WorldWideScience

Sample records for psychoanalytischer verlag founded

  1. Rezension von: Sebastian Winter: Geschlechter- und Sexualitätsentwürfe in der SS-Zeitung ‚Das Schwarze Korps‘. Eine psychoanalytisch-sozialpsychologische Studie. Gießen: Psychosozial-Verlag 2013.

    Directory of Open Access Journals (Sweden)

    Heinz-Jürgen Voß

    2013-10-01

    Full Text Available Sebastian Winter unternimmt in seiner Studie den Versuch, geschichtswissenschaftliche und psychoanalytisch-sozialpsychologische Perspektiven für die Auseinandersetzung mit den Geschlechter- und Sexualitätsvorstellungen der Nazi-Zeit produktiv zusammenzuführen. Dafür gibt er beachtenswerte Anregungen, die weitere Forschungsarbeiten inspirieren sollten. Die ertragreiche Lektüre wird allerdings dadurch erschwert, dass der bisherige geschichtswissenschaftliche Forschungsstand sehr knapp und zuweilen erst spät – noch am Ende des Buches – vorgestellt wird.

  2. Das chinesische Selbst. Die psychoanalytisch orientierte Psychotherapie in der Volksrepublik China

    Directory of Open Access Journals (Sweden)

    Antje Haag

    2015-12-01

    Full Text Available Vor dem Hintergrund ihrer 20-jährigen Erfahrung als Dozentin für psychoanalytisch orientierte Psychotherapie in der Volksrepublik China diskutiert die Autorin Fragen, die im Zusammenhang mit dem Transfer einer am Individuum orientierten Therapiemethode in ein Land mit einer kollektivistisch-konfuzianischen Tradition gestellt werden können. Zunächst werden die kulturbedingt unterschiedlichen Konstruktionen des Selbst beschrieben, die einen besonderen Kommunikationsstil und – im Fall Chinas – eine ausgeprägtere Schamanfälligkeit implizieren. Psychoanalytische Grundannahmen wie Abstinenz, therapeutische Ich-Spaltung, Introspektionsfähigkeit und Übertragung können, ebenso wie das traditionell konfuzianische Harmoniestreben, auf kulturell immanente Probleme treffen. Eine spezifische Abwehrformation, die «Ah-QMentalität», wird vorgestellt und im Sinne eines daoistisch fundierten Denkens verstanden. Schliesslich wird diskutiert, ob bei psychoanalytisch orientierter Behandlungstechnik in weniger individualisierten Kulturen Modifikationen sinnvoll sind.

  3. Anmerkungen zu Goethe : eine psychoanalytische Untersuchung über Goethe als Repräsentant deutscher Kultur

    NARCIS (Netherlands)

    Kaus, Rainer J.

    1994-01-01

    De oorspronkelijke aanleiding tot dit onderzoek was de invloedrijke psychoanalytische studie in twee delen van K.R. Eissler, Goethe: A Psychoanalytic Study 1775-1786, oorspronkelijk verschenen in de Verenigde Staten (Detroit: Wayne State UP, 1963), in Duitse vertaling bij uitgeverij Stroemfeld/Roter

  4. Anmerkungen zu Goethe: eine psychoanalytische Untersuchung über Goethe als Repräsentant deutscher Kultur

    OpenAIRE

    Kaus, Rainer J.

    1994-01-01

    De oorspronkelijke aanleiding tot dit onderzoek was de invloedrijke psychoanalytische studie in twee delen van K.R. Eissler, Goethe: A Psychoanalytic Study 1775-1786, oorspronkelijk verschenen in de Verenigde Staten (Detroit: Wayne State UP, 1963), in Duitse vertaling bij uitgeverij Stroemfeld/Roter Stern (Basel 1983/5) en recentelijk in een pocketboek-uitgave bij uitgeverij dtv (München 1987). Eisslers voornaamste stelling in diens biografische studie van een periode uit Goethes leven, dat G...

  5. Julia Kristeva: Das weibliche Genie – Melanie Klein. Gießen: Psychosozial-Verlag 2008

    Directory of Open Access Journals (Sweden)

    Lilli Gast

    2009-07-01

    Full Text Available Julia Kristeva widmet sich im zweiten Teil ihrer Trilogie über das weibliche Genie dem Leben und Werk von Melanie Klein, die mit ihren Arbeiten über die früheste Verfasstheit des Psychischen das psychoanalytische Denken für die Psychosen und den Wahn aufschloss und die Rolle des Mütterlichen im psychoanalytischen Diskurs neu definierte. In ihrer Auseinandersetzung mit Klein gelingt Kristeva nicht nur eine ausgesprochen gelungene Einführung in Kleins Denken, sondern auch eine Analyse weiblicher Intellektualität im 20. Jahrhundert. Zudem werden die Schnittstellen im Denken Kleins und Kristevas sichtbar.Julia Kristeva devotes this second installment of her trilogy on feminine genius to the life and work of Melanie Klein. Klein’s work on the early state of the psyche opened psychoanalytical thinking to psychoses, delusion, and the redefined the role of the motherly in psychoanalytical discourse. In her discussion of Klein, Kristeva provides not only a markedly insightful introduction to Klein’s thinking, but also an analysis of female intellectuality in the 20th century. Moreover, the reader clearly sees the interconnections between Klein and Kristeva’s thinking.

  6. Springer-Verlag history of a scientific publishing house

    CERN Document Server

    Sarkowski, Heinz

    1996-01-01

    This book describes the fortunes and activities of one of the few specialist publishing houses still in the hands of the same family that established it over 150 years ago and with it gives a portrayal of those members who directed it. In doing so it covers a period of momentous historical events that directly and indirectly shaped the firm's actions and achievements. But this volume tells not only, in word and picture, the story of Springer-Verlag but also, interwoven with it, the story of publishing in Germany over the span of a hundred years. The text, densely packed with carefully researched facts and figures, is illuminated and supplemented by many illustrations whose captions, together with the author's notes, contain a wealth of important and interesting information. A second volume contains the history of the publishing house from 1945 to 1992.

  7. Approaching the 'As Found'

    DEFF Research Database (Denmark)

    Braae, Ellen Marie

    2017-01-01

    The twentieth century was obsessed with novelty. It was obsessed with the idea of newness, with all that which had never been seen before—regarding novelty as a direct reflection of humanity's continuous development. This attention toward novelty goes hand in hand with the idea of progress, which......' and ‘edit' the ‘as found' has to a certain degree always been the point of departure for landscape architecture. Yet these more fundamental shifts in premises that goes with the limited resources are so materially and culturally profound that they deeply affect the theories and methods of landscape...

  8. 32 New Exoplanets Found

    Science.gov (United States)

    2009-10-01

    , which detects small changes in the radial velocity of a star as it wobbles slightly under the gentle gravitational pull from an (unseen) exoplanet, has been most prolific method in the search for exoplanets. In return for building the instrument, the HARPS consortium was granted 100 observing nights per year during a five-year period to carry out one of the most ambitious systematic searches for exoplanets so far implemented worldwide by repeatedly measuring the radial velocities of hundreds of stars that may harbour planetary systems. The programme soon proved very successful. Using HARPS, Mayor's team discovered - among others - in 2004, the first super-Earth (around µ Ara; in 2006, the trio of Neptunes around HD 69830; in 2007, Gliese 581d, the first super Earth in the habitable zone of a small star (eso0722); and in 2009, the lightest exoplanet so far detected around a normal star, Gliese 581e (eso0915). More recently, they found a potentially lava-covered world, with density similar to that of the Earth's (eso0933). "These observations have given astronomers a great insight into the diversity of planetary systems and help us understand how they can form," says team member Nuno Santos. The HARPS consortium was very careful in their selection of targets, with several sub-programmes aimed at looking for planets around solar-like stars, low-mass dwarf stars, or stars with a lower metal content than the Sun. The number of exoplanets known around low-mass stars - so-called M dwarfs - has also dramatically increased, including a handful of super Earths and a few giant planets challenging planetary formation theory. "By targeting M dwarfs and harnessing the precision of HARPS we have been able to search for exoplanets in the mass and temperature regime of super-Earths, some even close to or inside the habitable zone around the star," says co-author Xavier Bonfils. The team found three candidate exoplanets around stars that are metal-deficient. Such stars are thought to be

  9. [The founding of Zemun Hospital].

    Science.gov (United States)

    Milanović, Jasmina; Milenković, Sanja; Pavlović, Momcilo; Stojanović, Dragos

    2014-01-01

    This year Zemun Hospital--Clinical Hospital Center Zemun celebrates 230th anniversary of continuous work, thus becoming the oldest medical facility in Serbia.The exact date of the hospital founding has been often questioned in history. Various dates appeared in the literature, but the most frequent one was 25th of February 1784. Until now, the document which confirms this has never been published. This article represents the first official publication of the document which confirms that Zemun Hospital was indeed founded on this date. The first hospitals started emerging in Zemun when the town became a part of the Habsburg Monarchy. The first sanitary facility ever formed was the"Kontumac"--a quarantine established in 1730. Soon after, two more confessional hospitals were opened.The Serbian (Orthodox) Hospital was founded before 1769, whereas the German (Catholic) Hospital started working in 1758. Both hospitals were financed, amongst others, by the Town Hall--the Magistrate. In order to improve efficiency of these hospitals, a decision was made to merge them into a single City Hospital. It was founded on 25th February 1784, when the General Command ordered the Magistrate of Zemun to merge the financess of all existing hospitals and initiate the construction of a new building. Although financially united, the hospitals continued working in separate buildings over a certain period of time.The final, physical merging of these hospitals was completed in 1795.

  10. Found in Translation, Chapter L

    OpenAIRE

    Frampier, Marie

    2012-01-01

    Chapter D, chapter H and chapter L sont les trois premiers tomes de l’exposition bruxelloise et luxembourgeoise, intitulée Found in Translation, présentée en dernière instance au Casino Luxembourg (oct. 2011-janv. 2012). La traduction est ici à appréhender non pas en son sens linguistique mais comme le mouvement d’un médium, d’une histoire, d’un langage vers un autre. La translation est processuelle ; la traduction devient un passage de témoin, une transmission d’expériences. Le catalogue s’o...

  11. Lightweight Double Neutron Star Found

    Science.gov (United States)

    Kohler, Susanna

    2018-02-01

    More than forty years after the first discovery of a double neutron star, we still havent found many others but a new survey is working to change that.The Hunt for PairsThe observed shift in the Hulse-Taylor binarys orbital period over time as it loses energy to gravitational-wave emission. [Weisberg Taylor, 2004]In 1974, Russell Hulse and Joseph Taylor discovered the first double neutron star: two compact objects locked in a close orbit about each other. Hulse and Taylors measurements of this binarys decaying orbit over subsequent years led to a Nobel prize and the first clear evidence of gravitational waves carrying energy and angular momentum away from massive binaries.Forty years later, we have since confirmed the existence of gravitational waves directly with the Laser Interferometer Gravitational-Wave Observatory (LIGO). Nonetheless, finding and studying pre-merger neutron-star binaries remains a top priority. Observing such systems before they merge reveals crucial information about late-stage stellar evolution, binary interactions, and the types of gravitational-wave signals we expect to find with current and future observatories.Since the Hulse-Taylor binary, weve found a total of 16 additional double neutron-star systems which represents only a tiny fraction of the more than 2,600 pulsars currently known. Recently, however, a large number of pulsar surveys are turning their eyes toward the sky, with a focus on finding more double neutron stars and at least one of them has had success.The pulse profile for PSR J1411+2551 at 327 MHz. [Martinez et al. 2017]A Low-Mass DoubleConducted with the 1,000-foot Arecibo radio telescope in Puerto Rico, the Arecibo 327 MHz Drift Pulsar Survey has enabled the recent discovery of dozens of pulsars and transients. Among them, as reported by Jose Martinez (Max Planck Institute for Radio Astronomy) and coauthors in a recent publication, is PSR J1411+2551: a new double neutron star with one of the lowest masses ever measured

  12. Het Narcisme. De psychoanalytische theorie en haar lotgevallen

    NARCIS (Netherlands)

    Vandermeersch, P.M.G.P.

    1982-01-01

    Inspired by the book of Chr. Lasch, The Culture of Narcissism (1978), the history of the concept is investigated. Narcissism is introduced by Freud in order to designate the peculiar psychological structure preserving a human being from the danger of psychosis. According to Freud narcissism and

  13. First supernova companion star found

    Science.gov (United States)

    2004-01-01

    ). These two mighty galaxies in the Plough (Ursa Major) belong to some of the most famous and beloved galaxies known to amateur astronomers. This may be one of the reasons that Supernova 1993J was discovered by the Spanish amateur astronomer Francisco Garcia Diaz and not a professional astronomer. The violent star-forming activity in the neighbouring Messier 82 gives rise to a strong galactic wind that is spewing knotty filaments of hydrogen and nitrogen gas (seen in red) out of its centre. Supernovae are some of the most significant sources of chemical elements in the Universe, and they are at the heart of our understanding of the evolution of galaxies. Supernovae are some of the most violent events in the Universe. For many years astronomers have thought that they occur in either solitary massive stars (Type II supernovae) or in a binary system where the companion star plays an important role (Type I supernovae). However no one has been able to observe any such companion star. It has even been speculated that the companion stars might not survive the actual explosion... The second brightest supernova discovered in modern times, SN 1993J, was found in the beautiful spiral galaxy M81 on 28 March 1993. From archival images of this galaxy taken before the explosion, a red supergiant was identified as the mother star in 1993 - only the second time astronomers have actually seen the progenitor of a supernova explosion (the first was SN 1987A, the supernova that exploded in 1987 in our neighbouring galaxy, the Large Magellanic Cloud). Initially rather ordinary, SN 1993J began to puzzle astronomers as its ejecta seemed too rich in the chemical element helium and instead of fading normally it showed a bizarre sharp increase in brightness. The astronomers realised that a normal red supergiant alone could not have given rise to such a weird supernova. It was suggested that the red supergiant orbited a companion star that had shredded its outer layers just before the explosion. Ten

  14. Ariane Bürgin: Endliches Subjekt. München: Wilhelm Fink Verlag 2008

    Directory of Open Access Journals (Sweden)

    Stefan Müller

    2009-07-01

    Full Text Available Die Idee der Gleichheit bei den beiden Klassikern der politischen Philosophie Hobbes und Rousseau soll vor dem Hintergrund der neueren feministischen Debatten um Gleichheit und Differenz betrachtet werden. Doch die Ausführungen verlaufen stark entlang der bloßen Wiedergabe der Originalliteratur und deren Rezeptionsgeschichte – unter besonderer Berücksichtigung von Lacan. Die vielfältigen und großen Diskussionen in der feministischen Theorie finden dabei viel zu wenig Beachtung.The idea of equality explored in the writings of the classic political philosophers Hobbes and Rousseau should be examined in the context of more recent feminist debates on equality and difference. However, the study produces a mere repetition of the primary literature and its reception history, while placing a special focus on Lacan. The diverse and broad discussions found in feminist theory are not given adequate consideration.

  15. Aby Warburg, Images and Exhibitions. Aby Warburg, Bilderreihen und Ausstellungen edited by Uwe Fleckner and Isabelle Woldt, Akademie Verlag, 2012

    Directory of Open Access Journals (Sweden)

    Matthew Rampley

    2012-12-01

    Full Text Available This article reviews the latest volume in the collected works of Aby Warburg published by Akademie Verlag. The volume consists of exhibitions and plates of images Warburg compiled to illustrate lectures in the period between 1925-1929. The review focuses on two key issues raised by the publication: the light it casts on the Mnemosyne Atlas Warburg was working on at the same time, and, in particular, how it helps shape perceptions of the broader intellectual direction of Warburg's thinking in the final half decade of his life.

  16. Zbigniew Wozniak, The Elderly in Social Policy. Towards a New Architecture of Gerontological Programmes (Development in Humanities, Volume 4, Lit Verlag, 2013

    Directory of Open Access Journals (Sweden)

    Dianne Campbell

    2015-03-01

    Full Text Available A review of the following book: Zbigniew Wozniak, The Elderly in Social Policy. Towards a New Architecture of Gerontological Programmes (Development in Humanities, Volume 4, Lit Verlag, 2013

  17. The Found World of American Political Theory.

    Science.gov (United States)

    DeMaio, Gerald

    1981-01-01

    Discusses recent trends in the development of American political theory and reviews four themes found in current anthologies and monographs which can be used to supplement college political theory courses. The themes include the founding of America, the Lincoln literature, religion, and the neoconservative phenomenon. (AM)

  18. Lost and Found Cafe Coleraine Menu 2017

    OpenAIRE

    Lost and Found Cafe

    2017-01-01

    LOST & FOUND IS AN INDEPENDENT CAFE SITUATED ON THE BEAUTIFUL NORTH COAST OF IRELAND. AT THE CORE OF LOST & FOUND IS THE DESIRE TO CELEBRATE THE CRAFT OF SIMPLE, DELICIOUS COFFEE AND FOOD IN AN INSPIRING AND WELCOMING PLACE. WE LOOK FORWARD TO SERVING YOU. http://arrow.dit.ie/menus21c/1383/thumbnail.jpg

  19. The Founding of the Learning Communities Association

    Science.gov (United States)

    Huerta, Juan Carlos

    2017-01-01

    Learning communities have reached the point in their growth that we now need a professional association to allow for more opportunities for participation in advancing learning communities. This is the story of the founding of the new Learning Communities Association.

  20. 75 FR 7628 - Founding Fathers Advisory Committee

    Science.gov (United States)

    2010-02-22

    ... Committee Act, 5 U.S.C. Appendix 2. SUMMARY: The Archivist of the United States has determined that the... Archivist of the United States on the progress of the Founding Fathers editorial projects funded by the... includes, but is not limited to, advising and making recommendations to the Archivist on issues related to...

  1. Establishment probability in newly founded populations

    Directory of Open Access Journals (Sweden)

    Gusset Markus

    2012-06-01

    Full Text Available Abstract Background Establishment success in newly founded populations relies on reaching the established phase, which is defined by characteristic fluctuations of the population’s state variables. Stochastic population models can be used to quantify the establishment probability of newly founded populations; however, so far no simple but robust method for doing so existed. To determine a critical initial number of individuals that need to be released to reach the established phase, we used a novel application of the “Wissel plot”, where –ln(1 – P0(t is plotted against time t. This plot is based on the equation P0t=1–c1e–ω1t, which relates the probability of extinction by time t, P0(t, to two constants: c1 describes the probability of a newly founded population to reach the established phase, whereas ω1 describes the population’s probability of extinction per short time interval once established. Results For illustration, we applied the method to a previously developed stochastic population model of the endangered African wild dog (Lycaon pictus. A newly founded population reaches the established phase if the intercept of the (extrapolated linear parts of the “Wissel plot” with the y-axis, which is –ln(c1, is negative. For wild dogs in our model, this is the case if a critical initial number of four packs, consisting of eight individuals each, are released. Conclusions The method we present to quantify the establishment probability of newly founded populations is generic and inferences thus are transferable to other systems across the field of conservation biology. In contrast to other methods, our approach disaggregates the components of a population’s viability by distinguishing establishment from persistence.

  2. Bioactive Compounds Found in Brazilian Cerrado Fruits.

    Science.gov (United States)

    Bailão, Elisa Flávia Luiz Cardoso; Devilla, Ivano Alessandro; da Conceição, Edemilson Cardoso; Borges, Leonardo Luiz

    2015-10-09

    Functional foods include any natural product that presents health-promoting effects, thereby reducing the risk of chronic diseases. Cerrado fruits are considered a source of bioactive substances, mainly phenolic compounds, making them important functional foods. Despite this, the losses of natural vegetation in the Cerrado are progressive. Hence, the knowledge propagation about the importance of the species found in Cerrado could contribute to the preservation of this biome. This review provides information about Cerrado fruits and highlights the structures and pharmacologic potential of functional compounds found in these fruits. Compounds detected in Caryocar brasiliense Camb. (pequi), Dipteryx alata Vog. (baru), Eugenia dysenterica DC. (cagaita), Eugenia uniflora L. (pitanga), Genipa americana L. (jenipapo), Hancornia speciosa Gomes (mangaba), Mauritia flexuosa L.f. (buriti), Myrciaria cauliflora (DC) Berg (jabuticaba), Psidium guajava L. (goiaba), Psidium spp. (araçá), Solanum lycocarpum St. Hill (lobeira), Spondias mombin L. (cajá), Annona crassiflora Mart. (araticum), among others are reported here.

  3. FOUNDING OF THE DISTRICT HOSPITAL IN NIS

    Directory of Open Access Journals (Sweden)

    Misa Zivic

    2007-01-01

    Full Text Available After the liberation of Nis from the Turks which took place on January 11th, 1878, there were two military hospitals: one was next to The Skull Tower and the other on the road to Leskovac and there was Islahana the civil institution which was not the forerunner of the district hospital in Nis. At first, they founded the military hospital in Nis in 1878 and then they founded The District Hospital on July 17th in 1881. The first director of the District hospital was Anton Zajicek. He is also the first graduated medical doctor in Nis. The District Hospital was situated on the left bank of the Nisava river in a private house.

  4. Bioactive Compounds Found in Brazilian Cerrado Fruits

    Directory of Open Access Journals (Sweden)

    Elisa Flávia Luiz Cardoso Bailão

    2015-10-01

    Full Text Available Functional foods include any natural product that presents health-promoting effects, thereby reducing the risk of chronic diseases. Cerrado fruits are considered a source of bioactive substances, mainly phenolic compounds, making them important functional foods. Despite this, the losses of natural vegetation in the Cerrado are progressive. Hence, the knowledge propagation about the importance of the species found in Cerrado could contribute to the preservation of this biome. This review provides information about Cerrado fruits and highlights the structures and pharmacologic potential of functional compounds found in these fruits. Compounds detected in Caryocar brasiliense Camb. (pequi, Dipteryx alata Vog. (baru, Eugenia dysenterica DC. (cagaita, Eugenia uniflora L. (pitanga, Genipa americana L. (jenipapo, Hancornia speciosa Gomes (mangaba, Mauritia flexuosa L.f. (buriti, Myrciaria cauliflora (DC Berg (jabuticaba, Psidium guajava L. (goiaba, Psidium spp. (araçá, Solanum lycocarpum St. Hill (lobeira, Spondias mombin L. (cajá, Annona crassiflora Mart. (araticum, among others are reported here.

  5. Bioactive Compounds Found in Brazilian Cerrado Fruits

    Science.gov (United States)

    Bailão, Elisa Flávia Luiz Cardoso; Devilla, Ivano Alessandro; da Conceição, Edemilson Cardoso; Borges, Leonardo Luiz

    2015-01-01

    Functional foods include any natural product that presents health-promoting effects, thereby reducing the risk of chronic diseases. Cerrado fruits are considered a source of bioactive substances, mainly phenolic compounds, making them important functional foods. Despite this, the losses of natural vegetation in the Cerrado are progressive. Hence, the knowledge propagation about the importance of the species found in Cerrado could contribute to the preservation of this biome. This review provides information about Cerrado fruits and highlights the structures and pharmacologic potential of functional compounds found in these fruits. Compounds detected in Caryocar brasiliense Camb. (pequi), Dipteryx alata Vog. (baru), Eugenia dysenterica DC. (cagaita), Eugenia uniflora L. (pitanga), Genipa americana L. (jenipapo), Hancornia speciosa Gomes (mangaba), Mauritia flexuosa L.f. (buriti), Myrciaria cauliflora (DC) Berg (jabuticaba), Psidium guajava L. (goiaba), Psidium spp. (araçá), Solanum lycocarpum St. Hill (lobeira), Spondias mombin L. (cajá), Annona crassiflora Mart. (araticum), among others are reported here. PMID:26473827

  6. Βιβλιοκρισία:P. SCHREINER-E. VOGT(eds., Karl Krumbacher. Leben und Werk, München, Verlag der Bayerischen Akademie der Wissenschaften in Kommission beim Verlag C. H. Beck, München 2011

    Directory of Open Access Journals (Sweden)

    Walter PUCHNER

    2013-04-01

    Full Text Available Βιβλιοκρισία: P. Schreiner-E. Vogt (eds., Karl Krumbacher. Leben und Werk, München, Verlag der Bayerischen Akademie der Wissenschaften in Kommission beim Verlag C. H. Beck, München 2011 (Bayerische Akademie der Wissenschaften, Philosophisch-historische Klasse, Sitzungsberichte, Jahrgang 2011, Heft 4, σελ. 147, 5 εικ., ΙSBN 978 3 7696 1569 0.

  7. Antitumor Phenylpropanoids Found in Essential Oils

    Directory of Open Access Journals (Sweden)

    Adriana Andrade Carvalho

    2015-01-01

    Full Text Available The search for new bioactive substances with anticancer activity and the understanding of their mechanisms of action are high-priorities in the research effort toward more effective treatments for cancer. The phenylpropanoids are natural products found in many aromatic and medicinal plants, food, and essential oils. They exhibit various pharmacological activities and have applications in the pharmaceutical industry. In this review, the anticancer potential of 17 phenylpropanoids and derivatives from essential oils is discussed. Chemical structures, experimental report, and mechanisms of action of bioactive substances are presented.

  8. Commentary on Malone: Who Founded Behaviorism?

    Science.gov (United States)

    Reese, Hayne W

    2015-05-01

    Malone (The Behavior Analyst, 37, 1-12 2014) argued that the emergence of behaviorism was inevitable with or without Watson's participation, mainly because protobehavioral ideas and dissatisfaction with classical structuralism were already widespread. However, the first premise is questionable because many of the ideas Malone cited were consistent with structuralism rather than behaviorism, and even if both premises were true they would not make the emergence of behaviorism-or anything else-inevitable. Historical evidence for inevitability is always retrospective and therefore always allows the logical fallacy of "after this, therefore because of this." In the relevant real world Watson existed, he was a psychologist, he was the first to publish an article that described a "behaviorism," and he promoted his behaviorism in later works. Stories about what would have happened without Watson's participation are therefore counterfactual and this lack of historicity makes the stories fictional rather than scientific. In the real world, Watson founded behaviorism.

  9. Silica-Rich Soil Found by Spirit

    Science.gov (United States)

    2007-01-01

    NASA's Mars Exploration Rover Spirit has found a patch of bright-toned soil so rich in silica that scientists propose water must have been involved in concentrating it. The silica-rich patch, informally named 'Gertrude Weise' after a player in the All-American Girls Professional Baseball League, was exposed when Spirit drove over it during the 1,150th Martian day, or sol, of Spirit's Mars surface mission (March 29, 2007). One of Spirit's six wheels no longer rotates, so it leaves a deep track as it drags through soil. Most patches of disturbed, bright soil that Spirit had investigated previously are rich in sulfur, but this one has very little sulfur and is about 90 percent silica. This image is a approximately true-color composite of three images taken through different filters by Spirit's panoramic camera on Sol 1,187 (May 6). The track of disturbed soil is roughly 20 centimeters (8 inches) wide. Spirit's miniature thermal emission spectrometer, which can assess a target's mineral composition from a distance, examined the Gertrude Weise patch on Sol 1,172 (April 20). The indications it found for silica in the overturned soil prompted a decision to drive Spirit close enough to touch the soil with the alpha particle X-ray spectrometer, a chemical analyzer at the end of Spirit's robotic arm. The alpha particle X-ray spectrometer collected data about this target on sols 1,189 and 1,190 (May 8 and May 9) and produced the finding of approximately 90 percent silica. Silica is silicon dioxide. On Earth, it commonly occurs as the crystalline mineral quartz and is the main ingredient in window glass. The Martian silica at Gertrude Weise is non-crystalline, with no detectable quartz. In most cases, water is required to produce such a concentrated deposit of silica, according to members of the rover science team. One possible origin for the silica could have been interaction of soil with acidic steam produced by volcanic activity. Another could have been from water in a hot

  10. Vast Peatlands Found in the Congo Basin

    Science.gov (United States)

    Fatoyinbo, Lola

    2017-01-01

    Southeast Asias share of Earths tropical peatlands was previously put at 561, but the largest of the tropics peatland complexes might in fact lie elsewhere. On page 86, Dargie et al. combine satellite data with extensive field measurements of peat depth, carbon concentration and radiocarbon dating to produce a map of potential peat extent and carbon stocks in the Cuvette Centrale depression of the central Congo Basin. The authors propose that the Cuvette Centrale represents the worlds largest tropical peatland complex, covering 145,500 square kilometres and possibly storing about 30 petagrams of carbon (1 Pg is 1015 grams) the equivalent of 20 years of current US carbon emissions from fossil fuels. Tropical peatlands have garnered increasing attention in recent years owing to their crucial role as terrestrial organic carbon reserves and the implications of peatland loss for climate change. Thick peat soils (ranging from 30 cm to up to 30 m)3 form in areas where water-logged soils create anoxic conditions that prevent organic materials such as dead leaves and wood from fully decomposing. The largest areas of peat are in temperate regions, but large areas of forested peatlands are also found in the tropics.

  11. Did John B. Watson Really "Found" Behaviorism?

    Science.gov (United States)

    Malone, John C

    2014-05-01

    Developments culminating in the nineteenth century, along with the predictable collapse of introspective psychology, meant that the rise of behavioral psychology was inevitable. In 1913, John B. Watson was an established scientist with impeccable credentials who acted as a strong and combative promoter of a natural science approach to psychology when just such an advocate was needed. He never claimed to have founded "behavior psychology" and, despite the acclaim and criticism attending his portrayal as the original behaviorist, he was more an exemplar of a movement than a founder. Many influential writers had already characterized psychology, including so-called mental activity, as behavior, offered many applications, and rejected metaphysical dualism. Among others, William Carpenter, Alexander Bain, and (early) Sigmund Freud held views compatible with twentieth-century behaviorism. Thus, though Watson was the first to argue specifically for psychology as a natural science, behaviorism in both theory and practice had clear roots long before 1913. If behaviorism really needs a "founder," Edward Thorndike might seem more deserving, because of his great influence and promotion of an objective psychology, but he was not a true behaviorist for several important reasons. Watson deserves the fame he has received, since he first made a strong case for a natural science (behaviorist) approach and, importantly, he made people pay attention to it.

  12. Norovirus contamination found in oysters worldwide.

    Science.gov (United States)

    Cheng, Peter K C; Wong, Derek K K; Chung, Thomas W H; Lim, Wilina W L

    2005-08-01

    Noroviruses (Norwalk-like viruses) are recognized as major causes of acute gastroenteritis worldwide. Outbreaks of norovirus gastroenteritis are often associated with consumption of oysters. In this study, oysters imported into Hong Kong from 11 countries over a 3-year period were screened by RT-PCR. Overall, 53 out of 507 (10.5%) samples were positive for norovirus-RNA, and a wide variety of strains were found. Two novel genetic clusters were detected, which could indicate novel human or animal norovirus strains. However, whether these two new clusters are of human or animal origin is not known. Thirteen outbreaks, in which oysters were implicated as the source of infection were investigated: Norovirus RNA sequences could be detected in oysters from six outbreaks, but only in one outbreak the strains isolated from patients and oysters matched (>98% homology). Therefore, RT-PCR was of use in detecting norovirus contamination of oysters implicated in an outbreak, but was less useful in demonstrating an actual molecular epidemiological link with human cases. It was shown that contamination by noroviruses could be demonstrated in oysters worldwide, and therefore oysters may serve as an important vehicle for introducing novel norovirus strains. (c) 2005 Wiley-Liss, Inc.

  13. Decalcified choroidal osteoma found in the retina

    Directory of Open Access Journals (Sweden)

    Yoshikawa T

    2012-11-01

    Full Text Available Tadanobu Yoshikawa, Kanji TakahashiDepartment of Ophthalmology, Kansai Medical University, Hirakata Hospital, Osaka, JapanAbstract: Choroidal osteoma is a benign tumor of the choroid. Herein, we report a rare case of decalcified choroidal osteoma found in the retina. A 27-year-old woman presented with visual loss. Her best-corrected visual acuity was 20/50 OS. Ophthalmoscopy of the left eye revealed a yellow-white calcified region accompanied by a decalcified region of four disc diameters in size. After 6 years, spectral-domain optical coherence tomography showed a tumor projected strongly upwards from the choroid and partially through the retina with serous retinal detachment, with both a lamellar appearance and mound-like area. The calcified region became more contractive than was observed on the first visit. Conversely, the decalcified region was wider than was observed on the first visit. Her best-corrected visual acuity was 20/400 OS. Choroidal osteoma was worsened by progression of decalcification. The decalcified choroidal osteoma resulted in poor visual acuity, and projected strongly upward from the choroid and into the retina.Keywords: osteoma, decalcification, choroidal osteoma

  14. Johanna Schaffer: Ambivalenzen der Sichtbarkeit. Über die visuellen Strukturen der Anerkennung. Bielefeld: transcript Verlag 2008.

    Directory of Open Access Journals (Sweden)

    Tanja Maier

    2010-03-01

    Full Text Available Wie können minorisierte Gruppen sichtbar (gemacht werden, ohne dabei in der Art und Weise ihrer visuellen Darstellung die Minorisierungen zu wiederholen, die sie eigentlich kritisieren wollen? Dies ist die zentrale Frage, die sich durch die vorliegende Arbeit von Johanna Schaffer zieht. Sie bearbeitet den Modus der Sichtbarkeit im Feld der visuellen Kultur unter epistemologischen, politischen und insbesondere ästhetischen Gesichtspunkten. Ihre Einwände gegen naive Vorstellungen, die Sichtbarkeit kausal mit einem Zugewinn an Macht verbinden, entwickelt Schaffer aus einem Zusammenspiel von Bildanalysen mit Theorie- und Begriffsarbeit. Insgesamt ein lesenswertes Buch, das nicht nur theoretisch fundiert ist und interessante Bildlektüren liefert, sondern auch ein (bild-analytisches Instrumentarium an die Hand gibt.How can minority groups be made visible without, however, reproducing the manner in which their minority status is formed, which is what their visual representation, in turn, intends to critique? This is the central question that runs through Johanna Schaffer’s study. She treats modes of visibility in the field of visual culture with respect to epistemology, politics, and especially aesthetics. Schaffer develops objections to naïve conceptions that causally connect visuality with an increase of power by basing her objections on the interplay between image analysis and work with theory and terminology. Overall this is a book worth reading, for it is not only theoretically founded and offers interesting readings of images, but it also equips readers with a set of instruments for (image analysis.

  15. Dick Jewell’s Found Photos

    Directory of Open Access Journals (Sweden)

    Ian Walker

    2010-12-01

    Full Text Available

    Abstract (E:

    In 1977, the young British artist Dick Jewell self-published a small book Found Photos, a collection of photobooth images that had been thrown away or torn up by the people in the photos. This essay places that book in the context of the development of interest in vernacular photography during the 1970s, and relates it to other projects using pictures made in photobooths, both before and since.

     

    Abstract (F:

    Blending Words Found In Social Media

    Directory of Open Access Journals (Sweden)

    Giyatmi Giyatmi

    2017-12-01

    Full Text Available There are many new words from the social media such as Netizen, Trentop, and Delcon. Those words include in blending. Blending is one of word formations combining two clipped words to form a brand new word. The researchers are interested in analyzing blend words used in the social media such as Instagram, Twitter, Facebook, and Blackberry Messenger. This research aims at (1 finding blend words used in the social media (2 describing kinds of blend words used in social media (3 describing the process of blend word formation used in the social media. This research uses some theories dealing with definition of blending and kinds of blending. This research belongs to descriptive qualitative research. Data of the research are English blend words used in social media. Data sources of this research are websites consisting of some English words used in social media and some social media users as the informant. Techniques of data collecting in this research are observation and simak catat. Observation is by observing some websites consisting of some English words used in social media. Simak catat is done by taking some notes on the data and encoding in symbols such as No/Blend words/Kinds of Blending. The researchers use source triangulation to check the data from the researchers with the informant and theory triangulation to determine kinds of blending and blend word formation in social media. There are115 data of blend words. Those data consists of 65 data of Instagram, 47 data of Twitter, 1 datum of Facebook, and 2 data of Blackberry Messenger. There are 2 types of blending used in social media;108 data of blending with clipping and 7 data of blending with overlapping. There are 10 ways of blend word formation found in this research.

  16. [Towards the Files. Psychoanalysis and its publishing house strategies].

    Science.gov (United States)

    Windgätter, Christof

    2009-09-01

    The following case study deals with the Internationaler Psychoanalytischer Verlag, founded 1919 in Vienna by a group around Sigmund Freud and shut down in 1938 by the Gestapo. During that time the Verlag published the titles of the contemporary psychoanalytic movement, including the first psychoanalytic dictionary, the Almanach as a yearbook, the four authoritative journals, as well as the first complete edition of Freud's writings. A single publishing house became thus responsible for the appearance of an entire theory--a unique situation without historical comparison. My thesis here is that the Verlag initiated certain strategies of publicising (e.g. centralising the movement, enforcing the company's name, labelling its activities) that were, prior to arguments and contents, constitutive for the development of psychoanalysis as well as its implementation within the field of science. Consequently, these strategies cannot be found through interpretations of psychoanalytical texts, but in the genuine files and in view of the material products (books, journals, blurbs, advertisements etc.) that were passed down from the Verlag. As an opening step, this essay explores several of those Viennese files, showing that the Verlag not only struggled with monetary and personal problems but rather and foremost launched branding, marketing and public relation campaigns as key concepts to make sciences and its particular knowledge acceptable. As a result the Verlag changed from a commercial and distributive institution to an epistemic medium.

  17. GOODS Missing Black Hole Report: Hundreds Found!

    Science.gov (United States)

    2007-10-01

    time when the universe was in its infancy, between 2.5 and 4.5 billion years old. When the astronomers peered more closely at the galaxies with Spitzer's infrared eyes, they noticed that about 200 of the galaxies gave off an unusual amount of infrared light. X-ray data from Chandra, and a technique called "stacking," revealed the galaxies were in fact hiding plump quasars inside. The scientists now think that the quasars heat the dust in their surrounding doughnut clouds, releasing the excess infrared light. "We found most of the population of hidden quasars in the early universe," said Daddi. Previously, only the rarest and most energetic of these hidden black holes had been seen at this early epoch. For decades, large populations of active black holes have been considered missing. These highly energetic structures, also called quasars, consist of a dusty, doughnut-shaped cloud that surrounds and feeds a growing supermassive black hole. They give off a lot of X-rays that can be detected as a general glow in space, but sometimes the quasars themselves can't be seen because dust and gas blocks their X-rays from our point of view. The newfound quasars are helping answer fundamental questions about how massive galaxies evolve. For instance, astronomers have learned that most massive galaxies steadily build up their stars and black holes simultaneously until they get too big and their black holes suppress star formation. The observations also suggest that collisions between galaxies might not play as large a role in galaxy evolution as previously believed. "Theorists thought that mergers between galaxies were required to initiate this quasar activity, but we now see that quasars can be active in unharrassed galaxies," said co-author David Alexander of Durham University, United Kingdom. "It's as if we were blind-folded studying the elephant before, and we weren't sure what kind of animal we had," added co-author David Elbaz of the Commissariat a l'Energie Atomique. "Now, we

  18. [An Association Between Autonomy and National Ideology: The Founding of the Association for Psychiatry and Neurology in Mecklenburg].

    Science.gov (United States)

    Kumbier, E

    2016-10-01

    Following the end of World War II, regional associations for psychiatry and neurology were founded in the Soviet Occupation Zone. Using the association in Mecklenburg as an example and considering the way society developed in the German Democratic Republic (GDR), it will be shown whether and to what degree these were increasingly subject to state control. © Georg Thieme Verlag KG Stuttgart · New York.

  19. Individual foundings and organizational foundings : their effect on employment growth in The Netherlands

    NARCIS (Netherlands)

    Koster, S.

    This study addresses the question of whether different types of new firm formation have different impacts on regional employment generation. It is shown that new establishments of existing firms, i.e., organizational foundings, have a mainly short-term positive effect. In contrast, genuinely new

  1. Hans Erich Troje: Gegenpositionen. Aspekte zur Zukunft von Ehe und Familie. Köln u.a.: Böhlau Verlag 2009.

    Directory of Open Access Journals (Sweden)

    Margret Karsch

    2010-03-01

    Full Text Available The collected volume appeared in Böhlau Verlag’s series “Legal History and Gender Research.” It contains essays by the retired legal scholar from the years 1975 to 1999 that in ideological and polemic form formulate positions on family and equity politics akin to those that have long been overhauled by gender research.Der Sammelband ist in der Reihe „Rechtsgeschichte und Geschlechterforschung“ des Böhlau Verlags erschienen. Er enthält Aufsätze des emeritierten Rechtswissenschaftlers aus den Jahren 1975 bis 1999, die in ideologischer und polemischer Form Positionen zu Familien- und Gleichstellungspolitik formulieren, wie sie in der Geschlechterforschung längst überholt sind.

  2. Rec.: "Sprachliche Säkularisierung. Semantik und Pragmatik", Hrsg. von Alicja Nagórko, Georg Olms Verlag, Hildesheim–Zürich–New York 2014, 466 S.

    Directory of Open Access Journals (Sweden)

    Anna Zielińska

    2016-12-01

    Full Text Available Review: Sprachliche Säkularisierung. Semantik und Pragmatik, ed. Alicja Nagórko, Georg Olms Verlag, Hildesheim–Zürich–New York 2014, 466 pp. The reviewed collective volume falls within the stream of research on the language of religion, yet – unlike theolinguistics, which deals with different varieties of religious texts – the presented studies focus on the use of religious vocabulary in secular contexts. The studies deal with the processes of linguistic secularisation, sociology of religion, and above all – linguistics. The volume consists of twenty-six studies by scholars for Germany, Poland and Slovakia.   Rec.: Sprachliche Säkularisierung. Semantik und Pragmatik, Hrsg. von Alicja Nagórko, Georg Olms Verlag, Hildesheim–Zürich–New York 2014, 466 S. Recenzowana monografia zbiorowa włącza się w nurt badań nad językiem religii, jednak w odróżnieniu od teolingwistyki, która zajmuje się różnymi wariantami tekstów religijnych, prezentowane badania koncentrują się na funkcjonowaniu religijnej leksyki w świeckich dyskursach. Tematyka tomu dotyczy procesów językowej sekularyzacji, badanych z perspektywy różnych dyscyplin humanistycznych: kulturoznawstwa, socjologii religii i przede wszystkim językoznawstwa. Tom składa się z 26 opracowań naukowych uczonych z Niemiec, Polski i Słowacji.

  3. Constance Gunderson, Human Trafficking: The Trafficking of Women in Northern Germany for the Purpose of Sexual Exploitation. Systematic Overview of Community Based Responses and Challenges (Bremen: Lit Verlag, 2012

    Directory of Open Access Journals (Sweden)

    Markus Meckl

    2013-03-01

    Full Text Available A review of the following book: Constance Gunderson, Human Trafficking: The Trafficking of Women in Northern Germany for the Purpose of Sexual Exploitation. Systematic Overview of Community based responses and challenges (Bremen: Lit Verlag, Bremen 2012

  4. Klinisch geval of worried well? Een beschrijving van patiënten voorafgaand aan psychoanalytische behandeling

    NARCIS (Netherlands)

    Berghout, C.C.; Zevalkink, D.J.

    2007-01-01

    The present study investigated which mental health aspects were clinically affected in 170 patients who were assigned to long-term ambulatory psychoanalytic treatment, in other words to what extent these patients were sick or distressed. At intake, patients filled in four self-report questionnaires

  5. 36 CFR 327.16 - Lost and found articles.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false Lost and found articles. 327... CHIEF OF ENGINEERS § 327.16 Lost and found articles. All articles found shall be deposited by the finder at the Manager's office or with a ranger. All such articles shall be disposed of in accordance with...

  6. 50 CFR 25.22 - Lost and found articles.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false Lost and found articles. 25.22 Section 25.22 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR... Lost and found articles. Lost articles or money found on a national wildlife refuge are to be...

  7. Mutations found in the Danish population causing Hereditary Hemorrhagic Telangiectasia

    DEFF Research Database (Denmark)

    Tørring, Pernille M; Brusgaard, Klaus

    2011-01-01

    been performing genetic screening of patients and relatives with HHT. The molecular genetic screening serves dual purposes, a) as part of the clinical management as genotype/phenotype correlations exists, b) to identify asymptomatic family members. Materials and Methods Inclusion of patient’s who were....... Results In 61 families we found mutations in either ENG (N=35) or ACVLR1 (N=26). In ENG a total of 22 different mutations were found 16 was unreported. In ACVLR1 24 different mutations were found 13 was unreported. The mutations were mainly of a familial character all though in ENG a single mutation...... is present in 11 families and 2 mutations are represented in 2 families. Likewise in ACVLR1 2 mutations was found in 2 different families. I ENG 1 and in ACVLR1 3 families had major deletions found by MLPA. No mutations were found in MADH4. Conclusion The majority of mutations found during clinical genetic...

  8. 75 FR 71744 - Founding Fathers Advisory Committee (FFAC)

    Science.gov (United States)

    2010-11-24

    ... the Founding Fathers Advisory Committee. The Committee will advise the Archivist of the United States...: National Archives and Records Administration, 700 Pennsylvania Avenue, NW., Archivist's Board Room, Room...

  9. Protective mechanism against cancer found in progeria patient cells

    Science.gov (United States)

    NCI scientists have studied cells of patients with an extremely rare genetic disease that is characterized by drastic premature aging and discovered a new protective cellular mechanism against cancer. They found that cells from patients with Hutchinson Gi

  10. Minimal founded semantics for disjunctive logic programs and deductive databases

    OpenAIRE

    Furfaro, Filippo; Greco, Gianluigi; Greco, Sergio

    2003-01-01

    In this paper, we propose a variant of stable model semantics for disjunctive logic programming and deductive databases. The semantics, called minimal founded, generalizes stable model semantics for normal (i.e. non disjunctive) programs but differs from disjunctive stable model semantics (the extension of stable model semantics for disjunctive programs). Compared with disjunctive stable model semantics, minimal founded semantics seems to be more intuitive, it gives meaning to programs which ...

  11. A novel Au SINE sequence found in a gymnosperm.

    Science.gov (United States)

    Yagi, Eiki; Akita, Toru; Kawahara, Taihachi

    2011-01-01

    Although many SINE families have been identified in the animal kingdom, only a few SINE families have been identified in plants, and their distribution is somewhat limited. The Au SINE (Au) has been found discontinuously in basal angiosperms, monocots, and eudicots. In this study, we examined the presence of the Au in gymnosperms and ferns by PCR using internal primers for Au. As a result, we found Au in a gymnosperm species, Ephedra ciliata. Therefore, Au was supposed to be present in the common ancestor of angiosperms and gymnosperms. The Au in E. ciliate was 15 bp shorter than the consensus sequence, which is similar to the Au SINE found in Glycine. However, the 3'end of the Au found in E. ciliate was more similar to the 3'end of the Medicago-type Au than that of the Glycine-type Au. A phylogenetic tree indicated that the Au sequence from E. ciliate is more closely related to the sequence found in Glycine than that found in Medicago/Lotus. These results indicated that Au were present in both angiosperms and gymnosperms.

  12. [Four alien medical mollusk found in Dapeng Peninsula, Shenzhen City].

    Science.gov (United States)

    Cao, Shi-Kui; Zhuang, Xin; Hu, Guan-Guan

    2014-12-01

    To investigate the alien snails in Dapeng Peninsula, Shenzhen City. The survey on the snail diversity in Dapeng Peninsula was carried out from August 2012 to Jan 2013, and the species of the alien snails were identified according to the shell morphology. Four species of alien snails including Achatinafulica, Pomacea canaliculata, Physa acuta, and Biomphalaria straminea were found in Dapeng Peninsula, P. acuta was found in all of the collected sites, A. fulica and P. canaliculata were distributed in five regions except Yangmeikeng area, and B. straminea was just found in Dapeng Town. Four species of important alien snails invade widely in Dapeng Peninsula, Shenzhen City. As their potential risk to the disease transmission and agriculture production, the relative departments should strengthen the control and prevention.

  13. Reindeer warble fly larvae found in red deer

    Directory of Open Access Journals (Sweden)

    A. C. Nilssen

    1988-06-01

    Full Text Available Seven third instar larvae of the reindeer warble fly (Hypoderma (=Oedemagena tarandi were found in a 2-3 year old male red deer {Cervus elaphus shot on 14 November 1985 at Todalen, western Norway. This it, the first report of H. tarandi from red deer. In reindeer third instar larvae are found from February to June, and the unusual date of this record indicates a delayed development of the larvae due to abnormal host reactions. Warble fly larvae, probably H. tarandi, are also reported from moose {Alces alces in northern Norway.

  14. Reindeer warble fly larvae found in red deer

    OpenAIRE

    Nilssen, A C; Gjershaug, J.O.

    1988-01-01

    Seven third instar larvae of the reindeer warble fly (Hypoderma (=Oedemagena) tarandi) were found in a 2-3 year old male red deer {Cervus elaphus) shot on 14 November 1985 at Todalen, western Norway. This it, the first report of H. tarandi from red deer. In reindeer third instar larvae are found from February to June, and the unusual date of this record indicates a delayed development of the larvae due to abnormal host reactions. Warble fly larvae, probably H. tarandi, are also reported from ...

  15. Parasitic amoebae found in water bodies of Ukraine.

    Science.gov (United States)

    Patsyuk, Marina

    2017-12-01

    Two parasitic amoebian species are found in mollusks of the water bodies of Ukraine. Vahlkampfia sp. is found in hepatopankreas of Unio conus Spengler, 1793, and Acanthamoeba sp. is observed in mantle cavity of Viviparus viviparus Linnaeus, 1758. For these protist species, the mollusks are shown to be intermediate hosts where amoebae feed and reproduce. An experimental infection with Vahlkampfia sp. and Acanthamoeba sp. was not successful, no pathological changes in mollusks were observed. These amoebae are successfully cultured in fresh water and agar medium, hence we can safely consider them free-living. Copyright © 2017 Elsevier Inc. All rights reserved.

  16. On the approximation of crack shapes found during inservice inspection

    Energy Technology Data Exchange (ETDEWEB)

    Bhate, S.R.; Chawla, D.S.; Kushwaha, H.S. [Bhabha Atomic Research Centre, Bombay (India)] [and others

    1997-04-01

    This paper addresses the characterization of axial internal flaw found during inservice inspection of a pipe. J-integral distribution for various flaw shapes is obtained using line spring finite, element method. The peak J-value and its distribution across the crack is found to be characteristic feature of each shape. The triangular shape yields peak J-value away from the center, the point of depth. The elliptic approximation results in large overestimate of J-value for unsymmetric flaws. Triangular approximation is recommended for such flaws so that further service can be obtained from the component.

  17. The trapped heavy noble gases in recently found Martian meteorites

    OpenAIRE

    Busemann, H.; Eugster, O.

    2002-01-01

    The composition of the trapped Ar, Kr, and Xe in the Martian meteorites Los Angeles, Say Al Uhaymir 005/008, and 094 is discussed and found to be consistent with a mixture of Martian mantle and atmosphere noble gases and terrestrial contamination.

  18. Incidence and Distribution of Pulp Stones Found in Radiographic ...

    African Journals Online (AJOL)

    Pulp stones (PS) are discrete calcified masses found in the dental pulp, in the pulp tissue or become attached to or embedded into the dentine.[1] Structurally, pulp stones can be classified as true or false, the former being made of dentine and lined by odontoblasts, whereas false pulp stones are formed from degenerating ...

  19. Zoonotic Enterocytozoon bieneusi Genotypes found in Brazilian sheep

    Science.gov (United States)

    The presence of Enterocytozoon bieneusi in sheep has been reported in only three countries worldwide. The present study has found E. bieneusi in Brazilian sheep for the first time; in 24/125 (19.2%) fecal samples by PCR and in 8/10 (80%) farms from three diverse locations. A significantly greater...

  20. Incidence and Distribution of Pulp Stones Found in Radiographic ...

    African Journals Online (AJOL)

    Dr. Enes Tan,. Department of Orthodontics, Faculty of Dentistry, Kırıkkale University,. Kırıkkale, Turkey. E-mail: dentistan@yahoo.com. Introduction. Pulp stones (PS) are discrete calcified masses found in the dental pulp, in the pulp tissue or become attached to or embedded into the dentine.[1] Structurally, pulp stones can be.

  1. Nutritive value of Lepidoptara litoralia (edible caterpillar) found in ...

    African Journals Online (AJOL)

    Nutritive value of Lepidoptara litoralia (edible caterpillar) found in Jos Nigeria: implication for food security and poverty alleviation. ... The live caterpillars were hand-picked from bushes in the month of September, and processed under laboratory conditions according to local methods used by the indigenes. The processed ...

  2. Survey of possible pathogenic organisms found in urine and vaginal ...

    African Journals Online (AJOL)

    The organisms encountered were Yeast cells, Pus cells and Trichomonas vaginalis. 5(2.5%) positive samples with Trichomonas vaginalis were detected among the examined patients while none of the students were found infected with Trichomonas vaginalis. Yeast cells were the most frequently encountered organism ...

  3. THE IDENTIFICATION OF POTAMOGETONACEAE FRUITS FOUND IN THE NETHERLANDS

    NARCIS (Netherlands)

    CAPPERS, RTJ

    1993-01-01

    From recent litter, deposited by both the River Rhine and the North Sea, and from a Weichselian Pleniglacial deposit, many pondweed endocarps were isolated and identified. Seventeen species could be identified, among which were two subfossil species that were also regularly found in recently

  4. Levels of cadmium in cigarette brands found in Zamfara state ...

    African Journals Online (AJOL)

    The levels of cadmium were determined in some cigarette brands found in Zamfara state, North-west Nigeria. The solutions of the samples were prepared using the dry-ash method. The levels of cadmium in the solution were determined using atomic absorption spectrometer. The absorbance readings of the elements were ...

  5. Mniaecia jungermanniae and Puttea margaritella (lichenized Ascomycota found in Poland

    Directory of Open Access Journals (Sweden)

    Paweł Czarnota

    2013-06-01

    Full Text Available Two hepaticolous fungi, Mniaecia jungermanniae and Puttea margaritella rarely recorded in Europe have recently been found in Polish Western Carpathians. Both species are also reported here for the first time from Poland. Notes on their taxonomy, ecology and distribution are provided.

  6. On an aberrant Form of Truncatellina found in the Netherlands

    NARCIS (Netherlands)

    Bayer, Ch.

    1938-01-01

    From Mr. Ph. van Hooven I received a Truncatellina, found by himself on October 22nd, 1934, near Katwijk aan Zee (South Holland), at the foot of the downs. Judging by the soft parts, still present in the shell, this little snail must either have been collected in the living state or shortly after

  7. The interpretation of traces found on adhesive tapes

    NARCIS (Netherlands)

    Wieten, R.; de Zoete, J.; Blankers, B.; Kokshoorn, B.

    2015-01-01

    In violent crimes, adhesive tapes such as duct tape are often used by perpetrators e.g. to tie up a victim. In the forensic examination of such tapes many different types of traces can be found, such as finger marks and human biological traces. These traces are first interpreted at source level.

  8. International Team Shows that Primes Can Be Found in Surprising ...

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 3; Issue 3. International Team Shows that Primes Can Be Found in Surprising Places. Andrew Granville. Research News Volume 3 Issue 3 March 1998 pp 71-72. Fulltext. Click here to view fulltext PDF. Permanent link:

  9. The chemical oxidation of lignin found in Sappi Saiccor dissolving ...

    African Journals Online (AJOL)

    Sappi Saiccor (situated in Durban, South Africa) dissolving pulp mill effluent, produced from an acid bisulphite pulping process, uses acacia and eucalyptus hardwoods to produce a unique and different blend of lignin that has not been previously studied. The chemical oxidation of lignin found in Sappi Saiccor's effluent has ...

  10. The burden, antibiogram and pathogenicity of bacteria found in ...

    African Journals Online (AJOL)

    Municipal wastes may harbour microbial pathogens but the quantum and diseasecausing capacities of such organisms are rarely investigated. This study sought to establish the burden, antibiogram and pathogenicity of bacteria in 4 selected waste dumpsites and those found on hands and clothings of the respective waste ...

  11. An Analysis of Linguistic Resources Found in the Advertising ...

    African Journals Online (AJOL)

    This study analyses linguistic resources found in the advertising discourse used by three banking institutions in Zimbabwe. The institutions are the Commercial Bank of Zimbabwe (CBZ), Trust Bank of Zimbabwe (Trust Bank) and the Agricultural Bank of Zimbabwe (Agribank). The researcher takes a keen interest in banking ...

  12. Red-Flanked Duiker Cephalophus rufilatus found in Bugungu Game ...

    African Journals Online (AJOL)

    Red-Flanked Duiker Cephalophus rufilatus found in Bugungu Game Reserve, Uganda. C Allan. Abstract. Journal of East African Natural History Vol. 85 (1&2) 1996: 87-90. Full Text: EMAIL FULL TEXT EMAIL FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT.

  13. Interrogating the Founding Gestures of the New Materialism

    Directory of Open Access Journals (Sweden)

    Dennis Bruining

    2016-11-01

    Full Text Available In this article, I aim to further thinking in the broadly ‘new materialist’ field by insisting it attends to some ubiquitous assumptions. More specifically, I critically interrogate what Sara Ahmed has termed ‘the founding gestures of the “new materialism”’. These founding rhetorical gestures revolve around a perceived neglect of the matter of materiality in ‘postmodernism’ and ‘poststructuralism’ and are meant to pave the way for new materialism’s own conception of matter-in/of-the-world. I argue in this article that an engagement with the postmodern critique of language as constitutive, as well as the poststructuralist critique of pure self-presence, does not warrant these founding gestures to be so uncritically rehearsed. Moreover, I demonstrate that texts which rely on these gestures, or at least the ones I discuss in this article, are not only founded on a misrepresentation of postmodern and poststructuralist thought, but are also guilty of repeating the perceived mistakes of which they are critical, such as upholding the language/matter dichotomy. I discuss a small selection of texts that make use of those popular rhetorical gestures to juxtapose the past that is invoked with a more nuanced reading of that past. My contention is that if ‘the founding gestures of the “new materialism”’ are not addressed, the complexity of the postmodern and poststructuralist positions continues to be obscured, with damaging consequences for the further development of the emerging field of new materialism, as well as our understanding of cultural theory’s past.

  14. Donald Menzel: His Founding and Funding of Solar Observatories.

    Science.gov (United States)

    Welther, B. L.

    2002-12-01

    In January 1961 Donald Menzel wrote to his cousin, M. H. Bruckman, "I am proudest of the observatories that I have built in the West." The first of those facilities, a solar observatory, was founded in 1940 in Colorado and later came to be known as the High Altitude Observatory. The second one, also a solar observatory, was founded a dozen years later at Sacramento Peak in New Mexico. The third facility, however, established at Fort Davis, Texas, was the Harvard Radio Astronomy Observatory. Although Menzel was primarily a theoretical astrophysicist, renowned for his studies of the solar chromosphere, he was also an entrepreneur who had a talent for developing observatories and coping with numerous setbacks in funding and staffing. Where many others would have failed, Menzel succeeded in mentoring colleagues and finding sources of financial support. This paper will draw primarily on letters and other materials in the Harvard University Archives.

  15. Positive and Negative Themes Found in Superhero Films.

    Science.gov (United States)

    Bauer, Matthew; Georgeson, Andrew; McNamara, Caitlin; Wakefield, Bryan H; King, Tonya S; Olympia, Robert P

    2017-12-01

    Superhero films have become incredibly popular. The objective of this study was to determine the positive and negative themes found in a select number of superhero films. A total of 30 superhero films were analyzed. The average numbers of positive and negative themes were 19.4 and 29.5 mean events per hour for all included films, respectively. The most common positive themes were "assisting others/protecting the public," "positive relationships with family/friends," and "teamwork/collaboration." The most common negative themes were "acts of violence/fighting," "use of guns/knives/lethal weapons," and "bullying/intimidation/torture." Based on the superhero films included in our study, the number of negative themes, especially acts of violence, outweighs positive themes. Although an exposure to positive themes found in superhero films may be beneficial to the development of children, pediatric health care providers should counsel children and their families in an attempt to limit their exposure to violence.

  16. Onset of fights and mutual assessment in ant founding queens.

    Science.gov (United States)

    Berthelot, Kévin; Portugal, Felipe Ramon; Jeanson, Raphaël

    2017-03-01

    In animals, the progress and outcome of contests can be influenced by an individual's own condition, their opponent's condition or a combination of the two. The use of chemical information to assess the quality of rivals has been underestimated despite its central role in the regulation of social interactions in many taxa. Here, we studied pairwise contests between founding queens of the ant Lasius niger to investigate whether the decision to engage in agonistic interactions relies on self-assessment or mutual assessment. Queens modulated their aggressive behaviours depending on both their own status and their opponent's status. We found no influence of lipid stores or size on the onset of fights. However, differences in cuticular chemical signatures linked to fertility status accurately predicted the probability of behaving aggressively in pairs. Our study thus suggests that ant queens could rely on mutual assessment via chemical cues to make informed decisions about fight initiation. © 2017. Published by The Company of Biologists Ltd.

  17. The Subversion of Factual Discourse in Found Footage Films

    Directory of Open Access Journals (Sweden)

    Claudio Vescia Zanini

    2016-04-01

    Full Text Available Este artigo analisa como o design textual de filmes do formato found footage subverte o discurso factual a fim de potencializar a pretendida sensação de horror na tela. Filmes como Canibal Holocausto (1980, A Bruxa de Blair (1999, Atividade Paranormal (2007 e A Forca (2015 exploram a confusão entre realidade e ficção, interferindo na maneira como parte da audiência reage aos filmes. O artigo também parte do princípio que o found footage é um produto natural da pós-modernidade, que tem a cultura da convergência (JENKINS, 2008 e o desaparecimento do real como duas de suas maiores características.

  18. Founded Semantics and Constraint Semantics of Logic Rules

    OpenAIRE

    Liu, Yanhong A.; Stoller, Scott D.

    2016-01-01

    This paper describes a simple new semantics for logic rules, founded semantics, and its straightforward extension to another simple new semantics, constraint semantics. The new semantics support unrestricted negation, as well as unrestricted existential and universal quantifications. They are uniquely expressive and intuitive by allowing assumptions about the predicates and rules to be specified explicitly. They are completely declarative and easy to understand and relate cleanly to prior sem...

  19. Two Cases of Ancylostomiasis Found in Saga City.

    OpenAIRE

    原田, 良策; 木下, 耶夫; 高橋, 正純 [訂正; 宇佐, 利隆; 曽我, 節子; 月舘, 説子; 藤田, 紘一郎

    1986-01-01

    We have reported two cases of Ancylostoma duodenale which were found in Saga City. Case 1: A 82-year-old woman who had anemia, edema and back pain was admitted to Saga National Hospital because of palpitation. The radiological and endoscopic studies revealed no existence of abnormality. But the eggs of hookworm were detected in the stool, and subsequently the larvae of Ancylostoma duodenale were also detected by the faecal culture. She received the therapy with pyrantel pamoate and the eggs i...

  20. Novel pyrazine metabolites found in polymyxin biosynthesis by Paenibacillus polymyxa

    DEFF Research Database (Denmark)

    Beck, Hans Christian; Hansen, Anne M; Lauritsen, Frants R

    2003-01-01

    A complex mixture of methyl-branched alkyl-substituted pyrazines was found in the growth medium of the polymyxin-producing bacterium Paenibacillus polymyxa, and of these, seven are new natural compounds. A total of 19 pyrazine metabolites were identified. The dominant metabolite was 2...... supplementation. The other pyrazine metabolites, all related pyrazines with either one, two or three alkyl substituents, were identified by means of their mass spectral data and/or co-elution with authentic standards....

  1. Antitumor Activity of Monoterpenes Found in Essential Oils

    Directory of Open Access Journals (Sweden)

    Marianna Vieira Sobral

    2014-01-01

    Full Text Available Cancer is a complex genetic disease that is a major public health problem worldwide, accounting for about 7 million deaths each year. Many anticancer drugs currently used clinically have been isolated from plant species or are based on such substances. Accumulating data has revealed anticancer activity in plant-derived monoterpenes. In this review the antitumor activity of 37 monoterpenes found in essential oils is discussed. Chemical structures, experimental models, and mechanisms of action for bioactive substances are presented.

  2. Inheriting, marrying, and founding farms: women's place on the land.

    Science.gov (United States)

    Osterud, Grey

    2011-01-01

    This article considers rural women's place on the land in south-central New York during the first half of the twentieth century. Based on a community history and ethnographic study conducted during the 1980s, the article draws on women's oral narratives to explore the connections between women's sense of agency and their relationship to the land through descent and inheritance, marriage into a landowning family, founding a farm in partnership, and the experience of dispossession.

  3. Chemical Analysis of Counterfeit Hepatitis C Drug Found in Japan.

    Science.gov (United States)

    Uchiyama, Nahoko; Kamakura, Hiroyuki; Masada, Sayaka; Tsujimoto, Takashi; Hosoe, Junko; Tokumoto, Hiroko; Maruyama, Takuro; Goda, Yukihiro; Hakamatsuka, Takashi

    2017-10-01

    In January 2017, counterfeits of the hepatitis C drug 'HARVONI® Combination Tablets' (HARVONI®) were found at a pharmacy chain through unlicensed suppliers in Japan. A total of five lots of counterfeit HARVONI® (samples 1-5) bottles were found, and the ingredients of the bottles were all in tablet form. Among them, two differently shaped tablets were present in two of the bottles (categorized as samples 2A, 2B, 4A, and 4B). We analyzed the total of seven samples by high-resolution LC-MS, GC-MS and NMR. In samples 2A, 3 and 4B, sofosbuvir, the active component of another hepatitis C drug, SOVALDI® Tablets 400 mg (SOVALDI®), was detected. In sample 4A, sofosbuvir and ledipasvir, the active components of HARVONI®, were found. A direct comparison of the four samples and genuine products showed that three samples (2A, 3, 4B) are apparently SOVALDI® and that sample 2A is HARVONI®. In samples 1 and 5, several vitamins but none of the active compounds usually found in HARVONI® (i.e., sofosbuvir and ledipasvir) were detected. Our additional investigation indicates that these two samples are likely to be a commercial vitamin supplement distributed in Japan. Sample 2B, looked entirely different from HARVONI® and contained several herbal constitutents (such as ephedrine and glycyrrhizin) that are used in Japanese Kampo formulations. A further analysis indicated that sample 2B is likely to be a Kampo extract tablet of Shoseiryuto which is distributed in Japan. Considering this case, it is important to be vigilant to prevent a recurrence of distribution of counterfeit drugs.

  4. Human remains found in two wells: a forensic entomology perspective.

    Science.gov (United States)

    Magni, Paola A; Borrini, Matteo; Dadour, Ian R

    2013-09-01

    When estimating the time since death or manner of death, the identification and the pathological evaluations of a body are generally impeded by post mortem changes. Research and case studies help experts to achieve a more accurate diagnosis, but at present there is scant literature covering topics concerning forensic science and decompositional processes in aquatic environments. The two case studies presented each involve a decomposed body found in a unique aquatic environment; namely wells containing ground water. In Case 1 an entomologist attended the scene and in Case 2 an entomologist was only involved after 20 months when it was decided that the insect evidence collected at the second autopsy may be useful in determining a time frame. The first case highlights the problems associated with body retrieval from aquatic environments as the body was removed it dismembered. Fortunately, the well was able to be drained, so much of the insect evidence was retrieved. In the second case the body was found dismembered but the entomological evidence was overlooked and lost. During the second autopsy insects were found, collected, and sent to an entomologist to help clarify the post mortem interval.

  5. Extragalactic Planetary Nebulae Candidates Found with HST/LEGUS

    Science.gov (United States)

    Kowalski, Laura; Churnetski, Kristen; Pellerin, Anne; Annibali, Francesca; LEGUS

    2018-01-01

    We present the results of an extensive search for planetary nebulae in nearby galaxies observed for the Legacy ExtraGalactic Ultraviolet Survey. A total of 32 galaxies were examined and 166 planetary nebula candidates were found. Images from the Hubble Space Telescope in ~BVI filters were visually inspected to identify potential candidates based on their color. The presence of strong emission lines from [OIII]4959, 5007A in planetary nebulae enhances their brightness in the F555W or F606W filter compared to other, more ordinary stars. Making use of the LEGUS stellar photometric catalogs, color-magnitude and color-color diagrams were used to eliminate outliers.

  6. A study of the family Dentaliidae (molusca) found in China

    Science.gov (United States)

    Qi, Zhongyan; Ma, Xiutong

    1989-06-01

    This paper describes 14 species of the family Dentaliidae collected from China by the Institute of Oceanology, Academia Sinica during the surveys on marine invertebrate animals and benthos in the past years. Of which 4 species are considered as new to science; 2 species are first recorded in China. The system adopted is mainly that of T. Habe (1964), but reference is also made to the works of W. Emerson (1962), P. Palmer (1974) and S. D. Chistikov. About 20 Chinese species of Dentaliidae have been described. We consider our study is still not complete and are sure that more species shall be found in further studies.

  7. Description of Idiomatic Expression Found in Guns N’ Roses songs

    OpenAIRE

    Hutabarat, Chandra Xaverius Putra

    2011-01-01

    A paper with title “ Description of Idiomatic Expression Found in Guns N’ Roses Songs. Describing idiomatic expression in three songs of Guns N’ Roses, which are chosen randomly in Use Your Illusion I album. The method of reseach applies in this study is library reseach, and method of analysis the data is descriptive method. This study is analyzed because most of people can sing a English song, but most of them can not understand the meaning of the song. Describing idiomatic expression in a ...

  8. Engineered biomimicry: polymeric replication of surface features found on insects

    Science.gov (United States)

    Pulsifer, Drew P.; Lakhtakia, Akhlesh; Martín-Palma, Raúl J.; Pantano, Carlo G.

    2011-04-01

    By combining the modified conformal-evaporated-film-by-rotation (M-CEFR) technique with nickel electroforming, we have produced master negatives of nonplanar biotemplates. An approximately 250-nm-thick conformal coating of nanocrystaline nickel is deposited on a surface structure of interest found in class Insecta, and the coating is then reinforced with a roughly 60-μm-thick structural layer of nickel by electroforming. This structural layer endows the M-CEFR coating with the mechanical robustness necessary for casting or stamping multiple polymer replicas of the biotemplate. We have made master negatives of blowfly corneas, beetle elytrons, and butterfly wings.

  9. Human axial chromatic aberration found not to decline with age.

    Science.gov (United States)

    Ware, C

    1982-01-01

    Millodot (1976) reported a dramatic decline in the amount of axial chromatic aberration of the human eye with age. The present study represents a failure to replicate that finding using a more standard procedure. No difference in chromatic aberration was found between a young and an older group of observers. Also, the chromatic aberrations of two observers which had been measured 25 years previously showed no decline when these measurements were repeated, even though their ages at first and second testing straddled the period over which Millodot reported the most change in chromatic aberration.

  10. Bell founding – the past and the present

    Directory of Open Access Journals (Sweden)

    M. Cebulak

    2010-07-01

    Full Text Available This paper outlines the history of bell founding. The exceptional character of bells, which are products of supracultural importance, was stressed. The complexity of the bell manufacturing process and a unique approach to the technology design were highlighted. Basing onthe data obtained from foundry shops currently operating in Poland, known as bell-casting foundries, the main guidelines for the bellcasting process as used nowadays by the Felczyński Foundry with long-standing traditions and Wojdak’s Foundry, both of which arecasting bells according to modern technologies, using modern moulding materials and metal alloys, were described.

  11. Mildew fungi found in termites (Reticulitermes lucifugus and their nests

    Directory of Open Access Journals (Sweden)

    A. Wójcik

    2015-04-01

    Full Text Available This paper presents the results of observation of mould growth in laboratory colonies of termites. It also attempts to determine the species of mould fungi present in the research laboratory and the main colonies and their entomopathogenic for the termites. The following four species were found in test termite colonies: Trichoderme viride, Mucor himeralis, Rhizopus nigricans, Aspergillus sp., Aspergillus flavus, Alternaria sp., Penicylium verucosum and Fusarium sp. were recognisable in test colonies with domestic and exotic wood. Morphological observations of the fungi were carried out using a microscope with a 40x magnification. The growth of mould fungi in test containers caused death of whole termite colonies.

  12. CF Metadata Conventions: Founding Principles, Governance, and Future Directions

    Science.gov (United States)

    Taylor, K. E.

    2016-12-01

    The CF Metadata Conventions define attributes that promote sharing of climate and forecasting data and facilitate automated processing by computers. The development, maintenance, and evolution of the conventions have mainly been provided by voluntary community contributions. Nevertheless, an organizational framework has been established, which relies on established rules and web-based discussion to ensure smooth (but relatively efficient) evolution of the standard to accommodate new types of data. The CF standard has been essential to the success of high-profile internationally-coordinated modeling activities (e.g, the Coupled Model Intercomparison Project). A summary of CF's founding principles and the prospects for its future evolution will be discussed.

  13. [Two cases reports of pancreatic endocrine microadenoma incidentally found].

    Science.gov (United States)

    Coulibaly, Béma; Delage-Corre, Manuela; Durand-Fontanier, Sylvaine; Mathonnet, Muriel; Paraf, François; Labrousse, François

    2013-12-01

    A 59-year-old male, was admitted to our hospital for a tumor of the pancreatic tail. Serum CEA and CA 19-9 levels were normal. Splenopancreasectomy found a desmoid tumour. A 69-year-old male was referred to our institution for chronic anemia and inflammatory syndrome with splenomegaly. Splenectomy showed an important splenic congestion and siderosis. Both patients had a type 2 diabetes mellitus. Furthermore, histological examination revealed pancreatic endocrine microadenomas. The two patients' postoperative course was unremarkable. Eleven and 24 months respectively after the diagnosis, the patients are alive and well, with no tumor recurrence. Copyright © 2013 Elsevier Masson SAS. All rights reserved.

  14. Allan Hills 77005 - A new meteorite type found in Antarctica

    Science.gov (United States)

    Mcsween, H. Y., Jr.; Taylor, L. A.; Stolper, E. M.

    1979-01-01

    A unique 482.5 g meteorite found in Antarctica appears to be related by igneous differentiation to shergottite achondrites, which have close similarities with terrestrial basaltic rocks. Zoned maskelynite with similar compositional ranges and plagioclase of such intermediate compositions as are unknown in other achondrites occur in both shergottites and the Allan Hills meteorite. The degree of silica saturation, however, strongly distinguishes the two meteorite types. It is suggested that the Allan Hills meteorite may represent a cumulate rock formed earlier than the shergottites from the same or a similar parent magma.

  15. Serological markers of Bornavirus infection found in horses in Iceland.

    Science.gov (United States)

    Björnsdóttir, Sigríður; Agustsdóttir, Elfa; Blomström, Anne-Lie; Oström, Inga-Lena Örde; Berndtsson, Louise Treiberg; Svansson, Vilhjálmur; Wensman, Jonas Johansson

    2013-11-01

    In a stable of eight horses in Northern Iceland, six horses presented with clinical signs, such as ataxia and reduced appetite, leading to euthanasia of one severely affected horse. Serological investigations revealed no evidence of active equine herpes virus type 1 infection, a common source of central nervous system disease in horses, nor equine arteritis virus and West Nile virus. Another neurotropic virus, Borna disease virus, was therefore included in the differential diagnosis list. Serological investigations revealed antibodies against Borna disease virus in four of five horses with neurological signs in the affected stable. One horse without clinical signs was seronegative. Four clinically healthy horses in the stable that arrived and were sampled one year after the outbreak were found seronegative, whereas one of four investigated healthy horses in an unaffected stable was seropositive. This report contains the first evidence of antibodies to Borna disease virus in Iceland. Whether Borna disease virus was the cause of the neurological signs could however not be confirmed by pathology or molecular detection of the virus. As Iceland has very restricted legislation regarding animal imports, the questions of how this virus has entered the country and to what extent markers of Bornavirus infection can be found in humans and animals in Iceland remain to be answered.

  16. Functional significance of rare neuroligin 1 variants found in autism.

    Directory of Open Access Journals (Sweden)

    Moe Nakanishi

    2017-08-01

    Full Text Available Genetic mutations contribute to the etiology of autism spectrum disorder (ASD, a common, heterogeneous neurodevelopmental disorder characterized by impairments in social interaction, communication, and repetitive and restricted patterns of behavior. Since neuroligin3 (NLGN3, a cell adhesion molecule at the neuronal synapse, was first identified as a risk gene for ASD, several additional variants in NLGN3 and NLGN4 were found in ASD patients. Moreover, synaptopathies are now known to cause several neuropsychiatric disorders including ASD. In humans, NLGNs consist of five family members, and neuroligin1 (NLGN1 is a major component forming a complex on excitatory glutamatergic synapses. However, the significance of NLGN1 in neuropsychiatric disorders remains unknown. Here, we systematically examine five missense variants of NLGN1 that were detected in ASD patients, and show molecular and cellular alterations caused by these variants. We show that a novel NLGN1 Pro89Leu (P89L missense variant found in two ASD siblings leads to changes in cellular localization, protein degradation, and to the impairment of spine formation. Furthermore, we generated the knock-in P89L mice, and we show that the P89L heterozygote mice display abnormal social behavior, a core feature of ASD. These results, for the first time, implicate rare variants in NLGN1 as functionally significant and support that the NLGN synaptic pathway is of importance in the etiology of neuropsychiatric disorders.

  17. Checklist of helminths found in Patagonian wild mammals.

    Science.gov (United States)

    Fugassa, Martin H

    2015-09-03

    Using available reports, a checklist of the recorded helminth parasites of wild mammals from Patagonia was generated. Records of parasites found in Patagonia were included, together with records from mammals in áreas outside of Patagonia but whose range extends into Patagonia. Information about the host, localities, and references were also included. A total of 1323 records (224 Cestoda, 167 Trematoda, 894 Nematoda, 34 Acanthocephala, and 4 Pentastomida) belonging to 452 helminth species (77 Cestoda, 76 Trematoda, 277 Nematoda, 21 Acanthocephala, and 1 Pentastomida) found in 57 native mammals (22 Rodentia, 4 Didelphimorphia 1 Microbiotheria, 7 Chiroptera, 5 Cingulata, and 13 Carnivora) were listed. However, only 10.6 % of the reports were conducted on samples from Patagonia and corresponded to 25% of mammals in the region. In addition, many studies were made on a few species and, for example, 52% corresponded to studies made on Lama guanicoe. This suggests the need to increase efforts to know the parasitic fauna in a peculiar region as is the Patagonia. This is the first compilation of the helminth parasites of mammals in Argentine Patagonia and is important for parasitological and paleoparasitological studies.

  18. Newly Found Seal of a Byzantine Strategos of Preslav

    Directory of Open Access Journals (Sweden)

    Nikolay Kanev

    2017-11-01

    Full Text Available The article aims at giving currency in the scholarly circles to a new Byzantine lead seal found in Pliska in 2016. This lead bulla is 2,5 mm thick, it has a diameter of 22 mm and is preserved in a very good condition. The stamp is of good quality but unfortunately, it has not been well centred and because of this part of the impression and the legend have remained outside the lead core (Fig.. However, the seal is in a sufficiently good shape and its impression is clear enough to allow to ascertain with certainty that it is a new parallel copy of an already known lead seal of a Byzantine stratēgos of which eight copies have been found and published so far. Seven of these copies come from Preslav and one has been found in the vicinity of Silistra. It is situated on the obverse of this lead bulla, an image of a blossoming doubly intersected patriarchal cross on a pedestal of two steps, inserted into a double granulated circle. The invocation “Κύριε βοήθει τῷ σῷ δούλῳ”, of which the letters R . ΗΘΙΤωCω have been preserved, is written in the form of a circle round the image. On the reverse of the lead seal, clearly enough can be seen the first four lines of the five-line written inscription. The complete deciphering of the legend is as follows: “+ Κύριε βοήθει τῷ σῷ δούλῳ Ἰωάννῃ βασιλικῷ πρωτοσπαθαρίῳ καὶ στρατηγῷ Περσκλάβας”, in translation: O, Lord, help your servant John, imperial prōtospatharios and stratēgos of Persklava (i.e. Preslav. The seal is dated back to the first quarter of the 11th century.

  19. Survey of Legionella Species Found in Thai Soil

    Directory of Open Access Journals (Sweden)

    Tatiana C. Travis

    2012-01-01

    Full Text Available Members of the Gram-negative genus Legionella are typically found in freshwater environments, with the exception of L. longbeachae, which is present in composts and potting mixes. When contaminated aerosols are inhaled, legionellosis may result, typically as either the more serious pneumonia Legionnaires’ disease or the less severe flu-like illness Pontiac fever. It is presumed that all species of the genus Legionella are capable of causing disease in humans. As a followup to a prior clinical study of legionellosis in rural Thailand, indigenous soil samples were collected proximal to cases’ homes and workplaces and tested for the presence of legionellae by culture. We obtained 115 isolates from 22/39 soil samples and used sequence-based methods to identify 12 known species of Legionella represented by 87 isolates.

  20. Rotaviral RNA found in wastewaters from hospital laundry.

    Science.gov (United States)

    Fijan, Sabina; Poljsak-Prijatelj, Mateja; Steyer, Andrej; Koren, Srecko; Cencic, Avrelija; Sostar-Turk, Sonja

    2006-01-01

    The aim of this prospective study was to determine the presence of rotaviral RNA in water from a hospital laundry. Since rotaviruses are known as major causal agents of diarrhoea in humans, it is necessary that laundering hospital textiles results in efficient chemo-thermal disinfection, thus minimizing the possibility of transmission of rotaviruses to immune-compromised patients in hospitals. RT-PCR and second round PCR for gene amplification using specific primers, succeeding ultra-filtration and RNA isolation, was used to determine the presence of rotaviral RNA in water samples. The results show that rotaviral RNA was found in wastewater after the washing process, thus confirming an inadequate disinfecting effect of the examined laundering procedures.

  1. GRAMMATICAL ERRORS FOUND IN ARTICLES’ ABSTRACTS OF INDONESIAN SCHOLARLY JOURNALS

    Directory of Open Access Journals (Sweden)

    Indra Wulandari

    2014-11-01

    Full Text Available This study is aimed to know the grammatical errors found in the articles’ abstracts of scholarly journals published by one of Indonesian Islamic State Colleges in 2008-2010. The theory used to analyze the data in this case study is Burt and Kiparsky’s theory, namely Surface Strategy Taxonomy. This theory devides errors into errors of omission, errors of addition, errors of misformation and errors of misordering. This results of the study show that there are 172 items of grammatical errors. The most frequent type of grammatical error is omission with the total number is 72 items or 41.9%. The second is errors of misformation which consist of 57 items or 33.1%. The next is errors of addition (27 items or 15.7% and finally is errors of misordering as the least number of errors with 16 items or 9.3%

  2. Nontraumatic Fat Embolism Found Following Maternal Death after Cesarean Delivery

    Directory of Open Access Journals (Sweden)

    Tabitha Schrufer-Poland

    2015-04-01

    Full Text Available Introduction - Fat embolism is a rare form of nonthrombotic embolization. Limited literature exists regarding the diagnosis of fat embolism during the perinatal period. We present the first case of maternal death that resulted from nontraumatic fat embolization following Cesarean delivery. Case Description - A 29-year-old gravida 1 with a complex medical and surgical history underwent a primary Cesarean delivery at term. On postoperative day 2 the patient was found to be unresponsive. Despite resuscitative efforts, the patient succumbed. Autopsy findings were remarkable for diffuse pulmonary fat emboli. Furthermore, there was no histological evidence of either amniotic fluid embolism or thromboembolism. The primary cause of death was attributed to nontraumatic fat embolization. Discussion - Multiple risk factors may have contributed to the development of nontraumatic fat embolization in our patient. Obstetricians should maintain a high level of suspicion for nontraumatic fat embolization in cases of maternal respiratory decompression and sudden maternal mortality.

  3. Proposal for founding mistrustful quantum cryptography on coin tossing

    Science.gov (United States)

    Kent, Adrian

    2003-07-01

    A significant branch of classical cryptography deals with the problems which arise when mistrustful parties need to generate, process, or exchange information. As Kilian showed a while ago, mistrustful classical cryptography can be founded on a single protocol, oblivious transfer, from which general secure multiparty computations can be built. The scope of mistrustful quantum cryptography is limited by no-go theorems, which rule out, inter alia, unconditionally secure quantum protocols for oblivious transfer or general secure two-party computations. These theorems apply even to protocols which take relativistic signaling constraints into account. The best that can be hoped for, in general, are quantum protocols which are computationally secure against quantum attack. Here a method is described for building a classically certified bit commitment, and hence every other mistrustful cryptographic task, from a secure coin-tossing protocol. No security proof is attempted, but reasons are sketched why these protocols might resist quantum computational attack.

  4. The Founding Years of the International New Venture

    DEFF Research Database (Denmark)

    Rasmussen, Erik Stavnsager; Servais, Per; Madsen, Tage Koed

    2007-01-01

    Several studies have focused on International New Ventures; smaller, entrepreneurial firms which adopt a global focus from the beginning and operate in international markets from the earliest day of their establishment. In this paper we intend to focus on the founding years of the International New...... Ventures through the use of a large scale study of all types of industrial firms. This is supplemented with a large number of case studies of International New Ventures since 1997. Some preliminary conclusions are: When the International New Ventures are compared with other types of firms, large...... differences can be seen in their internationalization and in the development in the first three years. The complexity of the internationalization of the International New Ventures is e.g. high compared with other types of international firms....

  5. A small cohort of Island Southeast Asian women founded Madagascar.

    Science.gov (United States)

    Cox, Murray P; Nelson, Michael G; Tumonggor, Meryanne K; Ricaut, François-X; Sudoyo, Herawati

    2012-07-22

    The settlement of Madagascar is one of the most unusual, and least understood, episodes in human prehistory. Madagascar was one of the last landmasses to be reached by people, and despite the island's location just off the east coast of Africa, evidence from genetics, language and culture all attests that it was settled jointly by Africans, and more surprisingly, Indonesians. Nevertheless, extremely little is known about the settlement process itself. Here, we report broad geographical screening of Malagasy and Indonesian genetic variation, from which we infer a statistically robust coalescent model of the island's initial settlement. Maximum-likelihood estimates favour a scenario in which Madagascar was settled approximately 1200 years ago by a very small group of women (approx. 30), most of Indonesian descent (approx. 93%). This highly restricted founding population raises the possibility that Madagascar was settled not as a large-scale planned colonization event from Indonesia, but rather through a small, perhaps even unintended, transoceanic crossing.

  6. Microbiological Load of Edible Insects Found in Belgium.

    Science.gov (United States)

    Caparros Megido, Rudy; Desmedt, Sandrine; Blecker, Christophe; Béra, François; Haubruge, Éric; Alabi, Taofic; Francis, Frédéric

    2017-01-13

    Edible insects are gaining more and more attention as a sustainable source of animal protein for food and feed in the future. In Belgium, some insect products can be found on the market, and consumers are sourcing fresh insects from fishing stores or towards traditional markets to find exotic insects that are illegal and not sanitarily controlled. From this perspective, this study aims to characterize the microbial load of edible insects found in Belgium (i.e., fresh mealworms and house crickets from European farms and smoked termites and caterpillars from a traditional Congolese market) and to evaluate the efficiency of different processing methods (blanching for all species and freeze-drying and sterilization for European species) in reducing microorganism counts. All untreated insect samples had a total aerobic count higher than the limit for fresh minced meat (6.7 log cfu/g). Nevertheless, a species-dependent blanching step has led to a reduction of the total aerobic count under this limit, except for one caterpillar species. Freeze-drying and sterilization treatments on European species were also effective in reducing the total aerobic count. Yeast and mold counts for untreated insects were above the Good Manufacturing Practice limits for raw meat, but all treatments attained a reduction of these microorganisms under this limit. These results confirmed that fresh insects, but also smoked insects from non-European trades, need a cooking step (at least composed of a first blanching step) before consumption. Therefore, blanching timing for each studied insect species is proposed and discussed.

  7. Microbiological Load of Edible Insects Found in Belgium

    Directory of Open Access Journals (Sweden)

    Rudy Caparros Megido

    2017-01-01

    Full Text Available Edible insects are gaining more and more attention as a sustainable source of animal protein for food and feed in the future. In Belgium, some insect products can be found on the market, and consumers are sourcing fresh insects from fishing stores or towards traditional markets to find exotic insects that are illegal and not sanitarily controlled. From this perspective, this study aims to characterize the microbial load of edible insects found in Belgium (i.e., fresh mealworms and house crickets from European farms and smoked termites and caterpillars from a traditional Congolese market and to evaluate the efficiency of different processing methods (blanching for all species and freeze-drying and sterilization for European species in reducing microorganism counts. All untreated insect samples had a total aerobic count higher than the limit for fresh minced meat (6.7 log cfu/g. Nevertheless, a species-dependent blanching step has led to a reduction of the total aerobic count under this limit, except for one caterpillar species. Freeze-drying and sterilization treatments on European species were also effective in reducing the total aerobic count. Yeast and mold counts for untreated insects were above the Good Manufacturing Practice limits for raw meat, but all treatments attained a reduction of these microorganisms under this limit. These results confirmed that fresh insects, but also smoked insects from non-European trades, need a cooking step (at least composed of a first blanching step before consumption. Therefore, blanching timing for each studied insect species is proposed and discussed.

  8. Positive and Negative Themes Found in Sport-Related Films.

    Science.gov (United States)

    Wakefield, Hannah M; Olympia, Robert P; King, Tonya S; Wakefield, Bryan H; Weber, Chris J

    2017-06-01

    Sport participation is an important part of the development of children and adolescents in the United States. The objective of this study was to determine positive and negative themes found in a selected number of sport-related films. A total of 44 sport-related films were independently viewed and analyzed by four reviewers. The most common sports depicted were baseball (27%) and football (25%). The most common positive themes were positive interactions with the coach, positive interactions with family and friends, and positive interactions with teammates (2.04, 1.42, 1.2 mean events per hour). The most common negative themes were taunting/fighting/poor sportsmanship, negative interactions with the coach, and drinking/smoking/drug use (2.13, 1.10, 0.94 mean events per hour). In conclusion, the coviewing of sport films among pediatric athletes and their coaches, athletic trainers, and/or parents in order to focus on "teachable moments" may encourage the acquisition and development of positive themes and the avoidance and de-emphasis of negative themes.

  9. [The founding fathers of the International Union for Health Education].

    Science.gov (United States)

    Senault, R

    1991-03-01

    At the Fourteenth World Conference on Health Education in Helsinki in June 1991, a special ceremony will celebrate the fortieth anniversary of the founding of the International Union for Health Education. The Union was created following studies and discussions among delegates from thirty-five countries and representatives from fifteen non-governmental organizations (NGO), and in the presence of observers from WHO and UNESCO. The document creating the Union was signed at the French Ministry of Foreign Affairs on May 30, 1951. This article evokes the memory of the pioneers under whose authority the Union was formed and has developed. The leading thinkers in health education were the creators of a work still referred to today when we examine the history and evolution of the IUHE. Our pioneers were Jacques Parisot and Lucien Bivorel in France, Clair E. Turner in the United States of America, and Giovanni Canaperia in Italy. An English translation of this homage to the founders of the international Union for Health Education will appear as a publication made available at the Fourteenth International Conference on Health Education in Helsinki. It will also be available from the IUHE's Headquarters.

  10. Analyzing the Number of Varieties in Frequently Found Flows

    Science.gov (United States)

    Shomura, Yusuke; Watanabe, Yoshinori; Yoshida, Kenichi

    Abnormal traffic that causes various problems on the Internet, such as P2P flows, DDoS attacks, and Internet worms, is increasing; therefore, the importance of methods that identify and control abnormal traffic is also increasing. Though the application of frequent-itemset-mining techniques is a promising way to analyze Internet traffic, the huge amount of data on the Internet prevents such techniques from being effective. To overcome this problem, we have developed a simple frequent-itemset-mining method that uses only a small amount of memory but is effective even with the large volumes of data associated with broadband Internet traffic. Using our method also involves analyzing the number of distinct elements in the itemsets found, which helps identify abnormal traffic. We used a cache-based implementation of our method to analyze actual data on the Internet and demonstrated that such an implementation can be used to provide on-line analysis of data while using only a small amount of memory.

  11. Phthalic acid esters found in municipal organic waste

    DEFF Research Database (Denmark)

    Hartmann, Hinrich; Ahring, Birgitte Kiær

    2003-01-01

    ) in OFMSW was monitored in the influent and effluent of anaerobic thermophilic (55degreesC) and hyper-thermophilic CO (68degreesC) laboratory-scale reactor systems. In the thermophilic reactors with a hydraulic retention time (HRT) of W 15 days 38-70% of DBP was removed, but no consistent removal of DEHP...... was observed. However, after treatment of the effluent from the thermophilic reactor in a hyper-thermophilic digester (HRT: 5 days) 0 CO 34-53% of the DEHP content was removed and the DBP removal was increased to further 62-74%. Removal rates (k(h)) of DEHP and DBP were found to be 0.11-0.32 d(-1) and 0.......41-0.79 d(-1), which is much higher than in previous investigations. It can be concluded that the higher removal rates are due to the higher temperature and higher initial concentrations per kg dry matter. These results suggest that the limiting factor for DEHP degradation is the bioavailability, which...

  12. The Language Characteristics of Inscriptions Found at and around Celeia

    Directory of Open Access Journals (Sweden)

    Julijana Visočnik

    2007-12-01

    Full Text Available Errors attested in Celeian inscriptions are a reflection of Latin language that was actually spoken in everyday life by ordinary people. When studying Vulgar Latin, it is possible to observe the development of a language, which ended in Romance languages. Some attested mistakes are of a technical nature; but the greater part of them were made on account of the language development. Differences between the town and ager are expected: more errors can be found in ager and these are of a greater importance; in the town they are mostly of a marginal character. It can be concluded that the town – Celeia itself – was romanized sooner and more comprehensively. The analysis of the vocabulary and linguistic peculiarities on the inscriptions of Celeia and its adjacent areas confirms the important role of the town, which became the center of Romanization for southern Noricum . Due to the character of inscriptions in the town as in ager there can be seen phonetic, spelling and morphological errors. Syntactic and discourse specifics and those connected with vocabulary are nothing more than isolated examples written in those few inscriptions, which none the less exceed rigid form of abbreviations and basic data. Monophtongizations, writings of letter K instead of C, simplifications of double consonants and vowels appear most frequently. These can be considered to be basic changes that arose in the language and left traces there through centuries.

  13. The first Neanderthal tooth found North of the Carpathian Mountains

    Science.gov (United States)

    Urbanowski, Mikołaj; Socha, Paweł; Dąbrowski, Paweł; Nowaczewska, Wioletta; Sadakierska-Chudy, Anna; Dobosz, Tadeusz; Stefaniak, Krzysztof; Nadachowski, Adam

    2010-04-01

    An upper second permanent molar from a human was found alongside numerous tools of the Micoquian tradition and was excavated in Stajnia Cave, which is located over 100 km North of the Carpathian Mountains in southern Poland. The age of these finds has been established within a time-span of late Saalian to early Weichselian, most likely to OIS 5c or 5a, according to the palaeontological, geological, archaeological and absolute dating of the layer from which they were obtained. An examination of the morphology of the human molar indicates that this tooth exhibits many traits frequently occurring in Neanderthal upper molars. Although the occurrence of derived Neanderthal traits in the Stajnia molar cannot be firmly established because of degradation of its cusps, the presence of the above-mentioned features allows the assertion that this tooth belonged to a Neanderthal. The age of the Stajnia tooth and the archaeological context of this find also indicate that this molar is of Neanderthal origin.

  14. Buprenorphine infrequently found in fatal overdose in New York City.

    Science.gov (United States)

    Paone, Denise; Tuazon, Ellenie; Stajic, Marina; Sampson, Barbara; Allen, Bennett; Mantha, Shivani; Kunins, Hillary

    2015-10-01

    Buprenorphine is an opioid agonist medication that is both safe and effective in the treatment of opioid use disorders and the prevention of opioid overdoses. Despite this, media coverage has highlighted public concerns about the potential safety consequences of buprenorphine misuse and diversion. To address the possible contribution of buprenorphine to overdose mortality, we systematically tested post mortem blood specimens from decedents who had died of an unintentional drug overdoses in 2013. We retrospectively tested consecutive drug overdose cases that occurred from June through October 2013. Cases with available blood specimens were tested for buprenorphine and norbuprenorphine using liquid chromatography-tandem mass spectrometry. Toxicology results were linked to death certificates and case files from New York City Vital Statistics and New York City Office of the Chief Medical Examiner. Of the 98 unintentional drug overdose fatalities tested, only 2 (2.0%) tested positive for buprenorphine metabolites. All 98 unintentional fatalities involved multiple substances. Buprenorphine was infrequently found in drug overdose deaths in New York City. Since the safety and efficacy of buprenorphine are well documented, and overdoses resulting from buprenorphine treatment or diversion are very rare, facilitating access to buprenorphine treatment is strongly recommended. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  15. Characteristics of medication advertisements found in US women's fashion magazines.

    Science.gov (United States)

    Mongiovi, Jennifer; Clarke Hillyer, Grace; Basch, Corey H; Ethan, Danna; Hammond, Rodney

    2017-01-01

    Background: Although prescriptions are dispensed at discretion of medical professionals, many pharmaceutical companies use direct-to-consumer (DTC) advertising to increase sales. Over-the-counter (OTC) medications are similarly marketed. Methods: We examined the content of advertisements in 38 issues of 9 popular US women's fashion magazines. We evaluated target audience, health condition, product availability, message appeal, target to females, and mention of potential side effects and benefits. Results: Sixty total medication advertisements were identified, 58.3% (95% CI: 45.8, 70.8) for prescription products. In magazines targeted to non-Hispanic Whites, >65% of advertisements were for OTC medications whereas 80% (95% CI: 66.7, 94.5) of advertisements found in Black/Latina magazines were for prescription medications. The rational appeal was used most commonly in non-Hispanic White magazines (75.9%; 95% CI: 60.3, 91.5). Emotional appeal was featured more often in prescription advertisements magazines (60.0; 95% CI:43.8, 76.2) compared to OTC (8.0; 95% CI: -2.6, 18.6). Conclusion: Although emotional appeal may be effective for selling medication to women, it often does not completely inform consumers of potential risks.

  16. Found a USB stick? Go and infect your PC!

    CERN Multimedia

    Computer Security Team

    2012-01-01

    Err. Wait. Please no! USB sticks are not innocent little things. They can quickly mutate into malicious nasty beasts! Just in the recent past, at least two physics experiments were suffering as their control and data acquisition PCs, respectively, were infected by USB sticks holding malicious code. A bit longer ago, a series of laptops were infected at a 2008 computing conference as an infected USB stick made its tour around. Bad luck for those who ran a Windows operating system and inserted that stick…   So, you found a USB stick in the cafeteria? Take care. If this were a lollipop, you wouldn’t just pick it up and lick it, would you? So beware of USB sticks whose origin or previous usage you don’t know. They might infect your PC once plugged in. In order to be on the safe side, accept and share only USB sticks whose owner you trust. Run up-to-date anti-virus software on your PC, make sure that its operating system is patched...

  17. Quartz-like Crystals Found in Planetary Disks

    Science.gov (United States)

    2008-01-01

    NASA's Spitzer Space Telescope has, for the first time, detected tiny quartz-like crystals sprinkled in young planetary systems. The crystals, which are types of silica minerals called cristobalite and tridymite, can be seen close-up in the black-and-white insets (cristobalite is on the left, and tridymite on the right). The main picture is an artist's concept of a young star and its swirling disk of planet-forming materials. Cristobalite and tridymite are thought to be two of many planet ingredients. On Earth, they are normally found as tiny crystals in volcanic lava flows and meteorites from space. These minerals are both related to quartz. For example, if you were to heat the familiar quartz crystals often sold as mystical tokens, the quartz would transform into cristobalite and tridymite. Because cristobalite and tridymite require rapid heating and cooling to form, astronomers say they were most likely generated by shock waves traveling through the planetary disks. The insets are Scanning Electron Microscope pictures courtesy of George Rossman of the California Institute of Technology, Pasadena, Calif.

  18. Reinforcing effects of caffeine and theobromine as found in chocolate.

    Science.gov (United States)

    Smit, Hendrik J; Blackburn, Rachel J

    2005-08-01

    Although in a previous study we showed that caffeine and theobromine were the main psychopharmacologically active constituents in a 50-g bar of chocolate, mere activity does not guarantee a role in our liking for the food. Our aim was to see if liking for a drink repeatedly paired with these amounts of caffeine and theobromine would increase compared to a placebo-paired drink. Participants (n=64) consumed a 'novel' drink + treatment capsule on six non-consecutive mornings using a double-blind, placebo-controlled independent-sample design. Aspects of liking and intensity of various sensory descriptors for these drinks were measured at every drink collection. Treatment capsules contained either an ecologically relevant dose combination of 19-mg caffeine and 250-mg theobromine or a placebo. Liking for the drink paired with the methylxanthine-containing capsules increased over time compared to the placebo-paired drink. This highly significant effect was confirmed by subjective, retrospective changes in liking for the drink. Methylxanthines in amounts found in 50-g chocolate may well contribute to our liking for chocolate, especially to the more acquired taste for dark chocolate.

  19. Nurse executive transformational leadership found in participative organizations.

    Science.gov (United States)

    Dunham-Taylor, J

    2000-05-01

    The study examined a national sample of 396 randomly selected hospital nurse executives to explore transformational leadership, stage of power, and organizational climate. Results from a few nurse executive studies have found nurse executives were transformational leaders. As executives were more transformational, they achieved better staff satisfaction and higher work group effectiveness. This study integrates Bass' transformational leadership model with Hagberg's power stage theory and Likert's organizational climate theory. Nurse executives (396) and staff reporting to them (1,115) rated the nurse executives' leadership style, staff extra effort, staff satisfaction, and work group effectiveness using Bass and Avolio's Multifactor Leadership Questionnaire. Executives' bosses (360) rated executive work group effectiveness. Executives completed Hagberg's Personal Power Profile and ranked their organizational climate using Likert's Profile of Organizational Characteristics. Nurse executives used transformational leadership fairly often; achieved fairly satisfied staff levels; were very effective according to bosses; were most likely at stage 3 (power by achievement) or stage 4 (power by reflection); and rated their hospital as a Likert System 3 Consultative Organization. Staff satisfaction and work group effectiveness decreased as nurse executives were more transactional. Higher transformational scores tended to occur with higher educational degrees and within more participative organizations. Transformational qualities can be enhanced by further education, by achieving higher power stages, and by being within more participative organizations.

  20. Zout en hypertensie : verlaging op populatieniveau geoorloofd?

    NARCIS (Netherlands)

    Seidell, Jaap C; Halberstadt, J.

    2014-01-01

    The average salt intake in the Netherlands is well above the nationally recommended maximum intake of 6 grams per day. People with high intakes, especially if they have hypertension or type 2 diabetes mellitus and/or are older than 50 years of age are advised to lower their salt intake. Decreasing

  1. Have Two Lonely Trans-Neptunian Objects Found Each Other?

    Science.gov (United States)

    Kohler, Susanna

    2017-08-01

    Who says theres no romance in the outer solar system? A new study has identified 2004 TT357 as a body that may be made up of two separate objects in contact with each other.Identification ChallengesA large fraction of both the near and distant small bodies in our solar system are predicted to be in binary systems. When these systems are nearby and have large separations, we can use telescopes like Hubble to observe them and identify the two separate components. But when binaries are far away and have small separations, Hubble doesnt have the resolution to tell that theyre not a single object.Comet 67P/ChuryumovGerasimenko is an example of a suspected contact binary in the inner solar system. [ESA]Contact binaries are objects consisting of two lobes in contact with each other, like the bi-lobed, peanut-shaped comet 67P/ChuryumovGerasimenko. These systems occur when two objects gravitate toward each other until the point where they touch.Though Hubble cant recognize distant contact binaries because the components are too close together, we can potentially identify them from their characteristic light curves. But this is a challenging process, and so far weve only found one confirmed trans-Neptunian-object (TNO) contact binary and one candidate despite predictions that 1030% of TNOs could be contact binaries.Now, new observations from the 4.3-m Lowell Observatory Discovery Channel Telescope, presented in a study led by Audrey Thirouin (Lowell Observatory), have resulted in the identification of a potential new TNO contact binary.Light curve for 2004 TT357. The double-peaked light curve (with a rotational period of 7.79 hr) is plotted over two cycles. [Adapted from Thirouin et al. 2017]Changing Brightness2004 TT357 is a TNO in our distant solar system orbiting with a semimajor axis of 55 AU. Thirouin and collaborators observations of this object allowed them to construct a lightcurve for 2004 TT357 that revealed a 7.8-hour period and a significant amplitude variation

  2. Statistical analyses support power law distributions found in neuronal avalanches.

    Directory of Open Access Journals (Sweden)

    Andreas Klaus

    Full Text Available The size distribution of neuronal avalanches in cortical networks has been reported to follow a power law distribution with exponent close to -1.5, which is a reflection of long-range spatial correlations in spontaneous neuronal activity. However, identifying power law scaling in empirical data can be difficult and sometimes controversial. In the present study, we tested the power law hypothesis for neuronal avalanches by using more stringent statistical analyses. In particular, we performed the following steps: (i analysis of finite-size scaling to identify scale-free dynamics in neuronal avalanches, (ii model parameter estimation to determine the specific exponent of the power law, and (iii comparison of the power law to alternative model distributions. Consistent with critical state dynamics, avalanche size distributions exhibited robust scaling behavior in which the maximum avalanche size was limited only by the spatial extent of sampling ("finite size" effect. This scale-free dynamics suggests the power law as a model for the distribution of avalanche sizes. Using both the Kolmogorov-Smirnov statistic and a maximum likelihood approach, we found the slope to be close to -1.5, which is in line with previous reports. Finally, the power law model for neuronal avalanches was compared to the exponential and to various heavy-tail distributions based on the Kolmogorov-Smirnov distance and by using a log-likelihood ratio test. Both the power law distribution without and with exponential cut-off provided significantly better fits to the cluster size distributions in neuronal avalanches than the exponential, the lognormal and the gamma distribution. In summary, our findings strongly support the power law scaling in neuronal avalanches, providing further evidence for critical state dynamics in superficial layers of cortex.

  3. Efficacy and safety of ingredients found in preworkout supplements.

    Science.gov (United States)

    Eudy, Anne E; Gordon, Lindsay L; Hockaday, Brandon C; Lee, Daniel A; Lee, Vivianne; Luu, Daniel; Martinez, Carlos A; Ambrose, Peter J

    2013-04-01

    Published evidence on common ingredients of "energy drinks" and other dietary supplements widely used by consumers in hopes of enhancing athletic performance is reviewed. Preworkout products- unregulated dietary supplements- typically contain "proprietary blends" of multiple ingredients, including caffeine, dimethylamylamine, creatine, arginine, β-alanine, taurine, and phosphates. While some dietary supplement labels instruct consumers to seek the advice of a health care professional before using the products, the labels usually do not disclose all ingredients or their precise amounts, and evidence to support the purported performance-enhancing benefits is generally lacking. There is limited evidence to support the use of some preworkout supplement ingredients. For example, in one small placebo-controlled study (n = 12), the use of the energy drink Red Bull (containing caffeine and taurine) 40 minutes before a simulated cycling time trial appeared to provide a meaningful ergogenic benefit; in another small study (n = 12), the use of a similar caffeine-containing product (Redline) by strength-trained athletes was found to improve reaction time, energy, and mental focus relative to placebo use. However, published evidence on the use of the other ingredients listed above is scant, inconclusive, or conflicting. Adverse effects reported in association with preworkout supplements include gastrointestinal symptoms, cardiac arrhythmia, blood pressure increases, and potential effects on lipids and blood glucose. Although evidence exists to support the performance-enhancement efficacy of some preworkout ingredients as standalone agents, published data on combination products are scant, inconclusive, or conflicting. The safety of these products may be compromised if users consume larger-than-recommended amounts or use more than one product.

  4. Genetic characterization of Porcine Circovirus 2 found in Malaysia

    Science.gov (United States)

    2011-01-01

    Background Porcine circovirus type 2 is the primary etiological agent associated with a group of complex multi-factorial diseases classified as Porcine Circovirus Associated Diseases (PCVAD). Sporadic cases reported in Malaysia in 2007 caused major economic losses to the 2.2 billion Malaysian ringgit (MYR) (approximately 0.7 billion US dollar) swine industry. The objective of the present study was to determine the association between the presence of PCV2 and occurrences of PCVAD. Results This study showed that 37 out of 42 farms sampled were positive for PCV2 using PCR screening. Thirteen whole genome of PCV2 isolates from pigs with typical PCVAD symptoms were successfully sequenced. These isolates shared 98.3-99.2% similarities with sequences of isolates from the Netherlands. All thirteen isolates fell into the same clade as PCV2b isolates from other countries. Amino acid sequence analysis of the putative capsid protein (ORF2) of the PCV2 revealed that there are three clusters found in Malaysia, namely cluster 1C and 1A/1B. Of interest, three of the isolates (isolates Mal 005, Mal 006 and Mal 010) had a proline substitution for arginine or isoleucine encoded at nt. position 88-89. Eight of the isolates had mutations at the C terminus of the putative capsid protein suggestive of higher pathogenicity which may account for the high reports of PCVAD clinical symptoms in 2007. Conclusion Phylogenetic study suggests that there may be a link between movements of animals by import of breeders into the country being the route of entry of the virus. While it is not possible to eradicate the virus from commercial pigs, the swine industry in Malaysia can be safeguarded by control measures implemented throughout the country. These measures should include improved biosecurity, disease surveillance; vaccination as well as enforcement of regulations formulated to control and prevent the spread of this disease on a national scale. PMID:21914166

  5. Yoga is found hazardous to the meniscus for Chinese

    Directory of Open Access Journals (Sweden)

    ZHU Jun-kun

    2012-06-01

    Full Text Available 【Abstract】Objective: Yoga is becoming more and more popular in the female society while the concomitant sports injury is seldom mentioned. Many clinicians have noted that yoga may result in knee problems, which though requires more researches to corroborate. This investigation was conducted to ascertain the relationship between yoga and meniscus injury as well as the extent of impairment ac-cording to variant yoga practice periods. Methods: Totally 819 women aged 20-49 years who practiced yoga or other popular sports including badminton, jogging, climbing hills, etc for at least one hour per day were selected to participate in this research. These subjects were required to complete a questionnaire and receive relevant physical examination. Magnetic resonance (MR scan of the knee was recommended for the suspicious subjects for ultimate diagnosis. The subject with abnormal meniscus MR signals was defined as a case and matched with two con-trols in terms of age and body mass index (BMI. Altogether there were 273 cases and 546 controls. The nested case-control model was adopted to assess the risk of meniscus injury between variant exposures in practicing yoga and several other popular sports. Moreover, the 181 yoga sub-jects were subdivided into three groups according to differ-ent exercise durations, followed by further analysis with the variables of age, BMI and Lysholm score. Results: Yoga was found associated with a higher risk (P=0.008, OR=1.621 of meniscus injury compared with badminton, jogging and climbing hills. The three yoga sub-groups showed statistical difference between each other in terms of Lysholm score (P=0.027 and BMI (P=0.003. The subjects with longer-term yoga practice had lighter weight but lower Lysholm scores. Conclusions: Yoga perhaps exerts destructive impact on the meniscus for Chinese women, yet it needs further verifications. Furthermore, the female yoga players with longer exercise duration are more susceptible to

  6. The Founding of the Brookhaven National Laboratory - Associated Universities, Inc.

    Energy Technology Data Exchange (ETDEWEB)

    BROOKHAVEN NATIONAL LABORATORY

    1948-01-15

    report, the final report of the Columbia University contracts which financed the first year of development of the Brookhaven National Laboratory, summarizes the successive stages of organization, the considerations underlying some of its basic policies, and the methods of attack on the general problems encountered in founding the Laboratory. During the preliminary period of planning covered by this report, from early January 1946 until January 31, 1947, Columbia paid for salaries, office space, travel and consultant fees, and other expenses incurred by the new organization. These funds were provided through contracts held by the university with the War Department and later with the AEC. A supplement, dated April 3, to a contract with the War Department, W-7405-eng-50, covered the work to June 30, 1946. Contract W-3l-l09-eng-15, with the War Department, covered the work to December 31, 1946. On January 1, 1947, this contract was converted to a contract with the AEC, AT-30-1-GEN-71, which lasted until January 31, 1947. After this date a Letter Contract, AT-30-2-GEN-16, dated January 7, 1947, between AUI and the AEC, permitted AUI to assume all expenses.

  7. Found Money.

    Science.gov (United States)

    Kennedy, Mike

    2000-01-01

    Discusses the alternative funding avenues school districts have used to support facility construction and improvements when tax levies and state aid are not enough. Acquiring donations, creating lease-purchase agreements, and using tax increment financing are highlighted. (GR)

  8. FOUNDING SOCIETIES

    National Research Council Canada - National Science Library

    Henry Petroski

    2008-01-01

      [...] with the development of the railroads, the telegraph, and other marvels of the Industrial Revolution, a civil engineering society did not provide a sufficiently broad umbrella under which mining...

  9. 32 CFR 552.16 - Real estate claims founded upon contract.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 3 2010-07-01 2010-07-01 true Real estate claims founded upon contract. 552.16... Real Estate Claims Founded Upon Contract § 552.16 Real estate claims founded upon contract. (a) Purpose... interest in real estate for which compensation must be made according to the Fifth Amendment to the...

  10. Daniel Wildmann: Der veränderbare Körper. Jüdische Turner, Männlichkeit und das Wiedergewinnen von Geschichte in Deutschland um 1900. Tübingen: Mohr Siebeck Verlag 2009.

    Directory of Open Access Journals (Sweden)

    Martin Lücke

    2010-03-01

    Full Text Available In seiner körpergeschichtlichen Studie widmet sich Daniel Wildmann nationaljüdischen Turnvereinen in Deutschland im Zeitraum von 1898 bis 1921. Er zeichnet nach, wie sich der Entwurf eines jüdischen Turnkollektivs in politischen Auseinandersetzungen im Spannungsfeld von Zionismus und Antisemitismus im deutschen Kaiserreich verorten lässt und an welche medizinischen Diskurse die Debatten um eine körperlich-therapeutische Wirkung von Turnen anknüpften. Schwerpunkt seiner Arbeit ist jedoch das Herausarbeiten der geschlechtlichen Kodierung der jüdischen turnenden Männer- und Frauenkörper. Hier zeigt Wildmann, dass insbesondere eine eigensinnige Aneignung und Umdeutung von Vorstellungen der jüdischen Antike sowie Körperbilder einer Offiziers-Männlichkeit die Vorstellung von idealer jüdischer Männlichkeit prägten.In his study, which is informed by discourses on the history of the body, Daniel Wildmann examines national Jewish gymnastics clubs in Germany during the period from 1898 to 1921. He traces the manner in which we can locate the model of a Jewish gymnastics collective within the political debates found in the field of tension between Zionism and anti-Semitism during the German empire. Further, he pursues the question as to which medical discourses and debates connect to the physical-therapeutic effects of gymnastics. The focus of his work is, however, to address the gendered coding of Jewish gymnasts’ bodies, both male and female. Here, Wildmann shows that the conception of an ideal Jewish masculinity is determined in particular by a persistent appropriation and reinterpretation of ideas found in Jewish antiquity as well as masculine body images perpetuated by officers.

  11. Ulrike Auga, Claudia Bruns, Dorothea Dornhof, Gabriele Jähnert (Hg.: Dämonen, Vamps und Hysterikerinnen. Geschlechter- und Rassenfigurationen in Wissen, Medien und Alltag um 1900. Bielefeld: transcript Verlag 2011.

    Directory of Open Access Journals (Sweden)

    Annette Kliewer

    2012-12-01

    Full Text Available In der Festschrift zum 65. Geburtstag von Christina von Braun widmen sich ehemalige Studierende der Kulturwissenschaftlerin der Krise der Kultur nach der Jahrhundertwende um 1900 sowie dem Phänomen des ‚Abnormen‘, wie es sich etwa in Konstruktionen von Vamps, Perversen und Primitiven findet. In den Beiträgen werden dabei Themen aus so unterschiedlichen Bereichen wie Alltag, Medien (u. a. zu Filmen von Murnau und Lubitsch, Wissenschaft (u. a. zu Freud und Haeckel, Religion und Kunst (u. a. zum Marquis de Sade und zu Stefan Zweig aufgegriffen.In this Festschrift commemorating Christina von Braun’s 65th birthday, former students of the cultural scientist dedicate themselves to the crisis of culture after the turn of the century around 1900 and to the phenomenon of the ‘abnormal,’ as it can, for example, be found in constructions of vamps, perverts, and primitives. The articles discuss topics from a very diverse range of realms such as everyday life, media (films by Murnau and Lubitsch, among others, academia (e.g. Freud and Haeckel, religion and art (Marquis de Sade and Stefan Zweig, among others.

  12. The 16 most common fossil groups from Danian found in Faxe Quarry

    DEFF Research Database (Denmark)

    Lauridsen, Bodil Wesenberg

    2009-01-01

    Twelve folders dealing with the 16 most common fossil groups from Danian found in Faxe Quarry. The folders are for sale at the museum and designated for visitor......Twelve folders dealing with the 16 most common fossil groups from Danian found in Faxe Quarry. The folders are for sale at the museum and designated for visitor...

  13. Differential Allergy Induction by Molds Found in Water-Damaged Homes

    Science.gov (United States)

    Abstract: We compared the allergy induction potential of high concentration molds found in water-damaged homes and molds found more universally to house dust mite (HDM) in our mouse allergy/asthma model. Female BALB/c mice received 1 or 4 exposures by intratracheal aspiration of ...

  14. 38 CFR 12.24 - Operation of lost and found service.

    Science.gov (United States)

    2010-07-01

    ... close of business. Individuals claiming found articles will furnish complete identification and satisfy... custodian. VA Form 3771, Record of Lost or Found Article, will be used for recording articles of any... articles and to recover items which have been reported lost. Currency, including readily negotiable...

  15. 19 CFR 134.51 - Procedure when importation found not legally marked.

    Science.gov (United States)

    2010-04-01

    ... SECURITY; DEPARTMENT OF THE TREASURY COUNTRY OF ORIGIN MARKING Articles Found Not Legally Marked § 134.51 Procedure when importation found not legally marked. (a) Notice to mark or redeliver. When articles or... on Customs Form 4647 to arrange with the port director's office to properly mark the article or...

  16. A History of the Founding and Early Development of the "Journal of School Psychology"

    Science.gov (United States)

    Fagan, Thomas K.; Jack, Sabrina L.

    2012-01-01

    Historical aspects of the founding and early development of the "Journal of School Psychology" are discussed. Emphases are placed on the first decade of the journal, the factors in its founding and development, persons who have served as editors and members of the editorial boards and corporate leadership, and the journal's changing formats. The…

  17. Pesticides for apicultural and/or agricultural application found in Belgian honey bee wax combs

    OpenAIRE

    Ravoet, Jorgen; Reybroeck, Wim; de Graaf, Dirk

    2015-01-01

    In a Belgian pilot study honey bee wax combs from ten hives were analyzed on the presence of almost 300 organochlorine and organophosphorous compounds by LC?MS/MS and GC?MS/MS. Traces of 18 pesticides were found and not a single sample was free of residues. The number of residues found per sample ranged from 3 to 13, and the pesticides found could be categorized as (1) pesticides for solely apicultural (veterinary) application, (2) pesticides for solely agricultural (crop protection) applicat...

  18. Nest Relocation and Colony Founding in the Australian Desert Ant, Melophorus bagoti Lubbock (Hymenoptera: Formicidae

    Directory of Open Access Journals (Sweden)

    Patrick Schultheiss

    2010-01-01

    Full Text Available Even after years of research on navigation in the Red Honey Ant, Melophorus bagoti, much of its life history remains elusive. Here, we present observations on nest relocation and the reproductive and founding stages of colonies. Nest relocation is possibly aided by trail laying behaviour, which is highly unusual for solitary foraging desert ants. Reproduction occurs in synchronised mating flights, which are probably triggered by rain. Queens may engage in multiple matings, and there is circumstantial evidence that males are chemically attracted to queens. After the mating flight, the queens found new colonies independently and singly. Excavation of these founding colonies reveals first insights into their structure.

  19. A study in the founding of applied behavior analysis through its publications.

    Science.gov (United States)

    Morris, Edward K; Altus, Deborah E; Smith, Nathaniel G

    2013-01-01

    This article reports a study of the founding of applied behavior analysis through its publications. Our methods included hand searches of sources (e.g., journals, reference lists), search terms (i.e., early, applied, behavioral, research, literature), inclusion criteria (e.g., the field's applied dimension), and (d) challenges to their face and content validity. Our results were 36 articles published between 1959 and 1967 that we organized into 4 groups: 12 in 3 programs of research and 24 others. Our discussion addresses (a) limitations in our method (e.g., the completeness of our search), (b) challenges to the validity of our methods and results (e.g., convergent validity), and (c) priority claims about the field's founding. We conclude that the claims are irresolvable because identification of the founding publications depends significantly on methods and because the field's founding was an evolutionary process. We close with suggestions for future research.

  20. Autoinducer-2 activity produced by bacteria found in smear of surface ripened cheeses

    DEFF Research Database (Denmark)

    Gori, Klaus; Moslehi Jenabian, Saloomeh; Purrotti, Micol

    2011-01-01

    Bacterial strains of the species Arthrobacter nicotianae, Corynebacterium ammoniagenes, Corynebacterium casei, Microbacterium barkeri, Microbacterium gubbeenense and Staphylococcus equorum subsp. linens, all isolated from the smear of surface ripened cheeses, were found to possess autoinducer-2 (AI...

  1. Prevalence of taurodontism found in radiographic dental examination of 1,200 young adult Israeli patients.

    Science.gov (United States)

    Shifman, A; Chanannel, I

    1978-07-01

    The prevalence of taurodontism was studied radiographically in 1,200 young adult Israeli patients. In order to differentiate taurodont teeth from normal teeth, three types of taurodontism (meso-, hypo- and hypertaudodontism) were defined in biometric terms, using radiographic features of molar morphology. All three types according to Shaw's classification were seen. Taurodontism was found to occur in 5.6% of 1,200 individuals and in 1.5% of the 10,204 molar teeth examined. The mandibular second molar was found to be the most prone, being involved in two thirds of all cases found. Hypertaurodontism was found only in three cases, in the third molars. The conditions was seen to involve single and multiple teeth, both unilaterally and bilaterally, with the latter being most predominant.

  2. South Africa: ANC Youth League President found guilty of hate speech.

    Science.gov (United States)

    Sinclair, Kelly

    2010-06-01

    On 15 March 2010, the Johannesburg Equality Court found African National Congress (ANC) Youth League President Julius Malema guilty of hate speech and harassment for his comments regarding rape survivors.

  3. Possibly Active Persistent Thymus Found in a Human Adult Cadaver – A Morpho-histological Study

    OpenAIRE

    Nayak SB; Kumar N; Aithal AP; Shetty SD; Rao SS; Guru A

    2016-01-01

    Thymus is a bilobed organ usually situated in the superior mediastinum. Thymus is normally active until puberty and as age advances it undergoes considerable fibro-fatty degeneration and is replaced by fatty tissue. We found a persistent thymus in an adult male cadaver aged 70 years approximately. It apparently looked healthy. Hence the objective of this study was to know the morpho-histology of a persistent human thymus gland. Associated with this we also found a concurrent absence of isthmu...

  4. Genomic Identification of Founding Haplotypes Reveals the History of the Selfing Species Capsella rubella

    Science.gov (United States)

    Brandvain, Yaniv; Slotte, Tanja; Hazzouri, Khaled M.; Wright, Stephen I.; Coop, Graham

    2013-01-01

    The shift from outcrossing to self-fertilization is among the most common evolutionary transitions in flowering plants. Until recently, however, a genome-wide view of this transition has been obscured by both a dearth of appropriate data and the lack of appropriate population genomic methods to interpret such data. Here, we present a novel population genomic analysis detailing the origin of the selfing species, Capsella rubella, which recently split from its outcrossing sister, Capsella grandiflora. Due to the recency of the split, much of the variation within C. rubella is also found within C. grandiflora. We can therefore identify genomic regions where two C. rubella individuals have inherited the same or different segments of ancestral diversity (i.e. founding haplotypes) present in C. rubella's founder(s). Based on this analysis, we show that C. rubella was founded by multiple individuals drawn from a diverse ancestral population closely related to extant C. grandiflora, that drift and selection have rapidly homogenized most of this ancestral variation since C. rubella's founding, and that little novel variation has accumulated within this time. Despite the extensive loss of ancestral variation, the approximately 25% of the genome for which two C. rubella individuals have inherited different founding haplotypes makes up roughly 90% of the genetic variation between them. To extend these findings, we develop a coalescent model that utilizes the inferred frequency of founding haplotypes and variation within founding haplotypes to estimate that C. rubella was founded by a potentially large number of individuals between 50 and 100 kya, and has subsequently experienced a twenty-fold reduction in its effective population size. As population genomic data from an increasing number of outcrossing/selfing pairs are generated, analyses like the one developed here will facilitate a fine-scaled view of the evolutionary and demographic impact of the transition to self

  5. Novel Field-Induced Transitions Found in spin Systems on Pyrochlore Lattices

    OpenAIRE

    植田, 浩明

    2011-01-01

    We have investigated magnetic properties of two series of spin systems on pyrochlore lattices, chromium spinels and pyrochlore fluorides with 3d transition metal ions. For chromium spinels, we found novel field-induced magnetic phases with three-up and one-down spin arrangement. This type of magnetic structures are stabilized with a help of lattice distortions. Similar field-induced phase is found in a pyrochlore fluoride

  6. Elucidation of bacteria found in car interiors and strategies to reduce the presence of potential pathogens.

    Science.gov (United States)

    Stephenson, Rachel E; Gutierrez, Daniel; Peters, Cindy; Nichols, Mark; Boles, Blaise R

    2014-01-01

    The human microbiome is influenced by a number of factors, including environmental exposure to microbes. Because many humans spend a large amount of time in built environments, it can be expected that the microbial ecology of these environments will influence the human microbiome. In an attempt to further understand the microbial ecology of built environments, the microbiota of car interiors was analyzed using culture dependent and culture independent methods. While it was found that the number and type of bacteria varied widely among the cars and sites tested, Staphylococcus and Propionibacterium were nearly always the dominant genera found at the locations sampled. Because Staphylococcus is of particular concern to human health, the characteristics of this genus found in car interiors were investigated. Staphylococcus epidermidis, S. aureus, and S. warnerii were the most prevalent staphylococcal species found, and 22.6% of S. aureus strains isolated from shared community vehicles were resistant to methicillin. The reduction in the prevalence of pathogenic bacteria in cars by using silver-based antimicrobial surface coatings was also evaluated. Coatings containing 5% silver ion additives were applied to steering wheels, placed in cars for five months and were found to eliminate the presence of culturable pathogenic bacteria recovered from these sites relative to controls. Together, these results provide new insight into the microbiota found in an important built environment, the automobile, and potential strategies for controlling the presence of human pathogens.

  7. Was bioethics founded on historical and conceptual mistakes about medical paternalism?

    Science.gov (United States)

    McCullough, Laurence B

    2011-02-01

    Bioethics has a founding story in which medical paternalism, the interference with the autonomy of patients for their own clinical benefit, was an accepted ethical norm in the history of Western medical ethics and was widespread in clinical practice until bioethics changed the ethical norms and practice of medicine. In this paper I show that the founding story of bioethics misreads major texts in the history of Western medical ethics. I also show that a major source for empirical claims about the widespread practice of medical paternalism has been misread. I then show that that bioethics based on its founding story deprofessionalizes medical ethics. The result leaves the sick exposed to the predatory power of medical practitioners and healthcare organizations with only their autonomy-based rights to non-interference, expressed in contracts, to protect them. The sick are stripped of the protection afforded by a professional, fiduciary relationship of physicians to their patients. Bioethics based on its founding story reverts to the older model of a contractual relationship between the sick and medical practitioners not worthy of intellectual or moral trust (because such trust cannot be generated by what I call 'deprofessionalizing bioethics'). On closer examination, bioethics based on its founding story, ironically, eliminates paternalism as a moral category in bioethics, thus causing bioethics to collapse on itself because it denies one of the necessary conditions for medical paternalism. Bioethics based on its founding story should be abandoned. © 2010 Blackwell Publishing Ltd.

  8. Geographic origin is not supported by the genetic variability found in a large living collection of Jatropha curcas with accessions from three continents.

    Science.gov (United States)

    Maghuly, Fatemeh; Jankowicz-Cieslak, Joanna; Pabinger, Stephan; Till, Bradley J; Laimer, Margit

    2015-04-01

    Increasing economic interest in Jatropha curcas requires a major research focus on the genetic background and geographic origin of this non-edible biofuel crop. To determine the worldwide genetic structure of this species, amplified fragment length polymorphisms, inter simple sequence repeats, and novel single nucleotide polymorphisms (SNPs) were employed for a large collection of 907 J. curcas accessions and related species (RS) from three continents, 15 countries and 53 regions. PCoA, phenogram, and cophenetic analyses separated RS from two J. curcas groups. Accessions from Mexico, Bolivia, Paraguay, Kenya, and Ethiopia with unknown origins were found in both groups. In general, there was a considerable overlap between individuals from different regions and countries. The Bayesian approach using STRUCTURE demonstrated two groups with a low genetic variation. Analysis of molecular varience revealed significant variation among individuals within populations. SNPs found by in silico analyses of Δ12 fatty acid desaturase indicated possible changes in gene expression and thus in fatty acid profiles. SNP variation was higher in the curcin gene compared to genes involved in oil production. Novel SNPs allowed separating toxic, non-toxic, and Mexican accessions. The present study confirms that human activities had a major influence on the genetic diversity of J. curcas, not only because of domestication, but also because of biased selection. © 2015 The Authors. Biotechnology Journal published by Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

  9. Two novel rare variants of APOA5 gene found in subjects with severe hypertriglyceridemia.

    Science.gov (United States)

    Pisciotta, Livia; Fresa, Raffaele; Bellocchio, Antonella; Guido, Virgilia; Priore Oliva, Claudio; Calandra, Sebastiano; Bertolini, Stefano

    2011-11-20

    Common variants of APOA5 gene affect plasma triglyceride (TG) in the population and a number of rare variants APOA5 have been reported in individuals with hypertriglyceridemia (HTG). APOA5 was analysed in 98 HTG individuals (plasma TG >9 mmol/L) in whom no mutations in LPL and APOC2 had been found. Two patients were found to be heterozygous for two novel APOA5 variants. The first variant (p.L253P) was identified in an obese male who consumed a diet rich in fat and simple sugars. He was also a carrier in trans of the common TG-raising p.S19W SNP (5*3 haplotype). The second variant (c.295-297 del GAG, p.E99 del) was found in a lean male with no life style or metabolic factors known to affect plasma TG. He was a carrier in trans of the TG-raising 5*2 haplotype and was homozygous for the rare c.1337T allele of a SNP of GCKR gene. No mutations in other genes affecting plasma TG (LMF1 and GPIHBP1) were found in these patients. These APOA5 variants, resulted to be deleterious in silico, were not found in 350 control subjects. These novel APOA5 variants predispose to HTG in combination with other genetic or nutritional factors. Copyright © 2011 Elsevier B.V. All rights reserved.

  10. Intra-Diegetic Cameras as Cinematic Actor Assemblages in Found Footage Horror Cinema

    DEFF Research Database (Denmark)

    Rødje, Kjetil

    2017-01-01

    that comprises what is commonly known as human actors as well as material entities that play an active part in motion picture images. The use of intra-diegetic cameras in contemporary found footage horror films constitutes a particular case of such cinematic actor assemblages. Through a dynamic relational...... performance, cameras here take on roles as active agents with the potential to affect other elements within the images as well as the films’ audiences. In found footage horror the assemblage mode of operation creates suspense, since the vulnerability of the camera threatens the viewer's access to the depicted...... events. While human characters and individual entities making up the camera assemblage are disposable, the recording is not. Found footage horror crucially hinges upon the survival of the footage. I will further suggest that these films allow filmmakers to experiment with the acting capabilities of intra...

  11. Found Performance”: Towards a Musical Methodology for Exploring the Aesthetics of Care

    Science.gov (United States)

    2017-01-01

    Concepts of performance in fine art reflect key processes in music therapy. Music therapy enables practitioners to reframe patients as performers, producing new meanings around the clinical knowledge attached to medical histories and constructs. In this paper, music therapy practices are considered in the wider context of art history, with reference to allied theories from social research. Tracing a century in art that has revised the performativity of found objects (starting with Duchamp’s “Fountain”), and of found sound (crystallised by Cage’s 4′ 33) this paper proposes that music therapy might be a pioneer methodology of “found performance”. Examples from music therapy and contemporary socially engaged art practices are brought as potential links between artistic methodologies and medical humanities research, with specific reference to notions of Aesthetics of Care. PMID:28926991

  12. Found Performance”: Towards a Musical Methodology for Exploring the Aesthetics of Care

    Directory of Open Access Journals (Sweden)

    Stuart Wood

    2017-09-01

    Full Text Available Concepts of performance in fine art reflect key processes in music therapy. Music therapy enables practitioners to reframe patients as performers, producing new meanings around the clinical knowledge attached to medical histories and constructs. In this paper, music therapy practices are considered in the wider context of art history, with reference to allied theories from social research. Tracing a century in art that has revised the performativity of found objects (starting with Duchamp’s “Fountain”, and of found sound (crystallised by Cage’s 4′ 33 this paper proposes that music therapy might be a pioneer methodology of “found performance”. Examples from music therapy and contemporary socially engaged art practices are brought as potential links between artistic methodologies and medical humanities research, with specific reference to notions of Aesthetics of Care.

  13. "Found Performance": Towards a Musical Methodology for Exploring the Aesthetics of Care.

    Science.gov (United States)

    Wood, Stuart

    2017-09-18

    Concepts of performance in fine art reflect key processes in music therapy. Music therapy enables practitioners to reframe patients as performers, producing new meanings around the clinical knowledge attached to medical histories and constructs. In this paper, music therapy practices are considered in the wider context of art history, with reference to allied theories from social research. Tracing a century in art that has revised the performativity of found objects (starting with Duchamp's "Fountain"), and of found sound (crystallised by Cage's 4' 33) this paper proposes that music therapy might be a pioneer methodology of "found performance". Examples from music therapy and contemporary socially engaged art practices are brought as potential links between artistic methodologies and medical humanities research, with specific reference to notions of Aesthetics of Care.

  14. A physical match of a metallic chip found on a bolt cutters' blade.

    Science.gov (United States)

    Finkelstein, Nir; Volkov, Nikolai; Novoselsky, Yehuda; Tsach, Tsadok

    2015-05-01

    Bolt cutters are known as devices which are used for cutting hard objects and rigid materials such as padlocks and bars. They are commonly used in instances of forced entries. In this case study, a bolt cutter was found in the car of two suspects in a grocery burglary. This study indicates how the presence of a small metallic chip found on a suspected bolt cutter can prove that the tool was used in the crime scene. During the initial examination, a metallic chip from the cut shackle padlock was found stuck to one of the bolt cutters' blades. By comparing the metallic chip's microscopic edge and the breaking (fracture) line of the padlock's shackle, a full physical match was noticed. We wish to report here how residue, even the smallest, can be used to link burglary tools to a crime scene with a high level of certainty. © 2015 American Academy of Forensic Sciences.

  15. Incidentally found and unexpected tumors discovered by MRI examination for temporomandibular joint arthrosis

    Energy Technology Data Exchange (ETDEWEB)

    Yanagi, Yoshinobu; Asaumi, Jun-ichi E-mail: asaumi@md.okayama-u.ac.jp; Maki, Yuu; Murakami, Jun; Hisatomi, Miki; Matsuzaki, Hidenobu; Konouchi, Hironobu; Honda, Yosutoshi; Kishi, Kanji

    2003-07-01

    We examined the frequency of incidentally found or unexpected tumors discovered at the time of magnetic resonance imaging (MRI) examinations in the temporomandibular joint (TMJ) region for patients with suspicion of TMJ arthrosis. Five MR images (T1-weighted transverse scout image and proton density and T2-weighted oblique sagittal images at the open and closed mouth) were acquired. In 2776 MRI examinations of TMJ arthrosis, two tumors were discovered. They consisted of an adenoid cystic carcinoma in the deep portion of the parotid gland, and a malignant tumor extending from the infratemporal fossa to the parapharyngeal space. The rate of incidentally founded or unexpected tumors in TMJ examinations was low (0.072%), but the two tumors found were malignant tumors, and therefore, scout image should be carefully examined, not only used for positing the slice.

  16. Lebetus scorpioides and Buenia jeffreysii (Teleostei: Gobiidae found north of the Arctic Circle

    Directory of Open Access Journals (Sweden)

    Ingvar Byrkjedal

    2016-05-01

    Full Text Available Two gobiid species, Lebetus scorpioides and Buenia jeffreysii, were recorded in northern Norway, for the first time north of the Arctic Circle. While both species were found on the continental shelf west of the Lofoten islands, one of them, L. scorpioides, was found north of 70°N off western Finnmark. The records represent a considerable northward extension of the distribution of these species. Being well within the size of reproductive individuals, the specimens appear to belong to resident populations most probably missed by earlier samplings.

  17. Characterization of cultural remains associated to a human skeleton found at the site HMS Swift (1770)

    Science.gov (United States)

    Maier, M. S.; Gómez, B. A.; Parera, S. D.; Elkin, D.; De Rosa, H.; Ciarlo, N. C.; Svoboda, H.

    2010-08-01

    Different types of materials found in association with a human skeleton found in an 18th century shipwreck in Patagonia (Argentina) were analyzed by means of OM, SEM-EDX, HPLC, and chemical analysis. Alizarin and purpurin, the main anthraquinones of the dye plant Rubia tinctorum L. (madder) were identified as the coloring matter of a red fabric attached to the skeleton. Metallographic and chemical analysis of one of the dome-shaped buttons associated to the human bones revealed that it was composed of a Pb-Sn-Cu alloy known as pewter. The results obtained support the hypothesis that the remains originally were part of a private marine uniform.

  18. MSR Founding Narratives and Content Analysis of Best/Dexter Award Nominee Papers (2001-2015)

    DEFF Research Database (Denmark)

    Tackney, Charles T.; Chappell, Stacie; Sato, Toyoko

    This is a narrative study of the founding and a research content analysis of the first 15 years of the Management Spirituality and Religion Interest Group (MSR) of the Academy of Management. Our inquiry assessed the ways in which the early collaborators established the Interest Group from archival...... data and founder interviews. The individuals interviewed were identified through preliminary inquiry and from archival data. As a complement of and extension to this inclusive founding narrative, we conducted a content and discourse analysis of the 15 years of MSR Best Papers and Carolyn Dexter Best...

  19. A history of the founding and early development of the Journal of School Psychology.

    Science.gov (United States)

    Fagan, Thomas K; Jack, Sabrina L

    2012-12-01

    Historical aspects of the founding and early development of the Journal of School Psychology are discussed. Emphases are placed on the first decade of the journal, the factors in its founding and development, persons who have served as editors and members of the editorial boards and corporate leadership, and the journal's changing formats. The publication's relationships to the Journal of School Psychology, Inc. and later to the Society for the Study of School Psychology are briefly mentioned. Copyright © 2012 Society for the Study of School Psychology. Published by Elsevier Ltd. All rights reserved.

  20. Short-period planetary-scale waves found in a Venus GCM

    Science.gov (United States)

    Takagi, M.; Sugimoto, N.; Ando, H.; Matsuda, Y.

    2017-09-01

    Short-period waves consistent with previous observations are found by using a Venus GCM. Preliminary results show that two kinds of waves with periods of about 5.5 and 7.5 Earth days are found at the cloud levels. At 68 km, vortical motions and disturbances with remarkable zonal winds are predominant at mid-latitudes and low-latitudes, respectively. The structure of the low-latitude disturbances are similar to that of the equatorial Kelvin wave. It seems that these two waves are synchronized with each other forming a planetary-scale structure symmetric about the equator.

  1. Rezension zu: Mona Motakef: Prekarisierung. Bielefeld: transcript Verlag 2015.

    Directory of Open Access Journals (Sweden)

    Martin Spetsmann-Kunkel

    2016-10-01

    Full Text Available Mona Motakef gibt in ihrem Buch einen guten Einblick in die aktuelle soziologische Prekarisierungsdebatte. Prekarisierung meint jene Prozesse sozialen Wandels, die mit einer Erschütterung bisher gültiger gesellschaftlicher Institutionalisierung und Normalität verbunden sind und zu sozialer Verunsicherung führen. Motakef geht von einem weit gefassten Prekarisierungsverständnis aus, wobei sie den Blick über die traditionelle industrie- und arbeitssoziologische Perspektive auf Aspekte aus der Genderforschung erweitert. Die Autorin referiert, dass die Prekarisierung der Existenz Ausgangspunkt für vielfältige politische Aktionen wie den Postoperaismus sein kann. Welchen Gewinn diese Erweiterung der Prekarisierungsdiagnose bringt, wird in der Rezension kritisch erörtert.

  2. Barbara Rosenkranz: MenschInnen. Graz: Ares Verlag 2008

    Directory of Open Access Journals (Sweden)

    Regina Frey

    2009-03-01

    Full Text Available Die Neue Rechte hat die Strategie Gender Mainstreaming und alle ihre Protagonist/-innen als neues Feindbild entdeckt. Die in Österreich bekannte FPÖ-Politikerin Rosenkranz polemisiert gut informiert über die „Gender-Ideologie“ und malt das Bedrohungsszenario einer geschlechtslosen und kinderlosen Gesellschaft. Für Kenner/-innen des Gender-Diskurses wird schnell deutlich, dass es hier weniger um den Gegenstand an sich als um rückwärtsgewandte Geschlechterpolitik in neuem Gewand und Wahlkampftaktik geht. Der eigentliche Zweck der Strategie Gender Mainstreaming, die Erfüllung des gesetzlichen Gleichstellungsauftrags, wird als „Tarnung“ für das Ziel der Abschaffung der Familie bezeichnet, die sexuelle Orientierung bestimmter (teilweise vermeintlicher Protagonist/-innen von Gender Mainstreaming als Indiz für das Ziel der Geschlechtslosigkeit herangezogen. Dies als rechte Verschwörungstheorie abzutun ist allerdings zu einfach: Die Autorin beruft sich ausgiebig und dezidiert auf Positionen gegen GM, die bereits in der bürgerlichen Medienlandschaft – allen voran F.A.Z. und SPIEGEL – bezogen wurden.The New Right has recently discovered the strategy of Gender Mainstreaming and all of its protagonists as new enemy terrain. The well-informed FPÖ (Austrian Freedom Party politician Rosenkranz, well known in Austria, polemicizes against “gender ideology” and paints a threatening scenario of an asexual and childless society. For those familiar with gender discourse it becomes quickly clear that these statements are not concerned with the object of criticism per se but instead the wish to perpetuate reactionary gender politics clothed in a new image for the purpose of election politics. The true purpose of the strategy of gender mainstreaming, the fulfillment of the legal task of gender equality, is described as “camouflage” for the goal of abolishing the family. The sexual orientation of specific (often alleged protagonists of gender mainstreaming is also used as an indication for the goal of promoting asexuality. It is, however, too simple to disregard this as conspiracy theory: The author extensively and decidedly relies on positions against GM that have already been referred to in the bourgeois media landscape – the FAZ and SPIEGEL at the forefront.

  3. Sandra Witte: Zouber. Hamburg: Verlag Dr. Kovač 2007

    Directory of Open Access Journals (Sweden)

    Andrea Sieber

    2009-03-01

    Full Text Available Die Freiburger Dissertation widmet sich dem Faszinosum Magie am Beispiel der höfischen Literatur des 12. und 13. Jahrhunderts. Im Zentrum steht die deskriptive Analyse von Magiedarstellungen auf der Handlungsebene fiktionaler Texte, wobei ein besonderes Augenmerk auf Geschlechterdifferenzen magiekundiger Figuren liegt. Vorab werden mögliche Schnittflächen zu zeitgenössischen Diskursen in den Bereichen Religion, Wissenschaft und Heilkunde konturiert und diese um Skizzen zu ausgewählten nichtfiktionalen Quellen ergänzt. Leider verschenkt die mediävistische Studie durch ihren überwiegend nacherzählenden Duktus das in der Magie-Thematik inhärente gender-theoretische und kulturwissenschaftliche Potential.This Freiburger dissertation approaches fascination with magic using the example of the courtly literature of the 12th and 13th centuries. Central to the study is the descriptive analysis of representations of magic at the plot level of fictional texts, whereby specific attention is paid to gender differences of those figures skilled in magic. Possible intersections with contemporary discourses in the areas of religion, science, and medical science are outlined at the outset. These are expanded with sketches of select non-fictional sources. Unfortunately, because of its tendency to uncritically re-narrate the texts, the medieval study passes up on the gender-theoretical and cultural studies oriented potential inherent to the theme of magic.

  4. 19 CFR 123.81 - Merchandise found in building on the boundary.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Merchandise found in building on the boundary. 123.81 Section 123.81 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY CUSTOMS RELATIONS WITH CANADA AND MEXICO Miscellaneous Provisions § 123.81...

  5. Bacterial communities found in placental tissues are associated with severe chorioamnionitis and adverse birth outcomes.

    Directory of Open Access Journals (Sweden)

    Ronan M Doyle

    Full Text Available Preterm birth is a major cause of neonatal mortality and morbidity worldwide. Bacterial infection and the subsequent inflammatory response are recognised as an important cause of preterm birth. It is hypothesised that these organisms ascend the cervical canal, colonise placental tissues, cause chorioamnionitis and in severe cases infect amniotic fluid and the foetus. However, the presence of bacteria within the intrauterine cavity does not always precede chorioamnionitis or preterm birth. Whereas previous studies observing the types of bacteria present have been limited in size and the specificity of a few predetermined organisms, in this study we characterised bacteria found in placental tissues from a cohort of 1391 women in rural Malawi using 16S ribosomal RNA gene sequencing. We found that specific bacteria found concurrently on placental tissues associate with chorioamnionitis and delivery of a smaller newborn. Severe chorioamnionitis was associated with a distinct difference in community members, a higher bacterial load and lower species richness. Furthermore, Sneathia sanguinengens and Peptostreptococcus anaerobius found in both matched participant vaginal and placental samples were associated with a lower newborn length-for-age Z-score. This is the largest study to date to examine the placental microbiome and its impact of birth outcomes. Our results provide data on the role of the vaginal microbiome as a source of placental infection as well as the possibility of therapeutic interventions against targeted organisms during pregnancy.

  6. Teacher to Teacher: What Text Have You Found Most Successful with Your Students?

    Science.gov (United States)

    Rallo, Curt; Roessing, Lesley J.

    2006-01-01

    "Teacher to Teacher" provides a forum for teachers to share ideas, materials, and activities. In this article, the first teacher describes the effects the well-known novel "Bleachers" (John Grisham, New York: Doubleday, 2003) had on a ninth-grade english class. The novel bought to life the high school culture that the students found challenging.…

  7. Assessing the Allergenic Potential of Molds Found in Water-Damaged Homes in a Mouse Model

    Science.gov (United States)

    Damp/moldy indoor environments, which have resulted from flooding events and may increase as a result of climate change, have been associated with asthma exacerbation. Certain molds found in significantly higher or lower concentrations in asthmatics’ homes compared to control ho...

  8. The Allergenic Potential of Molds Found in Water-Damaged Homes*

    Science.gov (United States)

    Damp/moldy environments have been associated with asthma exacerbation, but mold's role in allergic asthma induction is less clear. Recently, certain molds categorized as Group 1 were associated with asthmatics' water-damaged homes in Cleveland, while others were found more univer...

  9. Incidentally found rectal duplication during surgery for rectovestibular fistula and its management

    Directory of Open Access Journals (Sweden)

    Dhiraj K Balaji

    2015-01-01

    Full Text Available Association of rectal duplication with rectovestibular fistula is rare. A 3-month-old patient underwent primary posterior sagittal anorectoplasty (PSARP for rectovestibular fistula. During surgery the patient was found to have a rectal duplication (RD. We managed the case by excising the common wall and fenestrating the two lumens together and completed the PSARP.

  10. Incidentally found rectal duplication during surgery for rectovestibular fistula and its management.

    Science.gov (United States)

    Balaji, Dhiraj K; Basavaraju, Mamatha

    2015-01-01

    Association of rectal duplication with rectovestibular fistula is rare. A 3-month-old patient underwent primary posterior sagittal anorectoplasty (PSARP) for rectovestibular fistula. During surgery the patient was found to have a rectal duplication (RD). We managed the case by excising the common wall and fenestrating the two lumens together and completed the PSARP.

  11. Incidentally found rectal duplication during surgery for rectovestibular fistula and its management

    OpenAIRE

    Dhiraj K Balaji; Mamatha Basavaraju

    2015-01-01

    Association of rectal duplication with rectovestibular fistula is rare. A 3-month-old patient underwent primary posterior sagittal anorectoplasty (PSARP) for rectovestibular fistula. During surgery the patient was found to have a rectal duplication (RD). We managed the case by excising the common wall and fenestrating the two lumens together and completed the PSARP.

  12. Indefinite Foundings and Awkward Transitions: The Grange's Troubled Formation into an Educational Institution

    Science.gov (United States)

    Lauzon, Glenn P.

    2012-01-01

    In the closing weeks of 1867, an educational organization was founded in Washington, D.C., that should have been stillborn. Most farmers dismissed scientific agriculture as useless book-farming. They should have been lukewarm to the Patrons of Husbandry's promise to sponsor monthly meetings for mutual instruction in the application of scientific…

  13. Suillus quiescens, a new species commonly found in the spore bank in California and Oregon

    Science.gov (United States)

    Thomas D. Bruns; Lisa C. Grubisha; James M. Trappe; Jennifer F. Kerekes; Else C. Vellinga

    2010-01-01

    Suillus quiescens sp. nov. is common under Pinus muricata on Santa Cruz and Santa Rosa Islands in the northern Channel Islands of California, and we subsequently found it fruiting at Point Reyes National Seashore on the central coast of California. Sequences from the internal transcribed spacer region show that it is distinct...

  14. Ill-founded models of consumer choice in communication about food biotechnology

    DEFF Research Database (Denmark)

    Scholderer, Joachim; Bredahl, Lone; Frewer, Lynn

    2000-01-01

    Results from the CADE-GENTECH project are used to demonstrate that current practices of communication about food biotechnology are ill founded. In Study 1, leading European biotechnology experts were questioned about the communication strategies planned by their organizations. The respective...

  15. Note on the rare terrestrial orchid Apostasia elliptica found in Borneo

    NARCIS (Netherlands)

    Poulsen, A.D.

    1993-01-01

    Apostasia elliptica J.J. Smith has only been collected twice before, in Sumatra and on the Malay Peninsula. The species has now been found in Borneo. The collection by Bünnemeijer (107) from Sumatra, Westcoast Reserve, Ophir District, N of Talu represents the type and is deposited in BO. The Malay

  16. [A fish prey found in the coral snake Micrurus alleni (Serpentes: Elapidae) in Costa Rica].

    Science.gov (United States)

    Solórzano, Alejandro

    2005-01-01

    A fish prey found in the coral snake Micrurus alleni (Serpentes: Elapidae) in Costa Rica. The presence of a small specimen of the swamp eel Synbranchus marmoratus (84 mm total length) in the stomach contents of an adult coral snake Micrurus alleni with 692 mm total length from the Caribbean versant of Costa Rica is reported. This eel was swallowed headfirst.

  17. Lost in Form, Found in Line: An Exhibition of Works by Robert Motherwell

    Science.gov (United States)

    Johnson, Mark M.

    2009-01-01

    In this article, the author profiles Robert Motherwell (1915-1991) who is universally regarded as one of the most important painters and printmakers of the mid-20th century, and was a prominent figure in the movement known as Abstract Expressionism. The author also discusses the exhibition, "Lost in Form, Found in Line: An Exhibition of Works by…

  18. LANGUAGE FORM AND FUNCTION OF CARETAKERS FOUND IN NANNY MCPHEE AND THE BIG BANG MOVIE

    Directory of Open Access Journals (Sweden)

    Aditya Putri Kusuma Andani

    2016-02-01

    Full Text Available This study deals with the form and the function of caretaker speech which is found in caretaker’s utterance in Nanny McPhee and The Big Bang Movie. The objectives of this study are (1 to describe the type of language form of the caretaker and (2 to describe the type of language function of the caretaker found in Nanny McPhee and The Big Bang Movie. The type of this research is descriptive qualitative research. The data of this research are the utterance from the caretaker found in manuscript of Nanny McPhee and The Big Bang Movie. The data collection technique is documentation. The technique of analyzing data are descriptive qualitative. The writer uses the theories from Frank (1972 to analyze the type of language form, and M.A.K. Halliday (1977 to analyze the type of language function. The result of this study shows that (1 there are four types of word: noun, verb, adjective, and adverb; three types of phrase: noun phrase, verb phrase, and adverb phrase; and two types of sentence categorized into two. The first category is based on type, namely: declarative, imperative, interrogative, and exclamatory sentence; the second one by number of full predication, namely: simple, compound, complex, and compound-complex sentence. (2 The writer found 6 types of language function, they are: regulatory function, instrumental function, representational function, personal function, interactional function, and imaginative function.

  19. Pigs as natural hosts of Dientamoeba fragilis genotypes found in humans.

    Science.gov (United States)

    Cacciò, Simone M; Sannella, Anna Rosa; Manuali, Elisabetta; Tosini, Fabio; Sensi, Marco; Crotti, Daniele; Pozio, Edoardo

    2012-05-01

    Dientamoeba fragilis is a common intestinal parasite in humans. Transmission routes and natural host range are unknown. To determine whether pigs are hosts, we analyzed 152 fecal samples by microscopy and molecular methods. We confirmed that pigs are a natural host and harbor genotypes found in humans, suggesting zoonotic potential.

  20. The first carbon-enhanced metal-poor star found in the Sculptor dwarf spheroidal

    NARCIS (Netherlands)

    Skúladóttir, Á.; Tolstoy, E.; Salvadori, S.; Hill, V.; Pettini, M.; Shetrone, M. D.; Starkenburg, E.

    The origin of carbon-enhanced metal-poor (CEMP) stars and their possible connection with the chemical elements produced by the first stellar generation is still highly debated. In contrast to the Galactic halo, not many CEMP stars have been found in the dwarf spheroidal galaxies around the Milky

  1. Founders, Finding, Being Found: Women's Wisdom in Teaching and Learning in Theology and Religion

    Science.gov (United States)

    Hess, Lisa M.; Brosmer, Mary Pierce; Moore, Mary Elizabeth Mullino

    2015-01-01

    This is an edited transcript of a conversation between two founding women on the delights and demands of teaching and learning within and beyond traditional institutional life, facilitated by Lisa M. Hess of the journal's Editorial Board. The conscious feminine practices of a women's writing school, Women Writing for (a) Change (Cincinnati, Ohio),…

  2. TBK1 duplication is found in normal tension and not in high tension ...

    Indian Academy of Sciences (India)

    Supplementary data: TBK1 duplication is found in normal tension and not in high tension glaucoma patients of Indian origin. Lalit Kaurani, Mansi Vishal, Jharna Ray, Abhijit Sen, Kunal Ray and Arijit Mukhopadhyay. J. Genet. 95, 459–461. Table 1. Intraocular pressure of NTG and HTG patients. Total. Mean IOP. Mean IOP ...

  3. Wood anatomy and properties of three species in the genus Spondias lakonensis (Anacardiaceae found in Thailand

    Directory of Open Access Journals (Sweden)

    Renupha Phongkrathung

    2016-01-01

    Full Text Available The anatomy and properties of woods in the genus Spondias (Anacardiaceae were investigated. Wood samples were collected from North and Northeast Thailand. Permanent slides of wood sections and tissue maceration were made. The specimens were observed under a light microscope and using scanning electron microscopy. The wood density, specific gravity and hardness were also investigated. It was found that the wood of all three species had indistinct growth rings and fine textured and straight grain. Kribs heterogeneous rays type I were found in Spondias lakonensis while Kribs heterogeneous rays type III were found in Spondias pinnata and Spondias cytherea. Radial canals were present in rays of all studied species. Prismatic crystals were found in the rays of S. lakonensis and S. cytherea but not in S. pinnata. Starch grains were also observed in S. pinnata and S. cytherea. The wood specific gravity of S. pinnata, S. lakonensis and S. cytherea was 0.45, 0.33 and 0.30; the wood density was 0.44, 0.33 and 0.27 g/cm3 and the wood hardness was 2795.85, 1329.26 and 1059 N, respectively. The results from this study suggest that Spondias woods can be used for agricultural utensils but they are not suitable for heavy construction.

  4. Frequency of ill-founded off-label prescribing in Dutch general practice.

    NARCIS (Netherlands)

    Gijsen, R.; Jochemsen, H.; Dijk, L. van; Caspers, P.

    2009-01-01

    Purpose: The aim of this study is to quantify the extent of ill-founded off-label drug prescriptions in Dutch general practice. The study is based upon information on both the prescription itself and the patient’s medical history. Methods: In total, 48 combinations of drugs and off-label indications

  5. Distribution and Characterization of Antigens Found in Subcellular Fractions of African Trypanosomes.

    Science.gov (United States)

    1979-08-01

    Islation of bodies % containing the cyanide insensitive glycerophosphate oxidase of Trypanosoma - equiperdum . Comp. Biochem. Physiol. 30 1049-1054. S...commenced on a project aimed at characterizing the subcellular distribution and nature of antigens found in the African trypanosome, Trypanosoma rhodesiense...current project concerning the subcellular distribution and characterization of antigens in the African trypanosome, Trypanosoma rhodesiense. During

  6. Brain organization mirrors caste differences, colony founding and nest architecture in paper wasps (Hymenoptera: Vespidae).

    Science.gov (United States)

    Molina, Y; Harris, R M; O'Donnell, S

    2009-09-22

    The cognitive challenges that social animals face depend on species differences in social organization and may affect mosaic brain evolution. We asked whether the relative size of functionally distinct brain regions corresponds to species differences in social behaviour among paper wasps (Hymenoptera: Vespidae). We measured the volumes of targeted brain regions in eight species of paper wasps. We found species variation in functionally distinct brain regions, which was especially strong in queens. Queens from species with open-comb nests had larger central processing regions dedicated to vision (mushroom body (MB) calyx collars) than those with enclosed nests. Queens from advanced eusocial species (swarm founders), who rely on pheromones in several contexts, had larger antennal lobes than primitively eusocial independent founders. Queens from species with morphologically distinct castes had augmented central processing regions dedicated to antennal input (MB lips) relative to caste monomorphic species. Intraspecific caste differences also varied with mode of colony founding. Independent-founding queens had larger MB collars than their workers. Conversely, workers in swarm-founding species with decentralized colony regulation had larger MB calyx collars and optic lobes than their queens. Our results suggest that brain organization is affected by evolutionary transitions in social interactions and is related to the environmental stimuli group members face.

  7. Google vs. the Library (Part III): Assessing the Quality of Sources Found by Undergraduates

    Science.gov (United States)

    Georgas, Helen

    2015-01-01

    This study assesses and compares the quality of sources found by undergraduate students when doing research using both Google and a library (federated) search tool. Thirty undergraduates were asked to find four sources (one book, two articles, and one additional source of their choosing) related to a selected research topic. Students used both…

  8. MICROORGANISMS FOUND IN SECONDARY CATARACT MATERIAL OF ECCE PATIENTS, A STUDY WITH SEM AND TEM

    NARCIS (Netherlands)

    KALICHARAN, D; JONGEBLOED, WL; LOS, LI; WORST, JGF

    1993-01-01

    Globular secondary cataract material, removed from 24 patients with ECCE after ophthalmic cleaning of the anterior capsule, were investigated with SEM and TEM. Besides spherical, somewhat oval shaped bodies of various shape and size comparable with those found in cataractous lenses, (an)aerobic

  9. The food of some neritid prosobranch molluscs found at Mkomani Mombasa, Kenya

    OpenAIRE

    D'Souza, M.

    1986-01-01

    The findings are presented of a study conducted at Mkomani, Mombasa, investigating the Nerita species and their feeding habits. Algal food items found in the molluskan stomachs are listed. Nerita is believed to be a herbivorous gastropod feeding upon the algae off rocky shores.

  10. Path Not Found: Disparities in Access to Computer Science Courses in California High Schools

    Science.gov (United States)

    Martin, Alexis; McAlear, Frieda; Scott, Allison

    2015-01-01

    "Path Not Found: Disparities in Access to Computer Science Courses in California High Schools" exposes one of the foundational causes of underrepresentation in computing: disparities in access to computer science courses in California's public high schools. This report provides new, detailed data on these disparities by student body…

  11. GJB2 and GJB6 gene mutations found in Indian probands with ...

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Genetics; Volume 88; Issue 3. GJB2 and GJB6 gene mutations found in Indian probands ... Genetically caused deafness is a common trait affecting one in 1000 children and is predominantly inherited in an autosomal-recessive fashion. Several mutations in the GJB2 gene and a deletion of 342 ...

  12. Male Chauvinism in Colonial America: Attitudes of Some of our Founding Fathers.

    Science.gov (United States)

    Harbison, John L.

    1979-01-01

    Takes exception to the general historical presentation of the founding fathers as individuals possessing a collective eighteenth century liberalism regarding women's rights. Presents case studies of Benjamin Franklin, Thomas Jefferson, and John Adams as persons who practiced male chauvinism. Also presents a case study of Thomas Paine, who favored…

  13. A geometrical take on invariants of low-dimensional manifolds found by integration

    NARCIS (Netherlands)

    Wintraecken, M.H.M.J.; Vegter, G.

    2013-01-01

    An elementary geometrical proof of the fact that the Euler characteristic is the only topological invariant of a surface that can be found by integration (using Gauss-Bonnet) is given. A similar method is also applied to three-dimensional manifolds. (C) 2013 Elsevier B.V. All rights reserved.

  14. Invasive plants found in Alabama forests, 2009 forest inventory and analysis factsheet

    Science.gov (United States)

    Christopher M. Oswalt; Sonja N. Oswalt

    2012-01-01

    This publication provides an overview of nonnative invasive plants found in forests of the State of Alabama based on an annual inventory conducted by the Forest Inventory and Analysis (FIA) Program at the Southern Research Station of the U.S. Department of Agriculture Forest Service in cooperation with the Alabama Forestry Commission. These estimates and coverage maps...

  15. Invasive plants found in South Carolina forests, 2010 forest inventory and analysis factsheet

    Science.gov (United States)

    Christopher M. Oswalt; Sonja N. Oswalt

    2012-01-01

    This publication provides an overview of nonnative invasive plants found in forests of the State of South Carolina based on an annual inventory conducted by the Forest Inventory and Analysis (FIA) Program at the Southern Research Station (SRS) of the U.S. Department of Agriculture Forest Service in cooperation with the South Carolina Forestry Commission. These...

  16. Invasive plants found in Kentucky forests, 2009 forest inventory and analysis factsheet

    Science.gov (United States)

    Christopher M. Oswalt; Sonja N. Oswalt

    2012-01-01

    This publication provides an overview of nonnative invasive plants found in forests of the Commonwealth of Kentucky based on an annual inventory conducted by the Forest Inventory and Analysis (FIA) Program at the Southern Research Station of the U.S. Department of Agriculture Forest Service in cooperation with the Kentucky Division of Forestry. These estimates and...

  17. Invasive plants found in Virginia forests, 2010 - forest inventory and analysis factsheet

    Science.gov (United States)

    Christopher M. Oswalt; Sonja N. Oswalt

    2013-01-01

    This publication provides an overview of invasive plants found in forests of the State of Virginia based on an annual inventory conducted by the Forest Inventory and Analysis (FIA) Program at the Southern Research Station (SRS) of the Forest Service, U.S. Department of Agriculture in cooperation with the Virginia Department of Forestry. These estimates and coverage...

  18. Invasive plants found in Tennessee forests, 2009 forest inventory and analysis factsheet

    Science.gov (United States)

    Sonja N. Oswalt; Christopher M. Oswalt

    2011-01-01

    This science update provides an overview of nonnative invasive plants found in forests of the State of Tennessee based on an annual inventory conducted by the Forest Inventory and Analysis (FIA) Program at the Southern Research Station of the U.S. Department of Agriculture Forest Service in cooperation with the Tennessee Department of Agriculture Division of Forestry....

  19. Invasive plants found in Oklahoma’s forests, 2010 - forest inventory and analysis factsheet

    Science.gov (United States)

    Sonja N. Oswalt; Christopher M. Oswalt

    2014-01-01

    This science update provides an overview of nonnative invasive plants found in Oklahoma forests based on an annual inventory conducted by the Forest Inventory and Analysis (FIA) Program at the Southern Research Station (SRS) of the U.S. Department of Agriculture Forest Service in cooperation with the Oklahoma Forestry Services. These estimates and coverage maps will be...

  20. Invasive plants found in east Texas forests, 2009 forest inventory and analysis factsheet

    Science.gov (United States)

    Sonja N. Oswalt; Christopher M. Oswalt

    2011-01-01

    This science update provides information on the presence and cover of nonnative invasive plants found in forests of the eastern region of the State of Texas based on an annual inventory conducted by the Forest Inventory and Analysis (FIA) Program at the Southern Research Station of the U.S. Department of Agriculture Forest Service in cooperation with the Texas Forest...

  1. Invasive plants found in Georgia’s forests, 2010 - forest inventory and analysis factsheet

    Science.gov (United States)

    Sonja N. Oswalt; Christopher M. Oswalt

    2014-01-01

    This science update provides an overview of invasive plants found in forests of the State of Georgia based on an annual inventory conducted by the Forest Inventory and Analysis (FIA) Program at the Southern Research Station (SRS) of the U.S. Department of Agriculture, Forest Service in cooperation with the Georgia Forestry Commission. These estimates and coverage maps...

  2. Oscar Riddle's Science, a Special Bird, & the Founding of the NABT

    Science.gov (United States)

    Vandervoort, Frances S.

    2013-01-01

    Oscar Riddle, born in Indiana in 1877, was an ardent evolutionist and a key player in the founding of the National Association of Biology Teachers in 1938. He studied heredity and behavior in domestic pigeons and doves with Charles O. Whitman of the University of Chicago, received his Ph.D. in zoology in 1907, and in 1912 began a long career at…

  3. Number of queens in founding associations of the ponerine ant Pachycondyla villosa

    DEFF Research Database (Denmark)

    D'Ettorre, Patrizia; Kellner, K.; Delabie, J. H. C.

    2005-01-01

    In the ant Pachycondyla villosa, new colonies are usually started cooperatively by two or more young queens who establish a dominance order with a division of labour. Co-founding can lead to primary polygyny, where queens stay together after workers have emerged. Here we show that two queens...

  4. Griekenland aan de vooravond van de dictatuur van Metaxás : een psychoanalytische benadering van drie visies op de Griekse maatschappij

    NARCIS (Netherlands)

    Bel, G.G.

    2002-01-01

    Summary For many European states the Interwar years were a period of social-economic crises and political instability. This also holds true for Greece, especially after the events of 1923, when the Greek government had to accommodate one-and-a-half million Greek refugees form Turkey, and as a result

  5. Characteristics of female homicide offenders found not guilty by reason of insanity.

    Science.gov (United States)

    Ferranti, Jessica; McDermott, Barbara E; Scott, Charles L

    2013-01-01

    Until recently, there has been little information regarding female offenders who commit homicides that are motivated by psychosis. We investigated gender differences in the characteristics of psychosis and crime variables in psychotically motivated homicide. In the study, conducted at a large U.S. forensic facility, we reviewed the records of women (n = 47) found not guilty by reason of insanity (NGRI) who were hospitalized between January 1991 and August 2005 for a homicide offense. A random sample of 47 men who were committed during the same period for the same offenses was selected for comparison. Religious delusions were found more often in women who killed infants (0-1 year of age) and children between the ages of 2 and 18. Women were more likely to have a diagnosis of an affective problem and borderline personality disorder. The results indicate gender-specific areas to focus on during clinical and forensic assessments of the risk of violence in women with psychosis.

  6. Ants as shell collectors: notes on land snail shells found around ant nests

    Directory of Open Access Journals (Sweden)

    Barna Páll-Gergely

    2009-03-01

    Full Text Available We investigated the shell collecting activities of harvester ants (Messor spp. in semi-arid grasslands and shrubs in Turkey. We found eleven species of snails in the area, two of them were not collected by ants. Eight – mainly small sized – snail species were found on ant nests in a habitat characterized by shrubs, three in rocky grassland and four in a grassland habitat. Some shells (e.g. Chondrus zebrula tantalus, Multidentula ovularis might be taken into the nests, and we hypothesise that some of these snail species are consumed by ants (Monacha spp.. From a fauna inventory perspective, shell collecting activities of harvester ant may help malacologists to find snail species which are normally hidden for a specialist (e.g. Oxychilus hydatinus, Cecilioides spp. due to their special habits.

  7. A Homoploid Hybrid Between Wild Vigna Species Found in a Limestone Karst

    Science.gov (United States)

    Takahashi, Yu; Iseki, Kohtaro; Kitazawa, Kumiko; Muto, Chiaki; Somta, Prakit; Irie, Kenji; Naito, Ken; Tomooka, Norihiko

    2015-01-01

    Genus Vigna comprise several domesticated species including cowpea and mungbean, and diverse wild species. We found an introgressive hybrid population derived from two wild species, Vigna umbellata and Vigna exilis, in Ratchaburi district, Thailand. The hybrid was morphologically similar to V. umbellata but habituated in a limestone rock mountain, which is usually dominated by V. exilis. Analyzing simple sequence repeat loci indicated the hybrid has undergone at least one round of backcross by V. umbellata. We found the hybrid acquired vigorous growth from V. umbellata and drought tolerance plus early flowering from V. exilis, and thus has taken over some habitats of V. exilis in limestone karsts. Given the wide crossability of V. umbellata, the hybrid can be a valuable genetic resource to improve drought tolerance of some domesticated species. PMID:26648953

  8. Primary cilia found on HeLa and other cancer cells.

    Science.gov (United States)

    Kowal, Tia J; Falk, Matthias M

    2015-11-01

    For many years now, researchers have known of a sensory appendage on the surface of most differentiated cell types called primary cilium. Primary cilia are both chemo- and mechano-sensory in function and have an obvious role in cell cycle control. Because of this, it has been thought that primary cilia are not found on rapidly proliferating cells, for example, cancer cells. Here we report using immunofluorescent staining for the ciliary protein Arl13b that primary cilia are frequently found on HeLa (human epithelial adenocarcinoma) and other cancer cell lines such as MG63 (human osteosarcoma) commonly used for cell culture studies and that the ciliated population is significantly higher (ave. 28.6% and 46.5%, respectively in starved and 15.7-18.6% in un-starved cells) than previously anticipated. Our finding impacts the current perception of primary cilia formed in highly proliferative cells. © 2015 International Federation for Cell Biology.

  9. Financial Management Competence of Founding Teams and Growth of New Technology-Based Firms

    DEFF Research Database (Denmark)

    Brinckmann, Jan; Gemuenden, Hans Georg; Salomo, Søren

    2009-01-01

    firms. We explore the relevance of strategic financial planning competence, external financing competence, competence in financing from cash flow, and controlling competence of entrepreneurial teams for the growth of new technology-based firms. A total of 212 founding teams provided self......This article draws on the resource-based view to analyze the role founding teams' financial management competencies play for firm growth. Prior research stressed the importance of acquiring external financial resources. In this study, we broaden the understanding of financial management in new......-assessments of their financial management competencies at start-up. We apply the partial least squares approach to determine the effects of the different financial management competencies on firm growth....

  10. The performance evaluation model of mining project founded on the weight optimization entropy value method

    Science.gov (United States)

    Mao, Chao; Chen, Shou

    2017-01-01

    According to the traditional entropy value method still have low evaluation accuracy when evaluating the performance of mining projects, a performance evaluation model of mineral project founded on improved entropy is proposed. First establish a new weight assignment model founded on compatible matrix analysis of analytic hierarchy process (AHP) and entropy value method, when the compatibility matrix analysis to achieve consistency requirements, if it has differences between subjective weights and objective weights, moderately adjust both proportions, then on this basis, the fuzzy evaluation matrix for performance evaluation. The simulation experiments show that, compared with traditional entropy and compatible matrix analysis method, the proposed performance evaluation model of mining project based on improved entropy value method has higher accuracy assessment.

  11. Most Campylobacter subtypes from sporadic infections can be found in retail poultry products and food animals

    DEFF Research Database (Denmark)

    Nielsen, Eva M.; Fussing, V.; Engberg, J.

    2006-01-01

    The subtypes of Campylobacter isolates from human infections in two Danish counties were compared to isolates from retail food samples and faecal samples from chickens, pigs and cattle. During a 1-year period, 1285 Campylobacter isolates from these sources were typed by two methods: 'Penner' heat......-stable serotyping and automated ribotyping (RiboPrinting). C. jejuni was the dominating species, but C. coli was more prevalent among food and chicken isolates (16%) compared to human isolates (4%). In total, 356 different combined sero-ribotypes (subtypes) were found. A large subtype overlap was seen between human...... isolates and isolates from food (66%), chickens (59%) and cattle (83%). This was verified by PFGE typing of 212 isolates representing selected subtypes. All frequent (n > 3) subtypes found in food were also present in humans. Sixty-one per cent of the isolates from domestically acquired infections had...

  12. Microfungi found on phellen of Jugulans nigra L. in Southeastern Ohio, USA

    Directory of Open Access Journals (Sweden)

    Emanuel D. Rudolph

    2014-01-01

    Full Text Available Bark surfaces from black walnut (Jugulans nigra trees of three sites in southeastern Ohio, half. Five. and ten miles from the Ohio River, were used in late autumn to isolate fungi in culture. as well as to search for the presence of fungal mycelium and spores. The pH of the cork also was determined. Fifty six, mostly cosmopolitan, species of microfungi and several yeasts were isolated, almost all belonging to imperfect form genera. with the largest number of species in the genus Penicillium. No relationship of fungal presence to cork pH was found among the sites whose acidity was related to closeness to the industrialized river edge. Relatively few fungi were isolated. and even fewer spores, and only four mycelia growths were found by electron microscopy. Several spores seen could not be matched with fungi that had been isolated. The bark seems to be a trapping surface for spores. rather than a place of fungal growth.

  13. Cinderella's Lessons on Footbinding: How Tiny Feet Found their Way into the Chinese Cinderella Story

    Directory of Open Access Journals (Sweden)

    Tyler Scott Smith

    2013-05-01

    Full Text Available The story of Cinderella has had many variants, some dating back to ancient Tibetan trade routes and dynastic China. When the tale is analysed in comparison to other variants it is found that in the Chinese version Yeh-Shen (Cinderella is prized for the small size of her feet. The result of Yeh-Shen having small feet in the story is that she is led her into wealth, power and marriage, the same pursuable goals that led to the custom of footbinding. In southern China the custom of footbinding became a historically defining feature of the society. A women's beauty and her delicacy were judged by the size of her feet, and small feet were the aim of the binding. Small feet played such an important role in the society that it can be found as early as the ninth century C.E., in the traditional oral story, Yeh-Shen.

  14. A Descriptive Study of Registers Found in Spoken and Written Communication (A Semantic Analysis

    Directory of Open Access Journals (Sweden)

    Nurul Hidayah

    2016-07-01

    Full Text Available This research is descriptive study of registers found in spoken and written communication. The type of this research is Descriptive Qualitative Research. In this research, the data of the study is register in spoken and written communication that are found in a book entitled "Communicating! Theory and Practice" and from internet. The data can be in the forms of words, phrases and abbreviation. In relation with method of collection data, the writer uses the library method as her instrument. The writer relates it to the study of register in spoken and written communication. The technique of analyzing the data using descriptive method. The types of register in this term will be separated into formal register and informal register, and identify the meaning of register.

  15. Two Invasive Thymomas Incidentally Found during Coronary Artery Bypass Graft Surgery

    Directory of Open Access Journals (Sweden)

    Navid Omidifar

    2016-01-01

    Full Text Available Thymoma, the most common neoplasm of the anterior mediastinum, is a rare tumor of thymic epithelium that can be locally invasive. We reported 2 cases of invasive thymoma incidentally found during routine coronary artery bypass graft (CABG surgery at Faghihee Hospital of Shiraz University of Medical Sciences of Iran in a period of about 6 months. The 2 patients were male and above 60 years old. They had no clinical symptoms and radiological evidence of mediastinal mass before detection of the tumor during operation. For both patients mass was completely excised and sent to the laboratory. The ultimate pathological diagnosis of both masses was invasive thymoma (stage 2. There are few reports in which thymomas were found incidentally during cardiac surgery. In spite of rare coincidence, due to being asymptomatic and possibly invasive, special attention to thymus gland during cardiac surgery or other mediastinal surgery and preoperative imaging studies seem to be reasonable approach.

  16. A retrospective analysis of serum tumor markers found in non-small cell lung cancer

    Directory of Open Access Journals (Sweden)

    Qin Hu

    2016-01-01

    Conclusion: Although the positive CEA, CYFRA 21-1, NSE, and TSGF rates were observed at low values during the NSLCLC serum diagnosis, they still played an important role in diagnosing lung cancer. Significant levels of CEA, CYFRA 21-1, NSE, and TSGF were detected in the serum. The amounts found were useful for diagnosing NSCLC patients who depended on the currently limited biomarker development.

  17. Why are dense planetary rings only found between 8 and 20 AU?

    OpenAIRE

    Hedman, M. M.

    2015-01-01

    The recent discovery of dense rings around the Centaur Chariklo (and possibly Chiron) reveals that complete dense planetary rings are not only found around Saturn and Uranus, but also around small bodies orbiting in the vicinity of those giant planets. This report examines whether there could be a physical process that would make rings more likely to form or persist in this particular part of the outer Solar System. Specifically, the ring material orbiting Saturn and Uranus appears to be much...

  18. Donald T. Clark: Early UCSC History and the Founding of the University Library

    OpenAIRE

    Regional History Project, UCSC Library; Clark, Donald T.; Jarrell, Randall

    1993-01-01

    Donald T. Clark was the first of founding Chancellor Dean E. McHenry's academic appointments at UCSC. Clark arrived in September 1962 as the founder of UC Santa Cruz's University Library. Clark described his early years in Oregon and California, his undergraduate education at Willamette University, UC Berkeley, and Columbia University, and his more than twenty years at the country's largest business library, Baker Library at Harvard University. He focused much of his oral history on his tenur...

  19. Variations in spa types found in consecutive MRSA isolates from the same patients

    DEFF Research Database (Denmark)

    Boye, Kit; Westh, Henrik

    2010-01-01

    Very little is known about how the spa gene mutates over time in methicillin-resistant Staphylococcus aureus (MRSA) from the same patient. Copenhagen is an area with low prevalence of MRSA but with high variability in spa types. We collected 1536 MRSA isolates from 319 patients during a 5-year...... period and found spa type alterations in 30 MRSA isolates (2%) from 13 patients (4%). The alteration most often seen was the deletion of repeats followed by repeat duplication and point mutation....

  20. Disciplines of Collection: Founding the Dresden Museum for Zoology, Anthropology and Ethnology in Imperial Germany

    OpenAIRE

    Petrou, Marissa Helene

    2016-01-01

    I explore three different themes in the history of science through the lens of the museum: 1) science and the public; 2) science and empire; 3) material and visual culture. The book is an institutional history of a provincial museum with international aspirations to standardize museum management and anthropological practice. The founding director of the Dresden Museum for Zoology, Anthropology and Ethnography proposed an historical, non-essentialist approach to understanding racial and cultur...

  1. UV Properties of High-Z Supernovae Found In Archival CFHTLS Data

    Science.gov (United States)

    Pritchard, Tyler A.; Cooke, Jeff

    2016-01-01

    Using a novel technique to detect z≥1.7 archival supernovae in the CFHT Legacy Survey (CFHTLS) we discuss rest-frame UV comparisons between a local sample comprised of Swift (photometric) and HST (spectroscopic) data and a high redshift CFHTLS (photometric) + Keck/LRIS (spectroscopic); as well as observations on the horizon for z≥2.5 Superluminous supernovae (SLSN) found through the Search for Superluminous Supernovae using DECam (SUDSS) and it's u-band companion program necessary for this technique.

  2. Has the substructure of quarks been found by the CDF experiment?

    Energy Technology Data Exchange (ETDEWEB)

    Akama, Keiichi [Saitama Medical Coll., Moroyama (Japan); Terazawa, Hidezumi

    1996-08-01

    The significant excess recently found by the CDF Collaboration in the inclusive jet cross section for jet transverse energies E{sub T} {>=} 200 GeV over current QCD predictions can be explained either by possible production of excited bosons (excited gluons, weak bosons, Higgs scalars, etc.) or by that of excited quarks. The masses of the excited boson and the excited quark are estimated to be around 1600 GeV and 500 GeV, respectively. (author)

  3. Why cholesterol should be found predominantly in the cytoplasmic leaf of the plasma membrane

    CERN Document Server

    Giang, Ha

    2014-01-01

    In the mammalian plasma membrane, cholesterol can translocate rapidly between the exoplasmic and cytoplasmic leaves, and is found predominantly in the latter. We hypothesize that it is drawn to the inner leaf to reduce the bending free energy of the membrane caused by the presence there of phosphatidylethanolamine. Incorporating this mechanism into a model free energy for the bilayer, we calculate that approximately two thirds of the total cholesterol should be in the inner leaf.

  4. First paleoparasitological study of an embalming rejects jar found in Saqqara, Egypt

    Directory of Open Access Journals (Sweden)

    Harter Stéphanie

    2003-01-01

    Full Text Available For the first time, a jar of embalming rejects was studied in search for helminth parasite eggs. This kind of jar was used to put discarded material by Egyptian embalmers during mummification process. Ascaris lumbricoides and Tænia saginata eggs were found in the linen and strip fragment contents of the jar, dated of 2,715-2,656 years ago.

  5. Incidentally found situs inversus with dextrocardia: inferior myocardial infarction in an 86-year-old woman.

    Science.gov (United States)

    Hudzik, Bartosz; Polonski, Lech

    2012-10-01

    Situs inversus with dextrocardia is a rare condition. Yet, the incidence of atheroclerosis and myocardial infarction in patients with dextrocardia is similar to that in general population. The diagnosis of acute myocardial infarction is somewhat tricky and difficult if the dextrocardia is not recognized. We present the electrocardiogram, coronary angiograms, and chest radiogram of a patient with incidentally found situs inversus with dextrocardia. © 2012, Wiley Periodicals, Inc.

  6. Spiders (Araneae) Found in Bananas and Other International Cargo Submitted to North American Arachnologists for Identification.

    Science.gov (United States)

    Vetter, Richard S; Crawford, Rodney L; Buckle, Donald J

    2014-11-01

    Spiders found in international cargo brought into North America are sometimes submitted to arachnologists for identification. Often, these spiders are presumed to be of medical importance because of size or a submitter's familiarity with a toxic spider genus from the continent of origin. Starting in 2006, requests were made for spiders found in international cargo brought into North America, in addition to the specimens from similar cargo shipments already in our museum collections. This was an ad hoc study that allowed us to focus on spiders of concern to the discoverer. We identified 135 spiders found in international cargo. A key for the most common species is provided. The most frequently submitted spiders were the pantropical huntsman spider, Heteropoda venatoria (L.) (Sparassidae), and the redfaced banana spider, Cupiennius chiapanensis Medina Soriano (Ctenidae). Spiders of medical importance were rare. The most common cargo from which spiders were submitted was bananas with most specimens coming from Central America, Ecuador, or Colombia. Lack of experience with nonnative fauna caused several experienced American arachnologists to misidentify harmless ctenid spiders (C. chiapanensis, spotlegged banana spider, Cupiennius getazi Simon) as highly toxic Phoneutria spiders. These misidentifications could have led to costly, unwarranted prophylactic eradication measures, unnecessary employee health education, heightened employee anxiety and spoilage when perishable goods are left unloaded due to safety concerns. © 2014 Entomological Society of America.

  7. Ellagic acid and its methyl-derivatives inhibit a newly found nitratase activity.

    Science.gov (United States)

    Léger, Claude L; Torres-Rasgado, Enrique; Fouret, Gilles; Lauret, Céline; Carbonneau, Marie-Annette

    2010-02-01

    We have recently shown that low density lipoprotein (LDL) was able to denitrate albumin-bound 3-NO(2)-Tyr residues and to concomitantly release NO(3)(-) through a Ca(2+)-dependent process that has been ascribed to a specific protein structure. A lipophilic food component (gamma-tocopherol), which is easily loaded into LDL has been found to totally inhibit denitrating activity. We presently found that ellagic acid (EA) and its methylated derivatives, 4,4'O-methyl- and 3,3'O-methyl-ellagic acids (MeEA1 and MeEA2, respectively), amphipathic phenolic components of certain fruits and beverages, were also able to inhibit this activity, with a total inhibition for EA and a 60% inhibition for MeEA1 and MeEA2. EA exhibited the highest affinity for protein plasma, whereas a higher affinity of MeEA1 and MeEA2 (with MeEA1 > MeEA2) than EA was found for lipoprotein fractions, suggesting that the inhibition-driving property is protein affinity. As a result of this nitratase-inhibition property EA and its natural metabolite MeEA2 may have a beneficial role in special physiopathological conditions.

  8. Chronology, Narrative, and Founding Acts: Between a Transcendental Rock and a Decisionist Hard Place

    Directory of Open Access Journals (Sweden)

    Jack Reilly

    2015-06-01

    Full Text Available In attempting to represent political transformations, we often encounter a moment that seems to resist narrativisation, a moment of obstinate inconsistency which various theoretical, historical and fictional accounts cannot properly absorb except by way of indicating the parameters of a rupture. Here, I present a position which views these unrepresentable moments as structurally necessary features of revolutionary events. It is not simply that, at such historical junctures, we are faced with an abundance of information and that the unrepresentability or narrative deficit is the consequence of this surplus; on the contrary, the founding act that accompanies any radical transformation necessarily involves a certain temporal contraction. To the extent that narrative relies on a linear chronology, it fails to capture this moment of contraction. Indeed, this is why works of political philosophy associated with a founding contract (for example Hobbes’s Leviathan and Rousseau’s Social Contract cannot fully suppress the moment of circularity in which the rhythm of chronological time skips a beat and, to paraphrase Rousseau, one requires an effect to perform the function associated with its own cause. If the moment of founding can be represented at all, it is only by way of paradox and metaphor.

  9. A divergent Cardinium found in daddy long-legs (Arachnida: Opiliones).

    Science.gov (United States)

    Chang, Jin; Masters, Amber; Avery, Amanda; Werren, John H

    2010-11-01

    Recent studies indicate that a newly described bacterial endosymbiont, Cardinium, is widespread in arthropods and induces different reproductive manipulations in hosts. In this study, we used a portion of the 16S rRNA gene of the Cardinium to screen 16 Opilionid species from the suborder Palptores. We found the incidence of Cardinium in these Opiliones was significantly higher than in other pooled arthropods (31.2% versus 7.2%, P=0.007). Phylogenetic analyses using maximum parsimony (MP) and Bayesian analysis revealed two distinct clades in Opiliones. One is a divergent monophyletic clade with strong support that has so far not been found in other arthropods, and a second one contains Cardinium both from Opiliones and other arthropods. There is not complete concordance of the Cardinium strains with host phylogeny, suggesting some horizontal movement of the bacteria among Opiliones. Although the divergence in the sequenced 16S rRNA region between the Cardinium infecting Opiliones and Cardinium from other arthropods is greater than among Cardinium found in other arthropods, all are monophyletic with respect to the outgroup bacteria (endosymbionts of Acanthamoeba). Based on high pairwise genetic distances, deep branch, and a distinct phylogenetic grouping, we conclude that some Opiliones harbor a newly discovered Cardinium clade. Copyright © 2010 Elsevier Inc. All rights reserved.

  10. Variability of Old Sweet Cherries Found in Slovak Regions and Their Preservation

    Directory of Open Access Journals (Sweden)

    Benková Michaela

    2017-06-01

    Full Text Available The work is focused on the evaluation of variability of morphological and pomological characteristics of several old sweet cherries (Prunus avium L. that were found in different Slovak regions. The experimental work has been performed during two years, 2014 and 2015. The following characteristics according to the descriptor list of subgenus Cerasus were evaluated - period of flowering and ripening, morphological characteristics of the flowers, fruit size, fruit weight, and quality parameters. The results showed high variability of evaluated accessions. From the 13 surveyed localities, the most valuable accessions were found in the locality Hornį Streda - places Čachtice, Krakovany, Nitra, and Brdárka. During the collecting expeditions, 170 accessions of sweet cherry, with fruit of the different quality were found. The most interesting accessions were grafted onto rootstocks with different intensity of growth (Prunus avium L., Prunus mahaleb L., and ‘Gisela5’. Some of the selected cherry accessions can be used for commercial growing after tests, while some of them can be used only for collection of genetic resources and as potential genitors in breeding programmes.

  11. Metal resistance systems in cultivated bacteria: are they found in complex communities?

    Science.gov (United States)

    Gillan, David C

    2016-04-01

    Metal resistance systems found in complex bacterial communities by shotgun metagenomic approaches were reviewed. For that, 6 recent studies investigating 9 metal-contaminated environments (water or sediments) were selected. Of the 22 possible metal-resistance systems, only 14 were found in complex communities. These widespread and easily detected metal-resistance systems were mainly biogenic sulfide production (dsr genes), resistance mediated in the periplasm (CopK and multicopper oxidases such as PcoA/CopA), efflux proteins (HME-RND systems, P-type ATPases, and the cation diffusion facilitator CzcD) as well as proteins used to treat oxidative damages (e.g., SodA) and down-regulation of transporters. A total of 8 metal-resistance systems were not found in the complex communities investigated. These rare systems include metal resistance by phosphatases, ureases, metallophores, outer membrane vesicles, methylation genes and cytoplasmic metal accumulation systems. In this case rarity may also be explained by a lack of knowledge on the specific genes involved and/or analytical biases. Copyright © 2016 Elsevier Ltd. All rights reserved.

  12. Prevalence of Intestinal Parasites in School: a Review Profile Found in the Different Regions From Brazil

    Directory of Open Access Journals (Sweden)

    Valesca Francisco Pinto Menezes

    2012-12-01

    Full Text Available Intestinal infections caused by protozoa and helminths are considered a major cause of diseases by infectious processes in the world. The present study aims to conduct a survey regarding the recent years of the prevalence of intestinal parasites in school children in various cities in Brazil, identifying which species are most commonly found and the regions that require greater dedication in this area. The analyzed studies showed that the Northern and Northeastern regions presented a higher prevalence of intestinal parasites, however, in the Southeast, results were encouraging with low levels of contamination by parasites compared to all regions in Brazil. As for intestinal parasites, the most common, found in all Brazilian regions, was Ascaris lumbricoides followed by Giardia lamblia. Therefore, one can conclude that the high prevalence of intestinal parasites in children found in some places in Brazil can demonstrate the need for greater care with basic sanitation and personal hygiene, both in households and in the places of study. These data show the importance of conducting educational programs that will develop personal awareness of parents, families and children themselves.

  13. Characterization on Eye Glass Bead Found at Khao Sri Vichai (Surat Thani), Thailand

    Science.gov (United States)

    Won-in, K.; Thongkam, Y.; Dhammanonda, W.; Dutchaneephet, J.; Kamwanna, T.; Intarasiri, S.; Tancharakorn, S.; Tanthanuch, W.; Dararutana, P.

    It was known that eye glass beads originated in the Near East during the mid 2nd millennium BC and spread to Mediterranean and Asia. In Thailand, they have been found at various archaeological sites in southern areas, especially the ancient maritime ports. In this work, Scanning electron microscope coupled with energy dispersive X-ray fluorescence spectroscopy (SEM-EDS), proton induced X-ray emission spectroscopy (PIXE), micro-beam X-ray fluorescence spectroscopy based on synchrotron radiation (μ-SRXRF) and Raman spectroscopy were carried out to characterize the composition of the eye-glass bead which excavated from Khao Sri Vichai at Surat Thani Province. It has a black body, dark blue pupil and ochre circle pattern on the inlaid white eyeball. It was found that its shape was similar as those which were unearthed from the ancient tombs of the Early Warring State Period (∼500 B.C.) at China. The main compositions were alkali-silicate glass. Surface microstructure has been found to be corroded. This data was one of the evidences which confirmed the ancient long distance trade or exchange network.

  14. Striking Graphite Bearing Clasts Found in Two Ordinary Chondrite Samples; NWA6169 and NWA8330

    Science.gov (United States)

    Johnson, Jessica M.; Zolensky, Michael E.; Chan, Queenie; Kring, David A.

    2015-01-01

    Meteorites play an integral role in understanding the history of the solar system. Not only can they contain some of the oldest material found in the solar system they also can contain material that is unique. Many lithologies are only found as foreign clasts within distinctly different host meteorites. In this investigation two foreign clasts within the meteorites, NWA6169 and NWA8330 were studied. The purpose of this investigation was to examine the mineralogy and petrography of the clasts within the samples. From there an identification and possible origin were to be inferred. NWA6169 is an unclassified ordinary chondrite that has a presumed petrologic type of L3. NWA8330 is a classified ordinary chondrite that has a petrologic type of LL3. Both meteorites were found to contain clasts that were similar; both modally were comprised of about 5% acicular graphite. Through SEM and Raman Spectroscopy it was found that they contained olivine, pyroxene, plagioclase, Fe-Ni sulfides, graphite, and metals. They were found to portray an igneous texture with relationships that suggest concurrent growth. Analytical microprobe results for NWA6169 revealed mineral compositions of Fa31-34, Fs23-83, and Ab7-85. For NWA8330 these were Fa28-32, Fs10-24, and Ab4-83. Only one similar material has been reported, in the L3 chondrite Krymka (Semenenko & Girich, 1995). The clast they described exhibited similar mineralogies including the unusual graphite. Krymka data displayed compositional values of Fa28.5-35.0 and Fs9-25.9. These ranges are fairly similar to that of NWA6169 and NWA8330. These samples may all be melt clasts, probably of impact origin. Two possibilities are (1) impact of a C-type asteroid onto the L chondrite parent asteroid, and (2) a piece of proto-earth ejected from the moon-forming collision event. These possibilities present abundant questions, and can be tested. The measurement of oxygen isotope compositions from the clasts should reveal the original source of the

  15. THE 100th ANNIVERSARY OF THE FOUNDING THE SOCIETY OF SCHOOL EDUCATION

    Directory of Open Access Journals (Sweden)

    Oksana Bunchuk

    2017-04-01

    Full Text Available Researched archival materials give grounds to assume that the history of the Ukrainian school in the early twentieth century is closely connected with the history of the Society of School Education(SSE. In the period of national democratic revolution of Ukrainian people, when they first tried to found their school community organization and the Society of School Education had the honorary guiding part in this field. In fact, SSE was engaged in the Affairs of education in Ukraine before the first Ukrainian educational governing body, the General Secretariat of Education, had been formed. Society of School Education was founded on 10th April 1917 with the aim of spreading education among the Ukrainian people in primary, secondary and high schools, implementing the Ukrainian language into teaching. I. Steshenko was elected the first Chairman of the Society by Deputy Chairman P. Kholodnyi. The Society of School Education worked in accordance with the “Charter of the Ukrainian Society of School education” which was introduced by the founders of the Society and approved by the Kiev District Court on 20th October 1917. In different political periods, it was adjusted, supplemented to fulfill all the tasks on development of the Ukrainian school according to the first Charter in 1917. The analysis of the structure of the SSE Board has shown that the composition of the Board remained unchanged – the Chairman, Deputy Chairman, six members who were elected at the General Meeting by a vote majority. The first Ukrainian school was founded with the active participation of SSE, it played an important part in the Ukrainization of schools in the country, arranging the first course of Ukrainian for teachers in Ukraine in 1917, providing school education reforms and being responsible for the terminology and the publication of school textbooks. By the time the first Ministry of Education of Ukrainian was established, the Society had become the highest

  16. Micro-analytical evidence of origin and degradation of copper pigments found in Bohemian Gothic murals.

    Science.gov (United States)

    Svarcová, Silvie; Hradil, David; Hradilová, Janka; Kocí, Eva; Bezdicka, Petr

    2009-12-01

    Correct identification of pigments and all accompanying phases found in colour layers of historical paintings are relevant for searching their origin and pigment preparation pathways and for specification of their further degradation processes. We successfully applied the analytical route combining non-destructive in situ X-ray fluorescence analyses with subsequent laboratory investigation of micro-samples by optical microscopy, scanning electron microscopy/energy-dispersive spectroscopy and X-ray powder micro-diffraction (micro-XRD) to obtain efficiently all the data relevant for mineralogical interpretations of the copper pigments origin. Cu salts (carbonates, chlorides, sulphates, etc.) used as pigments exist in a range of polymorphs with similar or identical composition. The efficiency of the micro-XRD for direct identification of such crystal phases present in micro-samples of colour layers was demonstrated in the presented paper. A new, until now unpublished, type of copper pigment--cumengeite, Pb(21)Cu(20)Cl(42)(OH)(40)--used as a blue pigment on a sacral wall painting in the Czech Republic was found by means of micro-XRD. Furthermore, azurite, malachite, paratacamite, atacamite and posnjakite were identified in fragments of colour layers of selected Gothic wall paintings. We found Cu-Zn arsenates indicating the natural origin of azurite and malachite; artificial malachite was distinguishable according to its typical spherulitic crystals. The corrosion of blue azurite to green basic Cu chloride was clearly evidenced on some places exposed to the action of salts and moisture-in a good agreement with the results of laboratory experiments, which also show that oxalic acid accelerates the corrosion of Cu pigments.

  17. On freak minor octopus, Octopus minor, found out in Imabari Fish Market, Ehime Prefecture

    OpenAIRE

    Higashide, Ryosuke; Sakai, Yoichi; Hashimoto, Hiroaki

    2007-01-01

    The three male freak minor octopus, Octopus minor were found out on Fish Market of Imabari Fisheries Cooperative, Ehime Prefecture, Japan. One of them was the octopus landed on May 25, 2006, which had two hectocotilized arms on both of the third right and left, though male octopus usually has only one hectocotilized arm on the third right arm. It was seemed to be arisen from the abnormal generation. Another ones were landed on the Fish Market on April 16 and June 26, 2007, respectively. Both ...

  18. Let me sing your songs: how Finns found xöömei

    OpenAIRE

    Sauli Heikkilä

    2017-01-01

    The author of this essay, musician and founder of the Throat Singing Association of Finland (1997), tells the story of how an association of throat singing practitioners came to be in Finland, and how to teach this art to those wishing to learn it. The story also covers the author’s own musical preferences and his life-changing visit to a week-long workshop led by Boris Salchak from Tuva in 1995. Two years later, the author and other aficionados of Tuvan xöömei founded the Throat Singing Asso...

  19. A pioneer survey and DNA barcoding of some commonly found gastropod molluscs on Robben Island

    Science.gov (United States)

    van der Bank, Herman; Greenfield, Richard

    2015-01-01

    Abstract Nineteen species of abundant gastropods were collected at Robben Island, including introduced dune snails and European brown garden snails. They were identified using morphology and DNA barcoding. It was expected that the species recorded would be similar to those from the Cape peninsula, South Africa, but we were surprised to find some exceptions: the very abundant invasive mussel species in South Africa, the South American bisexual mussel (Semimytilus algosus), and the beaded topshells (Oxystele impervia) were not found on Robben Island. Possible explanations are presented for these differences. PMID:25685029

  20. A pioneer survey and DNA barcoding of some commonly found gastropod molluscs on Robben Island.

    Science.gov (United States)

    van der Bank, Herman; Greenfield, Richard

    2015-01-01

    Nineteen species of abundant gastropods were collected at Robben Island, including introduced dune snails and European brown garden snails. They were identified using morphology and DNA barcoding. It was expected that the species recorded would be similar to those from the Cape peninsula, South Africa, but we were surprised to find some exceptions: the very abundant invasive mussel species in South Africa, the South American bisexual mussel (Semimytilusalgosus), and the beaded topshells (Oxysteleimpervia) were not found on Robben Island. Possible explanations are presented for these differences.

  1. A pioneer survey and DNA barcoding of some commonly found gastropod molluscs on Robben Island

    Directory of Open Access Journals (Sweden)

    Herman Van Der Bank

    2015-02-01

    Full Text Available Nineteen species of abundant gastropods were collected at Robben Island, including introduced dune snails and European brown garden snails. They were identified using morphology and DNA barcoding. It was expected that the species recorded would be similar to those from the Cape peninsula, South Africa, but we were surprised to find some exceptions: the very abundant invasive mussel species in South Africa, the South American bisexual mussel (Semimytilus algosus, and the beaded topshells (Oxystele impervia were not found on Robben Island. Possible explanations are presented for these differences.

  2. Chemical Analysis of Organic Residues Found in Hellenistic Time Amphorae from SE Bulgaria

    Science.gov (United States)

    Zlateva, B.; Rangelov, M.

    2015-05-01

    We have used IR spectroscopy, 1H NMR spectroscopy, high-performance liquid chromatography and thin-layer chromatography to study the composition of resin residues found in 22 amphorae from Apollonia Pontika (SE Bulgaria). In particular this analysis of the resin residues was aimed at discovering the content of the amphorae and to verify the hypothesis on the transport of wine, named "Retsina". Additionally this hypothesis has been confirmed by a similar analysis of the modern resin sample from Aleppo pine (Pinus Halepensis) growing in the Attica region (Greece).

  3. Complex Formation of Selected Radionuclides with Ligands Commonly Found in Ground Water: Low Molecular Organic Acids

    DEFF Research Database (Denmark)

    Jensen, Bror Skytte; Jensen, H.

    1985-01-01

    A general approach to the analysis of potentiometric data on complex formation between cations and polybasic amphoteric acids is described. The method is used for the characterisation of complex formation between Cs+, Sr2+, Co2+, La 3+, and Eu3+ with a α-hydroxy acids, tartaric acid and citric ac......, and with the α-amino acids, aspartic acid and L-cysteine. The cations have been chosen as typical components of reactor waste, and the acids because they are often found as products of microbial activity in pits or wherever organic material decays...

  4. The role of the founding entrepreneur in the transformation from micro enterprises to small firms

    DEFF Research Database (Denmark)

    Pötz, Katharina Anna

    the role of the founding entrepreneurs in the transformation from micro enterprises to small firms. The transformation is conceptualized as a first step towards future growth and empirically investigated by analyzing qualitative data from case studies of agribusiness and food entrepreneurs in Tanzania...... that provide even successful microentrepreneurs with little guidance on how to manage and organize a small firm. Data analysis focus of their behaviors, emotions, and cognitions in response to experiencing internal and external growth challenges. The findings indicate that what entrepreneurs think, feel...

  5. Halicephalobus laticauda sp. n. , a nematode found in a Belgian coal mine (Nematoda, Rhabditida)

    Energy Technology Data Exchange (ETDEWEB)

    Geraert, E.; Sudhaus, W.; Lenaerts, L.; Bosmans, E.

    1988-06-01

    In a search for Strongyloides stercoralis juveniles, a population of Halicephalobus laticauda sp. n. was found in a water pit at 630 m below sea level in the coal mine of Winterslag. H. laticauda sp. n. differs from other Halicephalobus species by the broad tail with sclerotization at the tip and probably also by head and stoma structure. The detailed description is accompanied by drawings and scanning electron micrographs. The variation of several characters used in Halicephalobus identification is discussed for the described species. A key to the species is given. 11 refs., 1 fig.

  6. Highly Pathogenic Leptospira Found in Urban Brown Rats (Rattus norvegicus) in the Largest Cities of Sweden.

    Science.gov (United States)

    Strand, Tanja M; Löhmus, Mare; Persson Vinnersten, Thomas; Råsbäck, Therese; Sundström, Karin; Bergström, Tomas; Lundkvist, Åke

    2015-12-01

    Leptospirosis is an emerging zoonosis of global concern; however, its contemporary occurrence in Sweden, a European country partly located north of the Arctic Circle, is poorly known. Four out of 30 brown rats, captured within urban districts in Sweden, were found to be positive for antibodies to Leptospira interrogans serovar Icterohaemorrhagiae. This serovar causes Weil's disease in humans, a severe infection with jaundice, renal failure, and hemorrhage. Our study is the first finding of this highly pathogenic serovar in Swedish rats since the 1930s.

  7. The diegetic camera: narrative legibility and documental verisimilitude in found footage horror films

    Directory of Open Access Journals (Sweden)

    Rodrigo Carreiro

    2013-12-01

    Full Text Available ake found footage horror films have been massively made in the last two decades. To shoot a fictional script and give to it the texture of a documentary, a filmmaker has to deal with a number of creative restrictions in order to impose to images and sounds an effect of reality present in amateur footage. This essay examines recurring patterns of style, in this subgenre of movies, which have been used to combine narrative clarity and documental verisimilitude – a combination imposed by the presence of recording devices on the diegesis. 

  8. Lycodes adolfi Nielsen and Fosså, 1993 (Teleostei: Zoarcidae) found in the Arctic Ocean

    OpenAIRE

    Byrkjedal, Ingvar; Langhelle, Gunnar; de Lange Wenneck, Thomas; Wienerroither, Rupert

    2010-01-01

    Adolf’s eelpout, Lycodes adolW, was found at Wve bottom trawl stations in 2007–2009, on the slope towards the SoWa Deep north of Spitsbergen, at depths of 970–1,220 m and water temperatures below 0°C. Previously, the species has been known from cold and deep waters south of 74°N to both sides of Greenland and in the Norwegian Sea. The present material represents the Wrst records from the Arctic Ocean and may indicate a wider arctic distribution of this species.

  9. Deaminated UV filter 3-hydroxykynurenine O-beta-D-glucoside is found in cataractous human lenses.

    Science.gov (United States)

    Snytnikova, Olga A; Fursova, Anjella Zh; Chernyak, Elena I; Vasiliev, Vladimir G; Morozov, Sergey V; Kolosova, Nataliya G; Tsentalovich, Yuri P

    2008-06-01

    Analysis of UV filter levels in 48 cataractous human lenses was performed with the use of HPLC. A new chromophore with the absorption maximum at 410nm and molecular mass of 369Da was detected and assigned as deaminated 3-hydroxykynurenine O-beta-D-glucoside (3OHCKAG). Cataractous lenses are characterized by the wide range of the UV filter concentrations and remarkably lower levels of UV filters and glutathione than published for the normal lenses. No correlation between the lens age and the level of UV filters has been found in cataractous lenses.

  10. Complex Formation of Selected Radionuclides with Ligands Commonly Found in Ground Water: Low Molecular Organic Acids

    DEFF Research Database (Denmark)

    Jensen, Bror Skytte; Jensen, H.

    1985-01-01

    A general approach to the analysis of potentiometric data on complex formation between cations and polybasic amphoteric acids is described. The method is used for the characterisation of complex formation between Cs+, Sr2+, Co2+, La 3+, and Eu3+ with a α-hydroxy acids, tartaric acid and citric acid......, and with the α-amino acids, aspartic acid and L-cysteine. The cations have been chosen as typical components of reactor waste, and the acids because they are often found as products of microbial activity in pits or wherever organic material decays...

  11. A scream from the past: a multidisciplinary approach in a concealment of a corpse found mummified.

    Science.gov (United States)

    Gitto, Lorenzo; Bonaccorso, Luigi; Maiese, Aniello; dell'Aquila, Massimiliano; Arena, Vincenzo; Bolino, Giorgio

    2015-05-01

    When a mummified body is found, it requires the forensic pathologist to determine the manner and cause of death. The mummified body of an older man was found walled in an alcove in a silicon-sealed bedroom, in a semi-supine position with the back on the floor and the legs on the wall. Two plastic bags covered the body. Having removed the plastic bags, the body was fully wrapped in a brown adhesive tape. At the scene, there was no evidence of microfauna. The subject's son stated that after his father's death, he concealed the corpse in order to obtain his annual pension. A postmortem CT scan was performed before the autopsy, which excluded traumatic injuries. The autopsy together with the toxicological and microscopic findings helped us to understand the manner of death. In this case, the mummification process developed under specific environmental conditions and a multidisciplinary approach was required in order to solve it. Copyright © 2015 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved.

  12. Trinucleotide repeat expansion of spinocerebellar ataxia (SCA1) found in a Chinese family.

    Science.gov (United States)

    Cai, T; Yu, P; Chen, X; Lopa, M

    1998-02-01

    To investigate the gene mutation and the ratio of the spinocerebellar ataxia type 1 (SCA1) in Chinese patients with autosomal dominant spinocerebellar ataxia (ADSCA). The family material and DNA samples were collected from thirteen families with ADSCA. To determine the characteristics of the CAG trinucleotide repeats in SCA1 gene, the PCR products of the Rep1 and Rep2 primers were analyzed, and the bands with CAG repeat expansion were cloned by PCR2. 1 vector and sequenced. One family was found to have an expanded CAG repeat in the 13 families with ADSCA. The clinically affected individual was heterozygous with one disease allele being 55 CAG repeats, whereas the mean size of the CAG repeats on 104 chromosomes generated from unrelated control Chinese individuals is 29.3 (ranging from 18 to 34). The frequency of the SCA1 mutation is about 7% in the 13 Chinese families with ADSCA, suggesting that this type of genetic defect is not the main cause involved in the pathogenesis of ADSCA in China. Since the mutation has also been found in Caucasian, Japanese, Malaysian, and Bangladeshi kindreds, it is suggested that this genetic defect may well have multiple origins in different ethnic groups.

  13. DNA analysis of ancient dogs of the Americas: identifying possible founding haplotypes and reconstructing population histories.

    Science.gov (United States)

    Witt, Kelsey E; Judd, Kathleen; Kitchen, Andrew; Grier, Colin; Kohler, Timothy A; Ortman, Scott G; Kemp, Brian M; Malhi, Ripan S

    2015-02-01

    As dogs have traveled with humans to every continent, they can potentially serve as an excellent proxy when studying human migration history. Past genetic studies into the origins of Native American dogs have used portions of the hypervariable region (HVR) of mitochondrial DNA (mtDNA) to indicate that prior to European contact the dogs of Native Americans originated in Eurasia. In this study, we summarize past DNA studies of both humans and dogs to discuss their population histories in the Americas. We then sequenced a portion of the mtDNA HVR of 42 pre-Columbian dogs from three sites located in Illinois, coastal British Columbia, and Colorado, and identify four novel dog mtDNA haplotypes. Next, we analyzed a dataset comprised of all available ancient dog sequences from the Americas to infer the pre-Columbian population history of dogs in the Americas. Interestingly, we found low levels of genetic diversity for some populations consistent with the possibility of deliberate breeding practices. Furthermore, we identified multiple putative founding haplotypes in addition to dog haplotypes that closely resemble those of wolves, suggesting admixture with North American wolves or perhaps a second domestication of canids in the Americas. Notably, initial effective population size estimates suggest at least 1000 female dogs likely existed in the Americas at the time of the first known canid burial, and that population size increased gradually over time before stabilizing roughly 1200 years before present. Copyright © 2014 Elsevier Ltd. All rights reserved.

  14. Possibly Active Persistent Thymus Found in a Human Adult Cadaver – A Morpho-histological Study

    Directory of Open Access Journals (Sweden)

    Nayak SB

    2016-01-01

    Full Text Available Thymus is a bilobed organ usually situated in the superior mediastinum. Thymus is normally active until puberty and as age advances it undergoes considerable fibro-fatty degeneration and is replaced by fatty tissue. We found a persistent thymus in an adult male cadaver aged 70 years approximately. It apparently looked healthy. Hence the objective of this study was to know the morpho-histology of a persistent human thymus gland. Associated with this we also found a concurrent absence of isthmus of thyroid gland. Thymus obtained was processed according to the standard procedures and sections were stained with Haematoxylin & Eosin stain to study the age related changes of the thymus gland. Stained sections of thymus revealed a normal, healthy architecture of lobes of thymus. Knowledge regarding these morpho-histological features of the persistent thymus is important for clinicians and radiologists for the differential diagnosis of any mediastinal mass or presence of ectopic thymic tissue before doing any investigative procedure

  15. Biodegradation of pesticides using fungi species found in the aquatic environment.

    Science.gov (United States)

    Oliveira, B R; Penetra, A; Cardoso, V V; Benoliel, M J; Barreto Crespo, M T; Samson, R A; Pereira, V J

    2015-08-01

    Relatively limited attention has been given to the presence of fungi in the aquatic environment compared to their occurrence in other matrices. Taking advantage and recognizing the biodegradable capabilities of fungi is important, since these organisms may produce many potent enzymes capable of degrading toxic pollutants. Therefore, the aim of this study was to evaluate the potential ability of some species of filamentous fungi that occur in the aquatic environment to degrade pesticides in untreated surface water. Several laboratory-scale experiments were performed using the natural microbial population present in the aquatic environment as well as spiked fungi isolates that were found to occur in different water matrices, to test the ability of fungi to degrade several pesticides of current concern (atrazine, diuron, isoproturon and chlorfenvinphos). The results obtained in this study showed that, when spiked in sterile natural water, fungi were able to degrade chlorfenvinphos to levels below detection and unable to degrade atrazine, diuron and isoproturon. Penicillium citrinum, Aspergillus fumigatus, Aspergillus terreus and Trichoderma harzianum were found to be able to resist and degrade chlorfenvinphos. These fungi are therefore expected to play an important role in the degradation of this and other pollutants present in the aquatic environment.

  16. AUTHOR-SPECIFIC ADJECTIVES FOUND IN POETIC TEXTS BY CONTEMPORARY POETESSES

    Directory of Open Access Journals (Sweden)

    Olesya Alexandrovna Shkreba

    2017-06-01

    Full Text Available Purpose. This article is devoted to the analysis of author-specific adjectives as neologisms found in texts by contemporary poetesses. The author aims to both define derivational models for the formation of IAN adjectives and identify the features of the functioning of adjectives in the text. Methodology. The method of the system scientific description is used in the work, implying the use of the methods of multi-aspect systematization of author-specific neologisms in accordance with the research task. Comparative-comparative method, implemented in observation, comparison and theoretical interpretation of the results of the new language material analysis, allows drawing conclusions upon carrying out the research. Results. In the course of the conducted research it was revealed that author-specific adjectives, found in the texts by V. Polozkova, A. Kudryasheva, D. Balyko, A. Rivelote represent the most numerous group of authorial neologisms. Having been created by productive models of addition, suffixation and prefixation, these lexemes express new semantic nuances in poetic texts, thus reflecting the special state of the persona. Practical implications. The results of this study can be used at university in the pedagogical practice of language teachers in the framework of studying Neology as an academic discipline as well as in analyzing contemporary poetry.

  17. Palytoxin found in Palythoa sp. zoanthids (Anthozoa, Hexacorallia sold in the home aquarium trade.

    Directory of Open Access Journals (Sweden)

    Jonathan R Deeds

    Full Text Available Zoanthids (Anthozoa, Hexacorallia are colonial anemones that contain one of the deadliest toxins ever discovered, palytoxin (LD(50 in mice 300 ng/kg, but it is generally believed that highly toxic species are not sold in the home aquarium trade. We previously showed that an unintentionally introduced zoanthid in a home aquarium contained high concentrations of palytoxin and was likely responsible for a severe respiratory reaction when an individual attempted to eliminate the contaminant colonies using boiling water. To assess the availability and potential exposure of palytoxin to marine aquarium hobbyists, we analyzed zoanthid samples collected from local aquarium stores for palytoxin using liquid chromatography and high resolution mass spectrometry and attempted to identify the specimens through genetic analysis of 16S and cytochrome c oxidase 1 (COI markers. We found four specimens of the same apparent species of zoanthid, that we described previously to be responsible for a severe respiratory reaction in a home aquarium, to be available in three aquarium stores in the Washington D.C. area. We found all of these specimens (n = 4 to be highly toxic with palytoxin or palytoxin-like compounds (range 0.5-3.5 mg crude toxin/g zoanthid. One of the most potent non-protein compounds ever discovered is present in dangerous quantities in a select species of zoanthid commonly sold in the home aquarium trade.

  18. The development of scholarship in the Igakkan. (1) The founding of the Igakkan.

    Science.gov (United States)

    Machi, S

    1999-09-01

    The Igakkan was an institute for medical education in Tokugawa Japan, which was founded by Taki Motoaka (1693-1766) in 1765 and became a bakufu institution in 1791. This paper looks at the latter process (for the purpose of this abstract, I will refer to this as bureaucratization) in the context of Tokugawa educational policy, particularly in comparison with Shoheiko, a school for training bureaucrats. Also, this paper examines sources written during the Kansei period (1789-1801), many of which have been neglected in the field. I show that the Kansei reforms significantly shaped medical thought in the late Tokugawa period. The paper is divided into three parts, and will be published in this and the two forthcoming issues. The titles of the three parts are as follows: Part 1. The Founding of the Igakkan Part 2. Government doctors during the Kansei Reform Period, As Seen in Yoshino zoshi Part 3. The Place of Evidential Scholarship in the late Tokugawa Period. In Part 1, I show that while the Shoheiko confirmed Shushigaku (sometimes referred to as Neo-Confucianism) as an orthodoxy, supporting the existing political structure, the scholars in the Igakkan were never confined by Sushigaku.

  19. Yeasts found on an ephemeral reproductive caste of the leaf-cutting ant Atta sexdens rubropilosa.

    Science.gov (United States)

    Arcuri, Silvio Lovato; Pagnocca, Fernando Carlos; Melo, Weilan Gomes da Paixão; Nagamoto, Nilson Satoru; Komura, Dirce Leimi; Rodrigues, Andre

    2014-09-01

    Winged males of leaf-cutting ants are considered an ephemeral reproductive caste only produced before the mating flight season. Although much is known about the yeast diversity found in fungus gardens of attine ants, no study has focused on the yeasts associated with males of leaf-cutting ants. Here, we surveyed the yeasts on the integuments of males of Atta sexdens rubropilosa and assessed their potential role in the attine ant-microbe symbiosis. Using culture-dependent techniques, we found yeasts to be abundant on the integuments of males (54.5 %, n = 200 alates). A total of 242 yeast strains were obtained representing six orders, ten genera and 25 species. Strains of Aureobasidium, Cryptococcus, Hannaella and Rhodotorula were prevalent on the integuments and likely originated from the fungus garden of the parental nest or from the soil. The majority of strains (87.1 %) produced at least one of the evaluated enzymes: pectinase, polygalacturonase, cellulase, xylanase, ligninases and lipase. Aureobasidium pullulans accounted for the highest number of strains that produced all enzymes. In addition, yeasts showed the ability to assimilate the resulting oligosaccharides, supporting observations of other studies that yeasts may be involved in the plant biomass metabolism in the fungus gardens. Because winged males harbor several yeasts with putative functional roles, these fungi may take part and be beneficial in the microbial consortia of the new incipient nest.

  20. Similarities and differences between exome sequences found in a variety of tissues from the same individual.

    Science.gov (United States)

    Gómez-Ramos, Alberto; Sanchez-Sanchez, Rafael; Muhaisen, Ashraf; Rábano, Alberto; Soriano, Eduardo; Avila, Jesús

    2014-01-01

    DNA is the most stable nucleic acid and most important store of genetic information. DNA sequences are conserved in virtually all the cells of a multicellular organism. To analyze the sequences of various individuals with distinct pathological disorders, DNA is routinely isolated from blood, independently of the tissue that is the target of the disease. This approach has proven useful for the identification of familial diseases where mutations are present in parental germinal cells. With the capacity to compare DNA sequences from distinct tissues or cells, present technology can be used to study whether DNA sequences in tissues are invariant. Here we explored the presence of specific SNVs (Single Nucleotide Variations) in various tissues of the same individual. We tested for the presence of tissue-specific exonic SNVs, taking blood exome as a control. We analyzed the chromosomal location of these SNVs. The number of SNVs per chromosome was found not to depend on chromosome length, but mainly on the number of protein-coding genes per chromosome. Although similar but not identical patterns of chromosomal distribution of tissue-specific SNVs were found, clear differences were detected. This observation supports the notion that each tissue has a specific SNV exome signature.

  1. G. K. Batchelor. Founding editor of the Journal of Fluid Mechanics

    Science.gov (United States)

    Crighton, D. G.

    1999-05-01

    Although developments in fluid mechanics continue at a heady pace, and are reported in JFM at about 800 pages per month, things in the editorial management of JFM change only slowly. There is a continuity among the JFM Editorial Team and among the policies they espouse and implement that appears to be appreciated by the fluid mechanics community. A major change has, however, occurred from January 1999, in that George Batchelor has, after 43 years as Editor, stepped down from the day-to-day handling of papers and from the formulation of policies and practices, and allowed himself to be named on our masthead as Founding Editor. I say ‘allowed’ because George's initial wish was not to be so named, feeling that this might be seen as an immodest and presumptuous title. But Founding Editor is exactly what George was and is. He launched JFM in May 1956, having persuaded Taylor & Francis to be the publisher and printer, and having enlisted the help of G. F. Carrier, W. C. Griffith and M. J. Lighthill as Associate Editors, and T. Brooke Benjamin and I. Proudman as Assistant Editors. Then, as now, all members of the JFM Editorial Team were to work autonomously in the handling of papers, with complete delegated authority and similar workloads, but all following similar procedures and with similar philosophies, and all under the watchful eye of G. K. B.

  2. Psychological tensions found in suicide notes: a test for the strain theory of suicide.

    Science.gov (United States)

    Zhang, Jie; Lester, David

    2008-01-01

    As a comprehensive and parsimonious theory explaining the socio-psychological mechanism prior to suicidal behavior, strain theory of suicide postulates that conflicting and competing pressures in an individual's life usually precede a suicide. The theory proposes four sources of strain leading to suicide: (1) value strain from conflicting values, (2) aspiration strain from the discrepancy between aspiration and reality, (3) deprivation strain from relative deprivation such as poverty, and (4) coping strain from deficient coping skills in the face of a crisis. This research has content-analyzed 40 suicide notes (20 by suicide completers and 20 by suicide attempters) and found strong support for the strain theory of suicide. Although little difference is found in the number and pattern of strains between the completers and attempters, both groups have many aspirations and coping strains and few value and deprivation strains. Also, the older a suicidal victim is, the more he/she feels deprived and lacks coping skills and feels less bothered with value conflicts. Although the study has offered some support for the new theory, future research with more rigorous quantitative data needs to be conducted to further test the theory on a more comprehensive level.

  3. New Hybrids between Saccharomyces Sensu Stricto Yeast Species Found among Wine and Cider Production Strains

    Science.gov (United States)

    Masneuf, Isabelle; Hansen, Jørgen; Groth, Casper; Piskur, Jure; Dubourdieu, Denis

    1998-01-01

    Two yeast isolates, a wine-making yeast first identified as a Mel+ strain (ex. S. uvarum) and a cider-making yeast, were characterized for their nuclear and mitochondrial genomes. Electrophoretic karyotyping analyses, restriction fragment length polymorphism maps of PCR-amplified MET2 gene fragments, and the sequence analysis of a part of the two MET2 gene alleles found support the notion that these two strains constitute hybrids between Saccharomyces cerevisiae and Saccharomyces bayanus. The two hybrid strains had completely different restriction patterns of mitochondrial DNA as well as different sequences of the OLI1 gene. The sequence of the OLI1 gene from the wine hybrid strain appeared to be the same as that of the S. cerevisiae gene, whereas the OLI1 gene of the cider hybrid strain is equally divergent from both putative parents, S. bayanus and S. cerevisiae. Some fermentative properties were also examined, and one phenotype was found to reflect the hybrid nature of these two strains. The origin and nature of such hybridization events are discussed. PMID:9758815

  4. Palytoxin found in Palythoa sp. zoanthids (Anthozoa, Hexacorallia) sold in the home aquarium trade.

    Science.gov (United States)

    Deeds, Jonathan R; Handy, Sara M; White, Kevin D; Reimer, James D

    2011-04-04

    Zoanthids (Anthozoa, Hexacorallia) are colonial anemones that contain one of the deadliest toxins ever discovered, palytoxin (LD(50) in mice 300 ng/kg), but it is generally believed that highly toxic species are not sold in the home aquarium trade. We previously showed that an unintentionally introduced zoanthid in a home aquarium contained high concentrations of palytoxin and was likely responsible for a severe respiratory reaction when an individual attempted to eliminate the contaminant colonies using boiling water. To assess the availability and potential exposure of palytoxin to marine aquarium hobbyists, we analyzed zoanthid samples collected from local aquarium stores for palytoxin using liquid chromatography and high resolution mass spectrometry and attempted to identify the specimens through genetic analysis of 16S and cytochrome c oxidase 1 (COI) markers. We found four specimens of the same apparent species of zoanthid, that we described previously to be responsible for a severe respiratory reaction in a home aquarium, to be available in three aquarium stores in the Washington D.C. area. We found all of these specimens (n = 4) to be highly toxic with palytoxin or palytoxin-like compounds (range 0.5-3.5 mg crude toxin/g zoanthid). One of the most potent non-protein compounds ever discovered is present in dangerous quantities in a select species of zoanthid commonly sold in the home aquarium trade.

  5. Code Switching Used by English Lecturers During Teaching as Found in Padang State University

    Directory of Open Access Journals (Sweden)

    Widya Fhitri

    2017-05-01

    Full Text Available This research focuses on the study of the types of code switching and the reasons for lecturers to use the code switching that is based on Wardaugh’s theory and supported by Gumperz. The data was collected by using field method, with several steps, namely: following the lecturer, recording techniques, field recording, and interviews. From several data were examined, it was found three types of code switching. Conversations type is a type of code switching that often appear, followed by the type of situational and metaphorical. In addition, it was found seven reasons for the use of code switching in teaching and learning, namely the influence of students who first use the Indonesian language, ignorance of the students to the lecturers’ explanation , the emphasis on the previous statement, search the attention of the students because they make noise in the classroom, liquefaction the tense atmosphere with a little joke, forgetfulness some of the terms in English, and no equivalent word in English when giving an example of a lesson.

  6. Microsporidian Parasites Found in the Hemolymph of Four Baikalian Endemic Amphipods.

    Directory of Open Access Journals (Sweden)

    Ekaterina V Madyarova

    Full Text Available At present, approximately 187 genera and over 1300 species of Microsporidia have been described, among which almost half infect aquatic species and approximately 50 genera potentially infect aquatic arthropods. Lake Baikal is the deepest and one of the oldest lakes in the world, and it has a rich endemic fauna with a predominance of arthropods. Among the arthropods living in this lake, amphipods (Crustacea are the most dominant group and are represented by more than 350 endemic species. Baikalian amphipods inhabit almost all depths and all types of substrates. The age and geographical isolation of this group creates excellent opportunities for studying the diversity, evolution and genetics of host-parasite relationships. However, despite more than 150 years of study, data investigating the microsporidia of Lake Baikal remain incomplete. In this study, we used molecular genetic analyses to detect microsporidia in the hemolymph of several endemic species of amphipods from Lake Baikal. We provide the first evidence that microsporidian species belonging to three genera (Microsporidium, Dictyocoela and Nosema are present in the hemolymph of Baikalian endemic amphipods. In the hemolymph of Eulimnogammarus verrucosus, we detected SSU rDNA of microsporidia belonging to the genus Nozema. In the hemolymph of Pallasea cancellous, we found the DNA of Microsporidium sp. similar to that in other Baikalian endemic amphipods; Dictyocoela sp. was found in the hemolymph of Eulimnogammarus marituji and Acanthogammarus lappaceus longispinus.

  7. Microsporidian Parasites Found in the Hemolymph of Four Baikalian Endemic Amphipods.

    Science.gov (United States)

    Madyarova, Ekaterina V; Adelshin, Renat V; Dimova, Mariya D; Axenov-Gribanov, Denis V; Lubyaga, Yulia A; Timofeyev, Maxim A

    2015-01-01

    At present, approximately 187 genera and over 1300 species of Microsporidia have been described, among which almost half infect aquatic species and approximately 50 genera potentially infect aquatic arthropods. Lake Baikal is the deepest and one of the oldest lakes in the world, and it has a rich endemic fauna with a predominance of arthropods. Among the arthropods living in this lake, amphipods (Crustacea) are the most dominant group and are represented by more than 350 endemic species. Baikalian amphipods inhabit almost all depths and all types of substrates. The age and geographical isolation of this group creates excellent opportunities for studying the diversity, evolution and genetics of host-parasite relationships. However, despite more than 150 years of study, data investigating the microsporidia of Lake Baikal remain incomplete. In this study, we used molecular genetic analyses to detect microsporidia in the hemolymph of several endemic species of amphipods from Lake Baikal. We provide the first evidence that microsporidian species belonging to three genera (Microsporidium, Dictyocoela and Nosema) are present in the hemolymph of Baikalian endemic amphipods. In the hemolymph of Eulimnogammarus verrucosus, we detected SSU rDNA of microsporidia belonging to the genus Nozema. In the hemolymph of Pallasea cancellous, we found the DNA of Microsporidium sp. similar to that in other Baikalian endemic amphipods; Dictyocoela sp. was found in the hemolymph of Eulimnogammarus marituji and Acanthogammarus lappaceus longispinus.

  8. Simple pulmonary eosinophilia found on follow-up computed tomography of oncologic patients

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Sung Jung [Department of Radiology, Ajou University School of Medicine, Suwon (Korea, Republic of); Bista, Anjali Basnyat [Department of Radiology, B and B Hospital, Lalitpur (Nepal); Park, Kyung Joo; Kang, Doo Kyoung [Department of Radiology, Ajou University School of Medicine, Suwon (Korea, Republic of); Park, Joo Hun; Park, Kwang Joo [Department of Pulmonology and Critical Care Medicine, Ajou University School of Medicine, Suwon (Korea, Republic of); Sun, Joo Sung, E-mail: sunnahn@ajou.ac.kr [Department of Radiology, Ajou University School of Medicine, Suwon (Korea, Republic of)

    2014-10-15

    Objectives: To investigate the prevalence of simple pulmonary eosinophilia (SPE) and validate CT findings of SPE found on follow-up CT of oncologic patients. Methods: We retrospectively reviewed 6977 cases of oncologic patients who underwent chest CT. A total of 66 individuals who met criteria for having SPE were identified. CT scans were fully re-assessed by consensus of 2 radiologists in terms of characteristics of pulmonary lesions. Results: The prevalence of SPE was 0.95%. A total of 193 lesions were identified and most of the lesions showed part-solid pattern (69.9%), round to ovoid contour (46.1%), ill-defined margin (90.2%), or partial halo appearance (74.8%). In addition, almost half of the lesions showed the vascular contact (49%). SPE appeared as either solitary (42.4%) or multiple lesions (57.6%). The majority of lesions were located in the periphery (76.2%), and lower lung zonal (67.4%) predominance was found. Conclusions: The frequency of SPE in oncologic patients with CT findings of GGO, part-solid lesion was high (17.5%). Therefore, when key features of CT findings suggesting SPE (part-solid nodule; ill-defined margin; peripheral distribution; and lower lung zone predominance) are newly discovered on follow-up chest CT in oncologic patients, it would be useful to correlate with blood test and do short-term follow-up in order to avoid unnecessary invasive procedure.

  9. Microsporidian Parasites Found in the Hemolymph of Four Baikalian Endemic Amphipods

    Science.gov (United States)

    Madyarova, Ekaterina V.; Adelshin, Renat V.; Dimova, Mariya D.; Axenov-Gribanov, Denis V.; Lubyaga, Yulia A.; Timofeyev, Maxim A.

    2015-01-01

    At present, approximately 187 genera and over 1300 species of Microsporidia have been described, among which almost half infect aquatic species and approximately 50 genera potentially infect aquatic arthropods. Lake Baikal is the deepest and one of the oldest lakes in the world, and it has a rich endemic fauna with a predominance of arthropods. Among the arthropods living in this lake, amphipods (Crustacea) are the most dominant group and are represented by more than 350 endemic species. Baikalian amphipods inhabit almost all depths and all types of substrates. The age and geographical isolation of this group creates excellent opportunities for studying the diversity, evolution and genetics of host-parasite relationships. However, despite more than 150 years of study, data investigating the microsporidia of Lake Baikal remain incomplete. In this study, we used molecular genetic analyses to detect microsporidia in the hemolymph of several endemic species of amphipods from Lake Baikal. We provide the first evidence that microsporidian species belonging to three genera (Microsporidium, Dictyocoela and Nosema) are present in the hemolymph of Baikalian endemic amphipods. In the hemolymph of Eulimnogammarus verrucosus, we detected SSU rDNA of microsporidia belonging to the genus Nozema. In the hemolymph of Pallasea cancellous, we found the DNA of Microsporidium sp. similar to that in other Baikalian endemic amphipods; Dictyocoela sp. was found in the hemolymph of Eulimnogammarus marituji and Acanthogammarus lappaceus longispinus. PMID:26087136

  10. Follow-up of patients with systemic lupus erythematosus: what is not found in the guidelines.

    Science.gov (United States)

    Jiménez-Alonso, J; Vargas-Hitos, J A; Navarrete-Navarrete, N; Zamora-Pasadas, M; Aguilar-Huergo, S; Jáimez, L; Sabio, J M

    2013-12-01

    A series of measures in the management of patients with systemic lupus erythematosus (SLE) which usually are not found in the lupus guidelines are discussed. In the lupus patient who has been well-controlled in the long term, the dose of hydroxychloroquine should be progressively reduced, without decreasing more than approximately 600 mg per week. We recommend taking this drug in the morning in patients with insomnia, at night in those with dyspepsia and to separate the intake of the drug from the shower (and the water should be as cool as possible) in those patients with aquagenic pruritus. We do not use prednisone on alternate days and exceptionally divide the dose into ¾ before breakfast and ¼ before dinner. Twenty to 30 min should be used per patient in every scheduled visit to assure a good clinical and human practice. We analyzed the follow-up of 112 consecutive patients from our systemic disease unit and found that 71.4% of them had symptoms that were unexplained by lupus and we only referred 8.9% of them to other specialists, probably because of our general training as internal medicine doctors. We suggest that knowing the views of SLE specialists might be of interest since, well-designed studies that would allow to progress in the understanding of this disease could be performed based on their experience. Copyright © 2013 Elsevier España, S.L. All rights reserved.

  11. Possible sources of archaeological maize found in Chaco Canyon and Aztec Ruin, New Mexico

    Science.gov (United States)

    Benson, L.V.; Stein, J.R.; Taylor, H.E.

    2009-01-01

    Maize played a major role in Chaco's interaction with outlying communities in the southern Colorado Plateau. This paper seeks to determine where archaeological corn cobs brought to Chaco Canyon were grown. Strontium-isotope and trace-metal ratios of 180 soil-water and 18 surface-water sites in the Southern Colorado Plateau have revealed possible source areas for some of 37 archaeological corn cobs from Chaco Canyon and 10 archaeological corn cobs from Aztec Ruin, New Mexico. The most probable source areas for cobs that predate the middle-12th-century drought include several Upper Rio Chaco sites (not including Chaco Canyon). There are many potential source areas for cobs that date to the late A.D. 1100s and early 1200s, all of which lie in the eastern part of the study area. Some Athapascan-age cobs have potential source areas in the Totah, Lobo Mesa, and Dinetah regions. One Gallo Cliff Dwelling cob has a strontium-isotope ratio that exceeds all measured soil-water values. Field sites for this cob may exist in association with Paleozoic and Precambrian rocks found 80-90 km from Chaco Canyon. Potential source areas for most Aztec Ruin cobs (many of which were found in rooms dating to the first half of the 13th-century) appear to be associated with a loess deposit that blankets the Mesa Verde and McElmo Dome regions.

  12. Phylogenetic relationship of Hepatozoon blood parasites found in snakes from Africa, America and Asia.

    Science.gov (United States)

    Haklová, B; Majláthová, V; Majláth, I; Harris, D J; Petrilla, V; Litschka-Koen, T; Oros, M; Peťko, B

    2014-03-01

    The blood parasites from the genus Hepatozoon Miller, 1908 (Apicomplexa: Adeleida: Hepatozoidae) represent the most common intracellular protozoan parasites found in snakes. In the present study, we examined 209 individuals of snakes, from different zoogeographical regions (Africa, America, Asia and Europe), for the occurrence of blood parasites using both molecular and microscopic examination methods, and assess phylogenetic relationships of all Hepatozoon parasites from snakes for the first time. In total, 178 blood smears obtained from 209 individuals, representing 40 species, were examined, from which Hepatozoon unicellular parasites were found in 26 samples (14·6% prevalence). Out of 180 samples tested by molecular method polymerase chain reaction (PCR), the presence of parasites was observed in 21 individuals (prevalence 11·6%): 14 snakes from Africa belonging to six genera (Dendroaspis, Dispholidus, Mehelya, Naja, Philothamnus and Python), five snakes from Asia from the genus Morelia and two snakes from America, from two genera (Coluber and Corallus). The intensity of infection varied from one to 1433 infected cells per 10 000 erythrocytes. Results of phylogenetic analyses (Bayesian and Maximum Likelihood) revealed the existence of five haplotypes divided into four main lineages. The present data also indicate neither geographical pattern of studied Hepatozoon sp., nor congruency in the host association.

  13. Alpha thalassemia deletions found in suspected cases of beta thalassemia major in Pakistani population.

    Science.gov (United States)

    Shahid, Saba; Nadeem, Muhammad; Zahid, Danish; Hassan, Jawad; Ansari, Saqib; Shamsi, Tahir

    2017-01-01

    Alpha (α) thalassemia is a hereditary disorder and is caused by deletions or mutations in globin genes. It is present in two clinically significant forms: hemoglobin Bart hydrops fetalis (Hb Bart) syndrome and hemoglobin H (HbH) disease. It is highly prevalent in South-East Asia or Mediterranean countries. The most common deletion reported in alpha thalassemia in Pakistani population was -α3.7 with a frequency of 8.3%, and the rare forms were -α4.2 (0.2%) and αααanti3.7 (0.9%). In our study, diagnosis of severe anemia cases without any α and β mutations or deletions were made by using extended alpha thalassemia deletions panel. The main objective of this study was to determine the prevalence and to study the spectra of alpha thalassemia gene deletions in beta thalassemia patients with the use of an extended panel including --SEA, --FIL, --MED, --20.5, --THAI in addition to -α3.7, -α4.2 & -αααanti3.7. The samples were collected in ethylenediaminetetraacetic acid (EDTA) vacutainers. A total of 156 samples were analyzed for alpha thalassemia mutations. This cohort included 121 samples of beta thalassemia major, nine samples of beta thalassemia minor and 26 without any evidence of beta thalassemia mutations. DNA was extracted with Qiagen extraction kit. The primers for determination of different subsets of alpha thalassemia deletions were included. PCR amplification was performed and result interpreted on agarose gel. Co-inheritance of alpha thalassemia (-α3.7, -α4.2) with homozygous beta thalassemia was detected in 30% cases of studied cohort (37 out of 121). The most common found was -α3.7 deletion (35/37) as single/double deletions or in combination with -αααanti3.7. In undiagnosed cases screened for beta thalassemia major, we found Mediterranean (-αMED) deletion at specifically 875 bp on agarose gel. This is distinctive finding in case of detecting -αMED instead of any other deletion from Pakistan. Alpha thalassemia deletions (-α3.7, -α4

  14. Seventeenth-century 'treasure' found in Royal Society archives: the Ludus helmontii and the stone disease.

    Science.gov (United States)

    Alfonso-Goldfarb, Ana Maria; Ferraz, Márcia Helena Mendes; Rattansi, Piyo M

    2014-09-20

    Our archival researches at the Royal Society reveal that a small envelope attached to a 1675 letter from an Antwerp apothecary, A. Boutens, contained a sample of the 'Ludus' prepared as a remedy for the 'stone disease' then sweeping through Europe, which was first announced in J. B. van Helmont's De lithiasi (1644). After examining the fascination with the medical use of the Ludus (which required the 'alkahest' for its preparation) and the tenacious efforts to procure it, we trace the fortunae of two other ludi in England, brought to and offered by Francis Mercurius van Helmont during his English sojourn. Both eventually found their way to the geologist John Woodward, one of them through Sir Isaac Newton. Finally we show how the allure of the Ludus helmontii vanished, with transformations in mineral analysis and reclassifications from Woodward to John Hill.

  15. Explorations on Temperature, Oxygen, Nutrients and Habitat Demands of Fish Species Found in River Coruh

    Directory of Open Access Journals (Sweden)

    Bilal Akbulut

    2009-04-01

    Full Text Available For the protection of our natural resources, fish species being economic and ecological richness of the natural in the basin of the Çoruh to know their request is extremely a vital important issue. In this study, temperature and oxygen demand, food and habitat of 18 fish species in six families found in river Çoruh assessed and discussed with the literature and database. Limiting the impact of water temperature on the reproductive, growth and nutrition emphasized. The fish species in the basin spawn at temperatures between 14-30°C according to database. Three species belonging to a family feed with animal food floating in the water. The species belonging to the other families more feed mixed with plant and animal foods diet in the floor or near the ground. Importance of their environmental demands has clarified for conservation and sustainable use of these fish species inhabiting in Çoruh River.

  16. Multilamellar Structures and Filament Bundles Are Found on the Cell Surface during Bunyavirus Egress

    Science.gov (United States)

    Sanz-Sánchez, Laura; Risco, Cristina

    2013-01-01

    Inside cells, viruses build specialized compartments for replication and morphogenesis. We observed that virus release associates with specific structures found on the surface of mammalian cells. Cultured adherent cells were infected with a bunyavirus and processed for oriented sectioning and transmission electron microscopy. Imaging of cell basal regions showed sophisticated multilamellar structures (MLS) and extracellular filament bundles with attached viruses. Correlative light and electron microscopy confirmed that both MLS and filaments proliferated during the maximum egress of new viruses. MLS dimensions and structure were reminiscent of those reported for the nanostructures on gecko fingertips, which are responsible for the extraordinary attachment capacity of these lizards. As infected cells with MLS were more resistant to detachment than control cells, we propose an adhesive function for these structures, which would compensate for the loss of adherence during release of new virus progeny. PMID:23799021

  17. An illustrated guide to seeds found in nests of the Florida harvester ant, Pogonomyrmex badius.

    Science.gov (United States)

    Tschinkel, Walter R; Domínguez, Daniel J

    2017-01-01

    The Florida harvester ant, Pogonomyrmex badius collects the seeds of many plant species and stores them in underground nest chambers for later consumption. Seeds taken from multiple nests in 1989, 2014 and 2015 were separated by size and species and identified through published keys, comparison with herbarium specimens and with identified seed collections. Harvester ants stored at least 58 species of seeds from 20 plant families in their chambers. This paper presents images of each seed species in several aspects, their relative abundance in P. badius nests, their size relative to the smallest, and links to online data and images of the parent plant species, as well as to herbarium specimens. A number of seeds and plant families present at the site were not found in ant nests. These data and images will be valuable for future studies and experiments to untangle the choices the ants make in relation to what the plants and the seasons offer them.

  18. AMERICAN CONSERVATIVE MOVEMENT OF THE TEA PARTY IN 2009: A CONCEPT OF FOUNDING

    Directory of Open Access Journals (Sweden)

    Didik Murwantono

    2013-10-01

    Full Text Available The awakening of American conservative movement like The Tea Party in the beginning of 2009 was a phenomenon as a reaction against Obama‘s Democratic presidency. American conservative movements have never been the same but they maintain a strong tradition. Historically, they have emerged and then died out. This research offers a concept of ‘founding’ for dealing with social changes and the political transformation of The Tea Party phenomenon. It adopts descriptive qualitative methods and applies Event Structure Analysis supported by Founding and Social Change theories. In general, American conservative movements have never been successful; however they have affected policy changes within the government and the political parties in the United States. They are known to be inconsistent, yet it seems likely that they will continue to evolve.

  19. Intestinal ciliate composition found in the feces of racing horses from Izmir, Turkey.

    Science.gov (United States)

    Gürelli, Gözde; Göçmen, Bayram

    2012-08-01

    Species composition and distribution of intestinal ciliates were investigated in the feces from 15 racing horses living near Izmir, Turkey. Thirty-seven species belonging to 21 genera were identified. Although no new species were observed, this is the first report on intestinal ciliates in racing horses living in Turkey. The mean number of ciliates was 26.4 ± 13.9 × 10(4) cells ml(-1) of feces and the mean number of ciliate species per host was 18.8 ± 7.1. No ciliates were observed in one horse. Bundleia and Polymorphella were found to be the two dominant genera, occurring in high proportions. In contrast, Didesmis and Prorodonopsis were only observed at a low frequency. Bundleia nana, Blepharoconus hemiciliatus, Paraisotrichopsis composita, Prorodonopsis coli and Spirodinium equi were newly recorded from Turkey. Copyright © 2012 Elsevier GmbH. All rights reserved.

  20. Found in translation; from the laboratory to the operating room to the market.

    Science.gov (United States)

    Galloway, Robert L

    2007-01-01

    Translation is a term, of late, frequently used in medical research. It means different things to different people. For some it is moving from conception to science and engineering to application; for others it means moving technological development into the treatment of patients; and for still others it means moving a research development into a commercial system. In 2004 in a pique of frustration with big medical device companies and academic administrators, I founded a spin-off company from my laboratory to take a development of ours to the market place. The company, Pathfinder Therapeutics Inc., as of this writing, is still in business so I presume it can be defined as a success. We have faced each of the above defined translation challenges and more remain. The presentation (and paper) will cover the process of achieving that success and of lessons often painfully learned.

  1. Use of the intraosseous screw for unilateral upper molar distalization and found well balanced occlusion

    Directory of Open Access Journals (Sweden)

    Buyukyilmaz Tamer

    2006-11-01

    Full Text Available Abstract Background The aim of this study was to present a temporary anchorage device with intraosseous screw for unilateral molar distalization to make a space for the impacted premolar and to found well balanced occlusion in a case. Case presentation A 13-year-old male who have an impacted premolar is presented with skeletal Class I and dental Class 2 relationship. The screw was placed and immediately loaded to distalize the left upper first and second molar. The average distalization time to achieve an overcorrected Class I molar relationship was 3.6 months. There was no change in overjet, overbite, or mandibular plane angle measurements. Mild protrusion (0.5 mm of the upper left central incisor was also recorded. Conclusion Immediately loaded intraosseous screw-supported anchorage unit was successful in achieving sufficient unilateral molar distalization without anchorage loss. This treatment procedure was an alternative treatment to the extraction therapy.

  2. Differential radiologic diagnosis of the spherical shades found in the maxillary sinus

    Energy Technology Data Exchange (ETDEWEB)

    Vorob' ev, Yu.I.; Litvakovskaya, G.A.; Bogdashevskaya, V.B.; Buzanov, V.A. (Moskovskij Meditsinskij Stomatologicheskij Inst. (USSR))

    Data obtained during clinical and radiologic examination of 203 patients have been analysed. It was found that the error percentage in diagnosis of the spherical shades in the maxillary sinuses reaches 22% according to plain radiography of the nasal sinuses. A radiologic sympton of the spherical shade in the lumen of the maxillary sinus may be detected either in bening processes (retentive and odontogenic cysts, bening tumors, fibrous dysplasia of the jaws, etc.), or in malignant tumors, originating from the alveolar process area and the hard palate. Some radiologic signs of the most common diseases, accompanied by the sherical shade sympton in the lumen of the maxillary sinus, are described. A verification of both localization and nature of pathologic process in the maxillary sinus is carried out by means of multiposition craniography and various modifications of the stratifying X-ray examination.

  3. Glucosinolates, myrosinase hydrolysis products, and flavonols found in rocket (Eruca sativa and Diplotaxis tenuifolia).

    Science.gov (United States)

    Bell, Luke; Wagstaff, Carol

    2014-05-21

    Rocket species have been shown to have very high concentrations of glucosinolates and flavonols, which have numerous positive health benefits with regular consumption. This review highlights how breeders and processors of rocket species can utilize genomic and phytochemical research to improve varieties and enhance the nutritive benefits to consumers. Plant breeders are increasingly looking to new technologies such as HPLC, UPLC, LC-MS, and GC-MS to screen populations for their phytochemical content to inform plant selections. This paper collates the research that has been conducted to date in rocket and summarizes all glucosinolate and flavonol compounds identified in the species. The paper emphasizes the importance of the broad screening of populations for phytochemicals and myrosinase degradation products, as well as unique traits that may be found in underutilized gene bank resources. This review also stresses that collaboration with industrial partners is becoming essential for long-term plant breeding goals through research.

  4. Six-hydroxydopamine induced hyperactivity: neither sex differences nor caffeine stimulation are found.

    Science.gov (United States)

    Erinoff, L; Kelly, P H; Basura, M; Snodgrass, S R

    1984-05-01

    We investigated possible sex differences in the development of locomotor activity in rats treated neonatally with desmethylimipramine (DMI) followed by intraventricular 6-hydroxydopamine (6-HDA). In addition, the locomotor response to the stimulant caffeine was investigated in the male rats after they had reached adulthood. Both male and female 6-HDA-treated rats exhibited increased activity relative to controls. No sex differences were seen in either the development or magnitude of this effect. Male rats were used to determine the dose effects function for caffeine (0.5, 5, 15, 30 mg/kg) on locomotor activity. Control rats exhibited increased locomotor activity whereas 6-HDA-treated rats showed no increases with any dose of caffeine. Large decreases in the dopamine content of the olfactory tubercle (-88%, -82%), nucleus accumbens (-96%, -95%), and striatum (-99%, -99%) were found in both male and female rats. Choline acetyltransferase and glutamic acid decarboxylase activities were unchanged.

  5. DISC1 exon 11 rare variants found more commonly in schizoaffective spectrum cases than controls.

    Science.gov (United States)

    Green, E K; Grozeva, D; Sims, R; Raybould, R; Forty, L; Gordon-Smith, K; Russell, E; St Clair, D; Young, A H; Ferrier, I N; Kirov, G; Jones, I; Jones, L; Owen, M J; O'Donovan, M C; Craddock, N

    2011-06-01

    We previously performed a linkage study using families identified through probands meeting criteria for DSM-IV schizoaffective disorder, bipolar type (SABP) and observed a genome-wide significant signal (LOD = 3.54) at chromosome 1q42 close to DISC1. An initial sequencing study of DISC1 using 14 unrelated DSM-IV SABP samples from the linkage study identified 2 non-synonymous coding SNPs in exon 11 in 2 separate individuals. Here we provide evidence of additional rare coding SNPs within exon 11. In sequencing exon 11 in 506 cases and 1,211 controls for variants that occurred only once, 4 additional rare variants were found in cases (P-value = 0.008, Fisher's exact trend test). Copyright © 2011 Wiley-Liss, Inc.

  6. Double standards: Standards of proof for persons found unfit for trial.

    Science.gov (United States)

    O'Carroll, Betheli

    2015-06-01

    This article examines the laws surrounding whether a court has to be satisfied that a person who is unfit for trial committed an offence. Currently in Western Australia, Queensland, the Commonwealth and New Zealand, there is one standard of proof for persons who are fit for trial and a different, or no, standard of proof for persons found unfit. In particular, in Western Australia and Queensland, courts do not have to be satisfied to any standard of proof that a person who is unfit for trial committed an offence. This practice is of concern as unfit persons in these jurisdictions may be subject to custody orders or be involuntarily detained without having been convicted of an offence. The legislation in these jurisdictions is compared with the legislation in the remaining Australian jurisdictions where courts need to be satisfied beyond reasonable doubt that a person who is unfit for trial committed the conduct or objective elements of the alleged offence.

  7. Reducing Communication Apprehension for New Patients Through Information Found Within Physicians' Biographies.

    Science.gov (United States)

    Perrault, Evan K; Silk, Kami J

    2015-01-01

    This study investigated whether state communication apprehension (CA) with physicians, for high CA patients, can be reduced before consultations by manipulating information found within physicians' online biographies. Participants were presented with three experimentally manipulated physician biographies and asked to choose which physician they would want to visit to get a hypothetical ailment checked out. Guided by uncertainty reduction theory, results support a path model where increases in perceived similarities between a patient and doctor led to greater uncertainty reduction, greater liking, and subsequent reductions in CA with the physician for high CA participants. In addition, the majority of participants decided to visit the physician with whom they perceived the greatest similarity. The importance of reducing CA in the medical context is discussed, as well as theoretical implications for communication researchers. The results also provide practical guidance for health care systems to help improve their current physician biographical offerings available to prospective patients.

  8. Antimicrobial activity of Arctium lappa constituents against microorganisms commonly found in endodontic infections.

    Science.gov (United States)

    Pereira, Juliana Vianna; Bergamo, Débora Cristina Baldoqui; Pereira, José Odair; França, Suzelei de Castro; Pietro, Rosemeire Cristina Linhares Rodrigues; Silva-Sousa, Yara T Corrêa

    2005-01-01

    This study evaluated in vitro the antimicrobial activity of rough extracts from leaves of Arctium lappa and their phases. The following microorganisms, commonly found in the oral cavity, specifically in endodontic infections, were used: Enterococcus faecalis, Staphylococcus aureus, Pseudomonas aeruginosa, Bacillus subtilis and Candida albicans. The agar-diffusion method allowed detection of the hexanic phase as an inhibitor of microbial growth. Bioautographic assays identified antimicrobial substances in the extract. The results showed the existence, in the rough hexanic phase and in its fractions, of constituents that have retention factors (Rf) in three distinct zones, thereby suggesting the presence of active constituents with chemical structures of different polarities that exhibited specificity against the target microorganisms. It may be concluded that the Arctium lappa constituents exhibited a great microbial inhibition potential against the tested endodontic pathogens.

  9. IL-27 Found to Play Significant Role in Conferring HIV Resistance | Poster

    Science.gov (United States)

    By Nancy Parrish, Staff Writer The human immunodeficiency virus (HIV) targets specific immune cells in the body known as macrophages because these are the cells that eliminate foreign material such as bacteria or viruses. HIV is able to reproduce and spread throughout the body if it can avoid destruction by macrophages. A recent study by Lue Dai, Ph.D., and colleagues revealed that the human cytokine IL-27 helps promote the body’s production of macrophages that are resistant to HIV. The study further found that IL-27 suppresses a gene known as SPTBN1, which facilitates the survival of HIV cells. This breakthrough research was recently published in the Journal of Experimental Medicine.

  10. A mysterious case of gastroparesis: could the secret be found in a drink?

    Science.gov (United States)

    Principi, Mariabeatrice; Nunzio, Ranaldo; Ingravallo, Giuseppe; Riezzo, Giuseppe; Damiani, Elisabetta; Ferrannini, Antonio; Rossi, Roberta; Resta, Leonardo; Ierardi, Enzo; Di Leo, Alfredo

    2013-06-01

    Gastroparesis is a disorder characterized by delayed gastric emptying of a meal in the absence of a mechanical gastric outlet obstruction. Idiopathic gastroparesis is at least as common as diabetic gastroparesis in most case series, and the true prevalence of gastroparesis is unknown. We report here an interesting case of idiopathic gastroparesis characterized by sudden onset in a female patient. The diagnosis was confirmed by ultrasonographic study of gastric emptying and electrogastrography, by gastric endoscopy/histology, and finally by allergy tests. The disorder was found to be due to a rare cause, namely an allergic predisposition. In fact, our patient, who demonstrated an allergy to gold salts, had drunk a glass of a liqueur containing gold flakes and developed an eosinophilic aggregation in the gastric mucosa observed at gastric endoscopy/histology. The symptoms disappeared after steroid administration. Our experience suggests that gastric histology and close enquiry into any history of allergy may be useful diagnostic tools in cases of idiopathic gastroparesis.

  11. Alterations of skull bones found in anencephalic skeletons from an identified osteological collection. Two case reports.

    Science.gov (United States)

    Irurita, Javier; Alemán, Inmaculada; Viciano, Joan; López-Lázaro, Sandra; Botella, Miguel Cecilio

    2015-07-01

    One of the most common conditions during fetal development is anencephaly, which often involves many identification difficulties in the context of physical anthropology, as it causes severe skull challenges. In this paper, we describe the alterations found in the skulls of two perinatal individuals with anencephaly from the osteological collection of identified infants in the Anthropology Laboratory of the University of Granada, Spain. Both subjects of study are in perfect state of preservation. Despite the severe malformations, all skull bones have been targeted and identified, as the possibility of studying a subject with a complete, articulated, and partially mummified skull; the other was disjointed and well preserved. The skull bones of these two individuals affected with anencephaly have been described in detail, allowing this pathological condition to be identified in skeletonized individuals in archaeological or forensic contexts, in cases where these bones did not have anatomical connection or when these were taphonomically altered.

  12. Hydroxylation of a hederagenin derived saponin by a Xylareaceous fungus found in fruits of Sapindus saponaria

    Energy Technology Data Exchange (ETDEWEB)

    Murgu, Michael; Santos, Luiz F. Arruda; Souza, Gezimar D. de; Daolio, Cristina; Ferreira, Antonio Gilberto; Rodrigues-Filho, Edson [Universidade Federal de Sao Carlos (UFSCAR), SP (Brazil). Dept. de Quimica; Schneider, Bernd [Max Planck Institute for Chemical Ecology, Beutenberg Campus, Jena (Germany)

    2008-07-01

    During our screening of tropical plants for endophyte microorganisms, a Xylareaceous fungus was found living on the internal part of Sapindus saponaria fruits. The fruits of S. saponaria accumulate great amounts of triterpenoidal and sesquiterpenoidal saponins. The saponin 3-O-({beta}-D-xylopyranosyl)-(1{yields}3)-{alpha}-L -rhamnopyranosyl-(1{yields}2)-{alpha}-L-arabinopyranosyl-hederagenin was isolated using chromatographic methods, after alkaline hydrolysis of the crude extract obtained from S. saponaria fruits and added to the culture medium used to grows the fungus. A new saponin was isolated from this experiment by preparative scale HPLC and characterized as a 22{alpha}-hydroxy derivative. The structure of this hydroxylated saponin was elucidated based on interpretation of MS/MS data and NMR spectra. (author)

  13. Etiologic Agents and Diseases Found Associated with Clinical Aspergillosis in Falcons

    Directory of Open Access Journals (Sweden)

    Walter Tarello

    2011-01-01

    Full Text Available The aim of this study was to describe parasitological, microbiological, and pathological findings associated with the isolation of Aspergillus species in 94 clinically diseased captive falcons from Dubai. Concomitant agents and/or diseases were identified in 64 cases, causing either single (=36 or multiple coinfections (=28. Diagnoses found more often in association with aspergillosis were chronic fatigue and immune dysfunction syndrome (CFIDS (=29, Caryospora sp. (=16, Serratospiculum seurati infestation (=14, cestodiasis (=6, bumblefoot (=5, trematodosis due to Strigea falconispalumbi (=5, trichomoniasis (=4, Babesia shortti (=4, Mannheimia (Pastorella haemolytica (=4, interstitial hepatitis (=4, Escherichia coli (=3, and Clostridium perfringens enterotoxemia (=2. Compared with a control group of 2000 diseased falcons without evidence of aspergillosis, the prevalence of Babesia shortti, CFIDS, Mannheimia (Pastorella haemolytica, Escherichia coli, and falcon herpes virus infection was conspicuously higher in association with aspergillosis. These entities may be considered suitable candidates as predisposing factors for the mycosis.

  14. Non-accidental injuries found in necropsies of domestic cats: a review of 191 cases.

    Science.gov (United States)

    de Siqueira, Adriana; Cassiano, Fabiana Cecília; de Albuquerque Landi, Marina Frota; Marlet, Elza Fernandes; Maiorka, Paulo César

    2012-10-01

    Animal cruelty is defined as a deliberate action that causes pain and suffering to an animal. In Brazil, legislation known as the Environmental Crimes Law states that cruelty toward all animal species is criminal in nature. From 644 domestic cats necropsied between January 1998 and December 2009, 191 (29.66%) presented lesions highly suggestive of animal cruelty. The main necroscopic finding was exogenous carbamate poisoning (75.39%) followed by blunt-force trauma (21.99%). Cats from 7 months to 2 years of age were the most affected (50.79%). In Brazil, violence is a public health problem and there is a high prevalence of domestic violence. Therefore, even if laws provide for animal welfare and protection, animals are common targets for violent acts. Within a context of social violence, cruelty toward animals is an important parameter to be considered, and the non-accidental lesions that were found are evidence of malicious actions.

  15. Between Cratylism and positivism: the old poem and what Alice found there

    Directory of Open Access Journals (Sweden)

    Amadeu Viana

    2004-12-01

    Full Text Available In this paper I shall refer summarily to nineteenth century philology in an attempt to relate it with the wordplay found in the works of Lewis Carroll in order to establish a correct range of (discontinuities. My aim is to consider the Jabberwocky of Humpty Dumpty within the context of modern philological studies and discoveries. F. A. Wolf and J. Grimm condense a good part of the radical experiments and findings that occurred at that time which can now be contrasted with the textualized adventures of Alice on the other side of the mirror. The looking-glass books need interpreters and seek their correct, original versions just as the interpretation of the words depends on a trustworthy methodology. Surely, as a young philologist, Lewis Carroll was well able to play with those findings, between the world that was ending and that which had just begun. (English text.

  16. Analysis and Measurements of Artificial Optical Radiation (AOR Emitted by Lighting Sources Found in Offices

    Directory of Open Access Journals (Sweden)

    Francesco Leccese

    2014-09-01

    Full Text Available In this paper the authors describe in detail the exposure limit values concerning artificial optical radiation due to the main incoherent light sources found in offices. In particular, for some examples of significant sources chosen as case studies, we discuss the results of in situ measurements of the exposure values using a broadband photoradiometer. By comparing the measurement results with the exposure limit values specified in the European legislation, the maximum exposure times for workers have been evaluated. From the analysis of the results it can be concluded that the lighting sources typically present in indoor workplaces under usual conditions of use, do not pose a health risks for workers. However, in the case of accidental exposure during work activities or exposure linked to maintenance activities (short exposure distance, values in excess of the limit values have been observed, with decidedly short maximum exposure times.

  17. P elements are found in the genomes of nematoceran insects of the genus Anopheles.

    Science.gov (United States)

    Sarkar, A; Sengupta, R; Krzywinski, J; Wang, X; Roth, C; Collins, F H

    2003-04-01

    We report the identification of genomic sequences in various anopheline mosquitoes (family Culicidae: suborder Nematocera: order Diptera) showing homology to the class II, short inverted-terminal-repeat (ITR) transposable element P from Drosophila melanogaster (family Drosophilidae; suborder Brachycera: order Diptera). Anopheles gambiae appears to have at least six distinct P elements. Other anopheline species, including four additional members of the An. gambiae species complex (An. arabiensis, An. merus, An. melas and An. quadriannulatus), Anopheles stephensi (all subgenus Cellia), An. quadrimaculatus (subgenus Anopheles) and Anopheles albimanus (subgenus Nyssorhynchus) also possess P elements similar to those found in An. gambiae. Ten distinct P element types were identified in the genus Anopheles. At least two of the An. gambiae elements appears to be intact and potentially functional. Phylogenetic analysis of the anopheline P elements reveals them to belong to a distinctly different clade from the brachyceran P elements.

  18. A systematic review found no consistent difference in effect between more and less intensive placebo interventions

    DEFF Research Database (Denmark)

    Fässler, Margrit; Meissner, Karin; Kleijnen, Jos

    2015-01-01

    OBJECTIVES: It has been suggested that some placebo interventions might be associated with larger clinical effects than others. In a systematic review, we investigated whether there is evidence from direct comparisons in randomized clinical trials including two or more placebo groups supporting...... intense and the less intense placebo intervention, four studies found differences for single outcomes, and one study consistently reported significantly larger effects of the more intense placebo. An explorative meta-analysis yielded a standardized mean difference -0.22 (95% confidence interval: -0.46, 0.......02; P = 0.07; I(2) = 68%). CONCLUSION: In the studies included in this review, more intense placebos were not consistently associated with larger effects than less intense placebos....

  19. Multilamellar structures and filament bundles are found on the cell surface during bunyavirus egress.

    Directory of Open Access Journals (Sweden)

    Laura Sanz-Sánchez

    Full Text Available Inside cells, viruses build specialized compartments for replication and morphogenesis. We observed that virus release associates with specific structures found on the surface of mammalian cells. Cultured adherent cells were infected with a bunyavirus and processed for oriented sectioning and transmission electron microscopy. Imaging of cell basal regions showed sophisticated multilamellar structures (MLS and extracellular filament bundles with attached viruses. Correlative light and electron microscopy confirmed that both MLS and filaments proliferated during the maximum egress of new viruses. MLS dimensions and structure were reminiscent of those reported for the nanostructures on gecko fingertips, which are responsible for the extraordinary attachment capacity of these lizards. As infected cells with MLS were more resistant to detachment than control cells, we propose an adhesive function for these structures, which would compensate for the loss of adherence during release of new virus progeny.

  20. Pyranoanthocyanin dimers: a new family of turquoise blue anthocyanin-derived pigments found in Port wine.

    Science.gov (United States)

    Oliveira, Joana; Azevedo, Joana; Silva, Artur M S; Teixeira, Natércia; Cruz, Luis; Mateus, Nuno; de Freitas, Victor

    2010-04-28

    In the present work, several compounds bearing similar spectroscopic features were found to occur in aged Port wines and respective sediments (lees). The data obtained revealed two new families of compounds with unique spectroscopic characteristics, displaying a wavelength of the maximum absorption at high wavelength in the visible spectrum at approximately 730 and approximately 680 nm. The structure of these pigments was elucidated by liquid chromatography/diode array detector-mass spectrometry (LC/DAD-MS) and nuclear magnetic resonance (NMR), and their formation pathway in wines was established. Their structure is constituted by two pyranoanthocyanin moieties linked together through a methyne bridge. This new family of compounds displays an attractive and rare turquoise blue color at acidic conditions and has never been reported in the literature.

  1. New Q lineage found in bovine (Bos taurus) of Iberian Peninsula.

    Science.gov (United States)

    Lopez-Oceja, Andres; Muro-Verde, Amara; Gamarra, David; Cardoso, Sergio; de Pancorbo, Marian M

    2016-09-01

    The northern Iberian Peninsula is home to a variety of autochthonous cattle breeds, such as the Terreña and Pirenaica. With the objective of characterizing the matrilineal lineages of these breeds, a study of mitochondrial DNA was performed. The D-loop of 155 individuals was analyzed and most of the individuals were carriers of the T3 haplogroup, while haplogroups T and T1 were much less frequent. A Pirenaica individual belonging to the Q haplogroup was found. To verify the presence of the Q haplogroup individual, the entire mitochondrial DNA was sequenced and compared with two descendants. The individuals were assigned to the Q1 sub-haplogroup. These findings extend the geographic distribution of the Q haplogroup to the south west of the European continent. This new Q1 lineage has seven polymorphisms in the coding region, so this lineage is probably as old as the Q lineages described to date.

  2. Lost and Found, Letters and Methods: Assessing Attitudes toward Chiropractic and Medical Care

    Directory of Open Access Journals (Sweden)

    Hannah Kern

    2010-10-01

    Full Text Available Attitudes toward traditional and chiropractic medicine were compared using Milgram's lost letter technique. A total of 192 letters were placed on the windshields of vehicles in parking lots at six restaurants and department stores in each of four quadrants of a medium-sized, Southeastern city. These letters were addressed to "Admissions" at either a fictitious Institute of Medicine or Institute of Chiropractic Care. Return addresses included either a male or a female name. Thus, those who found a lost letter were faced with the option of returning or not returning a letter from either a male or a female, addressed to an Institute of traditional or non-traditional medicine. After examining previous studies which had used the lost letter technique, numerous methodological improvements were implemented. For example, letters were randomly assigned to potential drop spots for each of 24 study locations (six study locations in each of four city quadrants, and a Latin square design was used to control for possible order effects in the four study conditions that were implemented. Nearly 65% of the letters (124 of 192 were returned. We found: 1 letters addressed to a fictitious Institute of Chiropractic Care were just as likely to be returned as those addressed to a fictitious Institute of Medicine; 2 letters with female return addresses were as likely to be returned as those with male return addresses; 3 there was no interaction between study conditions; 4 based on what was essentially a replication study, a comparison of the pattern of returns using the first and second cycle of lost letters (n = 96 for each cycle revealed an equivalent pattern of no-difference findings. DOI: 10.2458/azu_jmmss.v1i1.78

  3. Failing to Fix What is Found: Risk Accommodation in the Oil and Gas Industry.

    Science.gov (United States)

    Stackhouse, Madelynn R D; Stewart, Robert

    2017-01-01

    The present program of research synthesizes the findings from three studies in line with two goals. First, the present research explores how the oil and gas industry is performing at risk mitigation in terms of finding and fixing errors when they occur. Second, the present research explores what factors in the work environment relate to a risk-accommodating environment. Study 1 presents a descriptive evaluation of high-consequence incidents at 34 oil and gas companies over a 12-month period (N = 873), especially in terms of those companies' effectiveness at investigating and fixing errors. The analysis found that most investigations were fair in terms of quality (mean = 75.50%), with a smaller proportion that were weak (mean = 11.40%) or strong (mean = 13.24%). Furthermore, most companies took at least one corrective action for high-consequence incidents, but few of these corrective actions were confirmed as having been completed (mean = 13.77%). In fact, most corrective actions were secondary interim administrative controls (e.g., having a safety meeting) rather than fair or strong controls (e.g., training, engineering elimination). Study 2a found that several environmental factors explain the 56.41% variance in safety, including management's disengagement from safety concerns, finding and fixing errors, safety management system effectiveness, training, employee safety, procedures, and a production-over-safety culture. Qualitative results from Study 2b suggest that a compliance-based culture of adhering to liability concerns, out-group blame, and a production-over-safety orientation may all impede safety effectiveness. © 2016 Society for Risk Analysis.

  4. Eight previously unidentified mutations found in the OA1 ocular albinism gene

    Directory of Open Access Journals (Sweden)

    Dufier Jean-Louis

    2006-04-01

    Full Text Available Abstract Background Ocular albinism type 1 (OA1 is an X-linked ocular disorder characterized by a severe reduction in visual acuity, nystagmus, hypopigmentation of the retinal pigmented epithelium, foveal hypoplasia, macromelanosomes in pigmented skin and eye cells, and misrouting of the optical tracts. This disease is primarily caused by mutations in the OA1 gene. Methods The ophthalmologic phenotype of the patients and their family members was characterized. We screened for mutations in the OA1 gene by direct sequencing of the nine PCR-amplified exons, and for genomic deletions by PCR-amplification of large DNA fragments. Results We sequenced the nine exons of the OA1 gene in 72 individuals and found ten different mutations in seven unrelated families and three sporadic cases. The ten mutations include an amino acid substitution and a premature stop codon previously reported by our team, and eight previously unidentified mutations: three amino acid substitutions, a duplication, a deletion, an insertion and two splice-site mutations. The use of a novel Taq polymerase enabled us to amplify large genomic fragments covering the OA1 gene. and to detect very likely six distinct large deletions. Furthermore, we were able to confirm that there was no deletion in twenty one patients where no mutation had been found. Conclusion The identified mutations affect highly conserved amino acids, cause frameshifts or alternative splicing, thus affecting folding of the OA1 G protein coupled receptor, interactions of OA1 with its G protein and/or binding with its ligand.

  5. Characterization of Cement Particles Found in Peri-implantitis-Affected Human Biopsy Specimens.

    Science.gov (United States)

    Burbano, Maria; Wilson, Thomas G; Valderrama, Pilar; Blansett, Jonathan; Wadhwani, Chandur P K; Choudhary, Pankaj K; Rodriguez, Lucas C; Rodrigues, Danieli C

    2015-01-01

    Peri-implantitis is a disease characterized by soft tissue inflammation and continued loss of supporting bone, which can result in implant failure. Peri-implantitis is a multifactorial disease, and one of its triggering factors may be the presence of excess cement in the soft tissues surrounding an implant. This descriptive study evaluated the composition of foreign particles from 36 human biopsy specimens with 19 specimens selected for analysis. The biopsy specimens were obtained from soft tissues affected by peri-implantitis around cement-retained implant crowns and compared with the elemental composition of commercial luting cement. Nineteen biopsy specimens were chosen for the comparison, and five test cements (TempBond, Telio, Premier Implant Cement, Intermediate Restorative Material, and Relyx) were analyzed using scanning electron microscopy equipped with energy dispersive x-ray spectroscopy. This enabled the identification of the chemical composition of foreign particles embedded in the tissue specimens and the composition of the five cements. Statistical analysis was conducted using classification trees to pair the particles present in each specimen with the known cements. The particles in each biopsy specimen could be associated with one of the commercial cements with a level of probability ranging between .79 and 1. TempBond particles were found in one biopsy specimen, Telio particles in seven, Premier Implant Cement particles in four, Relyx particles in four, and Intermediate Restorative Material particles in three. Particles found in human soft tissue biopsy specimens around implants affected by peri-implant disease were associated with five commercially available dental cements.

  6. Electrochemical behaviour of brass in chloride solution concentrations found in eccrine fingerprint sweat

    Energy Technology Data Exchange (ETDEWEB)

    Bond, John W., E-mail: jwb13@le.ac.uk [Department of Chemistry, George Porter Building, University of Leicester, University Road, Leicester LE1 7RH (United Kingdom); Lieu, Elaine [Department of Physics and Astronomy, University of Leicester, University Road, Leicester LE1 7RH (United Kingdom)

    2014-09-15

    Highlights: • Corrosion of brass in NaCl concentrations found in eccrine sweat was investigated. • Concentrations < 0.2 M produce a layer of mainly zinc oxide after 24 h. • A concentration of 0.2 M enables active corrosion of brass at room temperature. • 0.2 M NaCl gives both zinc and copper dissolution. • 24-h immersion of brass in 0.2 M NaCl gives an oxide film thickness of 1.3 nm. - Abstract: In this work, the corrosion properties of α phase brass immersed in concentrations of aqueous NaCl solutions that are typically found in eccrine fingerprint sweat and range between 0.01 M and 0.2 M have been analysed. Analysis methods employed were electrochemical techniques, X-ray photoelectron spectroscopy and optical profiling. For NaCl concentrations <0.2 M, active corrosion did not occur although, after a period of 24 h, a passivating layer of mainly zinc oxide formed. At a concentration of 0.2 M active corrosion did occur, with measured corrosion potentials consistent with both brass and copper dissolution. A 1 h contact time at this concentration (0.2 M) resulted in the formation of a zinc oxide passivating layer with the surface ratio of zinc oxide to copper oxide increasing with time. Film thickness was calculated to be of the order of 1.3 nm after 24 h contact. Formation of oxide layers on brass by fingerprint sweat as observed here may well have implications for the successful investigation of crime by the visualisation of corrosion fingerprint ridge patterns or the reduction of hospital environmental contamination by hand contact with brass objects such as door handles or taps.

  7. Filthy lucre: A metagenomic pilot study of microbes found on circulating currency in New York City.

    Directory of Open Access Journals (Sweden)

    Julia M Maritz

    Full Text Available Paper currency by its very nature is frequently transferred from one person to another and represents an important medium for human contact with-and potential exchange of-microbes. In this pilot study, we swabbed circulating $1 bills obtained from a New York City bank in February (Winter and June (Summer 2013 and used shotgun metagenomic sequencing to profile the communities found on their surface. Using basic culture conditions, we also tested whether viable microbes could be recovered from bills.Shotgun metagenomics identified eukaryotes as the most abundant sequences on money, followed by bacteria, viruses and archaea. Eukaryotic assemblages were dominated by human, other metazoan and fungal taxa. The currency investigated harbored a diverse microbial population that was dominated by human skin and oral commensals, including Propionibacterium acnes, Staphylococcus epidermidis and Micrococcus luteus. Other taxa detected not associated with humans included Lactococcus lactis and Streptococcus thermophilus, microbes typically associated with dairy production and fermentation. Culturing results indicated that viable microbes can be isolated from paper currency.We conducted the first metagenomic characterization of the surface of paper money in the United States, establishing a baseline for microbes found on $1 bills circulating in New York City. Our results suggest that money amalgamates DNA from sources inhabiting the human microbiome, food, and other environmental inputs, some of which can be recovered as viable organisms. These monetary communities may be maintained through contact with human skin, and DNA obtained from money may provide a record of human behavior and health. Understanding these microbial profiles is especially relevant to public health as money could potentially mediate interpersonal transfer of microbes.

  8. Maternal Phylogeny of a Newly-Found Yak Population in China

    Directory of Open Access Journals (Sweden)

    Deqiang Zou

    2012-09-01

    Full Text Available The Jinchuan yak is a new yak population identified in Sichuan, China. This population has a special anatomical characteristic: an additional pair of ribs compared with other yak breeds. The genetic structure of this population is unknown. In the present study, we investigated the maternal phylogeny of this special yak population using the mitochondrial DNA variation. A total of 23 Jinchuan yaks were sequenced for a 823-bp fragment of D-loop control region and three individuals were sequenced for the whole mtDNA genome with a length of 16,371-bp. To compare with the data from other yaks, we extracted sequence data from Genebank, including D-loop of 398 yaks (from 12 breeds and 55 wild yaks, and whole mitochondrial genomes of 53 yaks (from 12 breeds and 21 wild yaks. A total of 127 haplotypes were defined, based on the D-loop data. Thirteen haplotypes were defined from 23 mtDNA D-loop sequences of Jinchuan yaks, six of which were shared only by Jinchuan, and one was shared by Jinchuan and wild yaks. The Jinquan yaks were found to carry clades A and B from lineage I and clade C of lineage II, respectively. It was also suggested that the Jinchuan population has no distinct different phylogenetic relationship in maternal inheritance with other breeds of yak. The highly haplotype diversity of the Pali breed, Jinchuan population, Maiwa breed and Jiulong breed suggested that the yak was first domesticated from wild yaks in the middle Himalayan region and the northern Hengduan Mountains. The special anatomic characteristic that we found in the Jinchuan population needs further studies based on nuclear data.

  9. Incidental splenic nodules found on MR imaging done for assessment of iron overload in children.

    Science.gov (United States)

    Ahyad, Rayan A; Lam, Christopher Z; Shearkhani, Omid; Navarro, Oscar M

    2017-06-01

    MR imaging is used to assess iron overload in patients with hemoglobinopathies and in those who have undergone multiple blood transfusions. Sometimes splenic nodules are found incidentally on these examinations and this may cause diagnostic uncertainty. To determine the prevalence, imaging characteristics and evolution of splenic nodules found on MR imaging for iron overload evaluation. Retrospective review of all MR imaging examinations performed for iron overload assessment from 2005 to 2015 in a tertiary pediatric hospital. The presence of focal splenic nodules including number, size, signal characteristics and changes on follow-up MR imaging were recorded. Relevant patient clinical information including underlying hematological disease was also documented. A total of 318 patients had MR imaging for iron overload assessment. Of these, 25 (8%) had at least one incidental splenic nodule. Sickle cell disease was present in 22 patients (88%) and thalassemia in 3 (12%). On intermediate-weighted spin-echo images, the nodules had high signal intensity compared to the remainder of the spleen in 23 patients (92%) and low signal intensity in the remaining 2 (8%). In all patients (100%) the nodules showed progressive loss of signal intensity with increasing echo time values. Follow-up MR imaging was performed in 20 (80%) patients, which showed an increase in the size of the splenic nodules in 7 patients (35%) stability in 11 (55%) and a decrease in size in 2 (10%). It is not uncommon to find splenic nodules during MR evaluation of iron overload. In patients with sickle cell disease, most of these nodules are thought to represent preserved splenic tissue and appear hyperintense compared to the remainder of the spleen. They frequently remain stable on follow-up imaging, although about a third of them may show growth. Awareness of these nodules is important to avoid concern for potential malignancy and unnecessary investigations.

  10. Incidental splenic nodules found on MR imaging done for assessment of iron overload in children

    Energy Technology Data Exchange (ETDEWEB)

    Ahyad, Rayan A.; Lam, Christopher Z.; Navarro, Oscar M. [University of Toronto, Department of Medical Imaging, Toronto, ON (Canada); The Hospital for Sick Children, Department of Diagnostic Imaging, Toronto, ON (Canada); Shearkhani, Omid [The Hospital for Sick Children, Department of Diagnostic Imaging, Toronto, ON (Canada)

    2017-06-15

    MR imaging is used to assess iron overload in patients with hemoglobinopathies and in those who have undergone multiple blood transfusions. Sometimes splenic nodules are found incidentally on these examinations and this may cause diagnostic uncertainty. To determine the prevalence, imaging characteristics and evolution of splenic nodules found on MR imaging for iron overload evaluation. Retrospective review of all MR imaging examinations performed for iron overload assessment from 2005 to 2015 in a tertiary pediatric hospital. The presence of focal splenic nodules including number, size, signal characteristics and changes on follow-up MR imaging were recorded. Relevant patient clinical information including underlying hematological disease was also documented. A total of 318 patients had MR imaging for iron overload assessment. Of these, 25 (8%) had at least one incidental splenic nodule. Sickle cell disease was present in 22 patients (88%) and thalassemia in 3 (12%). On intermediate-weighted spin-echo images, the nodules had high signal intensity compared to the remainder of the spleen in 23 patients (92%) and low signal intensity in the remaining 2 (8%). In all patients (100%) the nodules showed progressive loss of signal intensity with increasing echo time values. Follow-up MR imaging was performed in 20 (80%) patients, which showed an increase in the size of the splenic nodules in 7 patients (35%) stability in 11 (55%) and a decrease in size in 2 (10%). It is not uncommon to find splenic nodules during MR evaluation of iron overload. In patients with sickle cell disease, most of these nodules are thought to represent preserved splenic tissue and appear hyperintense compared to the remainder of the spleen. They frequently remain stable on follow-up imaging, although about a third of them may show growth. Awareness of these nodules is important to avoid concern for potential malignancy and unnecessary investigations. (orig.)

  11. Biotechnological Production of Inducible Defense-Related Proteins in Edible Radish (Raphanus Sativus) Found in Nepal

    Science.gov (United States)

    Khanal, Praval; Karmacharya, Anil; Sharma, Shishir; Nepal, Ashwini K.; Shrestha, Kanti

    2014-01-01

    Background: Fungal infection in plant leads to use of many hazardous antifungal chemicals. Alternative to these chemicals, defense related antifungal proteins can be used in case of fungal diseases. Aims: An experiment was done in two varieties of edible radish (Raphanus sativus var. Pyuthane Raato and Raphanus sativus var. all season) with aims to produce defense protein within the plant, to identify and perform molecular characterization of those antifungal proteins. The next aim was to compare the antifungal property of those proteins with commercially available synthetic pesticides. Methods: Both varieties of radish were infected with fungi (Alternaria alternata and Fusarium oxysporum). Protein samples were isolated from leaves following the standard protocol as described for β-glucuronidase (GUS) assay and were run along with the standard protein marker of 10-250kDa in sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) to identify and molecularly characterize them. Results: An additional band in the range of 37-50kDa was observed in the fungal infected samples, which was not seen on uninfected samples. The antifungal assay was carried out for every sample in 96 wells microtitre plate. The extracted protein samples from fungal inoculated plants showed the significant inhibition of fungal growth compared to other samples. On the basis of molecular weight and their antifungal properties, the protein samples from the fungal infected plant were found to be PR2 (Glucanase) and PR3 (Chitinase). Conclusion: Defense related proteins were successfully produced in two varieties of radish found in Nepal. The use of such biologically produced proteins may reduce the use of biologically harmful synthetic pesticides. PMID:24596739

  12. Acupuncture points & use of moxibustion, found in the popular literature & paintings of 17th century Japan.

    Science.gov (United States)

    Omura, Y

    1984-01-01

    Acupuncture and moxibustion have long been an integral part of Far Eastern oriental medicine. Moxibustion and acupuncture cannot be discussed without each other since both use the same acupuncture point locations and nomenclatures. In the late 17th century, the famous travel diary of Basho, a Japanese master of haiku poetry, made reference to personal use of moxibustion on one of the well-known acupuncture points, stomach 36. Recently, the author found 2 paintings of a 17th century Kyoto geisha house and its surroundings in the Boston Museum of Fine Arts, painted in realistic color by Moronobu, the originator of the Ukiyoe style and a contemporary of Basho. Part of the scene depicts some professional porters at work; on their legs are white scars at some of the well-known acupuncture points, including stomach 36 and spleen 6. The scars appear to be the result of moxibustion. This may indicate the common use of moxibustion on well-known acupuncture points of the lower extremities in late 17th century Japan for professional porters and for people making extensive journeys. Further support of the relatively widespread use of acupuncture and moxibustion is even found in the popular, non-medical literature of late 17th century Japan. In one of the short stories about the life of average people, written by the novelist Saikaku, the details of a young woman giving moxibustion on the back of a young man is realistically described with illustrations. Reports written by some of the foreign physicians who visited Japan during this period were published, describing these methods with illustrations.(ABSTRACT TRUNCATED AT 250 WORDS)

  13. CRISTISPIRA IN NORTH AMERICAN SHELLFISH. A NOTE ON A SPIRILLUM FOUND IN OYSTERS

    Science.gov (United States)

    Noguchi, Hideyo

    1921-01-01

    Ten varieties of North American shellfish were examined for the occurrence of Cristispira in their styles. A cristispira was found in various numbers in Ostrea virginiana, Venus mercenaria, and Modiola modiolus, but none in Ensis americana, Mya arenaria, Mactra solidissima, Pecten irradians, Mytilus edulis, Fulgur canaliculatus, or Nassa obsoleta. Of 298 oysters, only 128 showed the crystalline styles, in which cristispiras were present in 99. Active cristispiras were found in 59 styles only and degenerated forms in the remaining 40. In 110 clams (Venus mercenaria) 70 styles were found, and only 8 of these contained cristispiras; 5 yielded active and the other 3 degenerated cristispiras. In 97 modiolas there were 73 styles, only 4 of which contained cristispiras. The physical properties of the crystalline styles of these shellfish varied considerably. The styles of the oysters were moderately soft, and when exposed to the air or mixed with sea water they underwent liquefaction, forming a clear, viscid material. The styles from clams and modiolas were opaque and were more firm, not easily crushed even in a mortar. The styles of the scallops were the most solid of all the styles examined. It happened that the softer the styles, the more frequent was the occurrence of the cristispira; in fact, no cristispira was detected in styles other than those of oysters, clams, and modiolas, of which oysters had the softest styles and the largest percentage of cristispira invasion. The following observations were made regarding the structure of the cristispira found in oysters. The body is a long, flexible cylinder, with blunt extremities, towards which the diameter gradually diminishes. In motion the body rapidly stretches and contracts, forming in the contracted state several serpentine undulations. A membranous appendage (Gross' crista) winds about the body throughout its entire length. The inner margin is in connection with the body, the outer margin is free and is distinctly

  14. CRISTISPIRA IN NORTH AMERICAN SHELLFISH. A NOTE ON A SPIRILLUM FOUND IN OYSTERS.

    Science.gov (United States)

    Noguchi, H

    1921-08-31

    Ten varieties of North American shellfish were examined for the occurrence of Cristispira in their styles. A cristispira was found in various numbers in Ostrea virginiana, Venus mercenaria, and Modiola modiolus, but none in Ensis americana, Mya arenaria, Mactra solidissima, Pecten irradians, Mytilus edulis, Fulgur canaliculatus, or Nassa obsoleta. Of 298 oysters, only 128 showed the crystalline styles, in which cristispiras were present in 99. Active cristispiras were found in 59 styles only and degenerated forms in the remaining 40. In 110 clams (Venus mercenaria) 70 styles were found, and only 8 of these contained cristispiras; 5 yielded active and the other 3 degenerated cristispiras. In 97 modiolas there were 73 styles, only 4 of which contained cristispiras. The physical properties of the crystalline styles of these shellfish varied considerably. The styles of the oysters were moderately soft, and when exposed to the air or mixed with sea water they underwent liquefaction, forming a clear, viscid material. The styles from clams and modiolas were opaque and were more firm, not easily crushed even in a mortar. The styles of the scallops were the most solid of all the styles examined. It happened that the softer the styles, the more frequent was the occurrence of the cristispira; in fact, no cristispira was detected in styles other than those of oysters, clams, and modiolas, of which oysters had the softest styles and the largest percentage of cristispira invasion. The following observations were made regarding the structure of the cristispira found in oysters. The body is a long, flexible cylinder, with blunt extremities, towards which the diameter gradually diminishes. In motion the body rapidly stretches and contracts, forming in the contracted state several serpentine undulations. A membranous appendage (Gross' crista) winds about the body throughout its entire length. The inner margin is in connection with the body, the outer margin is free and is distinctly

  15. SOURCE AND PATHWAY DETERMINATION FOR BERYLLIUM FOUND IN BECHTEL NEVADA NORTH LAS VEGAS FACILITIES

    Energy Technology Data Exchange (ETDEWEB)

    BECHTEL NEVADA

    2004-07-01

    In response to the report ''Investigation of Beryllium Exposure Cases Discovered at the North Las Vegas Facility of the National Nuclear Security Administration'', published by the U.S. Department of Energy (DOE), National Nuclear Security Administration (NNSA) in August 2003, Bechtel Nevada (BN) President and General Manager Dr. F. A. Tarantino appointed the Beryllium Investigation & Assessment Team (BIAT) to identify both the source and pathway for the beryllium found in the North Las Vegas (NLV) B-Complex. From September 8 to December 18, 2003, the BIAT investigated the pathway for beryllium and determined that a number of locations existed at the Nevada Test Site (NTS) which could have contained sufficient quantities of beryllium to result in contamination if transported. Operations performed in the B-1 Building as a result of characterization activities at the Engine Maintenance, Assembly, and Disassembly (EMAD); Reactor Maintenance, Assembly, and Disassembly (RMAD); Test Cells A and C; and the Central Support Facility in Area 25 had the greatest opportunity for transport of beryllium. Investigative monitoring and sampling was performed at these sites with subsequent transport of sample materials, equipment, and personnel from the NTS to the B-1 Building. The timeline established by the BIAT for potential transport of the beryllium contamination into the B-1 Building was from September 1997 through November 2002. Based on results of recently completed swipe sampling, no evidence of transport of beryllium from test areas has been confirmed. Results less than the DOE beryllium action level of 0.2 ???g/100 cm2 were noted for work support facilities located in Area 25. All of the identified sites in Area 25 worked within the B-1 tenant's residency timeline have been remediated. Legacy contaminants have either been disposed of or capped with clean borrow material. As such, no current opportunity exists for release or spread of beryllium

  16. [Development of orthopedics and founding of the Clinic for Orthopedic Surgery and Traumatology in Novi Sad].

    Science.gov (United States)

    Mikić, Z

    1998-01-01

    A study of the development of the orthopaedic surgery in Novi Sad from the antique times till 1980 when the Clinic for Orthopaedic. Surgery and Traumatology was established has been carried out. Development from Roman Times till the Second World War. The first material evidence of the surgical activities in this area originates from the epoch of the Roman Empire, when under the emperor Augustus (Augustus, 27 B.C.-14 A.D.), the northern border of the Empire was established and fortified on the river Danube. At that time on the place of the contemporary Petrovaradin Fortress, a small fortification with a permanent garrison, called Cusum, was built. As it was proved by excavation of the surgical instruments from the Roman time at the nearby Sremska Mitrovica (Sirmium) the surgery in the Roman legions was quite developed and it could be concluded that some forms of surgery and orthopaedics were practised in the antique Cusum as well. There is no reliable evidence about the health service in the area after the Roman era till the 1689 when Petrovaradin was finally sized by Austrian troops from the Turks, and when the first recorded hospital (Petrovaradin Military Hospital) in this region was founded. At that time on the northern shore of the river Danube a new settlement, developing later into the town of Novi Sad, was established. Surgery together with orthopaedics at that time were performed by the so-called "feldschers", and then by primitive, self-taught surgeons who were actually experienced barbers, while educated doctors started to practice surgery only in the 19th century when the first surgical department in Novi Sad was founded in the Great Town Hospital, and for years after that, the orthopaedics was practised by general surgeons. The foundation of the Anglo-Yugoslav Children's Hospital for Tuberculosis of the Bones and Joints at Sremska Kamenica in 1934 by Dr. Katherine S. Macphail, a great benefactress of our people, was of great importance for the

  17. Let me sing your songs: how Finns found xöömei

    Directory of Open Access Journals (Sweden)

    Sauli Heikkilä

    2017-06-01

    Full Text Available The author of this essay, musician and founder of the Throat Singing Association of Finland (1997, tells the story of how an association of throat singing practitioners came to be in Finland, and how to teach this art to those wishing to learn it. The story also covers the author’s own musical preferences and his life-changing visit to a week-long workshop led by Boris Salchak from Tuva in 1995. Two years later, the author and other aficionados of Tuvan xöömei founded the Throat Singing Association and started holding festivals featuring invited Tuvan singers and throat singing courses. The author describes his collaboration with renowned Tuvan performers, as well as throat singing scholars from the USA, the Netherlands, UK, Italy, etc. The author holds that throat (or overtone singing is a special sound practice. Tuvan practices can be compared with similar techniques developed by indigenous peoples of Africa, North America, Japan and Tibet. Throat singing as a practice is closely linked to specific ancient worldviews of peoples and cultures living close to nature. Finns are also considered living in close proximity to nature, which may explain their partiality to throat signing. Dozens actively practice xöömei and hundreds have experienced it, which is a much larger percentage than in other European states. In the essay, the author also focuses on the throat singing courses he has been giving for a while and shares his observations of his students, their motivation, specific training techniques and adapting them to the desires and intentions of his students. He believes that almost everybody can learn singing, and most people can have a command of throat singing. The essay also covers the main problems that aspiring throat singers can face, as well as specific styles of the xöömei, concluding with the idea that it is impossible to master throat singing in a short period of time. The key to success is only found in regular and extensive

  18. A systematic review found no consistent difference in effect between more and less intensive placebo interventions.

    Science.gov (United States)

    Fässler, Margrit; Meissner, Karin; Kleijnen, Jos; Hróbjartsson, Asbjørn; Linde, Klaus

    2015-04-01

    It has been suggested that some placebo interventions might be associated with larger clinical effects than others. In a systematic review, we investigated whether there is evidence from direct comparisons in randomized clinical trials including two or more placebo groups supporting this hypothesis. Eligible trials were identified through electronic database searches and citation tracking up to February 2013. Placebo interventions in a trial were categorized into a more intense and a less intense intervention based on complexity, invasiveness, or route of administration and time needed for application. Twelve studies with 1,059 patients receiving placebo met the eligibility criteria. Studies were highly heterogeneous regarding patients, interventions, outcomes, and risk of bias. Seven studies did not find any significant differences between the more intense and the less intense placebo intervention, four studies found differences for single outcomes, and one study consistently reported significantly larger effects of the more intense placebo. An explorative meta-analysis yielded a standardized mean difference -0.22 (95% confidence interval: -0.46, 0.02; P = 0.07; I(2) = 68%). In the studies included in this review, more intense placebos were not consistently associated with larger effects than less intense placebos. Copyright © 2015 Elsevier Inc. All rights reserved.

  19. Death of embryos from 2300-year-old quinoa seeds found in an archaeological site.

    Science.gov (United States)

    Burrieza, Hernán Pablo; Sanguinetti, Agustín; Michieli, Catalina Teresa; Bertero, Héctor Daniel; Maldonado, Sara

    2016-12-01

    In the 1970s, during excavations at Los Morrillos, San Juan, Argentina, quinoa seeds were found within ancient pumpkin crocks protected from the light and high temperatures, and preserved in the very dry conditions of the region. The radiocarbon dates confirmed the age of these seeds at around 2300 years. Sectioning of some of these seeds showed reddish-brown embryos, different from the white embryos of recently harvested quinoa seeds. The ancient seeds did not germinate. The structure of the embryo cells was examined using light and transmission electron microscopy; proteins were analyzed by electrophoresis followed by Coomassie blue and periodic acid Schiff staining and fatty acids by gas chromatography. The state of nuclear DNA was investigated by TUNEL assay, DAPI staining, ladder agarose electrophoresis and flow cytometry. Results suggest that, although the embryo tissues contained very low water content, death occurred by a cell death program in which heterochromatin density was dramatically reduced, total DNA was degraded into small fragments of less than 500bp, and some proteins were modified by non-enzymatic glycation, generating Maillard products. Polyunsaturated fatty acids decreased and became fragmented, which could be attributable to the extensive oxidation of the most sensitive species (linolenic and linoleic acids) and associated with a collapse of lipid bodies. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  20. A Novel Inhibitor of Mammalian Triosephosphate Isomerase Found by an In Silico Approach

    Directory of Open Access Journals (Sweden)

    Lorraine Marsh

    2014-01-01

    Full Text Available Triosephosphate isomerase (TIM is an essential, highly conserved component of glycolysis. Tumors are often dependent on glycolysis for energy and metabolite production (the Warburg effect. Glycolysis inhibitors thus show promise as cancer treatments. TIM inhibition, unlike inhibition of other glycolysis enzymes, also produces toxic methylglyoxal targeted to regions of high glycolysis, an effect that might also be therapeutically useful. Thus TIM is an attractive drug target. A total of 338,562 lead-like molecules were analyzed computationally to find TIM inhibitors by an efficient “double screen” approach. The first fragment-sized compounds were studied using structure-based virtual screening to identify binding motifs for mammalian TIM. Subsequently, larger compounds, filtered to meet the binding criteria developed in the first analysis, were ranked using a second round of structure-based virtual screening. A compound was found that inhibited mammalian TIM in vitro in the micromolar range. Docking and molecular dynamics (MD suggested that the inhibitor made hydrogen bond contacts with TIM catalytic residues. In addition, hydrophobic contacts were made throughout the binding site. All predicted inhibitor-TIM interactions involved TIM residues that were highly conserved. The discovered compound may provide a scaffold for elaboration of other inhibitors.

  1. Serum amyloid A is found on ApoB-containing lipoproteins in obese humans with diabetes.

    Science.gov (United States)

    Jahangiri, Anisa; Wilson, Patricia G; Hou, Tianfei; Brown, Aparna; King, Victoria L; Tannock, Lisa R

    2013-05-01

    In murine models of obesity/diabetes, there is an increase in plasma serum amyloid A (SAA) levels along with redistribution of SAA from high-density lipoprotein (HDL) to apolipoprotein B (apoB)-containing lipoprotein particles, namely, low-density lipoprotein and very low-density lipoprotein. The goal of this study was to determine if obesity is associated with similar SAA lipoprotein redistribution in humans. Three groups of obese individuals were recruited from a weight loss clinic: healthy obese (n = 14), metabolic syndrome (MetS) obese (n = 8), and obese with type 2 diabetes (n = 6). Plasma was separated into lipoprotein fractions by fast protein liquid chromatography, and SAA was measured in lipid fractions using enzyme-linked immunosorbent assay and Western blotting. Only the obese diabetic group had SAA detectable in apoB-containing lipoproteins, and SAA reverted back to HDL with active weight loss. In human subjects, SAA is found in apoB-containing lipoprotein particles only in obese subjects with type 2 diabetes, but not in healthy obese or obese subjects with MetS. Copyright © 2012 The Obesity Society.

  2. Main Isoflavones Found in Dietary Sources as Natural Anti-inflammatory Agents.

    Science.gov (United States)

    Danciu, Corina; Avram, Stefana; Pavel, Ioana; Ghiulai, Roxana; Dehelean, Cristina; Ersilia, Alexa; Minda, Daliana; Petrescu, Cristina; Moaca, Elena; Soica, Codruta

    2017-11-09

    Isoflavones are natural compounds belonging to the class of isoflavonoids, molecules with a chemical structure based on the 3-phenyl chromen-4-one backbone. As a particular element, the isoflavones are called also phytoestrogens, due to the structural similarity with 17-β estradiol, the primary female sex hormone, presenting both estrogen-agonist and estrogen-antagonist properties. This class of secondary plant metabolites has been extensively reported in the literature for a wide range of therapeutic activities including antioxidant, chemopreventive, anti-inflammatory, anti-allergic, antibacterial, cardio preventive effects. To sum up the latest information regarding the main isoflavones found in dietary sources as natural anti-inflammatory agents. The review updates with the recent research about genistein, daidzein, glycitein, biochanin A, formononetin and equol as anti-inflammatory phytocompounds. As a particular element the implications of this isoflavones in the link between inflammation and angiogenesis is also discussed. The review concludes that the main isoflavones in dietary sources present in vitro and/or in vivo anti inflammatory potential by activating various biochemical and molecular mechanisms. The depicted findings translated into practical aspects strength the idea that the isoflavones genistein, daidzein, glycitein, biochanin A, formononetin and equol can be used in various inflammation based diseases as an alternative source for classical medication and that consummation of foods rich in isoflavones may represent prerequisite used in order to prevent respectively to decrease the evolution of inflammation based diseases. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  3. Further analysis of remnants found in LDEF and Mir impact craters

    Science.gov (United States)

    Berthoud, S. Lucinda; Mandeville, J. C.

    1994-01-01

    This study is the further investigation of space-exposed samples recently recovered from the American satellite LDEF and the Franco-Soviet Mir 'Aragatz' experiment. Some interesting impact features have been selected as examples to demonstrate various findings. Part of the objective of the experiments was to determine the nature and origin of particles in low earth orbit (LEO). Observations show that the 'multiple foil detectors' appear to be an effective way of retaining impactor residues of larger particles. They provide a 'witness' foil that shows the shape and dimensions of the impacting particle. Several low-velocity (less than 4 km/s) oblique craters containing significant quantities of impactor residue have been identified. Energy dispersive spectrometer (EDS) analyses of the residues show evidence of micrometeoroid and debris compositions. Similarities between the meteoroid signatures and those of Brownlee particles have been noted. Evidence of at least two different grain compositions in one impacting particle is shown. The discovery of debris impacts on the trailing edge of LDEF demonstrates that artificial debris may be found, not just in circular orbits, but also in elliptical orbits.

  4. Genetic Diversity Study Among Six Genera of Amaranth Family Found in Malang Based on RAPD Marker

    Directory of Open Access Journals (Sweden)

    Arik Arubil Fatinah

    2012-12-01

    Full Text Available Genera of amaranth family tend to have phenotypic variation partly caused by environmental factor. Phenotypic variation was the result of interaction between genetic and environmental factors. One of molecular markers that is widely used for detecting genetic variation is RAPD. RAPD is used for polymorphism detections and is now possible for identifiying a large number of loci and ascribes unambiguous taxonomic and genetic relationships among different taxa. Members of amaranth family found in Indonesia are Amaranthus, Celosia, Aerva, Alternanthera, Achyranthes, Gomphrena, Salsola, and Iresine. Six genera of which (Amaranthus, Celosia, Aerva, Alternanthera, Achyranthes, and Gomphrena were observed in this study. DNA was extracted from fresh young leaves using Doyle and Doyle’s method with modification in the extraction buffer used. RAPD analyses were carried out with 20 decamer primers from Kit A of Operon Technology. DNA was amplified using master cycler gradient Eppendorf with 35 cycles. RAPD products were separated on 1,5 % agarose gels and detected by staining with ethidium bromide. There were 374 bands generated in 18 random primers. The number of monomorphic bands, polymorphic bands, and the percentage of polymorphism were 21 bands, 353 bands, and 94,38 % respectively. The high number and percentage of polymorphic bands revealed genomic DNA variation. This variation is in accordance with phenotypic variation detected in this experiment. Therefore, it can be concluded that, based on DNA polymorphism detected by RAPD, Amaranth family can be classified into two sub families namely Amaranthoideae and Gomphrenoideae.

  5. Characterization of Peptides Found in Unprocessed and Extruded Amaranth (Amaranthus hypochondriacus) Pepsin/Pancreatin Hydrolysates

    Science.gov (United States)

    Montoya-Rodríguez, Alvaro; Milán-Carrillo, Jorge; Reyes-Moreno, Cuauhtémoc; González de Mejía, Elvira

    2015-01-01

    The objectives of this study were to characterize peptides found in unprocessed amaranth hydrolysates (UAH) and extruded amaranth hydrolysates (EAH) and to determine the effect of the hydrolysis time on the profile of peptides produced. Amaranth grain was extruded in a single screw extruder at 125 °C of extrusion temperature and 130 rpm of screw speed. Unprocessed and extruded amaranth flour were hydrolyzed with pepsin/pancreatin enzymes following a kinetic at 10, 25, 60, 90, 120 and 180 min for each enzyme. After 180 min of pepsin hydrolysis, aliquots were taken at each time during pancreatin hydrolysis to characterize the hydrolysates by MALDI-TOF/MS-MS. Molecular masses (MM) (527, 567, 802, 984, 1295, 1545, 2034 and 2064 Da) of peptides appeared consistently during hydrolysis, showing high intensity at 10 min (2064 Da), 120 min (802 Da) and 180 min (567 Da) in UAH. EAH showed high intensity at 10 min (2034 Da) and 120 min (984, 1295 and 1545 Da). Extrusion produced more peptides with MM lower than 1000 Da immediately after 10 min of hydrolysis. Hydrolysis time impacted on the peptide profile, as longer the time lower the MM in both amaranth hydrolysates. Sequences obtained were analyzed for their biological activity at BIOPEP, showing important inhibitory activities related to chronic diseases. These peptides could be used as a food ingredient/supplement in a healthy diet to prevent the risk to develop chronic diseases. PMID:25894223

  6. Challenges Found When Patterning Semiconducting Polymers with Electric Fields for Organic Solar Cell Applications

    Directory of Open Access Journals (Sweden)

    Fernando A. de Castro

    2012-01-01

    Full Text Available A material-independent, contactless structuring method of semiconducting organic materials for the fabrication of interface-enhanced bilayer solar cells is not available so far. Patterning of thin films using electrohydrodynamic instabilities possesses many desired characteristics and has convincingly been used as a simple method to structure and replicate patterns of nonconducting polymers on submicrometer length scales. However, the applicability of this technique to a wider range of materials has not been demonstrated yet. Here, we report attempts to structure poly(p-phenylene vinylene in a similar way. We found that thin films of poly(2-methoxy-5-(2′-ethylhexyl-oxy-1,4-phenylene-vinylene (MEH-PPV and poly(2-methoxy-5-(3′,7′-dimethyloctyloxy-1,4-phenylene-vinylene (MDMO-PPV could not be destabilized at all in the limited accessible range of the experimental parameters set by the delicate chemical nature of these materials. We discuss failure origins and present possible loopholes for the patterning of semiconducting polymers using electric fields.

  7. From Founding Father to Pious Son: Filiation, Language, and Royal Inheritance in Alfonso X, the Learned

    Directory of Open Access Journals (Sweden)

    Ryan Szpiech

    2015-07-01

    Full Text Available The influence of King Alfonso X of Castile (reg. 1252–1284 has been so wide that modern historians have stressed Alfonso’s foundational role as a ‘father’ of many Castilian cultural institutions and areas of writing, including prose literature, science, the legal code, and vernacular historiography. This paper argues that the modern focus on Alfonso’s foundational, ‘fatherly’ role, while logical in the context of modern literary historiography, is at odds with Alfonso’s own medieval view of himself as a ‘son’ and heir, one who inherited rather than founded cultural institutions. It proposes that a reorientation of Alfonsine studies according to this medieval worldview, one focused less on Alfonso’s innovations and foundations and more on his continuty with and dependance on his forebears, will permit a clearer portrayal of Alfonso’s importance in medieval literary history. To this end, it explores Aflonso’s representation of himself as the ‘son’ of his father, King Fernando III, in the prologues to his scientific translations, in his encomium of his father known as the Setenario, and in song 292 of his Cantigas de Santa María. A reading of these examples is offered as a first step towards the study of filiation and ‘sonship’ in the vast Alfonsine historiographical and legal corpuses.

  8. Phytochemical, Antioxidant and Anticancer Activities of Extracts of Seven Fruits Found in the Southern Brazilian Flora.

    Science.gov (United States)

    Bagattoli, P C D; Cipriani, D C; Mariano, L N B; Correa, M; Wagner, T M; Noldin, V F; Filho, V Cechinel; Niero, R

    2016-01-01

    Methanol extracts of seven edible fruits found in southern Brazil: Garcinia achachairu, Rubus imperialis, Rubus rosaefolius, Solanum quitoense, Solanum sessiliflorun, Diospyros inconstans and Plinia glomerata, were evaluated for their total phenol content and antioxidant activity in different in vitro free radical scavenging models. In addition, studies were performed on cell viability of extracts of the seeds of G. achachairu against murine melanoma cells. The fruits peel and seeds of G. achachairu were very promising in terms of total phenol content (data in gallic acid equivalent per gram), as assessed by the Folin-Ciocalteu method, with values of 9.70±3.2 and 8.40±1.1, respectively. On the other hand, antioxidant activity using the 2,2-diphenyl-1-picrylhydrazyl scavenging assay showed that the fruit pulp and peel of P. glomerata presented the best profile, with values of the 16.3±1.8 and 15.9±2.4 μg/ml, respectively. Regarding the cytotoxic effect of methanol extract and guttiferone A from G. achachairu, we have observed that both inhibit the growth of B16F10 tumor cells, with calculated IC50 values of 49.6±2.1 mg/ml and 48.6±5.4 mM, respectively.

  9. POSTMORTEM FINDINGS IN CETACEANS FOUND STRANDED IN THE PELAGOS SANCTUARY, ITALY, 2007-14.

    Science.gov (United States)

    Giorda, Federica; Ballardini, Marco; Di Guardo, Giovanni; Pintore, Maria Domenica; Grattarola, Carla; Iulini, Barbara; Mignone, Walter; Goria, Maria; Serracca, Laura; Varello, Katia; Dondo, Alessandro; Acutis, Pier Luigi; Garibaldi, Fulvio; Scaglione, Frine Eleonora; Gustinelli, Andrea; Mazzariol, Sandro; Di Francesco, Cristina Esmeralda; Tittarelli, Cristiana; Casalone, Cristina; Pautasso, Alessandra

    2017-10-01

    Between 2007 and 2014, 83 cetaceans were found stranded along the Ligurian coast of Italy, in the Pelagos Sanctuary, the largest marine protected area in the Mediterranean basin. Forty-nine (59%) were submitted to complete or partial necropsy, depending on the conservation status of the carcass. Based on gross and histological pathology and ancillary testing, the cause of death was determined and categorized as anthropogenic or natural (i.e., nonanthropogenic) in origin for 33 animals (67%) and of undetermined origin in the remaining 16 (33%). Natural causes of death, accompanied by either poor or good nutritional status, were attributed to 29 animals (59%), whereas four (8%) were diagnosed with an anthropogenic cause of death, consisting of interaction with fishing activities. Infectious and noninfectious disease was the most common cause of death, involving 29 cetaceans (59%). These data are valuable for understanding health and mortality trends in cetacean populations and can provide information for establishing policies for cetacean conservation and management in such an important protected area of the Mediterranean basin.

  10. Implementations of Riga city water supply system founded on groundwater sources

    Science.gov (United States)

    Lāce, I.; Krauklis, K.; Spalviņš, A.; Laicāns, J.

    2017-10-01

    Drinking water for Riga city is provided by the groundwater well field complex “Baltezers, Zakumuiza, Rembergi” and by the Daugava river as a surface water source. Presently (2016), the both sources jointly supply 122 thous.metre3day-1 of drinking water. It seems reasonable to use in future only groundwater, because river water is of low quality and its treatment is expensive. The research on this possibility was done by scientists of Riga Technical university as the task drawn up by the company “Aqua-Brambis”. It was required to evaluate several scenario of the groundwater supply for Riga city. By means of hydrogeological modelling, it was found out that groundwater well fields could provide 120-122 thous.metre3day-1 of drinking water for the Riga city and it is possible further not to use water of the Daugava river. However, in order to provide more extensive use of groundwater sources, existing water distribution network shall be adapted to the change of the water sources and supply directions within the network. Safety of water supply shall be ensured. The publication may be of interest for specialists dealing with problems of water supply for large towns.

  11. Islamic founding principles on organ transplantation and the evolution of Islamic scholarly opinions on the subject.

    Science.gov (United States)

    Kuddus, R H

    2014-01-01

    Muslims constitute about one-fourth of the human population, and a significant fraction of the organ recipients identify themselves as Muslims. A large fraction of the Muslim population is devout but unclear regarding the religious principles on organ donation and transplantation and is dependent on scholars' and imams' opinions. The Qur'an, the authentic Prophetic Traditions, and expert opinions on the subject were investigated. The sources of the Islamic founding principles on organ donation and transplantation are the Qur'an, the Prophetic Traditions, Usulul Fiqh or expert opinions based on the Qur'an and Traditions, and Maslaha or the principles of public interest deduced by the scholars. Some Muslim scholars, mostly from the Indian subcontinent, opine that live organ donation, extraction of organs from dead persons, and transplantation are prohibited. Many Arab scholars and Muslim scholars settled in the western hemisphere opine that live organ donation, organ extraction from dead persons, and transplantation are permitted, but organ donation must be a voluntary act of charity. Of late, the Iranian imams/scholars have recognized that the national government may acquire live donor organs for a uniform compensation and equitably distribute the acquired organs to patients with failing organs. The current Islamic working principles on transplantation medicine are nonuniform, transitory, and somewhat detached from the bulk of the population. How such heterogeneity is affecting transplantation medicine, and organ donation in particular, among Muslim populations warrants further investigation. Copyright © 2014 Elsevier Inc. All rights reserved.

  12. Anticancer Role of PPARγ Agonists in Hematological Malignancies Found in the Vasculature, Marrow, and Eyes

    Directory of Open Access Journals (Sweden)

    P. J. Simpson-Haidaris

    2010-01-01

    Full Text Available The use of targeted cancer therapies in combination with conventional chemotherapeutic agents and/or radiation treatment has increased overall survival of cancer patients. However, longer survival is accompanied by increased incidence of comorbidities due, in part, to drug side effects and toxicities. It is well accepted that inflammation and tumorigenesis are linked. Because peroxisome proliferator-activated receptor (PPAR-γ agonists are potent mediators of anti-inflammatory responses, it was a logical extension to examine the role of PPARγ agonists in the treatment and prevention of cancer. This paper has two objectives: first to highlight the potential uses for PPARγ agonists in anticancer therapy with special emphasis on their role when used as adjuvant or combined therapy in the treatment of hematological malignancies found in the vasculature, marrow, and eyes, and second, to review the potential role PPARγ and/or its ligands may have in modulating cancer-associated angiogenesis and tumor-stromal microenvironment crosstalk in bone marrow.

  13. An ontologically founded architecture for information systems in clinical and epidemiological research.

    Science.gov (United States)

    Uciteli, Alexandr; Groß, Silvia; Kireyev, Sergej; Herre, Heinrich

    2011-08-09

    This paper presents an ontologically founded basic architecture for information systems, which are intended to capture, represent, and maintain metadata for various domains of clinical and epidemiological research. Clinical trials exhibit an important basis for clinical research, and the accurate specification of metadata and their documentation and application in clinical and epidemiological study projects represents a significant expense in the project preparation and has a relevant impact on the value and quality of these studies.An ontological foundation of an information system provides a semantic framework for the precise specification of those entities which are presented in this system. This semantic framework should be grounded, according to our approach, on a suitable top-level ontology. Such an ontological foundation leads to a deeper understanding of the entities of the domain under consideration, and provides a common unifying semantic basis, which supports the integration of data and the interoperability between different information systems.The intended information systems will be applied to the field of clinical and epidemiological research and will provide, depending on the application context, a variety of functionalities. In the present paper, we focus on a basic architecture which might be common to all such information systems. The research, set forth in this paper, is included in a broader framework of clinical research and continues the work of the IMISE on these topics.

  14. [Dust particles mainly containing silicon found in the cells of granulomas of sarcoidosis].

    Science.gov (United States)

    Liu, Hong-gang

    2006-06-01

    To investigate if there are dust particles in the cells of granulomas of sarcoidosis and analyze its composition and the possible correlation between the sarcoidosis and the composition of dust particles. The samples of 50 patients with sarcoidosis and 6 patients with silicosis as control were collected by biopsy and/or autopsy sampling. The pathological varieties of the granulomas and the situation of the dust particles within the cells of granulomas were observed using hematoxylin and eosin staining, Warthin-Starry silver staining, immunohistochemistry staining as well as the transmission electron microscope, and the X-Ray spectrum chemical element analysis in the samples from these two kinds of diseases. The dust particles containing silicon as the main chemical element were present in epithelioid cells and multinucleate giant cells in all the samples. The quantity of the particles deposited in sarcoidosis was less than that in the silicosis. Moreover, the dust cells were found in the granulomas and the visceral pleural lymphatic vessels in the pleura and the hilar pulmonary lymph nodes in sarcoidosis and silicosis. The pathological varieties of the granulomas in sarcoidosis and silicosis were similar. There are less silicon dust particles in the cells of granulomas of sarcoidosis than in those of the silicotic nodules, which indicates that the silicon dust particles may be related to the sarcoidosis.

  15. Leather material found on a 6th B.C. Chinese bronze sword: A technical study

    Science.gov (United States)

    Luo, Wugan; Si, Yi; Wang, Hongmin; Qin, Ying; Huang, Fengchun; Wang, Changsui

    2011-09-01

    During July to November, 2006, an important archaeological excavation was conducted in Yun country, Hubei province, southern China. Chinese archaeologists found some remnant of leather materials, covered with red pigments, on a 6th century B.C. Chinese bronze sword. To understand the technology/ies that may have been utilized for manufacturing the leathers, a combined of Raman spectroscopy, FT-IR and XRF was thus applied to the remnant of leather materials. Raman analyses showed that red pigment on the leather was cinnabar (HgS). FT-IR and XRF analyses indicated that the content of some elements, such as Ca (existing as CaCO 3) and Fe (existing as Fe 2O 3), were much higher than those in the surrounding grave soil. The results inferred an application of lime depilation and retting, and the Fe-Al compound salt as tanning agent. And it was furthermore implicated that the Fe-Al salt tanning technique had been developed in the middle and late Spring and Autumn Period of China.

  16. A Biomarker Found in Cadmium Exposed Residents of Thailand by Metabolome Analysis

    Directory of Open Access Journals (Sweden)

    Dhitiwass Suvagandha

    2014-04-01

    Full Text Available First, the urinary metabolic profiling by gas chromatography-mass spectrometry (GC-MS, was performed to compare ten cadmium (Cd toxicosis cases from a Cd-polluted area in Mae Sot (Thailand with gender-matched healthy controls. Orthogonal partial list square-discrimination analysis was used to identify new biomarker candidates in highly Cd exposed toxicosis cases with remarkable renal tubular dysfunction. The results of the first step of this study showed that urinary citrate was a negative marker and myo-inositol was a positive marker for Cd toxicosis in Thailand. In the second step, we measured urinary citrate in the residents (168 Cd-exposed subjects and 100 controls and found significantly lower levels of urinary citrate and higher ratios of calcium/citrate and magnesium/citrate, which are risk factors for nephrolithiasis, in highly Cd-exposed residents. Additionally, this inverse association of urinary citrate with urinary Cd was observed after adjustment for age, smoking and renal tubular dysfunction, suggesting a direct effect of Cd on citrate metabolism. These results indicate that urinary citrate is a useful biomarker for the adverse health effects of Cd exposure in a Thai population with a high prevalence of nephrolithiasis.

  17. A Novel Neural Prediction Error Found in Anterior Cingulate Cortex Ensembles.

    Science.gov (United States)

    Hyman, James Michael; Holroyd, Clay Brian; Seamans, Jeremy Keith

    2017-07-19

    The function of the anterior cingulate cortex (ACC) remains controversial, yet many theories suggest a role in behavioral adaptation, partly because a robust event-related potential, the feedback-related negativity (FN), is evoked over the ACC whenever expectations are violated. We recorded from the ACC as rats performed a task identical to one that reliably evokes an FN in humans. A subset of neurons was found that encoded expected outcomes as abstract outcome representations. The degree to which a reward/non-reward outcome representation emerged during a trial depended on the history of outcomes that preceded it. A prediction error was generated on incongruent trials as the ensembles shifted from representing the expected to the actual outcome, at the same time point we have previously reported an FN in the local field potential. The results describe a novel mode of prediction error signaling by ACC neurons that is associated with the generation of an FN. Copyright © 2017 Elsevier Inc. All rights reserved.

  18. Estimation of the number of wild pigs found in the United States

    Energy Technology Data Exchange (ETDEWEB)

    Mayer, J. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

    2014-08-01

    Based on a compilation of three estimation approaches, the total nationwide population of wild pigs in the United States numbers approximately 6.3 million animals, with that total estimate ranging from 4.4 up to 11.3 million animals. The majority of these numbers (99 percent), which were encompassed by ten states (i.e., Alabama, Arkansas, California, Florida, Georgia, Louisiana, Mississippi, Oklahoma, South Carolina and Texas), were based on defined estimation methodologies (e.g., density estimates correlated to the total potential suitable wild pig habitat statewide, statewide harvest percentages, statewide agency surveys regarding wild pig distribution and numbers). In contrast to the pre-1990 estimates, none of these more recent efforts, collectively encompassing 99 percent of the total, were based solely on anecdotal information or speculation. To that end, one can defensibly state that the wild pigs found in the United States number in the millions of animals, with the nationwide population estimated to arguably vary from about four million up to about eleven million individuals.

  19. Found in translation: understanding the biology and behavior of experimental traumatic brain injury

    Science.gov (United States)

    Bondi, Corina O.; Semple, Bridgette D.; Noble-Haeusslein, Linda J.; Osier, Nicole D.; Carlson, Shaun W.; Dixon, C. Edward; Giza, Christopher C.; Kline, Anthony E.

    2014-01-01

    BONDI, C.O., B.D. Semple, L.J. Noble-Haeusslein, N.D. Osier, S.W. Carlson, C.E. Dixon, C.C. Giza and A.E. Kline. Found in translation: understanding the biology and behavior of experimental traumatic brain injury. NEUROSCI BIOBEHAV REV. The aim of this review is to discuss in greater detail the topics covered in the recent symposium entitled “Traumatic brain injury: laboratory and clinical perspectives,” presented at the 2014 International Behavioral Neuroscience Society annual meeting. Herein we review contemporary laboratory models of traumatic brain injury (TBI) including common assays for sensorimotor and cognitive behavior. New modalities to evaluate social behavior after injury to the developing brain, as well as the attentional set-shifting test (AST) as a measure of executive function in TBI, will be highlighted. Environmental enrichment (EE) will be discussed as a preclinical model of neurorehabilitation, and finally, an evidence-based approach to sports-related concussion will be considered. The review consists predominantly of published data, but some discussion of ongoing or future directions is provided. PMID:25496906

  20. Unravelling the interactions among microbial populations found in activated sludge during biofilm formation.

    Science.gov (United States)

    Liébana, Raquel; Arregui, Lucía; Santos, Antonio; Murciano, Antonio; Marquina, Domingo; Serrano, Susana

    2016-09-01

    Microorganisms colonize surfaces and develop biofilms through interactions that are not yet thoroughly understood, with important implications for water and wastewater systems. This study investigated the interactions between N-acyl homoserine lactone (AHL)-producing bacteria, yeasts and protists, and their contribution to biofilm development. Sixty-one bacterial strains were isolated from activated sludge and screened for AHL production, with Aeromonas sp. found to be the dominant AHL producer. Shewanella xiamenensis, Aeromonas allosaccharophila, Acinetobacter junii and Pseudomonas aeruginosa recorded the highest adherence capabilities, with S. xiamenensis being the most effective in surface colonization. Additionally, highly significant interactions (i.e. synergic or antagonistic) were described for dual and multistrain mixtures of bacterial strains (P. aeruginosa, S. xiamenensis, A. junii and Pseudomonas stutzeri), as well as for strongly adherent bacteria co-cultured with yeasts. In this last case, the adhered biomass in co-cultures was lower than the monospecific biofilms of bacteria and yeast, with biofilm observations by microscopy suggesting that bacteria had an antagonist effect on the whole or part of the yeast population. Finally, protist predation by Euplotes sp. and Paramecium sp. on Aeromonas hydrophila biofilms not only failed to reduce biofilm formation, but also recorded unexpected results leading to the development of aggregates of high density and complexity. © FEMS 2016. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  1. A Survey of Bee Species Found Pollinating Watermelons in the Lower Rio Grande Valley of Texas

    Directory of Open Access Journals (Sweden)

    C. S. Henne

    2012-01-01

    Full Text Available Using a combination of flower traps and visual observations, we surveyed three watermelon (Citrullus lanatus (Thunb. Matsum. & Nakai fields in the Lower Rio Grande Valley to determine what bees inhabit this crop in this region. No managed honey bee (Apis mellifera L. hives were in any of the fields; however, two contained managed hives of the common eastern bumble bee, Bombus impatiens (Cresson. A total of 15 species were collected or observed from all three fields combined. Of these species, only four were found to be very abundant: Agapostemon angelicus Cockerell/texanus Cresson, A. mellifera, Lasioglossum coactum (Cresson, and Melissodes thelypodii Cockerell. Apis mellifera comprised 46% of all bees collected from all three fields combined and was highly abundant in two of the three fields. In the third field, however, A. mellifera and Agapostemon angelicus/texanus were equally abundant. Surprisingly, B. impatiens comprised only 1% of the total bees surveyed in all three fields combined, despite two of the fields having several managed hives each. As B. impatiens is not native to this region, it was not surprising that none were collected or observed in the field with no managed hives.

  2. Long-lasting Extreme Magnetic Storm Activities in 1770 Found in Historical Documents

    Science.gov (United States)

    Hayakawa, Hisashi; Iwahashi, Kiyomi; Ebihara, Yusuke; Tamazawa, Harufumi; Shibata, Kazunari; Knipp, Delores J.; Kawamura, Akito D.; Hattori, Kentaro; Mase, Kumiko; Nakanishi, Ichiro; Isobe, Hiroaki

    2017-12-01

    Dim red aurora at low magnetic latitudes is a visual and recognized manifestation of magnetic storms. The great low-latitude auroral displays seen throughout East Asia on 1770 September 16-18 are considered to manifest one of the greatest storms. Recently found, 111 historical documents in East Asia attest that these low-latitude auroral displays appeared in succession for almost nine nights during 1770 September 10-19 in low magnetic latitude areas (<30°). This suggests that the duration of the great magnetic storm is much longer than usual. Sunspot drawings from 1770 reveal that the sunspot areas were twice as large as those observed in another great storm of 1859, which substantiates these unusual storm activities in 1770. These spots likely ejected several huge, sequential magnetic structures in short duration into interplanetary space, resulting in spectacular worldwide aurorae in mid-September of 1770. These findings provide new insight into the history, duration, and effects of extreme magnetic storms that may be valuable for those who need to mitigate against extreme events.

  3. Characterization of Peptides Found in Unprocessed and Extruded Amaranth (Amaranthus hypochondriacus Pepsin/Pancreatin Hydrolysates

    Directory of Open Access Journals (Sweden)

    Alvaro Montoya-Rodríguez

    2015-04-01

    Full Text Available The objectives of this study were to characterize peptides found in unprocessed amaranth hydrolysates (UAH and extruded amaranth hydrolysates (EAH and to determine the effect of the hydrolysis time on the profile of peptides produced. Amaranth grain was extruded in a single screw extruder at 125 °C of extrusion temperature and 130 rpm of screw speed. Unprocessed and extruded amaranth flour were hydrolyzed with pepsin/pancreatin enzymes following a kinetic at 10, 25, 60, 90, 120 and 180 min for each enzyme. After 180 min of pepsin hydrolysis, aliquots were taken at each time during pancreatin hydrolysis to characterize the hydrolysates by MALDI-TOF/MS-MS. Molecular masses (MM (527, 567, 802, 984, 1295, 1545, 2034 and 2064 Da of peptides appeared consistently during hydrolysis, showing high intensity at 10 min (2064 Da, 120 min (802 Da and 180 min (567 Da in UAH. EAH showed high intensity at 10 min (2034 Da and 120 min (984, 1295 and 1545 Da. Extrusion produced more peptides with MM lower than 1000 Da immediately after 10 min of hydrolysis. Hydrolysis time impacted on the peptide profile, as longer the time lower the MM in both amaranth hydrolysates. Sequences obtained were analyzed for their biological activity at BIOPEP, showing important inhibitory activities related to chronic diseases. These peptides could be used as a food ingredient/supplement in a healthy diet to prevent the risk to develop chronic diseases.

  4. Transition, privatization and monetary arrangements in the countries founded on the territory of former Yugoslavia

    Directory of Open Access Journals (Sweden)

    Marko Košak

    2011-12-01

    Full Text Available The aim of our research was to compare the methods of privatization of social ownership and monetary system in the countries of former Yugoslavia with the privatization mode and monetary arrangement that could be considered as optimal. By applying the method of comparative analysis, it has been found out that the way of socially-owned enterprises being privatized and monetary regulations implemented had the crucial impact on the transition in the countries of former Yugoslavia. In fact, the chosen methods of privatization and monetary arrangements applied in these countries have established economies of uncompetitive enterprises. Privatization was either macro-economically harmful for the domestic savings and capital formation and / or unjust for people. In addition, our analyses have proved that the monetary regulation and foreign exchange policy were either not implemented at all or too little to neutralize the negative consequences of selling companies to foreign investors on the foreign exchange rate. The same goes for the combination of monetary policy and foreign exchange rate policy that should have been implemented so as to prevent speculative import and export of short-term capital. For the countries that have not joined the EU yet, it might be helpful to comply with the conclusions of our research and examine their path toward a market economy.

  5. Bronchial abnormalities found in a consecutive series of 40 brachycephalic dogs.

    Science.gov (United States)

    De Lorenzi, Davide; Bertoncello, Diana; Drigo, Michele

    2009-10-01

    To detect abnormalities of the lower respiratory tract (trachea, principal bronchi, and lobar bronchi) in brachycephalic dogs by use of endoscopy, evaluate the correlation between laryngeal collapse and bronchial abnormalities, and determine whether dogs with bronchial abnormalities have a less favorable postsurgical long-term outcome following correction of brachycephalic syndrome. Prospective case series study. 40 client-owned brachycephalic dogs with stertorous breathing and clinical signs of respiratory distress. Brachycephalic dogs anesthetized for pharyngoscopy and laryngoscopy between January 2007 and June 2008 underwent flexible bronchoscopy for systematic evaluation of the principal and lobar bronchi. For dogs that underwent surgical correction of any component of brachycephalic syndrome, owners rated surgical outcome during a follow-up telephone survey. Correlation between laryngeal collapse and bronchial abnormalities and association between bronchial abnormalities and long-term outcome were assessed. Pugs (n = 20), English Bulldogs (13), and French Bulldogs (7) were affected. A fixed bronchial collapse was recognized in 35 of 40 dogs with a total of 94 bronchial stenoses. Abnormalities were irregularly distributed between hemithoraces; 15 of 94 bronchial abnormalities were detected in the right bronchial system, and 79 of 94 were detected in the left. The left cranial bronchus was the most commonly affected structure, and Pugs were the most severely affected breed. Laryngeal collapse was significantly correlated with severe bronchial collapse; no significant correlation was found between severity of bronchial abnormalities and postsurgical outcome. Bronchial collapse was a common finding in brachycephalic dogs, and long-term postsurgical outcome was not affected by bronchial stenosis.

  6. CDKN2A and MC1R variants found in Cypriot patients diagnosed with cutaneous melanoma.

    Science.gov (United States)

    Koulermou, Georgia; Shammas, Christos; Vassiliou, Andreas; Kyriakides, Tassos C; Costi, Constantina; Neocleous, Vassos; Phylactou, Leonidas A; Pantelidou, Maria

    2017-03-01

    The prevalence of genetic variants associated to cutaneous melanoma (CM) has never been determined within Cypriot melanomas. This study evaluates the frequency of variants in cyclin-dependent kinase inhibitor 2A (CDKN2A) and melanocortin-1 receptor (MC1R) in 32 patients diagnosed with CM. Other characteristics and risk factors were also assessed. CDKN2A p.Ala148Thr was detected in three of 32 patients, while the control group revealed no variations within CDKN2A. MC1R screening in 32 patients revealed the following variations: p.Val60Leu in 11 patients, p.Arg142His in four patients, p.Thr314Thr in one patient, p.Arg160Trp in one patient, p.Val92Met/p.Thr314Thr in one patient and p.Val92Met/p.Arg142His/p.Thr314Thr in one patient. The control group revealed only p.Val60Leu (in 10 of 45 individuals), which is frequently found in general populations. Two unrelated patients carried CDKN2A p.Ala148Thr in combination with MC1R p.Arg142His, suggesting digenic inheritance that may provide evidence of different gene variants acting synergistically to contribute for CM development. This study confirms the presence of CDKN2A and MC1R variants among Cypriot melanomas and supports existing evidence of a role for these variants in susceptibility to melanoma.

  7. Fungi found in Mediterranean and North Sea sponges: how specific are they?

    Directory of Open Access Journals (Sweden)

    Mohd Azrul Naim

    2017-09-01

    Full Text Available Fungi and other eukaryotes represent one of the last frontiers of microbial diversity in the sponge holobiont. In this study we employed pyrosequencing of 18S ribosomal RNA gene amplicons containing the V7 and V8 hypervariable regions to explore the fungal diversity of seven sponge species from the North Sea and the Mediterranean Sea. For most sponges, fungi were present at a low relative abundance averaging 0.75% of the 18S rRNA gene reads. In total, 44 fungal OTUs (operational taxonomic units were detected in sponges, and 28 of these OTUs were also found in seawater. Twenty-two of the sponge-associated OTUs were identified as yeasts (mainly Malasseziales, representing 84% of the fungal reads. Several OTUs were related to fungal sequences previously retrieved from other sponges, but all OTUs were also related to fungi from other biological sources, such as seawater, sediments, lakes and anaerobic digesters. Therefore our data, supported by currently available data, point in the direction of mostly accidental presence of fungi in sponges and do not support the existence of a sponge-specific fungal community.

  8. Role of relative humidity in colony founding and queen survivorship in two carpenter ant species.

    Science.gov (United States)

    Mankowski, Mark E; Morrell, J J

    2011-06-01

    Conditions necessary for optimal colony foundation in two carpenter ant species, Camponotus modoc Wheeler and Camponotus vicinus Mayr, were studied. Camponotus modoc and C. vicinus queens were placed in Douglas-fir, Pseudotsuga menziesii (Mirb. Franco) and Styrofoam blocks conditioned in sealed chambers at 70, 80, or 100% RH. Nanitic workers produced after 12 wk were used to assess the effects of substrate and moisture content on colony initiation. Queens of C. vicinus in Douglas-fir and Styrofoam produced worker numbers that did not differ significantly with moisture content; however, the number of colonies initiated by C. modoc differed significantly with moisture content. The results indicate that colony founding in C. vicinus is less sensitive to moisture content than C. modoc for Douglas-fir and Styrofoam. In another test, groups of queens of each species were exposed to 20, 50, 70, and 100% RH and the time until 50% mortality occurred was recorded for each species. C. vicinus lived significantly longer at each of the test humidities than C. modoc, suggesting that the former species is adapted to better survive under xeric conditions.

  9. The initial peopling of the Americas: A growing number of founding mitochondrial genomes from Beringia

    Science.gov (United States)

    Perego, Ugo A.; Angerhofer, Norman; Pala, Maria; Olivieri, Anna; Lancioni, Hovirag; Kashani, Baharak Hooshiar; Carossa, Valeria; Ekins, Jayne E.; Gómez-Carballa, Alberto; Huber, Gabriela; Zimmermann, Bettina; Corach, Daniel; Babudri, Nora; Panara, Fausto; Myres, Natalie M.; Parson, Walther; Semino, Ornella; Salas, Antonio; Woodward, Scott R.; Achilli, Alessandro; Torroni, Antonio

    2010-01-01

    Pan-American mitochondrial DNA (mtDNA) haplogroup C1 has been recently subdivided into three branches, two of which (C1b and C1c) are characterized by ages and geographical distributions that are indicative of an early arrival from Beringia with Paleo-Indians. In contrast, the estimated ages of C1d—the third subset of C1—looked too young to fit the above scenario. To define the origin of this enigmatic C1 branch, we completely sequenced 63 C1d mitochondrial genomes from a wide range of geographically diverse, mixed, and indigenous American populations. The revised phylogeny not only brings the age of C1d within the range of that of its two sister clades, but reveals that there were two C1d founder genomes for Paleo-Indians. Thus, the recognized maternal founding lineages of Native Americans are at least 15, indicating that the overall number of Beringian or Asian founder mitochondrial genomes will probably increase extensively when all Native American haplogroups reach the same level of phylogenetic and genomic resolution as obtained here for C1d. PMID:20587512

  10. Characteristics of medication advertisements found in US women’s fashion magazines

    Science.gov (United States)

    Mongiovi, Jennifer; Clarke Hillyer, Grace; Basch, Corey H.; Ethan, Danna; Hammond, Rodney

    2017-01-01

    Background: Although prescriptions are dispensed at discretion of medical professionals, many pharmaceutical companies use direct-to-consumer (DTC) advertising to increase sales. Over-the-counter (OTC) medications are similarly marketed. Methods: We examined the content of advertisements in 38 issues of 9 popular US women’s fashion magazines. We evaluated target audience, health condition, product availability, message appeal, target to females, and mention of potential side effects and benefits. Results: Sixty total medication advertisements were identified, 58.3% (95% CI: 45.8, 70.8) for prescription products. In magazines targeted to non-Hispanic Whites, >65% of advertisements were for OTC medications whereas 80% (95% CI: 66.7, 94.5) of advertisements found in Black/Latina magazines were for prescription medications. The rational appeal was used most commonly in non-Hispanic White magazines (75.9%; 95% CI: 60.3, 91.5). Emotional appeal was featured more often in prescription advertisements magazines (60.0; 95% CI:43.8, 76.2) compared to OTC (8.0; 95% CI: -2.6, 18.6). Conclusion: Although emotional appeal may be effective for selling medication to women, it often does not completely inform consumers of potential risks. PMID:28058239

  11. Genotyping and Axenic Growth of Coxiella burnetii Isolates Found in the United States Environment.

    Science.gov (United States)

    Kersh, Gilbert J; Priestley, Rachael A; Hornstra, Heidie M; Self, Joshua S; Fitzpatrick, Kelly A; Biggerstaff, Brad J; Keim, Paul; Pearson, Talima; Massung, Robert F

    2016-09-01

    Coxiella burnetii is a gram-negative bacterium that is the etiologic agent of the zoonotic disease Q fever. Common reservoirs of C. burnetii include sheep, goats, and cattle. These animals shed C. burnetii into the environment, and humans are infected by inhalation of aerosols. A survey of 1622 environmental samples taken across the United States in 2006-2008 found that 23.8% of the samples contained C. burnetii DNA. To identify the strains circulating in the U.S. environment, DNA from these environmental samples was genotyped using an SNP-based approach to derive sequence types (ST) that are also compatible with multispacer sequence typing methods. Three different sequence types were observed in 31 samples taken from 19 locations. ST8 was associated with goats and ST20 with dairy cattle. ST16/26 was detected in locations with exposure to various animals and also in locations with no direct animal contact. Viable isolates were obtained for all three sequence types, but only the ST20 and ST16/26 isolates grew in acidified citrate cysteine medium (ACCM)-2 axenic media. Examination of a variety of isolates with different sequence types showed that ST8 and closely related isolates did not grow in ACCM-2. These results suggest that a limited number of C. burnetii sequence types are circulating in the U.S. environment and these strains have close associations with specific reservoir species. Growth in ACCM-2 may not be suitable for isolation of many C. burnetii strains.

  12. Anti-inflammatory and antibacterial profiles of selected compounds found in South African propolis

    Directory of Open Access Journals (Sweden)

    S. Buthelezi

    2010-02-01

    Full Text Available Propolis is a complex resinous substance manufactured by honey bees to scaffold and protect the hive against pathogens. Although it has been widely used for its medicinal properties, it is unknown whether the activity depends on the concentrations of specific constituents or on potentiation between these. This study describes (1 the individual topical anti-inflammatory activities of selected flavonoids commonly found in propolis, and (2 their antibacterial activities, alone or in combination with the non-flavonoid caffeic acid phenethyl ester (CAPE. For the anti-inflammatory activities, the reduction in croton oil-induced oedema in a mouse model, after topical application of quercetin and galangin for 3 h, was more than 50%, while after 6 h of treatment the reduction was less then 50%. By contrast, the suppressive activity of luteolin was about 30% and 50%, for treatments of 3 h and 6 h, respectively. The maximum inhibition of the growth of Staphylococcus aureus by each of CAPE, eriodictyol and quercetin was about 20%, while luteolin was inactive. When combined with CAPE, potentiation of the antibacterial effect was observed in the case of luteolin, but antagonism was observed when combined with either eriodictyol or quercetin. The propolis flavonoids each appear to have significant anti-inflammatory activity while their antibacterial activities are somewhat weaker and significant only when luteolin was combined with CAPE.

  13. Two potent cytochrome P450 2D6 inhibitors found in Rhodiola rosea.

    Science.gov (United States)

    Xu, Wen; Zhang, Tingting; Wang, Zhi; Liu, Tao; Liu, Yanping; Cao, Zhihong; Sui, Zhongguo

    2013-12-01

    Throughout the world, in particular in Russia, Northern Europe and China, Rhodiola species are used as herb supplements. Previously, we found that the extract of Rhodiola rosea, one of the most widely used Rhodiola species, had an inhibitory effect on the catalytic activity of cytochrome P450 2D6. Here, its inhibitory components were identified. A human liver microsomal in vitro system was used with dextromethorphan as substrate. The production rate of destrorphan, a metabolite of dextromethorphan, was used to measure enzyme activity. The concentration of destrorphan in the samples was measured using LC-MS/MS. Inhibitory activity of eight main components from Rhodiola rosea was evaluated. Rhodiosin and rhodionin showed inhibitory activity with IC50 values of 0.761 microM and 0.420 microM, respectively. The other components showed no obvious inhibition (with a residual enzyme activity of more than 90%). Both rhodiosin and rhodionin were determined to be non-competitive inhibitors with Ki values of 0.769 microM and 0.535 microM. Two of the main Rhodiola rosea compounds, rhodiosin and rhodionin, can inhibit cytochrome P450 2D6 non-competitively with high specificity which could have implications for interactions with co-administered drugs.

  14. Clostridium botulinum Spores Found in Honey from Small Apiaries in Poland

    Directory of Open Access Journals (Sweden)

    Wojtacka Joanna

    2016-12-01

    Full Text Available A total of 102 honey samples collected from small apiaries (≤ 20 hives in Poland were analysed for the presence of Clostridium botulinum spores. The samples were prepared using the dilution centrifugation method and cultured in parallel in cooked meat medium (CMM and tripticase peptone glucose yeast (TPGY enrichment broths. Identification of toxin types A, B, and E of Clostridium botulinum strains was performed with the use of the multiplex PCR method. Positive samples were also subjected to quantitative analysis with the use of Clostridium botulinum Isolation Agar Base (CBAB. The prevalence analysis showed 22 (21.6% samples contaminated with C. botulinum spores. The major serotype detected was botulin neurotoxin type A – 16 (72.7% whereas type B was found in 3 (13.6% honey samples and type E also only in 3 (13.6% honey samples. Dual-toxin-producing strains were noted. The average quantity of spores in PCR - C. botulinum positive samples was 190 in 1 gram of honey.

  15. High incidence of oncogenic HPV genotypes found in women from Southern Brazil

    Directory of Open Access Journals (Sweden)

    Ludmila G Entiauspe

    2014-06-01

    Full Text Available Oncogenic HPV genotypes are strongly associated with premalignant and malignant cervical lesion. The purpose was to determine human papillomavirus (HPV prevalence and genotypes, and to estimate cervical cancer risk factor associations. Cervical samples were obtained from 251 women seeking gynecological care at the Pelotas School of Medicine Clinic. This is a cross-sectional study. HPV-DNA was amplified by nested-PCR using MY09/11 and GP5/6 primers, and the sequencing was used for genotyping. Sociodemographic and behavioral risk factors were obtained by closed questionnaire, and its relationship to HPV infection prevalence were analyzed. Statistical analyses were performed using SPSS 16.0 software, and differences were considered significant at p < 0.05. As results, the prevalence of HPV infection was 29.9%. The most frequent genotype was HPV-16 (41.3%, followed by HPV-18 (17.3%, and HPV-33 (9.3%. Others nine HPV genotypes were also found. On this population, prevalence of oncogenic HPV genotypes was high, but does not seem to confer relationship with the risk factors investigated. Future investigations in larger populations are necessary, for the proposition of more appropriated monitoring strategies and treatment according to the Brazilian health service reality, as well as patients.

  16. High incidence of oncogenic HPV genotypes found in women from Southern Brazil.

    Science.gov (United States)

    Entiauspe, Ludmila G; Silveira, Mariângela; Nunes, Emily M; Basgalupp, Suélen P; Stauffert, Dulce; Dellagostin, Odir A; Collares, Tiago; Seixas, Fabiana K

    2014-01-01

    Oncogenic HPV genotypes are strongly associated with premalignant and malignant cervical lesion. The purpose was to determine human papillomavirus (HPV) prevalence and genotypes, and to estimate cervical cancer risk factor associations. Cervical samples were obtained from 251 women seeking gynecological care at the Pelotas School of Medicine Clinic. This is a cross-sectional study. HPV-DNA was amplified by nested-PCR using MY09/11 and GP5/6 primers, and the sequencing was used for genotyping. Sociodemographic and behavioral risk factors were obtained by closed questionnaire, and its relationship to HPV infection prevalence were analyzed. Statistical analyses were performed using SPSS 16.0 software, and differences were considered significant at p HPV infection was 29.9%. The most frequent genotype was HPV-16 (41.3%), followed by HPV-18 (17.3%), and HPV-33 (9.3%). Others nine HPV genotypes were also found. On this population, prevalence of oncogenic HPV genotypes was high, but does not seem to confer relationship with the risk factors investigated. Future investigations in larger populations are necessary, for the proposition of more appropriated monitoring strategies and treatment according to the Brazilian health service reality, as well as patients.

  17. Distinction among the puparia of three blowfly species (Diptera: Calliphoridae) frequently found on unburied corpses.

    Science.gov (United States)

    Amorim, J A; Ribeiro, O B

    2001-08-01

    Calliphorid larvae are important in the decomposition of carrion. Since these larvae are present in the primary stages of succession on carcasses, they may be important indicators of death time and the movement of corpses in homicide investigations. In this study we examined the morphological differences among puparia of Chrysomya megacephala, C. putoria and Cochliomyia macellaria. Puparia of the three species (N=30, each) were obtained from the F2 generation bred in culture medium at 25 degrees C, and 60% relative humidity on a 12 h photoperiod. The interspecific differences found were related to the conspicuousness of six tubercles located in the region near the posterior spiracles and to the distance between the two peritrema involving the spiracles. The latter were (mean +/- SD) 15.2 +/- 3.1 microm for C. megacephala, 18.8 +/- 2.8 microm for C. putoria and 16.5 +/- 3.5 microm for C. macellaria. The results of the present study may be useful in forensic entomology.

  18. Distinction among the puparia of three blowfly species (Diptera: Calliphoridae frequently found on unburied corpses

    Directory of Open Access Journals (Sweden)

    Amorim JA

    2001-01-01

    Full Text Available Calliphorid larvae are important in the decomposition of carrion. Since these larvae are present in the primary stages of succession on carcasses, they may be important indicators of death time and the movement of corpses in homicide investigations. In this study we examined the morphological differences among puparia of Chrysomya megacephala, C. putoria and Cochliomyia macellaria. Puparia of the three species (N=30, each were obtained from the F2 generation bred in culture medium at 25° C, and 60% relative humidity on a 12 h photoperiod. The interspecific differences found were related to the conspicuousness of six tubercles located in the region near the posterior spiracles and to the distance between the two peritrema involving the spiracles. The latter were (mean ± SD 15.2 ± 3.1 mum for C. megacephala, 18.8 ± 2.8 mum for C. putoria and 16.5 ± 3.5 mum for C. macellaria. The results of the present study may be useful in forensic entomology.

  19. Fungi found in Mediterranean and North Sea sponges: how specific are they?

    Science.gov (United States)

    Naim, Mohd Azrul; Smidt, Hauke; Sipkema, Detmer

    2017-01-01

    Fungi and other eukaryotes represent one of the last frontiers of microbial diversity in the sponge holobiont. In this study we employed pyrosequencing of 18S ribosomal RNA gene amplicons containing the V7 and V8 hypervariable regions to explore the fungal diversity of seven sponge species from the North Sea and the Mediterranean Sea. For most sponges, fungi were present at a low relative abundance averaging 0.75% of the 18S rRNA gene reads. In total, 44 fungal OTUs (operational taxonomic units) were detected in sponges, and 28 of these OTUs were also found in seawater. Twenty-two of the sponge-associated OTUs were identified as yeasts (mainly Malasseziales), representing 84% of the fungal reads. Several OTUs were related to fungal sequences previously retrieved from other sponges, but all OTUs were also related to fungi from other biological sources, such as seawater, sediments, lakes and anaerobic digesters. Therefore our data, supported by currently available data, point in the direction of mostly accidental presence of fungi in sponges and do not support the existence of a sponge-specific fungal community.

  20. Plant Species Restoration: Effects of Different Founding Patterns on Sustaining Future Population Size and Genetic Diversity

    Directory of Open Access Journals (Sweden)

    Stephan Pelikan

    2013-03-01

    Full Text Available Efforts to sustain the earth’s biodiversity will include the establishment and manipulation of isolated rescue populations, derived either via in situ fragmentation, or under ex situ circumstances. For target species, especially those with limited propagation resources, major goals of such projects include both the optimization of population size and the preservation of genetic diversity. Such rescue populations will be founded in a variety of ways, but little is known about how the geometric patterning of founders can affect population growth and genetic diversity retention. We have developed a computer program, NEWGARDEN, to investigate this issue for plant species that vary in life history characteristics. To use NEWGARDEN, input files are created that specify the size and structure of the preserve, the positioning and genetic diversity of the founders, and life history characteristics of the species (e.g., age-specific reproduction and mortality; gene dispersal distances; rates of selfing, etc.. The program conducts matings with consequent offspring establishment such that the virtual population develops through generations as constrained by the input. Output statistics allow comparisons of population development for populations that differ in one or more input conditions. Here, with NEWGARDEN analyses modeling a triennial species, we show that rescue population project managers will often have to carefully consider the geometric placement of founders to minimize effort expended while maximizing population growth and conservation of genetic diversity, such considerations being heavily dependent on the life history characteristics of particular species.

  1. Transcriptome analysis of Gerbera hybrid: including in silico confirmation of defence genes found

    Directory of Open Access Journals (Sweden)

    Yiqian eFu

    2016-03-01

    Full Text Available For the ornamental crop Gerbera hybrida, breeding at the moment is done using conventional methods. As this has drawbacks in breeding speed and efficiency, especially for complex traits like disease resistance, we set out to develop genomic resources. The leaf and flower bud transcriptomes of four parents, used to generate two gerbera populations, were sequenced using Illumina paired-end sequencing. In total, 36,770 contigs with an average length of 1397 bp were generated and these have been the starting point for SNP identification and annotation. The consensus contig sequences were used to map reads of individual parents, to identify genotype specific SNPs, and to assess the presence of common SNPs between genotypes.Comparison with the non-redundant protein database (nr showed that 29,146 contigs gave BLAST hits. Of sequences with blast results, 73.3% obtained a clear gene ontology (GO annotation. EST contigs coding for enzymes were found in Kyoto Encyclopedia of Genes and Genomes maps (KEGG. Through these annotated data and KEGG molecular interaction network, transcripts associated with the phenylpropanoid metabolism, other secondary metabolite biosynthesis pathways, phytohormone biosynthesis and signal transduction were analysed in more detail. Identifying genes involved in these processes could provide genetic and genomic resources for studying the mechanism of disease resistance in gerbera.

  2. In vitro combined cytotoxic effects of pesticide cocktails simultaneously found in the French diet.

    Science.gov (United States)

    Takakura, Natsuko; Sanders, Pascal; Fessard, Valérie; Le Hégarat, Ludovic

    2013-02-01

    Although human populations may be constantly exposed to complex pesticide mixtures through their diet, the human health risk of pesticide exposure is currently assessed on the basis of toxicity data on individual compounds. To investigate the combined toxic effects of pesticide cocktails previously identified in the French diet, we first studied the cytotoxicity induced by seven cocktails composed of two to six pesticides on human hepatic (HepG2) and colon (Caco-2) cell lines using the MTT and neutral red uptake assays. Secondly, we challenged to assess the combined effects of the two most cytotoxic cocktails by comparing the measured effects of the mixtures with the predictions based on additive effects on two concepts-independent action (IA) and concentration addition (CA). For the cocktail composed of dichlorodiphenyltrichloroethane (DDT) and dieldrin, the cytotoxicity of the equimolar cocktail proved greater than the additive effect estimated by the two concepts. Furthermore, apoptosis induction was higher in equimolar cocktail than predicted by summing the effects of DDT and dieldrin. Thus, some supra-additive toxicity was found in the DDT-dieldrin cocktail. Nevertheless, if IA and CA models could reveal combined effects of pesticide cocktails, an accurate evaluation remains challenging. Copyright © 2012 Elsevier Ltd. All rights reserved.

  3. How I Lost My Mind and Found the Meaning of “Life”

    Directory of Open Access Journals (Sweden)

    Herb Koplowitz

    2007-06-01

    Full Text Available By integrating philosophical rigor with practical examples and personal history and revelation, the author shares how he ended his quest to understand the concepts of life, mind, and soul and resolved the mind-body problem. The article relates the key insight garnered from Elliott Jaques that triggered a new, internally-consistent conceptual framework or paradigm. Founded on a unitary organism model of life, it replaced the mind-body-soul model. The logic of the new conceptual framework is developed through brief, methodical discussions that juxtapose choice and judgement with calculation, Newtonian physics, randomness, and self correction. The paper is grounded in the premise that our attempts to answer a question (e.g. "How do we think and judged?" are hindered by accepting an entity (e.g. mind whose only evidence is that the question exists. On that foundation, unitary arguments trace the author’s dissolution of concepts of mind, body, and soul and the spiritual. General implications of this framework are then applied to terminology and to the origin of life, abortion, and trading one duality for another. In relating some personal implications of this framework in daily life, the author makes the case for the value of simplicity in conceptual frameworks and the clarity that can result.

  4. How I Lost My Mind and Found the Meaning of “Life”

    Directory of Open Access Journals (Sweden)

    Herb Koplowitz

    2007-06-01

    Full Text Available By integrating philosophical rigor with practical examples and personal history and revelation, the author shares how he ended his quest to understand the concepts of life, mind, and soul and resolved the mind-body problem. The article relates the key insight garnered from Elliott Jaques that triggered a new, internally-consistent conceptual framework or paradigm. Founded on a unitary organism model of life, it replaced the mind-body-soul model. The paper is grounded in the premise that our attempts to answer a question (e.g., “How do we think and judge?” are hindered by accepting an entity (e.g., mind whose only evidence is that the question exists. The logic of the new conceptual framework is developed through brief, methodical discussions that juxtapose choice and judgement with calculation, Newtonian physics, randomness, and self correction. On that foundation, unitary arguments trace the author’s dissolution of concepts of mind, body, and soul and the spiritual. General implications of this framework are then applied to terminology and to the origin of life, abortion, and trading one duality for another. In relating some personal implications of this framework in daily life, the author makes the case for the value of simplicity in conceptual frameworks and the clarity that can result.

  5. Fungal infection of mantis shrimp (Oratosquilla oratoria) caused by two anamorphic fungi found in Japan.

    Science.gov (United States)

    Duc, Pham Minh; Hatai, Kishio; Kurata, Osamu; Tensha, Kozue; Yoshitaka, Uchida; Yaguchi, Takashi; Udagawa, Shun-ichi

    2009-05-01

    Two fungal pathogens of the mantis shrimp (Oratosquilla oratoria) in Yamaguchi and Aichi Prefectures, Japan are described as the new species Plectosporium oratosquillae and Acremonium sp. (a member of the Emericellopsis marine clade). Both fungi infect the gills of the mantis shrimp, which become brown or black due to melanization. The former species is characterized by its slow growth on artificial seawater yeast extract peptone glucose (PYGS) agar, pale yellow to pale orange or grayish yellow colonies, short cylindrical solitary phialides with a wavy tip, and one-celled ellipsoidal conidia. Although lacking the two-celled conidia demonstrated by the type species Plectosporium tabacinum, the taxonomic placement of the new species was confirmed by DNA sequence analysis of the internal transcribed spacer (ITS) region of ribosomal DNA (ITS1, 5.8S rDNA and ITS2). Acremonium sp., the other causal pathogen, differs from P. oratosquillae by its fast growth on PYGS agar, pale orange to salmon-colored colonies, long, slender conidiophores consisting of solitary phialides with tips lacking an undulate outline, and typically cylindrical conidia. Analysis of ITS and beta-tubulin gene sequences placed this fungus within the phylogenetically distinct Emericellopsis (anam. Acremonium) marine clade. Various physiological characteristics of both pathogens were also investigated. This is the first report of a fungal infection found on the mantis shrimp in Japan.

  6. Investigation of preservative efficacy and microbiological content of some cosmetics found on the market.

    Science.gov (United States)

    Birteksöz Tan, Ayşe Seher; Tüysüz, Mayram; Ötük, Gülten

    2013-01-01

    In this study, microbial content and preservative efficacy of various cosmetic products, which are produced and sold in markets of our country, were investigated. Microbial content and preservative efficacies of products were investigated according to United States Pharmacopeia (USP) method. Microorganism counts of out 14 of 93 cosmetic products were recovered in the range between 1.5 x 10(2)-5.5 x 10(5) cfu/ml. Staphylococcus aureus was the most common contaminant identified in samples (from six different products) and was followed by Burkholderia cepacia (from four different products). Gram negative organisms, including Pseudomonas aeruginosa and a yeast Candida krusei, were also isolated from samples. Escherichia coli and Salmonella sp. were not recovered from any of samples. Preservative efficacies of fourteen out of ninety-three products did not meet the general efficacy of antimicrobial preservation criteria of the USP. Among these fourteen products, degradation and color change by Aspergillus niger was observed in one of samples. According to results, it was observed that pathogen and potential pathogen microorganisms can be found in unused cosmetic products and also preservatives may be ineffective in preventing them. Thus, in order to prevent the contamination that can occur during production, manufacturers are required to manufacture products in compliance with wholesome manufacturing practices and, considering consumer health, it is necessary to add an effective preservative as determined by regulations.

  7. Biomechanical differences related to leg dominance were not found during a cutting task.

    Science.gov (United States)

    Greska, E K; Cortes, N; Ringleb, S I; Onate, J A; Van Lunen, B L

    2017-11-01

    Previous studies have shown conflicting information regarding leg dominance as an etiological factor for the risk of anterior cruciate ligament (ACL) injuries. It remains unclear if lower extremity neuromechanical limb asymmetries exist in experienced athletes. The purpose of this study was to evaluate lower extremity neuromechanical effects of leg dominance in female collegiate soccer athletes during an unanticipated side-step cutting task. Twenty female collegiate soccer players completed an unanticipated side-step cutting task, using their dominant and non-dominant legs. Kinematic and kinetic data were collected to quantify joint angles and forces, with wireless electromyography (EMG) quantifying muscle activity. MANOVA's were conducted to determine the effect of leg dominance on hip and knee mechanics at and between pre-contact, initial contact, peak knee adduction moment, and peak stance periods. Dependent variables consisted of peak time occurrences, hip and knee rotations and moments, ground reaction force, EMG amplitudes, stance time, and approach velocity. No significant differences were found for any variables at or between the periods of interest. Collegiate female soccer athletes exhibit similar movement patterns between dominant and non-dominant legs while performing a side-step cutting task, suggesting that leg dominance does not adversely influence known biomechanical non-contact ACL risk factors. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  8. Fungi found in Mediterranean and North Sea sponges: how specific are they?

    Science.gov (United States)

    Naim, Mohd Azrul; Smidt, Hauke

    2017-01-01

    Fungi and other eukaryotes represent one of the last frontiers of microbial diversity in the sponge holobiont. In this study we employed pyrosequencing of 18S ribosomal RNA gene amplicons containing the V7 and V8 hypervariable regions to explore the fungal diversity of seven sponge species from the North Sea and the Mediterranean Sea. For most sponges, fungi were present at a low relative abundance averaging 0.75% of the 18S rRNA gene reads. In total, 44 fungal OTUs (operational taxonomic units) were detected in sponges, and 28 of these OTUs were also found in seawater. Twenty-two of the sponge-associated OTUs were identified as yeasts (mainly Malasseziales), representing 84% of the fungal reads. Several OTUs were related to fungal sequences previously retrieved from other sponges, but all OTUs were also related to fungi from other biological sources, such as seawater, sediments, lakes and anaerobic digesters. Therefore our data, supported by currently available data, point in the direction of mostly accidental presence of fungi in sponges and do not support the existence of a sponge-specific fungal community. PMID:28894639

  9. Quality of claims and references found in Australian pharmacy journal advertisements.

    Science.gov (United States)

    Mandoh, Mona; Curtain, Colin Michael

    2017-10-01

    To evaluate the quality of pharmaceutical advertisement claims and supporting references in Australian pharmacy journals that target community pharmacists. All full-page advertisements for a medicinal product, found in two Australian pharmacy journals from the year 2012 to 2015 were included. Advertisement claims and references were evaluated by claim type (unambiguous to immeasurable) and level of evidence (strong to irrelevant) in supporting references. Two hundred and ninety distinct advertisements and 598 claims were identified, with a median of 2 claims per advertisement. Twenty-seven percent of claims were unambiguous, 40% were vague, 16% were emotive/immeasurable and 17% were non-clinical or other marketing claims. Half of all claims were referenced. Although 68% of unambiguous claims were referenced, 63% of those were supported by studies that were funded directly or indirectly by pharmaceutical companies. Only 13% of claims were supported with strong or moderate independent evidence. Pharmaceutical advertisements continue to present vague and emotive claims with little independent supporting evidence. Pharmacists need to be aware of these limitations when providing patient care. Increased awareness of this issue among pharmaceutical companies, Australian pharmaceutical journal publishers, regulators and pharmacists will assist in promoting optimised healthcare outcomes for the Australian public. © 2016 Royal Pharmaceutical Society.

  10. Multiple queens in founding colonies of the neotropical ant Pachycondyla striata Smith (Formicidae: Ponerinae).

    Science.gov (United States)

    Rodrigues, M S; Vilela, E F; Azevedo, D O; Hora, R R

    2011-01-01

    In social insects, the typical mode of colony foundation occurs when a single queen is inseminated by a male and establishes a new colony, although we can find interspecific and intraspecific variations in queen number and queen-mating frequencies in a single colony. This study aimed to verify the queen number in Pachycondyla striata (Smith) colonies and to evaluate the level of aggressiveness among workers. We collected 14 colonies of P. striata. The behaviors of individuals from five multiple-queen colonies maintained in laboratory were studied by the method of scan sampling. In order to evaluate aggressiveness, dyadic encounters among heterocolonial and homocolonial workers were performed. The results showed that colonies of P. striata can have two or more mated queens (polygynous colonies) besides to monogynous ones (colony containing one queen). Because in polygynous colonies the number of workers was relatively low, such colonies could represent colonies in the foundation phase that characterize a pleometrosis state. In fact, ovarian development analysis from queens showed that the number of queens in the colonies seemed to be unstable. Despite a few cases of oophagy (egg cannibalism), social hierarchy among queens is unclear in comparison to other Pachycondyla species. In addition, aggressiveness increased with distance among nests. Nearby colonies (less than 1 m apart) showed a low level of aggressiveness, suggesting the presence of polydomy, that is, a unique colony can occupy multiple nests. Polygyny associated to polydomy in founding colonies may confer benefits on growth and dispersion of colonies in the studied environments.

  11. Left-handed graduate students: difficulties found and proposals presented to daily life activities

    Directory of Open Access Journals (Sweden)

    Elisângela de Assis Amaroa

    2014-12-01

    Full Text Available This research aimed to identify, through the application of questionnaires, the daily difficulties of left-handed college students and to list their proposals to solve the problems found. One hundred thirty-eight left-handed students participated in the study. They answered a questionnaire composed of eight essay questions and five alternative questions which included information on laterality, school, labor and daily life activities, and on suggestions to improve their activities. It was verified that the main difficulties reported by left-handed college students on daily life, work, and school environment are opening cans, bad arrangement of objects in space, and inadequacy of school desks, respectively. Aiming to improve the performance of their activities within these three aspects, the most cited suggestions are related to improvement/availability of left-handed adapted desks and development of objects adapted to this group. The study shows data on difficulties and coherent suggestions, and the advances proposed are of easy solution and great value for such population.

  12. Bronze Age metal artefacts found on Cyprus - metal from Anatolia and the Western Mediterranean

    Directory of Open Access Journals (Sweden)

    Stos-Gale, Zofia A.

    2010-12-01

    Full Text Available Hundreds of Bronze Age metal artefacts excavated on archaeological sites in Cyprus have been analysed for their lead isotope and elemental composition in the Isotrace Laboratory, University of Oxford, in the years 1982-2002. In parallel, but in particular after 1995, hundreds of samples of minerals and slags collected from the mines and smelting sites around the Troodos Mountains were also analysed. Most of the results were published in various articles over the years, but the interpretation of some of the lead isotope data needs a current revision in view of new research conducted in Spain, Sardinia and southern France. It has been known that the lead isotope data for metal artefacts from the Cypriot Bronze Age sites shows that not all of the copper is consistent with origin from the Cypriot ores. In addition, the lead and silver artefacts found there must have been imported, because there are no lead or silver ores on Cyprus. The re-evaluation of the data shows that about 11 % of the analysed metal artefacts are consistent with the origin from the deposits in the Aegean and Turkey, while about 14 % with sources in the Western Mediterranean. This paper discusses in detail the current interpretation of the research into the sources of imported metal found in the Bronze Age context on Cyprus.

    Cientos de objetos de metal de la Edad del Bronce excavados en yacimientos de Chipre han sido analizados para conocer su composición elemental y sus isótopos de plomo en el Isotrace Laboratory de la Universidad de Oxford entre los años 1982 y 2002. Especialmente con posterioridad a 1995 cientos de muestras de minerales y escorias recogidas de minas y sitios de reducción de minerales localizadas en el entorno de las montañas de Troodos también fueron analizadas. La mayoría de los resultados fueron publicados en varios artículos a lo largo del tiempo, pero la interpretación de algunos análisis de isótopos de plomo necesitan de una revisión a

  13. Key identifiers and spelling conventions in MXit-lingo as found in conversations with Dr Math

    Directory of Open Access Journals (Sweden)

    Laurie Butgereit

    2012-07-01

    Full Text Available Different human languages look different from other human languages. To use a term from the computer industry, each human language has its own “look and feel”. European English speakers can easily recognise a phrase such as “Comment allez-vous?” as being written in French while the phrase “¿Habla usted español?” is written in Spanish. Each language has its own letter frequencies, word frequencies and other identifiers. This paper describes key identifiers in MXit lingo as found in Dr Math conversations. MXit is a mobile instant messaging system which originated in South Africa and is expanding to other countries. Dr Math is a mobile tutoring system which uses MXit as a communication protocol. Primary and secondary school pupils can receive help with the mathematics homework using the Dr Math tutoring system. The pupils use MXit on their cell phones and the tutors use traditional Internet workstations. After exploring how MXit lingo is written, this paper will briefly explore why MXit lingo is written the way it is. By identifying and describing the orthographic conventions visible in the spelling of MXit lingo, although with some theoretical support, insight into the purposeful and functional nature of written, mobile communication will be revealed. In highlighting spelling that is influenced by Black South African English, an attempt will be made to contribute to the empirical development of a field of study that explores the construction of words used in South African mobile communication. Keywords: MXit, Math, letters, writing, orthography Disciplines: Linguistics, mathematics, information technology

  14. Three extracellular dipeptidyl peptidases found in Aspergillus oryzae show varying substrate specificities.

    Science.gov (United States)

    Maeda, Hiroshi; Sakai, Daisuke; Kobayashi, Takuji; Morita, Hiroto; Okamoto, Ayako; Takeuchi, Michio; Kusumoto, Ken-Ichi; Amano, Hitoshi; Ishida, Hiroki; Yamagata, Youhei

    2016-06-01

    Three extracellular dipeptidyl peptidase genes, dppB, dppE, and dppF, were unveiled by sequence analysis of the Aspergillus oryzae genome. We investigated their differential enzymatic profiles, in order to gain an understanding of the diversity of these genes. The three dipeptidyl peptidases were expressed using Aspergillus nidulans as the host. Each recombinant enzyme was purified and subsequently characterized. The enzymes displayed similar optimum pH values, but optimum temperatures, pH stabilities, and substrate specificities varied. DppB was identified as a Xaa-Prolyl dipeptidyl peptidase, while DppE scissile substrates were similar to the substrates for Aspergillus fumigatus DPPV (AfDPPV). DppF was found to be a novel enzyme that could digest both substrates for A. fumigatus DPPIV and AfDPPV. Semi-quantitative PCR revealed that the transcription of dppB in A. oryzae was induced by protein substrates and repressed by the addition of an inorganic nitrogen source, despite the presence of protein substrates. The transcription of dppE depended on its growth time, while the transcription of dppF was not affected by the type of the nitrogen source in the medium, and it started during the early stage of the fungal growth. Based on these results, we conclude that these enzymes may represent the nutrition acquisition enzymes. Additionally, DppF may be one of the sensor peptidases responsible for the detection of the protein substrates in A. oryzae environment. DppB may be involved in nitrogen assimilation control, since the transcription of dppB was repressed by NaNO3, despite the presence of protein substrates.

  15. Adams-Harbertson protein precipitation-based wine tannin method found invalid.

    Science.gov (United States)

    Brooks, Larry; McCloskey, Leo; McKesson, Doug; Sylvan, Marshall

    2008-01-01

    The poor precision of the Adams-Harbertson wine tannin assay which was proposed for commercial winemaking, thereby creating the real possibility of quality control problems, is documented. The method is a version of the Hagerman and Butler protein precipitation-based tannin method. An extensive invalidation of the assay results with luxury wine data shows that the assay cannot distinguish bottled wine with reasonable accuracy. Five laboratories used Adams-Harbertson to assay 9 replicates each, of 3 bottled wines (n = 135) found in California supermarkets, with tannin concentrations of nominally 500 and 1000 ppm by high-performance liquid chromatography (HPLC). Reliability exceeded the +/-5% industry requirement by nominally 5 times (z-score based on 5% distribution). Coefficient of variation was +/-27%, making the standard deviation range 54% for Pinot Noir, 34% for Merlot, and 44% for Cabernet Sauvignon. Validity exceeded the 100% requirement. Intralaboratory validity recovery was 55-63%. Interwinery validity was 71-178% of the mean for Pinot Noir, 81-144% for Merlot, and 83-164% for Cabernet Sauvignon. Range as a function of the mean was 89% for Pinot Noir, 55% for Merlot, and 67% for Cabernet Sauvignon. Expect intermethod validity to be nominally 50%, i.e., percent recovery to HPLC. These statistically significant errors were predicted by the literature. First-order error is related to the tannin-protein equilibrium constant (Ka), as suggested by the original author, Hagerman, and the protein equivalence point error as suggested by Silber. This does not obviate second-order errors for tannin-protein analytical chemistry. Winemakers using the measurements risk making wines that are relatively more tannic than the measurements report.

  16. Asterionellopsis tropicalis (Bacillariophyceae): a new tropical species found in diatom accumulations.

    Science.gov (United States)

    Franco, Andréa de Oliveira da Rocha; They, Ng Haig; Canani, Luis Gustavo de Castro; Maggioni, Rodrigo; Odebrecht, Clarisse

    2016-10-01

    The diatom Asterionellopsis glacialis sensu lato forms high-density patches in the surf zone of some sandy beaches worldwide and was until recently considered a cosmopolitan species. With the recent description of four cryptic species, the identity of specimens found in these accumulations remains uncertain. In this study, diatom patches were sampled from two sandy beaches of the Brazilian coast: one tropical (Futuro Beach, 3° S; 38° W) and one subtropical (Cassino Beach, 32° S; 52° W). Fine structure of frustules and the sequencing of three phylogenetic markers revealed the subtropical strains to be A. guyunusae and the tropical strains to be a new species, here described as Asterionellopsis tropicalis sp. nov. A. tropicalis was differentiated morphologically by the number of striae in 10 μm at the foot pole and head (39-44; 38-45, respectively), from A. lenisilicea (46-55; 46-64), A. maritima (46-51; 46-60), and A. thurstonii (42-58; 55-70). The number of striae at the head region of the valvocopula (10 μm) helped to distinguish A. tropicalis (56-62) from A. guyunusae (61-64), but A. tropicalis was morphologically undistinguishable from A. glacialis. The sequence divergence from other identified Asterionellopsis species was 13%-16% (Cox1), 11%-12% (5.8S + ITS2) and 2%-6% (RbcL), and A. tropicalis formed a distinct monophyletic clade with high support in all analyzed phylogenetic trees (single or multi-locus). This work will aid in the understanding of the ecological and physiological diversity of diatom patches that are key to the trophic webs of sandy beaches. © 2016 Phycological Society of America.

  17. Five hTRPA1 Agonists Found in Indigenous Korean Mint, Agastache rugosa.

    Directory of Open Access Journals (Sweden)

    Hana Moon

    Full Text Available Transient receptor potential ankyrin1 (TRPA1 and transient receptor potential vanilloid 1 (TRPV1 are members of the TRP superfamily of structurally related, nonselective cation channels and mediators of several signaling pathways. Previously, we identified methyl syringate as an hTRPA1 agonist with efficacy against gastric emptying. The aim of this study was to find hTRPA1 and/or hTRPV1 activators in Agastache rugosa (Fisch. et Meyer O. Kuntze (A.rugosa, commonly known as Korean mint to improve hTRPA1-related phenomena. An extract of the stem and leaves of A.rugosa (Labiatae selectively activated hTRPA1 and hTRPV1. We next investigated the effects of commercially available compounds found in A.rugosa (acacetin, 4-allylanisole, p-anisaldehyde, apigenin 7-glucoside, L-carveol, β-caryophyllene, trans-p-methoxycinnamaldehyde, methyl eugenol, pachypodol, and rosmarinic acid on cultured hTRPA1- and hTRPV1-expressing cells. Of the ten compounds, L-carveol, trans-p-methoxycinnamaldehyde, methyl eugenol, 4-allylanisole, and p-anisaldehyde selectively activated hTRPA1, with EC50 values of 189.1±26.8, 29.8±14.9, 160.2±21.9, 1535±315.7, and 546.5±73.0 μM, respectively. The activities of these compounds were effectively inhibited by the hTRPA1 antagonists, ruthenium red and HC-030031. Although the five active compounds showed weaker calcium responses than allyl isothiocyanate (EC50=7.2±1.4 μM, our results suggest that these compounds from the stem and leaves of A.rugosa are specific and selective agonists of hTRPA1.

  18. Five hTRPA1 Agonists Found in Indigenous Korean Mint, Agastache rugosa.

    Science.gov (United States)

    Moon, Hana; Kim, Min Jung; Son, Hee Jin; Kweon, Hae-Jin; Kim, Jung Tae; Kim, Yiseul; Shim, Jaewon; Suh, Byung-Chang; Rhyu, Mee-Ra

    2015-01-01

    Transient receptor potential ankyrin1 (TRPA1) and transient receptor potential vanilloid 1 (TRPV1) are members of the TRP superfamily of structurally related, nonselective cation channels and mediators of several signaling pathways. Previously, we identified methyl syringate as an hTRPA1 agonist with efficacy against gastric emptying. The aim of this study was to find hTRPA1 and/or hTRPV1 activators in Agastache rugosa (Fisch. et Meyer) O. Kuntze (A.rugosa), commonly known as Korean mint to improve hTRPA1-related phenomena. An extract of the stem and leaves of A.rugosa (Labiatae) selectively activated hTRPA1 and hTRPV1. We next investigated the effects of commercially available compounds found in A.rugosa (acacetin, 4-allylanisole, p-anisaldehyde, apigenin 7-glucoside, L-carveol, β-caryophyllene, trans-p-methoxycinnamaldehyde, methyl eugenol, pachypodol, and rosmarinic acid) on cultured hTRPA1- and hTRPV1-expressing cells. Of the ten compounds, L-carveol, trans-p-methoxycinnamaldehyde, methyl eugenol, 4-allylanisole, and p-anisaldehyde selectively activated hTRPA1, with EC50 values of 189.1±26.8, 29.8±14.9, 160.2±21.9, 1535±315.7, and 546.5±73.0 μM, respectively. The activities of these compounds were effectively inhibited by the hTRPA1 antagonists, ruthenium red and HC-030031. Although the five active compounds showed weaker calcium responses than allyl isothiocyanate (EC50=7.2±1.4 μM), our results suggest that these compounds from the stem and leaves of A.rugosa are specific and selective agonists of hTRPA1.

  19. Chemical Contaminants Found in the Gastrointestinal Tract of Loggerhead Sea Turtles (Caretta caretta)

    Science.gov (United States)

    Athey, S. N.; Seaton, P. J.; Mead, R. N.

    2016-02-01

    Plastic is becoming increasingly more abundant in the marine environment. Plastic ingestion has been shown to be a source of exposure to a variety of harmful compounds, such as polycyclic aromatic hydrocarbons (PAHs), bisphenol A (BPA), and phthalates, which are known for their negative physiological effects on the endocrine system as well as their ability to adsorb and leach from plastic into the bodies of marine organisms. The physiological effects of these compounds on loggerhead sea turtles (Caretta caretta) still remain unknown. This study investigated the presence of toxicants on marine plastic samples collected from Bermuda, the Sargasso Sea, and the North Atlantic Ocean. Gas chromatography/triple quadruple mass spectrometry (GC/MS) analysis showed PAHs were present on many plastic debris samples. Plastic additives such as phthalates and (BPA) were also found. ΣPAH concentrations for anthracene, chrysene, benzo[b]fluoranthene, and benzo[k]fluoranthene for 2013 environmental plastic samples averaged 26.7ng/g of plastic. This study also examined the presence of these compounds in fluids from the stomach, small intestine, and large intestine from two adult loggerhead turtles. GC/MS analysis also showed the presence of BPA and phthalates on plastic samples, as well as in two out of the six gastrointestinal fluids samples. Average ΣPAH concentration for GI fluids for the loggerheads in the study was 58.7 ng/mL. This study showed plastic could be a significant source of PAHs in sea turtles and the first to detect PAHs in sea turtle GI fluid. Loggerhead sea turtles are a long living species and could accumulate high concentrations of these endocrine-disrupting chemicals throughout their lifetime.

  20. Types and Origins of Debris Found on Maui Shorelines: Implications for Mitigation Policies and Strategies

    Science.gov (United States)

    Blickley, L.; Currie, J. J.; Kaufman, G. D.

    2016-02-01

    Marine debris is an identified concern for coastal areas and is known to accumulate in large quantities in the North Pacific Ocean. The proximity of the Main Hawaiian Islands to these "garbage patches" represents an ongoing concern with little understanding of debris origins or efficacy of current mitigation policies. Debris accumulation surveys were conducted monthly between October 2013 and August 2014 and daily during January 2015 at 3 beaches on Maui's coastline. Debris accumulation rates, loads, and sources varied between sites and were influenced by both environmental and anthropogenic factors. Debris accumulation was strongly influenced by the temporal scale of sampling, with daily surveys showing a significant increase in accumulation rate. Plastics were the most common debris item at each site ranging from local, land-based debris including cigarette butts, straws, and food wrappers, to foreign, ocean-based debris such as oyster spacer tubes and hagfish traps. The results of this study indicate that the passage of a tobacco free beaches bill on Maui has not significantly reduced the amount of tobacco related debris. Alternatively, a ban on plastic grocery bags has eliminated this type of debris from Maui's shorelines, with no bags found at any of the sampling sites. The wide spread origins of collected debris further suggests that mitigation strategies to reduce debris will need to take place across hundreds of local municipalities. The efficacy of marine debris policies furthermore depends on enforcement and implementation strategy, as current results suggest policy enforcement at the producer level affords more effective results than that at the consumer level. Local debris mitigation actions have nevertheless been shown to affect debris loads, and municipalities are therefore encouraged to adopt a holistic combination of policy, community-based debris removal programs, increased public awareness, and ongoing monitoring to address marine debris.

  1. Long-term risk of acute diverticulitis among patients with incidental diverticulosis found during colonoscopy.

    Science.gov (United States)

    Shahedi, Kamyar; Fuller, Garth; Bolus, Roger; Cohen, Erica; Vu, Michelle; Shah, Rena; Agarwal, Nikhil; Kaneshiro, Marc; Atia, Mary; Sheen, Victoria; Kurzbard, Nicole; van Oijen, Martijn G H; Yen, Linnette; Hodgkins, Paul; Erder, M Haim; Spiegel, Brennan

    2013-12-01

    Colonic diverticulosis is the most common finding during routine colonoscopy, and patients often question the significance of these lesions. Guidelines state that these patients have a 10% to 25% lifetime risk of developing acute diverticulitis. However, this value was determined based on limited data, collected before population-based colonoscopy, so the true number of cases of diverticulosis was not known. We measured the long-term risk of acute diverticulitis among patients with confirmed diverticulosis discovered incidentally on colonoscopy. We performed a retrospective study using administrative and clinical data from the Veterans Affairs Greater Los Angeles Healthcare System, collecting data on patients who underwent colonoscopies from January 1996 through January 2011. We identified patients diagnosed with diverticulosis, determined incidence rates per 1000 patient-years, and analyzed a subgroup of patients with rigorously defined events confirmed by imaging or surgery. We used a Cox proportional hazards model to identify factors associated with the development of diverticulitis. We identified 2222 patients with baseline diverticulosis. Over an 11-year follow-up period, 95 patients developed diverticulitis (4.3%; 6 per 1000 patient-years); of these, 23 met the rigorous definition of diverticulitis (1%; 1.5 per 1000 patient-years). The median time-to-event was 7.1 years. Each additional decade of age at time of diagnosis reduced the risk for diverticulitis by 24% (hazard ratio, 0.76; 95% confidence interval, 0.6-0.9). Based on a study of the Veterans Affairs Greater Los Angeles Healthcare System, only about 4% of patients with diverticulosis develop acute diverticulitis, contradicting the common belief that diverticulosis has a high rate of progression. We also found that younger patients have a higher risk of diverticulitis, with risk increasing per year of life. These results can help inform patients with diverticulosis about their risk of developing acute

  2. Two Distinct Triatoma dimidiata (Latreille, 1811) Taxa Are Found in Sympatry in Guatemala and Mexico

    Science.gov (United States)

    Moguel, Barbara; Solorzano, Elizabeth; Dumonteil, Eric; Rodas, Antonieta; de la Rua, Nick; Garnica, Roberto; Monroy, Carlota

    2009-01-01

    Approximately 10 million people are infected with Trypanosoma cruzi, the causative agent of Chagas disease, which remains the most serious parasitic disease in the Americas. Most people are infected via triatomine vectors. Transmission has been largely halted in South America in areas with predominantly domestic vectors. However, one of the main Chagas vectors in Mesoamerica, Triatoma dimidiata, poses special challenges to control due to its diversity across its large geographic range (from Mexico into northern South America), and peridomestic and sylvatic populations that repopulate houses following pesticide treatment. Recent evidence suggests T. dimidiata may be a complex of species, perhaps including cryptic species; taxonomic ambiguity which confounds control. The nuclear sequence of the internal transcribed spacer 2 (ITS2) of the ribosomal DNA and the mitochondrial cytochrome b (mt cyt b) gene were used to analyze the taxonomy of T. dimidiata from southern Mexico throughout Central America. ITS2 sequence divides T. dimidiata into four taxa. The first three are found mostly localized to specific geographic regions with some overlap: (1) southern Mexico and Guatemala (Group 2); (2) Guatemala, Honduras, El Salvador, Nicaragua, and Costa Rica (Group 1A); (3) and Panama (Group 1B). We extend ITS2 Group 1A south into Costa Rica, Group 2 into southern Guatemala and show the first information on isolates in Belize, identifying Groups 2 and 3 in that country. The fourth group (Group 3), a potential cryptic species, is dispersed across parts of Mexico, Guatemala, and Belize. We show it exists in sympatry with other groups in Peten, Guatemala, and Yucatan, Mexico. Mitochondrial cyt b data supports this putative cryptic species in sympatry with others. However, unlike the clear distinction of the remaining groups by ITS2, the remaining groups are not separated by mt cyt b. This work contributes to an understanding of the taxonomy and population subdivision of T

  3. Awareness of Stem cells & Health Implications of SHED found in Pediatric Dentition among Indian Population.

    Science.gov (United States)

    Goomer, Pallvi; Sidhu, Arshpreet Kaur; Tuli, Preety; Kansal, Shinam; Bansal, Kanishka; Thakre, Gauri R

    2014-02-01

    Primary teeth may be an ideal source of postnatal stem cells to regenerate tooth structures and bone, and possibly to treat neural tissue injury or degenerative diseases. SHED (stem cells from human exfoliated deciduous teeth) were identified to be a population of highly proliferative, clonogenic cells capable of differentiating into a variety of cell types including neural cells, adipocytes, and odontoblasts. The present study was carried out to assess the knowledge, awareness & attitude of parents visiting various dental clinics in tricity area of india regarding stem cells from primary teeth and their potential health benefits. A total of 250 parents of pediatric patients seeking dental treatment at various dental clinics in tricity area were included in the study. Parents were personally interviewed with a questionnaire and their responses were immediately computed. Among 250 parents only 95(62%) had knowledge regarding stem cells. While only 47(18.8) were informed regarding stem cells from baby teeth & their benefits. Maximum subjects were informed through internet 21(44.6%) followed by information through friends(23.4%) and dentist(21.2%). Very few were informed through magazines, newspaper and only one (2.1%) person was informed by television. It is important to create more awareness among the populace of our country about the potential health benefits of stem cells from primary teeth. Dentist should educate parents, caregivers and teachers regarding SHED & its benefits, ensuring good health for every Indian child and hence health of future citizens. How to cite the article: Goomer P, Sidhu AK, Tuli P, Kansal S, Bansal K, Thakre GR. Awareness of Stem cells & Health Implications of SHED found in Pediatric Dentition among Indian Population. J Int Oral Health 2014;6(1):44-7.

  4. [90th anniversary of founding the first children's hospital in Serbia].

    Science.gov (United States)

    Mikić, Zelimir; Lesić, Aleksandar

    2009-01-01

    The first children's hospital in Serbia, as an exclusive paediatric intitution, was founded in a deserted military barrack in Studenieka Street, near the Military Hospital, in January 1919. The founder was Dr. Katherine MacPhail, a young Scottish lady doctor, who came to Serbia for the first time in January 1915, with the first "Scottish Women's Hospital". After that, she worked as a volunteer during the First World War in France and on the Thessalonica Front. In the spring of 1919, the hospital was given an open pavilion in Topcider, which worked only during the summer months till 1924. In November 1919, the hospital was moved to a new building in Knez Milos Street, and then named The Anglo-Serbian Children's Hospital. In February 1920, a new annex, called "Villa Bravacić", was opened in Dubrovnik, which was active till 1922. In this hospital, the first Training School for Serbian Nurses was opened in 1921, and in February of that year, the hospital moved into its new permanent house in Visegradska Street, where it had 70 beds, three wards with a modern operating theatre, outpatients' department, X-ray outfit and a pharmacy. Because of much better working conditions, the Children's Surgical Department of the General State Hospital headed by Dr. Dimitrije Jovcić, later a professor of the Faculty of Medicine in Belgrade, was accommodated in this hospital from 1923 to 1931. Apart from him, in this hospital, there used to work a number of young Serbian physicians and several of them later became professors of the Belgrade Faculty of Medicine. The hospital worked till 1934, when it was closed, the building was sold and from that money Dr. MacPhail built a new Anglo-Yugoslav Children's Hospital for Tuberculosis of Bones and Joints in Sremska Kamenica.

  5. Functional characterization of AVPR2 mutants found in Turkish patients with nephrogenic diabetes insipidus.

    Science.gov (United States)

    Erdem, Beril; Schulz, Angela; Saglar, Emel; Deniz, Ferhat; Schöneberg, Torsten; Mergen, Hatice

    2018-01-01

    Diabetes insipidus is a rare disorder characterized by an impairment in water balance because of the inability to concentrate urine. While central diabetes insipidus is caused by mutations in the AVP , the reason for genetically determined nephrogenic diabetes insipidus can be mutations in AQP2 or AVPR2 After release of AVP from posterior pituitary into blood stream, it binds to AVPR2, which is one of the receptors for AVP and is mainly expressed in principal cells of collecting ducts of kidney. Receptor activation increases cAMP levels in principal cells, resulting in the incorporation of AQP2 into the membrane, finally increasing water reabsorption. This pathway can be altered by mutations in AVPR2 causing nephrogenic diabetes insipidus. In this study, we functionally characterize four mutations (R68W, ΔR67-G69/G107W, V162A and T273M) in AVPR2, which were found in Turkish patients. Upon AVP stimulation, R68W, ΔR67-G69/G107W and T273M showed a significantly reduced maximum in cAMP response compared to wild-type receptor. All mutant receptor proteins were expressed at the protein level; however, R68W, ΔR67-G69/G107W and T273M were partially retained in the cellular interior. Immunofluorescence studies showed that these mutant receptors were trapped in ER and Golgi apparatus. The function of V162A was indistinguishable from the indicating other defects causing disease. The results are important for understanding the influence of mutations on receptor function and cellular trafficking. Therefore, characterization of these mutations provides useful information for further studies addressing treatment of intracellularly trapped receptors with cell-permeable antagonists to restore receptor function in patients with nephrogenic diabetes insipidus. © 2018 The authors.

  6. Kepler-424 b: A 'lonely' hot Jupiter that found A companion

    Energy Technology Data Exchange (ETDEWEB)

    Endl, Michael [McDonald Observatory, The University of Texas at Austin, Austin, TX 78712 (United States); Caldwell, Douglas A.; Barclay, Thomas; Huber, Daniel; Havel, Mathieu; Howell, Steve B.; Quintana, Elisa [NASA Ames Research Center, Moffett Field, CA 94035 (United States); Isaacson, Howard [Department of Astronomy, University of California, Berkeley, CA 94720 (United States); Buchhave, Lars A. [Harvard-Smithsonian Center for Astrophysics, Cambridge, MA 02138 (United States); Brugamyer, Erik [Department of Astronomy, The University of Texas at Austin, Austin, TX 78712 (United States); Robertson, Paul [Department of Astronomy and Astrophysics, Center for Exoplanets and Habitable Worlds, Pennsylvania State University (United States); Cochran, William D.; MacQueen, Phillip J. [McDonald Observatory and Department of Astronomy, The University of Texas at Austin, Austin, TX 78712 (United States); Lucas, Phillip [Centre for Astrophysics Research, University of Hertfordshire, College Lane, Hatfield AL10 9AB (United Kingdom); Fischer, Debra [Department of Astronomy, Yale University (United States); Ciardi, David R. [NASA Exoplanet Science Institute, California Institute of Technology, Pasadena, CA 91125 (United States)

    2014-11-10

    Hot Jupiter systems provide unique observational constraints for migration models in multiple systems and binaries. We report on the discovery of the Kepler-424 (KOI-214) two-planet system, which consists of a transiting hot Jupiter (Kepler-424b) in a 3.31 day orbit accompanied by a more massive outer companion in an eccentric (e = 0.3) 223 day orbit. The outer giant planet, Kepler-424c, is not detected transiting the host star. The masses of both planets and the orbital parameters for the second planet were determined using precise radial velocity (RV) measurements from the Hobby-Eberly Telescope (HET) and its High Resolution Spectrograph (HRS). In stark contrast to smaller planets, hot Jupiters are predominantly found to be lacking any nearby additional planets; they appear to be {sup l}onely{sup .} This might be a consequence of these systems having a highly dynamical past. The Kepler-424 planetary system has a hot Jupiter in a multiple system, similar to υ Andromedae. We also present our results for Kepler-422 (KOI-22), Kepler-77 (KOI-127), Kepler-43 (KOI-135), and Kepler-423 (KOI-183). These results are based on spectroscopic data collected with the Nordic Optical Telescope (NOT), the Keck 1 telescope, and HET. For all systems, we rule out false positives based on various follow-up observations, confirming the planetary nature of these companions. We performed a comparison with planetary evolutionary models which indicate that these five hot Jupiters have heavy element contents between 20 and 120 M {sub ⊕}.

  7. Processing German petroleum: (comparative tests of several oils found in Germany

    Energy Technology Data Exchange (ETDEWEB)

    Hupfer, H.; Leonhardt, P.; Kroenig, W.

    1943-02-05

    Topping residues from several German petroleum types were processed in a 10-liter oven at both 600 and 250 atm, using coke catalysts. Tables in the article gave the data comparisons. Tests on three types of petroleum (Wietze-heavy, Nienhagen, and Reitbrook) were conducted at 350/sup 0/ and 325/sup 0/C. Notable was the nearly complete decomposition of asphalt in most of the test runs. The best yields were obtained with the Wietze products, but the same conditions did not produce similar results with the other products. It was found that, as with bituminous coals, when lower pressure was used, the oil yield had a higher content of hydrogen; this was traced back to low reaction temperature since some processing tests for an oil yield were run at 325/sup 0/C instead of 350/sup 0/C. Tests using Reitbrook oil, with molybdenum-coke catalyst at this same temperature, resulted in a better yield. Octane numbers of gasoline made using iron catalyst were higher than those of gasoline made using molybdenum catalyst. None of the oils satisfied the specifications for fuel oil. Undiluted sludges from the oils were not filterable on technical scale. Composition of hydrocarbon vaporization was, in comparison to coal, lower in ethane, but higher in butane. Isobutane yield from processed petroleum appeared to be variable. In comparison to processing coal, the petroleum substances had to be preheated more strongly at 250 atm, nearly to the oven operating temperature. Also, coking was discovered. It was traced back to procedural problems. Nevertheless, there seemed to be no unsurmountable difficulties associated with hydrogenating the various petroleum types. 16 tables

  8. A new RNA virus found in black tiger shrimp Penaeus monodon from Thailand.

    Science.gov (United States)

    Sritunyalucksana, Kallaya; Apisawetakan, Somjai; Boon-Nat, Anutara; Withyachumnarnkul, Boonsirm; Flegel, Timothy W

    2006-06-01

    A new, apparently innocuous virus was found while investigating the cause of monodon slow growth syndrome (MSGS) in cultured black tiger shrimp (Penaeus monodon). It was identified via plasmid vector clones of E. coli containing randomly amplified cDNA fragments produced from total nucleic acid extracts of hemolymph from MSGS shrimp. Of 421 clones, 30 that failed to give positive dot blot hybridization with a digoxigenin (DIG)-labeled shrimp DNA probe were sequenced and compared to GenBank records. Of these, 22 corresponded to known shrimp DNA records. Of eight that did not, one (20A) showed significant deduced amino acid sequence similarity to RNA-dependent RNA polymerases (RdRp) of the viruses in the family Luteoviridae and alignment revealed commonly conserved amino acids including a GDD motif believed to be at the enzyme active site. However, phylogenetic analysis showed that the virus sequence did not cluster with the Luteoviridae or other known RNA virus sequences. Thus, in accordance with frequent practice, it was named according to the area where it was first collected as Laem-Singh virus (LSNV). In situ hybridization with a DIG-labeled 20A insert revealed strong cytoplasmic staining confined to the lymphoid organ (LO), the heart and hepatopancreatic connective tissue in both normal and MSGS shrimp. RT-PCR assays based on the 20A clone sequence also gave positive results with both normal and MSGS shrimp. Transmission electron microscopy (TEM) of LO tissue revealed viral-like particles of approximately 27 nm diameter (within the Luteoviridae size range) in locations that matched those of positive in situ hybridization reactions in parallel samples. Although not directly associated with MSGS in Penaeus monodon, the presence or effect of this virus with other crustacean species is presently unknown.

  9. Computational Transport Modeling of High-Energy Neutrons Found in the Space Environment

    Science.gov (United States)

    Cox, Brad; Theriot, Corey A.; Rohde, Larry H.; Wu, Honglu

    2012-01-01

    The high charge and high energy (HZE) particle radiation environment in space interacts with spacecraft materials and the human body to create a population of neutrons encompassing a broad kinetic energy spectrum. As an HZE ion penetrates matter, there is an increasing chance of fragmentation as penetration depth increases. When an ion fragments, secondary neutrons are released with velocities up to that of the primary ion, giving some neutrons very long penetration ranges. These secondary neutrons have a high relative biological effectiveness, are difficult to effectively shield, and can cause more biological damage than the primary ions in some scenarios. Ground-based irradiation experiments that simulate the space radiation environment must account for this spectrum of neutrons. Using the Particle and Heavy Ion Transport Code System (PHITS), it is possible to simulate a neutron environment that is characteristic of that found in spaceflight. Considering neutron dosimetry, the focus lies on the broad spectrum of recoil protons that are produced in biological targets. In a biological target, dose at a certain penetration depth is primarily dependent upon recoil proton tracks. The PHITS code can be used to simulate a broad-energy neutron spectrum traversing biological targets, and it account for the recoil particle population. This project focuses on modeling a neutron beamline irradiation scenario for determining dose at increasing depth in water targets. Energy-deposition events and particle fluence can be simulated by establishing cross-sectional scoring routines at different depths in a target. This type of model is useful for correlating theoretical data with actual beamline radiobiology experiments. Other work exposed human fibroblast cells to a high-energy neutron source to study micronuclei induction in cells at increasing depth behind water shielding. Those findings provide supporting data describing dose vs. depth across a water-equivalent medium. This

  10. Freshwater rotifers from Hordaland, western Norway, with a survey of freshwater rotifers previously found in Norway

    Directory of Open Access Journals (Sweden)

    Brit Godske Bjørklund

    2010-01-01

    Full Text Available   Bjørklund BG. 2009. Freshwater rotifers from Hordaland western Norway with a u survey of freshwater rotifers previously found in Norway. Fauna Norvegica29: 11-54. A total of 156 species (or subspecies o rotifers, mostly non-planktonic, have been identified from freshwater or slightly brackish-water localities in the county of Hordaland; 83 are new to Norway and 24 others are new to the county. One hundred of the species were collected from the two valleys of Eksingedalen and Teigdalen in spring and summer 1967. Samples were taken on the shallow shores of lake-like parts of the rivers, and in pools, tarns and small lakes. Forty more or less euryhaline fresh­water rotifers were also collected during studies of slightly brackish-water localities around Bergen in 1963-1969. A number of freshwater rotifers were collected at several localities in and around Bergen in 1968-1970, and on the western part of Hardangervidda. Of those so far identified ,23 are new to Norway and 8 more are new to the county. They are therefore included in the species list. A few additional ones are referred to in the taxonomical notes. All the species are listed with localities and habitat categories, or, in the case of the last-mentioned ones, just the district where they were collected. The paper includes notes, measurements and ,in most cases, figures regarding 44 little known, variable or taxonomically problematical species, especially in the genera Cephalodella and Trichocerca. Comments are given on the distribution , abundance and diversity of the species. The paper presents asurvey of previous investigations on rotifers in Norway, listing 200 previously recorded freshwater (a few euryhaline rotifers, giving other names, the authors who recorded the finds and, in most cases, the counties where the species were collected. 

  11. Potential hazards of toxic metals found in toothpastes commonly used in Nigeria.

    Science.gov (United States)

    Orisakwe, Orish Ebere; Okolo, Kenneth Obinna; Igweze, Zelinjo Nkeiruka; Ajaezi, Godwin Chukwuebuka; Udowelle, Nnaemeka Arinze

    2016-01-01

    Toothpastes have multi-functional configurations as oral care products. They can however constitute a pos- sible source, amongst others, of toxic metal exposure in public health. Indeed, the public health impact of personal hygiene and consumer products is largely unknown. To determine the level of toxic metals (lead, cadmium, cobalt, chromium, nickel) in toothpastes available in Nigeria, (home produced and imported), and assess the potential risk to the people. The samples of toothpastes commonly used in Nigeria were tested. Using a market basket protocol thirty five different brands of toothpaste were used. Samples were digest by addition of 10 mL mixture of conc. nitric and hydrochloric acids (HCl:HNO(3), 3:1), followed by heating to dryness. 20 mL deionized water was added, stirred and filtered. The filtrate was made up in standard volumetric flask and lead, cadmium, chromium, cobalt and nickel concentrations were determined using the atomic absorption spectrophotometry 205A. The daily intake of metals and target hazard quotient (THQ) were then calculated. Pepsodent and Flodent had the highest levels of lead at respectively 23.575 and 18.092 mg/kg while Colgate Herbal had the highest nickel of 18.535 mg/kg. The daily intake estimates of all imported toothpaste samples were below the stated upper limits (UL). All target hazard quotients were also found to be below one. Although the UL, THQ and daily intake rates were all normal, the high levels of lead in some of the tooth- pastes an important concern to public health suggesting that pre-marketing safety studies of toothpastes may be worthwhile for the regulatory authorities.

  12. Human metapneumovirus found in clinical materials of children with respiratory tract diseases

    Directory of Open Access Journals (Sweden)

    Katarina Logar

    2006-10-01

    Full Text Available Background: Human metapneumovirus (hMPV was first recognized in the Netherlands in 2001. Since then, it has been documented all over the world as a cause of human respiratory infections in all age groups. The objective of this study was to introduce and optimize an assay for detecting hMPV in clinical material of our patients. To date, there has not been a report that describes the detection of this virus in Slovenia.Methods: A total of 58 specimens, randomly collected during 2003/2004 from the patients ≤ 19 years old with respiratory disease and 20 specimens collected in 1997 were tested for hMPV. Extraction of RNA from frozen specimens and subsequent single-step reverse transcription-polymerase chain reaction (RT-PCR were performed. Human metapneumovirus amplicons were determined by electrophoresis in a 2 % (w/v agarose gel.Results: Human metapneumovirus was detected in 13/58 (22 % specimens; 10/40 (25 % specimens were from the upper and 3/18 (17 % from the lower respiratory tract. The mean age of infected patients was 3.2 ± 2.2 years. Out of 13 of the hMPV-positive specimens, 9 were positive also for another respiratory virus. Two of 20 (10 % archival specimens were hMPV-positive.Conclusions: This study is the first report about hMPV in Slovenia. Human metapneumovirus was detected as the second most frequent virus after RSV in children < 3 years of age. The virus was not found in the specimens from the children younger than 2 months. Based on the hMPV-positive results in archival clinical material, it is suggested that hMPV had circulated in Slovenia before the time it was discovered.

  13. Effects of three major amino acids found in Japanese broth on glucose metabolism and gastric emptying.

    Science.gov (United States)

    Mano, Fumika; Ikeda, Kaori; Joo, Erina; Yamane, Shunsuke; Harada, Norio; Inagaki, Nobuya

    2017-08-10

    To our knowledge, the effect of the broth of dried kelp and dried bonito, dashi, on glucose metabolism and digestion has rarely been studied. Based on the component analysis of three actual broths served in traditional restaurants, a chemically synthesized broth with three free amino acids (histidine, glutamate, aspartate) and salt was prepared to investigate their effect on glucose metabolism, glucose-dependent insulinotropic polypeptide (GIP), and glucagon-like peptide 1 (GLP-1) secretion, and digestion. In study 1, seven healthy individuals were enrolled in a four-period crossover study. Participants drank or ate hot water, synthesized broth, hot water with rice, and synthesized broth with rice. Plasma glucose, serum insulin, plasma glucagon, plasma GIP, and plasma GLP-1 were measured at baseline and after ingestion. In study 2, 6 of the 7 individuals ingested rice steamed with (13)C-labeled sodium acetate with hot water or synthesized broth to estimate gastric emptying by the (13)C-labeled acetate breath test in a two-period crossover trial. Ingesting water or synthesized broth alone elicited no change in plasma glucose or serum insulin levels. Ingesting synthesized broth with rice resulted in a rapid rise in plasma glucose and GLP-1 (P = 0.01 and 0.02, respectively) in an early postprandial phase compared with that by ingesting water with rice, but the area under the curve of those showed no significant differences. Ingesting synthesized broth with rice resulted in a significantly higher gastric emptying coefficient than that after rice with water (P = 0.03). Three amino acids and sodium chloride corresponding to those found in actual broth promoted gastric emptying and led to a rapid response of plasma glucose. Our findings suggest that ingestion of the broth of dried kelp and dried bonito may improve gastric motility. Copyright © 2017 Elsevier Inc. All rights reserved.

  14. Mite diversity on plants of different families found in the Brazilian Atlantic Forest

    Energy Technology Data Exchange (ETDEWEB)

    Castro, Tatiane M.M.G. de [UNESP, Jaboticabal, SP (Brazil). Faculdade de Ciencias Agrarias e Veterinarias. Dept. de Fitossanidade]. E-mail: tatianemarie@yahoo.com.br; Moraes, Gilberto J. de [Universidade de Sao Paulo (USP), Piracicaba, SP (Brazil). Escola Superior de Agricultura Luiz de Queiroz (ESALQ). Dept. Entomologia, Fitopatologia e Zoologia Agricola]. E-mail: gjmoraes@esalq.usp.br

    2007-09-15

    This work reports the occurrence of mites predominantly predatory, phytophagous and with varied feeding habits on plants of the Atlantic Forest vegetation type of the State of Sao Paulo. The objective was to estimate the possible role of the Atlantic Forest vegetation as reservoir of these groups of mites which are also found on plants of agricultural importance. Samples were taken from 187 plant species belonging to 73 families in three vegetation types of the Atlantic Forest from February of 2001 to October of 2002. A total of 2,887 mites belonging to 163 morpho-species of 16 families were collected. Mite diversity was high, especially of predatory mites; these corresponded to 1,562 specimens of 92 morpho-species. Within this group, Phytoseiidae comprised 71% of the specimens and 62% of the morpho-species. Phytophagous mites comprised 836 specimens of 36 morpho-species. Within this group, Tenuipalpidae comprised the larger proportion of specimens (61%) whereas Tetranychidae corresponded to the larger proportion of morpho-species (64%). Mites with varied feeding habits corresponded to 491 specimens of 36 morpho-species. In this group, the larger proportion of specimens (52%) consisted of Ascidae and the larger proportion of morpho-species (42%) consisted of Tydeinae (family Tydeidae). High abundance and high morpho-species richness of mites of predominantly predatory, phytophagous and variable feeding habits were observed on 17, five and nine plant species, respectively. The results obtained suggest the importance of plants of the studied vegetation as reservoirs of predatory mites. (author)

  15. Precise time-window for the onset of glacial termination found

    Science.gov (United States)

    Lai, C.-C.; Tseng, Y.-H.; Dietrich, D. E.

    2009-04-01

    Following a set of three simple rules, we have found a precise time-window (TW) for each onset of a glacial termination (GT) appeared during the last million years. The onset of GT (OGT) is defined as the year when the following two conditions are met: (1) the benthic delta 18-O is a maximum and greater than 4.5‰ and (2) its value continually drops 1‰ within 5 Ky. We developed the rules based on three hypotheses. We hypothesize that: (H1) The Earth's three orbital parameters (eccentricity, obliquity and precession of equinox) determine the insolation which is the key force to the climate system. (H2) However, only a small fraction of insolation is converted into sensible heat (SH) and chemical energy through photosynthesis (CETP) as influxes to the climate system's main heat capacitors (HCs), namely the world oceans. When insolation increases, both the SH flux and CETP increase. The downward SH flux will only increase the stability of the seawater. Nonetheless, the CETP gets accumulated faster than average. The CETP cascades through the marine food web and bacterial degradation. Finally, it is stored in the simple gas molecules (such as CH4) that form methane hydrate (MH) and other hydrates such as hydrogen sulfide hydrate (HSH) in deep sea sediments after a long time. While hydrates deposit accumulates with time, it also breaks off from the sediments from time to time. Since the density of MH is slightly smaller than average seawater, the MH ascends slowly from deep sea into upper part of ocean. But, HSH is slightly denser than the warm seawater in the upper part of ocean. Over the portion of glacial cycle when insolation is strong, the existence of a residual SH prevents the ascension of hydrates. (H3) Internal forcing - An internal energy converter or a heat generator exists in the oceans. Lai (2007) has found the link between the observed seawater warming at intermediate depth (400 - 750 m) (Barnett et al. 2001) and the dissociation of floating microscopic

  16. Measuring the Discharge of River Flood Using Witnesses Movies Found on the Internet

    Science.gov (United States)

    Hauet, A.; Le Coz, J.; Le Boursicaud, R.; Pénard, L.

    2014-12-01

    The knowledge of the discharge of river during extreme flood is of prime importance for the scientific and the research community. Unfortunately, measuring discharge using conventional methods is impossible because the high velocities and the floating debris endanger the operators and the equipment. The typical time-scale for gauging does not match up to the time scale of the dynamic of extreme flood. Finally, floods are mesoscale events that affect generally several watersheds at the same time, and gauging teams do not have the capabilities for covering the whole region of interest. Recently, non intrusive method for measuring discharge have been developed and tested in flood conditions. Doppler surface velocity radar and Large Scale Particle Image Velocimetry (LSPIV) showed their efficiency for measuring discharge during extreme events, but those methods need to be deployed by operators and the problems of time-scale and space-scale covering aforementioned are not solved. In this study, authors present how flood discharge measurement can benefits from the huge development, the last 10 years, of internet and of the on-line sharing of files. Floods are impressive phenomena, and hundreds of witnesses movies can be found on the internet after every important event. The different steps in order to apply LSPIV analysis to witness movie are detailed: (i) selection of the video of interest; (ii) contact with the author of the video; (iii) preparing the video for the LSPIV analysis : stabilization of the images, field campaigns; (iv) LSPIV analysis, providing surface velocity field; and (v)discharge computation. A case study on the major flash flood of 18 June 2013 of the Gave River at Cauterets, French Pyrennees, is presented. Results show that witnesses movies can bring useful information and allow estimating discharges values. Capabilities and limitations of LSPIV applied to witnesses movies are detailed. Finally, the paper presents an approach conducted within the

  17. Analyzing Raman - Infrared spectral correlation in the recently found meteorite Csátalja

    Science.gov (United States)

    Kereszturi, A.; Gyollai, I.; Kereszty, Zs.; Kiss, K.; Szabó, M.; Szalai, Z.; Ringer, M.; Veres, M.

    2017-02-01

    Correlating the Raman and infrared spectra of shocked minerals in Csátalja ordinary chondrite (H4, S2, W2) with controlling the composition by EPMA measurements, we identified and improved various shock indicators, as infrared spectro-microscopic analysis has been poorly used for shock impact alteration studies of meteorites to date. We also provide reference spectra as SOM for the community with local mineralogical and shock alteration related context to support further standardization of the IR ATR based measurements. Raman band positions shifted in conjunction with the increase in full width half maximum (FWHM) with shock stage in olivine minerals while in the infrared spectra when comparing the IR band positions and IR maximal absorbance, increasing correlation was found as a function of increasing shock effects. This is the first observational confirmation with the ATR method of the already expected shock related disordering. In the case of shocked pyroxenes the well-known peak broadening and peak shift was confirmed by Raman method, beyond the level that could have been produced by only chemical changes. With increasing shock level the 852-864 cm- 1 and 1055-1071 cm- 1 FTIR bands finally disappeared. From the shock effect occasionally mixed mineral structures formed, especially feldspars together with pyroxene. Feldspars were only present in the shock melted volumes, thus produced by the shock effect itself. Based on the above mentioned observations in Csátalja meteorite the less shocked (only fractured) part witnessed 2-6 GPa shock pressure with temperature below 100 °C. The moderately shocked parts (minerals with mosaicism and mechanical twins) witnessed 5-10 GPa pressure and 900 °C temperature. The strongly shocked area (many olivine and pyroxene grains) was subject to 10-15 GPa and 1000 °C. The existence of broad peak near 510 cm- 1 and disappearance of other peaks of feldspar at 480 and 570 cm- 1 indicate the presence of maskelynite, which proposes

  18. Common Genetic Variants Found in HLA and KIR Immune Genes in Autism Spectrum Disorder.

    Science.gov (United States)

    Torres, Anthony R; Sweeten, Thayne L; Johnson, Randall C; Odell, Dennis; Westover, Jonna B; Bray-Ward, Patricia; Ward, David C; Davies, Christopher J; Thomas, Aaron J; Croen, Lisa A; Benson, Michael

    2016-01-01

    The "common variant-common disease" hypothesis was proposed to explain diseases with strong inheritance. This model suggests that a genetic disease is the result of the combination of several common genetic variants. Common genetic variants are described as a 5% frequency differential between diseased vs. matched control populations. This theory was recently supported by an epidemiology paper stating that about 50% of genetic risk for autism resides in common variants. However, rare variants, rather than common variants, have been found in numerous genome wide genetic studies and many have concluded that the "common variant-common disease" hypothesis is incorrect. One interpretation is that rare variants are major contributors to genetic diseases and autism involves the interaction of many rare variants, especially in the brain. It is obvious there is much yet to be learned about autism genetics. Evidence has been mounting over the years indicating immune involvement in autism, particularly the HLA genes on chromosome 6 and KIR genes on chromosome 19. These two large multigene complexes have important immune functions and have been shown to interact to eliminate unwanted virally infected and malignant cells. HLA proteins have important functions in antigen presentation in adaptive immunity and specific epitopes on HLA class I proteins act as cognate ligands for KIR receptors in innate immunity. Data suggests that HLA alleles and KIR activating genes/haplotypes are common variants in different autism populations. For example, class I allele (HLA-A2 and HLA-G 14 bp-indel) frequencies are significantly increased by more than 5% over control populations (Table 2). The HLA-DR4 Class II and shared epitope frequencies are significantly above the control populations (Table 2). Three activating KIR genes: 3DS1, 2DS1, and 2DS2 have increased frequencies of 15, 22, and 14% in autism populations, respectively. There is a 6% increase in total activating KIR genes in autism over

  19. Towards a well-founded and reproducible snow load map for Austria

    Science.gov (United States)

    Winkler, Michael; Schellander, Harald

    2017-04-01

    "EN 1991-1-3 Eurocode 1: Part 1-3: Snow Loads" provides standard for the determination of the snow load to be used for the structural design of buildings etc. Since 2006 national specifications for Austria define a snow load map with four "load zones", allowing the calculation of the characteristic ground snow load sk for locations below 1500 m asl. A quadratic regression between altitude and sk is used, as suggested by EN 1991-1-3. The actual snow load map is based on best meteorological practice, but still it is somewhat subjective and non-reproducible. Underlying snow data series often end in the 1980s; in the best case data until about 2005 is used. Moreover, extreme value statistics only rely on the Gumbel distribution and the way in which snow depths are converted to snow loads is generally unknown. This might be enough reasons to rethink the snow load standard for Austria, all the more since today's situation is different to what it was some 15 years ago: Firstly, Austria is rich of multi-decadal, high quality snow depth measurements. These data are not well represented in the actual standard. Secondly, semi-empirical snow models allow sufficiently precise calculations of snow water equivalents and snow loads from snow depth measurements without the need of other parameters like temperature etc. which often are not available at the snow measurement sites. With the help of these tools, modelling of daily snow load series from daily snow depth measurements is possible. Finally, extreme value statistics nowadays offers convincing methods to calculate snow depths and loads with a return period of 50 years, which is the base of sk, and allows reproducible spatial extrapolation. The project introduced here will investigate these issues in order to update the Austrian snow load standard by providing a well-founded and reproducible snow load map for Austria. Not least, we seek for contact with standards bodies of neighboring countries to find intersections as well

  20. Extensive horizontal transfer of core genome genes between two Lactobacillus species found in the gastrointestinal tract

    Directory of Open Access Journals (Sweden)

    Maguin Emmanuelle

    2007-08-01

    Full Text Available Abstract Background While genes that are conserved between related bacterial species are usually thought to have evolved along with the species, phylogenetic trees reconstructed for individual genes may contradict this picture and indicate horizontal gene transfer. Individual trees are often not resolved with high confidence, however, and in that case alternative trees are generally not considered as contradicting the species tree, although not confirming it either. Here we conduct an in-depth analysis of 401 protein phylogenetic trees inferred with varying levels of confidence for three lactobacilli from the acidophilus complex. At present the relationship between these bacteria, isolated from environments as diverse as the gastrointestinal tract (Lactobacillus acidophilus and Lactobacillus johnsonii and yogurt (Lactobacillus delbrueckii ssp. bulgaricus, is ambiguous due to contradictory phenotypical and 16S rRNA based classifications. Results Among the 401 phylogenetic trees, those that could be reconstructed with high confidence support the 16S-rRNA tree or one alternative topology in an astonishing 3:2 ratio, while the third possible topology is practically absent. Lowering the confidence threshold for trees to be taken into consideration does not significantly affect this ratio, and therefore suggests that gene transfer may have affected as much as 40% of the core genome genes. Gene function bias suggests that the 16S rRNA phylogeny of the acidophilus complex, which indicates that L. acidophilus and L. delbrueckii ssp. bulgaricus are the closest related of these three species, is correct. A novel approach of comparison of interspecies protein divergence data employed in this study allowed to determine that gene transfer most likely took place between the lineages of the two species found in the gastrointestinal tract. Conclusion This case-study reports an unprecedented level of phylogenetic incongruence, presumably resulting from extensive

  1. Common Genetic Variants Found in HLA and KIR Immune Genes in Autism Spectrum Disorder

    Directory of Open Access Journals (Sweden)

    Anthony R Torres

    2016-10-01

    Full Text Available The common variant - common disease hypothesis was proposed to explain diseases with strong inheritance. This model suggests that a genetic disease is the result of the combination of several common genetic variants. Common genetic variants are described as a 5% frequency differential between diseased versus matched control populations. This theory was recently supported by an epidemiology paper stating that about 50% of genetic risk for autism resides in common variants. However, rare variants, rather than common variants, have been found in numerous genome wide genetic studies and many have concluded that the common variant—common disease hypothesis is incorrect. One interpretation is that rare variants are major contributors to genetic diseases and autism involves the interaction of many rare variants, especially in the brain. It is obvious there is much yet to be learned about autism genetics.Evidence has been mounting over the years indicating immune involvement in autism, particularly the HLA genes on chromosome 6 and KIR genes on chromosome 19. These two large multigene complexes have important immune functions and have been shown to interact to eliminate unwanted virally infected and malignant cells. HLA proteins have important functions in antigen presentation in adaptive immunity and specific epitopes on HLA class I proteins act as cognate ligands for KIR receptors in innate immunity. Data suggests that HLA alleles and KIR activating genes/haplotypes are common variants in different autism populations. For example, class I allele (HLA-A2 and HLA-G 14bp-indel frequencies are significantly increased by more than 5% over control populations (Table2. The HLA-DR4 Class II and shared epitope frequencies are significantly above the control populations (Table 2. Three activating KIR genes: 3DS1, 2DS1 and 2DS2 have increased frequencies of 15%, 22% and 14% in autism populations, respectively. There is a 6% increase in total activating KIR

  2. Mysterious inhibitory cell regulator investigated and found likely to be secretogranin II related

    Directory of Open Access Journals (Sweden)

    John E. Hart

    2017-10-01

    Full Text Available In the context of a hunt for a postulated hormone that is tissue-mass inhibiting and reproductively associated, there is described probable relatedness to a granin protein. A 7–8 kDa polypeptide candidate (gels/MS appeared in a bioassay-guided fractionation campaign involving sheep plasma. An N-terminal sequence of 14 amino acids was obtained for the polypeptide by Edman degradation. Bioinformatics and molecular biology failed to illuminate any ovine or non-ovine protein which might relate to this sequence. The N-terminal sequence was synthesized as the 14mer EPL001 peptide and surprisingly found to be inhibitory in an assay in vivo of compensatory renal growth in the rat and modulatory of nematode fecundity, in line with the inhibitory hormone hypothesis. Antibodies were raised to EPL001 and their deployment upheld the hypothesis that the EPL001 amino acid sequence is meaningful and relevant, notwithstanding bioinformatic obscurity. Immunohistochemistry (IHC in sheep, rodents and humans yielded staining of seeming endocrine relevance (e.g. hypothalamus, gonads and neuroendocrine cells in diverse tissues, with apparent upregulation in certain human tumours (e.g. pheochromocytoma. Discrete IHC staining in Drosophila melanogaster embryo brain was seen in glia and in neuroendocrine cells, with staining likely in the corpus cardiacum. The search for the endogenous antigen involved immunoprecipitation (IP followed by liquid chromatography and mass spectrometry (LC–MS. Feedstocks were PC12 conditioned medium and aqueous extract of rat hypothalamus—both of which had anti-proliferative and pro-apoptotic effects in an assay in vitro involving rat bone marrow cells, which inhibition was subject to prior immunodepletion with an anti-EPL001 antibody—together with fruit fly embryo material. It is concluded that the mammalian antigen is likely secretogranin II (SgII related. The originally seen 7–8 kDa polypeptide is suggested to be a new proteoform

  3. Urodele p53 tolerates amino acid changes found in p53 variants linked to human cancer

    Directory of Open Access Journals (Sweden)

    Villiard Éric

    2007-09-01

    Full Text Available Abstract Background Urodele amphibians like the axolotl are unique among vertebrates in their ability to regenerate and their resistance to develop cancers. It is unknown whether these traits are linked at the molecular level. Results Blocking p53 signaling in axolotls using the p53 inhibitor, pifithrin-α, inhibited limb regeneration and the expression of p53 target genes such as Mdm2 and Gadd45, suggesting a link between tumor suppression and regeneration. To understand this relationship we cloned the p53 gene from axolotl. When comparing its sequence with p53 from other organisms, and more specifically human we observed multiple amino acids changes found in human tumors. Phylogenetic analysis of p53 protein sequences from various species is in general agreement with standard vertebrate phylogeny; however, both mice-like rodents and teleost fishes are fast evolving. This leads to long branch attraction resulting in an artefactual basal emergence of these groups in the phylogenetic tree. It is tempting to assume a correlation between certain life style traits (e.g. lifespan and the evolutionary rate of the corresponding p53 sequences. Functional assays of the axolotl p53 in human or axolotl cells using p53 promoter reporters demonstrated a temperature sensitivity (ts, which was further confirmed by performing colony assays at 37°C. In addition, axolotl p53 was capable of efficient transactivation at the Hmd2 promoter but has moderate activity at the p21 promoter. Endogenous axolotl p53 was activated following UV irradiation (100 j/m2 or treatment with an alkylating agent as measured using serine 15 phosphorylation and the expression of the endogenous p53 target Gadd45. Conclusion Urodele p53 may play a role in regeneration and has evolved to contain multiple amino acid changes predicted to render the human protein defective in tumor suppression. Some of these mutations were probably selected to maintain p53 activity at low temperature. However

  4. Radial Clearance Found To Play a Key Role in the Performance of Compliant Foil Air Bearings

    Science.gov (United States)

    Radil, Kevin C.

    2003-01-01

    Compliant foil air bearings are at the forefront of the Oil-Free turbomachinery revolution, which supports gas turbine engines with hydrodynamic bearings that use air instead of oil as the working fluid. These types of bearings have been around for almost 50 years and have found a home in several commercial applications, such as in air cycle machines, turbocompressors, and microturbines, but are now being aggressively pursued for use in small and midrange aircraft gas turbine engines. Benefits include higher operating speeds and temperatures, lower maintenance costs, and greater reliability. The Oil-Free Turbomachinery team at the NASA Glenn Research Center is working to foster the transition of Oil-Free technology into gas turbine engines by performing in-house experiments on foil air bearings in order to gain a greater insight into their complex operating principles. A research program recently undertaken at Glenn focused on the concept of radial clearance and its influence on bearing performance. The tests were conducted on foil bearings with different radial clearances. As defined for a foil bearing, radial clearance is a measure of the small amount of shaft radial motion that is present from play that exists in the elastic support structure, such as between the top and bump foils and the bump foils and bearing shell (see the drawing). With an insufficient amount of radial clearance, the bearing imparts a high preload on the shaft, which when excessive, can reduce the loadcarrying capability of the bearing. On the other hand, systems using foil bearings with excessive radial clearance may experience rotordynamic instabilities because of low bearing preload. Therefore, without a more thorough understanding of radial clearance, it is difficult to accurately predict the performance of a given bearing design. The test program demonstrated that there is a direct correlation between radial clearance and the performance of foil air bearings. As shown in the graph, an

  5. Experimental investigation of pressure responsive 'smart' materials found in the natural world

    Science.gov (United States)

    Greene, George W.

    The unique ability to sense environmental stimuli and respond appropriately in a controlled and reversible fashion is a distinguishing characteristic of a novel class of materials collectively known as 'smart,' 'adaptive,' or 'responsive' materials. This seemingly 'smart' behavior is, thus, controlled by internal 'feedback loops' generated by the interconnectivity of various system elements which enables them to operate cooperatively and exhibit more complex behaviors as a collective. This thesis investigates, experimentally, three natural systems found in both the biological and non-biological domains which exhibit responsive or adaptive behaviors in the presence of external mechanical pressures by exploiting uniquely different chemical and physical principles. The first system focuses on articular cartilage, an example of an adaptive material which utilizes its distinctive hierachical, multi-scale structure in order to adjust and change its physical and lubricating properties to suit the specific needs under a broad range of normal and shear stresses. A compression cell designed to fit inside an NMR spectrometer was used to investigate the in situ mechanical strain response, structural changes to the internal pore structure, and the diffusion and flow of interstitial water in full thickness cartilage samples as it was deforming dynamically under a constant compressive load (pressure). We distinguish between the hydrostatic pressure acting on the interstitial fluid and the pore pressure acting on the cartilage fibril network. Our results show that properties related to the pore matrix microstructure such as diffusion and hydraulic conductivity are strongly influenced by the hydrostatic pressure in the interstitial fluid of the dynamically deforming cartilage which differ significantly from the properties measured under static i.e. equilibrium loading conditions (when the hydrostatic pressure has relaxed back to zero). The magnitude of the hydrostatic fluid

  6. Lost Body, found Body

    Directory of Open Access Journals (Sweden)

    Marcela Arpes

    2008-01-01

    Full Text Available La intención del presente trabajo es la de examinar qué tipo de apropiaciones y puesta en circulación realiza el arte, específicamente el teatro, de las diversas representaciones sociales del cuerpo. Nos detendremos en varios textos dramáticos del ciclo que ya lleva seis años de edición conocido en la Argentina como Teatro por la Identidad. Teatro por la Identidad es una propuesta estética surgida de la Asociación Abuelas de Plaza de Mayo con el fin de recuperar las identidades, aún no recobradas, de los hijos apropiados durante la dictadura militar de 1976. El teatro se presenta entonces como la alternativa estética y política privilegiada para inquietar e inquirir sobre las identidades de cada uno de los que asisten a las representaciones. El cuerpo adquiere un espacio de densa significación en esta propuesta teatral ya que la ficción hace presentes los cuerpos “desaparecidos” del pasado encarnándolos en los “cuerpos sin órganos”, corporeidades en grado cero de los “hijos” arrebatados, para restituirles la identidad perdida. El planteo teórico excede en mucho el trabajo sobre la noción de individualidad, ya que el cuerpo se presenta como medio de conocimiento histórico y social al articular cuerpo individual y cuerpo social en una lógica de implicancia necesaria.

  7. The key found

    Directory of Open Access Journals (Sweden)

    Agata Stankowka

    2010-01-01

    Full Text Available Poetycka antropologia Julii Hartwig [Julia Hartwig’s poetic anthropology] written by Marcin Terlecki is a book that fills the yawning gap in our literary understanding of the twentieth century Polish poetry and constitutes the first attempt at a comprehensive and detailed presentation of the lyrical works by J. Hartwig. The modern collection in which the work appears allow M. Terlecki to reveal the poetess’ fundamental insights dominating and underlying her world outlook and epistemological views. This, in turn, puts him in a position to give an explanation to the logic embedded in the evolution under scrutiny. M. Terlecki convincingly supports his own argument concerning J. Hartwig’s poetic reception of the world proving the thesis that its fundamentals are deeply rooted in the anthropological perspective. Terlecki differentiates the latter into three basic categories. First, there is “strangeness/alienation”, which results in the need for self-definition (determination of one’s nature and basic qualities. Then, “identity”, whose reflection turns out to be not only what is different in its external shape, but also what is different inside — within the plane of one’s own culture, biography and personality. And, finally, “empathy”, born out of questions on a feasibility of contact with what is different, alien and absent. The three categories, connected by the logic of anthropological vision, are presented as basic and fundamental for the subsequent stages in Hartwig’s poetical output. At the same time, they reveal themselves as axes of anthropological reading material provided by the author — for the discussed book is the author’s own research project on “poetic anthropology”.

  8. Yesterday I Found...

    Science.gov (United States)

    Paull, Dorothy; Paull, John

    This booklet describes an elementary school program at Anstey Latimer Primary School in Leicestershire, England, that used the natural environment as the focus for its studies. Students were 7 to eleven years old, and each class had two or three ages grouped together. Students were allowed to pursue whatever projects interested them. The projects…

  9. Found in Translation

    Science.gov (United States)

    Carrol, Gareth; Conklin, Kathy; Gyllstad, Henrik

    2016-01-01

    Formulaic language represents a challenge to even the most proficient of language learners. Evidence is mixed as to whether native and nonnative speakers process it in a fundamentally different way, whether exposure can lead to more nativelike processing for nonnatives, and how L1 knowledge is used to aid comprehension. In this study we…

  10. Teaching America's Founding Documents.

    Science.gov (United States)

    Tucker, James

    1993-01-01

    Reflects on the author's experiences teaching a course on great documents in American history to high school students, concentrating on teaching the Declaration of Independence and the "Federalist Papers." Countering the students' tendencies toward superficial reading and encouraging deep analysis are the teacher's primary goals. (SLD)

  11. Found in translation

    DEFF Research Database (Denmark)

    Tietjen, Anne

    2017-01-01

    on a teaching experiment in landscape architecture education, this paper proposes teaching creative site analysis as a translation process of observed site conditions into desirable future site conditions. Guided by actor-network theory, the paper outlines, first, a conceptual framework for creative site...... for the students. Overall, the produced design work and the student evaluations show that translation offers an operational framework for teaching a creative approach to site analysis....

  12. Organizational Growth: Linking Founding Team, Strategy, Environment, and Growth among U.S. Semiconductor Ventures, 1978-1988.

    Science.gov (United States)

    Eisenhardt, Kathleen M.; Schoonhoven, Claudia Bird

    1990-01-01

    Summarizes a study exploring organizational growth in technology-based ventures. Characteristics of the founding top-management team, strategy, and environment are matched to the sales growth of newly founded semiconductor firms. Results show that the effects of the founding team and environment grew instead of fading with time. Includes 54…

  13. Constitutionalism in Education for Democracy: The Continuing Relevance of Arguments on Constitutional Government of the American Founding Era.

    Science.gov (United States)

    Patrick, John J.

    This paper contends that the issues of constitutional government debated during the founding of the United States should be in the core curriculum of any school that seeks to educate students to become responsible citizens of a constitutional democracy. For purposes of teaching students, the issues debated by founding-era political thinkers can be…

  14. The Worldwide Growth of Private Higher Education: Cross-National Patterns of Higher Education Institution Foundings by Sector

    Science.gov (United States)

    Buckner, Elizabeth

    2017-01-01

    This article investigates cross-national patterns of public and private higher education institution (HEI) foundings from 1960 to 2006. It argues that in addition to national demographic and economic factors, patterns of HEI foundings also reflect world-level models about how nations should structure their higher education systems. Findings…

  15. Surveys of forest bird populations found in the vicinity of proposed geothermal project subzones in the district of Puna, Hawaii

    Energy Technology Data Exchange (ETDEWEB)

    Jacobi, J.D.; Reynolds, M.; Ritchotte, G.; Nielsen, B.; Viggiano, A.; Dwyer, J.

    1994-10-01

    This report presents data on the distribution and status of forest bird species found within the vicinity of proposed geothermal resource development on the Island of Hawaii. Potential impacts of the proposed development on the native bird populations found in the project are are addressed.

  16. Measurement of aqueous Henry's law constants for oxygenates and aromatics found in gasolines by the static headspace method

    Science.gov (United States)

    Miller; Stuart

    2000-02-01

    A simple equilibrium vessel made from a large stopcock was used in conjunction with the static headspace method to measure the aqueous Henry's law constants for methyl tert-butyl ether (MTBE) and other potential oxygenates as well as certain of the aromatics found in gasoline. The present method involves using only one aqueous solution whose concentration is not necessarily known. The only quantity that must be known is the phase ratio. Plotting a series of peak areas of the analyte in the headspace after each equilibrium change against the initial peak area of the analyte found in the headspace leads to a linear relationship whose slope is dependent on the analyte's unitless Henry's law constant and the phase ratio. This new method is found to yield unitless aqueous Henry's law constants in the range from 0.02 to 0.2, which are especially applicable to the oxygenates and aromatics found in gasolines.

  17. THE EXPRESSIONS OF REQUEST FOUND IN NANNY MC PHEE AND THE BIG BANG MOVIE BY SUSANNA WHITE: PRAGMATICS ANALYSIS

    OpenAIRE

    Ika Ida Wijayanti

    2012-01-01

    This study is aimed at analyzing request expressions found in Nanny McPhee and the Big Bang movie by Susanna White, focusing on the pragmalinguistics for request ex- pressions, the illocution of request expression, and the request strategy in this movie. The data of this research are sentences containing request expressions found in the movie. The researcher finds 118 request expressions in the movie. The method of collecting the data in this research are watching the original Movie, note tak...

  18. [Long-term follow-up of children with prenatally found increased nuchal translucency and normal karyotype].

    Science.gov (United States)

    Kornacki, Jakub; Ziółkowska, Katarzyna; Ignaszak, Natalia; Skrzypczak, Jana

    2015-01-01

    The aim of the study was a long-term follow-up of children with prenatally found increased nuchal translucency (NT) and normal karyotype. The study was conducted among 147 pregnant women who underwent amniocentesis due to increased fetal NT with or without other structural anomalies in the fetus. The final analysis concerned children with prenatally found increased NT and normal karyotype who were at least 2 years of age. A questionnaire was sent to all patients who underwent amniocentesis in order to assess the development of the children. Normal karyotype was found in 101 (68.7%) fetuses with increased NT Complete information on the outcome of pregnancy and further development of the children was submitted by 70 patients (69.3%). An abnormal outcome of pregnancy congenital structural anomalies and abnormal development was found finally in 17.1% of the children. In case of normal result of the second-trimester fetal ultrasound scan, normal further development was found in 93% of the children. 1. Further development of the children with prenatally found increased NT and normal karyotype is usually normal. 2. The degree of NT increase and the result of the second-trimester fetal anatomy scan seem to play the key role in the prognosis of further, postnatal outcome of the fetuses with increased NT 3. Normal karyotype in fetuses with increased NT does not exclude the possibility of an existing genetic syndrome.

  19. Trace-elements, methylmercury and metallothionein levels in Magellanic penguin (Spheniscus magellanicus) found stranded on the Southern Brazilian coast.

    Science.gov (United States)

    Kehrig, Helena A; Hauser-Davis, Rachel A; Seixas, Tércia G; Fillmann, Gilberto

    2015-07-15

    Magellanic penguins have been reported as good biomonitors for several types of pollutants, including trace-elements. In this context, selenium (Se), total mercury, methylmercury, inorganic mercury (Hg(inorg)), cadmium (Cd) and lead (Pb), as well as metallothionein (MT) levels, were evaluated in the feathers, liver and kidney of juvenile Magellanic penguins found stranded along the coast of Southern Brazil. The highest concentrations of all trace-elements and methylmercury were found in internal organs. Concentrations of Cd and Se in feathers were extremely low in comparison with their concentrations in soft tissues. The results showed that both Se and MT are involved in the detoxification of trace-elements (Cd, Pb and Hg(inorg)) since statistically significant relationships were found in liver. Conversely, hepatic Se was shown to be the only detoxifying agent for methylmercury. Copyright © 2015 Elsevier Ltd. All rights reserved.

  20. New rabies virus variant found during an epizootic in white-nosed coatis from the Yucatan Peninsula.

    Science.gov (United States)

    Aréchiga-Ceballos, N; Velasco-Villa, A; Shi, M; Flores-Chávez, S; Barrón, B; Cuevas-Domínguez, E; González-Origel, A; Aguilar-Setién, A

    2010-11-01

    In February 2008, three white-nosed coatis (Nasua narica) were found dead in a recreational park in Cancun, Mexico. The diagnosis of rabies virus (RABV) infection was confirmed by direct immunofluorescence test. The phylogenetic analysis performed with the complete RABV nucleoprotein gene positioned this isolate close to a sequence of a human rabies case reported during 2008 from Oaxaca, Mexico, sharing 93% similarity. In turn, these two variants are related to another variant found in rabid Tadarida brasiliensis mexicana bats across North America. Anti-RABV neutralizing activity (1.3 IU/ml) was found in the serum of one white-nosed coati captured with another five that cohabited with the dead animals. Enhanced rabies surveillance and pathogenesis studies should be conducted in coatis and insectivorous bats of the region to clarify the role of these species as potential emergent or long-term unidentified RABV reservoirs.

  1. A branch point consensus from Arabidopsis found by non-circular analysis allows for better prediction of acceptor sites

    DEFF Research Database (Denmark)

    Tolstrup, Niels; Rouzé, Pierre; Brunak, Søren

    1997-01-01

    found by the Markov model shares features with the metazoan consensus, but differs in its details from the consensus proposed earlier. Despite the fact that branch point consensus sequences in plants are weak, we show that a prediction scheme incorporating them leads to a substantial improvement......Little knowledge exists about branch points in plants; it has even been claimed that plant introns lack conserved branch point sequences similar to those found in vertebrate introns. A putative branch point consensus sequence for Arabidopsis thaliana resembling the well known metazoan consensus...... in the recognition of true acceptor sites; the false positive rate being reduced by a factor of 2. We take this as an indication that the consensus found here is the genuine one and that the branch point does play a role in the proper recognition of the acceptor site in plants....

  2. Structures of Two Yellow Dyes Found in Cucumbers Pickled in Soy Sauce Colored with Tartrazine (Y4).

    Science.gov (United States)

    Ogawa, Asamoe; Shindo, Tetsuya; Kyoko, Hitomi; Sadamasu, Yuki; Sakamaki, Narue; Uematsu, Yoko; Monma, Kimio

    2017-01-01

    Two yellow dyes, together with tartrazine (Y4), were found in cucumbers pickled in soy sauce, for which the use of tartrazine is permitted, by TLC, LC-DAD, and LC-MS. The retention times on LC chromatograms and the maximum absorbance wavelengths measured by LC-DAD of the two dyes were different from those of tartrazine. Mass spectra of the dyes indicated that these dyes lacked one sulfonyl group of tartrazine. The presence of two less sulfonated dyes in tartrazine has been reported. Hence, the two less sulfonated dyes were synthesized. The two dyes found in cucumbers were compared with the synthesized dyes by LC-DAD and LC-MS. Since the retention times of the dyes in cucumbers on the LC chromatograms, as well as their LC-DAD spectra and mass spectra, were found to be identical with those of the synthesized dyes, we concluded these dyes are the less sulfonated subsidiary dyes of tartrazine.

  3. Saduria entomon infected with Hysterothylacium aduncum found in situ in the stomach of cod (Gadus morhua) from the Baltic Sea.

    Science.gov (United States)

    Pawlak, J; Nadolna-Ałtyn, K; Szostakowska, B; Pachur, M; Podolska, M

    2017-10-12

    The parasite fauna of cod (Gadus morhus) is well described, but the life cycles of Baltic cod parasites are known only in general terms. Invertebrates commonly found in the stomach of cod are recognized as intermediate hosts in the life cycles of nematodes or acanthocephalans. The aim of this study was to determine the source of infection of Baltic cod with parasites found in situ in invertebrates present in the cod stomach. Our results indicate that Saduria entomon is both a source of infection of Baltic cod with parasites and an intermediate host in the life cycle of Hysterothylacium aduncum in the Baltic Sea.

  4. Simplified Dynamic Structural Time History Response Analysis of Flexible Approach Walls Founded on Clustered Pile Groups Using Impact_Deck

    Science.gov (United States)

    2016-07-01

    Approach Walls Founded on Clustered Pile Groups Using Impact_Deck In fo rm at io n an d Te ch no lo gy L ab or at or y Barry C. White, José...Time-History Response Analysis of Flexible Approach Walls Founded on Clustered Pile Groups Using Impact_Deck Barry C. White and Robert M. Ebeling...clustered pile groups and subjected to barge train impact events. This software tool, Impact_Deck, is used to perform a dynamic, time- domain

  5. The capybara, Hydrochoerus hydrochaeris (Mammalia: Rodentia, found at the archaeological site SC PRV 02, Santa Catarina Island, Brasil

    Directory of Open Access Journals (Sweden)

    Paulo César Simões-Lopes

    2005-11-01

    Full Text Available Santa Catarina Island possesses dozens of archeological sites where the skeletal remains of a great array of animals can be found. The goal of this study was to quantify the skeletal remains of capybaras found at the archeological site SC PRV 02 (1067 to 1735 BP, located in the northern part of the island, along the shores of Lagoa da Conceição, a saltwater lagoon. Thirty-seven skeletal fragments of at least 12 different individuals were identified. The anatomic regions of the capybaras most sought-after by pre-colonial inhabitants were the anterior and posterior limbs. About 40% of the skeletal fragments did not show any epiphyseal fusion with the shaft. Approximately 48% of the fragments found presented evidence of human activity. Our analyses suggest that capybaras played an important role in the diet of these inhabitants and that they were also used for the confection of different functional goods. We diagnosed the manipulation techniques used to obtain these goods, such as percussion and transversal section. The evidence of carbonization and superficial incisions indicates dismembering, preparation, and consumption of capybaras for feeding. Similar techniques were found at other archeological sites of the same age, suggesting that even though pre-colonial inhabitants of the island were considered to be fishermen, capybaras represented a well-appreciated resource.

  6. Association study of the estrogen receptor I gene (ESR1) in anorexia nervosa and eating disorders: No replication found

    NARCIS (Netherlands)

    Slof-Op 't Landt, M.C.T.; van Furth, E.F.; Meulenbelt, I.; Bartels, M.; Slagboom, P.E.; Boomsma, D.I.

    2014-01-01

    Objective The female preponderance and onset around puberty in the majority of eating disorders (EDs) suggest that sex hormones, like estrogens, may be involved in the onset of these disorders. An eight-SNP haplotype at the estrogen receptor I (ESR1) gene was found to be associated with anorexia

  7. Large amounts of marine debris found in sperm whales stranded along the North Sea coast in early 2016

    NARCIS (Netherlands)

    Unger, Bianca; Bravo Rebolledo, Elisa; Deaville, Rob; Gröne, Andrea; IJsseldijk, Lonneke L.; Leopold, Mardik F.; Siebert, Ursula; Spitz, Jérôme; Wohlsein, Peter; Herr, Helena

    2016-01-01

    30 sperm whales (Physeter macrocephalus) stranded along the coasts of the North Sea between January and February 2016. The gastro-intestinal tracts of 22 of the carcasses were investigated. Marine debris including netting, ropes, foils, packaging material and a part of a car were found in nine of

  8. Large amounts of marine debris found in sperm whales stranded along the North Sea coast in early 2016

    NARCIS (Netherlands)

    Unger, Bianca; Rebolledo, Elisa L Bravo; Deaville, Rob; Gröne, Andrea; IJsseldijk, Lonneke L; Leopold, Mardik F; Siebert, Ursula; Spitz, Jérôme; Wohlsein, Peter; Herr, Helena

    2016-01-01

    30 sperm whales (Physeter macrocephalus) stranded along the coasts of the North Sea between January and February 2016. The gastro-intestinal tracts of 22 of the carcasses were investigated. Marine debris including netting, ropes, foils, packaging material and a part of a car were found in nine of

  9. Natural habitats uncovered? – Genetic structure of known and newly found localities of the endangered bitterling Pseudorhodeus tanago (Cyprinidae

    Directory of Open Access Journals (Sweden)

    Kenji Saitoh

    2017-03-01

    Full Text Available Overuse of natural resources by humans is a major threat to biodiversity. Overuse often involves species of economic or esthetic value, and fish are a typical example for a group that is exploited both for economic reasons (for human consumption and for esthetic reasons (e.g. by aquarists. Pseudorhodeus tanago (Tanaka, 1909 (formerly known as Tanakia tanago is a small colorful but legally protected (fishing, keeping and transfer are banned bitterling fish distributed around Tokyo, Japan. Whereas it is critically endangered and more and more habitat loss has occurred, at least four stocks have been newly found during the last decade. To explore whether emergence of these newly found habitats is a consequence of incomplete survey, we genotyped mitochondrial cytochrome b sequence of P. tanago from 17 localities and an illegal home aquarium. Populations known by the past extensive survey (13 localities showed geographically structured population genetic characteristics. Population-specific haplotypes were common indicating past divergence and bottleneck events. Four (north, {center + west}, south_1, south_2 or five (north, center, west, south_1, south_2 geographic groups were detectable as for these known localities. On the other hand, newly found stocks were polymorphic and showed identical haplotypes from distant known localities. If we assume historical basis of distribution and genetic characteristics of these newly found stocks, it must be a series of unlikely geological events and haplotype sorting. We discuss potential issues posed by these questionable stocks.

  10. "Well Acquainted with Books." The Founding Framers of 1787. With James Madison's List of Books for Congress.

    Science.gov (United States)

    Rutland, Robert A.

    Published to commemorate the Constitution's bicentennial year and remind Americans that books and the life of the mind are vital national traditions, this volume contains both an essay, "Well Acquainted with Books: The Founding Framers of 1787," by Robert A. Rutland, and James Madison's List of Books for Congress, 1783. The essay…

  11. Transmission of Citrus leprosis virus C by Brevipalpus phoenicis (Geijskes) to Alternative Host Plants Found in Citrus Orchards

    Science.gov (United States)

    The equivalent of US$ 75 million is spent each year in Brazil to control Brevipalpus phoenicis, a mite vector of Citrus leprosis virus C (CiLV-C). In this study we investigated the possibility that hedgerows, windbreaks, and weeds normally found in citrus orchards could host CiLV-C. Mites reared on ...

  12. Hydra II: A Faint and Compact Milky Way Dwarf Galaxy Found in the Survey of the Magellanic Stellar History

    NARCIS (Netherlands)

    Martin, Nicolas F.; Nidever, David L.; Besla, Gurtina; Olsen, Knut; Walker, Alistair R.; Vivas, A. Katherina; Gruendl, Robert A.; Kaleida, Catherine C.; Muñoz, Ricardo R.; Blum, Robert D.; Saha, Abhijit; Conn, Blair C.; Bell, Eric F.; Chu, You-Hua; Cioni, Maria-Rosa L.; de Boer, Thomas J. L.; Gallart, Carme; Jin, Shoko; Kunder, Andrea; Majewski, Steven R.; Martinez-Delgado, David; Monachesi, Antonela; Monelli, Matteo; Monteagudo, Lara; Noël, Noelia E. D.; Olszewski, Edward W.; Stringfellow, Guy S.; van der Marel, Roeland P.; Zaritsky, Dennis

    We present the discovery of a new dwarf galaxy, Hydra II, found serendipitously within the data from the ongoing Survey of the Magellanic Stellar History conducted with the Dark Energy Camera on the Blanco 4 m Telescope. The new satellite is compact ({{r}h}=68 ± 11 pc) and faint ({{M}V}=-4.8 ± 0.3),

  13. Leaving the Space Better than You Found It through Song: Music, Diversity, and Mission in One Black Student Organization

    Science.gov (United States)

    Deckman, Sherry L.

    2013-01-01

    In recounting the history and present dynamics in the Kuumba Singers of Harvard College, Sherry Deckman presents a portrait of what it means to leave a space better than you found it through song. The story of Kuumba--Harvard's oldest black student organization and now its largest multicultural organization--is told through the experiences of…

  14. Infection and transmission of Nosema bombi in Bombus terrestris colonies and its effect on hibernation, mating and colony founding

    NARCIS (Netherlands)

    Steen, van der J.J.M.

    2008-01-01

    The impact of the microsporidium Nosema bombi on Bombus terrestris was studied by recording mating, hibernation success, protein titre in haemolymph, weight change during hibernation, and colony founding of queens that were inoculated with N. bombi in the larval phase. Infection with N. bombi was

  15. EROs found behind lensing clusters: II. Empirical properties, classification, and SED modelling based on multi-wavelength observations

    NARCIS (Netherlands)

    Hempel, A.; Schaerer, D.; Egami, E.; Pelló, R.; Wise, M.; Richard, J.; Le Borgne, J.F.; Kneib, J.P.

    2008-01-01

    Aims. We study the properties and nature of extremely red galaxies (FRO, R-K >= 5.6) found behind two lensing clusters and compare them with other known galaxy populations. Methods. New HST/ACS, Spitzer (TRAC and MIPS), and Chandra/ACIS observations of the two lensing clusters Abell 1835 and AC 114

  16. Charles Darwin’s lost Cinereous Harrier found in the collection of the National Museum of Natural History Leiden

    NARCIS (Netherlands)

    Grouw, van H.; Steinheimer, F.D.

    2008-01-01

    During reorganisation of the Leiden bird collection a mounted harrier was found what seemed to be one of the still lost specimens collected by Darwin. After closer research it turned out it was indeed the last missing harrier of the Darwin collection.

  17. Designing an Education for Life in Two Worlds: The Founding of the Bureau of Jewish Education of New York City.

    Science.gov (United States)

    Brumberg, Stephen F.

    The Bureau of Jewish Education, founded in 1910 as part of the Kehillah (Jewish Community) of New York City, had a seminal and lasting influence on the education of Jews in America. The New Jewish Educators trained at the Bureau stressed the cultural breadth and historical depth of Judaism while emphasizing that Jewish education was supplementary…

  18. Development and Validation of Methodology to Model Flow in Ventilation Systems Commonly Found in Nuclear Facilities. Phase I

    Energy Technology Data Exchange (ETDEWEB)

    Strons, Philip [Argonne National Lab. (ANL), Argonne, IL (United States); Bailey, James L. [Argonne National Lab. (ANL), Argonne, IL (United States); Davis, John [Argonne National Lab. (ANL), Argonne, IL (United States); Grudzinski, James [Argonne National Lab. (ANL), Argonne, IL (United States); Hlotke, John [Argonne National Lab. (ANL), Argonne, IL (United States)

    2016-03-01

    In this work, we apply the CFD in modeling airflow and particulate transport. This modeling is then compared to field validation studies to both inform and validate the modeling assumptions. Based on the results of field tests, modeling assumptions and boundary conditions are refined and the process is repeated until the results are found to be reliable with a high level of confidence.

  19. Pre-Service Social Studies Teachers' Viewpoints about Atatürk as Founding and Transformational Leader

    Science.gov (United States)

    Dönmez, Cengiz; Uslu, Salih; Hamarat, Ercenk

    2017-01-01

    The aim of the current study is to identify the opinions of pre-service social studies teachers about Atatürk as a founding and transformational leader. The sample of the study comprises 180 pre-service teachers in the social studies teaching department of an education faculty in a public university. The data have been collected through an…

  20. Comparison of immune response to lipopolysaccharide of rabbit does selected for litter size at weaning or founded for reproductive longevity

    DEFF Research Database (Denmark)

    Ferrian, S; Blas, E; Larsen, Torben

    2013-01-01

    To evaluate differences in maternal lines to the immune response of reproductive rabbit does, a total of 64 animals of two different lines: (1) founded for hyper-longevity and litter size criteria (LP) and (2) selected for litter size at weaning (V) were used. Females were subjected to three diff...

  1. Invasive plants found in North Carolina’s forests, 2010—forest inventory and analysis factsheet

    Science.gov (United States)

    Christopher M. Oswalt; Sonja N. Oswalt

    2014-01-01

    This publication provides an overview of invasive plants found in forests of the State of North Carolina based on an annual inventory conducted by the Forest Inventory and Analysis (FIA) Program at the Southern Research Station (SRS) of the Forest Service, U.S. Department of Agriculture in cooperation with the North Carolina Forest Service. These estimates and coverage...

  2. The first wolf found in the Netherlands in 150 years was the victim of a wildlife crime

    NARCIS (Netherlands)

    Gravendeel, B.; Groot, de G.A.; Kik, M.; Beentjes, K.; Bergman, H.; Caniglia, R.; Cremers, H.; Fabbri, E.; Groenenberg, D.; Grone, A.; Groot Bruinderink, G.W.T.A.; Font, I.; Hakhof, J.; Harms, V.; Jansman, H.A.H.; Janssen, R.; Lammertsma, D.R.; Laros, I.; Linnartz, L.; Marel, van der D.; Mulder, J.L.; Mije, van der S.; Nieman, A.M.; Nowak, C.; Randi, E.; Rijks, M.; Speksnijder, A.; Vonhof, H.B.

    2013-01-01

    On July 4th 2013 a dead subadult female wolf-like canid was found by the roadside between Luttelgeest and Marknesse in the Noordoostpolder in the central part of the Netherlands. As the last observations of wild wolves in the Netherlands date back to 1869 the discovery of this animal generated a lot

  3. Evaluating the prevalence of DNA mixtures found in fingernail samples from victims and suspects in homicide cases.

    Science.gov (United States)

    Nurit, Bublil; Anat, Gast; Michal, Shenfeld; Lilach, Front; Maya, Freund

    2011-11-01

    An important aspect of homicide investigations is the identification of the persons that had the last contact with the victim prior to death. Violent crimes are frequently characterized by a struggle between the victim and the perpetrator where biological material can be expected to be exchanged between them. Forensic DNA typing enables the generation of genetic profiles by extraction and amplification of cellular material found under fingernails. The evidential value of these samples may be critical if the secondary contributor found in a DNA mixture, can be matched with a potential suspect, or through a DNA database search. The amount of biological material transferred under the fingernails during "casual" activities is not sufficient to genotype reportable mixtures. This may not be the case with homicide victims that may have struggled and died under violent circumstances. The aim of this study was to evaluate the prevalence of DNA mixtures found under the fingernails of both victims and suspected perpetrators of violent deaths. We present a retrospective study of 137 DNA profiles genotyped from fingernail samples of homicide victims and suspects, collected at the Israeli National Center of Forensic Medicine. The majority of the samples produced single source profiles (n=107, 78%) that matched those of the donor's. DNA mixtures (n=30, 22%) were found in increased frequency among victims (n=25/100, 25%) compared to suspects (n=5/37, 13.5%). Mixtures were sub-divided into high level (n=15, 50%), low level (n=9, 30%) and residual (n=6, 20%), according to the number of the foreign contributors' alleles. Thus, this distinctive group of homicide victims was found to express both elevated frequency of DNA mixtures together with highly informative value of the secondary foreign profiles, as compared to other studied populations. These findings support an important aspect for the criminal investigation in murder cases, where a struggle may have ensued and the

  4. Factors associated with a depressive disorder in Alzheimer's disease are different from those found for other dementia disorders.

    Science.gov (United States)

    Barca, Maria Lage; Engedal, Knut; Laks, Jerson; Selbaek, Geir

    2012-01-01

    This study explores factors associated with depression in Alzheimer's disease (AD) compared with mild cognitive impairment (MCI) and other dementia disorders. In a prospective study we included 195 patients: 31 with MCI, 112 with AD and 52 with other dementias. According to the ICD-10 and the DSM-IV criteria, 88 (44.1%) and 59 (30.3%), respectively, had a depressive disorder. An adjusted multiple regression analysis showed that previous depression (p depression in AD patients. Severity of dementia (p depressive disorder in a group of patients with frontotemporal dementia, vascular dementia, or dementia due to Lewy Body disease or Parkinson's disease. We found different factors associated with a depressive disorder in AD compared to those found for other dementia disorders.

  5. Founding weaver ant queens (Oecophylla longinoda) increase production and nanitic worker size when adopting non-nestmate pupae

    DEFF Research Database (Denmark)

    Ouagoussounon, Issa; Offenberg, Joachim; Sinzogan, Antonio

    2015-01-01

    Weaver ants (Oecophylla longinoda Latreille) are used commercially to control pest insects and for protein production. In this respect fast colony growth is desirable for managed colonies. Transplantation of non-nestmate pupae to incipient colonies has been shown to boost colony growth. Our...... objectives were to find the maximum number of pupae a founding queen can handle, and to measure the associated colony growth. Secondly, we tested if transplantation of pupae led to production of larger nanitic workers (defined as unusually small worker ants produced by founding queens in their first batch...... of offspring). Forty-five fertilized queens were divided into three treatments: 0 (control), 100 or 300 non-nestmate pupae transplanted to each colony. Pupae transplantation resulted in highly increased growth rates, as pupae were readily adopted by the queens and showed high proportions of surviving (mean...

  6. Preserved scleral patch graft for unexpected extreme scleral thinning found at the scleral buckling procedure: A case report

    Directory of Open Access Journals (Sweden)

    Spela Stunf

    2011-01-01

    Full Text Available Pre-existing scleral pathology is an important risk factor for globe rupture during scleral buckling procedures. We report here, the surgical management of an unexpected scleral pathology found at the scleral buckling procedure in a retinal detachment patient. A 77-year-old white female with retinal detachment underwent a scleral buckling procedure. The surgery was converted into a scleral graft procedure, as extreme scleral thinning was found intraoperatively. An alcohol-preserved donor sclera graft was used. The second surgery for definitive retinal alignment was performed two weeks later. The presented case of an unexpected scleral pathology in a retinal detachment patient was managed with a combination of scleral grafting and pars plana vitrectomy, without any major complications. The anatomical outcome was excellent and the scleral rupture was prevented; the visual outcome was satisfactory. A conversion of the scleral buckling procedure into a scleral graft procedure has proved to be safe and effective for unexpected scleral pathology.

  7. Diptera Brachycera found inside the esophagus of a mummified adult male from the early XIX century, Lisbon, Portugal

    Directory of Open Access Journals (Sweden)

    Márcia Souto Couri

    2008-03-01

    Full Text Available Fly puparia and adult fragments of diptera muscid were found inside the esophagus of a mummified body from the early XIX century, buried inside the crypt of the Sacrament Church (Lisbon, Portugal. The identification of the material revealed a monospecific colonization by Ophyra capensis (Wiedemann (Diptera: Muscidae, a species known to invade corpses in the ammoniacal fermentation wave. This species can be found in corpses kept indoors, not available to the early waves of blowflies (Diptera: Calliphoridae. In the present case, the number of pupae and their developmental stage suggest that the female invaded the mummified corpse through the partially opened mouth and the oviposition took place directly inside the esophagus. This is the first case of O. capensis infesting internal organs of an intact corpse. The use of chemical products for the embalming process probably explains why external colonization did not occur.

  8. Mutations in MYH9 exons 1, 16, 26, and 30 are infrequently found in Japanese patients with nonsyndromic deafness.

    Science.gov (United States)

    Kunishima, Shinji; Matsunaga, Tatsuo; Ito, Yoshimi; Saito, Hidehiko

    2009-10-01

    Mutations in MYH9 result in the autosomal dominant giant platelet disorders with leukocyte inclusion bodies with varying degrees of Alport manifestations, including nephritis, deafness, and cataracts. A specific MYH9 mutation in exon 16, R705H, causes nonsyndromic deafness DFNA17. We searched for mutations in MYH9 exons 1, 16, 26, and 30 in a total of 157 Japanese patients with nonsyndromic deafness without known cause of hearing loss, but no mutations were found. We conclude that mutations in MYH9 are infrequently found in patients with nonsyndromic deafness and suggest that MYH9 mutations infrequently cause isolated sensorineural hearing loss. Thus, MYH9 may not currently be a good candidate gene for efficient screening of genetic causes in nonsyndromic deafness.

  9. Investigation of the impurities found in methamphetamine synthesised from pseudoephedrine by reduction with hydriodic acid and red phosphorus.

    Science.gov (United States)

    Windahl, K L; McTigue, M J; Pearson, J R; Pratt, S J; Rowe, J E; Sear, E M

    1995-12-18

    The synthesis of methamphetamine from pseudoephedrine via the reduction with hydriodic acid and red phosphorus was studied and the impurities which were generated, along with the methamphetamine, were investigated. Some of the impurities found have been reported previously, while the diastereoisomers of N-methyl-N-(alpha- methylphenethyl)amino-1-phenyl-2-propanone and the cis-cinnamoyl derivative of methamphetamine are reported here for the first time. Further work on the sequence of reactions occurring in this reduction is also reported.

  10. Characterization of a New Tomato Spotted Wilt Virus Isolates Found in Hippeastrum hybridum (Hort.) Plants in Poland

    OpenAIRE

    Berniak Hanna

    2016-01-01

    Two Tomato spotted wilt virus (TSWV) isolates H1 and H2 found in Hippeastrum hybridum plants were characterized based on biological, serological, and molecular properties. Virus isolates showed differences in symptom expression – H1 isolate displayed severe necrotic spots and patterns, whereas mild mosaic symptoms were observed on H2-infected H. hybridum plants. Both TSWV isolates showed comparable reactivity with TSWV-specific antibodies and they induced similar symptoms on herbaceous indica...

  11. "Everything was a Stage": An Oral History with Ruth Solomon, Founding UCSC Professor of Theater Arts and Dance

    OpenAIRE

    Reti, Irene H.; Beal, Tandy

    2014-01-01

    Ruth Solomon arrived at the University of California, Santa Cruz in 1970 as a professor in the theater arts board and an affiliate of the brand-new College Five (now Porter College). At UC Santa Cruz, Solomon created a visionary program within the theater arts board that synthesized dance and theater. She taught at UC Santa Cruz until 1995. Solomon also founded and coordinated UCSC’s prestigious Summer Dance Theater Institute from 1972 until 1980. In 1953 Solomon entered Bard College...

  12. Topological and Mutational Analysis of Saccharomyces cerevisiae Ste14p, Founding Member of the Isoprenylcysteine Carboxyl Methyltransferase Family

    OpenAIRE

    Romano, Julia D.; Michaelis, Susan

    2001-01-01

    Eukaryotic proteins that terminate in a CaaX motif undergo three processing events: isoprenylation, C-terminal proteolytic cleavage, and carboxyl methylation. In Saccharomyces cerevisiae, the latter step is mediated by Ste14p, an integral endoplasmic reticulum membrane protein. Ste14p is the founding member of the isoprenylcysteine carboxyl methyltransferase (ICMT) family, whose members share significant sequence homology. Because the physiological substrates of St...

  13. An Analysis Of The Five Language Styles Found In The Movie “The Pursuit Of Happyness

    OpenAIRE

    Lubis, Ayu Septiani

    2010-01-01

    Dalam skripsi yang berjudul An Analysis Of The Five Language Styles Found In The Movie “The Pursuit Of Happyness”, penulis menganalisis lima jenis ragam bahasa yang dibedakan menurut teori Martin Joos (1967). Ragam bahasa ini dapat diidentifikasi melalui situasi disaat pembicara berbicara, apakah itu resmi atau santai, umum atau rahasia, siapakah yang mendengarkan kita sewaktu berbicara, apakah itu teman kita, orangtua ataupun orang yang belum kita kenal. Penulis menggunakan 30 data dari perc...

  14. Lobular neoplasia found on breast biopsy: marker of increased risk of malignancy or direct pre-cancerous lesion?

    Directory of Open Access Journals (Sweden)

    Jan Kornafel

    2011-10-01

    Full Text Available The aim of this study was to compare the imaging symptoms and microscopic findings in females with lobular neoplasia (LN found on biopsy. 1,478 women who underwent primary open biopsy or surgical excision after percutaneous biopsy were reviewed. In 24 of them (1.6%, LN was found. In four patients, excisional biopsy with hook-wire localization was done primarily due to the radial scar. In 20 females, surgical excision of BIRADS 4 lesion was performed because of the presence of LN in specimens from the vacuum-assisted or core-needle percutaneous biopsy. Postoperative pathologic findings were compared to the radiological symptoms. In 13 women, LN did not produce any radiological symptoms and was an additional histologic finding existing near the other lesion: fibroadenoma and radial scar. In none of these lesions was an invasive cancer noticed. In one single patient, ductal carcinoma in situ was observed in the other segment of the breast. Invasive ductal cancer developed in the contralateral breast in one patient. In 11 patients, LN was diagnosed due to radiological symptoms produced by itself. In this group, the invasive lobular cancer was found in seven lesions (64%. Our finding suggests that LN producing suspicious radiological symptoms can be a different biologic type of this lesion when compared asymptomatic LN diagnosed which is usually found on biopsy as additional microscopic pathology. Symptomatic LN is probably associated with a higher potential of malignant transformation. (Folia Histochemica et Cytobiologica 2011; Vol. 49, No. 3, pp. 417–424

  15. What lies within; Annelid polychaetes found in micro-habitats of coral/carbonate material from SW Indian ocean seamounts

    Science.gov (United States)

    Narayanaswamy, Bhavani E.; Rea, T.; Serpetti, N.; Lamont, P. A.

    2017-03-01

    Individual corals, coral framework and rubble are generally quite abundant on seamounts, with carbonate materials derived from an unknown source also being found. These micro-habitats are known to often harbour higher abundance of smaller sized fauna and thus potentially increases the biodiversity of that region. However, very few studies have examined what may reside within the coral and carbonate structures themselves, if anything at all. Samples that were collected on five seamounts during a research cruise to the South West Indian Ocean Ridge in 2011, were examined opportunistically in order to determine if there were any animals to be found inside the hard coral framework/rubble material. The hard material was dissolved away using 10% acetic acid and was examined on a twice daily basis to remove any animals that had been released through the dissolution process. There were a surprising number of phyla found inside the micro-habitats created by the coral rubble/framework material including sponges, brachiopods and a number of different polychaete families. As the polychaetes were more numerous, they were investigated more closely and a total of 34 different families were identified, with the Syllidae being found in every sample examined. The methodology presented here highlights that a "controlled" weak acid dissolution can be used to release the fauna from deep inside the coral rubble/framework material. Frequent removal (twice daily or more often) of liberated material meant that the fauna released were exposed to the acid for a minimum amount of time resulting in specimens in better condition and with more identifiable features. The preliminary results also illustrate the importance of sampling the dead coral framework/rubble/carbonate material, not only to identify them for what they are, but to look more closely at the fauna residing inside the structure themselves.

  16. I Still Haven’t Found What I’m Looking For….. Bono, Google and Glaucoma Awareness

    LENUS (Irish Health Repository)

    Lyons, C

    2017-05-01

    The effect of celebrity diagnosis on public awareness of health conditions has already been well documented. In October 2014, Bono, the lead singer with U2, revealed publicly for the first time that he has glaucoma. This study aimed to analyze the impact of Bono’s announcement on public awareness of glaucoma using Google Search trends as an indicator of public interest in the disease. Google Trends was used to examine Google Search activity for the term ‘Glaucoma’ between 2009 and 2015 in both Ireland and the United Kingdom. Trend analyses were performed using Microsoft Excel Version 14.3.5. Increased Google Search activity for ‘Glaucoma’ in October 2014 was found in both Ireland and the United Kingdom. A five-fold increase from the mean Google Search activity for this term was found in Ireland and a two-fold increase from the mean Google Search activity for this term was found in the United Kingdom. No such increase in Google Search activity occurred during each country’s 2014 Glaucoma Awareness week. Google Trends is useful in medical research as a means of assessing public awareness of, and\\/or interest in, health related topics. Current approaches to glaucoma related health promotion in both Ireland and the United Kingdom have failed to yield an increase in on-line Google Search activity. While there was an increase in interest in glaucoma it is unclear whether this led to an increase in health seeking behaviour.

  17. Phytoremedial Potential of Typha latifolia, Eichornia crassipes and Monochoria hastata found in Contaminated Water Bodies Across Ranchi City (India).

    Science.gov (United States)

    Hazra, Moushumi; Avishek, Kirti; Pathak, Gopal

    2015-01-01

    Phytoremediation is an emerging technology that uses green plants (living machines) for removal of contaminants of concern (COC). These plant species have the potential to remove the COC, thereby restoring the original condition of soil or water environment. The present study focuses on assessing the heavy metals (COC) present in the contaminated water bodies of Ranchi city, Jharkhand, India. Phytoremedial potential of three plant species: Typha latifolia, Eichornia crassipes and Monochoria hastata were assessed in the present study. Heterogenous accumulation of metals was found in the three plant species. It was observed that the ratio of heavy metal concentration was different in different parts, i.e., shoots and roots. Positive results were also obtained for translocation factor of all species with minimum of 0.10 and maximum of 1. It was found experimentally that M. hastata has the maximum BFC for root as 4.32 and shoot as 2.70 (for Manganese). For T. latifolia, BCF of maximum was observed for root (163.5) and respective shoot 86.46 (for Iron), followed by 7.3 and 5.8 for root and shoot (for Manganese) respectively. E. crassipes was found to possess a maximum BCF of 278.6 (for Manganese and 151 (for Iron) and shoot as 142 (for Manganese) and 36.13 (for Iron).

  18. Characterization of a New Tomato Spotted Wilt Virus Isolates Found in Hippeastrum hybridum (Hort. Plants in Poland

    Directory of Open Access Journals (Sweden)

    Berniak Hanna

    2016-06-01

    Full Text Available Two Tomato spotted wilt virus (TSWV isolates H1 and H2 found in Hippeastrum hybridum plants were characterized based on biological, serological, and molecular properties. Virus isolates showed differences in symptom expression – H1 isolate displayed severe necrotic spots and patterns, whereas mild mosaic symptoms were observed on H2-infected H. hybridum plants. Both TSWV isolates showed comparable reactivity with TSWV-specific antibodies and they induced similar symptoms on herbaceous indicator plants, but some differences between these isolates were detected at the nucleotide sequence level of genomic S and M ssRNAs segment fragments. The nucleotide sequences encoding nucleocapsid (N and nonstructural (NSs and NSm proteins showed 98.2%, 97.5%, and 96.5% identity, respectively. Phylogenetic analysis of N and NSs sequences conducted for tested isolates and 31 TSWV isolates included for comparison revealed that H1 and H2 isolates fell into the same cluster and they were grouped together with isolates found previously in different vegetables, ornamentals, and weeds. When NSm ORF was analyzed, the tested isolates formed a separate cluster: H1 isolate showed the highest affinity with TSWV isolates infecting chrysanthemum and pepper plants, whereas H2 isolate was most closely related to other virus isolates found in sweet pepper and tomatoes. These results indicate that both isolates were reassortants between different virus isolates, and represented two novel genetic patterns of TSWV.

  19. I Still Haven't Found What I'm Looking For... Bono, Google and Glaucoma Awareness.

    Science.gov (United States)

    Lyons, C; Ellard, R; McElnea, E; Townley, D

    2017-05-10

    The effect of celebrity diagnosis on public awareness of health conditions has already been well documented. In October 2014, Bono, the lead singer with U2, revealed publicly for the first time that he has glaucoma. This study aimed to analyze the impact of Bono's announcement on public awareness of glaucoma using Google Search trends as an indicator of public interest in the disease. Google Trends was used to examine Google Search activity for the term 'Glaucoma' between 2009 and 2015 in both Ireland and the United Kingdom. Trend analyses were performed using Microsoft Excel Version 14.3.5. Increased Google Search activity for 'Glaucoma' in October 2014 was found in both Ireland and the United Kingdom. A five-fold increase from the mean Google Search activity for this term was found in Ireland and a two-fold increase from the mean Google Search activity for this term was found in the United Kingdom. No such increase in Google Search activity occurred during each country's 2014 Glaucoma Awareness week. Google Trends is useful in medical research as a means of assessing public awareness of, and/or interest in, health related topics. Current approaches to glaucoma related health promotion in both Ireland and the United Kingdom have failed to yield an increase in on-line Google Search activity. While there was an increase in interest in glaucoma it is unclear whether this led to an increase in health seeking behaviour.

  20. Deuterium Enrichment of Amino and Hydroxy Acids Found in the Murchison Meteorite: Constraints on Parent Body Conditions

    Science.gov (United States)

    Lerner, Narcinda R.; Chang, Sherwood (Technical Monitor)

    1997-01-01

    The alpha-amino and alpha-hydroxy acids found in the Murchison carbonaceous chondrite are deuterium enriched. These compounds are thought to have originated from common deuterium enriched carbonyl precursors, by way of a Strecker synthesis which took place in a solution of HCN, NH3, and carbonyl compounds during the period of aqueous alteration of the meteorite parent body. However, the hydroxy acids found on Murchison are less deuterium enriched than the amino acids. With the objective of determining if the discrepancy in deuterium enrichment between the amino acids and the hydroxy acids found on Murchison is consistent with their formation in a Strecker synthesis, we have measured the deuterium content of alpha-amino and alpha-hydroxy acids produced in solutions of deuterated carbonyl compounds, KCN and NH4Cl, and also in mixtures of such solutions and Allende dust at 263 K and 295 K. Retention of the isotopic signature of the starting carbonyl by both alpha amino acids and alpha hydroxy acids is more dependent upon temperature, concentration and pH than upon the presence of meteorite dust in the solution. The constraints these observations place on Murchison parent body conditions will be discussed.

  1. A novel archaeal group in the phylum Crenarchaeota found unexpectedly in an eukaryotic survey in the Cariaco Basin.

    Science.gov (United States)

    Jeon, Sun-Ok; Ahn, Tae-Seok; Hong, Sun-Hee

    2008-02-01

    Archaea have been found in many more diverse habitats than previously believed due in part to modern molecular approaches to discovering microbial diversity. We report here an unexpected expansion of the habitat diversity of the Archaea in the Cariaco Basin we found using a primer set designed for 18S eukaryotic rDNA sequence analysis. The results presented here expand the originally identified 9 archaeal clones reported in this environment using bacterial/archaeal primers to 152 archaeal clones: 67 (18 OTU) of these clones were found at a depth of 900 m of station A while 71 (9 OTU) of them were at a depth of between 300 approximately 335 m of station B&C depending upon which location the samples were taken. We used three phylogenetic analysis methods and detected 20 phylotypes belonging to a single previously unreported group distantly related to the Crenarchaeota. Also, we determined that the original nine sequences did not fall into any of the known phyla of the Archaea suggesting that they may represent a novel group within the Kingdom Archaea. Thus, from these two studies, we suggest that Archaea in the Cariaco Basin could be unique; however, further studies using archaeal-specific primers and the design of new primers as well as the systematic use of several different primer combinations may improve the chances of understanding the archeal diversity in the Cariaco Basin.

  2. Survey on plasticizers currently found in PVC toys on the Swiss market: Banned phthalates are only a minor concern.

    Science.gov (United States)

    McCombie, Gregor; Biedermann, Sandra; Suter, Gaby; Biedermann, Maurus

    2017-04-16

    Plasticizers in toys are a recurring source of criticism and concern, as consumers feel they may endanger the health of their children. Most of the information available in literature concerns the presence or absence of certain phthalic acid ester plasticizers. Very little information can be found in the public domain with respect to the actually used plasticizers at a given time and place. In this paper, we present the plasticizer composition of 118 samples from 88 polyvinyl chloride toys found on the Swiss market in autumn 2015. Bis(2-ethylhexyl) terephthalate (DEHT) was by far the most frequent main plasticizer in the analyzed samples, which is a change when compared to the plasticizers found in toys and child care articles in 2007. Furthermore, the data show that the banned phthalates in toys are only a minor concern. The occurrence, however, is not evenly distributed between importers. If a toy is not designed to be sold on the European market by the manufacturer, it seems to be more likely to contain a banned phthalic acid ester.

  3. Retrospective analyses of dogs found serologically positive for Ehrlichia canis in Cebu, Philippines from 2003 to 2014

    Directory of Open Access Journals (Sweden)

    Adrian P. Ybañez

    2016-01-01

    Full Text Available Aim: The study aimed to document the clinical and hematological observations of dogs found serologically positive for Ehrlichia canis and to identify parameters or factors that are associated with the disease with focus on the anemic and thrombocytopenic state of the infected dogs. Materials and Methods: From 7 participating veterinary establishments, a total of 913 cases from 2003 to 2014 were initially assessed using inclusion criteria, including E. canis diagnosis by the attending veterinarian and the presence of ticks or history of infestation, thrombocytopenia, and/or anemia. From these, 438 cases that were found serologically positive for E. canis using commercial test kits were selected. Profile, clinical observations and hematological test results were obtained from the selected cases. Computations for statistical associations between the anemic and thrombocytopenic state of the infected dogs and their profile, observed clinical signs and other hematological values were performed. Results: Most of the dogs were purebred (60.0% and female (51.1% and were within the age range of 1-5 years (38.4%. The mean packed cell volume (PCV, red blood cell (RBC count, and platelet count were lower than the normal values while the absolute count of basophils were higher than normal values. Creatinine and blood urea nitrogen (BUN appear to be elevated. The most common clinical signs observed were inappetence (41.3%, lethargy/depression (35.6%, vomiting (32.4%, fever (18.5%, paleness (8.2%, and epistaxis (6.6%. Analyses showed that there were no significant differences on the hematological values and clinical signs between thrombocytopenic and non-thrombocytopenic seropositive dogs. Moreover, very weak correlations between platelet count and RBC count, absolute lymphocyte count, and neutrophil count were found. On the other hand, only paleness (p=0.008 and epistaxis (p=0.004 were found to be significantly different between anemic and non-anemic patients

  4. Possible Origins of CTnBST, a Conjugative Transposon Found Recently in a Human Colonic Bacteroides Strain▿

    Science.gov (United States)

    Schlesinger, David J.; Shoemaker, Nadja B.; Salyers, Abigail A.

    2007-01-01

    A previous survey of Bacteroides isolates suggested that the ermB gene entered Bacteroides spp. recently. Previously, ermB had been found almost exclusively in gram-positive bacteria. In one Bacteroides strain, ermB was located on 100-kb conjugative transposon (CTn) CTnBST. To assess the possible origin of this CTn, we obtained the full DNA sequence of CTnBST and used this information to investigate its possible origins. Over one-half of CTnBST had high sequence identity to a putative CTn found in the genome of Bacteroides fragilis YCH46. This included the ends of the CTn and genes involved in integration, transfer, and excision. However, the region around the ermB gene contained genes that appeared to originate from gram-positive organisms. In particular, a 7-kb segment containing the ermB gene was 100% identical to an ermB region found in the genome of the gram-positive bacterium Arcanobacterium pyogenes. A screen of Bacteroides isolates whose DNA cross-hybridized with a CTnBST probe revealed that several isolates did not carry the 7-kb region, implying that the acquisition of this region may be more recent than the acquisition of the entire CTnBST element by Bacteroides spp. We have also identified other Bacteroides isolates that carry a slightly modified 7-kb region but have no other traces of CTnBST. Thus, it is possible that this 7-kb region could itself be part of a mobile element that has inserted in a Bacteroides CTn. Our results show that CTnBST is a hybrid element which has acquired a portion of its coding region from gram-positive bacteria but which may originally have come from Bacteroides spp. or some related species. PMID:17483268

  5. Possible origins of CTnBST, a conjugative transposon found recently in a human colonic Bacteroides strain.

    Science.gov (United States)

    Schlesinger, David J; Shoemaker, Nadja B; Salyers, Abigail A

    2007-07-01

    A previous survey of Bacteroides isolates suggested that the ermB gene entered Bacteroides spp. recently. Previously, ermB had been found almost exclusively in gram-positive bacteria. In one Bacteroides strain, ermB was located on 100-kb conjugative transposon (CTn) CTnBST. To assess the possible origin of this CTn, we obtained the full DNA sequence of CTnBST and used this information to investigate its possible origins. Over one-half of CTnBST had high sequence identity to a putative CTn found in the genome of Bacteroides fragilis YCH46. This included the ends of the CTn and genes involved in integration, transfer, and excision. However, the region around the ermB gene contained genes that appeared to originate from gram-positive organisms. In particular, a 7-kb segment containing the ermB gene was 100% identical to an ermB region found in the genome of the gram-positive bacterium Arcanobacterium pyogenes. A screen of Bacteroides isolates whose DNA cross-hybridized with a CTnBST probe revealed that several isolates did not carry the 7-kb region, implying that the acquisition of this region may be more recent than the acquisition of the entire CTnBST element by Bacteroides spp. We have also identified other Bacteroides isolates that carry a slightly modified 7-kb region but have no other traces of CTnBST. Thus, it is possible that this 7-kb region could itself be part of a mobile element that has inserted in a Bacteroides CTn. Our results show that CTnBST is a hybrid element which has acquired a portion of its coding region from gram-positive bacteria but which may originally have come from Bacteroides spp. or some related species.

  6. Risk Stratification of Thyroid Incidentalomas Found on PET/CT: The Value of Iodine Content on Noncontrast Computed Tomography.

    Science.gov (United States)

    Kim, Dongwoo; Hwang, Sang Hyun; Cha, Jongtae; Jo, Kwanhyeong; Lee, Narae; Yun, Mijin

    2015-11-01

    The Hounsfield unit (HU) ratio of thyroid nodules was assessed compared to the contralateral thyroid lobe on noncontrast computed tomography (CT) to stratify further the risk of malignancy in thyroid incidentalomas found on 18F-fluorodeoxyglucose ((18)F-FDG) positron emission tomography/CT (PET/CT). This retrospective analysis included 82 patients who had thyroid incidentalomas on PET/CT in 2011. On PET/CT, the maximal standardized uptake value ratios of the thyroid nodule compared to liver (T/BSUV) and the HU ratios of the thyroid nodule compared to contralateral thyroid lobe (T/BHU) were calculated. Diagnostic performances of the T/BSUV and T/BHU were compared. The area under the curve of T/BHU was higher than that of T/BSUV (0.941 vs. 0.689, p risk of malignancy was much higher (71.1%) in nodules with a T/BHU cutoff value ≤0.68, whereas it was 0% in nodules with a T/BHU of >0.68. In this study, there were 18 nodules with nondiagnostic (n = 7) or atypia of undetermined significance or follicular lesion of undetermined significance cytologies (n = 11) after fine-needle aspiration biopsy (FNAB). When the T/BHU cutoff value was applied, three (60%) of the five nodules with a T/BHU of ≤0.68 were found to be papillary carcinomas. The remaining 13 nodules with a T/BHU of >0.68 were all benign with a risk of malignancy of 0%. T/BHU is a simple and effective parameter to stratify the risk of malignancy in thyroid incidentalomas found on PET/CT. This may be of clinical relevance in those nodules with nondiagnostic or undetermined significance cytologies upon FNAB in the scheme of current clinical practice.

  7. The fungus Ustilago maydis and humans share disease-related proteins that are not found in Saccharomyces cerevisiae

    Directory of Open Access Journals (Sweden)

    Steinberg Gero

    2007-12-01

    Full Text Available Abstract Background The corn smut fungus Ustilago maydis is a well-established model system for molecular phytopathology. In addition, it recently became evident that U. maydis and humans share proteins and cellular processes that are not found in the standard fungal model Saccharomyces cerevisiae. This prompted us to do a comparative analysis of the predicted proteome of U. maydis, S. cerevisiae and humans. Results At a cut off at 20% identity over protein length, all three organisms share 1738 proteins, whereas both fungi share only 541 conserved proteins. Despite the evolutionary distance between U. maydis and humans, 777 proteins were shared. When applying a more stringent criterion (≥ 20% identity with a homologue in one organism over at least 50 amino acids and ≥ 10% less in the other organism, we found 681 proteins for the comparison of U. maydis and humans, whereas the both fungi share only 622 fungal specific proteins. Finally, we found that S. cerevisiae and humans shared 312 proteins. In the U. maydis to H. sapiens homology set 454 proteins are functionally classified and 42 proteins are related to serious human diseases. However, a large portion of 222 proteins are of unknown function. Conclusion The fungus U. maydis has a long history of being a model system for understanding DNA recombination and repair, as well as molecular plant pathology. The identification of functionally un-characterized genes that are conserved in humans and U. maydis opens the door for experimental work, which promises new insight in the cell biology of the mammalian cell.

  8. Antimicrobial peptides secreted by equine mesenchymal stromal cells inhibit the growth of bacteria commonly found in skin wounds.

    Science.gov (United States)

    Harman, Rebecca M; Yang, Steven; He, Megan K; Van de Walle, Gerlinde R

    2017-07-04

    The prevalence of chronic skin wounds in humans is high, and treatment is often complicated by the presence of pathogenic bacteria. Therefore, safe and innovative treatments to reduce the bacterial load in cutaneous wounds are needed. Mesenchymal stromal cells (MSC) are known to provide paracrine signals that act on resident skin cells to promote wound healing, but their potential antibacterial activities are not well described. The present study was designed to examine the antibacterial properties of MSC from horses, as this animal model offers a readily translatable model for MSC therapies in humans. Specifically, we aimed to (i) evaluate the in vitro effects of equine MSC on the growth of representative gram-negative and gram-positive bacterial species commonly found in skin wounds and (ii) define the mechanisms by which MSC inhibit bacterial growth. MSC were isolated from the peripheral blood of healthy horses. Gram-negative E. coli and gram-positive S. aureus were cultured in the presence of MSC and MSC conditioned medium (CM), containing all factors secreted by MSC. Bacterial growth was measured by plating bacteria and counting viable colonies or by reading the absorbance of bacterial cultures. Bacterial membrane damage was detected by incorporation of N-phenyl-1-naphthylamine (NPN). Antimicrobial peptide (AMP) gene and protein expression by equine MSC were determined by RT-PCR and Western blot analysis, respectively. Blocking of AMP activity of MSC CM was achieved using AMP-specific antibodies. We found that equine MSC and MSC CM inhibit the growth of E. coli and S. aureus, and that MSC CM depolarizes the cell membranes of these bacteria. In addition, we found that equine MSC CM contains AMPs, and blocking these AMPs with antibodies reduces the effects of MSC CM on bacteria. Our results demonstrate that equine MSC inhibit bacterial growth and secrete factors that compromise the membrane integrity of bacteria commonly found in skin wounds. We also identified

  9. Present at the creation: the founding and formative years of the Association of Academic Health Sciences Libraries.

    Science.gov (United States)

    Jacobson, Susan

    2003-04-01

    The Association of Academic Health Sciences Libraries (AAHSL) was founded in 1978 with the goal of strengthening academic health sciences libraries and increasing their participation nationally in efforts to improve medical education. A primary objective of the organization was to achieve a formal relationship with the Association of American Medical Colleges (AAMC) through membership in the Council of Academic Societies (CAS). Initial steps in establishing AAHSL are examined, including its efforts to join CAS. The author pays tribute to AAHSL's founders, in particular Gerald Oppenheimer, without whose vision and leadership AAHSL would not have been formed.

  10. Large amounts of marine debris found in sperm whales stranded along the North Sea coast in early 2016.

    Science.gov (United States)

    Unger, Bianca; Rebolledo, Elisa L Bravo; Deaville, Rob; Gröne, Andrea; IJsseldijk, Lonneke L; Leopold, Mardik F; Siebert, Ursula; Spitz, Jérôme; Wohlsein, Peter; Herr, Helena

    2016-11-15

    30 sperm whales (Physeter macrocephalus) stranded along the coasts of the North Sea between January and February 2016. The gastro-intestinal tracts of 22 of the carcasses were investigated. Marine debris including netting, ropes, foils, packaging material and a part of a car were found in nine of the 22 individuals. Here we provide details about the findings and consequences for the animals. While none of the items was responsible for the death of the animal, the findings demonstrate the high level of exposure to marine debris and associated risks for large predators, such as the sperm whale. Copyright © 2016 Elsevier Ltd. All rights reserved.

  11. Types of trematodes infecting freshwater snails found in irrigation canals in the East Nile locality, Khartoum, Sudan.

    Science.gov (United States)

    Mohammed, Nidal A I; Madsen, Henry; Ahmed, Abdel Aziz A R M

    2016-02-25

    The planorbid freshwater snails of the two genera, Biomphalaria and Bulinus -have been vigorously studied due to the role they play as intermediate hosts of schistosomiasis. In Sudan specifically, most studies have focused on the chemical and ecological control of the two genera, but few studies have looked at their biological control. This study explored the coexistence of other species of freshwater snails and the two genera along with their trematode infections in relation to a number of environmental factors in the East Nile locality, Khartoum state, Sudan. Freshwater snails from irrigation canals (abueshreens) were sampled monthly from January 2004 to December 2005. The snails were examined for trematode infections by cercarial emergence immediately after collection and then weekly for an additional four weeks to allow for the maturation of prepatent infections. Vegetation cover in the study sites as well as the physicochemical characteristics of the water, including temperature, were also recorded. A total of 10,493 snails, representing seven species, were collected. The most abundant species was Biomphalaria pfeifferi, representing 48.6 % of the sample. Overall, 14.1 % of the snails were found to be shedding some type of cercariae. Five species were found to have infections; among these the Bulinus truncatus species was found to be the most heavily infected, with an overall prevalence of 46.2 %. Double infections were recorded in only two B. truncatus snails and one Cleopatra bulimoides snail. Twenty different morphotypes of cercariae were recorded, seven of which appeared not to conform to previously described cercariae from Africa. Xiphidiocercariae type 1 was the most common type of cercariae recovered, accounting for 44.3 % of all infections. The density of snails tended to be lower during the summer months than the winter months, except for M. tuberculata snails, which were not affected by seasonal changes. The findings of this study indicate that

  12. Philophthalmus aweerensis n. sp. (Trematoda: Philophthalmidae) found in a rhea (Rhea americana) in the United Arab Emirates.

    Science.gov (United States)

    Schuster, Rolf K

    2011-10-01

    Philophthalmus aweerensis, a new eye fluke species, was discovered in the conjunctival cavities of a rhea in the UAE. This fluke was described and differentiated from other eye flukes that had been found in birds in the Middle East such as Philophthalmus palpebrarum, Philophthalmus nocturnus, Philophthalmus gralli, Philophthalmus lucipetus, Philophthalmus distomatosa, and Philophthalmus hegeneri. The new species lacks spination and is characterized by a long cirrus pouch extending behind the caudal margin of the acetabulum, long vitellaria of tubular type reaching the midbody, and a genital opening situated anteriorly to the bifurcation of the caeca.

  13. Novel anthraquinone derivatives produced by Phoma sorghina, an endophyte found in association with the medicinal plant Tithonia diversifolia (Asteraceae)

    Energy Technology Data Exchange (ETDEWEB)

    Borges, Warley de Souza; Pupo, Monica Tallarico [Sao Paulo Univ., Ribeirao Preto, SP (Brazil). Faculdade de Ciencias Farmaceuticas]. E-mail: mtpupo@fcfrp.usp.br

    2006-09-15

    Three known anthraquinones (1,7-dihydroxy-3-methyl-9,10-anthraquinone, 1,6-dihydroxy- 3-methyl-9,10-anthraquinone and 1-hydroxy-3-methyl-9,10-anthraquinone), one new anthraquinone (1,7-dihydroxy-3-hydroxymethyl-9,10-anthraquinone), and two new hexahydro anthraquinone derivatives, dendryols E and F, were isolated from the culture of the endophytic fungus Phoma sorghina, found in association with Tithonia diversifolia (Asteraceae). Their structures were identified on the basis of spectroscopic data, mainly 1D and 2D NMR. (author)

  14. Molecular and ultrastructural characterization of two ascomycetes found on sunken wood off Vanuatu islands in the deep Pacific ocean.

    Science.gov (United States)

    Dupont, Joëlle; Magnin, Sandrine; Rousseau, Florence; Zbinden, Magali; Frebourg, Ghislaine; Samadi, Sarah; de Forges, Bertrand Richer; Jones, E B Gareth

    2009-12-01

    A new genus of a deep-sea ascomycete with one new species, Alisea longicolla, is described based on analyses of 18S and 28S rDNA sequences and morphological characters. A. longicolla was found together with Oceanitis scuticella, on small twigs and sugar cane debris trawled from the bottom of the Pacific Ocean off Vanuatu Islands. Molecular and morphological characters indicate that both fungi are members of Halosphaeriaceae. Within this family, O. scuticella is phylogenetically related to Ascosalsum and shares similar ascospore morphology and appendage ontogeny. The genus Ascosalsum is considered congeneric with Oceanitis and Ascosalsum cincinnatulum, Ascosalsum unicaudatum and Ascosalsum viscidulum are transferred to Oceanitis, an earlier generic name.

  15. Stem loop sequences specific to transposable element IS605 are found linked to lipoprotein genes in Borrelia plasmids.

    Directory of Open Access Journals (Sweden)

    Nicholas Delihas

    Full Text Available BACKGROUND: Plasmids of Borrelia species are dynamic structures that contain a large number of repetitive genes, gene fragments, and gene fusions. In addition, the transposable element IS605/200 family, as well as degenerate forms of this IS element, are prevalent. In Helicobacter pylori, flanking regions of the IS605 transposase gene contain sequences that fold into identical small stem loops. These function in transposition at the single-stranded DNA level. METHODOLOGY/PRINCIPAL FINDINGS: In work reported here, bioinformatics techniques were used to scan Borrelia plasmid genomes for IS605 transposable element specific stem loop sequences. Two variant stem loop motifs are found in the left and right flanking regions of the transposase gene. Both motifs appear to have dispersed in plasmid genomes and are found "free-standing" and phylogenetically conserved without the associated IS605 transposase gene or the adjacent flanking sequence. Importantly, IS605 specific stem loop sequences are also found at the 3' ends of lipoprotein genes (PFam12 and PFam60, however the left and right sequences appear to develop their own evolutionary patterns. The lipoprotein gene-linked left stem loop sequences maintain the IS605 stem loop motif in orthologs but only at the RNA level. These show mutations whereby variants fold into phylogenetically conserved RNA-type stem loops that contain the wobble non-Watson-Crick G-U base-pairing. The right flanking sequence is associated with the family lipoprotein-1 genes. A comparison of homologs shows that the IS605 stem loop motif rapidly dissipates, but a more elaborate secondary structure appears to develop in its place. CONCLUSIONS/SIGNIFICANCE: Stem loop sequences specific to the transposable element IS605 are present in plasmid regions devoid of a transposase gene and significantly, are found linked to lipoprotein genes in Borrelia plasmids. These sequences are evolutionarily conserved and/or structurally developed in

  16. Changes of cellular superficial configuration of symbiotic algae during cultivation from two anemones found in the South China Sea

    Science.gov (United States)

    Zhu, Baohua; Pan, Kehou; Wang, Guangce

    2008-02-01

    Symbiotic algae from two anemones, Radianthus macrodactylus and Stichodactyla mertensii, found in the South China Sea, were cultivated in ASP-8A medium in this study. Changes of superficial configuration of symbiotic algae during the cultivation were studied by means of a microscope and a scanning electron microscope (SEM). A number of small cavities appeared on the surfaces of symbiotic algae after they were cultivated for 10 h. The cavities enlarged and the cell contents were lost with extended cultivation. Our data suggested that the presence of cavities on symbiotic algae surfaces may be one of the main reasons for failure to culture symbiotic algae in an artificial medium.

  17. Imported Items Found at the Uvek Site (Accidental Finds Kept at the Saratov Regional Museum of Local Lore

    Directory of Open Access Journals (Sweden)

    Kubankin Dmitriy A.

    2013-12-01

    Full Text Available A collection of 396 imported items found on the Uvek fortified settlement site as accidental discoveries is discussed in the article. Among them, the majority of ceramic products are mostly ceremonial utensils. Mirrors, jewelry, glass and metal vessels are also represented. Most finds relevant to external imports come from Iran, Byzantium, Trebizond, the Mamluk State, China and Central Asia (with the exception of Khwarezm. Domestic import is dominated by products from South-Eastern Crimea, Khwarezm and the Lower Volga area. The peak of trade routes development is dated by the period from the 1270s through to the 1330s.

  18. Structural and functional analyses of the DMC1-M200V polymorphism found in the human population

    OpenAIRE

    Hikiba, Juri; Hirota, Kouji; Kagawa, Waturu; Ikawa, Shukuko; Kinebuchi, Takashi; Sakane, Isao; Takizawa, Yoshimasa; Yokoyama, Shigeyuki; Mandon Pepin, Béatrice; Nicolas, Alain; Shibata, Takehiko; Ohta, Kunihiro; Kurumizaka, Hitoshi

    2008-01-01

    The M200V polymorphism of the human DMC1 protein, which is an essential, meiosis-specific DNA recombinase, was found in an infertile patient, raising the question of whether this homozygous human DMC1-M200V polymorphism may cause infertility by affecting the function of the human DMC1 protein. In the present study, we determined the crystal structure of the human DMC1-M200V variant in the octameric-ring form. Biochemical analyses revealed that the human DMC1-M200V variant had reduced stabilit...

  19. The first wolf found in the Netherlands in 150 years was the victim of a wildlife crime

    OpenAIRE

    Gravendeel, B.; Groot, De, Julie; Kik, M.; Beentjes, K.; Bergman, H.; Caniglia, R.; Cremers, H.; Fabbri, E.; D. Groenenberg; Grone, A; Groot Bruinderink, G.W.T.A.; Font, I.; Hakhof, J.; Harms, V.; Jansman, H.A.H.

    2013-01-01

    On July 4th 2013 a dead subadult female wolf-like canid was found by the roadside between Luttelgeest and Marknesse in the Noordoostpolder in the central part of the Netherlands. As the last observations of wild wolves in the Netherlands date back to 1869 the discovery of this animal generated a lot of media attention. European wolf populations have been expanding since the 1950s and the first packs recently established themselves in Germany in geographic proximity of the Dutch border, so nat...

  20. Trypanosoma cruzi isolated from a triatomine found in one of the biggest metropolitan areas of Latin America

    Directory of Open Access Journals (Sweden)

    Aline Rimoldi Ribeiro

    2016-04-01

    Full Text Available Abstract: INTRODUCTION: To characterize Trypanosoma cruzi (TcI isolated from a Panstrongylus megistus specimen found in one of the biggest metropolitan areas of Latin America, the relationship between the TcI group of T. cruzi and the transmission cycle in the urban environment was studied. METHODS: The T. cruzi strain, Pm, was isolated in a culture medium from the evolutionary forms present in the hindgut of a live male specimen of P. megistus found in the Jabaquara subway in São Paulo City. The sample from the triatomine showed trypomastigote forms of Trypanosomatidae, which were inoculated in the peritoneum of Balb/c mice. The sample was then inoculated in Liver Infusion Tryptose medium and J774 cells for the molecular identification and characterization of the parasite. The Pm strain of T. cruzi was identified by isolation in axenic culture medium, and based on the morphology, cell infection, growth kinetics, and molecular characterization. RESULTS: After isolation, the protozoan was identified as T. cruzi. No parasites were detected in the peripheral blood of the animal, which can be a characteristic inherent to the strain of T. cruzi that was isolated. Cell invasion assays were performed in triplicate in the J774 cell line to confirm the invasive ability of the Pm strain and revealed amastigote forms of the parasite within macrophages. CONCLUSIONS: Our biological and molecular characterizations helped understand parasite-host interactions and their evolutionary history in context of the associations between vectors, ecotopes, hosts, and groups of the parasite.

  1. Non-neoplastic lesions found only in the two-year bioassays but not in shorter toxicity studies of rats.

    Science.gov (United States)

    Nonaka, Mizuho; Amakasu, Kouhei; Saegusa, Yukie; Naota, Misaki; Nishimura, Takuya; Ogawa, Kumiko; Nishikawa, Akiyoshi

    2017-06-01

    International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) has been conducting a prospective evaluation period to validate the criteria for waiving some carcinogenicity studies in rats. Before the waiving strategy is practiced in ICH, it is crucial to elucidate whether non-neoplastic lesions are found only in 2-year rat carcinogenicity studies. To confirm possible importance of 2-year bioassays for evaluating chronic toxicity but not carcinogenicity, we retrospectively surveyed 59 pharmaceuticals approved by the Ministry of Health, Labour and Welfare (MHLW) from 2007 to 2010 in Japan for non-neoplastic lesions observed in carcinogenicity studies. Non-neoplastic histopathological lesions observed only in 2-year carcinogenicity studies but not in 6-month chronic toxicity studies using rats were compared with clinical adverse drug reactions (ADRs). Thirteen non-neoplastic lesions that may correlate with clinical ADRs were classified into three categories: Category 1, lesions not predictable from other nonclinical data except those from 2-year rat carcinogenicity studies; Category 2, lesions predictable mainly from chronic toxicity studies; Category 3, lesions predictable mainly from pharmacological actions. In the present survey, non-neoplastic lesions only found in 2-year rat carcinogenicity studies were neither significant in terms of frequency and severity nor useful for clinical risk management. Copyright © 2017 Elsevier Inc. All rights reserved.

  2. The behavioral changes that can be realized when leaders are exposed to the theories and metaphors found in quantum physics

    Science.gov (United States)

    Godfrey, David Wayne

    Many are beginning to see the promise that the quantum world has offered those who manage and lead organizations (Wheatley, 1992; Zohar, 1997). The Newtonian world is one in which all "things" are reduced to their smallest parts, separated, divided, and analyzed with predictability, with complete control being the ultimate goal. The quantum world is one of infinite possibilities, infinite fields of influence, and infinite relationships. The hallmark characteristics found in a manager who has been schooled in the quantum sciences are flexibility, responsiveness, synchronicity, serendipity, creativity, innovation, participation, and motivation. In a quantum organization there is the constant awareness of the whole system, but there is also diversity (wave or particle), which allows for self-organization that is based on the environment and its requirements. In the quantum world many paths lead from A to Z, and depending on the path chosen, numerous realities wait to unfold. It was the goal of this research to explore the changing of leader behaviors through exposure to the models and theories found in quantum physics. From a quantum perspective this behavior change is possible; the only question is the readiness, willingness, and ability of the leaders to allow their behaviors to be surfaced and challenged. These are indeed the greatest challenges for all people as they proceed through life and work---readiness for change, willingness to change, and ability to surface key areas where change is needed.

  3. Collecting Duct Renal Cell Carcinoma Found to Involve the Collecting System During Partial Nephrectomy: A Case Report

    Directory of Open Access Journals (Sweden)

    Andrew C Harbin

    2015-06-01

    Full Text Available Collecting duct carcinoma (CDC is a rare and aggressive form of renal cell carcinoma (RCC arising from the principal cells of the collecting duct.  One third of cases present with metastatic disease, but many present in a manner similar to conventional RCC or urothelial carcinoma (UC.  We discuss a case of CDC which presented as a small mass at the cortico-medullary junction, and was discovered at robotic partial nephrectomy (RPN to be grossly involving the collecting system. A 62-year-old man presented with a small renal mass suspicious for RCC, which was found on computed tomography (CT after an episode of gross hematuria.  After thorough workup, RPN was attempted; however, intraoperatively the mass was found to be involving the collecting system.  Radical nephroureterectomy was performed, and the pathology report revealed CDC.  CDC is a rare and aggressive form of RCC.  While many cases are metastatic at diagnosis, most patients present with the incidental finding of a small renal mass.  There are no reports of a CDC involving the collecting system at RPN after negative ureteroscopy preoperatively.  The adjuvant therapeutic options for CDC are limited, and long term survival is poor.    

  4. Exposure of clownfish larvae to suspended sediment levels found on the Great Barrier Reef: Impacts on gill structure and microbiome.

    Science.gov (United States)

    Hess, Sybille; Wenger, Amelia S; Ainsworth, Tracy D; Rummer, Jodie L

    2015-06-22

    Worldwide, increasing coastal development has played a major role in shaping coral reef species assemblages, but the mechanisms underpinning distribution patterns remain poorly understood. Recent research demonstrated delayed development in larval fishes exposed to suspended sediment, highlighting the need to further understand the interaction between suspended sediment as a stressor and energetically costly activities such as growth and development that are essential to support biological fitness. We examined the gill morphology and the gill microbiome in clownfish larvae (Amphiprion percula) exposed to suspended sediment concentrations (using Australian bentonite) commonly found on the inshore Great Barrier Reef. The gills of larvae exposed to 45 mg L(-1) of suspended sediment had excessive mucous discharge and growth of protective cell layers, resulting in a 56% thicker gill epithelium compared to fish from the control group. Further, we found a shift from 'healthy' to pathogenic bacterial communities on the gills, which could increase the disease susceptibility of larvae. The impact of suspended sediments on larval gills may represent an underlying mechanism behind the distribution patterns of fish assemblages. Our findings underscore the necessity for future coastal development to consider adverse effects of suspended sediments on fish recruitment, and consequently fish populations and ecosystem health.

  5. Intriguing Dehydrated Phyllosilicates Found in an Unusual Clast in the LL3.15 Chondrite NWS6925

    Science.gov (United States)

    Johnson, Jessica M.; Zolensky, Michael E.; Chan, Queenie; Kring, David A.

    2016-01-01

    Meteorites provide us with valuable insights into the conditions of the early solar system. Collisions often occur in our solar system that can result in materials accreting to other bodies as foreign clasts. These foreign pieces may have multiple origins that can sometimes be easily identified as a particular type of meteorite. It is important to interpret the origins of these clasts in order to understand dynamics of the solar system, especially throughout its early history. The Nice Model, as modified, proposes a reordering of planetary orbits that is hypothesized to have triggered the Late Heavy Bombardment. Clasts found within meteorites that came from objects in the solar system not commonly associated as an impactor could be indicative of such an event suggested by the Nice Model. Impacts also redistribute material from one region of an asteroid to another, and so clasts are found that reveal portions of the geological history of a body that are not recorded by typical samples. These would be cognate clasts. The goal of this investigation was to examine meteorites that had particularly interesting foreign and cognate clasts enclosed in them. We focus here on an unusual clast located in the ordinary chondrite, NWA 6925. This is one of three clasts analyzed during the LPI summer internship of Jessica Johnson.

  6. "Lean not on your own understanding": Belief that morality is founded on divine authority and non-utilitarian moral judgments

    Directory of Open Access Journals (Sweden)

    Jared Piazza

    2013-11-01

    Full Text Available Recent research has shown that religious individuals are much more resistant to utilitarian modes of thinking than their less religious counterparts, but the reason for this is not clear. We propose that a meta-ethical belief that morality is rooted in inviolable divine commands (i.e., endorsement of Divine Command Theory may help explain this finding. We present a novel 20-item scale measuring a belief that morality is founded on divine authority. The scale shows good internal reliability and convergent and discriminant validity. Study 1 found that this scale fully mediated the relationship that various religiosity measures had with a deontological thinking style in our sample of American adults. It also accounted for the link between religiosity and social conservative values. Furthermore, the relationship between the scale and these outcome variables held after statistically controlling for variables related to actively open-minded thinking and the Big Five. Study 2 replicated the results using naturalistic moral dilemmas that placed deontological and utilitarian concerns in conflict, and showed that the results of Study 1 cannot be explained by differences in moral foundations (e.g., concern for authority more generally or differences in the perceived function of rules. Quite the contrary, endorsement of the divine origins of morality fully mediated the relationship religiosity had with the so-called ``binding'' foundations (i.e., Loyalty, Authority, and Sanctity. Our findings highlight the importance of meta-ethical beliefs for understanding individual differences in moral judgment.

  7. Enterobacterial Small Mobile Sequences Carry Open Reading Frames and are Found Intragenically—Evolutionary Implications for Formation of New Peptides

    Directory of Open Access Journals (Sweden)

    Nicholas Delihas

    2007-01-01

    Full Text Available Intergenic repeat units of 127-bp (RU-1 and 168-bp (RU-2, as well as a newly-found class of 103-bp (RU-3, represent small mobile sequences in enterobacterial genomes present in multiple intergenic regions. These repeat sequences display similarities to eukaryotic miniature inverted-repeat transposable elements (MITE. The RU mobile elements have not been reported to encode amino acid sequences. An in silico approach was used to scan genomes for location of repeat units. RU sequences are found to have open reading frames, which are present in annotated gene loci whereby the RU amino acid sequence is maintained. Gene loci that display repeat units include those that encode large proteins which are part of super families that carry conserved domains and those that carry predicted motifs such as signal peptide sequences and transmembrane domains. A putative exported protein in Y. pestis and a phylogenetically conserved putative inner membrane protein in Salmonella species represent some of the more interesting constructs. We hypothesize that a major outcome of RU open reading frame fusions is the evolutionary emergence of new proteins.

  8. Underestimation of language issues in frequently used accident investigation methods: a new taxonomy problem found in Dutch accident data.

    Science.gov (United States)

    Lindhout, P; van Gulijk, C; Ale, B J M

    2011-07-15

    A wide variety of methods exist in the field of accident investigation. The challenge to find the cause for each and every accident has perpetuated a complicated and fundamental debate. In spite of the different paradigms, the many branch specific investigation methods, decades of accumulated and documented accident investigation experience, the diversity in taxonomy of causal factors, and an increasing depth of general systematic analysis tools, there are still causal factors missing out. A recent study identifies language issues as an underestimated danger. Dutch Labour Inspectorate records identify procedures and communication as an important causal factor area for major accidents. Accident investigation method taxonomies that are frequently used in The Netherlands, were investigated on the content related to language issues. Language issues are found to be either present less than proportional with observed accident rates or not present at all in frequently applied accident investigation classification systems. Hence a new taxonomy problem was found in Dutch accident data. Language issues need more attention in accident investigation methods. Copyright © 2011 Elsevier B.V. All rights reserved.

  9. On the astronomical origin of the Hallstatt oscillation found in radiocarbon and climate records throughout the Holocene

    CERN Document Server

    Scafetta, Nicola; Bianchini, Antonio; Ortolani, Sergio

    2016-01-01

    An oscillation with a period of about 2100-2500 years, the Hallstatt cycle, is found in cosmogenic radioisotopes (C-14 and Be-10) and in paleoclimate records throughout the Holocene. Herein we demonstrate the astronomical origin of this cycle. Namely, this oscillation is coherent to the major stable resonance involving the four Jovian planets - Jupiter, Saturn, Uranus and Neptune - whose period is p=2318 yr. The Hallstatt cycle could derive from the rhythmic variation of the circularity of the solar system disk assuming that this dynamics could eventually modulate the solar wind and, consequently, the incoming cosmic ray flux and/or the interplanetary/cosmic dust concentration around the Earth-Moon system. The orbit of the planetary mass center (PMC) relative to the Sun is used as a proxy. We analyzed how the instantaneous eccentricity vector of this virtual orbit varies from 13,000 B. C. to 17,000 A. D.. We found that it undergoes kind of pulsations as it clearly presents rhythmic contraction and expansion p...

  10. Characterisation of an enamelled metallic object found in Guerrero Negro (Baja California) by PIXE and RBS techniques

    Energy Technology Data Exchange (ETDEWEB)

    Calvo del Castillo, H. [Departamento de Geologia y Geoquimica, Universidad Autonoma de Madrid (Spain); Instituto de Fisica, Universidad Nacional Autonoma de Mexico (Mexico); Centre Europeen d' Archeometrie - I.P.N.A.S., Universite de Liege, Allee du 6 Aout, 10 Bat-15, Sart Tilman, 4000-Liege 1 (Belgium)], E-mail: hcalvo@ulg.ac.be; Ruvalcaba, J.L. [Instituto de Fisica, Universidad Nacional Autonoma de Mexico (Mexico); Calderon, T. [Departamento de Geologia y Geoquimica, Universidad Autonoma de Madrid (Spain); Salinas Nolasco, M.F. [Coordinacion de Conservacion del Patrimonio Cultural, Instituto Nacional de Antropologia e Historia (Mexico); Mejia, L.M. [Direccion de Arqueologia Subacuatica, Instituto Nacional de Antropologia e Historia (Mexico); Perdigon, K. [Coordinacion de Conservacion del Patrimonio Cultural, Instituto Nacional de Antropologia e Historia (Mexico)

    2008-05-15

    The coast of Guerrero Negro (Baja California) has been known for a long time by archaeologists for its shipwrecks. Archaeologists are recovering objects that come from sunken Spanish galleons in the colonial period, and reach the American coast in the frontier of the USA with Mexico. An enamelled metallic object was found next to the beach in Guerrero Negro. We have analysed the piece with proton induced X-ray emission (PIXE) and Rutherford backscattering (RBS) in an attempt to establish whether the object could come from one of the colonial shipwrecks and to valuate its cleaning process. Scanning electron microscopy (SEM) and energy dispersive X-ray spectrometry (EDS) have been also performed in three samples taken from the object in order to observe the heterogeneity of the material. The materials found revealed the presence of typical lead-glass enamels from with pigments such as cuprite (red), or lead-tin yellow used in colonial times. The metallic part consisted of brass. As for the cleaning process, the average efficiency considered as the weight% of chlorine removed, was of 83.4% for brass and 100% for ename0008.

  11. Two tickets to paradise: multiple dispersal events in the founding of hoary bat populations in Hawai'i

    Science.gov (United States)

    Russell, Amy L.; Pinzari, Corinna A.; Vonhof, Maarten J.; Olival, Kevin J.; Bonaccorso, Frank

    2015-01-01

    The Hawaiian islands are an extremely isolated oceanic archipelago, and their fauna has long served as models of dispersal in island biogeography. While molecular data have recently been applied to investigate the timing and origin of dispersal events for several animal groups including birds, insects, and snails, these questions have been largely unaddressed in Hawai'i's only native terrestrial mammal, the Hawaiian hoary bat, Lasiurus cinereus semotus. Here, we use molecular data to test the hypotheses that (1) Hawaiian L. c. semotus originated via dispersal from North American populations of L. c. cinereus rather than from South American L. c. villosissimus, and (2) modern Hawaiian populations were founded from a single dispersal event. Contrary to the latter hypothesis, our mitochondrial data support a biogeographic history of multiple, relatively recent dispersals of hoary bats from North America to the Hawaiian islands. Coalescent demographic analyses of multilocus data suggest that modern populations of Hawaiian hoary bats were founded no more than 10 kya. Our finding of multiple evolutionarily significant units in Hawai'i highlights information that should be useful for re-evaluation of the conservation status of hoary bats in Hawai'i.

  12. Remediating Past Images. The Temporality of “Found Footage” in Gábor Bódy’s American Torso

    Directory of Open Access Journals (Sweden)

    Pieldner Judit

    2014-09-01

    Full Text Available Along Laura U. Marks’s thoughts on the “disappearing image” as embodied experience, the article proposes to bring into discussion particular modes of occurrence of “past images,” whether in form of the use of archival/found footage or of creating visual archaisms in the spirit of archival recordings, within the practice of the Hungarian experimental film making of the 1970s and 1980s, more speciflcally, in Gábor Bódy’s films. The return to archival/found footage as well as the production of visual archaisms reveal an attempt of remediation (Bolter and Grusin that goes beyond the cultural responsibility of preservation: it confronts the film medium with its materiality, historicity, and temporality, and creates productive tensions between the private and the historical, between the pre-cinematic and the texture of motion pictures, between the documentary value of the image and its rhetorical dimension. The paper argues that the authenticity of the moving image in Gábor Bódy’s American Torso (Amerikai anzix, 1975 is achieved through a special combination of the immediacy and the hypermediacy of experience. Bódy’s interest in “past images” goes beyond the intention of experimentation with the medium; it is aimed at a profound, reconsidered archaeology of the image and a distinct sensing of the cinema.

  13. Small mammals found in discarded bottles in alpine and pre-alpine areas of NW-Italy

    Directory of Open Access Journals (Sweden)

    Paolo Debernardi

    1997-12-01

    Full Text Available Abstract 189 bottles and 6 cans, containing the remains of 904 small mammals were collected in alpine and pre-alpine areas of Piedmont, Aosta Valley and Lombardy. The following taxa were recorded: Sorex alpinus, Sorex araneus, Sorex minutus, Neomys fodiens, Crocidura leucodon, Crocidura suaveolens, Eliomys quercinus, Clethrionomys glareolus, Microtus arvalis, Microtus multiplex/subterraneus, Microtus savii, Chionomys nivalis, Apodemus spp., Mus domesticus, Soricidae was the best represented family in the sample (73.5% of the specimens found, with a different occurrence of Crocidurinae and Soricinae in xerothermic and non-xerothermic areas.

  14. High-Entropy Alloys: A Current Evaluation of Founding Ideas and Core Effects and Exploring "Nonlinear Alloys"

    Science.gov (United States)

    Miracle, Daniel B.

    2017-11-01

    The burgeoning field of high-entropy alloys (HEAs) is underpinned by two foundational concepts, and early research has been motivated by several hypotheses known as "core effects." The field is now entering its teenage years, and sufficient data have been collected to evaluate these hypotheses and to take a fresh look at the foundational concepts. Although recent assessments have concluded that two of the four HEA hypotheses are not supported by available data, new studies are already coming online to extend these analyses, and new interpretations are inspiring new directions for research within the field. This article gives an up-to-date evaluation of the HEA "core effects" and proposes "nonlinear alloys" as a new strategy to embrace the founding concept of compositional and microstructural vastness.

  15. ONGOING INVESTIGATION OF THE EFFECT THAT DRUGSTORE BEETLES HAVE ON CELOTEX ASSEMBLIES FOUND WITHIN RADIOACTIVE MATERIAL PACKAGINGS

    Energy Technology Data Exchange (ETDEWEB)

    Loftin, B.

    2009-06-08

    During normal operations at the Department of Energy's Hanford Site in Hanford, WA, drugstore beetles were found within the fiberboard subassemblies of two 9975 Shipping Packages. The Department of Energy's Packaging Certification Program (EM-60) directed a thorough investigation to determine if the drugstore beetles were causing damage that would be detrimental to the safety performance of the Celotex. The Savannah River National Laboratory is continuing to conduct the investigation with entomological expertise being provided by Clemson University. The outcome from the investigation conducted over the previous year was that no discernible damage had been caused by the drugstore beetles. One of the two packages has been essentially untouched over the past year and has only been opened to visually inspect for additional damage. This paper will provide details and results of the ongoing investigation of that package.

  16. [A hundred years since the founding of the pharmaceutical company "Salomon, Levin, Elshtein"--the origin of the TEVA Group].

    Science.gov (United States)

    Michlin, Amnon

    2002-09-01

    The Pharmaceutical trading company "Salomon Levin Elshtein", was founded one hundred years ago. It began in Jerusalem as a small store near the Old City walls, bought by brothers-in-law Haim Salomon (Yoel Moshe Salomon's son) and Moshe Gutel Levin. Among its first customers were the Jewish hospitals and local organizations of the Jewish settlements, who bought drugs for their pharmacies. In those days typical drugs in demand included quinine, for treating malaria and various fevers, and drugs against trachoma. In 1915 Israel Asher Elshtein joined the company, which subsequently changed its name to "Salomon Levin Elshtein" (SLE). Activities expanded and a branch opened in Jaffa. The pioneers of the pharmaceutical industry and various medical products in Israel eventually merged into the Teva Group.

  17. Larval stages of the bluefin tuna blood fluke Cardicola opisthorchis (Trematoda: Aporocotylidae) found from Terebella sp. (Polychaeta: Terebellidae).

    Science.gov (United States)

    Sugihara, Yukitaka; Yamada, Toshiyuki; Tamaki, Akio; Yamanishi, Ryohei; Kanai, Kinya

    2014-04-01

    We found aporocotylid larval stages (sporocysts and cercariae) from five individuals of terebellid polychaete Terebella sp., which were collected from seabed substrate and ropes and floats attached to tuna cages in a tuna farm on the coast of Tsushima Island, Nagasaki, Japan. Nucleotide sequences of the regions of internal transcribed spacer 2 ribosomal DNA and 28S ribosomal DNA from these larval stages were 100% identical to those of Cardicola opisthorchis registered in GenBank. C. opisthorchis is a pathogen causing blood fluke infection of Pacific bluefin tuna Thunnus orientalis, which is considered to have a significant impact on the Japanese Pacific bluefin tuna aquaculture industry. This is the first description of the intermediate host of C. opisthorchis. This indicates that the life cycle of C. opisthorchis is completed within tuna farms in this area. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  18. Primary follicular lymphoma of the spleen incidentally found in a patient with alcohol- and hepatitis C-related liver cirrhosis.

    Science.gov (United States)

    Matsuda, Ikuo; Okada, Masaya; Inoue, Takayuki; Tokugawa, Tazuko; Ogawa, Hiroyasu; Hirota, Seiichi

    2014-01-01

    Primary splenic lymphoma is rare as non-Hodgkin lymphomas. Splenic infiltration of lymphoma cells may cause splenomegaly in many cases. However, splenomegaly is caused not only by tumor involvement but also by non-tumorous disorders. One of the most prevalent non-neoplastic causes is portal hypertension mostly due to liver cirrhosis. On the other hand, liver cirrhosis may underlie various extrahepatic manifestations including development of B-cell non-Hodgkin lymphomas. Here, we report a case of primary follicular lymphoma of the spleen in a patient with liver cirrhosis related to hepatitis C and alcohol. The lymphoma was incidentally found in an enlarged spleen resected palliatively to alleviate symptomatic pancytopenia of the patient. The main characteristic of our case is an incidental finding of a rare situation brought by careful pathological examination. Our case illustrates the importance to recognize a possibility of co-occurrence of chronic liver disease and extrahepatic lymphoma.

  19. Galilei's astronomical discoveries using the telescope and their evaluation found in a writing-calendar from 1611

    Science.gov (United States)

    Herbst, K.-D.

    2009-06-01

    Yearly calendars were a mass-produced article in early modern times and had an enormous importance in everyday life. Besides a first part, the Calendarium with the monthly tables, they contain a second part, the astrological Prognosticum. At first, the two parts were sold separately. In the second half of the 17th century, the parts were designed as a unity and sold together. The calendars in quart format contain texts which are so interesting that historical research should give them more consideration. Such a text is found, e.g., in the second part of the calendar for 1611, written by Paul Nagel, astronomer and rector of the school in Torgau. Nagel informs about Galilei's discoveries with the telescope. The (Latin) text was written in August 1610. This text is presented and put into perspective in the scientific debates of the time about the telescope as a new invention with consequences to philosophy.

  20. Epidemiology of enteric pathogens found in stool symptomatic patients selected in a northern Bari region population between 2000 and 2009

    Directory of Open Access Journals (Sweden)

    Maria Antonietta Distasi

    2011-06-01

    Full Text Available Enteritis occur primarily in children and elderly. In order to analyse the frequency of single specific causative agents of enteritis, 5072 stool cultures have been evaluated at the Andria Hospital laboratory from 2000 to 2009. Cultures for Salmonella, Shigella, Campylobacter were performed, and, on samples from children under 6 years old, testing for presence of Adenovirus and Rotavirus was carried out. After inoculation on specific media, bacterial identification was performed via the VITEK system (bioMérieux, supplemented by serological identification for Salmonella and Shigella.Virus detection was performed by DIARLEX Dasit system. During the study period, 716 (14.1% samples were found positive for the presence of pathogen microorganisms. In the trimesters from February to May and November to January viral etiology was prevalent, whereas the bacterial one prevailed from June to October. In addition, during 2009, an increase of Campylobacter isolates was observed, with consequent reduction of Salmonella isolates.