Remote Laser Diffraction PSD Analyzer

International Nuclear Information System (INIS)

Batcheller, Thomas Aquinas; Huestis, Gary Michael; Bolton, Steven Michael

2000-01-01

Particle size distribution (PSD) analysis of radioactive slurry samples were obtained using a modified ''off-the-shelf'' classical laser light scattering particle size analyzer. A Horiba Instruments Inc. Model La-300 PSD analyzer, which has a 0.1 to 600 micron measurement range, was modified for remote application in a ''hot cell'' (gamma radiation) environment. The general details of the modifications to this analyzer are presented in this paper. This technology provides rapid and simple PSD analysis, especially down in the fine and microscopic particle size regime. Particle size analysis of these radioactive slurries down in this smaller range was not achievable--making this technology far superior than the traditional methods used previously. Remote deployment and utilization of this technology is in an exploratory stage. The risk of malfunction in this radiation environment is countered by gaining of this tremendously useful fundamental engineering data. Successful acquisition of this data, in conjunction with other characterization analyses, provides important information that can be used in the myriad of potential radioactive waste management alternatives

Nuclear Fuels & Materials Spotlight Volume 5

International Nuclear Information System (INIS)

Petti, David Andrew

2016-01-01

As the nation's nuclear energy laboratory, Idaho National Laboratory brings together talented people and specialized nuclear research capability to accomplish our mission. This edition of the Nuclear Fuels and Materials Division Spotlight provides an overview of some of our recent accomplishments in research and capability development. These accomplishments include: • Evaluation and modeling of light water reactor accident tolerant fuel concepts • Status and results of recent TRISO-coated particle fuel irradiations, post-irradiation examinations, high-temperature safety testing to demonstrate the accident performance of this fuel system, and advanced microscopy to improve the understanding of fission product transport in this fuel system. • Improvements in and applications of meso and engineering scale modeling of light water reactor fuel behavior under a range of operating conditions and postulated accidents (e.g., power ramping, loss of coolant accident, and reactivity initiated accidents) using the MARMOT and BISON codes. • Novel measurements of the properties of nuclear (actinide) materials under extreme conditions, (e.g. high pressure, low/high temperatures, high magnetic field) to improve the scientific understanding of these materials. • Modeling reactor pressure vessel behavior using the GRIZZLY code. • New methods using sound to sense temperature inside a reactor core. • Improved experimental capabilities to study the response of fusion reactor materials to a tritium plasma. Throughout Spotlight, you'll find examples of productive partnerships with academia, industry, and government agencies that deliver high-impact outcomes. The work conducted at Idaho National Laboratory helps spur innovation in nuclear energy applications that drive economic growth and energy security. We appreciate your interest in our work here at Idaho National Laboratory, and hope that you find this issue informative.

Capping of the N-terminus of PSD-95 by calmodulin triggers its postsynaptic release

Science.gov (United States)

Zhang, Yonghong; Matt, Lucas; Patriarchi, Tommaso; Malik, Zulfiqar A; Chowdhury, Dhrubajyoti; Park, Deborah K; Renieri, Alessandra; Ames, James B; Hell, Johannes W

2014-01-01

Postsynaptic density protein-95 (PSD-95) is a central element of the postsynaptic architecture of glutamatergic synapses. PSD-95 mediates postsynaptic localization of AMPA receptors and NMDA receptors and plays an important role in synaptic plasticity. PSD-95 is released from postsynaptic membranes in response to Ca2+ influx via NMDA receptors. Here, we show that Ca2+/calmodulin (CaM) binds at the N-terminus of PSD-95. Our NMR structure reveals that both lobes of CaM collapse onto a helical structure of PSD-95 formed at its N-terminus (residues 1–16). This N-terminal capping of PSD-95 by CaM blocks palmitoylation of C3 and C5, which is required for postsynaptic PSD-95 targeting and the binding of CDKL5, a kinase important for synapse stability. CaM forms extensive hydrophobic contacts with Y12 of PSD-95. The PSD-95 mutant Y12E strongly impairs binding to CaM and Ca2+-induced release of PSD-95 from the postsynaptic membrane in dendritic spines. Our data indicate that CaM binding to PSD-95 serves to block palmitoylation of PSD-95, which in turn promotes Ca2+-induced dissociation of PSD-95 from the postsynaptic membrane. PMID:24705785

Structure of the first PDZ domain of human PSD-93

DEFF Research Database (Denmark)

Fiorentini, Monica; Nielsen, Ann Kallehauge; Kristensen, Ole

2009-01-01

The crystal structure of the PDZ1 domain of human PSD-93 has been determined to 2.0 A resolution. The PDZ1 domain forms a crystallographic trimer that is also predicted to be stable in solution. The main contributions to the stabilization of the trimer seem to arise from interactions involving...... the PDZ1-PDZ2 linker region at the extreme C-terminus of PDZ1, implying that the oligomerization that is observed is not of biological significance in full-length PSD-93. Comparison of the structures of the binding cleft of PSD-93 PDZ1 with the previously reported structures of PSD-93 PDZ2 and PDZ3...

On-orbit Status and Light Attenuation Behavior of the DAMPE-PSD

Science.gov (United States)

Li, Y.; Zhang, Y. P.; Zhang, Y. J.; Sun, Z. Y.; Yu, Y. H.; Dong, T. K.; Ma, P. X.; Wang, Y. P.; Yuan, Q.

2017-11-01

The DArk Matter Particle Explorer (DAMPE) is a high-resolution multi-purpose space-borne device for detecting the high-energy cosmic-rays like e±, γ-rays, protons, and heavy-ions, which was launched on 2015 December 17th. The Plastic Scintillator Detector (PSD) is the top-most sub-detector of DAMPE. The PSD is designed to measure the charge of incident high-energy particles, and to serve as a veto detector for discriminating γ-rays from the charged particles. In this paper, the on-orbit status of the PSD after launching in terms of high voltage (HV) and temperature stabilities is presented. The temperature and the HV variations of the PSD are less than 1°C and 0.5%, respectively. By using the on-orbit data, the attenuation lengths of PSD bars are obtained according to an empirical formula. A preliminary charge spectrum reconstructed from the X-layer of the PSD is obtained.

Nuclear Fuels & Materials Spotlight Volume 5

Energy Technology Data Exchange (ETDEWEB)

Petti, David Andrew [Idaho National Lab. (INL), Idaho Falls, ID (United States)

2016-10-01

As the nation's nuclear energy laboratory, Idaho National Laboratory brings together talented people and specialized nuclear research capability to accomplish our mission. This edition of the Nuclear Fuels and Materials Division Spotlight provides an overview of some of our recent accomplishments in research and capability development. These accomplishments include: • Evaluation and modeling of light water reactor accident tolerant fuel concepts • Status and results of recent TRISO-coated particle fuel irradiations, post-irradiation examinations, high-temperature safety testing to demonstrate the accident performance of this fuel system, and advanced microscopy to improve the understanding of fission product transport in this fuel system. • Improvements in and applications of meso and engineering scale modeling of light water reactor fuel behavior under a range of operating conditions and postulated accidents (e.g., power ramping, loss of coolant accident, and reactivity initiated accidents) using the MARMOT and BISON codes. • Novel measurements of the properties of nuclear (actinide) materials under extreme conditions, (e.g. high pressure, low/high temperatures, high magnetic field) to improve the scientific understanding of these materials. • Modeling reactor pressure vessel behavior using the GRIZZLY code. • New methods using sound to sense temperature inside a reactor core. • Improved experimental capabilities to study the response of fusion reactor materials to a tritium plasma. Throughout Spotlight, you'll find examples of productive partnerships with academia, industry, and government agencies that deliver high-impact outcomes. The work conducted at Idaho National Laboratory helps spur innovation in nuclear energy applications that drive economic growth and energy security. We appreciate your interest in our work here at Idaho National Laboratory, and hope that you find this issue informative.

Marshall Space Flight Center Propulsion Systems Department (PSD) Knowledge Management (KM) Initiative

Science.gov (United States)

Caraccioli, Paul; Varnedoe, Tom; Smith, Randy; McCarter, Mike; Wilson, Barry; Porter, Richard

2006-01-01

NASA Marshall Space Flight Center's Propulsion Systems Department (PSD) is four months into a fifteen month Knowledge Management (KM) initiative to support enhanced engineering decision making and analyses, faster resolution of anomalies (near-term) and effective, efficient knowledge infused engineering processes, reduced knowledge attrition, and reduced anomaly occurrences (long-term). The near-term objective of this initiative is developing a KM Pilot project, within the context of a 3-5 year KM strategy, to introduce and evaluate the use of KM within PSD. An internal NASA/MSFC PSD KM team was established early in project formulation to maintain a practitioner, user-centric focus throughout the conceptual development, planning and deployment of KM technologies and capabilities within the PSD. The PSD internal team is supported by the University of Alabama's Aging Infrastructure Systems Center of Excellence (AISCE), lntergraph Corporation, and The Knowledge Institute. The principle product of the initial four month effort has been strategic planning of PSD KNI implementation by first determining the "as is" state of KM capabilities and developing, planning and documenting the roadmap to achieve the desired "to be" state. Activities undertaken to suppoth e planning phase have included data gathering; cultural surveys, group work-sessions, interviews, documentation review, and independent research. Assessments and analyses have beon pedormed including industry benchmarking, related local and Agency initiatives, specific tools and techniques used and strategies for leveraging existing resources, people and technology to achieve common KM goals. Key findings captured in the PSD KM Strategic Plan include the system vision, purpose, stakeholders, prioritized strategic objectives mapped to the top ten practitioner needs and analysis of current resource usage. Opportunities identified from research, analyses, cultural1KM surveys and practitioner interviews include

Color homogeneity in LED spotlights

NARCIS (Netherlands)

Prins, C.R.

2013-01-01

Color variation in the light output of white LEDs is a common problem in LED lighting. We aim to design LED spotlights with a uniform color output while keeping the cost of the system low and the energy efficiency high. Therefore we design a special optic to eliminate the color variation of the LED.

The research of PSD location method in micro laser welding fields

Science.gov (United States)

Zhang, Qiue; Zhang, Rong; Dong, Hua

2010-11-01

In the field of micro laser welding, besides the special requirement in the parameter of lasers, the locating in welding points accurately is very important. The article adopt position sensitive detector (PSD) as hard core, combine optic system, electric circuits and PC and software processing, confirm the location of welding points. The signal detection circuits adopt the special integrate circuit H-2476 to process weak signal. It is an integrated circuit for high-speed, high-sensitivity optical range finding, which has stronger noiseproof feature, combine digital filter arithmetic, carry out repair the any non-ideal factors, increasing the measure precision. The amplifier adopt programmable amplifier LTC6915. The system adapt two dimension stepping motor drive the workbench, computer and corresponding software processing, make sure the location of spot weld. According to different workpieces to design the clamps. The system on-line detect PSD 's output signal in the moving processing. At the workbench moves in the X direction, the filaments offset is detected dynamic. Analyze the X axes moving sampling signal direction could be estimate the Y axes moving direction, and regulate the Y axes moving values. The workbench driver adopt A3979, it is a stepping motor driver with insert transducer and operate easily. It adapts the requirement of location in micro laser welding fields, real-time control to adjust by computer. It can be content up 20 μm's laser micro welding requirement on the whole. Using laser powder cladding technology achieve inter-penetration welding of high quality and reliability.

A low cost PSD-based monocular motion capture system

Science.gov (United States)

Ryu, Young Kee; Oh, Choonsuk

2007-10-01

This paper describes a monocular PSD-based motion capture sensor to employ with commercial video game systems such as Microsoft's XBOX and Sony's Playstation II. The system is compact, low-cost, and only requires a one-time calibration at the factory. The system includes a PSD(Position Sensitive Detector) and active infrared (IR) LED markers that are placed on the object to be tracked. The PSD sensor is placed in the focal plane of a wide-angle lens. The micro-controller calculates the 3D position of the markers using only the measured intensity and the 2D position on the PSD. A series of experiments were performed to evaluate the performance of our prototype system. From the experimental results we see that the proposed system has the advantages of the compact size, the low cost, the easy installation, and the high frame rates to be suitable for high speed motion tracking in games.

TrkB and PKMζ regulate synaptic localization of PSD-95 in developing cortex

Science.gov (United States)

Yoshii, Akira; Murata, Yasunobu; Kim, Jihye; Zhang, Chao; Shokat, Kevan M.; Constantine-Paton, Martha

2011-01-01

Post-synaptic density 95 (PSD-95), the major scaffold at excitatory synapses, is critical for synapse maturation and learning. In rodents, eye opening, the onset of pattern vision, triggers a rapid movement of PSD-95 from visual neuron somata to synapses. We previously showed that the PI3 kinase-Akt pathway downstream of BDNF/TrkB signaling stimulates synaptic delivery of PSD-95 via vesicular transport. However, vesicular transport requires PSD-95 palmitoylation to attach it to a lipid membrane. Also PSD-95 insertion at synapses is known to require this lipid modification. Here, we show that BDNF/TrkB signaling is also necessary for PSD-95 palmitoylation and its transport to synapses in mouse visual cortical layer 2/3 neurons. However, palmitoylation of PSD-95 requires the activation of another pathway downstream of BDNF/TrkB, namely signaling through PLCγ and the brain-specific PKC variant PKMζ. We find that PKMζ selectively regulates phosphorylation of the palmitoylation enzyme ZDHHC8. Inhibition of PKMζ results in a reduction of synaptic PSD-95 accumulation in vivo, which can be rescued by over-expression ZDHHC8. Therefore, TrkB and PKMζ, two critical regulators of synaptic plasticity, facilitate PSD-95 targeting to synapses. These results also indicate that palmitoylation can be regulated by a trophic factor. Our findings have implications for neurodevelopmental disorders as well as ageing brains. PMID:21849550

COSMO-SkyMed Spotlight interometry over rural areas: the Slumgullion landslide in Colorado, USA

Science.gov (United States)

Milillo, Pietro; Fielding, Eric J.; Schulz, William H.; Delbridge, Brent; Burgmann, Roland

2014-01-01

In the last 7 years, spaceborne synthetic aperture radar (SAR) data with resolution of better than a meter acquired by satellites in spotlight mode offered an unprecedented improvement in SAR interferometry (InSAR). Most attention has been focused on monitoring urban areas and man-made infrastructure exploiting geometric accuracy, stability, and phase fidelity of the spotlight mode. In this paper, we explore the potential application of the COSMO-SkyMed® Spotlight mode to rural areas where decorrelation is substantial and rapidly increases with time. We focus on the rapid repeat times of as short as one day possible with the COSMO-SkyMed® constellation. We further present a qualitative analysis of spotlight interferometry over the Slumgullion landslide in southwest Colorado, which moves at rates of more than 1 cm/day.

Scientist Spotlight Homework Assignments Shift Students’ Stereotypes of Scientists and Enhance Science Identity in a Diverse Introductory Science Class

Science.gov (United States)

Schinske, Jeffrey N.; Perkins, Heather; Snyder, Amanda; Wyer, Mary

2016-01-01

Research into science identity, stereotype threat, and possible selves suggests a lack of diverse representations of scientists could impede traditionally underserved students from persisting and succeeding in science. We evaluated a series of metacognitive homework assignments (“Scientist Spotlights”) that featured counterstereotypical examples of scientists in an introductory biology class at a diverse community college. Scientist Spotlights additionally served as tools for content coverage, as scientists were selected to match topics covered each week. We analyzed beginning- and end-of-course essays completed by students during each of five courses with Scientist Spotlights and two courses with equivalent homework assignments that lacked connections to the stories of diverse scientists. Students completing Scientist Spotlights shifted toward counterstereotypical descriptions of scientists and conveyed an enhanced ability to personally relate to scientists following the intervention. Longitudinal data suggested these shifts were maintained 6 months after the completion of the course. Analyses further uncovered correlations between these shifts, interest in science, and course grades. As Scientist Spotlights require very little class time and complement existing curricula, they represent a promising tool for enhancing science identity, shifting stereotypes, and connecting content to issues of equity and diversity in a broad range of STEM classrooms. PMID:27587856

Scientist Spotlight Homework Assignments Shift Students' Stereotypes of Scientists and Enhance Science Identity in a Diverse Introductory Science Class.

Science.gov (United States)

Schinske, Jeffrey N; Perkins, Heather; Snyder, Amanda; Wyer, Mary

2016-01-01

Research into science identity, stereotype threat, and possible selves suggests a lack of diverse representations of scientists could impede traditionally underserved students from persisting and succeeding in science. We evaluated a series of metacognitive homework assignments ("Scientist Spotlights") that featured counterstereotypical examples of scientists in an introductory biology class at a diverse community college. Scientist Spotlights additionally served as tools for content coverage, as scientists were selected to match topics covered each week. We analyzed beginning- and end-of-course essays completed by students during each of five courses with Scientist Spotlights and two courses with equivalent homework assignments that lacked connections to the stories of diverse scientists. Students completing Scientist Spotlights shifted toward counterstereotypical descriptions of scientists and conveyed an enhanced ability to personally relate to scientists following the intervention. Longitudinal data suggested these shifts were maintained 6 months after the completion of the course. Analyses further uncovered correlations between these shifts, interest in science, and course grades. As Scientist Spotlights require very little class time and complement existing curricula, they represent a promising tool for enhancing science identity, shifting stereotypes, and connecting content to issues of equity and diversity in a broad range of STEM classrooms. © 2016 J. N. Schinske et al. CBE—Life Sciences Education © 2016 The American Society for Cell Biology. This article is distributed by The American Society for Cell Biology under license from the author(s). It is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

Psd1 Effects on Candida albicans Planktonic Cells and Biofilms

Directory of Open Access Journals (Sweden)

Sónia Gonçalves

2017-06-01

Full Text Available Candida albicans is an important human pathogen, causing opportunistic infections. The adhesion of planktonic cells to a substrate is the first step for biofilm development. The antimicrobial peptide (AMP Psd1 is a defensin isolated from Pisum sativum seeds. We tested the effects of this AMP on C. albicans biofilms and planktonic cells, comparing its activity with amphotericin B and fluconazole. Three C. albicans variants were studied, one of them a mutant deficient in glucosylceramide synthase, conferring resistance to Psd1 antifungal action. Atomic force microscopy (AFM was used to assess morphological and biomechanical changes on fungal cells. Surface alterations, with membrane disruption and leakage of cellular contents, were observed. Cytometry assays and confocal microscopy imaging showed that Psd1 causes cell death, in a time and concentration-dependent manner. These results demonstrate Psd1 pleiotropic action against a relevant fungal human pathogen, suggesting its use as natural antimycotic agent.

Maximum Likelihood PSD Estimation for Speech Enhancement in Reverberation and Noise

DEFF Research Database (Denmark)

Kuklasinski, Adam; Doclo, Simon; Jensen, Søren Holdt

2016-01-01

In this contribution we focus on the problem of power spectral density (PSD) estimation from multiple microphone signals in reverberant and noisy environments. The PSD estimation method proposed in this paper is based on the maximum likelihood (ML) methodology. In particular, we derive a novel ML...... instrumental measures and is shown to be higher than when the competing estimator is used. Moreover, we perform a speech intelligibility test where we demonstrate that both the proposed and the competing PSD estimators lead to similar intelligibility improvements......., it is shown numerically that the mean squared estimation error achieved by the proposed method is near the limit set by the corresponding Cram´er-Rao lower bound. The speech dereverberation performance of a multi-channel Wiener filter (MWF) based on the proposed PSD estimators is measured using several...

Diarrhea & Child Care: Controlling Diarrhea in Out-of-Home Child Care. NCEDL Spotlights, No. 4.

Science.gov (United States)

Churchill, Robin B.; Pickering, Larry K.

This report, the fourth in the National Center for Early Development and Learning's (NCEDL) "Spotlights" series, is based on excerpts from a paper presented during a "Research into Practice in Infant/Toddler Care" synthesis conference in fall 1997. The report addresses controlling diarrhea in out-of-home child care. The report…

VID22 is required for transcriptional activation of the PSD2 gene in the yeast Saccharomyces cerevisiae.

Science.gov (United States)

Miyata, Non; Miyoshi, Takuya; Yamaguchi, Takanori; Nakazono, Toshimitsu; Tani, Motohiro; Kuge, Osamu

2015-12-15

Phosphatidylethanolamine (PE) in the yeast Saccharomyces cerevisiae is synthesized through decarboxylation of phosphatidylserine (PS), catalysed by PS decarboxylase 1 (Psd1p) and 2 (Psd2p) and the cytidine 5'-diphosphate (CDP)-ethanolamine (CDP-Etn) pathway. PSD1 null (psd1Δ) and PSD2 null (psd2Δ) mutants are viable in a synthetic minimal medium, but a psd1Δ psd2Δ double mutant exhibits Etn auxotrophy, which is incorporated into PE through the CDP-Etn pathway. We have previously shown that psd1Δ is synthetic lethal with deletion of VID22 (vid22Δ) [Kuroda et al. (2011) Mol. Microbiol. 80: , 248-265]. In the present study, we found that vid22Δ mutant exhibits Etn auxotrophy under PSD1-depressed conditions. Deletion of VID22 in wild-type and PSD1-depressed cells caused partial defects in PE formation through decarboxylation of PS. The enzyme activity of PS decarboxylase in an extract of vid22Δ cells was ∼70% of that in wild-type cells and similar to that in psd2Δ cells and the PS decarboxylase activity remaining in the PSD1-depressed cells became almost negligible with deletion of VID22. Thus, the vid22Δ mutation was suggested to cause a defect in the Psd2p activity. Furthermore, vid22Δ cells were shown to be defective in expression of the PSD2 gene tagged with 6×HA, the defect being ameliorated by replacement of the native promoter of the PSD2 gene with a CYC1 promoter. In addition, an α-galactosidase reporter assay revealed that the activity of the promoter of the PSD2 gene in vid22Δ cells was ∼5% of that in wild-type cells. These results showed that VID22 is required for transcriptional activation of the PSD2 gene. © 2015 Authors; published by Portland Press Limited.

Holding a spotlight to an ageing society.

Science.gov (United States)

Cann, Paul

2008-07-01

In May 2008 Help the Aged published its 3rd annual Spotlight Report. The report highlights the stark realities facing older people in the UK today and gives detailed statistical data on how the lives of some have improved but many are still being left behind.

PSD Determination - Baseline

Science.gov (United States)

This document may be of assistance in applying the New Source Review (NSR) air permitting regulations including the Prevention of Significant Deterioration (PSD) requirements. This document is part of the NSR Policy and Guidance Database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

PSD Increment Baseline

Science.gov (United States)

This document may be of assistance in applying the New Source Review (NSR) air permitting regulations including the Prevention of Significant Deterioration (PSD) requirements. This document is part of the NSR Policy and Guidance Database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

The investigation of fatigue load on a PSD using finite element method

Energy Technology Data Exchange (ETDEWEB)

Choi, Mood Duck; Cho, Chong Du; Choi, Won June [Inha Univ., Incheon (Korea, Republic of); Kim, Jung Yup [Korea Institute of Construction Technology, Goyang (Korea, Republic of)

2008-07-01

Subway railway systems are being increasingly adopted in metro cities to ease the passenger transportation. But there are some concerns related to the safety of the passengers. Nowadays, PSD(Platform Screen Doors) are commonly used to assure the safety of passengers. PSD is used to prevent the fire disasters, air turbulence, and dust which may pose a threat to the passenger's safety. Moreover the design of PSD itself has to take some parameters into consideration, crowd loading, wind pressure, etc. In our present study we perform a fatigue analysis considering these parameters. Commercial finite element software package ANSYS Workbench 11.0 has been used for the structural analysis. In correlation with this analysis, the structural safety of the testing PSD equipment was confirmed, and the critical load condition was found.

The investigation of fatigue load on a PSD using finite element method

International Nuclear Information System (INIS)

Choi, Mood Duck; Cho, Chong Du; Choi, Won June; Kim, Jung Yup

2008-01-01

Subway railway systems are being increasingly adopted in metro cities to ease the passenger transportation. But there are some concerns related to the safety of the passengers. Nowadays, PSD(Platform Screen Doors) are commonly used to assure the safety of passengers. PSD is used to prevent the fire disasters, air turbulence, and dust which may pose a threat to the passenger's safety. Moreover the design of PSD itself has to take some parameters into consideration, crowd loading, wind pressure, etc. In our present study we perform a fatigue analysis considering these parameters. Commercial finite element software package ANSYS Workbench 11.0 has been used for the structural analysis. In correlation with this analysis, the structural safety of the testing PSD equipment was confirmed, and the critical load condition was found

Data acquisition system for linear PSD based neutron diffractometer

International Nuclear Information System (INIS)

Pande, S.S.; Borkar, S.P.; Behere, Anita; Ghodgaonkar, M.D.

2001-01-01

Single or multi-PSD configurations are used in different neutron diffractometer setups. A data acquisition system is developed to serve the gross requirements of all the diffractometer setups. It is also customized to specific requirements of different setups. The hardware is developed as a Transputer based add-on card. Most of the hardware functionality is handled in the Transputer program thus improving throughput of the system. The card can handle 16 RDCs, a few motor controls and on/off controls. The software comprises of a front-end Windows98 application, a Transputer program and a device driver. The data acquisition system performs data acquisition, analysis, display and storage. Analysis includes converting raw data of linear PSD to equiangular format, merging and clubbing the data to make a continuous equiangular spectrum. Calibration of individual PSD is a crucial activity in correctly merging the data coming from PSDs. (author)

Scientist Spotlight Homework Assignments Shift Students' Stereotypes of Scientists and Enhance Science Identity in a Diverse Introductory Science Class

Science.gov (United States)

Schinske, Jeffrey N.; Perkins, Heather; Snyder, Amanda; Wyer, Mary

2016-01-01

Research into science identity, stereotype threat, and possible selves suggests a lack of diverse representations of scientists could impede traditionally underserved students from persisting and succeeding in science. We evaluated a series of metacognitive homework assignments ("Scientist Spotlights") that featured counterstereotypical…

Spotlight on Psoriasis: Preventing Patches of Itchy, Sore Skin

Science.gov (United States)

... Subscribe August 2016 Print this issue Spotlight on Psoriasis Preventing Patches of Itchy, Sore Skin En español ... Sun Damage Sun and Skin Wise Choices Avoid Psoriasis Triggers Factors that may trigger psoriasis or make ...

75 FR 70254 - PSD and Title V Permitting Guidance for Greenhouse Gases

Science.gov (United States)

2010-11-17

... Guidance for Greenhouse Gases AGENCY: Environmental Protection Agency (EPA). ACTION: Notice of availability..., ``PSD and Title V Permitting Guidance for Greenhouse Gases'' on its significant guidance Internet Web... guidance titled, ``PSD and Title V Permitting Guidance for Greenhouse Gases.'' This document has been...

Neutron-gamma discrimination via PSD plastic scintillator and SiPMs

Science.gov (United States)

Taggart, M. P.; Payne, C.; Sellin, P. J.

2016-10-01

The reduction in availability and inevitable increase in cost of traditional neutron detectors based on the 3He neutron capture reaction has resulted in a concerted effort to seek out new techniques and detection media to meet the needs of national nuclear security. Traditionally, the alternative has been provided through pulse shape discrimination (PSD) using liquid scintillators. However, these are not without their own inherent issues, primarily concerning user safety and ongoing maintenance. A potential system devised to separate neutron and gamma ray pulses utilising the PSD technique takes advantage of recent improvements in silicon photomultiplier (SiPM) technology and the development of plastic scintillators exhibiting the PSD phenomena. In this paper we present the current iteration of this ongoing work having achieved a Figure of Merit (FoM) of 1.39 at 1.5 MeVee.

Multi-beam synchronous measurement based on PSD phase detection using frequency-domain multiplexing

Science.gov (United States)

Duan, Ying; Qin, Lan; Xue, Lian; Xi, Feng; Mao, Jiubing

2013-10-01

According to the principle of centroid measurement, position-sensitive detectors (PSD) are commonly used for micro displacement detection. However, single-beam detection method cannot satisfy such tasks as multi-dimension position measurement, three dimension vision reconstruction, and robot precision positioning, which require synchronous measurement of multiple light beams. Consequently, we designed PSD phase detection method using frequency-domain multiplexing for synchronous detection of multiple modulated light beams. Compared to previous PSD amplitude detection method, the phase detection method using FDM has advantages of simplified measuring system, low cost, high capability of resistance to light interference as well as improved resolution. The feasibility of multi-beam synchronous measurement based on PSD phase detection using FDM was validated by multi-beam measuring experiments. The maximum non-linearity error of the multi-beam synchronous measurement is 6.62%.

Adding rectifying/stripping section type heat integration to a pressure-swing distillation (PSD) process

International Nuclear Information System (INIS)

Huang Kejin; Shan Lan; Zhu Qunxiong; Qian Jixin

2008-01-01

This paper studies the economical effect of considering rectifying/stripping section type heat integration in a pressure-swing distillation (PSD) process separating a binary homogeneous pressure-sensitive azeotrope. The schemes for arranging heat integration between the rectifying section and the stripping section of the high- and low-pressure distillation columns, respectively, are derived and an effective procedure is devised for the conceptual process design of the heat-integrated PSD processes. In terms of the separation of a binary azeotropic mixture of acetonitrile and water, intensive comparisons are made between the conventional and heat-integrated PSD processes. It is demonstrated that breaking a pressure-sensitive azeotropic mixture can be made more economical than the current practice with the conventional PSD process. For boosting further the thermodynamic efficiency of a PSD process, it is strongly suggested to consider simultaneously the condenser/reboiler type heat integration with the rectifying/stripping section type heat integration in process synthesis and design

Hadron calorimeter (PSD) with new photo-detectors (MPPC) in NA61 experiment at CERN

Science.gov (United States)

Golubeva, M.; Guber, F.; Ivashkin, A.; Izvestnyy, A.; Kurepin, A.; Morozov, S.; Petukhov, O.; Selyuzhenkov, I.; Svintsov, I.; Taranenko, A.

2017-01-01

The Projectile Spectator Detector (PSD) is a segmented hadron calorimeter used in NA61 experiment (CERN) to determine a collision centrality as well as an event plane orientation in nucleus-nucleus collisions. The main goal of the experiment includes studying the onset of de-confinement and searching for the critical point of strongly interacting matter. It is of crucial importance to have a precise characterization of the event class with the PSD for the analysis of event-by-event observables. The PSD has been already used for centrality selection on trigger level in measurements of Be+Be and Ar+Sc reactions at beam energies 13 - 158 AGeV and Pb+Pb reaction at beam energy 30 AGeV. In 2016, the central modules of PSD have been equipped with new Hamamatsu MPPC silicon photo-detectors in order to extend dynamic range for studying Pb+Pb reaction at the full energy range 13 - 158 AGeV. Results of the PSD response on proton and lead beams are presented.

Adding rectifying/stripping section type heat integration to a pressure-swing distillation (PSD) process

Energy Technology Data Exchange (ETDEWEB)

Huang Kejin [School of Information Science and Technology, Beijing University of Chemical Technology, Chaoyang-qu, Beijing-shi, Beijing 100029 (China)], E-mail: huangkj@mail.buct.edu.cn; Shan Lan; Zhu Qunxiong [School of Information Science and Technology, Beijing University of Chemical Technology, Chaoyang-qu, Beijing-shi, Beijing 100029 (China); Qian Jixin [School of Information Science and Technology, Zhejiang University, Xihu-qu, Hangzhou-shi, Zhejiang 300027 (China)

2008-06-15

This paper studies the economical effect of considering rectifying/stripping section type heat integration in a pressure-swing distillation (PSD) process separating a binary homogeneous pressure-sensitive azeotrope. The schemes for arranging heat integration between the rectifying section and the stripping section of the high- and low-pressure distillation columns, respectively, are derived and an effective procedure is devised for the conceptual process design of the heat-integrated PSD processes. In terms of the separation of a binary azeotropic mixture of acetonitrile and water, intensive comparisons are made between the conventional and heat-integrated PSD processes. It is demonstrated that breaking a pressure-sensitive azeotropic mixture can be made more economical than the current practice with the conventional PSD process. For boosting further the thermodynamic efficiency of a PSD process, it is strongly suggested to consider simultaneously the condenser/reboiler type heat integration with the rectifying/stripping section type heat integration in process synthesis and design.

76 FR 7546 - Proposed Information Collection; Comment Request; Prohibited Species Donation (PSD) Program

Science.gov (United States)

2011-02-10

... Collection; Comment Request; Prohibited Species Donation (PSD) Program AGENCY: National Oceanic and... species donation (PSD) program for Pacific salmon and Pacific halibut has effectively reduced regulatory... individuals through tax-exempt organizations. Vessels and processing plants participating in the donation...

PSD Increment Consumption Guidance

Science.gov (United States)

This document may be of assistance in applying the New Source Review (NSR) air permitting regulations including the Prevention of Significant Deterioration (PSD) requirements. This document is part of the NSR Policy and Guidance Database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

PSD Increment Consumption Question

Science.gov (United States)

This document may be of assistance in applying the New Source Review (NSR) air permitting regulations including the Prevention of Significant Deterioration (PSD) requirements. This document is part of the NSR Policy and Guidance Database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Ocular Dominance Plasticity after Stroke Was Preserved in PSD-95 Knockout Mice.

Directory of Open Access Journals (Sweden)

Franziska Greifzu

Full Text Available Neuronal plasticity is essential to enable rehabilitation when the brain suffers from injury, such as following a stroke. One of the most established models to study cortical plasticity is ocular dominance (OD plasticity in the primary visual cortex (V1 of the mammalian brain induced by monocular deprivation (MD. We have previously shown that OD-plasticity in adult mouse V1 is absent after a photothrombotic (PT stroke lesion in the adjacent primary somatosensory cortex (S1. Exposing lesioned mice to conditions which reduce the inhibitory tone in V1, such as raising animals in an enriched environment or short-term dark exposure, preserved OD-plasticity after an S1-lesion. Here we tested whether modification of excitatory circuits can also be beneficial for preserving V1-plasticity after stroke. Mice lacking postsynaptic density protein-95 (PSD-95, a signaling scaffold present at mature excitatory synapses, have lifelong juvenile-like OD-plasticity caused by an increased number of AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid -silent synapses in V1 but unaltered inhibitory tone. In fact, using intrinsic signal optical imaging, we show here that OD-plasticity was preserved in V1 of adult PSD-95 KO mice after an S1-lesion but not in PSD-95 wildtype (WT-mice. In addition, experience-enabled enhancement of the optomotor reflex of the open eye after MD was compromised in both lesioned PSD-95 KO and PSD-95 WT mice. Basic V1-activation and retinotopic map quality were, however, not different between lesioned PSD-95 KO mice and their WT littermates. The preserved OD-plasticity in the PSD-95 KO mice indicates that V1-plasticity after a distant stroke can be promoted by either changes in excitatory circuitry or by lowering the inhibitory tone in V1 as previously shown. Furthermore, the present data indicate that an increased number of AMPA-silent synapses preserves OD-plasticity not only in the healthy brain, but also in another experimental

Puffy skin disease (PSD) in rainbow trout, Oncorhynchus mykiss (Walbaum): a case definition.

Science.gov (United States)

Maddocks, C E; Nolan, E T; Feist, S W; Crumlish, M; Richards, R H; Williams, C F

2015-07-01

Puffy skin disease (PSD) is a disease that causes skin pathology in rainbow trout, Oncorhynchus mykiss (Walbaum). Incidence of PSD in UK fish farms and fisheries has increased sharply in the last decade, with growing concern from both industry sectors. This paper provides the first comprehensive case definition of PSD, combining clinical and pathological observations of diseased rainbow trout from both fish farms and fisheries. The defining features of PSD, as summarized in the case definition, were focal lateral flank skin lesions that appeared as cutaneous swelling with pigment loss and petechiae. These were associated with lethargy, poor body condition, inappetance and low level mortality. Epidermal hyperplasia and spongiosis, oedema of the dermis stratum spongiosum and a mild diffuse inflammatory cellularity were typical in histopathology of skin. A specific pathogen or aetiology was not identified. Prevalence and severity of skin lesions was greatest during late summer and autumn, with the highest prevalence being 95%. Atypical lesions seen in winter and spring were suggestive of clinical resolution. PSD holds important implications for both trout aquaculture and still water trout fisheries. This case definition will aid future diagnosis, help avoid confusion with other skin conditions and promote prompt and consistent reporting. © 2014 John Wiley & Sons Ltd.

Application of PSD for low level alpha counting using liquid scintillation counting

International Nuclear Information System (INIS)

Krishnamachari, G.; Vaze, P.K.; Iyer, M.R.

1989-01-01

In the liquid scintillator the light produced by alpha particles decays differently than those produced by electrons. Pulse shape discrimination (PSD) methods are employed to estimate low levels of alpha emitting radionuclides by reducing the background due to either beta or gamma events. An attempt is being made to develop a liquid scintillation counting sytem using a simple PSD circuit to achieve a background of 0.01 counts/min. The PSD circuit is based on measuring zero cross over points to differentiate particle types. The input signal is first differentiated by a delay line and subsequently by a RC circuit. The width of the initial part of the doubly differentiated pulse is different for alpha and beta pulses. This width is converted to amplitude by a time-to-amplitude converter (TAC). The higher amplitude pulses from the TAC are due to alpha particles and they are separated by an integral discriminator. The output from the integral discriminator opens a linear gate to record the pulse height spectrum. The figure of merit of the PSD circuit and background in the alpha energy channel have been worked out using different scintillator types. (author). 4 figs

Thermodynamics of TMPC/PSd/Fullerene Nanocomposites: SANS Study

KAUST Repository

Chua, Yang-Choo; Chan, Alice; Wong, Him-Cheng; Higgins, Julia S.; Cabral, João T.

2010-01-01

) analysis demonstrate that 1-2 mass % of C60 fullerenes destabilizes a highly interacting mixture of poly(tetramethyl bisphenol A polycarbonate) and deuterated polystyrene (TMPC/PSd). We unequivocally corroborate these findings with time-resolved temperature

Transcriptional response to deletion of the phosphatidylserine decarboxylase Psd1p in the yeast Saccharomyces cerevisiae.

Science.gov (United States)

Gsell, Martina; Mascher, Gerald; Schuiki, Irmgard; Ploier, Birgit; Hrastnik, Claudia; Daum, Günther

2013-01-01

In the yeast, Saccharomyces cerevisiae, the synthesis of the essential phospholipid phosphatidylethanolamine (PE) is accomplished by a network of reactions which comprises four different pathways. The enzyme contributing most to PE formation is the mitochondrial phosphatidylserine decarboxylase 1 (Psd1p) which catalyzes conversion of phosphatidylserine (PS) to PE. To study the genome wide effect of an unbalanced cellular and mitochondrial PE level and in particular the contribution of Psd1p to this depletion we performed a DNA microarray analysis with a ∆psd1 deletion mutant. This approach revealed that 54 yeast genes were significantly up-regulated in the absence of PSD1 compared to wild type. Surprisingly, marked down-regulation of genes was not observed. A number of different cellular processes in different subcellular compartments were affected in a ∆psd1 mutant. Deletion mutants bearing defects in all 54 candidate genes, respectively, were analyzed for their growth phenotype and their phospholipid profile. Only three mutants, namely ∆gpm2, ∆gph1 and ∆rsb1, were affected in one of these parameters. The possible link of these mutations to PE deficiency and PSD1 deletion is discussed.

A comparison of different discrimination parameters for the DFT-based PSD method in fast scintillators

International Nuclear Information System (INIS)

Liu, G.; Yang, J.; Luo, X.L.; Lin, C.B.; Peng, J.X.; Yang, Y.

2013-01-01

Although the discrete Fourier transform (DFT) based pulse shape discrimination (PSD) method, realized by transforming the digitized scintillation pulses into frequency coefficients by using DFT, has been proven to effectively discriminate neutrons and γ rays, its discrimination performance depends strongly on the selection of the discrimination parameter obtained by the combination of these frequency coefficients. In order to thoroughly understand and apply the DFT-based PSD in organic scintillation detectors, a comparison of three different discrimination parameters, i.e. the amplitude of zero-frequency component, the amplitude difference between the amplitude of zero-frequency component and the amplitude of base-frequency component, and the ratio of the amplitude of base-frequency component to the amplitude of zero-frequency component, is described in this paper. An experimental setup consisting of an Americium–Beryllium (Am–Be) source, a BC501A liquid scintillator detector, and a 5Gsample/s 8-bit oscilloscope was built to assess the performance of the DFT-based PSD with each of these discrimination parameters in terms of the figure-of-merit (based on the separation of the event distributions). The third technique, which uses the ratio of the amplitude of base-frequency component to the amplitude of zero-frequency component as the discrimination parameter, is observed to provide the best discrimination performance in this research. - Highlights: • The spectrum difference between neutron pulse and γ-ray pulse was investigated. • The DFT-based PSD with different parameter definitions was assessed. • The way of using the ratio of magnitude spectrum provides the best performance. • The performance differences were explained from noise suppression features

Ocean thermal energy conversion power system development. Final design report: PSD-I, Phase II

Energy Technology Data Exchange (ETDEWEB)

None

1980-06-30

The PSD-I program provides a heat exchanger sytem consisting of an evaporator, condenser and various ancillaries with ammonia used as a working fluid in a closed simulated Rankine cycle. It is to be installed on the Chepachet Research Vessel for test and evaluation of a number of OTEC concepts in a true ocean environment. It is one of several test articles to be tested. Primary design concerns include control of biofouling, corrosion and erosion of aluminum tubes, selection of materials, and the development of a basis for scale-up to large heat exchangers so as to ultimately demonstrate economic feasibility on a commercial scale. The PSD-I test article is devised to verify thermodynamic, environmental, and mechanical performance of basic design concepts. The detailed design, development, fabrication, checklist, delivery, installation support, and operation support for the Test Article Heat Exchangers are described. (WHK)

Novel Method of Detecting Movement of the Interference Fringes Using One-Dimensional PSD

Directory of Open Access Journals (Sweden)

Qi Wang

2015-06-01

Full Text Available In this paper, a method of using a one-dimensional position-sensitive detector (PSD by replacing charge-coupled device (CCD to measure the movement of the interference fringes is presented first, and its feasibility is demonstrated through an experimental setup based on the principle of centroid detection. Firstly, the centroid position of the interference fringes in a fiber Mach-Zehnder (M-Z interferometer is solved in theory, showing it has a higher resolution and sensitivity. According to the physical characteristics and principles of PSD, a simulation of the interference fringe’s phase difference in fiber M-Z interferometers and PSD output is carried out. Comparing the simulation results with the relationship between phase differences and centroid positions in fiber M-Z interferometers, the conclusion that the output of interference fringes by PSD is still the centroid position is obtained. Based on massive measurements, the best resolution of the system is achieved with 5.15, 625 μm. Finally, the detection system is evaluated through setup error analysis and an ultra-narrow-band filter structure. The filter structure is configured with a one-dimensional photonic crystal containing positive and negative refraction material, which can eliminate background light in the PSD detection experiment. This detection system has a simple structure, good stability, high precision and easily performs remote measurements, which makes it potentially useful in material small deformation tests, refractivity measurements of optical media and optical wave front detection.

Mathematical Model and Calibration Procedure of a PSD Sensor Used in Local Positioning Systems.

Science.gov (United States)

Rodríguez-Navarro, David; Lázaro-Galilea, José Luis; Bravo-Muñoz, Ignacio; Gardel-Vicente, Alfredo; Domingo-Perez, Francisco; Tsirigotis, Georgios

2016-09-15

Here, we propose a mathematical model and a calibration procedure for a PSD (position sensitive device) sensor equipped with an optical system, to enable accurate measurement of the angle of arrival of one or more beams of light emitted by infrared (IR) transmitters located at distances of between 4 and 6 m. To achieve this objective, it was necessary to characterize the intrinsic parameters that model the system and obtain their values. This first approach was based on a pin-hole model, to which system nonlinearities were added, and this was used to model the points obtained with the nA currents provided by the PSD. In addition, we analyzed the main sources of error, including PSD sensor signal noise, gain factor imbalances and PSD sensor distortion. The results indicated that the proposed model and method provided satisfactory calibration and yielded precise parameter values, enabling accurate measurement of the angle of arrival with a low degree of error, as evidenced by the experimental results.

The Spotlight activity: Development and feasibility test of a naturalistic attention-redirection well-being intervention

Directory of Open Access Journals (Sweden)

Lilian Shin

2018-03-01

Full Text Available Positive activities, such as savoring, gratitude, and optimism, have been shown to boost positive emotions and reduce negative emotions. We argue that a shared mechanism driving their well-being benefits is the redirection of attention. In this feasibility study, we develop and pilot-test this mechanism with a novel positive activity intervention, the “spotlight activity,” that taught participants how to become mindful of where their attention was and to redirect it as needed. Individuals (initial N = 108 were randomly assigned to a 5-week spotlight activity intervention or to a waitlist control group and were assessed on measures of psychological well-being, need satisfaction, and hassles and uplifts. Preliminary results showed that, at post-test, the spotlight group reported significantly higher life satisfaction, meaning in life, and general weekly affect, as well as significantly lower negative affect and hassle intensity. The study provided initial evidence for the feasibility of a novel attention-redirection intervention and its potential to increase psychological well-being.

Interaction partners of PSD-93 studied by X-ray crystallography and fluorescence polarization spectroscopy

DEFF Research Database (Denmark)

Fiorentini, Monica; Bach, Anders; Strømgaard, Kristian

2013-01-01

PSD-93 (chapsyn-110, DLG2) is a member of the family of membrane-associated guanylate kinase (MAGUK) proteins. The MAGUK proteins are involved in receptor localization and signalling pathways. The best characterized MAGUK protein, PSD-95, is known to be involved in NMDA receptor signalling via it...

PSD Determination, Portland Cement Plant

Science.gov (United States)

This document may be of assistance in applying the New Source Review (NSR) air permitting regulations including the Prevention of Significant Deterioration (PSD) requirements. This document is part of the NSR Policy and Guidance Database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

United Salt Northeast PSD Determination

Science.gov (United States)

This document may be of assistance in applying the New Source Review (NSR) air permitting regulations including the Prevention of Significant Deterioration (PSD) requirements. This document is part of the NSR Policy and Guidance Database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

IB-11PSEUDO-PROGRESSION (PsdPg) IS A HARBINGER OF A MORE EFFECTIVE ANTI-TUMOR RESPONSE

Science.gov (United States)

Sturla, Lisa; Donahue, John; Machan, Jason; Delamonte, Suzanne; Jeyapalan, Suriya

2014-01-01

BACKGROUND: PsdPg is the increased contrast enhancement, high choline/creatine ratio and increased perfusion observed in the residual tumor bed of high-grade glioma patients after completion of temozolomide/radiation. It resolves within 3-6 months and incidence ranges from 10 - 31%. Though correlated with longer patient survival, its pathological basis is unclear. We used a cytokine/chemokine focused approach to compare the tumor microenvironment in pre- and post-treatment tumor tissue from patients with PsdPg to patients with true progression (TP). METHODS: We obtained pre-treatment formalin fixed paraffin embedded (FFPE) tissue from 35 GBM patients and post-treatment FFPE tissue from five patients with PsdPg and TP. A quantitative PCR array and custom Quantigene 2.0 multiplex was used to quantify gene expression corresponding to major cytokines/chemokines. An 18-gene signature was used to determine the macrophage polarization score (cumulative M2-associated cytokine expression - cumulative M1-associated cytokine expression). Immunohistochemistry (IHC) was used to confirm significantly different targets at the protein level. RESULTS: IHC revealed 7-fold higher B-cell infiltration in TP patients as compared to patients with PsdPg (p = 0.003). Macrophage and T-cell infiltration were not significantly different between the two groups. Nevertheless, the cytokines associated with macrophage polarization indicated pro-tumorigenic (M2) polarization in TP patients while PsdPg patients exhibited classical anti-tumorigenic (M1) polarization. TP patients had a 10-fold higher M2 score (p = 0.03) compared to PsdPg patients. The M1 score of tissue from PsdPg patients post-treatment was 25-fold higher than their pre-treatment tissue (p = 0.01). Analysis of a 7-gene signature associated with natural killer (NK) cell recruitment and activation showed a 8-fold higher expression in pre-treatment tissue from PsdPg patients compared to TP patients (p = 0.009) suggesting that NK cells

Arc Requires PSD95 for Assembly into Postsynaptic Complexes Involved with Neural Dysfunction and Intelligence

Directory of Open Access Journals (Sweden)

Esperanza Fernández

2017-10-01

Full Text Available Arc is an activity-regulated neuronal protein, but little is known about its interactions, assembly into multiprotein complexes, and role in human disease and cognition. We applied an integrated proteomic and genetic strategy by targeting a tandem affinity purification (TAP tag and Venus fluorescent protein into the endogenous Arc gene in mice. This allowed biochemical and proteomic characterization of native complexes in wild-type and knockout mice. We identified many Arc-interacting proteins, of which PSD95 was the most abundant. PSD95 was essential for Arc assembly into 1.5-MDa complexes and activity-dependent recruitment to excitatory synapses. Integrating human genetic data with proteomic data showed that Arc-PSD95 complexes are enriched in schizophrenia, intellectual disability, autism, and epilepsy mutations and normal variants in intelligence. We propose that Arc-PSD95 postsynaptic complexes potentially affect human cognitive function.

Data acquisition and processing software for linear PSD based neutron diffractometers

International Nuclear Information System (INIS)

Pande, S.S.; Borkar, S.P.; Ghodgaonkar, M.D.

2003-01-01

As a part of data acquisition system for various single and multi-PSD diffractometers software is developed to acquire the data and support the requirements of diffraction experiments. The software is a front-end Windows 98 application on PC and a transputer program on the MPSD card. The front-end application provides entire user interface required for data acquisition, control, presentation and system setup. Data is acquired and the diffraction spectra are generated in the transputer program. All the required hardware control is also implemented in the transputer program. The two programs communicate using a device driver named VTRANSPD. The software plays a vital role in customizing and integrating the data acquisition system for various diffractometer setups. Also the experiments are effectively automated in the software which has helped in making best use of available beam time. These and other features of the data acquisition and processing software are presented here. This software is being used along with the data acquisition system at a few single PSD and multi-PSD diffractometers. (author)

Neutron beam applications; development of texture measuring technique using 1-dimensional PSD

Energy Technology Data Exchange (ETDEWEB)

Park, No Jin; Lee, Moon Kyu; Joung, Tae Won; Lee, In Sung [Kumoh National University of Technology, Kumi (Korea)

2002-03-01

The new developed materials have often a low crystal symmetry or/and multi-phase state. Because the diffraction patterns of those materials are very complex and some peaks are overlapped, the measured pole figures with a conventional detector (0-dimensional detector) are not sufficient to use for the texture analysis. And also the widely broaden diffraction patterns caused by sever deformation, can only measured with lots of measuring errors using 0-dimensional detector. In this study the 1-dimensional and 2-dimensional position sensitive detector(PSD) is used such pattern to analyse. With PSD the more accurate pole figures can be measured, and the texture analysis, the estimation of the properties are determined more precisely. The measurement using PSD needs special technique for the analysis of the measured pattern. In this study the measuring and analysing technique is developed and compared with the conventional detector. 11 refs., 92 figs., 21 tabs. (Author)

Maximum likelihood PSD estimation for speech enhancement in reverberant and noisy conditions

DEFF Research Database (Denmark)

Kuklasinski, Adam; Doclo, Simon; Jensen, Jesper

2016-01-01

of the estimator is in speech enhancement algorithms, such as the Multi-channel Wiener Filter (MWF) and the Minimum Variance Distortionless Response (MVDR) beamformer. We evaluate these two algorithms in a speech dereverberation task and compare the performance obtained using the proposed and a competing PSD...... estimator. Instrumental performance measures indicate an advantage of the proposed estimator over the competing one. In a speech intelligibility test all algorithms significantly improved the word intelligibility score. While the results suggest a minor advantage of using the proposed PSD estimator...

Palmitoylation-dependent CDKL5-PSD-95 interaction regulates synaptic targeting of CDKL5 and dendritic spine development.

Science.gov (United States)

Zhu, Yong-Chuan; Li, Dan; Wang, Lu; Lu, Bin; Zheng, Jing; Zhao, Shi-Lin; Zeng, Rong; Xiong, Zhi-Qi

2013-05-28

The X-linked gene cyclin-dependent kinase-like 5 (CDKL5) is mutated in severe neurodevelopmental disorders, including some forms of atypical Rett syndrome, but the function and regulation of CDKL5 protein in neurons remain to be elucidated. Here, we show that CDKL5 binds to the scaffolding protein postsynaptic density (PSD)-95, and that this binding promotes the targeting of CDKL5 to excitatory synapses. Interestingly, this binding is not constitutive, but governed by palmitate cycling on PSD-95. Furthermore, pathogenic mutations that truncate the C-terminal tail of CDKL5 diminish its binding to PSD-95 and synaptic accumulation. Importantly, down-regulation of CDKL5 by RNA interference (RNAi) or interference with the CDKL5-PSD-95 interaction inhibits dendritic spine formation and growth. These results demonstrate a critical role of the palmitoylation-dependent CDKL5-PSD-95 interaction in localizing CDKL5 to synapses for normal spine development and suggest that disruption of this interaction by pathogenic mutations may be implicated in the pathogenesis of CDKL5-related disorders.

Spotlighting quantum critical points via quantum correlations at finite temperatures

International Nuclear Information System (INIS)

Werlang, T.; Ribeiro, G. A. P.; Rigolin, Gustavo

2011-01-01

We extend the program initiated by T. Werlang et al. [Phys. Rev. Lett. 105, 095702 (2010)] in several directions. Firstly, we investigate how useful quantum correlations, such as entanglement and quantum discord, are in the detection of critical points of quantum phase transitions when the system is at finite temperatures. For that purpose we study several thermalized spin models in the thermodynamic limit, namely, the XXZ model, the XY model, and the Ising model, all of which with an external magnetic field. We compare the ability of quantum discord, entanglement, and some thermodynamic quantities to spotlight the quantum critical points for several different temperatures. Secondly, for some models we go beyond nearest neighbors and also study the behavior of entanglement and quantum discord for second nearest neighbors around the critical point at finite temperature. Finally, we furnish a more quantitative description of how good all these quantities are in spotlighting critical points of quantum phase transitions at finite T, bridging the gap between experimental data and those theoretical descriptions solely based on the unattainable absolute zero assumption.

5-1 Beam Test of the PSD EQM at CERN

Institute of Scientific and Technical Information of China (English)

Zhou; Yong[1; Sun; Zhiyu[1; Yu; Yuhong[1; Fang; Fang[1; Zhang; Yongjie[1

2014-01-01

Dark Matter Particle Explorer (DAMPE) is a powerful space telescope for high energy cosmic rays detectionsuch as -ray, electron and heavy ions. The main motivation of DAMPE is to find the evidence of dark matterexistence, and the satellite is scheduled for launching before the end of 2015.The Plastic Scintillator Detector (PSD), which is oneof the key components of the DAMPE system, has twomajor functionalities: distinguish photons from chargedparticles by anti-coincidence and measure the charge ofheavy ions. The PSD is designed and fabricated by theinstitute of modern physics, CAS. It consists of 82 plasticscintillator strips, each of which is readout by PMTat both ends, and a double-dynode readout scheme forPMT is utilized in order to cover the large dynamicrange (from H to Ca).

PSD - Routine Maintenance Repair and Replacement

Science.gov (United States)

This document may be of assistance in applying the New Source Review (NSR) air permitting regulations including the Prevention of Significant Deterioration (PSD) requirements. This document is part of the NSR Policy and Guidance Database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Baseline Value for PSD Increment Consumption

Science.gov (United States)

This document may be of assistance in applying the New Source Review (NSR) air permitting regulations including the Prevention of Significant Deterioration (PSD) requirements. This document is part of the NSR Policy and Guidance Database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Palmitoylation-dependent CDKL5–PSD-95 interaction regulates synaptic targeting of CDKL5 and dendritic spine development

Science.gov (United States)

Zhu, Yong-Chuan; Li, Dan; Wang, Lu; Lu, Bin; Zheng, Jing; Zhao, Shi-Lin; Zeng, Rong; Xiong, Zhi-Qi

2013-01-01

The X-linked gene cyclin-dependent kinase-like 5 (CDKL5) is mutated in severe neurodevelopmental disorders, including some forms of atypical Rett syndrome, but the function and regulation of CDKL5 protein in neurons remain to be elucidated. Here, we show that CDKL5 binds to the scaffolding protein postsynaptic density (PSD)-95, and that this binding promotes the targeting of CDKL5 to excitatory synapses. Interestingly, this binding is not constitutive, but governed by palmitate cycling on PSD-95. Furthermore, pathogenic mutations that truncate the C-terminal tail of CDKL5 diminish its binding to PSD-95 and synaptic accumulation. Importantly, down-regulation of CDKL5 by RNA interference (RNAi) or interference with the CDKL5–PSD-95 interaction inhibits dendritic spine formation and growth. These results demonstrate a critical role of the palmitoylation-dependent CDKL5–PSD-95 interaction in localizing CDKL5 to synapses for normal spine development and suggest that disruption of this interaction by pathogenic mutations may be implicated in the pathogenesis of CDKL5-related disorders. PMID:23671101

PSD-95 is post-transcriptionally repressed during early neural development by PTBP1 and PTBP2

DEFF Research Database (Denmark)

Zheng, Sika; Gray, Erin E; Chawla, Geetanjali

2012-01-01

. The loss of first PTBP1 and then of PTBP2 during embryonic development allowed splicing of exon 18 and expression of PSD-95 late in neuronal maturation. Re-expression of PTBP1 or PTBP2 in differentiated neurons inhibited PSD-95 expression and impaired the development of glutamatergic synapses. Thus...

Site-Specific Phosphorylation of PSD-95 PDZ Domains Reveals Fine-Tuned Regulation of Protein-Protein Interactions

DEFF Research Database (Denmark)

Pedersen, Søren W; Albertsen, Louise; Moran, Griffin E

2017-01-01

The postsynaptic density protein of 95 kDa (PSD-95) is a key scaffolding protein that controls signaling at synapses in the brain through interactions of its PDZ domains with the C-termini of receptors, ion channels, and enzymes. PSD-95 is highly regulated by phosphorylation. To explore the effec...

Large eddy simulation of cooling flows in underground subway station according to different PSD operating conditions

Energy Technology Data Exchange (ETDEWEB)

Jang, Yong Jun; Kim, Jin Ho; Park, Sung Huk; Koo, Dong Hoe [Korea Railroad Research Institute, Uiwang (Korea, Republic of)

2015-11-15

Large eddy simulation (LES) method is applied to systematically investigate the cooling fluid flow and the temperature distribution under the operating of air conditioning in the deeply underground subway station. The Shin-Gum-Ho subway station in Seoul which is the 8{sup th} floor and 43.6 m deep is selected for this analysis. The entire station is covered for simulation. The ventilation mode for air conditioning is kept as ordinary state. Different operating conditions for Platform screen door (PSD) are applied. First one is PSD is completely close and second one is PSD is regularly open and close which imitate the actual circumstances in the platform. The ventilation diffusers are modeled as 95 square shapes in the lobby and 222 squares in the platform. The temperature variations and flow behaviors are numerically simulated after operating of air conditioning for the whole station and the calculated results are compared with experimental data. LES method solves the momentum and thermal equations. Werner-Wengle wall law is applied to viscous sub layers for near wall resolution. The total grid numbers are 7.5 million and the whole domain is divided to 22 blocks. Multi blocks are computed in parallel using MPI. The results show the temperature difference in the platform between PSD-close and PSD-regularly open and close cases is 3-4 .deg. C.

Large eddy simulation of cooling flows in underground subway station according to different PSD operating conditions

International Nuclear Information System (INIS)

Jang, Yong Jun; Kim, Jin Ho; Park, Sung Huk; Koo, Dong Hoe

2015-01-01

Large eddy simulation (LES) method is applied to systematically investigate the cooling fluid flow and the temperature distribution under the operating of air conditioning in the deeply underground subway station. The Shin-Gum-Ho subway station in Seoul which is the 8"t"h floor and 43.6 m deep is selected for this analysis. The entire station is covered for simulation. The ventilation mode for air conditioning is kept as ordinary state. Different operating conditions for Platform screen door (PSD) are applied. First one is PSD is completely close and second one is PSD is regularly open and close which imitate the actual circumstances in the platform. The ventilation diffusers are modeled as 95 square shapes in the lobby and 222 squares in the platform. The temperature variations and flow behaviors are numerically simulated after operating of air conditioning for the whole station and the calculated results are compared with experimental data. LES method solves the momentum and thermal equations. Werner-Wengle wall law is applied to viscous sub layers for near wall resolution. The total grid numbers are 7.5 million and the whole domain is divided to 22 blocks. Multi blocks are computed in parallel using MPI. The results show the temperature difference in the platform between PSD-close and PSD-regularly open and close cases is 3-4 .deg. C

Effects of dimeric PSD-95 inhibition on excitotoxic cell death and outcome after controlled cortical impact in rats

DEFF Research Database (Denmark)

Sommer, Jens Bak; Bach, Anders; Rytter, Hana Malá

2017-01-01

Therapeutic effects of PSD-95 inhibition have been demonstrated in numerous studies of stroke; however only few studies have assessed the effects of PSD-95 inhibitors in traumatic brain injury (TBI). As the pathophysiology of TBI partially overlaps with that of stroke, PSD-95 inhibition may also...... assessed in a water maze at two weeks post-trauma, and at four weeks lesion volumes were estimated. Overall, UCCB01-144 did not protect against NMDA-toxicity in neuronal cultures or experimental TBI in rats. Important factors that should be investigated further in future studies assessing the effects...... be an effective therapeutic strategy in TBI. The objectives of the present study were to assess the effects of a dimeric inhibitor of PSD-95, UCCB01-144, on excitotoxic cell death in vitro and outcome after experimental TBI in rats in vivo. In addition, the pharmacokinetic parameters of UCCB01-144 were...

A preliminary examination of the validity and reliability of a new brief rating scale for symptom domains of psychosis: Brief Evaluation of Psychosis Symptom Domains (BE-PSD).

Science.gov (United States)

Takeuchi, Hiroyoshi; Fervaha, Gagan; Lee, Jimmy; Agid, Ofer; Remington, Gary

2016-09-01

Brief assessments have the potential to be widely adopted as outcome measures in research but also routine clinical practice. Existing brief rating scales that assess symptoms of schizophrenia or psychosis have a number of limitations including inability to capture five symptom domains of psychosis and a lack of clearly defined operational anchor points for scoring. We developed a new brief rating scale for five symptom domains of psychosis with clearly defined operational anchor points - the Brief Evaluation of Psychosis Symptom Domains (BE-PSD). To examine the psychometric properties of the BE-PSD, fifty patients with schizophrenia or schizoaffective disorder were included in this preliminary cross-sectional study. To test the convergent and discriminant validity of the BE-PSD, correlational analyses were employed using the consensus Positive and Negative Syndrome Scale (PANSS) five-factor model. To examine the inter-rater reliability of the BE-PSD, single measures intraclass correlation coefficients (ICCs) were calculated for 11 patients. The BE-PSD domain scores demonstrated high convergent validity with the corresponding PANSS factor score (rs = 0.81-0.93) as well as good discriminant validity, as evidenced by lower correlations with the other PANSS factors (rs = 0.23-0.62). The BE-PSD also demonstrated excellent inter-rater reliability for each of the domain scores and the total scores (ICC(2,1) = 0.79-0.96). The present preliminary study found the BE-PSD measure to be valid and reliable; however, further studies are needed to establish the psychometric properties of the BE-PSD because of the limitations such as the small sample size and lacking data on test-retest reliability or sensitivity to change. Copyright © 2016 Elsevier Ltd. All rights reserved.

Numerical simulation and analysis of fuzzy PID and PSD control methodologies as dynamic energy efficiency measures

International Nuclear Information System (INIS)

Ardehali, M.M.; Saboori, M.; Teshnelab, M.

2004-01-01

Energy efficiency enhancement is achieved by utilizing control algorithms that reduce overshoots and undershoots as well as unnecessary fluctuations in the amount of energy input to energy consuming systems during transient operation periods. It is hypothesized that application of control methodologies with characteristics that change with time and according to the system dynamics, identified as dynamic energy efficiency measures (DEEM), achieves the desired enhancement. The objective of this study is to simulate and analyze the effects of fuzzy logic based tuning of proportional integral derivative (F-PID) and proportional sum derivative (F-PSD) controllers for a heating and cooling energy system while accounting for the dynamics of the major system components. The procedure to achieve the objective includes utilization of fuzzy logic rules to determine the PID and PSD controllers gain coefficients so that the control laws for regulating the heat exchangers heating or cooling energy inputs are determined in each time step of the operation period. The performances of the F-PID and F-PSD controllers are measured by means of two cost functions that are based on quadratic forms of the energy input and deviation from a set point temperature. It is found that application of the F-PID control algorithm, as a DEEM, results in lower costs for energy input and deviation from a set point temperature by 24% and 17% as compared to a PID and 13% and 8% as compared to a PSD, respectively. It is also shown that the F-PSD performance is better than that of the F-PID controller

PSD Permit for the Marblehead Lime Company

Science.gov (United States)

This document may be of assistance in applying the New Source Review (NSR) air permitting regulations including the Prevention of Significant Deterioration (PSD) requirements. This document is part of the NSR Policy and Guidance Database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Classification of Ethanol Fuel Plants under PSD

Science.gov (United States)

This document may be of assistance in applying the New Source Review (NSR) air permitting regulations including the Prevention of Significant Deterioration (PSD) requirements. This document is part of the NSR Policy and Guidance Database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Instrumentation for PSD based neutron diffractometers at Dhruva reactor

International Nuclear Information System (INIS)

Pande, S.S.; Borkar, S.P.; Prafulla, S.; Srivastava, V.D.; Behare, A.; Mukhopadhyay, P.K.; Ghodgaonkar, M.D.; Kataria, S.K.

2004-01-01

Linear position sensitive detectors (PSDs) are widely used to configure neutron diffractometers and other instruments. Necessary front-end electronics and a data acquisition system is developed to cater to such instruments built around the Dhruva research reactor in BARC. These include three diffractometers with multiple PSDs and four with single PSD. The front-end electronics consists of high voltage units, preamplifiers, shaping amplifiers, ratio ADCs (RDC). The data acquisition system consists of an interface card and software. Commercially available hardware like temperature controller or stepper motor controller connected over GPIB or RS232 are also integrated in the data acquisition system. The data acquisition is automated so that it can continue unattended for control parameter like temperature, thus enabling optimum utilization of available beam time. The instrumentation is scalable and can be easily configured for various instrumental requirements. The front-end electronics and the data acquisition system are described here. (author)

Space-Variant Post-Filtering for Wavefront Curvature Correction in Polar-Formatted Spotlight-Mode SAR Imagery

Energy Technology Data Exchange (ETDEWEB)

DOREN,NEALL E.

1999-10-01

with SVPF. This research concludes that PFA in conjunction with SVPF provides a computationally efficient spotlight-mode image formation solution that solves the wavefront curvature problem for most standoff distances and patch sizes, regardless of squint, resolution or radar center frequency. Additional advantages are that SVPF is not iterative and has no dependence on the visual contents of the scene: resulting in a deterministic computational complexity which typically adds only thirty percent to the overall image formation time.

Multi-channel PSD Estimators for Speech Dereverberation

DEFF Research Database (Denmark)

Kuklasinski, Adam; Doclo, Simon; Gerkmann, Timo

2015-01-01

densities (PSDs). We first derive closed-form expressions for the mean square error (MSE) of both PSD estimators and then show that one estimator – previously used for speech dereverberation by the authors – always yields a better MSE. Only in the case of a two microphone array or for special spatial...... distributions of the interference both estimators yield the same MSE. The theoretically derived MSE values are in good agreement with numerical simulation results and with instrumental speech quality measures in a realistic speech dereverberation task for binaural hearing aids....

Internal Exposure of a Seoul Subway Passenger due to Radon Inhalation: Before and After PSD Installation

Energy Technology Data Exchange (ETDEWEB)

Shin, Ji-Yong; Kim, Eun-Hee [Seoul National University, Seoul (Korea, Republic of)

2015-05-15

Radon is the major source of public exposure to natural radiation and is also known to cause lung cancer. Platform screen doors (PSD) were installed primarily for passenger's safety purposes. Radon concentration and aerosol distribution have been changed since PSD installation. In this study, we have assessed the annual effective dose of regular subway passengers, before and after PSD installation, by employing current available data on air concentration of radon in Seoul subways with aerosol size distributions taken into account. ICRP recommends that the reference value for internal dose from radon be between 1.0 and 20.0 mSv. Korean Ministry of Environment enacted the indoor radon regulation, which requires the indoor radon level should not exceed 148 Bq/m{sup 3}. Radon concentrations in Seoul subways and annual dose estimates meet the requirements.

Internal Exposure of a Seoul Subway Passenger due to Radon Inhalation: Before and After PSD Installation

International Nuclear Information System (INIS)

Shin, Ji-Yong; Kim, Eun-Hee

2015-01-01

Radon is the major source of public exposure to natural radiation and is also known to cause lung cancer. Platform screen doors (PSD) were installed primarily for passenger's safety purposes. Radon concentration and aerosol distribution have been changed since PSD installation. In this study, we have assessed the annual effective dose of regular subway passengers, before and after PSD installation, by employing current available data on air concentration of radon in Seoul subways with aerosol size distributions taken into account. ICRP recommends that the reference value for internal dose from radon be between 1.0 and 20.0 mSv. Korean Ministry of Environment enacted the indoor radon regulation, which requires the indoor radon level should not exceed 148 Bq/m 3 . Radon concentrations in Seoul subways and annual dose estimates meet the requirements

Tank Farm WM-182 and WM-183 Heel Slurry Samples PSD Results

International Nuclear Information System (INIS)

Batcheller, T.A.; Huestis, G.M.

2000-01-01

Particle size distribution (PSD) analysis of INTEC Tank Farm WM-182 and WM-183 heel slurry samples were performed using a modified Horiba LA-300 PSD analyzer at the RAL facility. There were two types of testing performed: typical PSD analysis, and setting rate testing. Although the heel slurry samples were obtained from two separate vessels, the particle size distribution results were quite similar. The slurry solids were from approximately a minimum particle size of 0.5 mm to a maximum of 230 mm with about 90% of the material between 2-to-133 mm, and the cumulative 50% value at approximately 20 mm. This testing also revealed that high frequency sonication with an ultrasonic element may break-up larger particles in the WM-182 and WM-183 tank from heel slurries. This finding represents useful information regarding ultimate tank heel waste processing. Settling rate testing results were also fairly consistent with material from both vessels in that it appears that most of the mass of solids settle to an agglomerated, yet easily redispersed layer at the bottom. A dispersed and suspended material remained in the ''clear'' layer above the settled layer after about one-half an hour of settling time. This material had a statistical mode of approximately 5 mm and a maximum particle size of 30 mm

Living in the spotlight

CERN Multimedia

2009-01-01

Just a few weeks ago, we celebrated the 20th anniversary of the World Wide Web. It gave me my first opportunity since taking up my mandate to see first hand what CERN’s newfound public profile means in practice. There were over 60 media from around the world present at CERN for the event, and some 900 reports in the media over the following days. Some weeks before, Sony pictures held a press event for their upcoming movie, Angels and Demons, part of which takes place at CERN. That happened during the same week that we published the new LHC schedule, and it was the LHC that got the most media coverage. So what does this mean for how we carry out our daily work? Particle physics has always operated in a fully open and transparent way. It’s in our DNA to do so. Meetings are open to all comers, and it is important that we continue to foster such a culture of transparency. Nevertheless, we need to be aware that we are much more in the public spotlight than ever before....

Importance of lunar and temporal conditions for spotlight surveys of adult black-footed ferrets

Science.gov (United States)

Eads, David A.; Jachowski, David S.; Millspaugh, Joshua J.; Biggins, Dean E.

2012-01-01

Black-footed ferrets (Mustela nigripes) spend most daylight hours underground in prairie dog (Cynomys) burrows and exhibit aboveground movements primarily at night. Moonlight can influence the activity patterns of ferrets and, consequently, might influence the efficiency of spotlight surveys used by biologists to monitor ferret populations. We related detection of adult ferrets during postbreeding spotlight surveys to lunar and temporal conditions. We most frequently located ferrets during surveys in which the moon breached the horizon. The data suggested intersexual differences in response to moonlight. We located male ferrets most frequently during nights with greater moon illumination, but we did not detect a correlation between moon illumination and spotlight detection of female ferrets. In general, moonlight could facilitate aboveground navigation by ferrets. However, it seems activity under bright moonlight could be costly for female ferrets while they raise young. Detection of ferrets also varied among months. We detected female ferrets most frequently in August–September, when mothers increase hunting efforts to acquire prey for growing offspring (kits). Detection of adult female ferrets declined in October, when kits were likely independent of their mother. We located male ferrets most frequently in September–October, when males might increase activity to monitor female ferrets and male competitors. Consideration of lunar and temporal influences and standardization of postbreeding surveys could enhance site-specific assessment of reintroduction success and across-site assessment of species recoveiy progress. We suggest that postbreeding surveys for ferrets should be enhanced by concentrating efforts in August–September during moonlit nights when the moon is above the horizon.

Freeform TIR collimators for the removal of angular color variation in white LED spotlights

NARCIS (Netherlands)

Prins, C.R.; Schneider, C.; IJzerman, W.L.; Tukker, T.W.; Thije Boonkkamp, ten J.H.M.; Winston, R.; Gordon, J.

2013-01-01

Angular color variation in white, phosphor-converted LEDs causes undesirable yellow rings in the beams of spotlights. We developed an inverse method to design TIR collimators that remove the angular color variation for point light sources and significantly reduce color variation for extended light

Instrumentation for PSD-based neutron diffractometers at Dhruva reactor

Science.gov (United States)

Pande, S. S.; Borkar, S. P.; Prafulla, S.; Srivastava, V. D.; Behare, A.; Mukhopadhyay, P. K.; Ghodgaonkar, M. D.; Kataria, S. K.

2004-08-01

Linear position sensitive detectors (PSDs) are widely used to configure neutron diffractometers and other instruments. Necessary front-end electronics and a data acquisition system [1] is developed to cater to such instruments built around the Dhruva research reactor in BARC. These include three diffractometers with multiple PSDs and four with single PSD. The front-end electronics consists of high voltage units, preamplifiers [2], shaping amplifiers, ratio ADCs (RDC) [3]. The data acquisition system consists of an interface card and software. Commercially available hardware like temperature controller or stepper motor controller connected over GPIB or RS232 are also integrated in the data acquisition system. The data acquisition is automated so that it can continue unattended for control parameter like temperature, thus enabling optimum utilization of available beam time. The instrumentation is scalable and can be easily configured for various instrumental requirements. The front-end electronics and the data acquisition system are described here.

DA Negatively Regulates IGF-I Actions Implicated in Cognitive Function via Interaction of PSD95 and nNOS in Minimal Hepatic Encephalopathy.

Science.gov (United States)

Ding, Saidan; Zhuge, Weishan; Wang, Xuebao; Yang, Jianjing; Lin, Yuanshao; Wang, Chengde; Hu, Jiangnan; Zhuge, Qichuan

2017-01-01

Insulin-like growth factor I (IGF-I) has been positively correlated with cognitive ability. Cognitive decline in minimal hepatic encephalopathy (MHE) was shown to be induced by elevated intracranial dopamine (DA). The beneficial effect of IGF-I signaling in MHE remains unknown. In this study, we found that IGF-I content was reduced in MHE rats and that IGF-I administration mitigated cognitive decline of MHE rats. A protective effect of IGF-I on the DA-induced interaction between postsynaptic density protein 95 (PSD95) and neuronal nitric oxide synthase (nNOS) was found in neurons. Ribosomal S6 protein kinase (RSK) phosphorylated nNOS in response to IGF-I by recruiting extracellular signal-regulated kinase (ERK1/2). In turn, DA inactivated the ERK1/2/RSK pathway and stimulated the PSD95-nNOS interaction by downregulating IGF-I. Inhibition of the interaction between PSD95 and nNOS ameliorated DA-induced memory impairment. As DA induced deficits in the ERK1/2/RSK pathway and the interaction between PSD95 and nNOS in MHE brains, IGF-I administration exerted a protective effect via interruption of the interaction between PSD95 and nNOS. These results suggest that IGF-I antagonizes DA-induced cognitive loss by disrupting PSD95-nNOS interactions in MHE.

DA Negatively Regulates IGF-I Actions Implicated in Cognitive Function via Interaction of PSD95 and nNOS in Minimal Hepatic Encephalopathy

Directory of Open Access Journals (Sweden)

Saidan Ding

2017-09-01

Full Text Available Insulin-like growth factor I (IGF-I has been positively correlated with cognitive ability. Cognitive decline in minimal hepatic encephalopathy (MHE was shown to be induced by elevated intracranial dopamine (DA. The beneficial effect of IGF-I signaling in MHE remains unknown. In this study, we found that IGF-I content was reduced in MHE rats and that IGF-I administration mitigated cognitive decline of MHE rats. A protective effect of IGF-I on the DA-induced interaction between postsynaptic density protein 95 (PSD95 and neuronal nitric oxide synthase (nNOS was found in neurons. Ribosomal S6 protein kinase (RSK phosphorylated nNOS in response to IGF-I by recruiting extracellular signal-regulated kinase (ERK1/2. In turn, DA inactivated the ERK1/2/RSK pathway and stimulated the PSD95–nNOS interaction by downregulating IGF-I. Inhibition of the interaction between PSD95 and nNOS ameliorated DA-induced memory impairment. As DA induced deficits in the ERK1/2/RSK pathway and the interaction between PSD95 and nNOS in MHE brains, IGF-I administration exerted a protective effect via interruption of the interaction between PSD95 and nNOS. These results suggest that IGF-I antagonizes DA-induced cognitive loss by disrupting PSD95–nNOS interactions in MHE.

Effect of complex aerobic physical exercise on PSD-95 in the hippocampus and on cognitive function in juvenile mice

Science.gov (United States)

Satriani, W. H.; Redjeki, S.; Kartinah, N. T.

2017-08-01

Increased neuroplasticity induced by complex aerobic physical exercise is associated with improved cognitive function in adult mice. Increased cognitive function is assumed to be based on increased synapse formation. One of the regions of the brain that is important in cognitive function is the hippocampus, which plays a role in memory formation. Post synaptic density-95 (PSD-95) is an adhesion protein of the post-synaptic density scaffolding that is essential to synaptic stabilization. As we age, the PSD-95 molecule matures the synapses needed for the formation of the basic circuitry of the nervous system in the brain. However, during the growth period, synapse elimination is higher than its formation. This study aims to determine whether complex aerobic exercise can improve cognitive function and PSD-95 levels in the hippocampus of juvenile mice during their growth stage. The mice performed complex aerobic exercise starting at five weeks of age and continuing for seven weeks with a gradual increase of 8 m/min. At eight weeks it was increased to 10 m/min. The exercise was done for five days of each week. The subjects of the study were tested for cognition one week before being sacrificed (at 12 weeks). The PSD-95 in the hippocampus was measured with ELISA. The results showed that there was a significant difference in cognitive function, where p cognitive ability in adulthood but does not increase the levels of PSD-95 in adults.

ASIC2 Subunits Target Acid-Sensing Ion Channels to the Synapse via an Association with PSD-95

OpenAIRE

Zha, Xiang-ming; Costa, Vivian; Harding, Anne Marie S.; Reznikov, Leah; Benson, Christopher J.; Welsh, Michael J.

2009-01-01

Acid-sensing ion channel-1a (ASIC1a) mediates H+-gated current to influence normal brain physiology and impact several models of disease. Although ASIC2 subunits are widely expressed in brain and modulate ASIC1a current, their function remains poorly understood. We identified ASIC2a in dendrites, dendritic spines, and brain synaptosomes. This localization largely relied on ASIC2a binding to PSD-95 and matched that of ASIC1a, which does not co-immunoprecipitate with PSD-95. We found that ASIC2...

PSD-95 uncoupling from NMDA receptors by Tat-N-dimer ameliorates neuronal depolarisation in cortical spreading depression

DEFF Research Database (Denmark)

Kucharz, Krzysztof; Søndergaard Rasmussen, Ida; Bach, Anders

2017-01-01

during the first hour after i.v. injection. The Tat-N-dimer suppressed stimulation-evoked synaptic activity by 2-20%, while cortical blood flow and cerebral oxygen metabolic (CMRO2) responses were preserved. During cortical spreading depression, the Tat-N-dimer reduced the average amplitude...... depression on cortical blood flow and CMRO2 We suggest that uncoupling of PSD-95 from NMDA receptors reduces overall neuronal excitability and the amplitude of the spreading depolarisation wave. These findings may be of interest for understanding the neuroprotective effects of the nNOS/PSD-95 uncoupling...

A Spotlight on Chemical Constituents and Pharmacological Activities of Nigella glandulifera Freyn et Sint Seeds

Directory of Open Access Journals (Sweden)

Besma Boubertakh

2013-01-01

Full Text Available Plants belonging to the Ranunculaceae family, and particularly their seeds, have been a hot research topic in numerous pharmacognosy laboratories. Nigella glandulifera Freyn et Sint (NG is one of the promising, but relatively insufficiently studied, plants from this family. In this review, we summarize the recently isolated chemical constituents from the seeds of this plant including alkaloids, flavonol glycosides, isobenzofuranone derivatives, saponins, terpenes, terpenoids, and fatty acids. We put also a spotlight on the recently studied therapeutic potentials of such amazing herb seeds as antidiabetes, melanogenesis inhibition, anticancer, anti-inflammatory, antithrombosis, and antiplatelet aggregation effects. Herein, we illustrate certain properties and potentials via selected examples, and thus we suggest more studies to confirm the therapeutic hypotheses, find out new compounds, and eventually to discover novel properties.

Hospitality and Inclusion Logistics of a Spotlight Event: An Insiders Look at the 2016 DNC in Philadelphia

Directory of Open Access Journals (Sweden)

Leora Halpern Lanz

2016-10-01

Full Text Available The 2016 Democratic National Convention held in Philadelphia, Pennsylvania prioritized hospitality efforts and incorporated inclusion and diversity as its theme. These strategies helped to create a successful spotlight event, benefiting the city of Philadelphia and its hospitality industry.

Palmitoylation-dependent CDKL5–PSD-95 interaction regulates synaptic targeting of CDKL5 and dendritic spine development

OpenAIRE

Zhu, Yong-Chuan; Li, Dan; Wang, Lu; Lu, Bin; Zheng, Jing; Zhao, Shi-Lin; Zeng, Rong; Xiong, Zhi-Qi

2013-01-01

The X-linked gene cyclin-dependent kinase-like 5 (CDKL5) is mutated in severe neurodevelopmental disorders, including some forms of atypical Rett syndrome, but the function and regulation of CDKL5 protein in neurons remain to be elucidated. Here, we show that CDKL5 binds to the scaffolding protein postsynaptic density (PSD)-95, and that this binding promotes the targeting of CDKL5 to excitatory synapses. Interestingly, this binding is not constitutive, but governed by palmitate cycling on PSD...

National Asphalt Pavement Association Questions and Answers on PSD

Science.gov (United States)

This document may be of assistance in applying the New Source Review (NSR) air permitting regulations including the Prevention of Significant Deterioration (PSD) requirements. This document is part of the NSR Policy and Guidance Database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Classification of the Bardstown Fuel Alcohol Company under PSD

Science.gov (United States)

This document may be of assistance in applying the New Source Review (NSR) air permitting regulations including the Prevention of Significant Deterioration (PSD) requirements. This document is part of the NSR Policy and Guidance Database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Current developments in environmental psychology : topics and researchers

NARCIS (Netherlands)

van der Werff, Ellen; Perlaviciute, Goda; Muinos, Gabriel

2016-01-01

The aim of this special issue is to bring the work of early-career researchers in environmental psychology to the spotlight. These young researchers come from different countries and cultures, have their own theoretical approaches and employ different research methods to increase knowledge on the

Particle-size distribution (PSD) of pulverized hair: A quantitative approach of milling efficiency and its correlation with drug extraction efficiency.

Science.gov (United States)

Chagas, Aline Garcia da Rosa; Spinelli, Eliani; Fiaux, Sorele Batista; Barreto, Adriana da Silva; Rodrigues, Silvana Vianna

2017-08-01

Different types of hair were submitted to different milling procedures and their resulting powders were analyzed by scanning electron microscopy (SEM) and laser diffraction (LD). SEM results were qualitative whereas LD results were quantitative and accurately characterized the hair powders through their particle size distribution (PSD). Different types of hair were submitted to an optimized milling conditions and their PSD was quite similar. A good correlation was obtained between PSD results and ketamine concentration in a hair sample analyzed by LC-MS/MS. Hair samples were frozen in liquid nitrogen for 5min and pulverized at 25Hz for 10min, resulting in 61% of particles sample extracted after pulverization comparing with the same sample cut in 1mm fragments. When milling time was extended to 25min, >90% of particles were sample retesting and quality control procedures. Copyright © 2017 Elsevier B.V. All rights reserved.

Role of Research and Development in the 21st Century

Directory of Open Access Journals (Sweden)

2007-01-01

Full Text Available For the countries the importance of Research and Development has increased lately. In order to strengthened the economy of that given country more input are needed towards to these direction. Those countries that support researches could achieve higher GDP, which is an important issue. So these questions stepped into spotlight to try to close up the gap between the different levels of development. In the fist part of the paper the current EU Regulation was in spotlight. An observation was made to point out the lower R&D role than desired by the EU itself. With calculations of the different origin of sources and their relationship with the GDP per person we would like to point out the importance of the research and investment level in the future growing.

USDA Forest Service, Rocky Mountain Region PSD Permit Completeness Determination

Science.gov (United States)

This document may be of assistance in applying the New Source Review (NSR) air permitting regulations including the Prevention of Significant Deterioration (PSD) requirements. This document is part of the NSR Policy and Guidance Database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Applicability of PSD to Pennsylvania Power and Light Auxiliary Boiler

Science.gov (United States)

This document may be of assistance in applying the New Source Review (NSR) air permitting regulations including the Prevention of Significant Deterioration (PSD) requirements. This document is part of the NSR Policy and Guidance Database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Request for Guidance on PSD Applicability Determinations for Boiler Emissions

Science.gov (United States)

This document may be of assistance in applying the New Source Review (NSR) air permitting regulations including the Prevention of Significant Deterioration (PSD) requirements. This document is part of the NSR Policy and Guidance Database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Alaska: Improving Referrals of Victims of Maltreatment to the IDEA Part C Program. State Spotlight: Data Sharing

Science.gov (United States)

Derrington, Taletha; Peters, Mary Louise; Mauzy, Denise; Ruggiero, Robert

2015-01-01

This 2015 state spotlight document describes how Alaska Part C improved the referral of children from Child Welfare to the Individuals with Disabilities Education Act (IDEA) Part C Program by an automated transfer of data from Child Welfare to Part C for substantiated cases of child maltreatment (i.e., child abuse and/or neglect).

Voicing Others' Voices: Spotlighting the Researcher as Narrator

Science.gov (United States)

O'Sullivan, Dan

2015-01-01

As qualitative research undertakings are not independent of the researcher, the "indissoluble interrelationship between interpreter and interpretation" (Thomas & James, 2006, p. 782) renders it necessary for researchers to understand that their text is a representation, a version of the truth that is the product of writerly choices,…

75 FR 27643 - Prevention of Significant Deterioration (PSD) and Nonattainment New Source Review (NSR): Aggregation

Science.gov (United States)

2010-05-18

... once the delay is no longer necessary. ADDRESSES: Docket: The final rule, the petition for...): Aggregation AGENCY: Environmental Protection Agency (EPA). ACTION: Delay of effective date. SUMMARY: EPA is delaying the effective date of the final rule titled ``Prevention of Significant Deterioration (PSD) and...

PSD Determination: Sun Oil Company and the Definition of Major Modification

Science.gov (United States)

This document may be of assistance in applying the New Source Review (NSR) air permitting regulations including the Prevention of Significant Deterioration (PSD) requirements. This document is part of the NSR Policy and Guidance Database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Interim Policy Determination Related to NSR/PSD Significance Level for ODS

Science.gov (United States)

This document may be of assistance in applying the New Source Review (NSR) air permitting regulations including the Prevention of Significant Deterioration (PSD) requirements. This document is part of the NSR Policy and Guidance Database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Sustainable prevention of obesity through integrated strategies: The SPOTLIGHT project’s conceptual framework and design

Directory of Open Access Journals (Sweden)

Lakerveld Jeroen

2012-09-01

Full Text Available Abstract Background The prevalence of overweight and obesity in Europe is high. It is a major cause of the overall rates of many of the main chronic (or non communicable diseases in this region and is characterized by an unequal socio-economic distribution within the population. Obesity is largely determined by modifiable lifestyle behaviours such as low physical activity levels, sedentary behaviour and consumption of energy dense diets. It is increasingly being recognised that effective responses must go beyond interventions that only focus on a specific individual, social or environmental level and instead embrace system-based multi-level intervention approaches that address both the individual and environment. The EU-funded project “sustainable prevention of obesity through integrated strategies” (SPOTLIGHT aims to increase and combine knowledge on the wide range of determinants of obesity in a systematic way, and to identify multi-level intervention approaches that are strong in terms of Reach, Efficacy, Adoption, Implementation and Maintenance (RE-AIM. Methods/Design SPOTLIGHT comprises a series of systematic reviews on: individual-level predictors of success in behaviour change obesity interventions; social and physical environmental determinants of obesity; and on the RE-AIM of multi-level interventions. An interactive web-atlas of currently running multi-level interventions will be developed, and enhancing and impeding factors for implementation will be described. At the neighbourhood level, these elements will inform the development of methods to assess obesogenicity of diverse environments, using remote imaging techniques linked to geographic information systems. The validity of these methods will be evaluated using data from surveys of health and lifestyles of adults residing in the neighbourhoods surveyed. At both the micro- and macro-levels (national and international the different physical, economical, political and socio

Making an Impact: New Directions for Arts and Humanities Research

Science.gov (United States)

Hazelkorn, Ellen

2015-01-01

The severity of the global economic crisis has put the spotlight firmly on measuring academic and research performance and productivity and assessing its contribution, value, impact and benefit. While, traditionally, research output and impact were measured by peer-publications and citations, there is increased emphasis on a "market-driven…

Frequently Asked Questions (Palliative Care: Conversations Matter)

Science.gov (United States)

... Medicine at NINR Research Highlights Data Science and Nursing Research Spotlight on End-of-Life and Palliative Care Research Spotlight on Symptom Management Research Spotlight on Pain Research The Science of Compassion: Future Directions in ...

Fuzzy norm method for evaluating random vibration of airborne platform from limited PSD data

Directory of Open Access Journals (Sweden)

Wang Zhongyu

2014-12-01

Full Text Available For random vibration of airborne platform, the accurate evaluation is a key indicator to ensure normal operation of airborne equipment in flight. However, only limited power spectral density (PSD data can be obtained at the stage of flight test. Thus, those conventional evaluation methods cannot be employed when the distribution characteristics and priori information are unknown. In this paper, the fuzzy norm method (FNM is proposed which combines the advantages of fuzzy theory and norm theory. The proposed method can deeply dig system information from limited data, which probability distribution is not taken into account. Firstly, the FNM is employed to evaluate variable interval and expanded uncertainty from limited PSD data, and the performance of FNM is demonstrated by confidence level, reliability and computing accuracy of expanded uncertainty. In addition, the optimal fuzzy parameters are discussed to meet the requirements of aviation standards and metrological practice. Finally, computer simulation is used to prove the adaptability of FNM. Compared with statistical methods, FNM has superiority for evaluating expanded uncertainty from limited data. The results show that the reliability of calculation and evaluation is superior to 95%.

An Update on the NASA Planetary Science Division Research and Analysis Program

Science.gov (United States)

Richey, Christina; Bernstein, Max; Rall, Jonathan

2015-01-01

Introduction: NASA's Planetary Science Division (PSD) solicits its Research and Analysis (R&A) programs each year in Research Opportunities in Space and Earth Sciences (ROSES). Beginning with the 2014 ROSES solicitation, PSD will be changing the structure of the program elements under which the majority of planetary science R&A is done. Major changes include the creation of five core research program elements aligned with PSD's strategic science questions, the introduction of several new R&A opportunities, new submission requirements, and a new timeline for proposal submissionROSES and NSPIRES: ROSES contains the research announcements for all of SMD. Submission of ROSES proposals is done electronically via NSPIRES: http://nspires.nasaprs.com. We will present further details on the proposal submission process to help guide younger scientists. Statistical trends, including the average award size within the PSD programs, selections rates, and lessons learned, will be presented. Information on new programs will also be presented, if available.Review Process and Volunteering: The SARA website (http://sara.nasa.gov) contains information on all ROSES solicitations. There is an email address (SARA@nasa.gov) for inquiries and an area for volunteer reviewers to sign up. The peer review process is based on Scientific/Technical Merit, Relevance, and Level of Effort, and will be detailed within this presentation.ROSES 2014 submission changes: All PSD programs will use a two-step proposal submission process. A Step-1 proposal is required and must be submitted electronically by the Step-1 due date. The Step-1 proposal should include a description of the science goals and objectives to be addressed by the proposal, a brief description of the methodology to be used to address the science goals and objectives, and the relevance of the proposed research to the call submitted to.Additional Information: Additional details will be provided on the Cassini Data Analysis Program, the

Part four: The research dissertation: planning, producing and writing a thesis.

Science.gov (United States)

Quick, J; Hall, S

2015-11-01

Dissertations have become common inclusions to postgraduate degrees in healthcare. To the novice researcher, undertaking an extensive project of this kind can appear daunting. In this final article in the series 'Spotlight on Research', Julie Quick and Susan Hall advise perioperative practitioners on how to plan, produce and write a research dissertation. Guidance is also given on disseminating the results from research studies.

Contingency Plan for FGD Systems During Downtime as a Function of PSD

Science.gov (United States)

This document may be of assistance in applying the New Source Review (NSR) air permitting regulations including the Prevention of Significant Deterioration (PSD) requirements. This document is part of the NSR Policy and Guidance Database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

PSD Applicability of SO2 Emissions from Incineration of Total Reduced Sulfur

Science.gov (United States)

This document may be of assistance in applying the New Source Review (NSR) air permitting regulations including the Prevention of Significant Deterioration (PSD) requirements. This document is part of the NSR Policy and Guidance Database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

PSD Applicability for Ashland Chemical's Maleic Anhydride Plant in Neal, West Virginia

Science.gov (United States)

This document may be of assistance in applying the New Source Review (NSR) air permitting regulations including the Prevention of Significant Deterioration (PSD) requirements. This document is part of the NSR Policy and Guidance Database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Tire Derived Fuel Classified as Municipal Solid Waste for a PSD Exemption

Science.gov (United States)

This document may be of assistance in applying the New Source Review (NSR) air permitting regulations including the Prevention of Significant Deterioration (PSD) requirements. This document is part of the NSR Policy and Guidance Database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Thermodynamics of TMPC/PSd/Fullerene Nanocomposites: SANS Study

KAUST Repository

Chua, Yang-Choo

2010-11-23

Wereport a small angle neutron scattering study of the thermodynamics of a polymer mixture in the presence of nanoparticles, both in equilibrium and during phase separation. Neutron cloud point measurements and random phase approximation (RPA) analysis demonstrate that 1-2 mass % of C60 fullerenes destabilizes a highly interacting mixture of poly(tetramethyl bisphenol A polycarbonate) and deuterated polystyrene (TMPC/PSd). We unequivocally corroborate these findings with time-resolved temperature jump experiments that, in identical conditions, result in phase separation for the nanocomposite and stability for the neat polymer mixture. At lower C 60 loadings (viz. 0.2-0.5 mass %), stabilization of the mixture is observed. The nonmonotonic variation of the spinodal temperature with fullerene addition suggests a competitive interplay of asymmetric component interactions and nanoparticle dispersion. The stability line shift depends critically on particle dispersion and vanishes upon nanoparticle agglomeration. © 2010 American Chemical Society.

Quantitative analysis and efficiency study of PSD methods for a LaBr{sub 3}:Ce detector

Energy Technology Data Exchange (ETDEWEB)

Zeng, Ming; Cang, Jirong [Key Laboratory of Particle & Radiation Imaging(Tsinghua University), Ministry of Education (China); Department of Engineering Physics, Tsinghua University, Beijing 100084 (China); Zeng, Zhi, E-mail: zengzhi@tsinghua.edu.cn [Key Laboratory of Particle & Radiation Imaging(Tsinghua University), Ministry of Education (China); Department of Engineering Physics, Tsinghua University, Beijing 100084 (China); Yue, Xiaoguang; Cheng, Jianping; Liu, Yinong; Ma, Hao; Li, Junli [Key Laboratory of Particle & Radiation Imaging(Tsinghua University), Ministry of Education (China); Department of Engineering Physics, Tsinghua University, Beijing 100084 (China)

2016-03-21

The LaBr{sub 3}:Ce scintillator has been widely studied for nuclear spectroscopy because of its optimal energy resolution (<3%@ 662 keV) and time resolution (~300 ps). Despite these promising properties, the intrinsic radiation background of LaBr{sub 3}:Ce is a critical issue, and pulse shape discrimination (PSD) has been shown to be an efficient potential method to suppress the alpha background from the {sup 227}Ac. In this paper, the charge comparison method (CCM) for alpha and gamma discrimination in LaBr{sub 3}:Ce is quantitatively analysed and compared with two other typical PSD methods using digital pulse processing. The algorithm parameters and discrimination efficiency are calculated for each method. Moreover, for the CCM, the correlation between the CCM feature value distribution and the total charge (energy) is studied, and a fitting equation for the correlation is inferred and experimentally verified. Using the equations, an energy-dependent threshold can be chosen to optimize the discrimination efficiency. Additionally, the experimental results show a potential application in low-activity high-energy γ measurement by suppressing the alpha background.

Neurexin-1β Binding to Neuroligin-1 Triggers the Preferential Recruitment of PSD-95 versus Gephyrin through Tyrosine Phosphorylation of Neuroligin-1

Directory of Open Access Journals (Sweden)

Grégory Giannone

2013-06-01

Full Text Available Adhesion between neurexin-1β (Nrx1β and neuroligin-1 (Nlg1 induces early recruitment of the postsynaptic density protein 95 (PSD-95 scaffold; however, the associated signaling mechanisms are unknown. To dissociate the effects of ligand binding and receptor multimerization, we compared conditions in which Nlg1 in neurons was bound to Nrx1β or nonactivating HA antibodies. Time-lapse imaging, fluorescence recovery after photobleaching, and single-particle tracking demonstrated that in addition to aggregating Nlg1, Nrx1β binding stimulates the interaction between Nlg1 and PSD-95. Phosphotyrosine immunoblots and pull-down of gephyrin by Nlg1 peptides in vitro showed that Nlg1 can be phosphorylated at a unique tyrosine (Y782, preventing gephyrin binding. Expression of Nlg1 point mutants in neurons indicated that Y782 phosphorylation controls the preferential binding of Nlg1 to PSD-95 versus gephyrin, and accordingly the formation of inhibitory and excitatory synapses. We propose that ligand-induced changes in the Nlg1 phosphotyrosine level control the balance between excitatory and inhibitory scaffold assembly during synapse formation and stabilization.

Application of PSD Review to a Portland Cement Manufacturing Operation, Texas Industries, Inc.

Science.gov (United States)

This document may be of assistance in applying the New Source Review (NSR) air permitting regulations including the Prevention of Significant Deterioration (PSD) requirements. This document is part of the NSR Policy and Guidance Database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Automatic or Blanket Exemptions for Excess Emissions During Startup, and Shutdowns Under PSD

Science.gov (United States)

This document may be of assistance in applying the New Source Review (NSR) air permitting regulations including the Prevention of Significant Deterioration (PSD) requirements. This document is part of the NSR Policy and Guidance Database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

PSD Applicability Determination for Multiple Owner/Operator Point Sources Within a Single Facility

Science.gov (United States)

This document may be of assistance in applying the New Source Review (NSR) air permitting regulations including the Prevention of Significant Deterioration (PSD) requirements. This document is part of the NSR Policy and Guidance Database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Technology for the Stars: Extending Our Reach. [Research and Technology: 1995 Annual Report of the Marshall Space Flight Center.

Science.gov (United States)

1996-01-01

Marshall Space Flight Center's (MSFC's) Advanced Studies, Research, Technology, and Technology Transfer projects are summarized in this report. The focus of the report is on the three spotlights at MSFC in 1995: space transportation technology, microgravity research, and technology transfer.

It counts who counts: an experimental evaluation of the importance of observer effects on spotlight count estimates

DEFF Research Database (Denmark)

Sunde, Peter; Jessen, Lonnie

2013-01-01

observers with respect to their ability to detect and estimate distance to realistic animal silhouettes at different distances. Detection probabilities were higher for observers experienced in spotlighting mammals than for inexperienced observers, higher for observers with a hunting background compared...... with non-hunters and decreased as function of age but were independent of sex or educational background. If observer-specific detection probabilities were applied to real counting routes, point count estimates from inexperienced observers without a hunting background would only be 43 % (95 % CI, 39...

PSD and NSPS Applicability Determination for Guardian Industries' Flat Glass Plant in Corsicana, Texas

Science.gov (United States)

This document may be of assistance in applying the New Source Review (NSR) air permitting regulations including the Prevention of Significant Deterioration (PSD) requirements. This document is part of the NSR Policy and Guidance Database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Design and Performance Analysis of Laser Displacement Sensor Based on Position Sensitive Detector (PSD)

International Nuclear Information System (INIS)

Song, H X; Wang, X D; Ma, L Q; Cai, M Z; Cao, T Z

2006-01-01

By using PSD as sensitive element, and laser diode as emitting element, laser displacement sensor based on triangulation method has been widely used. From the point of view of design, sensor and its performance were studied. Two different sensor configurations were described. Determination of the dimension, sensing resolution and comparison of the two different configurations were presented. The factors affecting the performance of the laser displacement sensor were discussed and two methods, which can eliminate the affection of dark current and environment light, are proposed

Development of the laser alignment system with PSD used for shaft calibration

Science.gov (United States)

Jiao, Guohua; Li, Yulin; Hu, Baowen

2006-02-01

Shaft calibration is an important technique during installation and maintenance of a rotating machine. It requires unique and high-precision measurement instruments with calculation capability, and relies on experience on heavy, high-speed, or high-temperature machines. A high-precision laser alignment system has been designed using PSD (Position Sensing Detector) to change traditional manual way of shaft calibration and to make the measurement easier and more accurate. The system is comprised of two small measuring units (Laser transmitter and detector) and a hand operated control unit or a PC. Such a laser alignment system has been used in some actual shaft alignment with offset resolution 1.5μm and angular resolution 0.1°.

High Dynamics and Precision Optical Measurement Using a Position Sensitive Detector (PSD in Reflection-Mode: Application to 2D Object Tracking over a Smart Surface

Directory of Open Access Journals (Sweden)

Ioan Alexandru Ivan

2012-12-01

Full Text Available When related to a single and good contrast object or a laser spot, position sensing, or sensitive, detectors (PSDs have a series of advantages over the classical camera sensors, including a good positioning accuracy for a fast response time and very simple signal conditioning circuits. To test the performance of this kind of sensor for microrobotics, we have made a comparative analysis between a precise but slow video camera and a custom-made fast PSD system applied to the tracking of a diffuse-reflectivity object transported by a pneumatic microconveyor called Smart-Surface. Until now, the fast system dynamics prevented the full control of the smart surface by visual servoing, unless using a very expensive high frame rate camera. We have built and tested a custom and low cost PSD-based embedded circuit, optically connected with a camera to a single objective by means of a beam splitter. A stroboscopic light source enhanced the resolution. The obtained results showed a good linearity and a fast (over 500 frames per second response time which will enable future closed-loop control by using PSD.

Bridging Professional Teacher Knowledge for Science and Literary Integration via Design-Based Research

Science.gov (United States)

Fazio, Xavier; Gallagher, Tiffany L.

2018-01-01

We offer insights for using design-based research (DBR) as a model for constructing professional development that supports curriculum and instructional knowledge regarding science and literacy integration. We spotlight experiences in the DBR process from data collected from a sample of four elementary teachers. Findings from interviews, focus…

The Effect of Dexmedetomidine on Cognitive Function and Protein Expression of Aβ, p-Tau, and PSD95 after Extracorporeal Circulation Operation in Aged Rats

Directory of Open Access Journals (Sweden)

Ying Zhang

2018-01-01

Full Text Available Postoperative cognitive dysfunction (POCD is a kind of serious neurologic complications and dexmedetomidine has a certain effect on POCD. However, functional mechanism of dexmedetomidine on POCD still remains unclear, so the research mainly studied the effect of dexmedetomidine on cognitive function and protein expression in hippocampus and prefrontal cortex cerebrospinal fluid after extracorporeal circulation operation in aged rats. We Found that, compared with POCD group, the cognitive function was improved in POCD + Dex group. We speculate that dexmedetomidine could improve the cognitive function after extracorporeal circulation operation in aged rats and Aβ, p-Tau, and PSD95 protein might have contributed to this favorable outcome.

Comparative study of large samples (2'' × 2'') plastic scintillators and EJ309 liquid with pulse shape discrimination (PSD) capabilities

International Nuclear Information System (INIS)

Iwanowska-Hanke, J; Moszynski, M; Swiderski, L; Sibczynski, P; Szczesniak, T; Krakowski, T; Schotanus, P

2014-01-01

In the paper we reported on the scintillation properties and pulse shape discrimination (PSD) performance of new plastic scintillators. The samples with dimension of 2 inches × 2 inches were tested: EJ299-34, EJ299-34G, EJ299-33 and EJ299-33G. They are the first commercially available plastics with neutron/gamma discrimination properties. The paper covers the measurements of emission spectra, photoelectron yield, analysis of the light pulse shapes originating from events related to gamma-rays and fast neutrons as well as neutron/gamma discrimination. The tested plastics are characterized by a photoelectron yield on a level of approximately 1600-2500 phe/MeV, depending on the sample. The highest value, measured for EJ299-34, is similar to the number of photoelectrons measured for EJ309 (2600 phe/MeV). The figure of merit (FOM) calculated for narrow energy cuts — indicating the PSD performance — showed that the PSD capabilities of the plastics are significantly lower than of EJ309. These scintillators are still under development in order to optimize the composition and manufacturing procedures. At this time the results obtained with the new plastics suggest their possible use as an alternative for liquid scintillators, especially if we consider their inflammability and non-toxicity

Recent Administrative and Judicial Decisions Regarding Consideration of Source Separation in Determining BACT Under PSD

Science.gov (United States)

This document may be of assistance in applying the New Source Review (NSR) air permitting regulations including the Prevention of Significant Deterioration (PSD) requirements. This document is part of the NSR Policy and Guidance Database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Applicability of PSD Requirements to the Wisconsin Electric Power Company Port Washington Life Extension Project

Science.gov (United States)

This document may be of assistance in applying the New Source Review (NSR) air permitting regulations including the Prevention of Significant Deterioration (PSD) requirements. This document is part of the NSR Policy and Guidance Database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Inclusion of Haul Road Emissions in PSD Applicability Determination for Coal Mine and Preparation Plant

Science.gov (United States)

This document may be of assistance in applying the New Source Review (NSR) air permitting regulations including the Prevention of Significant Deterioration (PSD) requirements. This document is part of the NSR Policy and Guidance Database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Request for Clarification of EPA Guidance on the Alternative Fuels Exemption under the PSD Program

Science.gov (United States)

This document may be of assistance in applying the New Source Review (NSR) air permitting regulations including the Prevention of Significant Deterioration (PSD) requirements. This document is part of the NSR Policy and Guidance Database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Response to Letter Requesting the EPA Repeal the Alternative Fuels Exemption in the PSD Regulations

Science.gov (United States)

This document may be of assistance in applying the New Source Review (NSR) air permitting regulations including the Prevention of Significant Deterioration (PSD) requirements. This document is part of the NSR Policy and Guidance Database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Applicability of the PSD Regulations to Certain Modifications Made by Cooper Tire and Rubber Company

Science.gov (United States)

This document may be of assistance in applying the New Source Review (NSR) air permitting regulations including the Prevention of Significant Deterioration (PSD) requirements. This document is part of the NSR Policy and Guidance Database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Simultaneous determination of environmental α-radionuclides using liquid scintillation counting combined with time interval analysis (TIA) and pulse shape discrimination (PSD)

International Nuclear Information System (INIS)

Hashimoto, T.; Sato, K.; Yoneyama, Y.; Fukuyama, N.

1997-01-01

Some improvements of the detection sensitivity in pulse time interval analysis (TIA) based on selective extraction of successively α-α correlated decay events within millisecond order from random or background events, were established by the utilization of PSD, to reject β/γ-pulses from α-ones and a simple chemical procedure of radium separation, together with the use of well resolved scintillator. By applying the PSD, the contribution of β-decay events was completely eliminated in both the α-spectra and the TIA distribution curves as well as the improvement into clear energy resolution and the enhancement of detection sensitivity for the TIA. As a result, the TIA and α-spectrometric analysis of 226 Ra-extract showed the existence of 223 Ra (Ac-series) and β/α-correlated events with correlated life (due to 0.16 ms due to 214 Bi(β)-> 214 Po(α)->) along with a singly well resolved α-peak to be useful for the determination of 226 Ra (U-series). The difference of half-lives (145 and 1.78 ms) due to 216 Po and 215 Po (direct daughters of 224 Ra for Th-series and 223 Ra for Ac-series, respectively) was also proven for the possibility of the simultaneous determination of both correlated events by using the TIA/PSD combined with chemical separation and liquid scintillation counting method. Finally, the simultaneous determination of three natural decay series, which include U-, Th- and Ac-series nuclides, have been conveniently carried out for some environmental samples using the present method combined with 225 Ra yield tracer (Np-series). (author)

Understanding Cancer Prognosis

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Full Text Available ... Partners & Collaborators Spotlight on Scientists Research Areas Cancer Biology Research Cancer Genomics Research Research on Causes of ... Collaborators Spotlight on Scientists NCI Research Areas Cancer Biology Cancer Genomics Causes of Cancer Diagnosis Prevention Screening & ...

Understanding Cancer Prognosis

Medline Plus

Full Text Available ... Laboratory for Cancer Research Partners & Collaborators Spotlight on Scientists Research Areas Cancer Biology Research Cancer Genomics Research ... Centers Frederick National Lab Partners & Collaborators Spotlight on Scientists NCI Research Areas Cancer Biology Cancer Genomics Causes ...

The BRiCS in the spotlight: a research agenda

OpenAIRE

SCAFFARDI LUCIA; FEDERICO VERONICA

2014-01-01

On November 6–7, 2014, the University of Parma (Italy) hosted a profound two-day discussion on the BRICS, i.e. Brazil, Russia, India, China and South Africa, a relatively new actor in the international arena, gathering the most innovative research and the leading experts and scholars.

PSD Applicability Determination for Power Boiler No. 4 at the Potlatch Corporation Facility in Lewiston, Idaho

Science.gov (United States)

This document may be of assistance in applying the New Source Review (NSR) air permitting regulations including the Prevention of Significant Deterioration (PSD) requirements. This document is part of the NSR Policy and Guidance Database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Simpson Pulp and Paper Mill in Tacoma, Washington, PSD applicability determination for Power Boiler No. 7

Science.gov (United States)

This document may be of assistance in applying the New Source Review (NSR) air permitting regulations including the Prevention of Significant Deterioration (PSD) requirements. This document is part of the NSR Policy and Guidance Database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Applicablitiy Determinations on the PSD 100 tpy Major Source Threshold Catergory for Fossil Fuel Boilers Industries

Science.gov (United States)

This document may be of assistance in applying the New Source Review (NSR) air permitting regulations including the Prevention of Significant Deterioration (PSD) requirements. This document is part of the NSR Policy and Guidance Database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Forum: Communication Activism Pedagogy. Communication Activism Pedagogy and Research: Communication Education Scholarship to Promote Social Justice

Science.gov (United States)

Frey, Lawrence R.; Palmer, David L.

2017-01-01

The recent formation of the National Communication Association's Activism and Social Justice Division puts a spotlight on the extent to which instructional communication and instructional communication research have advanced--or even should advance--the goals of social justice. To examine this issue, two of the leading scholars on this topic,…

Research Spotlight: Climate commitment in an uncertain world

Science.gov (United States)

Tretkoff, Ernie

2011-02-01

Even if humans immediately ceased emitting carbon dioxide (CO2) and other greenhouse gases, the planet would continue to warm, mainly due to thermal inertia of the world's oceans. This “climate commitment” has been of interest recently for both science and policy because it provides a measure of the minimum climate change the planet will face given human activity that has already occurred. Several studies have looked at what would happen if human emission of CO2 were halted, but these studies have overlooked the role of aerosols and non-CO2 greenhouse gases such as methane and nitrous oxide, which Armour and Roe include in a new study. If human emission stopped, atmospheric aerosols, which cool the planet by blocking light from the surface, would fall to preindustrial levels within weeks. However, non-CO2 greenhouse gases would remain in the atmosphere for decades to centuries, and elevated levels of CO2 would persist for millennia. (Geophysical Research Letters, doi:10.1029/2010GL045850, 2011)

Research Spotlight: The next big thing is actually small.

Science.gov (United States)

Garcia, Carlos D

2012-07-01

Recent developments in materials, surface modifications, separation schemes, detection systems and associated instrumentation have allowed significant advances in the performance of lab-on-a-chip devices. These devices, also referred to as micro total analysis systems (µTAS), offer great versatility, high throughput, short analysis time, low cost and, more importantly, performance that is comparable to standard bench-top instrumentation. To date, µTAS have demonstrated advantages in a significant number of fields including biochemical, pharmaceutical, military and environmental. Perhaps most importantly, µTAS represent excellent platforms to introduce students to microfabrication and nanotechnology, bridging chemistry with other fields, such as engineering and biology, enabling the integration of various skills and curricular concepts. Considering the advantages of the technology and the potential impact to society, our research program aims to address the need for simpler, more affordable, faster and portable devices to measure biologically active compounds. Specifically, the program is focused on the development and characterization of a series of novel strategies towards the realization of integrated microanalytical devices. One key aspect of our research projects is that the developed analytical strategies must be compatible with each other; therefore, enabling their use in integrated devices. The program combines spectroscopy, surface chemistry, capillary electrophoresis, electrochemical detection and nanomaterials. This article discusses some of the most recent results obtained in two main areas of emphasis: capillary electrophoresis, microchip-capillary electrophoresis, electrochemical detection and interaction of proteins with nanomaterials.

Genetic Underpinnings of Alopecia Areata

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Full Text Available ... News News from Labs @ NIAMS Newsletters Press Releases Research Briefs Spotlight on Research About NIAMS Asian Language Publications Portal en espanol ... Tied to Bone Mineral Density Loss Spotlight on Research | April 10, 2018 New Clues to the Causes ...

Applicability of PSD-WEPCO Rule for Existing Five Combined-Cycle Combustion Turbines at Cogen Technologies, Union County

Science.gov (United States)

This document may be of assistance in applying the New Source Review (NSR) air permitting regulations including the Prevention of Significant Deterioration (PSD) requirements. This document is part of the NSR Policy and Guidance Database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Simulations of a PSD Plastic Neutron Collar for Assaying Fresh Fuel

Energy Technology Data Exchange (ETDEWEB)

Hausladen, Paul [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Newby, Jason [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); McElroy, Robert Dennis [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

2016-11-01

The potential performance of a notional active coincidence collar for assaying uranium fuel based on segmented detectors constructed from the new PSD plastic fast organic scintillator with pulse shape discrimination capability was investigated in simulation. Like the International Atomic Energy Agency's present Uranium Neutron Collar for LEU (UNCL), the PSD plastic collar would also function by stimulating fission in the ²³⁵U content of the fuel with a moderated ²⁴¹Am/Li neutron source and detecting instances of induced fission via neutron coincidence counting. In contrast to the moderated detectors of the UNCL, the fast time scale of detection in the scintillator eliminates statistical errors due to accidental coincidences that limit the performance of the UNCL. However, the potential to detect a single neutron multiple times historically has been one of the properties of organic scintillator detectors that has prevented their adoption for international safeguards applications. Consequently, as part of the analysis of simulated data, a method was developed by which true neutron-neutron coincidences can be distinguished from inter-detector scatter that takes advantage of the position and timing resolution of segmented detectors. Then, the performance of the notional simulated coincidence collar was evaluated for assaying a variety of fresh fuels, including some containing burnable poisons and partial defects. In these simulations, particular attention was paid to the analysis of fast mode measurements. In fast mode, a Cd liner is placed inside the collar to shield the fuel from the interrogating source and detector moderators, thereby eliminating the thermal neutron flux that is most sensitive to the presence of burnable poisons that are ubiquitous in modern nuclear fuels. The simulations indicate that the predicted precision of fast mode measurements is similar to what can be achieved by the present UNCL in thermal mode. For example, the

New Genetic Susceptibility Factors for Sjögren's Syndrome Revealed

Science.gov (United States)

... Spotlight on Research Spotlight on Research New Genetic Susceptibility Factors for Sjögren’s Syndrome Revealed By Kirstie Saltsman, ... swallowing and speaking. “The identification of these genetic susceptibility factors opens up new avenues for understanding how ...

Global Monitoring of Mountain Glaciers Using High-Resolution Spotlight Imaging from the International Space Station

Science.gov (United States)

Donnellan, A.; Green, J. J.; Bills, B. G.; Goguen, J.; Ansar, A.; Knight, R. L.; Hallet, B.; Scambos, T. A.; Thompson, L. G.; Morin, P. J.

2013-12-01

Mountain glaciers around the world are retreating rapidly, contributing about 20% to present-day sea level rise. Numerous studies have shown that mountain glaciers are sensitive to global environmental change. Temperate-latitude glaciers and snowpack provide water for over 1 billion people. Glaciers are a resource for irrigation and hydroelectric power, but also pose flood and avalanche hazards. Accurate mass balance assessments have been made for only 280 glaciers, yet there are over 130,000 in the World Glacier Inventory. The rate of glacier retreat or advance can be highly variable, is poorly sampled, and inadequately understood. Liquid water from ice front lakes, rain, melt, or sea water and debris from rocks, dust, or pollution interact with glacier ice often leading to an amplification of warming and further melting. Many mountain glaciers undergo rapid and episodic events that greatly change their mass balance or extent but are sparsely documented. Events include calving, outburst floods, opening of crevasses, or iceberg motion. Spaceborne high-resolution spotlight optical imaging provides a means of clarifying the relationship between the health of mountain glaciers and global environmental change. Digital elevation models (DEMs) can be constructed from a series of images from a range of perspectives collected by staring at a target during a satellite overpass. It is possible to collect imagery for 1800 targets per month in the ×56° latitude range, construct high-resolution DEMs, and monitor changes in high detail over time with a high-resolution optical telescope mounted on the International Space Station (ISS). Snow and ice type, age, and maturity can be inferred from different color bands as well as distribution of liquid water. Texture, roughness, albedo, and debris distribution can be estimated by measuring bidirectional reflectance distribution functions (BRDF) and reflectance intensity as a function of viewing angle. The non-sun-synchronous orbit

Investigation on the applicability of Piety's on-line PSD-pattern recognition algorithm to boiling detection by neutron-noise at a swimming-pool reactor

International Nuclear Information System (INIS)

Behringer, K.; Spiekerman, G.; Yadigaroglu, G.

1984-11-01

The neutron noise signal of an initiation-of-boiling experiment performed at the SAPHIR reactor has been analyzed by the PSD-pattern recognition algorithm of Piety (1977); the results indicate that the onset of boiling can be detected by this method. Improved confidence statements for the statistical decision discriminants are given. (Auth.)

Court of Appeals Decision Upholding PSD Actual to Potential Applicability Rules Puerto Rican Cement Co., Inc. v. EPA

Science.gov (United States)

This document may be of assistance in applying the New Source Review (NSR) air permitting regulations including the Prevention of Significant Deterioration (PSD) requirements. This document is part of the NSR Policy and Guidance Database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Request for Concurrence as to Applicability of PSD and NSPS Regulations to Marblehead Lime Company Proposed Lime Plant

Science.gov (United States)

This document may be of assistance in applying the New Source Review (NSR) air permitting regulations including the Prevention of Significant Deterioration (PSD) requirements. This document is part of the NSR Policy and Guidance Database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

POWER SPECTRUM DENSITY (PSD ANALYSIS OF AUTOMOTIVE PEDAL-PAD

Directory of Open Access Journals (Sweden)

AHMED RITHAUDDEEN YUSOFF

2016-04-01

Full Text Available Vibration at the pedal-pad may contribute to discomfort of foot plantar fascia during driving. This is due to transmission of vibration to the mount, chassis, pedal, and then to the foot plantar fascia. This experimental study is conducted to determine the estimation of peak value using the power spectral density of the vertical vibration input at the foot. The power spectral density value is calculated based on the frequency range between 13 Hz to 18 Hz. This experiment was conducted using 12 subjects testing on three size of pedal-pads; small, medium and large. The result shows that peak value occurs at resonance frequency of 15 Hz. The PSD values at that resonance frequency are 0.251 (m/s2 2/Hz for small pedal-pad, followed by the medium pedal-pad is at 0.387 (m/s2 2/Hz and lastly for the large pedal-pad is at 0.483 (m/s22/Hz. The resultsindicate that during driving, the foot vibration when interact with the large pedal-pad contributed higher stimulus compared with the small and medium pedal-pad. The pedal-pad size plays an important role in the pedal element designs in terms of vibration-transfer from pedal-pads on the feet, particularly to provide comfort to the driver while driving.

Infertility Research at the NICHD

Science.gov (United States)

... All NICHD Spotlights Right Hand Navigation Newsroom News Digital Media Join NICHD Listservs ... Safe to Sleep® National Child & Maternal Health Education Program RELATED WEBSITES NIH.gov HHS.gov USA. ...

UCCB01-125, a dimeric inhibitor of PSD-95, reduces inflammatory pain without disrupting cognitive or motor performance: Comparison with the NMDA receptor antagonist MK-801

DEFF Research Database (Denmark)

Andreasen, Jesper T.; Bach, Anders; Gynther, Mikko

2013-01-01

Excessive N-Methyl-d-aspartate receptor (NMDAR)-dependent production of nitric oxide (NO) is involved in the development and maintenance of chronic pain states, and is mediated by postsynaptic density protein-95 (PSD-95). By binding to both the NMDAR and neuronal NO synthase (nNOS), PSD-95 mediates...... a specific coupling between NMDAR activation and NO production. NMDAR antagonism shows anti-nociceptive action in humans and animal models of chronic pain but is associated with severe disturbances of cognitive and motor functions. An alternative approach to modulate the NMDAR-related activity is to perturb......'s adjuvant (CFA) model of inflammatory pain. To examine side-effect profiles we also compared the effects of UCCB01-125 and MK-801 in tests of attention, long-term memory, and motor performance. When administered concurrently with CFA, both MK-801 and UCCB01-125 prevented the development of CFA...

CDKL5 ensures excitatory synapse stability by reinforcing NGL-1-PSD95 interaction in the postsynaptic compartment and is impaired in patient iPSC-derived neurons.

Science.gov (United States)

Ricciardi, Sara; Ungaro, Federica; Hambrock, Melanie; Rademacher, Nils; Stefanelli, Gilda; Brambilla, Dario; Sessa, Alessandro; Magagnotti, Cinzia; Bachi, Angela; Giarda, Elisa; Verpelli, Chiara; Kilstrup-Nielsen, Charlotte; Sala, Carlo; Kalscheuer, Vera M; Broccoli, Vania

2012-09-01

Mutations of the cyclin-dependent kinase-like 5 (CDKL5) and netrin-G1 (NTNG1) genes cause a severe neurodevelopmental disorder with clinical features that are closely related to Rett syndrome, including intellectual disability, early-onset intractable epilepsy and autism. We report here that CDKL5 is localized at excitatory synapses and contributes to correct dendritic spine structure and synapse activity. To exert this role, CDKL5 binds and phosphorylates the cell adhesion molecule NGL-1. This phosphorylation event ensures a stable association between NGL-1 and PSD95. Accordingly, phospho-mutant NGL-1 is unable to induce synaptic contacts whereas its phospho-mimetic form binds PSD95 more efficiently and partially rescues the CDKL5-specific spine defects. Interestingly, similarly to rodent neurons, iPSC-derived neurons from patients with CDKL5 mutations exhibit aberrant dendritic spines, thus suggesting a common function of CDKL5 in mice and humans.

Response to Request for Guidance on PSD Definition Referencing Cogeneration Gas Turbines that are Separated by One-Half Mile

Science.gov (United States)

This document may be of assistance in applying the New Source Review (NSR) air permitting regulations including the Prevention of Significant Deterioration (PSD) requirements. This document is part of the NSR Policy and Guidance Database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Determination of the Applicability of NSPS and PSD to Stationary Gas Turbines Converting From Middle Distillates to Natural Gas

Science.gov (United States)

This document may be of assistance in applying the New Source Review (NSR) air permitting regulations including the Prevention of Significant Deterioration (PSD) requirements. This document is part of the NSR Policy and Guidance Database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

A large 2D PSD for thermal neutron detection

International Nuclear Information System (INIS)

Knott, R.B.; Watt, G.; Boldeman, J.W.; Smith, G.C.

1996-01-01

A 2D PSD based on a MWPC has been constructed for a small angle neutron scattering instrument. The active area of the detector was 640 x 640 mm 2 . To meet the specifications for neutron detection efficiency and spatial resolution, and to minimize parallax, the gas mixture was 190 kPa 3 He plus 100 kPa CF 4 and the active volume had a thickness of 30 mm. The design maximum neutron count-rate of the detector was 10 5 events per second. The (calculated) neutron detection efficiency was 60% for 2 angstrom neutrons and the (measured) neutron energy resolution on the anode grid was typically 20% (fwhm). The location of a neutron detection event within the active area was determined using the wire-by-wire method: the spatial resolution (5 x 5 mm 2 ) was thereby defined by the wire geometry. A 16 channel charge-sensitive preamplifier/amplifier/comparator module has been developed with a channel sensitivity of 0.1 V/fC, noise linewidth of 0.4 fC (fwhm) and channel-to-channel cross-talk of less than 5%. The Proportional Counter Operating System (PCOS III) (LeCroy Corp USA) was used for event encoding. The ECL signals produced by the 16 channel modules were latched in PCOS III by a trigger pulse from the anode and the fast encoders produce a position and width for each event. The information was transferred to a UNIX workstation for accumulation and online display

Effects of the dimeric PSD-95 inhibitor UCCB01-144 in mouse models of pain, cognition and motor function

DEFF Research Database (Denmark)

Andreasen, Jesper T; Nasser, Arafat; Caballero-Puntiverio, Maitane

2016-01-01

NOS interaction has therefore been proposed as an alternative analgesic mechanism. We recently reported that UCCB01-125, a dimeric PSD-95 inhibitor with limited blood-brain-barrier permeability, reduced mechanical hypersensitivity in the complete Freund's adjuvant (CFA) inflammatory pain model, without disrupting...... of neuropathic pain. Potential cognitive effects of UCCB01-144 were examined using the social transmission of food preference (STFP) test and the V-maze test, and motor coordination was assessed with the rotarod test. UCCB01-144 (10mg/kg) reversed CFA-induced mechanical hypersensitivity after 1h, and completely...

On-line evaluation of position-sensitive detector (PSD) diffraction data

International Nuclear Information System (INIS)

Stansfield, R.F.D.; McIntyre, G.J.

1985-01-01

The amount of raw data accumulated in a single-crystal diffraction experiment using a two-dimensional Position Sensitive Detector is usually so large that it is impracticable to store it. It is therefore necessary to reduce each local three-dimensional array of counts to a Bragg intensity, in a time not longer than the average time that one reflection is active. The statistically optimum procedure comprises an estimation of the background from a large number of counts, and an integration of peak intensity within a suitable three-dimensional envelope. A typical on-line method is described, using as an example the D19 diffractometer at the Institut Max von Laue - Paul Langevin (ILL) high-flux reactor. Current methods of PSD data reduction are reviewed. These fall into three groups according to the basis of the method used to find the integration envelope: (a) statistical criteria, (b) three-dimensional sigma(I)/I analysis, and (c) pre-calculation of the resolution function. On-line data reduction imposes special requirements on diagnostics to check the precision of the reduced data, especially at the start of an experiment, when any peculiarities must be identified and allowed for in the data-reduction procedure. The diagnostic possibilities resulting from the comparison of local with global characteristics of the background and the integration envelope are discussed. (author)

A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage

DEFF Research Database (Denmark)

Bach, Anders*; Clausen, Bettina H; Møller, Magda

2012-01-01

Inhibition of the ternary protein complex of the synaptic scaffolding protein postsynaptic density protein-95 (PSD-95), neuronal nitric oxide synthase (nNOS), and the N-methyl-d-aspartate (NMDA) receptor is a potential strategy for treating ischemic brain damage, but high-affinity inhibitors are ...... of Tat-N-dimer (3 nmol/g) to mice subjected to focal cerebral ischemia reduces infarct volume with 40% and restores motor functions. Thus, Tat-N-dimer is a highly efficacious neuroprotective agent with therapeutic potential in stroke....

A large 2D PSD for thermal neutron detection

Energy Technology Data Exchange (ETDEWEB)

Knott, R.B.; Watt, G.; Boldeman, J.W. [Australian Nucl. Sci. and Tech. Organ., Menai, NSW (Australia). Phys. Div.; Smith, G.C. [Instrumentation Division, Brookhaven National Laboratory, Upton, NY 11973 (United States)

1997-06-21

A 2D PSD based on a MWPC has been constructed for a small angle neutron scattering instrument. The active area of the detector was 640 x 640 mm{sup 2}. To meet the specifications for neutron detection efficiency and spatial resolution, and to minimise parallax, the gas mixture was 190 kPa {sup 3}He plus 100 kPa CF{sub 4}, and the active volume had a thickness of 30 mm. The design maximum neutron count rate of the detector was 10{sup 5} events per second. The (calculated) neutron detection efficiency was 60% for 2 A neutrons and the (measured) neutron energy resolution on the anode grid was typically 20% (fwhm). The location of a neutron detection event within the active area was determined using the wire-by-wire method: the spatial resolution (5 x 5 mm{sup 2}) was thereby defined by the wire geometry. A 16-channel charge-sensitive preamplifier/amplifier/comparator module has been developed with a channel sensitivity of 0.1 V/fC, noise line width of 0.4 fC (fwhm) and channel-to-channel cross-talk of less than 5%. The proportional counter operating system (PCOS III) (LeCroy Corp, USA) was used for event encoding. The ECL signals produced by the 16 channel modules were latched in PCOS III by a trigger pulse from the anode and the fast encoders produce a position and width for each event. The information was transferred to a UNIX workstation for accumulation and online display. (orig.).

Sick of inequality: gender and support for paid sick days.

Science.gov (United States)

Lindemann, Danielle J; Houser, Linda; White, Karen

2015-01-01

The availability of paid sick days (PSD) is on the forefront of policy issues relating to women's health and well-being. Previous research regarding PSD and other forms of family-work balance legislation has linked access to paid time off from work for addressing one's own or another's health concerns to a range of health benefits for working women and their families. In general, public support for such policies is high, but little work has tested the extent to which support extends to PSD. Researchers have yet to engage in a rigorous statistical analysis of public opinion on PSD, including whether opinion varies by gender. Using data from a 2013 poll of adults in New Jersey (n = 925), we bridged this research gap by conducting the first multivariate analysis of public attitudes toward PSD. As expected, we found markedly high levels of support for PSD across all respondents, with a preponderance of most sociodemographic categories supporting proposed PSD legislation in New Jersey. We also found that gender was a strong predictor of support for PSD, with women significantly (odds ratio, 1.916; p ≤ .01) more likely than men to be in favor of such legislation. We discuss the implications of our findings for future work on PSD as well as for research concerning women, wellness, and work-life legislation more broadly. Published by Elsevier Inc.

Spotlight on GME/GHSE Supported Research

Science.gov (United States)

2017-12-07

hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and...utilize Pyrosequencing for their Protocol. Genetic Status of Genes via PCR & NGS ... 3.000.000.000bp 1 __ ____ _ 0_ .. -··. _ Ll...Construct Exome library for NGS . Sequence Exome via NGS . Store Exome data for future studies 1 bp 30,000,000 bp PCR DATA NGS DATA C

Korea-China Optical Technology Research Centre

Energy Technology Data Exchange (ETDEWEB)

Kim, Cheol Jung; Cha, H. K.; Rhee, Y. J. (and others)

2007-04-15

The main objectives of this project are to develop cooperative channel by personnel exchanges between industrial, educational and research partners of Korea and China on the fields of optical technologies which are the basis of optical industry and being spot-lighted as new industry of 21th century, and to raise the class of Korean optical technology up to world class by utilization of Chinese large facilities through the cooperative research between the optical technology institutions of both sides. To attain the goals mentioned above, we carried out the cooperative researches between the Korean and Chinese optical technology institutions in the following 7 fields; ? research cooperation between KAERI-SITP for the quantum structured far-IR sensor technology - research cooperation for the generation of femtosecond nuclear fusion induced neutrons - research cooperation between KAERI-AIOFM for laser environment analysis and remote sensing technology - research cooperation between KAERI-SIOM for advanced diode-pumped laser technology - cooperative research related on linear and nonlinear magneto-optical properties of advanced magnetic quantum structures - design of pico-second PW high power laser system and its simulation and - cooperative research related on the femto-second laser-plasma interaction physics.

Korea-China Optical Technology Research Centre

International Nuclear Information System (INIS)

Kim, Cheol Jung; Cha, H. K.; Rhee, Y. J.

2007-04-01

The main objectives of this project are to develop cooperative channel by personnel exchanges between industrial, educational and research partners of Korea and China on the fields of optical technologies which are the basis of optical industry and being spot-lighted as new industry of 21th century, and to raise the class of Korean optical technology up to world class by utilization of Chinese large facilities through the cooperative research between the optical technology institutions of both sides. To attain the goals mentioned above, we carried out the cooperative researches between the Korean and Chinese optical technology institutions in the following 7 fields; ? research cooperation between KAERI-SITP for the quantum structured far-IR sensor technology - research cooperation for the generation of femtosecond nuclear fusion induced neutrons - research cooperation between KAERI-AIOFM for laser environment analysis and remote sensing technology - research cooperation between KAERI-SIOM for advanced diode-pumped laser technology - cooperative research related on linear and nonlinear magneto-optical properties of advanced magnetic quantum structures - design of pico-second PW high power laser system and its simulation and - cooperative research related on the femto-second laser-plasma interaction physics

Computer networks for financial activity management, control and statistics of databases of economic administration at the Joint Institute for Nuclear Research

International Nuclear Information System (INIS)

Tyupikova, T.V.; Samoilov, V.N.

2003-01-01

Modern information technologies urge natural sciences to further development. But it comes together with evaluation of infrastructures, to spotlight favorable conditions for the development of science and financial base in order to prove and protect legally new research. Any scientific development entails accounting and legal protection. In the report, we consider a new direction in software, organization and control of common databases on the example of the electronic document handling, which functions in some departments of the Joint Institute for Nuclear Research

Response to Letter Regarding the Louisiana Department of Environmental Protection's Position on the PSD Significant Emission Level for ODS at Existing Major Sources

Science.gov (United States)

This document may be of assistance in applying the New Source Review (NSR) air permitting regulations including the Prevention of Significant Deterioration (PSD) requirements. This document is part of the NSR Policy and Guidance Database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Putting the learner in the spotlight – Future directions for English teachers

Directory of Open Access Journals (Sweden)

Anne P A Swan

2013-10-01

Full Text Available This paper asserts that English teachers’ understanding of their professionalism enables them to ‘put the learner in the spotlight’ through their highly-developed awareness of local contexts of English use. Changing attitudes to English language teacher identity include a revaluation of the’ native-non-native speaker’ dichotomy which is fast becoming irrelevant as teachers assert new identities based on factors such as professional beliefs about their teaching, understanding their students’ needs and understanding the role of English in their contexts. In a globalising world, these aspects no longer require ‘so-called’ native speaker skills, such as pronunciation and knowledge of ‘English’ culture. In fact, dwelling at length on the issues surrounding native and non-native speaker teacher identity tends to cloud understanding of what qualities English teachers need. Interviews with multilingual teachers of English, working in a variety of countries, have revealed an understanding of the diminishing importance of the ‘native speaker’ and the concomitant growth in the confidence of the multilingual teacher. This confidence has been acquired through depth of linguistic knowledge, through observance of other cultures, and through resistance to the encroachment of English by finding a place for the language which satisfies the needs of multilingual users without requiring subservience. In discovering these strengths of multilingual teachers, I show how stepping outside the boundaries of one’s own limited environment allows English language teachers, wherever they come from, to develop a truly enlightened international professionalism which puts learners firmly in the spotlight.

Research and Development Report, Fiscial Year 1989-1990.

Energy Technology Data Exchange (ETDEWEB)

United States. Bonneville Power Administration.

1991-08-01

Since the 1940s, the Bonneville Power Administrative (BPA), has sought to advance an efficient system to provide the Pacific Northwest region with safe, reliable, and cost-effective electrical power. Research and development (R D) activities support that mission. Each biennium, R D managers issue a digest report of the various programs and activities in each of the technological arenas. The report covers a few projects, considered as yielding particularly significant results, as spotlights. Others are described less fully; in some cases with a simple annotation. The report's divisions correspond to the major categories of R D projects: fish and wildlife, energy resources, and transmission technology. 18 figs., 4 tabs.

Provider self-disclosure during contraceptive counseling.

Science.gov (United States)

McLean, Merritt; Steinauer, Jody; Schmittdiel, Julie; Chan, Pamela; Dehlendorf, Christine

2017-02-01

Provider self-disclosure (PSD) - defined as providers making statements regarding personal information to patients - has not been well characterized in the context of contraceptive counseling. In this study, we describe the incidence, content and context of contraceptive PSD. This mixed methods analysis used data from the Provider-Patient Contraceptive Counseling study, for which 349 family planning patients were recruited from 2009 to 2012 from six clinics in the San Francisco Bay Area. Audio-recordings from their visits were analyzed for the presence or absence of PSD, and those visits with evidence of PSD were analyzed using qualitative methods. The associations of patient and provider demographics and patient satisfaction measures, obtained from survey data, with PSD were analyzed using bivariable and multivariable analyses. Thirty-seven percent of providers showed evidence of PSD during at least one visit, and PSD occurred in 9% of clinic visits. Fifty-four percent of PSD statements were about intrauterine devices. About half of PSD statements occurred prior to the final selection of the contraceptive method and appeared to influence the choice of method. In post-visit surveys, all patients who reported receiving PSD considered it to be appropriate, and patient-reported PSD was not statistically associated with measures of patient satisfaction. This study provides some support for the appropriateness of PSD during family planning encounters, at least as practiced during the sampled visits. Further research could explore whether this counseling strategy has an impact on patients' ability to identify the best contraceptive methods for them. In this study, PSD did not have a demonstrated negative effect on the provider-patient relationship. In almost half of visits, PSD appeared to influence patients' choice of a method; whether this influence is beneficial needs further research. Copyright © 2017 Elsevier Inc. All rights reserved.

Detection of boiling by Piety's on-line PSD-pattern recognition algorithm applied to neutron noise signals in the SAPHIR reactor

International Nuclear Information System (INIS)

Spiekerman, G.

1988-09-01

A partial blockage of the cooling channels of a fuel element in a swimming pool reactor could lead to vapour generation and to burn-out. To detect such anomalies, a pattern recognition algorithm based on power spectra density (PSD) proposed by Piety was further developed and implemented on a PDP 11/23 for on-line applications. This algorithm identifies anomalies by measuring the PSD on the process signal and comparing them with a standard baseline previously formed. Up to 8 decision discriminants help to recognize spectral changes due to anomalies. In our application, to detect boiling as quickly as possible with sufficient sensitivity, Piety's algorithm was modified using overlapped Fast-Fourier-Transform-Processing and the averaging of the PSDs over a large sample of preceding instantaneous PSDs. This processing allows high sensitivity in detecting weak disturbances without reducing response time. The algorithm was tested with simulation-of-boiling experiments where nitrogen in a cooling channel of a mock-up of a fuel element was injected. Void fractions higher than 30 % in the channel can be detected. In the case of boiling, it is believed that this limit is lower because collapsing bubbles could give rise to stronger fluctuations. The algorithm was also tested with a boiling experiment where the reactor coolant flow was actually reduced. The results showed that the discriminant D5 of Piety's algorithm based on neutron noise obtained from the existing neutron chambers of the reactor control system could sensitively recognize boiling. The detection time amounts to 7-30 s depending on the strength of the disturbances. Other events, which arise during a normal reactor run like scrams, removal of isotope elements without scramming or control rod movements and which could lead to false alarms, can be distinguished from boiling. 49 refs., 104 figs., 5 tabs

World nuclear power once again in the spotlight. Comments on the 13th Pacfic Basin Nuclear Conference

International Nuclear Information System (INIS)

Zang Mingchang; Ruan Keqiang

2004-01-01

This paper comments on The 13th Pacific Basin Nuclear Conference held in Shenzhen, China, on October 21/25, 2002 and summarizes some key papers presented in the Conference and viewpoints from their following discussions, which indicates that nuclear power in the world is once again in the spotlight. The Conference shows that in the coming 50 years the roadmap to develop nuclear energy would be divided into two stages: Near-Term Deployment by 2010-2015, some advanced designs were developed for Utilities; Generation IV Program, its overall goal is to identify and develop next-generation nuclear power systems that could be deployed over the next 30 years to help meet the world's energy needs throughout the 21st century. Some visions is the future, such as co-generation of electricity and space heating or desalination, and combination of Generation IV and so-called Hydrogen Economy-the use of hydrogen in vehicle transport to replace petroleum, were presented. As a primary energy source nuclear power is particularly well suited to hydrogen production, offering the almost unique position of large-scale hydrogen production with near-zero emissions. (authors)

Research Notes - An Introduction to Openness and Evolvability Assessment

Science.gov (United States)

2016-08-01

in a “box and line” diagram illustrating groups of functionality that are considered individual granules, along with indications of any...http://www.mitre.org/work/tech_transfer/pdf/se_capability.pdf, 1996. 6. USDATA Corporation - Adobe Customer Spotlight, Adobe Corporation, http

NCI Core Open House Shines Spotlight on Supportive Science and Basic Research | Poster

Science.gov (United States)

The lobby of Building 549 at NCI at Frederick bustled with activity for two hours on Tuesday, May 1, as several dozen scientists and staff gathered for the NCI Core Open House. The event aimed to encourage discussion and educate visitors about the capabilities of the cores, laboratories, and facilities that offer support to NCI’s Center for Cancer Research.

Performance of coincidence-based PSD on LiF/ZnS Detectors for Multiplicity Counting

Energy Technology Data Exchange (ETDEWEB)

Robinson, Sean M.; Stave, Sean C.; Lintereur, Azaree; Siciliano, Edward R.; Cowles, Christian C.; Kouzes, Richard T.; Behling, Richard S.

2016-10-06

Abstract: Mass accountancy measurement is a nuclear nonproliferation application which utilizes coincidence and multiplicity counters to verify special nuclear material declarations. With a well-designed and efficient detector system, several relevant parameters of the material can be verified simultaneously. 6LiF/ZnS scintillating sheets may be used for this purpose due to a combination of high efficiency and short die-away times in systems designed with this material, but involve choices of detector geometry and exact material composition (e.g., the addition of Ni-quenching in the material) that must be optimized for the application. Multiplicity counting for verification of declared nuclear fuel mass involves neutron detection in conditions where several neutrons arrive in a short time window, with confounding gamma rays. This paper considers coincidence-based Pulse-Shape Discrimination (PSD) techniques developed to work under conditions of high pileup, and the performance of these algorithms with different detection materials. Simulated and real data from modern LiF/ZnS scintillator systems are evaluated with these techniques and the relationship between the performance under pileup and material characteristics (e.g., neutron peak width and total light collection efficiency) are determined, to allow for an optimal choice of detector and material.

In vitro and in vivo effects of a novel dimeric inhibitor of PSD-95 on excitotoxicity and functional recovery after experimental traumatic brain injury

DEFF Research Database (Denmark)

Sommer, Jens Bak; Bach, Anders; Rytter, Hana Malá

2017-01-01

weeks post-trauma, spatial learning and memory were assessed in a water maze, and at 3 months, brains were removed for estimation of lesion volumes. Overall, neither treatment with UCCB01-147 nor MK-801 resulted in significant improvements of cognition and histopathology after CCI. Although MK-801......PSD-95 inhibitors have been shown to be neuroprotective in stroke, but have only to a very limited extent been evaluated in the treatment of traumatic brain injury (TBI) that has pathophysiological mechanisms in common with stroke. The aims of the current study were to assess the effects of a novel...

Research Spotlight: Model suggests path to ending the ongoing Haitian cholera epidemic

Science.gov (United States)

Schultz, Colin

2011-05-01

Since early November 2010 a deadly cholera epidemic has been spreading across the Caribbean nation of Haiti, killing thousands of people and infecting hundreds of thousands. While infection rates are being actively monitored, health organizations have been left without a clear understanding of exactly how the disease has spread across Haiti. Cholera can spread through exposure to contaminated water, and the disease travels over long distances if an infected individual moves around the country. Using representations of these two predominant dispersion mechanisms, along with information on the size of the susceptible population, the number of infected individuals, and the aquatic concentration of the cholera-causing bacteria for more than 500 communities, Bertuzzo et al. designed a model that was able to accurately reproduce the progression of the Haitian cholera epidemic. (Geophysical Research Letters, doi:10.1029/2011GL046823, 2011)

Data acquisition systems for uses of multi-counter time analyzer and one-dimensional PSD pulse height analyzer to neutron scattering measurements

International Nuclear Information System (INIS)

Ono, Masayoshi; Tasaki, Seiji; Okamoto, Sunao

1989-01-01

A data acquisition system having the various modern electronic devices was designed and tested for practical use of neutron time-of-flight (TOF) measurements with multiple counters. The system is principally composed of TOF logic units (load-able up to 128 units) with a control unit and a conventional micro-computer. The TOF logic unit (main memory, 2048 ch, 24 bits/ch) demonstrates about 1.7 times higher efficiency for neutron counting rate per channel than the one by a conventional TOF logic unit. Meanwhile, some data-access functions of the TOF logic unit were applied to position sensitive analyzer of one-dimensional neutron PSD for small angle scattering. The analyzer was tested with use of pulse generator. The result shows good linearity. (author)

Sports, Global Politics, and Social Value Change: A Research Agenda

Directory of Open Access Journals (Sweden)

Lars Rensmann

2015-11-01

Full Text Available Despite their important role in forging, constructing and self-ascribing social identities and shaping popular culture, sports have long been a marginalized subject of social science inquiry, cultural studies, and research on international politics. Only in recent years this has begun to change. The article seeks to advance the still nascent but emerging cross-disciplinary field of research on sports and global politics in two ways: first, by addressing largely unexplored issues of sports, politics, and social conflicts, putting the spotlight on sociopolitical arenas beyond commercialized sports mega events, which have attracted most scholarly attention in contemporary research; and second, by generating hypotheses on the indirect political effects of sports cultures, in particular on the relationship between local social identities—reinforced through sports—and cosmopolitan value change. These interlinked spatial and substantive claims ground a new critical research framework and agenda: it examines sports as profoundly embedded in socioeconomic, cultural and political forms of rule and domination but also seeks to disclose sports’ emancipatory and subversive potential in advancing globalization from below.

Reshaping clinical science: Introduction to the Special Issue on Psychophysiology and the NIMH Research Domain Criteria (RDoC) initiative.

Science.gov (United States)

Patrick, Christopher J; Hajcak, Greg

2016-03-01

The National Institute of Mental Health's (NIMH) Research Domain Criteria (RDoC) initiative seeks to establish new dimensional conceptions of mental health problems, through the investigation of clinically relevant "process" constructs that have neurobiological as well as psychological referents. This special issue provides a detailed overview of the RDoC framework by NIMH officials Michael Kozak and Bruce Cuthbert, and spotlights RDoC-oriented investigative efforts by leading psychophysiological research groups as examples of how clinical science might be reshaped through application of RDoC principles. Accompanying commentaries highlight key aspects of the work by each group, and discuss reported methods/findings in relation to promises and challenges of the RDoC initiative more broadly. © 2016 Society for Psychophysiological Research.

Know Stroke: Know the Signs, Act in Time Video

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Full Text Available ... Professional Resources Campaign Partners Research Programs Español Research Spotlight The NINDS conducts stroke research and clinical trials at its laboratories and clinics ...

Research-based Curricula in the Context of 21st Century Data Science

Science.gov (United States)

Fox, P. A.

2017-12-01

When the Informatics revolution began again a little more than 10 years ago (longer for bio-informatics) geosciences (or Earth and Space Sciences) was paying attention via international attention from the Electronic Geophysical Year (eGY) and related endeavours (IPY, IYPE, IHY). The research agenda was in the spotlight, or moreso what Earth and Space Science informatics, cast in emergent escience or cyber-infrastructures, could benefit from was the main focus of attention and funding. At the time almost all "Xinformatics" efforts were novel in their discipline or traditionally defined. However, a broader research and education agenda was clearly needed. At the same time, a much more cross-disciplinary field; data science emerged. In this presentation, we relate the development, delivery and assessment of research oriented informatics, data science and their specializations into geoscience education in generak and as undertaken at RPI over the last nine years. We conclude with a longitudinal view of the impacts on career paths in the 21st century

Simultaneous identification of optical constants and PSD of spherical particles by multi-wavelength scattering-transmittance measurement

Science.gov (United States)

Zhang, Jun-You; Qi, Hong; Ren, Ya-Tao; Ruan, Li-Ming

2018-04-01

An accurate and stable identification technique is developed to retrieve the optical constants and particle size distributions (PSDs) of particle system simultaneously from the multi-wavelength scattering-transmittance signals by using the improved quantum particle swarm optimization algorithm. The Mie theory are selected to calculate the directional laser intensity scattered by particles and the spectral collimated transmittance. The sensitivity and objective function distribution analysis were conducted to evaluate the mathematical properties (i.e. ill-posedness and multimodality) of the inverse problems under three different optical signals combinations (i.e. the single-wavelength multi-angle light scattering signal, the single-wavelength multi-angle light scattering and spectral transmittance signal, and the multi-angle light scattering and spectral transmittance signal). It was found the best global convergence performance can be obtained by using the multi-wavelength scattering-transmittance signals. Meanwhile, the present technique have been tested under different Gaussian measurement noise to prove its feasibility in a large solution space. All the results show that the inverse technique by using multi-wavelength scattering-transmittance signals is effective and suitable for retrieving the optical complex refractive indices and PSD of particle system simultaneously.

Application of noninvasive brain stimulation for post-stroke dysphagia rehabilitation.

Science.gov (United States)

Wang, Zhuo; Song, Wei-Qun; Wang, Liang

2017-02-01

Noninvasive brain stimulation (NIBS), commonly consisting of transcranial magnetic stimulation (TMS), transcranial direct-current stimulation (tDCS), as well as paired associative stimulation (PAS), has attracted increased interest and been applied experimentally in the treatment of post-stroke dysphagia (PSD). This review presented a synopsis of the current research for the application of NIBS on PSD. The intention here was to understand the current research progress and limitations in this field and to stimulate potential research questions not yet investigated for the application of NIBS on patients with PSD. Here we successively reviewed advances of repetitive TMS (rTMS), tDCS, and PAS techniques on both healthy participants and PSD patients in three aspects, including scientific researches about dysphagia mechanism, applied studies about stimulation parameters, and clinical trials about their therapeutic effects. The techniques of NIBS, especially rTMS, have been used by the researchers to explore the different mechanisms between swallowing recovery and extremity rehabilitation. The key findings included the important role of intact hemisphere reorganization for PSD recovery, and the use of NIBS on the contra-lesional side as a therapeutic potential for dysphagia rehabilitation. Though significant results were achieved in most studies by using NIBS on swallowing rehabilitation, it is still difficult to draw conclusions for the efficacy of these neurostimulation techniques, considering the great disparities between studies. Copyright © 2016. Published by Elsevier Taiwan.

Biochemical investigations of the mechanism of action of small molecules ZL006 and IC87201 as potential inhibitors of the nNOS-PDZ/PSD-95-PDZ interactions

DEFF Research Database (Denmark)

Bach, Anders

2015-01-01

ZL006 and IC87201 have been presented as efficient inhibitors of the nNOS/PSD-95 protein-protein interaction and shown great promise in cellular experiments and animal models of ischemic stroke and pain. Here, we investigate the proposed mechanism of action of ZL006 and IC87201 using biochemical...... by interacting with the β-finger of nNOS-PDZ. Our findings have implications for further medicinal chemistry efforts of ZL006, IC87201 and analogues, and challenge the general and widespread view on their mechanism of action....

Baseline Bone Mineral Density Measurements Key to Future Testing Intervals

Science.gov (United States)

... Research | April 3, 2018 Optimizing Steroid Treatment for Duchenne Muscular Dystrophy Spotlight on Research | March 8, 2018 The Role of the Microbiota in Eczema: Findings Suggest That Striking ...

Genetic Underpinnings of Alopecia Areata

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Full Text Available ... Research | April 10, 2018 New Clues to the Causes of Lupus Spotlight on Research | April 3, 2018 ... Skin Diseases is to support research into the causes, treatment, and prevention of arthritis and musculoskeletal and ...

Understanding Cancer Prognosis

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Full Text Available ... Extramural Research Bioinformatics and Cancer NCI-Designated Cancer Centers Frederick National Laboratory for Cancer Research Partners & Collaborators ... Extramural Research Bioinformatics and Cancer NCI-Designated Cancer Centers Frederick National Lab Partners & Collaborators Spotlight on Scientists ...

Know Stroke: Know the Signs, Act in Time Video

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Full Text Available ... Professional Resources Campaign Partners Research Programs Español Research Spotlight The NINDS conducts stroke research and clinical ... history of stroke. Dr. Galen Henderson, Harvard Medical School, Brigham and Women's Hospital: "Strokes are preventable, they ...

Lewy Body Digest eNewsletter

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... resources Join the fight against LBD! Donate Lewy Digest Click here to subscribe today to receive regular ... research in Lewy body dementia. April 2018 Lewy Digest Month of Compassion Caregiver Spotlight Research Centers of ...

Final Determinations Regarding the Applicability of the Clean Air Act's NSPS and PSD Requirements to the Proposed Life Extension Project at the Port Washington Steam Electric Generating Station Owned by WEPCO

Science.gov (United States)

This document may be of assistance in applying the New Source Review (NSR) air permitting regulations including the Prevention of Significant Deterioration (PSD) requirements. This document is part of the NSR Policy and Guidance Database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

The Use of Polysymptomatic Distress Categories in the Evaluation of Fibromyalgia (FM) and FM Severity

NARCIS (Netherlands)

Wolfe, Frederick; Walitt, Brian T.; Rasker, Johannes J.; Katz, Robert S.; Häuser, Winfried

2015-01-01

Objective The polysymptomatic distress (PSD) scale is derived from variables used in the 2010 American College of Rheumatology (ACR) fibromyalgia (FM) criteria modified for survey and clinical research. The scale is useful in measuring the effect of PSD over the full range of pain-related clinical

Special Issue on Gender and Writing | Gender and literacy issues and research: Placing the spotlight on writing

Directory of Open Access Journals (Sweden)

Judy M. Parr

2012-03-01

Full Text Available In this introduction to a special issue of the Journal of Writing Research, we review four decades of research, bringing writing to the forefront in conversations devoted to gender and literacy. We identify the impetus for much of the research on gender and writing and situate the four articles in this special issue within three themes: gender patterns in what and how students write, cognitive and socio-cultural factors influencing gender differences in student writing, and attempts to provide alternatives to stereotypical gender patterns in student writing. These interdisciplinary themes, further developed within the four articles, underscore the need to consider gender as a complex social, cognitive and linguistic characteristic of both reading and writing.

What Treatment Options Are Available for Male Infertility?

Science.gov (United States)

... Research Information Find a Study Resources and Publications Klinefelter Syndrome (KS) Condition Information NICHD Research Information Find a ... infertility? Related A-Z Topics Infertility and Fertility Klinefelter Syndrome (KS) Sexually Transmitted Diseases (STDs) NICHD News Spotlights ...

GSD Update: Year in Review: Spotlight on 2013 research by the Grassland, Shrubland and Desert Ecosystems Science Program

Science.gov (United States)

Deborah M. Finch

2014-01-01

In this issue of the GSD Update, we take a look back at selected studies of the Grassland, Shrubland and Desert Ecosystems Science Program (GSD) that depict its strengths and focus areas. Significant results of recent research and science delivery by GSD scientists are highlighted. We feature program research that lines up with the strategic research priorities of the...

GSD Update: Year in Review: Spotlight on 2015 Research by the Grassland, Shrubland and Desert Ecosystems Science Program

Science.gov (United States)

Deborah. Finch

2016-01-01

In this issue of the GSD Update, we take a look back at selected studies of the Grassland, Shrubland and Desert Ecosystems Science Program (GSD) that depict its strengths and focus areas. Significant results of recent research and science delivery by GSD scientists are highlighted. We feature program research that lines up with the strategic research...

Genetic Underpinnings of Alopecia Areata

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Full Text Available ... Early Antiretroviral Therapy in HIV Patients Tied to Bone Mineral Density Loss Spotlight on Research | April 10, ... Press Releases NIH researchers crack mystery behind rare bone disorder Press Release | April 11, 2018 NIH program ...

Winter precipitation particle size distribution measurement by Multi-Angle Snowflake Camera

Science.gov (United States)

Huang, Gwo-Jong; Kleinkort, Cameron; Bringi, V. N.; Notaroš, Branislav M.

2017-12-01

From the radar meteorology viewpoint, the most important properties for quantitative precipitation estimation of winter events are 3D shape, size, and mass of precipitation particles, as well as the particle size distribution (PSD). In order to measure these properties precisely, optical instruments may be the best choice. The Multi-Angle Snowflake Camera (MASC) is a relatively new instrument equipped with three high-resolution cameras to capture the winter precipitation particle images from three non-parallel angles, in addition to measuring the particle fall speed using two pairs of infrared motion sensors. However, the results from the MASC so far are usually presented as monthly or seasonally, and particle sizes are given as histograms, no previous studies have used the MASC for a single storm study, and no researchers use MASC to measure the PSD. We propose the methodology for obtaining the winter precipitation PSD measured by the MASC, and present and discuss the development, implementation, and application of the new technique for PSD computation based on MASC images. Overall, this is the first study of the MASC-based PSD. We present PSD MASC experiments and results for segments of two snow events to demonstrate the performance of our PSD algorithm. The results show that the self-consistency of the MASC measured single-camera PSDs is good. To cross-validate PSD measurements, we compare MASC mean PSD (averaged over three cameras) with the collocated 2D Video Disdrometer, and observe good agreements of the two sets of results.

Research Spotlight: Satellites monitor air pollutant emissions in China

Science.gov (United States)

Tretkoff, Ernie

A new satellite study verifies that Chinese emission control efforts did reduce power plant emissions of sulfur dioxide (SO2), a harmful gas that causes acid rain and can form sulfate aerosols; these aerosols play an important role in the climate system by affecting clouds and precipitation patterns and altering the amount of sunlight that is reflected away from Earth.

Monitoring highway assets using remote sensing technology : research spotlight.

Science.gov (United States)

2014-04-01

Collecting inventory data about roadway assets is a critical part of : MDOTs asset management efforts, which help the department operate, : maintain and upgrade these assets cost-effectively. Federal law requires : that states develop a risk-based...

From Visions of Grandeur to Grand Failure

DEFF Research Database (Denmark)

Geraldi, Joana; Stingl, Verena

2016-01-01

Berlin Brandenburg Airport exemplifies the impact of poor decisions in projects. Extant research on behavioural decision making in project contexts offers a variety of explanations for poor decisions. However, the research sheds only spotlights on the field. It could benefit from a stronger cover...... will give rise to the development of an integrated behavioural decision making theories for temporary organisations.......Berlin Brandenburg Airport exemplifies the impact of poor decisions in projects. Extant research on behavioural decision making in project contexts offers a variety of explanations for poor decisions. However, the research sheds only spotlights on the field. It could benefit from a stronger...... coverage of theories in cognitive and social psychology and integration of findings and concepts across theoretical traditions. Drawing on the developments of Behavioural Strategy, this paper proposes the concept of ‘Behavioural Projects’ as a host of the growing body of research on behavioural decision...

Gout in the spotlight.

Science.gov (United States)

So, Alexander

2008-01-01

Understanding how uric acid crystals provoke inflammation is crucial to improving our management of acute gout. It is well known that urate crystals stimulate monocytes and macrophages to elaborate inflammatory cytokines, but the tissue response of the synovium is less well understood. Microarray analysis of mRNA expression by these lining cells may help to delineate the genes that are modulated. Employing a murine air-pouch model, a number of genes expressed by innate immune cells were found to be rapidly upregulated by monosodium urate crystals. These findings provide new research avenues to investigate the physiopathology of gouty inflammation, and may eventually lead to new therapeutic targets in acute gout.

Physics in the Spotlight

Science.gov (United States)

2000-10-01

CERN, ESA and ESO Put Physics On Stage [1] Summary Can you imagine how much physics is in a simple match of ping-pong, in throwing a boomerang, or in a musical concert? Physics is all around us and governs our lives. The World-Wide Web and mobile communication are only two examples of technologies that have rapidly found their way from science into the everyday life. [Go to Physics On Stage Website at CERN] But who is going to maintain these technologies and develop new ones in the future? Probably not young Europeans, as recent surveys show a frightening decline of interest in physics and technology among Europe's citizens, especially schoolchildren. Fewer and fewer young people enrol in physics courses at university. The project "Physics on Stage" tackles this problem head on. An international festival of 400 physics educators from 22 European countries [2] gather at CERN in Geneva from 6 to 10 November to show how fascinating and entertaining physics can be . In a week-long event innovative methods of teaching physics and demonstrations of the fun that lies in physics are presented in a fair, in 10 spectacular performances, and presentations. Workshops on 14 key themes will give the delegates - teachers, professors, artists and other physics educators - the chance to discuss and come up with solutions for the worrying situation of disenchantment with Science in Europe. The European Science and Technology Week 2000 "Physics on Stage" is a joint project organised by the European Organisation for Nuclear Research (CERN) , the European Space Agency (ESA) and the European Southern Observatory (ESO) , Europe's leading physics research organisations. This is the first time that these three organisations have worked together in such close collaboration to catalyse a change in attitude towards science and technology education. Physics on Stage is funded in part by the European Commission and happens as an event in the European Science and Technology Week 2000, an

Know Stroke: Know the Signs, Act in Time Video

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Full Text Available ... National Institutes of Health National Institute of Neurological Disorders and Stroke Search this site: ... Spotlight The NINDS conducts stroke research and clinical trials at its laboratories ...

At the service of cutting-edge research

CERN Multimedia

ISS Magazine

2012-01-01

Many external companies work for CERN, including ISS, a market leader in the area of service provision. In an article, republished in full below, due to appear in the next edition of the ISS Magazine, the company puts CERN in the spotlight. Take a moment to discover how an external company sees CERN.   CERN is a world-renowned research facility. ISS, with its 100-strong workforce ensures that the scientists can concentrate 100% on science. Since 1954, scientists from all corners of the globe have been seeking out the origins of the Universe at CERN, the European Laboratory for Particle Physics. CERN has been responsible for ground-breaking discoveries and inventions, such as the Worldwide Web in 1989. The task entrusted to ISS by CERN is as unusual as the laboratory is extraordinary. What started as a simple window-cleaning contract in 1967 has now evolved into a complex logistics operation. Keeping storage costs low For the past 25 years, ISS have been organising CERN's stores management...

Mapping Tropical Rainforest Canopy Disturbances in 3D by COSMO-SkyMed Spotlight InSAR-Stereo Data to Detect Areas of Forest Degradation

Directory of Open Access Journals (Sweden)

Manuela Hirschmugl

2013-02-01

Full Text Available Assessment of forest degradation has been emphasized as an important issue for emission calculations, but remote sensing based detecting of forest degradation is still in an early phase of development. The use of optical imagery for degradation assessment in the tropics is limited due to frequent cloud cover. Recent studies based on radar data often focus on classification approaches of 2D backscatter. In this study, we describe a method to detect areas affected by forest degradation from digital surface models derived from COSMO-SkyMed X-band Spotlight InSAR-Stereo Data. Two test sites with recent logging activities were chosen in Cameroon and in the Republic of Congo. Using the full resolution COSMO-SkyMed digital surface model and a 90-m resolution Shuttle Radar Topography Mission model or a mean filtered digital surface model we calculate difference models to detect canopy disturbances. The extracted disturbance gaps are aggregated to potential degradation areas and then evaluated with respect to reference areas extracted from RapidEye and Quickbird optical imagery. Results show overall accuracies above 75% for assessing degradation areas with the presented methods.

Sex & Bugs & Rock ‘n Roll - Getting creative about public engagement

NARCIS (Netherlands)

Sayer, E.J.; Featherstone, H.C.; Gosling, W.D.

2014-01-01

Public engagement is widely recognized as a key priority for achieving societal support for research. We spotlight creativity in public engagement as a way of reaching wider audiences and incentivising researcher involvement, demonstrating some of the possibilities with a recent initiative to engage

GSD Update: Year in Review: Spotlight on 2017 Research by the Grassland, Shrubland and Desert Ecosystems Science Program

Science.gov (United States)

Deborah M. Finch

2018-01-01

In this issue of the GSD Update, we feature selected studies of the RMRS Grassland, Shrubland and Desert Ecosystems Science Program (GSD) that focus on the theme of fire. Significant results of recent research and science delivery by GSD scientists are highlighted. We feature program research that lines up with the strategic priorities and goals of the USDA Forest...

Centro de Biologia Molecular "Severo Ochoa": a center for basic research into Alzheimer's disease.

Science.gov (United States)

Avila, Jesus; Hernandez, Felix; Wandosell, Francisco; Lucas, Jose J; Esteban, Jose A; Ledesma, M Dolores; Bullido, Maria J

2010-01-01

One important aspect of studies carried out at the Center for Molecular Biology "Severo Ochoa" is focused on basic aspects of Alzheimer's disease, mainly the search for suitable therapeutic targets for this disorder. Several groups at the Center are involved in these studies, and, in this spotlight, the work they are carrying out will be described.

Lack of interest in physical activity - individual and environmental attributes in adults across Europe: The SPOTLIGHT project.

Science.gov (United States)

Carraça, Eliana V; Mackenbach, Joreintje D; Lakerveld, Jeroen; Rutter, Harry; Oppert, Jean-Michel; De Bourdeaudhuij, Ilse; Compernolle, Sofie; Roda, Célina; Bardos, Helga; Teixeira, Pedro J

2018-06-01

A considerable proportion of European adults report little or no interest in physical activity. Identifying individual-level and environmental-level characteristics of these individuals can help designing effective interventions and policies to promote physical activity. This cross-sectional study additionally explored associations between level of interest and physical activity, after controlling for other individual and environmental variables. Measures of objective and perceived features of the physical environment of residence, self-reported physical activity and other lifestyle behaviors, barriers towards physical activity, general health, and demographics were obtained from 5205 European adults participating in the 2014 online SPOTLIGHT survey. t-Tests, chi-square tests, and generalized estimating equations with negative binomial log-link function were conducted. Adults not interested in physical activity reported a higher BMI and a lower self-rated health, were less educated, and to a smaller extent female and less frequently employed. They were more prone to have less healthy eating habits, and to perceive more barriers towards physical activity. Only minor differences were observed in environmental attributes: the non-interested were slightly more likely to live in neighborhoods objectively characterized as less aesthetic and containing more destinations, and perceived as less functional, safe, and aesthetic. Even after controlling for other individual and environmental factors, interest in physical activity remained a significant correlate of physical activity, supporting the importance of this association. This study is among the first to describe characteristics of individuals with reduced interest in physical activity, suggesting that (lack of) interest is a robust correlate of physical activity in several personal and environmental conditions. Copyright © 2018 Elsevier Inc. All rights reserved.

Impairment of male reproductive function after sleep deprivation.

Science.gov (United States)

Alvarenga, Tathiana A; Hirotsu, Camila; Mazaro-Costa, Renata; Tufik, Sergio; Andersen, Monica L

2015-05-01

To evaluate the influence of sleep loss on sexual behavior, hormone levels, sperm parameters, and testis-specific gene expression in male rats. Experimental research. Animal laboratory. Male adult Wistar-Hannover rats. Sexually experienced rats were subjected to paradoxic sleep deprivation (PSD) for 96 hours or sleep restriction (SR) for 21 days or kept in their home cage as control (CTRL). Sexual behavior, hormone levels, sperm parameters and expression of stress and nitric oxide-related genes were evaluated. PSD significantly decreased sexual behavior compared with the CTRL group, whereas SR had no effect. The PSD group had significantly lower testosterone levels than the CTRL group. Both PSD and SR groups had lower sperm viabilities than the CTRL group. The decrease in the number of live sperm compared with the CTRL group was larger in the PSD group than in the SR group. Regarding testicular gene expression, both PSD and SR led to an increase of iNOS and hydroxysteroid 11β-dehydrogenase 1 expressions compared with the CTRL group. These changes were more pronounced in the PSD group. A significant increase in endothelial nitric oxide synthase expression was observed in the PSD groups compared with the CTRL group. No changes were observed in dimethylarginine dimethylaminohydrolase 1 and casein kinase 2β-polypeptide expressions. Sleep loss can promote marked changes in the male reproductive system of rats, particularly affecting spermatic function in part by interfering in the testicular nitric oxide pathway. Copyright © 2015 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

Novel Insights Into Causes of Scleroderma Offer Potential New Treatment Strategies

Science.gov (United States)

... Spotlight on Research Novel Insights Into Causes of Scleroderma Offer Potential New Treatment Strategies By Kirstie Saltsman, Ph.D. | December 15, 2013 In scleroderma, immune cells invade the skin, but the role ...

Genetic Disease Foundation

Science.gov (United States)

... has used its fundraising efforts to help further research programs at Mount Sinai. Spotlight: Gaucher Gaucher Disease is the most common of the lipid storage diseases. Learn about its symptoms, how it ...

Know Stroke: Know the Signs, Act in Time Video

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Full Text Available ... and Stroke Search this site: Home About the Campaign Stroke Materials » Brochures » Toolkits and Posters » Radio PSAs » ... and TV PSAs » Widgets » Infographics Health Professional Resources Campaign Partners Research Programs Español Research Spotlight The ...

Application of the EGM Method to a LED-Based Spotlight: A Constrained Pseudo-Optimization Design Process Based on the Analysis of the Local Entropy Generation Maps

Directory of Open Access Journals (Sweden)

Enrico Sciubba

2011-06-01

Full Text Available In this paper, the entropy generation minimization (EGM method is applied to an industrial heat transfer problem: the forced convective cooling of a LED-based spotlight. The design specification calls for eighteen diodes arranged on a circular copper plate of 35 mm diameter. Every diode dissipates 3 W and the maximum allowedtemperature of the plate is 80 °C. The cooling relies on the forced convection driven by a jet of air impinging on the plate. An initial complex geometry of plate fins is presented and analyzed with a commercial CFD code that computes the entropy generation rate. A pseudo-optimization process is carried out via a successive series of design modifications based on a careful analysis of the entropy generation maps. One of the advantages of the EGM method is that the rationale behind each step of the design process can be justified on a physical basis. It is found that the best performance is attained when the fins are periodically spaced in the radial direction.

Modified Protein Improves Vitiligo Symptoms in Mice

Science.gov (United States)

... Vitiligo Symptoms in Mice Spotlight on Research Modified Protein Improves Vitiligo Symptoms in Mice By Colleen Labbe, ... D., Ph.D., Rush University. Altering a key protein involved in the development of vitiligo may protect ...

Insights Into Severe Form of Dwarfism Could Lead to New Treatment Strategies

Science.gov (United States)

... Spotlight on Research Insights Into Severe Form of Dwarfism Could Lead to New Treatment Strategies By Colleen ... a mutation that causes a severe form of dwarfism have led to a better understanding of the ...

Physical Therapy to Treat Torn Meniscus Comparable to Surgery for Many Patients

Science.gov (United States)

... to Surgery for Many Patients Spotlight on Research Physical Therapy to Treat Torn Meniscus Comparable to Surgery ... to avoid surgery and achieve comparable relief from physical therapy, according to a recent, multisite study funded ...

International Team Identifies Biomarker for Scleroderma

Science.gov (United States)

... Spotlight on Research International Team Identifies Biomarker for Scleroderma By Kirstie Saltsman, Ph.D. | May 5, 2014 ... molecule correlates with a more severe form of scleroderma, a chronic autoimmune disorder that involves the abnormal ...

Genetic Underpinnings of Alopecia Areata

Medline Plus

Full Text Available ... Briefs Shorttakes Spotlight on Research About NIAMS Asian Language Publications Portal en espanol Community Outreach Initiative ... Outreach | April 19, 2018 Early Antiretroviral Therapy in HIV Patients Tied to Bone Mineral Density ...

Identification of nuclear reactor characteristics by the reactor noise analysis

International Nuclear Information System (INIS)

Yashima, Hideyuki

1980-01-01

Reactor noise analysis method was applied to TRIGA II Research Reactor (Atomic Research Laboratory, Musashi Institute of Technology) and computed power spectral density (PSD) from the CIC current record. PSD has provided many valuable informations regarding to the reactor kinetics, including the effect of control rods vibration. Another information of neutron physics parameters were obtained and this result was compared with the parameter which was formerly measured by the Feynman-α experiment. Through these experiments we could find overall frequency characteristics of TRIGA II Reactor. (author)

Human embryo research and the 14-day rule.

Science.gov (United States)

Pera, Martin F

2017-06-01

In many jurisdictions, restrictions prohibit the culture of human embryos beyond 14 days of development. However, recent reports describing the successful maintenance of embryos in vitro to this stage have prompted many in the field to question whether the rule is still appropriate. This Spotlight article looks at the original rationale behind the 14-day rule and its relevance today in light of advances in human embryo culture and in the derivation of embryonic-like structures from human pluripotent stem cells. © 2017. Published by The Company of Biologists Ltd.

Mindfulness-Based Stress Reduction

Science.gov (United States)

... R S T U V W X Y Z Mindfulness-Based Stress Reduction (MBSR) Information 6 Things You ... Disease and Dementia (12/20/13) Research Spotlights Mindfulness-Based Stress Reduction, Cognitive-Behavioral Therapy Shown To ...

What is HD - Huntington's Disease?

Science.gov (United States)

... Spotlight: Dr. Rocio Gomez-Pastor Advocacy Huntington’s Disease Parity Act Affordable Care Act Social Security Administration Research ( ... affected gene is 50%. Inheritance is independent of gender. Genetic Testing & Family Planning People at-risk for ...

Stages of Huntington's Disease (HD)

Science.gov (United States)

... Spotlight: Dr. Rocio Gomez-Pastor Advocacy Huntington’s Disease Parity Act Affordable Care Act Social Security Administration Research ( ... affected gene is 50%. Inheritance is independent of gender. Genetic Testing & Family Planning People at-risk for ...

Safe Use of Complementary Health Products and Practices

Science.gov (United States)

... to Rip-offs: Don't Fall for Health Fraud Scams ( FDA ) Research Spotlights Latest Findings From CREST- ... links Twitter Read our disclaimer about external links Facebook Read our disclaimer about external links YouTube Read ...

The Research of Screw Thread Parameter Measurement Based on Position Sensitive Detector and Laser

International Nuclear Information System (INIS)

Tong, Q B; Ding, Z L; Chen, J C; Ai, L L; Yuan, F

2006-01-01

A technique and system of measuring screw thread parameter based on the theory of laser measurement is presented in this paper, which can be carried out the automated measurement of screw thread parameter. An inspection instrument was designed and produced, which included exterior imaging system of optical path, transverse displacement measurement system, axial displacement measurement system, and a module to deal with, control and assess the data in the upper system. The inspection and estimate of the screw thread contour curve were completed by using position sensitive device (PSD) as photoelectric detector to measure the coordinate data of the screw thread contour curve in the transverse section, and using precise raster to measure the axial displacement of the precision worktable under the screw thread test criterion., computer can gives a measured result according to coordinate data of the screw thread obtained by PSD. The relation between measured spot and image is established, and optimum design of the system organization are introduced, including the image length of receiving lens focal length optical system and the choice of PSD , and some main factor affected measuring precision are analyzed. The experimental results show that the measurement uncertainty of screw thread minor diameter can reach 0. 5μm, which can meet most requests for the measurement of screw thread parameter

Aspen's Global 100: Beyond Grey Pinstripes 2009-2010--Preparing MBAs for Social and Environmental Stewardship

Science.gov (United States)

Aspen Institute, 2009

2009-01-01

Beyond Grey Pinstripes is a research survey and alternative ranking of business schools that spotlights innovative full-time MBA programs leading the way in integrating social and environmental stewardship into their curriculum and scholarly research. These schools are preparing today's students--tomorrow's leaders--for future market realities by…

Genetic Underpinnings of Alopecia Areata

Medline Plus

Full Text Available ... Clues to the Causes of Lupus Spotlight on Research | April 3, 2018 NIAMS Update — March 29, 2018 NIAMS Update | March 29, 2018 Communicating Science to the Public: Context and Curiosity Letter from ...

Software offers transparent, straightforward assessment of pavement additives : research spotlight.

Science.gov (United States)

2015-04-01

Adding new materials to pavement layers is a proven technique to : improve performance. Many types of additivesfrom engineered : polymers and acids to recycled pavement, crumb rubber, shingles : and glasshave been used to help construct better ...

Soil stabilization with recycled materials improves subgrade performance : research spotlight.

Science.gov (United States)

2016-02-29

The use of recycled materials for subgrade stabilization can provide the support needed for construction vehicle loading and more typical long-term traffic loading. This is a particular need in Michigan due to the prevalence of weak subgrade soils. U...

Spreading the word about the quick clearance law : research spotlight.

Science.gov (United States)

2012-09-01

Motorists traditionally were taught to leave : their vehicles in place after a crash occurred : to make it easier for police to reconstruct : the incident and evaluate who was at fault. : However, the practice of leaving vehicles in : the roadway can...

CURE Scholar Spotlight - Dr. Brady

Science.gov (United States)

Donita C. Brady, a Research Associate Senior at the Department of Pharmacology and Cancer Biology at Duke University, is investigating the role that copper plays in cell growth and tumor biology. Inspired by her mentor Christopher Counter, a cancer biologist, and Dennis Thiele, a copper biologist, at Duke University, Brady has a unique interest in the way copper interacts with protein pathways, such as the BRAF (a human gene that directs cell growth)-MEK-ERK pathway, which is a major target for targeted cancer therapies because the BRAF gene is mutated 60% of the time in melanoma.

Genetic Underpinnings of Alopecia Areata

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Full Text Available ... Briefs Shorttakes Spotlight on Research About NIAMS Asian Language Publications Portal en espanol Community Outreach Initiative Breadcrumb Home News Room Welcome to the redesigned NIAMS website! Find out what it has to offer you. ...

The post-synaptic density of human postmortem brain tissues: an experimental study paradigm for neuropsychiatric illnesses.

Directory of Open Access Journals (Sweden)

Chang-Gyu Hahn

Full Text Available Recent molecular genetics studies have suggested various trans-synaptic processes for pathophysiologic mechanisms of neuropsychiatric illnesses. Examination of pre- and post-synaptic scaffolds in the brains of patients would greatly aid further investigation, yet such an approach in human postmortem tissue has yet to be tested. We have examined three methods using density gradient based purification of synaptosomes followed by detergent extraction (Method 1 and the pH based differential extraction of synaptic membranes (Methods 2 and 3. All three methods separated fractions from human postmortem brains that were highly enriched in typical PSD proteins, almost to the exclusion of pre-synaptic proteins. We examined these fractions using electron microscopy (EM and verified the integrity of the synaptic membrane and PSD fractions derived from human postmortem brain tissues. We analyzed protein composition of the PSD fractions using two dimensional liquid chromatography tandem mass spectrometry (2D LC-MS/MS and observed known PSD proteins by mass spectrometry. Immunoprecipitation and immunoblot studies revealed that expected protein-protein interactions and certain posttranscriptional modulations were maintained in PSD fractions. Our results demonstrate that PSD fractions can be isolated from human postmortem brain tissues with a reasonable degree of integrity. This approach may foster novel postmortem brain research paradigms in which the stoichiometry and protein composition of specific microdomains are examined.

Optimal design of waveform digitisers for both energy resolution and pulse shape discrimination

Science.gov (United States)

Cang, Jirong; Xue, Tao; Zeng, Ming; Zeng, Zhi; Ma, Hao; Cheng, Jianping; Liu, Yinong

2018-04-01

Fast digitisers and digital pulse processing have been widely used for spectral application and pulse shape discrimination (PSD) owing to their advantages in terms of compactness, higher trigger rates, offline analysis, etc. Meanwhile, the noise of readout electronics is usually trivial for organic, plastic, or liquid scintillator with PSD ability because of their poor intrinsic energy resolution. However, LaBr3(Ce) has been widely used for its excellent energy resolution and has been proven to have PSD ability for alpha/gamma particles. Therefore, designing a digital acquisition system for such scintillators as LaBr3(Ce) with both optimal energy resolution and promising PSD ability is worthwhile. Several experimental research studies about the choice of digitiser properties for liquid scintillators have already been conducted in terms of the sampling rate and vertical resolution. Quantitative analysis on the influence of waveform digitisers, that is, fast amplifier (optional), sampling rates, and vertical resolution, on both applications is still lacking. The present paper provides quantitative analysis of these factors and, hence, general rules about the optimal design of digitisers for both energy resolution and PSD application according to the noise analysis of time-variant gated charge integration.

Genetic Underpinnings of Alopecia Areata

Medline Plus

Full Text Available ... 10, 2018 New Clues to the Causes of Lupus Spotlight on Research | April 3, 2018 NIAMS Update — ... 2018 NIH program to accelerate therapies for arthritis, lupus releases first datasets Press Release | February 22, 2018 ...

Post-Traumatic Stress Disorder

Science.gov (United States)

... Know About Mind and Body Approaches for Health Problems Facing Military Personnel and Veterans Research Spotlights Acupuncture May Help ... Clinical Digest: Mind and Body Approaches for Health Problems in Military Personnel and Veterans Clinical Digest: Stress and Relaxation ...

One-dimensional position sensitive detector based on photonic crystals

International Nuclear Information System (INIS)

Xi Feng; Qin Lan; Xue Lian; Duan Ying

2013-01-01

Position sensitive detectors (PSDs) are an important class of optical sensors which utilizes the lateral photovoltaic effect (LPVE). According to the operation principle of PSD, we demonstrate that LPVE can be enhanced by lengthening the lifetime of photo-generated carriers. A PSD based on photonic crystals (PCs) composed of MgF 2 and InP is proposed and designed. The transmittances of the defect PC and the reflectance of the perfect PC in the PSD are obtained with transfer matrix method. The theoretical research on the designed device shows that LPVE is enhanced by improving the transmittance of the defect PC and the reflectance of the perfect PC to lengthen the lifetime of photo-generated carriers. (authors)

Working Paper 6: A conceptual framework to guide research on ...

International Development Research Centre (IDRC) Digital Library (Canada)

2010-12-16

Dec 16, 2010 ... ... attention to the role of the private sector as an engine for economic growth and poverty reduction in developing and transition economies. ... Growth and Poverty ( GGP ) programme initiative, and to help IDRC to reach a ... Then, it explores the ways in which donor agencies support PSD and presents an ...

Implantación de guías de buenas prácticas en España. Programa de centros comprometidos con la excelencia en cuidados / Best Practice Guidelines Implementation in Spain. Best Practice Spotlight Organizations / Implementação de manuais sobre boas práticas na Espanha. Programa dos Centros comprometidos com a excelência no atendimento

Directory of Open Access Journals (Sweden)

Laura Albornos-Muñoz, BS.

2015-03-01

centros comprometidos con la excelencia en cuidados. MedUNAB 2015; 17 (3: xx-xx]. Introduction: The Best Practice Guidelines Implementation Programme, called in Spain “Centros Comprometidos con la Excelencia en Cuidados®”, started in 2010 thanks to the collaboration between the Nursing and Healthcare Research Unit (Investén-isciii, in Spain, the Spanish Collaborating Centre of the Joanna Briggs Institute for evidence based healthcare, and the Registered Nurses’ Association of Ontario (RNAO, Canada. It is based on the same fundaments of Best Practice Spotlight Organizations (BPSO® Program, initiated by RNAO, in 1999, in Canada. Objective: To describe the implementation of Best Practice Guidelines developed by RNAO in the context of Centros Comprometidos con la Excelencia en Cuidados® Program. The program aims to promote, facilitate and support the implementation, evaluation and sustainability of nursing best practices, for the period 2012-2014. Methodology and Results: Eight healthcare institutions and one university were selected to implement RNAO Best Practice Guidelines aligned with their needs. Twenty-four months into the implementation Programme healthcare professionals have been trained, work teams have been established, nursing care protocols and records have been developed or updated, and process and patient results have been systematically evaluated. Also, all main achievements of the Programme have been actively disseminated. Conclusions: Candidates centers committed to excellence in cuidados® are working hard and the results are starting to show positive, with a growing culture of evidence-based care, and the promotion of research and the start of work collaborative networking. [Albornos-Muñoz L, González-María E, Moreno-Casbas T. Best Practice Guidelines Implementation in Spain. Best Practice Spotlight Organizations. MedUNAB 2015; 17 (3: xx-xx]. Introdução: O programa para implementar Manuais de Boas Práticas, chamados na Espanha de Centros

Regulating the health care workforce: next steps for research.

Science.gov (United States)

Davies, Celia

2004-01-01

This article explores the recent ferment surrounding professional self-regulation in medicine and other health professions. It reviews the academic literature and sets out an agenda for research. The first section considers definitions, acknowledging the particularly complex regulatory maze in UK health care at present, in which professional self-regulation is only one part. The second section reviews academic writing, currently dispersed among the disciplines. 'The logic of light touch regulation', a feature of the 19th century establishment of the General Medical Council, can perhaps shed light on present debates. Alongside the intense political spotlight on regulation in the wake of the Bristol case, consumer-led research and consumer pressure to rethink the principles of regulation has emerged. This is examined in the third section. Finally, themes for research are advanced. First, there is a need to explore the changing relationship between the state and professions and implications, not only for the professions but for health care more broadly. Second, calls for a new professionalism need to be given clearer content. Third, the moves towards more lay involvement in regulatory bodies need study. Fourth, questions of human rights and professional registers must be explored. Fundamental questions of what professional self-regulation can hope to achieve and where it fits in relation to government ambitions as a whole, remain unresolved. Alongside the work programme of the new overarching regulator, there may well be scope for a new style of public enquiry covering the whole territory of regulation.

Go4Life

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Full Text Available ... YouTube Red Get YouTube TV Best of YouTube Music Sports Gaming Movies TV Shows News Live Spotlight ... Disease Play all NIA videos on Alzheimer's disease research 4:00 Play next Play now How Alzheimer's ...

Batteries and Energy Storage | Argonne National Laboratory

Science.gov (United States)

Skip to main content Argonne National Laboratory Toggle Navigation Toggle Search Energy Batteries Security User Facilities Science Work with Us Energy Batteries and Energy Storage Energy Systems Modeling Transportation SPOTLIGHT Batteries and Energy Storage Argonne's all- encompassing battery research program spans

Grantee Spotlight: Elisa Rodriguez, Ph.D., M.S.

Science.gov (United States)

Dr. Elisa M. Rodriguez tests the feasibility of community-based participatory research approaches to engaging Hispanics, African Americans, and the medically underserved in the Buffalo, NY area in biospecimen donation for cancer research.

QTLs for resistance to Phomopsis seed decay are associated with days to maturity in soybean (Glycine max).

Science.gov (United States)

Sun, Suli; Kim, Moon Young; Van, Kyujung; Lee, Yin-Won; Li, Baodu; Lee, Suk-Ha

2013-08-01

Phomopsis seed decay (PSD), primarily caused by Phomopsis longicolla, is a major contributor to poor soybean seed quality and significant yield loss, particularly in early maturing soybean genotypes. However, it is not yet known whether PSD resistance is associated with early maturity. This study was conducted to identify quantitative trait loci (QTLs) for resistance to PSD and days to maturity using a recombinant inbred line (RIL) population derived from a cross between the PSD-resistant Taekwangkong and the PSD-susceptible SS2-2. Based on a genetic linkage map incorporating 117 simple sequence repeat markers, QTL analysis revealed two and three QTLs conferring PSD resistance and days to maturity, respectively, in the RIL population. Two QTLs (PSD-6-1 and PSD-10-2) for PSD resistance were identified in the intervals of Satt100-Satt460 and Sat_038-Satt243 on chromosomes 6 and 10, respectively. Two QTLs explained phenotypic variances in PSD resistance of 46.3 and 14.1 %, respectively. At the PSD-6-1 QTL, the PSD-resistant cultivar Taekwangkong contributed the allele with negative effect decreasing the infection rate of PSD and this QTL does not overlap with any previously reported loci for PSD resistance in other soybean genotypes. Among the three QTLs for days to maturity, two (Mat-6-2 and Mat-10-3) were located at positions similar to the PSD-resistance QTLs. The identification of the QTLs linked to both PSD resistance and days to maturity indicates a biological correlation between these two traits. The newly identified QTL for resistance to PSD associated with days to maturity in Taekwangkong will help improve soybean resistance to P. longicolla.

Binaural noise reduction via cue-preserving MMSE filter and adaptive-blocking-based noise PSD estimation

Science.gov (United States)

Azarpour, Masoumeh; Enzner, Gerald

2017-12-01

Binaural noise reduction, with applications for instance in hearing aids, has been a very significant challenge. This task relates to the optimal utilization of the available microphone signals for the estimation of the ambient noise characteristics and for the optimal filtering algorithm to separate the desired speech from the noise. The additional requirements of low computational complexity and low latency further complicate the design. A particular challenge results from the desired reconstruction of binaural speech input with spatial cue preservation. The latter essentially diminishes the utility of multiple-input/single-output filter-and-sum techniques such as beamforming. In this paper, we propose a comprehensive and effective signal processing configuration with which most of the aforementioned criteria can be met suitably. This relates especially to the requirement of efficient online adaptive processing for noise estimation and optimal filtering while preserving the binaural cues. Regarding noise estimation, we consider three different architectures: interaural (ITF), cross-relation (CR), and principal-component (PCA) target blocking. An objective comparison with two other noise PSD estimation algorithms demonstrates the superiority of the blocking-based noise estimators, especially the CR-based and ITF-based blocking architectures. Moreover, we present a new noise reduction filter based on minimum mean-square error (MMSE), which belongs to the class of common gain filters, hence being rigorous in terms of spatial cue preservation but also efficient and competitive for the acoustic noise reduction task. A formal real-time subjective listening test procedure is also developed in this paper. The proposed listening test enables a real-time assessment of the proposed computationally efficient noise reduction algorithms in a realistic acoustic environment, e.g., considering time-varying room impulse responses and the Lombard effect. The listening test outcome

Reference air kerma and kerma-area product as estimators of peak skin dose for fluoroscopically guided interventions

International Nuclear Information System (INIS)

Kwon, Deukwoo; Little, Mark P.; Miller, Donald L.

2011-01-01

Purpose: To determine more accurate regression formulas for estimating peak skin dose (PSD) from reference air kerma (RAK) or kerma-area product (KAP). Methods: After grouping of the data from 21 procedures into 13 clinically similar groups, assessments were made of optimal clustering using the Bayesian information criterion to obtain the optimal linear regressions of (log-transformed) PSD vs RAK, PSD vs KAP, and PSD vs RAK and KAP. Results: Three clusters of clinical groups were optimal in regression of PSD vs RAK, seven clusters of clinical groups were optimal in regression of PSD vs KAP, and six clusters of clinical groups were optimal in regression of PSD vs RAK and KAP. Prediction of PSD using both RAK and KAP is significantly better than prediction of PSD with either RAK or KAP alone. The regression of PSD vs RAK provided better predictions of PSD than the regression of PSD vs KAP. The partial-pooling (clustered) method yields smaller mean squared errors compared with the complete-pooling method.Conclusion: PSD distributions for interventional radiology procedures are log-normal. Estimates of PSD derived from RAK and KAP jointly are most accurate, followed closely by estimates derived from RAK alone. Estimates of PSD derived from KAP alone are the least accurate. Using a stochastic search approach, it is possible to cluster together certain dissimilar types of procedures to minimize the total error sum of squares.

Association of serum 25-hydroxyvitamin D with symptoms of depression after 6 months in stroke patients.

Science.gov (United States)

Yue, Wei; Xiang, Lei; Zhang, Ya-Jing; Ji, Yong; Li, Xin

2014-11-01

Our aim was to determine whether there was a relationship between 25-hydroxyvitamin D (25[OH] D) and post-stroke depression (PSD). Two hundred and forty-four ischemic stroke patients admitted to the hospital within the first 24 h after stroke onset were consecutively recruited and followed up for 6 months. Clinical information was collected. Serum 25[OH] D levels were measured at baseline. Based on the symptoms, diagnoses of depression were made in accordance with DSM-IV criteria for depression at 6-month after stroke. At 6-month, 91 patients (37.3 %) showed depression and in 60 patients (24.6 %) this depression was classified as major. There was a significant difference in median serum 25[OH] D levels between PSD patients and no depression cases [8.3 (IQR, 6.8-9.5) vs. 15.6 (IQR, 13.2-20.3) ng/ml, respectively; P < 0.001]. Serum 25[OH] D levels ≤ 11.2 ng/ml were independently associated with PSD [odds ratio 10.32, 95 % confidence interval 4.97-28.63; P < 0.001], after adjusting for possible confounders. Serum 25[OH] D levels reduced at admission was found to be associated with PSD. Additional research is needed on vitamin D supplementation to improve the outcome of patients with PSD.

Sex & Bugs & Rock 'n Roll--getting creative about public engagement.

Science.gov (United States)

Sayer, Emma J; Featherstone, Helen C; Gosling, William D

2014-02-01

Public engagement is widely recognized as a key priority for achieving societal support for research. We spotlight creativity in public engagement as a way of reaching wider audiences and incentivising researcher involvement, demonstrating some of the possibilities with a recent initiative to engage the public with ecology at music festivals. Copyright © 2013 Elsevier Ltd. All rights reserved.

Neutrino physics in the spotlight

CERN Multimedia

2009-01-01

Following on from the Council recommendation made in Lisbon in 2006 and responding to the needs of a large community of scientists, CERN will organize the European Strategy for Future Neutrino Physics workshop on 1-3 October. One of the main goals of the workshop is to start establishing a roadmap for the coherent participation of Europe in neutrino physics."The format of the workshop will consist of invited talks to present the current situation and future possibilities; unlike other workshops, 30% of the time will be reserved for discussion", explains Ewa Rondio from the organising committee. "Resources for future neutrino experiments will be difficult to acquire. A coordinated approach and the participation of a large community of interested scientists are undoubtedly crucial factors". The workshop will be the opportunity to highlight the areas where substantial research and development activities are required in order to design the facilities of the next decade. "The w...

Experimental Treatment for Duchenne Muscular Dystrophy Gets Boost from Existing Medication

Science.gov (United States)

... Boost from Existing Medication Spotlight on Research Experimental Treatment for Duchenne Muscular Dystrophy Gets Boost from Existing Medication By Colleen Labbe, M.S. | March 1, 2013 A mouse hanging on a wire during a test of muscle strength. Mice with a mutant dystrophin gene, which ...

In Situ Reductive Synthesis of Structural Supported Gold Nanorods in Porous Silicon Particles for Multifunctional Nanovectors.

Science.gov (United States)

Zhu, Guixian; Liu, Jen-Tsai; Wang, Yuzhen; Zhang, Dechen; Guo, Yi; Tasciotti, Ennio; Hu, Zhongbo; Liu, Xuewu

2016-05-11

Porous silicon nanodisks (PSD) were fabricated by the combination of photolithography and electrochemical etching of silicon. By using PSD as a reducing agent, gold nanorods (AuNR) were in situ synthesized in the nanopores of PSD, forming PSD-supported-AuNR (PSD/AuNR) hybrid particles. The formation mechanism of AuNR in porous silicon (pSi) was revealed by exploring the role of pSi reducibility and each chemical in the reaction. With the PSD support, AuNR exhibited a stable morphology without toxic surface ligands (CTAB). The PSD/AuNR hybrid particles showed enhanced plasmonic property compared to free AuNR. Because high-density "hot spots" can be generated by controlling the distribution of AuNR supported in PSD, surface-enhanced raman scattering (SERS) using PSD/AuNR as particle substrates was demonstrated. A multifunctional vector, PSD/AuNR/DOX, composed of doxorubicin (DOX)-loaded PSD/AuNR capped with agarose (agar), was developed for highly efficient, combinatorial cancer treatment. Their therapeutic efficacy was examined using two pancreatic cancer cell lines, PANC-1 and MIA PaCa-2. PSD/AuNR/DOX (20 μg Au and 1.25 μg DOX/mL) effectively destroyed these cells under near-IR laser irradiation (810 nm, 15 J·cm(-2) power, 90 s). Overall, we envision that PSD/AuNR may be a promising injectable, multifunctional nanovector for biomedical application.

Resolving the Origin of Pseudo-Single Domain Magnetic Behavior

Science.gov (United States)

Roberts, Andrew P.; Almeida, Trevor P.; Church, Nathan S.; Harrison, Richard J.; Heslop, David; Li, Yiliang; Li, Jinhua; Muxworthy, Adrian R.; Williams, Wyn; Zhao, Xiang

2017-12-01

The term "pseudo-single domain" (PSD) has been used to describe the transitional state in rock magnetism that spans the particle size range between the single domain (SD) and multidomain (MD) states. The particle size range for the stable SD state in the most commonly occurring terrestrial magnetic mineral, magnetite, is so narrow ( 20-75 nm) that it is widely considered that much of the paleomagnetic record of interest is carried by PSD rather than stable SD particles. The PSD concept has, thus, become the dominant explanation for the magnetization associated with a major fraction of particles that record paleomagnetic signals throughout geological time. In this paper, we argue that in contrast to the SD and MD states, the term PSD does not describe the relevant physical processes, which have been documented extensively using three-dimensional micromagnetic modeling and by parallel research in material science and solid-state physics. We also argue that features attributed to PSD behavior can be explained by nucleation of a single magnetic vortex immediately above the maximum stable SD transition size. With increasing particle size, multiple vortices, antivortices, and domain walls can nucleate, which produce variable cancellation of magnetic moments and a gradual transition into the MD state. Thus, while the term PSD describes a well-known transitional state, it fails to describe adequately the physics of the relevant processes. We recommend that use of this term should be discontinued in favor of "vortex state," which spans a range of behaviors associated with magnetic vortices.

Validation of fibromyalgia survey questionnaire and polysymptomatic distress scale in a Persian population.

Science.gov (United States)

Bidari, Ali; Ghavidel-Parsa, Banafsheh; Amir Maafi, Alireza; Montazeri, Ali; Ghalehbaghi, Babak; Hassankhani, Amir; Aarabi, Yasaman; Haghdoost, Afrooz

2015-12-01

The aim of this study was to assess validity of the fibromyalgia survey questionnaire (FSQ) and polysymptomatic distress scale (PSD) in an Iranian population. We also sought to classify the severity levels of fibromyalgia (FM) symptoms according to the PSD scale. Participants were divided into FM and non-FM chronic pain disorder groups according to expert physician diagnosis. Patients in both groups answered to Persian-translated version of FSQ, fibromyalgia impact questionnaire (FIQ) and Short-Form-12 (SF-12). Both 1990 ACR criteria and FSDC were assessed in participates of two groups. Internal consistency and construct validity were evaluated. There was good internal consistency measured by Cronbach's alpha (0.814 for FSQ). FSQ and its subscales correlated significantly with FIQ scores and SF-12 subscales, indicating acceptable construct validity. The concordance rates of FSQ with 1990 ACR criteria and expert diagnosis were 61.2 and 75.7, respectively (convergence validity). The mean score of PSD and its components in FM group were significantly more than in control groups (discriminative validity). Using lower PSD score cutoff (≥8.5) for the diagnosis of fibromyalgia appeared to be the most effective approach in our population. ROC analysis of the PSD scores revealed 8.5-11.5, 11.5-15 and more than 15, respectively, as a mild, moderate and severe FM. Persian version of FSQ was a valid instrument for application in survey research among Iranian patients with chronic pain disorders. The current study revealed that PSD could be used as a valid tool for assessment of symptoms intensity regardless of fibromyalgia diagnosis.

Get prepared for the spotlight

CERN Multimedia

2009-01-01

With the re-start of the LHC, not just the scientific community will have its eyes on CERN. Hundreds of journalists will continue to ensure high media coverage of the Lab’s activities. As the DG stated in his message in issue No.15 of The Bulletin, "we have a greater degree of responsibility in the way we communicate". The Media Training organized by the Press Office gives you the chance to learn how to do it.If you are a scientist, engineer, computer expert or in any way a person likely to interact with the media, you might get the chance to be involved in the activities of the Press Office, which welcomes over 500 journalists from all over the world every year. "We are looking for enthusiastic scientists, researchers, engineers and IT specialists who are eager to explain their work to journalists", explains Renilde Vanden Broeck, Press Officer. "Last year we dealt with more than 700 media on-site. A regular media visit covers the main activities of CERN, namely accelerat...

Business alignment in the procurement domain: a study of antecedents and determinants of supply chain performance.

NARCIS (Netherlands)

Mikalef, P.; Pateli, A.; Batenburg, R.; Wetering, R. van de

2014-01-01

With organizations now placing an increasing amount on attention on the management of their supply chain activities, the role of Information Technology (IT) in supporting these operations has been put in the spotlight. In spite of extensive research examining how IT can be employed in various

Improving mobility and transportation options for Michigan's rural seniors : research spotlight.

Science.gov (United States)

2012-12-01

Mobility challenges faced by older adults in : rural Michigan include long travel distances to obtain basic services or medical : care, and the limited availability of public, : private or volunteer transportation providers. Because of these challeng...

MDOT innovation leading to faster, longer-lasting pavement repairs : research spotlight.

Science.gov (United States)

2015-01-01

Current methods of patching pavement must evolve to meet increasing mobility demands. : To address this need, MDOT has been testing a new generation of rapid set full-depth : pavement repair materials. Initial results are promising. The new materials...

Objects but not concepts modulate the size of the attended region.

Science.gov (United States)

Goodhew, Stephanie C; Edwards, Mark

2017-07-01

Here we investigated the types of stimuli that modulate the size of the attentional spotlight. In particular, it has been previously shown that conceptual cues that either directly refer to or are semantically related to particular spatial locations can shift attention to that location (known as "conceptual cueing"). For example, reading the word sun or joy can shift attention upward whereas the word boot or hostile can shift attention downward. Here, therefore, we tested whether words could modulate the size of the attended area. Across five experiments, we found that words that either directly referred to, or were abstractly associated with, particular sizes (small versus large) did not change the size of the attentional spotlight, whereas the presence of differently sized stimuli did, as evidenced by faster responses to targets when the spotlight is small than when it is large. This suggests that physical but not conceptual inducers can modulate the size of the attentional spotlight. This highlights an important difference between the regulation of spotlight size and shifts of attention, supporting the notion that they are subserved by distinct mechanisms.

Project PHaEDRA: Preserving Harvard's Early Data and Research in Astronomy

Science.gov (United States)

Bouquin, Daina; Frey, Katie; Henneken, Edwin; McEachern, Maria; McGrath, Alex; Guarracino, Daniel; Koch, Jennifer; Damon, James; Brownell, Eric; Smith-Zrull, Lindsay; Daina Bouquin

2018-01-01

Material originally produced during 19th and early 20th century by researchers at the Harvard College Observatory (HCO) was recently re-discovered in the HCO Astronomical Plate Stacks collection. This material helps represent the history of the HCO and acts as an irreplaceable primary source on the evolution of observation methods and astronomy as a science. The material is also relevant to the history of women in science as the collection contains logbooks and notebooks produced by the Harvard Computers, women who have come back into the spotlight due to the recent release of books like "The Glass Universe," "Rise of the Rocket Girls," and movies like "Hidden Figures". To ensure that this remarkable set of items is as accessible and useful as possible Wolbach Library, in collaboration with the SAO/NASA Astrophysics Data System (ADS) and others, is working to catalog, digitize, and preserve the entire collection. The material is also being transcribed by volunteers through the Smithsonian Transcription Center in DC. The transcription will allow the collection to be full-text searchable in ADS and for the notebooks to eventually be linked to their original source material: 500,000 glass plate photographs representing the first ever picture of the visible universe. The novel workflow of this distributed repository and the significance of the PHaEDRA collection both stand to support the research of future generations.

Research of radiation-resistant microbial organisms

Energy Technology Data Exchange (ETDEWEB)

Kim, Dongho; Lim, Sangyong; Joe, Minho; Park, Haejoon; Song, Hyunpa; Im, Seunghun; Kim, Haram; Kim, Whajung; Choi, Jinsu; Park, Jongchun

2012-01-15

Many extremophiles including radiation-resistant bacteria Deinococcus radiodurans have special characteristics such as novel enzymes and physiological active substances different from known biological materials and are being in the spotlight of biotechnology science. In this research, basic technologies for the production of new genetic resources and microbial strains by a series of studies in radiation-resistant microbial organisms were investigated and developed. Mechanisms required for radiation-resistant in Deinococcus radiodurans were partly defined by analyzing the function of dinB, pprI, recG, DRA{sub 0}279, pprM, and two-component signal transduction systems. To apply genetic resource and functional materials from Deinococcus species, omics analysis in response to cadmium, construction of macroscopic biosensor, and characterization of carotenoids and chaperon protein were performed. Additionally, potential use of D. geothermalis in monosaccharide production from non-biodegradable plant materials was evaluated. Novel radiation resistant yeasts and bacteria were isolated and identified from environmental samples to obtain microbial and genomic resources. An optimal radiation mutant breeding method was set up for efficient and rapid isolation of target microbial mutants. Furthermore, an efficient ethanol producing mutant strain with high production yield and productivity was constructed using the breeding method in collaboration with Korea Research Institute of Bioscience and Biotechnology. Three Deinococcal bioindicators for radiation dosage confirmation after radiation sterilization process were developed. These results provide a comprehensive information for novel functional genetic elements, enzymes, and physiological active substances production or application. Eventually, industrial microbial cell factories based on radiation resistant microbial genomes can be developed and the technologies can be diffused to bioindustry continuously by this project.

Research of radiation-resistant microbial organisms

International Nuclear Information System (INIS)

Kim, Dongho; Lim, Sangyong; Joe, Minho; Park, Haejoon; Song, Hyunpa; Im, Seunghun; Kim, Haram; Kim, Whajung; Choi, Jinsu; Park, Jongchun

2012-01-01

Many extremophiles including radiation-resistant bacteria Deinococcus radiodurans have special characteristics such as novel enzymes and physiological active substances different from known biological materials and are being in the spotlight of biotechnology science. In this research, basic technologies for the production of new genetic resources and microbial strains by a series of studies in radiation-resistant microbial organisms were investigated and developed. Mechanisms required for radiation-resistant in Deinococcus radiodurans were partly defined by analyzing the function of dinB, pprI, recG, DRA 0 279, pprM, and two-component signal transduction systems. To apply genetic resource and functional materials from Deinococcus species, omics analysis in response to cadmium, construction of macroscopic biosensor, and characterization of carotenoids and chaperon protein were performed. Additionally, potential use of D. geothermalis in monosaccharide production from non-biodegradable plant materials was evaluated. Novel radiation resistant yeasts and bacteria were isolated and identified from environmental samples to obtain microbial and genomic resources. An optimal radiation mutant breeding method was set up for efficient and rapid isolation of target microbial mutants. Furthermore, an efficient ethanol producing mutant strain with high production yield and productivity was constructed using the breeding method in collaboration with Korea Research Institute of Bioscience and Biotechnology. Three Deinococcal bioindicators for radiation dosage confirmation after radiation sterilization process were developed. These results provide a comprehensive information for novel functional genetic elements, enzymes, and physiological active substances production or application. Eventually, industrial microbial cell factories based on radiation resistant microbial genomes can be developed and the technologies can be diffused to bioindustry continuously by this project

Situation in France: Ethical Reflection on Research in Nanoscience and Nanotechnology

Science.gov (United States)

Bordé, Jacques

By the end of the 1990s, the possible impacts of nanotechnologies on humans and the environment had already come under the spotlight. Owing to the tremendous promise of the development programmes for these technologies, it seemed important to reflect upon a responsible way of implementing them. Even in 1989, as part of the MIT course on Law, Technology and Public Policy, David Forrest spoke in particular on the subject of regulating nanotechnology development, and in February 1999 a seminar was organised in California to devise guidelines on how to control the new risks associated with these recent technological possibilities [1].

Rh Disease

Science.gov (United States)

... Order bereavement materials News Moms Need Blog News & Media News Videos Mission stories Ambassadors Spotlights Tools & Resources Frequently ... Order bereavement materials News Moms Need Blog Stories & Media News & Media News Videos Mission stories Ambassadors Spotlights Tools & ...

Multi-channel integrated circuits for the detection and measurement of ionizing radiation

International Nuclear Information System (INIS)

Engel, G.L.; Duggireddi, N.; Vangapally, V.; Elson, J.M.; Sobotka, L.G.; Charity, R.J.

2011-01-01

The Integrated Circuits (IC) Design Research Laboratory at Southern Illinois University Edwardsville (SIUE) has collaborated with the Nuclear Reactions Group at Washington University (WU) to develop a family of multi-channel integrated circuits. To date, the collaboration has successfully produced two micro-chips. The first was an analog shaped and peak sensing chip with on-board constant-fraction discriminators and sparsified readout. This chip is known as Heavy-Ion Nuclear Physics-16 Channel (HINP16C). The second chip, christened PSD8C, was designed to logically complement (in terms of detector types) the HINP16C chip. Pulse Shape Discrimination-8 Channel (PSD8C), featuring three settable charge integration windows per channel, performs pulse shape discrimination (PSD). This paper summarizes the design, capabilities, and features of the HINP16C and PSD8C ICs. It proceeds to discuss the modifications, made to the ICs and their associated systems, which have attempted to improve ease of use, increase performance, and extend capabilities. The paper concludes with a brief discussion of what may be the next chip (employing a multi-sampling scheme) to be added to our CMOS ASIC 'tool box' for radiation detection instrumentation.

Chest X-Ray

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Full Text Available ... Professions Site Index A-Z Spotlight June is Men's Health Month Recently posted: How to Obtain and ... Thank you for your time! Spotlight June is Men's Health Month Recently posted: How to Obtain and ...

Your Radiologist Explains Nuclear Medicine

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Full Text Available ... Professions Site Index A-Z Spotlight June is Men's Health Month Recently posted: How to Obtain and ... Thank you for your time! Spotlight June is Men's Health Month Recently posted: How to Obtain and ...

Your Radiologist Explains Magnetic Resonance Angiography (MRA)

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Full Text Available ... Professions Site Index A-Z Spotlight June is Men's Health Month Recently posted: How to Obtain and ... time and for your attention! Spotlight June is Men's Health Month Recently posted: How to Obtain and ...

Your Radiologist Explains Magnetic Resonance Angiography (MRA)

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Full Text Available ... Site Index A-Z Spotlight Recently posted: Pancreatic Cancer The Limitations of Online Dose Calculators Video: The ... and for your attention! Spotlight Recently posted: Pancreatic Cancer The Limitations of Online Dose Calculators Video: The ...

When Should I Trust My Gut? Linking Domain Expertise to Intuitive Decision-Making Effectiveness

Science.gov (United States)

Dane, Erik; Rockmann, Kevin W.; Pratt, Michael G.

2012-01-01

Despite a growing body of scholarship on the concept of intuition, there is a scarcity of empirical research spotlighting the circumstances in which intuitive decision making is effective relative to analytical decision making. Seeking to address this deficiency, we conducted two laboratory studies assessing the link between domain expertise (low…

Exposure to scenic lighting devices: risk to the health of entertainment professionals

International Nuclear Information System (INIS)

Salsi, S.; Barlier-Salsi, A.

2013-01-01

The European directive 2006/25/EC on minimum health and safety requirements regarding the exposure of workers to the risks arising from optical radiation provides for risk assessment in workplaces. This is particularly important in entertainment, where intentional exposure to spotlights may be required for periods of 8 hours per working day. The aim of the study was to provide the lighting engineers with information, relative to the risks associated with spotlights, to help them to estimate the risks a priori of a lighting plan. This study consisted of determining the risks associated with 63 different spotlights, then distributing them into 4 groups of risks defined by the standard EN 62471, in calculating their permissible minimal exposure distance, corresponding to the use of 1 and 5 spotlights for a daily exposure time of 8 hours. This study highlighted that spotlights may cause health problems for entertainment workers. The classification proposed by the standard EN 62471 is not sufficient to estimate the risks of a lighting plan. Furthermore, the permissible minimal exposure distance and the permissible maximal exposure time do not constitute relevant parameters to reduce the risks to acceptable values. (authors)

Spotlight on Ethics: Institutional Review Boards as Systemic Bullies

Science.gov (United States)

Carr, Caleb T.

2015-01-01

Bullying, often considered an interpersonal or intergroup behaviour, has not been explored as an unintended artefact of organisational structure. Institutional review boards (IRBs), the 'human research ethics committees' at US universities, help oversee the protection of human research subjects, particularly in the social sciences within…

Spotlight on daytime napping during early childhood

OpenAIRE

Horváth,Klára; Plunkett,Kim

2018-01-01

Klára Horváth,1 Kim Plunkett2 12nd Department of Pediatrics, Semmelweis University, Budapest, Hungary; 2Department of Experimental Psychology, University of Oxford, Oxford, UK Abstract: Daytime napping undergoes a remarkable change in early childhood, and research regarding its relationship to cognitive development has recently accelerated. In this review, we summarize our current understanding of this relationship focusing on children aged <5 years. First, we eva...

Detergent-dependent separation of postsynaptic density, membrane rafts and other subsynaptic structures from the synaptic plasma membrane of rat forebrain.

Science.gov (United States)

Zhao, LiYing; Sakagami, Hiroyuki; Suzuki, Tatsuo

2014-10-01

We systematically investigated the purification process of post-synaptic density (PSD) and post-synaptic membrane rafts (PSRs) from the rat forebrain synaptic plasma membranes by examining the components and the structures of the materials obtained after the treatment of synaptic plasma membranes with TX-100, n-octyl β-d-glucoside (OG) or 3-([3-cholamidopropyl]dimethylammonio)-2-hydroxy-1-propanesulfonate (CHAPSO). These three detergents exhibited distinct separation profiles for the synaptic subdomains. Type I and type II PSD proteins displayed mutually exclusive distribution. After TX-100 treatment, type I PSD was recovered in two fractions: a pellet and an insoluble fraction 8, which contained partially broken PSD-PSR complexes. Conventional PSD was suggested to be a mixture of these two PSD pools and did not contain type II PSD. An association of type I PSD with PSRs was identified in the TX-100 treatment, and those with type II PSD in the OG and CHAPSO treatments. An association of GABA receptors with gephyrin was easily dissociated. OG at a high concentration solubilized the type I PSD proteins. CHAPSO treatment resulted in a variety of distinct fractions, which contained certain novel structures. Two different pools of GluA, either PSD or possibly raft-associated, were identified in the OG and CHAPSO treatments. These results are useful in advancing our understanding of the structural organization of synapses at the molecular level. We systematically investigated the purification process of post-synaptic density (PSD) and synaptic membrane rafts by examining the structures obtained after treatment of the SPMs with TX-100, n-octyl β-d-glucoside or CHAPSO. Differential distribution of type I and type II PSD, synaptic membrane rafts, and other novel subdomains in the SPM give clues to understand the structural organization of synapses at the molecular level. © 2014 International Society for Neurochemistry.

Fungible Correlation Matrices: A Method for Generating Nonsingular, Singular, and Improper Correlation Matrices for Monte Carlo Research.

Science.gov (United States)

Waller, Niels G

2016-01-01

For a fixed set of standardized regression coefficients and a fixed coefficient of determination (R-squared), an infinite number of predictor correlation matrices will satisfy the implied quadratic form. I call such matrices fungible correlation matrices. In this article, I describe an algorithm for generating positive definite (PD), positive semidefinite (PSD), or indefinite (ID) fungible correlation matrices that have a random or fixed smallest eigenvalue. The underlying equations of this algorithm are reviewed from both algebraic and geometric perspectives. Two simulation studies illustrate that fungible correlation matrices can be profitably used in Monte Carlo research. The first study uses PD fungible correlation matrices to compare penalized regression algorithms. The second study uses ID fungible correlation matrices to compare matrix-smoothing algorithms. R code for generating fungible correlation matrices is presented in the supplemental materials.

Oxidative damage and aging: spotlight on mitochondria.

Science.gov (United States)

Linford, Nancy J; Schriner, Samuel E; Rabinovitch, Peter S

2006-03-01

Whereas free radical damage has been proposed as a key component in the tissue degeneration associated with aging, there has been little evidence that free radical damage limits life span in mammals. The current research shows that overexpression of the antioxidant enzyme catalase in mitochondria can extend mouse life span. These results highlight the importance of mitochondrial damage in aging and suggest that when targeted appropriately, boosting antioxidant defenses can increase mammalian life span.

Assessment of peak skin dose in interventional cardiology: A comparison between Gafchromic film and dosimetric software em.dose.

Science.gov (United States)

Greffier, J; Van Ngoc Ty, C; Bonniaud, G; Moliner, G; Ledermann, B; Schmutz, L; Cornillet, L; Cayla, G; Beregi, J P; Pereira, F

2017-06-01

To compare the use of a dose mapping software to Gafchromic film measurement for a simplified peak skin dose (PSD) estimation in interventional cardiology procedure. The study was conducted on a total of 40 cardiac procedures (20 complex coronary angioplasty of chronic total occlusion (CTO) and 20 coronary angiography and coronary angioplasty (CA-PTCA)) conducted between January 2014 to December 2015. PSD measurement (PSD Film ) was obtained by placing XR-RV3 Gafchromic under the patient's back for each procedure. PSD (PSD em.dose ) was computed with the software em.dose©. The calculation was performed on the dose metrics collected from the private dose report of each procedure. Two calculation methods (method A: fluoroscopic kerma equally spread on cine acquisition and B: fluoroscopic kerma is added to one air Kerma cine acquisition that contributes to the PSD) were used to calculate the fluoroscopic dose contribution as fluoroscopic data were not recorded in our interventional room. Statistical analyses were carried out to compare PSD Film and PSD em.dose . The PSD Film median (1st quartile; 3rd quartile) was 0.251(0.190;0.336)Gy for CA-PTCA and 1.453(0.767;2.011)Gy for CTO. For method-A, the PSD em.dose was 0.248(0.182;0.369)Gy for CA-PTCA and 1.601(0.892;2.178)Gy for CTO, and 0.267(0.223;0.446)Gy and 1.75 (0.912;2.584)Gy for method-B, respectively. For the two methods, the correlation between PSD Film and PSD em.dose was strong. For all cardiology procedures investigated, the mean deviation between PSD Film and PSD em.dose was 3.4±21.1% for method-A and 17.3%±23.9% for method-B. The dose mapping software is convenient to calculate peak skin dose in interventional cardiology. Copyright © 2017 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.

SU-C-304-03: Experimental Investigation On the Accuracy of Plastic Scintillation Dosimeters in Small Fields

Energy Technology Data Exchange (ETDEWEB)

Papaconstadopoulos, P [McGill Montreal General Hospital, Montreal, QC (Canada); Archambault, L [CHUQ Pavillon Hotel-Dieu de Quebec, Quebec, QC (Canada); Seuntjens, J [McGill University, Montreal, Quebec (Canada)

2015-06-15

Purpose: To investigate the accuracy of the Exradin W1 (SI) and of an “in-house” plastic scintillation dosimeter (CHUQ PSD) in small radiation fields. Methods: Output factor (OF) measurements with the W1 and CHUQ PSD were performed for field sizes of 0.5 x 0.5, 1 x 1 and 2 x 2 cm{sup 2}. Both detectors were placed parallel to the central axis (CAX) in water. The spectrum discrimination calibration method was performed in each set-up to account for the Cerenkov (CRV) signal created in the fiber. The OFs were compared to the expected field factors in water derived using i) Monte Carlo (MC) simulations of an accurate accelerator model and ii) microLion (PTW) and D1V diode (SI) OFs. MC-derived correction factors were applied to both the microLion and D1V OFs. For the CHUQ PSD the calibration was repeated in water (// CAX), solid water (perpendicular to CAX) and under a shielded configuration. The signal was collected using a spectrometer (wavelength range = 185–1100 nm). Spectral analysis was performed to evaluate potential changes of the spectral distributions under the various calibration set-up configurations. Results: The W1 OFs presented an over-response for the 0.5 x 0.5 cm{sup 2} in the range of 3 – 4.1% relative to the expected field factor. The CHUQ PSD presented an under-response in the range of 1.5 – 2.7%, without accounting for volume averaging. The CRV spectra under the various calibration procedures appeared similar to each other and only minor changes were observed to the respective OFs. Conclusion: The W1 and CHUQ PSD can be used in small fields down to a 1 x 1 cm{sup 2} field size. Discrepancies were encountered between the two detectors for the smallest field size of 0.5 x 0.5 cm{sup 2} with the CHUQ PSD exhibiting a closer agreement to the expected field factor. Funding sources: 1) Alexander S. Onassis Public Benefit Foundation in Greece and 2) CREATE Medical Physics Research Training Network grant of the Natural Sciences and Engineering

Nutrition Frontiers - Spring 2018 | Division of Cancer Prevention

Science.gov (United States)

Dear Colleague, The spring issue of Nutrition Frontiers showcases the association of gut microbial communities in premenopausal women, how high-fat, high-calorie-diet-induced obesity may increase pancreatic cancer, and the effects of calorie restriction protocols on pro-inflammatory cytokines. Meet our spotlight investigator, Dr. Purnima Kumar, and her research on black

Nutrition Frontiers - Winter 2018 | Division of Cancer Prevention

Science.gov (United States)

Dear Colleague, The winter issue of Nutrition Frontiers showcases the chemopreventive activity of sulforaphane, how a high fat, high cholesterol diet may impact hepatocellular carcinoma, and p53 activation from benzyl isothiocyanate. Meet our spotlight investigator, Dr. John Groopman, and his research on detoxication of air pollutants with a broccoli supplement. Learn about

What Are College Students' Perceptions about Campus Safety?

Science.gov (United States)

Chekwa, Charles; Thomas, Eugene, Jr.; Jones, Valerie James

2013-01-01

Crime and violence on college and university campuses have found their way into the media spotlight. As a result, criminal and violent acts have become issues that warrant research. We discuss literature focused on the potential contributing factors that may lead to violent behavior. Additionally, we review legislation intended to protect students…

Development of Software to Model AXAF-I Image Quality

Science.gov (United States)

Geary, Joseph; Hawkins, Lamar; Ahmad, Anees; Gong, Qian

1997-01-01

This report describes work conducted on Delivery Order 181 between October 1996 through June 1997. During this period software was written to: compute axial PSD's from RDOS AXAF-I mirror surface maps; plot axial surface errors and compute PSD's from HDOS "Big 8" axial scans; plot PSD's from FITS format PSD files; plot band-limited RMS vs axial and azimuthal position for multiple PSD files; combine and organize PSD's from multiple mirror surface measurements formatted as input to GRAZTRACE; modify GRAZTRACE to read FITS formatted PSD files; evaluate AXAF-I test results; improve and expand the capabilities of the GT x-ray mirror analysis package. During this period work began on a more user-friendly manual for the GT program, and improvements were made to the on-line help manual.

Spotlight on daytime napping during early childhood.

Science.gov (United States)

Horváth, Klára; Plunkett, Kim

2018-01-01

Daytime napping undergoes a remarkable change in early childhood, and research regarding its relationship to cognitive development has recently accelerated. In this review, we summarize our current understanding of this relationship focusing on children aged napping status of children may modulate the relationship between learning and napping. Third, the possible role of sleep spindles, ie, specific electroencephalographic components during sleep, in cognitive development is explored. We conclude that daytime napping is crucial in early memory development.

Response characteristics of soil fractal features to different land uses in typical purple soil watershed.

Directory of Open Access Journals (Sweden)

Bang-lin Luo

Full Text Available As a fundamental characteristic of soil physical properties, the soil Particle Size Distribution (PSD is important in the research on soil moisture migration, solution transformation, and soil erosion. In this research, the PSD characteristics with distinct methods in different land uses are analyzed. The results show that the upper bound of the volume domain of the clay domain ranges from 5.743 μm to 5.749 μm for all land-use types. For the silt domain of purple soil, the value ranges among 286.852~286.966 μm. For all purple soil land-use types, the order of the volume domain fractal dimensions is D clayD silt(U>D sand (U>D sand and D silt>D silt(U>D sand>D sand(U, respectively. As it is compared with all Dvi, the D silt has the most significant correlativity to the soil texture and organic matter in different land uses of the typical purple soil watersheds. Therefore, Dsilt will be a potential indictor for evaluating the proportion of fine particles in the PSD, as well as a key measurement in soil quality and productivity studies.

Effects of different periods of paradoxical sleep deprivation and sleep recovery on lipid and glucose metabolism and appetite hormones in rats.

Science.gov (United States)

Brianza-Padilla, Malinalli; Bonilla-Jaime, Herlinda; Almanza-Pérez, Julio César; López-López, Ana Laura; Sánchez-Muñoz, Fausto; Vázquez-Palacios, Gonzalo

2016-03-01

Sleep has a fundamental role in the regulation of energy balance, and it is an essential and natural process whose precise impacts on health and disease have not yet been fully elucidated. The aim of this study was to assess the consequences of different periods of paradoxical sleep deprivation (PSD) and recovery from PSD on lipid profile, oral glucose tolerance test (OGTT) results, and changes in insulin, corticosterone, ghrelin, and leptin concentrations. Three-month-old male Wistar rats weighing 250-350 g were submitted to 24, 96, or 192 h of PSD or 192 h of PSD with 480 h of recovery. The PSD was induced by the multiple platforms method. Subsequently, the animals were submitted to an OGTT. One day later, the animals were killed and the levels of triglycerides, total cholesterol, lipoproteins (low-density lipoprotein, very-low-density lipoprotein, and high-density lipoprotein), insulin, ghrelin, leptin, and corticosterone in plasma were quantified. There was a progressive decrease in body weight with increasing duration of PSD. The PSD induced basal hypoglycemia over all time periods evaluated. Evaluation of areas under the curve revealed progressive hypoglycemia only after 96 and 192 h of PSD. There was an increase in corticosterone levels after 192 h of PSD. We conclude that PSD induces alterations in metabolism that are reversed after a recovery period of 20 days.

Grantee Spotlight: Bill Nelson, M.D., Ph.D.

Science.gov (United States)

Dr. William (Bill) Nelson is playing an integral role in advancing our understanding of cancer health disparities and helping to foster the interests of young students from underrepresented backgrounds in cancer/cancer health disparities research.

Nuclear Power : The roles, functions and opportunities for research institutes - An overview and recommendations

International Nuclear Information System (INIS)

Sheriffah Noor Khamseah Al-Idid Syed Ahmad Idid

2010-01-01

Shifting nuclear power from being the Last Option to a new energy mix for Malaysia has significant implications and requires specific actions, responses and support from critical stake holders including Government, Utility, Education Sectors and Research Institutes. This paper aims to briefly outline the roles and functions of these stake holders, but spotlighting on that of research institute. Presently the role of research and development (R and D) within a nuclear power programme is a controversial subject. Opinions range from assigning a continuing priority role in this area, to considering it a somewhat questionable effort at the present state of development of proven reactor types, in particular for countries which have not yet started or are at the earlier stages of the nuclear power programmes. As such Nuclear Malaysia may be facing a similar challenge in its quest to identify the most effective role and function for the agency to undertake for the 1st NPP. Thus it is within this context that his paper aims offer an overview of the activities and work scope required to support a Nuclear Power Programme (NPP) with the view that this will enable management and the scientific and research community to formulate strategies and work plan, in particular in terms of HRD and R and D plans, to further enhance its readiness to support Malaysia's first Nuclear Power programme, earmarked by the Government for the year 2020. Additionally it is hoped that this would contribute to the identification of an effective role, function and opportunities for Nuclear Malaysia in supporting Malaysia's first NPP. (author)

Spotlight: Ecuador.

Science.gov (United States)

1998-04-01

This article describes the vital statistics and population growth in Ecuador as of mid-1997. Mid-1997 population numbered about 12 million. Fertility was 3.6 births/woman; deaths were 6/1000 population; and births were 29/1000 population. Ecuador was primarily an agricultural country, until oil was discovered in the early 1970s. The country has worked to increase per capita income and confront environmental consequences. The capital city of Quito is situated in a valley between two mountains and has very high air pollution levels due to cars and factories. In contrast, indigenous populations live in the Andean mountains and farm small plots. Land shortages have pushed these farmers onto higher slopes and more marginal land that is becoming eroded. 22% of Ecuador's forests were cleared for farming during 1980-90. The city of Guayaquil, on the Pacific coast, has serious water pollution problems, sewage problems, and industrial pollution. Shrimp farming relies on high levels of fertilizer, which is damaging coastlines. Oil exploration in the interior of Ecuador, has resulted in disruption of indigenous population, loss of forests, and pollution of rivers. Texaco Oil is accused of spilling about 17 million gallons of crude oil, or 50 times more than the Exxon Valdez oil spill in Alaska. Texaco argues that it met government environmental standards and agreed to a cleanup, which only partially meets the standards of its critics. Oil resources have funded improvements in education and health. About 90% of Ecuador's adult population is literate. Fertility has declined, but the population is still largely young and will be entering their reproductive years by 2025.

Pakistan. Spotlight.

Science.gov (United States)

Greene, M

1985-01-01

Focus in this discussion of Pakistan is on demographic factors, the issue of ethnic versus national solidarity, and economic and social development. The population was estimated at 99.2 million in 1985. The birthrate was 43/1000 in 1984 and the deaths were 15/1000. The infant mortality rate is 105 infant deaths/1000 live births, and life expectancy at birth is 51 years. In 1983 the gross national product per capita was US$390. The population of Pakistan is concentrated around Karachi on the Arabian Sea and in the crescent formed by Lahore, Rawalpindi, and Peshawar. Pakistan was a British colony, part of the Indian subcontinent until partition in 1947, when Britain gave Pakistan and India their freedom. Pakistan is not a theocracy, but the military government turns to traditional Islam for affirmation of its authority. Its martial law regime, established in 1977, is headed by President Ziaul Haq. The issue of ethnic versus national solidarity has been a problem since independence. Bengali-speaking East Pakistanis felt they did not have equal power in their country whose official language was Urdu and whose capital was in West Pakistan. East and West Pakistan ended up in armed conflict with the formation of Bangladesh in 1971 as the result. Regional and ethnic conflict is exacerbated by the low rate of literacy and the low status of certain ethnic groups in Pakistan. In addition, Pakistan suffers problems typical of many developing nations: a low per capita income, a large and growing population, and a highly stratified traditional society. In 1981 doctors, engineers, and craftsmen were in short supply, but there was a surplus of 300,000 agricultural workers. Agriculture makes up 30% of the GNP and employs 55% of the work force. In Pakistan's 6th Five Year Plan, initiated in July 1983, the government acknowledged for the 1st time the extremely poor conditions for women as indicated by literacy, health, and fertility. The total fertility rate is 6.4 average births/woman. Although the government is ostensibly trying to help women, funding for women's programs during the Five Year Plan was cut. Economic growth has been good in recent years, but agricultural growth is a result of increased acreage rather than yield per acre.

Spotlight: Peru.

Science.gov (United States)

Yacher, L

1985-09-01

This article highlights population statistics from Peru, the 3rd largest country in Latin America. The population in 1985 has been estimated at 19.7 million. In 1982, the birth rate was 35/1000 and the mortality rate was 10/1000. Infant mortality stood at 99/1000 live births and life expectancy at birth was 59 years. 41% of Peru's population is under 15 years of age, and only 4% is 65 years of age or older. The country's total fertility rate is 5.2 births/woman. Only 0.4% of the population is foreign born. Peru is highly urbanized, and 65% of the country's total population growth in 1981 occurred in its cities. 1 in 3 Peruvians resides in the capital city of Lima. The 2 largest racial groups are mestizos and whites (53%) and Indians (46%). 21% of the population is illiterate. 40.7% of the labor force is employed in agriculture; however, only 15% of the national income is derived from agriculture. The GNP per capita was US$1040 in 1983. The country's economy is in serious trouble at present, with an annual inflation rate of 250% and a foreign debt of US$13.5 billion.

Spotlight: Togo.

Science.gov (United States)

May, J F

1988-12-01

The Republic of Togo is a land of 21,622 square miles on the west coast of Africa, 8 degrees north of the equator. The country is divided between the Kabye people in the north (22%) and the Ewe people in the south (35%). The president, General Gnassingbe Eyadema, is a Kabye. The population of 3.3 million (1988) is growing at the rate of 3.3%/year, despite an infant mortality of 107 deaths/1000 live births and a life expectancy of only 54 years. The total fertility rate is 6.5 children/woman. The birth rate is 47 births/1000 population, and the death rate is 14/1000. Population growth, especially in the cities of Lome and Kara, where 1/4 of the population lives, is considered a major threat to development. A Demographic and Health Survey has been taken, and a Conference on Population and Development was held in Lome in 1987 to draft a national population policy statement. Family planning services need to be implemented to raise the contraceptive prevalence rate above its present 2%, and the population needs to be redistributed, but this requires investment of funds currently being used to service the foreign debt. The country's gross national product is only $300 per capita.

Spotlight: Azerbaijan.

Science.gov (United States)

1999-02-01

As of mid-1998, Azerbaijan had a population of 7.7 million people residing in a land area of 33,436 square miles. There were 17 births and 6 deaths per 1000 population, as well as 19 infant deaths for every 1000 live births, and a population growing in size at 1.1% annually. The average woman had 2.1 births during her reproductive lifetime and life expectancy was 67 years for men and 74 years for women. Azerbaijan is an oil-producing country, although the agricultural sector is responsible for 25% of gross domestic product and employs 31% of the work force. Despite its oil wealth and strong agricultural and mining sectors, Azerbaijan is struggling to improve its environmental conditions and support a large refugee population. The country's air, water, and soil are severely polluted. Air pollution stems from petrochemical plants, refineries, exhaust fumes, and the burning of untreated garbage; water pollution is the result of oil spills, leaky pipelines and tanks, runoff of fertilizers and pesticides, and improperly treated sewage; and land pollution is due to inadequate waste management. The high incidence of waterborne diseases, including cholera, in Azerbaijan is caused by the inadequate treatment of drinking water and sewage intrusion into leaky distribution pipes. Although over 90% of infants under age 1 year are immunized against diphtheria, whooping cough, tetanus, polio, and measles, babies in Azerbaijan are 3 times as likely to die before reaching age 1 year than are babies in the US. Azerbaijani children are 5 times more likely to die by age 5 than are US children. Living conditions are especially difficult for the 12% of the overall population which are refugees.

Iran: spotlight.

Science.gov (United States)

Roudi, N

1987-09-01

Given its location between Asia and Asia Minor, Iran has been a country of strategic political importance throughout history. More than 98% of Iran's population is Moslem. During the early 20th century, as Iran gradually gained independence from the USSR and Turkey, a modernization process was begun. However, this modernization process was forced to yield to Islamic traditionalism after the 1979 Islamic Revolution. Women have been most affected by this change. The implementation of Islamic traditions has meant low job opportunity or motivation for continuing education among women. Although fertility remains high, the present government is satisfied with the current rate of population growth. Family planning is allowed if implemented within the framework of Islamic law, but abortion is illegal. Mortality fell substantially after World War II, but has not continued to decline. At present, both males and females have the same life expectancy at birth. Iran's population is growing at a rate of 4%/year, and can be expected to double in another 21 years. It has been projected that Iran, currently the 21st largest country in the world with a population of 50 million, will become the 15th largest with a population of 97 million by the year 2025. Tehran, the 20th largest city in 1985, is projected to be the 9th largest by the year 2000, with a population of 13.6 million.

Spotlight: Malaysia.

Science.gov (United States)

Patriquin, W

1988-03-01

Focus is on Malaysia -- its population and land area, its total fertility rate and mortality rate, economic development, contraceptive usage, and population policy. In 1987 Malaysia's population was estimated to be 16.1 million with births 31/1000 population and deaths 7/1000 population. The rate of natural increase is 2.4%, the total fertility rate 3.9 children/woman, and the infant mortality rate 30/1000 live births. Ethnically, Malaysia is made up of several distinct groups. Indigenous Malays are the most numerous -- about 50% of the population. Their unique characteristics include that they are Moslem, rural, and usually of lower economic status. Chinese make up the 2nd largest group of Malaysians, nearly 1/3 of the population. This group is active in trade, business, and finance and possesses considerable economic power. About 10% of the population is of Indian descent. Malaysia has experienced much economic growth. Traditional exports grew in volume and value during the 1970; the petroleum sector expanded so rapidly it accounts for 1/4 of all exports. One reason for Malaysia's rapid economic growth is the government's promotion of industrialization and foreign investment. According to the 1982 contraceptive prevalence survey, 42% of currently married women 15-44 years were using contraception. The government considers the current rate of national increase to be satisfactory, but in 1984 it adopted a population policy to more than quadruple its population in 2100 to 70 million. It intends to accomplish this by instituting pronatalist incentives to help the fall in the national growth rate. The government's rationale for more population growth is that a larger domestic population could better support industrial growth that otherwise might be stymied by "protectionist policies practiced by developed countries." Incentives to encourage fertility include income-tax deductions and maternity benefits for women who have up to 5 children.

Spotlight: Bangladesh.

Science.gov (United States)

Parikh, L

1998-01-01

This brief article highlights the progress made in Bangladesh in reducing fertility and improving women's status. The mid-1997 population was an estimated 122.2 million persons. The land area is 50,260 square miles. Population density was 2432 people per square mile. Births were 31 per 1000 persons. Deaths were 11 per 1000 persons. Infant deaths were 77 per 1000 live births. Natural increase was 2% per year. The total fertility rate was 3.3 births per woman. Life expectancy was 58 years for males and females. Bangladesh is one of the most densely populated countries in the world and has about 50% of US population situated on land the size of Wisconsin. Average annual income is about $240. Livelihoods from agriculture are affected by monsoons and natural disasters. Bangladesh has reduced its fertility by half since the mid-1970s. Almost 50% of married women relied on contraception during 1996-97, compared to only 8% of married women in 1975. Increases in contraceptive prevalence are attributed to the family planning program and parents' desire for smaller families. The government has made slowing population growth a priority since the 1970s. The 35,000 field workers provide door-to-door contraception and counseling. Mass media has promoted messages about the economic and health advantages of limiting or spacing births. Women continue to play a subordinate role to men, despite their improved control over fertility. Under 30% of women are literate compared to 50% of men. Islamic practices still confine women to the home. Programs are directed to improving women's financial status through credit programs. Women now hold many jobs in the new garment industry, which is the largest nonagricultural employer.

Risk Factors for Post-stroke Depression: A Meta-analysis

Directory of Open Access Journals (Sweden)

Yu Shi

2017-07-01

Full Text Available Background: Stroke not only impacts patients physically but also economically. Post-stroke depression (PSD, as a common complication of stroke, always obstructs the process of stroke rehabilitation. Accordingly, defining the risk factors associated with PSD has extraordinary importance. Although there have been many studies investigating the risk factors for PSD, the results are inconsistent.Objectives: The objectives of this study were to identify the risk factors for PSD by evidence-based medicine.Data sources: A systematic and comprehensive database search was performed of PubMed, Medline, CENTRAL, EMBASE.com, the Cochrane library and Web of Science for Literature, covering publications from January 1, 1998 to November 19, 2016.Study Selection: Studies on risk factors for PSD were identified, according to inclusion and exclusion criteria. The risk of bias tool, described in the Cochrane Handbook version 5.1.0, was used to assess the quality of each study. Meta-analysis was performed using RevMan 5.3 software.Results: Thirty-six studies were included for review. A history of mental illness was the highest ranking modifiable risk factor; other risk factors for PSD were female gender, age (<70 years, neuroticism, family history, severity of stroke, and level of handicap. Social support was a protective factor for PSD.Conclusion: There are many factors that have effects on PSD. The severity of stroke is an important factor in the occurrence of PSD. Mental history is a possible predictor of PSD. Prevention of PSD requires social and family participation.

The New Electron Microscopy: Cells and Molecules in Three Dimensions | Poster

Science.gov (United States)

NCI recently announced the launch of the new National Cryo-Electron Microscopy Facility (NCEF) at the Frederick National Laboratory for Cancer Research (FNLCR). The launch comes while cryo-electron microscopy (cryo-EM) is enjoying the spotlight as a newly emerging, rapidly evolving technology with the potential to revolutionize the field of structural biology. Read more...

Nutrition Frontiers - Winter 2017 | Division of Cancer Prevention

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Volume 8, Issue 1 Dear Colleague, The winter issue of Nutrition Frontiers showcases gut permeability and calcium supplementation, potential chemopreventive effects of dietary DHM for lung tumorigenesis, and the role of the MCP-1 chemokine on adiposity and inflammation. Learn about our spotlight investigator, Dr. Gregory Lesinski, and his research on dietary interventions to

Spotlight on acupuncture in laboratory animal medicine

Directory of Open Access Journals (Sweden)

Magden ER

2017-08-01

Full Text Available Elizabeth R Magden Department of Veterinary Sciences, Michale E Keeling Center for Comparative Medicine and Research, University of Texas MD Anderson Cancer Center, Bastrop, TX, USA Abstract: Acupuncture has been practiced for thousands of years, although it is only in the past century that science has worked to unravel the mechanisms behind its use. Literature supporting the efficacious use of acupuncture to treat a variety of conditions has been and continues to be published, including the randomized controlled studies we all appreciate when practicing evidence-based medicine. The use of acupuncture in veterinary medicine has paralleled the trends observed in people, with an increasingly common use to remedy specific medical conditions. These conditions are commonly related to neurological dysfunction or orthopedic pain. Although pain relief is the most common use of acupuncture, numerous other conditions have been shown to improve with this therapy. Laboratory animals are also benefiting from acupuncture. Its use is starting to be incorporated into research settings, although there is still further progress to be made in this field. Acupuncture has been shown to improve clinical conditions and quality of life in laboratory animals, and should be considered as a tool to treat laboratory animals with conditions known to benefit from therapy. Here we review the history, mechanisms of action, and use of acupuncture to treat veterinary patients and laboratory animals. Keywords: acupuncture, laboratory animals, nonhuman primates

Power Spectral Density Specification and Analysis of Large Optical Surfaces

Science.gov (United States)

Sidick, Erkin

2009-01-01

The 2-dimensional Power Spectral Density (PSD) can be used to characterize the mid- and the high-spatial frequency components of the surface height errors of an optical surface. We found it necessary to have a complete, easy-to-use approach for specifying and evaluating the PSD characteristics of large optical surfaces, an approach that allows one to specify the surface quality of a large optical surface based on simulated results using a PSD function and to evaluate the measured surface profile data of the same optic in comparison with those predicted by the simulations during the specification-derivation process. This paper provides a complete mathematical description of PSD error, and proposes a new approach in which a 2-dimentional (2D) PSD is converted into a 1-dimentional (1D) one by azimuthally averaging the 2D-PSD. The 1D-PSD calculated this way has the same unit and the same profile as the original PSD function, thus allows one to compare the two with each other directly.

Synaptic Interactome Mining Reveals p140Cap as a New Hub for PSD Proteins Involved in Psychiatric and Neurological Disorders

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Annalisa Alfieri

2017-06-01

Full Text Available Altered synaptic function has been associated with neurological and psychiatric conditions including intellectual disability, schizophrenia and autism spectrum disorder (ASD. Amongst the recently discovered synaptic proteins is p140Cap, an adaptor that localizes at dendritic spines and regulates their maturation and physiology. We recently showed that p140Cap knockout mice have cognitive deficits, impaired long-term potentiation (LTP and long-term depression (LTD, and immature, filopodia-like dendritic spines. Only a few p140Cap interacting proteins have been identified in the brain and the molecular complexes and pathways underlying p140Cap synaptic function are largely unknown. Here, we isolated and characterized the p140Cap synaptic interactome by co-immunoprecipitation from crude mouse synaptosomes, followed by mass spectrometry-based proteomics. We identified 351 p140Cap interactors and found that they cluster to sub complexes mostly located in the postsynaptic density (PSD. p140Cap interactors converge on key synaptic processes, including transmission across chemical synapses, actin cytoskeleton remodeling and cell-cell junction organization. Gene co-expression data further support convergent functions: the p140Cap interactors are tightly co-expressed with each other and with p140Cap. Importantly, the p140Cap interactome and its co-expression network show strong enrichment in genes associated with schizophrenia, autism, bipolar disorder, intellectual disability and epilepsy, supporting synaptic dysfunction as a shared biological feature in brain diseases. Overall, our data provide novel insights into the molecular organization of the synapse and indicate that p140Cap acts as a hub for postsynaptic complexes relevant to psychiatric and neurological disorders.

Environmental justice research shows the importance of social feedbacks in ecosystem service trade-offs

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Neil M. Dawson

2017-09-01

Full Text Available In this article, we shine a spotlight on approaches to research ecosystem service trade-offs and critically assess their representation of relevant social dynamics. Although studies linking ecosystem services and human well-being have provided theoretical insights into social and ecological trade-offs, we argue that ecosystem services research has paid insufficient attention to "social feedbacks," people's cognitive and behavioral responses to change. We demonstrate that augmenting ecosystem services research with environmental justice approaches (exploring perceptions of the distribution of costs and benefits, decision making procedures, and recognition of different values and identities can more effectively capture important responses to ecosystem governance. Spatial analysis of land use change, mixed-method assessment of multidimensional well-being, and qualitative environmental justice research were applied in three villages adjacent to Nam Et-Phou Louey National Protected Area in northern Laos. Spatial analysis showed that, from 2006 to 2015, forest clearance for cultivation remained stable within the protected area. Well-being assessment revealed the local population benefited from rapidly increasing incomes, asset ownership, and reduced poverty during that time. In combination, spatial and well-being analyses paint a picture of limited trade-offs, despite growing incentives to exploit protected land and resources through cash crops and high-value forest products. In contrast, results from environmental justice research revealed profound trade-offs between conservation and local practices, and highlight governance deficiencies relating to procedure and recognition. Consequently, formal protected area rules were perceived to be illegitimate by many and actively undermined, for example through negotiated access with alternative authorities. We conclude that although well-being research provides an essential foundation to understand diverse

Contribution of the JRC Ispra to the intercomparison of analysis methods for seismically isolated nuclear structures

International Nuclear Information System (INIS)

Magonette, G.; Renda, V.

2002-01-01

Aim of the work done at JRC has been essentially to investigate the potentiality of the Pseudo-Dynamic (PsD) method to test structures incorporating anti-seismic protection devices based on materials with a strain-rate dependent behaviour. This is of relevant importance due to the interest to perform tests on large-scale mock-ups to assess the behaviour of realistic structure of civil engineering interest. Two specific typologies of protection have been analysed and tested at the European Laboratory for Structural Assessment (ELSA) of JRC Ispra. The first dealing with base isolation and the second with energy dissipation devices. In both cases the protection devices were based on high damping rubber material which is characterised by a moderate dependence from the strain rate of the application of the displacements. To validate a standard procedure to test base isolated structures by the PsD method, a collaboration was set up with the Italian Working Group on Seismic Isolation which includes the national research centre ENEA, the national electricity board ENEL, the industrial research centre ISMES and a manufacturer of isolators ALGA. In the framework of this collaboration it was decided to test at the ELSA laboratory a scaled 5-storey frame structure (provided by ENEL), isolated by means of high damping rubber bearings (HDRBs), which had been tested on the shaking table of ISMES. This experimental activity aimed to compare the results which can be obtained by means of the PsD testing technique with those which can be obtained by means of a truly-dynamic test on a shaking table. To validate a standard procedure to test structures incorporating energy dissipation devices, an international collaboration has been set up with Industries, Research Centres and Universities in the framework of a project partially funded by the European Commission through the General Directorate for Science and Technology. The obtained results show once more that the PsD method, when

Taking flight with sensing equipment will deliver benefits across MDOT : research spotlight.

Science.gov (United States)

2015-04-01

Recent strides in technology have opened the doors for using unmanned : aerial vehicles (UAVs, sometimes called drones) throughout MDOT. An : extensive study on the viability of UAVs instrumented with remote : sensors demonstrated a wide range of cos...

Lead Halide Perovskite Nanocrystals in the Research Spotlight: Stability and Defect Tolerance

Science.gov (United States)

2017-01-01

This Perspective outlines basic structural and optical properties of lead halide perovskite colloidal nanocrystals, highlighting differences and similarities between them and conventional II–VI and III–V semiconductor quantum dots. A detailed insight into two important issues inherent to lead halide perovskite nanocrystals then follows, namely, the advantages of defect tolerance and the necessity to improve their stability in environmental conditions. The defect tolerance of lead halide perovskites offers an impetus to search for similar attributes in other related heavy metal-free compounds. We discuss the origins of the significantly blue-shifted emission from CsPbBr3 nanocrystals and the synthetic strategies toward fabrication of stable perovskite nanocrystal materials with emission in the red and infrared parts of the optical spectrum, which are related to fabrication of mixed cation compounds guided by Goldschmidt tolerance factor considerations. We conclude with the view on perspectives of use of the colloidal perovskite nanocrystals for applications in backlighting of liquid-crystal TV displays. PMID:28920080

MAGUKs: multifaceted synaptic organizers.

Science.gov (United States)

Won, Sehoon; Levy, Jon M; Nicoll, Roger A; Roche, Katherine W

2017-04-01

The PSD-95 family of proteins, known as MAGUKs, have long been recognized to be central building blocks of the PSD. They are categorized as scaffolding proteins, which link surface-expressed receptors to the intracellular signaling molecules. Although the four members of the PSD-95 family (PSD-95, PSD-93, SAP102, and SAP97) have many shared roles in regulating synaptic function, recent studies have begun to delineate specific binding partners and roles in plasticity. In the current review, we will highlight the conserved and unique roles of these proteins. Published by Elsevier Ltd.

Nutrition Frontiers - Summer 2016 | Division of Cancer Prevention

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Volume 7, Issue 3 The summer issue of Nutrition Frontiers showcases the combined effects of ursolic acid and resveratrol for skin cancer, the potential chemopreventive effects of the dietary supplement 4-MU, and a method to monitor a heterocyclic aromatic amine in dyed hair. Learn about our spotlight investigators, Drs. Michael Caligiuri and Jianhua Yu, and their research on

Nutrition Frontiers - Spring 2017 | Division of Cancer Prevention

Science.gov (United States)

Volume 8, Issue 2 Dear Colleague, The spring issue of Nutrition Frontiers showcases the calcium/magnesium intake ratio in colorectal adenoma, the role of PPARγ in metabolism and reproduction, and the effects of time-restricted feeding on metabolic parameters. Meet our spotlight investigator, Dr. Maria Cruz-Correa, and her research on gut bacterial genes, diet, and colorectal

Nutrition Frontiers - Spring 2016 | Division of Cancer Prevention

Science.gov (United States)

Volume 7, Issue 2 The spring issue of Nutrition Frontiers showcases green tea's effect on human metabolism, fish oil — as a chemopreventive agent in myeloid leukemia and, with pectin, how they affect microRNA expression in the colon. Learn about our spotlight investigator, Dr. Richard Eckert, and his research on skin cancer prevention, upcoming announcements and more. |

Deliberate Science, Continuum Magazine: Clean Energy Innovation at NREL, Winter 2012 (Book)

Energy Technology Data Exchange (ETDEWEB)

2012-02-01

This quarterly magazine is dedicated to stepping beyond the technical journals to reveal NREL's vital work in a real-world context for our stakeholders. Continuum provides insights into the latest and most impactful clean energy innovations, while spotlighting those talented researchers and unique facilities that make it all happen. This edition focuses on deliberate science.

New formulation for interferometric synthetic aperture radar for terrain mapping

Science.gov (United States)

Jakowatz, Charles V., Jr.; Wahl, Daniel E.; Eichel, Paul H.; Thompson, Paul A.

1994-06-01

The subject of interferometric synthetic aperture radar (IFSAR) for high-accuracy terrain elevation mapping continues to gain importance in the arena of radar signal processing. Applications to problems in precision terrain-aided guidance and automatic target recognition, as well as a variety of civil applications, are being studied by a number of researchers. Not unlike many other areas of SAR processing, the subject of IFSAR can, at first glance, appear to be somewhat mysterious. In this paper we show how the mathematics of IFSAR for terrain elevation mapping using a pair of spotlight mode SAR collections can be derived in a very straightforward manner. Here, we employ an approach that relies entirely on Fourier transforms, and utilizes no reference to range equations or Doppler concepts. The result is a simplified explanation of the fundamentals of interferometry, including an easily-seen link between image domain phase difference and terrain elevation height. The derivation builds upon previous work by the authors in which a framework for spotlight mode SAR image formation based on an analogy to 3D computerized axial tomography (CAT) was developed. After outlining the major steps in the mathematics, we show how a computer simulator which utilizes 3D Fourier transforms can be constructed that demonstrates all of the major aspects of IFSAR from spotlight mode collections.

Variation in Functional Independence among Stroke Survivors Having Fatigue and Depression.

Science.gov (United States)

Badaru, Umaru Muhammad; Ogwumike, Omoyemi Olubunmi; Adeniyi, Ade Fatai; Olowe, Olajide Olubanji

2013-01-01

Objective. This study evaluated variation in functional independence in activities of daily living (ADL) and instrumental activities of daily living (IADL) among individuals with poststroke fatigue (PSF) and poststroke depression (PSD). Methods. A cross-sectional survey involved 65 consenting poststroke survivors who were purposively recruited from physiotherapy clinics of the University College Hospital, Ibadan, Adeoyo Maternity Teaching Hospital, Ibadan, and Federal Medical Center, Gusau. Participants were assessed for symptoms of PSD with short geriatric depression scale-15, PSF with fatigue severity scale, ADL with Barthel Index and IADL with Nottingham extended ADL scale. Data analysis was done using Chi-square and unpaired t-test with significance level being 0.05. Results. Participants' age ranged from 58 to 80 years. PSD alone (P = 0.002) and both PSF and PSD (P = 0.02) were significantly associated with ADL, while PSF alone was not (P = 0.233). PSD alone (P = 0.001) and both PSF and PSD (P = 0.001) significantly negatively affected IADL, while PSF alone had no significant effect (P = 0.2). Conclusions. Participants with PSD alone and those with both PSF and PSD had lower functional independence in ADL and IADL.

Variation in Functional Independence among Stroke Survivors Having Fatigue and Depression

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Umaru Muhammad Badaru

2013-01-01

Full Text Available Objective. This study evaluated variation in functional independence in activities of daily living (ADL and instrumental activities of daily living (IADL among individuals with poststroke fatigue (PSF and poststroke depression (PSD. Methods. A cross-sectional survey involved 65 consenting poststroke survivors who were purposively recruited from physiotherapy clinics of the University College Hospital, Ibadan, Adeoyo Maternity Teaching Hospital, Ibadan, and Federal Medical Center, Gusau. Participants were assessed for symptoms of PSD with short geriatric depression scale-15, PSF with fatigue severity scale, ADL with Barthel Index and IADL with Nottingham extended ADL scale. Data analysis was done using Chi-square and unpaired t-test with significance level being 0.05. Results. Participants’ age ranged from 58 to 80 years. PSD alone (P=0.002 and both PSF and PSD (P=0.02 were significantly associated with ADL, while PSF alone was not (P=0.233. PSD alone (P=0.001 and both PSF and PSD (P=0.001 significantly negatively affected IADL, while PSF alone had no significant effect (P=0.2. Conclusions. Participants with PSD alone and those with both PSF and PSD had lower functional independence in ADL and IADL.

The influence of the fractal particle size distribution on the mobility of dry granular materials

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Vallejo Luis E.

2017-01-01

Full Text Available This study presents an experimental analysis on the influence of the particle size distribution (psd on the mobility of dry granular materials. The psd obeys a power law of the form: N(L>d=kd-Df, where N is the number of particles with diameter L greater than a given diameter d, k is a proportionality constant, and Df is the fractal dimension of the psd. No laboratory or numerical study has been conducted to date analysing how a fractal psd influences the mobility of granular flows as in the case of rock avalanches. In this study, the flow characteristics of poly-dispersed granular materials that have a fractal psd were investigated in the laboratory. Granular mixtures having different fractal psd values were placed in a hollow cylinder. The cylinder was lifted and the distance of flow of the mixture was measured with respect to the original position of the cylinder. It was determined that the distance of flow of the mixtures was directly related to their fractal psd values. That is, the larger the distance of flow of the mixture, the larger is the fractal psd of the granular mixture tested. Thus, the fractal psd in dry granular mixtures seems to have a large influence on the easiness by which dry granular mixtures move in the field.

Discriminating poststroke depression from stroke by nuclear magnetic resonance spectroscopy-based metabonomic analysis

Directory of Open Access Journals (Sweden)

Xiao J

2016-08-01

Full Text Available Jianqi Xiao,1,* Jie Zhang,2,* Dan Sun,3,* Lin Wang,4,* Lijun Yu,5 Hongjing Wu,5 Dan Wang,5 Xuerong Qiu5 1Department of Neurosurgery, The First Hospital of Qiqihar City, Qiqihar, 2Department of Internal Medicine, Central Hospital of Jiamusi City, Jiamusi, 3Department of Geriatrics, General Hospital of Daqing Oil Field, Daqing, 4Department of Nursing, 5Department of Neurology, The First Hospital of Qiqihar City, Qiqihar, Heilongjiang, People’s Republic of China *These authors contributed equally to this work Abstract: Poststroke depression (PSD, the most common psychiatric disease that stroke survivors face, is estimated to affect ~30% of poststroke patients. However, there are still no objective methods to diagnose PSD. In this study, to explore the differential metabolites in the urine of PSD subjects and to identify a potential biomarker panel for PSD diagnosis, the nuclear magnetic resonance-based metabonomic method was applied. Ten differential metabolites responsible for discriminating PSD subjects from healthy control (HC and stroke subjects were found, and five of these metabolites were identified as potential biomarkers (lactate, α-hydroxybutyrate, phenylalanine, formate, and arabinitol. The panel consisting of these five metabolites provided excellent performance in discriminating PSD subjects from HC and stroke subjects, achieving an area under the receiver operating characteristic curve of 0.946 in the training set (43 HC, 45 stroke, and 62 PSD subjects. Moreover, this panel could classify the blinded samples from the test set (31 HC, 33 stroke, and 32 PSD subjects with an area under the curve of 0.946. These results laid a foundation for the future development of urine-based objective methods for PSD diagnosis and investigation of PSD pathogenesis. Keywords: poststroke depression, PSD, stroke, nuclear magnetic resonance, NMR, metabonomic

WE-E-18A-03: How Accurately Can the Peak Skin Dose in Fluoroscopy Be Determined Using Indirect Dose Metrics?

International Nuclear Information System (INIS)

Jones, A; Pasciak, A

2014-01-01

Purpose: Skin dosimetry is important for fluoroscopically-guided interventions, as peak skin doses (PSD) that Result in skin reactions can be reached during these procedures. The purpose of this study was to assess the accuracy of different indirect dose estimates and to determine if PSD can be calculated within ±50% for embolization procedures. Methods: PSD were measured directly using radiochromic film for 41 consecutive embolization procedures. Indirect dose metrics from procedures were collected, including reference air kerma (RAK). Four different estimates of PSD were calculated and compared along with RAK to the measured PSD. The indirect estimates included a standard method, use of detailed information from the RDSR, and two simplified calculation methods. Indirect dosimetry was compared with direct measurements, including an analysis of uncertainty associated with film dosimetry. Factors affecting the accuracy of the indirect estimates were examined. Results: PSD calculated with the standard calculation method were within ±50% for all 41 procedures. This was also true for a simplified method using a single source-to-patient distance (SPD) for all calculations. RAK was within ±50% for all but one procedure. Cases for which RAK or calculated PSD exhibited large differences from the measured PSD were analyzed, and two causative factors were identified: ‘extreme’ SPD and large contributions to RAK from rotational angiography or runs acquired at large gantry angles. When calculated uncertainty limits [−12.8%, 10%] were applied to directly measured PSD, most indirect PSD estimates remained within ±50% of the measured PSD. Conclusions: Using indirect dose metrics, PSD can be determined within ±50% for embolization procedures, and usually to within ±35%. RAK can be used without modification to set notification limits and substantial radiation dose levels. These results can be extended to similar procedures, including vascular and interventional oncology

Overview of the OGAP Formative Assessment Project and CPRE's Large-Scale Experimental Study of Implementation and Impacts

Science.gov (United States)

Supovitz, Jonathan

2016-01-01

In this presentation discussed in this brief abstracted report, the author presents about an ongoing partnership with the Philadelphia School District (PSD) to implement and research the Ongoing Assessment Project (OGAP). OGAP is a systematic, intentional and iterative formative assessment system grounded in the research on how students learn…

Retrieval of Aerosol Microphysical Properties from AERONET Photo-Polarimetric Measurements. 2: A New Research Algorithm and Case Demonstration

Science.gov (United States)

Xu, Xiaoguang; Wang, Jun; Zeng, Jing; Spurr, Robert; Liu, Xiong; Dubovik, Oleg; Li, Li; Li, Zhengqiang; Mishchenko, Michael I.; Siniuk, Aliaksandr;

Inversion of particle size distribution by spectral extinction technique using the attractive and repulsive particle swarm optimization algorithm

Directory of Open Access Journals (Sweden)

Qi Hong

2015-01-01

Full Text Available The particle size distribution (PSD plays an important role in environmental pollution detection and human health protection, such as fog, haze and soot. In this study, the Attractive and Repulsive Particle Swarm Optimization (ARPSO algorithm and the basic PSO were applied to retrieve the PSD. The spectral extinction technique coupled with the Anomalous Diffraction Approximation (ADA and the Lambert-Beer Law were employed to investigate the retrieval of the PSD. Three commonly used monomodal PSDs, i.e. the Rosin-Rammer (R-R distribution, the normal (N-N distribution, the logarithmic normal (L-N distribution were studied in the dependent model. Then, an optimal wavelengths selection algorithm was proposed. To study the accuracy and robustness of the inverse results, some characteristic parameters were employed. The research revealed that the ARPSO showed more accurate and faster convergence rate than the basic PSO, even with random measurement error. Moreover, the investigation also demonstrated that the inverse results of four incident laser wavelengths showed more accurate and robust than those of two wavelengths. The research also found that if increasing the interval of the selected incident laser wavelengths, inverse results would show more accurate, even in the presence of random error.

Protection relay of phase-shifting device with thyristor switch for high voltage power transmission lines

Science.gov (United States)

Lachugin, V. F.; Panfilov, D. I.; Akhmetov, I. M.; Astashev, M. G.; Shevelev, A. V.

2014-12-01

Problems of functioning of differential current protection systems of phase shifting devices (PSD) with mechanically changed coefficient of transformation of shunt transformer are analyzed. Requirements for devices of protection of PSD with thyristor switch are formulated. Based on use of nonlinear models of series-wound and shunt transformers of PSD modes of operation of major protection during PSD, switching to zero load operation and to operation under load and during short circuit operation were studied for testing PSD with failures. Use of the principle of duplicating by devices of differential current protection (with realization of functions of breaking) of failures of separate pares of PSD with thyristor switch was substantiated. To ensure protection sensitivity to the shunt transformer winding short circuit, in particular, to a short circuit that is not implemented in the current differential protection for PSD with mechanical switch, the differential current protection reacting to the amount of primary ampere-turns of high-voltage and low-voltage winding of this transformer was designed. Studies have shown that the use of differential current cutoff instead of overcurrent protection for the shunt transformer wndings allows one to provide the sensitivity during thyristor failure with the formation of a short circuit. The results of simulation mode for the PSD with switch thyristor designed to be installed as switching point of Voskhod-Tatarskaya-Barabinsk 220 kV transmission line point out the efficiency of the developed solutions that ensure reliable functioning of the PSD.

Study on coordination of ventricular contraction by a phase analysis method in tetralogy of Fallot

International Nuclear Information System (INIS)

Chen Xianying; Zhu Hongyu; Li Xinmin; Wang Zhiguo; Zhang Guoxu; Zhang Zhaozhong; Wang Kaigeng

2001-01-01

Objective: Quantitative study on the characters of left ventricular (LV) wall motion and assessing degree of satisfaction of surgical repair of tetralogy of Fallot with phase standard deviation (PSD). Methods: PSD was calculated by equilibrium radionuclide ventriculography in 24 normal controls and 59 patients of tetralogy of Fallot before and after operation. Results: LV PSD was (9.7 +- 2.8) degree in 24 normal controls and (20.5 +- 15.5) degree and (10.0 +- 7.2) degree in 51(86.4%) of 59 patients of tetralogy of Fallot before and after surgical repair, respectively, and the difference was statistically significant (P < 0.01). LV PSD was (11.2 +- 7.8) degree and (21.3 +- 9.3) degree, respectively before and after surgical repair in the remaining 8(13.4%) patients and the LV PSD was increased significantly after operation (P < 0.05). Conclusions: LV PSD is coordinate with improving degree of ventricular wall motion and heart function after surgical repair of tetralogy of Fallot. PSD is one of the heart function parameters for reflecting the degree of satisfaction of the surgical repair

Spatial Identities at the Russo-Chinese Border: The Cases of Blagoveshensk and Heihe

Directory of Open Access Journals (Sweden)

M. I. Tislenko

2015-01-01

Full Text Available In this article the phenomenon of Blagoveshchensk and Heihe – border ‘twin cities’ – is in the spotlight of the researcher. The author observes, how these cities separated from each other by the Amur and the state border have been able to construct their own model of spatial identity taking into account Russian and Chinese national identities. 

Nutrition Frontiers - Summer 2017 | Division of Cancer Prevention

Science.gov (United States)

Volume 8, Issue 3 Dear Colleague, The summer issue of Nutrition Frontiers showcases insulin-like growth factor and vitamin D in prostate cancer risk, bile acid and FXR inactivation and gender dissimilarity, and CerS6, a novel transcriptional target of p53 protein. Meet our spotlight investigator, Dr. Wendy Russell, and her research on the functional role of the gut microbiota.

Utility-Scale Future, Continuum Magazine: Clean Energy Innovation at NREL, Spring 2011, Issue 1 Vol. 1

Energy Technology Data Exchange (ETDEWEB)

2011-08-01

This quarterly magazine is dedicated to stepping beyond the technical journals to reveal NREL's vital work in a real-world context for our stakeholders. Continuum provides insights into the latest and most impactful clean energy innovations, while spotlighting those talented researchers and unique facilities that make it all happen. This edition focuses on creating a utility-scale future.

NREL Spectrum of Clean Energy Innovation: Issue 3 (Book)

Energy Technology Data Exchange (ETDEWEB)

2012-11-01

This quarterly magazine is dedicated to stepping beyond the technical journals to reveal NREL's vital work in a real-world context for our stakeholders. Continuum provides insights into the latest and most impactful clean energy innovations, while spotlighting those talented researchers and unique facilities that make it all happen. This edition focuses on the NREL Spectrum of Clean Energy Innovation.

Development of active rear steer actuator. Development of four wheel steer actuator for active safety; Active rear steer actuator no kaihatsu. Yobo anzen ni muketa 4WS actuator no kaihatsu

Energy Technology Data Exchange (ETDEWEB)

Yamanaka, T [Aisin Seiki Co. Ltd., Aichi (Japan)

1997-10-01

Recently, ecology, energy saving and safety have become important issues. And Active Safety is spotlighted in vehicle control area. Many researches and developments on four wheel steer system have been done to improve vehicle stability. We have developed the Active Rear Steer system with electromechanical Actuator, which is mass-productive, compact, and high response and durable. 10 figs., 5 tabs.

[Changes in facial nerve function, morphology and neurotrophic factor III expression following three types of facial nerve injury].

Science.gov (United States)

Zhang, Lili; Wang, Haibo; Fan, Zhaomin; Han, Yuechen; Xu, Lei; Zhang, Haiyan

2011-01-01

To study the changes in facial nerve function, morphology and neurotrophic factor III (NT-3) expression following three types of facial nerve injury. Changes in facial nerve function (in terms of blink reflex (BF), vibrissae movement (VM) and position of nasal tip) were assessed in 45 rats in response to three types of facial nerve injury: partial section of the extratemporal segment (group one), partial section of the facial canal segment (group two) and complete transection of the facial canal segment lesion (group three). All facial nerves specimen were then cut into two parts at the site of the lesion after being taken from the lesion site on 1st, 7th, 21st post-surgery-days (PSD). Changes of morphology and NT-3 expression were evaluated using the improved trichrome stain and immunohistochemistry techniques ,respectively. Changes in facial nerve function: In group 1, all animals had no blink reflex (BF) and weak vibrissae movement (VM) at the 1st PSD; The blink reflex in 80% of the rats recovered partly and the vibrissae movement in 40% of the rats returned to normal at the 7th PSD; The facial nerve function in 600 of the rats was almost normal at the 21st PSD. In group 2, all left facial nerve paralyzed at the 1st PSD; The blink reflex partly recovered in 40% of the rats and the vibrissae movement was weak in 80% of the rats at the 7th PSD; 8000 of the rats'BF were almost normal and 40% of the rats' VM completely recovered at the 21st PSD. In group 3, The recovery couldn't happen at anytime. Changes in morphology: In group 1, the size of nerve fiber differed in facial canal segment and some of myelin sheath and axons degenerated at the 7th PSD; The fibres' degeneration turned into regeneration at the 21st PSD; In group 2, the morphologic changes in this group were familiar with the group 1 while the degenerated fibers were more and dispersed in transection at the 7th PSD; Regeneration of nerve fibers happened at the 21st PSD. In group 3, most of the fibers

How accurately can the peak skin dose in fluoroscopy be determined using indirect dose metrics?

International Nuclear Information System (INIS)

Jones, A. Kyle; Ensor, Joe E.; Pasciak, Alexander S.

2014-01-01

Purpose: Skin dosimetry is important for fluoroscopically-guided interventions, as peak skin doses (PSD) that result in skin reactions can be reached during these procedures. There is no consensus as to whether or not indirect skin dosimetry is sufficiently accurate for fluoroscopically-guided interventions. However, measuring PSD with film is difficult and the decision to do so must be madea priori. The purpose of this study was to assess the accuracy of different types of indirect dose estimates and to determine if PSD can be calculated within ±50% using indirect dose metrics for embolization procedures. Methods: PSD were measured directly using radiochromic film for 41 consecutive embolization procedures at two sites. Indirect dose metrics from the procedures were collected, including reference air kerma. Four different estimates of PSD were calculated from the indirect dose metrics and compared along with reference air kerma to the measured PSD for each case. The four indirect estimates included a standard calculation method, the use of detailed information from the radiation dose structured report, and two simplified calculation methods based on the standard method. Indirect dosimetry results were compared with direct measurements, including an analysis of uncertainty associated with film dosimetry. Factors affecting the accuracy of the different indirect estimates were examined. Results: When using the standard calculation method, calculated PSD were within ±35% for all 41 procedures studied. Calculated PSD were within ±50% for a simplified method using a single source-to-patient distance for all calculations. Reference air kerma was within ±50% for all but one procedure. Cases for which reference air kerma or calculated PSD exhibited large (±35%) differences from the measured PSD were analyzed, and two main causative factors were identified: unusually small or large source-to-patient distances and large contributions to reference air kerma from cone

2-Methyl-6-(phenylethynyl pyridine (MPEP reverses maze learning and PSD-95 deficits in Fmr1 knock-out mice.

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Réno Michelle Gandhi

2014-03-01

Full Text Available Fragile X syndrome (FXS is caused by the lack of expression of the fragile X mental retardation protein (FMRP, which results in intellectual disability and other debilitating symptoms including impairment of visual-spatial functioning. FXS is the only single-gene disorder that is highly co-morbid with autism spectrum disorder and can therefore provide insight into its pathophysiology. Lack of FMRP results in altered group I metabotropic glutamate receptor (mGluR signalling, which is a target for putative treatments. The Hebb-Williams (H-W mazes are a set of increasingly complex spatial navigation problems that depend on intact hippocampal and thus mGluR-5 functioning. In the present investigation, we examined whether an antagonist of mGluR-5 would reverse previously described behavioural deficits in Fmr1 KO mice. Mice were trained on a subset of the H-W mazes and then treated with either 20 mg/kg of an mGluR-5 antagonist, 2-Methyl-6-(phenylethynyl pyridine (MPEP; n = 11 or an equivalent dose of saline (n = 11 prior to running test mazes. Latency and errors were dependent variables recorded during the test phase. Immediately after completing each test, marble-burying behavior was assessed which confirmed that the drug treatment was pharmacologically active during maze learning. Although latency was not statistically different between the groups, MPEP treated Fmr1 KO mice made significantly fewer errors on mazes deemed more difficult suggesting a reversal of the behavioural deficit. MPEP treated mice were also less perseverative and impulsive when navigating mazes. Furthermore, MPEP treatment reversed PSD-95 protein deficits in Fmr1 KO treated mice, whereas levels of a control protein (β-tubulin remained unchanged. These data further validate MPEP as a potentially beneficial treatment for FXS. Our findings also suggest that adapted H-W mazes may be a useful tool to document alterations in behavioural functioning following pharmacological

The results of nocturnal visual surveys are influenced by lamp properties

Science.gov (United States)

Lardner, B.; Savidge, J.A.; Rodda, G.H.; Reed, R.N.; Adams, A.A.Y.

2009-01-01

We conducted standardized visual searches at night for brown treesnakes (Boiga irregularis) and geckos, where we alternated between spotlight and floodlight lamps. Floodlights rendered us 25% more snakes and 71% more geckos than did spotlights. We show data on searcher variability and discuss what might affect the relative benefit of different lamp types. ?? 2009 Brill Academic Publishers.

Agrobacterium tumefaciens-mediated transformation of the soybean pathogen Phomopsis longicolla

Science.gov (United States)

Phomopsis seed decay (PSD) of soybean is caused primarily by the fungal pathogen Phomopsis longicolla. PSD impairs seed germination, reduces seedling vigor, and can substantially reduce stand establishment. In hot and humid conditions, PSD can cause significant yield losses. Few studies have explore...

Distinct expression of synaptic NR2A and NR2B in the central nervous system and impaired morphine tolerance and physical dependence in mice deficient in postsynaptic density-93 protein

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Johns Roger A

2008-10-01

Full Text Available Abstract Postsynaptic density (PSD-93, a neuronal scaffolding protein, binds to and clusters N-methyl-D-aspartate receptor (NMDAR subunits NR2A and NR2B at cellular membranes in vitro. However, the roles of PSD-93 in synaptic NR2A and NR2B targeting in the central nervous system and NMDAR-dependent physiologic and pathologic processes are still unclear. We report here that PSD-93 deficiency significantly decreased the amount of NR2A and NR2B in the synaptosomal membrane fractions derived from spinal cord dorsal horn and forebrain cortex but did not change their levels in the total soluble fraction from either region. However, PSD-93 deficiency did not markedly change the amounts of NR2A and NR2B in either synaptosomal or total soluble fractions from cerebellum. In mice deficient in PSD-93, morphine dose-dependent curve failed to shift significantly rightward as it did in wild type (WT mice after acute and chronic morphine challenge. Unlike WT mice, PSD-93 knockout mice also showed marked losses of NMDAR-dependent morphine analgesic tolerance and associated abnormal sensitivity in response to mechanical, noxious thermal, and formalin-induced inflammatory stimuli after repeated morphine injection. In addition, PSD-93 knockout mice displayed dramatic loss of jumping activity, a typical NMDAR-mediated morphine withdrawal abstinence behavior. These findings indicate that impaired NMDAR-dependent neuronal plasticity following repeated morphine injection in PSD-93 knockout mice is attributed to PSD-93 deletion-induced alterations of synaptic NR2A and NR2B expression in dorsal horn and forebrain cortex neurons. The selective effect of PSD-93 deletion on synaptic NMDAR expression in these two major pain-related regions might provide the better strategies for the prevention and treatment of opioid tolerance and physical dependence.

The Role of the Two-Pore Domain Potassium Channel TREK-1 in the Therapeutic Effects of Escitalopram in a Rat Model of Poststroke Depression.

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Lin, Dai-Hua; Zhang, Xiang-Rong; Ye, Dong-Qing; Xi, Guang-Jun; Hui, Jiao-Jie; Liu, Shan-Shan; Li, Lin-Jiang; Zhang, Zhi-Jun

2015-06-01

Poststroke depression (PSD) is one of the most common neuropsychiatric complications after stroke. TREK-1, a two-pore-domain potassium channel, has been implicated in the pathogenesis of stroke and depression. The aim of this study was to investigate whether TREK-1 plays a role in the therapeutic effects of the selective serotonin reuptake inhibitor (SSRI) escitalopram in a rat PSD model. The whole-cell patch-clamp technique was performed to assess the effect of escitalopram on recombinant TREK-1 currents in HEK293 cells. The expression of TREK-1 mRNA and protein was measured in the hippocampus and prefrontal cortex (PFC), and neural stem cell (NSC) proliferation was detected in the hippocampal dentate gyrus (DG) in PSD rats after 3 weeks of escitalopram administration. Escitalopram reversibly inhibited TREK-1 currents in a concentration-dependent manner. Chronic treatment with escitalopram significantly reversed the reductions in weight gain, locomotor activity, and sucrose preference in PSD rats. The expressions of TREK-1 mRNA and protein were significantly increased in hippocampal CA1, CA3, DG, and PFC in PSD rats, with the exception of TREK-1 mRNA in hippocampal CA1. NSC proliferation was significantly decreased in hippocampal DG of PSD rats. Escitalopram significantly reversed the regional increases of TREK-1 expression and the reduction of hippocampal NSC proliferation in PSD rats. TREK-1 plays an important role in the therapeutic effects of the SSRI escitalopram in PSD model, making TREK-1 an attractive candidate molecule for further understanding the pathophysiology and treatment of PSD. © 2015 John Wiley & Sons Ltd.

Properties of pattern standard deviation in open-angle glaucoma patients with hemi-optic neuropathy and bi-optic neuropathy.

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Heo, Dong Won; Kim, Kyoung Nam; Lee, Min Woo; Lee, Sung Bok; Kim, Chang-Sik

2017-01-01

To evaluate the properties of pattern standard deviation (PSD) according to localization of the glaucomatous optic neuropathy. We enrolled 242 eyes of 242 patients with primary open-angle glaucoma, with a best-corrected visual acuity ≥ 20/25, and no media opacity. Patients were examined via dilated fundus photography, spectral-domain optical coherence tomography, and Humphrey visual field examination, and divided into those with hemi-optic neuropathy (superior or inferior) and bi-optic neuropathy (both superior and inferior). We assessed the relationship between mean deviation (MD) and PSD. Using broken stick regression analysis, the tipping point was identified, i.e., the point at which MD became significantly associated with a paradoxical reversal of PSD. In 91 patients with hemi-optic neuropathy, PSD showed a strong correlation with MD (r = -0.973, β = -0.965, p < 0.001). The difference between MD and PSD ("-MD-PSD") was constant (mean, -0.32 dB; 95% confidence interval, -2.48~1.84 dB) regardless of visual field defect severity. However, in 151 patients with bi-optic neuropathy, a negative correlation was evident between "-MD-PSD" and MD (r2 = 0.907, p < 0.001). Overall, the MD tipping point was -14.0 dB, which was close to approximately 50% damage of the entire visual field (p < 0.001). Although a false decrease of PSD usually begins at approximately 50% visual field damage, in patients with hemi-optic neuropathy, the PSD shows no paradoxical decrease and shows a linear correlation with MD.

Spotlight on daytime napping during early childhood

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Horváth K

2018-03-01

Full Text Available Klára Horváth,1 Kim Plunkett2 12nd Department of Pediatrics, Semmelweis University, Budapest, Hungary; 2Department of Experimental Psychology, University of Oxford, Oxford, UK Abstract: Daytime napping undergoes a remarkable change in early childhood, and research regarding its relationship to cognitive development has recently accelerated. In this review, we summarize our current understanding of this relationship focusing on children aged <5 years. First, we evaluate different studies on the basis of the experimental design used and the specific cognitive processes they investigate. Second, we analyze how the napping status of children may modulate the relationship between learning and napping. Third, the possible role of sleep spindles, ie, specific electroencephalographic components during sleep, in cognitive development is explored. We conclude that daytime napping is crucial in early memory development. Keywords: napping, children, infants, cognitive development, daytime sleep, memory, language development, sleep spindles

Statistical and Machine-Learning Classifier Framework to Improve Pulse Shape Discrimination System Design

Energy Technology Data Exchange (ETDEWEB)

Wurtz, R. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Kaplan, A. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

2015-10-28

Pulse shape discrimination (PSD) is a variety of statistical classifier. Fully-­realized statistical classifiers rely on a comprehensive set of tools for designing, building, and implementing. PSD advances rely on improvements to the implemented algorithm. PSD advances can be improved by using conventional statistical classifier or machine learning methods. This paper provides the reader with a glossary of classifier-­building elements and their functions in a fully-­designed and operational classifier framework that can be used to discover opportunities for improving PSD classifier projects. This paper recommends reporting the PSD classifier’s receiver operating characteristic (ROC) curve and its behavior at a gamma rejection rate (GRR) relevant for realistic applications.

Frequency-specific attentional modulation in human primary auditory cortex and midbrain.

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Riecke, Lars; Peters, Judith C; Valente, Giancarlo; Poser, Benedikt A; Kemper, Valentin G; Formisano, Elia; Sorger, Bettina

2018-07-01

Paying selective attention to an audio frequency selectively enhances activity within primary auditory cortex (PAC) at the tonotopic site (frequency channel) representing that frequency. Animal PAC neurons achieve this 'frequency-specific attentional spotlight' by adapting their frequency tuning, yet comparable evidence in humans is scarce. Moreover, whether the spotlight operates in human midbrain is unknown. To address these issues, we studied the spectral tuning of frequency channels in human PAC and inferior colliculus (IC), using 7-T functional magnetic resonance imaging (FMRI) and frequency mapping, while participants focused on different frequency-specific sounds. We found that shifts in frequency-specific attention alter the response gain, but not tuning profile, of PAC frequency channels. The gain modulation was strongest in low-frequency channels and varied near-monotonically across the tonotopic axis, giving rise to the attentional spotlight. We observed less prominent, non-tonotopic spatial patterns of attentional modulation in IC. These results indicate that the frequency-specific attentional spotlight in human PAC as measured with FMRI arises primarily from tonotopic gain modulation, rather than adapted frequency tuning. Moreover, frequency-specific attentional modulation of afferent sound processing in human IC seems to be considerably weaker, suggesting that the spotlight diminishes toward this lower-order processing stage. Our study sheds light on how the human auditory pathway adapts to the different demands of selective hearing. Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.

(Un)ethical behavior in organizations.

Science.gov (United States)

Treviño, Linda Klebe; den Nieuwenboer, Niki A; Kish-Gephart, Jennifer J

2014-01-01

This review spotlights research related to ethical and unethical behavior in organizations. It builds on previous reviews and meta-analyses of the literature on (un)ethical behavior in organizations and discusses recent advances in the field. The review emphasizes how this research speaks to the influence of the organizational context on (un)ethical behavior, proceeding from a more macro to a more micro view on (un)ethical behavior and covering ethical infrastructures, interpersonal influences, individual differences, and cognitive and affective processes. The conclusion highlights opportunities for future research.

Current development of UAV sense and avoid system

Science.gov (United States)

Zhahir, A.; Razali, A.; Mohd Ajir, M. R.

2016-10-01

As unmanned aerial vehicles (UAVs) are now gaining high interests from civil and commercialised market, the automatic sense and avoid (SAA) system is currently one of the essential features in research spotlight of UAV. Several sensor types employed in current SAA research and technology of sensor fusion that offers a great opportunity in improving detection and tracking system are presented here. The purpose of this paper is to provide an overview of SAA system development in general, as well as the current challenges facing UAV researchers and designers.

Results of measurements of particulate matter concentrations inside a pig fattening facility

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Ulens, T.

2016-01-01

Full Text Available Description of the subject. This research note discusses the results of measurements of particulate matter concentrations inside a pig fattening facility. Objectives. The objectives of the present study were to investigate the correlations between the different size fractions of indoor particulate matter (PM inside a pig fattening facility and to investigate the evolution of particle size distribution (PSD through a fattening period and between two housing systems and two cleaning protocols. Method. Data from two consecutive fattening periods in a commercial pig barn were used. Results. Very high correlations were found between PM10 and PM2.5 indoor concentrations. Depending on the measuring instrument, high or low correlations were found between PM1 and PM10 or PM2.5 indoor concentrations. No differences in PSD could be found between the two housing systems or the two cleaning protocols. Conclusions. The results from the present study showed high correlations between the indoor concentrations of PM10 and PM2.5. In the present study, no differences in PSD were found.

How does particle size influence caking in lactose powder?

DEFF Research Database (Denmark)

Carpin, Melanie Anne; Bertelsen, H.; Dalberg, A.

2017-01-01

Particle size distribution (PSD) is known to influence product properties such as flowability and compressibility. When producing crystalline lactose, different steps can affect the PSD of the final powder. The aim of this study was to investigate the influence of PSD on caking and the mechanisms...

Involvement of a putative substrate binding site in the biogenesis and assembly of phosphatidylserine decarboxylase 1 from Saccharomyces cerevisiae.

Science.gov (United States)

Di Bartolomeo, Francesca; Doan, Kim Nguyen; Athenstaedt, Karin; Becker, Thomas; Daum, Günther

2017-07-01

In the yeast Saccharomyces cerevisiae, the mitochondrial phosphatidylserine decarboxylase 1 (Psd1p) produces the largest amount of cellular phosphatidylethanolamine (PE). Psd1p is synthesized as a larger precursor on cytosolic ribosomes and then imported into mitochondria in a three-step processing event leading to the formation of an α-subunit and a β-subunit. The α-subunit harbors a highly conserved motif, which was proposed to be involved in phosphatidylserine (PS) binding. Here, we present a molecular analysis of this consensus motif for the function of Psd1p by using Psd1p variants bearing either deletions or point mutations in this region. Our data show that mutations in this motif affect processing and stability of Psd1p, and consequently the enzyme's activity. Thus, we conclude that this consensus motif is essential for structural integrity and processing of Psd1p. Copyright © 2017 Elsevier B.V. All rights reserved.

Influence of sampling properties of fast-waveform digitizers on neutron−gamma-ray, pulse-shape discrimination for organic scintillation detectors

International Nuclear Information System (INIS)

Flaska, Marek; Faisal, Muhammad; Wentzloff, David D.; Pozzi, Sara A.

2013-01-01

One of the most important questions to be answered with regard to digital pulse-shape discrimination (PSD) systems based on organic scintillators is: What sampling properties are required for a fast-waveform digitizer used for digitizing neutron/gamma-ray pulses, while an accurate PSD is desired? Answering this question is the main objective of this paper. Specifically, the paper describes the influence of the resolution and sampling frequency of a waveform digitizer on the PSD performance of organic scintillators. The results presented in this paper are meant to help the reader choosing a waveform digitizer with appropriate bit resolution and sampling frequency. The results presented here show that a 12-bit, 250-MHz digitizer is a good choice for applications that require good PSD performance. However, when more accurate PSD performance is the main requirement, this paper presents PSD figures of merit to qualify the impact of further increasing either sampling frequency or resolution of the digitizer

Professional nursing burnout and irrational thinking: a replication study.

Science.gov (United States)

Balevre, Park S; Cassells, Julie; Buzaianu, Elena

2012-01-01

This expanded (n = 648) replication study examines job-related burnout in practicing nurses in relation to five maladaptive thinking patterns at eight northeast Florida hospitals. Data supported the hypothesis that maladaptive thinking patterns may be related to nurses' burnout thoughts and behaviors. The focus of this research spotlights the individual nurse's thoughts, emotions, and actions and suggests that these burnout tendencies can be mitigated if not changed.

Power-spectral-density relationship for retarded differential equations

Science.gov (United States)

Barker, L. K.

1974-01-01

The power spectral density (PSD) relationship between input and output of a set of linear differential-difference equations of the retarded type with real constant coefficients and delays is discussed. The form of the PSD relationship is identical with that applicable to unretarded equations. Since the PSD relationship is useful if and only if the system described by the equations is stable, the stability must be determined before applying the PSD relationship. Since it is sometimes difficult to determine the stability of retarded equations, such equations are often approximated by simpler forms. It is pointed out that some common approximations can lead to erroneous conclusions regarding the stability of a system and, therefore, to the possibility of obtaining PSD results which are not valid.

Digital pulse shape discrimination

International Nuclear Information System (INIS)

Miller, L. F.; Preston, J.; Pozzi, S.; Flaska, M.; Neal, J.

2007-01-01

Pulse-shape discrimination (PSD) has been utilised for about 40 years as a method to obtain estimates for dose in mixed neutron and photon fields. Digitizers that operate close to GHz are currently available at a reasonable cost, and they can be used to directly sample signals from photomultiplier tubes. This permits one to perform digital PSD rather than the traditional, and well-established, analogous techniques. One issue that complicates PSD for neutrons in mixed fields is that the light output characteristics of typical scintillators available for PSD, such as BC501A, vary as a function of energy deposited in the detector. This behaviour is more easily accommodated with digital processing of signals than with analogous signal processing. Results illustrate the effectiveness of digital PSD. (authors)

Design and Experiment of a Differential-Based Power Split Device

Directory of Open Access Journals (Sweden)

Xiaohua Zeng

2014-04-01

Full Text Available Hybrid electric vehicles have excellent energy efficiency and emission performance. Power split device (PSD is a key component that directly affects the control strategy of power systems, the economic consumption of fuel, and the dynamic performance of vehicles. A differential-based PSD was proposed in this paper. A traditional differential was taken as the prototype and a new design method is proposed to retrofit the differential into a PSD. First, a comprehensive approach that includes theoretical analysis and software simulation was used to analyze the possibility as well as the necessity of retrofitting the differential into PSD. Then the differential was retrofitted. Finally, finite element analysis and bench test were conducted. Results showed that applying the retrofitted differential as PSD is practicable.

Peeling skin diseases: 21 cases from Turkey and a review of the literature.

Science.gov (United States)

Köse, O; Safali, M; Koç, E; Arca, E; Açikgöz, G; Özmen, I; Yeniay, Y

2012-07-01

Peeling skin diseases (PSD) refer to a group of rare autosomal recessive dermatosis which are characterized by spontaneous, continual peeling of the skin. Three different clinical pictures can be distinguished: Inflammatory PSD also referred to as peeling skin syndrome (PSS) type B, non-inflammatory PSD also referred to as PSS type A, and localized forms i.e. acral type PSS. To characterize the clinical and histopathological features of PSD in Turkey. We retrospectively reviewed the medical records and clinical photographs of patients who were given diagnosis of PSD and conducted histopathological evaluation of skin biopsies to identify the site of cleavage. Also we evaluated the cases including age, gender, age onset, clinical and histological findings, family history, associated disorders and PSD type. Twenty-one patients with PSD were seen at Gulhane School of Medicine in Ankara between the years 1994 and 2010 in this retrospective study. All patients were men. Their ages were between 20 and 26 years (22.44±2.30, Mean age±SD). Of the patients, eight cases (40%) were type A, eight cases (40%) were type B, and five cases (20%) were acral type PSS. Eleven cases (52%) had parental consanguinity. Keratoderma, cheilitis, keratosis pilaris, melanonichia, clubbing, hyperhidrosis, onychodystrophy were observed in eight cases as an accompanying disorder. In this case series, PSD occurred rarely and also showed generally mild course of disease in Turkey and most likely related to consanguineous of marriages. Future investigations on PSD will contribute to our progressing alternative targets for pathogenesis-based therapy. © 2011 The Authors. Journal of the European Academy of Dermatology and Venereology © 2011 European Academy of Dermatology and Venereology.

Evaluation of characteristics of a novel real-time dosimeter for patient's skin exposure

International Nuclear Information System (INIS)

Morishima, Yoshiaki; Katahira, Yoshiaki; Chiba, Hiroo; Chida, Koichi; Takeda, Ken; Onodera, Risa

2011-01-01

Findings are reported concerning the essential characteristics and clinical application of a novel Unfors' PSD (Patient Skin Dosimeter) in comparison with the previous Mcmahorn's SDM (Skin Dose Monitor, now commercially unavailable). The structure of PSD and SDM are essentially the same, in which the sensor (silicon semiconductor) is connected to the dose displaying part with cable. Used were X-ray machine for cardiac catheter of Toshiba KXO-80C (2.6 mm Al filter) under conditions of 15 pulses/sec, duration 3 ms, transillumination 1 min, FID (focus-image intensifier distance) 105 cm and tube voltage 50-125 kV, and 20 cm thick acryl phantom. PSD, SDM and Radcal 6 cc-thimble ionization chamber corrected by Japan Quality Assurance Organization, were placed behind the phantom. Properties were characterized for energy dependency (tube voltage), linearity of dose, reproducibility, irradiation field change (3-10 cm x 14 and 16 cm), and angle dependency. For clinical application, PSD was stuck on 3 sites of the back of 5 patients (4 M/1F, av. age 62 y) undergoing coronary angiography or percutaneous coronary intervention. Results were: PSD, better energy dependency than SDM; PSD and ADM, good linearity up to 2 Gy; both, good reproducibility; less effect of field change in SDM; PSD, better angle dependency than SDM; and cable/ sensor of PSD, imaged on the display at the actual clinical practice. It was concluded that PSD was of performance characteristics equal to or superior to SDM but should be improved further as its cable and sensor images in the display might hinder the operation or treatment site. (author)

Epigenetics: spotlight on type 2 diabetes and obesity.

Science.gov (United States)

Desiderio, A; Spinelli, R; Ciccarelli, M; Nigro, C; Miele, C; Beguinot, F; Raciti, G A

2016-10-01

Type 2 diabetes (T2D) and obesity are the major public health problems. Substantial efforts have been made to define loci and variants contributing to the individual risk of these disorders. However, the overall risk explained by genetic variation is very modest. Epigenetics is one of the fastest growing research areas in biomedicine as changes in the epigenome are involved in many biological processes, impact on the risk for several complex diseases including diabetes and may explain susceptibility. In this review, we focus on the role of DNA methylation in contributing to the risk of T2D and obesity.

Rheology of Colombian coal-water slurry fuels: Effect of particle-size distribution

Energy Technology Data Exchange (ETDEWEB)

Pulido, J E; Rojas, C P; Acero, G [Universidad Industrial de Santander, Bucaramanga (Colombia)

1996-12-31

Coal-water slurry fuels (CWSF`s) have been prepared and characterized in a research project in Colombia, sponsored by Colciencias and Ecocarbon, in order to evaluate the effects of the different composition variables on the behavior during preparation and pipe line transportation. The authors have previously presented details describing the characteristics of the slurry fuels prepared with five types of Colombian thermal coals and the influence of their chemical composition on the optimum particle-size distribution (PSD) required to prepare highly loaded and workable CWSF`s. The formulation and design of flow systems of suspensions with high solids content, such as the CWSF`s, require a detailed rheological knowledge of the suspension in terms of the governing parameters related to PSD, coal content, surface chemistry of the particles and dispersants used to stabilize the slurries. Important studies on these aspects have been reviewed and carried out experimentally by other authors specially devoted to the correlations between apparent viscosity, solids content and average coal particle-size. One of the targets to obtain an optimum control on the viscosity and flow properties of the CWSF`s must be based in correlating the Theological constants for the prevailing model of viscosity law to the characteristic parameters of the particle-size distribution and to the coal content in the slurry. In spite of the effect of PSD on the rheology of highly-loaded coal slurries have been long recognized as significant, the specific influence of the various PSD`s on the parameters of the Theological model continues to receive attention to further understanding in order to improve the slurry formulations for a specified purpose on preparation and hydraulic handling. This paper reports the results of an experimental technique of examining the various PSD`s on coal slurry fuel rheology, taking special attention for the effect on the parameters of the rheological model.

Post-stroke depression: an update.

Science.gov (United States)

Espárrago Llorca, G; Castilla-Guerra, L; Fernández Moreno, M C; Ruiz Doblado, S; Jiménez Hernández, M D

2015-01-01

Post-stroke depression (PSD) is the most common mood disorder following a stroke, and also the main factor limiting recovery and rehabilitation in stroke patients. In addition, it may increase mortality by up to ten times. PSD occurs in 1 in 3 stroke patients and more than half of all cases are neither diagnosed nor treated. Several mechanisms, including biological, behavioral, and social factors, are involved in its pathogenesis. Symptoms usually occur within the first three months after stroke (early onset PSD), and less frequently at a later time (late onset PSD). Symptoms resemble those of other types of depression, although there are some differences: PSD patients experience more sleep disturbances, vegetative symptoms, and social withdrawal. For PSD diagnosis, we recommended vigilance and use of specific diagnostic tools such as the Patient Health Questionnaire-2 (PHQ-2). The treatments of choice are selective serotonin reuptake inhibitors (SSRI). However, there are still many unanswered questions in the treatment of PSD, such as the best time to start treatment or the effects of antidepressants on cognition and motor function, among others. Neurologists play a pivotal role in the care and management of patients recovering from stroke. They must be familiar with methods for early detection and treatment of PSD, as this can facilitate a patient's functional recovery and social reintegration, and improve quality of life for patients and their families. Copyright © 2012 Sociedad Española de Neurología. Published by Elsevier Espana. All rights reserved.

Effects of environmental enrichment and paradoxical sleep deprivation on open-field behavior of amphetamine-treated mice.

Science.gov (United States)

Fukushiro, Daniela Fukue; Calzavara, Mariana Bendlin; Trombin, Thaís Fernanda; Lopez, Giorgia Batlle; Abílio, Vanessa Costhek; Andersen, Monica Levy; Tufik, Sergio; Frussa-Filho, Roberto

2007-11-23

Environmental enrichment or paradoxical sleep deprivation (PSD) has been shown to modify some responses elicited by drugs of abuse. The aims of the present study were to examine the effects of environmental enrichment and PSD, conducted separately or in association, on open-field behavior elicited by amphetamine (AMP) in mice. Male C57BL/6 mice were randomly assigned to live in either an enriched environmental condition (EC) or a standard environmental condition (SC) for 12 months since weaning. Some of the EC and SC mice were sleep deprived for 48 h, while others were maintained in their home-cages. Immediately after PSD or home-cage stay, the animals received an ip injection of saline, 2.5 mg/kg AMP or 5.0 mg/kg AMP. Fifteen minutes later, their open-field behavior was quantified. Whereas PSD enhanced total and peripheral locomotor activity of acutely AMP-treated mice, environmental enrichment presented only a trend toward enhancement. When PSD and environmental enrichment were combined, an increase in the total and peripheral locomotion frequencies of AMP-treated animals, similar to that observed after PSD, was revealed. In addition, PSD, environmental enrichment or their combination did not modify the effects of AMP on the other open-field behavioral parameters that were analyzed. The present findings demonstrate that some (but not all) of the behavioral effects caused by AMP acute administration can be similarly and specifically enhanced by both environmental enrichment and PSD in C57BL/6 mice.

January Monthly Spotlight: Cervical Health and Cervical Cancer Disparities

Science.gov (United States)

In January, CRCHD joins the nation in raising awareness for Cervical Health and Cervical Cancer Disparities. This month we share a special focus on NCI/CRCHD research programs that are trying to reduce cervical cancer disparities in underserved communities and the people who are spreading the word about the importance of early detection.

Effect of Antenna Pointing Errors on SAR Imaging Considering the Change of the Point Target Location

Science.gov (United States)

Zhang, Xin; Liu, Shijie; Yu, Haifeng; Tong, Xiaohua; Huang, Guoman

2018-04-01

Towards spaceborne spotlight SAR, the antenna is regulated by the SAR system with specific regularity, so the shaking of the internal mechanism is inevitable. Moreover, external environment also has an effect on the stability of SAR platform. Both of them will cause the jitter of the SAR platform attitude. The platform attitude instability will introduce antenna pointing error on both the azimuth and range directions, and influence the acquisition of SAR original data and ultimate imaging quality. In this paper, the relations between the antenna pointing errors and the three-axis attitude errors are deduced, then the relations between spaceborne spotlight SAR imaging of the point target and antenna pointing errors are analysed based on the paired echo theory, meanwhile, the change of the azimuth antenna gain is considered as the spotlight SAR platform moves ahead. The simulation experiments manifest the effects on spotlight SAR imaging caused by antenna pointing errors are related to the target location, that is, the pointing errors of the antenna beam will severely influence the area far away from the scene centre of azimuth direction in the illuminated scene.

Investigation of depth-of-interaction by pulse shape discrimination in multicrystal detectors read out by avalanche photodiodes

International Nuclear Information System (INIS)

Saoudi, A.; Pepin, C.M.; Dion, F.; Bentourkia, M.; Lecomte, R.; Dautet, H.

1999-01-01

The measurement of depth of interaction (DOI) within detectors is necessary to improve resolution uniformity across the FOV of small diameter PET scanners. DOI encoding by pulse shape discrimination (PSD) has definite advantages as it requires only one readout per pixel and it allows DOI measurement of photoelectric and Compton events. The PSD time characteristics of various scintillators were studied with avalanche photodiodes (APD) and the identification capability was tested in multi-crystal assemblies with up to four scintillators. In the PSD time spectrum of an APD-GSO/LSO/BGO/CsI(Tl) assembly, four distinct time peaks at 45, 26, 88 and 150 ns relative to a fast test pulse, having resolution of 10.6, 5.2, 20 and 27 ns, can be easily separated. Whereas the number and position of scintillators in the multi-crystal assemblies affect detector performance, the ability to identify crystals is not compromised. Compton events have a significant effect on PSD accuracy, suggesting that photopeak energy gating should be used for better crystal identification. However, more sophisticated PSD techniques using parametric time-energy histograms can also improve crystal identification in cases where PSD time or energy discrimination alone is inadequate. These results confirm the feasibility of PSD DOI encoding with APD-based detectors for PET

THE X-RAY POWER SPECTRAL DENSITY FUNCTION OF THE SEYFERT ACTIVE GALACTIC NUCLEUS NGC 7469

International Nuclear Information System (INIS)

Markowitz, A.

2010-01-01

We present the broadband X-ray power spectral density (PSD) function of the X-ray-luminous Seyfert 1.2 NGC 7469, measured from Rossi X-ray Timing Explorer monitoring data and two XMM-Newton observations. We find significant evidence for a turnover in the 2-10 keV PSD at a temporal frequency of 2.0 +3.0 -0.8 x 10 -6 Hz or 1.0 +3.0 -0.6 x 10 -6 Hz, depending on the exact form of the break (sharply broken or slowly bending power law, respectively). The 'surrogate' Monte Carlo method of Press et al. was used to map out the probability distributions of PSD model parameters and obtain reliable uncertainties (68% confidence limits quoted here). The corresponding break timescale of 5.8 ± 3.5 days or 11.6 +17.5 -8.7 days, respectively, is consistent with the empirical relation between PSD break timescale, black hole mass, and bolometric luminosity of McHardy et al. Compared to the 2-10 keV PSD, the 10-20 keV PSD has a much flatter shape at high temporal frequencies, and no PSD break is significantly detected, suggesting an energy-dependent evolution not unlike that exhibited by several Galactic black hole systems.

SU-F-P-44: A Direct Estimate of Peak Skin Dose for Interventional Fluoroscopy Procedures

International Nuclear Information System (INIS)

Weir, V; Zhang, J

2016-01-01

Purpose: There is an increasing demand for medical physicist to calculate peak skin dose (PSD) for interventional fluoroscopy procedures. The dose information (Dose-Area-Product and Air Kerma) displayed in the console cannot directly be used for this purpose. Our clinical experience shows that the use of the existing methods may overestimate or underestimate PSD. This study attempts to develop a direct estimate of PSD from the displayed dose metrics. Methods: An anthropomorphic torso phantom was used for dose measurements for a common fluoroscopic procedure. Entrance skin doses were measured with a Piranha solid state point detector placed on the table surface below the torso phantom. An initial “reference dose rate” (RE) measurement was conducted by comparing the displayed dose rate (mGy/min) to the dose rate measured. The distance from table top to focal spot was taken as the reference distance (RD at the RE. Table height was then adjusted. The displayed air kerma and DAP were recorded and sent to three physicists to estimate PSD. An inverse square correction was applied to correct displayed air kerma at various table heights. The PSD estimated by physicists and the PSD by the proposed method were then compared with the measurements. The estimated DAPs were compared to displayed DAP readings (mGycm2). Results: The difference between estimated PSD by the proposed method and direct measurements was less than 5%. For the same set of data, the estimated PSD by each of three physicists is different from measurements by ±52%. The DAP calculated by the proposed method and displayed DAP readings in the console is less than 20% at various table heights. Conclusion: PSD may be simply estimated from displayed air kerma or DAP if the distance between table top and tube focal spot or if x-ray beam area on table top is available.

SU-F-P-44: A Direct Estimate of Peak Skin Dose for Interventional Fluoroscopy Procedures

Energy Technology Data Exchange (ETDEWEB)

Weir, V [Baylor Scott and White Healthcare System, Dallas, TX (United States); Zhang, J [University of Kentucky, Lexington, KY (United States)

2016-06-15

Purpose: There is an increasing demand for medical physicist to calculate peak skin dose (PSD) for interventional fluoroscopy procedures. The dose information (Dose-Area-Product and Air Kerma) displayed in the console cannot directly be used for this purpose. Our clinical experience shows that the use of the existing methods may overestimate or underestimate PSD. This study attempts to develop a direct estimate of PSD from the displayed dose metrics. Methods: An anthropomorphic torso phantom was used for dose measurements for a common fluoroscopic procedure. Entrance skin doses were measured with a Piranha solid state point detector placed on the table surface below the torso phantom. An initial “reference dose rate” (RE) measurement was conducted by comparing the displayed dose rate (mGy/min) to the dose rate measured. The distance from table top to focal spot was taken as the reference distance (RD at the RE. Table height was then adjusted. The displayed air kerma and DAP were recorded and sent to three physicists to estimate PSD. An inverse square correction was applied to correct displayed air kerma at various table heights. The PSD estimated by physicists and the PSD by the proposed method were then compared with the measurements. The estimated DAPs were compared to displayed DAP readings (mGycm2). Results: The difference between estimated PSD by the proposed method and direct measurements was less than 5%. For the same set of data, the estimated PSD by each of three physicists is different from measurements by ±52%. The DAP calculated by the proposed method and displayed DAP readings in the console is less than 20% at various table heights. Conclusion: PSD may be simply estimated from displayed air kerma or DAP if the distance between table top and tube focal spot or if x-ray beam area on table top is available.

Long-term evolution of brainstem electrical evoked responses to sound after restricted ablation of the auditory cortex.

Directory of Open Access Journals (Sweden)

Verónica Lamas

Full Text Available INTRODUCTION: This study aimed to assess the top-down control of sound processing in the auditory brainstem of rats. Short latency evoked responses were analyzed after unilateral or bilateral ablation of auditory cortex. This experimental paradigm was also used towards analyzing the long-term evolution of post-lesion plasticity in the auditory system and its ability to self-repair. METHOD: Auditory cortex lesions were performed in rats by stereotactically guided fine-needle aspiration of the cerebrocortical surface. Auditory Brainstem Responses (ABR were recorded at post-surgery day (PSD 1, 7, 15 and 30. Recordings were performed under closed-field conditions, using click trains at different sound intensity levels, followed by statistical analysis of threshold values and ABR amplitude and latency variables. Subsequently, brains were sectioned and immunostained for GAD and parvalbumin to assess the location and extent of lesions accurately. RESULTS: Alterations in ABR variables depended on the type of lesion and post-surgery time of ABR recordings. Accordingly, bilateral ablations caused a statistically significant increase in thresholds at PSD1 and 7 and a decrease in waves amplitudes at PSD1 that recover at PSD7. No effects on latency were noted at PSD1 and 7, whilst recordings at PSD15 and 30 showed statistically significant decreases in latency. Conversely, unilateral ablations had no effect on auditory thresholds or latencies, while wave amplitudes only decreased at PSD1 strictly in the ipsilateral ear. CONCLUSION: Post-lesion plasticity in the auditory system acts in two time periods: short-term period of decreased sound sensitivity (until PSD7, most likely resulting from axonal degeneration; and a long-term period (up to PSD7, with changes in latency responses and recovery of thresholds and amplitudes values. The cerebral cortex may have a net positive gain on the auditory pathway response to sound.

Spotlight: French Polynesia.

Science.gov (United States)

May, J F

1988-01-01

French Polynesia is a group of 4 archipelagos in the South Pacific with an estimated 1987 population of 176,600. Its people are mainly Tahitians, Polynesians, Chinese, Europeans, and persons of mixed heritage. More than half of the population live in the Society Islands. About half of the population is less than 20 years old and slightly more than 5% is older than 60. Due to a recent decline in fertility, the rate of natural increase is moderate--about 2.5% annually. In the early 1980s, about two thirds of women in Tahiti aged 15-49 used a modern method of contraception. It remains to be seen whether this pattern will spread to the entire area. Projections by the World Bank, assuming little decline in mortality, yield a total population of 400,000 by the year 2030. The major challenge for French Polynesia is to develop the many small islands spread across an ocean territory half the size of the contiguous 48 states of the U.S. Tourist-related activities have replaced traditional income-generating such as production of coconuts, mother-of-pearl, and vanilla. The value of exports from the area make up only 5% of the value of imports. To extract the potentially huge food and mineral resources from the ocean, enormous infusions of capital will be necessary.

Spotlight on Solutions.

Science.gov (United States)

Spoor, Dana L.

1997-01-01

Presents interviews with five school administrators, representing a variety of school systems. Discusses their strategies for addressing concerns that all school systems share. Using a question and answer format, the article focuses on handicap accessibility, energy management, funding, security, and technology. (RJM)

Spotlight on Spelling.

Science.gov (United States)

Hardin County Board of Education, Elizabethtown, KY.

Word lists and class activities are suggested for improving the spelling of elementary school students. The word lists contain rhyming words, antonyms, synonyms, homonyms, 100 spelling demons, look-alike words that are easily confused, and content area words (for geography, mathematics, science, sports, music, social studies). The suggested…

Sri Lanka. Spotlight.

Science.gov (United States)

Hoque, M N

1985-01-01

Sri Lanka, an island country off the southeastern coast of India, populated by an estimated 16.1 million inhabitants, was one of the 1st developing countries to adopt a population policy aimed at reducing population growth and redistributing the population more equitably throughout the country. Population density is high. There are 636 persons/square mile, and 2/3 of the population lives in the southwestern and central regions of the country. Government redistribution policies seek to increase internal migration flows to the drier and less populated areas. The country's birth rate was 27 in 1982, the death rate was 6 in 1981, and the infant mortality rate was 34.4 in 1980. The rate of natural increase in 1982 was 2.1%, and the population growth rate declined from 2.5% prior to 1970 to 1.7% in 1980. The total fertility rate declined between 1963-74 from 5.0-3.4 and then increased to 3.7 in recent years. Given the age structure of the population, the population is expected to continue growing at a high rate in the coming years; however, the age at marriage is increasing and the proportion of young married women in the population is declining, and these trends will have an impact on population growth. These trends are due in part to increased educational and employment opportunities for women. The delay in marriage may also be linked to the dowry system. Given the high rate of poverty, it is difficult for parents to accummulate sufficient resources to provide dowries for their daughters. Sri lanka's economy is predominantly agricultural, with only 15% of the gross national product derived from manufacturing. Approximately 22% of thepopulation lives in urban areas. In 1981 exports totaled US$1.1 billion, and major export items were tea and rubber. In the same year, imports totaled US$1.8 billion and consisted primarily of food, petroleum, and fertilizers. The per capita gross national product was US$320 in 1982. Sri Lanka receives considerable foreign aid, and the country's family planning program receives substantial outside support.

Spotlight on Peru.

Science.gov (United States)

1997-01-01

Lima's population grew from 1 million to 7 million during 1969-89, almost entirely due to rural-urban immigration. Other urban areas such as Iquitos experienced similar growth over the period. National, regional, and municipal governments have been working to restore civil order in the country and to bring basic health, sanitation, and education programs to the population. However, language, attitudinal, and cultural differences impede progress in this diverse and changing country. Peru's young population of median age 21 years presents a challenge to the development and implementation of effective reproductive health care programs for the country. Pathfinder's work in Peru is helped by current President Alberto Fujimori's strong and active support for family planning. In the face of strong opposition from the Roman Catholic Church, President Fujimori has held onto his conviction and commitment to reduce levels of maternal morbidity and mortality in Peru by increasing the accessibility of family planning programs. Pathfinder's work in Peru with the US Agency for International Development (USAID) includes the 5-year program Project 2000 designed to improve maternal and child health in 12 priority regions of the country. Pathfinder is also working with USAID to link family planning to postpartum services in 30 public hospitals throughout the country. New programs will be launched with contributions from individuals and foundations.

Comparison between time-step-integration and probabilistic methods in seismic analysis of a linear structure

International Nuclear Information System (INIS)

Schneeberger, B.; Breuleux, R.

1977-01-01

Assuming that earthquake ground motion is a stationary time function, the seismic analysis of a linear structure can be done by probailistic methods using the 'power spectral density function' (PSD), instead of applying the more traditional time-step-integration using earthquake time histories (TH). A given structure was analysed both by PSD and TH methods computing and comparing 'floor response spectra'. The analysis using TH was performed for two different TH and different frequency intervals for the 'floor-response-spectra'. The analysis using PSD first produced PSD functions of the responses of the floors and these were then converted into 'foor-response-spectra'. Plots of the resulting 'floor-response-spectra' show: (1) The agreement of TH and PSD results is quite close. (2) The curves produced by PSD are much smoother than those produced by TH and mostly form an enelope of the latter. (3) The curves produced by TH are quite jagged with the location and magnitude of the peaks depending on the choice of frequencies at which the 'floor-response-spectra' were evaluated and on the choice of TH. (Auth.)

Pulse shape discrimination using EJ-299-33 plastic scintillator coupled with a Silicon Photomultiplier array

International Nuclear Information System (INIS)

Liao, Can; Yang, Haori

2015-01-01

Recent developments in organic plastic scintillators capable of pulse shape discrimination (PSD) have gained much interest. Novel photon detectors, such as Silicon Photomultipliers (SiPMs), offer numerous advantages and can be used as an alternative to conventional photo multiplier tubes (PMTs) in many applications. In this work, we evaluate the PSD performance of the EJ-299-33 plastic scintillator coupled with a SiPM array. 2D PSD plots as well as the Figure of Merit (FOM) parameters are presented to demonstrate the PSD capability of EJ-299-33 using a SiPM as the light sensor. The best FOM of 0.76 was observed with a 1.0 MeVee (MeV-electron-equivalent) energy threshold, despite the high noise level of the SiPM array. A high-speed digital oscilloscope was used to acquire data, which was then processed offline in MATLAB. A performance comparison between two different PSD algorithms was carried out. The dependence of PSD quality on the sampling rate was also evaluated, stimulated by the interest to implement this setup for handheld applications where power consumption is crucial

Evaluating Disease Severity in Chronic Pain Patients with and without Fibromyalgia: A Comparison of the Symptom Impact Questionnaire and the Polysymptomatic Distress Scale.

Science.gov (United States)

Friend, Ronald; Bennett, Robert M

2015-12-01

To compare the relative effectiveness of the Polysymptomatic Distress Scale (PSD) with the Symptom Impact Questionnaire (SIQR), the disease-neutral revision of the updated Fibromyalgia Impact Questionnaire (FIQR), in their ability to assess disease activity in patients with rheumatic disorders both with and without fibromyalgia (FM). The study included 321 patients from 8 clinical practices with some 16 different chronic pain disorders. Disease severity was assessed by the Medical Outcomes Study Short Form-36 (SF-36). Univariate analyses were used to assess the magnitude of PSD and SIQR correlations with SF-36 subscales. Hierarchical stepwise regression was used to evaluate the unique contribution of the PSD and SIQR to the SF-36. Random forest regression probed the relative importance of the SIQR and PSD components as predictors of SF-36. The correlations with the SF-36 subscales were significantly higher for the SIQR (0.48 to 0.78) than the PSD (0.29 to 0.56; p FIQ, has several important advantages over the PSD in the evaluation of disease severity in chronic pain disorders.

WorldWideScience.org: Bringing Light to Grey

OpenAIRE

Hitson, Brian A. (OSTI-DOE); Johnson, Lorrie A. (OSTI-DOE); GreyNet, Grey Literature Network Service

2008-01-01

WorldWideScience.org and its governance structure, the WorldWideScience Alliance, are putting a brighter spotlight on grey literature. Through this new tool, grey literature is getting broader exposure to audiences all over the world. Improved access to and sharing of research information is the key to accelerating progress and breakthroughs in any field, especially science. Includes: Conference preprint, Powerpoint presentation, Abstract and Biographical notes, Pratt student commentary ...

The buck stops here.

Science.gov (United States)

Shinkman, R

1998-08-03

As Allegheny Health, Education and Research Foundation muddles through its high-profile bankruptcy reorganization, the spotlight of public scrutiny is now shining brightly on the system's board members, who were supposed to act as guardians of the not-for-profit system. "When things fall apart, the board members usually take the heat," says one governance expert. "And they should take the heat, since they are the final buffer."

The utility of presacral drainage in penetrating rectal injuries in adult and pediatric patients.

Science.gov (United States)

Savoie, Kate B; Beazley, Thomas M; Cleveland, Brent; Khaneki, Sina; Markel, Troy A; Hammer, Peter M; Savage, Stephanie; Williams, Regan F

2017-11-01

With changing weaponry associated with injuries in civilian trauma, there is no clinical census on the utility of presacral drainage (PSD) in penetrating rectal injuries (PRIs), particularly in pediatric patients. Patients with PRI from July 2004-June 2014 treated at two free-standing children's hospitals and two adult level 1 trauma centers were compared by age (pediatric patients ≤16 years) and PSD. A stratified analysis was performed based on age. The primary outcome was pelvic/presacral abscess. We identified 81 patients with PRI; 19 pediatric, 62 adult. Forty patients had PSD; only three pediatric patients had a drain. Adult patients were more likely to have sustained gunshot wounds (84%), whereas pediatric patients were more likely to sustain impalement injuries (59%). Pediatric patients were more likely to have distal extraperitoneal injuries (56% versus 27% in adults, P = 0.03). PSD was more common in adult patients (59% versus 14%, P = 0.0004), African-Americans (71% versus 11% Caucasian, P adult and pediatric patients. There were three cases of pelvic/presacral abscess, all in the adult patients (P = 0.31); one patient with PSD and two without PSD (P = 0.58). In stratified analysis, there were no differences in any infectious complication between those with and without PSD. Pelvic/presacral abscess is a rare complication of PRI, especially in pediatric patients. PSD is not associated with decreased rates of infectious complications and may not be necessary in the treatment of PRI. Copyright © 2017 Elsevier Inc. All rights reserved.

Hysteresis in suspended sediment to turbidity relations due to changing particle size distributions

Science.gov (United States)

Landers, Mark N.; Sturm, Terry W.

2013-01-01

Turbidity (T) is the most ubiquitous of surrogate technologies used to estimate suspended-sediment concentration (SSC). The effects of sediment size on turbidity are well documented; however, effects from changes in particle size distributions (PSD) are rarely evaluated. Hysteresis in relations of SSC-to-turbidity (SSC~T) for single stormflow events was observed and quantified for a data set of 195 concurrent measurements of SSC, turbidity, discharge, velocity, and volumetric PSD collected during five stormflows in 2009–2010 on Yellow River at Gees Mill Road in metropolitan Atlanta, Georgia. Regressions of SSC-normalized turbidity (T/SSC) on concurrently measured PSD percentiles show an inverse, exponential influence of particle size on turbidity that is not constant across the size range of the PSD. The majority of the influence of PSD on T/SSC is from particles of fine-silt and smaller sizes (finer than 16 microns). This study shows that small changes in the often assumed stability of the PSD are significant to SSC~T relations. Changes of only 5 microns in the fine silt and smaller size fractions of suspended sediment PSD can produce hysteresis in the SSC~T rating that can increase error and produce bias. Observed SSC~T hysteresis may be an indicator of changes in sediment properties during stormflows and of potential changes in sediment sources. Trends in the PSD time series indicate that sediment transport is capacity-limited for sand-sized sediment in the channel and supply-limited for fine silt and smaller sediment from the hillslope.

Spotlight on middle childhood: Rejuvenating the 'forgotten years'.

Science.gov (United States)

Mah, V Kandice; Ford-Jones, E Lee

2012-02-01

Middle childhood, from six to 12 years of age, is often known as the 'forgotten years' of development because most research is focused on early childhood development or adolescent growth. However, middle childhood is rich in potential for cognitive, social, emotional and physical advancements. During this period, the brain is actively undergoing synaptic pruning and, as such, is constantly becoming more refined, a process that is heavily dependent on a child's environment. This discovery opens the door to optimizing the experiences a child needs to provide themselves with a strong foundation for adulthood. The present article reviews the neurological changes that occur in middle childhood, their impact on overall development and how to implement this knowledge to augment a child's capabilities.

A Prospective Study on the Prevalence and Risk Factors of Poststroke Depression

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A. De Ryck

2013-01-01

Full Text Available Background and Purpose: Poststroke depression (PSD is common. Early detection of depressive symptoms and identification of patients at risk for PSD are important as PSD negatively affects stroke outcome and costs of medical care. Therefore, the aim of this study was to determine incidence and risk factors for PSD at 3 months after stroke. Methods: We conducted a prospective, longitudinal epidemiological study aiming to determine incidence and risk factors for PSD at 1, 3, 6, 12 and 18 months poststroke. The present data analysis covers the convalescent phase of 3 months poststroke. Participants in this study were inpatients, admitted to a stroke unit with first or recurrent stroke. Demographic data and vascular risk factors were collected and patients were evaluated at baseline and 3 months poststroke for functional and cognitive deficits, stroke characteristics, stroke severity and stroke outcome. Signs and symptoms of depression were quantified by means of the Cornell Scale for Depression (CSD and Montgomery and Åsberg Depression Rating Scale (MADRS. Significantly associated variables from univariate analysis were analyzed by using multiple linear and logistic regression methods. Results: Data analysis was performed in 135 patients who completed follow-up assessments at 3 months poststroke. Depression (CSD score ≥8 was diagnosed in 28.1% of the patients. Patients with PSD were significantly more dependent with regard to activities of daily living (ADL and displayed more severe physical and cognitive impairment than patients without PSD. A higher prevalence of speech and language dysfunction and apraxia were observed in patients with PSD (36.8 and 34.3%, respectively compared to non-depressed stroke patients (19.6 and 12.4%; p = 0.036 and p = 0.004, respectively. Applying multiple linear regressions, cognitive impairment and reduced mobility as part of the Stroke Impact Scale were independently associated with PSD, as scored using CSD and

Progesterone reduces erectile dysfunction in sleep-deprived spontaneously hypertensive rats

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Tufik Sergio

2007-03-01

Full Text Available Abstract Background Paradoxical sleep deprivation (PSD associated with cocaine has been shown to enhance genital reflexes (penile erection-PE and ejaculation-EJ in Wistar rats. Since hypertension predisposes males to erectile dysfunction, the aim of the present study was to investigate the effects of PSD on genital reflexes in the spontaneously hypertensive rat (SHR compared to the Wistar strain. We also extended our study to examine how PSD affect steroid hormone concentrations involved in genital events in both experimental models. Methods The first experiment investigated the effects of PSD on genital reflexes of Wistar and SHR rats challenged by saline and cocaine (n = 10/group. To further examine the impact of the PSD on concentrations of sexual hormones, we performed a hormonal analysis of testosterone and progesterone in the Wistar and in SHR strains. Since after PSD progesterone concentrations decreased in the SHR compared to the Wistar PSD group we extended our study by investigating whether progesterone (25 mg/kg or 50 mg/kg or testosterone (0.5 mg/kg or 1.0 mg/kg administration during PSD would have a facilitator effect on the occurrence of genital reflexes in this hypertensive strain. Results A 4-day period of PSD induced PE in 50% of the Wistar rats against 10% for the SHR. These genital reflexes was potentiated by cocaine in Wistar rats whereas this scenario did not promote significant enhancement in PE and EJ in hypertensive rats, and the percentage of SHR displaying genital reflexes still figured significantly lower than that of the Wistar strain. As for hormone concentrations, both sleep-deprived Wistar and SHR showed lower testosterone concentrations than their respective controls. Sleep deprivation promoted an increase in concentrations of progesterone in Wistar rats, whereas no significant alterations were found after PSD in the SHR strain, which did not present enhancement in erectile responses. In order to explore the role

Research Frontiers and Way Forward

Science.gov (United States)

Bahron, H.

2018-02-01

home, Malaysia is rapidly approaching the end of Wawasan 2020 and a new set of targets under Transformasi Nasional 2050 (TN50) have been set to guide the nation’s journey into the year 2050. The goal is to be within the top 20 of world’s nation in economic development, social progress and innovation. There are seven thrusts in TN50 that encompass all aspects of a mature and well- endowed nation. The welfare of the bottom 40% of the people of Malaysia is given a special attention by a dedicated effort the B40 agenda in elevating their socio-economic status. UiTM has designed an approach to develop a lush research ecosystem based on a synergic and concerted move of bringing its workforce in the faculties on a transdisciplinary platform of Communities of Research (CoRe). The effect of CoRe is very much apparent in research spotlights of UiTM competency map that shows a definite healthy growth towards multi- and interdisciplinary research activities.

Familias homoparentales: relatos desde la perspectiva de los “conocimientos situados”

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Analía Buzaglo

2015-12-01

Full Text Available This paper aims to enquire into the contributions of feminist epistemology to critical research in Social Sciences. Our starting point is a single situated research: “Homoparental Families: Counter hegemonic narratives of parenthood”, based on the methodology of narrative production that deals with Donna Haraway's approach of “situated knowledge” (1995. This narratives question hegemonic theories and practice that have concrete effects on homoparental families’ lives—often related to the suffering and stigmatization of its members—bringing into the spotlight the creation of innovative, singular ways of living in our society.

Size Distribution and Rate of Dust Generated During Grain Elevator Handling

Science.gov (United States)

Dust generated during grain handling is an air pollutant that produces safety and health hazards. This study was conducted to characterize the particle size distribution (PSD) of dust generated during handling of wheat and shelled corn in the research elevator of the USDA Grain Marketing and Product...

The Role of Resolution in the Estimation of Fractal Dimension Maps From SAR Data

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Gerardo Di Martino

2017-12-01

Full Text Available This work is aimed at investigating the role of resolution in fractal dimension map estimation, analyzing the role of the different surface spatial scales involved in the considered estimation process. The study is performed using a data set of actual Cosmo/SkyMed Synthetic Aperture Radar (SAR images relevant to two different areas, the region of Bidi in Burkina Faso and the city of Naples in Italy, acquired in stripmap and enhanced spotlight modes. The behavior of fractal dimension maps in the presence of areas with distinctive characteristics from the viewpoint of land-cover and surface features is discussed. Significant differences among the estimated maps are obtained in the presence of fine textural details, which significantly affect the fractal dimension estimation for the higher resolution spotlight images. The obtained results show that if we are interested in obtaining a reliable estimate of the fractal dimension of the observed natural scene, stripmap images should be chosen in view of both economic and computational considerations. In turn, the combination of fractal dimension maps obtained from stripmap and spotlight images can be used to identify areas on the scene presenting non-fractal behavior (e.g., urban areas. Along this guideline, a simple example of stripmap-spotlight data fusion is also presented.

Effect of sildenafil (Viagra® on the genital reflexes of paradoxical sleep-deprived male rats

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M.L. Andersen

2007-11-01

Full Text Available Since there is evidence that paradoxical sleep deprivation (PSD elicits penile erection (PE and ejaculation (EJ, and that the erectile response of rats is mediated by nitric oxide, the present study sought to extend the latter finding by assessing the effects of sildenafil on the genital reflexes of male Wistar rats subjected to PSD. We also determined the influence of sildenafil on hormone concentrations. In the first experiment, sildenafil at doses ranging from 0.08 to 0.32 mg/kg was administered intraperitoneally to rats that had been deprived of sleep for 4 days and to home cage controls (N = 8-10/group. The frequency of PE and EJ was measured for 60 min. PSD alone induced PE in 50% of the animals; however, a single injection of sildenafil did not significantly increase the percentage of rats displaying PE compared to PSD-saline or to home cage groups. PSD alone also induced spontaneous EJ, but this response was not potentiated by sildenafil in the dose range tested. Testosterone concentrations were significantly lower in PSD rats (137 ± 22 ng/dL than in controls (365 ± 38 ng/dL, whereas progesterone (0.9 ± 0.1 vs 5.4 ± 1 ng/mL and plasma dopamine (103.4 ± 30 vs 262.6 ± 77 pg/mL increased. These changes did not occur after sildenafil treatment. The data show that although sildenafil did not alter the frequency of genital reflexes, it antagonized hormonal (testosterone and progesterone and plasma dopamine changes induced by PSD. The stimulation of the genital reflexes by sildenafil did not result in potentiating effects in PSD rats.

Optimization of PHEV Power Split Gear Ratio to Minimize Fuel Consumption and Operation Cost

Science.gov (United States)

Li, Yanhe

A Plug-in Hybrid Electric Vehicle (PHEV) is a vehicle powered by a combination of an internal combustion engine and an electric motor with a battery pack. The battery pack can be charged by plugging the vehicle to the electric grid and from using excess engine power. The research activity performed in this thesis focused on the development of an innovative optimization approach of PHEV Power Split Device (PSD) gear ratio with the aim to minimize the vehicle operation costs. Three research activity lines have been followed: • Activity 1: The PHEV control strategy optimization by using the Dynamic Programming (DP) and the development of PHEV rule-based control strategy based on the DP results. • Activity 2: The PHEV rule-based control strategy parameter optimization by using the Non-dominated Sorting Genetic Algorithm (NSGA-II). • Activity 3: The comprehensive analysis of the single mode PHEV architecture to offer the innovative approach to optimize the PHEV PSD gear ratio.

The magnetic structure and palaeomagnetic recording fidelity of sub-micron greigite (Fe3S4)

Science.gov (United States)

Valdez-Grijalva, Miguel A.; Nagy, Lesleis; Muxworthy, Adrian R.; Williams, Wyn; Fabian, Karl

2018-02-01

We present the results of a finite-element micromagnetic model of 30nm to 300nm greigite (Fe3S4) grains with a variety of equant morphologies. This grain size range covers the magnetic single-domain (SD) to pseudo single-domain (PSD) transition, and possibly also the PSD to multi-domain (MD) transition. The SD-PSD threshold d0 is determined to be 50nm ≤d0 ≤ 56nm depending on grain shape. The nudged elastic-band method was used to determine the room temperature energy barriers between stable states and thus the blocking volumes. It is found that, in the absence of interparticle magnetostatic interactions, the magnetisation of equant SD greigite is not stable on a geological scale and only PSD grains ≥ 70nm can be expected to carry a stable magnetisation over billion-year timescales, i.e., all non-interacting SD particles are essentially superparamagnetic. We further identify a mechanism for the PSD to multi-domain (MD) transition, which is of a continuous nature from PSD nucleation up to 300nm, when structures typical of MD behaviour like closure domains begin to form.

Determinants of Psychosocial Difficulties Experienced by Persons with Brain Disorders: Towards a 'Horizontal Epidemiology' Approach.

Directory of Open Access Journals (Sweden)

Carla Sabariego

Full Text Available Persons with brain disorders experience significant psychosocial difficulties (PSD in daily life, e.g. problems with managing daily routine or emotional lability, and the level of the PSD depends on social, physical and political environments, and psychologic-personal determinants. Our objective is to determine a brief set of environmental and psychologic-personal factors that are shared determinants of PSD among persons with different brain disorders.Cross-sectional study, convenience sample of persons with either dementia, stroke, multiple sclerosis, epilepsy, migraine, depression, schizophrenia, substance dependence or Parkinson's disease. Random forest regression and classical linear regression were used in the analyses.722 subjects were interviewed in four European countries. The brief set of determinants encompasses presence of comorbidities, health status appraisal, stressful life events, personality changes, adaptation, self-esteem, self-worth, built environment, weather, and health problems in the family.The identified brief set of common determinants of PSD can be used to support the implementation of cross-cutting interventions, social actions and policy tools to lower PSD experienced by persons with brain disorders. This set complements a recently proposed reliable and valid direct metric of PSD for brain disorders called PARADISE24.

Bridge scour conference shares knowledge and innovations : Tech Transfer Spotlight

Science.gov (United States)

2018-01-01

The National Cooperative Highway Research Programs Domestic Scan (NCHRP Project 20-68A) on bridge scour risk management brought more than 30 national bridge scour experts together for a week in July 2016 to examine ways to prevent and remediate br...

Participatory System Dynamics Modeling: Increasing Stakeholder Engagement and Precision to Improve Implementation Planning in Systems.

Science.gov (United States)

Zimmerman, Lindsey; Lounsbury, David W; Rosen, Craig S; Kimerling, Rachel; Trafton, Jodie A; Lindley, Steven E

2016-11-01

Implementation planning typically incorporates stakeholder input. Quality improvement efforts provide data-based feedback regarding progress. Participatory system dynamics modeling (PSD) triangulates stakeholder expertise, data and simulation of implementation plans prior to attempting change. Frontline staff in one VA outpatient mental health system used PSD to examine policy and procedural "mechanisms" they believe underlie local capacity to implement evidence-based psychotherapies (EBPs) for PTSD and depression. We piloted the PSD process, simulating implementation plans to improve EBP reach. Findings indicate PSD is a feasible, useful strategy for building stakeholder consensus, and may save time and effort as compared to trial-and-error EBP implementation planning.

Postsynaptic density protein 95-regulated NR2B tyrosine phosphorylation and interactions of Fyn with NR2B in levodopa-induced dyskinesia rat models

Directory of Open Access Journals (Sweden)

Ba M

2014-12-01

Full Text Available Maowen Ba,1,* Min Kong,2,* Guozhao Ma3 1Department of Neurology, Yuhuangding Hospital, Yantai City, Shandong, People’s Republic of China; 2Department of Neurology, Yantaishan Hospital, Yantai City, Shandong, People’s Republic of China; 3Department of Neurology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, People’s Republic of China *These authors contributed equally to this work Context: Abnormality in interactions between N-methyl-d-aspartate (NMDA receptor and its signaling molecules occurs in the lesioned striatum in Parkinson’s disease (PD and levodopa-induced dyskinesia (LID. It was reported that Fyn-mediated NR2B tyrosine phosphorylation, can enhance NMDA receptor function. Postsynaptic density protein 95 (PSD-95, one of the synapse-associated proteins, regulates interactions between receptor and downstream-signaling molecules. In light of the relationship between PSD-95, NR2B, and Fyn kinases, does PSD-95 contribute to the overactivity of NMDA receptor function induced by dopaminergic treatment? To further prove the possibility, the effects of regulating the PSD-95 expression on the augmented NR2B tyrosine phosphorylation and on the interactions of Fyn and NR2B in LID rat models were evaluated.Methods: In the present study, parkinsonian rat models were established by injecting 6-hydroxydopamine. Subsequently, valid PD rats were treated with levodopa (50 mg/kg/day with benserazide 12.5 mg/kg/day, twice daily intraperitoneally for 22 days to create LID rat models. Then, the effect of pretreatment with an intrastriatal injection of the PSD-95mRNA antisense oligonucleotides (PSD-95 ASO on the rotational response to levodopa challenge was assessed. The effects of pretreatment with an intrastriatal injection of PSD-95 ASO on the augmented NR2B tyrosine phosphorylation and interactions of Fyn with NR2B in the LID rat models were detected by immunoblotting and immunoprecipitation. Results: Levodopa

Gamma–neutron imaging system utilizing pulse shape discrimination with CLYC

International Nuclear Information System (INIS)

Whitney, Chad M.; Soundara-Pandian, Lakshmi; Johnson, Erik B.; Vogel, Sam; Vinci, Bob; Squillante, Michael; Glodo, Jarek; Christian, James F.

2015-01-01

Recently, RMD has investigated the use of CLYC (Cs 2 LiYCl 6 :Ce), a new and emerging scintillation material, in a gamma–neutron coded aperture imaging system based on RMD's commercial RadCam TM instrument. CLYC offers efficient thermal neutron detection, fast neutron detection capabilities, excellent pulse shape discrimination (PSD), and gamma-ray energy resolution as good as 4% at 662 keV. PSD improves the isolation of higher energy gammas from thermal neutron interactions (>3 MeV electron equivalent peak), compared to conventional pulse height techniques. The scintillation emission time in CLYC provides the basis for PSD; where neutron interactions result in a slower emission rise and decay components while gamma interactions result in a faster emission components. By creating a population plot based on the ratio of the decay tail compared to the total integral amplitude (PSD ratio), discrimination of gammas, thermal neutrons, and fast neutrons is possible. Previously, we characterized the CLYC-based RadCam system for imaging gammas and neutrons using a layered W-Cd coded aperture mask and employing only pulse height discrimination. In this paper, we present the latest results which investigate gamma-neutron imaging capabilities using PSD. An FPGA system is used to acquire the CLYC–PSPMT last dynode signals, determine a PSD ratio for each event, and compare it to a calibrated PSD cutoff. Each event is assigned either a gamma (low) or neutron (high) flag signal which is then correlated with the imaging information for each event. - Highlights: • The latest results are presented for our CLYC RadCam-2 system which investigate gamma–neutron imaging using pulse shape discrimination. • CLYC RadCam-2 system successfully discriminates gammas, thermal neutrons, and fast neutrons by employing a fully integrated, FPGA-based PSD system. • Imaging of our 252 Cf source was possible using both pulse height and pulse shape discrimination with CLYC. • Imaging

A novel strategy for pharmaceutical cocrystal generation without knowledge of stoichiometric ratio: myricetin cocrystals and a ternary phase diagram.

Science.gov (United States)

Hong, Chao; Xie, Yan; Yao, Yashu; Li, Guowen; Yuan, Xiurong; Shen, Hongyi

2015-01-01

To develop a streamlined strategy for pharmaceutical cocrystal preparation without knowledge of the stoichiometric ratio by preparing and characterizing the cocrystals of myricetin (MYR) with four cocrystal coformers (CCF). An approach based on the phase solubility diagram (PSD) was used for MYR cocrystals preparation and the solid-state properties were characterized by differential scanning calorimetry (DSC), fourier transform-infrared spectroscopy (FT-IR), powder X-ray diffraction (PXRD), and scanning electron microscopy (SEM). The ternary phase diagram (TPD) was constructed by combining the PSD and nuclear magnetic resonance (NMR) data. After that, the TPD was verified by traditional methods. The dissolution of MYR in the four cocrystals and pure MYR within three different media were also evaluated. A simple research method for MYR cocrystal preparation was obtained as follows: first, the PSD of MYR and CCF was constructed and analyzed; second, by transforming the curve in the PSD to a TPD, a region of pure cocrystals formation was exhibited, and then MYR cocrystals were prepared and identified by DSC, FT-IR, PXRD, and SEM; third, with the composition of the prepared cocrystal from NMR, the TPD of the MYR-CCF-Solvent system was constructed. The powder dissolution data showed that the solubility and dissolution rate of MYR was significantly enhanced by the cocrystals. A novel strategy for pharmaceutical cocrystals preparation without knowledge of the stoichiometric ratio based on the TPD was established and MYR cocrystals were successfully prepared. The present study provides a systematic approach for pharmaceutical cocrystal generation, which benefits the development and application of cocrystal technology in drug delivery.

CYLD, a deubiquitinase specific for lysine63-linked polyubiquitins, accumulates at the postsynaptic density in an activity-dependent manner

International Nuclear Information System (INIS)

Dosemeci, Ayse; Thein, Soe; Yang, Yijung; Reese, Thomas S.; Tao-Cheng, Jung-Hwa

2013-01-01

Highlights: ► CYLD is a deubiquitinase specific for lysine63-linked polyubiquitins. ► Presence of CYLD in PSDs is established by biochemistry and immunoEM. ► CYLD accumulates on PSDs upon depolarization of neurons. ► Accumulation of CYLD at PSDs may regulate trafficking/degradation of synaptic proteins. -- Abstract: Polyubiquitin chains on proteins flag them for distinct fates depending on the type of polyubiquitin linkage. While lysine48-linked polyubiquitination directs proteins to proteasomal degradation, lysine63-linked polyubiquitination promotes different protein trafficking and is involved in autophagy. Here we show that postsynaptic density (PSD) fractions from adult rat brain contain deubiquitinase activity that targets both lysine48 and lysine63-linked polyubiquitins. Comparison of PSD fractions with parent subcellular fractions by Western immunoblotting reveals that CYLD, a deubiquitinase specific for lysine63-linked polyubiquitins, is highly enriched in the PSD fraction. Electron microscopic examination of hippocampal neurons in culture under basal conditions shows immunogold label for CYLD at the PSD complex in approximately one in four synapses. Following depolarization by exposure to high K+, the proportion of CYLD-labeled PSDs as well as the labeling intensity of CYLD at the PSD increased by more than eighty percent, indicating that neuronal activity promotes accumulation of CYLD at the PSD. An increase in postsynaptic CYLD following activity would promote removal of lysine63-polyubiquitins from PSD proteins and thus could regulate their trafficking and prevent their autophagic degradation.

Applying dual-laser spot positions measurement technology on a two-dimensional tracking measurement system

International Nuclear Information System (INIS)

Lee, Hau-Wei; Chen, Chieh-Li

2009-01-01

This paper presents a two-dimensional tracking measurement system with a tracking module, which consists of two stepping motors, two laser diodes and a four separated active areas segmented position sensitive detector (PSD). The PSD was placed on a two-dimensional moving stage and used as a tracking target. The two laser diodes in the tracking module were directly rotated to keep the laser spots on the origin of the PSD. The two-dimensional position of the target PSD on the moving stage is determined from the distance between the two motors and the tracking angles of the two laser diodes, which are rotated by the two stepping motors, respectively. In order to separate the four positional values of the two laser spots on one PSD, the laser diodes were modulated by two distinct frequencies. Multiple-laser spot position measurement technology was used to separate the four positional values of the two laser spots on the PSD. The experimental results show that the steady-state voltage shift rate is about 0.2% and dynamic cross-talk rate is smaller than 2% when the two laser spots are projected on one PSD at the same time. The measurement errors of the x and y axial positions of the two-dimensional tracking system were less than 1% in the measuring range of 20 mm. The results demonstrate that multiple-laser spot position measurement technology can be employed in a two-dimensional tracking measurement system

Diabetes mellitus is associated with late-onset post-stroke depression.

Science.gov (United States)

Zhang, Yu; He, Ji-Rong; Liang, Huai-Bin; Lu, Wen-Jing; Yang, Guo-Yuan; Liu, Jian-Rong; Zeng, Li-Li

2017-10-15

To explore the associated factors of late-onset post-stroke depression (PSD). A total of 251 patients with acute ischemic stroke were recruited. The evaluation of depression was performed 2 weeks after ischemia. 206 patients showing no depression in 2 weeks were followed up. They were divided into late-onset PSD group and non-depressed group by clinical interview with Hamilton depression scale score 3 months after stroke. On the first day following hospitalization, the clinical data including age, gender, educational level and vascular risk factors were recorded. The severity, etiological subtype and location of stroke were evaluated. The inflammatory mediators, glucose and lipid levels were recorded on the day of admission. The association between clinical factors and late-onset PSD was explored by logistic regression analysis. The ROC analysis was performed to evaluate the predicting power of the clinical factors. 187 of 206 patients completed the assessment 3 months after stroke. 19 (10.16%) patients were diagnosed as late onset PSD. Diabetes mellitus was an independent risk factor for late-onset PSD (OR 2.675, p = 0.047). ROC analysis demonstrated that glucose and HbA1C could predict late-onset PSD with specificity of 84.4%. The sample of our study was small. The results should be further confirmed in a larger cohort of patients with acute ischemic stroke. The acute ischemic stroke patients with diabetes mellitus were more tendered to suffer late-onset PSD. Copyright © 2017 Elsevier B.V. All rights reserved.

A postsynaptic signaling pathway that may account for the cognitive defect due to IL1RAPL1 mutation

Czech Academy of Sciences Publication Activity Database

Pavlowski, A.; Gianfelice, A.; Pallotto, M.; Zanchi, A.; Vara, H.; Khelfaoui, M.; Valnegri, P.; Rezai, X.; Bassani, S.; Brambilla, D.; Kumpošt, Jiří; Blahoš, Jaroslav; Roux, M.J.; Humeau, Y.; Chelly, J.; Passafaro, M.; Giustetto, M.; Billuart, P.; Sala, C.

2010-01-01

Roč. 20, č. 2 (2010), s. 103-115 ISSN 0960-9822 R&D Projects: GA ČR GA303/08/1591 Institutional research plan: CEZ:AV0Z50520514 Keywords : synaptic plasticity * hippocampal neurons * PSD-95 Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 10.025, year: 2010

Investigation on the separability of slums by multi-aspect TerraSAR-X dual-co-polarized high resolution spotlight images based on the multi-scale evaluation of local distributions

Science.gov (United States)

Schmitt, Andreas; Sieg, Tobias; Wurm, Michael; Taubenböck, Hannes

2018-02-01

Following recent advances in distinguishing settlements vs. non-settlement areas from latest SAR data, the question arises whether a further automatic intra-urban delineation and characterization of different structural types is possible. This paper studies the appearance of the structural type ;slums; in high resolution SAR images. Geocoded Kennaugh elements are used as backscatter information and Schmittlet indices as descriptor of local texture. Three cities with a significant share of slums (Cape Town, Manila, Mumbai) are chosen as test sites. These are imaged by TerraSAR-X in the dual-co-polarized high resolution spotlight mode in any available aspect angle. Representative distributions are estimated and fused by a robust approach. Our observations identify a high similarity of slums throughout all three test sites. The derived similarity maps are validated with reference data sets from visual interpretation and ground truth. The final validation strategy is based on completeness and correctness versus other classes in relation to the similarity. High accuracies (up to 87%) in identifying morphologic slums are reached for Cape Town. For Manila (up to 60%) and Mumbai (up to 54%), the distinction is more difficult due to their complex structural configuration. Concluding, high resolution SAR data can be suitable to automatically trace potential locations of slums. Polarimetric information and the incidence angle seem to have a negligible impact on the results whereas the intensity patterns and the passing direction of the satellite are playing a key role. Hence, the combination of intensity images (brightness) acquired from ascending and descending orbits together with Schmittlet indices (spatial pattern) promises best results. The transfer from the automatically recognized physical similarity to the semantic interpretation remains challenging.

Study of Integrated USV/UUV Observation System Performance in Monterey Bay

Science.gov (United States)

2017-09-01

EMATT expendable mobile ASW training target MARS Monterey Accelerated Research System MBARI Monterey Bay Aquarium Research Institute PSD power ...Paula Travis, provided needed support as well. The Naval Postgraduate School faculty and staff are incredibly professional and knowledgeable . The...operation. 9 “The MARS observatory ‘science node’ (shown in orange) has eight ports, each of which can supply data and power connections for

E-dictionary Use under the Spotlight: Students' Use of Pocket ...

African Journals Online (AJOL)

This article reports on the utilisation of pocket electronic dictionaries (PEDs) for writing by learners of English at a Thai university. It aims to enrich the study of dictionary use behaviour by investigating, through the use of combined research methods, exactly what happens when students use PEDs for production.

Characteristic evaluation of a real-time silicon dosimeter and measurement of entrance surface dose at radiography

International Nuclear Information System (INIS)

Fujibuchi, Toshiou; Kato, Hideyuki; Hashimoto, Masatoshi; Abe, Yukinao; Kikawa, Takashi

2006-01-01

It is important to grasp how much radiation exposure has occurred through radiation diagnosis, in respect to patient explanations and radiation protection. In this examination, we used a patient skin dosimeter (PSD) that measures entrance surface dose (ESD) in real time using a fluoroscopy procedure. The PSD has the ability to display results beginning at 1 μGy. We focused our attention on the X-ray detectability of the PSD, and performed a representative evaluation with the X-ray equipment. We measured ESD under various radiographic parameters at our facility. Although the measurements were dependent on energy, we were able to measure ESD to within an accuracy of about a 5% error by putting a calibration value on energy. The PSD can measure ESD easily without requiring preparation. It is important to be aware of the exposure dose to the radiation staff, and the PSD is a very effective radiation dose-measuring tool when daily business is active. (author)

Neurotransmitters Drive Combinatorial Multistate Postsynaptic Density Networks

OpenAIRE

Coba, Marcelo P; Pocklington, Andrew J; Collins, Mark O; Kopanitsa, Maksym V; Uren, Rachel T; Swamy, Sajani; Croning, Mike D R; Choudhary, Jyoti S; Grant, Seth G N

2009-01-01

The mammalian postsynaptic density (PSD) comprises a complex collection of approximately 1100 proteins. Despite extensive knowledge of individual proteins, the overall organization of the PSD is poorly understood. Here, we define maps of molecular circuitry within the PSD based on phosphorylation of postsynaptic proteins. Activation of a single neurotransmitter receptor, the N-methyl-D-aspartate receptor (NMDAR), changed the phosphorylation status of 127 proteins. Stimulation of ionotropic an...

Different stress modalities result in distinct steroid hormone responses by male rats

Directory of Open Access Journals (Sweden)

M.L. Andersen

2004-06-01

Full Text Available Since both paradoxical sleep deprivation (PSD and stress alter male reproductive function, the purpose of the present study was to examine the influence of PSD and other stressors (restraint, electrical footshock, cold and forced swimming, N = 10 per group on steroid hormones in adult Wistar male rats. Rats were submitted to chronic stress for four days. The stressors (footshock, cold and forced swimming were applied twice a day, for periods of 1 h at 9:00 and 16:00 h. Restrained animals were maintained in plastic cylinders for 22 h/day whereas PSD was continuous. Hormone determination was measured by chemiluminescent enzyme immunoassay (testosterone, competitive immunoassay (progesterone and by radioimmunoassay (corticosterone, estradiol, estrone. The findings indicate that PSD (13.7 ng/dl, footshock (31.7 ng/dl and cold (35.2 ng/dl led to lower testosterone levels compared to the swimming (370.4 ng/dl and control (371.4 ng/dl groups. However, progesterone levels were elevated in the footshock (4.5 ng/ml and PSD (5.4 ng/ml groups compared to control (1.6 ng/ml, swimming (1.1 ng/ml, cold (2.3 ng/ml, and restrained (1.2 ng/ml animals. Estrone and estradiol levels were reduced in the PSD, footshock and restraint groups compared to the control, swimming and cold groups. A significant increase in corticosterone levels was found only in the PSD (299.8 ng/ml and footshock (169.6 ng/ml groups. These changes may be thought to be the full steroidal response to stress of significant intensity. Thus, the data suggest that different stress modalities result in distinct steroid hormone responses, with PSD and footshock being the most similar.

Fast convergent frequency-domain MIMO equalizer for few-mode fiber communication systems

Science.gov (United States)

He, Xuan; Weng, Yi; Wang, Junyi; Pan, Z.

2018-02-01

Space division multiplexing using few-mode fibers has been extensively explored to sustain the continuous traffic growth. In few-mode fiber optical systems, both spatial and polarization modes are exploited to transmit parallel channels, thus increasing the overall capacity. However, signals on spatial channels inevitably suffer from the intrinsic inter-modal coupling and large accumulated differential mode group delay (DMGD), which causes spatial modes de-multiplex even harder. Many research articles have demonstrated that frequency domain adaptive multi-input multi-output (MIMO) equalizer can effectively compensate the DMGD and demultiplex the spatial channels with digital signal processing (DSP). However, the large accumulated DMGD usually requires a large number of training blocks for the initial convergence of adaptive MIMO equalizers, which will decrease the overall system efficiency and even degrade the equalizer performance in fast-changing optical channels. Least mean square (LMS) algorithm is always used in MIMO equalization to dynamically demultiplex the spatial signals. We have proposed to use signal power spectral density (PSD) dependent method and noise PSD directed method to improve the convergence speed of adaptive frequency domain LMS algorithm. We also proposed frequency domain recursive least square (RLS) algorithm to further increase the convergence speed of MIMO equalizer at cost of greater hardware complexity. In this paper, we will compare the hardware complexity and convergence speed of signal PSD dependent and noise power directed algorithms against the conventional frequency domain LMS algorithm. In our numerical study of a three-mode 112 Gbit/s PDM-QPSK optical system with 3000 km transmission, the noise PSD directed and signal PSD dependent methods could improve the convergence speed by 48.3% and 36.1% respectively, at cost of 17.2% and 10.7% higher hardware complexity. We will also compare the frequency domain RLS algorithm against

Psychiatric Disorders and Psychopharmacologic Treatment as Risk Factors in Elective Fast-track Total Hip and Knee Arthroplasty

DEFF Research Database (Denmark)

Jørgensen, Christoffer C; Knop, Joachim; Nordentoft, Merete

2015-01-01

BACKGROUND: Psychiatric disorder (PsD) is rarely considered when evaluating perioperative risk factors. Studies on PsD are often limited by use of administrative coding, incomplete follow-up, and lack of preoperative data on psychopharmacological treatment. METHODS: A multicenter study with prosp......BACKGROUND: Psychiatric disorder (PsD) is rarely considered when evaluating perioperative risk factors. Studies on PsD are often limited by use of administrative coding, incomplete follow-up, and lack of preoperative data on psychopharmacological treatment. METHODS: A multicenter study...... inhibitors (SSRIs), 31.6% used other antidepressants, 8.5% used a combination, and 16.5% used antipsychotics. PsD was associated with increased risk of LOS more than 4 days (16.5 vs. 7.3%; odds ratio, 1.90; 95% CI, 1.52 to 2.37), regardless of treatment with SSRIs (2.19; 1.62 to 2.97), other antidepressants...... (2.24; 1.51 to 3.32 and 1.82; 1.27 to 2.61), and antipsychotics (1.85; 1.03 to 3.31, 30 days only). In PsD patients, pain (1.4%), postoperative anemia (1.1%), and pulmonary complications (1.1%) were the most frequent causes of LOS more than 4 days. Hip displacements (2.8%) and falls (1.9%) were...

Characterization and genetic mapping of a Photoperiod-sensitive dwarf 1 locus in rice (Oryza sativa L.).

Science.gov (United States)

Li, Riqing; Xia, Jixing; Xu, Yiwei; Zhao, Xiucai; Liu, Yao-Guang; Chen, Yuanling

2014-01-01

Plant height is an important agronomic trait for crop architecture and yield. Most known factors determining plant height function in gibberellin or brassinosteroid biosynthesis or signal transduction. Here, we report a japonica rice (Oryza sativa ssp. japonica) dominant dwarf mutant, Photoperiod-sensitive dwarf 1 (Psd1). The Psd1 mutant showed impaired cell division and elongation, and a severe dwarf phenotype under long-day conditions, but nearly normal growth in short-day. The plant height of Psd1 mutant could not be rescued by gibberellin or brassinosteroid treatment. Genetic analysis with R1 and F2 populations determined that Psd1 phenotype was controlled by a single dominant locus. Linkage analysis with 101 tall F2 plants grown in a long-day season, which were derived from a cross between Psd1 and an indica cultivar, located Psd1 locus on chromosome 1. Further fine-mapping with 1017 tall F2 plants determined this locus on an 11.5-kb region. Sequencing analysis of this region detected a mutation site in a gene encoding a putative lipid transfer protein; the mutation produces a truncated C-terminus of the protein. This study establishes the genetic foundation for understanding the molecular mechanisms regulating plant cell division and elongation mediated by interaction between genetic and environmental factors.

Multimodal Dispersion of Nanoparticles: A Comprehensive Evaluation of Size Distribution with 9 Size Measurement Methods.

Science.gov (United States)

Varenne, Fanny; Makky, Ali; Gaucher-Delmas, Mireille; Violleau, Frédéric; Vauthier, Christine

2016-05-01

Evaluation of particle size distribution (PSD) of multimodal dispersion of nanoparticles is a difficult task due to inherent limitations of size measurement methods. The present work reports the evaluation of PSD of a dispersion of poly(isobutylcyanoacrylate) nanoparticles decorated with dextran known as multimodal and developed as nanomedecine. The nine methods used were classified as batch particle i.e. Static Light Scattering (SLS) and Dynamic Light Scattering (DLS), single particle i.e. Electron Microscopy (EM), Atomic Force Microscopy (AFM), Tunable Resistive Pulse Sensing (TRPS) and Nanoparticle Tracking Analysis (NTA) and separative particle i.e. Asymmetrical Flow Field-Flow Fractionation coupled with DLS (AsFlFFF) size measurement methods. The multimodal dispersion was identified using AFM, TRPS and NTA and results were consistent with those provided with the method based on a separation step prior to on-line size measurements. None of the light scattering batch methods could reveal the complexity of the PSD of the dispersion. Difference between PSD obtained from all size measurement methods tested suggested that study of the PSD of multimodal dispersion required to analyze samples by at least one of the single size particle measurement method or a method that uses a separation step prior PSD measurement.

Tow plows could help Michigan save time and money on winter maintenance : research spotlight.

Science.gov (United States)

2016-11-01

As winter maintenance costs rise, MDOT is looking into innovative approaches to increase snow removal efficiency. As part of this effort, the department recently estimated the costs and benefits of incorporating tow plows into its equipment fleet. Re...

High resolution fast neutron spectrometry without time-of-flight

International Nuclear Information System (INIS)

Evans, A.E.; Brandenberger, J.D.

1978-01-01

Performance tests of a spectrometer tube of the type developed by Cuttler and Shalev show that the measurement of fast neutron spectra with this device can be made with an energy resolution previously obtainable only in large time-of-flight facilities. In preliminary tests, resolutions of 16.4 keV for thermal neutrons and 30.9 keV for 1-MeV neutrons were obtained. A broad-window pulse-shape discrimination (PSD) system is used to remove from pulse-height distributions most of the continua due to 3 He-recoil events, noise, and wall effect. Use of PSD improved the energy resolution to 12.9 keV for thermal neutrons and 29.2 keV for 1-MeV neutrons. The detector is a viable tool for neutron research at nominally equipped accelerator laboratories

Area Handbook Series: Chile: A Country Study

Science.gov (United States)

1982-05-01

Independent Popular Action (Acci6n Popular Independiente -API). By 1973 the PSD had withdrawn from the coalition, while a leftist splinter from the Christian...the Social Democratic Party (Partido Social Dem- ocratica - PSD); and Independent Popular Action (Acci6n Popular Independiente -API). By 1973 the PSD...powerful and politically sensitive post . Prats and the others served in these positions until March 1973. The departure of the military officers from the

Paradoxical sleep deprivation decreases serum testosterone and Leydig cells in male rats

Directory of Open Access Journals (Sweden)

Fitranto Arjadi

2014-04-01

Full Text Available Background Chronic stress increases glucocorticoid levels and accelerates reduction in Leydig cells functions and numbers. Chronic stress models in the working place comprise sleep deprivation, sedentary stress, and physical stress. The aim of this study was to evaluate the effect of various work stress models, such as stress from paradoxical sleep deprivation (PSD, immobilization, and footshock, on serum testosterone levels and number of Leydig cells in male albino rats. Methods This study was of experimental randomized post-test only with control group design using 24 male Wistar albino rats (Rattus norvegicus. The sample was divided into 4 groups: K1 (control, K2 (PSD, K3 (immobilization and K4 (footshock, receiving treatment for 25 days. Measured parameters were serum testosterone level and Leydig cell number. Analysis of variance (ANOVA was used for statistical analysis, followed by post hoc LSD. Results Mean serum testosterone levels (0.07 ± 0.08 ng/mL and Leydig cell numbers (4.22 ± l0.96 were lowest in the PSD stress model. Serum testosterone levels differed significantly between controls and PSD group (p=0.014, while there was a significant difference in numbers of Leydig cells between footshock stress and PSD (p=0.011 and between the three stress groups and controls (p=0.006. Conclusion This study demonstrated that PSD, immobilization and footshock stress significantly decreased serum testosterone levels and number of Leydig cells in male albino rats (Rattus norvegicus. The mechanism by which PSD affects serum testosterone is still unclear.

Postsynaptic density protein 95 in the striosome and matrix compartments of the human neostriatum.

Directory of Open Access Journals (Sweden)

Ryoma eMorigaki

2015-11-01

Full Text Available The human neostriatum consists of two functional subdivisions referred to as the striosome (patch and matrix compartments. The striosome-matrix dopamine systems play a central role in cortico-thalamo-basal ganglia circuits, and their involvement is thought to underlie the genesis of multiple movement and behavioral disorders, and of drug addiction. Human neuropathology also has shown that striosomes and matrix have differential vulnerability patterns in several striatal neurodegenerative diseases. Postsynaptic density protein 95 (PSD-95, also known as DLG4, is a major scaffolding protein in the postsynaptic densities of dendritic spines. PSD-95 is now known to negatively regulate not only N-methyl-D-aspartate glutamate signaling, but also dopamine D1 signals at sites of postsynaptic transmission. Accordingly, a neuroprotective role for PSD-95 against dopamine D1 receptor (D1R-mediated neurotoxicity in striatal neurodegeneration also has been suggested. Here, we used a highly sensitive immunohistochemistry technique to show that in the human neostriatum, PSD-95 is differentially concentrated in the striosome and matrix compartments, with a higher density of PSD-95 labeling in the matrix compartment than in the striosomes. This compartment-specific distribution of PSD-95 was strikingly complementary to that of D1R. In addition to the possible involvement of PSD-95-mediated synaptic function in compartment-specific dopamine signals, we suggest that the striosomes might be more susceptible to D1R-mediated neurotoxicity than the matrix compartment. This notion may provide new insight into the compartment-specific vulnerability of MSNs in striatal neurodegeneration.

CYLD, a deubiquitinase specific for lysine63-linked polyubiquitins, accumulates at the postsynaptic density in an activity-dependent manner

Energy Technology Data Exchange (ETDEWEB)

Dosemeci, Ayse, E-mail: dosemeca@mail.nih.gov [Laboratory of Neurobiology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 (United States); Thein, Soe; Yang, Yijung; Reese, Thomas S. [Laboratory of Neurobiology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 (United States); Tao-Cheng, Jung-Hwa [EM Facility, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 (United States)

2013-01-04

Highlights: Black-Right-Pointing-Pointer CYLD is a deubiquitinase specific for lysine63-linked polyubiquitins. Black-Right-Pointing-Pointer Presence of CYLD in PSDs is established by biochemistry and immunoEM. Black-Right-Pointing-Pointer CYLD accumulates on PSDs upon depolarization of neurons. Black-Right-Pointing-Pointer Accumulation of CYLD at PSDs may regulate trafficking/degradation of synaptic proteins. -- Abstract: Polyubiquitin chains on proteins flag them for distinct fates depending on the type of polyubiquitin linkage. While lysine48-linked polyubiquitination directs proteins to proteasomal degradation, lysine63-linked polyubiquitination promotes different protein trafficking and is involved in autophagy. Here we show that postsynaptic density (PSD) fractions from adult rat brain contain deubiquitinase activity that targets both lysine48 and lysine63-linked polyubiquitins. Comparison of PSD fractions with parent subcellular fractions by Western immunoblotting reveals that CYLD, a deubiquitinase specific for lysine63-linked polyubiquitins, is highly enriched in the PSD fraction. Electron microscopic examination of hippocampal neurons in culture under basal conditions shows immunogold label for CYLD at the PSD complex in approximately one in four synapses. Following depolarization by exposure to high K+, the proportion of CYLD-labeled PSDs as well as the labeling intensity of CYLD at the PSD increased by more than eighty percent, indicating that neuronal activity promotes accumulation of CYLD at the PSD. An increase in postsynaptic CYLD following activity would promote removal of lysine63-polyubiquitins from PSD proteins and thus could regulate their trafficking and prevent their autophagic degradation.

PSD permit compliance strategies

International Nuclear Information System (INIS)

Cassada, J.; Astruc, S.

1993-01-01

Old Dominion is a not-for-profit generation and transmission cooperative owned by and serving twelve member electric distribution cooperatives in Virginia, Maryland and Delaware. These member cooperatives purchase from Old Dominion all the electric power they supply to over 345,000 member consumers. In 1988, Old Dominion evaluated its long term power needs, and the fact that 300 Megawatts (MW) of base power would have to be replaced by the end of 1994. A power supply alternative study was conducted, and concluded that the interests of the cooperative members would best be served through the construction of a conventional pulverized coal-fired generating units. After comprehensive evaluation and negotiations, Old Dominion signed a contract in April, 1989 with the Consortium of Combustion Engineering, H. B. Zachry, Black ampersand Veatch and Westinghouse for the turnkey construction of a 393 MW coal-fired facility. The contract included an option to build a second twin unit. This option was exercised in August, 1989, when Virginia Power joined Old Dominion as 50% partners in the Clover Project. The partnership agreement stipulates that Old Dominion is responsible for the licensing and construction of the plant and Virginia Power will be responsible for operations

Survey on the spirilar flora of Lagomorphs

OpenAIRE

Revez, Joana Marreiros Cabrita

2010-01-01

Members of the genera Campylobacter and Helicobacter have been in the spotlight in recent decades because of their status as animals and/or humans pathogens, both confirmed and emerging, and because of their association with food-borne and zoonotic diseases. First observations of spiral shaped bacteria or Campylobacter-like organisms (CLO) date back to the end of the 19th century, however the lack of adequate isolation methods hampered further research. With the introduction of methods suc...

Advanced sensing with micro-optical whispering-gallery-mode resonators

CERN Document Server

Righini, Giancarlo C

2017-01-01

This Spotlight examines an increasingly popular class of optical sensors that comprises microresonators based on the propagation of whispering gallery modes (WGMs). Several 2D and 3D WGM microresonators have already proved their capabilities as general-purpose sensors (especially as biosensors), and they have potential applications outside of research laboratories. Topics include the fundamentals of WGM propagation, types and characterization of microresonators, microfabrication issues, categories of sensing (physical, chemical, and biological), and state of the art sensors.

Induktivní usuzování dětí ve věku 10 až 12 let v matematickém prostředí

OpenAIRE

Herman, Jan

2010-01-01

Inductive reasoning of 10-12 year old children in mathematical environment Formation of inductive inference is a complex process influenced by a number of diverse phenomena, whose study is at present moving to the spotlight of the community of psychologists. So far, conclusions of researches in this domain have been used in mathematical environment only very rarely, this despite the fact that inductive reasoning is crucial in many operations which are perceived as essential in development of ...

A review of online trust branding strategies of financial services industries in Malaysia and Australia

OpenAIRE

Tan, Teck Ming; Rasiah, Devinaga

2011-01-01

This study spotlighted on the financial services industry specifically in the creation of brand trust across online channel, which constructs a significant contribution to the under-researched area of online branding. Content analysis was performed on the web sites of top ten bank retailers in Malaysia and Australia. An analysis of the extent to which the retailers were using their web sites to provide online financial services and brand information provided a context for a more detailed anal...

Dosimetric performance and array assessment of plastic scintillation detectors for stereotactic radiosurgery quality assurance.

Science.gov (United States)

Gagnon, Jean-Christophe; Thériault, Dany; Guillot, Mathieu; Archambault, Louis; Beddar, Sam; Gingras, Luc; Beaulieu, Luc

2012-01-01

To compare the performance of plastic scintillation detectors (PSD) for quality assurance (QA) in stereotactic radiosurgery conditions to a microion-chamber (IC), Gafchromic EBT2 films, 60 008 shielded photon diode (SD) and unshielded diodes (UD), and assess a new 2D crosshair array prototype adapted to small field dosimetry. The PSD consists of a 1 mm diameter by 1 mm long scintillating fiber (BCF-60, Saint-Gobain, Inc.) coupled to a polymethyl-methacrylate optical fiber (Eska premier, Mitsubishi Rayon Co., Ltd., Tokyo, Japan). Output factors (S(c,p)) for apertures used in radiosurgery ranging from 4 to 40 mm in diameter have been measured. The PSD crosshair array (PSDCA) is a water equivalent device made up of 49 PSDs contained in a 1.63 cm radius area. Dose profiles measurements were taken for radiosurgery fields using the PSDCA and were compared to other dosimeters. Moreover, a typical stereotactic radiosurgery treatment using four noncoplanar arcs was delivered on a spherical phantom in which UD, IC, or PSD was placed. Using the Xknife planning system (Integra Radionics Burlington, MA), 15 Gy was prescribed at the isocenter, where each detector was positioned. Output Factors measured by the PSD have a mean difference of 1.3% with Gafchromic EBT2 when normalized to a 10 × 10 cm(2) field, and 1.0% when compared with UD measurements normalized to the 35 mm diameter cone. Dose profiles taken with the PSD crosshair array agreed with other single detectors dose profiles in spite of the presence of the 49 PSDs. Gamma values comparing 1D dose profiles obtained with PSD crosshair array with Gafchromic EBT2 and UD measured profiles shows 98.3% and 100.0%, respectively, of detector passing the gamma acceptance criteria of 0.3 mm and 2%. The dose measured by the PSD for a complete stereotactic radiosurgery treatment is comparable to the planned dose corrected for its SD-based S(c,p) within 1.4% and 0.7% for 5 and 35 mm diameter cone, respectively. Furthermore

Dosimetric performance and array assessment of plastic scintillation detectors for stereotactic radiosurgery quality assurance

Energy Technology Data Exchange (ETDEWEB)

Gagnon, Jean-Christophe; Theriault, Dany; Guillot, Mathieu; Archambault, Louis; Beddar, Sam; Gingras, Luc; Beaulieu, Luc [Departement de Physique, de Genie Physique et d' Optique, Universite Laval, Quebec, Quebec G1K 7P4 (Canada) and Departement de Radio-Oncologie, Hotel-Dieu de Quebec, Centre Hospitalier Universitaire de Quebec, Quebec G1R 2J6 (Canada); Departement de Radio-Oncologie, Hotel-Dieu de Quebec, Centre Hospitalier Universitaire de Quebec, Quebec G1R 2J6 (Canada); Departement de Physique, de Genie Physique et d' Optique, Universite Laval, Quebec, Quebec G1K 7P4 (Canada) and Departement de Radio-Oncologie, Hotel-Dieu de Quebec, Centre Hospitalier Universitaire de Quebec, Quebec G1R 2J6 (Canada); Department of Radiation Physics, Unit 94, University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030 (United States); Departement de Physique, de Genie Physique et d' Optique, Universite Laval, Quebec, Quebec G1K 7P4 (Canada) and Departement de Radio-Oncologie, Hotel-Dieu de Quebec, Centre Hospitalier Universitaire de Quebec, Quebec G1R 2J6 (Canada)

2012-01-15

Purpose: To compare the performance of plastic scintillation detectors (PSD) for quality assurance (QA) in stereotactic radiosurgery conditions to a microion-chamber (IC), Gafchromic EBT2 films, 60 008 shielded photon diode (SD) and unshielded diodes (UD), and assess a new 2D crosshair array prototype adapted to small field dosimetry. Methods: The PSD consists of a 1 mm diameter by 1 mm long scintillating fiber (BCF-60, Saint-Gobain, Inc.) coupled to a polymethyl-methacrylate optical fiber (Eska premier, Mitsubishi Rayon Co., Ltd., Tokyo, Japan). Output factors (S{sub c,p}) for apertures used in radiosurgery ranging from 4 to 40 mm in diameter have been measured. The PSD crosshair array (PSDCA) is a water equivalent device made up of 49 PSDs contained in a 1.63 cm radius area. Dose profiles measurements were taken for radiosurgery fields using the PSDCA and were compared to other dosimeters. Moreover, a typical stereotactic radiosurgery treatment using four noncoplanar arcs was delivered on a spherical phantom in which UD, IC, or PSD was placed. Using the Xknife planning system (Integra Radionics Burlington, MA), 15 Gy was prescribed at the isocenter, where each detector was positioned. Results: Output Factors measured by the PSD have a mean difference of 1.3% with Gafchromic EBT2 when normalized to a 10 x 10 cm{sup 2} field, and 1.0% when compared with UD measurements normalized to the 35 mm diameter cone. Dose profiles taken with the PSD crosshair array agreed with other single detectors dose profiles in spite of the presence of the 49 PSDs. Gamma values comparing 1D dose profiles obtained with PSD crosshair array with Gafchromic EBT2 and UD measured profiles shows 98.3% and 100.0%, respectively, of detector passing the gamma acceptance criteria of 0.3 mm and 2%. The dose measured by the PSD for a complete stereotactic radiosurgery treatment is comparable to the planned dose corrected for its SD-based S{sub c,p} within 1.4% and 0.7% for 5 and 35 mm diameter cone

Dosimetric performance and array assessment of plastic scintillation detectors for stereotactic radiosurgery quality assurance

International Nuclear Information System (INIS)

Gagnon, Jean-Christophe; Theriault, Dany; Guillot, Mathieu; Archambault, Louis; Beddar, Sam; Gingras, Luc; Beaulieu, Luc

2012-01-01

Purpose: To compare the performance of plastic scintillation detectors (PSD) for quality assurance (QA) in stereotactic radiosurgery conditions to a microion-chamber (IC), Gafchromic EBT2 films, 60 008 shielded photon diode (SD) and unshielded diodes (UD), and assess a new 2D crosshair array prototype adapted to small field dosimetry. Methods: The PSD consists of a 1 mm diameter by 1 mm long scintillating fiber (BCF-60, Saint-Gobain, Inc.) coupled to a polymethyl-methacrylate optical fiber (Eska premier, Mitsubishi Rayon Co., Ltd., Tokyo, Japan). Output factors (S c,p ) for apertures used in radiosurgery ranging from 4 to 40 mm in diameter have been measured. The PSD crosshair array (PSDCA) is a water equivalent device made up of 49 PSDs contained in a 1.63 cm radius area. Dose profiles measurements were taken for radiosurgery fields using the PSDCA and were compared to other dosimeters. Moreover, a typical stereotactic radiosurgery treatment using four noncoplanar arcs was delivered on a spherical phantom in which UD, IC, or PSD was placed. Using the Xknife planning system (Integra Radionics Burlington, MA), 15 Gy was prescribed at the isocenter, where each detector was positioned. Results: Output Factors measured by the PSD have a mean difference of 1.3% with Gafchromic EBT2 when normalized to a 10 x 10 cm 2 field, and 1.0% when compared with UD measurements normalized to the 35 mm diameter cone. Dose profiles taken with the PSD crosshair array agreed with other single detectors dose profiles in spite of the presence of the 49 PSDs. Gamma values comparing 1D dose profiles obtained with PSD crosshair array with Gafchromic EBT2 and UD measured profiles shows 98.3% and 100.0%, respectively, of detector passing the gamma acceptance criteria of 0.3 mm and 2%. The dose measured by the PSD for a complete stereotactic radiosurgery treatment is comparable to the planned dose corrected for its SD-based S c,p within 1.4% and 0.7% for 5 and 35 mm diameter cone, respectively

Particle size distribution control of Pt particles used for particle gun

Science.gov (United States)

Ichiji, M.; Akiba, H.; Nagao, H.; Hirasawa, I.

2017-07-01

The purpose of this study is particle size distribution (PSD) control of submicron sized Pt particles used for particle gun. In this report, simple reaction crystallization is conducted by mixing H2PtCl6 and ascorbic acid. Without the additive, obtained Pt particles have broad PSD and reproducibility of experiment is low. With seeding, Pt particles have narrow PSD and reproducibility improved. Additionally, mean particle diameter of 100-700 nm is controlled by changing seeding amount. Obtained particles are successfully characterized as Pt by XRD results. Moreover, XRD spectra indicate that obtained particles are polycrystals. These experimental results suggest that seeding consumed nucleation, as most nuclei attached on the seed surface. This mechanism virtually restricted nucleation to have narrow PSD can be obtained.

SU-G-TeP2-08: Evaluation of Plastic Scintillator Detector for Small Field Stereotactic Patient-Specific Quality Assurance

Energy Technology Data Exchange (ETDEWEB)

Qin, Y; Gardner, S; Huang, Y; Kim, J; Wen, N; Chetty, I [Henry Ford Health System, Detroit, MI (United States)

2016-06-15

Purpose: To evaluate the performance of a commercial plastic scintillator detector (PSD) for small-field stereotactic patient-specific quality assurance using flattening-filter-free (FFF) beams. Methods: A total of ten spherical targets (volume range:[0.03cc–2cc]) were planned using Dynamic Conformal Arc(DCA-10 plans) and Volumetric Modulated Arc Therapy(VMAT-10 plans) techniques in Eclipse(AAA v.11, 1mm dose calculation grid size). Additionally, 15 previously-treated cranial and spine SRS plans were evaluated (6 DCA, 9 VMAT, volume range:[0.04cc–119.02cc]). All measurements were acquired using Varian Edge equipped with HDMLC. Three detectors were used: PinPoint ion chamber (PTW;active volume 0.015cc), Exradin W1 PSD (Standard Imaging;active volume 0.002cc), and Gafchromic EBT3 film (Ashland). PinPoint and PSD were positioned perpendicular to beam axis in a Lucy phantom (Standard Imaging). Films were placed at isocenter in solid water. Calibration films were delivered for absolute dose analysis. Results: For large spherical targets(>1.5cc) with DCA, all detectors agreed within 1% of AAA calculations. As target volume decreased, PSD measured higher doses than AAA (maximum difference: 3.3% at 0.03cc target), while PinPoint chamber measured lower doses (maximum difference:-3.8% at 0.03cc target). Inter-detector differences between pinpoint and PSD increased with decreasing target size; differences>5% were observed for targets<0.09cc. Similar trends for inter-detector behavior were observed for clinical plans. For target sizes<0.08cc, PSD measured>5% higher dose than PinPoint chamber (maximum difference: 9.25% at 0.04cc target). Film demonstrated agreement of −0.19±1.47% with PSD for all spherical targets, and agreement within −0.98±2.25% for all 15 clinical targets. Unlike DCA, VMAT plans did not show improved AAA-to-detector agreements for large targets. Conclusion: For all targets, the PSD measurements agreed with film within 1.0%, on average. For small

76 FR 82234 - Amendments to Delegation of Authority Provisions in the Prevention of Significant Deterioration...

Science.gov (United States)

2011-12-30

...) program that would correct certain outdated language that currently limits EPA's ability to delegate the... consistency with the current Federal PSD regulatory requirements by allowing the EPA to delegate the PSD...

The effect of mechanical stress on lateral-effect position-sensitive detector characteristics

Energy Technology Data Exchange (ETDEWEB)

Andersson, H.A. [Department of Information Technology and Media, Mid-Sweden University, SE-85170 Sundsvall (Sweden)]. E-mail: Henrik.Andersson@miun.se; Mattsson, C.G. [Department of Information Technology and Media, Mid-Sweden University, SE-85170 Sundsvall (Sweden); Thungstroem, G. [Department of Information Technology and Media, Mid-Sweden University, SE-85170 Sundsvall (Sweden); Lundgren, A. [SiTek Electro Optics, Ogaerdesvaegen 13A 433 30 Partille (Sweden); Nilsson, H.-E. [Department of Information Technology and Media, Mid-Sweden University, SE-85170 Sundsvall (Sweden)

2006-07-01

Position-sensitive detectors (PSDs) are widely used in noncontact measurement systems. In order to minimize the size of such systems, interest has increased in mounting the PSD chip directly onto printed circuit boards (PCBs). Stress may be induced in the PSD because of the large differences in thermal expansion coefficients, as well as the long-term geometrical stability of the chip packaging. Mechanical stress has previously been shown to have an effect on the performance of semiconductors. The accuracy, or linearity, of a lateral effect PSD is largely dependent on the homogeneity of the resistive layer. Variations of the resistivity over the active area of the PSD will result in an uneven distribution of photo-generated current, and hence an error in the readout position. In this work experiments were performed to investigate the influence of anisotropic mechanical stress in terms of nonlinearity. PSD chips of 60x3 mm active area were subjected, respectively, to different amounts of compressive and tensile stress to determine the influence on the linearity.

Characterization of colloidal manganese hydroxylapatite: A potential magnetic resonance contrast agent

Science.gov (United States)

Dorshow, Richard B.; Kofi Adzamli, I.; Nosco, Dennis L.; Joslin, Frederick L.

1996-03-01

Particulate contrast agents for blood pool imaging need to be constructed with the appropriate particle size distribution (PSD), and need to be resistant to opsonization. Hence, the PSD of an aqueous colloidal suspension of polyethylene glycol (PEG)-stabilized manganese hydroxylapatite (potentially useful as a magnetic resonance contrast agent for blood pool imaging) has been investigated as a function of PEG concentration and molecular weight. At low PEG concentrations, dynamic light scattering (DLS) and sedimentation field flow fractionation measurements yield a broad PSD, with the largest particle diameters near 100nm. Flow field flow fractionation (FlFFF) measurements, however, yield a distinct population near 10nm, which is not readily detectable by the other two techniques. As the PEG concentration is increased, the PSD shifts toward the lower size population. At the highest PEG concentration employed, only particles of diameter 10nm remain, verified by both FlFFF and DLS. Thus, the search for an optimum PSD for blood pool imaging is facilitated by choice of PEG molecular weight and concentration, and by employing complementary use of light scattering and field flow fractionation techniques.

Age-Associated Changes in the Spectral and Statistical Parameters of Surface Electromyogram of Tibialis Anterior.

Science.gov (United States)

Siddiqi, Ariba; Arjunan, Sridhar Poosapadi; Kumar, Dinesh Kant

2016-01-01

Age-related neuromuscular change of Tibialis Anterior (TA) is a leading cause of muscle strength decline among the elderly. This study has established the baseline for age-associated changes in sEMG of TA at different levels of voluntary contraction. We have investigated the use of Gaussianity and maximal power of the power spectral density (PSD) as suitable features to identify age-associated changes in the surface electromyogram (sEMG). Eighteen younger (20-30 years) and 18 older (60-85 years) cohorts completed two trials of isometric dorsiflexion at four different force levels between 10% and 50% of the maximal voluntary contraction. Gaussianity and maximal power of the PSD of sEMG were determined. Results show a significant increase in sEMG's maximal power of the PSD and Gaussianity with increase in force for both cohorts. It was also observed that older cohorts had higher maximal power of the PSD and lower Gaussianity. These age-related differences observed in the PSD and Gaussianity could be due to motor unit remodelling. This can be useful for noninvasive tracking of age-associated neuromuscular changes.

Precise-spike-driven synaptic plasticity: learning hetero-association of spatiotemporal spike patterns.

Directory of Open Access Journals (Sweden)

Qiang Yu

Full Text Available A new learning rule (Precise-Spike-Driven (PSD Synaptic Plasticity is proposed for processing and memorizing spatiotemporal patterns. PSD is a supervised learning rule that is analytically derived from the traditional Widrow-Hoff rule and can be used to train neurons to associate an input spatiotemporal spike pattern with a desired spike train. Synaptic adaptation is driven by the error between the desired and the actual output spikes, with positive errors causing long-term potentiation and negative errors causing long-term depression. The amount of modification is proportional to an eligibility trace that is triggered by afferent spikes. The PSD rule is both computationally efficient and biologically plausible. The properties of this learning rule are investigated extensively through experimental simulations, including its learning performance, its generality to different neuron models, its robustness against noisy conditions, its memory capacity, and the effects of its learning parameters. Experimental results show that the PSD rule is capable of spatiotemporal pattern classification, and can even outperform a well studied benchmark algorithm with the proposed relative confidence criterion. The PSD rule is further validated on a practical example of an optical character recognition problem. The results again show that it can achieve a good recognition performance with a proper encoding. Finally, a detailed discussion is provided about the PSD rule and several related algorithms including tempotron, SPAN, Chronotron and ReSuMe.

[Two simple questions to diagnose post-stroke depression].

Science.gov (United States)

Nolte, C H; Müller-Nordhorn, J; Jungehülsing, G J; Rossnagel, K; Reich, A; Roll, S; Laumeier, I; Beerfelde, D; Willich, S N; Villringer, A

2006-05-01

Many patients develop a depression after having suffered a stroke. Such a Post-Stroke Depression (PSD) impairs rehabilitation and quality of life. PSD is underdiagnosed in spite of available treatment. Several questionnaires have been created to diagnose a PSD. But questionnaires have been considered cumbersome and time-consuming. The aim of this study was to find out whether two simple, standardised questions will identify those stroke patients, who have developed a PSD. The two case-finding questions and the Beck Depression Inventory (BDI) were sent to patients of the Berlin Acute Stroke Study (BASS) four years after their stroke. Incomplete questionnaires were complemented via mail or telephone. Severity of depression was assessed by means of BDI. Out of 211 patients, 199 responded to the questionnaire (94 %). 193 questionnaires were complete (97 %). Forty-two patients affirmed both case-finding questions (22 %). Compared to patients, who did not affirm both questions, these patients had a higher BDI score (19 +/- 8 vs. 7 +/- 5; p two questions were 89 % and 90 %, respectively. The positive and negative predictive value were 60 % and 98 % respectively. The number of confirmed questions (0, 1, 2) correlated well with the BDI score (r (2) = 0.67, p Two standardized questions can identify patients with PSD for further diagnostic evaluation and therapy. Diagnosis of PSD might be facilitated by using them as screening instrument.

Efficacy of Cognitive Rehabilitation Therapy on Poststroke Depression among Survivors of First Stroke Attack in Ibadan, Nigeria.

Science.gov (United States)

Olukolade, Olugbemi; Osinowo, Helen O

2017-01-01

Poststroke depression (PSD) is a common complication after stroke. There is no adequate treatment for PSD. This study examined efficacy of cognitive rehabilitation therapy (CRT) in the treatment of PSD among stroke survivors. An experimental design, 30 participants with poststroke depression were randomly assigned into 3 groups of cognitive rehabilitation therapy (CRT), psychoeducation (PE), and the control group (CG). CRT consisted of nine sessions with three-phased sessions focusing on activity stimulation, negative thoughts, and people contacts, PE consisted of nine sessions focusing on knowledge on stroke and poststroke depression, and the CG group was on the waiting list. The BDI scale was used for assessing PSD at posttest. There was a significant difference in the efficacy of CRT, PE, and the CG on PSD, with CRT-CG mean difference of -9.4 ± 3.11 and PE-CG 1.0 ± 3.83. Furthermore, stress was not a confounding variable on the efficacy of CRT. The type of therapy significantly influenced PSD at posttest, with the CRT having greater mean reduction to CG (-11.1 ± 3.1) than PE to the CG (3.0 ± 3.8). Cognitive rehabilitation therapy significantly reduced poststroke depression. Hence, it should be integrated as an adjunct treatment of poststroke depression.

Technical Note: Out-of-field dose measurement at near surface with plastic scintillator detector.

Science.gov (United States)

Bourgouin, Alexandra; Varfalvy, Nicolas; Archambault, Louis

2016-09-08

Out-of-field dose depends on multiple factors, making peripheral dosimetry com-plex. Only a few dosimeters have the required features for measuring peripheral dose. Plastic scintillator dosimeters (PSDs) offer numerous dosimetric advantages as required for out-of-field dosimetry. The purpose of this study is to determine the potential of using PSD as a surface peripheral dosimeter. Measurements were performed with a parallel-plate ion chamber, a small volume ion chamber, and with a PSD. Lateral-dose measurements (LDM) at 0.5 cm depth and depth-dose curve (PDD) were made and compared to the dose calculation provided by a treatment planning system (TPS). This study shows that a PSD can measure a dose as low as 0.51 ± 0.17 cGy for photon beam and 0.58 ± 0.20 cGy for electron beam with a difference of 0.2 and 0.1 cGy compared to a parallel-plate ion chamber. This study demonstrates the potential of using PSD as an out-of-field dosimeter since measure-ments with PSD avoid averaging over a too-large depth, at 1 mm diameter, and can make precise measurement at very low dose. Also, electronic equilibrium is easier to reach with PSD due to its small sensitive volume and its water equivalence. © 2016 The Authors.

Osseointegration of titanium implants functionalised with phosphoserine-tethered poly(epsilon-lysine) dendrons: a comparative study with traditional surface treatments in sheep.

Science.gov (United States)

Stübinger, Stefan; Nuss, Katja; Bürki, Alexander; Mosch, Isabel; le Sidler, Miché; Meikle, Steve T; von Rechenberg, Brigitte; Santin, Matteo

2015-02-01

The aim of this study was to analyse the osseointegrative potential of phosphoserine-tethered dendrons when applied as surface functionalisation molecules on titanium implants in a sheep model after 2 and 8 weeks of implantation. Uncoated and dendron-coated implants were implanted in six sheep. Sandblasted and etched (SE) or porous additive manufactured (AM) implants with and without additional dendron functionalisation (SE-PSD; AM-PSD) were placed in the pelvic bone. Three implants per group were examined histologically and six implants were tested biomechanically. After 2 and 8 weeks the bone-to-implant contact (BIC) total values of SE implants (43.7±12.2; 53.3±9.0%) and SE-PSD (46.7±4.5; 61.7±4.9%) as well as AM implants (20.49±5.1; 43.9±9.7%) and AM-PSD implants (19.7±3.5; 48.3±15.6%) showed no statistically significant differences. For SE-PSD and AM-PSD a separate analysis of only the cancellous BIC demonstrated a statistically significant difference after 2 and 8 weeks. Biomechanical findings proved the overall increased stability of the porous implants after 8 weeks. Overall, the great effect of implant macro design on osseointegration was further supported by additional phosphoserine-tethered dendrons for SE and AM implants.

Precise-spike-driven synaptic plasticity: learning hetero-association of spatiotemporal spike patterns.

Science.gov (United States)

Yu, Qiang; Tang, Huajin; Tan, Kay Chen; Li, Haizhou

2013-01-01

A new learning rule (Precise-Spike-Driven (PSD) Synaptic Plasticity) is proposed for processing and memorizing spatiotemporal patterns. PSD is a supervised learning rule that is analytically derived from the traditional Widrow-Hoff rule and can be used to train neurons to associate an input spatiotemporal spike pattern with a desired spike train. Synaptic adaptation is driven by the error between the desired and the actual output spikes, with positive errors causing long-term potentiation and negative errors causing long-term depression. The amount of modification is proportional to an eligibility trace that is triggered by afferent spikes. The PSD rule is both computationally efficient and biologically plausible. The properties of this learning rule are investigated extensively through experimental simulations, including its learning performance, its generality to different neuron models, its robustness against noisy conditions, its memory capacity, and the effects of its learning parameters. Experimental results show that the PSD rule is capable of spatiotemporal pattern classification, and can even outperform a well studied benchmark algorithm with the proposed relative confidence criterion. The PSD rule is further validated on a practical example of an optical character recognition problem. The results again show that it can achieve a good recognition performance with a proper encoding. Finally, a detailed discussion is provided about the PSD rule and several related algorithms including tempotron, SPAN, Chronotron and ReSuMe.

E-book lending in digital libraries: systematic review

Directory of Open Access Journals (Sweden)

Mehdi Alipour-Hafezi

2016-12-01

Full Text Available The purpose of this study is systematic review of e-book lending in digital libraries in order to identify the status of researches in e-book lending, exist research gaps, and their research methods. In this way, systematic review is used for study. Searching in databases in three steps finally showed 36 research resources to be studied. Findings demonstrate that researches on e-book lending are in progress and at the future this domain will be in the spotlight. Also findings showed that subjects such as e-book lending, business models and status of laws in e-book lending are the main fields that need more researches. Moreover study on research methods showed that most of the researches had done by quantitative approach and survey method.

Skills Decay in Military Medical Training: A Meta-synthesis of Research Outcomes.

Science.gov (United States)

Linde, Amber S; Caridha, Jona; Kunkler, Kevin J

2018-01-01

In fiscal year 2012, the Medical Simulation and Information Sciences Research Program released two Skills Decay (SD) research program announcements (PAs) under the Medical Readiness Initiative entitled "Medical Practice Initiative Breadth of Medical Practice & Disease Frequency Exposure (MPI-BMP)" and the "Medical Practice Initiative Procedural Skill Decay and Maintenance (MPI-PSD)." The Office of Naval Research also released a PA entitled "Medical Modeling and Simulation (MM&S) for Military Training and Education." A total investment of $12 M was made. This article provides a meta-synthesis of the Skills Decay research conducted under these efforts. The MSIRRP Medical Simulation Portfolio collected, reviewed, and analyzed the final reports of the Skills Decay research efforts from the three PAs. This paper provides a meta-synthesis of the outcomes of those studies. Focus of this study was to determine if the anticipated goals of the Skills Decay PAs were met as well as to provide a summary of lessons learned to the research community. Fourteen research questions posed by the PAs were structured into four main goals: (1) Skills Decay identification, (2) creation/validity of Skills Decay tools and feasibility and viability of data extraction project, (3) refreshment training to prevent or alleviate Skills Decay project, and (4) Skills Decay education content. Using a combination of training styles, choosing variables known to have Skills Decay predication value, and developing better ways of mining available data that can, in turn, provide feedback to training needs, it is possible for accurate Skills Decay models to be developed. These technologies have the ability not only capture the learner's reaction during the simulation, but to capture the simulation outcomes to predict a medical professional's level of experience and background. Lessons learned from the investments made by the government are extremely important in order to ensure that the outcomes of the

Data acquisition system for linear position sensitive detector based neutron diffractometer

International Nuclear Information System (INIS)

Pande, S.S.; Borkar, S.P.; Behere, A.; Prafulla, S.; Srivastava, V.D.; Mukhopadhyaya, P.K.; Ghodgaonkar, M.D.; Kataria, S.K.

2003-03-01

This data acquisition system is developed to serve the requirements of various linear 1PSD based neutron diffractometers. A neutron diffractometer uses a neutron beam as a probe to study the crystallographic properties of materials. Presently two multi-PSD and two single-PSD diffractometers are commissioned and a few more are being installed in Dhruva. This data acquisition system is installed at each of these - diffractometers. Different requirements of individual diffractometers were studied and reconciled to design a single data acquisition system, which can be easily configured or customized for individual setups. The charge division in a linear PSD is converted to a position output with the help of an RDC (Ratio ADC). The ftont-end electronics, which consist of preamplifiers and shaping amplifiers, provide an interface between a PSD and an RDC. A PC add-on card is designed around a Transputer. It can interface 16 RDCs, a few motor controls and on/off controls. Data acquisition and other controls are implemented in the Transputer program. A front-end Windows98 application merges the raw data of different RDCs to obtain the equiangular data. Through software the data acquisition system can be configured for diffetent diffractometers. Commercially available hardware is also integrated as,a part of the data acquisition system in some of the setups. The data acquisition system is working reliably as a part of two single PSD and two multi-PSD diffractometers. It can handle data rates upto 15 K/Sec without any loss of counts. It has played a significant role in providing improved throughput and utilization ofvarious diffractometers. The'data acquisition system and its different applications are presented in this report. (author)

A feasibility study of agricultural and sewage biomass as biochar, bioenergy and biocomposite feedstock: Production, characterization and potential applications

International Nuclear Information System (INIS)

Srinivasan, Prakash; Sarmah, Ajit K.; Smernik, Ron; Das, Oisik; Farid, Mohammed; Gao, Wei

2015-01-01

In this study, we pyrolysed six waste derived biomass: pine sawdust (PSD), paunch grass (PG), broiler litter (BL), sewage sludge (SS), dewatered pond sludge (DWP), and dissolved air-floatation sludge (DAF) into biochar. Biochars were characterized using scanning electron microscopy, energy dispersive X-ray spectrometry, X-ray diffraction, Fourier transform infrared spectroscopy, inductively-coupled plasma mass spectrometry, 13 C-solid-state nuclear magnetic resonance spectroscopy, and X-ray photoelectron spectroscopy to evaluate their feasibility for potential agronomic and environmental applications. Syngas produced during the pyrolysis process was also analyzed to determine the energy values. Results show that PSD biochar has the utmost potential for carbon sequestration and contaminant remediation due to its high surface area, aromaticity and carbon content. Additionally given its low ash content, PSD biochar could also potentially be used as filler in wood plastic biocomposites. Low levels of heavy metals (Cr, Cu, Zn, As, Cd, Hg, and Pb) in all biochars suggest that biochars are also applicable for land application according to the United States Environmental Protection Agency regulation 40 CFR part 503. The composition of syngas evolved during the pyrolysis of feedstocks showed little difference in the calorific values, ranging from 12–16 MJ/dsm with PSD having the maximum calorific value of 16 MJ/dsm. - Highlights: • PSD biochar was found to have the highest surface, carbon content and lowest ash content. • PSD biochar is suitable for carbon sequestration, remediation and biocomposite construction. • Syngas from PSD and PG pyrolysis yielded syngas having highest calorific values (15-16 MJ/dsm). • BL, PG and SS derived biochars have potential as liming agents due to their high ash content

A feasibility study of agricultural and sewage biomass as biochar, bioenergy and biocomposite feedstock: Production, characterization and potential applications

Energy Technology Data Exchange (ETDEWEB)

Srinivasan, Prakash [Department of Civil & Environmental Engineering, Faculty of Engineering, The University of Auckland, Private Bag 92019, Auckland (New Zealand); Sarmah, Ajit K., E-mail: a.sarmah@auckland.ac.nz [Department of Civil & Environmental Engineering, Faculty of Engineering, The University of Auckland, Private Bag 92019, Auckland (New Zealand); Smernik, Ron [School of Earth and Environmental Sciences, The University of Adelaide, Adelaide 5005 (Australia); Das, Oisik [Department of Civil & Environmental Engineering, Faculty of Engineering, The University of Auckland, Private Bag 92019, Auckland (New Zealand); Farid, Mohammed; Gao, Wei [Department of Chemical and Materials Engineering, Faculty of Engineering, The University of Auckland, 20 Symonds Street, Auckland (New Zealand)

2015-04-15

In this study, we pyrolysed six waste derived biomass: pine sawdust (PSD), paunch grass (PG), broiler litter (BL), sewage sludge (SS), dewatered pond sludge (DWP), and dissolved air-floatation sludge (DAF) into biochar. Biochars were characterized using scanning electron microscopy, energy dispersive X-ray spectrometry, X-ray diffraction, Fourier transform infrared spectroscopy, inductively-coupled plasma mass spectrometry, {sup 13}C-solid-state nuclear magnetic resonance spectroscopy, and X-ray photoelectron spectroscopy to evaluate their feasibility for potential agronomic and environmental applications. Syngas produced during the pyrolysis process was also analyzed to determine the energy values. Results show that PSD biochar has the utmost potential for carbon sequestration and contaminant remediation due to its high surface area, aromaticity and carbon content. Additionally given its low ash content, PSD biochar could also potentially be used as filler in wood plastic biocomposites. Low levels of heavy metals (Cr, Cu, Zn, As, Cd, Hg, and Pb) in all biochars suggest that biochars are also applicable for land application according to the United States Environmental Protection Agency regulation 40 CFR part 503. The composition of syngas evolved during the pyrolysis of feedstocks showed little difference in the calorific values, ranging from 12–16 MJ/dsm with PSD having the maximum calorific value of 16 MJ/dsm. - Highlights: • PSD biochar was found to have the highest surface, carbon content and lowest ash content. • PSD biochar is suitable for carbon sequestration, remediation and biocomposite construction. • Syngas from PSD and PG pyrolysis yielded syngas having highest calorific values (15-16 MJ/dsm). • BL, PG and SS derived biochars have potential as liming agents due to their high ash content.

Small angle neutron scattering. Report of a coordinated research project 2000-2003

International Nuclear Information System (INIS)

2006-03-01

Small angle neutron scattering (SANS) is a powerful technique for studying macro structures like polymers, precipitates in metallurgical specimens, biological molecules, micelles and magnetic systems like ferrofluids. Neutron scattering has an advantage over X ray scattering (XSAXS) due to selective absorption and scattering cross section of neutrons across the periodic table. It is possible to develop and use a SANS instrument even with a medium flux reactor. The present CRP was aimed at the development of components like collimators, monochromators, position sensitive detectors (PSD) etc. for improving the throughput of the instrument and foster the effective utilization of research reactors, as well as to provide a link between developing and developed facilities. The CRP was launched with the first research coordination meeting (RCM) in 2000 to refine the project proposals and define the action plans and partnerships. There were eight research contracts and four research agreements. Good partnerships were established between various participants with collaborations among participants from various countries including those from developing and developed countries. The progress of the individual projects and team work under the CRP was evaluated and discussed during the second RCM and the action plan for the final phase was formulated. The results of the work done under the CRP were then reviewed in the final RCM held in Vienna, December 2003. This publication presents the results of the work carried out by the participants under the CRP at their respective institutions. The information will be useful for the users and operators of research reactors in developing an instrument and building collaborations for capacity building. The development of collimators, detector assemblies, utilization of the SANS for microstructural characterization of advanced materials , development and design of a ultra small angle neutron scattering (USANS) and proposals for a new SANS

Paid sick days and stay-at-home behavior for influenza

OpenAIRE

Piper, Kaitlin; Youk, Ada; James, A. Everette; Kumar, Supriya

2017-01-01

Access to paid sick days (PSD) differs by workplace size, race/ethnicity, gender, and income in the United States. It is not known to what extent decisions to stay home from work when sick with infectious illnesses such as influenza depend on PSD access, and whether access impacts certain demographic groups more than others. We examined demographic and workplace characteristics (including access to PSD) associated with employees' decisions to stay home from work for their own or a child's ill...

Paid sick days and stay-at-home behavior for influenza.

Directory of Open Access Journals (Sweden)

Kaitlin Piper

Full Text Available Access to paid sick days (PSD differs by workplace size, race/ethnicity, gender, and income in the United States. It is not known to what extent decisions to stay home from work when sick with infectious illnesses such as influenza depend on PSD access, and whether access impacts certain demographic groups more than others. We examined demographic and workplace characteristics (including access to PSD associated with employees' decisions to stay home from work for their own or a child's illness. Linking the 2009 Medical Expenditure Panel Survey (MEPS consolidated data file to the medical conditions file, we used multivariate Poisson regression models with robust variance estimates to identify factors associated with missed work for an employee's own or a child's illness/injury, influenza-like-illness (ILI, and influenza. Controlling for gender, race/ethnicity, education, and income, access to PSD was associated with a higher probability of staying home for an employee's own illness/injury, ILI, or influenza, and for a child's illness/injury. Hispanic ethnicity was associated with a lower prevalence of staying home for the employee's own or a child's illness compared to non-Hispanic Whites. Access to PSD was associated with a significantly greater increase in the probability of staying home among Hispanics than among non-Hispanic Whites. Women had a significantly higher probability of staying home for their child's illness compared to men, suggesting that women remain the primary caregivers for ill children. Our results indicate that PSD access is important to encourage employees to stay home from work when sick with ILI or influenza. Also, PSD access may be important to enable stay-at-home behavior among Hispanics. We conclude that access to PSD is likely to reduce the spread of disease in workplaces by increasing the rate at which sick employees stay home from work, and reduce the economic burden of staying home on minorities, women, and

Simulation study of effects of initial particle size distribution on dissolution

International Nuclear Information System (INIS)

Wang, G.; Xu, D.S.; Ma, N.; Zhou, N.; Payton, E.J.; Yang, R.; Mills, M.J.; Wang, Y.

2009-01-01

Dissolution kinetics of γ' particles in binary Ni-Al alloys with different initial particle size distributions (PSD) is studied using a three-dimensional (3D) quantitative phase field model. By linking model inputs directly to thermodynamic and atomic mobility databases, microstructural evolution during dissolution is simulated in real time and length scales. The model is first validated against analytical solution for dissolution of a single γ' particle in 1D and numerical solution in 3D before it is applied to investigate the effects of initial PSD on dissolution kinetics. Four different types of PSD, uniform, normal, log-normal and bimodal, are considered. The simulation results show that the volume fraction of γ' particles decreases exponentially with time, while the temporal evolution of average particle size depends strongly on the initial PSD

Analytical Model for Passing Sight Distance Design Criteria of Two-Lane Roads in Sri Lanka

Directory of Open Access Journals (Sweden)

Mampearachchi W. K.

2018-03-01

Full Text Available For a safe overtaking manoeuvre on two-lane highways, drivers need a sufficient sight distance along the roadway, but it depends on the traffic environment. To provide an adequate Passing Sight Distance (PSD, a number of models have been proposed since the initial model introduced by American Association of State Highways and Transport Officials (AASHTO in 1954. It is a current design practice in Sri Lanka as well, however, not validated for local traffic conditions. This paper will present an alternative PSD model and an evaluation of AASHTO model for national highway design. Experiment was based on GPS data collection. In conclusion, PSD demand was satisfied by AASHTO PSD under mix traffic conditions, but not the safety concerns for speeds greater than 80 km/h, while alternative model successful for all speeds.

Depression following intracerebral hemorrhage and the evaluation of cerebral blood flow by single photon emission tomography

International Nuclear Information System (INIS)

Masada, Tetsuya; Makabe, Tetsuo; Kunishio, Katsuzo; Matsumoto, Akira

2007-01-01

The authors studied patients who presented depression and apathy following intracerebral hemorrhage (ICH). Twelve patients who were admitted in our hospital were divided into two groups according to the presence of post-stroke depression (PSD). Five patients with PSD are in group A, and another seven patients without PSD are in group B. Zung-self depression scale (SDS) and apathy scale were used for screening of depression and apathy. PSD was recognized in 5 (42%) of patients following ICH. Single photon emission tomography (SPECT) suggested the reduction of cerebral blood flow (CBF) in the frontal lobe in all patients of the group A (100%), whereas only 29% of patients of the group B. The reduction of CBF in the frontal lobe might be involved in the mechanism of depression following ICH in subacute stage. (author)

Recent developments in plastic scintillators with pulse shape discrimination

Science.gov (United States)

Zaitseva, N. P.; Glenn, A. M.; Mabe, A. N.; Carman, M. L.; Hurlbut, C. R.; Inman, J. W.; Payne, S. A.

2018-05-01

The paper reports results of studies conducted to improve scintillation performance of plastic scintillators capable of neutron/gamma pulse-shape discrimination (PSD). Compositional modifications made with the polymer matrix improved physical stability, allowing for increased loads of the primary dye that, in combination with selected secondary dyes, provided enhanced PSD especially important for the lower energy ranges. Additional measurements were made with a newly-introduced PSD plastic EJ-276, that replaces the first commercially produced EJ-299. Comparative studies conducted with the new materials and EJ-309 liquids at large scale (up to 10 cm) show that current plastics may provide scintillation and PSD performance sufficient for the replacement of liquid scintillators. Comparison to stilbene single crystals compliments the information about the status of the solid-state materials recently developed for fast neutron detection applications.

From man to mouse to cell ... and back again

International Nuclear Information System (INIS)

Del Guerra, Alberto; Belcari, Nicola

2007-01-01

Molecular imaging is an emerging field of research for the investigation of biological processes occurring at cellular level. This new field could help the understanding of human diseases by studying animal models. To accomplish this ambitious program, the development of novel high-performance imaging instruments such as small animal PET holds a fundamental role. This paper reports on the present state of the art in small animal PET scanners together with a spotlight view on future technologies for next generation instruments

CLOUD COMPUTING SECURITY ISSUES

OpenAIRE

Florin OGIGAU-NEAMTIU

2012-01-01

The term “cloud computing” has been in the spotlights of IT specialists the last years because of its potential to transform this industry. The promised benefits have determined companies to invest great sums of money in researching and developing this domain and great steps have been made towards implementing this technology. Managers have traditionally viewed IT as difficult and expensive and the promise of cloud computing leads many to think that IT will now be easy and cheap. The reality ...

Cloud security - An approach with modern cryptographic solutions

OpenAIRE

Kostadinovska, Ivana

2016-01-01

The term “cloud computing” has been in the spotlights of IT specialists due to its potential of transforming computer industry. Unfortunately, there are still some challenges to be resolved and the security aspects in the cloud based computing environment remain at the core of interest. The goal of our work is to identify the main security issues of cloud computing and to present approaches to secure clouds. Our research also focuses on data and storage security layers. As a result, we f...

COMPARATIVE ANALYSIS ON PERFORMANCE OF POWER CONVERTERSFOR MPPT USING PAO TECHNIQUE

OpenAIRE

Dr. S. Rajeswari*

2017-01-01

This research work is mainly spotlight to identify a suitable power converter for tracking the Maximum Power Point, an analysis of MPPT based power converters has been carried out in this work. A PV system is a non-linear power source due to the variations in the climatic conditions, hence tracking the maximum power point is difficult. It mainly explains about the PAO algorithm based MPPT method to track the maximum power. It also discuss about different types of conventional power converters...

Gender, media, and mixed martial arts in Poland: the case of Joanna Jędrzejczyk

OpenAIRE

Jakubowska, H; Channon, A; Matthews, CR

2016-01-01

Recent growth in the media visibility of female combat sport athletes has offered a compelling site for research on gender and sport media, as women in deeply masculinized sports have been increasingly placed in the public spotlight. While scholars in the Anglophone West have offered analyses of the media framing of this phenomenon, little work has been done outside these cultural contexts. Thus, in this paper we offer a qualitative exploration of how Joanna Jędrzejczyk, a Polish champion of ...

Sexual Harassment Prevention Policies at Japanese Universities

OpenAIRE

Creaser, Fiona

2009-01-01

In recent years, an accumulation of Japanese research about sexual harassment and a number of very public court cases involving prominent public figures placed the issue of sexual harassment in the media spotlight. Japan was forced to recognise sexual harassment as a national problem, and not an issue, which was confined to the Western world. In April 1999, the Japanese government realised the need to amend existing laws to include sexual harassment under article twenty-one of the Equal Oppor...

The Greater Impact of the Lhc:. What's in it for the Rest of the World?

Science.gov (United States)

Goldfarb, Steven

2012-08-01

All with any fundamental scientific endeavour, the true and enduring impact of the LHC physics program will not be measured in our lifetime. Rather, generations of future achievementi will follow from the combination of scientific knowledge and methods born from the research. The unprecedented size, scope and innovative nature of the LHC experiments, however, are already leaving a broad and significant impact on our society. A few of the more impressive, far-reaching, and amusing examples of these contributions are presented in this document. What remains is the task of communicating this progress to those who support it; that is, the rest of the world. Coordinated efforts by the outreach and educational programs of CERN and the experiments, coupled with a significant increase in media coverage, have succeeded to put the spotlight on the LHC. In addition, the rapidly growing popularity of social media bas provided these programs with new tools to focus this spotlight on the benefits of our work. I present means to use these tools effectively as we enter a new era of public scientific communication based on dialogue and discussion.

Measurement of reactor parameters of the 'Nora' reactor by noise analysis method - power spectral density

International Nuclear Information System (INIS)

Jovanovic, S.; Stormark, E.

1966-01-01

Measurements of reactor parameters the Nora reactor by Power Spectral Density (PSD) method are described. In case of critical reactor this method was applied for direct measurement of β/l ratio, β is the effective yield of delayed neutrons and l is the neutron lifetime. In case of subcritical reactor values of α+β-ρ/l were measured, ρ is the negative reactivity. Out coming PSD was measured by a filter or by ISAC. PSD was registered by ISAC as well as the auto-correlation function [sr

Spotlight: Bosnia and Herzegovina.

Science.gov (United States)

1998-05-01

This article discusses the demographic outcomes of the end of the civil war in Bosnia and Herzegovina. The war ended with the creation of the Bosnian Serb Republic and the Muslim-Croat Federation. In mid-1998, the population was 3.9 million. The population is smaller than it was before 1991, when Slovenia and Croatia separated from Yugoslavia. Many highly educated people left. Unemployment is an estimated 65-75%. Almost 500,000 soldiers must adjust to being civilians. In 1992, Muslims were 38% of total population, and Croats were 22% of total population. Muslims and Croats are now minorities in the Muslim-Croat Federation. The Serbs, who were 40% of the total population, led a civil war that was motivated by the desire for a Serb Republic. The Serbian "ethnic cleansing" created many thousands of refugees. Since the late 1995 Dayton Accord, about 400,000 refugees and displaced persons have returned to their prewar homes. Muslim-Croat Federation areas have received many refugees and have agreed to participate in the UN High Commissioner for Refugees' "open cities" project. About 1.5 million people are still scattered across Bosnia, Croatia, Yugoslavia, and Western Europe. Refugees are guaranteed under the Dayton Accord the right to return to their homes. However, returning means facing the dangers of land mines and other explosives in rural areas and being stoned along major roadways. Travelers rely on a few selected roads. Buses are considered a safe mode of transportation. The Serb Republic still defies the Dayton Accord, opposes the return of minorities, and enforces ethnic separation.

Spotlight. China. Part II.

Science.gov (United States)

Brophy, G

1989-04-01

China's 1-child policy was promulgated in 1979. Those couples who pledged to have 1 child could receive monetary bonuses, preferential treatment for housing, plot and grain allocation, health care, education, and job opportunities. The precise value of the package varied substantially. By 1981 47.3% of births were 1st births; in 1970, 21% were 1st births. Couples' renouncement of the 1-child pledge varied by province from less than 5% to 34%; 12.5% of holders who had had a girl renounced their pledge, compared to 6.7% who had had a boy. Despite a 1950 law designed to improve women's status,inequalities persist, and privileges accorded to 1-child certificate children, who are more likely to be male, may inadvertently perpetuate inequality. A provision of the 1980 Marriage Law making daughters as well as sons responsible for old age support and the development of handicraft and sideline occupations in rural areas may increase perception of daughters as economic assets. Although fertility may have declined, it remains a fundamentally important Chinese institution. Fertility is concentrated among women in the 20s, with urban fertility more compressed into shorter age interval than is the case in rural areas. There were campaigns to encourage abortion, sterilization, and IUD insertion in late 1982 and early 1983. The number of sterilizations/year increased from 5.1 million in 1982 to 20.8 million in 1983. As of 1983, the mix of contraceptive methods ranged as follows: 50% sterilization, 41% IUD, and 9% others. From 1984-85, the proportion of 1st births declined from 56% to 50%, with 2nd births absorbing the increase. In 1986-88, following a period of relative leniency, family planning goal became somewhat more stringent, and to responsibility systems, such as goal management in which couples together with multiple administrative levels must guarantee compliance with program objectives, are being emphasized. At the same time, several pilot programs allowing a 2nd child after substantial delay are being tested.

Spotlight on the media

CERN Multimedia

2007-01-01

Do you want to know more about how the media works, how to deal with journalists? How to maximise opportunity and minimise threat? Then please join us on 22 November. This session will cover how to work effectively with the media, including print, radio and TV. You’ll get an insight into how journalists and news rooms operate. You’ll learn to recognise both soft balls and traps - and develop the techniques for dealing with them. The challenges of explaining CERN to any media outlet will be dealt with too. This interactive presentation, given by Jessica Pryce-Jones, Managing Director of the consultancy firm iOpener Ltd, and Nisha Pillai, news anchor for BBC World, will be illustrated with various case studies. How to deal with the media: maximising opportunity and minimising threat Thursday 22 November, from 4.30 pm, Main Auditorium, Bldg. 500 Coffee break before the event at 4.00 pm

Molecules in the Spotlight

Energy Technology Data Exchange (ETDEWEB)

Cryan, James

2010-01-26

SLAC has just unveiled the world's first X-ray laser, the LCLS. This machine produces pulses of X-rays that are ten billion times brighter than those from conventional sources. One of the goals of this machine is to make movies of chemical reactions, including reactions necessary for life and reactions that might power new energy technologies. This public lecture will show the first results from the LCLS. As a first target, we have chosen nitrogen gas, the main component of the air we breathe. Using the unprecedented power of the LCLS X-rays as a blasting torch, we have created new forms of this molecule and with unique electronic arrangements. Please share with us the first insights from this new technology.

Spotlight on NHS labs

International Nuclear Information System (INIS)

Glover, Bryn

1988-01-01

A brief article examines a small group of national health service workers who may encounter the AIDS virus, reviews the changes they have devised to minimize the risks to themselves and considers the obstacles that remain to prevent the full implementation of these changes. The article also discusses the importance of reducing the radiation dose limits for workers. Ways of reducing occupational exposure of personnel involved in radiology, nuclear medicine and radiotherapy are described. It is argued that cash limits should never compromise worker safety. (U.K.)

Power spectral density of a single Brownian trajectory: what one can and cannot learn from it

Science.gov (United States)

Krapf, Diego; Marinari, Enzo; Metzler, Ralf; Oshanin, Gleb; Xu, Xinran; Squarcini, Alessio

2018-02-01

The power spectral density (PSD) of any time-dependent stochastic process X t is a meaningful feature of its spectral content. In its text-book definition, the PSD is the Fourier transform of the covariance function of X t over an infinitely large observation time T, that is, it is defined as an ensemble-averaged property taken in the limit T\\to ∞ . A legitimate question is what information on the PSD can be reliably obtained from single-trajectory experiments, if one goes beyond the standard definition and analyzes the PSD of a single trajectory recorded for a finite observation time T. In quest for this answer, for a d-dimensional Brownian motion (BM) we calculate the probability density function of a single-trajectory PSD for arbitrary frequency f, finite observation time T and arbitrary number k of projections of the trajectory on different axes. We show analytically that the scaling exponent for the frequency-dependence of the PSD specific to an ensemble of BM trajectories can be already obtained from a single trajectory, while the numerical amplitude in the relation between the ensemble-averaged and single-trajectory PSDs is a fluctuating property which varies from realization to realization. The distribution of this amplitude is calculated exactly and is discussed in detail. Our results are confirmed by numerical simulations and single-particle tracking experiments, with remarkably good agreement. In addition we consider a truncated Wiener representation of BM, and the case of a discrete-time lattice random walk. We highlight some differences in the behavior of a single-trajectory PSD for BM and for the two latter situations. The framework developed herein will allow for meaningful physical analysis of experimental stochastic trajectories.

THE LONGEST TIMESCALE X-RAY VARIABILITY REVEALS EVIDENCE FOR ACTIVE GALACTIC NUCLEI IN THE HIGH ACCRETION STATE

International Nuclear Information System (INIS)

Zhang Youhong

2011-01-01

The All Sky Monitor (ASM) on board the Rossi X-ray Timing Explorer has continuously monitored a number of active galactic nuclei (AGNs) with similar sampling rates for 14 years, from 1996 January to 2009 December. Utilizing the archival ASM data of 27 AGNs, we calculate the normalized excess variances of the 300-day binned X-ray light curves on the longest timescale (between 300 days and 14 years) explored so far. The observed variance appears to be independent of AGN black-hole mass and bolometric luminosity. According to the scaling relation of black-hole mass (and bolometric luminosity) from galactic black hole X-ray binaries (GBHs) to AGNs, the break timescales that correspond to the break frequencies detected in the power spectral density (PSD) of our AGNs are larger than the binsize (300 days) of the ASM light curves. As a result, the singly broken power-law (soft-state) PSD predicts the variance to be independent of mass and luminosity. Nevertheless, the doubly broken power-law (hard-state) PSD predicts, with the widely accepted ratio of the two break frequencies, that the variance increases with increasing mass and decreases with increasing luminosity. Therefore, the independence of the observed variance on mass and luminosity suggests that AGNs should have soft-state PSDs. Taking into account the scaling of the break timescale with mass and luminosity synchronously, the observed variances are also more consistent with the soft-state than the hard-state PSD predictions. With the averaged variance of AGNs and the soft-state PSD assumption, we obtain a universal PSD amplitude of 0.030 ± 0.022. By analogy with the GBH PSDs in the high/soft state, the longest timescale variability supports the standpoint that AGNs are scaled-up GBHs in the high accretion state, as already implied by the direct PSD analysis.

Data Series Subtraction with Unknown and Unmodeled Background Noise

Science.gov (United States)

Vitale, Stefano; Congedo, Giuseppe; Dolesi, Rita; Ferroni, Valerio; Hueller, Mauro; Vetrugno, Daniele; Weber, William Joseph; Audley, Heather; Danzmann, Karsten; Diepholz, Ingo;

Quantification of pore size distribution in reservoir rocks using MRI logging: A case study of South Pars Gas Field.

Science.gov (United States)

Ghojogh, Jalal Neshat; Esmaili, Mohammad; Noruzi-Masir, Behrooz; Bakhshi, Puyan

2017-12-01

Pore size distribution (PSD) is an important factor for controlling fluid transport through porous media. The study of PSD can be applicable in areas such as hydrocarbon storage, contaminant transport, prediction of multiphase flow, and analysis of the formation damage by mud infiltration. Nitrogen adsorption, centrifugation method, mercury injection, and X-ray computed tomography are commonly used to measure the distribution of pores. A core sample is occasionally not available because of the unconsolidated nature of reservoirs, high cost of coring operation, and program limitations. Magnetic resonance imaging logging (MRIL) is a proper logging technique that allows the direct measurement of the relaxation time of protons in pore fluids and correlating T 2 distribution to PSD using proper mathematical equations. It is nondestructive and fast and does not require core samples. In this paper, 8 core samples collected from the Dalan reservoir in South Pars Gas Field were studied by processing MRIL data and comparing them by PSD determined in the laboratory. By using the MRIL method, variation in PSD corresponding to the depth for the entire logged interval was determined. Moreover, a detailed mineralogical composition of the reservoir samples related to T 2 distribution was obtained. A good correlation between MRIL and mercury injection data was observed. High degree of similarity was also observed between T 2 distribution and PSD (R 2 = 0.85 to 0.91). Based on the findings from the MRIL method, the obtained values for clay bond water varied between 1E-6 and 1E-3µm, a range that is comprehended from an extra peak on the PSD curve. The frequent pore radius was determined to be 1µm. Copyright © 2017 Elsevier Ltd. All rights reserved.

Relationship of O2 Photodesorption in Photooxidation of Acetone on TiO2

International Nuclear Information System (INIS)

Henderson, Michael A.

2008-01-01

Organic photooxidation on TiO2 invariably involves the coexistence of organic species with oxygen on the surface at the same time. In the case of acetone and oxygen, both species exhibit their own interesting photochemistry on TiO2, but interdependences between the two are not understood. In this study, a rutile TiO2(110) surface possessing 7% surface oxygen vacancy sites is used as a model surface to probe the relationship between O2 photodesorption and acetone photodecomposition. Temperature programmed desorption (TPD) and photon stimulated desorption (PSD) measurements indicate that coadsorbed oxygen is essential to acetone photodecomposition on this surface, however the form of oxygen (molecular and dissociative) is not known. The first steps in acetone photodecomposition on TiO2(110) involve thermal activation with oxygen to form an acetone diolate ((CH3)2COO) species followed by photochemical decomposition to adsorbed acetate (CH3COO) and an ejected CH3 radical that is detected in PSD. Depending on the surface conditions, O2 PSD is also observed during the latter process. However, the time scales for the two PSD events (CH3 and O2) are quite different, with the former occurring at ∼10 times faster than the latter. By varying the preheating conditions or performing pre-irradiation on an O2 exposed surface, it becomes clear that the two PSD events are uncorrelated. That is, the O2 species responsible for O2 PSD is not a significant participant in the photochemistry of acetone on TiO2(110) and likely originates from a minority form of O2 on the surface. The CH3 and O2 PSD events do not appear to be in competition with each other suggesting either that ample charge carriers exist under the experimental conditions employed or that different charge carriers or excitation mechanisms are involved

UV photon and low-energy (5--150 eV) electron-stimulated processes at environmental interfaces

International Nuclear Information System (INIS)

Orlando, T.M.

1997-01-01

Irradiation of surfaces and interfaces with low-energy (5--150 eV) electrons and ultraviolet photons occurs during the storage of ''mixed'' (chemical/radioactive) waste forms and during processing steps which involve the use of low temperature plasmas. It is well known that electron- and photon-stimulated desorption (ESD and PSD) from wide band-gap materials and interfaces can be initiated by Auger decay of deep valence and shallow core holes. This process consists of hole production, Auger decay, reversal of the Madelung potential, and ion expulsion due to the Coulomb repulsion. ESD and PSD of neutrals also occurs and involves production of electron-hole pairs and excitons. Generally, neutral yields dominate ESD and PSD cross sections, which typically vary between ∼10 -16 and 10 -22 cm 2 . The authors present results on the ESD and PSD of environmentally relevant substrates such as ZrO 2 (100), soda-glass, and NaNO 3 . The major cation thresholds and yields indicate that ESD and PSD from these complex materials involves Auger stimulated events. In particular, desorption thresholds correlate with ionization of the O(2s), Zr(4p), Si(2p) and Na(2s) levels. The near band-gap threshold energy (∼5--7 eV) for the desorption of neutrals (i.e., atomic oxygen, NO, etc) demonstrate the overall importance of self-trapped and localized excitons in both ESD and PSD of typical ceramics and oxides

UniProt search blastx result: AK318565 [KOME

Lifescience Database Archive (English)

Full Text Available AK318565 J075199H10 B0TZM7|PSD_FRAP2 Phosphatidylserine decarboxylase proenzyme OS=Francisella philo...miragia subsp. philomiragia (strain ATCC 25017) GN=psd PE=3 SV=1 5.00E-22 ...

Time recording unit for a neutron time of flight spectrometer

International Nuclear Information System (INIS)

Puranik, Praful; Ajit Kiran, S.; Chandak, R.M.; Poudel, S.K.; Mukhopadhyay, R.

2011-01-01

Here the architecture and design of Time Recording Unit for a Neutron Time of Flight Spectrometer have been described. The Spectrometer would have an array of 50 Nos. of one meter long linear Position Sensitive Detector (PSD) placed vertically around the sample at a distance of 2000 mm. The sample receives periodic pulsed neutron beam coming through a Fermi chopper. The time and zone of detection of a scattered neutron in a PSD gives information of its flight time and path length, which will be used to calculate its energy. A neutron event zone (position) and time detection module for each PSD provides a 2 bit position/zone code and an event timing pulse. The path length assigned to a neutron detected in a zone (Z1, Z2 etc) in the PSD is the mean path length seen by the neutrons detected in that zone of the PSD. A Time recording unit described here receives event zone code and timing pulse for all the 50 detectors, tags a proper time window code to it, before streaming it to computer for calculation of the energy distribution of neutrons scattered from the sample

Power spectral density of velocity fluctuations estimated from phase Doppler data

Science.gov (United States)

Jedelsky, Jan; Lizal, Frantisek; Jicha, Miroslav

2012-04-01

Laser Doppler Anemometry (LDA) and its modifications such as PhaseDoppler Particle Anemometry (P/DPA) is point-wise method for optical nonintrusive measurement of particle velocity with high data rate. Conversion of the LDA velocity data from temporal to frequency domain - calculation of power spectral density (PSD) of velocity fluctuations, is a non trivial task due to nonequidistant data sampling in time. We briefly discuss possibilities for the PSD estimation and specify limitations caused by seeding density and other factors of the flow and LDA setup. Arbitrary results of LDA measurements are compared with corresponding Hot Wire Anemometry (HWA) data in the frequency domain. Slot correlation (SC) method implemented in software program Kern by Nobach (2006) is used for the PSD estimation. Influence of several input parameters on resulting PSDs is described. Optimum setup of the software for our data of particle-laden air flow in realistic human airway model is documented. Typical character of the flow is described using PSD plots of velocity fluctuations with comments on specific properties of the flow. Some recommendations for improvements of future experiments to acquire better PSD results are given.

Power spectral density of velocity fluctuations estimated from phase Doppler data

Directory of Open Access Journals (Sweden)

Jicha Miroslav

2012-04-01

Full Text Available Laser Doppler Anemometry (LDA and its modifications such as PhaseDoppler Particle Anemometry (P/DPA is point-wise method for optical nonintrusive measurement of particle velocity with high data rate. Conversion of the LDA velocity data from temporal to frequency domain – calculation of power spectral density (PSD of velocity fluctuations, is a non trivial task due to nonequidistant data sampling in time. We briefly discuss possibilities for the PSD estimation and specify limitations caused by seeding density and other factors of the flow and LDA setup. Arbitrary results of LDA measurements are compared with corresponding Hot Wire Anemometry (HWA data in the frequency domain. Slot correlation (SC method implemented in software program Kern by Nobach (2006 is used for the PSD estimation. Influence of several input parameters on resulting PSDs is described. Optimum setup of the software for our data of particle-laden air flow in realistic human airway model is documented. Typical character of the flow is described using PSD plots of velocity fluctuations with comments on specific properties of the flow. Some recommendations for improvements of future experiments to acquire better PSD results are given.

Age-Associated Changes in the Spectral and Statistical Parameters of Surface Electromyogram of Tibialis Anterior

Directory of Open Access Journals (Sweden)

Ariba Siddiqi

2016-01-01

Full Text Available Age-related neuromuscular change of Tibialis Anterior (TA is a leading cause of muscle strength decline among the elderly. This study has established the baseline for age-associated changes in sEMG of TA at different levels of voluntary contraction. We have investigated the use of Gaussianity and maximal power of the power spectral density (PSD as suitable features to identify age-associated changes in the surface electromyogram (sEMG. Eighteen younger (20–30 years and 18 older (60–85 years cohorts completed two trials of isometric dorsiflexion at four different force levels between 10% and 50% of the maximal voluntary contraction. Gaussianity and maximal power of the PSD of sEMG were determined. Results show a significant increase in sEMG’s maximal power of the PSD and Gaussianity with increase in force for both cohorts. It was also observed that older cohorts had higher maximal power of the PSD and lower Gaussianity. These age-related differences observed in the PSD and Gaussianity could be due to motor unit remodelling. This can be useful for noninvasive tracking of age-associated neuromuscular changes.

PACHE Trainee Spotlight: Roslyn Curry Featured on Thesis Thursday Radio Show

Science.gov (United States)

Roslyn Curry, a student at the University of Arizona (UA), was featured on a local radio program, Thesis Thursday, where she discussed her participation in the U54 PACHE Partnership for Native American Cancer Prevention (NACP) as a research trainee in Dr. William Montfort’s Lab at the University of Arizona Cancer Cente

Assessing support packs from an occupational hygiene perspective

CSIR Research Space (South Africa)

Pretorius, Cecilia J

2017-07-01

Full Text Available or the PSD. Particle Size Analysis (PSA) using laser light scattering was carried out on the bulk and the fine fraction samples to determine the PSD. The SWeRF method developed by IMA-EU (Pensis et al. 2013) contains the details of the meth- od... and only a brief summary is provided for the benefit of the reader. There are two approaches in SWeRF:  Calculation of the fine fraction from the PSA (i.e. SWeRFcalc): the PSD from the laser light scattering method is used in the formula provided...

Identification of proteins in the postsynaptic density fraction by mass spectrometry

DEFF Research Database (Denmark)

Walikonis, R S; Jensen, Ole Nørregaard; Mann, M

2000-01-01

Our understanding of the organization of postsynaptic signaling systems at excitatory synapses has been aided by the identification of proteins in the postsynaptic density (PSD) fraction, a subcellular fraction enriched in structures with the morphology of PSDs. In this study, we have completed...... not previously known to be constituents of the PSD fraction and 24 that had previously been associated with the PSD by other methods. The newly identified proteins include the heavy chain of myosin-Va (dilute myosin), a motor protein thought to be involved in vesicle trafficking, and the mammalian homolog...

Planetary Science Technology Infusion Study: Findings and Recommendations Status

Science.gov (United States)

Anderson, David J.; Sandifer, Carl E., II; Sarver-Verhey, Timothy R.; Vento, Daniel M.; Zakrajsek, June F.

2014-01-01

The Planetary Science Division (PSD) within the National Aeronautics and Space Administrations (NASA) Science Mission Directorate (SMD) at NASA Headquarters sought to understand how to better realize a scientific return on spacecraft system technology investments currently being funded. In order to achieve this objective, a team at NASA Glenn Research Center was tasked with surveying the science and mission communities to collect their insight on technology infusion and additionally sought inputs from industry, universities, and other organizations involved with proposing for future PSD missions. This survey was undertaken by issuing a Request for Information (RFI) activity that requested input from the proposing community on present technology infusion efforts. The Technology Infusion Study was initiated in March 2013 with the release of the RFI request. The evaluation team compiled and assessed this input in order to provide PSD with recommendations on how to effectively infuse new spacecraft systems technologies that it develops into future competed missions enabling increased scientific discoveries, lower mission cost, or both. This team is comprised of personnel from the Radioisotope Power Systems (RPS) Program and the In-Space Propulsion Technology (ISPT) Program staff.The RFI survey covered two aspects of technology infusion: 1) General Insight, including: their assessment of barriers to technology infusion as related to infusion approach; technology readiness; information and documentation products; communication; integration considerations; interaction with technology development areas; cost-capped mission areas; risk considerations; system level impacts and implementation; and mission pull. 2) Specific technologies from the most recent PSD Announcements of Opportunities (AOs): The Advanced Stirling Radioisotope Generator (ASRG), aerocapture and aeroshell hardware technologies, the NASA Evolutionary Xenon Thruster (NEXT) ion propulsion system, and the

Influence of wind turbines on seismic stations in the upper rhine graben, SW Germany

Science.gov (United States)

Zieger, Toni; Ritter, Joachim R. R.

2018-01-01

By analysing long- and short-term seismological measurements at wind farms close to the town of Landau, SW Germany, we present new insights into ground motion signals from wind turbines (WTs) at local seismic stations. Because of their need to be located in similar regions with sparsely anthropogenic activities, wind turbines impact seismic stations and their recordings in a way that is not yet fully understood by researchers. To ensure the undisturbed recording tasks of a regional seismic array or a single station by a protected area around those endangered stations, it is very important to investigate the behavior of WTs as a seismic source. For that reason, we calculate averaged one-hour long spectra of the power spectral density (PSD) before and after the installation of a new wind farm within the investigated area. These PSD are ordered according to the rotation speed. We observe a clear increase of the PSD level after the WT installation in a frequency range of 0.5 to 10 Hz up to a distance of 5.5 km away from the WT. By analysing seismic borehole data, we also observe a decrease of the PSD of wind dependent signals with depth. The impact of wind-dependent signals is found to be much more pronounced for the shallower station (150 m depth) than for the deeper one (305 m depth). Using short-term profile measurements, we fit a power-law decay proportional to 1/ r b to the main WT-induced PSD peaks and differentiate between near-field and far-field effects of ground motions. For low frequencies in the range from 1 to 4 Hz, we determine a b value of 0.78 to 0.85 for the far field, which is consistent with surface waves. The b value increases (up to 1.59) with increasing frequencies (up to 5.5 Hz), which is obviously due to attenuating effects like scattering or anelasticity. These results give a better understanding of the seismic wavefield interactions between wind turbines (or wind farms) with nearby seismic stations, including borehole installations, in a

76 FR 26933 - Approval and Promulgation of Implementation Plans; Connecticut: Prevention of Significant...

Science.gov (United States)

2011-05-10

... Promulgation of Implementation Plans; Connecticut: Prevention of Significant Deterioration; Greenhouse Gas... Significant Deterioration (PSD) program. First, the revision provides Connecticut with authority to issue PSD... Regional Office, Office of Ecosystem Protection, Air Permits, Toxics, and Indoor Air Programs Unit, 5 Post...

Position sensitive detector used to detect beam profile

International Nuclear Information System (INIS)

Zhao Xiaoyan; Zhao Zhizheng; Zu Kailing; Zheng Jianhua; Wang Yifang

2003-01-01

In order to study the detecting system of the residual-gas beam profile, we introduce the principle and construction of the Position Sensitive Detector (PSD). The performance of PSD is tested. Position resolution, position linearity, detection efficiency and background are obtained

English L2 reading getting to the bottom

CERN Document Server

Birch, Barbara M

2014-01-01

English L2 Reading, Third Edition offers teachers research-based insights into bottom-up skills in reading English as a second language and a solid foundation on which to build reading instruction. Core linguistic and psycholinguistic concepts are presented within the context of their application to teaching. The goal is to balance or supplement (not replace) top-down approaches and methodologies with effective low-level options for teaching English reading. The text's pedagogical features- Questions, Study Guide Questions. Discussion Questions, Spotlight on Teaching sections- engage readers o

Understanding the Design and Performance of Emissions Trading Systems for Greenhouse Gas Emissions

Energy Technology Data Exchange (ETDEWEB)

Toman, M.

1999-01-31

Research Spotlight presents new research findings and projects underway at Resources for the Future that are relevant to the analysis of climate change policy. As interest in greenhouse gas trading policies grows in the United States and other Annex I countries, so does the need for stronger analytical tools. The paper by Tietenberg in this collection lays out some of the principal conceptual issues that analysts face in providing more accurate and relevant tools and results for decisionmakers. In this paper we build on Tietenberg's analysis to consider some of the key modeling challenges that analysts face in developing an improved capacity for quantitatively assessing real-world policies.

Method development and validation for measuring the particle size distribution of pentaerythritol tetranitrate (PETN) powders.

Energy Technology Data Exchange (ETDEWEB)

Young, Sharissa Gay

2005-09-01

Currently, the critical particle properties of pentaerythritol tetranitrate (PETN) that influence deflagration-to-detonation time in exploding bridge wire detonators (EBW) are not known in sufficient detail to allow development of a predictive failure model. The specific surface area (SSA) of many PETN powders has been measured using both permeametry and gas absorption methods and has been found to have a critical effect on EBW detonator performance. The permeametry measure of SSA is a function of particle shape, packed bed pore geometry, and particle size distribution (PSD). Yet there is a general lack of agreement in PSD measurements between laboratories, raising concerns regarding collaboration and complicating efforts to understand changes in EBW performance related to powder properties. Benchmarking of data between laboratories that routinely perform detailed PSD characterization of powder samples and the determination of the most appropriate method to measure each PETN powder are necessary to discern correlations between performance and powder properties and to collaborate with partnering laboratories. To this end, a comparison was made of the PSD measured by three laboratories using their own standard procedures for light scattering instruments. Three PETN powder samples with different surface areas and particle morphologies were characterized. Differences in bulk PSD data generated by each laboratory were found to result from variations in sonication of the samples during preparation. The effect of this sonication was found to depend on particle morphology of the PETN samples, being deleterious to some PETN samples and advantageous for others in moderation. Discrepancies in the submicron-sized particle characterization data were related to an instrument-specific artifact particular to one laboratory. The type of carrier fluid used by each laboratory to suspend the PETN particles for the light scattering measurement had no consistent effect on the resulting

Comparisons of Particulate Size Distributions from Multiple Combustion Strategies

Science.gov (United States)

Zhang, Yizhou

In this study, a comparison of particle size distribution (PSD) measurements from eight different combustion strategies was conducted at four different load-speed points. The PSDs were measured using a scanning mobility particle sizer (SMPS) together with a condensation particle counter (CPC). To study the influence of volatile particles, PSD measurements were performed with and without a volatile particle remover (thermodenuder, TD) at both low and high dilution ratios. The common engine platform utilized in the experiment helps to eliminate the influence of background particulate and ensures similarity in dilution conditions. The results show a large number of volatile particles were present under LDR sample conditions for most of the operating conditions. The use of a TD, especially when coupled with HDR, was demonstrated to be effective at removing volatile particles and provided consistent measurements across all combustion strategies. The PSD comparison showed that gasoline premixed combustion strategies such as HCCI and GCI generally have low PSD magnitudes for particle sizes greater than the Particle Measurement Programme (PMP) cutoff diameter (23 nm), and the PSDs were highly nuclei-mode particle dominated. The strategies using diesel as the only fuel (DLTC and CDC) generally showed the highest particle number emissions for particles larger than 23 nm and had accumulation-mode particle dominated PSDs. A consistent correlation between the increase of the direct-injection of diesel fuel and a higher fraction of accumulation-mode particles was observed over all combustion strategies. A DI fuel substitution study and injector nozzle geometry study were conducted to better understand the correlation between PSD shape and DI fueling. It was found that DI fuel properties has a clear impact on PSD behavior for CDC and NG DPI. Fuel with lower density and lower sooting tendency led to a nuclei-mode particle dominated PSD shape. For NG RCCI, accumulation

Puffy Skin Disease Is an Emerging Transmissible Condition in Rainbow Trout Oncorhynchus mykiss Walbaum.

Science.gov (United States)

Cano, Irene; Verner-Jeffreys, David W; van Aerle, Ronny; Paley, Richard K; Peeler, Edmund J; Green, Matthew; Rimmer, Georgina S E; Savage, Jacqueline; Joiner, Claire L; Bayley, Amanda E; Mewett, Jason; Hulland, Jonathan; Feist, Stephen W

2016-01-01

The transmission of puffy skin disease (PSD) to rainbow trout Oncorhynchus mykiss Walbaum was tested in the laboratory by conducting co-habitation challenges with puffy skin (PS)-affected fish (Trojans) collected from the field. Two separate challenges were conducted using Trojans sourced from two different sites and diploid (first trial) or triploid (second trial) naïve fish. PSD-specific clinical signs were observed in both groups of naïve fish, with 66% of the fish sampled during the challenges showing signs of varying severity. The first clinical features of PSD were presented as white oval skin patches on one or both flanks 15-21 days post-challenge (dpc). The extent of the lesions ranged from 10 to 90% of the body surface, depending on the severity of the lesion. Both the severity and number of affected fish increased during the challenge. Macroscopically, oedema of the skin and multifocal petechial haemorrhaging were observed towards the end of the trials. Abnormal fish behaviour consisting of "flashing" and excessive mucous production was noted from 15 dpc onwards. Fish with severe PSD lesions also displayed inappetence and associated emaciation. Rodlet cells were observed in 41% of the fresh skin scrapes analysed from the second trial. Histologically epidermal oedema was observed in 31% of the naive fish showing gross pathology, with additional 12% displaying epidermal hyperplasia, mostly observed at the end of the challenge. Other concomitant features of the PSD lesions in challenged fish were epithelial erosion and sloughing, and occasionally mild or focal inflammation. No consistent pathology of internal organs was observed. The parasites Ichthyophthirius multifiliis and Ichthyobodo necator were observed in skin samples of a proportion of naïve challenged fish and in Trojans but not in control fish. The presence of these and other known fish pathogens in the skin of PSD-fish was confirmed by high-throughput sequencing analysis. In summary, we have

Pulse-shape discrimination in IAEA tritium proportional counters

International Nuclear Information System (INIS)

Florkowski, T.

1981-01-01

Two systems of pulse-shape discrimination (PSD) for the reduction of background in low-level proportional counters were tested. A tentative conclusion is drawn that both PSD systems, although they decrease slightly the meson background, do not bring improvement in the analytical accuracy

Historical overview of development policies and institutions in the Netherlands, in the context of private sector development and (productive) employment creation

NARCIS (Netherlands)

Kazimierczuk, A.H.

2015-01-01

This paper reviews the Dutch development cooperation policies for the years 1949-2015 with particular attention for private sector development (PSD). Over the years, poverty alleviation, private sector development and security have been dominant focus areas of Dutch development cooperation, with PSD

An Efficient Digital Pulse Shape Discrimination Technique for Scintillation Detectors Based on FPGA

International Nuclear Information System (INIS)

Kamel, M.S.

2014-01-01

Different techniques for pulse discrimination (PSD) of the scintillation pulses have been developed. The PSD of scintillation pulese can been used in several applications as Positron Emission Topography (PET) system. Each technique analyzes the resulting pulses from the absorption of radiation in the scintillation pulses were filtered and digitized then it is captured using DAQ, and it sent to the host computer for processing. The spatial resolution of images that generated in PET system can be improved by applying the proposed PSD. In this thesis various digital PSD techniques are proposed to discriminate the scintillation pulses. These techniques are based on discrete sine transform (DST). discrete cosine transform (DCT). Discrete hartley transform (DHT), Discrete Goertzel transform (DGT),and principal component analysis (PCA). Then the output coefficients of the discrete transforms are classified using one of the following classifiers T-test,tuned, or support vector machine (SVM).

Laser tests of silicon detectors

Czech Academy of Sciences Publication Activity Database

Doležal, Z.; Escobar, C.; Gadomski, S.; Garcia, C.; Gonzales, S.; Kodyš, Peter; Kubík, P.; Lacasta, C.; Marti, S.; Mitsou, V. A.; Moorhead, G. F.; Phillips, P. W.; Řezníček, P.; Slavík, Radan

2007-01-01

Roč. 573, 1/2 (2007), s. 12-15 ISSN 0168-9002. [International Conference on Position-Sensitive Detectors - PSD /7./. Liverpool, 12.09.2005-16.09.2005] R&D Projects: GA AV ČR(CZ) KJB200670601 Institutional research plan: CEZ:AV0Z20670512 Keywords : semiconductor devices Subject RIV: BH - Optics, Masers, Lasers Impact factor: 1.114, year: 2007

Effects of cocaine, methamphetamine and modafinil challenge on sleep rebound after paradoxical sleep deprivation in rats

Directory of Open Access Journals (Sweden)

R.C.S Martins

2008-01-01

Full Text Available Sleep loss is both common and critically relevant to our society and might lead to the abuse of psychostimulants such as amphetamines, cocaine and modafinil. Since psychoactive substance abuse often occurs within a scenario of sleep deficit, the purpose of this investigation was to compare the sleep patterns of rats challenged with cocaine (7 mg/kg, ip, methamphetamine (7 mg/kg, ip, or modafinil (100 mg/kg, ip subsequent to paradoxical sleep deprivation (PSD for 96 h. Our results show that, immediately after 96 h of PSD, rats (10 per group that were injected with a psychostimulant presented lower percentages of paradoxical sleep compared to those injected with saline (P < 0.01. Regarding slow wave sleep (SWS, rats injected with psychostimulants after PSD presented a late rebound (on the second night subsequent to the injection in the percentage of this phase of sleep when compared to PSD rats injected with saline (P < 0.05. In addition, the current study has produced evidence of the characteristic effect of each drug on sleep architecture. Home cage control rats injected with modafinil and methamphetamine showed a reduction in SWS compared with the saline group. Methamphetamine affected sleep patterns most, since it significantly reduced paradoxical sleep, SWS and sleep efficiency before and after PSD compared to control (P < 0.05. Cocaine was the psychostimulant causing the least changes in sleep pattern in relation to those observed after saline injection. Therefore, our results suggest that abuse of these psychostimulants in a PSD paradigm aggravates their impact on sleep patterns.