-Tu for GTP and destabilizes ternary complex in the presence of non-hydrolyzable GTP analogs. These results suggest that EF-Ts serves an unanticipated role in the cell of actively regulating the abundance and stability of ternary complex in a manner that contributes to rapid and faithful protein synthesis.

Tensile strength/yield strength (TS/YS) ratios of high-strength steel (HSS) reinforcing bars

Science.gov (United States)

Tavio, Anggraini, Retno; Raka, I. Gede Putu; Agustiar

2018-05-01

The building codes such as American Concrete Institute (ACI) 318M-14 and Standard National Indonesia (SNI) 2847:2013 require that the ratio of tensile strength (TS) and yield strength (YS) should not less than 1.25. The requirement is based on the assumption that a capability of a structural member to develop inelastic rotation capacity is a function of the length of the yield region. This paper reports an investigation on various steel grades, namely Grades 420, 550, 650, and 700 MPa, to examine the impact of different TS/YS ratios if it is less or greater than the required value. Grades 550, 650, and 700 MPa were purposely selected with the intention to examine if these higher grades are still promising to be implemented in special structural systems since they are prohibited by the building codes for longitudinal reinforcement, whereas Grade 420 MPa bars are the maximum limit of yield strength of reinforcing bars that is allowable for longitudinal reinforcement of special structural systems. Tensile tests of these steel samples were conducted under displacement controlled mode to capture the complete stress-strain curves and particularly the post-yield response of the steel bars. From the study, it can be concluded that Grade 420 performed higher TS/YS ratios and they were able to reach up to more than 1.25. However, the High Strength Still (HSS) bars (Grades 550, 600, and 700 MPa) resulted in lower TS/YS ratios (less than 1.25) compared with those of Grade 420 MPa.

Sodium Lauryl Sulfate Competitively Interacts with HPMC-AS and Consequently Reduces Oral Bioavailability of Posaconazole/HPMC-AS Amorphous Solid Dispersion.

Science.gov (United States)

Chen, Yuejie; Wang, Shujing; Wang, Shan; Liu, Chengyu; Su, Ching; Hageman, Michael; Hussain, Munir; Haskell, Roy; Stefanski, Kevin; Qian, Feng

2016-08-01

Sodium lauryl sulfate (SLS), as an effective surfactant, is often used as a solubilizer and/or wetting agent in various dosage forms for the purpose of improving the solubility and dissolution of lipophilic, poorly water-soluble drugs. This study aims to understand the impact of SLS on the solution behavior and bioavailability of hypromellose acetate succinate (HPMC-AS)-based posaconazole (PSZ) ASDs, and to identify the underlying mechanisms governing the optimal oral bioavailability of ASDs when surfactants such as SLS are used in combination. Fluorescence spectroscopy and optical microscopy showed that "oil-out" or "liquid-liquid phase separation (LLPS)" occurred in the supersaturated PSZ solution once drug concentration surpassed ∼12 μg/mL, which caused the formation of drug-rich oily droplets with initial size of ∼300-400 nm. Although FT-IR study demonstrated the existence of specific interactions between PSZ and HPMC-AS in the solid state, predissolved HPMC-AS was unable to delay LLPS of the supersaturated PSZ solution and PSZ-rich amorphous precipitates with ∼16-18% HPMC-AS were formed within 10 min. The coprecipitated HPMC-AS was found to be able to significantly delay the crystallization of PSZ in the PSZ-rich amorphous phase from less than 10 min to more than 4 h, yet coexistent SLS was able to negate this crystallization inhibition effect of HPMC-AS in the PSZ-rich amorphous precipitates and cause fast PSZ crystallization within 30 min. 2D-NOESY and the CMC/CAC results demonstrated that SLS could assemble around HPMC-AS and competitively interact with HPMC-AS in the solution, thus prevent HPMC-AS from acting as an effective crystallization inhibitor. In a crossover dog PK study, this finding was found to be correlating well with the in vivo bioavailability of PSZ ASDs formulated with or without SLS. The SLS containing PSZ ASD formulation demonstrated an in vivo bioavailability ∼30% of that without SLS, despite the apparently better in vitro

PFCRT and DHFR-TS Sequences for Monitoring Drug Resistance in ...

African Journals Online (AJOL)

Erah

from falciparum malaria isolates collected in Adzopé City, Côte d'Ivoire in 2007. Methods: Blood ... performed using specific primers of pfcrt and dhfr-ts. During the study .... The following mixture was prepared to a final volume of 50 ..... following the withdrawal of these anti- malarials as ... Malaria vaccines in Africa. Acta Trop.

Impaired retrieval processes evident during visual working memory in schizophrenia

Directory of Open Access Journals (Sweden)

Peter A. Lynn

2016-09-01

Full Text Available Prominent working memory (WM deficits have been observed in people with schizophrenia (PSZ across multiple sensory modalities, including the visuospatial realm. Electrophysiological abnormalities noted during early visual processing as well as later cognitive functions in PSZ may underlie deficiencies in WM ability, though the mechanisms linking behavior to neural responses are not well understood. WM dysfunction has also been observed in biological relatives of PSZ (REL and therefore may be a manifestation of genetic liability for the disorder. We administered a delayed response visuospatial WM task to 23 PSZ, 30 of their REL, and 37 healthy controls (CTRL to better understand the contributions of neural abnormalities to WM performance deficits associated with schizophrenia. PSZ performed more poorly on the WM task and failed to effectively process distractor stimuli as well as CTRL and REL. N1 electrophysiological responses to probes during retrieval differentiated the type and locations of stimuli presented during encoding in CTRL. Retrieval N1 responses in PSZ, however, failed to do so, while retrieval responses in REL showed more pronounced differentiation of stimulus features during encoding. Furthermore, neural responses during retrieval predicted behavioral performance in PSZ and REL, but not CTRL. These results suggest that retrieval processes are particularly important to efficient visuospatial WM function in PSZ and REL, and support further investigation of WM retrieval as a potential target for improving overall WM function through clinical intervention.

Automotive standard ISO/TS 16949 as a quality determinant

Directory of Open Access Journals (Sweden)

Joanna Rosak-Szyrocka

2016-03-01

Full Text Available The main aim of this paper is to present the standard ISO/TS 16949. In the modern world of competition, quality is one of the most important factors. Modern organizations should gamble on quality, regardless of the type of business, because it is the basic form of running a business effectively. It is not only a factor of market success, but also an indication of organizational culture.

Diagnosis of initial changes in patients suffering from rheumatoid arthritis. A comparison between low-field magnetic resonance imaging, 3-phase bone scintigraphy and conventional X-ray

International Nuclear Information System (INIS)

Hoepfner, S.; Dresel, S.; Weiss, M.; Hahn, K.; Treitl, M.; Krolak, C.; Becker-Gaab, C.; Schattenkirchner, M.

2002-01-01

Besides conventional X-rays, in the diagnostic work up of initial changes in patients suffering from rheumatoid arthritis (RA), 3-phase bone scintigraphy (3P-Sz) is as well established as magnetic resonance imaging (MRI). The aim of this study was to compare the diagnostic value of the newly developed low field MRI with the proven methods X-rays and 3P-Sz. Methods: 65 patients (47f, 18m; 20-86 yrs) were studied on a one day protocol with 3P-Sz (550 MBq Tc-99m DPD), MRI and X-rays of the hands. Images were visually analysed by two blinded nuclear medicine physicians and radiologists and classified as a) RA-typical, b) inflammatory, non-RA-typical and c) non inflammatory changes. All methods were compared to 3P-Sz as golden standard. Results: In comparison to 3P-Sz, low field MRI presents with almost equal sensitivity and specificity in rheumatoid-typical and inflammatory changes. Conventional X-rays revealed in arthritis-typical changes as well as in inflammatory changes a significantly lower sensitivity and also a lower negative predictive value while specificity equals the one of MRI. Quantitative analysis of 3P-Sz using ROI-technique unveiled significantly higher values in patients with rheumatoid arthritis than in those with no inflammatory changes. Conclusion: MRI represents an equally sensitive method in the initial diagnosis of rheumatoid-typical and inflammatory changes in the region of the hands as compared to the 3P-Sz. Besides the basic diagnosis with conventional X-rays, 3P-Sz is still the recommended method of choice to evaluate the whole body when RA is suspected. Additionally, quantitative analysis of the 3P-Sz using the ROI technique in the region of the hands reveals statistically significant results and should therefore be taken into account in the assessment of inflammatory changes. (orig.) [de

ERCC1 and TS Expression as Prognostic and Predictive Biomarkers in Metastatic Colon Cancer.

Directory of Open Access Journals (Sweden)

Michel B Choueiri

Full Text Available In patients with metastatic colon cancer, response to first line chemotherapy is a strong predictor of overall survival (OS. Currently, oncologists lack diagnostic tests to determine which chemotherapy regimen offers the greatest chance for response in an individual patient. Here we present the results of gene expression analysis for two genes, ERCC1 and TS, measured with the commercially available ResponseDX: Colon assay (Response Genetics, Los Angeles, CA in 41 patients with de novo metastatic colon cancer diagnosed between July 2008 and August 2013 at the University of California, San Diego. In addition ERCC1 and TS expression levels as determined by RNAseq and survival data for patients in TCGA were downloaded from the TCGA data portal. We found that patients with low expression of ERCC1 (n = 33 had significantly longer median OS (36.0 vs. 10.1 mo, HR 0.29, 95% CI .095 to .84, log-rank p = 9.0x10-6 and median time to treatment to failure (TTF following first line chemotherapy (14.1 vs. 2.4 mo, HR 0.17, 95% CI 0.048 to 0.58, log-rank p = 5.3x10-4 relative to those with high expression (n = 4. After accounting for the covariates age, sex, tumor grade and ECOG performance status in a Cox proportional hazard model the association of low ERCC1 with longer OS (HR 0.18, 95% CI 0.14 to 0.26, p = 0.0448 and TTF (HR 0.16, 95% CI 0.14 to 0.21, p = 0.0053 remained significant. Patients with low TS expression (n = 29 had significantly longer median OS (36.0 vs. 14.8 mo, HR 0.25, 95% CI 0.074 to 0.82, log-rank p = 0.022 relative to those with high expression (n = 12. The combined low expression of ERCC1/TS was predictive of response in patients treated with FOLFOX (40% vs. 91%, RR 2.3, Fisher's exact test p = 0.03, n = 27, but not with FOLFIRI (71% vs. 71%, RR 1.0, Fisher's exact test p = 1, n = 14. Overall, these findings suggest that measurement of ERCC1 and TS expression has potential clinical utility in managing patients with metastatic colorectal

Synthesis of mesh-shaped calcia partially stabilized zirconia using eggshell membrane template as filler composite

Directory of Open Access Journals (Sweden)

Gema Gempita

2017-08-01

Full Text Available This experiment was conducted experimentally to synthesize Calcia Partially Stabilized Zirconia (Ca-PSZ by sol-gel method using eggshell membrane template as a composite filler. The eggshell membrane was used to produce a mesh shaped structure, which hopefully can improve the mechanical properties of the composite. Ca-PSZ filler was synthesized from ZrOCl2 precursor and Ca(NO32 stabilizer with a 24 hours immersion time. Ca-PSZ of synthesis then mixed with the resin matrix to test its composite hardness. The EDS characterization results suggested that the sample contained elements of zirconia, calcium, and oxygen. Whereas, the XRD characterization identified that crystal structures that formed in the sample were nano scale tetragonal. Characterization of SEM showed Ca-PSZ with mesh structured. The average composite hardness value was 15.79 VHN. The composites with Ca-PSZ-synthesized filler could be prepared and its hardness value was higher than the composite with Ca-PSZ filler in spherical particles, but the hardness was still below the composite on the market.

Long-term stability and properties of zirconia ceramics for heavy duty diesel engine components

Science.gov (United States)

Larsen, D. C.; Adams, J. W.

1985-01-01

Physical, mechanical, and thermal properties of commercially available transformation-toughened zirconia are measured. Behavior is related to the material microstructure and phase assemblage. The stability of the materials is assessed after long-term exposure appropriate for diesel engine application. Properties measured included flexure strength, elastic modulus, fracture toughness, creep, thermal shock, thermal expansion, internal friction, and thermal diffusivity. Stability is assessed by measuring the residual property after 1000 hr/1000C static exposure. Additionally static fatigue and thermal fatigue testing is performed. Both yttria-stabilized and magnesia-stabilized materials are compared and contrasted. The major limitations of these materials are short term loss of properties with increasing temperature as the metastable tetragonal phase becomes more stable. Fine grain yttria-stabilized material (TZP) is higher strength and has a more stable microstructure with respect to overaging phenomena. The long-term limitation of Y-TZP is excessive creep deformation. Magnesia-stabilized PSZ has relatively poor stability at elevated temperature. Overaging, decomposition, and/or destabilization effects are observed. The major limitation of Mg-PSZ is controlling unwanted phase changes at elevated temperature.

Primary early correction of tetralogy of Fallot irrespective of age.

Science.gov (United States)

Kantorova, Andrea; Zbieranek, Kai; Sauer, Henning; Lilje, Christian; Haun, Christoph; Hraska, Viktor

2008-04-01

The policy of early repair of patients with tetralogy of Fallot, irrespective of age, as opposed to initial palliation with a shunt, remains controversial. The aim of our study was to analyze the midterm outcome of primary early correction of tetralogy of Fallot. Between 1996 and 2005, a total of 61 consecutive patients less than 6 months of age underwent primary correction of tetralogy of Fallot in two institutions. The median age at surgery was 3.3 months, and 27 patients (44%) were younger than 3 months of age, including 12 (20%) newborns. We analyzed the patients in 2 groups: those younger than 3 months of age, and those aged between 3 and 6 months. There was one early (1.6%), and one late death. Actuarial survival was 98.4%, 96.7%, 96.7% at 1, 5, and 10 years respectively, with a median follow up of 4.5 years. There was no difference in survival, bypass time, lengths of ventilation, and hospital stay between the groups. A transjunctional patch was placed significantly more often in the patients younger than 3 months (p = 0.039), with no adverse effect on survival and morbidity during the follow-up. Freedom from reoperation was 98.2%, 92.2%, and 83% at 1, 5, and 10 years respectively, with no difference between the groups. Elective primary repair of tetralogy of Fallot in asymptomatic patients is delayed beyond 3 months of age. In symptomatic patients, primary repair of tetralogy of Fallot is performed irrespective of age, weight and preoperative state. This approach is safe, and provides an excellent midterm outcome with acceptable morbidity and rates of reintervention. The long-term benefits of this approach must be established by careful follow-up, with particular emphasis on arrhythmias, right ventricular function, and exercise performance.

A highly Conserved Aspartic Acid Residue of the Chitosanase from Bacillus Sp. TS Is Involved in the Substrate Binding.

Science.gov (United States)

Zhou, Zhanping; Zhao, Shuangzhi; Liu, Yang; Chang, Zhengying; Ma, Yanhe; Li, Jian; Song, Jiangning

2016-11-01

The chitosanase from Bacillus sp. TS (CsnTS) is an enzyme belonging to the glycoside hydrolase family 8. The sequence of CsnTS shares 98 % identity with the chitosanase from Bacillus sp. K17. Crystallography analysis and site-direct mutagenesis of the chitosanase from Bacillus sp. K17 identified the important residues involved in the catalytic interaction and substrate binding. However, despite progress in understanding the catalytic mechanism of the chitosanase from the family GH8, the functional roles of some residues that are highly conserved throughout this family have not been fully elucidated. This study focused on one of these residues, i.e., the aspartic acid residue at position 318. We found that apart from asparagine, mutation of Asp318 resulted in significant loss of enzyme activity. In-depth investigations showed that mutation of this residue not only impaired enzymatic activity but also affected substrate binding. Taken together, our results showed that Asp318 plays an important role in CsnTS activity.

REAC/TS Radiation Accident Registry: An Overview

Energy Technology Data Exchange (ETDEWEB)

Doran M. Christensen, DO, REAC/TS Associate Director and Staff Physician Becky Murdock, REAC/TS Registry and Health Physics Technician

2012-12-12

Over the past four years, REAC/TS has presented a number of case reports from its Radiation Accident Registry. Victims of radiological or nuclear incidents must meet certain dose criteria for an incident to be categorized as an “accident” and be included in the registry. Although the greatest numbers of “accidents” in the United States that have been entered into the registry involve radiation devices, the greater percentage of serious accidents have involved sealed sources of one kind or another. But if one looks at the kinds of accident scenarios that have resulted in extreme consequence, i.e., death, the greater share of deaths has occurred in medical settings.

The structural representation and properties of mutually incommensurate composite crystal (BiS)xTS2 (T=Ti, V, Nb and Ta)

International Nuclear Information System (INIS)

Gotoh, Y.; Fujihisa, H.; Takeya, S.; Yamaguchi, I.

2006-01-01

The structural representation of mutually incommensurate composite crystal, (BiS) x TS 2 (T=Ti, V, Nb and Ta), with layered substructures has been described by superspace group approach. The incommensurate composite structures of (BiS) x TS 2 have been successfully characterized by the single-crystal X-ray-diffraction method. Temperature dependences of in-plane electrical resistivity of single composite crystals of (BiS) x TS 2 have been obtained by a standard d.c. four probe method in the range of 1.7-300 K. It has been found that the electronic transport properties of (BiS) x TS 2 compounds show metallic behavior below room temperature. (copyright 2006 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (Abstract Copyright [2006], Wiley Periodicals, Inc.)

Effects of CO2 laser irradiation on the wettability and human skin fibroblast cell response of magnesia partially stabilised zirconia

International Nuclear Information System (INIS)

Hao, L.; Lawrence, J.

2003-01-01

Human skin fibroblast cells in vitro responses on the surface of a bioinert zirconia ceramic partially stabilised with magnesia partially stabilised zirconia (MgO-PSZ) bioinert ceramic before and after CO 2 laser treatment were investigated to find the interrelationship between the cell adhesion, wettability and laser parameters. Contact angle, θ, measurements of a set of test liquids were a clear indication that surface treatment of the MgO-PSZ with a CO 2 laser brought about a reduction in θ, indicating that the wettability of the MgO-PSZ had been enhanced. A relationship was found between the wettability and the microstructure of the MgO-PSZ surface and laser processing parameters. It was subsequently deduced that the factors active in causing the observed modification in the wettability of the MgO-PSZ were the increases in the surface O 2 content and the polar component of the surface energy, γ sv p , the latter resulting from surface melting and resolidification. Moreover, the investigation into the human skin fibroblast cell response revealed that the CO 2 laser treatment of the MgO-PSZ had resulted in a surface favourable for cell adhesion, as the extent of cell attachment and adhesion on the MgO-PSZ surface was enhanced depending on laser parameters. Such an improvement in cell adhesion, which could be greatly beneficial to developing enhanced bonding at the tissue and implant interface, was influenced by the surface properties of the modified MgO-PSZ, particular wettability

Effects of CO{sub 2} laser irradiation on the wettability and human skin fibroblast cell response of magnesia partially stabilised zirconia

Energy Technology Data Exchange (ETDEWEB)

Hao, L.; Lawrence, J

2003-10-15

Human skin fibroblast cells in vitro responses on the surface of a bioinert zirconia ceramic partially stabilised with magnesia partially stabilised zirconia (MgO-PSZ) bioinert ceramic before and after CO{sub 2} laser treatment were investigated to find the interrelationship between the cell adhesion, wettability and laser parameters. Contact angle, {theta}, measurements of a set of test liquids were a clear indication that surface treatment of the MgO-PSZ with a CO{sub 2} laser brought about a reduction in {theta}, indicating that the wettability of the MgO-PSZ had been enhanced. A relationship was found between the wettability and the microstructure of the MgO-PSZ surface and laser processing parameters. It was subsequently deduced that the factors active in causing the observed modification in the wettability of the MgO-PSZ were the increases in the surface O{sub 2} content and the polar component of the surface energy, {gamma}{sub sv}{sup p}, the latter resulting from surface melting and resolidification. Moreover, the investigation into the human skin fibroblast cell response revealed that the CO{sub 2} laser treatment of the MgO-PSZ had resulted in a surface favourable for cell adhesion, as the extent of cell attachment and adhesion on the MgO-PSZ surface was enhanced depending on laser parameters. Such an improvement in cell adhesion, which could be greatly beneficial to developing enhanced bonding at the tissue and implant interface, was influenced by the surface properties of the modified MgO-PSZ, particular wettability.

La grossesse chez l'adolescente à l'hôpital de Tsévié (Togo ...

African Journals Online (AJOL)

Objectif : Décrire le profil des grossesses chez l'adolescente à l'hôpital de Tsévié (Togo). Matériel et méthode : Il s'agissait d'une étude descriptive analytique portant sur les dossiers des parturientes âgées de 10 à 19 ans reçues à l'hôpital de Tsévié entre janvier 2011 et juin 2012. Résultats : Au cours de cette période, 180 ...

Coordination and collaboration between National Regulators for the Safety and Security of International Shipments of Radioactive Materials

International Nuclear Information System (INIS)

Whittingham, Stephen

2016-01-01

The safety record of transporting radioactive material is remarkable; globally with tens of millions of packages transported; each year with approximately 2-3% is related to the nuclear industry. Much of this success is due to the ongoing commitment made by the IAEA and its Member States to maintain over the past 50 years the prescriptive regulations for the transport of radioactive material (TS-R-1) and its associated guidance documents. TS-R-1 is by far the most popular IAEA document in terms of downloads and sales with some Member States adopting them directly into their domestic legal framework whilst others adopt them due to all of the TS-R-1 requirements being incorporated into the UN Model Regulations

18 CFR 3a.71 - Accountability for classified material.

Science.gov (United States)

2010-04-01

... numbers assigned to top secret material will be separate from the sequence for other classified material... central control registry in calendar year 1969. TS 1006—Sixth Top Secret document controlled by the... control registry when the document is transferred. (e) For Top Secret documents only, an access register...

Les coûts du diabète sur 10 ans au Canada : intégration des coûts en soins de santé imputables au diabète à un modèle de prédiction de son incidence

Directory of Open Access Journals (Sweden)

Anja Bilandzic

2017-01-01

Full Text Available Introduction : Notre objectif était d’estimer les coûts de santé directs liés au traitement du diabète au Canada sur 10 ans, à l’aide de données de sondages nationaux et d’un outil de prévision du risque de diabète, ainsi que les coûts par personne. Méthodologie : Nous avons utilisé le Diabetes Population Risk Tool pour estimer le nombre de nouveaux cas de diabète chez les personnes âgées de 20 ans et plus sur 10 ans (jusqu'en 2022 à l’aide des données de 2011 et de 2012 de l’Enquête sur la santé dans les collectivités canadiennes. Nous avons évalué les coûts liés au diabète à partir d’une étude de cohorte faisant appel à l’appariement par score de propension, en utilisant la base de données sur le diabète de l’Ontario ainsi que d’autres données administratives. Nous avons calculé les coûts totaux en utilisant les coûts associés aux nouveaux cas, en tenant compte du sexe, de l’année du diagnostic et des taux de mortalité annuels dus à la maladie. Résultats : D'après nos calculs, le risque de développer le diabète sur 10 ans s’élevait pour la population canadienne en 2011-2012 à 9,98 %, soit 2,16 millions de nouveaux cas. Les coûts totaux en soins de santé imputables au diabète pendant cette période sont de 15,36 milliards (7,55 milliards pour les femmes et 7,81 milliards pour les hommes. Ce sont les hospitalisations de courte durée qui constituent la majeure partie de ces coûts (43,2 %. Des interventions menées au sein de la population entraînant une perte de poids de 5 % au sein de la population permettraient de réduire les coûts des soins de santé de 2,03 milliards de dollars. Une réduction du risque de 30 % obtenue grâce à des interventions auprès des personnes à plus haut risque de développer le diabète (c.-à-d. les 10 % au sommet du groupe à risque le plus élevé entraînerait des économies de l’ordrede 1,48 million de dollars. Conclusion : D'ici 2022

TS gene polymorphisms are not good markers of response to 5-FU therapy in stage III colon cancer patients.

Science.gov (United States)

Fariña-Sarasqueta, A; Gosens, M J E M; Moerland, E; van Lijnschoten, I; Lemmens, V E P P; Slooter, G D; Rutten, H J T; van den Brule, Adriaan J C

2011-08-01

Although the predictive and prognostic value of thymidylate synthase (TS) expression and gene polymorphism in colon cancer has been widely studied, the results are inconclusive probably because of methodological differences. With this study, we aimed to elucidate the role of TS gene polymorphisms genotyping in therapy response in stage III colon carcinoma patients treated with 5-FU adjuvant chemotherapy. 251 patients diagnosed with stage III colon carcinoma treated with surgery followed by 5-FU based adjuvant therapy were selected. The variable number of tandem repeats (VNTR) and the single nucleotide polymorphism (SNP) in the 5'untranslated region of the TS gene were genotyped. There was a positive association between tumor T stage and the VNTR genotypes (p = 0.05). In both univariate and multivariate survival analysis no effects of the studied polymorphisms on survival were found. However, there was an association between both polymorphisms and age. Among patients younger than 60 years, the patients homozygous for 2R seemed to have a better overall survival, whereas among the patients older than 67 this longer survival was seen by the carriers of other genotypes. We conclude that the TS VNTR and SNP do not predict response to 5-FU therapy in patients with stage III colon carcinoma. However, age appears to modify the effects of TS polymorphisms on survival.

The E-learning Cabaret: do's and don'ts in E-Learning Design

NARCIS (Netherlands)

Westera, Wim

2009-01-01

Westera, W. (2006). The E-Learning Cabaret: do's and don'ts in E-Learning Design. Book of Abstracts, 12th International Conference on Technology Supported Learning & Teaching, Online Educa Berlin (pp. 169-171). November, 29-December, 1, 2006, Berlin, Germany: ICWE-GmbH.

An eigenstrain approach to predict phase transformation and self-accommodation in partially stabilized zirconia

International Nuclear Information System (INIS)

Hensl, Th.; Mühlich, U.; Budnitzki, M.; Kuna, M.

2015-01-01

Highlights: • Analytical model to predict phase transformation in PSZ is developed. • Analytical model to predict number of twins in monoclinic inclusions in PSZ. • Models consider inclusions size, shape, temperature, remote loading and surface energy. - Abstract: This work focuses on micromechanical modeling of the tetragonal to monoclinic phase transformation (t–m transformation) in partially stabilized zirconia (PSZ). Tetragonal particles dispersed in a cubic matrix may transform into the monoclinic phase under sufficiently high mechanical loading or if the material is cooled down below a critical temperature. This phase transformation is supposed to be responsible for the so called transformation toughening effect of PSZ. The transformation is usually accompanied by a self-accommodation process, which reduces the occurring eigenstresses in the surrounding matrix. The influences of particle size and geometry, chemical driving force, temperature, surface energy and remote loading on the t–m transformation are estimated by a thermostatic approach. We assume, that transformations occur, once the Gibbs free energy of the transformed equilibrium state is lower than that of the untransformed reference state. To obtain an analytical solution, the microstructure is modeled as an inclusion of rectangular cross section, restrained by an infinite elastic matrix, under plane strain conditions. The developed model for phase transformation captures the well-known size and temperature dependencies. Furthermore, it indicates a significant influence of the particle geometry, that large aspect ratios of the inclusion’s cross section lower the trigger stress for phase transformation

Field Support System (FS-AID) and Working Capital Fund Tracking System (WCF-TS)

Data.gov (United States)

US Agency for International Development — The Field Support System (FS-AID) and Working Capital Fund Tracking System (WCF-TS) are two modules of a single data management system that share common tables and...

ISO/TS 16949 system in quality aspect

Directory of Open Access Journals (Sweden)

Joanna Rosak-Szyrocka

2014-12-01

Full Text Available In the automotive industry the use of modern technology and provision of the highest quality product and related services is the most important element of rivalry between global corporations and motorcycles. In a competitive struggle for the recognition of its brand in the automotive market global organizations continuously raise the requirements for quality management systems, so that the finished product meets all the standards in terms of safety, quality and satisfying the ever-growing needs of customers - present and future drivers and passengers of cars. ISO/TS 16949 quality management system is presented in the paper. A framework for customer specific requirement as well as preventing problems is shown.

Protein dynamics associated with failed and rescued learning in the Ts65Dn mouse model of Down syndrome.

Directory of Open Access Journals (Sweden)

Md Mahiuddin Ahmed

Full Text Available Down syndrome (DS is caused by an extra copy of human chromosome 21 (Hsa21. Although it is the most common genetic cause of intellectual disability (ID, there are, as yet, no effective pharmacotherapies. The Ts65Dn mouse model of DS is trisomic for orthologs of ∼55% of Hsa21 classical protein coding genes. These mice display many features relevant to those seen in DS, including deficits in learning and memory (L/M tasks requiring a functional hippocampus. Recently, the N-methyl-D-aspartate (NMDA receptor antagonist, memantine, was shown to rescue performance of the Ts65Dn in several L/M tasks. These studies, however, have not been accompanied by molecular analyses. In previous work, we described changes in protein expression induced in hippocampus and cortex in control mice after exposure to context fear conditioning (CFC, with and without memantine treatment. Here, we extend this analysis to Ts65Dn mice, measuring levels of 85 proteins/protein modifications, including components of MAP kinase and MTOR pathways, and subunits of NMDA receptors, in cortex and hippocampus of Ts65Dn mice after failed learning in CFC and after learning was rescued by memantine. We show that, compared with wild type littermate controls, (i of the dynamic responses seen in control mice in normal learning, >40% also occur in Ts65Dn in failed learning or are compensated by baseline abnormalities, and thus are considered necessary but not sufficient for successful learning, and (ii treatment with memantine does not in general normalize the initial protein levels but instead induces direct and indirect responses in approximately half the proteins measured and results in normalization of the endpoint protein levels. Together, these datasets provide a first view of the complexities associated with pharmacological rescue of learning in the Ts65Dn. Extending such studies to additional drugs and mouse models of DS will aid in identifying pharmacotherapies for effective

Progress on MOD/RABiTS{sup TM} 2G HTS wire

Energy Technology Data Exchange (ETDEWEB)

Rupich, M.W.; Zhang, W.; Li, X.; Kodenkandath, T.; Verebelyi, D.T.; Schoop, U.; Thieme, C.; Teplitsky, M.; Lynch, J.; Nguyen, N.; Siegal, E.; Scudiere, J.; Maroni, V.; Venkataraman, K.; Miller, D.; Holesinger, T.G

2004-10-01

The development of the second generation (2G) high temperature superconducting wire has advanced beyond initial laboratory demonstrations and is now focused on developing and testing high critical current conductor designs required for commercial applications. The approach pursued at American Superconductor for 2G wire manufacturing is based on the combination of the RABiTS{sup TM} substrate-buffer technology with metal organic deposition (MOD) of the YBCO layer. This MOD/RABiTS{sup TM} approach has been demonstrated in 10 m lengths with critical currents of up to 184 A/cm-width ({approx}2.3 MA/cm{sup 2}) and in short length with critical currents of up to 270 A/cm-width ({approx}3.4 MA/cm{sup 2}). In addition to a high critical current, the superconducting wire must also meet stringent mechanical and electrical stability requirements that vary by application. Commercially viable architectures designed to meet these specifications have been fabricated and tested. Wires manufactured by this process have been successfully tested in prototype cable and coil applications.

Memory H ∞ performance control of a class T-S fuzzy system

Science.gov (United States)

Wang, Yanhua; He, Xiqin; Wu, Zhihua; Kang, Xiulan; Xiu, Wei

2018-03-01

For much nonlinear system in the control system, both the stability of the system and certain performance indicators are required. The characteristics of T-S model in fuzzy system make it possible to illustrate a great amount of nonlinear system efficiently. First and foremost, the T-S model with uncertainties and external disturbance is utilized to interpret nonlinear system so as to implement H∞ performance control by means of fuzzy control theory. Meantime, owing to the tremendous existence of time delay phenomenon in the controlled, feedback controller with memory fuzzy state is fabricated. On the basis of Lyapunov Stability Theory, the closed-loop system becomes stable by establishing Lyapunov function. Gain matrix of the memory state feedback controller is obtained by applying linear matrix inequality methodology. And simultaneously it makes the system meet the requirement of the H∞ performance indicator. Ultimately, the efficiency of the above-mentioned method is exemplified by the numerical computation.

Safety inspections - the role of TS : risks, their assessment and the role of safety systems

CERN Document Server

Béjar-Alonso, Isabel; CERN. Geneva. TS Department

2008-01-01

In 2007 the DG decided a new approach for safety at CERN. This had as consequence the creation of a new unit, the safety service provider, in the TS department. The organization and the services that this unit provides to CERN will be described and the achievements since the creation of the unit will be summarized. Some important personnel safety systems, on their side have been the responsibility of the TS Department for many years. Their importance has grown with the arrival of LHC and their complexity and impact on operation has increased. Their role as well as the importance of an appropriate regulatory framework shall be discussed.

Surface modification of aluminum nitride by polysilazane and its polymer-derived amorphous silicon oxycarbide ceramic for the enhancement of thermal conductivity in silicone rubber composite

Science.gov (United States)

Chiu, Hsien Tang; Sukachonmakul, Tanapon; Kuo, Ming Tai; Wang, Yu Hsiang; Wattanakul, Karnthidaporn

2014-02-01

Polysilazane (PSZ) and its polymer-derived amorphous silicon oxycarbide (SiOC) ceramic were coated on aluminum nitride (AlN) by using a dip-coating method to allow moisture-crosslinking of PSZ on AlN, followed by heat treatment at 700 °C in air to convert PSZ into SiOC on AlN. The results from FTIR, XPS and SEM indicated that the surface of AlN was successfully coated by PSZ and SiOC film. It was found that the introduction of PSZ and SiOC film help improve in the interfacial adhesion between the modified AlN (PSZ/AlN and SiOC/AlN) and silicone rubber lead to the increase in the thermal conductivity of the composites since the thermal boundary resistance at the filler-matrix interface was decreased. However, the introduction of SiOC as an intermediate layer between AlN and silicone rubber could help increase the thermal energy transport at the filler-matrix interface rather than using PSZ. This result was due to the decrease in the surface roughness and thickness of SiOC film after heat treatment at 700 °C in air. Thus, in the present work, a SiOC ceramic coating could provide a new surface modification for the improvement of the interfacial adhesion between the thermally conductive filler and the matrix in which can enhance the thermal conductivity of the composites.

TS LOOP ALCOVE VENTILATION ANALYSIS

International Nuclear Information System (INIS)

T.M. Lahnalampi

2000-01-01

The scope of this analysis is to examine the existing, constructor installed, physical ventilation installations located in each of the Exploratory Studies Facility (ESF) Topopah Springs (TS) Loop Alcoves No.1, No.2, No.3, No.4, No.6, and No.7. Alcove No.5 is excluded from the scope of this analysis since it is an A/E design system. Each ventilation installation will be analyzed for the purpose of determining if requirements for acceptance into the A/E design technical baseline have been met. The ventilation installations will be evaluated using Occupational Safety and Health Administration (OSHA) standards and Exploratory Studies Facility Design Requirements (ESFDR) (YMP 1997) requirements. The end product will be a technical analysis that will define ventilation installation compliance issues, any outstanding field changes, and use-as-is design deviations that are required to bring the ventilation installations into compliance with requirements for acceptance into the A/E design technical baseline. The analysis will provide guidance for alcove ventilation component design modifications to be developed to correct any deficient components that do not meet minimum requirements and standards

A Universal Ts-VI Triangle Method for the Continuous Retrieval of Evaporative Fraction From MODIS Products

Science.gov (United States)

Zhu, Wenbin; Jia, Shaofeng; Lv, Aifeng

2017-10-01

The triangle method based on the spatial relationship between remotely sensed land surface temperature (Ts) and vegetation index (VI) has been widely used for the estimates of evaporative fraction (EF). In the present study, a universal triangle method was proposed by transforming the Ts-VI feature space from a regional scale to a pixel scale. The retrieval of EF is only related to the boundary conditions at pixel scale, regardless of the Ts-VI configuration over the spatial domain. The boundary conditions of each pixel are composed of the theoretical dry edge determined by the surface energy balance principle and the wet edge determined by the average air temperature of open water. The universal triangle method was validated using the EF observations collected by the Energy Balance Bowen Ratio systems in the Southern Great Plains of the United States of America (USA). Two parameterization schemes of EF were used to demonstrate their applicability with Terra Moderate Resolution Imaging Spectroradiometer (MODIS) products over the whole year 2004. The results of this study show that the accuracy produced by both of these two parameterization schemes is comparable to that produced by the traditional triangle method, although the universal triangle method seems specifically suited to the parameterization scheme proposed in our previous research. The independence of the universal triangle method from the Ts-VI feature space makes it possible to conduct a continuous monitoring of evapotranspiration and soil moisture. That is just the ability the traditional triangle method does not possess.

Vom Stabilitäts- und Wachstumsgesetz zum Wohlstands- und Nachhaltigkeitsgesetz

OpenAIRE

Koll, Willi

2016-01-01

Das Stabilitäts- und Wachstumsgesetz wird bald 50 Jahre alt. Neue Herausforderungen erfordern eine Wirtschaftspolitik, die weit über die Ziele des Gesetzes hinausweist. Sie muss wirtschaftliches Wachstum und Stabilität mit den Zielen fiskalischer, sozialer und ökologischer Nachhaltigkeit auf nationaler und europäischer Ebene verbinden. Der Autor gibt einen Über blick über solche umfassenden Zielsysteme und leitet daraus ab, wie eine derart erweiterte wirtschaftspolitische Agenda in ein Wohlst...

A guide to the suitability of elastomeric seal materials for use in radioactive material transport packages

International Nuclear Information System (INIS)

Vince, D.J.

2004-01-01

Elastomeric seals are a frequently favoured method of sealing Radioactive Material Transport (RMT) packages. The sealing technology has been proven for many years in a wide range of industrial applications. The requirements of the RMT package applications, however, are significantly different from those commonly found in other industries. This guide outlines the Regulatory performance requirements placed on an RMT package sealing system by TS-R-1, and then summarises the material, environment and geometry characteristics of elastomeric seals relevant to RMT applications. Tables in the guide list typical material properties for a range of elastomeric materials commonly used in RMT packages

Usuga tõe ja töö vabariiki / Matti Päts ; interv. Ants Sild

Index Scriptorium Estoniae

Päts, Matti, 1933-

2003-01-01

Patendiameti peadirektor Matti Päts vastab küsimustele, mis puudutavad Eesti Vabariiki selle 12. taasiseseisvumisaastal, eesti ajakirjandust, segadust ühiskonnas, kokkuhoidliku meelelaadi kadumist, insenerkonna vähest esindatust ühiskonnaelu juhtimises, maaelu

Effect of Instrument Design and Access Outlines on the Removal of Root Canal Obturation Materials in Oval-shaped Canals.

Science.gov (United States)

Niemi, Tuomas K; Marchesan, Melissa A; Lloyd, Adam; Seltzer, Robert J

2016-10-01

The aim of this study was to compare the effectiveness of TRUShape (TS) instruments with ProFile Vortex Blue (VB) instruments for the removal of obturation materials during retreatment of single-canal mandibular premolars performed through 2 access outlines. Initial root canal treatment was completed through a contracted endodontic cavity (CEC) design. Canals were instrumented to an F2 ProTaper instrument, obturated with warm lateral condensation of gutta-percha with AH Plus sealer, and allowed to set for 30 days at 37°C and 100% humidity. For retreatment, specimens were divided into 2 groups (n = 24) on the basis of access outline, CEC or traditional endodontic cavity (TEC). Retreatment was initiated by using ProTaper Retreatment instruments (D1-D3). Specimens were then stratified, further divided (n = 12), and reinstrumented up to TS 40 .06v or 40 .06 VB. Irrigation was performed by using 8.25% NaOCl and QMix 2in1. Retreatment time was recorded. Teeth were sectioned and photographed, and the percentage of remaining obturation materials was measured. Data were analyzed with Kruskal-Wallis analysis of variance for two-factor tests (α canal surface when compared with TEC-VB, CEC-TS, and TEC-TS (P ≤ .05). None of these other combinations were different from each other (P > .05). Significantly more time was required for retreatment with CEC-TS (27.68 ± 1.4 minutes) than the other groups (P root canal surface of mandibular premolars. However, in the presence of a CEC access design, using TS instruments removed more obturating material in single-rooted, oval-shaped canals. Copyright © 2016 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.

LIDAR TS for ITER core plasma. Part I: layout & hardware

Science.gov (United States)

Salzmann, H.; Gowers, C.; Nielsen, P.

2017-12-01

The original time-of-flight design of the Thomson scattering diagnostic for the ITER core plasma has been shown up by ITER. This decision was justified by insufficiencies of some of the components. In this paper we show that with available, present day technology a LIDAR TS system is feasible which meets all the ITER specifications. As opposed to the conventional TS system the LIDAR TS also measures the high field side of the plasma. The optical layout of the front end has been changed only little in comparison with the latest one considered by ITER. The main change is that it offers an optical collection without any vignetting over the low field side. The throughput of the system is defined only by the size and the angle of acceptance of the detectors. This, in combination with the fact that the LIDAR system uses only one set of spectral channels for the whole line of sight, means that no absolute calibration using Raman or Rayleigh scattering from a non-hydrogen isotope gas fill of the vessel is needed. Alignment of the system is easy since the collection optics view the footprint of the laser on the inner wall. In the described design we use, simultaneously, two different wavelength pulses from a Nd:YAG laser system. Its fundamental wavelength ensures measurements of 2 keV up to more than 40 keV, whereas the injection of the second harmonic enables measurements of low temperatures. As it is the purpose of this paper to show the technological feasibility of the LIDAR system, the hardware is considered in Part I of the paper. In Part II we demonstrate by numerical simulations that the accuracy of the measurements as required by ITER is maintained throughout the given plasma parameter range. The effect of enhanced background radiation in the wavelength range 400 nm-500 nm is considered. In Part III the recovery of calibration in case of changing spectral transmission of the front end is treated. We also investigate how to improve the spatial resolution at the

Influence de l’anthropisation sur la végétation locale et l’abondance des tsé-tsé au sud du Burkina Faso*

Directory of Open Access Journals (Sweden)

Rayaissé J.B.

2009-03-01

Full Text Available Des enquêtes entomologiques couplées à une analyse phytosociologique ont été menées dans la zone de Folonzo au sud du Burkina Faso sur la rivière Comoé. L’étude avait pour objectif de comparer l’abondance et la diversité des espèces de glossines dans une zone protégée et une zone non protégée, grâce à des transects perpendiculaires au cours d’eau. Des pièges ont été posés le long de ces transects depuis la rivière Comoé jusqu’à la savane en passant par la galerie forestière. Une analyse diachronique de la zone entre 1980 et 2008 a également été menée par comparaison d’images satellites Landsat et à partir de l’évolution des densités de tsé-tsé. Sur chacun des transects, une description de la flore a été faite, incluant toutes les espèces situées dans un rayon de 10 m autour de chaque piège. Il existe une très grande homogénéité floristique entre les transects, particulièrement pour la forêt-galerie, en revanche la savane montre une relative hétérogénéité. L’enquête entomologique révèle la présence de quatre espèces de glossines qui sont Glossina tachinoides (74 %, G. morsitans submorsitans (20 %, G. palpalis gambiensis (4 % et G. medicorum (2 %. Une différence nette s’observe entre la zone non protégée et la zone protégée, avec une densité moyenne de tsé-tsé quatre fois inférieure dans la première. Cette différence est particulièrement importante pour G. m. submorsitans, dont les densités sont divisées par neuf dans la zone non protégée. Cette régression s’explique par la diminution de la faune sauvage hors de la zone protégée, et ceci est extrapolable à l’ensemble du pays où cette espèce de glossine est en net recul. L’évolution du terroir de Folonzo montre une augmentation impressionnante des densités humaines et des surfaces cultivées, qui n’a pas (encore d’impact visible sur la composition floristique des lieux d’analyse, mais qui

T-S criticality of black holes with power Maxwell invariant source

Science.gov (United States)

Lin, Ze-Tao; Li, Gu-Qiang; Long, Kun; He, Fang; Mo, Jie-Xiong

2017-09-01

In this paper, we show that black holes with PMI source exhibit the T-S criticality and derive the relevant critical physical quantities analytically. The values of critical quantities for the case s≠1 vary from those for the case s=1, showing the effect of PMI field on the critical phenomena of black holes. When qPMI field does not affect the Maxwell equal area law.

A novel concurrent chemoradiotherapy with TS-1/nedaplatin for esophageal cancer showing better quality of life durning treatment

International Nuclear Information System (INIS)

Miyazaki, Aya; Inaba, Hiroyuki; Tsuda, Takashi; Itoh, Fumio

2005-01-01

Concurrent chemoradiotherapy (CRT) for esophageal cancer is expected to achieve adequate quality of life (QOL) and to improve the survival of patients. As a QOL-oriented therapy for esophageal cancer, concurrent CRT with tegafur·gimestat·otastat potassium (TS-1)/nedaplatin (CDGP) was developed and evaluated. Between June 2001 and September 2002, 18 patients with esophageal cancer were enrolled in a clinical study of concurrent CRT with TS-1/CDGP. To evaluate the impact of treatment on the QOL, the patients were asked to answer QOL Questionnaire for Cancer Patients Treated with Anticancer Drugs (QOL-ACD) before and after therapy. The response rate was 66.7%, with a complete response occurring in 9 (50.0%) of the 18 patients. Patients with improved global, functional, or mental QOL after therapy showed or tended to show a significant, longer survival. Compared to patients previously treated by the same regimen with 5-fluorouracil (5-FU) instead of TS-1, those receiving the present therapy were able to leave hospital more frequently during treatment. TS-1/CDGP-based CRT for esophageal cancer exhibited comparable antitumor activity and survival benefit as with standard 5-FU/cisplatin (CDDP)-based CRT without causing serious side-effects. The patients receiving the present therapy seemed to have a better chance of maintaining their QOL. (author)

Production of biogas from plant materials

Energy Technology Data Exchange (ETDEWEB)

Zuer, J.

1980-12-01

Different crop residues from agriculture and horticulture were investigated for feasibility of producing biogas. The anaerobic fermentation has been performed in batch system fermentation reactors (5 liters) at mesophilic conditions (35 degrees C). Content of volatile solids (VS/TS) in raw materials varied from 78.5 percent in silage from top of sugar beet to 97.3 percent in straw of rye. The highest content of lignin was found in stalks of Jerusalem artichoke (49.6 percent), stalks of horse bean (47.6 percent) and the lowest in leaves of cauliflower (9.5 percent), top of sugar beet and leaves of cabbage (11 percent) in both. Ratio of carbon to nitrogen was the highest in the straw of rye (60) and the lowest in silage from top of sugar beet (11) and in leaves of cauliflower (11). Rate of biogas production during the first 13 days of fermentation was about 27 liters per kg TS per day, achieved from top of sugar beet. Typical mean rate of biogas production, about 9 liters per kg TS per day, was performed during the first 40 days of retention time from straw of wheat and stalks of rape. Top of sugar beet and manure slurry have had the shortest effective retention time ca 20 days. Maximum total yield of biogas (427.0 liters per kg TS) was achieved from top of sugar beet. From manure slurry 257.5 liters biogas per kg TS was obtained. Methane content in biogas produced during the final 7 days of retention time was the highest from silage from top of artichoke (72.8 percent), stalks of horse bean (71.6 percent) and straw of wheat (71.0 percent). The lowest percentage of methane (59.0 percent) was found in biogas from top of sugar beet.

Adaptive Controller for 6-DOF Parallel Robot Using T-S Fuzzy Inference

Directory of Open Access Journals (Sweden)

Xue Jian

2013-02-01

Full Text Available 6-DOF parallel robot always appears in the form of Stewart platform. It has been widely used in industry for the benefits such as strong structural stiffness, high movement accuracy and so on. Space docking technology makes higher requirements of motion accuracy and dynamic performance to the control method on 6-DOF parallel robot. In this paper, a hydraulic 6-DOF parallel robot was used to simulate the docking process. Based on this point, this paper gave a thorough study on the design of an adaptive controller to eliminate the asymmetric of controlled plant and uncertain load force interference. Takagi-Sugeno (T-S fuzzy inference model was used to build the fuzzy adaptive controller. With T-S model, the controller directly imposes adaptive control signal on the plant to make sure that the output of plant could track the reference model output. The controller has simple structure and is easy to implement. Experiment results show that the controller can eliminate asymmetric and achieve good dynamic performance, and has good robustness to load interference.

Robust adaptive controller design for a class of uncertain nonlinear systems using online T-S fuzzy-neural modeling approach.

Science.gov (United States)

Chien, Yi-Hsing; Wang, Wei-Yen; Leu, Yih-Guang; Lee, Tsu-Tian

2011-04-01

This paper proposes a novel method of online modeling and control via the Takagi-Sugeno (T-S) fuzzy-neural model for a class of uncertain nonlinear systems with some kinds of outputs. Although studies about adaptive T-S fuzzy-neural controllers have been made on some nonaffine nonlinear systems, little is known about the more complicated uncertain nonlinear systems. Because the nonlinear functions of the systems are uncertain, traditional T-S fuzzy control methods can model and control them only with great difficulty, if at all. Instead of modeling these uncertain functions directly, we propose that a T-S fuzzy-neural model approximates a so-called virtual linearized system (VLS) of the system, which includes modeling errors and external disturbances. We also propose an online identification algorithm for the VLS and put significant emphasis on robust tracking controller design using an adaptive scheme for the uncertain systems. Moreover, the stability of the closed-loop systems is proven by using strictly positive real Lyapunov theory. The proposed overall scheme guarantees that the outputs of the closed-loop systems asymptotically track the desired output trajectories. To illustrate the effectiveness and applicability of the proposed method, simulation results are given in this paper.

Systematic and material independent variation of electrical, optical, and chemical properties of Ln-materials over the Ln-series (Ln=La,Ce,Pr,..,Lu)

NARCIS (Netherlands)

Van der Kolk, E.; Dorenbos, P.

2007-01-01

A model is presented that successfully predicts electro-optical properties of Lanthanide materials, irrespective whether these materials are inorganic or organic, diluted or concentrated, metallic, semi-conducting or insulating. The model is firmly based on recent experimental data revealing that

The impact of hot melt extrusion and spray drying on mechanical properties and tableting indices of materials used in pharmaceutical development.

Science.gov (United States)

Iyer, Raman; Hegde, Shridhar; Zhang, Yu-E; Dinunzio, James; Singhal, Dharmendra; Malick, A; Amidon, Gregory

2013-10-01

The impact of melt extrusion (HME) and spray drying (SD) on mechanical properties of hypromellose acetate succinate (HPMCAS), copovidone, and their formulated blends was studied and compared with that of reference excipients. Tensile strength (TS), compression pressure (CP), elastic modulus (E), and dynamic hardness (Hd ) were determined along with Hiestand indices using compacts prepared at a solid fraction of ∼0.85. HPMCAS and copovidone exhibited lower Hd , lower CP, and lower E than the reference excipients and moderate TS. HPMCAS was found to be highly brittle based on brittle fracture index values. The CP was 24% and 61% higher for HPMCAS after SD and HME, respectively, than for unprocessed material along with a higher Hd . Furthermore, the TS of HPMCAS and copovidone decreased upon HME. Upon blending melt-extruded HPMCAS with plastic materials such as microcrystalline cellulose, the TS increased. These results suggest that SD and HME could impact reworkability by reducing deformation of materials and in case of HME, likely by increasing density due to heating and shear stress in a screw extruder. A somewhat similar effect was observed for the dynamic binding index (BId ) of the excipients and formulated blends. Such data can be used to quantitate the impact of processing on mechanical properties of materials during tablet formulation development. © 2013 Wiley Periodicals, Inc. and the American Pharmacists Association.

Influencia del apantallamiento en la propagación subcrítica de fisuras en materiales de circona

Directory of Open Access Journals (Sweden)

Casellas, D.

2001-04-01

Full Text Available The increase in fatigue life under a constant applied load, due to the presence of crack shielding, was studied. Time to failure was estimated by using a mathematical function that describes the crack shielding developed during subcritical crack growth. Such results were compared with experimental fatigue lives obtained in Y-TZP/PSZ materials. From this it may be concluded that the initial slope of crack shielding curves greatly influences the time to failure.

Se ha estudiado el aumento en el tiempo a rotura bajo la aplicación de una carga constante debido a la presencia de apantallamiento. Este tiempo se evaluó considerando una función matemática que describe el apantallamiento desarrollado en propagación subcrítica y los valores obtenidos se comparan con resultados experimentales correspondientes a materiales Y-TZP/PSZ. Se concluye que la pendiente inicial de la curva de apantallamiento ejerce gran influencia en la vida a fatiga del material.

Zirconia toughened ceramics for heat engine applications

International Nuclear Information System (INIS)

Rossi, G.A.; Blum, J.B.; Manwiller, K.E.; Knapp, C.E.

1986-01-01

Three classes of zirconia toughened ceramics (ZTC) were studied, i.e. Mg-PSZ (MgO-partially stabilized zirconia), Y-TZP (Y/sub 2/O/sub 3/-tetragonal zirconia polycrystals) and ZTA (zirconia toughened alumina). The main objective was to improve the high temperature strength and toughness, which are not satisfactory in the ''state of the art'' ZTC materials. Powders prepared by melting/rapid solidification and by chemical routes were used. The green parts were made by both dry and wet shape forming methods. Fine grained Mg-PSZ ceramics with unique microstructures were produced using the rapidly solidified powders. The Y-TZP materials were improved mainly through microstructure control and by addition of alpha alumina as a dispersed phase. Preliminary results on ZTA ceramics made with the rapidly solidified powders were also obtained. It is concluded that the Al/sub 2/O/sub 3//Y-TZP composites offer a good chance of meeting the program objectives

Rotating bending fatigue strength evaluation of ceramic materials

International Nuclear Information System (INIS)

Govila, R.K.; Swank, L.R.

1995-01-01

Cyclic fatigue under rotary bending tests were conducted on partially stabilized zirconia (PSZ) from NGK and Nilsen, and silicon nitride from NGK and Norton. Fractography was performed on the failed specimens to determine the fracture structure and morphology. The results showed that the cyclic fatigue fracture was the same as the fracture structure previously observed in bending tests. The cyclic fatigue data indicated that structural ceramic could function in fatigue stress levels at a higher percentage of their average fast fracture strength than the fifty percent of ultimate strength used for wrought steels

A Heuristic T-S Fuzzy Model for the Pumped-Storage Generator-Motor Using Variable-Length Tree-Seed Algorithm-Based Competitive Agglomeration

Directory of Open Access Journals (Sweden)

Jianzhong Zhou

2018-04-01

Full Text Available With the fast development of artificial intelligence techniques, data-driven modeling approaches are becoming hotspots in both academic research and engineering practice. This paper proposes a novel data-driven T-S fuzzy model to precisely describe the complicated dynamic behaviors of pumped storage generator motor (PSGM. In premise fuzzy partition of the proposed T-S fuzzy model, a novel variable-length tree-seed algorithm based competitive agglomeration (VTSA-CA algorithm is presented to determine the optimal number of clusters automatically and improve the fuzzy clustering performances. Besides, in order to promote modeling accuracy of PSGM, the input and output formats in the T-S fuzzy model are selected by an economical parameter controlled auto-regressive (CAR model derived from a high-order transfer function of PSGM considering the distributed components in the water diversion system of the power plant. The effectiveness and superiority of the T-S fuzzy model for PSGM under different working conditions are validated by performing comparative studies with both practical data and the conventional mechanistic model.

Application of ISO/TS 16949:2009 in Forest Products Industry

OpenAIRE

SEVİM KORKUT, Derya; SOLAK, Ertan

2016-01-01

The aim of the study is to present the short, medium and long term benefits of the activities in the basis of quality management development and in the context of ISO/TS 16949 Automotive Sub-Industry Quality Management System which determines the service standards of a forest products facility as an automotive sub-industry supplier, to be shown as an example to similar facilities. In this study which aims to present the facility’s character an examination has been done via supplier, productio...

Dos and Don'ts of Giving OTC Cough and Cold Medicines to Your Child

Science.gov (United States)

... workers, extended family members, or babysitters) knows what medicines your child is taking and when he or she should ... ts Don’t give OTC cough and cold medicines to a child younger than 4 years of age unless your ...

Utilization of Delignified Sawdust as Raw Material of Biogas Production

Directory of Open Access Journals (Sweden)

Zumalla Asfarina

2018-01-01

Full Text Available Biogas is one alternative to replace the irreplaceable energy source that has begun to diminish its existence. The raw materials for biogas manufacture are renewable biomass, usually using plantation waste, agriculture, and livestock. Using biogas can also reduce environmental pollution. One of the agricultural waste that has great potential to become the raw material of biogas is teak sawdust. Wood processing industry in Indonesia quite a lot, but wood has a high lignosesluosa content, so it needs the right method to process it. With the delignification of lignin levels on teak sawdust will decrease. Wood sawdust is soaked using NaOH for 1, 2, 3, and 4 days with 4% w / v concentration. The lowest lignin and hemicellulose content was 25.79% and 87.9% in pretreatment for 4 days, while the highest cellulose level was 57, 34%. The accumulated volume of biogas at 1 day pretreatment, ie 709 ml / g TS. Gcms shows the enlarged peak area of methanamine, N-methyl from before pretreatment. The fastest biogas formation (λ in 4 days pretreatment, 1.60403 days and the largest constant A and U variables at 1 day were 914.5903 ml / g TS and 34.59765 ml / g TS.

Elongation Factor Ts Directly Facilitates the Formation and Disassembly of the Escherichia coli Elongation Factor Tu·GTP·Aminoacyl-tRNA Ternary Complex*

Science.gov (United States)

Burnett, Benjamin J.; Altman, Roger B.; Ferrao, Ryan; Alejo, Jose L.; Kaur, Navdep; Kanji, Joshua; Blanchard, Scott C.

2013-01-01

Aminoacyl-tRNA enters the translating ribosome in a ternary complex with elongation factor Tu (EF-Tu) and GTP. Here, we describe bulk steady state and pre-steady state fluorescence methods that enabled us to quantitatively explore the kinetic features of Escherichia coli ternary complex formation and decay. The data obtained suggest that both processes are controlled by a nucleotide-dependent, rate-determining conformational change in EF-Tu. Unexpectedly, we found that this conformational change is accelerated by elongation factor Ts (EF-Ts), the guanosine nucleotide exchange factor for EF-Tu. Notably, EF-Ts attenuates the affinity of EF-Tu for GTP and destabilizes ternary complex in the presence of non-hydrolyzable GTP analogs. These results suggest that EF-Ts serves an unanticipated role in the cell of actively regulating the abundance and stability of ternary complex in a manner that contributes to rapid and faithful protein synthesis. PMID:23539628

Biochemical characterization of the triticale TsPAP1, a new type of plant prolyl aminopeptidase, and its impact on proline content and flowering time in transgenic Arabidopsis plants.

Science.gov (United States)

Zdunek-Zastocka, Edyta; Grabowska, Agnieszka; Branicki, Tomasz; Michniewska, Beata

2017-07-01

Proline aminopeptidase (PAP, EC 3.4.11.5) is the only enzyme that effectively releases proline from the N-termini of peptides. The amino acid sequence of the PAP from Triticosecale, TsPAP1, comprises conserved regions, characteristic of the monomeric forms of PAP found in bacteria but not yet identified in plants. Therefore, we aimed to obtain and biochemically characterize the TsPAP1 protein. The recombinant TsPAP1 protein was received through heterologous expression of the TsPAP1 coding sequence in a bacterial expression system and purified with affinity chromatography. Gel filtration chromatography and SDS electrophoresis revealed that TsPAP1 is a monomer with a molecular mass of 37.5 kDa. TsPAP1 prefers substrates with proline at the N-terminus but is also capable of hydrolyzing β-naphthylamides of hydroxyproline and alanine. Among the peptides tested, the most preferred were di- and tripeptides, especially those with glycine in the Y position. The use of diagnostic inhibitors indicated that TsPAP1 is a serine peptidase; however, further characterization revealed that the SH residues are also important for maintaining its activity. To examine the role of TsPAP1 under physiological conditions, we developed transgenic Arabidopsis plants overexpressing TsPAP1. Compared with wild-type plants, the transgenic lines accumulated more proline, flowered an average of 3.5 days earlier, and developed more siliques than did untransformed controls. Our paper is the first to describe the biochemical properties of a novel monomeric plant PAP and contributes to the functional characterization of PAP proteins in plants. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

Improved Stabilization Conditions for Nonlinear Systems with Input and State Delays via T-S Fuzzy Model

Directory of Open Access Journals (Sweden)

Chang Che

2018-01-01

Full Text Available This paper focuses on the problem of nonlinear systems with input and state delays. The considered nonlinear systems are represented by Takagi-Sugeno (T-S fuzzy model. A new state feedback control approach is introduced for T-S fuzzy systems with input delay and state delays. A new Lyapunov-Krasovskii functional is employed to derive less conservative stability conditions by incorporating a recently developed Wirtinger-based integral inequality. Based on the Lyapunov stability criterion, a series of linear matrix inequalities (LMIs are obtained by using the slack variables and integral inequality, which guarantees the asymptotic stability of the closed-loop system. Several numerical examples are given to show the advantages of the proposed results.

75 FR 67705 - Office of Postsecondary Education; Overview Information; Talent Search (TS) Program; Notice...

Science.gov (United States)

2010-11-03

... DEPARTMENT OF EDUCATION Office of Postsecondary Education; Overview Information; Talent Search (TS... currently being served by a Talent Search project, especially schools that the State has identified as the... reliable third-party sources when providing information on the implementation of their Talent Search...

Galantamine improves olfactory learning in the Ts65Dn mouse model of Down syndrome.

Science.gov (United States)

de Souza, Fabio M Simoes; Busquet, Nicolas; Blatner, Megan; Maclean, Kenneth N; Restrepo, Diego

2011-01-01

Down syndrome (DS) is the most common form of congenital intellectual disability. Although DS involves multiple disturbances in various tissues, there is little doubt that in terms of quality of life cognitive impairment is the most serious facet and there is no effective treatment for this aspect of the syndrome. The Ts65Dn mouse model of DS recapitulates multiple aspects of DS including cognitive impairment. Here the Ts65Dn mouse model of DS was evaluated in an associative learning paradigm based on olfactory cues. In contrast to disomic controls, trisomic mice exhibited significant deficits in olfactory learning. Treatment of trisomic mice with the acetylcholinesterase inhibitor galantamine resulted in a significant improvement in olfactory learning. Collectively, our study indicates that olfactory learning can be a sensitive tool for evaluating deficits in associative learning in mouse models of DS and that galantamine has therapeutic potential for improving cognitive abilities.

Second Generation HTs Wire Based on RABiTS Substrates and MOD YBCO

Energy Technology Data Exchange (ETDEWEB)

Schoop, U. [American Superconductor Corporation, Westborough, MA; Rupich, Marty [American Superconductor Corporation, Westborough, MA; Thieme, C. L. H. [American Superconductor Corporation, Westborough, MA; Verebelyi, D. T. [American Superconductor Corporation, Westborough, MA; Zhang, W. [American Superconductor Corporation, Westborough, MA; Li, Xiaoping [American Superconductor Corporation, Westborough, MA; Kodenkandath, Thomas [American Superconductor Corporation, Westborough, MA; Nguyen, N. [American Superconductor Corporation, Westborough, MA; Siegal, E. E. [American Superconductor Corporation, Westborough, MA; Civale, L. [Los Alamos National Laboratory (LANL); Holesinger, T. G. [Los Alamos National Laboratory (LANL); Maiorov, B. [Los Alamos National Laboratory (LANL); Goyal, Amit [ORNL; Paranthaman, Mariappan Parans [ORNL

2005-01-01

The performance of Second Generation (2G) high temperature superconducting wire manufactured by continuous reel-to-reel processes is nearing the 300 A/cm-width (77 K, self field) performance threshold for commercial power cable applications. The 2G manufacturing approach under development at American Superconductor is based on the combination of the RABiTS substrate-buffer technology with metal organic deposition (MOD) of the YBCO layer. The capability of this process has been demonstrated in multiple 10 meter lengths with critical currents exceeding 250 A/cm-width with high uniformity and reproducibility. Critical currents of 380 A/cm-width have been achieved in short length samples prepared by the same basic process. The incorporation of nanoparticles ('nanodots') into the YBCO layer using the MOD process has resulted in a 2-fold improvement in the critical current at 65 K in a 3 T field. The research and development focus at ASMC is now directed toward the economical scale-up of the RABiTS/MOD process, optimization of the conductor properties for targeted applications and the use of 2G wire in initial demonstration applications.

Impôts, taxes et équité entre les sexes : codes, comportements et ...

International Development Research Centre (IDRC) Digital Library (Canada)

6 déc. 2010 ... On sait que les impôts et la taxation peuvent favoriser l'égalité socioéconomique, mais ... Analysis of Direct and Indirect Taxes in Developing and Developed Countries. ... Gender and taxation in South Africa: a policy brief.

Guidelines : the do's, don'ts and don't knows of feedback for clinical education

NARCIS (Netherlands)

Lefroy, Janet; Watling, Chris; Teunissen, Pim W; Brand, Paul

2015-01-01

INTRODUCTION: The guidelines offered in this paper aim to amalgamate the literature on formative feedback into practical Do's, Don'ts and Don't Knows for individual clinical supervisors and for the institutions that support clinical learning. METHODS: The authors built consensus by an iterative

TS LOOP NON-POTABLE PUMP EVALUATION

International Nuclear Information System (INIS)

S. Goodin

1999-01-01

This analysis evaluates the existing subsurface non-potable water system from the portal pump to the end of the water line in the South Ramp and determines if the pump size and spacing meets the system pressure and flow requirements for construction operations and incipient fire fighting capability as established in the Subsurface Fire Hazards Analysis (CRWMS M andO 1998b). This analysis does not address the non potable water system in the Cross Drift which is covered under a previous design analysis (CRWMS-M andO 1998a). The Subsurface Fire Hazards Analysis references sections of OSHA 29 CFR 1910 Subpart L for requirements applicable to the incipient fire fighting hose stations used underground. This analysis does not address mechanical system valves, fittings, risers and other components of the system piping. This system is not designed or intended to meet all National Fire Protection Association (NFPA) codes for a fire fighting system but is only considered a backup system to fire extinguishers that are installed throughout the Topopah Springs (TS) Loop and may be used to fight small incipient stage fires

Secretin radioimmunoassay using 125I-6-tyrosyl-secretin (6TS)

International Nuclear Information System (INIS)

Raptis, S.; Leitze, M.; Schlegel, W.; Pfeiffer, E.F.

1975-01-01

In radioimmunological determination of secretin difficulties are caused by the following two problems: firstly, in raising potent antibodies, and secondly in satisfactory labeling. All secretin RIAs described in the literature were carried out with traditional synthetic secretin (Young, Lazarus, Chisholm and Atkinson 1968; Boden and Chey 1973; Holohan, Murphy, Buchanan and Elmore 1973; Boehm, Lee and Chey 1974). Our study describes the development of an assay with sufficient sensitivity to measure circulating immunoreactive secretin in human blood, by using 125 I-6-TS, which is a product of Schwarz and Mann/USA (SM). (orig.) [de

A federated capability-based access control mechanism for internet of things (IoTs)

Science.gov (United States)

Xu, Ronghua; Chen, Yu; Blasch, Erik; Chen, Genshe

2018-05-01

The prevalence of Internet of Things (IoTs) allows heterogeneous embedded smart devices to collaboratively provide intelligent services with or without human intervention. While leveraging the large-scale IoT-based applications like Smart Gird and Smart Cities, IoT also incurs more concerns on privacy and security. Among the top security challenges that IoTs face is that access authorization is critical in resource and information protection over IoTs. Traditional access control approaches, like Access Control Lists (ACL), Role-based Access Control (RBAC) and Attribute-based Access Control (ABAC), are not able to provide a scalable, manageable and efficient mechanisms to meet requirement of IoT systems. The extraordinary large number of nodes, heterogeneity as well as dynamicity, necessitate more fine-grained, lightweight mechanisms for IoT devices. In this paper, a federated capability-based access control (FedCAC) framework is proposed to enable an effective access control processes to devices, services and information in large scale IoT systems. The federated capability delegation mechanism, based on a propagation tree, is illustrated for access permission propagation. An identity-based capability token management strategy is presented, which involves registering, propagation and revocation of the access authorization. Through delegating centralized authorization decision-making policy to local domain delegator, the access authorization process is locally conducted on the service provider that integrates situational awareness (SAW) and customized contextual conditions. Implemented and tested on both resources-constrained devices, like smart sensors and Raspberry PI, and non-resource-constrained devices, like laptops and smart phones, our experimental results demonstrate the feasibility of the proposed FedCAC approach to offer a scalable, lightweight and fine-grained access control solution to IoT systems connected to a system network.

Pre- and post-natal melatonin administration partially regulates brain oxidative stress but does not improve cognitive or histological alterations in the Ts65Dn mouse model of Down syndrome.

Science.gov (United States)

Corrales, Andrea; Parisotto, Eduardo B; Vidal, Verónica; García-Cerro, Susana; Lantigua, Sara; Diego, Marian; Wilhem Filho, Danilo; Sanchez-Barceló, Emilio J; Martínez-Cué, Carmen; Rueda, Noemí

2017-09-15

Melatonin administered during adulthood induces beneficial effects on cognition and neuroprotection in the Ts65Dn (TS) mouse model of Down syndrome. Here, we investigated the effects of pre- and post-natal melatonin treatment on behavioral and cognitive abnormalities and on several neuromorphological alterations (hypocellularity, neurogenesis impairment and increased oxidative stress) that appear during the early developmental stages in TS mice. Pregnant TS females were orally treated with melatonin or vehicle from the time of conception until the weaning of the offspring, and the pups continued to receive the treatment from weaning until the age of 5 months. Melatonin administered during the pre- and post-natal periods did not improve the cognitive impairment of TS mice as measured by the Morris Water maze or fear conditioning tests. Histological alterations, such as decreased proliferation (Ki67+ cells) and hippocampal hypocellularity (DAPI+ cells), which are typical in TS mice, were not prevented by melatonin. However, melatonin partially regulated brain oxidative stress by modulating the activity of the primary antioxidant enzymes (superoxide dismutase in the cortex and catalase in the cortex and hippocampus) and slightly decreasing the levels of lipid peroxidation in the hippocampus of TS mice. These results show the inability of melatonin to prevent cognitive impairment in TS mice when it is administered at pre- and post-natal stages. Additionally, our findings suggest that to induce pro-cognitive effects in TS mice during the early stages of development, in addition to attenuating oxidative stress, therapies should aim to improve other altered processes, such as hippocampal neurogenesis and/or hypocellularity. Copyright © 2017 Elsevier B.V. All rights reserved.

Geomagnetic activity at Northern Hemisphere's mid-latitude ground stations: How much can be explained using TS05 model

Science.gov (United States)

Castillo, Yvelice; Pais, Maria Alexandra; Fernandes, João; Ribeiro, Paulo; Morozova, Anna L.; Pinheiro, Fernando J. G.

2017-12-01

For the 2007 to 2014 period, we use a statistical approach to evaluate the performance of Tsyganenko and Sitnov [2005] semi-empirical model (TS05) in estimating the magnetospheric transient signal observed at four Northern Hemisphere mid-latitude ground stations: Coimbra, Portugal; Panagyurishte, Bulgary; Novosibirsk, Russia and Boulder, USA. Using hourly mean data, we find that the TS05 performance is clearly better for the X (North-South) than for the Y (East-West) field components and for more geomagnetically active days as determined by local K-indices. In ∼ 50% (X) and ∼ 30% (Y) of the total number of geomagnetically active days, correlation values yield r ≥ 0.7. During more quiet conditions, only ∼ 30% (X) and ∼ 15% (Y) of the number of analyzed days yield r ≥ 0.7. We compute separate contributions from different magnetospheric currents to data time variability and to signal magnitude. During more active days, all tail, symmetric ring and partial ring currents contribute to the time variability of X while the partial ring and field aligned currents contribute most to the time variability of Y. The tail and symmetric ring currents are main contributors to the magnitude of X. In the best case estimations when r ≥ 0.7, remaining differences between observations and TS05 predictions could be explained by global induction in the Earth's upper layers and crustal magnetization. The closing of field aligned currents through the Earth's center in the TS05 model seems to be mainly affecting the Y magnetospheric field predictions.

Bonding of TRIP-Steel/Al2O3-(3Y-TZP Composites and (3Y-TZP Ceramic by a Spark Plasma Sintering (SPS Apparatus

Directory of Open Access Journals (Sweden)

Aslan Miriyev

2016-07-01

Full Text Available A combination of the high damage tolerance of TRIP-steel and the extremely low thermal conductivity of partially stabilized zirconia (PSZ can provide controlled thermal-mechanical properties to sandwich-shaped composite specimens comprising these materials. Sintering the (TRIP-steel-PSZ/PSZ sandwich in a single step is very difficult due to differences in the sintering temperature and densification kinetics of the composite and the ceramic powders. In the present study, we successfully applied a two-step approach involving separate SPS consolidation of pure (3Y-TZP and composites containing 20 vol % TRIP-steel, 40 vol % Al2O3 and 40 vol % (3Y-TZP ceramic phase, and subsequent diffusion joining of both sintered components in an SPS apparatus. The microstructure and properties of the sintered and bonded specimens were characterized. No defects at the interface between the TZP and the composite after joining in the 1050–1150 °C temperature range were observed. Only limited grain growth occurred during joining, while crystallite size, hardness, shear strength and the fraction of the monoclinic phase in the TZP ceramic virtually did not change. The slight increase of the TZP layer’s fracture toughness with the joining temperature was attributed to the effect of grain size on transformation toughening.

Alimentation et dépôts lipidiques chez la truite arc-en-ciel, effet de la température d’élevage

OpenAIRE

Corraze, Geneviève; Larroquet, Laurence; Médale, Françoise

1999-01-01

Cet article fait le point sur la régulation de la genèse des dépôts lipidiques par l’alimentation chez les poissons, sur la base de données bibliographiques existantes et de données personnelles obtenues chez la truite arc-en-ciel (Oncorhynchus mykiss). Chez la truite arc-en-ciel, l’importance quantitative des dépôts lipidiques corporels varie avec la teneur en lipides des aliments, mais les mécanismes de dépôts sont identiques quel que soit le régime alimentaire. Le tissu adipeux périviscéra...

Formation of Me–O–Si covalent bonds at the interface between polysilazane and stainless steel

Energy Technology Data Exchange (ETDEWEB)

Amouzou, Dodji, E-mail: adodji@gmail.com [Research Centre in Physics of Matter and Radiation (PMR), University of Namur, Rue de Bruxelles 61, 5000 Namur (Belgium); Fourdrinier, Lionel; Maseri, Fabrizio [CRM-Group, Boulevard de Colonster, B 57, 4000 Liège (Belgium); Sporken, Robert [Research Centre in Physics of Matter and Radiation (PMR), University of Namur, Rue de Bruxelles 61, 5000 Namur (Belgium)

2014-11-30

Highlights: • Natural metal-oxides, hydroxides are detected on the top surface of steel substrates we tested. • Polysilazane reacts with hydroxide functional groups on steel substrates to form Cr–O–Si and Fe–O–Si covalent bonds. • Covalent bonding between steel and polysilazane at the interface was probed using spectroscopic techniques. - Abstract: In earlier works, we demonstrated the potential of polysilazane (PSZ) coatings for a use as insulating layers in Cu(In,Ga)Se{sub 2} (CIGS) solar cells prepared on steels substrates and showed a good adhesion between PSZ coatings and both AISI316 and AISI430 steels. In the present paper, spectroscopic techniques are used to elucidate the reason of such adhesion. X-ray Photoelectron Spectroscopy (XPS) was used to investigate surfaces for the two steel substrates and showed the presence of metal oxides and metal hydroxides at the top surface. XPS has been also used to probe interfaces between substrates and PSZ, and metallosiloxane (Me–O–Si) covalent bonds have been detected. These results were confirmed by Infra-Red Reflection Absorption Spectroscopy (IRRAS) analyses since vibrations related to Cr–O–Si and Fe–O–Si compounds were detected. Thus, the good adhesion between steel substrates and PSZ coatings was explained by covalent bonding through chemical reactions between PSZ precursors and hydroxide functional groups present on top surface of the two types of steel. Based on these results, an adhesion mechanism between steel substrates and PSZ coatings is proposed.

Two-year survival of glass ionomer sealanTs placed as parT of ...

African Journals Online (AJOL)

2010-09-09

Sep 9, 2010 ... Two-year survival of glass ionomer sealanTs placed as parT of proximal aTraumaTic. resToraTive ... absTracT. Objective: To evaluate after two years, the survival rate of glass ionomer cement (gic) ... or symptoms of periodontal disease, and clinically the ..... saliva contamination on the bond of dentine resin-.

Evaluation of Beef by Electronic Tongue System TS-5000Z: Flavor Assessment, Recognition and Chemical Compositions According to Its Correlation with Flavor.

Directory of Open Access Journals (Sweden)

Xinzhuang Zhang

Full Text Available The aim of this study was to assess the ability of electronic tongue system TS-5000Z to evaluate meat quality based on flavor assessment, recognition and correlation with the meat chemical composition. Meat was sampled from eighteen beef cattle including 6 Wagyu breed cattle, 6 Angus breed cattle and 6 Simmental breed cattle. Chemical composition including dry matter, crude protein, fat, ash, cholesterol and taurine and flavor of the meat were measured. The results showed that different breed cattle had different chemical compositions and flavor, which contains sourness, umami, saltiness, bitterness, astringency, aftertaste from astringency, aftertaste from bitterness and aftertaste from umami, respectively. A principal component analysis (PCA showed an easily visible separation between different breeds of cattle and indicated that TS-5000Z made a rapid identification of different breeds of cattle. In addition, TS-5000Z seemed to be used to predict the chemical composition according to its correlation with the flavor. In conclusion, TS-5000Z would be used as a rapid analytical tool to evaluate the beef quality both qualitatively and quantitatively, based on flavor assessment, recognition and chemical composition according to its correlation with flavor.

poolHiTS: A Shifted Transversal Design based pooling strategy for high-throughput drug screening

Directory of Open Access Journals (Sweden)

Woolf Peter J

2008-05-01

Full Text Available Abstract Background A key goal of drug discovery is to increase the throughput of small molecule screens without sacrificing screening accuracy. High-throughput screening (HTS in drug discovery involves testing a large number of compounds in a biological assay to identify active compounds. Normally, molecules from a large compound library are tested individually to identify the activity of each molecule. Usually a small number of compounds are found to be active, however the presence of false positive and negative testing errors suggests that this one-drug one-assay screening strategy can be significantly improved. Pooling designs are testing schemes that test mixtures of compounds in each assay, thereby generating a screen of the whole compound library in fewer tests. By repeatedly testing compounds in different combinations, pooling designs also allow for error-correction. These pooled designs, for specific experiment parameters, can be simply and efficiently created using the Shifted Transversal Design (STD pooling algorithm. However, drug screening contains a number of key constraints that require specific modifications if this pooling approach is to be useful for practical screen designs. Results In this paper, we introduce a pooling strategy called poolHiTS (Pooled High-Throughput Screening which is based on the STD algorithm. In poolHiTS, we implement a limit on the number of compounds that can be mixed in a single assay. In addition, we show that the STD-based pooling strategy is limited in the error-correction that it can achieve. Due to the mixing constraint, we show that it is more efficient to split a large library into smaller blocks of compounds, which are then tested using an optimized strategy repeated for each block. We package the optimal block selection algorithm into poolHiTS. The MATLAB codes for the poolHiTS algorithm and the corresponding decoding strategy are also provided. Conclusion We have produced a practical version

Development and immunogenicity of recombinant GapA(+) Mycoplasma gallisepticum vaccine strain ts-11 expressing infectious bronchitis virus-S1 glycoprotein and chicken interleukin-6.

Science.gov (United States)

Shil, Pollob K; Kanci, Anna; Browning, Glenn F; Markham, Philip F

2011-04-12

Mycoplasma gallisepticum (MG) is a major pathogen of poultry that causes chronic respiratory disease in chickens and infectious sinusitis in turkeys. A live attenuated vaccine, ts-11, has been used for the control of MG in several countries. The efficacy of this vaccine is highly dose dependent and the flock antibody response is weak. To improve the functionality of the vaccine and investigate its potential as a delivery vector for foreign antigens and immunomodulatory proteins, we developed a derivative of ts-11 expressing infectious bronchitis virus-S1 glycoprotein (IBV-S1) and releasing chicken interleukin-6 into the extracellular milieu (MG ts-11 C3 (+CS)) using a transposon-based delivery vector. Following administration of MG ts-11 C3 (+CS) to chickens by eye-drop, an antibody response to MG and IBV-S1, as determined by the rapid serum agglutination test (RSA) and Western blotting, respectively, could be detected. Birds inoculated with the recombinant vaccine had significantly enhanced weight gain and were partially protected against damage by pathogenic IBV. These results indicate that the ChIL-6 released by MG ts-11 C3 (+CS) may have had a non-specific effect on growth rate. They also suggest that ts-11 is a promising vaccine vector, capable of delivering heterologous protective antigens, and may also provide non-specific benefits when engineered to express immunomodulatory proteins. With some improvements in the expression system, it could be used to induce a targeted immune response against specific mucosal pathogens, and co-expression of several antigens would allow development of a novel multivalent vaccine. Copyright © 2011 Elsevier Ltd. All rights reserved.

A route to hydroxylfluorenes: TsOH-mediated condensation reactions of 1,3-diketones with propargylic alcohols

KAUST Repository

Yao, Liangfeng; Tan, Davin; Miao, Xiaohe; Huang, Kuo-Wei

2012-01-01

An efficient method of preparing hydroxylfluorenes by TsOH-mediated tandem alkylation/rearrangements of propargylic alcohols with 1,3-diketones is described. These reactions are accomplished in moderate to good yields under mild conditions to offer

Adult-Onset Fluoxetine Treatment Does Not Improve Behavioral Impairments and May Have Adverse Effects on the Ts65Dn Mouse Model of Down Syndrome

Directory of Open Access Journals (Sweden)

Markus Heinen

2012-01-01

Full Text Available Down syndrome is caused by triplication of chromosome 21 and is associated with neurocognitive phenotypes ranging from severe intellectual disability to various patterns of more selective neuropsychological deficits, including memory impairments. In the Ts65Dn mouse model of Down syndrome, excessive GABAergic neurotransmission results in local over-inhibition of hippocampal circuits, which dampens hippocampal synaptic plasticity and contributes to cognitive impairments. Treatments with several GABAA receptor antagonists result in increased plasticity and improved memory deficits in Ts65Dn mice. These GABAA receptor antagonists are, however, not suitable for clinical applications. The selective serotonin reuptake inhibitor fluoxetine, in contrast, is a widely prescribed antidepressant that can also enhance plasticity in the adult rodent brain by lowering GABAergic inhibition. For these reasons, we wondered if an adult-onset 4-week oral fluoxetine treatment restores spatial learning and memory impairments in Ts65Dn mice. Fluoxetine did not measurably improve behavioral impairments of Ts65Dn mice. On the contrary, we observed seizures and mortality in fluoxetine-treated Ts65Dn mice, raising the possibility of a drug × genotype interaction with respect to these adverse treatment outcomes. Future studies should re-address this in larger animal cohorts and determine if fluoxetine treatment is associated with adverse treatment effects in individuals with Down syndrome.

In situ hydrothermal synthesis of a novel hierarchically porous TS-1/modified-diatomite composite for methylene blue (MB) removal by the synergistic effect of adsorption and photocatalysis.

Science.gov (United States)

Yuan, Weiwei; Yuan, Peng; Liu, Dong; Yu, Wenbin; Laipan, Minwang; Deng, Liangliang; Chen, Fanrong

2016-01-15

Hierarchically porous TS-1/modified-diatomite composites with high removal efficiency for methylene blue (MB) were prepared via a facile in situ hydrothermal route. The surface charge state of the diatomite was modified to enhance the electrostatic interactions, followed by in situ hydrothermal coating with TS-1 nanoparticles. The zeolite loading amount in the composites could be adjusted by changing the hydrothermal time. The highest specific surface area and micropore volume of the obtained composites were 521.3m(2)/g and 0.254cm(3)/g, respectively, with an optimized zeolite loading amount of 96.8%. Based on the synergistic effect of efficient adsorption and photocatalysis resulting from the newly formed hierarchically porous structure and improved dispersion of TS-1 nanoparticles onto diatomite, the composites' removal efficiency for MB reached 99.1% after 2h of photocatalytic reaction, even higher than that observed using pure TS-1 nanoparticles. Moreover, the superior MB removal kinetics of the composites were well represented by a pseudo-first-order model, with a rate constant (5.28×10(-2)min(-1)) more than twice as high as that of pure TS-1 nanoparticles (2.43×10(-2)min(-1)). The significant dye removal performance of this novel TS-1/modified-diatomite composite indicates that it is a promising candidate for use in waste water treatment. Copyright © 2015 Elsevier Inc. All rights reserved.

Guidelines: the do's, don'ts and don't knows of feedback for clinical education.

Science.gov (United States)

Lefroy, Janet; Watling, Chris; Teunissen, Pim W; Brand, Paul

2015-12-01

The guidelines offered in this paper aim to amalgamate the literature on formative feedback into practical Do's, Don'ts and Don't Knows for individual clinical supervisors and for the institutions that support clinical learning. The authors built consensus by an iterative process. Do's and Don'ts were proposed based on authors' individual teaching experience and awareness of the literature, and the amalgamated set of guidelines were then refined by all authors and the evidence was summarized for each guideline. Don't Knows were identified as being important questions to this international group of educators which if answered would change practice. The criteria for inclusion of evidence for these guidelines were not those of a systematic review, so indicators of strength of these recommendations were developed which combine the evidence with the authors' consensus. A set of 32 Do and Don't guidelines with the important Don't Knows was compiled along with a summary of the evidence for each. These are divided into guidelines for the individual clinical supervisor giving feedback to their trainee (recommendations about both the process and the content of feedback) and guidelines for the learning culture (what elements of learning culture support the exchange of meaningful feedback, and what elements constrain it?) Feedback is not easy to get right, but it is essential to learning in medicine, and there is a wealth of evidence supporting the Do's and warning against the Don'ts. Further research into the critical Don't Knows of feedback is required. A new definition is offered: Helpful feedback is a supportive conversation that clarifies the trainee's awareness of their developing competencies, enhances their self-efficacy for making progress, challenges them to set objectives for improvement, and facilitates their development of strategies to enable that improvement to occur.

Advisory Material for the IAEA Regulations for the Safe Transport of Radioactive Material (2012 Ed.). Specific Safety Guide

Energy Technology Data Exchange (ETDEWEB)

NONE

2014-06-15

This Safety Guide provides recommendations and guidance on achieving and demonstrating compliance with IAEA Safety Standards Series No. SSR-6, Regulations for the Safe Transport of Radioactive Material (2012 Edition), which establishes the requirements to be applied to the national and international transport of radioactive material. Transport is deemed to comprise all operations and conditions associated with and involved in the movement of radioactive material, including the design, fabrication and maintenance of packaging, and the preparation, consigning, handling, carriage, storage in transit and receipt at the final destination of packages. This publication supersedes IAEA Safety Standards Series No. TS-G-1.1 Rev. 1, which was issued in 2008.

Relationships between divided attention and working memory impairment in people with schizophrenia.

Science.gov (United States)

Gray, Bradley E; Hahn, Britta; Robinson, Benjamin; Harvey, Alex; Leonard, Carly J; Luck, Steven J; Gold, James M

2014-11-01

Recent studies suggest that people with schizophrenia (PSZ) have difficulty distributing their attention broadly. Other research suggests that PSZ have reduced working memory (WM) capacity. This study tested whether these findings reflect a common underlying deficit. We measured the ability to distribute attention by means of the Useful Field of View (UFOV) task, in which participants must distribute attention so that they can discriminate a foveal target and simultaneously localize a peripheral target. Participants included 50 PSZ and 52 healthy control subjects. We found that PSZ exhibited severe impairments in UFOV performance, that UFOV performance was highly correlated with WM capacity in PSZ (r = -.61), and that UFOV impairments could not be explained by either impaired low-level processing or a generalized deficit. These results suggest that a common mechanism explains deficits in the ability to distribute attention broadly, reduced WM capacity, and other aspects of impaired cognition in schizophrenia. We hypothesize that this mechanism may involve abnormal local circuit dynamics that cause a hyperfocusing of resources onto a small number of internal representations. © The Author 2014. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oup.com.

Epigallocatechin-3-gallate (EGCG) consumption in the Ts65Dn model of Down syndrome fails to improve behavioral deficits and is detrimental to skeletal phenotypes.

Science.gov (United States)

Stringer, Megan; Abeysekera, Irushi; Thomas, Jared; LaCombe, Jonathan; Stancombe, Kailey; Stewart, Robert J; Dria, Karl J; Wallace, Joseph M; Goodlett, Charles R; Roper, Randall J

2017-08-01

Down syndrome (DS) is caused by three copies of human chromosome 21 (Hsa21) and results in phenotypes including intellectual disability and skeletal deficits. Ts65Dn mice have three copies of ~50% of the genes homologous to Hsa21 and display phenotypes associated with DS, including cognitive deficits and skeletal abnormalities. DYRK1A is found in three copies in humans with Trisomy 21 and in Ts65Dn mice, and is involved in a number of critical pathways including neurological development and osteoclastogenesis. Epigallocatechin-3-gallate (EGCG), the main polyphenol in green tea, inhibits Dyrk1a activity. We have previously shown that EGCG treatment (~10mg/kg/day) improves skeletal abnormalities in Ts65Dn mice, yet the same dose, as well as ~20mg/kg/day did not rescue deficits in the Morris water maze spatial learning task (MWM), novel object recognition (NOR) or balance beam task (BB). In contrast, a recent study reported that an EGCG-containing supplement with a dose of 2-3mg per day (~40-60mg/kg/day) improved hippocampal-dependent task deficits in Ts65Dn mice. The current study investigated if an EGCG dosage similar to that study would yield similar improvements in either cognitive or skeletal deficits. Ts65Dn mice and euploid littermates were given EGCG [0.4mg/mL] or a water control, with treatments yielding average daily intakes of ~50mg/kg/day EGCG, and tested on the multivariate concentric square field (MCSF)-which assesses activity, exploratory behavior, risk assessment, risk taking, and shelter seeking-and NOR, BB, and MWM. EGCG treatment failed to improve cognitive deficits; EGCG also produced several detrimental effects on skeleton in both genotypes. In a refined HPLC-based assay, its first application in Ts65Dn mice, EGCG treatment significantly reduced kinase activity in femora but not in the cerebral cortex, cerebellum, or hippocampus. Counter to expectation, 9-week-old Ts65Dn mice exhibited a decrease in Dyrk1a protein levels in Western blot analysis

Positron identification by TRDs in TS93 and PAMELA experiments

International Nuclear Information System (INIS)

Bellotti, R.; Cafagna, F.; Castellano, M.; Circella, M.; De Marzo, C.; De Cataldo, G.; Giglietto, N.; Marangelli, B.; Raino, A.; Spinelli, P.

1997-01-01

We are involved in a program to study the antimatter components of the cosmic rays in outer space. We present the performances of a transition radiation detector we have built for positron identification during a balloon flight in 1993. The flight (TS93) was dedicated to the measurement of the positron spectrum in the energy range 4-50 GeV. We present also the design and expected performances of a similar detector we intend to build for a future experiment (PAMELA), to be run on a satellite by the end of 1999, in order to complete this program with higher statistics and at higher energies, namely about 200 GeV. (orig.)

Alignment of CT-PPS detectors in 2016, before TS2

CERN Document Server

Kaspar, J

2017-01-01

This note presents the first alignment of the CMS-TOTEM Precision Proton Spectrometer (CT-PPS) using the data from before Technical Stop 2 (TS2), 2016. This new procedure involves two stages. In the first one, data from a special calibration fill are used. In this fill, both horizontal and vertical Roman Pots (RPs) were inserted very close to the beam. In the second stage, hit distributions from physics fills (with only horizontal RPs inserted) are matched to the previously aligned reference from the calibration fill. The alignment and optics calibration is verified by reconstructing consistent $\\xi$ spectra from different RPs and LHC fills.

Hydraulic and acoustic properties of the active Alpine Fault, New Zealand: Laboratory measurements on DFDP-1 drill core

Science.gov (United States)

Carpenter, B. M.; Kitajima, H.; Sutherland, R.; Townend, J.; Toy, V. G.; Saffer, D. M.

2014-03-01

We report on laboratory measurements of permeability and elastic wavespeed for a suite of samples obtained by drilling across the active Alpine Fault on the South Island of New Zealand, as part of the first phase of the Deep Fault Drilling Project (DFDP-1). We find that clay-rich cataclasite and principal slip zone (PSZ) samples exhibit low permeabilities (⩽10-18 m), and that the permeability of hanging-wall cataclasites increases (from c. 10-18 m to 10-15 m) with distance from the fault. Additionally, the PSZ exhibits a markedly lower P-wave velocity and Young's modulus relative to the wall rocks. Our laboratory data are in good agreement with in situ wireline logging measurements and are consistent with the identification of an alteration zone surrounding the PSZ defined by observations of core samples. The properties of this zone and the low permeability of the PSZ likely govern transient hydrologic processes during earthquake slip, including thermal pressurization and dilatancy strengthening.

Overlapping trisomies for human chromosome 21 orthologs produce similar effects on skull and brain morphology of Dp(16)1Yey and Ts65Dn mice.

Science.gov (United States)

Starbuck, John M; Dutka, Tara; Ratliff, Tabetha S; Reeves, Roger H; Richtsmeier, Joan T

2014-08-01

Trisomy 21 results in gene-dosage imbalance during embryogenesis and throughout life, ultimately causing multiple anomalies that contribute to the clinical manifestations of Down syndrome. Down syndrome is associated with manifestations of variable severity (e.g., heart anomalies, reduced growth, dental anomalies, shortened life-span). Craniofacial dysmorphology and cognitive dysfunction are consistently observed in all people with Down syndrome. Mouse models are useful for studying the effects of gene-dosage imbalance on development. We investigated quantitative changes in the skull and brain of the Dp(16)1Yey Down syndrome mouse model and compared these mice to Ts65Dn and Ts1Cje mouse models. Three-dimensional micro-computed tomography images of Dp(16)1Yey and euploid mouse crania were morphometrically evaluated. Cerebellar cross-sectional area, Purkinje cell linear density, and granule cell density were evaluated relative to euploid littermates. Skulls of Dp(16)1Yey and Ts65Dn mice displayed similar changes in craniofacial morphology relative to their respective euploid littermates. Trisomy-based differences in brain morphology were also similar in Dp(16)1Yey and Ts65Dn mice. These results validate examination of the genetic basis for craniofacial and brain phenotypes in Dp(16)1Yey mice and suggest that they, like Ts65Dn mice, are valuable tools for modeling the effects of trisomy 21 on development. © 2014 Wiley Periodicals, Inc.

Oxidation of Catechol using Titanium Silicate (TS-1 Catalyst: Modeling and Optimization

Directory of Open Access Journals (Sweden)

Sonali Sengupta

2013-12-01

Full Text Available The oxidation of catechol was studied in an eco-friendly process with commercial titanium silicate-1 (TS-1 catalyst and hydrogen peroxide as oxidant in absence of all mass transfer effects. The process was opti-mized by Box-Behnken design in terms of three independent process variables such as reaction tempera-ture, moles of hydrogen peroxide per mole of catechol and catalyst amount whose optimum values of the process variables were found to be 60 °C, 13.2 and 1.24 g respectively for maximum conversion of 75.8 %. The effects of different process parameters such as mole ratio of hydrogen peroxide to catechol, catalyst par-ticle size, catalyst amount, temperature and reaction time were studied. A pseudo first order kinetic model was fitted with the experimental rate data. The apparent activation energy for the reaction was found to be 11.37 kJ/mole.  © 2013 BCREC UNDIP. All rights reservedReceived: 22nd April 2013; Revised: 25th October 2013; Accepted: 1st November 2013[How to Cite: Sengupta, S., Ghosal, D., Basu, J.K. (2013. Oxidation of Catechol using Titanium Silicate (TS-1 Catalyst: Modeling and Optimization. Bulletin of Chemical Reaction Engineering & Catalysis, 8 (2: 167-177. (doi:10.9767/bcrec.8.2.4759.167-177][Permalink/DOI: http://dx.doi.org/10.9767/bcrec.8.2.4759.167-177

Robust fuzzy output feedback controller for affine nonlinear systems via T-S fuzzy bilinear model: CSTR benchmark.

Science.gov (United States)

Hamdy, M; Hamdan, I

2015-07-01

In this paper, a robust H∞ fuzzy output feedback controller is designed for a class of affine nonlinear systems with disturbance via Takagi-Sugeno (T-S) fuzzy bilinear model. The parallel distributed compensation (PDC) technique is utilized to design a fuzzy controller. The stability conditions of the overall closed loop T-S fuzzy bilinear model are formulated in terms of Lyapunov function via linear matrix inequality (LMI). The control law is robustified by H∞ sense to attenuate external disturbance. Moreover, the desired controller gains can be obtained by solving a set of LMI. A continuous stirred tank reactor (CSTR), which is a benchmark problem in nonlinear process control, is discussed in detail to verify the effectiveness of the proposed approach with a comparative study. Copyright © 2014 ISA. Published by Elsevier Ltd. All rights reserved.

MoMuLV-ts-1: A Unique Mouse Model of Retrovirus-Induced Lymphoma Transmitted by Breast Milk

Directory of Open Access Journals (Sweden)

J. Chakraborty

2011-01-01

Full Text Available Our laboratory has developed a murine model of lymphoma via breast milk transmission of MoMuLV-ts-1 (Moloney murine leukemia virus-temperature sensitive mutant-1. Uninfected offspring suckled from infected surrogate mothers become infected and develop lymphoma. Multiple gene integration sites of ts-1 into the infected mouse genome including tacc3, aurka, ndel1, tpx2, p53, and rhamm were identified, and mRNA expressions were quantitated. These genes produce centrosomal proteins, which may be involved in abnormal chromosomal segregation leading to aneuploidy or multiploidy, thus causing lymphoma. Since there is no report to date on this retroviral model leading to centrosomal abnormality, and causing lymphoma development, this is a valuable and unique model to study the centrosomal involvement in lymphomagenesis.

H∞ Filtering for Discrete Markov Jump Singular Systems with Mode-Dependent Time Delay Based on T-S Fuzzy Model

Directory of Open Access Journals (Sweden)

Cheng Gong

2014-01-01

Full Text Available This paper investigates the H∞ filtering problem of discrete singular Markov jump systems (SMJSs with mode-dependent time delay based on T-S fuzzy model. First, by Lyapunov-Krasovskii functional approach, a delay-dependent sufficient condition on H∞-disturbance attenuation is presented, in which both stability and prescribed H∞ performance are required to be achieved for the filtering-error systems. Then, based on the condition, the delay-dependent H∞ filter design scheme for SMJSs with mode-dependent time delay based on T-S fuzzy model is developed in term of linear matrix inequality (LMI. Finally, an example is given to illustrate the effectiveness of the result.

Synthesis and morphology research of framework Ti-rich TS-1 containing no extraframework Ti species in the presence of CO2

KAUST Repository

Zhu, Guowei

2014-02-01

A new method to synthesis TS-1 has been developed using the carbon dioxide (CO2) as an alkalinity regulator that resulted in the increased framework Ti contents. The prepared catalyst had a Si/Ti ratio as low as 40 in contrast to the ratio of 56 prepared through conventional synthesis. The twin crystals with the length of 2 μm were formed via introduction of CO 2. The catalytic activity of TS-1 is remarkably enhanced compared with the conventional synthesis. © 2013 Elsevier B.V.

Event-related brain potential correlates of words' emotional valence irrespective of arousal and type of task.

Science.gov (United States)

Espuny, Javier; Jiménez-Ortega, Laura; Casado, Pilar; Fondevila, Sabela; Muñoz, Francisco; Hernández-Gutiérrez, David; Martín-Loeches, Manuel

2018-03-23

Many Event-Related brain Potential (ERP) experiments have explored how the two main dimensions of emotion, arousal and valence, affect linguistic processing. However, the heterogeneity of experimental paradigms and materials has led to mixed results. In the present study, we aim to clarify words' emotional valence effects on ERP when arousal is controlled, and determine whether these effects may vary as a function of the type of task performed. For these purposes, we designed an ERP experiment with the valence of words manipulated, and arousal equated across valences. The participants performed two types of task: in one, they had to read aloud each word, written in black on a white background; in the other, they had to name the color of the ink in which each word was written. The results showed the main effects of valence irrespective of task, and no interaction between valence and task. The most marked effects of valence were in response to negative words, which elicited an Early Posterior Negativity (EPN) and a Late Positive Complex (LPC). Our results suggest that, when arousal is controlled, the cognitive information in negative words triggers a 'negativity bias', these being the only words able to elicit emotion-related ERP modulations. Moreover, these modulations are largely unaffected by the types of task explored here. Copyright © 2018 Elsevier B.V. All rights reserved.

NeemAzal T/S – toxicity to early-life stages of common carp (Cyprinus carpio L.)

Czech Academy of Sciences Publication Activity Database

Chromcová, L.; Blahová, J.; Živná, D.; Plhalová, L.; Casuscelli di Tocco, F.; Divišová, L.; Prokeš, Miroslav; Faggio, C.; Tichý, F.; Svobodová, Z.

2015-01-01

Roč. 60, č. 1 (2015), s. 23-30 ISSN 0375-8427 Institutional support: RVO:68081766 Keywords : Neemazal T/S * embryo-larval toxicity test * azadirachtin * oxidative stress * histopathology * insecticide Subject RIV: GJ - Animal Vermins ; Diseases, Veterinary Medicine Impact factor: 0.560, year: 2015

Intermittent magnetic reconnection in TS-3 merging experiment

International Nuclear Information System (INIS)

Ono, Y.; Hayashi, Y.; Ii, T.; Tanabe, H.; Ito, S.; Kuwahata, A.; Ito, T.; Kamino, Y.; Yamada, T.; Inomoto, M.

2011-01-01

Ejection of current sheet with plasma mass causes impulsive and intermittent magnetic reconnection in the TS-3 spherical tokamak (ST) merging experiment. Under high guide toroidal field, the sheet resistivity is almost classical due to the sheet thickness much longer than the ion gyroradius. Large inflow flux and low current-sheet resistivity result in flux and plasma pileup followed by rapid growth of the current sheet. When the pileup exceeds a critical limit, the sheet is ejected mechanically from the squeezed X-point area. The reconnection (outflow) speed is slow during the flux/plasma pileup and is fast during the ejection, suggesting that intermittent reconnection similar to the solar flare increases the averaged reconnection speed. These transient effects enable the merging tokamaks to have the fast reconnection as well as the high-power reconnection heating, even when their current-sheet resistivity is low under high guide field.

When does subliminal affective image priming influence the ability of schizophrenic patients to perceive face emotions?

Science.gov (United States)

Vaina, Lucia Maria; Rana, Kunjan D; Cotos, Ionela; Li-Yang, Chen; Huang, Melissa A; Podea, Delia

2014-12-24

Deficits in face emotion perception are among the most pervasive aspects of schizophrenia impairments which strongly affects interpersonal communication and social skills. Schizophrenic patients (PSZ) and healthy control subjects (HCS) performed 2 psychophysical tasks. One, the SAFFIMAP test, was designed to determine the impact of subliminally presented affective or neutral images on the accuracy of face-expression (angry or neutral) perception. In the second test, FEP, subjects saw pictures of face-expression and were asked to rate them as angry, happy, or neutral. The following clinical scales were used to determine the acute symptoms in PSZ: Positive and Negative Syndrome (PANSS), Young Mania Rating (YMRS), Hamilton Depression (HAM-D), and Hamilton Anxiety (HAM-A). On the SAFFIMAP test, different from the HCS group, the PSZ group tended to categorize the neutral expression of test faces as angry and their response to the test-face expression was not influenced by the affective content of the primes. In PSZ, the PANSS-positive score was significantly correlated with correct perception of angry faces for aggressive or pleasant primes. YMRS scores were strongly correlated with PSZ's tendency to recognize angry face expressions when the prime was a pleasant or a neutral image. The HAM-D score was positively correlated with categorizing the test-faces as neutral, regardless of the affective content of the prime or of the test-face expression (angry or neutral). Despite its exploratory nature, this study provides the first evidence that conscious perception and categorization of facial emotions (neutral or angry) in PSZ is directly affected by their positive or negative symptoms of the disease as defined by their individual scores on the clinical diagnostic scales.

Micro-matrix solid-phase dispersion coupled with MEEKC for quantitative analysis of lignans in Schisandrae Chinensis Fructus using molecular sieve TS-1 as a sorbent.

Science.gov (United States)

Chu, Chu; Wei, Mengmeng; Wang, Shan; Zheng, Liqiong; He, Zheng; Cao, Jun; Yan, Jizhong

2017-09-15

A simple and effective method was developed for determining lignans in Schisandrae Chinensis Fructus by using a micro-matrix solid phase dispersion (MSPD) technique coupled with microemulsion electrokinetic chromatography (MEEKC). Molecular sieve, TS-1, was applied as a solid supporting material in micro MSPD extraction for the first time. Parameters that affect extraction efficiency, such as type of dispersant, mass ratio of the sample to the dispersant, grinding time, elution solvent and volume were optimized. The optimal extraction conditions involve dispersing 25mg of powdered Schisandrae samples with 50mg of TS-1 by a mortar and pestle. A grinding time of 150s was adopted. The blend was then transferred to a solid-phase extraction cartridge and the target analytes were eluted with 500μL of methanol. Moreover, several parameters affecting MEEKC separation were studied, including the type of oil, SDS concentration, type and concentration of cosurfactant, and concentration of organic modifier. A satisfactory linearity (R>0.9998) was obtained, and the calculated limits of quantitation were less than 2.77μg/mL. Finally, the micro MSPD-MEEKC method was successfully applied to the analysis of lignans in complex Schisandrae fructus samples. Copyright © 2017 Elsevier B.V. All rights reserved.

Limited OXPHOS capacity in white adipocytes is a hallmark of obesity in laboratory mice irrespective of the glucose tolerance status

Directory of Open Access Journals (Sweden)

Theresa Schöttl

2015-09-01

Conclusion: Reduced mitochondrial respiratory capacity in white adipocytes is a hallmark of murine obesity irrespective of the glucose tolerance status. Impaired respiratory capacity in white adipocytes solely is not sufficient for the development of systemic glucose intolerance.

[Case report: a recurrent gastric cancer in the terminal stage, associated with obstructive jaundice which responded significantly to oral administration of TS-1].

Science.gov (United States)

Tasaka, K; Tomofuzi, Y; Sugihara, Z; Fukuda, H

2001-10-01

TS-1, a novel oral formation of 5-fluorouracil that consists of 1M tegafur (5-FU), 0.4M CDHP and 1M Oxo, is reported to achieve a higher response rate of 49% in patients with advanced gastric cancer in a late phase II study. We report a case of recurrent gastric cancer that responded significantly to the short-term administration of TS-1. A 73-year-old man, who had undergone a curative distal gastrectomy with D2 lymphadenectomy 2 years earlier, had presented with obstructive jaundice resulting from cancerous lymphadenopathy. PTCD was performed for drainage, but cholestasis disappeared completely through the two courses of oral administration of TS-1. The serum level of transaminase and bilirubin remained within normal limits, even with PTCD unequipped, until the patient died of the original disease. The adverse effects observed with the drug were anemia (grade 1) and skin pigmentation (grade 2), both of which improved soon after discontinuing the medication. In conclusion, TS-1 may be well-tolerable and effective in some cases of terminal-stage and/or recurrent gastric cancer, especially those associated with obstructive jaundice arising from the cancerous lymphadenopathy, in that patient QOL can be maintained to a much greater extent.

HAfTs are novel lncRNA transcripts from aflatoxin exposure.

Directory of Open Access Journals (Sweden)

B Alex Merrick

Full Text Available The transcriptome can reveal insights into precancer biology. We recently conducted RNA-Seq analysis on liver RNA from male rats exposed to the carcinogen, aflatoxin B1 (AFB1, for 90 days prior to liver tumor onset. Among >1,000 differentially expressed transcripts, several novel, unannotated Cufflinks-assembled transcripts, or HAfTs (Hepatic Aflatoxin Transcripts were found. We hypothesized PCR-cloning and RACE (rapid amplification of cDNA ends could further HAfT identification. Sanger data was obtained for 6 transcripts by PCR and 16 transcripts by 5'- and 3'-RACE. BLAST alignments showed, with two exceptions, HAfT transcripts were lncRNAs, >200nt without apparent long open reading frames. Six rat HAfT transcripts were classified as 'novel' without RefSeq annotation. Sequence alignment and genomic synteny showed each rat lncRNA had a homologous locus in the mouse genome and over half had homologous loci in the human genome, including at least two loci (and possibly three others that were previously unannotated. While HAfT functions are not yet clear, coregulatory roles may be possible from their adjacent orientation to known coding genes with altered expression that include 8 HAfT-gene pairs. For example, a unique rat HAfT, homologous to Pvt1, was adjacent to known genes controlling cell proliferation. Additionally, PCR and RACE Sanger sequencing showed many alternative splice variants and refinements of exon sequences compared to Cufflinks assembled transcripts and gene prediction algorithms. Presence of multiple splice variants and short tandem repeats found in some HAfTs may be consequential for secondary structure, transcriptional regulation, and function. In summary, we report novel, differentially expressed lncRNAs after exposure to the genotoxicant, AFB1, prior to neoplastic lesions. Complete cloning and sequencing of such transcripts could pave the way for a new set of sensitive and early prediction markers for chemical

Planck 2013 results. XX. Cosmology from Sunyaev-Zeldovich cluster counts

DEFF Research Database (Denmark)

Ade, P. A. R.; Aghanim, N.; Armitage-Caplan, C.

2013-01-01

We present constraints on cosmological parameters using number counts as a function of redshift for a sub-sample of 189 galaxy clusters from the Planck SZ (PSZ) catalogue. The PSZ is selected through the signature of the Sunyaev-Zeldovich (SZ) effect, and the sub-sample used here has a signal-to-...

Planck 2013 results. XXXII. The updated Planck catalogue of Sunyaev-Zeldovich sources

DEFF Research Database (Denmark)

Ade, P. A. R.; Aghanim, N.; Armitage-Caplan, C.

2015-01-01

We update the all-sky Planck catalogue of 1227 clusters and cluster candidates (PSZ1) published in March 2013, derived from detections of the Sunyaev-Zeldovich (SZ) effect using the first 15.5 months of Planck satellite observations. As an addendum, we deliver an updated version of the PSZ1 catal...

Gemcitabine-Based Chemogene Therapy for Pancreatic Cancer Using Ad-dCK::UMK GDEPT and TS/RR siRNA Strategies

Directory of Open Access Journals (Sweden)

Soukaina Réjiba

2009-07-01

Full Text Available Gemcitabine is a first-line agent for advanced pancreatic cancer therapy. However, its efficacy is often limited by its poor intracellular metabolism and chemoresistance. To exert its antitumor activity, gemcitabine requires to be converted to its active triphosphate form. Thus, our aim was to improve gemcitabine activation using gene-directed enzyme prodrug therapy based on gemcitabine association with the deoxycytidine kinase::uridine monophosphate kinase fusion gene (dCK::UMK and small interference RNA directed against ribonucleotide reductase (RRM2 and thymidylate synthase (TS. In vitro, cytotoxicity was assessed by 3-[4,5-dimethylthiazol-2-yl]-3,5-diphenyl tetrazolium bromide and [3H]thymidine assays. Apoptosis-related gene expression and activity were analyzed by reverse transcription-polymerase chain reaction, Western blot, and ELISA. For in vivo studies, the treatment efficacy was evaluated on subcutaneous and orthotopic pancreatic tumor models. Our data indicated that cell exposure to gemcitabine induced a down-regulation of dCK expression and up-regulation of TS and RR expression in Panc1-resistant cells when compared with BxPc3- and HA-hpc2-sensitive cells. The combination of TS/RRM2 small interference RNA with Ad-dCK::UMK induced a 40-fold decrease of gemcitabine IC50 in Panc1 cells. This strong sensitization was associated to apoptosis induction with a remarkable increase in TRAIL expression and a diminution of gemcitabine-induced nuclear factor-κB activity. In vivo, the gemcitabine-based tritherapy strongly reduced tumor volumes and significantly prolonged mice survival. Moreover, we observed an obvious increase of apoptosis and decrease of cell proliferation in tumors receiving the tritherapy regimens. Together, these findings suggest that simultaneous TS/RRM2-gene silencing and dCK::UMK gene overexpression markedly improved gemcitabine's therapeutic activity. Clearly, this combined strategy warrants further investigation.

Impôts en France : réunion publique le mercredi 19 mars 2014

CERN Multimedia

CERN. Geneva

2014-01-01

Impôts en France : réunion publique le mercredi 19 mars 2014 Une réunion publique aura lieu le mercredi 19 mars de 13h à 15h dans l’amphithéâtre principal (500/1-001). Au cours de cette réunion, MM. Jean-Louis Brandolin et Gérard Polizzi, respectivement responsable et responsable-adjoint du Service des impôts des particuliers et des entreprises de Bellegarde, Centre des finances publiques, apporteront leur expertise au sujet de l’imposition des membres du personnel du CERN domiciliés en France. Seront à l’ordre du jour les questions de principe que se posent apparemment de nombreux membres du personnel : par exemple, la définition du domicile fiscal, le contenu de la déclaration de revenus (mention des revenus CERN et déclaration des autres revenus de sources française ou étrangère), la déclaration des comptes bancaires à l’étranger, l’assujettissement (dans certaines conditions) à la CSG-CRDS. Cette réunion publique portera UNIQUEMENT sur des questions de principe ...

The effect of partially stabilized zirconia on the biological properties of HA/HDPE composites in vitro.

Science.gov (United States)

Sadi, A Yari; Shokrgozar, M A; Homaeigohar, S Sh; Hosseinalipour, M; Khavandi, A; Javadpour, J

2006-05-01

The effect of partially stabilized zirconia (PSZ) on the biological properties of the hyroxyapatite - high density polyethylene (HA/HDPE) composites was studied by investigating the simultaneous effect of hydroxyapatite and PSZ volume fractions on the in vitro response of human osteoblast cells. The biocompatibility of composite samples with different volume fraction of HA and PSZ powders was assessed by proliferation, alkaline phosphatase (ALP) and cell attachment assays on the osteoblast cell line (G-292) in different time periods. The effect of composites on the behavior of G-292 cells was compared with those of HDPE and TPS (Tissue Culture Poly Styrene as negative control) samples. Results showed a higher proliferation rate of G-292 cells in the presence of composite samples as compared to the HDPE sample after 7 and 14 days of incubation period. ALP production rate in all composite samples was higher than HDPE and TPS samples. The number of adhered cells on the composite samples was higher than the number adhered on the HDPE and TPS samples after the above mentioned incubation periods. These findings indicates that the addition of PSZ does not have any adverse affect on the biocompatibility of HA/HDPE composites. In fact in some experiments PSZ added HA/HDPE composites performed better in proliferation, differentiation and attachment of osteoblastic cells.

Planck 2013 results. XXXII. The updated Planck catalogue of Sunyaev-Zeldovich sources

Science.gov (United States)

Planck Collaboration; Ade, P. A. R.; Aghanim, N.; Armitage-Caplan, C.; Arnaud, M.; Ashdown, M.; Atrio-Barandela, F.; Aumont, J.; Aussel, H.; Baccigalupi, C.; Banday, A. J.; Barreiro, R. B.; Barrena, R.; Bartelmann, M.; Bartlett, J. G.; Battaner, E.; Benabed, K.; Benoît, A.; Benoit-Lévy, A.; Bernard, J.-P.; Bersanelli, M.; Bielewicz, P.; Bikmaev, I.; Bobin, J.; Bock, J. J.; Böhringer, H.; Bonaldi, A.; Bond, J. R.; Borrill, J.; Bouchet, F. R.; Bridges, M.; Bucher, M.; Burenin, R.; Burigana, C.; Butler, R. C.; Cardoso, J.-F.; Carvalho, P.; Catalano, A.; Challinor, A.; Chamballu, A.; Chary, R.-R.; Chen, X.; Chiang, H. C.; Chiang, L.-Y.; Chon, G.; Christensen, P. R.; Churazov, E.; Church, S.; Clements, D. L.; Colombi, S.; Colombo, L. P. L.; Comis, B.; Couchot, F.; Coulais, A.; Crill, B. P.; Curto, A.; Cuttaia, F.; Da Silva, A.; Dahle, H.; Danese, L.; Davies, R. D.; Davis, R. J.; de Bernardis, P.; de Rosa, A.; de Zotti, G.; Delabrouille, J.; Delouis, J.-M.; Démoclès, J.; Désert, F.-X.; Dickinson, C.; Diego, J. M.; Dolag, K.; Dole, H.; Donzelli, S.; Doré, O.; Douspis, M.; Dupac, X.; Efstathiou, G.; Enßlin, T. A.; Eriksen, H. K.; Feroz, F.; Ferragamo, A.; Finelli, F.; Flores-Cacho, I.; Forni, O.; Frailis, M.; Franceschi, E.; Fromenteau, S.; Galeotta, S.; Ganga, K.; Génova-Santos, R. T.; Giard, M.; Giardino, G.; Gilfanov, M.; Giraud-Héraud, Y.; González-Nuevo, J.; Górski, K. M.; Grainge, K. J. B.; Gratton, S.; Gregorio, A.; Groeneboom, N., E.; Gruppuso, A.; Hansen, F. K.; Hanson, D.; Harrison, D.; Hempel, A.; Henrot-Versillé, S.; Hernández-Monteagudo, C.; Herranz, D.; Hildebrandt, S. R.; Hivon, E.; Hobson, M.; Holmes, W. A.; Hornstrup, A.; Hovest, W.; Huffenberger, K. M.; Hurier, G.; Hurley-Walker, N.; Jaffe, A. H.; Jaffe, T. R.; Jones, W. C.; Juvela, M.; Keihänen, E.; Keskitalo, R.; Khamitov, I.; Kisner, T. S.; Kneissl, R.; Knoche, J.; Knox, L.; Kunz, M.; Kurki-Suonio, H.; Lagache, G.; Lähteenmäki, A.; Lamarre, J.-M.; Lasenby, A.; Laureijs, R. J.; Lawrence, C. R.; Leahy, J. P.; Leonardi, R.; León-Tavares, J.; Lesgourgues, J.; Li, C.; Liddle, A.; Liguori, M.; Lilje, P. B.; Linden-Vørnle, M.; López-Caniego, M.; Lubin, P. M.; Macías-Pérez, J. F.; MacTavish, C. J.; Maffei, B.; Maino, D.; Mandolesi, N.; Maris, M.; Marshall, D. J.; Martin, P. G.; Martínez-González, E.; Masi, S.; Massardi, M.; Matarrese, S.; Matthai, F.; Mazzotta, P.; Mei, S.; Meinhold, P. R.; Melchiorri, A.; Melin, J.-B.; Mendes, L.; Mennella, A.; Migliaccio, M.; Mikkelsen, K.; Mitra, S.; Miville-Deschênes, M.-A.; Moneti, A.; Montier, L.; Morgante, G.; Mortlock, D.; Munshi, D.; Murphy, J. A.; Naselsky, P.; Nastasi, A.; Nati, F.; Natoli, P.; Nesvadba, N. P. H.; Netterfield, C. B.; Nørgaard-Nielsen, H. U.; Noviello, F.; Novikov, D.; Novikov, I.; O'Dwyer, I. J.; Olamaie, M.; Osborne, S.; Oxborrow, C. A.; Paci, F.; Pagano, L.; Pajot, F.; Paoletti, D.; Pasian, F.; Patanchon, G.; Pearson, T. J.; Perdereau, O.; Perotto, L.; Perrott, Y. C.; Perrotta, F.; Piacentini, F.; Piat, M.; Pierpaoli, E.; Pietrobon, D.; Plaszczynski, S.; Pointecouteau, E.; Polenta, G.; Ponthieu, N.; Popa, L.; Poutanen, T.; Pratt, G. W.; Prézeau, G.; Prunet, S.; Puget, J.-L.; Rachen, J. P.; Reach, W. T.; Rebolo, R.; Reinecke, M.; Remazeilles, M.; Renault, C.; Ricciardi, S.; Riller, T.; Ristorcelli, I.; Rocha, G.; Rosset, C.; Roudier, G.; Rowan-Robinson, M.; Rubiño-Martín, J. A.; Rumsey, C.; Rusholme, B.; Sandri, M.; Santos, D.; Saunders, R. D. E.; Savini, G.; Schammel, M. P.; Scott, D.; Seiffert, M. D.; Shellard, E. P. S.; Shimwell, T. W.; Spencer, L. D.; Starck, J.-L.; Stolyarov, V.; Stompor, R.; Streblyanska, A.; Sudiwala, R.; Sunyaev, R.; Sureau, F.; Sutton, D.; Suur-Uski, A.-S.; Sygnet, J.-F.; Tauber, J. A.; Tavagnacco, D.; Terenzi, L.; Toffolatti, L.; Tomasi, M.; Tramonte, D.; Tristram, M.; Tucci, M.; Tuovinen, J.; Türler, M.; Umana, G.; Valenziano, L.; Valiviita, J.; Van Tent, B.; Vibert, L.; Vielva, P.; Villa, F.; Vittorio, N.; Wade, L. A.; Wandelt, B. D.; White, M.; White, S. D. M.; Yvon, D.; Zacchei, A.; Zonca, A.

2015-09-01

We update the all-sky Planck catalogue of 1227 clusters and cluster candidates (PSZ1) published in March 2013, derived from detections of the Sunyaev-Zeldovich (SZ) effect using the first 15.5 months of Planck satellite observations. As an addendum, we deliver an updated version of the PSZ1 catalogue, reporting the further confirmation of 86 Planck-discovered clusters. In total, the PSZ1 now contains 947 confirmed clusters, of which 214 were confirmed as newly discovered clusters through follow-up observations undertaken by the Planck Collaboration. The updated PSZ1 contains redshifts for 913 systems, of which 736 (~ 80.6%) are spectroscopic, and associated mass estimates derived from the Yz mass proxy. We also provide a new SZ quality flag for the remaining 280 candidates. This flag was derived from a novel artificial neural-network classification of the SZ signal. Based on this assessment, the purity of the updated PSZ1 catalogue is estimated to be 94%. In this release, we provide the full updated catalogue and an additional readme file with further information on the Planck SZ detections. The catalogue is only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (ftp://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/581/A14

Goûts, odeurs et perception relatifs à la qualité de l'eau potable : une perspective spatio-temporelle

OpenAIRE

Proulx, François

2009-01-01

Cette thèse porte sur l'étude des goûts, odeurs et la perception relative à l'eau potable. Le cas à l'étude est l'eau distribuée dans un réseau d'aqueduc de la Ville de Québec. La thèse est divisée en quatre volets. Le premier volet fait la revue de la problématique des composés responsables des goûts et odeurs en réseau de distribution. Plus spécifiquement, les aspects concernant l'origine de ces composés et leurs analyses physico-chimiques et sensorielles sont abordés. Le second chapitre tr...

Disturbance observer-based L1 robust tracking control for hypersonic vehicles with T-S disturbance modeling

Directory of Open Access Journals (Sweden)

Yang Yi

2016-11-01

Full Text Available This article concerns a disturbance observer-based L1 robust anti-disturbance tracking algorithm for the longitudinal models of hypersonic flight vehicles with different kinds of unknown disturbances. On one hand, by applying T-S fuzzy models to represent those modeled disturbances, a disturbance observer relying on T-S disturbance models can be constructed to track the dynamics of exogenous disturbances. On the other hand, L1 index is introduced to analyze the attenuation performance of disturbance for those unmodeled disturbances. By utilizing the existing convex optimization algorithm, a disturbance observer-based proportional-integral-controlled input is proposed such that the stability of hypersonic flight vehicles can be ensured and the tracking error for velocity and altitude in hypersonic flight vehicle models can converge to equilibrium point. Furthermore, the satisfactory disturbance rejection and attenuation with L1 index can be obtained simultaneously. Simulation results on hypersonic flight vehicle models can reflect the feasibility and effectiveness of the proposed control algorithm.

Deformation of footwall rock of Phulad Shear Zone, Rajasthan ...

Indian Academy of Sciences (India)

Phulad Shear Zone (PSZ) of Delhi Fold Belt in Rajasthan is a northeasterly striking ductile shear zone with a well developed mylonitic foliation (035/70E) and a downdip stretching lineation. The deformation in the PSZ has developed in a transpressional regime with thrusting sense of movement. The northeastern unit, i.e. ...

Long-term effect of neonatal inhibition of APP gamma-secretase on hippocampal development in the Ts65Dn mouse model of Down syndrome.

Science.gov (United States)

Stagni, Fiorenza; Raspanti, Alessandra; Giacomini, Andrea; Guidi, Sandra; Emili, Marco; Ciani, Elisabetta; Giuliani, Alessandro; Bighinati, Andrea; Calzà, Laura; Magistretti, Jacopo; Bartesaghi, Renata

2017-07-01

Neurogenesis impairment is considered a major determinant of the intellectual disability that characterizes Down syndrome (DS), a genetic condition caused by triplication of chromosome 21. Previous evidence obtained in the Ts65Dn mouse model of DS showed that the triplicated gene APP (amyloid precursor protein) is critically involved in neurogenesis alterations. In particular, excessive levels of AICD (amyloid precursor protein intracellular domain) resulting from APP cleavage by gamma-secretase increase the transcription of Ptch1, a Sonic Hedgehog (Shh) receptor that keeps the mitogenic Shh pathway repressed. Previous evidence showed that neonatal treatment with ELND006, an inhibitor of gamma-secretase, reinstates the Shh pathway and fully restores neurogenesis in Ts65Dn pups. In the framework of potential therapies for DS, it is extremely important to establish whether the positive effects of early intervention are retained after treatment cessation. Therefore, the goal of the current study was to establish whether early treatment with ELND006 leaves an enduring trace in the brain of Ts65Dn mice. Ts65Dn and euploid pups were treated with ELND006 in the postnatal period P3-P15 and the outcome of treatment was examined at ~one month after treatment cessation. We found that in treated Ts65Dn mice the pool of proliferating cells in the hippocampal dentate gyrus (DG) and total number of granule neurons were still restored as was the number of pre- and postsynaptic terminals in the stratum lucidum of CA3, the site of termination of the mossy fibers from the DG. Accordingly, patch-clamp recording from field CA3 showed functional normalization of the input to CA3. Unlike in field CA3, the number of pre- and postsynaptic terminals in the DG of treated Ts65Dn mice was no longer fully restored. The finding that many of the positive effects of neonatal treatment were retained after treatment cessation provides proof of principle demonstration of the efficacy of early

A novel method of TVTS in the TS-3 device and the proposal of its application to a large device

International Nuclear Information System (INIS)

Tokimatsu, K.; Hayashi, N.; Ueda, Y.; Ono, Y.; Katsurai, M.

1997-01-01

A novel method of television Thomson scattering (TVTS) has been developed in the TS-3 device. In this system, a framing camera is located between a spectroscope and a close coupled device camera. This framing camera can take two successive frames from the exit of the spectroscope. The time interval is of 500 ns between those two frames. Because of the shortness of this time interval, the background light is negligible; moreover TVTS is applicable to the TS-3 device whose plasma lifetime is about 150 μs. This method indicates the possibility of not only high spatial resolution but also time repetition in a simple system. (orig.)

Enhancement by Nalidixic Acid of the Thermal Susceptibility of the Ts-7 Mutant of Escherichia Coli TAU-Bar

Science.gov (United States)

Nishida, Mikio; Mishima, Yukio; Kawada, Jun; Yielding, K. Lemone

1975-01-01

Nadilidixic acid at 5 × 10−6 M produced a substantial increase in thermal susceptibility of Ts-7, suggesting either that the thermal and nalidixic acid targets are identical or closely interdependent. PMID:1101825

Benefits and Factors Influencing the Design of Intergenerational Digital Games: A Systematic Literature Review

NARCIS (Netherlands)

de la Hera Conde-Pumpido, T.; Loos, E.F.; Simons, M.; Blom, J.

2017-01-01

The main purpose of this paper is to review the benefits and factors to be taken into consideration for the design of intergenerational digital games. We conducted a systematic in Scopus, Web of Science, PsicInfo, Pubmed and Science Direct, finally including 16 empirical studies written in English.

Efficient and Stable CsPbBr3 Quantum-Dot Powders Passivated and Encapsulated with a Mixed Silicon Nitride and Silicon Oxide Inorganic Polymer Matrix.

Science.gov (United States)

Yoon, Hee Chang; Lee, Soyoung; Song, Jae Kyu; Yang, Heesun; Do, Young Rag

2018-04-11

Despite the excellent optical features of fully inorganic cesium lead halide (CsPbX 3 ) perovskite quantum dots (PeQDs), their unstable nature has limited their use in various optoelectronic devices. To mitigate the instability issues of PeQDs, we demonstrate the roles of dual-silicon nitride and silicon oxide ligands of the polysilazane (PSZ) inorganic polymer to passivate the surface defects and form a barrier layer coated onto green CsPbBr 3 QDs to maintain the high photoluminescence quantum yield (PLQY) and improve the environmental stability. The mixed SiN x /SiN x O y /SiO y passivated and encapsulated CsPbBr 3 /PSZ core/shell composite can be prepared by a simple hydrolysis reaction involving the addition of adding PSZ as a precursor and a slight amount of water into a colloidal CsPbBr 3 QD solution. The degree of the moisture-induced hydrolysis reaction of PSZ can affect the compositional ratio of SiN x , SiN x O y , and SiO y liganded to the surfaces of the CsPbBr 3 QDs to optimize the PLQY and the stability of CsPbBr 3 /PSZ core/shell composite, which shows a high PLQY (∼81.7%) with improved thermal, photo, air, and humidity stability as well under coarse conditions where the performance of CsPbBr 3 QDs typically deteriorate. To evaluate the suitability of the application of the CsPbBr 3 /PSZ powder to down-converted white-light-emitting diodes (DC-WLEDs) as the backlight of a liquid crystal display (LCD), we fabricated an on-package type of tricolor-WLED by mixing the as-synthesized green CsPbBr 3 /PSZ composite powder with red K 2 SiF 6 :Mn 4+ phosphor powder and a poly(methyl methacrylate)-encapsulating binder and coating this mixed paste onto a cup-type blue LED. The fabricated WLED show high luminous efficacy of 138.6 lm/W (EQE = 51.4%) and a wide color gamut of 128% and 111% without and with color filters, respectively, at a correlated color temperature of 6762 K.

The use of chloroaluminium phthalocyanine tetrasulfonate (AlPcTS) for time-delayed fluorescence imaging

International Nuclear Information System (INIS)

Gundy, Sarah; Putten, Wil van der; Shearer, Andy; Buckton, Daniel; Ryder, Alan G; Ball, Michael

2004-01-01

Phthalocyanine derivatives are currently under investigation for use in photodynamic therapy, which is a promising cancer treatment. These materials, which display preferential uptake in cancerous cells, also exhibit high fluorescence yields and can be used for tumour detection. Problems with steady-state fluorescence techniques such as excitation scatter and background autofluorescence can be eliminated by using time-resolved imaging techniques without the need for filters. A tissue phantom was assembled to test a constructed time-gated imaging system by drilling 36 wells of varying diameter and depth (10 mm to 1 mm) into a block of polymethyl methacrylate (PMMA). The system was used to record images of chloroaluminium phthalocyanine tetrasulfonate (AlPcTS) at differing concentrations in neat aqueous solvent and cell suspensions within the wells. A mixture of Intralipid (to mimic tissue scatter) and Evan's blue (to mimic tissue absorption) of depths ranging from 1 mm to 10 mm was placed on top of the PMMA block. The ensuing images were analysed using signal-to-noise ratios and contrast-detail curves. The results indicate that the time-gated imaging system can prevent background excitation scatter from distorting the fluorescence signal from a longer-lived photosensitizer without the need for filters

Diamond-like carbon coatings enhance scratch resistance of bearing surfaces for use in joint arthroplasty: hard substrates outperform soft.

Science.gov (United States)

Roy, Marcel E; Whiteside, Leo A; Katerberg, Brian J

2009-05-01

The purpose of this study was to test the hypotheses that diamond-like carbon (DLC) coatings will enhance the scratch resistance of a bearing surface in joint arthroplasty, and that a hard ceramic substrate will further enhance scratch resistance by reducing plastic deformation. We tested these hypotheses by applying a hard DLC coating to medical-grade cobalt chromium alloy (CoCr) and magnesia-stabilized zirconia (Mg-PSZ) femoral heads and performing scratch tests to determine the loads required to cause cohesive and adhesive fracture of the coating. Scratch tracks of DLC-coated and noncoated heads were then scanned by optical profilometry to determine scratch depth, width, and pile-up (raised edges), as measures of susceptibility to scratching. DLC-coated CoCr specimens exhibited cohesive coating fracture as wedge spallation at an average load of 9.74 N, whereas DLC-coated Mg-PSZ exhibited cohesive fracture as arc-tensile cracks and chipping at a significantly higher average load of 41.3 N (p coating fracture, DLC-CoCr delaminated at an average load of 35.2 N, whereas DLC-Mg-PSZ fractured by recovery spallation at a significantly higher average load of 46.8 N (p DLC-CoCr and DLC-Mg-PSZ specimens exhibited significantly shallower scratches and less pile-up than did uncoated specimens (p DLC-Mg-PSZ better resisted plastic deformation, requiring significantly higher loads for cohesive and adhesive coating fracture. These findings supported both of our hypotheses. (c) 2008 Wiley Periodicals, Inc.

Delay-Dependent Finite-Time H∞ Controller Design for a Kind of Nonlinear Descriptor Systems via a T-S Fuzzy Model

Directory of Open Access Journals (Sweden)

Baoyan Zhu

2015-01-01

Full Text Available Delay-dependent finite-time H∞ controller design problems are investigated for a kind of nonlinear descriptor system via a T-S fuzzy model in this paper. The solvable conditions of finite-time H∞ controller are given to guarantee that the loop-closed system is impulse-free and finite-time bounded and holds the H∞ performance to a prescribed disturbance attenuation level γ. The method given is the ability to eliminate the impulsive behavior caused by descriptor systems in a finite-time interval, which confirms the existence and uniqueness of solutions in the interval. By constructing a nonsingular matrix, we overcome the difficulty that results in an infeasible linear matrix inequality (LMI. Using the FEASP solver and GEVP solver of the LMI toolbox, we perform simulations to validate the proposed methods for a nonlinear descriptor system via the T-S fuzzy model, which shows the application of the T-S fuzzy method in studying the finite-time control problem of a nonlinear system. Meanwhile the method was also applied to the biological economy system to eliminate impulsive behavior at the bifurcation value, stabilize the loop-closed system in a finite-time interval, and achieve a H∞ performance level.

A comparative analysis of immunorestoration and recovery with conventional and immunotherapeutic protocols in canine generalized demodicosis: a newer insight of immunotherapeutic efficacy of T11TS.

Science.gov (United States)

Sarkar, P; Mukherjee, J; Ghosh, A; Bhattacharjee, M; Mahato, S; Chakraborty, A; Mondal, M; Banerjee, C; Chaudhuri, Swapna

2004-01-01

Demodex canis is a natural inhabiting mite of canine skin. Immunological disorder or genetic disorder induces the Demodex population to proliferate vigorously resulting in generalized demodicosis with consequent chronic immunosuppression. Signs of generalized demodicosis include alopecia, crysting, erythema, secondary pyoderma etc. Amitraz, an acaricide, is used conventionally for the treatment of generalized demodicosis. In many instances, the disease relapses due to the residual immunosuppression. The need of an immunorestorative therapy has been urged in generalized demodicosis. Two immunorestorative drugs, namely, Immuplus, a herbal drug, and T11TS, a sheep erythrocyte surface glycoprotein, has been used in two separate groups of dogs having generalized demodicosis and receiving Amitraz treatment. It was observed that though Amitraz treated group responded to the therapy showing increased E-rosettes and nonspecific cytotoxic efficacy of T-lymphocytes and decrease in phagocytic potential of macrophages, the groups treated with the immunotherapeutics like Immuplus and T11TS, responded better. However, the group treated with T11TS showed best recovery. These results emphasize the need for an immunorestorative therapy in generalized demodicosis and provide data in favor of T11TS as a better immunomodulator in comparison to Immuplus.

Psychometric properties of the Portuguese version of the Acceptance and Action Questionnaire-Trauma Specific (AAQ-TS): A study with Portuguese Colonial War Veterans.

Science.gov (United States)

Pinto-Gouveia, José; Carvalho, Teresa; Cunha, Marina; Duarte, Joana; Walser, Robyn D

2015-10-01

The Acceptance and Action Questionnaire-Trauma Specific (AAQ-TS) is a self-report measure designed to assess-trauma-related psychological (in)flexibility, as conceptualized in Acceptance and Commitment Therapy. However, there are no studies to date regarding its psychometric properties. This study explores such properties in the Portuguese version of the AAQ-TS, in Portuguese Colonial War Veterans. A Principal Components Analysis (PCA) was conducted in a sample from the general population of war Veterans (N=371). Confirmatory Factor Analysis (CFA) as well as reliability and convergent validity studies were performed in a different sample from the same population (N=312). For the discriminant validity a clinical sample with a war-related PTSD (N=42) and a non-clinical sample without PTSD (N=44) were used. The CFA suggested a re-specified 15-item model with good global adjustment and factorial validity. The AAQ-TS showed internal consistency, a good temporal reliability, convergent validity with psychopathological symptoms (related to PTSD, anxiety, depression and stress) and peritraumatic dissociation (altered awareness and depersonalization/derealization). The questionnaire also discriminates between war Veterans with and without a PTSD diagnosis. The major limitation relates to the samples' characteristics and sampling methods, which can limit the generalization of results. The Portuguese version of the AAQ-TS is a reliable and valid measure to assess experiential avoidance related to trauma in Portuguese Colonial War Veterans. Copyright © 2015 Elsevier B.V. All rights reserved.

PENGENDALIAN KUALITAS PT AHM DENGAN MENGGUNAKAN ISO/TS 16949: 2002 UNTUK MENCEGAH KOMPONEN VALVE INLET BENGKOK PADA MOTOR SUPRA KHUSUSNYA MESIN NF100 (Studi Kasus Valve Inlet Bengkok di PT Astra Honda Motor

Directory of Open Access Journals (Sweden)

Naniek Utami Handayani

2012-02-01

Full Text Available Untuk memenuhi keinginan konsumen dalam hal mutu dan jumlah, PT AHM telah menerapkan ISO 9001:2000 (International Standard Organization versi tahun 2000, SIX SIGMA dan ISO/TS 16949:2002 untuk menangani customer claim dan memperbaiki mutu supplier yang ada. Sebelum penerapan ISO/TS 16949:2002, untuk keharmonisan kualitas supplier/penyalur tersebut, PT AHM telah menggunakan QS-9000 dalam mengendalikan kualitas produknya. Berhubung QS-9000 tidak diperbaharui lagi dan hanya akan berlaku sampai tahun 2006, maka sebagai gantinya perusahaan mengambil kebijakan untuk menerapkan ISO/TS 16949:2002 dan menyertakan dalam keseluruhannya kebutuhan ISO 9001:2000. Dari beberapa jenis motor yang diproduksi pada pabrik II dari PT AHM, jenis motor yang diproduksi adalah Legenda, Tiger, GL Max, Mega Pro dan Supra. Diantara kelima motor tersebut, Supra mempunyai prosentase permintaan yang paling tinggi dan juga sekaligus market claim tertingggi (periode Agustus s/d Desember 2004, yaitu sebesar 2,7%, sedangkan berdasarkan penelitian terhadap banyaknya claim customer terhadap komponen motor Supra periode Agustus s/d Desember 2004, claim terhadap komponen  terbesar mencapai 337 claim dari total 1440 claim. Komponen  motor Supra yang dimaksud disini adalah Valve Inlet. Dalam penelitian ini, dievaluasi hasil dari pelaksanaan persiapan penerapan ISO/TS 16949:2002 sebagai teknik pengendalian kualitas terbaru yang telah dipilih dengan menggunakan tools dari ISO/TS 16949:2002 yaitu SPC, FMEA dan Corrective Action. Hasil penelitian ini menunjukkan bahwa penyebab Valve Inlet bengkok bukan hanya berasal dari Valve inlet itu sendiri, melainkan juga sebagai akibat dari adanya ketidaksesuaian pada Guide Valve Inlet dan Cylinder head. Dari penelitian penerapan ISO/TS 16949:2002 di PT AHM dapat diketahui beberapa manfaat ISO/TS 16949:2002 dalam mengendalikan kualitas produk dan memenuhi kebutuhan customer. Kata Kunci: Market Claim, Customer Claim, ISO/TS 16949:2002, SPC, FMEA dan

Molecular Cloning of a cDNA Encoding for Taenia solium TATA-Box Binding Protein 1 (TsTBP1) and Study of Its Interactions with the TATA-Box of Actin 5 and Typical 2-Cys Peroxiredoxin Genes.

Science.gov (United States)

Rodríguez-Lima, Oscar; García-Gutierrez, Ponciano; Jiménez, Lucía; Zarain-Herzberg, Ángel; Lazzarini, Roberto; Landa, Abraham

2015-01-01

TATA-box binding protein (TBP) is an essential regulatory transcription factor for the TATA-box and TATA-box-less gene promoters. We report the cloning and characterization of a full-length cDNA that encodes a Taenia solium TATA-box binding protein 1 (TsTBP1). Deduced amino acid composition from its nucleotide sequence revealed that encodes a protein of 238 residues with a predicted molecular weight of 26.7 kDa, and a theoretical pI of 10.6. The NH2-terminal domain shows no conservation when compared with to pig and human TBP1s. However, it shows high conservation in size and amino acid identity with taeniids TBP1s. In contrast, the TsTBP1 COOH-terminal domain is highly conserved among organisms, and contains the amino acids involved in interactions with the TATA-box, as well as with TFIIA and TFIIB. In silico TsTBP1 modeling reveals that the COOH-terminal domain forms the classical saddle structure of the TBP family, with one α-helix at the end, not present in pig and human. Native TsTBP1 was detected in T. solium cysticerci´s nuclear extract by western blot using rabbit antibodies generated against two synthetic peptides located in the NH2 and COOH-terminal domains of TsTBP1. These antibodies, through immunofluorescence technique, identified the TBP1 in the nucleus of cells that form the bladder wall of cysticerci of Taenia crassiceps, an organism close related to T. solium. Electrophoretic mobility shift assays using nuclear extracts from T. solium cysticerci and antibodies against the NH2-terminal domain of TsTBP1 showed the interaction of native TsTBP1 with the TATA-box present in T. solium actin 5 (pAT5) and 2-Cys peroxiredoxin (Ts2-CysPrx) gene promoters; in contrast, when antibodies against the anti-COOH-terminal domain of TsTBP1 were used, they inhibited the binding of TsTBP1 to the TATA-box of the pAT5 promoter gene.

Touchscreen learning deficits in Ube3a, Ts65Dn and Mecp2 mouse models of neurodevelopmental disorders with intellectual disabilities.

Science.gov (United States)

Leach, P T; Crawley, J N

2017-12-20

Mutant mouse models of neurodevelopmental disorders with intellectual disabilities provide useful translational research tools, especially in cases where robust cognitive deficits are reproducibly detected. However, motor, sensory and/or health issues consequent to the mutation may introduce artifacts that preclude testing in some standard cognitive assays. Touchscreen learning and memory tasks in small operant chambers have the potential to circumvent these confounds. Here we use touchscreen visual discrimination learning to evaluate performance in the maternally derived Ube3a mouse model of Angelman syndrome, the Ts65Dn trisomy mouse model of Down syndrome, and the Mecp2 Bird mouse model of Rett syndrome. Significant deficits in acquisition of a 2-choice visual discrimination task were detected in both Ube3a and Ts65Dn mice. Procedural control measures showed no genotype differences during pretraining phases or during acquisition. Mecp2 males did not survive long enough for touchscreen training, consistent with previous reports. Most Mecp2 females failed on pretraining criteria. Significant impairments on Morris water maze spatial learning were detected in both Ube3a and Ts65Dn, replicating previous findings. Abnormalities on rotarod in Ube3a, and on open field in Ts65Dn, replicating previous findings, may have contributed to the observed acquisition deficits and swim speed abnormalities during water maze performance. In contrast, these motor phenotypes do not appear to have affected touchscreen procedural abilities during pretraining or visual discrimination training. Our findings of slower touchscreen learning in 2 mouse models of neurodevelopmental disorders with intellectual disabilities indicate that operant tasks offer promising outcome measures for the preclinical discovery of effective pharmacological therapeutics. © 2017 John Wiley & Sons Ltd and International Behavioural and Neural Genetics Society.

A virtual computing infrastructure for TS-CV SCADA systems

CERN Document Server

Poulsen, S

2008-01-01

In modern data centres, it is an emerging trend to operate and manage computers as software components or logical resources and not as physical machines. This technique is known as â€ﾜvirtualisation” and the new computers are referred to as â€ﾜvirtual machines” (VMs). Multiple VMs can be consolidated on a single hardware platform and managed in ways that are not possible with physical machines. However, this is not yet widely practiced for control system deployment. In TS-CV, a collection of VMs or a â€ﾜvirtual infrastructure” is installed since 2005 for SCADA systems, PLC program development, and alarm transmission. This makes it possible to consolidate distributed, heterogeneous operating systems and applications on a limited number of standardised high-performance servers in the Central Control Room (CCR). More generally, virtualisation assists in offering continuous computing services for controls and maintaining performance and assuring quality. Implementing our systems in a vi...

Rheological online determination of the organic dry substance concentration of sewage sludge; Rheologische online Bestimmung des oTS-Gehalts von Klaerschlamm

Energy Technology Data Exchange (ETDEWEB)

Schmitz, P.; Boehm, A.; Fessler, J.; Liebelt, U. [BASF AG, Ludwigshafen am Rhein (Germany); Traegner, U. [Fachhochschule fuer Technik, Mannheim (Germany)

1999-07-01

In order to adjust the filter cake to a certain calorific value and to enhance the dehydratability of sludge, ash, carbon and flocculation agents are added to the latter prior to filtration. Dosage of the additives depends on the sludge's content of organic solids, determined in the form of the so-called organic dry substance concentration. In bench-scale and technical-scale experiments on the rheological properties of sewage sludge, a correlation between organic dry substance concentration and rheological properties, especially the liquid limit of sewage sludge, was established. This knowledge was used to develop a measuring technique for online determination of organic dry substance concentration by means of rheology. (orig.) [German] Zur Einstellung eines bestimmten Heizwertes des Filterkuchens und zur Verbesserung der Entwaesserbarkeit werden dem Schlamm vor der Filtration Asche, Kohle und Flockungsmittel zugegeben. Die Dosierung der Zuschlagsstoffe erfolgt in Abhaengigkeit vom Gehalt des Schlamms an organischem Feststoff, bestimmt in Form der sog. oTS-Konzentration. In Labor- und Betriebsversuchen zum rheologischen Verhalten von Klaerschlamm konnte eine Korrelation zwischen der oTS-Konzentration und den Fliesseigenschaften, insbesondere der Fliessgrenze von Klaerschlamm ermittelt werden. Diese Erkenntnis wurde in ein Messverfahren zur online-Bestimmung der oTS-Konzentration mittels Rheologie umgesetzt. (orig.)

High-temperature deformation of SiC-whisker-reinforced MgO-PSZ/mullite composites

International Nuclear Information System (INIS)

Parthasarathy, T.A.; Hay, R.S.; Ruh, R.

1996-01-01

The effect of 33.5 vol% SiC whisker loading on high-temperature deformation of 1 wt% MgO-38.5 wt% zirconia-mullite composites was studied between 1,300 and 1,400 C. At strain rates of 10 -6 to 5 x 10 -4 /s the creep resistance of zirconia-mullite composites without SiC reinforcement was inferior to monolithic mullite of similar grain size. Analysis of the results suggested that the decreased creep resistance of mullite-zirconia composites compared to pure mullite could be at least partially explained by mechanical effects of the weaker zirconia phase, increased effective diffusivity of mullite by zirconia addition, and to the differences in mullite grain morphology. With SiC whisker reinforcement, the deformation rate at high stress was nearly the same as that of the unreinforced material, but at low stress the creep rates of the SiC-reinforced material were significantly lowered. The stress dependence of the creep rate of unreinforced material suggested that diffusional creep was the operative mechanism, while the reinforced material behaved as if a threshold stress for creep existed. The threshold stress could be rationalized based on a whisker network model. This was supported by data on other whisker-containing materials; however, the threshold stress had a temperature dependence that was orders of magnitude higher than the elastic constants, leaving the physical model incomplete. The effects of residual stresses and amorphous phases at whisker/matrix interfaces are invoked to help complete the physical model for creep threshold stress

FY 2000 report on the results of the research and development project for new industry creation type industrial science technologies. R and D of the intellectual material and structural systems (R and D of the intellectual material and structural systems); 2000 nendo shinki sangyo soshutsugata sangyo kagaku gijutsu kenkyu kaihatsu seika hokokusho. Chiteki kozo system no kenkyu kaihatsu (chiteki kozo system no kenkyu kaihatsu)

Energy Technology Data Exchange (ETDEWEB)

NONE

2001-03-01

Described herein are the FY 2000 results of the R and D project for development of intellectual materials and structural systems, where the fibrous or leafy sensor material or element (muscle) is integrated with a structure of an advanced material (skeleton) to process and control information (brain). The program for development of the health monitoring technologies successfully improves the fine FRG (Fiber Bragg Grating) as the high-performance sensor, equipped with a connector which allows the sensor to be easily connected to the normal diameter one, and develops various prototype sensors. The program for self-diagnosis of structural soundness and controlling damages verifies detection effectiveness of the embedded fine FRG sensor. The impact-related characteristics and damages of the reinforced flat plate are detected by embedding the optical fiber sensor. The program for developing the actuator materials and elements prepares the 20{mu}m thick piezoelectric sheet of adequate strength and toughness by dispersing the PNN-PZT system with partially stabilized zirconia (PSZ). The program for the function-gradient systems prepares the FGM driven at normal temperature, characterized by its structure of more evenly distributed stress, to evaluate its characteristics. It is proved to have high durability. The results of the comprehensive survey are also described. (NEDO)

High precision wavelength measurements of X-ray lines emitted from TS-Tokamak plasmas

Energy Technology Data Exchange (ETDEWEB)

Platz, P. [Association Euratom-CEA, Centre d`Etudes de Cadarache, 13 - Saint-Paul-lez-Durance (France). Dept. de Recherches sur la Fusion Controlee; Cornille, M.; Dubau, J. [Observatoire de Paris, 92 - Meudon (France)

1996-01-01

X-ray line spectra from highly charged impurity ions have been taken with a high-resolution Bragg-crystal spectrometer on the Tore Supra (TS) tokamak. By cross-checking the wavelengths of reference lines from the heliumlike ions Ti20 + (2.6 Angstroms) and Ar16 + (3.95 Angstroms) we first demonstrate that it is possible to measure wavelengths with a precision, {lambda}/{delta}{lambda}, of better than 50000. We than determine the wavelengths of n=3 to n=2 transitions of neonlike Ag37+ in the 4 Angstroms spectral range. (authors). 16 refs., 7 figs., 3 tabs.

Permeability and seismic velocity and their anisotropy across the Alpine Fault, New Zealand: An insight from laboratory measurements on core from the Deep Fault Drilling Project phase 1 (DFDP-1)

Science.gov (United States)

Allen, M. J.; Tatham, D.; Faulkner, D. R.; Mariani, E.; Boulton, C.

2017-08-01

The Alpine Fault, a transpressional plate boundary between the Australian and Pacific plates, is known to rupture quasiperiodically with large magnitude earthquakes (Mw 8). The hydraulic and elastic properties of fault zones are thought to vary over the seismic cycle, influencing the nature and style of earthquake rupture and associated processes. We present a suite of laboratory permeability and P (Vp) and S (Vs) wave velocity measurements performed on fault lithologies recovered during the first phase of the Deep Fault Drilling Project (DFDP-1), which sampled principal slip zone (PSZ) gouges, cataclasites, and fractured ultramylonites, with all recovered lithologies overprinted by abundant secondary mineralization, recording enhanced fluid-rock interaction. Core material was tested in three orthogonal directions, orientated relative to the down-core axis and, when present, foliation. Measurements were conducted with pore pressure (H2O) held at 5 MPa over an effective pressure (Peff) range of 5-105 MPa. Permeabilities and seismic velocities decrease with proximity to the PSZ with permeabilities ranging from 10-17 to 10-21 m2 and Vp and Vs ranging from 4400 to 5900 m/s in the ultramylonites/cataclasites and 3900 to 4200 m/s at the PSZ. In comparison with intact country rock protoliths, the highly variable cataclastic structures and secondary phyllosilicates and carbonates have resulted in an overall reduction in permeability and seismic wave velocity, as well as a reduction in anisotropy within the fault core. These results concur with other similar studies on other mature, tectonic faults in their interseismic period.

BiGGEsTS: integrated environment for biclustering analysis of time series gene expression data

Directory of Open Access Journals (Sweden)

Madeira Sara C

2009-07-01

Full Text Available Abstract Background The ability to monitor changes in expression patterns over time, and to observe the emergence of coherent temporal responses using expression time series, is critical to advance our understanding of complex biological processes. Biclustering has been recognized as an effective method for discovering local temporal expression patterns and unraveling potential regulatory mechanisms. The general biclustering problem is NP-hard. In the case of time series this problem is tractable, and efficient algorithms can be used. However, there is still a need for specialized applications able to take advantage of the temporal properties inherent to expression time series, both from a computational and a biological perspective. Findings BiGGEsTS makes available state-of-the-art biclustering algorithms for analyzing expression time series. Gene Ontology (GO annotations are used to assess the biological relevance of the biclusters. Methods for preprocessing expression time series and post-processing results are also included. The analysis is additionally supported by a visualization module capable of displaying informative representations of the data, including heatmaps, dendrograms, expression charts and graphs of enriched GO terms. Conclusion BiGGEsTS is a free open source graphical software tool for revealing local coexpression of genes in specific intervals of time, while integrating meaningful information on gene annotations. It is freely available at: http://kdbio.inesc-id.pt/software/biggests. We present a case study on the discovery of transcriptional regulatory modules in the response of Saccharomyces cerevisiae to heat stress.

Technical principles underlying limit values for release of substances for the percolation test TS3: comparison DE and NL

Energy Technology Data Exchange (ETDEWEB)

Van Zomeren, A.; Dijkstra, J.J. [ECN Environment and Energy Engineering, Petten (Netherlands); Susset, B. [Consulting Office SiWaP (Germany)

2013-10-15

Within CEN TC 351 WG 1, standardized, horizontal test methods are developed to assess the release (leaching) of dangerous substances from construction as defined in ER3 of the CPD. For granular materials TS 3, a horizontal up-flow percolation test, was further developed by CEN TC 351 WG1 and will enter the validation phase in 2013. In CEN TC 351 WG1, there are still discussions regarding the sample preparation and some test conditions. Currently, two options for sample preparation and test conditions are specified. Controversy between DE and NL regarding sample preparation and test conditions and the need for two separate options in the TS 3 percolation test are possibly for a part caused by different approaches for risk assessment in the Netherlands and in Germany and the resulting regulatory concepts. One important reason for this is, that in soil and groundwater regulations the test method and the impact assessment method are systematically linked together but the impact assessment methods and lab methods in both countries are different. The discussions in CEN TC 351 WG 1 show that there is a need to have a better mutual understanding of the relation between test method and impact assessment on the one hand and a clear overview of differences in impact assessment approaches of each country on the other hand. The aim of this project is to explain and compare the assumptions, boundary conditions and conventions of the impact assessment approach that are implemented in the upcoming German Recycling Degree and in the Soil Quality Degree of the Netherlands. Ultimately, a better understanding of the impact assessment approaches provides a basis for further discussion in WG1 to agree on only one option for the percolation test conditions. The following report is prepared by the contractors of Germany and Netherlands together to compare the two country-specific concepts. This report summarizes and explains the presentation given on the 25th of April at TC 351 WG1 in

A route to hydroxylfluorenes: TsOH-mediated condensation reactions of 1,3-diketones with propargylic alcohols

KAUST Repository

Yao, Liangfeng

2012-01-01

An efficient method of preparing hydroxylfluorenes by TsOH-mediated tandem alkylation/rearrangements of propargylic alcohols with 1,3-diketones is described. These reactions are accomplished in moderate to good yields under mild conditions to offer a straightforward and convenient one step synthetic route to hydroxylfluorene derivatives through a plausible mechanism involving a sequence of dehydration, addition, rearrangement and aromatization. This journal is © The Royal Society of Chemistry 2012.

Disruption of Inhibitory Function in the Ts65Dn Mouse Hippocampus Through Overexpression of GIRK2

Science.gov (United States)

2007-10-24

embryological and developmental or a result of later problems. Delays in prenatal growth of the Ts65Dn cerebral cortex and hippocampus due to longer...cultured from both DS patients and model animals are also reportedly more vulnerable to apoptosis (Sawa, 1999). A majority of research investigating cell...death in DS has been limited to several apoptosis -related genes, including those related to oxidative stress, and transcription factors overexpressed

Influence of iron and beryllium additions on heat resistance of silicide coatings on TsMB-30 molybdenum alloy

International Nuclear Information System (INIS)

Zajtseva, A.L.; Fedorchuk, N.M.; Lazarev, Eh.M.; Korotkov, N.A.

1985-01-01

Alloying of titanium modified silicide coatings on TsMB-30 molybdenum alloy with iron or beryllium is stated to improve their protective properties. Coatings with low content of alloying elements have the best protective properties. Service life of coatings is determined by the formed oxide film and phase transformations taking place in the coating

Fatigue behavior of partially stabilized zirconia ceramics

International Nuclear Information System (INIS)

Ferber, M.K.; Hine, T.

1986-01-01

The time-dependent strength variations of two grades of MgO stabilized materials (Mg-PSZ) were measured as a function of temperature and applied stress level. The strength was determined using an interrupted fatigue (I.F.) test in which flexure samples were exposed at temperatures between 500 and 100 0 C for times up to 1008 h. During testing, the applied stress was maintained at a percentage of the short-term strength value measured at the same T. The resulting I.F. data gave evidence of both strengthening and weakening processes. The dominant mechanism at a given temperature was primarily dictated by the stress level. In the present investigation, the fatigue behavior for two grades of Mg-PSZ was evaluated by measuring the time-dependent strength variations as a function of temperature and applied stress level. Changes in microstructure resulting from the high-temperature exposure were determined from subsequent ceramographic, SEM and TEM studies. In addition, x-ray diffraction and dilatometry measurements were used to examine time-dependent variations in the phase assemblage

Test for radioactive material transport package safety

International Nuclear Information System (INIS)

Li Guoqiang; Zhao Bing; Zhang Jiangang; Wang Xuexin; Ma Anping

2012-01-01

Regulations on radioactive material transport in China were introduced. Test facilities and data acquiring instruments for radioactive material package in China Institute for Radiation Protection were also introduced in this paper, which were used in drop test and thermal test. Test facilities were constructed according to the requirements of IAEA's 'Regulations for the Safe Transport of Radioactive Material' (TS-R-l) and Chinese 'Regulations for the Safe Transport of Radioactive Material' (GB 11806-2004). Drop test facilities were used in free drop test, penetration test, mechanical test (free drop test Ⅰ, free drop test Ⅱ and free drop test Ⅲ) of type A and type B packages weighing less than thirteen tons. Thermal test of type B packages can be carried out in the thermal test facilities. Certification tests of type FCo70-YQ package, type 30A-HB-01 package, type SY-I package and type XAYT-I package according to regulations were done using these facilities. (authors)

Gene Electrotransfer of Plasmid with Tissue Specific Promoter Encoding shRNA against Endoglin Exerts Antitumor Efficacy against Murine TS/A Tumors by Vascular Targeted Effects.

Directory of Open Access Journals (Sweden)

Monika Stimac

Full Text Available Vascular targeted therapies, targeting specific endothelial cell markers, are promising approaches for the treatment of cancer. One of the targets is endoglin, transforming growth factor-β (TGF-β co-receptor, which mediates proliferation, differentiation and migration of endothelial cells forming neovasculature. However, its specific, safe and long-lasting targeting remains the challenge. Therefore, in our study we evaluated the transfection efficacy, vascular targeted effects and therapeutic potential of the plasmid silencing endoglin with the tissue specific promoter, specific for endothelial cells marker endothelin-1 (ET (TS plasmid, in comparison to the plasmid with constitutive promoter (CON plasmid, in vitro and in vivo. Tissue specificity of TS plasmid was demonstrated in vitro on several cell lines, and its antiangiogenic efficacy was demonstrated by reducing tube formation of 2H11 endothelial cells. In vivo, on a murine mammary TS/A tumor model, we demonstrated good antitumor effect of gene electrotransfer (GET of either of both plasmids in treatment of smaller tumors still in avascular phase of growth, as well as on bigger tumors, already well vascularized. In support to the observations on predominantly vascular targeted effects of endoglin, histological analysis has demonstrated an increase in necrosis and a decrease in the number of blood vessels in therapeutic groups. A significant antitumor effect was observed in tumors in avascular and vascular phase of growth, possibly due to both, the antiangiogenic and the vascular disrupting effect. Furthermore, the study indicates on the potential use of TS plasmid in cancer gene therapy since the same efficacy as of CON plasmid was determined.

Gene Electrotransfer of Plasmid with Tissue Specific Promoter Encoding shRNA against Endoglin Exerts Antitumor Efficacy against Murine TS/A Tumors by Vascular Targeted Effects.

Science.gov (United States)

Stimac, Monika; Dolinsek, Tanja; Lampreht, Ursa; Cemazar, Maja; Sersa, Gregor

2015-01-01

Vascular targeted therapies, targeting specific endothelial cell markers, are promising approaches for the treatment of cancer. One of the targets is endoglin, transforming growth factor-β (TGF-β) co-receptor, which mediates proliferation, differentiation and migration of endothelial cells forming neovasculature. However, its specific, safe and long-lasting targeting remains the challenge. Therefore, in our study we evaluated the transfection efficacy, vascular targeted effects and therapeutic potential of the plasmid silencing endoglin with the tissue specific promoter, specific for endothelial cells marker endothelin-1 (ET) (TS plasmid), in comparison to the plasmid with constitutive promoter (CON plasmid), in vitro and in vivo. Tissue specificity of TS plasmid was demonstrated in vitro on several cell lines, and its antiangiogenic efficacy was demonstrated by reducing tube formation of 2H11 endothelial cells. In vivo, on a murine mammary TS/A tumor model, we demonstrated good antitumor effect of gene electrotransfer (GET) of either of both plasmids in treatment of smaller tumors still in avascular phase of growth, as well as on bigger tumors, already well vascularized. In support to the observations on predominantly vascular targeted effects of endoglin, histological analysis has demonstrated an increase in necrosis and a decrease in the number of blood vessels in therapeutic groups. A significant antitumor effect was observed in tumors in avascular and vascular phase of growth, possibly due to both, the antiangiogenic and the vascular disrupting effect. Furthermore, the study indicates on the potential use of TS plasmid in cancer gene therapy since the same efficacy as of CON plasmid was determined.

Antigenicity analysis of Vibrio harveyi TS-628 strain

Institute of Scientific and Technical Information of China (English)

QIN Yingxue; WANG Jun; WANG Shifeng; YAN Qingpi

2007-01-01

Vibrio harveyi,the major causative agent of vibriosis,affects a diverse range of marine cultured organisms over a wide geographical area.However,reports about screening the effective antigen and research on vaccines of V.harveyi are scarce.Flagellin,lipopolysaccharide (LPS) and outer membrane proteins (OMP) are major immunogenic antigens in many Gram-negative bacteria.In this study,the flagellin,OMP and LPS of the V.harveyi TS-628 strain isolated from infected groupers were extracted and Western blot analysis was used to detect the antigenicity of these extractions.Results of the Western blot assay reveal that there are four positive flagellin bands:35 kDa,38 kDa,43 kDa,and 52 kDa,of which the 43 kDa and 52 kDa bands displayed the strongest positive reaction.There are five positive OMP bands about 35 kDa,38 kDa,43 kDa,47 kDa,and 52 kDa,of which the 43 kDa appeared to have the strongest positive reaction although the other four proteins also displayed strong reactions.However,LPS is Western blot-negative.These results indicate that the 43 kDa and 52 kDa flagellin and OMP of size 43 kDa,52 kDa can be candidates for developing vaccines against V.harveyi.

Teacher Salary Comparisons--Inter-City Differences: 2010-11 and 2011-12. BCTF Research Report. Section I. 2012-TS-02

Science.gov (United States)

White, Margaret

2012-01-01

This research report, which is an update of research report 2011-TS-03, shows the salary difference for each step of British Columbia's (BC) Category 5 or comparable qualifications. Salaries for Vancouver public school teachers are compared to teacher salaries in Toronto (elementary), Ottawa (secondary), and Edmonton. Salaries for Prince George…

An expert protocol for immunofluorescent detection of calcium channels in tsA-201 cells.

Science.gov (United States)

Koch, Peter; Herzig, Stefan; Matthes, Jan

Pore-forming subunits of voltage gated calcium channels (VGCC) are large membrane proteins (260kDa) containing 24 transmembrane domains. Despite transfection with viral promoter driven vectors, biochemical analysis of VGCC is often hampered by rather low expression levels in heterologous systems rendering VGCC challenging targets. Especially in immunofluorescent detection, calcium channels are demanding proteins. We provide an expert step-by-step protocol with adapted conditions for handling procedures (tsA-201 cell culture, transient transfection, incubation time and temperature at 28°C or 37°C and immunostaining) to address the L-type calcium-channel pore Ca v 1.2 in an immunofluorescent approach. We performed immunocytochemical analysis of Ca v 1.2 expression at single-cell level in combination with detection of different markers for cellular organelles. We show confluency levels and shapes of tsA-201 cells at different time points during an experiment. Our experiments reveal sufficient levels of Ca v 1.2 protein and a correct Ca v 1.2 expression pattern in polygonal shaped cells already 12h after transfection. A sequence of elaborated protocol modifications allows subcellular localization analysis of Ca v 1.2 in an immunocytochemical approach. We provide a protocol that may be used to achieve insights into physiological and pathophysiological processes involving voltage gated calcium channels. Our protocol may be used for expression analysis of other challenging proteins and efficient overexpression may be exploited in related biochemical techniques requiring immunolabels. Copyright © 2016 Elsevier Inc. All rights reserved.

TS Fuzzy Model-Based Controller Design for a Class of Nonlinear Systems Including Nonsmooth Functions

DEFF Research Database (Denmark)

Vafamand, Navid; Asemani, Mohammad Hassan; Khayatiyan, Alireza

2018-01-01

This paper proposes a novel robust controller design for a class of nonlinear systems including hard nonlinearity functions. The proposed approach is based on Takagi-Sugeno (TS) fuzzy modeling, nonquadratic Lyapunov function, and nonparallel distributed compensation scheme. In this paper, a novel...... criterion, new robust controller design conditions in terms of linear matrix inequalities are derived. Three practical case studies, electric power steering system, a helicopter model and servo-mechanical system, are presented to demonstrate the importance of such class of nonlinear systems comprising...

First unitarity-independent determination of the CKM matrix elements $V_{td}$, $V_{ts}$, and ${V_{tb}$ and the implications for unitarity

OpenAIRE

Swain, John; Taylor, Lucas

1997-01-01

The magnitudes of the CKM matrix elements $V_{td}$, $V_{ts}$, and $V_{tb}$ are determined for the first time without any assumptions of unitarity. The implications for the unitarity of the CKM matrix as a whole are discussed.

On stress/strain shielding and the material stiffness paradigm for dental implants.

Science.gov (United States)

Korabi, Raoof; Shemtov-Yona, Keren; Rittel, Daniel

2017-10-01

Stress shielding considerations suggest that the dental implant material's compliance should be matched to that of the host bone. However, this belief has not been confirmed from a general perspective, either clinically or numerically. To characterize the influence of the implant stiffness on its functionality using the failure envelope concept that examines all possible combinations of mechanical load and application angle for selected stress, strain and displacement-based bone failure criteria. Those criteria represent bone yielding, remodeling, and implant primary stability, respectively MATERIALS AND METHODS: We performed numerical simulations to generate failure envelopes for all possible loading configurations of dental implants, with stiffness ranging from very low (polymer) to extremely high, through that of bone, titanium, and ceramics. Irrespective of the failure criterion, stiffer implants allow for improved implant functionality. The latter reduces with increasing compliance, while the trabecular bone experiences higher strains, albeit of an overall small level. Micromotions remain quite small irrespective of the implant's stiffness. The current paradigm favoring reduced implant material's stiffness out of concern for stress or strain shielding, or even excessive micromotions, is not supported by the present calculations, that point exactly to the opposite. © 2017 Wiley Periodicals, Inc.

WIAMan Technology Demonstrator Sensor Codes Conforming to International Organization for Standardization/Technical Standard (ISO/TS) 13499

Science.gov (United States)

2016-03-01

of this collection of information, including suggestions for reducing  the burden, to Department of Defense, Washington Headquarters  Services ...ISO)- Multimedia Exchange task force is responsible for maintaining the specification for the multimedia data exchange format for impact tests outlined...channel codes, ATD, multimedia exchange format, ISO/TS 13499 36 Michael B Tegtmeyer 410-278-6074Unclassified Unclassified Unclassified UU ii

Thermal Power Of The TS-300B Refrigerator in the Aspects of Statistical Research / Moc Cieplna Chłodziarki TS-300B W Aspekcie Badań Statystycznych

Science.gov (United States)

Nowak, Bernard; Łuczak, Rafał

2015-09-01

The article discusses the improvement of thermal working conditions in underground mine workings, using local refrigeration systems. It considers the efficiency of air cooling with direct action air compression refrigerator of the TS-300B type. As a result of a failure to meet the required operating conditions of the aforementioned air cooling system, frequently there are discrepancies between the predicted (and thus the expected) effects of its work and the reality. Therefore, to improve the operating efficiency of this system, in terms of effective use of the evaporator cooling capacity, quality criteria were developed, which are easy in practical application. They were obtained in the form of statistical models, describing the effect of independent variables, i.e. the parameters of the inlet air to the evaporator (temperature, humidity and volumetric flow rate), as well as the parameters of the water cooling the condenser (temperature and volumetric flow rate), on the thermal power of air cooler, treated as the dependent variable. Statistical equations describing the performance of the analyzed air cooling system were determined, based on the linear and nonlinear multiple regression. The obtained functions were modified by changing the values of the coefficients in the case of linear regression, and of the coefficients and exponents in the case of non-linear regression, with the independent variables. As a result, functions were obtained, which were more convenient in practical applications. Using classical statistics methods, the quality of fitting the regression function to the experimental data was evaluated. Also, the values of the evaporator thermal power of the refrigerator, which were obtained on the basis of the measured air parameters, were compared with the calculated ones, by using the obtained regression functions. These statistical models were built on the basis of the results of measurements in different operating conditions of the TS-300B

Functional Dissociation of Confident and Not-Confident Errors in the Spatial Delayed Response Task Demonstrates Impairments in Working Memory Encoding and Maintenance in Schizophrenia

Directory of Open Access Journals (Sweden)

Jutta S. Mayer

2018-05-01

Full Text Available Even though extensively investigated, the nature of working memory (WM deficits in patients with schizophrenia (PSZ is not yet fully understood. In particular, the contribution of different WM sub-processes to the severe WM deficit observed in PSZ is a matter of debate. So far, most research has focused on impaired WM maintenance. By analyzing different types of errors in a spatial delayed response task (DRT, we have recently demonstrated that incorrect yet confident responses (which we labeled as false memory errors rather than incorrect/not-confident responses reflect failures of WM encoding, which was also impaired in PSZ. In the present study, we provide further evidence for a functional dissociation between confident and not-confident errors by manipulating the demands on WM maintenance, i.e., the length over which information has to be maintained in WM. Furthermore, we investigate whether these functionally distinguishable WM processes are impaired in PSZ. Twenty-four PSZ and 24 demographically matched healthy controls (HC performed a spatial DRT in which the length of the delay period was varied between 1, 2, 4, and 6 s. In each trial, participants also rated their level of response confidence. Across both groups, longer delays led to increased rates of incorrect/not-confident responses, while incorrect/confident responses were not affected by delay length. This functional dissociation provides additional support for our proposal that false memory errors (i.e., confident errors reflect problems at the level of WM encoding, while not-confident errors reflect failures of WM maintenance. Schizophrenic patients showed increased numbers of both confident and not-confident errors, suggesting that both sub-processes of WM—encoding and maintenance—are impaired in schizophrenia. Combined with the delay length-dependent functional dissociation, we propose that these impairments in schizophrenic patients are functionally distinguishable.

Els aplecs «ts» i «dz» en valencià. Una anàlisi des de la teoria de l'optimitat

Directory of Open Access Journals (Sweden)

Jesús Jiménez

2015-10-01

Full Text Available This article intends to demonstrate that the final form of the clusters /ts/ and /dz/ in the Valencian dialect depends upon the behaviour of a series of universal principles referring to the syllabic structure. The author assumes that such restrictions are ranked on a language particular basis, according to the postulates of Optimality Theory (Prince & Smolensky 1993. Then, the outputs for the alveolar clusters will be the result of applying the constraint hierarchy to the set of possible candidates consistent with every input. The different results of the clusters /ts/ and /dz/ in Valencian, and this dialect' s divergences from other Catalan varieties are explained by the differences in the ranking of the principles which each variety presents.

Alterations to dendritic spine morphology, but not dendrite patterning, of cortical projection neurons in Tc1 and Ts1Rhr mouse models of Down syndrome.

Directory of Open Access Journals (Sweden)

Matilda A Haas

Full Text Available Down Syndrome (DS is a highly prevalent developmental disorder, affecting 1/700 births. Intellectual disability, which affects learning and memory, is present in all cases and is reflected by below average IQ. We sought to determine whether defective morphology and connectivity in neurons of the cerebral cortex may underlie the cognitive deficits that have been described in two mouse models of DS, the Tc1 and Ts1Rhr mouse lines. We utilised in utero electroporation to label a cohort of future upper layer projection neurons in the cerebral cortex of developing mouse embryos with GFP, and then examined neuronal positioning and morphology in early adulthood, which revealed no alterations in cortical layer position or morphology in either Tc1 or Ts1Rhr mouse cortex. The number of dendrites, as well as dendrite length and branching was normal in both DS models, compared with wildtype controls. The sites of projection neuron synaptic inputs, dendritic spines, were analysed in Tc1 and Ts1Rhr cortex at three weeks and three months after birth, and significant changes in spine morphology were observed in both mouse lines. Ts1Rhr mice had significantly fewer thin spines at three weeks of age. At three months of age Tc1 mice had significantly fewer mushroom spines--the morphology associated with established synaptic inputs and learning and memory. The decrease in mushroom spines was accompanied by a significant increase in the number of stubby spines. This data suggests that dendritic spine abnormalities may be a more important contributor to cognitive deficits in DS models, rather than overall neuronal architecture defects.

Physiochemical and antioxidant properties of roselle-mango juice blends; effects of packaging material, storage temperature and time

Science.gov (United States)

Mgaya-Kilima, Beatrice; Remberg, Siv Fagertun; Chove, Bernard Elias; Wicklund, Trude

2015-01-01

A study was conducted to determine the effects of packaging materials, seasonality, storage temperature and time on physiochemical and antioxidant properties of roselle-mango juice blends. Roselle extract (20%, 40%, 60%, and 80%) was mixed with mango juice and stored in glass and plastic bottles at 4°C and 28°C. Total soluble solids, pH, titratable acidity, reducing sugar, color, vitamin C, total monomeric anthocyanins, total phenols, and antioxidant activity (FRAP) were evaluated in freshly prepared juice, and after, 2, 4, and 6 months of storage. The results showed that total soluble solids, reducing sugars, and pH increased with storage times under different storage time, irrespective of packaging materials. The acidity, color, total monomeric anthocyanin, vitamin C, total phenols, and antioxidant activity decreased during storage irrespective of storage temperature and packaging material. Loss of anthocyanins, total phenols, and vitamin C content were higher in blends stored at 28°C than 4°C. PMID:25838888

"edo jal̀qkina üts̀varòkaetus ma vaelda ..." : [luuletused] / Andreas Kalkun

Index Scriptorium Estoniae

Kalkun, Andreas, 1977-

2002-01-01

Sisu: "edo jal̀qkina üts̀varòkaetus ma vaelda ..." ; "tsirguq ku kiviq no satassõ taivast aràlaq ..." ; "vahtsõq silmäq pitsitä pääluu sisse ..." ; "tõppõ tõmmat haigõst ma haarõt jal̀ki ..." ; "arsatas njago sisse aigopiteh ..." ; "rühkeq yks jumalat pallõlda jaloh ..." ; "mu süä om no süüdläne täǹtäseq kuvvõ ..." ; "halvaq haavaq häitsese veiga silmih. Eluloolisi andmeid autori kohta lk. 379

Experimental data report for Test TS-1 Reactivity Initiated Accident Test in NSRR with pre-irradiated BWR fuel rod

International Nuclear Information System (INIS)

Nakamura, Takehiko; Yoshinaga, Makio; Sobajima, Makoto; Fujishiro, Toshio; Horiki, Ohichiro; Yamahara, Takeshi; Ichihashi, Yoshinori; Kikuchi, Teruo

1992-01-01

This report presents experimental data for Test TS-1 which was the first in a series of tests, simulating Reactivity Initiated Accident (RIA) conditions using pre-irradiated BWR fuel rods, performed in the Nuclear Safety Research Reactor (NSRR) in October, 1989. Test fuel rod used in the Test TS-1 was a short-sized BWR (7 x 7) type rod which was fabricated from a commercial rod provided from Tsuruga Unit 1 power reactor. The fuel had an initial enrichment of 2.79 % and burnup of 21.3 GWd/t (bundle average). Pulse irradiation was performed at a condition of stagnant water cooling, atmospheric pressure and ambient temperature using a newly developed double container-type capsule. Energy deposition of the rod in this test was evaluated to be about 61 cal/g·fuel (55 cal/g·fuel in peak fuel enthalpy) and no fuel failure was observed. Descriptions on test conditions, test procedures, fuel burnup measurements, transient behavior of the test rod during pulse irradiation and results of post pulse irradiation examinations are contained in this report. (author)

Les méthodes de quantification économique des coûts sanitaires de la pollution atmosphérique : application à l’Ile-de-France

OpenAIRE

Géniaux, Ghislain; Rabl, Ari

2007-01-01

Cet article passe en revue les méthodes de quantification économique des coûts sanitaires de la pollution atmosphérique. Ces méthodes sont appliquées à l’Ile-de-France, à partir de l’étude épidémiologique ERPURS sur les effets aiguës de la pollution sur la santé, et d’autres études internationales. La plus grande partie des coûts est imputable aux effets chroniques des particules sur la mortalité. This pape reviews the methods that can be used for evaluating the costs of health damages due...

Research on Fault Diagnosis for Pumping Station Based on T-S Fuzzy Fault Tree and Bayesian Network

Directory of Open Access Journals (Sweden)

Zhuqing Bi

2017-01-01

Full Text Available According to the characteristics of fault diagnosis for pumping station, such as the complex structure, multiple mappings, and numerous uncertainties, a new approach combining T-S fuzzy gate fault tree and Bayesian network (BN is proposed. On the one hand, traditional fault tree method needs the logical relationship between events and probability value of events and can only represent the events with two states. T-S fuzzy gate fault tree method can solve these disadvantages but still has weaknesses in complex reasoning and only one-way reasoning. On the other hand, the BN is suitable for fault diagnosis of pumping station because of its powerful ability to deal with uncertain information. However, it is difficult to determine the structure and conditional probability tables of the BN. Therefore, the proposed method integrates the advantages of the two methods. Finally, the feasibility of the method is verified through a fault diagnosis model of the rotor in the pumping unit, the accuracy of the method is verified by comparing with the methods based on traditional Bayesian network and BP neural network, respectively, when the historical data is sufficient, and the results are more superior to the above two when the historical data is insufficient.

Hybridized Plasmons in 2D Nanoslits: From Graphene to Anisotropic 2D Materials

DEFF Research Database (Denmark)

Gonçalves, P. A. D.; Xiao, Sanshui; Peres, N. M. R.

2017-01-01

of arbitrary width, and remains valid irrespective of the 2D conductive material (e.g., doped graphene, 2D transition metal dichalcogenides, or phosphorene). We derive the dispersion relation of the hybrid modes of a 2D nanoslit along with the corresponding induced potential and electric field distributions...

Evaluation of Activity Concentration Values and Doses due to the Transport of Low Level Radioactive Material

Energy Technology Data Exchange (ETDEWEB)

Rawl, Richard R [ORNL; Scofield, Patricia A [ORNL; Leggett, Richard Wayne [ORNL; Eckerman, Keith F [ORNL

2010-04-01

The International Atomic Energy Agency (IAEA) initiated an international Coordinated Research Project (CRP) to evaluate the safety of transport of naturally occurring radioactive material (NORM). This report presents the United States contribution to that IAEA research program. The focus of this report is on the analysis of the potential doses resulting from the transport of low level radioactive material. Specific areas of research included: (1) an examination of the technical approach used in the derivation of exempt activity concentration values and a comparison of the doses associated with the transport of materials included or not included in the provisions of Paragraph 107(e) of the IAEA Safety Standards, Regulations for the Safe Transport of Radioactive Material, Safety Requirements No. TS-R-1; (2) determination of the doses resulting from different treatment of progeny for exempt values versus the A{sub 1}/A{sub 2} values; and (3) evaluation of the dose justifications for the provisions applicable to exempt materials and low specific activity materials (LSA-I). It was found that the 'previous or intended use' (PIU) provision in Paragraph 107(e) is not risk informed since doses to the most highly exposed persons (e.g., truck drivers) are comparable regardless of intended use of the transported material. The PIU clause can also have important economic implications for co-mined ores and products that are not intended for the fuel cycle but that have uranium extracted as part of their industrial processing. In examination of the footnotes in Table 2 of TS-R-1, which identifies the progeny included in the exempt or A1/A2 values, there is no explanation of how the progeny were selected. It is recommended that the progeny for both the exemption and A{sub 1}/A{sub 2} values should be similar regardless of application, and that the same physical information should be used in deriving the limits. Based on the evaluation of doses due to the transport of low

Electrical Resistance of Ag-TS-S(CH2)(n-1)CH3//Ga2O3/EGaln Tunneling Junctions

NARCIS (Netherlands)

Cademartiri, Ludovico; Thuo, Martin M.; Nijhuis, Christian A.; Reus, William F.; Tricard, Simon; Barber, Jabulani R.; Sodhi, Rana N. S.; Brodersen, Peter; Kim, Choongik; Chiechi, Ryan C.; Whitesides, George M.

2012-01-01

Tunneling junctions having the structure Ag-TS-S(CH2)(n-1)CH3//Ga2O3/EGaIn allow physical-organic studies of charge transport across self-assembled monolayers (SAMs). In ambient conditions, the surface of the liquid metal electrode (EGaIn, 75.5 wt % Ga, 24.5 wt % In, mp 15.7 degrees C) oxidizes and

Bactericidal activity of culture fluid components of Lactobacillus fermentum strain 90 TS-4 (21) clone 3, and their capacity to modulate adhesion of Candida albicans yeast-like fungi to vaginal epithelial cells.

Science.gov (United States)

Anokhina, I V; Kravtsov, E G; Protsenko, A V; Yashina, N V; Yermolaev, A V; Chesnokova, V L; Dalin, M V

2007-03-01

Antagonistic activities of L. fermentum strain 90 TS-4 (21), L. casei ATCC 27216, and L. acidophilus ATCC 4356 and bactericidal activity of lactobacillus culture fluid towards E. coli strain K12, S. aureus, and S. epidermidis test cultures were studied. The bactericidal effect of L. fermentum strain 90 TS-4 (21) clone 3 culture fluid preparation (pH 6.0) on the test cultures was dose-dependent. Adhesion of C. albicans yeast-like fungi to vaginal epitheliocytes was more pronounced for strains isolated from women with asymptomatic infection than for strains isolated from women with manifest forms. L. fermentum strain 90 TS-4 (21) clone 3 culture fluid preparation modulated adhesion of yeast-like fungi only if the fungal strain was initially highly adherent.

LHC optics determination with proton tracks measured in the CT-PPS detectors in 2016, before TS2

CERN Document Server

Nemes, F

2017-01-01

Novel optics estimation methods have been developed for the CMS-TOTEM Precision Proton Spectrometer (CT-PPS), in order to determine the horizontal dispersion function $D_{x}$ and the orbit between IP5 and the Roman Pot detectors. The tools have been successfully applied at $\\sqrt{s} = $13 TeV collision energy and $\\beta^{*} = $0.4 m optics with $\\alpha = 370\\,\\mu$rad horizontal crossing angle (settings valid in 2016 before Technical Stop 2 - TS2).

High-resolution empirical geomagnetic field model TS07D: Investigating run-on-request and forecasting modes of operation

Science.gov (United States)

Stephens, G. K.; Sitnov, M. I.; Ukhorskiy, A. Y.; Vandegriff, J. D.; Tsyganenko, N. A.

2010-12-01

The dramatic increase of the geomagnetic field data volume available due to many recent missions, including GOES, Polar, Geotail, Cluster, and THEMIS, required at some point the appropriate qualitative transition in the empirical modeling tools. Classical empirical models, such as T96 and T02, used few custom-tailored modules to represent major magnetospheric current systems and simple data binning or loading-unloading inputs for their fitting with data and the subsequent applications. They have been replaced by more systematic expansions of the equatorial and field-aligned current contributions as well as by the advanced data-mining algorithms searching for events with the global activity parameters, such as the Sym-H index, similar to those at the time of interest, as is done in the model TS07D (Tsyganenko and Sitnov, 2007; Sitnov et al., 2008). The necessity to mine and fit data dynamically, with the individual subset of the database being used to reproduce the geomagnetic field pattern at every new moment in time, requires the corresponding transition in the use of the new empirical geomagnetic field models. It becomes more similar to runs-on-request offered by the Community Coordinated Modeling Center for many first principles MHD and kinetic codes. To provide this mode of operation for the TS07D model a new web-based modeling tool has been created and tested at the JHU/APL (http://geomag_field.jhuapl.edu/model/), and we discuss the first results of its performance testing and validation, including in-sample and out-of-sample modeling of a number of CME- and CIR-driven magnetic storms. We also report on the first tests of the forecasting version of the TS07D model, where the magnetospheric part of the macro-parameters involved in the data-binning process (Sym-H index and its trend parameter) are replaced by their solar wind-based analogs obtained using the Burton-McPherron-Russell approach.

The System 80+ Standard Plant design control document. Volume 18

International Nuclear Information System (INIS)

1997-01-01

This Design Control Document (DCD) is a repository of information comprising the System 80+trademark Standard Plant Design. The DCD also provides that design-related information to be incorporated by reference in the design certification rule for the System 80+ Standard Plant Design. Applicants for a combined license pursuant to 10 CFR 52 must ensure that the final Design Certification Rule and the associated Statements of Consideration are used when making all licensing decisions relevant to the System 80+ Standard Plant Design. The Design Control Document contains the DCD introduction, The Certified Design Material (CDM) [i.e., ''Tier 1''] and the Approved Design Material (ADM) [i.e., ''Tier 2''] for the System 80+ Standard Plant Design. The CDM includes the following sections: (1) Introductory material; (2) Certified Design Material for System 80+ systems and structures; (3) Certified Design Material for non-system-based aspects of the System 80+ Certified design; (4) Interface requirements; and (5) Site parameters. The ADM, to the extent applicable for the System 80+ Standard Plant Design, includes: (1) the information required for the final safety analysis report under 20 CFR 50.34; (2) other relevant information required by 10 CFR 52.47; and (3) emergency operations guidelines. This volume contains the following technical specifications of section 16 (Technical Specifications) of the ADM Design and Analysis: TS 3.3 Instrumentation; TS 3.4 Reactor Coolant System; TS 3.5 Emergency Core Cooling System; TS 3.6 Containment Systems; TS 3.7 Plant Systems; TS 3.8 Electrical Power Systems; TS 3.9 Refueling Operations; TS 4.0 Design Features; TS 5.0 Administrative Controls. Appendix 16 A Tech Spec Bases is also included. It contains the following: TS B2.0 Safety Limits Bases; TS B3.0 LCO Applicability Bases; TS B3.1 Reactivity Control Bases; TS B3.2 Power Distribution Bases

Changes in the regulations for the safe transport of radioactive material

International Nuclear Information System (INIS)

Lopez Vietri, Jorge R.; Vidal, Dora N.; Piumetti, Elsa H.; Capadona, Nancy M.

2000-01-01

The objective of this paper is to describe and to analyze the relevant changes, dealing with the design, operation and administrative requirements, to be introduced in the Revision 1 of the AR 10.16.1 standard 'Transport of radioactive material' that will be put into force on July, 1st 2001 by the Nuclear Regulatory Authority (competent authority of Argentina). In that way, the Revision 1 of the mentioned standard will be coincident with the 1996 edition (revised) of the 'Regulations for the safe transport of radioactive material', Safety Standards Series No. TS-R-1 (ST-1, revised) issued by the International Atomic Energy Agency (IAEA). (author)

Dos and Don’ts for butterflies of the Habitats Directive of the European Union

Directory of Open Access Journals (Sweden)

Chris van Swaay

2012-03-01

Full Text Available Twenty-nine butterfly species are listed on the Annexes of the Habitats Directive. To assist everyone who wants or needs to take action for one of these species, we compiled an overview of the habitat requirements and ecology of each species, as well as information on their conservation status in Europe. This was taken from the recent Red List and their main biogeographical regions (taken from the first reporting on Article 17 of the Directive. Most important are the Dos and Don`ts, which summarize in a few bullet points what to do and what to avoid in order to protect and conserve these butterflies and their habitats.

Materials testing for in situ stabilization treatability study of INEEL mixed wastes soils

International Nuclear Information System (INIS)

Heiser, J.; Fuhrmann, M.

1997-09-01

This report describes the contaminant-specific materials testing phase of the In Situ Stabilization Comprehensive Environment Response, Compensation, and Liability Act (CERCLA) Treatability Study (TS). The purpose of materials testing is to measure the effectiveness of grouting agents to stabilize Idaho National Engineering and Environmental Laboratory (INEEL) Acid Pit soils and select a grout material for use in the Cold Test Demonstration and Acid Pit Stabilization Treatability Study within the Subsurface Disposal Area (SDA) at the Radioactive Waste Management Complex (RWMC). Test results will assist the selecting a grout material for the follow-on demonstrations described in Test Plan for the Cold Test Demonstration and Acid Pit Stabilization Phases of the In Situ Stabilization Treatability Study at the Radioactive Waste Management Complex

Synthesis and morphology research of framework Ti-rich TS-1 containing no extraframework Ti species in the presence of CO2

KAUST Repository

Zhu, Guowei; Ni, Lei; Qi, Wei; Ding, Shuang; Li, Xiaoxin; Wang, Runwei; Qiu, Shilun

2014-01-01

A new method to synthesis TS-1 has been developed using the carbon dioxide (CO2) as an alkalinity regulator that resulted in the increased framework Ti contents. The prepared catalyst had a Si/Ti ratio as low as 40 in contrast to the ratio of 56

An improved FEM model for computing transport AC loss in coils made of RABiTS YBCO coated conductors for electric machines

DEFF Research Database (Denmark)

Ainslie, Mark D; Rodriguez Zermeno, Victor Manuel; Hong, Zhiyong

2011-01-01

and magnetic field-dependent critical current densities, and the inclusion and exclusion of a magnetic substrate, as found in RABiTS (rolling-assisted biaxially textured substrate) YBCO coated conductors. The coil model is based on the superconducting stator coils used in the University of Cambridge EPEC...

Application of Electro Chemical Machining for materials used in extreme conditions

Science.gov (United States)

Pandilov, Z.

2018-03-01

Electro-Chemical Machining (ECM) is the generic term for a variety of electrochemical processes. ECM is used to machine work pieces from metal and metal alloys irrespective of their hardness, strength or thermal properties, through the anodic dissolution, in aerospace, automotive, construction, medical equipment, micro-systems and power supply industries. The Electro Chemical Machining is extremely suitable for machining of materials used in extreme conditions. General overview of the Electro-Chemical Machining and its application for different materials used in extreme conditions is presented.

Light-cone reduction vs. TsT transformations: a fluid dynamics perspective

Science.gov (United States)

Dutta, Suvankar; Krishna, Hare

2018-05-01

We compute constitutive relations for a charged (2+1) dimensional Schrödinger fluid up to first order in derivative expansion, using holographic techniques. Starting with a locally boosted, asymptotically AdS, 4 + 1 dimensional charged black brane geometry, we uplift that to ten dimensions and perform TsT transformations to obtain an effective five dimensional local black brane solution with asymptotically Schrödinger isometries. By suitably implementing the holographic techniques, we compute the constitutive relations for the effective fluid living on the boundary of this space-time and extract first order transport coefficients from these relations. Schrödinger fluid can also be obtained by reducing a charged relativistic conformal fluid over light-cone. It turns out that both the approaches result the same system at the end. Fluid obtained by light-cone reduction satisfies a restricted class of thermodynamics. Here, we see that the charged fluid obtained holographically also belongs to the same restricted class.

Ethnicity, development and gender: Tsáchila indigenous women in Ecuador.

Science.gov (United States)

Radcliffe, Sarah; Pequeño, Andrea

2010-01-01

In recent decades, indigenous populations have become the subjects and agents of development in national and international multicultural policy that acknowledges poverty among indigenous peoples and their historic marginalization from power over development. Although the impact of these legal and programmatic efforts is growing, one persistent axis of disadvantage, male–female difference, is rarely taken into account in ethno-development policy and practice. This article argues that assumptions that inform policy related to indigenous women fail to engage with indigenous women's development concerns. The institutional separation between gender and development policy (GAD) and multiculturalism means that provisions for gender in multicultural policies are inadequate, and ethnic rights in GAD policies are invisible. Drawing on post-colonial feminism, the paper examines ethnicity and gender as interlocking systems that structure indigenous women's development experiences. These arguments are illustrated in relation to the case of the Tsáchila ethno-cultural group in the South American country of Ecuador.

Experimental-laboratory studies of a composition based on TS-10 resin designed for insulation operations

Energy Technology Data Exchange (ETDEWEB)

Vyazel' shchikov, V M; Glukhov, A M

1979-01-01

Results are presented from studying the technological parameters of a strengthened argillaceous solution (SAS) conducted using the method of planning partial experiments. Particular empirical relationships are found which provide a concept about the degree of influence of each of the SAS components (TS-10 resins of paraform, water, clay) on the rate of structure-formation and mechanical strength. Summary relationships are obtained: the time for viscosity to reach 500% cP-SAS composition and ultimate compression strength SAS composition which can be used in selecting the formula for the mixture for the insulation operations in an ''cold'' well.

Use of waste materials in rubber matrix

Directory of Open Access Journals (Sweden)

Pajtášová Mariana

2018-01-01

Full Text Available The presented paper deals with the use of waste materials as ecological fillers into rubber matrix. Waste materials were used as partial replacement of the commercial filler – carbon black, designated as N339. These prepared rubber compounds were characterized on the basis of the rheology and vulcanization characteristics – minimum torque (ML, maximum torque (MH, optimum time of vulcanization (t(c90, processing safety of compound (ts, rate coefficient of vulcanization (Rv. In the case of the prepared vulcanizates, physical-mechanical properties (tensile strength, tensibility and hardness and dynamic-mechanical properties (storage modulus, loss modulus, loss angle tan δ were investigated. Using the dependency of loss angle on temperature, the selected properties for tyre tread vulcanizates were evaluated, including traction on snow and ice, traction on the wet surface and rolling resistance.

Experimental data report for Test TS-2 reactivity initiated accident test in NSRR with pre-irradiated BWR fuel rod

International Nuclear Information System (INIS)

Nakamura, Takehiko; Yoshinaga, Makio; Sobajima, Makoto; Fujishiro, Toshio; Kobayashi, Shinsho; Yamahara, Takeshi; Sukegawa, Tomohide; Kikuchi, Teruo

1993-02-01

This report presents experimental data for Test TS-2 which was the second test in a series of Reactivity Initiated Accident (RIA) condition test using pre-irradiated BWR fuel rods, performed at the Nuclear Safety Research Reactor (NSRR) in February, 1990. Test fuel rod used in the Test TS-2 was a short sized BWR (7x7) type rod which was fabricated from a commercial rod irradiated at Tsuruga Unit 1 power reactor. The fuel had an initial enrichment of 2.79% and a burnup of 21.3Gwd/tU (bundle average). A pulse irradiation of the test fuel rod was performed under a cooling condition of stagnant water at atmospheric pressure and at ambient temperature which simulated a BWR's cold start-up RIA event. The energy deposition of the fuel rod in this test was evaluated to be 72±5cal/g·fuel (66±5cal/g·fuel in peak fuel enthalpy) and no fuel failure was observed. Descriptions on test conditions, test procedures, transient behavior of the test rod during the pulse irradiation, and, results of pre and post pulse irradiation examinations are described in this report. (author)

Physical, thermal and mechanical study of MPC formulated with LG-MgO incorporating Phase Change Materials as admixture

Science.gov (United States)

Maldonado-Alameda, A.; Lacasta, A. M.; Giro-Paloma, J.; Chimenos, J. M.; Formosa, J.

2017-10-01

The high environmental impact generated by using of Ordinary Portland Cement (OPC) has lead to the search for alternative materials in the field of civil and building engineering. In addition, there is a tendency to develop cements from industrial by-products, thus reducing pollution and emissions generated by their production. One of the best positioned cements to compete with OPC is Magnesium Phosphate Cement (MPC). The present work studies different dosages of MPC mortars formulated with low-grade MgO by-product (sustainable MPC) incorporating Microencapsulated Phase Change Materials (MPCM) and air entraining additive (AEA) as admixtures (Thermal Sustainable MPC) to improve the thermal behaviour of the material. The aim is developed a new eco-friendly material that leads to reducing energy consumption in buildings. The study is focused on the physical, thermal, and mechanical characterization of TS-MPC mortars to assess their potential use as a thermal prefabricated panel. The results allow to relate the amount of the MPCM and the additive percentage with the thermal and mechanical properties of the TS- MPC. Furthermore, is important to highlight the influence of MPCM not only in the thermal behaviour but also on the increase of the porosity. The experimental results show that the addition of both additives contributes substantially to the improvement of the thermal behaviour of the mortars and converts them on a suitable material to reduce thermal oscillations in buildings.

Performance of the transition radiation detector flown on the NMSU/WIZARD TS93 balloon-borne instrument

Energy Technology Data Exchange (ETDEWEB)

Aversa, F.; Barbiellini, G.; Boezio, M. [Trieste Univ. (Italy). Dip. di Fisica]|[INFN, Trieste (Italy); Basini, G.; Brancaccio, F.M. [INFN, Laboratori nazionali di Frascati, Frascati, Rome (Italy); Bellotti, R. [Bari Univ. (Italy). Dip. di Fisica]|[INFN, Bari (Italy); Bidoli, V. [Rome Univ. `Tor Vergata` (Italy). Dip. di Fisica]|[INFN, Sezione Univ. `Tor Vergata` Rome (Italy); Bocciolini, M. [Florence Univ. (Italy). Dip. di Fisica]|[INFN, Florence (Italy); Bronzini, F. [Rome Univ. `La Sapienza` (Italy). Dip. di Fisica]|[INFN, Sezione Univ. `La Sapienza` Rome (Italy)

1995-09-01

It is built and tested a transition radiation detector (TRD) to discriminate positrons from protons in the balloon flight TS 93 experiment. It is presented the TRD performance using flight data obtaining a proton-positron rejection factor of the order of 10{sup -3}. During the 24 hour flight, the data in the momentum range 4-50 GeV/c are collected. Using the TRD together with the Silicon calorimeter, it is achieved an overall rejection factor of about 10{sup -5} of positron against the proton background over the entire momentum range.

Fracture mechanics of ceramics. Vol. 8. Microstructure, methods, design, and fatigue

International Nuclear Information System (INIS)

Bradt, R.C.; Evans, A.G.; Hasselman, D.P.H.; Lange, F.F.

1986-01-01

This paper presents information on the following topics: fracture mechanics and microstructures; non-lubricated sliding wear of Al 2 O 3 , PSZ and SiC; mixed-mode fracture of ceramics; some fracture properties of alumina-containing electrical porcelains; transformation toughening in the Al 2 O 3 -Cr 2 O 3 /ZrO 2 -HfO 2 system; strength toughness relationships for transformation toughened ceramics; tensile strength and notch sensitivity of Mg-PSZ; fracture mechanisms in lead zirconate titanate ceramics; loading-unloading techniques for determining fracture parameters of brittle materials utilizing four-point bend, chevron-notched specimens; application of the potential drop technique to the fracture mechanics of ceramics; ceramics-to-metal bonding from a fracture mechanics perspective; observed changes in fracture strength following laser irradiation and ion beam mixing of Ni overlayers on sintered alpha-SiC; crack growth in single-crystal silicon; a fracture mechanics and non-destructive evaluation investigation of the subcritical-fracture process in rock; slow crack growth in sintered silicon nitride; uniaxial tensile fatigue testing of sintered silicon carbide under cyclic temperature change; and effect of surface corrosion on glass fracture

Risk based definition of TS requirements for NPPs with WWER-1000 type reactor

International Nuclear Information System (INIS)

Morozov, V.; Tokmachev, G.

2000-01-01

The main regulations in safety related maintenance for NPPs in Russia are defined as a part of Technical Specifications (TSs). It includes limiting conditions for operation (surveillance requirements, allowed outage time, et.). In Russian practice the two levels of TSs are presented: general TSs that have been established as a master documents for similar designed NPPs and plant specific based on operation practice of each NPP unit. This paper presents a brief review of submissions to TS changes for NPPs with WWER type reactor were issued by AEP PSA team since 1988 year. Besides it provides an approach allows to estimate the complex affect on plant risk for both Limiting Conditions of Operation (LCO) and Surveillance Test Intervals (STI) based on relevant probabilistic tool (Minimal Cut Sets method and Marcov Chains methods). (author)

PRODUCT NEEM AZAL T/S - BROAD-SPECTRUM PHYPOPESTICIDE FOR CONTROL OF PESTS ON VEGETABLE CROPS

Directory of Open Access Journals (Sweden)

Vinelina Yankova

2016-09-01

Full Text Available Experiments for determination of the effectiveness of product Neem Azal T/S (a. i. azadirachtin were conducted at a concentration of 0,3% against some major pests in vegetable crops grown in greenhouses at the Maritsa Vegetable Crops research Institute, Plovdiv during the period 2010-2016. It was established very good insecticidal and acaricidal action of phytopesticide against: cotton aphid (Aphis gossypii Glov.; green peach aphid (Myzus persicae Sulz.; western flower trips (Frankliniella occidentalis Perg.; cotton bollworm (Helicoverpa armigera Hubn.; tomato borer (Tuta absoluta Meyrick and two-spotted spider mite (Tetranichus urticae Koch.. This product is a successful alternative to using chemical insecticides and acaricides.

Development and validation of the functional assessment of chronic illness therapy treatment satisfaction (FACIT TS) measures.

Science.gov (United States)

Peipert, John D; Beaumont, Jennifer L; Bode, Rita; Cella, Dave; Garcia, Sofia F; Hahn, Elizabeth A

2014-04-01

To develop and validate a new functional assessment of chronic illness therapy (FACIT) measure of satisfaction with treatment for chronic illnesses such as cancer and HIV/AIDS. To define domains and generate items, a literature review informed creation of semi-structured interview guides for patients and an international expert panel of clinicians and researchers. Patients and experts also rated 15 areas of satisfaction for relevance. The final list of items underwent further refinement by the original expert panel and a new group of clinical experts. Items were tested in four studies (primarily lung cancer) and data were pooled for analysis. Exploratory and confirmatory factor analyses (CFA), and item response theory modeling were conducted to evaluate dimensionality. Internal consistency reliability and test-retest reliability were both evaluated. Validity was evaluated by correlating the FACIT subscale scores and measures of comparable concepts and by testing the scales' ability to distinguish people according to their overall treatment satisfaction. Two instruments were created: the FACIT TS-general (G), an overall evaluation of current treatment, and the FACIT TS-patient satisfaction (PS), a measure of patient satisfaction. CFA results were not optimal for a five-factor solution for PS. Internal consistency reliability met psychometric standards (≥0.70) for all PS subscales. Construct validity was established for the PS subscales: Physician Communication, Treatment Staff Communication, Technical Competence, Confidence and Trust, and Nurse Communication. The two instruments generated here offer a new way to assess several key dimensions of patient satisfaction with treatment, especially for people with lung cancer.

Use of neural network techniques to identify cosmic ray electrons and positrons during the 1993 balloon flight of the NMSU/Wizard-TS93 instrument

Energy Technology Data Exchange (ETDEWEB)

Bellotti, R.; Castellano, M. [Bari Univ. (Italy)]|[INFN, Bari (Italy); Candusso, M.; Casolino, M.; Morselli, A.; Picozza, P. [Rome Univ. `Tor Vergata` (Italy)]|[INFN, Rome (Italy); Aversa, F.; Boezio, M. [Trieste Univ. (Italy)]|[INFN, Trieste (Italy); Barbiellini, G. [Trieste Univ. (Italy)]|[INFN, Trieste (Italy); Basini, G. [INFN, Laboratori Nazionali di Frascati, Rome (Italy)

1995-09-01

The detectors used in the TS93 balloon flight produced a large volume of information for each cosmic ray trigger. Some of the data was visual in nature, other portions contained energy deposition and timing information. The data sets are amenable to conventional analysis techniques but there is no assurance that conventional techniques make full use of subtle correlations and relations amongst the detector responses. With the advent of neural network technologies, particularly adept at classification of complex phenomena, it would seem appropriate to explore the utility of neural network techniques to classify particles observed with the instruments. In this paper neural network based methodology for signal/background discrimination in a cosmic ray space experiment is discussed. Results are presented for electron and positron classification in the TS93 flight data set and will be compared to conventional analyses.

Ipragliflozin Improves Hepatic Steatosis in Obese Mice and Liver Dysfunction in Type 2 Diabetic Patients Irrespective of Body Weight Reduction.

Directory of Open Access Journals (Sweden)

Chikara Komiya

Full Text Available Type 2 diabetes mellitus (T2DM is associated with a high incidence of non-alcoholic fatty liver disease (NAFLD related to obesity and insulin resistance. Currently, medical interventions for NAFLD have focused on diet control and exercise to reduce body weight, and there is a requirement for effective pharmacological therapies. Sodium-glucose cotransporter 2 (SGLT2 inhibitors are oral antidiabetic drugs that promote the urinary excretion of glucose by blocking its reabsorption in renal proximal tubules. SGLT2 inhibitors lower blood glucose independent of insulin action and are expected to reduce body weight because of urinary calorie loss. Here we show that an SGLT2 inhibitor ipragliflozin improves hepatic steatosis in high-fat diet-induced and leptin-deficient (ob/ob obese mice irrespective of body weight reduction. In the obese mice, ipragliflozin-induced hyperphagia occurred to increase energy intake, attenuating body weight reduction with increased epididymal fat mass. There is an inverse correlation between weights of liver and epididymal fat in ipragliflozin-treated obese mice, suggesting that ipragliflozin treatment promotes normotopic fat accumulation in the epididymal fat and prevents ectopic fat accumulation in the liver. Despite increased adiposity, ipragliflozin ameliorates obesity-associated inflammation and insulin resistance in epididymal fat. Clinically, ipragliflozin improves liver dysfunction in patients with T2DM irrespective of body weight reduction. These findings provide new insight into the effects of SGLT2 inhibitors on energy homeostasis and fat accumulation and indicate their potential therapeutic efficacy in T2DM-associated hepatic steatosis.

Les dégâts de la grêle sur les cultures: l'averse du 1er juin 1993 dans le Saumurois

Directory of Open Access Journals (Sweden)

Freddy VINET

1994-12-01

Full Text Available La cartographie fine des dégâts de la grêle sur le vignoble du Saumurois permet d’obtenir des informations intéressantes sur le déroulement des averses de grêle: phase de concentration, coeur de grêle, dissipation.

New Generation of LTCC Materials

Directory of Open Access Journals (Sweden)

Valant, Matjaz

2004-06-01

Full Text Available To reduce the complexity of LTCC systems and so accelerate the development of LTCC tapes with new functionalities it is necessary to reduce the number of phases within a particular tape. This can best be done by using glass-free single-phase ceramic systems. Such a material system consisting of low- and high-permittivity LTCC materials was developed based on Bi eulytite (permittivity; k’=16 and sillenite (k’=40 compounds and the δ-Bi2O3 solid solution with Nb2O5 (k’=90. The Ge and Si analogues of the sillenites and eulytites, and the 0.75Bi2O3⋅0.25Nb2O5 solid solution meet the main requirements for LTCC with respect to their sintering behavior (Ts=850-900oC, their mutual chemical compatibility, their compatibility with a silver electrode as well as their dielectric properties.

Para reducer la complejidad de los sistemas LTCC y así acelerar el desarrollo de láminas de LTCC con nuevas funcionalidades es necesario reducir el número de fases dentro de una determinada lámina. La mejor manera de hacer esto es usar sistemas cerámicos monofásicos libres de fase vítrea. Dicho sistema que consiste en materiales LTCC de baja- y alta-permitividad se ha desarrollado en base a compuestos de Bieulitita (permitividad; k’=16 y silenita (k’=40 y la solución sólida de δ-Bi2O3 con Nb2O5 (k’=90. Los análogos de Ge y Si de las silenitas y eulititas, y la solución sólida 0.75Bi2O3⋅0.25Nb2O5 cumplen los principales requerimientos de los LTCC respecto a su comportamiento de sinterización (Ts=850-900oC, su compatibilidad química mutua y su compatibilidad con electrodos de plata, así como en lo concerniente a sus propiedades dieléctricas.

An attempt to apply the inelastic thermal spike model to surface modifications of CaF2 induced by highly charged ions: comparison to swift heavy ions effects and extension to some others material.

Science.gov (United States)

Dufour, C; Khomrenkov, V; Wang, Y Y; Wang, Z G; Aumayr, F; Toulemonde, M

2017-03-08

Surface damage appears on materials irradiated by highly charged ions (HCI). Since a direct link has been found between surface damage created by HCI with the one created by swift heavy ions (SHI), the inelastic thermal spike model (i-TS model) developed to explain track creation resulting from the electron excitation induced by SHI can also be applied to describe the response of materials under HCI which transfers its potential energy to electrons of the target. An experimental description of the appearance of the hillock-like nanoscale protrusions induced by SHI at the surface of CaF 2 is presented in comparison with track formation in bulk which shows that the only parameter on which we can be confident is the electronic energy loss threshold. Track size and electronic energy loss threshold resulting from SHI irradiation of CaF 2 is described by the i-TS model in a 2D geometry. Based on this description the i-TS model is extended to three dimensions to describe the potential threshold of appearance of protrusions by HCI in CaF 2 and to other crystalline materials (LiF, crystalline SiO 2 , mica, LiNbO 3 , SrTiO 3 , ZnO, TiO 2 , HOPG). The strength of the electron-phonon coupling and the depth in which the potential energy is deposited near the surface combined with the energy necessary to melt the material defines the classification of the material sensitivity. As done for SHI, the band gap of the material may play an important role in the determination of the depth in which the potential energy is deposited. Moreover larger is the initial potential energy and larger is the depth in which it is deposited.

Drop Weight Device Fabrication and Tests for a Dynamic Material Property of Shock-Absorbing Material and Structure in Transportation Package

International Nuclear Information System (INIS)

Choi, Woo Seok; Jeon, Jea Eon; Han, Sang Hyeok; Lee, Sang Hoon; Seo, Ki Seok

2009-01-01

A radioactive material transportation package consists of canister and impact limiters. IAEA Safety Standard Series No. TS-R-1 recommends a drop test to evaluate the structural integrity of a transportation package under a hypothetical accident condition. The free drop test of a transportation package from 9 m height simulates one of accident conditions. The transportation package has a potential energy corresponding to 9 m drop height, and this energy changes to a kinetic energy when it impacts on the target. The energy is absorbed by a deformation of shock-absorbing material so that the minimum energy is transferred to canister. Accordingly, the shock-absorbing material is a very important part in transportation package design. Since the data for shock-absorbing material characteristics is acquired by a static test in general, it is quite different to that of dynamic characteristics. And the dynamic characteristics data is hardly found in literature. In this study, a drop weight facility was designed and fabricated which produces an impact speed like that of free drop of 9 m height. Several materials considered for an impact limiter and impact limiter structures were tested by a drop weight facility to acquire a dynamic material characteristics data

Drop Weight Device Fabrication and Tests for a Dynamic Material Property of Shock-Absorbing Material and Structure in Transportation Package

Energy Technology Data Exchange (ETDEWEB)

Choi, Woo Seok; Jeon, Jea Eon; Han, Sang Hyeok; Lee, Sang Hoon; Seo, Ki Seok [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

2009-05-15

A radioactive material transportation package consists of canister and impact limiters. IAEA Safety Standard Series No. TS-R-1 recommends a drop test to evaluate the structural integrity of a transportation package under a hypothetical accident condition. The free drop test of a transportation package from 9 m height simulates one of accident conditions. The transportation package has a potential energy corresponding to 9 m drop height, and this energy changes to a kinetic energy when it impacts on the target. The energy is absorbed by a deformation of shock-absorbing material so that the minimum energy is transferred to canister. Accordingly, the shock-absorbing material is a very important part in transportation package design. Since the data for shock-absorbing material characteristics is acquired by a static test in general, it is quite different to that of dynamic characteristics. And the dynamic characteristics data is hardly found in literature. In this study, a drop weight facility was designed and fabricated which produces an impact speed like that of free drop of 9 m height. Several materials considered for an impact limiter and impact limiter structures were tested by a drop weight facility to acquire a dynamic material characteristics data.

RNA localization in Xenopus oocytes uses a core group of trans-acting factors irrespective of destination.

Science.gov (United States)

Snedden, Donald D; Bertke, Michelle M; Vernon, Dominic; Huber, Paul W

2013-07-01

The 3' untranslated region of mRNA encoding PHAX, a phosphoprotein required for nuclear export of U-type snRNAs, contains cis-acting sequence motifs E2 and VM1 that are required for localization of RNAs to the vegetal hemisphere of Xenopus oocytes. However, we have found that PHAX mRNA is transported to the opposite, animal, hemisphere. A set of proteins that cross-link to the localization elements of vegetally localized RNAs are also cross-linked to PHAX and An1 mRNAs, demonstrating that the composition of RNP complexes that form on these localization elements is highly conserved irrespective of the final destination of the RNA. The ability of RNAs to bind this core group of proteins is correlated with localization activity. Staufen1, which binds to Vg1 and VegT mRNAs, is not associated with RNAs localized to the animal hemisphere and may determine, at least in part, the direction of RNA movement in Xenopus oocytes.

Carotid Artery Intima-Media Thickness Predicts Major Cardiovascular Events During 7-Year Follow-Up in 64-Year-Old Women Irrespective of Other Glucometabolic Factors.

Science.gov (United States)

Schmidt, Caroline; Bergström, Göran

2017-07-01

Cardiovascular (CV) disease (CVD) is a leading cause of morbidity and mortality worldwide. Most CV events are caused by atherosclerosis. Diabetes and impaired glucose tolerance are associated with greater carotid intima-media thickness (IMT) and increased risk for CVD. The present study examined if common carotid artery IMT (CCAIMT) is predictive of CVD irrespective of glucose tolerance category and glycated hemoglobin (HbA1c) in a sample of 639 women with different glucose tolerance categories. During 7-year follow-up, 30 events in the cardiac and 32 events in the cerebral territory were documented. Unadjusted Cox hazard models showed that CCAIMT, glucose tolerance category, and HbA1c were associated with increased risk. An adjusted and extended model, including CCAIMT, glucose tolerance category, and HbA1c, showed that CCAIMT was still associated with events with an almost unchanged hazard ratio. In conclusion, this study suggests that CCAIMT is predictive of major CV events during 7-year follow-up, irrespective of glucose tolerance category, HbA1c, and other established risk factors in a cohort of 64-year-old women.

High temperature resistant materials and structural ceramics for use in high temperature gas cooled reactors and fusion plants

International Nuclear Information System (INIS)

Nickel, H.

1992-01-01

Irrespective of the systems and the status of the nuclear reactor development lines, the availability, qualification and development of materials are crucial. This paper concentrates on the requirements and the status of development of high temperature metallic and ceramic materials for core and heat transferring components in advanced HTR supplying process heat and for plasma exposed, high heat flux components in Tokamak fusion reactor types. (J.P.N.)

Studies of alumina additions in zirconia - magnesia

International Nuclear Information System (INIS)

Muccillo, R.

1987-01-01

Ionic conductivity measurements have been carried out in the 500 0 C - 1000 0 C temperature range in Mg - PSZ (Partially Stabilized Zirconia) with 0.5 to 10 mol % alumina additions. All specimens were prepared by pressing followed by pre - and sintering at 1000 0 C/2h and1450 0 C/4h, respectively. Thermal histerysis of the ionic conductivity have been detected, probably due to phase changes in the Mg-PSZ samples. The results show that alumina additions up to 2.1% enhances densification with no major variations in electrical resistivity values. (Author) [pt

Potassium N-Iodo p-Toluenesulfonamide (TsNIK, Iodamine-T): A New Reagent for the Oxidation of Hydrazones to Diazo Compounds

Science.gov (United States)

Nicolle, Simon M; Moody, Christopher J

2014-01-01

A new reagent for the oxidation of hydrazones to diazo compounds is described. N-Iodo p-toluenesulfonamide (TsNIK, iodamine-T) allows the preparation of α-diazoesters, α-diazoamides, α-diazoketones and α-diazophosphonates in good yield and in high purity after a simple extractive work-up. α-Diazoesters were also obtained in high yield from the corresponding ketones through a one-pot process of hydrazone formation/oxidation. PMID:24615944

A phase I/II study of Docetaxel/TS-1 with radiation for esophageal cancer patients. Step 1

International Nuclear Information System (INIS)

Matsumoto, Hideo; Hirai, Toshihiro; Hirabayashi, Youko

2006-01-01

The therapy 5-fluorouracil (FU) and cisplatin (CDDP) with radiation is thought to be the standard therapy for esophageal cancer patients by now. However, the therapy is associated with a comparatively high incidence of gastrointestinal disorders and requires hospitalization. We have proposed a new regimen of Docetaxel and TS-1 with radiation for maintaining of QOL and improving outcome. Step 1 of the clinical phase I/II study was conducted for 10 cases from May 2004 to March 2006. Treatment could be accomplished in all cases, and no treatment-related deaths or adverse events of grade 4 were observed in any case. As for hematotoxicity, one case had leucopenia of grade 3 and neutropenia of grade 2. As for non-hematotoxic adverse events, anorexia of grade 3 was recognized in one case of level 3. The response rate evaluated by RECIST was 66% (CR in 2 cases, PR in 4 cases,) and the rate based on the Guide Lines for the Clinical and Pathologic Studies on Carcinoma of Esophagus by the Japanese Society for Esophageal Cancer was 70% (CR in 3 cases, PR in 4 cases). We assumed that the recommended dosage of TXT was 30 mg/m 2 and that of TS-1 was 60 mg/m 2 with radiotherapy of 60 Gy. This combination therapy may be recommended because of fewer adverse events and a higher responsive rate than the standard therapies. We intend to continue this study to step 2 and 3, and to reveal the response rate and adverse events for more esophageal cancer patients. (author)

Work in the classrooms with European perspective: materials and resources for autonomus learning

Directory of Open Access Journals (Sweden)

Manuela RAPOSO RIVAS

2011-04-01

Full Text Available One of the key principles set forth in the bologna process is to focus teaching on students, by getting involved actively and independently in their learning process and in developing their skills. This requires the use of teaching and learning methods together with materials and resources to motivate and guide them. In this paper, we present three of them, from our experience in adapting the subject of «New Technologies Applied to education» to the ecTs system, which we have found useful for guiding and evaluating the learning process and promote the intended learning. These materials and resources are: «learning guides», the portfolio and the rubric.

Nimetage mõned suuremad nõmedused, mida üks ülemus teha saab? / Kairi Ütsmüts, Allan Rosenberg, Katriin Jüriska ... [jt.

Index Scriptorium Estoniae

2010-01-01

Küsimusele vastavad Swedbank Eesti infotehnoloogia projektijuht Kairi Ütsmüts, Aspiro Eesti müügijuht Allan Rosenberg, Uuskasutuskeskuse tegevjuht Katriin Jüriska, Tele2 toote- ja turundusjuht Reilika Ilp, GrabCAD'i omanik ja insener Indrek Narusk ning turismifirma Estfly omanik Vahur Mäe

Experimental data report for test TS-3 Reactivity Initiated Accident test in the NSRR with pre-irradiated BWR fuel rod

International Nuclear Information System (INIS)

Nakamura, Takehiko; Yoshinaga, Makio; Fujishiro, Toshio; Kobayashi, Shinsho; Yamahara, Takeshi; Sukegawa, Tomohide; Kikuchi, Teruo; Sobajima, Makoto.

1993-09-01

This report presents experimental data for Test TS-3 which was the third test in a series of Reactivity Initiated Accident (RIA) tests using pre-irradiated BWR fuel rods, performed in the Nuclear Safety Research Reactor (NSRR) in September, 1990. Test fuel rod used in the Test TS-3 was a short-sized BWR (7 x 7) type rod which was re-fabricated from a commercial rod irradiated in the Tsuruga Unit 1 power reactor of Japan Atomic Power Co. The fuel had an initial enrichment of 2.79 % and a burnup of 26 Gwd/tU. A pulse irradiation of the test fuel rod was performed under a cooling condition of stagnant water at atmospheric pressure and at ambient temperature which simulated a BWR's cold start-up RIA event. The energy deposition of the fuel rod in this test was evaluated to be 94 ± 4 cal/g · fuel (88 ± 4 cal/g · fuel in peak fuel enthalpy) and no fuel failure was observed. Descriptions on test conditions, test procedures, transient behavior of the test rod during the pulse irradiation, and results of pre-pulse and post-pulse irradiation examinations are described in this report. (author)

Refining Ovarian Cancer Test accuracy Scores (ROCkeTS): protocol for a prospective longitudinal test accuracy study to validate new risk scores in women with symptoms of suspected ovarian cancer

Science.gov (United States)

Sundar, Sudha; Rick, Caroline; Dowling, Francis; Au, Pui; Rai, Nirmala; Champaneria, Rita; Stobart, Hilary; Neal, Richard; Davenport, Clare; Mallett, Susan; Sutton, Andrew; Kehoe, Sean; Timmerman, Dirk; Bourne, Tom; Van Calster, Ben; Gentry-Maharaj, Aleksandra; Deeks, Jon

2016-01-01

Introduction Ovarian cancer (OC) is associated with non-specific symptoms such as bloating, making accurate diagnosis challenging: only 1 in 3 women with OC presents through primary care referral. National Institute for Health and Care Excellence guidelines recommends sequential testing with CA125 and routine ultrasound in primary care. However, these diagnostic tests have limited sensitivity or specificity. Improving accurate triage in women with vague symptoms is likely to improve mortality by streamlining referral and care pathways. The Refining Ovarian Cancer Test Accuracy Scores (ROCkeTS; HTA 13/13/01) project will derive and validate new tests/risk prediction models that estimate the probability of having OC in women with symptoms. This protocol refers to the prospective study only (phase III). Methods and analysis ROCkeTS comprises four parallel phases. The full ROCkeTS protocol can be found at http://www.birmingham.ac.uk/ROCKETS. Phase III is a prospective test accuracy study. The study will recruit 2450 patients from 15 UK sites. Recruited patients complete symptom and anxiety questionnaires, donate a serum sample and undergo ultrasound scored as per International Ovarian Tumour Analysis (IOTA) criteria. Recruitment is at rapid access clinics, emergency departments and elective clinics. Models to be evaluated include those based on ultrasound derived by the IOTA group and novel models derived from analysis of existing data sets. Estimates of sensitivity, specificity, c-statistic (area under receiver operating curve), positive predictive value and negative predictive value of diagnostic tests are evaluated and a calibration plot for models will be presented. ROCkeTS has received ethical approval from the NHS West Midlands REC (14/WM/1241) and is registered on the controlled trials website (ISRCTN17160843) and the National Institute of Health Research Cancer and Reproductive Health portfolios. PMID:27507231

Parameters for Building Materials Specifications in Lagos, Nigeria

Directory of Open Access Journals (Sweden)

Clement Oluwole Folorunso

2013-07-01

Full Text Available The responsibility of specifying materials for building construction purposes within Nigeria rests on the architects. Understanding the appropriate parameters for specifying building materials that could lead to immense financial proportion is required from the architects. The level of understanding and knowledge of architects is germane to the optimum performance of buildings throughout their life cycle. The methodology applied for this research involved the administration of a structured questionnaire on professional architects within the study area to determine the basis of their decision on the materials they specify or chose for building finishes. The parameters used to measure the specification of materials for finishes are client’s choice, cost, climatic compliance, and maintenance demand of materials. Findings show that the maintenance demand of materials is the most important factor that determines the specification of materials irrespective of the choice of client and climate. However, cost occupies a prominent role in the decision process. It also shows that most architects are not fully aware about the role of climate in determining the life cycle of materials in tropical environments. The compliance of materials to ever-changing climate does not constitute a major factor in the specification of materials in the area.

Qualification testing facility for packages to be used for transport and storage of radioactive materials

International Nuclear Information System (INIS)

Vieru, Gheorghe

2009-01-01

The radioactive materials (RAM) packaging have to comply to all modes and transport condition, routine or in accident conditions possibly to occur during transportation operations. It is well known that the safety in the transport of RAM is dependent on packaging appropriate for the contents being shipped rather than on operational and/or administrative actions required for the package. The quality of these packages - type A, B or C has to be proved by performing qualification tests in accordance with the ROMANIAN nuclear regulation conditions provided by CNCAN Order no. 357/22.12.2005- 'Norms for a Safe Transport of Radioactive Material', the IAEA Vienna Recommendation stipulated in the Safety standard TS-R-1- Regulation for the Safe Transport of Radioactive Material, 2005 Edition, and other applicable international recommendations. The paper will describe the components of the designed testing facilities, and the qualification testing to be performed for all type A, B and C packages subjected to the testing. In addition, a part of the qualification tests for a package (designed and manufactured in INR Pitesti) used for transport and storage of spent fuel LEU elements of a TRIGA nuclear reactor will be described and analyzed. Quality assurance and quality controls measures taken in order to meet technical specification provided by the design are also presented and commented. The paper concludes that the new Romanian Testing Facilities for RAM packages will comply with the national safe standards as well as with the IAEA applicable recommendation provided by the TS-R-1 safety standard. (author)

Collagen gel contraction serves to rapidly distinguish epithelial- and mesenchymal-derived cells irrespective of alpha-smooth muscle actin expression

DEFF Research Database (Denmark)

Nielsen, Helga Lind; Gudjonsson, Thorarinn; Villadsen, René

2004-01-01

Mesenchymal-like cells in the stroma of breast cancer may arise as a consequence of plasticity within the epithelial compartment, also referred to as epithelial-mesenchymal transition, or by recruitment of genuine mesenchymal cells from the peritumoral stroma. Cells of both the epithelial...... compartment and the stromal compartment express alpha smooth muscle actin (alpha-sm actin) as part of a myoepithelial or a myofibroblastic differentiation program, respectively. Moreover, because both epithelial- and mesenchymal-derived cells are nontumorigenic, other means of discrimination are warranted....... Here, we describe the contraction of hydrated collagen gels as a rapid functional assay for the distinction between epithelial- and mesenchymal-derived stromal-like cells irrespective of the status of alpha-sm actin expression. Three epithelial-derived cell lines and three genuine mesenchymal...

TS 13298 Çerçevesinde Kurumsal Bilgi Sistemleri ve Elektronik Belge Yönetimi Standartlarının Değerlendirilmesi: İçişleri Bakanlığı Örneği=The Evaluation of Enterprise Information Systems and Electronic Records Management Standards within the scope of TS 13298: A Case of the Ministry of Internal Affairs

Directory of Open Access Journals (Sweden)

Şahika Eroğlu

2014-12-01

Full Text Available Bilişim teknolojileri birçok alanda olduğu gibi kamu hizmetlerinin yapılandırılmasında ve vatandaş devlet ilişkilerinde de çeşitli değişimlere yol açmıştır. Bu kapsamda kurum hizmetlerinde kullanılan kurumsal bilgi sistemleri temel olarak elektronik belge yönetimi uygulamalarına dayanmaktadır. Çalışmada; belge yönetimi, kurumsal bilgi sistemleri ve elektronik belge yönetimi kapsamında ulusal mevzuat ve standartlar analiz edilerek- TS 13298 Elektronik Belge Yönetimi standardına dayanılarak geliştirilen bir değerlendirme aracıyla kurumların elektronik belge yönetimi programları için sistem gereksinimlerinin neler olduğu ve standarda uygunluk durumları belirlenmesi hedeflenmiştir. Bu noktadan hareketle TS 13298 standardı kapsamında geliştirilen ve 40 maddeden oluşan değerlendirme aracı, örnek bir uygulama olarak elektronik belge yönetimi uygulamalarının yoğunlukla gerçekleştirildiği İçişleri Bakanlığında uygulanmış ve söz konusu Bakanlığın elektronik belge yönetimi programının iyileştirilmesi gereken noktaları ve standarda uygunluk durumu analiz edilmiştir.\\As in many areas IT Technologies has led to various changes for the implementation of public services and relationships between the citizen and governments In this context, enterprise information systems used in enterprise services is mainly based on electronic document management applications. Document management, enterprise information systems, electronic document management and standards are analyzed under the national legislations in this study. In this respect, main aim of the study is to determining system requirements for electronic document management program in institutions and their suitability for TS13298 standard via an assessment tool developed in accordance to TS13298 Electronic Document Management Standard. From this point the assessment tool developed within the standart of TS13298 and consists of 40 items

Insulīna rezistence PCOS pacientēm un tās saistība ar citiem riska faktoriem (kardiovaskulāro slimību, cukura diabēts)

OpenAIRE

Gutņikovs, Oļegs

2014-01-01

Darba pamatojums: PCOS ir viena no biežākajām endokrinopātijām sievietēm reproduktīvajā vecumā. Pēc literatūras datiem, pacientēm ar PCOS pieaug KVS un cukura diabēta attīstības risks. Tāpēc šajā pētījumā tiek analizēts, vai šie dati attiecināmi arī uz Latvijas populāciju. Pētījuma mērķis: salīdzināt KVS attīstības risku PCOS pacientēm ar vispārējo populāciju Latvijas teritorijā. Materiāli un metodes: Retrospektīva pētījuma ietvaros tika analizētas slimības vēstures PCOS pacientēm (E28...

Scientific Communication for Positive Action: Do's and Don'ts

Science.gov (United States)

Sanquini, A.; Wood, M. M.

2015-12-01

Natural hazard presentations often highlight disasters that may ensue from natural processes when mitigation or preparedness actions are not taken. Examples include images of raging fires, collapsed buildings, and flooded urban areas. Research has shown that this makes presentations more interesting and more memorable. Such images are the stock and trade of disaster reporting by the media. Unfortunately, it may also trigger avoidance and denial in the audience, resulting in preparedness reduction; the opposite effect of what may have been intended by the speaker. Recent social research has provided insight into a better approach. The theory of communicating actionable risk posits that people will take action against hazards when they know what to do, think it would work, and know someone who did it. This approach was recently applied in an intervention designed to motivate earthquake-resistant construction in Kathmandu Valley, Nepal. Social theory further suggests that a tendency towards action is strengthened by hearing a consistent message over time, and by providing the audience with an appropriate opportunity to seek out relevant information. This presentation shows how, by taking this transdisciplinary step, scientists can make small changes in their hazard communication, thereby acting as positive influencers of change. A summary of "do's" and "don'ts" is given for reference. 1. Show examples of what to do. 2. Show effectiveness of actions. 3. Give sense of knowing someone who did it. 4. Deliver consistent message, repeatedly. 5. Give opportunity for more information. DON'T: 1. Make the disaster the star. 2. Contradict other communications.

THE DOUBLE-DEGENERATE NUCLEUS OF THE PLANETARY NEBULA TS 01: A CLOSE BINARY EVOLUTION SHOWCASE

International Nuclear Information System (INIS)

Tovmassian, Gagik; Richer, Michael G.; Yungelson, Lev; Rauch, Thomas; Suleimanov, Valery; Napiwotzki, Ralf; Stasinska, Grazyna; Tomsick, John; Wilms, Joern; Morisset, Christophe; Pena, Miriam

2010-01-01

We present a detailed investigation of SBS 1150+599A, a close binary star hosted by the planetary nebula PN G135.9+55.9 (TS 01). The nebula, located in the Galactic halo, is the most oxygen-poor known to date and is the only one known to harbor a double degenerate core. We present XMM-Newton observations of this object, which allowed the detection of the previously invisible component of the binary core, whose existence was inferred so far only from radial velocity (RV) and photometric variations. The parameters of the binary system were deduced from a wealth of information via three independent routes using the spectral energy distribution (from the infrared to X-rays), the light and RV curves, and a detailed model atmosphere fitting of the stellar absorption features of the optical/UV component. We find that the cool component must have a mass of 0.54 ± 0.2 M sun , an average effective temperature, T eff , of 58,000 ± 3000 K, a mean radius of 0.43 ± 0.3 R sun , a gravity, log g = 5.0 ± 0.3, and that it nearly fills its Roche lobe. Its surface elemental abundances are found to be: 12 + log He/H = 10.95 ± 0.04 dex, 12 + log C/H = 7.20 ± 0.3 dex, 12 + log N/H eff = 160-180 kK, a luminosity of about ∼10 4 L sun and a radius slightly larger than that of a white dwarf. It is probably bloated and heated as a result of intense accretion and nuclear burning on its surface in the past. The total mass of the binary system is very close to the Chandrasekhar limit. This makes TS 01 one of the best Type Ia supernova progenitor candidates. We propose two possible scenarios for the evolution of the system up to its present stage.

TS-1 supported highly dispersed sub-5 nm gold nanoparticles toward direct propylene epoxidation using H2 and O2

Science.gov (United States)

Li, Naixu; Chen, Yong; Shen, Quanhao; Yang, Bin; Liu, Ming; Wei, Lingfei; Tian, Wei; Zhou, Jiancheng

2018-05-01

We report a simple and efficient method for the preparation of highly dispersed Au nanoparticles (< 5 nm) on TS-1 substrate. The synthesis relies on the use of NaBH4 as a reductant for rapid Au atom generation, as well as PVA as a capping agent confining the particle size and dispersion. The samples were characterized by N2 physisorption, inductively coupled plasma mass spectrometry, power X-ray diffraction, scanning electron microscopy, transmission electron microscopy, energy-dispersive X-ray spectroscopy, X-ray photoelectron spectroscopy, CO pulse chemisorption and thermogravimetric analysis. The size of Au particles can be controlled in the range of 3-5 nm. The supported catalyst shows both good activity and selectivity for propylene oxide (PO) generation from direct propylene epoxidation. An optimal performance with PO formation rate of 102.94 gPO h-1 kg-1cat and selectivity of 84.83% is achieved over 2.0 wt% Au/TS-1 catalyst, which is prepared by controlling PVA/Au3+ mass ratio of 1.5/1 and NaBH4/Au3+ mole ratio of 5/1. After 50 h test at 200 °C, no significant decrement of both catalytic activity and PO selectivity can be observed, indicating the excellent thermally stability of the catalyst. Furthermore, a possible reaction mechanism is described on basis of the previous researches and our experimental results.

Calculation of the nonlinear relativistic Thomson scattering fields and Its application to electron distribution function diagnostic

Science.gov (United States)

Guasp, J.; Pastor, I.; Álvarez-Estrada, R. F.; Castejón, F.

2015-02-01

Analytical results obtained recently of the ab-initio classical incoherent Thomson Scattering (TS) spectrum from a single-electron (Alvarez-Estrada et al 2012 Phys. Plasmas 19 062302) have been numerically implemented in a paralelized code to efficiently compute the TS emission from a given electron distribution function, irrespective of its characteristics and/or the intensity of the incoming radiation. These analytical results display certain differences, when compared with other authors, in the general case of incoming linearly and circularly polarized radiation and electrons with arbitrary initial directions. We regard such discrepancies and the ubiquitous interest in TS as motivations for this work. Here, we implement some analytical advances (like generalized Bessel functions for incoming linearly polarized radiation) in TS. The bulk of this work reports on the efficient computation of TS spectra (based upon our analytical approach), for an electron population having an essentially arbitrary distribution function and for both incoming linearly and circularly polarized radiation. A detailed comparison between the present approach and a previous Monte Carlo one (Pastor et al 2011 Nuclear Fusion 51 043011), dealing with the ab-initio computation of TS spectra, is reported. Both approaches are shown to fully agree with each other. As key computational improvements, the analytical technique yields a × 30 to × 100 gain in computation time and is a very flexible tool to compute the scattered spectrum and eventually the scattered electromagnetic fields in the time domain. The latter are computed explicitly here for the first time, as far as we know. Scaling laws for the power integrated over frequency versus initial kinetic energy are studied for the case of isotropic and monoenergetic electron distribution functions and their potential application as diagnostic tools for high-energy populations is briefly discussed. Finally, we discuss the application of these

Corrosion control of electronic materials; Denshi zairyo no fushoku seigyo gijutsu

Energy Technology Data Exchange (ETDEWEB)

Ishikawa, Y. [Hitachi Ltd., Tokyo (Japan). Mechanical Engineering Research Lab.

1995-11-20

Electronic materials are used in wide varieties of materials starting from hightech products like large computers, information network facilities and so forth, to vehicles, home electrical appliances, OA facilities, video game. Again, even though the part itself may be comparatively simple, high reliability is required when used in high degree system. Further, their uses irrespective to indoor or outdoor environments, are spread to wide range starting from the severe corrosive environments like coastal industrial area, drainage treatment place and so forth to low corrosive environments like general housing, offices and so forth. However, the classification of materials according to the environments where they are used is not so much carried out because preference is given to the function as an electronic part different to the large mechanical construction materials. In this report, regarding the corrosion control technology of electronic materials specially approach is made from material side, and among the various types of electronic materials, aluminium cable for LSI and magnetic materials are outlined. 37 refs., 10 figs., 2 tabs.

Crack phantoms: localized damage correlations and failure in network models of disordered materials

International Nuclear Information System (INIS)

Zaiser, M; Moretti, P; Lennartz-Sassinek, S

2015-01-01

We study the initiation of failure in network models of disordered materials such as random fuse and spring models, which serve as idealized representations of fracture processes in quasi-two-dimensional, disordered material systems. We consider two different geometries, namely rupture of thin sheets and delamination of thin films, and demonstrate that irrespective of geometry and implementation of the disorder (random failure thresholds versus dilution disorder) failure initiation is associated with the emergence of typical localized correlation structures in the damage patterns. These structures (‘crack phantoms’) exhibit well-defined characteristic lengths, which relate to the failure stress by scaling relations that are typical for critical crack nuclei in disorder-free materials. We discuss our findings in view of the fundamental nature of failure processes in materials with random microstructural heterogeneity. (paper)

Development of a molecular dynamic based cohesive zone model for prediction of an equivalent material behavior for Al/Al2O3 composite

Energy Technology Data Exchange (ETDEWEB)

Sazgar, A. [Center of Excellence in Design, Robotics and Automation, Department of Mechanical Engineering, Sharif University of Technology, Tehran (Iran, Islamic Republic of); Movahhedy, M.R., E-mail: movahhed@sharif.edu [Center of Excellence in Design, Robotics and Automation, Department of Mechanical Engineering, Sharif University of Technology, Tehran (Iran, Islamic Republic of); Mahnama, M. [School of Mechanical Engineering, University of Tehran, Tehran (Iran, Islamic Republic of); Sohrabpour, S. [Center of Excellence in Design, Robotics and Automation, Department of Mechanical Engineering, Sharif University of Technology, Tehran (Iran, Islamic Republic of)

2017-01-02

The interfacial behavior of composites is often simulated using a cohesive zone model (CZM). In this approach, a traction-separation (T-S) relation between the matrix and reinforcement particles, which is often obtained from experimental results, is employed. However, since the determination of this relation from experimental results is difficult, the molecular dynamics (MD) simulation may be used as a virtual environment to obtain this relation. In this study, MD simulations under the normal and shear loadings are used to obtain the interface behavior of Al/Al2O3 composite material and to derive the T-S relation. For better agreement with Al/Al2O3 interfacial behavior, the exponential form of the T-S relation suggested by Needleman [1] is modified to account for thermal effects. The MD results are employed to develop a parameterized cohesive zone model which is implemented in a finite element model of the matrix-particle interactions. Stress-strain curves obtained from simulations under different loading conditions and volume fractions show a close correlation with experimental results. Finally, by studying the effects of strain rate and volume fraction of particles in Al(6061-T6)/Al2O3 composite, an equivalent homogeneous model is introduced which can predict the overall behavior of the composite.

Analytic tests and their relation to jet fuel thermal stability

Energy Technology Data Exchange (ETDEWEB)

Heneghan, S.P.; Kauffman, R.E. [Univ. of Dayton Research Institute, OH (United States)

1995-05-01

The evaluation of jet fuel thermal stability (TS) by simple analytic procedures has long been a goal of fuels chemists. The reason is obvious: if the analytic chemist can determine which types of material cause his test to respond, the refiners will know which materials to remove to improve stability. Complicating this quest is the lack of an acceptable quantitative TS test with which to compare any analytic procedures. To circumvent this problem, we recently compiled the results of TS tests for 12 fuels using six separate test procedures. The results covering a range of flow and temperature conditions show that TS is not as dependent on test conditions as previously thought. Also, comparing the results from these tests with several analytic procedures shows that either a measure of the number of phenols or the total sulfur present in jet fuels is strongly indicative of the TS. The phenols have been measured using a cyclic voltammetry technique and the polar material by gas chromatography (atomic emission detection) following a solid phase extraction on silica gel. The polar material has been identified as mainly phenols (by mass spectrometry identification). Measures of the total acid number or peroxide concentration have little correlation with TS.

Association Between In-Office And At-Home Tooth Bleaching: A Single Blind Randomized Clinical Trial.

Science.gov (United States)

Rodrigues, João Lima; Rocha, Patrícia Souza; Pardim, Silvia Letícia de Souza; Machado, Ana Cláudia Vieira; Faria-E-Silva, André Luis; Seraidarian, Paulo Isaías

2018-01-01

This controlled randomized clinical trial evaluated the effect of associating at-home and in-office bleaching procedures on tooth sensitivity (TS) and bleaching effectiveness. Forty patients subjected to on session of in-office bleaching with 38% peroxide hydrogen. Subsequently, the patients were randomly allocated to receive a second session of in-office bleaching or to use a tray containing 10% carbamide peroxide delivered during 7 consecutive days. The worst TS score reported during or after each bleaching procedure was recorded using a verbal rating scale and TS risk (score different from 0) was calculated. Color changes were measured 7 days after each in-office session (for patients receiving in-office procedures only) or after the end of at-home bleaching (for the combined protocol), and 6 months after the last procedure for both bleaching protocols. Color was assessed by a spectrophotometer and by color match with the Vita Classical and Bleach guide scales. Statistical analyses were carried out to assess possible differences between the protocols regarding the outcomes and to analyze the effect of time of assessment on color changes. The bleaching protocol did not affect the risk for and the maximum level of TS reported, irrespective of the time of assessment. In the color evaluation, the bleaching protocol also did not affect the ultimate tooth color. In conclusion, after one in-office bleaching session, there was no difference in bleaching effectiveness and TS between performing a second in-office session and associating it with 1-week at-home bleaching.

Refining Ovarian Cancer Test accuracy Scores (ROCkeTS): protocol for a prospective longitudinal test accuracy study to validate new risk scores in women with symptoms of suspected ovarian cancer.

Science.gov (United States)

Sundar, Sudha; Rick, Caroline; Dowling, Francis; Au, Pui; Snell, Kym; Rai, Nirmala; Champaneria, Rita; Stobart, Hilary; Neal, Richard; Davenport, Clare; Mallett, Susan; Sutton, Andrew; Kehoe, Sean; Timmerman, Dirk; Bourne, Tom; Van Calster, Ben; Gentry-Maharaj, Aleksandra; Menon, Usha; Deeks, Jon

2016-08-09

Ovarian cancer (OC) is associated with non-specific symptoms such as bloating, making accurate diagnosis challenging: only 1 in 3 women with OC presents through primary care referral. National Institute for Health and Care Excellence guidelines recommends sequential testing with CA125 and routine ultrasound in primary care. However, these diagnostic tests have limited sensitivity or specificity. Improving accurate triage in women with vague symptoms is likely to improve mortality by streamlining referral and care pathways. The Refining Ovarian Cancer Test Accuracy Scores (ROCkeTS; HTA 13/13/01) project will derive and validate new tests/risk prediction models that estimate the probability of having OC in women with symptoms. This protocol refers to the prospective study only (phase III). ROCkeTS comprises four parallel phases. The full ROCkeTS protocol can be found at http://www.birmingham.ac.uk/ROCKETS. Phase III is a prospective test accuracy study. The study will recruit 2450 patients from 15 UK sites. Recruited patients complete symptom and anxiety questionnaires, donate a serum sample and undergo ultrasound scored as per International Ovarian Tumour Analysis (IOTA) criteria. Recruitment is at rapid access clinics, emergency departments and elective clinics. Models to be evaluated include those based on ultrasound derived by the IOTA group and novel models derived from analysis of existing data sets. Estimates of sensitivity, specificity, c-statistic (area under receiver operating curve), positive predictive value and negative predictive value of diagnostic tests are evaluated and a calibration plot for models will be presented. ROCkeTS has received ethical approval from the NHS West Midlands REC (14/WM/1241) and is registered on the controlled trials website (ISRCTN17160843) and the National Institute of Health Research Cancer and Reproductive Health portfolios. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted

Nonlinear process generating Tollmien-Schlichting waves in a reattached boundary layer; Hakuri saifuchaku nagare ni okeru T-S hado no hisenkei reiki katei

Energy Technology Data Exchange (ETDEWEB)

Asai, M.; Aiba, K. [Tokyo Metropolitan Institute of Technology, Tokyo (Japan)

1995-09-01

Low-frequency Tollmien-Schlichting (T-S) waves may be thought generated as a result of high-frequency disturbance between two proximity frequency modes grown unstably in a separation shear layer causing secondary nonlinear interference to occur. This fact has been verified by a numerical simulation. A non-compression Navier-Stokes equation was used for the fundamental equation, a tertiary windward difference for the convection term, and a secondary central difference for other differential calculus. The Reynolds number was 200, and the disturbance was introduced by applying `v` variation continuously on the wall face. Non-introduction of the disturbance results in a steady flow. Disturbance frequencies of 0.15 and 0.20 were selected as disturbance frequencies from the relationship between the spatial amplification and the frequency dependency. The structure of the excited disturbance agreed with the intrinsic mode. The difference mode due to nonlinear interference grows as the basic mode was amplified. The basic mode decays sharply in the boundary layer after reattachment, while the difference mode decays slowly. Distribution of the difference mode is a distribution of viscous T-S waves, which may be converted into the intrinsic mode. 8 refs., 7 figs.

Neural network and SVM classifiers accurately predict lipid binding proteins, irrespective of sequence homology.

Science.gov (United States)

Bakhtiarizadeh, Mohammad Reza; Moradi-Shahrbabak, Mohammad; Ebrahimi, Mansour; Ebrahimie, Esmaeil

2014-09-07

Due to the central roles of lipid binding proteins (LBPs) in many biological processes, sequence based identification of LBPs is of great interest. The major challenge is that LBPs are diverse in sequence, structure, and function which results in low accuracy of sequence homology based methods. Therefore, there is a need for developing alternative functional prediction methods irrespective of sequence similarity. To identify LBPs from non-LBPs, the performances of support vector machine (SVM) and neural network were compared in this study. Comprehensive protein features and various techniques were employed to create datasets. Five-fold cross-validation (CV) and independent evaluation (IE) tests were used to assess the validity of the two methods. The results indicated that SVM outperforms neural network. SVM achieved 89.28% (CV) and 89.55% (IE) overall accuracy in identification of LBPs from non-LBPs and 92.06% (CV) and 92.90% (IE) (in average) for classification of different LBPs classes. Increasing the number and the range of extracted protein features as well as optimization of the SVM parameters significantly increased the efficiency of LBPs class prediction in comparison to the only previous report in this field. Altogether, the results showed that the SVM algorithm can be run on broad, computationally calculated protein features and offers a promising tool in detection of LBPs classes. The proposed approach has the potential to integrate and improve the common sequence alignment based methods. Copyright © 2014 Elsevier Ltd. All rights reserved.

Proposed formation mechanism and active species of hydrogen molecules generated from a novel magnesium-citric acid-hydroxypropyl cellulose coating (MgCC) material

Science.gov (United States)

Kobayashi, Shigeki; Chikuma, Toshiyuki; Chiba, Kazuyoshi; Tsuchiya, Daisuke; Hirai, Tomomitsu

2016-02-01

The presence of acids is known to accelerate the reaction (Mg + 2H2O = Mg(OH)2 + H2). We developed a novel Mg-citric acid coating (MgCC) material produced by milling Mg powder coated with hydroxypropyl cellulose (HPC); because of its H2 generation, this material could be used in antioxidant therapy and antiaging applications. After milling in the presence of citric acid, this material produced H2-rich water upon addition to cooled water. Although the reaction was considered to involve a two-electron transfer from Mg to 2H2O, the role of the acid in H2 generation remains incompletely understood. To clarify the reaction mechanism, we performed studies on the deuterium kinetic isotope effects (KIE) and electron spin resonance (ESR). We observed differences in the concentration ratios, such as H2/D2 > 1 and H2/(H2 + D2 + HD) > 1, involved in H2, D2, and (H2 + D2 + HD) production, and found that adducts with hydrogen atoms (Hrad) were not obtained from the spin-trapping reaction between 5-(2, 2-Dimethyl-1,3-propoxy cyclophosphoryl)-5-methyl-1-pyrroline N-oxide (CYPMPO) and the MgCC material. The H2, D2, and HD produced from MgCC were identified by using a gas chromatograph connected to a mass spectrometer. The spin-trapping techniques showed that the Hrad adducts formed by the reaction of NaBH4 with CYPMPO could not be observed from reaction of MGCC with CYPMPO in H2O. The data suggest that the rate-controlling step and proposed transition state (TS) exist in the reaction pathway of the O-H bond cleavage and H-H bond formation. A TS of a structure such as [Mg(OH2)2]∗ could be expected in the reaction pathway between Mg and 2H2O by density functional theory calculations. Also, these results show that H2 generation is accelerated in the presence of acids because the activation energy of the TS is significantly smaller than that of H2O.

Study on Application of T-S Fuzzy Observer in Speed Switching Control of AUVs Driven by States

Directory of Open Access Journals (Sweden)

Xun Zhang

2014-01-01

Full Text Available Considering the inherent strongly nonlinear and coupling performance of autonomous underwater vehicles (AUVs, the speed switching control method for AUV driven by states is presented. By using T-S fuzzy observer to estimate the states of AUV, the speed control strategies in lever plane, vertical plane, and speed kept are established, respectively. Then the adaptive switching law is introduced to switch the speed control strategies designed in real time. In the simulation, acoustic Doppler current profile/side scan sonar (ADCP/SSS observation case is employed to demonstrate the effectiveness of the proposed method. The results show that the efficiency of AUV was improved, the trajectory tracking error was reduced, and the steady-state ability was enhanced.

Experimental R-curve behavior in partially stabilized zirconia using moiracute e interferometry

International Nuclear Information System (INIS)

Perry, K.E.; Okada, H.; Atluri, S.N.

1993-01-01

Moiracute e interferometry is employed to study toughening in partially stabilized zirconia (PSZ). Energy to fracture as a function of crack growth curves (R-curves) is derived from mode I compliance calculations and from near tip fitting of the moiracute e fringes. The effect of the tetragonal to monoclinic phase transformation in the zirconia is found by comparing the bulk compliance R-curves to the locally derived moiracute e R-curve. Localized strain field plots are produced from the moiracute e data for the PSZ zirconia. The observed transformation zone height compares favorably with that predicted by Okada et al. in a companion paper, as does the qualitative nature of the R-curve with predictions by Stump and Budiansky

QM/MM Free Energy Simulations of Salicylic Acid Methyltransferase: Effects of Stabilization of TS-like Structures on Substrate Specificity

Energy Technology Data Exchange (ETDEWEB)

Yao, Jianzhuang [University of Tennessee, Knoxville (UTK); Xu, Qin [University of Tennessee, Knoxville (UTK); Chen, Feng [University of Tennessee, Knoxville (UTK); Guo, Hong [University of Tennessee, Knoxville (UTK)

2010-01-01

Salicylic acid methyltransferases (SAMTs) synthesize methyl salicylate (MeSA) using salicylate as the substrate. MeSA synthesized in plants may function as an airborne signal to activate the expression of defense-related genes and could also be a critical mobile signaling molecule that travels from the site of plant infection to establish systemic immunity in the induction of disease resistance. Here the results of QM/MM free energy simulations for the methyl transfer process in Clarkia breweri SAMT (CbSAMT) are reported to determine the origin of the substrate specificity of SAMTs. The free energy barrier for the methyl transfer from S-adenosyl-l-methionine (AdoMet) to 4-hydroxybenzoate in CbSAMT is found to be about 5 kcal/mol higher than that from AdoMet to salicylate, consistent with the experimental observations. It is suggested that the relatively high efficiency for the methylation of salicylate compared to 4-hydroxybenzoate is due, at least in part, to the reason that a part of the stabilization of the transition state (TS) configuration is already reflected in the reactant complex, presumably, through the binding. The results seem to indicate that the creation of the substrate complex (e.g., through mutagenesis and substrate modifications) with its structure closely resembling TS might be fruitful for improving the catalytic efficiency for some enzymes. The results show that the computer simulations may provide important insights into the origin of the substrate specificity for the SABATH family and could be used to help experimental efforts in generating engineered enzymes with altered substrate specificity.

Impaired working memory capacity is not caused by failures of selective attention in schizophrenia.

Science.gov (United States)

Erickson, Molly A; Hahn, Britta; Leonard, Carly J; Robinson, Benjamin; Gray, Brad; Luck, Steven J; Gold, James

2015-03-01

The cognitive impairments associated with schizophrenia have long been known to involve deficits in working memory (WM) capacity. To date, however, the causes of WM capacity deficits remain unknown. The present study examined selective attention impairments as a putative contributor to observed capacity deficits in this population. To test this hypothesis, we used an experimental paradigm that assesses the role of selective attention in WM encoding and has been shown to involve the prefrontal cortex and the basal ganglia. In experiment 1, participants were required to remember the locations of 3 or 5 target items (red circles). In another condition, 3-target items were accompanied by 2 distractor items (yellow circles), which participants were instructed to ignore. People with schizophrenia (PSZ) exhibited significant impairment in memory for the locations of target items, consistent with reduced WM capacity, but PSZ and healthy control subjects did not differ in their ability to filter the distractors. This pattern was replicated in experiment 2 for distractors that were more salient. Taken together, these results demonstrate that reduced WM capacity in PSZ is not attributable to a failure of filtering irrelevant distractors. © The Author 2014. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oup.com.

Regulation of Transportation of Radioactive Material in Indonesia

International Nuclear Information System (INIS)

Nirwono, Muttaqin Margo; Choi, Kwang Sik

2011-01-01

1.1. Background Indonesia is a biggest archipelago country with 17,508 islands in 33 provinces. In transportation Indonesia has large number of airports, railways, roadways, waterways, and merchant marines. Since nuclear and radiation utilizations are expanding on whole country, the mobilization of these is usually placed outside of controlled facilities, in the public domain, and often entails movement between countries. The Indonesian Nuclear Energy Regulatory Agency (BAPETEN) is responsible for supervision and also authorization of the transport of radioactive material (TRM). TRM is the specific movement of a radioactive material consignment from origin to destination by public transportation (road or rail, water and air). This study aims to determine whether national regulation is harmonized with international practice in ensuring safety and security of TRM. The finding of this study will provide recommendation for enhancement of regulation on TRM. 1.2. Regulation of TRM in Indonesia Government Regulation (GR) No. 26, 2002 on the Safe Transport of Radioactive Material is implemented pursuant to Act 10, 1997 on Nuclear Energy. This GR was repealed GR 13, 1975 on TRM. The GR 26 consist of 16 chapters and 39 articles, included licensing: authority and responsibilities: packaging: radiation protection programme; training: quality assurance programme: type and activity limit of radioactive materials: radioactive materials with other dangerous properties: emergency preparedness: administrative sanction: and penal provisions. Principally, this GR adopted IAEA-TS-R-1, 'Regulations for the Safe Transport of Radioactive Material', 1996's Edition

Earlier saccades to task-relevant targets irrespective of relative gain between peripheral and foveal information.

Science.gov (United States)

Wolf, Christian; Schütz, Alexander C

2017-06-01

Saccades bring objects of interest onto the fovea for high-acuity processing. Saccades to rewarded targets show shorter latencies that correlate negatively with expected motivational value. Shorter latencies are also observed when the saccade target is relevant for a perceptual discrimination task. Here we tested whether saccade preparation is equally influenced by informational value as it is by motivational value. We defined informational value as the probability that information is task-relevant times the ratio between postsaccadic foveal and presaccadic peripheral discriminability. Using a gaze-contingent display, we independently manipulated peripheral and foveal discriminability of the saccade target. Latencies of saccades with perceptual task were reduced by 36 ms in general, but they were not modulated by the information saccades provide (Experiments 1 and 2). However, latencies showed a clear negative linear correlation with the probability that the target is task-relevant (Experiment 3). We replicated that the facilitation by a perceptual task is spatially specific and not due to generally heightened arousal (Experiment 4). Finally, the facilitation only emerged when the perceptual task is in the visual but not in the auditory modality (Experiment 5). Taken together, these results suggest that saccade latencies are not equally modulated by informational value as by motivational value. The facilitation by a perceptual task only arises when task-relevant visual information is foveated, irrespective of whether the foveation is useful or not.

Heterogeneous Ag-TiO2-SiO2 composite materials as novel catalytic systems for selective epoxidation of cyclohexene by H2O2.

Directory of Open Access Journals (Sweden)

Xin Wang

Full Text Available TiO2-SiO2 composites were synthesized using cetyl trimethyl ammonium bromide (CTAB as the structure directing template. Self-assembly hexadecyltrimethyl- ammonium bromide TiO2-SiO2/(CTAB were soaked into silver nitrate (AgNO3 aqueous solution. The Ag-TiO2-SiO2(Ag-TS composite were prepared via a precipitation of AgBr in soaking process and its decomposition at calcination stage. Structural characterization of the materials was carried out by various techniques including X-ray diffraction (XRD, scanning electron microscopy (SEM, transmission electron microscopy (TEM, N2 adsorption-desorption and ultraviolet visible spectroscopy (UV-Vis. Characterization results revealed that Ag particles were incorporated into hierarchical TiO2-SiO2 without significantly affecting the structures of the supports. Further heating-treatment at 723 K was more favorable for enhancing the stability of the Ag-TS composite. The cyclohexene oxide was the major product in the epoxidation using H2O2 as the oxidant over the Ag-TS catalysts. Besides, the optimum catalytic activity and stability of Ag-TS catalysts were obtained under operational conditions of calcined at 723 K for 2 h, reaction time of 120 min, reaction temperature of 353 K, catalyst amount of 80 mg, aqueous H2O2 (30 wt.% as oxidant and chloroform as solvent. High catalytic activity with conversion rate up to 99.2% of cyclohexene oxide could be obtainable in water-bathing. The catalyst was found to be stable and could be reused three times without significant loss of catalytic activity under the optimized reaction conditions.

Tetragonal to orthorhombic transformation in Mg-PSZ

International Nuclear Information System (INIS)

Liu, Z.W.; Spargo, A.E.C.; Hannink, R.H.J.; Drennan, J.

1997-01-01

The phase transformation from tetragonal to orthorhombic in MgO-partially-stabilized zirconia has been investigated by using high resolution transmission electron microscopy (HRTEM). Evidences are given to show that orthorhombic ZrO 2 frequently observed in transmission electron microscopy (TEM) thin foil studies was induced by dimpling and polishing during the specimen preparation. It was also found that the orthorhombic to monoclinic transformation was less sensitive to stress that the tetragonal to monoclinic transformation. 20 refs., 1 tab., 8 figs

Oxidized LDL Is Strictly Limited to Hyperthyroidism Irrespective of Fat Feeding in Female Sprague Dawley Rats

Directory of Open Access Journals (Sweden)

Sieglinde Zelzer

2015-05-01

Full Text Available Metabolic dysfunctions might play a crucial role in the pathophysiology of thyroid dysfunctions. This study aimed to investigate the impact of a controlled diet (normal versus high fat feeding on hypothyroid and hyperthyroid Sprague Dawley rats. Female Sprague Dawley rats (n = 66 were grouped into normal diet (n = 30 and high-fat diet (n = 36 groups and subdivided into controls, hypothyroid and hyperthyroid groups, induced through propylthiouracil or triiodothyronine (T3 treatment, respectively. After 12 weeks of treatment metabolic parameters, such as oxidized LDL (oxLDL, malondialdehyde (MDA, 4-hydroxynonenal (HNE, the lipid profile, body weight and food intake parameters were analyzed. Successfully induced thyroid dysfunctions were shown by T3 levels, both under normal and high fat diet. Thyroid dysfunctions were accompanied by changes in calorie intake and body weight as well as in the lipid profile. In detail, hypothyroid rats showed significantly decreased oxLDL levels, whereas hyperthyroid rats showed significantly increased oxLDL levels. These effects were seen under high fat diet and were less pronounced with normal feeding. Taken together, we showed for the first time in female SD rats that only hyper-, but not hypothyroidism, is associated with high atherogenic oxidized LDL irrespective of normal or high-fat diet in Sprague Dawley rats.

Oxidized LDL Is Strictly Limited to Hyperthyroidism Irrespective of Fat Feeding in Female Sprague Dawley Rats.

Science.gov (United States)

Zelzer, Sieglinde; Mangge, Harald; Pailer, Sabine; Ainoedhofer, Herwig; Kieslinger, Petra; Stojakovic, Tatjana; Scharnagl, Hubert; Prüller, Florian; Weghuber, Daniel; Datz, Christian; Haybaeck, Johannes; Obermayer-Pietsch, Barbara; Trummer, Christian; Gostner, Johanna; Gruber, Hans-Jürgen

2015-05-21

Metabolic dysfunctions might play a crucial role in the pathophysiology of thyroid dysfunctions. This study aimed to investigate the impact of a controlled diet (normal versus high fat feeding) on hypothyroid and hyperthyroid Sprague Dawley rats. Female Sprague Dawley rats (n = 66) were grouped into normal diet (n = 30) and high-fat diet (n = 36) groups and subdivided into controls, hypothyroid and hyperthyroid groups, induced through propylthiouracil or triiodothyronine (T3) treatment, respectively. After 12 weeks of treatment metabolic parameters, such as oxidized LDL (oxLDL), malondialdehyde (MDA), 4-hydroxynonenal (HNE), the lipid profile, body weight and food intake parameters were analyzed. Successfully induced thyroid dysfunctions were shown by T3 levels, both under normal and high fat diet. Thyroid dysfunctions were accompanied by changes in calorie intake and body weight as well as in the lipid profile. In detail, hypothyroid rats showed significantly decreased oxLDL levels, whereas hyperthyroid rats showed significantly increased oxLDL levels. These effects were seen under high fat diet and were less pronounced with normal feeding. Taken together, we showed for the first time in female SD rats that only hyper-, but not hypothyroidism, is associated with high atherogenic oxidized LDL irrespective of normal or high-fat diet in Sprague Dawley rats.

Web-based Training an deutschen Universitäts-Augenkliniken – Lehre 2.0? [Web-based Training in German University Eye Hospitals – Education 2.0?

Directory of Open Access Journals (Sweden)

Handzel, Daniel M.

2011-08-01

Full Text Available [english] Purpose: To analyse web-based training in ophthalmology offered by German university eye hospitals. Methods: In January 2010 the websites of all 36 German university hospitals were searched for information provided for visitors, students and doctors alike. We evaluated the offer in terms of quantity and quality. Results: All websites could be accessed at the time of the study. 28 pages provided information for students and doctors, one page only for students, three exclusively for doctors. Four pages didn’t offer any information for these target groups. The websites offered information on events like congresses or students curricular education, there were also material for download for these events or for other purposes. We found complex e-learning-platforms on 9 pages. These dealt with special ophthalmological topics in a didactic arrangement. In spite of the extensive possibilities offered by the technology of Web 2.0, many conceivable tools were only rarely made available. It was not always possible to determine if the information provided was up-to-date, very often the last actualization of the content was long ago. On one page the date for the last change was stated as 2004. Conclusion: Currently there are 9 functional e-learning-applications offered by German university eye hospitals. Two additional hospitals present links to a project of the German Ophthalmological Society. There was a considerable variation in quantity and quality. No website made use of crediting successful studying, e.g. with CME-points or OSCE-credits. All German university eye hospitals present themselves in the World Wide Web. However, the lack of modern, technical as well as didactical state-of-the-art learning applications is alarming as it leaves an essential medium of today’s communication unused. [german] Zielsetzung: Analyse der webbasierten ophthalmologischen Lernprogramme, welche von den Internetseiten der Universitäts-Augenkliniken in

Establishment and utilization of radiological protection programs for the transport of radioactive material; Establecimiento y utilizacion de programas de proteccion radiologica para el transporte de material radiactivo

Energy Technology Data Exchange (ETDEWEB)

Lopez V, J.; Capadona, N. [Autoridad Regulatoria Nuclear, Av. Del Libertador 8250 (1429) Buenos Aires, (Argentina)]. e-mail: jlvietri@sede.arn.gov.ar

2006-07-01

The present work has by objective to indicate rules for the establishment and the use of the Radiological Protection Programs (PPR) that are of application to the transport of radioactive materials according to that required by the Transport Regulation of the International Atomic Energy Agency (IAEA). The PPR are established and applied in systematic form for remittent, transport and addressees, to consider the measures of radiological protection and its appropriately control during the transport stages of radioactive material. In particular, in the work it is analyzed the PPR applied to the operative stage, in the one that can be considered as one of the more important documents to use since it summarizes the evaluations and the necessary controls of radiological protection. Also it is analyzed the importance that this document gets ready on the base that it converges in the the analyses, evaluations and data that have been kept in mind during the previous stages of design of bundles and production of packings, the types and quantities of involved bundles, as well as of considering the quantities of expeditions and its frequencies, the ways of transport, etc. It is included a brief description of the parts that the PPR conforms on the base of that suggested in the advanced draft of the TS-G-1.5 Guide 'Radiation Protection Programmes for Transport of Radioactive Material', of October, 2005, of the IAEA: objectives. necessity, scope, basic elements of a PPR in function of the occupational dose. assignment of functions and responsibilities for the establishment of a PPR, evaluation and dose optimization, surface contamination, segregation and other protection measures, responses in emergencies. training and administration systems for baled and transport of radioactive material. Next an example of PPR for the transport of bundles of the A Type by lorry with content of radiopharmaceuticals that are the bundles more used worldwide in the expeditions of

Crossing the Ts by case-story “Exploring moral distress in potential sibling stem cell donors"

DEFF Research Database (Denmark)

Kaltoft, Mette Kjer

Crossing the Ts by Exploring moral distress in potential sibling stem cell donors [1] Mette Kjer Kaltoft, Ph.d student, MPH, RN, Health Visitor University of Southern Denmark and Sydney School of Public Health Background: Catalysts aiming to reduce the burden of malignant disease by integrating...... off the benefits and harms specific to each stakeholder-context may increase live and posthumous donations without inflicting preventable harm. Reference: [1] Exploring moral distress in potential sibling stem cell donors, Nursing Ethics 20(2) 178-188, 2012 Begley A, Virtual University of Uganda......-type-test’) for enhanced decision quality and reduction of harm. Methods: A *case-story of siblings of a sick brother needing live donation is presented within an interactive model for prescriptive translation using a diagram and multi-criteria decision-analytic approach. Actual or projected results: You can see each...

T-S Fuzzy Model Based Control Strategy for the Networked Suspension Control System of Maglev Train

Directory of Open Access Journals (Sweden)

Guang He

2015-01-01

Full Text Available The control problem for the networked suspension control system of maglev train with random induced time delay and packet dropouts is investigated. First, Takagi-Sugeno (T-S fuzzy models are utilized to represent the discrete-time nonlinear networked suspension control system, and the parameters uncertainties of the nonlinear model have also been taken into account. The controllers take the form of parallel distributed compensation. Then, a sufficient condition for the stability of the networked suspension control system is derived. Based on the criteria, the state feedback fuzzy controllers are obtained, and the controller gains can be computed by using MATLAB LMI Toolbox directly. Finally, both the numerical simulations and physical experiments on the full-scale single bogie of CMS-04 maglev train have been accomplished to demonstrate the effectiveness of this proposed method.

Long-Run Diversion Effects of Changes in Truck Size and Weight (TS&W) Restrictions: An Update of the 1980 Friedlaender Spady Analysis

OpenAIRE

McCullough, Gerard J.

2013-01-01

The purpose of this analysis is to estimate the effect that revised truck size and weight (TS&W) restrictions would have on competitive rail-truck markets in the United States. The analysis is based on a classic study of the intercity freight markets that Ann Friedlaender and Richard Spady (FS) published in the Review of Economics and Statistics in 1980.1 The FS study provided a macro-level perspective on the freight markets by focusing on transportation decisions in key industrial sectors—fo...

Schedules of Provisions of the IAEA Regulations for the Safe Transport of Radioactive Material (2009 Ed.). Safety Guide

International Nuclear Information System (INIS)

2014-01-01

This Safety Guide is issued in support of Regulations for the Safe Transport of Radioactive Material (IAEA Safety Standards Series No. TS-R-1, 2009 Edition). It lists the paragraph numbers of the Transport Regulations that are relevant for specified types of consignment, classified according to their UN numbers. It does not provide additional recommendations. The intended users are consignors and consignees, carriers, shippers, regulators, and end users involved in the transport of radioactive material. A person or organization intending to transport a particular type of consignment of radioactive material must meet requirements in all sections of the Transport Regulations. This Safety Guide aids users by providing a listing of the relevant requirements of the Transport Regulations for each type of radioactive material, package or shipment. Once a consignor has classified the radioactive material to be shipped, the appropriate UN number can be assigned and the paragraph numbers of the requirements that apply for the shipment can be found in the corresponding schedule

Experience-dependent reduction of soluble β-amyloid oligomers and rescue of cognitive abilities in middle-age Ts65Dn mice, a model of Down syndrome.

Science.gov (United States)

Sansevero, Gabriele; Begenisic, Tatjana; Mainardi, Marco; Sale, Alessandro

2016-09-01

Down syndrome (DS) is the most diffused genetic cause of intellectual disability and, after the age of forty, is invariantly associated with Alzheimer's disease (AD). In the last years, the prolongation of life expectancy in people with DS renders the need for intervention paradigms aimed at improving mental disability and counteracting AD pathology particularly urgent. At present, however, there are no effective therapeutic strategies for DS and concomitant AD in mid-life people. The most intensively studied mouse model of DS is the Ts65Dn line, which summarizes the main hallmarks of the DS phenotype, included severe learning and memory deficits and age-dependent AD-like pathology. Here we report for the first time that middle-age Ts65Dn mice display a marked increase in soluble Aβ oligomer levels in their hippocampus. Moreover, we found that long-term exposure to environmental enrichment (EE), a widely used paradigm that increases sensory-motor stimulation, reduces Aβ oligomers and rescues spatial memory abilities in trisomic mice. Our findings underscore the potential of EE procedures as a non-invasive paradigm for counteracting brain aging processes in DS subjects. Copyright © 2016 Elsevier Inc. All rights reserved.

Trapping or tethering stones (TS: A multifunctional device in the Pastoral Neolithic of the Sahara.

Directory of Open Access Journals (Sweden)

Marina Gallinaro

Full Text Available The Pierres de Ben Barour, also known as trapping or tethering stones (TS, are stone artefacts with notches or grooves usually interpreted as hunting devices on the basis of rock art engravings. Though their presence is a peculiar feature of desert landscapes from the Sahara to the Arabian Peninsula, we know little about their age, context and function. Here we present a new approach to the study of these artefacts based on a large dataset (837 items recorded in the Messak plateau (SW Libya. A statistically-based geoarchaeological survey carried out between 2007 and 2011 in Libya, alongside landscape and intra-site analyses of specific archaeological features (such as rock art, settlement and ceremonial contexts, reveal that these artefacts were used for a prolonged period, probably from the early Holocene. This was followed by a multifunctional use of these devices, particularly during the Pastoral Neolithic phase (ca. 6400-3000 cal BC, with the highest concentrations being found near ceremonial contexts related to cattle burials.

Road accidents at night in the Netherlands : a national analysis according to official road accident data. Contribution to OECD Research Group TS 3 on Improving Road Safety at Night.

NARCIS (Netherlands)

Harris, S.

1979-01-01

The questionnaire about night-time accident data of the OECD Research Group TS 3 on Improving Road Safety at Night was filled in for the Netherlands. Thereafter a national analysis was written, using the already completed accident data questionnaire. Guidelines for the contents and presentation

Olanzapine is effective for refractory chemotherapy-induced nausea and vomiting irrespective of chemotherapy emetogenicity.

Science.gov (United States)

Vig, Sierra; Seibert, Laurel; Green, Myke R

2014-01-01

The role of olanzapine added to a dopamine antagonist and benzodiazepine for the treatment of refractory chemotherapy-induced nausea and vomiting (CINV) is incompletely characterized in all levels of chemotherapy emetogenicity. This retrospective study evaluated the efficacy of the addition of olanzapine in adults experiencing refractory CINV stratified by chemotherapy emetogenicity. Thirty-three adults who experienced CINV refractory to guideline-recommended prophylaxis and breakthrough antiemetics (dopamine antagonists and benzodiazepines) and received at least one dose of olanzapine 5-10 mg per os were evaluated. Failure was defined as >5 emesis events in 24 h or more than 10 cumulative doses of rescue antiemetics following first olanzapine dose per treatment cycle. Post hoc analyses investigated variables impacting olanzapine efficacy. The addition of olanzapine demonstrated an overall success rate of 70 %. This success rate did not differ between chemotherapy regimens of high versus low-to-moderate emetogenicity (p = 0.79), prophylaxis with serotonin antagonist plus corticosteroid and aprepitant versus serotonin antagonist alone (p = 0.77), or age over 50 versus ≤50 years (p > 0.99). A trend toward greater benefit was seen in women (p = 0.08). The addition of olanzapine to a dopamine antagonist and benzodiazepine demonstrated high efficacy rates for refractory CINV irrespective of chemotherapy emetogenicity. The high success rates among all groups suggests that incomplete resolution of CINV with prophylactic serotonin antagonists and breakthrough dopamine antagonists plus benzodiazepine may benefit from the addition of olanzapine regardless of gender, degree of chemotherapy emetogenicity, number of prophylactic antiemetics, or age. The trend toward greater control of emesis in women merits further investigation.

Denials and Delays of Radioactive Material Shipments

International Nuclear Information System (INIS)

El-Shinawy, R.M.K.

2011-01-01

delays of shipments of radioactive materials forms an important issue today. Radioactive materials need to be transported using all modes of transport for use in different applications such as public health, industry, research and production of nuclear power. The transport of radioactive materials is governed by national and international regulations, which are based on the International Atomic Energy Agency (IAEA) regulations for safe transport of radioactive materials (TS-R-1). These regulations ensure high standards of safety. Recently there were increasing numbers of instances of denials and delays of shipments of radioactive materials even when complying with the regulations. The denials and delays can result in difficulties to patients and others who rely on products sterilized by radiation. Therefore there is an urgent need for a universally accepted approach to solve this problem. In response, the IAEA has formed an International Steering Committee (ISC) on denials and delays of radioactive materials. Also, it designate the National Focal Points (NFP) representative to help the ISC members and the IAEA by informing about denial operations and how they can help. The Steering Committee developed and adopted an action plan which includes the action to be taken. This plan is based on: Awareness, Training, Communication, Lobbying for marketing, Economic and Harmonization among member states. It is important to work within the mandate of the ISC and in the line of action plan on denials and delays. It identified the following network members such as: National Focal Points, Regional Coordinators, National Committee, National Representative for different modes of transport and similar bodies, Carriers, Producers and Suppliers, Different civil societies, NGO's, Ministry of transport and others.

Short- and long-term effects of neonatal pharmacotherapy with epigallocatechin-3-gallate on hippocampal development in the Ts65Dn mouse model of Down syndrome.

Science.gov (United States)

Stagni, Fiorenza; Giacomini, Andrea; Emili, Marco; Trazzi, Stefania; Guidi, Sandra; Sassi, Martina; Ciani, Elisabetta; Rimondini, Roberto; Bartesaghi, Renata

2016-10-01

Cognitive disability is an unavoidable feature of Down syndrome (DS), a genetic disorder due to the triplication of human chromosome 21. DS is associated with alterations of neurogenesis, neuron maturation and connectivity that are already present at prenatal life stages. Recent evidence shows that pharmacotherapies can have a large impact on the trisomic brain provided that they are administered perinatally. Epigallocatechin-3-gallate (EGCG), the major polyphenol of green tea, performs many actions in the brain, including inhibition of DYRK1A, a kinase that is over-expressed in the DS brain and contributes to the DS phenotype. Young adults with DS treated with EGCG exhibit some cognitive benefits, although these effects disappear with time. We deemed it extremely important, however, to establish whether treatment with EGCG at the initial stages of brain development leads to plastic changes that outlast treatment cessation. In the current study, we exploited the Ts65Dn mouse model of DS in order to establish whether pharmacotherapy with EGCG during peak of neurogenesis in the hippocampal dentate gyrus (DG) enduringly restores hippocampal development and memory performance. Euploid and Ts65Dn mice were treated with EGCG from postnatal day 3 (P3) to P15. The effects of treatment were examined at its cessation (at P15) or after one month (at P45). We found that at P15 treated trisomic pups exhibited restoration of neurogenesis, total hippocampal granule cell number and levels of pre- and postsynaptic proteins in the DG, hippocampus and neocortex. However, at P45 none of these effects were still present, nor did treated Ts65Dn mice exhibit any improvement in hippocampus-dependent tasks. These findings show that treatment with EGCG carried out in the neonatal period rescues numerous trisomy-linked brain alterations. However, even during this, the most critical time window for hippocampal development, EGCG does not elicit enduring effects on the hippocampal physiology

Experimental verification of a GPC-LPV method with RLS and P1-TS fuzzy-based estimation for limiting the transient and residual vibration of a crane system

Science.gov (United States)

Smoczek, Jaroslaw

2015-10-01

The paper deals with the problem of reducing the residual vibration and limiting the transient oscillations of a flexible and underactuated system with respect to the variation of operating conditions. The comparative study of generalized predictive control (GPC) and fuzzy scheduling scheme developed based on the P1-TS fuzzy theory, local pole placement method and interval analysis of closed-loop system polynomial coefficients is addressed to the problem of flexible crane control. The two alternatives of a GPC-based method are proposed that enable to realize this technique either with or without a sensor of payload deflection. The first control technique is based on the recursive least squares (RLS) method applied to on-line estimate the parameters of a linear parameter varying (LPV) model of a crane dynamic system. The second GPC-based approach is based on a payload deflection feedback estimated using a pendulum model with the parameters interpolated using the P1-TS fuzzy system. Feasibility and applicability of the developed methods were confirmed through experimental verification performed on a laboratory scaled overhead crane.

PKCepsilon overexpression, irrespective of genetic background, sensitizes skin to UVR-induced development of squamous-cell carcinomas.

Science.gov (United States)

Sand, Jordan M; Aziz, Moammir H; Dreckschmidt, Nancy E; Havighurst, Thomas C; Kim, KyungMann; Oberley, Terry D; Verma, Ajit K

2010-01-01

Chronic exposure to UVR is the major etiologic factor in the development of human skin cancers including squamous-cell carcinoma (SCC). We have previously shown that protein Kinase C epsilon (PKCepsilon) transgenic mice on FVB/N background, which overexpress PKCepsilon protein approximately eightfold over endogenous levels in epidermis, exhibit about threefold more sensitivity than wild-type littermates to UVR-induced development of SCC. To determine whether it is PKCepsilon and not the mouse genetic background that determines susceptibility to UVR carcinogenesis, we cross-bred PKCepsilon FVB/N transgenic mice with SKH-1 hairless mice to generate PKCepsilon-overexpressing SKH-1 hairless mice. To evaluate the susceptibility of PKCepsilon SKH-1 hairless transgenic mice to UVR carcinogenesis, the mice were exposed to UVR (1-2 KJ m(-2)) three times weekly from a bank of six kodacel-filtered FS40 sunlamps. As compared with the wild-type hairless mice, PKCepsilon overexpression in SKH-1 hairless mice decreased the latency (12 weeks), whereas it increased the incidence (twofold) and multiplicity (fourfold) of SCC. The SKH hairless transgenic mice were observed to be as sensitive as FVB/N transgenic mice to UVR-induced development of SCC and expression of proliferative markers (proliferating cell nuclear antigen, signal transducers and activators of transcription 3, and extracellular signal-regulated kinase 1/2). The results indicate that PKCepsilon level dictates susceptibility, irrespective of genetic background, to UVR carcinogenesis.

Absorbing materials of thin film for photovoltaic structures prepared by the process of pyrolytic spraying; Materiales absorbedores en pelicula delgada para estructuras fotovoltaicas preparados por el proceso de rocio pirolitico

Energy Technology Data Exchange (ETDEWEB)

Calixto Rodriguez, Manuela

2006-11-15

In this thesis work thin semiconducting films were grown with the following compounds: In{sub 2}S{sub 3}, Ag{sub 2}S, AgInS{sub 2}, SnS{sub 2} and SnS with the pyrolytic spray technique. The structural, optical and electrical proposals of these films were analyzed to determine the set of deposit parameters in which are obtained the physical properties for the applications of the same in photovoltaic structures. It was found that the molar relation in solution of the departing compounds and the deposit temperature are the same dominant parameters in the process of growing the films. For the deposit of thin films of Indio acetate were used and N, N-dimetil tiourea as precursory compounds of In and S, respectively. Polycrystalline films were obtained from the compound In{sub 2}S{sub 3} using underlying temperatures, Ts, between 400 and 450 degrees Celsius, and Indio acetate solutions and N, N-dimetil tiourea with molar relations (In:S) of 1:8 and 1:1. The energy breach, Eg, of these films varies from 2.04 to 2.67 eV, and the value of the conductivity in the darkness, D varies from 10-7 to 1(cm)-1 in function of the molar relation in solution. It was found that the deposited films using a molar relation of In:S=1:8 are of intrinsic nature independently of Ts, while the ones deposited using a molar relations of In:S=1:1 and Ts 400 degrees Celsius posses type-n conductivity. Using the molar relation of I:S=1:1 and Ts=500 degrees Celsius the compound polycrystalline of In{sub 2}O{sub 3} is obtained whose optical and electrical properties are Eg {approx} 3 eV and D=11 (cm)-1, with electrical conductivity type-n. The deposited films using a molar relation of In:S=1:1 and Ts=450 degrees Celsius are the ones that keep the appropriate characteristics for their use as type-n material in photovoltaic structures (Eg=2eV and D=1?-1 com-1). [Spanish] En este trabajo de tesis se crecieron peliculas delgadas semiconductoras de los compuestos: In{sub 2}S{sub 3}, Ag{sub 2}S, Ag

Qualification testing facility for type A, B and C packages to be used for transport and storage of radioactive materials

International Nuclear Information System (INIS)

Vieru, G.; Nistor, V.; Vasile, A.; Cojocaru, V.

2009-01-01

In accordance with the Economic Commission for Europe-Committee on inland transport (ADR- European Agreement-concerning the international carriage of dangerous goods by road, 2007 Edition) the Safety and Security of the dangerous goods class No. 7 - Radioactive Materials during transport in all different modes - by road, by rail, by sea, by inland rivers or by air - have to be ensured at a very high level. The radioactive materials (RAM) packaging have to comply to all transport conditions, routine or in accident conditions, possibly to occur during transportation operations. It is well known that the safety in the transport of RAM is dependent on packaging appropriate for the contents being shipped rather than on operational and/or administrative actions required for the package. The quality of these packages - type A, B or C has to be proved by performing qualification tests in accordance with the Romanian nuclear regulation conditions provided by CNCAN Order no. 357/22.12.2005- N orms for a Safe Transport of Radioactive Material , the IAEA Vienna Recommendation (1, 2) stipulated in the Safety standard TS-R-1- Regulation for the Safe Transport of Radioactive Material, 2005 Edition, and other applicable international recommendations. The paper will describe the components of the designed testing facilities, and the qualification testing to be performed for all type A, B and C packages subjected to the testing Quality assurance and quality controls measures taken in order to meet technical specification provided by the design are also presented and commented. The paper concludes that the new Romanian Testing Facilities for RAM packages will comply with the national safe standards as well as with the IAEA applicable recommendation provided by the TS-R-1 safety standard. (authors)

Transient and intermittent magnetic reconnections in TS-3/UTST merging startup experiments

International Nuclear Information System (INIS)

Ono, Y.; Imazawa, R.; Imanaka, H.; Hayamizu, T.; Inomoto, M.; Sato, M.; Kawamori, E.; Ejiri, A.; Takase, Y.; Asai, T.; Takahashi, T.

2007-01-01

The high-power reconnection heating has been developed in the TS-3 merging experiments, leading us to a new pulsed high-beta spherical tokamak (ST) formation. Two ST plasmas were produced inductively by two or four PF coils without using any central solenoid (CS) coil and were merged together for MW-GW reconnection heating. The magnetic reconnection transformed the magnetic energy of reconnecting magnetic field through the outflow kinetic energy finally to the ion thermal energy, increasing the plasma beta of ST up to 0.5. A new finding is that ejection of current sheet (or plasmoid) causes high-speed merging/ reconnection as well as high-power heating. In the high-q ST merging, the sheet resistivity was almost classical due to the sheet thickness much longer than ion gyroradius. Large inflow flux and low current-sheet dissipation resulted in flux pileup followed by rapid growth of the current sheet. When the flux pileup exceeded a critical limit, the sheet was ejected mechanically from the squeezed X-point area. The reconnection (outflow) speed was slow during the flux pileup and was fast during the ejection, indicating that intermittent reconnection similar to the solar flare increased the averaged reconnection speed. These transient effects enable us to have the fast reconnection as well as the high-power reconnection heating, even if the merging high-q tokamaks have low current-sheet resistivity. (author)

Planning and Preparing for Emergency Response to Transport Accidents Involving Radioactive Material. Safety Guide

International Nuclear Information System (INIS)

2009-01-01

This Safety Guide provides guidance on various aspects of emergency planning and preparedness for dealing effectively and safely with transport accidents involving radioactive material, including the assignment of responsibilities. It reflects the requirements specified in Safety Standards Series No. TS-R-1, Regulations for the Safe Transport of Radioactive Material, and those of Safety Series No. 115, International Basic Safety Standards for Protection against Ionizing Radiation and for the Safety of Radiation Sources. Contents: 1. Introduction; 2. Framework for planning and preparing for response to accidents in the transport of radioactive material; 3. Responsibilities for planning and preparing for response to accidents in the transport of radioactive material; 4. Planning for response to accidents in the transport of radioactive material; 5. Preparing for response to accidents in the transport of radioactive material; Appendix I: Features of the transport regulations influencing emergency response to transport accidents; Appendix II: Preliminary emergency response reference matrix; Appendix III: Guide to suitable instrumentation; Appendix IV: Overview of emergency management for a transport accident involving radioactive material; Appendix V: Examples of response to transport accidents; Appendix VI: Example equipment kit for a radiation protection team; Annex I: Example of guidance on emergency response to carriers; Annex II: Emergency response guide.

TS-EUROTRAIN: A European-wide investigation and training network on the aetiology and pathophysiology of Gilles de la Tourette Syndrome

Directory of Open Access Journals (Sweden)

Natalie J Forde

2016-08-01

Full Text Available Gilles de la Tourette Syndrome (GTS is characterised by the presence of multiple motor and phonic tics with a fluctuating course of intensity, frequency and severity. Up to 90% of patients with GTS present with comorbid conditions, most commonly attention-deficit/hyperactivity disorder (ADHD and obsessive-compulsive disorder (OCD, thus providing an excellent model for the exploration of shared aetiology across disorders. TS-EUROTRAIN (FP7-PEOPLE-2012-ITN, Grant Agr.No.316978 is a Marie Curie Initial Training Network (http://ts-eurotrain.eu that aims to elucidate the complex aetiology of the onset and clinical course of GTS, investigate the neurobiological underpinnings of GTS and related disorders, translate research findings into clinical applications and establish a pan-European infrastructure for the study of GTS. This includes the challenges of (i assembling a large genetic database for the evaluation of the genetic architecture with high statistical power; (ii exploring the role of gene-environment interactions including the effects of epigenetic phenomena; (iii employing endophenotype-based approaches to understand the shared aetiology between GTS, OCD and ADHD; (iv establishing a developmental animal model for GTS; (v gaining new insights into the neurobiological mechanisms of GTS via cross-sectional and longitudinal neuroimaging studies; and (vi partaking in outreach activities including the dissemination of scientific knowledge about GTS to the public. Fifteen partners from academia and industry and twelve PhD candidates pursue the project. Our ultimate aims are to elucidate the complex aetiology and neurobiological underpinnings of GTS, translate research findings into clinical applications and establish Pan-European infrastructure for the study of GTS and associated disorders.

Safe and Secure Transportation of Radioactive Materials in Pakistan and Future Challenges

International Nuclear Information System (INIS)

Muneer, Muhammad; Ejaz, Asad

2016-01-01

PNRA is the sole organization in the country responsible to regulate all matters pertaining to ionizing radiations. For the safety of transport of radioactive material in the country, PNRA has adopted IAEA TS-R-1 as a national regulation. To cover the security aspects and emergency situations, if any, during the transportation of radioactive material, PNRA has issued the regulatory guide on ‘Transportation of Radioactive Material by Road in Pakistan’. In Pakistan, low to medium activity radioactive sources are transported from one place to another by road for the purpose of industrial radiography, well logging, medical application, etc. According to national policy, sealed radioactive sources of half life greater than 1 year and with initial activity of 100 GBq or more imported in the country are required to be returned to country of origin (exported) after its use. Although the activities related to transport of radioactive material remained safe and secure and no major accident/incident has been reported so far, however, the improvement/enhancement in the regulatory infrastructure is a continuous process. In future, more challenges are expected to be faced in the safety of transport packages. This paper will describe the steps taken by PNRA for the safety and security of transport of radioactive material in the country and future challenges. (author)

Replacing -CH2CH2- with -CONH- does not significantly change rates of charge transport through Ag(TS)-SAM//Ga2O3/EGaIn junctions.

Science.gov (United States)

Thuo, Martin M; Reus, William F; Simeone, Felice C; Kim, Choongik; Schulz, Michael D; Yoon, Hyo Jae; Whitesides, George M

2012-07-04

This paper describes physical-organic studies of charge transport by tunneling through self-assembled monolayers (SAMs), based on systematic variations of the structure of the molecules constituting the SAM. Replacing a -CH(2)CH(2)- group with a -CONH- group changes the dipole moment and polarizability of a portion of the molecule and has, in principle, the potential to change the rate of charge transport through the SAM. In practice, this substitution produces no significant change in the rate of charge transport across junctions of the structure Ag(TS)-S(CH(2))(m)X(CH(2))(n)H//Ga(2)O(3)/EGaIn (TS = template stripped, X = -CH(2)CH(2)- or -CONH-, and EGaIn = eutectic alloy of gallium and indium). Incorporation of the amide group does, however, increase the yields of working (non-shorting) junctions (when compared to n-alkanethiolates of the same length). These results suggest that synthetic schemes that combine a thiol group on one end of a molecule with a group, R, to be tested, on the other (e.g., HS~CONH~R) using an amide-based coupling provide practical routes to molecules useful in studies of molecular electronics.

Unwanted road to anaemia in transthyretin familial amyloid polyneuropathy may continue irrespective of tafamidis treatment.

Science.gov (United States)

Ikeda, Tokunori; Masuda, Teruaki; Ueda, Mitsuharu; Yamashita, Taro; Misumi, Yohei; Shinriki, Satoru; Ando, Yukio

2018-01-01

Background This retrospective longitudinal study was performed to determine whether tafamidis treatment leads to improvements in commonly used blood data for transthyretin familial amyloid polyneuropathy (TTR-FAP). Methods Commonly used blood data (complete blood count [including a haemogram], total protein, albumin, blood urea nitrogen, creatinine, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, lactate dehydrogenase, γ-glutamyl transpeptidase, total bilirubin [T-Bil], creatine kinase, choline esterase, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, estimated glomerular filtration rate [eGFR], serum amyloid A protein, TTR, haemoglobin A1c, free triiodothyronine [FT3] and free thyroxine [FT4]) were investigated in 33 TTR-FAP patients. These values included longitudinal data at three time points: six months before or after tafamidis treatment and one year after tafamidis treatment. Longitudinal changes in each blood item were examined using a linear mixed model, adjusting for age at starting tafamidis, sex, TTR-FAP stage and value before tafamidis treatment. Results Our results show elevated TTR concentrations after tafamidis treatment. In contrast, haemoglobin, mean corpuscular haemoglobin, mean corpuscular haemoglobin concentration, mean platelet volume, platelet distribution width, T-Bil, eGFR, FT3 and FT4, gradually decreased through a reference range. There were no characteristic observations in any other items. TTR binds to thyroid hormone; therefore, FT3 and FT4 decreased in inverse proportion to increased TTR concentrations. Conclusion Unfortunately, progression to anaemia may occur regardless of tafamidis treatment. Because anaemia is sometimes present in TTR-FAP, attention should be paid to longitudinal changes in commonly used blood data, irrespective of tafamidis treatment.

Stability Analysis and Stabilization of T-S Fuzzy Delta Operator Systems with Time-Varying Delay via an Input-Output Approach

Directory of Open Access Journals (Sweden)

Zhixiong Zhong

2013-01-01

Full Text Available The stability analysis and stabilization of Takagi-Sugeno (T-S fuzzy delta operator systems with time-varying delay are investigated via an input-output approach. A model transformation method is employed to approximate the time-varying delay. The original system is transformed into a feedback interconnection form which has a forward subsystem with constant delays and a feedback one with uncertainties. By applying the scaled small gain (SSG theorem to deal with this new system, and based on a Lyapunov Krasovskii functional (LKF in delta operator domain, less conservative stability analysis and stabilization conditions are obtained. Numerical examples are provided to illustrate the advantages of the proposed method.

The Epoxidation of Limonene over the TS-1 and Ti-SBA-15 Catalysts

Directory of Open Access Journals (Sweden)

Agnieszka Wróblewska

2014-11-01

Full Text Available Limonene belongs to a group of very important intermediates used in the production of fine chemicals. This monoterpene compound can be obtained from peels of oranges or lemon which are a (biomass waste from the orange juice industry. Thus, limonene is a renewable, easy available and a relatively cheap compound. This work presents preliminary studies on the process of limonene epoxidation over zeolite type catalysts such as: TS-1 and Ti-SBA-15. In these studies methanol was used as a solvent and as an oxidizing agent a 60 wt % hydrogen peroxide solution was applied. The activity of each catalyst was investigated for four chosen temperatures (0 °C, 40 °C, 80 °C and 120 °C. The reaction time was changed from 0.5 to 24 h. For each catalyst the most beneficial conditions (the appropriate temperature and the reaction time have been established. The obtained results were compared and the most active catalyst was chosen. These studies have also shown different possible ways of limonene transformation, not only in the direction of 1,2-epoxylimonene and its corresponding diol, but also in direction of carveol, carvone and perillyl alcohol—compounds with a lot of applications. The possible mechanisms of formation of the allylic oxidation products were proposed.

Simulated Aging of Spacecraft External Materials on Orbit

Science.gov (United States)

Khatipov, S.

Moscow State Engineering Physics Institute (MIFI), in cooperation with Air Force Research Laboratory's Satellite Assessment Center (SatAC), the European Office of Aerospace Research and Development (EOARD), and the International Science and Technology Center (ISTC), has developed a database describing the changes in optical properties of materials used on the external surfaces of spacecraft due to space environmental factors. The database includes data acquired from tests completed under contract with the ISTC and EOARD, as well as from previous Russian materials studies conducted within the last 30 years. The space environmental factors studied are for those found in Low Earth Orbits (LEO) and Geosynchronous orbits (GEO), including electron irradiation at 50, 100, and 200 keV, proton irradiation at 50, 150, 300, and 500 keV, and ultraviolet irradiation equivalent to 1 sun-year. The material characteristics investigated were solar absorption (aS), spectral reflectance (rl), solar reflectance (rS), emissivity (e), spectral transmission coefficient (Tl), solar transmittance (TS), optical density (D), relative optical density (D/x), Bi-directional Reflectance Distribution Function (BRDF), and change of appearance and color in the visible wavelengths. The materials tested in the project were thermal control coatings (paints), multilayer insulation (films), and solar cells. The ability to predict changes in optical properties of spacecraft materials is important to increase the fidelity of space observation tools, better understand observation of space objects, and increase the longevity of spacecraft. The end goal of our project is to build semi-empirical mathematical models to predict the long-term effects of space aging as a function of time and orbit.

Establishment and utilization of radiological protection programs for the transport of radioactive material

International Nuclear Information System (INIS)

Lopez V, J.; Capadona, N.

2006-01-01

The present work has by objective to indicate rules for the establishment and the use of the Radiological Protection Programs (PPR) that are of application to the transport of radioactive materials according to that required by the Transport Regulation of the International Atomic Energy Agency (IAEA). The PPR are established and applied in systematic form for remittent, transport and addressees, to consider the measures of radiological protection and its appropriately control during the transport stages of radioactive material. In particular, in the work it is analyzed the PPR applied to the operative stage, in the one that can be considered as one of the more important documents to use since it summarizes the evaluations and the necessary controls of radiological protection. Also it is analyzed the importance that this document gets ready on the base that it converges in the the analyses, evaluations and data that have been kept in mind during the previous stages of design of bundles and production of packings, the types and quantities of involved bundles, as well as of considering the quantities of expeditions and its frequencies, the ways of transport, etc. It is included a brief description of the parts that the PPR conforms on the base of that suggested in the advanced draft of the TS-G-1.5 Guide 'Radiation Protection Programmes for Transport of Radioactive Material', of October, 2005, of the IAEA: objectives. necessity, scope, basic elements of a PPR in function of the occupational dose. assignment of functions and responsibilities for the establishment of a PPR, evaluation and dose optimization, surface contamination, segregation and other protection measures, responses in emergencies. training and administration systems for baled and transport of radioactive material. Next an example of PPR for the transport of bundles of the A Type by lorry with content of radiopharmaceuticals that are the bundles more used worldwide in the expeditions of radioactive

“And time future contained in time past”: British Modernist Poetry from T.S. Eliot to Ted Hughes

Directory of Open Access Journals (Sweden)

Tatiana N. Krasavchenko

2017-09-01

Full Text Available It seems that T.S. Eliot (1888–1965 and Ted Hughes (1930–1998 are poets of different individual talents and epochs. Hughes, a poet of the second half of the 20 th century, concentrated on the conflict between Nature and the human being destroying Nature and thus preparing the end of the humanity. T.S. Eliot was a poet of urban civilization, a reformer of the Anglophone modernist poetry. In his days, the “poetry of Nature” rooted in the pastoral poetry of the 17 th –18 th centuries and in Romanticism, existed but only at the margins of mainstream poetic trends. Nevertheless, one can find it even in Eliot’s poetry, particularly in his Landscapes — poems written at the beginning of the 1930s. Also, both Eliot and Hughes were modernists. Eliot standing at the beginning of modernism, Hughes at its end; though the latter lived in the time of postmodernism, he was not a postmodernist himself since he was not engaged in the deconstruction and fragmentation of the “world model.” Like Eliot, he was a poet with integral Weltanschauung and a bright individual talent. Like Eliot, he was a traditionalist, though Eliot being an American was a “conscious traditionalist,” while Hughes, an Englishman, was most likely a “born” traditionalist: instead of deconstructing tradition, he was bearing on it. His “great tradition” included Shakespeare, Blake, Coleridge, Kipling, Graves, and Dylan Thomas. Both Eliot and Hughes are poets of eschatological trend and mythologists. However, one will not find Eliot among the authorities enlisted by Hughes in his “great tradition.” In the time of Hughes, Eliot was rejected due to the regular change of mainstreams trends. British poetry in the second half of the 20 th century is “tired” of urban poetry, of “Nature denial,” so it comes back to its track, and the motives that existed in Eliot’s poetry only in the background are now brought to the forefront.

Pressure gradient effect at distributed excitation of 3D TS waves by freestream and wall disturbances

Directory of Open Access Journals (Sweden)

Borodulin Vladimir

2017-01-01

Full Text Available The present work is a continuation of previous experiments (carried out in the Blasius boundary layer and devoted to quantitative investigation of influence of an adverse pressure gradient on two efficient mechanisms of excitation of 3D TS instability waves due to a distributed boundary layer receptivity to free-stream vortices. These mechanisms are associated with distributed scattering of 3D amplified free-stream vortices both on the natural boundary-layer nonuniformity (on smooth surface and on 2D surface nonuniformities (waviness. The corresponding detailed hotwire measurements were carried out in a self-similar boundary layer with Hartree parameter βH = –0.115 in a wide range of the problem parameters. Complex values of quantitative characteristics of the physical phenomenon under study (the distributed receptivity coefficients are evaluated by based on the obtained experimental data. It is found that the adverse pressure gradient leads to reduction of efficiency of the investigated vortexroughness receptivity mechanism.

Thermo-sensitive intelligent track membrane

International Nuclear Information System (INIS)

Pang Deling; Ren Lihua; Qian Zhilin; Huang Gang; Zhang Jinhua

1999-01-01

Using N-isopropylacryl-amide (NIP AAm) thermo-sensitive function material as monomer and nuclear track microporous membrane (NTMM) as baseline material, a thermo-sensitive intelligent track membrane (TsITM) has been prepared by the over-oxidization and pre-irradiation grafting techniques. The TsITM can be used to make a micro-switch controlled by temperature and to adjust particle screening and osmosis. To obtain sub-micron responsive grafted track pores only a very thin thermo-sensitive layer is needed. The TsITM pores are capable of swelling and shrinking rapidly and respond more sensitively to temperature

Status of the material capsule irradiation and the development of the new capsule technology in HANARO

International Nuclear Information System (INIS)

Choo, Kee-Nam; Kang, Young-Hwan; Choi, Myoung-Hwan; Cho, Man-Soon; Kim, Bong-Goo

2006-01-01

A material capsule system including a main capsule, fixing, control, cutting, and transport systems was developed for an irradiation test of non-fissile materials in HANARO. 14 irradiation capsules (12 instrumented and 2 non-instrumented capsules) have been designed, fabricated and successfully irradiated in the HANARO CT and IR test holes since 1995. The capsules were mainly designed for an irradiation of the RPV (Reactor Pressure Vessel), reactor core materials, and Zr-based alloys. Most capsules were made for KAERI material research projects, but 5 capsules were made as a part of national projects for the promotion of the HANARO utilization for universities. Based on the accumulated irradiation experience and the user's sophisticated requirements, development of new instrumented capsule technologies for a more precise control of the irradiation temperature and fluence of a specimen irrespective of the reactor operation has been performed in HANARO. (author)

Adenylylation of small RNA sequencing adapters using the TS2126 RNA ligase I.

Science.gov (United States)

Lama, Lodoe; Ryan, Kevin

2016-01-01

Many high-throughput small RNA next-generation sequencing protocols use 5' preadenylylated DNA oligonucleotide adapters during cDNA library preparation. Preadenylylation of the DNA adapter's 5' end frees from ATP-dependence the ligation of the adapter to RNA collections, thereby avoiding ATP-dependent side reactions. However, preadenylylation of the DNA adapters can be costly and difficult. The currently available method for chemical adenylylation of DNA adapters is inefficient and uses techniques not typically practiced in laboratories profiling cellular RNA expression. An alternative enzymatic method using a commercial RNA ligase was recently introduced, but this enzyme works best as a stoichiometric adenylylating reagent rather than a catalyst and can therefore prove costly when several variant adapters are needed or during scale-up or high-throughput adenylylation procedures. Here, we describe a simple, scalable, and highly efficient method for the 5' adenylylation of DNA oligonucleotides using the thermostable RNA ligase 1 from bacteriophage TS2126. Adapters with 3' blocking groups are adenylylated at >95% yield at catalytic enzyme-to-adapter ratios and need not be gel purified before ligation to RNA acceptors. Experimental conditions are also reported that enable DNA adapters with free 3' ends to be 5' adenylylated at >90% efficiency. © 2015 Lama and Ryan; Published by Cold Spring Harbor Laboratory Press for the RNA Society.

The System 80+ Standard Plant design control document. Volume 19

International Nuclear Information System (INIS)

1997-01-01

This Design Control Document (DCD) is a repository of information comprising the System 80+trademark Standard Plant Design. The DCD also provides that design-related information to be incorporated by reference in the design certification rule for the System 80+ Standard Plant Design. Applicants for a combined license pursuant to 10 CFR 52 must ensure that the final Design Certification Rule and the associated Statements of Consideration are used when making all licensing decisions relevant to the System 80+ Standard Plant Design. The Design Control Document contains the DCD introduction, The Certified Design Material (CDM) [i.e., ''Tier 1''] and the Approved Design Material (ADM) [i.e., ''Tier 2''] for the System 80+ Standard Plant Design. The CDM includes the following sections: (1) Introductory material; (2) Certified Design Material for System 80+ systems and structures; (3) Certified Design Material for non-system-based aspects of the System 80+ Certified design; (4) Interface requirements; and (5) Site parameters. The ADM, to the extent applicable for the System 80+ Standard Plant Design, includes: (1) the information required for the final safety analysis report under 20 CFR 50.34; (2) other relevant information required by 10 CFR 52.47; and (3) emergency operations guidelines. This volume contains five technical specification bases that are part of Appendix 16 A of the ADM Design and Analysis. They are: TS B3.3 Instrumentation Bases; TS B3.4 RCS Bases; TS B3.5 ECCS Bases; TS B3.6 Containment Systems Bases; and TS B3.7 Plant Systems Bases

MET signalling in primary colon epithelial cells leads to increased transformation irrespective of aberrant Wnt signalling

Science.gov (United States)

Boon, E M J; Kovarikova, M; Derksen, P W B; van der Neut, R

2005-01-01

It has been shown that in hereditary and most sporadic colon tumours, components of the Wnt pathway are mutated. The Wnt target MET has been implicated in the development of colon cancer. Here, we show that overexpression of wild-type or a constitutively activated form of MET in colon epithelial cells leads to increased transformation irrespective of Wnt signalling. Fetal human colon epithelial cells without aberrant Wnt signalling were transfected with wild-type or mutated MET constructs. Expression of these constructs leads to increased phosphorylation of MET and its downstream targets PKB and MAPK. Upon stimulation with HGF, the expression of E-cadherin is downregulated in wild-type MET-transfected cells, whereas cells expressing mutated MET show low E-cadherin levels independent of stimulation with ligand. This implies a higher migratory propensity of these cells. Furthermore, fetal human colon epithelial cells expressing the mutated form of MET have colony-forming capacity in soft agar, while cells expressing wild-type MET show an intermediate phenotype. Subcutaneous injection of mutated MET-transfected cells in nude mice leads to the formation of tumours within 12 days in all mice injected. At this time point, mock-transfected cells do not form tumours, while wild-type MET-transfected cells form subcutaneous tumours in one out of five mice. We thus show that MET signalling can lead to increased transformation of colon epithelial cells independent of Wnt signalling and in this way could play an essential role in the onset and progression of colorectal cancer. PMID:15785735

Oral supplementation of Bifidobacterium longum strain BR-108 alters cecal microbiota by stimulating gut immune system in mice irrespectively of viability.

Science.gov (United States)

Makioka, Yuko; Tsukahara, Takamitsu; Ijichi, Tetsuo; Inoue, Ryo

2018-03-20

Effect on cecal microbiota and gene expression of various cytokines in ileal Peyer's patches and cecal tissues were compared between viable and heat-killed Bifidobacterium longum strain BR-108 (BR-108) using a mouse model. Irrespectively of viability, oral supplementation of BR-108 altered the cecal microbiota and stimulated gene expression of cytokines such as IL-6 and IL-10 in ileal Peyer's patches and cecal tissue of mice. In addition, BR-108 supplementation significantly affected the relative abundance of bacterial genera and family, Oscillospira, Bacteroides and S24-7. The abundance of these bacterial genera and family strongly correlated with gene expression induced by BR-108. This study demonstrated that the effect of heat-killed BR-108 on the mouse cecal microbiota is similar to that of viable BR-108, most likely due to stimulation of the gut immune system by both heat-killed and viable BR-108 is also similar.

Human Adult Stem Cells Maintain a Constant Phenotype Profile Irrespective of Their Origin, Basal Media, and Long Term Cultures

Directory of Open Access Journals (Sweden)

Indumathi Somasundaram

2015-01-01

Full Text Available The study aims to identify the phenotypic marker expressions of different human adult stem cells derived from, namely, bone marrow, subcutaneous fat, and omentum fat, cultured in different media, namely, DMEM-Low Glucose, Alpha-MEM, DMEM-F12 and DMEM-KO and under long term culture conditions (>P20. We characterized immunophenotype by using various hematopoietic, mesenchymal, endothelial markers, and cell adhesion molecules in the long term cultures (Passages-P1, P3, P5, P9, P12, P15, and P20. Interestingly, data revealed similar marker expression profiles irrespective of source, basal media, and extensive culturing. This demonstrates that all adult stem cell sources mentioned in this study share similar phenotypic marker and all media seem appropriate for culturing these sources. However, a disparity was observed in the markers such as CD49d, CD54, CD117, CD29, and CD106, thereby warranting further research on these markers. Besides the aforesaid objective, it is understood from the study that immunophenotyping acts as a valuable tool to identify inherent property of each cell, thereby leading to a valuable cell based therapy.

BOILER MATERIALS FOR ULTRASUPERCRITICAL COAL POWER PLANTS

Energy Technology Data Exchange (ETDEWEB)

R. Viswanathan; K. Coleman; R.W. Swindeman; J. Sarver; J. Blough; W. Mohn; M. Borden; S. Goodstine; I. Perrin

2003-10-20

The principal objective of this project is to develop materials technology for use in ultrasupercritical (USC) plant boilers capable of operating with 760 C (1400 F), 35 MPa (5000 psi) steam. This project has established a government/industry consortium to undertake a five-year effort to evaluate and develop of advanced materials that allow the use of advanced steam cycles in coal-based power plants. These advanced cycles, with steam temperatures up to 760 C, will increase the efficiency of coal-fired boilers from an average of 35% efficiency (current domestic fleet) to 47% (HHV). This efficiency increase will enable coal-fired power plants to generate electricity at competitive rates (irrespective of fuel costs) while reducing CO{sub 2} and other fuel-related emissions by as much as 29%. Success in achieving these objectives will support a number of broader goals. First, from a national prospective, the program will identify advanced materials that will make it possible to maintain a cost-competitive, environmentally acceptable coal-based electric generation option. High sulfur coals will specifically benefit in this respect by having these advanced materials evaluated in high-sulfur coal firing conditions and from the significant reductions in waste generation inherent in the increased operational efficiency. Second, from a national prospective, the results of this program will enable domestic boiler manufacturers to successfully compete in world markets for building high-efficiency coal-fired power plants.

A flavonoid agonist of the TrkB receptor for BDNF improves hippocampal neurogenesis and hippocampus-dependent memory in the Ts65Dn mouse model of DS.

Science.gov (United States)

Stagni, Fiorenza; Giacomini, Andrea; Guidi, Sandra; Emili, Marco; Uguagliati, Beatrice; Salvalai, Maria Elisa; Bortolotto, Valeria; Grilli, Mariagrazia; Rimondini, Roberto; Bartesaghi, Renata

2017-12-01

Intellectual disability is the unavoidable hallmark of Down syndrome (DS), with a heavy impact on public health. Reduced neurogenesis and impaired neuron maturation are considered major determinants of altered brain function in DS. Since the DS brain starts at a disadvantage, attempts to rescue neurogenesis and neuron maturation should take place as soon as possible. The brain-derived neurotrophic factor (BDNF) is a neurotrophin that plays a key role in brain development by specifically binding to tropomyosin-related kinase receptor B (TrkB). Systemic BDNF administration is impracticable because BDNF has a poor blood-brain barrier penetration. Recent screening of a chemical library has identified a flavone derivative, 7,8-dihydroxyflavone (7,8-DHF), a small-molecule that crosses the blood-brain barrier and binds with high affinity and specificity to the TrkB receptor. The therapeutic potential of TrkB agonists for neurogenesis improvement in DS has never been examined. The goal of our study was to establish whether it is possible to restore brain development in the Ts65Dn mouse model of DS by targeting the TrkB receptor with 7,8-DHF. Ts65Dn mice subcutaneously injected with 7,8-DHF in the neonatal period P3-P15 exhibited a large increase in the number of neural precursor cells in the dentate gyrus and restoration of granule cell number, density of dendritic spines and levels of the presynaptic protein synaptophysin. In order to establish the functional outcome of treatment, mice were treated with 7,8-DHF from P3 to adolescence (P45-50) and were tested with the Morris Water Maze. Treated Ts65Dn mice exhibited improvement of learning and memory, indicating that the recovery of the hippocampal anatomy translated into a functional rescue. Our study in a mouse model of DS provides novel evidence that treatment with 7,8-DHF during the early postnatal period restores the major trisomy-linked neurodevelopmental defects, suggesting that therapy with 7,8-DHF may represent a

Heraclitean logos and flux in T.S. Eliot’s Four Quartets: 'cosmic consciousness' and 'the still point of the turning world'

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A. Wessels

2001-08-01

Full Text Available T.S. Eliot prefaces “Burnt Norton”, the first of his Four Quartets, with two quotations from the Greek philosopher, Heraclitus. By means of these epigrams, Eliot points us to the Heraclitean opposition and paradoxical interdependence between logos and flux as a paradigm in the poem, a paradigm that he uses for an investigation and articulation of a number of philosophical contemplations. In this paper, I discuss Eliot’s different configurations of the logos/flux paradigm in the poem, firstly to illuminate the relationship between temporality and eternity, secondly, to elaborate the relationship between God and humanity, and thirdly to express the relationship between structured art and chaotic experience. In each instance it is not only the opposition between the two elements that is important, but also the point of contact, the intersection. There is some evidence that Eliot’s depiction of this intersection as, for example, the “moment in and out of time”, is based on personal experience of a transcendent, mystical nature. His expression of this experience is also investigated by comparing it to similar experiences described by others, notably by a Canadian psychiatrist, Richard Maurice Bucke. A comparison of Bucke’s description in his evolutionist text of 1901 and Eliot’s poetic rendering reveals not only surprising similarities but also essential differences which highlights Eliot’s purely Christian interpretation in the face of Bucke’s more universalist approach. For T.S. Eliot, eternity or timelessness can only be accessed through the temporal experience of human consciousness, in fleeting moments of exaltation in daily life, in the charged, timeless configurations of art as an imitation of divine creation, and finally in Christ, who embodies the love of God and is for Eliot the ultimate transection of the temporal and eternal, the flux and the logos.

Irradiation behavior of graphite shielding materials for FBR

International Nuclear Information System (INIS)

Maruyama, Tadashi; Kaito, Takeji; Onose, Shoji; Shibahara, Itaru

1994-01-01

Thirteen kinds of isotropic graphites with different density and maximum grain size were irradiated in the experimental fast reactor 'JOYO' to fluences from 2.11 to 2.86x10 26 n/m 2 (E>0.1 MeV) at temperatures from 549 to 597degC. Postirradiation examination was carried out on dimensional change, elastic modulus, and the thermal conductivity. The result of measurement of dimensional change indicated that the graphites irradiated at lower fluences showed shrinkage upon neutron irradiation followed by increase with increasing neutron fluences, irrespective of differences in material parameters. The Young's modulus and Poisson's ratio increased to two to three times of unirradiated values. A large scatter found in Poisson's ratio of unirradiated materials became very small and a linear dependency on density was obtained after irradiation. The thermal conductivity decreased to one-fifth to one-tenth of unirradiated values, but the change in specific heat was negligibly small. The results of postirradiation examination indicated that the changes in physical properties of high density, isotropic graphites were mainly dominated by the irradiation condition rather than their material parameters. Namely, the effects of irradiation induced defects on physical properties of heavily neutron-irradiated graphites are much larger than that of defects associated with as-fabricated specimens. (author)

Development of assessment methods for transport and storage containers with higher content of metallic recycling material

International Nuclear Information System (INIS)

Zencker, U.; Qiao Linan; Droste, B.

2004-01-01

The mechanical behaviour of transport and storage containers made of ductile cast iron melted with higher content of metallic recycling material from decommissioning and dismantling of nuclear installations is investigated. With drop tests of cubic container-like models, the influence of different real targets on the stresses in the cask body and the fracture behaviour is examined. A test stand foundation is suggested, which can be manufactured simply and improves the reproducibility of the test results strongly. The test objects are partially equipped with artificial cracklike defects. Dynamic fracture mechanics analyses of these defects were performed by means of finite element calculations to uncover safety margins. Numerous test results show depending on the requirements that containers for final disposal can be built by means of a ductile cast iron with fracture toughness more than half under the lower bound value for the licensed material qualities yet. The application limits of the material are determined also by the opportunities of the safety assessment methods. This project supports the application of brittle fracture safe transport and storage packages for radioactive materials as recommended in App. VI of the Advisory Material for the IAEA Regulations for the Safe Transport of Radioactive Material (IAEA No. TS-G-1.1)

Development of assessment methods for transport and storage containers with higher content of metallic recycling material

Energy Technology Data Exchange (ETDEWEB)

Zencker, U.; Qiao Linan; Droste, B. [Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin (Germany)

2004-07-01

The mechanical behaviour of transport and storage containers made of ductile cast iron melted with higher content of metallic recycling material from decommissioning and dismantling of nuclear installations is investigated. With drop tests of cubic container-like models, the influence of different real targets on the stresses in the cask body and the fracture behaviour is examined. A test stand foundation is suggested, which can be manufactured simply and improves the reproducibility of the test results strongly. The test objects are partially equipped with artificial cracklike defects. Dynamic fracture mechanics analyses of these defects were performed by means of finite element calculations to uncover safety margins. Numerous test results show depending on the requirements that containers for final disposal can be built by means of a ductile cast iron with fracture toughness more than half under the lower bound value for the licensed material qualities yet. The application limits of the material are determined also by the opportunities of the safety assessment methods. This project supports the application of brittle fracture safe transport and storage packages for radioactive materials as recommended in App. VI of the Advisory Material for the IAEA Regulations for the Safe Transport of Radioactive Material (IAEA No. TS-G-1.1).

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Thermal formation of corundum from aluminium hydroxides prepared from various aluminium salts · J Temuujin Ts ... Gas-chromism in ultrasonic spray pyrolyzed tungsten oxide thin films ... Current–voltage studies on -FeSi2/Si heterojunction.

Incidence de la clarification des moûts de raisin sur les fermentescibilltés alcoolique et malolactique

Directory of Open Access Journals (Sweden)

Michèle Guilloux-Benatier

1993-12-01

Full Text Available Des essais de débourbage en vinification en blanc, réalisés de 1988 à 1992, mettent en évidence le rôle important joué par la teneur en macromolécules solubles dans le moût de raisin. Les moûts de faible turbidité conduisent en effet à des fermentations alcooliques lentes en relation avec de faibles populations levuriennes. Il est également confirmé que la libération de polysaccharides exocellulaires par les levures au cours de la fermentation alcoolique est d'autant plus élevée que le moût de départ a été fortement appauvri en colloïdes de raisin. Par contre, ce sont dans les lots les plus clarifiés que l'on observe la meilleure fermentescibilité malolactique.

Early postoperative alterations of ventilation parameters after tracheostomy in major burn injuries

Directory of Open Access Journals (Sweden)

Mailänder, Peter

2010-01-01

Full Text Available Purpose: In patients with major burn injuries mechanical ventilation is often required for longer periods. Tracheostomy (TS plays an integral role in airway management. We investigated the effect of TS on ventilation parameters within 8 hours after TS. Materials: A retrospective analysis of severely burned patients admitted to the burn unit of a German University Hospital was performed. Ventilation parameters 8 hours before and after TS were registered. Results: A retrospective analysis of 20 patients which received surgical TS was performed. Mean age was 52±19 years. Mean abbreviated burned severity index (ABSI was 8.3±2.2. A mechanical ventilation was required for 14.3±4.8 days. TS was performed on day 7±4. Inspiratory oxygen concentration (FiO2 (p<0.001, peak inspiratory pressure (p<0.001, positive end-expiratory pressure (p=0.003 and pulmonary resistance (p<0.001 were reduced significantly after TS. The arterial partial pressure of oxygen/FiO2-ratio increased significantly after TS (p<0.001. Conclusions: We demonstrate that TS reduces invasiveness of ventilation in severely burned patients and by this can optimize lung protective ventilation strategy.

Precipitation in partially stabilized zirconia

International Nuclear Information System (INIS)

Bansal, G.K.

1975-01-01

Transmission electron microscopy was used to study the substructure of partially stabilized ZrO 2 (PSZ) samples, i.e., 2-phase systems containing both cubic and monoclinic modifications of zirconia, after various heat treatments. Monoclinic ZrO 2 exists as (1) isolated grains within the polycrystalline aggregate (a grain- boundary phase) and (2) small plate-like particles within cubic grains. These intragranular precipitates are believed to contribute to the useful properties of PSZ via a form of precipitation hardening. These precipitates initially form as tetragonal ZrO 2 , with a habit plane parallel to the brace 100 brace matrix planes. The orientation relations between the tetragonal precipitates and the cubic matrix are brace 100 brace/sub matrix/ 2 parallel brace 100 brace /sub precipitate/ or (001)/sub precipitate/ and broken bracket 100 broken bracket/sub matrix/ 2 parallel broken bracket 100 broken bracket/sub precipitate/ or [001]/sub precipitate/. (U.S.)

The System 80+ Standard Plant design control document. Volume 17

International Nuclear Information System (INIS)

1997-01-01

This Design Control Document (DCD) is a repository of information comprising the System 80+trademark Standard Plant Design. The DCD also provides that design-related information to be incorporated by reference in the design certification rule for the System 80+ Standard Plant Design. Applicants for a combined license pursuant to 10 CFR 52 must ensure that the final Design Certification Rule and the associated Statements of Consideration are used when making all licensing decisions relevant to the System 80+ Standard Plant Design. The Design Control Document contains the DCD introduction, The Certified Design Material (CDM) [i.e., ''Tier 1''] and the Approved Design Material (ADM) [i.e., ''Tier 2''] for the System 80+ Standard Plant Design. The CDM includes the following sections: (1) Introductory material; (2) Certified Design Material for System 80+ systems and structures; (3) Certified Design Material for non-system-based aspects of the System 80+ Certified design; (4) Interface requirements; and (5) Site parameters. The ADM, to the extent applicable for the System 80+ Standard Plant Design, includes: (1) the information required for the final safety analysis report under 20 CFR 50.34; (2) other relevant information required by 10 CFR 52.47; and (3) emergency operations guidelines. This volume contains parts 2-7 and appendix 15A for section 15 (Accident Analysis) of the ADM Design and Analysis. Topics covered in these parts are: decrease in heat removal; decrease in RCS flow rate; power distribution anomalies; increase in RCS inventory; decrease in RCS inventory; release of radioactive materials. The appendix covers radiological release models. Also contained here are five technical specifications for section 16 (Technical Specifications) of the ADM Design and Analysis. They are: TS 1.0 Use and Applications; TS 2.0 Safety Limits; TS 3.0 LCO Availability; TS 3.1 Reactivity Control; and TS 3.2 Power Distribution

Modern trends in engineering ceramics: review of transformation toughening in zirconia based ceramics

International Nuclear Information System (INIS)

Khan, A.A.

1998-01-01

The investigation of zirconia has continued to attract the interest of ever increasing number of scientists and solid evidence of commercial applications for the engineering ceramic is now available. To use zirconia to its full potential, the properties of the oxide have been modified extensively by the addition of cubic stabilizing oxides. These can be added in amounts sufficient to form a partially stabilized zirconia (PSZ) or to form a fully stabilized zirconia, which has a cubic structure at room temperature. The addition of varying amounts of cubic oxides, particularly MgO, CaO, Y sub 2 O sub 3, has allowed the development of novel and innovative ceramic materials. In this article an overview of the recent advances in zirconia based engineering materials is presented. It is shown that intelligent control of the composition and microstructure can lead the the production of extremely though ceramic materials, a property which is generally thought to be the major weak point of ceramics vis a vis other class of materials. (author)

Amniotic membranes as prosthetic material: experimental utilization data of a rat model.

Science.gov (United States)

Zachariou, Z

1997-10-01

Prosthetic materials are applied for closing big tissue defects, the repair of traumatized organs, or hernias. Because nonabsorbable synthetic materials are rigid, possess a defined and unchangeable size, and foreign body reaction (FBR) may occur, biological materials may be an alternative. In experimental studies in rats the authors implanted the fetal parts of the human amniotic membranes and examined the utilization and FBR induced in a standardized model. In addition amnion (AM) was combined with vicryl-net (VN) for higher implant stability. Fifteen, 30 and 90 days after implantation, macroscopic appearance was examined, and light microscopy and immunohistology testing of the specimens were performed. Adhesions to parenchymal organs and omentum were present irrespective of the side facing the abdominal cavity. AM induced a rapid FBR, which diminished with time. Chorion (CH) and parts of the AM were resorbed within the examined period after infiltration with recipient cells and neovascularisation. The combined implant, AM, and VN showed best results because disadvantages of one material could be compensated for by the advantages of the other. The studies show that AM, in its anatomic definition, combined with VN proves to be a safe and reliable prosthetic material for the use in tissue defects.

The anaerobic digestion of pig carcase with or without sugar beet pulp, as a novel on-farm disposal method.

Science.gov (United States)

Kirby, Marie E; Theodorou, Michael K; Brizuela, Carole M; Huntington, James A; Powles, Jayne; Wilkinson, Robert G

2018-05-01

Anaerobic digestion was investigated as a potential method for on-farm disposal of fallen stock (pig carcases), degrading the carcase material to produce biogas and digestate. The effects of feedstock (sugar beet pulp or pig carcase material or a 50:50 mix) and organic loading rate (50 g-TS L -1 or 100 g-TS L -1 ), during mesophilic (35 °C) anaerobic digestion were investigated. Anaerobic digestion was achieved for all experimental treatments, however the pig carcase material at the higher organic loading rate produced the second highest methane yield (0.56 Nm 3 kg-VS -1 versus a range of 0.14-0.58 Nm 3 kg-VS -1 for other treatments), with the highest percentage of methane in total biogas (61.6% versus a range of 36.1-55.2% for all other treatments). Satisfactory pathogen reduction is a legislative requirement for disposal of carcase material. Pathogens were quantified throughout the anaerobic digestion process. Enterococcus faecalis concentrations decreased to negligible levels (2.8 log 10 CFU g-TS -1 ), whilst Clostridium perfringens levels remained unaffected by treatment throughout the digestion process (5.3 ± 0.2 log 10 CFU g-TS -1 ). Copyright © 2018 Elsevier Ltd. All rights reserved.

Effect of pyrolysis atmospheres on the morphology of polymer-derived silicon oxynitrocarbide ceramic films coated aluminum nitride surface and the thermal conductivity of silicone rubber composites

Science.gov (United States)

Chiu, Hsien T.; Sukachonmakul, Tanapon; Wang, Chen H.; Wattanakul, Karnthidaporn; Kuo, Ming T.; Wang, Yu H.

2014-02-01

Amorphous silicon oxycarbide (SiOC) and silicon oxynitrocarbide (SiONC) ceramic films coated aluminum nitride (AlN) were prepared by using preceramic-polysilazane (PSZ) with dip-coating method, followed by pyrolysis at 700 °C in different (air, Ar, N2 and NH3) atmospheres to converted PSZ into SiOCair and SiONC(Ar,N2andNH3) ceramic. The existence of amorphous SiOCair and SiONC(Ar,N2andNH3) ceramic films on AlN surface was characterized by FTIR, XRD and XPS. The interfacial adhesion between silicone rubber and AlN was significantly improved after the introduction of amorphous SiOCair and SiONC(Ar,N2andNH3) ceramic films on AlN surface. It can be observed from AFM that the pyrolysis of PSZ at different atmosphere strongly affected to films morphology on AlN surface as SiOCair and SiONCNH3 ceramic films were more flat and smooth than SiONCN2 and SiONCAr ceramic films. Besides, the enhancement of the thermal conductivity of silicone rubber composites was found to be related to the decrease in the surface roughness of SiOCair and SiONC(Ar,N2andNH3) ceramic films on AlN surface. This present work provided an alternative surface modification of thermally conductive fillers to improve the thermal conductivity of silicon rubber composites by coating with amorphous SiOCair and SiONC(Ar,N2andNH3) ceramic films.

Transient subcritical crack-growth behavior in transformation-toughened ceramics

International Nuclear Information System (INIS)

Dauskardt, R.H.; Ritchie, R.O.; Carter, W.C.; Veirs, D.K.

1990-01-01

Transient subcritical crack-growth behavior following abrupt changes in the applied load are studied in transformation-toughened ceramics. A mechanics analysis is developed to model the transient nature of transformation shielding of the crack tip, K s , with subcritical crack extension following the applied load change. conditions for continued crack growth, crack growth followed by arrest, and no crack growth after the load change, are considered and related to the magnitude and sign of the applied load change and to materials properties such as the critical transformation stress. The analysis is found to provide similar trends in K s compared to values calculated from experimentally measured transformation zones in a transformation-toughened Mg-PSZ. In addition, accurate prediction of the post load-change transient crack-growth behavior is obtained using experimentally derived steady-state subcritical crack-growth relationships for cyclic fatigue in the same material

Travelling TexTs alla Nordic Digital Humanities Conference: Riflessioni sulla situazione di Digital Humanities nell’ottica della storia letteraria finlandese

Directory of Open Access Journals (Sweden)

Viola Parente-Čapková

2016-12-01

Full Text Available In my contribution, I intend to offer a report on the first conference of Nordic Digital Humanities held in Oslo on March 15-17 2016. I begin with a brief note on the present situation of the discipline, and, following the arguments brought up during the conference, reflect on its existence, development and problems. Then I concentrate on the presentation of the HERA funded Joint Research Project Travelling TexTs 1790–1914: Transnational Reception of Women’s Writing at the Fringes of Europe (Finland, Norway, Slovenia, Spain, The Netherlands and the importance of the digital tool for the project work. I tackle the concept of distant and close reading and comment briefly on the possibilities which such projects offer in terms of new ways of writing and teaching (Finnish literary history.

SVM-Prot 2016: A Web-Server for Machine Learning Prediction of Protein Functional Families from Sequence Irrespective of Similarity.

Science.gov (United States)

Li, Ying Hong; Xu, Jing Yu; Tao, Lin; Li, Xiao Feng; Li, Shuang; Zeng, Xian; Chen, Shang Ying; Zhang, Peng; Qin, Chu; Zhang, Cheng; Chen, Zhe; Zhu, Feng; Chen, Yu Zong

2016-01-01

Knowledge of protein function is important for biological, medical and therapeutic studies, but many proteins are still unknown in function. There is a need for more improved functional prediction methods. Our SVM-Prot web-server employed a machine learning method for predicting protein functional families from protein sequences irrespective of similarity, which complemented those similarity-based and other methods in predicting diverse classes of proteins including the distantly-related proteins and homologous proteins of different functions. Since its publication in 2003, we made major improvements to SVM-Prot with (1) expanded coverage from 54 to 192 functional families, (2) more diverse protein descriptors protein representation, (3) improved predictive performances due to the use of more enriched training datasets and more variety of protein descriptors, (4) newly integrated BLAST analysis option for assessing proteins in the SVM-Prot predicted functional families that were similar in sequence to a query protein, and (5) newly added batch submission option for supporting the classification of multiple proteins. Moreover, 2 more machine learning approaches, K nearest neighbor and probabilistic neural networks, were added for facilitating collective assessment of protein functions by multiple methods. SVM-Prot can be accessed at http://bidd2.nus.edu.sg/cgi-bin/svmprot/svmprot.cgi.

A Golay complementary TS-based symbol synchronization scheme in variable rate LDPC-coded MB-OFDM UWBoF system

Science.gov (United States)

He, Jing; Wen, Xuejie; Chen, Ming; Chen, Lin

2015-09-01

In this paper, a Golay complementary training sequence (TS)-based symbol synchronization scheme is proposed and experimentally demonstrated in multiband orthogonal frequency division multiplexing (MB-OFDM) ultra-wideband over fiber (UWBoF) system with a variable rate low-density parity-check (LDPC) code. Meanwhile, the coding gain and spectral efficiency in the variable rate LDPC-coded MB-OFDM UWBoF system are investigated. By utilizing the non-periodic auto-correlation property of the Golay complementary pair, the start point of LDPC-coded MB-OFDM UWB signal can be estimated accurately. After 100 km standard single-mode fiber (SSMF) transmission, at the bit error rate of 1×10-3, the experimental results show that the short block length 64QAM-LDPC coding provides a coding gain of 4.5 dB, 3.8 dB and 2.9 dB for a code rate of 62.5%, 75% and 87.5%, respectively.

T-S Fuzzy Model-Based Approximation and Filter Design for Stochastic Time-Delay Systems with Hankel Norm Criterion

Directory of Open Access Journals (Sweden)

Yanhui Li

2014-01-01

Full Text Available This paper investigates the Hankel norm filter design problem for stochastic time-delay systems, which are represented by Takagi-Sugeno (T-S fuzzy model. Motivated by the parallel distributed compensation (PDC technique, a novel filtering error system is established. The objective is to design a suitable filter that guarantees the corresponding filtering error system to be mean-square asymptotically stable and to have a specified Hankel norm performance level γ. Based on the Lyapunov stability theory and the Itô differential rule, the Hankel norm criterion is first established by adopting the integral inequality method, which can make some useful efforts in reducing conservativeness. The Hankel norm filtering problem is casted into a convex optimization problem with a convex linearization approach, which expresses all the conditions for the existence of admissible Hankel norm filter as standard linear matrix inequalities (LMIs. The effectiveness of the proposed method is demonstrated via a numerical example.

Functional materials - Study of process for CVD SiC/C composite material

Energy Technology Data Exchange (ETDEWEB)

Choi, Doo Jin; Wang, Chae Chyun; Lee, Young Jin; Oh, Byung Jun [Yonsei University, Seoul (Korea)

2000-04-01

The CVD SiC coating techniques are the one of high functional material manufactures that improve the thermal, wear, oxidization and infiltration resistance of the surface of raw materials and extend the life of material. Silicon carbide films have been grown onto graphite substrates by low pressure chemical vapor deposition using MTS(CH{sub 3}SiCl{sub 3}) as a source precursor and H{sub 2} or N{sub 2} as a diluent gas. The experiments for temperature and diluent gas addition changes were performed. The effect of temperature from 900 deg. C to 1350 deg. C and the alteration of diluent gas species on the growth rate and structure of deposits have been studied. The experimental results showed that the deposition rate increased with increasing deposition temperature irrespective of diluent gases and reactant depletion effect increased especially at H{sub 2} diluent gas ambient. As the diluent gas added, the growth rate decreased parabolically. For N{sub 2} addition, surface morphology of leaf-like structure appeared, and for H{sub 2}, faceted structure at 1350 deg. C. The observed features were involved by crystalline phase of {beta}-SiC and surface composition with different gas ambient. We also compared the experimental results of the effect of partial pressure on the growth rate with the results of theoretical approach based on the Langmuir-Hinshelwood model. C/SiC composites were prepared by isothermal chemical vapor infiltration (ICVI). In order to fabricate the more dense C/SiC composites, a novel process of the in-situ whisker growing and filling during ICVI was devised, which was manipulated by alternating dilute gas species. The denser C/SiC composites were successfully prepared by the novel process comparing with the conventional ICVI process. 64 refs., 36 figs., 5 tabs. (Author)

Optimized Energy Harvesting, Cluster-Head Selection and Channel Allocation for IoTs in Smart Cities

Science.gov (United States)

Aslam, Saleem; Hasan, Najam Ul; Jang, Ju Wook; Lee, Kyung-Geun

2016-01-01

This paper highlights three critical aspects of the internet of things (IoTs), namely (1) energy efficiency, (2) energy balancing and (3) quality of service (QoS) and presents three novel schemes for addressing these aspects. For energy efficiency, a novel radio frequency (RF) energy-harvesting scheme is presented in which each IoT device is associated with the best possible RF source in order to maximize the overall energy that the IoT devices harvest. For energy balancing, the IoT devices in close proximity are clustered together and then an IoT device with the highest residual energy is selected as a cluster head (CH) on a rotational basis. Once the CH is selected, it assigns channels to the IoT devices to report their data using a novel integer linear program (ILP)-based channel allocation scheme by satisfying their desired QoS. To evaluate the presented schemes, exhaustive simulations are carried out by varying different parameters, including the number of IoT devices, the number of harvesting sources, the distance between RF sources and IoT devices and the primary user (PU) activity of different channels. The simulation results demonstrate that our proposed schemes perform better than the existing ones. PMID:27918424

Optimized Energy Harvesting, Cluster-Head Selection and Channel Allocation for IoTs in Smart Cities.

Science.gov (United States)

Aslam, Saleem; Hasan, Najam Ul; Jang, Ju Wook; Lee, Kyung-Geun

2016-12-02

This paper highlights three critical aspects of the internet of things (IoTs), namely (1) energy efficiency, (2) energy balancing and (3) quality of service (QoS) and presents three novel schemes for addressing these aspects. For energy efficiency, a novel radio frequency (RF) energy-harvesting scheme is presented in which each IoT device is associated with the best possible RF source in order to maximize the overall energy that the IoT devices harvest. For energy balancing, the IoT devices in close proximity are clustered together and then an IoT device with the highest residual energy is selected as a cluster head (CH) on a rotational basis. Once the CH is selected, it assigns channels to the IoT devices to report their data using a novel integer linear program (ILP)-based channel allocation scheme by satisfying their desired QoS. To evaluate the presented schemes, exhaustive simulations are carried out by varying different parameters, including the number of IoT devices, the number of harvesting sources, the distance between RF sources and IoT devices and the primary user (PU) activity of different channels. The simulation results demonstrate that our proposed schemes perform better than the existing ones.

Optimized Energy Harvesting, Cluster-Head Selection and Channel Allocation for IoTs in Smart Cities

Directory of Open Access Journals (Sweden)

Saleem Aslam

2016-12-01

Full Text Available This paper highlights three critical aspects of the internet of things (IoTs, namely (1 energy efficiency, (2 energy balancing and (3 quality of service (QoS and presents three novel schemes for addressing these aspects. For energy efficiency, a novel radio frequency (RF energy-harvesting scheme is presented in which each IoT device is associated with the best possible RF source in order to maximize the overall energy that the IoT devices harvest. For energy balancing, the IoT devices in close proximity are clustered together and then an IoT device with the highest residual energy is selected as a cluster head (CH on a rotational basis. Once the CH is selected, it assigns channels to the IoT devices to report their data using a novel integer linear program (ILP-based channel allocation scheme by satisfying their desired QoS. To evaluate the presented schemes, exhaustive simulations are carried out by varying different parameters, including the number of IoT devices, the number of harvesting sources, the distance between RF sources and IoT devices and the primary user (PU activity of different channels. The simulation results demonstrate that our proposed schemes perform better than the existing ones.

Real-Time Fault Detection Approach for Nonlinear Systems and its Asynchronous T-S Fuzzy Observer-Based Implementation.

Science.gov (United States)

Li, Linlin; Ding, Steven X; Qiu, Jianbin; Yang, Ying

2017-02-01

This paper is concerned with a real-time observer-based fault detection (FD) approach for a general type of nonlinear systems in the presence of external disturbances. To this end, in the first part of this paper, we deal with the definition and the design condition for an L ∞ / L 2 type of nonlinear observer-based FD systems. This analytical framework is fundamental for the development of real-time nonlinear FD systems with the aid of some well-established techniques. In the second part, we address the integrated design of the L ∞ / L 2 observer-based FD systems by applying Takagi-Sugeno (T-S) fuzzy dynamic modeling technique as the solution tool. This fuzzy observer-based FD approach is developed via piecewise Lyapunov functions, and can be applied to the case that the premise variables of the FD system is nonsynchronous with the premise variables of the fuzzy model of the plant. In the end, a case study on the laboratory setup of three-tank system is given to show the efficiency of the proposed results.

Risk of labor dystocia increases with maternal age irrespective of parity: a population-based register study.

Science.gov (United States)

Waldenström, Ulla; Ekéus, Cecilia

2017-09-01

Advanced maternal age is associated with labor dystocia (LD) in nulliparous women. This study investigates the age-related risk of LD in first, second and third births. All live singleton cephalic births at term (≥ 37 gestational weeks) recorded in the Swedish Medical Birth Register from 1999 to 2011, except elective cesarean sections and fourth births and more, in total 998 675 pregnancies, were included in the study. LD was defined by International Classification of Diseases, version 10 codes (O620, O621, O622, O629, O630, O631 and O639). In each parity group risks of LD at age 25-29 years, 30-34 years, 35-39 years and ≥ 40 years compared with age < 25 years were investigated by logistic regression analyses. Analyses were adjusted for year of delivery, education, country/region of birth, smoking in early pregnancy, maternal height, body mass index, week of gestation, fetal presentation and infant birthweight. Rates of LD were 22.5%, 6.1% and 4% in first, second and third births, respectively. Adjusted odd ratios (OR) for LD increased progressively from the youngest to the oldest age group, irrespective of parity. At age 35-39 years the adjusted OR (95% CI) was approximately doubled compared with age 25 and younger: 2.13 (2.06-2.20) in first birth; 2.05 (1.91-2.19) in second births; and 1.81 (1.49-2.21) in third births. Maternal age is an independent risk factor for LD in first, second and third births. Although age-related risks by parity are relatively similar, more nulliparous than parous women will be exposed to LD due to the higher rate. © 2017 Nordic Federation of Societies of Obstetrics and Gynecology.

Fabrication and characterization of PEDOT nanowires based on self-assembled peptide nanotube lithography

DEFF Research Database (Denmark)

Andersen, Karsten Brandt; Christiansen, Nikolaj Ormstrup; Castillo, Jaime

2013-01-01

In this article we demonstrate the use of self-assembled peptide nanotube structures as masking material in a rapid, mild and low cost fabrication of polymerized p-toluenesulfonate doped poly(3,4-ethylenedioxythiophene) (PEDOT:TsO) nanowire device. In this new fabrication approach the PEDOT:TsO n...

FACTORES QUE IMPACTAN EN LA SELECCIÓN E IMPLANTACIÓN DEL SISTEMA DE GESTIÓN ISO/TS 16949: CASO DEL SECTOR INDUSTRIAL DE AUTOPARTES DE LA CIUDAD DE BOGOTÁ

Directory of Open Access Journals (Sweden)

Nelson Yepes González

2014-01-01

Full Text Available Mediante la aplicación de la norma ISO/TS 16949, los fabricantes de automóviles ofrecen productos de calidad y mejoran los servicios ofrecidos a los clientes. Desde sus inicios de introducción, TS 16949 ha encontrado éxito dentro de la industria por la unificación y armonización con otras normas existentes. El presente artículo es un estudio empírico que se realizó mediante encuesta a 65 empresas de la industria autopartista en la ciudad de Bogotá (Colombia y que permitió determinar cómo se encuentra el estado de aplicación del estándar internacional, e identificar que los factores con incidencia que impactan en la aplicabilidad de la norma son la poca exigencia de los clientes, la falta de asesoría que reciben las empresas y el poco interés de los empresarios. El estudio pone de manifiesto la necesidad de realizar una mayor apropiación de la norma de calidad en las microempresas y pequeñas empresas con la finalidad de fortalecer su adopción para la mejora de la calidad de productos y servicios del sector automotor.

The LHC's suppliers come up trumps

CERN Multimedia

2006-01-01

Four of the LHC Project's most exceptional suppliers have just been honoured in the fifth Golden Hadron awards ceremony. For the first time, a CERN team was among the prize-winners. The CERN main workshop (Mechanical and Materials Engineering group, TS/MME) received the Golden Hadron Award at the prize-giving ceremony held at the Globe. From left to right, Saïd Atieh (TS/MME), Vincent Vuillemin (TS/MME group leader), Michel Caccioppoli (TS/MME), Lyn Evans (LHC Project Leader), Marc Polini (TS/MME-MS section leader), Jean-Luc Gayraud (Cegelec), Jean-Paul Bacher (TS/MME-AS section leader) and Paolo Ciriani (head of the TS Department). Flexible, responsive, committed... all fitting adjectives to describe the recipients of the fifth Golden Hadron awards. The prizes, designed to honour the LHC Project's best suppliers, were awarded to a total of four suppliers, including two that are involved in the final accelerator assembly work: proof, if it were needed, that the project has now entered its final phase. Drak...

Comparative study on effect of blending, thermal barrier coating ...

African Journals Online (AJOL)

The brake thermal efficiency, specific fuel consumption, carbon monoxide, unburned hydrocarbon and oxides of nitrogen emissions of both diesel and UOME and its blends were measured before and after coating and the results are compared. B20 fuelled biodiesel and PSZ coated engine provides almost comparable ...

Immersion calorimetry as a tool to evaluate the catalytic performance of titanosilicate materials in the epoxidation of cyclohexene.

Science.gov (United States)

Vernimmen, Jarian; Guidotti, Matteo; Silvestre-Albero, Joaquin; Jardim, Erika O; Mertens, Myrjam; Lebedev, Oleg I; Van Tendeloo, Gustaaf; Psaro, Rinaldo; Rodríguez-Reinoso, Francisco; Meynen, Vera; Cool, Pegie

2011-04-05

Different types of titanosilicates are synthesized, structurally characterized, and subsequently catalytically tested in the liquid-phase epoxidation of cyclohexene. The performance of three types of combined zeolitic/mesoporous materials is compared with that of widely studied Ti-grafted-MCM-41 molecular sieve and the TS-1 microporous titanosilicate. The catalytic test results are correlated with the structural characteristics of the different catalysts. Moreover, for the first time, immersion calorimetry with the same substrate molecule as in the catalytic test reaction is applied as an extra means to interpret the catalytic results. A good correlation between catalytic performance and immersion calorimetry results is found. This work points out that the combination of catalytic testing and immersion calorimetry can lead to important insights into the influence of the materials structural characteristics on catalysis. Moreover, the potential of using immersion calorimetry as a screening tool for catalysts in epoxidation reactions is shown.

Hyperinsulinemia correlates with low levels of plasma B-type natriuretic peptide in Japanese men irrespective of fat distribution

Directory of Open Access Journals (Sweden)

Nakatsuji Hideaki

2012-03-01

Full Text Available Abstract Background B-type natriuretic peptide (BNP, a member of the natriuretic peptide family, is a cardiac-derived secretory hormone with natriuretic, diuretic, and vasorelaxant activities. Intraabdominal fat accumulation is associated with atherosclerotic cardiovascular diseases and cardiac dysfunction. Circulating BNP levels are relatively low (within the normal limits in obesity and the metabolic syndrome. However, the relationship between plasma BNP levels and visceral fat accumulation in general population has not been reported. The present study analyzed the relationships between plasma BNP levels and various clinical variables, including insulin, visceral and subcutaneous fat area (VFA and SFA, respectively, in normal Japanese men. Methods The study (Victor-J study subjects were consecutive 500 Japanese male workers, who underwent a health checkup and were measured VFA and SFA by computed tomography. Results Age-adjusted simple linear regression analysis showed that log-BNP correlated positively with HDL-cholesterol, and negatively with VFA, log-immunoreactive insulin (IRI, log-triglyceride, and LDL-cholesterol, but not body mass index or SFA. Stepwise multiple regression analysis identified log-IRI and HDL-cholesterol as significant determinants of log-BNP. Subjects with IRI ≥5.5 μIU/mL had lower plasma BNP levels than those with IRI 2, visceral fat accumulation (VFA, cutoff value 100 cm2 and subcutaneous fat accumulation (SFA, cutoff value 128 cm2. Conclusions Our study showed that hyperinsulinemia correlated with low levels of plasma BNP in general men, irrespective of fat distribution. Trial registration UMIN 000004318.

Turner Syndrome: Genetic and Hormonal Factors Contributing to a Specific Learning Disability Profile

Science.gov (United States)

Rovet, Joanne

2004-01-01

Turner Syndrome (TS) is a genetic disorder affecting primarily females. It arises from a loss of X-chromosome material, most usually one of the two X chromosomes. Affected individuals have a number of distinguishing somatic features, including short stature and ovarian dysgenesis. Individuals with TS show a distinct neurocognitive profile…

Enhancing the thermal stability of natural rubber/recycled ethylene–propylene–diene rubber blends by means of introducing pre-vulcanised ethylene–propylene–diene rubber and electron beam irradiation

International Nuclear Information System (INIS)

Nabil, H.; Ismail, H.

2014-01-01

Highlights: • New route of processing was introduced to optimise the thermal stability of NR/R-EPDM blends. • Pre-vulcanised EPDM and EB irradiation were introduced into NR/R-EPDM blends. • Thermal stability is obviously enhanced by applying these two techniques. • Applying new route of processing methods is clearly successful to NR/R-EPDM blends. - Abstract: Most rubber materials are subjected to oxidation. The rate of oxidation depends on the type of rubber, processing method, and end-use conditions. The oxidation of rubber can result in the loss of physical properties, such as tensile strength, elongation, and flexibility. Hence, the service life is determined by oxidation stability. Thermal properties are relevant to the potential use of polymeric materials in many consumer oriented applications. Thermo-oxidative ageing and thermogravimetric analysis (TGA) have been proven to be successful techniques in determining the thermal stability of polymers and polymer blends. In this article, preparation of a series of natural rubber/recycled ethylene–propylene–diene rubber (NR/R-EPDM) blends is described. Processing of the blends, by means of introducing pre-vulcanised EPDM and electron beam (EB) irradiation, was carried out. Two thermal analysis methods, namely thermo-oxidative ageing and thermogravimetric analysis, were conducted. The results indicated that pre-vulcanising EPDM for 1.45 min (ts − 2) is sufficient to gain the optimum retained tensile and elongation at break. It was simultaneously observed that the introduction of pre-vulcanised EPDM increased decomposition temperature and activation energy by showing optimum values at a pre-vulcanising time of 3.45 min (ts). In the latter study, the retained properties increased after EB irradiation. The results can be verified by the thermal decomposition temperature and their activation energy. The obtained TG profiles and the calculated kinetic parameters indicated that introducing EB irradiation

Greenschist-Facies Pseudotachylytes and Gouge: a Microstructural Study of the Deformation Propagation at the Boundary Between Hp-Metabasite and Calcite Bearing Metasediments

Science.gov (United States)

Crispini, L.; Scambelluri, M.; Capponi, G.

2013-12-01

Recent friction experiments on calcite-bearing systems reproduce pseudotachylyte structures, that are diagnostic of dinamic calcite recrystallization related to seismic slip in the shallow crust. Here we provide the study of a pseudotachylyte (PT) bearing low angle oblique-slip fault. The fault is linked to the exhumation of Alpine HP-ophiolites and it is syn- to post-metamorphic with respect to retrograde greenschist facies metamorphism. The observed microstructures developed at the brittle-ductile transition and suggest that seismic and interseismic slip was enhanced by interaction with fluids. The fault zone is in-between high-pressure eclogite-facies metabasites (hangingwall) and calcite bearing metasediments (footwall). The mafic rocks largely consist of upper greenschist facies hornblende, albite, chlorite, epidote with relict eclogitic garnet, Na-pyroxene and rutile; metasediments correspond to calcschist and micaschist with quartz, phengite, zoisite, chlorite, calcite and relics of garnet. Key features of the oucrop are: the thickness and geometry of the PT and gouge; the multiple production of PT characterized by overprinting plastic and brittle deformation; the occurrence in footwall metasediments of mm-thick bands of finely recrystallized calcite coeval with PT development in the hangingwall. The damage zone is ca. 2 m-thick and is characterized by two black, ultra-finegrained straight and sharp Principal Slip Zones (PSZ) marked by PT. The damage zone shows a variety of fault rocks (cataclasite and ultracataclasite, gouge and PT) with multiple crosscutting relationships. Within the two main PSZ, PT occurs in 10-20 cm thick layer, in small scale injection veins and in microfractures. In the mafic hanging wall, the PT is recrystallized and does not preserve glass: it shows flow structures with subrounded, embayed and rebsorbed quartz in a fine grained matrix composed of isotropic albite + chlorite + quartz + epidote + titanite, suggesting recrystallization

Double-Layer Surface Modification of Polyamide Denture Base Material by Functionalized Sol-Gel Based Silica for Adhesion Improvement.

Science.gov (United States)

Hafezeqoran, Ali; Koodaryan, Roodabeh

2017-09-21

Limited surface treatments have been proposed to improve the bond strength between autopolymerizing resin and polyamide denture base materials. Still, the bond strength of autopolymerizing resins to nylon polymer is not strong enough to repair the fractured denture effectively. This study aimed to introduce a novel method to improve the adhesion of autopolymerizing resin to polyamide polymer by a double layer deposition of sol-gel silica and N-2-(aminoethyl)-3-aminopropyltrimethoxysilane (AE-APTMS). The silica sol was synthesized by acid-catalyzed hydrolysis of tetraethylorthosilicate (TEOS) as silica precursors. Polyamide specimens were dipped in TEOS-derived sol (TS group, n = 28), and exposed to ultraviolet (UV) light under O 2 flow for 30 minutes. UV-treated specimens were immersed in AE-APTMS solution and left for 24 hours at room temperature. The other specimens were either immersed in AE-APTMS solution (AP group, n = 28) or left untreated (NT group, n = 28). Surface characterization was investigated by fourier transform infrared spectroscopy (FTIR) and atomic force microscopy (AFM). Two autopolymerizing resins (subgroups G and T, n = 14) were bonded to the specimens, thermocycled, and then tested for shear bond strength with a universal testing machine. Data were analyzed with one-way ANOVA followed by Tukey's HSD (α = 0.05). FTIR spectra of treated surfaces confirmed the chemical modification and appearance of functional groups on the polymer. One-way ANOVA revealed significant differences in shear bond strength among the study groups. Tukey's HSD showed that TS T and TS G groups had significantly higher shear bond strength than control groups (p = 0.001 and p < 0.001, respectively). Moreover, bond strength values of AP T were statistically significant compared to controls (p = 0.017). Amino functionalized TEOS-derived silica coating is a simple and cost-effective method for improving the bond strength between the autopolymerizing resin and polyamide

Ground-State Distortion in N-Acyl-tert-butyl-carbamates (Boc) and N-Acyl-tosylamides (Ts): Twisted Amides of Relevance to Amide N-C Cross-Coupling.

Science.gov (United States)

Szostak, Roman; Shi, Shicheng; Meng, Guangrong; Lalancette, Roger; Szostak, Michal

2016-09-02

Amide N-C(O) bonds are generally unreactive in cross-coupling reactions employing low-valent transition metals due to nN → π*C═O resonance. Herein we demonstrate that N-acyl-tert-butyl-carbamates (Boc) and N-acyl-tosylamides (Ts), two classes of acyclic amides that have recently enabled the development of elusive amide bond N-C cross-coupling reactions with organometallic reagents, are intrinsically twisted around the N-C(O) axis. The data have important implications for the design of new amide cross-coupling reactions with the N-C(O) amide bond cleavage as a key step.

Comparison of distributed vortex receptivity coefficients at excitation of 3D TS-waves in presence and absence of surface waviness and pressure gradient

Science.gov (United States)

Borodulin, V. I.; Ivanov, A. V.; Kachanov, Y. S.; Mischenko, D. A.; Fedenkova, A. A.

2016-10-01

The paper is devoted to quantitative experimental investigation of effective mechanisms of excitation of 3D TS instability waves due to distributed boundary layer receptivity to free-stream vortices. Experiments carried out in a self-similar boundary layer with Hartree parameter βH = -0.115 and concentrated on studying two receptivity mechanisms connected with distributed scattering of 3D unsteady free-stream vortices both on the natural boundary layer nonuniformity (smooth surface) and on 2D surface nonuniformity (waviness). Obtained quantitative characteristics (distributed receptivity coefficients) are compared directly with those obtained in Blasius boundary layer. It is found that the adverse pressure gradient leads to reduction of efficiency of the vortex-roughness receptivity mechanism.

Planck 2015 results: XXVII. The second Planck catalogue of Sunyaev-Zeldovich sources

DEFF Research Database (Denmark)

Ade, P. A R; Aghanim, N.; Arnaud, M.

2016-01-01

We present the all-sky Planck catalogue of Sunyaev-Zeldovich (SZ) sources detected from the 29 month full-mission data. The catalogue (PSZ2) is the largest SZ-selected sample of galaxy clusters yet produced and the deepest systematic all-sky surveyof galaxy clusters. It contains 1653 detections, ...

Potensi Biogas dari Substrat Bio-Limbah Perhotelan

Directory of Open Access Journals (Sweden)

I Nyoman Suprapta Winaya

2015-07-01

Full Text Available Penelitian ini bertujuan untuk mengetahui potensi produksi biogas yang dihasilkan daripemanfaatan bio-limbah perhotelan seperti limbah dapur (kitchen dan limbah lumpur (sewagedengan penambahan inokolum kotoran hewan. Jumlah material kering (total solid, TS darilimbah hotel akan dikaji untuk diketahui pengaruhnya terhadap produksi biogas yang dihasilkan.Penelitian dilakukan secara eksperimen dengan variasi TS sebesar 3, 4, 5 gram ke dalamsebuah biodigester skala laboratorium kapasitas 1000ml. Pengukuran kinerja dari biodigesterdiamati selama 40 hari dan dilakukan pengkondisian pH pada digester kontrol. Pengujiankandungan gas metana dilakukan secara langsung menggunakan metode absorpsi CO2 Brigongas tester. Hasil penelitian menunjukkan bahwa dengan mengkondisikan pH pada rentang 6,8-7,5 merupakan kondisi ideal bagi bakteri metana sehingga mempengaruhi produksi biogas yangdihasilkan. Komposisi 5 gram TS sewage dengan pH dikondisikan menunjukkan volume spesifikbiogas paling tinggi. Sedangkan persentase gas metana yang dihasilkan tidak memiliki korelasilangsung terhadap komposisi material kering dan menunjukkan fenomena yang hampir seragamKata kunci : Limbah perhotelan, inokolum, biogas, total solid This study aims to determine biogas production using organic waste as raw material from hotelindustries such as kitchen waste and sewage sludge with the addition of inokolum. Total drymatter (total solid, TS of organic waste is studied to determine its effect on the biogas production.Experiments was conducted with a variation of TS of 3, 4, 5 grams into a biodigester laboratoryscale of 1000ml. Measurement of the performance of the biodigester was observed for 40 daysand the pH condition in the digester was controlled. Methane gas content was done directly usingBrigon CO2 gas tester. The results showed that the conditioned of pH 6.8 to 7.5 are found as theideal conditions for methane bacteria to produce of biogas. Composition of 5 grams TS sewagewith a

Sulcus reproduction with elastomeric impression materials: a new in vitro testing method.

Science.gov (United States)

Finger, Werner J; Kurokawa, Rie; Takahashi, Hidekazu; Komatsu, Masashi

2008-12-01

Aim of this study was to investigate the depth reproduction of differently wide sulci with elastomeric impression materials by single- and double-mix techniques using a tooth and sulcus model, simulating clinical conditions. Impressions with one vinyl polysiloxane (VPS; FLE), two polyethers (PE; IMP and P2), and one hybrid VPS/PE elastomer (FUS) were taken from a truncated steel cone with a circumferential 2 mm deep sulcus, 50, 100 or 200 microm wide. The "root surface" was in steel and the "periodontal tissue" in reversible hydrocolloid. Single-mix impressions were taken with light-body (L) or monophase (M) pastes, double-mix impressions with L as syringe and M or heavy-body (H) as tray materials (n=8). Sulcus reproduction was determined by 3D laser topography of impressions at eight locations, 45 degrees apart. Statistical data analysis by ANOVA and multiple comparison tests (pimpression materials only: FLE=IMP>FUS=P2. At 50 and 100 microm width, significant differences were found between materials (IMP>FUS=FLE>P2) and techniques (L+H=L+M>M>L). The sulcus model is considered useful for screening evaluation of elastomeric impression materials ability to reproduce narrow sulci. All tested materials and techniques reproduced 200 microm wide sulci to almost nominal depth. Irrespective of the impression technique used, IMP showed the best penetration ability in 50 and 100 microm sulci. Double-mix techniques are more suitable to reproduce narrow sulci than single-mix techniques.

Safety of transport of radioactive material. Contributed papers

Energy Technology Data Exchange (ETDEWEB)

NONE

2003-07-01

Radioactive material has been transported for decades within and between countries as the use of radioactive material to benefit mankind has expanded. The transport can involve many types of materials (radionuclides and radiation sources for applications in agriculture, energy production, industry, and medicine) and all modes of transport (road, rail, sea and waterways, and air). Among the organizations in the United Nations system, the International Atomic Energy Agency (IAEA) has the statutory function to establish or adopt standards of safety for protection of health against exposure to ionizing radiation. Within its statutory mandate and pursuant to this request, in 1961, the IAEA issued Regulations for the Safe Transport of Radioactive Material (the IAEA Transport Regulations). The Transport Regulations were periodically reviewed and, as appropriate, have been amended or revised. The latest version of the Transport Regulations was issued in 2000 by the IAEA as Publication TS-R-1 (ST-1, Revised). In addition, the IAEA is entrusted by its Statute to provide for the application of its standards at the request of States. The objective of the Conference is to foster the exchange of information on issues related to the safety of transport of radioactive material by providing an opportunity for representatives from sponsoring international organizations and their Member States and from other co-operating and participating organizations to discuss critical issues relating to the safety of transport of radioactive material by all modes and to formulate recommendations, as appropriate, regarding further international co-operation in this area. The following topics have been identified by the Technical Programme Committee as the subjects to be covered in the background briefing sessions: History and Status of the IAEA Transport Regulation Development; Experience in adoption of the IAEA Transport Regulations at the international level; Implementation of the IAEA Transport

Modelo de atención al cliente para Mundialo CÍA.LTDA. Distribuidor autorizado de claro en Santo Domingo, basado en la norma ISO/TS 10004: 2010

OpenAIRE

Toapanta Pauta, Verónica Andrea

2015-01-01

El presente estudio fundamenta la investigación para establecer “El modelo de atención al cliente para MUNDIALO CÍA. LTDA., basado en la norma ISO/TS 10004:2010”, durante su desarrollo se realizó un diagnóstico situacional, respecto a la atención al cliente, así como el levantamiento del sus principales procesos, con la ayuda de herramientas de calidad tales como el Diagrama Causa-Efecto y Pareto. La idea central es desarrollar sugerencias para el cumplimiento de las siguientes etapas: Pla...

Characterization of susceptibility of metallic materials to environmentally assisted cracking. Final report

International Nuclear Information System (INIS)

Dietzel, W.

1999-01-01

The stress corrosion cracking (SCC) of three different material/environment combinations was investigated in an inter-laboratory test programme using five different SCC test methods, with special emphasis laid on a new rising displacement test method which was to be further developed in the course of this project. The degree of reliability that could be obtained with each of the test methods and their usability were assessed. In all cases the experimental data characterising the occurrence of SCC show considerable scatter, irrespective of the test method. Based on the experience gained in the test programme, a draft for a new part of the ISO standard 7539 was elaborated and has meanwhile attained the status of an ISO Draft International Standard (ISO/DIS). (orig.) [de

Optical properties and light irradiance of monolithic zirconia at variable thicknesses.

Science.gov (United States)

Sulaiman, Taiseer A; Abdulmajeed, Aous A; Donovan, Terrence E; Ritter, André V; Vallittu, Pekka K; Närhi, Timo O; Lassila, Lippo V

2015-10-01

The aims of this study were to: (1) estimate the effect of polishing on the surface gloss of monolithic zirconia, (2) measure and compare the translucency of monolithic zirconia at variable thicknesses, and (3) determine the effect of zirconia thickness on irradiance and total irradiant energy. Four monolithic partially stabilized zirconia (PSZ) brands; Prettau® (PRT, Zirkonzahn), Bruxzir® (BRX, Glidewell), Zenostar® (ZEN, Wieland), Katana® (KAT, Noritake), and one fully stabilized zirconia (FSZ); Prettau Anterior® (PRTA, Zirkonzahn) were used to fabricate specimens (n=5/subgroup) with different thicknesses (0.5, 0.7, 1.0, 1.2, 1.5, and 2.0mm). Zirconia core material ICE® Zircon (ICE, Zirkonzahn) was used as a control. Surface gloss and translucency were evaluated using a reflection spectrophotometer. Irradiance and total irradiant energy transmitted through each specimen was quantified using MARC® Resin Calibrator. All specimens were then subjected to a standardized polishing method and the surface gloss, translucency, irradiance, and total irradiant energy measurements were repeated. Statistical analysis was performed using two-way ANOVA and post-hoc Tukey's tests (pgloss was significantly affected by polishing (p<0.05), regardless of brand and thickness. Translucency values ranged from 5.65 to 20.40 before polishing and 5.10 to 19.95 after polishing. The ranking from least to highest translucent (after polish) was: BRX=ICE=PRTPSZ. Copyright © 2015 Academy of Dental Materials

High-beta characteristics of first and second-stable spherical tokamaks in reconnection heating experiments of TS-3

International Nuclear Information System (INIS)

Ono, Y.

2002-01-01

Novel formations of ultra-high-beta Spherical Tokamak (ST) have been developed in the TS-3 device using high power heating of merging/ reconnection. In Type-A merging, two STs were merged together to build up the plasma beta. In Type-B merging, an oblate FRC was initially formed by merging of two spheromaks with opposing toroidal field B t and was transformed into an ultra-high-beta ST by applying external B t . Ballooning stability analyses confirmed formations of the first-stable STs by Type- A merging and the second-stable STs by Type-B merging and also the unstable STs by both mergings, revealing the ballooning stability window consistent with measured high-n instabilities. We made (1) those model analyses of the produced STs for the first time using the BALLOO stability code, revealing that hollowness/ broadness of current/pressure profiles widen significantly the window to the second-stable regime. This paper also addresses (2) normalized betas of the second-stable STs as large as 6-17 for comparison with the Troyon scaling and (3) a promising scaling of the reconnection heating energy. (author)

Efficient Security Mechanisms for the Border Gateway Routing Protocol

Science.gov (United States)

1997-08-22

Finding Algorithm for Loop- Free Routing. IEEE/ACM Transactions on Networking, 5(1):148{160, Feb. 1997. [7] International Standards Organization. ISO/IEC...Jersey 07974, Feb. 1985. ftp://netlib.att.com/netlib/att/cs/ cstr /117.ps.Z. [16] S. L. Murphy. Presentation in Panel on \\Security Architecture for the

Effects of short term and long term soil warming on ecosystem phenology of a sub-arctic grassland: an NDVI-based approach

Science.gov (United States)

Leblans, Niki; Sigurdsson, Bjarni D.; Janssens, Ivan A.

2014-05-01

% greening was advanced by 23 days at +5°C and by 32 days at +10°C Ts. However, no difference in the date of maximum greening or in the onset of senescence occurred. In contrast, in the long-term warmed grassland, the start of the growing season was not affected by Ts and the 50% greening point occurred only 10 days earlier at +5°C and 15 days earlier at +10°C Ts. However, the timing of maximum greening was advanced by 19 days at +5°C and even by 32 days at +10°C Ts. Again, the onset of senescence did not change with Ts. Significant Ts effects on ecosystem phenology of subarctic grasslands only occurred at warming of 5°C or higher. This study also demonstrates that short-term Ts effects on ecosystem phenology are not necessarily good predictors for long-term changes in sub-arctic grasslands. In the short-term (5 years warming), soil warming induced an early onset of the growing season, which was later compensated by faster greening on colder soils, so that maximum greenness was reached simultaneously irrespective of Ts. In contrast, the long-term Ts warming did not induce earlier onset of the growing season, but it led to faster greening on warm soils, which again led to an advance in timing of maximum greenness. This difference between short- and long-term responses in phenology might be caused by either phenotypic plasticity (acclimation) or by a genetic selection (evolution) of the grass populations where the warming has been ongoing for centuries. Such processes are at present not included in modelling predictions of climate change responses of natural ecosystems, but may offer important negative feedback mechanisms to warming which will reduce its effects.

Utilization of a ts-sacB selection system for the generation of a Mycobacterium avium serovar-8 specific glycopeptidolipid allelic exchange mutant

Science.gov (United States)

Irani, Vida R; Lee, Sun-Hwa; Eckstein, Torsten M; Inamine, Julia M; Belisle, John T; Maslow, Joel N

2004-01-01

Background Mycobacterium avium are ubiquitous environmental organisms and a cause of disseminated infection in patients with end-stage AIDS. The glycopeptidolipids (GPL) of M. avium are proposed to participate in the pathogenesis of this organism, however, establishment of a clear role for GPL in disease production has been limited by the inability to genetically manipulate M. avium. Methods To be able to study the role of the GPL in M. avium pathogenesis, a ts-sacB selection system, not previously used in M. avium, was employed as a means to achieve homologous recombination for the rhamnosyltransferase (rtfA) gene of a pathogenic serovar 8 strain of M. avium to prevent addition of serovar-specific sugars to rhamnose of the fatty acyl-peptide backbone of GPL. The genotype of the resultant rtfA mutant was confirmed by polymerase chain reaction and southern hybridization. Disruption in the proximal sugar of the haptenic oligosaccharide resulted in the loss of serovar specific GPL with no change in the pattern of non-serovar specific GPL moieties as shown by thin layer chromatography and gas chromatography/mass spectrometry. Complementation of wild type (wt) rtfA in trans through an integrative plasmid restored serovar-8 specific GPL expression identical to wt serovar 8 parent strain. Results In this study, we affirm our results that rtfA encodes an enzyme responsible for the transfer of Rha to 6d-Tal and provide evidence of a second allelic exchange mutagenesis system suitable for M. avium. Conclusion We report the second allelic exchange system for M. avium utilizing ts-sacB as double-negative and xylE as positive counter-selection markers, respectively. This system of allelic exchange would be especially useful for M. avium strains that demonstrate significant isoniazid (INH) resistance despite transformation with katG. Through the construction of mutants in GPL or other mycobacterial components, their roles in M. avium pathogenesis, biosynthesis, or drug

Utilization of a ts-sacB selection system for the generation of a Mycobacterium avium serovar-8 specific glycopeptidolipid allelic exchange mutant

Directory of Open Access Journals (Sweden)

Belisle John T

2004-09-01

Full Text Available Abstract Background Mycobacterium avium are ubiquitous environmental organisms and a cause of disseminated infection in patients with end-stage AIDS. The glycopeptidolipids (GPL of M. avium are proposed to participate in the pathogenesis of this organism, however, establishment of a clear role for GPL in disease production has been limited by the inability to genetically manipulate M. avium. Methods To be able to study the role of the GPL in M. avium pathogenesis, a ts-sacB selection system, not previously used in M. avium, was employed as a means to achieve homologous recombination for the rhamnosyltransferase (rtfA gene of a pathogenic serovar 8 strain of M. avium to prevent addition of serovar-specific sugars to rhamnose of the fatty acyl-peptide backbone of GPL. The genotype of the resultant rtfA mutant was confirmed by polymerase chain reaction and southern hybridization. Disruption in the proximal sugar of the haptenic oligosaccharide resulted in the loss of serovar specific GPL with no change in the pattern of non-serovar specific GPL moieties as shown by thin layer chromatography and gas chromatography/mass spectrometry. Complementation of wild type (wt rtfA in trans through an integrative plasmid restored serovar-8 specific GPL expression identical to wt serovar 8 parent strain. Results In this study, we affirm our results that rtfA encodes an enzyme responsible for the transfer of Rha to 6d-Tal and provide evidence of a second allelic exchange mutagenesis system suitable for M. avium. Conclusion We report the second allelic exchange system for M. avium utilizing ts-sacB as double-negative and xylE as positive counter-selection markers, respectively. This system of allelic exchange would be especially useful for M. avium strains that demonstrate significant isoniazid (INH resistance despite transformation with katG. Through the construction of mutants in GPL or other mycobacterial components, their roles in M. avium pathogenesis

Spatially resolved Raman spectroscopy study of transformed zones in magnesia-partially-stabilized zirconia

International Nuclear Information System (INIS)

Davskardt, R.H.; Veirs, D.K.; Ritchie, R.O.

1989-01-01

Raman vibrational spectroscopy provides an effective phase characterization technique in materials systems containing particle dispersions of the tetragonal and monoclinic polymorphs of zirconia, each of which yields a unique Raman spectrum. An investigation is reported to assess a novel, spatially resolved Raman spectroscopy system in the study of transformed zones surrounding cracks in partially stabilized MgO-ZrO 2 (PSZ). The experimental arrangement uses an imaging (two-dimensional) photomultiplier tube to produce a one-dimensional Raman profile of phase compositions along a slitlike laser beam without translation of either the sample or the laser beam and without scanning the spectrometer. Results from phase characterization studies of the size, frontal morphology, and extent of transformation of transformation zones surrounding cracks produced under monotonic and cyclic loading conditions are presented

Quantitative Elastography for Cervical Stiffness Assessment during Pregnancy

Directory of Open Access Journals (Sweden)

A. Fruscalzo

2014-01-01

Full Text Available Aim. Feasibility and reliability of tissue Doppler imaging-(TDI- based elastography for cervical quantitative stiffness assessment during all three trimesters of pregnancy were evaluated. Materials and Methods. Prospective case-control study including seventy-four patients collected between the 12th and 42nd weeks of gestation. The tissue strain (TS was measured by two independent operators as natural strain. Intra- and interoperator intraclass correlation coefficient (ICC agreements were evaluated. Results. TS measurement was always feasible and exhibited a high performance in terms of reliability (intraoperator ICC-agreement = 0.93; interoperator ICC agreement = 0.89 and 0.93 for a single measurement and for the average of two measurements, resp.. Cervical TS showed also a significant correlation with gestational age, cervical length, and parity. Conclusions. TS measurement during pregnancy demonstrated high feasibility and reliability. Furthermore, TS significantly correlated with gestational age, cervical length, and parity.

Design of robust reliable control for T-S fuzzy Markovian jumping delayed neutral type neural networks with probabilistic actuator faults and leakage delays: An event-triggered communication scheme.

Science.gov (United States)

Syed Ali, M; Vadivel, R; Saravanakumar, R

2018-06-01

This study examines the problem of robust reliable control for Takagi-Sugeno (T-S) fuzzy Markovian jumping delayed neural networks with probabilistic actuator faults and leakage terms. An event-triggered communication scheme. First, the randomly occurring actuator faults and their failures rates are governed by two sets of unrelated random variables satisfying certain probabilistic failures of every actuator, new type of distribution based event triggered fault model is proposed, which utilize the effect of transmission delay. Second, Takagi-Sugeno (T-S) fuzzy model is adopted for the neural networks and the randomness of actuators failures is modeled in a Markov jump model framework. Third, to guarantee the considered closed-loop system is exponential mean square stable with a prescribed reliable control performance, a Markov jump event-triggered scheme is designed in this paper, which is the main purpose of our study. Fourth, by constructing appropriate Lyapunov-Krasovskii functional, employing Newton-Leibniz formulation and integral inequalities, several delay-dependent criteria for the solvability of the addressed problem are derived. The obtained stability criteria are stated in terms of linear matrix inequalities (LMIs), which can be checked numerically using the effective LMI toolbox in MATLAB. Finally, numerical examples are given to illustrate the effectiveness and reduced conservatism of the proposed results over the existing ones, among them one example was supported by real-life application of the benchmark problem. Copyright © 2018 ISA. Published by Elsevier Ltd. All rights reserved.

Potential of AlN nanostructures as hydrogen storage materials.

Science.gov (United States)

Wang, Qian; Sun, Qiang; Jena, Puru; Kawazoe, Yoshiyuki

2009-03-24

The capability of AlN nanostructures (nanocages, nanocones, nanotubes, and nanowires) to store hydrogen has been studied using gradient-corrected density functional theory. In contrast to bulk AlN, which has the wurtzite structure and four-fold coordination, the Al sites in AlN nanostructures are unsaturated and have two- and three-fold coordination. Each Al atom is capable of binding one H(2) molecule in quasi-molecular form, leading to 4.7 wt % hydrogen, irrespective of the topology of the nanostructures. With the exception of AlN nanotubes, energetics does not support the adsorption of additional hydrogen. The binding energies of hydrogen to these unsaturated metal sites lie in the range of 0.1-0.2 eV/H(2) and are ideal for applications under ambient thermodynamic conditions. Furthermore, these materials do not suffer from the clustering problem that often plagues metal-coated carbon nanostructures.

Proyecto RAILCEN: estudio de la evolución de un incendio en vehículo ferroviario provocado por materiales de interiorismo de acuerdo a CEN / TS 45545-2

OpenAIRE

López, Marta; Martínez, Izaskun; Lacasta Palacio, Ana María; Nylander, Pasi; Gallego, Emiliano

2009-01-01

La reciente aprobación de la especificación técnica CEN/TS 45545, es considerada un gran avance en lo que a requisitos de seguridad en ferrocarriles se refiere, debido a la importante necesidad actual de unificación de exigencias frente a incendio originado por la cada vez mayor red de tráfico ferroviario entre diferentes países de la UE. Así, a nivel nacional, dos empresas de importante participación en el sector como son FAINSA S.A. (fabricante de asientos) y Patentes TALGO S...

Geochemical study of the insoluble organic material (kerogen) in the Oklo uranium ore and the associated Francevillian schists

International Nuclear Information System (INIS)

Vandenbroucke, M.; Rouzaud, J.N.; Oberlin, A.

1978-01-01

The purpose of this study was to describe the organic material associated with uranium ore and ore transformations undergone by it, in terms of the following problems: (1) In the natural reactor zones, evolution of the organic material in the core and as a function of the distance away from it; (2) Comparison of organic materials from a rich and a poor ore; (3) Intercomparison of organic materials in the dispersed and concentrated state; (4) Comparison of organic materials in the uranium ore zones and in the adjacent non-mineralized Francevillian. The organic material from the reactor core could not be isolated by the normal techniques of treatment with acid. It is found in other cases that the organic material is oxidized in the uranium-bearing sediments and that the nearer to the reaction zone, the greater the oxidation, irrespective of the state of dispersion of the organic material in the rock. The uranium content does not affect this phenomenon, which is attributed to the action of the water raised to a high temperature in the vicinity of the reaction zones. On the basis of the present distribution of organic material and uranium the authors suggest a pattern for the formation of the deposit that would take into account localization of the ore in the sandstones and the part played by organic material in the accumulation process. (author)

Gram-positive and gram-negative bacteria induce different patterns of cytokine production in human mononuclear cells irrespective of taxonomic relatedness.

Science.gov (United States)

Skovbjerg, Susann; Martner, Anna; Hynsjö, Lars; Hessle, Christina; Olsen, Ingar; Dewhirst, Floyd E; Tham, Wilhelm; Wold, Agnes E

2010-01-01

Upon bacterial stimulation, tissue macrophages produce a variety of cytokines that orchestrate the immune response that clears the infection. We have shown that Gram-positives induce higher levels of interleukin-12 (IL-12), interferon-gamma (IFN-gamma), and tumor necrosis factor (TNF) from human peripheral blood mononuclear cells (PBMCs) than do Gram-negatives, which instead induce more of IL-6, IL-8, and IL-10. Here, we study whether these patterns follows or crosses taxonomic borders. PBMCs from blood donors were incubated with UV-inactivated bacteria representing 37 species from five phyla. IL-12, TNF, IL-1beta, IL-6, IL-8, and IL-10 were measured in the supernatants after 24 h and IFN-gamma after 5 days. Irrespective of phylogenetic position, Gram-positive bacteria induced much more IL-12 (nine times more on average) and IFN-gamma (seven times), more TNF (three times), and slightly more IL-1beta (1.5 times) than did Gram-negatives, which instead induced more IL-6 (1.5 times), IL-8 (1.9 times), and IL-10 (3.3 times) than did Gram-positives. A notable exception was the Gram-positive Listeria monocytogenes, which induced very little IL-12, IFN-gamma, and TNF. The results confirm the fundamental difference in innate immune responses to Gram-positive and Gram-negative bacteria, which crosses taxonomic borders and probably reflects differences in cell wall structure.

Freeze drying synthesis of LiNi0.5Mn0.5O2 cathode materials

International Nuclear Information System (INIS)

Shlyakhtin, O.A.; Yoon, Young Soo; Choi, Sun Hee; Oh, Young-Jei

2004-01-01

The influence of several processing conditions on the phase formation and electrochemical performance of LiNi 0.5 Mn 0.5 O 2 powders, obtained by freeze drying method, is studied. Thermal processing in pellets at maximum heating rate promotes better crystallographic ordering of hexagonal LiNi 0.5 Mn 0.5 O 2 and maximum capacity values irrespectively of chemical composition of the precursor. Instead, intense mechanical processing of precursors exerts considerable negative effect on the electrochemical performance. Cathode materials containing superstoichiometric amount of lithium (Li 1.3 Mn 0.5 Ni 0.5 O 2+δ ) demonstrate reversible capacity values up to 190 mAh/g between 2.5 and 4.6 V

Forma da correlação T-S de massas de água das regiões costeira e oceânica entre o Cabo de São Tomé (RJ e a Ilha de São Sebastião (SP, Brasil T-S correlation in water musses of the coastal and oceanic regions between Cabo de São Tomé (RJ and São Sebastião Island (SP, Brazil

Directory of Open Access Journals (Sweden)

Luiz Bruner de Miranda

1985-01-01

Full Text Available As variações na estrutura e em propriedades de massas de água da plataforma continental e das de água oceânica adjacente são estudadas com base em expressões analíticas das curvas T-S, As medições das variáveis oceanográficas foram feitas por métodos clássicos numa rede de estações hidrografiacas, as quais foram amostradas em cinco intervalos de tempo (5-10 dias cada um, entre os meses de janeiro de 1970 e fevereiro de 1971. A revisão da classificação das massas de água usada sob condições regionais confirma que as Massas de Água Subtropical Profunda (ASTP, Subtropical (AST e Centrando Atlântico Sul (ACAS, são designações diferentes de uma mesma massa de água. A ultima nomenclatura, Água Central do Atlântico Sul (ACAS, é sugerida para indicar a massa de água com índice termohalino (20,0ºC; 36,36 ‰ , a qual e observada sob a Massa de Água Tropical. Esse valor de salinidade e um pouco maior do que o índice termohalino modificado da ACAS (36,20 ‰ e pode ser usado com vantagem nos cálculos volumétricos na área. As expressões polinomiais da curva T-S, cujos coeficientes foram determinados pelo método dos mínimos quadrados, foram usadas em aplicações práticas. Nessas aplicações, foram desenvolvidos métodos alternativos para a determinação da derivada termohalina e da razao de densidade constante (Rρ = αdT/βdS.Characteristics of the structure and sea water properties on the continental shelf and waters adjacent to the continental slope, were studied based on the temperature-salinity (T-S relationships. The water sampling was carried out with standard methods in a network of hydrographie stations worked in five-time intervals (5-10 days, from January 1970 through February 1971. The classification review of the water masses used under regional conditions confirm that the Subtropical-Deep (STDW, Subtropical (STW and South Atlantic Central (SACW Water Masses are different nomenclature for the same

Production of dimethylsulphide during the seasonal anoxia off Goa

Digital Repository Service at National Institute of Oceanography (India)

Shenoy, D.M.; Sujith, K.B.; Gauns, M.; Patil, S.; Sarkar, Amit; Naik, H.; Narvekar, P.V.; Naqvi, S.W.A.

to better understand the formation of anoxia and its influence on DMS production. Materials and methods: A 3-day observation was carried out at station G5 (Figure 1), which is part of the Candolim times series transect, known in short as CaTS. The quasi...-time series transect (CaTS) was established in 1997 and is located off the coast of Candolim, a coastal village in North Goa. The CaTS-G5 station, which has a depth of approximately 28 m, was occupied from 1340 hours on 25 th September’09 until 1824 hours...

Thermodynamic Property Surfaces for Adsorption of R507A, R134a, and n -Butane on Pitch-Based Carbonaceous Porous Materials

KAUST Repository

Chakraborty, Anutosh

2010-10-01

The thermodynamic property surfaces of R507A, R134a, and n-butane on pitch-based carbonaceous porous material (Maxsorb III) are developed from rigorous classical thermodynamics and experimentally measured adsorption isotherm data. These property fields enable us to compute the entropy, enthalpy, internal energy, and heat of adsorption as a function of pressure, temperature, and the amount of adsorbate. The entropy and enthalpy maps are necessary for the analysis of adsorption cooling cycle and gas storage. We have shown here that it is possible to plot an adsorption cooling cycle on the temperature-entropy (T-s) and enthalpy-uptake (h-x) maps. Copyright © Taylor and Francis Group, LLC 2010.

Thermodynamic Property Surfaces for Adsorption of R507A, R134a, and n -Butane on Pitch-Based Carbonaceous Porous Materials

KAUST Repository

Chakraborty, Anutosh; Saha, Bidyut Baran; Ng, Kim Choon; El-Sharkawy, Ibrahim I.; Koyama, Shigeru

2010-01-01

The thermodynamic property surfaces of R507A, R134a, and n-butane on pitch-based carbonaceous porous material (Maxsorb III) are developed from rigorous classical thermodynamics and experimentally measured adsorption isotherm data. These property fields enable us to compute the entropy, enthalpy, internal energy, and heat of adsorption as a function of pressure, temperature, and the amount of adsorbate. The entropy and enthalpy maps are necessary for the analysis of adsorption cooling cycle and gas storage. We have shown here that it is possible to plot an adsorption cooling cycle on the temperature-entropy (T-s) and enthalpy-uptake (h-x) maps. Copyright © Taylor and Francis Group, LLC 2010.

Planck 2013 results. XX. Cosmology from Sunyaev-Zeldovich cluster counts

CERN Document Server

Ade, P.A.R.; Armitage-Caplan, C.; Arnaud, M.; Ashdown, M.; Atrio-Barandela, F.; Aumont, J.; Baccigalupi, C.; Banday, A.J.; Barreiro, R.B.; Barrena, R.; Bartlett, J.G.; Battaner, E.; Battye, R.; Benabed, K.; Benoit, A.; Benoit-Levy, A.; Bernard, J.P.; Bersanelli, M.; Bielewicz, P.; Bikmaev, I.; Blanchard, A.; Bobin, J.; Bock, J.J.; Bohringer, H.; Bonaldi, A.; Bond, J.R.; Borrill, J.; Bouchet, F.R.; Bourdin, H.; Bridges, M.; Brown, M.L.; Bucher, M.; Burenin, R.; Burigana, C.; Butler, R.C.; Cardoso, J.F.; Carvalho, P.; Catalano, A.; Challinor, A.; Chamballu, A.; Chary, R.R.; Chiang, L.Y.; Chiang, H.C.; Chon, G.; Christensen, P.R.; Church, S.; Clements, D.L.; Colombi, S.; Colombo, L.P.L.; Couchot, F.; Coulais, A.; Crill, B.P.; Curto, A.; Cuttaia, F.; Da Silva, A.; Dahle, H.; Danese, L.; Davies, R.D.; Davis, R.J.; de Bernardis, P.; de Rosa, A.; de Zotti, G.; Delabrouille, J.; Delouis, J.M.; Democles, J.; Desert, F.X.; Dickinson, C.; Diego, J.M.; Dolag, K.; Dole, H.; Donzelli, S.; Dore, O.; Douspis, M.; Dupac, X.; Efstathiou, G.; Ensslin, T.A.; Eriksen, H.K.; Finelli, F.; Flores-Cacho, I.; Forni, O.; Frailis, M.; Franceschi, E.; Fromenteau, S.; Galeotta, S.; Ganga, K.; Genova-Santos, R.T.; Giard, M.; Giardino, G.; Giraud-Heraud, Y.; Gonzalez-Nuevo, J.; Gorski, K.M.; Gratton, S.; Gregorio, A.; Gruppuso, A.; Hansen, F.K.; Hanson, D.; Harrison, D.; Henrot-Versille, S.; Hernandez-Monteagudo, C.; Herranz, D.; Hildebrandt, S.R.; Hivon, E.; Hobson, M.; Holmes, W.A.; Hornstrup, A.; Hovest, W.; Huffenberger, K.M.; Hurier, G.; Jaffe, T.R.; Jaffe, A.H.; Jones, W.C.; Juvela, M.; Keihanen, E.; Keskitalo, R.; Khamitov, I.; Kisner, T.S.; Kneissl, R.; Knoche, J.; Knox, L.; Kunz, M.; Kurki-Suonio, H.; Lagache, G.; Lahteenmaki, A.; Lamarre, J.M.; Lasenby, A.; Laureijs, R.J.; Lawrence, C.R.; Leahy, J.P.; Leonardi, R.; Leon-Tavares, J.; Lesgourgues, J.; Liddle, A.; Liguori, M.; Lilje, P.B.; Linden-Vornle, M.; Lopez-Caniego, M.; Lubin, P.M.; Macias-Perez, J.F.; Maffei, B.; Maino, D.; Mandolesi, N.; Marcos-Caballero, A.; Maris, M.; Marshall, D.J.; Martin, P.G.; Martinez-Gonzalez, E.; Masi, S.; Matarrese, S.; Matthai, F.; Mazzotta, P.; Meinhold, P.R.; Melchiorri, A.; Melin, J.B.; Mendes, L.; Mennella, A.; Migliaccio, M.; Mitra, S.; Miville-Deschenes, M.A.; Moneti, A.; Montier, L.; Morgante, G.; Mortlock, D.; Moss, A.; Munshi, D.; Naselsky, P.; Nati, F.; Natoli, P.; Netterfield, C.B.; Norgaard-Nielsen, H.U.; Noviello, F.; Novikov, D.; Novikov, I.; Osborne, S.; Oxborrow, C.A.; Paci, F.; Pagano, L.; Pajot, F.; Paoletti, D.; Partridge, B.; Pasian, F.; Patanchon, G.; Perdereau, O.; Perotto, L.; Perrotta, F.; Piacentini, F.; Piat, M.; Pierpaoli, E.; Pietrobon, D.; Plaszczynski, S.; Pointecouteau, E.; Polenta, G.; Ponthieu, N.; Popa, L.; Poutanen, T.; Pratt, G.W.; Prezeau, G.; Prunet, S.; Puget, J.L.; Rachen, J.P.; Rebolo, R.; Reinecke, M.; Remazeilles, M.; Renault, C.; Ricciardi, S.; Riller, T.; Ristorcelli, I.; Rocha, G.; Roman, M.; Rosset, C.; Roudier, G.; Rowan-Robinson, M.; Rubino-Martin, J.A.; Rusholme, B.; Sandri, M.; Santos, D.; Savini, G.; Scott, D.; Seiffert, M.D.; Shellard, E.P.S.; Spencer, L.D.; Starck, J.L.; Stolyarov, V.; Stompor, R.; Sudiwala, R.; Sunyaev, R.; Sureau, F.; Sutton, D.; Suur-Uski, A.S.; Sygnet, J.F.; Tauber, J.A.; Tavagnacco, D.; Terenzi, L.; Toffolatti, L.; Tomasi, M.; Tristram, M.; Tucci, M.; Tuovinen, J.; Turler, M.; Umana, G.; Valenziano, L.; Valiviita, J.; Van Tent, B.; Vielva, P.; Villa, F.; Vittorio, N.; Wade, L.A.; Wandelt, B.D.; Weller, J.; White, M.; White, S.D.M.; Yvon, D.; Zacchei, A.; Zonca, A.

2014-01-01

We present constraints on cosmological parameters using number counts as a function of redshift for a sub-sample of 189 galaxy clusters from the Planck SZ (PSZ) catalogue. The PSZ is selected through the signature of the Sunyaev--Zeldovich (SZ) effect, and the sub-sample used here has a signal-to-noise threshold of seven, with each object confirmed as a cluster and all but one with a redshift estimate. We discuss the completeness of the sample and our construction of a likelihood analysis. Using a relation between mass $M$ and SZ signal $Y$ calibrated to X-ray measurements, we derive constraints on the power spectrum amplitude $\\sigma_8$ and matter density parameter $\\Omega_{\\mathrm{m}}$ in a flat $\\Lambda$CDM model. We test the robustness of our estimates and find that possible biases in the $Y$--$M$ relation and the halo mass function are larger than the statistical uncertainties from the cluster sample. Assuming the X-ray determined mass to be biased low relative to the true mass by between zero and 30%, m...

Rat bone marrow progenitor cells transduced in situ by rSV40 vectors differentiate into multiple central nervous system cell lineages.

Science.gov (United States)

Louboutin, Jean-Pierre; Liu, Bianling; Reyes, Beverly A S; Van Bockstaele, Elisabeth J; Strayer, David S

2006-12-01

Using bone marrow-directed gene transfer, we tested whether bone marrow-derived cells may function as progenitors of central nervous system (CNS) cells in adult animals. SV40-derived gene delivery vectors were injected directly into femoral bone marrow, and we examined transgene expression in blood and brain for 0-16 months thereafter by immunostaining for FLAG epitope marker. An average of 5% of peripheral blood cells and 25% of femoral marrow cells were FLAG(+) throughout the study. CNS FLAG-expressing cells were mainly detected in the dentate gyrus (DG) and periventricular subependymal zone (PSZ). Although absent before 1 month and rare at 4 months, DG and PSZ FLAG(+) cells were abundant 16 months after bone marrow injection. Approximately 5% of DG cells expressed FLAG, including neurons (48.6%) and microglia (49.7%), and occasional astrocytes (1.6%), as determined by double immunostaining for FLAG and lineage markers. These data suggest that one or more populations of cells resident within adult bone marrow can migrate to the brain and differentiate into CNS-specific cells.

Effects of a Technology Supported Project Based Learning (TS-PBL Approach on the Success of a Mobile Application Development Course and the Students’ Opinions

Directory of Open Access Journals (Sweden)

Fezile Ozdamli

2017-05-01

Full Text Available Similar to traditional desktop software development processes, teamwork is a necessity in the mobile application development process. Thus, the aim of this study is to examine the effects of the technology supported project-based learning approach in mobile application development courses on the academic achievement of students and to clarify the engineering students’ opinions. A total of 130 engineering students from the Department taking mobile application development courses were the participants of this study. The lessons progressed in one group in the form of technology supported project-based learning steps, while in the other group, they were conducted using traditional methods. Based on the results, the practical implementation of a mobile application with a TS-PBL approach in engineering students’ education will be discussed.

The Sense of Agency Is More Sensitive to Manipulations of Outcome than Movement-Related Feedback Irrespective of Sensory Modality.

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Nicole David

Full Text Available The sense of agency describes the ability to experience oneself as the agent of one's own actions. Previous studies of the sense of agency manipulated the predicted sensory feedback related either to movement execution or to the movement's outcome, for example by delaying the movement of a virtual hand or the onset of a tone that resulted from a button press. Such temporal sensorimotor discrepancies reduce the sense of agency. It remains unclear whether movement-related feedback is processed differently than outcome-related feedback in terms of agency experience, especially if these types of feedback differ with respect to sensory modality. We employed a mixed-reality setup, in which participants tracked their finger movements by means of a virtual hand. They performed a single tap, which elicited a sound. The temporal contingency between the participants' finger movements and (i the movement of the virtual hand or (ii the expected auditory outcome was systematically varied. In a visual control experiment, the tap elicited a visual outcome. For each feedback type and participant, changes in the sense of agency were quantified using a forced-choice paradigm and the Method of Constant Stimuli. Participants were more sensitive to delays of outcome than to delays of movement execution. This effect was very similar for visual or auditory outcome delays. Our results indicate different contributions of movement- versus outcome-related sensory feedback to the sense of agency, irrespective of the modality of the outcome. We propose that this differential sensitivity reflects the behavioral importance of assessing authorship of the outcome of an action.

Extended-release niacin/laropiprant significantly improves lipid levels in type 2 diabetes mellitus irrespective of baseline glycemic control

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Bays HE

2015-02-01

Full Text Available Harold E Bays,1 Eliot A Brinton,2 Joseph Triscari,3 Erluo Chen,3 Darbie Maccubbin,3 Alexandra A MacLean,3 Kendra L Gibson,3 Rae Ann Ruck,3 Amy O Johnson-Levonas,3 Edward A O’Neill,3 Yale B Mitchel3 1Louisville Metabolic & Atherosclerosis Research Center (L-MARC, Louisville, KY, USA; 2Utah Foundation for Biomedical Research, Salt Lake City, UT, USA; 3Merck & Co, Inc., Whitehouse Station, NJ, USA Background: The degree of glycemic control in patients with type 2 diabetes mellitus (T2DM may alter lipid levels and may alter the efficacy of lipid-modifying agents. Objective: Evaluate the lipid-modifying efficacy of extended-release niacin/laropiprant (ERN/LRPT in subgroups of patients with T2DM with better or poorer glycemic control. Methods: Post hoc analysis of clinical trial data from patients with T2DM who were randomized 4:3 to double-blind ERN/LRPT or placebo (n=796, examining the lipid-modifying effects of ERN/LRPT in patients with glycosylated hemoglobin or fasting plasma glucose levels above and below median baseline levels. Results: At Week 12 of treatment, ERN/LRPT significantly improved low-density lipoprotein cholesterol, high-density lipoprotein cholesterol (HDL-C, non-high-density lipoprotein cholesterol, triglycerides, and lipoprotein (a, compared with placebo, with equal efficacy in patients above or below median baseline glycemic control. Compared with placebo, over 36 weeks of treatment more patients treated with ERN/LRPT had worsening of their diabetes and required intensification of antihyperglycemic medication, irrespective of baseline glycemic control. Incidences of other adverse experiences were generally low in all treatment groups. Conclusion: The lipid-modifying effects of ERN/LRPT are independent of the degree of baseline glycemic control in patients with T2DM (NCT00485758. Keywords: lipid-modifying agents, hyperglycemia, LDL, HDL, triglycerides

The persistence of maternal vitamin D deficiency and insufficiency during pregnancy and lactation irrespective of season and supplementation.

Science.gov (United States)

Kramer, Caroline K; Ye, Chang; Swaminathan, Balakumar; Hanley, Anthony J; Connelly, Philip W; Sermer, Mathew; Zinman, Bernard; Retnakaran, Ravi

2016-05-01

Pregnancy and lactation comprise a critical window spanning all seasons during which maternal vitamin D status potentially may influence the long-term health of the newborn. Women typically receive calcium/vitamin D supplementation through antenatal vitamins, but there has been limited serial evaluation of maternal vitamin D status across this critical window. In this prospective observational cohort study, 467 women in Toronto, Canada, underwent measurement of serum 25-hydroxy vitamin D (25-OH-D) at mean 29·7 ± 2·9 weeks' gestation, 3 months postpartum and 12 months postpartum, enabling serial assessment across 3 seasons. At each assessment, vitamin D status was classified as deficiency (25-OH-Dl), insufficiency (25-OH-D≥50 nmol/l and l) or sufficiency (25-OH-D≥75 nmol/l). The prevalence rates of vitamin D deficiency and insufficiency were 31·5% and 35·1% in pregnancy, 33·4% and 35·3% at 3 months, and 35·6% and 33·8% at 12 months postpartum, respectively. These high rates remained stable over time (P = 0·49) despite declining usage of antenatal calcium/vitamin D supplementation from pregnancy to 3 months to 12 months postpartum (P vitamin D deficiency and insufficiency in pregnancy were independently associated with decrements in average 25-OH-D over time of 49·6 nmol/l and 26·4 nmol/l, respectively (both P vitamin D supplements were independently associated with changes in 25-OH-D in the range of 3-5 nmol/l (both P vitamin D deficiency/insufficiency during pregnancy and lactation, irrespective of season and supplementation, supports the emerging concept that current vitamin D supplementation in antenatal care is likely inadequate. © 2015 John Wiley & Sons Ltd.

Directory of national competent authorities' approval certificates for package design, special form material and shipment of radioactive material. 2002 ed

International Nuclear Information System (INIS)

2002-08-01

The current edition of the transport Regulations was published in 1996 and is more commonly referred to as 'ST-1'. Earlier Editions were known as Safety Series No. 6. The latest English reprint (2000) is now identified as TS-R-1 (ST-1, Revised). The transport Regulations elaborate requirements for the design, fabrication and maintenance of packaging as well as those for preparation, consigning, handling, carriage, storage in transit and receipt of the packages at final destination. Approval issued in the form of certificates is required for the design or shipment of packages. This report supersedes IAEA-TECDOC-1237 Directory of National Competent Authorities' Approval Certificates for Package Design, Special Form Material and Shipment of Radioactive Material, 2001 Edition. It is distributed worldwide to the IAEA Member States' competent authorities for transport, and other entities who have requested copies. Electronic copies of the main data file are provided to registered users of the PACKTRAM database. The information contained in this report is given in six tables. In each of these, information is presented in alphabetical order based on the certificate number. Tables 1 to 4 present administrative data including issue and expiry dates, package identification, package serial numbers, modes for which the package/shipment is approved and the edition of the IAEA Transport Safety Regulations on which the approval has been based. The technical information on package mass, authorized contents, and detailed and general description of the package are contained in Table 5. Table 6 shows the certificates reported to the Secretariat by each participating Member State

Directory of national competent authorities' approval certificates for package design, special form material and shipment of radioactive material. 2001 edition

International Nuclear Information System (INIS)

2001-08-01

The current edition of the transport Regulations was published in 1996 and is more commonly referred to as 'ST-1'. Earlier Editions were known as Safety Series No. 6. The latest English reprint (2000) is now identified as TS-R-1 (ST-1, Revised). The transport Regulations elaborate requirements for the design, fabrication and maintenance of packaging as well as those for preparation, consigning, handling, carriage, storage in transit and receipt of the packages at final destination. Approval issued in the form of certificates is required for the design or shipment of packages. This report supersedes IAEA-TECDOC-1171 D irectory of National Competent Authorities' Approval Certificates for Package Design, Special Form Material and Shipment of Radioactive Material, 2000 Edition . It is distributed worldwide to the IAEA Member States' competent authorities for transport, and other entities who have requested copies. Electronic copies of the main data file are provided to registered users of the PACKTRAM database. The information contained in this report is given in six tables. In each of these, information is presented in alphabetical order based on the certificate number. Tables 1 to 4 present administrative data including issue and expiry dates, package identification, package serial numbers, modes for which the package/shipment is approved and the edition of the IAEA Transport Safety Regulations on which the approval has been based. The technical information on package mass, authorized contents, and detailed and general description of the package are contained in Table 5. Table 6 shows the certificates reported to the Secretariat by each participating Member State

Industrial precipitation of yttrium chloride and zirconyl chloride: Effect of pH on ceramic properties for yttria partially stabilised zirconia

International Nuclear Information System (INIS)

Carter, G.A.; Hart, R.D.; Rowles, M.; Ogden, M.I.; Buckley, C.E.

2009-01-01

Two 3 mol% partially stabilised zirconia (P-SZ) samples suitable for the SOFC market were manufactured from solutions through to ceramics using a method similar to a known industrial process. The only difference in preparation of the two 3 mol% P-SZ samples was the pH of precipitation which was set at pH 3 or 12. Particle size measurements by dynamic light scattering were used to characterise the precipitate and the filtration rates were investigated. Five point N 2 -BET was used to investigate the specific surface area before and after calcination with the response to temperature tracked. Similarly TGA/DTA investigation was used to determine the calcination point during all of these tests and it was found that both powders behaved similarly. XRD-Rietveld analysis incorporating in situ and ex situ calcination revealed that the pH 3 sample had more monoclinic phase present after calcination and sintering as a ceramic. Ceramic testing incorporating hardness (Vickers), toughness (K 1C ), MOR, density and grain sizing was carried out, all determined that the material produced at pH 12 was superior for SOFC applications than the pH 3 sample. Further investigation using TEM-EDS revealed that the processing of the pH 3 powder had allowed a lower concentration of the yttrium which was incorporated at approximately 2 mol% instead of the required 3. ICP-OES of the after filter liquor indicated that high concentrations of yttrium (797 ppm) were found in the solution with the wash solution having 149 ppm yttrium. In contrast the pH 12 samples had 7 ppm in both the after filter liquor and wash indicating that the yttrium is bound within the matrix more completely at the higher pH.

A New TS Algorithm for Solving Low-Carbon Logistics Vehicle Routing Problem with Split Deliveries by Backpack—From a Green Operation Perspective

Science.gov (United States)

Fu, Zhuo; Wang, Jiangtao

2018-01-01

In order to promote the development of low-carbon logistics and economize logistics distribution costs, the vehicle routing problem with split deliveries by backpack is studied. With the help of the model of classical capacitated vehicle routing problem, in this study, a form of discrete split deliveries was designed in which the customer demand can be split only by backpack. A double-objective mathematical model and the corresponding adaptive tabu search (TS) algorithm were constructed for solving this problem. By embedding the adaptive penalty mechanism, and adopting the random neighborhood selection strategy and reinitialization principle, the global optimization ability of the new algorithm was enhanced. Comparisons with the results in the literature show the effectiveness of the proposed algorithm. The proposed method can save the costs of low-carbon logistics and reduce carbon emissions, which is conducive to the sustainable development of low-carbon logistics. PMID:29747469

A New TS Algorithm for Solving Low-Carbon Logistics Vehicle Routing Problem with Split Deliveries by Backpack-From a Green Operation Perspective.

Science.gov (United States)

Xia, Yangkun; Fu, Zhuo; Tsai, Sang-Bing; Wang, Jiangtao

2018-05-10

In order to promote the development of low-carbon logistics and economize logistics distribution costs, the vehicle routing problem with split deliveries by backpack is studied. With the help of the model of classical capacitated vehicle routing problem, in this study, a form of discrete split deliveries was designed in which the customer demand can be split only by backpack. A double-objective mathematical model and the corresponding adaptive tabu search (TS) algorithm were constructed for solving this problem. By embedding the adaptive penalty mechanism, and adopting the random neighborhood selection strategy and reinitialization principle, the global optimization ability of the new algorithm was enhanced. Comparisons with the results in the literature show the effectiveness of the proposed algorithm. The proposed method can save the costs of low-carbon logistics and reduce carbon emissions, which is conducive to the sustainable development of low-carbon logistics.

Constraining |V(td)|/|V(ts)| Using Radiative Penguin B -> V(K*/rho/omega)gamma Decays

International Nuclear Information System (INIS)

Tan, Ping

2006-01-01

Exclusive radiative penguin B decays, B → (K* 0 /K* + )γ and B → (ρ/ω)γ, are flavor-changing neutral-current (FCNC) processes. Studies of these decays are of special interest in testing Standard Model (SM) predictions and searching for other beyond-the-SM FCNC interactions. Using 89 x 10 6 B(bar B) pairs from BABAR, we measure the branching fraction (Β), CP-asymmetry (Α), and isospin asymmetry (Δ 0- ) of B → (K* 0 /K* + )γ as follows: Β(B 0 → K* 0 γ) = 3.92 ± 0.20(stat.) ± 0.24(syst.); Β(B + → K* + γ) = 3.87 ± 0.28(stat.) ± 0.26(syst.); Α(B → K*γ) = 0.013 ± 0.36(stat.) ± 0.10(syst.); Δ 0- (B → K*γ) = 0.050 ± 0.045(stat.) ± 0.028(syst.) ± 0.024(R +/0 ). The 90% confidence intervals for the CP-asymmetry and the isospin-asymmetry in the B → K*γ decay are given as: -0.074 0- (B → K*γ) 6 B(bar B) pairs from BABAR. No evidence for these decays is found. We set the upper limits at 90% confidence level for these decays: Β(B 0 → ρ 0 γ) -6 , Β(B + → ρ + γ) -6 , Β(B 0 → ωγ) -6 , (bar Β)(B → (ρ/ω)γ) -6 . These results are in good agreement with the SM predictions. The branching fractions of these decays are then used to constrain the ratio |V td |/|V ts |

The rate of charge tunneling is insensitive to polar terminal groups in self-assembled monolayers in Ag(TS)S(CH2)(n)M(CH2)(m)T//Ga2O3/EGaIn junctions.

Science.gov (United States)

Yoon, Hyo Jae; Bowers, Carleen M; Baghbanzadeh, Mostafa; Whitesides, George M

2014-01-08

This paper describes a physical-organic study of the effect of uncharged, polar, functional groups on the rate of charge transport by tunneling across self-assembled monolayer (SAM)-based large-area junctions of the form Ag(TS)S(CH2)(n)M(CH2)(m)T//Ga2O3/EGaIn. Here Ag(TS) is a template-stripped silver substrate, -M- and -T are "middle" and "terminal" functional groups, and EGaIn is eutectic gallium-indium alloy. Twelve uncharged polar groups (-T = CN, CO2CH3, CF3, OCH3, N(CH3)2, CON(CH3)2, SCH3, SO2CH3, Br, P(O)(OEt)2, NHCOCH3, OSi(OCH3)3), having permanent dipole moments in the range 0.5 < μ < 4.5, were incorporated into the SAM. A comparison of the electrical characteristics of these junctions with those of junctions formed from n-alkanethiolates led to the conclusion that the rates of charge tunneling are insensitive to the replacement of terminal alkyl groups with the terminal polar groups in this set. The current densities measured in this work suggest that the tunneling decay parameter and injection current for SAMs terminated in nonpolar n-alkyl groups, and polar groups selected from common polar organic groups, are statistically indistinguishable.

Pharmacological characterisation of α6β4* nicotinic acetylcholine receptors assembled from three different α6/α3 subunit chimeras in tsA201 cells

DEFF Research Database (Denmark)

Jensen, Anne Bjørnskov; Hoestgaard-Jensen, Kirsten; Jensen, Anders A.

2014-01-01

by their inefficient functional expression in vitro. In the present study we have characterized and compared the pharmacological properties displayed by α6β4 and α6β4β3 nicotinic acetylcholine receptors assembled in tsA201 cells from the classical α6/α3 chimera (C1) and two novel α6/α3 chimeras (C6F223L and C16F223L...... should be made keeping the molecular modifications in the α6 surrogate subunits in mind, this study sheds light on the pharmacological properties of α6β4⁎ nicotinic acetylcholine receptors and demonstrates the applicability of the C6F223L and C16F223L chimeras for studies of these receptors....

Plan comunicacional para incrementar las ventas y participación de mercado de la empresa ALVESA, ubicada en la ciudad de Santo Domingo, provincia Santo Domingo de los Tsáchilas.

OpenAIRE

Alvarado Muñoz, Héctor Patricio

2017-01-01

Se elaboró un Plan Comunicacional para incrementar las ventas y la participación en el mercado de los productos que distribuye la empresa ALVESA, ubicada de la ciudad de Santo Domingo, provincia Santo Domingo de los Tsáchilas. Se realizó un profundo análisis sobre la situación actual de la empresa para identificar los problemas que afectan los factores antes mencionados, determinándose así que no existe un proceso comunicacional adecuado que posibilite el fortalecimiento de la...

The European efforts in development of new high temperature rotor materials - COST536

Energy Technology Data Exchange (ETDEWEB)

Kern, T.U. [Siemens Energy, Muehlheim (Germany); Mayer, K.H. [Alstom Power, Nuernberg (Germany); Donth, B. [Saarschmiede, Voelklingen (Germany); Zeiler, G. [Boehler Schmiedetechnik, Kapfenberg (Austria); Di Gianfrancesco, A. [CSM, Roma (Italy)

2010-07-01

Despite the ongoing efforts to increase the amount of available alternative energy sources, fossil fuels such as lignite and hard coal will remain important for the energy mix and sustainability of energy supply. Fossil-fuelled Steam Power Plants (SSP's) or Combined Cycle power plants (CCPP's) will also continue to supply a significant portion of our energy needs. Within the frame of European COST536, a new project was installed with the aim of Alloy development for Critical Components of Environmentally friendly Power planTs (ACCEPT) aiming for material solutions for steam conditions up to 650 C. Martensitic materials should be used for thick-walled components to maintain high operational flexibility of such large plants. Rotors, casings, bolts, tubes, pipes, and water walls, are the critical components under current investigation. The class of the 9-12%Cr steels offers the highest potential to meet the required property levels for critical components such as rotor forgings. Therefore a significant effort to increase the application temperature of these steels was and is the focus of studies within Europe. Although there are 600 C materials already being successfully utilised in a number of advanced European power plants, further improvement in creep strength is being achieved by the addition of Boron and a well balanced Co content. Full-size prototype components are now being tested. New ideas to improve the behaviour and increase the application temperatures are under investigation. Results are reported here. (orig.)

Lubâb At-Ta’wîl ‘Inda Al-Imâm Al-Khâzîn Baina Al-Ma’tsûr wa Ar-Ra’yi (Dirâsah Maudhu’iyyah fi Ayah al-Qashash

Directory of Open Access Journals (Sweden)

Muhammad Shulhi Alhadi siregar

2018-03-01

Full Text Available This paper concern to study about one of Tafseer book, namely Lubâb al-Ta'wîl fi Ma'âny at-Tanzîl by Imam al-Khazin. Some scholars differ in the setting of sources of tafseer. Such as, the well-known scholars, Muhammad Ali Iyazi and Muhammad Husain ad-Dzahabi. Ulama Iyazi assumes that Tafseer Khazin belongs to the category of commentary bi al-Ma'tsûr, since this commentary is an ikhtishar of Tafseer al-Baghawi. While some scholars such as adz-Dzahabi, categorized this tafseer into the bi al-Ra'yi. By using the tahlily documentation method and the thematic method associated with Qashash verses in the Qur'an, the researchers found the correct method, namely the tafseer of al-Atsary an-Nazhary or known by tafseer bi al-Ma'tsûr who use Ra'yi as an extension of explanation and the determination of the most powerful law, seen from writing theme related at the end of its tafseer.

The influence of hard segment content on mechanical and thermal properties of polycarbonate-based polyurethane materials

Directory of Open Access Journals (Sweden)

Budinski-Simendić Jaroslava

2012-01-01

Full Text Available Aliphatic segmented polyurethanes were prepared by one-step procedure in catalytic reaction between polycarbonate diol, hexamethylene-diisocyanate and 1,4-butandiol (as chain extender. The hard segment content TS was varied (17, 24, 30 and 42 wt. % by changing the ratio of starting compounds. The soft segment is made from flexible aliphatic polycarbonate diol, while hard segments consist of chain extender and diisocyanate component. In order to study the hydrogen bonding formation and phase separation, Fourier transform infrared spectroscopy (FT-IR was used. Wide angle X-ray scattering (WAXS was performed to determine a degree of crystallinity and to investigate the phase behavior of prepared elastomers. The effect of TS content on mechanical properties (tensile strength, elongation at break and hardness was tested. Thermal behavior of prepared novel polycarbonate-based polyurethanes was investigated using differential scanning callorimetry (DSC. It was determined that the elastomer which contains the highest amount of urethane groups in its structure (TS content of 42 wt. % exhibits the most pronounced phase separation and the highest degree of crystallinity. All prepared polyurethanes exhibit high elongation at break (over 700%. The glass transition temperature Tg of prepared samples was in the temperature region from −39 to −36°C, and it was found to be slightly influenced by the soft segment content. The enthalpy of chain segments relaxation in diffused region between hard and soft domains (detected in the temperature range from 35 to 55 °C was decreased with the increase of hard segment content. The multiple melting of hard segments (connected with the dissruption of physical crosslinks appeared above 100 °C. It was found that the melting enthalpy linearly increases with the increase of urethane group content. Sample with 42 wt. % of TS has the highest value of melting enthalpy (41.5 J/g.

Wear Characterization of Carbon Nanotubes Reinforced Acetal Spur, Helical, Bevel and Worm Gears Using a TS Universal Test Rig

Science.gov (United States)

Yousef, Samy; Osman, T. A.; Abdalla, Abdelrahman H.; Zohdy, Gamal A.

2015-12-01

Although the applications of nanotechnologies are increasing, there remains a significant barrier between nanotechnology and machine element applications. This work aims to remove this barrier by blending carbon nanotubes (CNT) with common types of acetal polymer gears (spur, helical, bevel and worm). This was done by using adhesive oil (paraffin) during injection molding to synthesize a flange and short bars containing 0.02% CNT by weight. The flanges and short bars were machined using hobbing and milling machines to produce nanocomposite polymer gears. Some defects that surfaced in previous work, such as the appearance of bubbles and unmelted pellets during the injection process, were avoided to produce an excellent dispersion of CNT in the acetal. The wear resistances of the gears were measured by using a TS universal test rig using constant parameters for all of the gears that were fabricated. The tests were run at a speed of 1420 rpm and a torque of 4 Nm. The results showed that the wear resistances of the CNT/acetal gears were increased due to the addition of CNT, especially the helical, bevel and worm gears.

Dispersion and rheological studies of Y–PSZ tape casting slurry

Indian Academy of Sciences (India)

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This stem from the interesting variety of pro- perties that can be ... solid oxide fuel cells, oxygen sensors and structural com- posites (e.g. ... profound effect on the microstructure of the green body. Breaking of ... repulsion as a result of development of an electrical double layer around ... of time against the initial height (H0).

Tobacco Stem-Based Activated Carbons for High Performance Supercapacitors

Science.gov (United States)

Xia, Xiaohong; Liu, Hongbo; Shi, Lei; He, Yuede

2012-09-01

Tobacco stem-based activated carbons (TS-ACs) were prepared by simple KOH activation and their application as electrodes in the electrical double layer capacitor (EDLC) performed successfully. The BET surface area, pore volume, and pore size distribution of the TS-ACs were evaluated based on N2 adsorption isotherms at 77 K. The surface area of the obtained activated carbons varies over a wide range (1472.8-3326.7 m2/g) and the mesoporosity was enhanced significantly as the ratio of KOH to tobacco stem (TS) increased. The electrochemical behaviors of series TS-ACs were characterized by means of galvanostatic charging/discharging, cyclic voltammetry, and impedance spectroscopy. The correlation between electrochemical properties and pore structure was investigated. A high specific capacitance value as 190 F/g at 1 mA/cm2 was obtained in 1 M LiPF6-EC/DMC/DEC electrolyte solution. Furthermore, good performance is also achieved even at high current densities. A development of new use for TS into a valuable energy storage material is explored.

Effect of artificial toothbrushing and water storage on the surface roughness and micromechanical properties of tooth-colored CAD-CAM materials.

Science.gov (United States)

Flury, Simon; Diebold, Elisabeth; Peutzfeldt, Anne; Lussi, Adrian

2017-06-01

Because of the different composition of resin-ceramic computer-aided design and computer-aided manufacturing (CAD-CAM) materials, their polishability and their micromechanical properties vary. Moreover, depending on the composition of the materials, their surface roughness and micromechanical properties are likely to change with time. The purpose of this in vitro study was to investigate the effect of artificial toothbrushing and water storage on the surface roughness (Ra and Rz) and the micromechanical properties, surface hardness (Vickers [VHN]) and indentation modulus (E IT ), of 5 different tooth-colored CAD-CAM materials when polished with 2 different polishing systems. Specimens (n=40 per material) were cut from a composite resin (Paradigm MZ100; 3M ESPE), a feldspathic ceramic (Vitablocs Mark II; Vita Zahnfabrik), a resin nanoceramic (Lava Ultimate; 3M ESPE), a hybrid dental ceramic (Vita Enamic; Vita Zahnfabrik), and a nanocomposite resin (Ambarino High-Class; Creamed). All specimens were roughened in a standardized manner and polished either with Sof-Lex XT discs or the Vita Polishing Set Clinical. Surface roughness, VHN, and E IT were measured after polishing and after storage for 6 months (tap water, 37°C) with periodic, artificial toothbrushing. The surface roughness, VHN, and E IT results were analyzed with a nonparametric ANOVA followed by Kruskal-Wallis and exact Wilcoxon rank sum tests (α=.05). Irrespective of polishing system and of artificial toothbrushing and storage, Lava Ultimate generally showed the lowest surface roughness and Vitablocs Mark II the highest. As regards micromechanical properties, the following ranking of the CAD-CAM materials was found (from highest VHN/E IT to lowest VHN/E IT ): Vitablocs Mark II > Vita Enamic > Paradigm MZ100 > Lava Ultimate > Ambarino High-Class. Irrespective of material and of artificial toothbrushing and storage, polishing with Sof-Lex XT discs resulted in lower surface roughness than the Vita Polishing

Biocompatibility of biomaterials - Lessons learned and considerations for the design of novel materials.

Science.gov (United States)

Schmalz, Gottfried; Galler, Kerstin M

2017-04-01

Biocompatibility of dental materials has gained increasing interest during recent decades. Meanwhile, legal regulations and standard test procedures are available to evaluate biocompatibility. Herein, these developments will be exemplarily outlined and some considerations for the development of novel materials will be provided. Different aspects including test selection, release of substances, barriers, tissue healing, antibacterial substances, nanoparticles and environmental aspects will be covered. The provided information is mainly based on a review of the relevant literature in international peer reviewed journals, on regulatory documents and on ISO standards. Today, a structured and systematic approach for demonstrating biocompatibility from both a scientific and regulatory point of view is based on a clinical risk assessment in an early stage of material development. This includes the analysis of eluted substances and relevant barriers like dentin or epithelium. ISO standards 14971, 10993, and 7405 specify the modes for clinical risk assessment, test selection and test performance. In contact with breached tissues, materials must not impair the healing process. Antibacterial effects should be based on timely controllable substances or on repellant surfaces. Nanoparticles are produced by intraoral grinding irrespective of the content of nanoparticles in the material, but apparently at low concentrations. Concerns regarding environmental aspects of mercury from amalgam can be met by amalgam separating devices. The status for other materials (e.g. bisphenol-A in resin composites) needs to be evaluated. Finally, the public interest for biocompatibility issues calls for a suitable strategy of risk communication. A wise use of the new tools, especially the clinical risk assessment should aim at preventing the patients, professionals and the environment from harm but should not block the development of novel materials. However, biocompatibility must always be

Characterization of lignocellulolytic activities from fungi isolated from the deep-sea sponge Stelletta normani.

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Ramón Alberto Batista-García

Full Text Available Extreme habitats have usually been regarded as a source of microorganisms that possess robust proteins that help enable them to survive in such harsh conditions. The deep sea can be considered an extreme habitat due to low temperatures (<5°C and high pressure, however marine sponges survive in these habitats. While bacteria derived from deep-sea marine sponges have been studied, much less information is available on fungal biodiversity associated with these sponges. Following screening of fourteen fungi isolated from the deep-sea sponge Stelletta normani sampled at a depth of 751 metres, three halotolerant strains (TS2, TS11 and TS12 were identified which displayed high CMCase and xylanase activities. Molecular based taxonomic approaches identified these strains as Cadophora sp. TS2, Emericellopsis sp. TS11 and Pseudogymnoascus sp. TS 12. These three fungi displayed psychrotolerance and halotolerant growth on CMC and xylan as sole carbon sources, with optimal growth rates at 20°C. They produced CMCase and xylanase activities, which displayed optimal temperature and pH values of between 50-70°C and pH 5-8 respectively, together with good thermostability and halotolerance. In solid-state fermentations TS2, TS11 and TS12 produced CMCases, xylanases and peroxidase/phenol oxidases when grown on corn stover and wheat straw. This is the first time that CMCase, xylanase and peroxidase/phenol oxidase activities have been reported in these three fungal genera isolated from a marine sponge. Given the biochemical characteristics of these ligninolytic enzymes it is likely that they may prove useful in future biomass conversion strategies involving lignocellulosic materials.

Characterization of lignocellulolytic activities from fungi isolated from the deep-sea sponge Stelletta normani.

Science.gov (United States)

Batista-García, Ramón Alberto; Sutton, Thomas; Jackson, Stephen A; Tovar-Herrera, Omar Eduardo; Balcázar-López, Edgar; Sánchez-Carbente, María Del Rayo; Sánchez-Reyes, Ayixon; Dobson, Alan D W; Folch-Mallol, Jorge Luis

2017-01-01

Extreme habitats have usually been regarded as a source of microorganisms that possess robust proteins that help enable them to survive in such harsh conditions. The deep sea can be considered an extreme habitat due to low temperatures (<5°C) and high pressure, however marine sponges survive in these habitats. While bacteria derived from deep-sea marine sponges have been studied, much less information is available on fungal biodiversity associated with these sponges. Following screening of fourteen fungi isolated from the deep-sea sponge Stelletta normani sampled at a depth of 751 metres, three halotolerant strains (TS2, TS11 and TS12) were identified which displayed high CMCase and xylanase activities. Molecular based taxonomic approaches identified these strains as Cadophora sp. TS2, Emericellopsis sp. TS11 and Pseudogymnoascus sp. TS 12. These three fungi displayed psychrotolerance and halotolerant growth on CMC and xylan as sole carbon sources, with optimal growth rates at 20°C. They produced CMCase and xylanase activities, which displayed optimal temperature and pH values of between 50-70°C and pH 5-8 respectively, together with good thermostability and halotolerance. In solid-state fermentations TS2, TS11 and TS12 produced CMCases, xylanases and peroxidase/phenol oxidases when grown on corn stover and wheat straw. This is the first time that CMCase, xylanase and peroxidase/phenol oxidase activities have been reported in these three fungal genera isolated from a marine sponge. Given the biochemical characteristics of these ligninolytic enzymes it is likely that they may prove useful in future biomass conversion strategies involving lignocellulosic materials.

Advanced Joining of Aerospace Metallic Materials.

Science.gov (United States)

1986-07-01

REPAIRED F100 TURBINE VANES tUNDER SIMULATED) SERVICE. CONDI rIONS by A.,I.A.Mom. N.M.Madhava. G.A.KooI and M.IDean 21 REPAIR TECHNIQU ES FOR GAS lII... vapeurs d~gag~es par la decomposition des corps exog~nes. POe) Les cavi t~s (cavit)(fgr4, sont le propre du soudage des fortes paisseurs. Ellas...the most practical information with respect to mechanical properties for gas turbine applications. Generally, sound laser welds (i.e. free from

Comment on the Nanoparticle Conclusions in Crüts et al. (2008, "Exposure to diesel exhaust induces changes in EEG in human volunteers"

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Long Christopher M

2008-07-01

Full Text Available Abstract A recent publication in this journal reported interesting changes in electroencephalographic (EEG waves that occurred in 10 young, male volunteers following inhalation for one hour of elevated levels of diesel-engine exhaust fumes 1. The authors then proposed a chain of causal events that they hypothesized underlay their observed EEG changes. Their reasoning linked the observed results to nanoparticles in diesel-engine exhaust (DEE, and went on to suggest that associations between changes in ambient particulate matter (PM levels and changes in health statistics might be due to the effects of diesel-engine exhaust (DEE nanoparticles on EEG. We suggest that the extrapolations of the Crüts et al. EEG findings to casual mechanisms about how ambient levels of DEE particulate might affect electrical signals in the brain, and subsequently to how DEE particulate might alter disease risk, are premature.

Design and baseline characteristics of the Short bouTs of Exercise for Preschoolers (STEP) study.

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Alhassan, Sofiya; Nwaokelemeh, Ogechi; Mendoza, Albert; Shitole, Sanyog; Whitt-Glover, Melicia C; Yancey, Antronette K

2012-08-01

Most preschool centers provide two 30-min sessions of gross-motor/outdoor playtime per preschool day. Within this time frame, children accumulate most of their activity within the first 10 min. This paper describes the design and baseline participant characteristics of the Short bouTs of Exercise for Preschoolers (STEP) study. The STEP study is a cluster randomized controlled study designed to examine the effects of short bouts of structured physical activity (SBS-PA) implemented within the classroom setting as part of designated gross-motor playtime on during-school physical activity (PA) in preschoolers. Ten preschool centers serving low-income families were randomized into SBS-PA versus unstructured PA (UPA). SBS-PA schools were asked to implement age-appropriate 10 min structured PA routines within the classroom setting, twice daily, followed by 20 min of usual unstructured playtime. UPA intervention consisted of 30 min of supervised unstructured free playtime twice daily. Interventions were implemented during the morning and afternoon designated gross-motor playtime for 30 min/session, five days/week for six months. Outcome measures were between group difference in during-preschool PA (accelerometers and direct observation) over six-months. Ten preschool centers, representing 34 classrooms and 315 children, enrolled in the study. The average age and BMI percentile for the participants was 4.1 ± 0.8 years and 69th percentile, respectively. Participants spent 74% and 6% of their preschool day engaged in sedentary and MVPA, respectively. Results from the STEP intervention could provide evidence that a PA policy that exposes preschoolers to shorter bouts of structured PA throughout the preschool day could potentially increase preschoolers' PA levels.

Cellular transport of lutein is greater from uncooked rather than cooked spinach irrespective of whether it is fresh, frozen, or canned.

Science.gov (United States)

O'Sullivan, Laurie; Ryan, Lisa; Aherne, S Aisling; O'Brien, Nora M

2008-08-01

Lutein, a carotenoid found in significant levels in spinach, has attracted a great deal of attention owing to its reported function as a shield against the photooxidative effects of blue light. Therefore, the rationale of this study was to examine the effects of various processing and cooking methods on lutein bioavailability from spinach (Spinacia oleracea) using an in vitro digestion procedure coupled with the use of a human intestinal Caco-2 cell model. Fresh, frozen, and canned spinach were analyzed uncooked and after boiling or microwave cooking. Lutein content from the uncooked and cooked digested food (digestate) and appropriate micelles was determined. Micellarized lutein from the spinach samples was adjusted to 0.1 micromol/L and added to Caco-2 cells. Cellular uptake and secretion (cellular transport) of lutein were determined. Our results showed that digestate obtained from uncooked canned spinach had greater lutein content (P canned spinach digestate and micelles compared with their uncooked counterparts. Interestingly, there were no differences in the micellarization of lutein between the cooking and processing methods. Cellular transport of lutein was greater from uncooked spinach micelles compared with boiled or microwave-cooked spinach. To conclude, although the lutein content of digesta and micelles may have been modified, its micellarization was not significantly affected by any of the cooking or processing methods tested. In general, cellular transport of lutein was greatest in uncooked spinach irrespective of whether the spinach was fresh, frozen, or canned.

Transverse susceptibility as a probe of the magnetocrystalline anisotropy-driven phase transition in Pr0.5Sr0.5CoO3

Science.gov (United States)

Frey Huls, N. A.; Bingham, N. S.; Phan, M. H.; Srikanth, H.; Stauffer, D. D.; Leighton, C.

2011-01-01

Half-doped Pr1-xSrxCoO3 (x=0.5) displays anomalous magnetism, most notably manifest in the field-cooled magnetization versus temperature curves under different applied cooling fields. Recently, an explanation was advanced that a magnetocrystalline anisotropy transition driven by a structural transition at 120 K is the origin of this behavior. In this paper, we further elucidate the nature of the magnetic anisotropy across the low-temperature phase transition in this material by means of transverse susceptibility (TS) measurements performed using a self-resonant tunnel diode oscillator. TS probes magnetic materials by means of a small radio frequency oriented transverse to a dc field that sweeps from positive to negative saturation. TS scans as a function of field clearly reveal peaks associated with the anisotropy (HK) and switching fields (HS). When peak position is examined as a function of temperature, ˜120 K the signature of a ferromagnetic-to-ferromagnetic phase transition is evident as a sharp feature in HK and a corresponding cusp in HS. A third TS peak (not previously observed in other classes of magnetic oxides such as manganites and spinel ferrites) is found to be correlated with the crossover field (Hcr) in the unconventional magnetization versus temperature [M(T)] behavior. We observe a strong temperature dependence of Hcr at ˜120 K using this technique, which suggests the magnetic-field-influenced magnetocrystalline anisotropy transition. We show the switching between the high-field magnetization state and the low-field magnetization state associated with the magnetocrystalline anisotropy transition is irreversible when the magnetic field is recycled. Finally, we demonstrate that the TS peak magnitude indicates easy axis switching associated with this phase transition, even in these polycrystalline samples. Our results further confirm that TS provides new insights into the magnetic behavior of complex oxides.

Eco-friendly dry chemo-mechanical pretreatments of lignocellulosic biomass: Impact on energy and yield of the enzymatic hydrolysis

International Nuclear Information System (INIS)

Barakat, Abdellatif; Chuetor, Santi; Monlau, Florian; Solhy, Abderrahim; Rouau, Xavier

2014-01-01

Highlights: • Innovative dry NaOH chemo-mechanical pretreatment was developed. • Dry (TS dry ) and dilute (TS dilute ) NaOH chemo-mechanical pretreatment were compared. • TS dilute consumed higher amounts of water and energy compared to TS dry . • Energy efficiency obtained for TS dilute was 0.417 kg glucose kW h −1 and 0.888 for TS dry . - Abstract: In this study, we developed an eco-friendly dry alkaline chemomechanical pretreatment of wheat straw without production of waste and liquid fractions with objective to save energy input, to decrease the environmental impact and to increase enzymatic hydrolysis. Wheat straw was pretreated with NH 3 , NaOH-H 2 O 2 , NH 3 -H 2 O 2 and NaOH at high materials concentration (5 kg/L) equivalent to biomass/liquid ratio of 1/5 (dry chemomechanical) and at low materials concentration (0.2 kg/L) equivalent to biomass/liquid ratio of 5/1 (dilute chemomechanical). Untreated and chemical treated wheat straw samples were subjected to grinding and milling following by enzymatic hydrolysis with commercial cellulases. NaOH and NaOH-H 2 O 2 dry chemomechanical pretreatments were found to be more effective in decreasing the particle size and energy consumption and increasing the surface area. However, alkaline dilute-chemomechanical treatments consumed higher amounts of water (5 L water/1 kg biomass) and energy compared to dry-chemomechanical treatments. In point of fact, the lowest energy efficiency obtained was 0.417 kg glucose kW h −1 for dilute-chemomechanical treatments compared to 0.888 kg glucose kW h −1 glucose kW h −1 for dry-chemomechanical treatments. Alkaline dry-chemomechanical pretreatments approach appears more attractive and efficient in terms of glucose, energy efficiency and environmental impact, compared to conventional alkaline chemomechanical pretreatments

Transport of radioactive material in Romania -the assessment of the radiological consequences and the environmental impacts

International Nuclear Information System (INIS)

Vieru, Gheorghe

2008-01-01

The transport of radioactive materials (RAM) is a very important problem considering the potential risks and radiological consequences in carrying-out this activity. Romania as a Member State of the International Atomic Energy Agency has implemented national regulations for a safe transport of RAM in accordance with the Agency's recommendations as well as other international specialized organizations. Based on the IAEA's Safety Standard-TS-R-1 (ST-1), Romanian National Nuclear Regulatory Body - CNCAN adopted and implemented, by Act no. 357/December 21, 2005, the safety regulations for the transport of radioactive materials in Romania under the title: 'Regulations for the Transport of Radioactive Materials'. The paper will present the main sources of radioactive materials in Romania their transportation routes with a particular interest paid to the radioactive wastes (low level radioactive materials), isotopes and radioactive sources, uranium ore. Starting from the fact that the safety in the transport of radioactive materials is dependent on appropriate packaging for the contents being shipped, rather than operational and/or administrative actions required for the package, the paper presents, briefly the main packages used for transport and storage of such RAM in Romania. There are presented hypothetical scenarios for specific problems related to the identification and evaluation of the risks and potential radiological consequences associated with the transport of radioactive materials in Romania, for all these three situations: routine transport (without incidents), normal transport (with minor incidents) and during possible accidents. As a conclusion, it is ascertained that the evaluated annual collective dose for the population due to RAM transport is less than that received by natural radiation sources. At the same time it is concluded that Romanian made packages are safe and prevent loss of their radioactive contents into the environment. (author)

A Patient with a Large Gastric Tumor and Protein-Losing Gastroenteropathy Successfully Treated with Neoadjuvant TS-1 Combined with CDDP Therapy

Directory of Open Access Journals (Sweden)

Tatsuya Hashimoto

2014-11-01

Full Text Available Gastric cancer with protein-losing gastroenteropathy is relatively rare worldwide. The most important problem for the treatment of these patients is their low nutritional status and protein level, which can cause severe postoperative complications. We report a 49-year-old Japanese female with a large gastric tumor and protein-losing gastroenteropathy successfully treated with neoadjuvant TS-1 combined with CDDP therapy. She had a type 5 tumor with partially cauliflower-like appearance. Her blood chemistry revealed low serum total protein (3.3 g/dl and low albumin (1.7 g/dl. She was additionally diagnosed with protein-losing gastroenteropathy based on 99mTc-human serum albumin scintigraphy. Initial neoadjuvant chemotherapy decreased the size of the tumor and led to a marked improvement in her serum protein levels. She then underwent a total gastrectomy and lymph node dissection (D2 with a combined resection of the spleen and gallbladder. Therefore, neoadjuvant chemotherapy may provide a safe treatment before definitive surgery for gastric cancer with protein-losing gastroenteropathy.

Studies on centrifugal clutch judder behavior and the design of frictional lining materials

Science.gov (United States)

Li, Tse-Chang; Huang, Yu-Wen; Lin, Jen-Fin

2016-01-01

This study examines the judder behavior of a centrifugal clutch from the start of hot spots in the conformal contact, then the repeated developments of thermoelastic instability, and finally the formation of cyclic undulations in the vibrations, friction coefficient and torque. This behavior is proved to be consistent with the testing results. Using the Taguchi method, 18 kinds of frictional lining specimens were prepared in order to investigate their performance in judder resistance and establish a relationship between judder behavior and the Ts/Td (Ts: static torque; Td: dynamic torque) and dμ/dVx (μ: friction coefficient; Vx: relative sliding velocity of frictional lining and clutch drum) parameters. These specimens are also provided to examine the effects and profitability with regard to the centrifugal clutch, and find the relative importance of the various control factors. Theoretical models for the friction coefficient (μ), the critical sliding velocity (Vc) with clutch judder, and the contact pressure ratio p* /pbar (p*: pressure undulation w.r.t. pbar; pbar: mean contact pressure) and temperature corresponding to judder behavior are developed. The parameters of the contact pressure ratio and temperature are shown to be helpful to explain the occurrence of judder. The frictional torque and the rotational speeds of the driveline, clutch, and clutch drum as functions of engagement time for 100 clutch cycles are obtained experimentally to evaluate dμ/dVx and Ts/Td. A sharp rise in the maximum p* /pbar occurred when the relative sliding velocity reached the critical velocity, Vc. An increase in the maximum p* /pbar generally led to an increase of the (initially negative) dμ/dVx value, and thus the severity of judder. The fluctuation intensity of dμ/dVx becomes a governing factor of the growth of dμ/dVx itself in the engagement process. The mean values of dμ/dVx and Ts/Td for the clutching tests with 100 cycles can be roughly divided into three groups

Piperlongumine inhibits the proliferation and survival of B-cell acute lymphoblastic leukemia cell lines irrespective of glucocorticoid resistance

International Nuclear Information System (INIS)

Han, Seong-Su; Han, Sangwoo; Kamberos, Natalie L.

2014-01-01

Highlights: • PL inhibits the proliferation of B-ALL cell lines irrespective of GC-resistance. • PL selectively kills B-ALL cells by increasing ROS, but not normal counterpart. • PL does not sensitize majority of B-ALL cells to DEX. • PL represses the network of constitutively activated TFs and modulates their target genes. • PL may serve as a new therapeutic molecule for GC-resistant B-ALL. - Abstract: Piperlongumine (PL), a pepper plant alkaloid from Piper longum, has anti-inflammatory and anti-cancer properties. PL selectively kills both solid and hematologic cancer cells, but not normal counterparts. Here we evaluated the effect of PL on the proliferation and survival of B-cell acute lymphoblastic leukemia (B-ALL), including glucocorticoid (GC)-resistant B-ALL. Regardless of GC-resistance, PL inhibited the proliferation of all B-ALL cell lines, but not normal B cells, in a dose- and time-dependent manner and induced apoptosis via elevation of ROS. Interestingly, PL did not sensitize most of B-ALL cell lines to dexamethasone (DEX). Only UoC-B1 exhibited a weak synergistic effect between PL and DEX. All B-ALL cell lines tested exhibited constitutive activation of multiple transcription factors (TFs), including AP-1, MYC, NF-κB, SP1, STAT1, STAT3, STAT6 and YY1. Treatment of the B-ALL cells with PL significantly downregulated these TFs and modulated their target genes. While activation of AURKB, BIRC5, E2F1, and MYB mRNA levels were significantly downregulated by PL, but SOX4 and XBP levels were increased by PL. Intriguingly, PL also increased the expression of p21 in B-ALL cells through a p53-independent mechanism. Given that these TFs and their target genes play critical roles in a variety of hematological malignancies, our findings provide a strong preclinical rationale for considering PL as a new therapeutic agent for the treatment of B-cell malignancies, including B-ALL and GC-resistant B-ALL

Piperlongumine inhibits the proliferation and survival of B-cell acute lymphoblastic leukemia cell lines irrespective of glucocorticoid resistance

Energy Technology Data Exchange (ETDEWEB)

Han, Seong-Su, E-mail: seong-su-han@uiowa.edu [Division of Pediatric Hematology-Oncology, University of Iowa Carver College of Medicine, Iowa City, IA (United States); Han, Sangwoo [Health and Human Physiology, University of Iowa Carver College of Medicine, Iowa City, IA (United States); Kamberos, Natalie L. [Division of Pediatric Hematology-Oncology, University of Iowa Carver College of Medicine, Iowa City, IA (United States)

2014-09-26

Highlights: • PL inhibits the proliferation of B-ALL cell lines irrespective of GC-resistance. • PL selectively kills B-ALL cells by increasing ROS, but not normal counterpart. • PL does not sensitize majority of B-ALL cells to DEX. • PL represses the network of constitutively activated TFs and modulates their target genes. • PL may serve as a new therapeutic molecule for GC-resistant B-ALL. - Abstract: Piperlongumine (PL), a pepper plant alkaloid from Piper longum, has anti-inflammatory and anti-cancer properties. PL selectively kills both solid and hematologic cancer cells, but not normal counterparts. Here we evaluated the effect of PL on the proliferation and survival of B-cell acute lymphoblastic leukemia (B-ALL), including glucocorticoid (GC)-resistant B-ALL. Regardless of GC-resistance, PL inhibited the proliferation of all B-ALL cell lines, but not normal B cells, in a dose- and time-dependent manner and induced apoptosis via elevation of ROS. Interestingly, PL did not sensitize most of B-ALL cell lines to dexamethasone (DEX). Only UoC-B1 exhibited a weak synergistic effect between PL and DEX. All B-ALL cell lines tested exhibited constitutive activation of multiple transcription factors (TFs), including AP-1, MYC, NF-κB, SP1, STAT1, STAT3, STAT6 and YY1. Treatment of the B-ALL cells with PL significantly downregulated these TFs and modulated their target genes. While activation of AURKB, BIRC5, E2F1, and MYB mRNA levels were significantly downregulated by PL, but SOX4 and XBP levels were increased by PL. Intriguingly, PL also increased the expression of p21 in B-ALL cells through a p53-independent mechanism. Given that these TFs and their target genes play critical roles in a variety of hematological malignancies, our findings provide a strong preclinical rationale for considering PL as a new therapeutic agent for the treatment of B-cell malignancies, including B-ALL and GC-resistant B-ALL.

Thermodynamics of the tetragonal to monoclinic phase transformation in constrained zirconia microcrystals

International Nuclear Information System (INIS)

Garvie, R.C.; Swain, M.V.

1985-01-01

End-point thermodynamic analyses were made of the tetragonal to monoclinic transformation (t -> m) occurring in ZrO 2 precipitates in a Ca-PSZ alloy and particles in Al 2 O 3 -ZrO 2 composites. Calculated plots of the reciprocal critical size for transformation temperature were in excellent agreement with experiment data for both systems. Contributions to the total free energy change included bulk chemical, dilatational and residual shear strain energies and also interfacial energies. The latter term consisted of contributions from the change in the chemical surface free energy, the presence of twin boundaries in the precipitate (particle) - matrix interfacial energy. The major impediment to the transformation was the shear strain energy which could not be reduced sufficiently by twinning alone. The t -> m reaction proceeded spontaneously when the energy barrier was reduced by the response of the particle - matrix interface. The response comprised loss of coherency and grain boundary microcracking for the Ca/PSZ and Al 2 O 3 -ZrO 2 alloys, respectively. These results are in accord with recent suggestions that either a stress-free strain or a free surface is a necessary condition for the initiation of a martensitic transformation. (author)

Aplicação do diagrama T-S estatístico: volumétrico à análise das massas de água da plataforma continental do Rio Grande do Sul The statistical volumetric T-S diagram applied to the analysis of water masses of Rio Grande do Sul continental shelf

Directory of Open Access Journals (Sweden)

Luiz Bruner de Miranda

1979-06-01

Full Text Available The general characteristics of the seasonal variation of the thermohaline properties of the continental shelf water off Rio Grande do Sul, under non-conservative and quasi-synoptic conditions were analysed. The method applied - volumetric statistical T-S analysis allows the computation of the water masses budget from the knowledge of their temperature and salinity ranges. The data of 194 hydrographic stations from six oceanographic cruises between April 1968 and March 1969, were used. Water of Tropical and Subtropical origin (47,5% and 64% of the total volume during the winter and summer, respectively was always present during the observation period. Subantarctic water has its maximum and minimum influences during the winter (15% and summer (<3%, respectively. The average minimum and maximum temperature and salinity values of the water masses in the investigated region were observed in June (16,85ºC and 34,72‰, December (35,58‰ and March (20,82ºC.

TsAg5, a Taenia solium cysticercus protein with a marginal trypsin-like activity in the diagnosis of human neurocysticercosis.

Science.gov (United States)

Rueda, Analiz; Sifuentes, Cecilia; Gilman, Robert H; Gutiérrez, Andrés H; Piña, Ruby; Chile, Nancy; Carrasco, Sebastián; Larson, Sandra; Mayta, Holger; Verástegui, Manuela; Rodriguez, Silvia; Gutiérrez-Correa, Marcel; García, Héctor H; Sheen, Patricia; Zimic, Mirko

2011-12-01

Neurocysticercosis is an endemic parasitic disease caused by Taenia solium larva. Although the mechanism of infection is not completely understood, it is likely driven by proteolytic activity that degrades the intestinal wall to facilitate oncosphere penetration and further infection. We analyzed the publicly available T. solium EST/DNA library and identified two contigs comprising a full-length cDNA fragment very similar to Echinococcus granulosus Ag5 protein. The T. solium cDNA sequence included a proteolytic trypsin-like-domain in the C-terminal region, and a thrombospondin type-1 adherence-domain in the N-terminal region. Both the trypsin-like and adherence domains were expressed independently as recombinant proteins in bacterial systems. TsAg5 showed marginal trypsin-like activity and high sequence similarity to Ag5. The purified antigens were tested in a Western immunoblot assay to diagnose human neurocysticercosis. The sensitivity of the trypsin-like-domain was 96.36% in patients infected with extraparenchymal cysts, 75.44% in patients infected with multiple cysts, and 39.62% in patients with a single cyst. Specificity was 76.70%. The thrombospondin type-1 adherence-domain was not specific for neurocysticercosis. Copyright © 2011 Elsevier B.V. All rights reserved.

Interaction of ozone with plastic and metallic materials in a dynamic flow system

Energy Technology Data Exchange (ETDEWEB)

Altshuller, A P; Wartburg, A F

1961-01-01

The loss of ozone in the p.p.h.m. range after passing through or over various plastic and metallic substances has been investigated. The materials used include Teflon, glass, stainless steel, aluminium, polyethylene and polyvinyl tubing, Mylar film, and aluminium foil. Unused Teflon passes ozone without loss. Glass tubing, after a short exposure to ozone, passes ozone without loss. Stainless steel tubing, aluminum tubing or foil and Mylar film must be exposed to ozone in the p.p.h.m. range for several hours before 90% or more of the ozone initially present can be passed through or over these materials. More rapid conditioning to ozone can be achieved by several five to fifteen-minute exposures to about 10 p.p.m. of ozone. Polyethylene and Nalgon tubing even after many hours of exposure to ozone will pass only 75 to 80% of the ozone initially present in the gas stream. Some types of polyvinyl tubing are unsatisfactory for use with ozone irrespective of the amount of exposure to ozone. Flowrates below 1000 c/sup 3//min. will increase losses of ozone. Except for Teflon and glass, materials should not be used in ozone analysis under any circumstances at low flowrates until they are thoroughly conditioned. Results obtained with stainless steel, aluminium and polyethylene indicate that conditioning to ozone once obtained will persist for at least two weeks.

Les coûts subjectifs de l’enquête ethnographique

Directory of Open Access Journals (Sweden)

Bénédicte Havard Duclos

2007-06-01

Full Text Available L’enquête ethnographique implique toujours un engagement personnel et de longue durée du chercheur, et donc une socialisation minimale au milieu enquêté. Dans une enquête dans des associations, partis ou mouvements militants, dont un des enjeux est de produire de l’adhésion et de l’« enrôlement », la sur-socialisation au milieu enquêté est d’autant plus probable que l’affinité du chercheur avec la cause défendue est préalable au démarrage de l’enquête. À travers le récit du déroulement de l’enquête et des états psycho-moraux traversés au cours de celle-ci, sont ici donnés à voir tant les conditions rendant possibles l’adhésion et la loyauté militantes que les coûts subjectifs et éthiques liés à la rupture avec le terrain, constitutive de l’acte d’écriture.The subjective costs of the ethnographic work. Investigate as activist in the association Droit Au Logement (DAL at the end of 1990sField research always implies the personal and long-term commitment of the researcher, and thus a minimal socialization in the world investigated. In a research in activist movement, which goal is to produce commitment, these socialization can be very strong, especially when the researcher was still an activist in the starting up of the field work. Through the telling the story of progress of the research and psycho-moral states crossed during this one, are here given to see the conditions making possible the activist loyalty and the subjective and ethical costs connected to the break with the field, which is a necessity of the act of writing.Los costos subjetivos de la encuesta etnográfica. Investigar siendo militante en la asociación Droit Au Logement (DAL a fines de los años 1990.La encuesta etnográfica implica un compromiso personal de duración larga del investigador; lo que significa una socialización mínima del medio estudiado. Investigar en los medios asociativos, de partidos o de movimientos

Desarrollo de un sistema prototipo de control para mezclado y monitoreo del proceso de fumigación manual en plantaciones de cacao de la comuna Flor del Valle - Santo Domingo de los Tsáchilas

OpenAIRE

Molina Puma, Diego Armando

2016-01-01

Through developing this project a prototype control system for the benefit in the process of manual spraying cocoa plantations Flower Valley Commune of the Province of Santo Domingo de los Tsáchilas implemented. This project will help small farmers in the area to achieve dose correctly, health care, minimize the risk for contamination with agrochemicals and waste there of which affect the environment and to their environment. This prototype control system has two parts: the ...

A comparative study of green composites based on tapioca starch and celluloses

Science.gov (United States)

Owi, Wei Tieng; Lin, Ong Hui; Sam, Sung Ting; Mern, Chin Kwok; Villagracia, Al Rey; Santos, Gil Nonato C.; Akil, Hazizan Md

2017-07-01

The objective of this study was to compare the properties of green composites based on tapioca starch (TS) and celluloses isolated from empty fruit bunches (EFB) and commercial celluloses from cotton linter (supplied by Sigma). Empty fruit bunches (EFB) acted as the main source to obtain the cellulose by using a chemical approach whereas the commercial cellulose from Sigma was used as reference. The TS/cellulose composite films were prepared using cellulose in varying proportions as filler into TS matrix by a casting method. The amount of celluloses added into the tapioca starch were 5, 10, 15, 20 and 25 phr (as per dry mass of TS). The celluloses were characterized using Fourier transform infrared (FTTR) spectroscopy, X-ray diffraction (XRD) and scanning electron microscopy (SEM). While the green composite films were analyzed in terms of thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), SEM and tensile properties. FTTR analysis confirmed the removal of non-cellulosic materials such as hemicelluloses and lignin from raw EFB after the chemical treatment. XRD diffractograms revealed that the crystallinity of celluloses EFB increased from 43.1 % of raw EFB to 52.1 %. SEM images showed the fibrillar structure of cellulose isolated from EFB. The TGA and derivative thermogravimetric (DTG) curves of green composite films showed no significant effect on the thermal stability. Melting temperature of TS/cellulose EFB higher than neat TS while TS/cellulose Sigma lower than neat TS. The green composite films with 15 phr cellulose from EFB filler loading provided the best tensile properties in term of its strength and modulus. However, in term of elongation at break, the percentage elongation decreased with the increased of the amount of filler loading. SEM images of the films demonstrated a good interaction between cellulose filler and TS matrix especially with the addition of 15 phr of cellulose from EFB.

Effect of avalanche-type barrier discharge on a silver halide photographic material in the case of blocked ionic conductivity

International Nuclear Information System (INIS)

Boychenko, A. P.

2012-01-01

Imaging of avalanche-type barrier gas discharge excited by single videopulses ∼7 μs long is studied via chemical activation of an ion subsystem of microcrystals of silver halide photographic emulsions by 1-phenyl-5-mercaptotetrazole. Using “Retina” commercial X-ray film and specially fabricated photoemulsion microcrystals with effective surface and deep electron traps as an example, the selective gas-discharge sensitivity of photographic layers to applied-voltage polarity is detected. It is shown that their sensitivity to barrier discharge ignited by negative-polarity pulses (on the electrode with a photographic material) is higher than in the case of positive pulses, irrespective of the photographic material’s position in the capacitor system.

Thermodynamic analysis of the tetragonal to monoclinic transformation in a constrained zirconia microcrystal

International Nuclear Information System (INIS)

Garvie, R.C.

1985-01-01

A thermodynamic analysis was made of a simple model comprising a transforming t-ZrO 2 microcrystal of size d constrained in a matrix subjected to a hydrostatic tensile stress field. The field generated a critical size range such that a t-particle transformed if dsub(cl) < d < dsub(cu). The lower limit dsub(cl) exists because at this point the maximum energy (supplied by the applied stress) which can be taken up by the crystal is insufficient to drive the transformation. The upper limit dsub(cu) is a consequence of the microcrystal being so large that it transforms spontaneously when the material is cooled to room temperature. Using the thermodynamic (Griffith) approach and assuming that transformation toughening is due to the dilational strain energy, this mechanism accounted for about one-third of the total observed effective surface energy in a peak-aged Ca-PSZ alloy. (author)

The effect of some factors on Ms and SME in Ce-TZP ceramics

International Nuclear Information System (INIS)

Jiang, B.; Tu, J.; Hsu, T.Y.; Qi, X.; Zheng, X.; Zhong, J.

1992-01-01

As known to all, shape memory behaviour has been observed in a variety of metallic alloys. This phenomenon, however, is not only observed in that field but also in other materials recently, such as in polymers, intermetallic compounds and ceramics, especially in zirconia ceramics. Swain observed the shape recovery of a bent magnesia-partially-stabilized zirconia (Mg-PSZ) bar upon heating above a certain temperature. The maximum deflection which was nearly completely recovered on heating is about 300 μm. Chen et al., investigated the pseudoelasticity and shape memory effect (SME) in ceria-stabilized tetragonal zirconia polycrystals (Ce-TZP) containing 12 mol% CeO 2 . Wang et al., also observed the SME in Ce-TZP containing 10 mol% CeO 2 . In this paper, the authors would like to introduce some of results conducted recently in our group on SME in Ce-TZP ceramics

Degradación de barreras térmicas por sales fundidas

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Utrilla, M. V.

2008-04-01

Full Text Available Thermal barrier coatings (TBC are frequently used to provide thermal insulation to metallic components. The material used in this investigation comprises a ceramic top layer, ZrO2 8Y2O3 (Y-PSZ, and an overlay coating, Ni22Cr10Al1Y, air plasma sprayed on to a nickel base alloy Inconel 600 substrate. Yttria stabilizes the cubic phase zirconia, but it can react with S, V and Na contaminants contained in many low-quality industrial fuels. A decrease in the yttria content promotes the transformation to monoclinic ZrO2. The materials were subjected to an isothermal air furnace test under 40% Na2SO4 - 60% V2O5 mixtures at 800 ºC for 48 and 144h. The degradation of the coating was analyzed by electrochemical impedance spectroscopy (EIS. The microstructure was characterized by enviromental scanning electron microscopy (ESEM, X-ray microanalysis (EDX and x ray diffracction (XRD.

Las barreras térmicas son sistemas multicapa que se aplican a sustratos metálicos para mejorar su resistencia a la temperatura. El material utilizado en el trabajo es un sustrato base níquel (Inconel 600 con recubrimiento multicapa de NiCrAlY y ZrO2 parcialmente estabilizada con Y2O3 (Y-PSZ depositado por plasma atmosférico. La presencia de contaminantes, como S, V o Na presentes en combustibles de baja calidad, puede dar lugar a reacciones con este óxido estabilizador de la circona (Y2O3, originando una desestabilización estructural de la circona por disminución del contenido en itria. En esta comunicación se ha realizado un estudio sistemático de la degradación del material frente a determinados agentes corrosivos a elevada temperatura. Sobre la superficie de las muestras se añadieron mezclas de 40% Na2SO4-60% V2O5 y se trataron isotérmicamente a 800 ºC durante 48 y 144 horas. Finalmente, se evaluó la modificación de las propiedades por efecto de los agentes agresivos. Mediante la técnica de espectroscopía de impedancia electroquímica (EIS se estimó la