WorldWideScience

Sample records for pscbox model developed

  1. Strategic Leadership Development Model

    Science.gov (United States)

    2012-03-19

    Strategic Leadership Development Model by Brigadier Farhat Abbas Sani Pakistan Army United States Army War College...Strategic Leadership Development Model 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Brigadier...Stephen J Gerras AND ADDRESS(ES) 8. PERFORMING ORGANIZATION REPORT NUMBER Department of Command Leadership and Management

  2. Developing mathematical modelling competence

    DEFF Research Database (Denmark)

    Blomhøj, Morten; Jensen, Tomas Højgaard

    2003-01-01

    In this paper we introduce the concept of mathematical modelling competence, by which we mean being able to carry through a whole mathematical modelling process in a certain context. Analysing the structure of this process, six sub-competences are identified. Mathematical modelling competence...... cannot be reduced to these six sub-competences, but they are necessary elements in the development of mathematical modelling competence. Experience from the development of a modelling course is used to illustrate how the different nature of the sub-competences can be used as a tool for finding...... the balance between different kinds of activities in a particular educational setting. Obstacles of social, cognitive and affective nature for the students' development of mathematical modelling competence are reported and discussed in relation to the sub-competences....

  3. Modelling river dune development

    NARCIS (Netherlands)

    Paarlberg, Andries; Weerts, H.J.T.; Dohmen-Janssen, Catarine M.; Ritsema, I.L; Hulscher, Suzanne J.M.H.; van Os, A.G.; Termes, A.P.P.

    2005-01-01

    Since river dunes influence flow resistance, predictions of dune dimensions are required to make accurate water level predictions. A model approach to simulate developing river dunes is presented. The model is set-up to be appropriate, i.e. as simple as possible, but with sufficient accuracy for

  4. Rectenna thermal model development

    Science.gov (United States)

    Kadiramangalam, Murall; Alden, Adrian; Speyer, Daniel

    1992-01-01

    Deploying rectennas in space requires adapting existing designs developed for terrestrial applications to the space environment. One of the major issues in doing so is to understand the thermal performance of existing designs in the space environment. Toward that end, a 3D rectenna thermal model has been developed, which involves analyzing shorted rectenna elements and finite size rectenna element arrays. A shorted rectenna element is a single element whose ends are connected together by a material of negligible thermal resistance. A shorted element is a good approximation to a central element of a large array. This model has been applied to Brown's 2.45 GHz rectenna design. Results indicate that Brown's rectenna requires redesign or some means of enhancing the heat dissipation in order for the diode temperature to be maintained below 200 C above an output power density of 620 W/sq.m. The model developed in this paper is very general and can be used for the analysis and design of any type of rectenna design of any frequency.

  5. Selected sports talent development models

    Directory of Open Access Journals (Sweden)

    Michal Vičar

    2017-06-01

    Full Text Available Background: Sports talent in the Czech Republic is generally viewed as a static, stable phenomena. It stands in contrast with widespread praxis carried out in Anglo-Saxon countries that emphasise its fluctuant nature. This is reflected in the current models describing its development. Objectives: The aim is to introduce current models of talent development in sport. Methods: Comparison and analysing of the following models: Balyi - Long term athlete development model, Côté - Developmental model of sport participation, Csikszentmihalyi - The flow model of optimal expertise, Bailey and Morley - Model of talent development. Conclusion: Current models of sport talent development approach talent as dynamic phenomenon, varying in time. They are based in particular on the work of Simonton and his Emergenic and epigenic model and of Gagné and his Differentiated model of giftedness and talent. Balyi's model is characterised by its applicability and impications for practice. Côté's model highlights the role of family and deliberate play. Both models describe periodization of talent development. Csikszentmihalyi's flow model explains how the athlete acquires experience and develops during puberty based on the structure of attention and flow experience. Bailey and Morley's model accents the situational approach to talent and development of skills facilitating its growth.

  6. Developing New Models for Collection Development.

    Science.gov (United States)

    Stoffle, Carla J.; Fore, Janet; Allen, Barbara

    1999-01-01

    Discusses the need to develop new models for collection development in academic libraries, based on experiences at the University of Arizona. Highlights include changes in the organizational chart; focusing on users' information goals and needs; integrative services; shared resources; interlibrary loans; digital technology; and funding. (LRW)

  7. Econometric models for biohydrogen development.

    Science.gov (United States)

    Lee, Duu-Hwa; Lee, Duu-Jong; Veziroglu, Ayfer

    2011-09-01

    Biohydrogen is considered as an attractive clean energy source due to its high energy content and environmental-friendly conversion. Analyzing various economic scenarios can help decision makers to optimize development strategies for the biohydrogen sector. This study surveys econometric models of biohydrogen development, including input-out models, life-cycle assessment approach, computable general equilibrium models, linear programming models and impact pathway approach. Fundamentals of each model were briefly reviewed to highlight their advantages and disadvantages. The input-output model and the simplified economic input-output life-cycle assessment model proved most suitable for economic analysis of biohydrogen energy development. A sample analysis using input-output model for forecasting biohydrogen development in the United States is given. Copyright © 2011 Elsevier Ltd. All rights reserved.

  8. Models for Sustainable Regional Development

    DEFF Research Database (Denmark)

    Rasmussen, Lauge Baungaard

    2008-01-01

    The chapter presents a model for integrated cross-cultural knowledge building and entrepreneurship. In addtion, narrative and numeric simulations methods are suggested to promote a further development and implementation of the model in China.......The chapter presents a model for integrated cross-cultural knowledge building and entrepreneurship. In addtion, narrative and numeric simulations methods are suggested to promote a further development and implementation of the model in China....

  9. Advanced Mirror & Modelling Technology Development

    Science.gov (United States)

    Effinger, Michael; Stahl, H. Philip; Abplanalp, Laura; Maffett, Steven; Egerman, Robert; Eng, Ron; Arnold, William; Mosier, Gary; Blaurock, Carl

    2014-01-01

    The 2020 Decadal technology survey is starting in 2018. Technology on the shelf at that time will help guide selection to future low risk and low cost missions. The Advanced Mirror Technology Development (AMTD) team has identified development priorities based on science goals and engineering requirements for Ultraviolet Optical near-Infrared (UVOIR) missions in order to contribute to the selection process. One key development identified was lightweight mirror fabrication and testing. A monolithic, stacked, deep core mirror was fused and replicated twice to achieve the desired radius of curvature. It was subsequently successfully polished and tested. A recently awarded second phase to the AMTD project will develop larger mirrors to demonstrate the lateral scaling of the deep core mirror technology. Another key development was rapid modeling for the mirror. One model focused on generating optical and structural model results in minutes instead of months. Many variables could be accounted for regarding the core, face plate and back structure details. A portion of a spacecraft model was also developed. The spacecraft model incorporated direct integration to transform optical path difference to Point Spread Function (PSF) and between PSF to modulation transfer function. The second phase to the project will take the results of the rapid mirror modeler and integrate them into the rapid spacecraft modeler.

  10. Kantian Model of Moral Development.

    Science.gov (United States)

    Yun, Hyun Sub

    A Kantian model of moral development already tested on adolescents was further tested on normal and delinquent Korean adults. The model, based on the philosophy of Kant, starts its causality from the self, moves from the self to parental images, advances from parental images to duty and legality, and moves from duty and legality to a moral…

  11. Model Development for Graphene Spintronics

    Science.gov (United States)

    2015-09-21

    5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) University of Minnesota 200 Union...SUPPLEMENTARY NOTES 14. ABSTRACT The goal is to develop charge and spin carrier scattering models and device models, and to explore the physics...that enable and limit the operation of graphene spin valves. The models are based on the low energy linear dispersion relation of the graphene band

  12. Prognosis model for stand development

    Science.gov (United States)

    Albert R. Stage

    1973-01-01

    Describes a set of computer programs for developing prognoses of the development of existing stand under alternative regimes of management. Calibration techniques, modeling procedures, and a procedure for including stochastic variation are described. Implementation of the system for lodgepole pine, including assessment of losses attributed to an infestation of mountain...

  13. OSPREY Model Development Status Update

    Energy Technology Data Exchange (ETDEWEB)

    Veronica J Rutledge

    2014-04-01

    During the processing of used nuclear fuel, volatile radionuclides will be discharged to the atmosphere if no recovery processes are in place to limit their release. The volatile radionuclides of concern are 3H, 14C, 85Kr, and 129I. Methods are being developed, via adsorption and absorption unit operations, to capture these radionuclides. It is necessary to model these unit operations to aid in the evaluation of technologies and in the future development of an advanced used nuclear fuel processing plant. A collaboration between Fuel Cycle Research and Development Offgas Sigma Team member INL and a NEUP grant including ORNL, Syracuse University, and Georgia Institute of Technology has been formed to develop off gas models and support off gas research. Georgia Institute of Technology is developing fundamental level model to describe the equilibrium and kinetics of the adsorption process, which are to be integrated with OSPREY. This report discusses the progress made on expanding OSPREY to be multiple component and the integration of macroscale and microscale level models. Also included in this report is a brief OSPREY user guide.

  14. USEPA Resistance Management Model development

    Science.gov (United States)

    The US EPA requires registrants of plant incorporated protectant (PIP) crops to provide information relating to the time frame for pest resistance development related to the control traits of the crop. Simulation models are used to evaluate the future conditions for resistance de...

  15. Motorola Secure Software Development Model

    Directory of Open Access Journals (Sweden)

    Francis Mahendran

    2008-08-01

    Full Text Available In today's world, the key to meeting the demand for improved security is to implement repeatable processes that reliably deliver measurably improved security. While many organizations have announced efforts to institutionalize a secure software development process, there is little or no industry acceptance for a common process improvement framework for secure software development. Motorola has taken the initiative to develop such a framework, and plans to share this with the Software Engineering Institute for possible inclusion into its Capability Maturity Model Integration (CMMI®. This paper will go into the details of how Motorola is addressing this issue. The model that is being developed is designed as an extension of the existing CMMI structure. The assumption is that the audience will have a basic understanding of the SEI CMM® / CMMI® process framework. The paper will not describe implementation details of a security process model or improvement framework, but will address WHAT security practices are required for a company with many organizations operating at different maturity levels. It is left to the implementing organization to answer the HOW, WHEN, WHO and WHERE aspects. The paper will discuss how the model is being implemented in the Motorola Software Group.

  16. Deformable human body model development

    Energy Technology Data Exchange (ETDEWEB)

    Wray, W.O.; Aida, T.

    1998-11-01

    This is the final report of a three-year, Laboratory Directed Research and Development (LDRD) project at the Los Alamos National Laboratory (LANL). A Deformable Human Body Model (DHBM) capable of simulating a wide variety of deformation interactions between man and his environment has been developed. The model was intended to have applications in automobile safety analysis, soldier survivability studies and assistive technology development for the disabled. To date, we have demonstrated the utility of the DHBM in automobile safety analysis and are currently engaged in discussions with the U.S. military involving two additional applications. More specifically, the DHBM has been incorporated into a Virtual Safety Lab (VSL) for automobile design under contract to General Motors Corporation. Furthermore, we have won $1.8M in funding from the U.S. Army Medical Research and Material Command for development of a noninvasive intracranial pressure measurement system. The proposed research makes use of the detailed head model that is a component of the DHBM; the project duration is three years. In addition, we have been contacted by the Air Force Armstrong Aerospace Medical Research Laboratory concerning possible use of the DHBM in analyzing the loads and injury potential to pilots upon ejection from military aircraft. Current discussions with Armstrong involve possible LANL participation in a comparison between DHBM and the Air Force Articulated Total Body (ATB) model that is the current military standard.

  17. Developing + Using Models in Physics

    Science.gov (United States)

    Campbell, Todd; Neilson, Drew; Oh, Phil Seok

    2013-01-01

    Of the eight practices of science identified in "A Framework for K-12 Science Education" (NRC 2012), helping students develop and use models has been identified by many as an anchor (Schwarz and Passmore 2012; Windschitl 2012). In instruction, disciplinary core ideas, crosscutting concepts, and scientific practices can be meaningfully…

  18. Supo Thermal Model Development II

    Energy Technology Data Exchange (ETDEWEB)

    Wass, Alexander Joseph [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-07-14

    This report describes the continuation of the Computational Fluid Dynamics (CFD) model of the Supo cooling system described in the report, Supo Thermal Model Development1, by Cynthia Buechler. The goal for this report is to estimate the natural convection heat transfer coefficient (HTC) of the system using the CFD results and to compare those results to remaining past operational data. Also, the correlation for determining radiolytic gas bubble size is reevaluated using the larger simulation sample size. The background, solution vessel geometry, mesh, material properties, and boundary conditions are developed in the same manner as the previous report. Although, the material properties and boundary conditions are determined using the appropriate experiment results for each individual power level.

  19. Software Development Risk Management Model

    OpenAIRE

    Islam, Shareeful

    2011-01-01

    Risk management is an effective tool to control risks in software projects and increases the likelihood of project success. Risk management needs to be integrated as early as possible in the project. This dissertation proposes a Goal-driven Software Development Risk Management Model (GSRM) and explicitly integrates it into requirements engineering phase. This integration provides an early warning of potential problems so that both preventive and corrective actions can be undertaken to avoid t...

  20. Development Model for Research Infrastructures

    Science.gov (United States)

    Wächter, Joachim; Hammitzsch, Martin; Kerschke, Dorit; Lauterjung, Jörn

    2015-04-01

    . The maturity of individual scientific domains differs considerably. • Technologically and organisationally many different RI components have to be integrated. Individual systems are often complex and have a long-term history. Existing approaches are on different maturity levels, e.g. in relation to the standardisation of interfaces. • The concrete implementation process consists of independent and often parallel development activities. In many cases no detailed architectural blue-print for the envisioned system exists. • Most of the funding currently available for RI implementation is provided on a project basis. To increase the synergies in infrastructure development the authors propose a specific RI Maturity Model (RIMM) that is specifically qualified for open system-of-system environments. RIMM is based on the concepts of Capability Maturity Models for organisational development, concretely the Levels of Conceptual Interoperability Model (LCIM) specifying the technical, syntactical, semantic, pragmatic, dynamic, and conceptual layers of interoperation [1]. The model is complemented by the identification and integration of growth factors (according to the Nolan Stages Theory [2]). These factors include supply and demand factors. Supply factors comprise available resources, e.g., data, services and IT-management capabilities including organisations and IT-personal. Demand factors are the overall application portfolio for RIs but also the skills and requirements of scientists and communities using the infrastructure. RIMM thus enables a balanced development process of RI and RI components by evaluating the status of the supply and demand factors in relation to specific levels of interoperability. [1] Tolk, A., Diallo, A., Turnitsa, C. (2007): Applying the Levels of Conceptual Interoperability Model in Support of Integratability, Interoperability, and Composability for System-of-Systems Engineering. Systemics, Cybernetics and Informatics, Volume 5 - Number 5. [2

  1. Developing Personal Network Business Models

    DEFF Research Database (Denmark)

    Saugstrup, Dan; Henten, Anders

    2006-01-01

    on the 'state of the art' in the field of business modeling. Furthermore, the paper suggests three generic business models for PNs: a service oriented model, a self-organized model, and a combination model. Finally, examples of relevant services and applications in relation to three different cases......The aim of the paper is to examine the issue of business modeling in relation to personal networks, PNs. The paper builds on research performed on business models in the EU 1ST MAGNET1 project (My personal Adaptive Global NET). The paper presents the Personal Network concept and briefly reports...... are presented and analyzed in light of business modeling of PN....

  2. Developing the Business Modelling Method

    OpenAIRE

    Meertens, Lucas Onno; Iacob, Maria Eugenia; Nieuwenhuis, Lambertus Johannes Maria; Shishkov, B; Shishkov, Boris

    2011-01-01

    Currently, business modelling is an art, instead of a science, as no scientific method for business modelling exists. This, and the lack of using business models altogether, causes many projects to end after the pilot stage, unable to fulfil their apparent promise. We propose a structured method to create “as-is” business models in a repeatable manner. The method consists of the following steps: identify the involved roles, recognize relations among roles, specify the main activities, and qua...

  3. Developing the Business Modelling Method

    NARCIS (Netherlands)

    Meertens, Lucas Onno; Iacob, Maria Eugenia; Nieuwenhuis, Lambertus Johannes Maria; Shishkov, B; Shishkov, Boris

    2011-01-01

    Currently, business modelling is an art, instead of a science, as no scientific method for business modelling exists. This, and the lack of using business models altogether, causes many projects to end after the pilot stage, unable to fulfil their apparent promise. We propose a structured method to

  4. Curriculum Development: A Philosophical Model.

    Science.gov (United States)

    Bruening, William H.

    Presenting models based on the philosophies of Carl Rogers, John Dewey, Erich Fromm, and Jean-Paul Sartre, this paper proposes a philosophical approach to education and concludes with pragmatic suggestions concerning teaching based on a fully-functioning-person model. The fully-functioning person is characterized as being open to experience,…

  5. Coastal Surveillance Baseline Model Development

    Science.gov (United States)

    2015-02-27

    Definition of aircraft-object-level Constraints in the Basic Properties window (Figure 3-4) as a simplistic approach to modelling the radar sensor envelope ...STK (selected as WGS-84). STK is capable of calculating when sensors are able to see ( detect ) specified targets based on geometry, as well as sensor...option); System gain divided by system temperature; Polarization; Rain model (selectable); Demodulator type (selectable or user-defined); Filter

  6. Development of a technoeconomic model

    DEFF Research Database (Denmark)

    Adjin, Daniel Michael Okwabi; Tadayoni, Reza

    2011-01-01

    In this article, we discuss the key technical features to be considered for developing and deploying intelligent transportation systems (ITSs) in developing countries. The empirical data are taken from a detailed case study of ITS deployment in Ghana. The methodology used for data collection...... included interviews and surveys-face-to-face discussions and questionnaires. The results show that deployment of intelligent vehicle tracking technology (IVTT) will address the problems of inefficiencies experienced in the Ghanaian road transport haulage tracking industry. Research for ITS development...

  7. Maturity Models Development in IS Research

    DEFF Research Database (Denmark)

    Lasrado, Lester Allan; Vatrapu, Ravi; Andersen, Kim Normann

    2015-01-01

    Maturity Model (CMM). Only recently have there been some research efforts to standardize maturity model development. We also identify three dominant views of maturity models and provide guidelines for various approaches of constructing maturity models with a standard vocabulary. We finally propose using......Maturity models are widespread in IS research and in particular, IT practitioner communities. However, theoretically sound, methodologically rigorous and empirically validated maturity models are quite rare. This literature review paper focuses on the challenges faced during the development...... of maturity models. Specifically, it explores maturity models literature in IS and standard guidelines, if any to develop maturity models, challenges identified and solutions proposed. Our systematic literature review of IS publications revealed over hundred and fifty articles on maturity models. Extant...

  8. Macroeconomic model of national economy development

    Directory of Open Access Journals (Sweden)

    E. Naval

    1996-03-01

    Full Text Available Some approaches to modeling of national economy development are considered. Methods and models for determination of forecasting values of macroeconomic parameters are proposed at availability or absence of external financing.

  9. NC truck network model development research.

    Science.gov (United States)

    2008-09-01

    This research develops a validated prototype truck traffic network model for North Carolina. The model : includes all counties and metropolitan areas of North Carolina and major economic areas throughout the : U.S. Geographic boundaries, population a...

  10. Development of a generalized integral jet model

    DEFF Research Database (Denmark)

    Duijm, Nijs Jan; Kessler, A.; Markert, Frank

    2017-01-01

    Integral type models to describe stationary plumes and jets in cross-flows (wind) have been developed since about 1970. These models are widely used for risk analysis, to describe the consequences of many different scenarios. Alternatively, CFD codes are being applied, but computational...... model is needed to describe the rapid combustion of the flammable part of the plume (flash fire) and a third model has to be applied for the remaining jet fire. The objective of this paper is to describe the first steps of the development of an integral-type model describing the transient development...... and decay of a jet of flammable gas after a release from a pressure container. The intention is to transfer the stationary models to a fully transient model, capable to predict the maximum extension of short-duration, high pressure jets. The model development is supported by conducting a set of transient...

  11. Organization Development: Strategies and Models.

    Science.gov (United States)

    Beckhard, Richard

    This book, written for managers, specialists, and students of management, is based largely on the author's experience in helping organization leaders with planned-change efforts, and on related experience of colleagues in the field. Chapter 1 presents the background and causes for the increased concern with organization development and planned…

  12. Stated Preference Economic Development Model

    Science.gov (United States)

    2015-02-01

    economic development in your community and Afghanistan. Do you give your consent for me to proceed?” M-21. Informed Consent _____ ( tick ...dairy cows , and medicine for livestock. The villagers will form a council in order to estimate the costs and implementation of the project. The

  13. Yield model development project implementation plan

    Science.gov (United States)

    Ambroziak, R. A.

    1982-01-01

    Tasks remaining to be completed are summarized for the following major project elements: (1) evaluation of crop yield models; (2) crop yield model research and development; (3) data acquisition processing, and storage; (4) related yield research: defining spectral and/or remote sensing data requirements; developing input for driving and testing crop growth/yield models; real time testing of wheat plant process models) and (5) project management and support.

  14. Modeling energy and development: an evaluation of models and concepts

    NARCIS (Netherlands)

    van Ruijven, B.J.|info:eu-repo/dai/nl/304834521; Urban, F.; Benders, R.J.M.; Moll, H.C.; van der Sluijs, J.P.|info:eu-repo/dai/nl/073427489; de Vries, B.|info:eu-repo/dai/nl/068361599; van Vuuren, D.P.

    2008-01-01

    Most global energy models are developed by institutes from developed countries, focusing primarily on issues that are important in industrialized countries. Evaluation of the results for Asia of the IPCC/SRES models shows that broad concepts of energy and development, the energy ladder and the

  15. Improvement of Product Innovations Development Models

    Directory of Open Access Journals (Sweden)

    Rolandas Strazdas

    2011-03-01

    Full Text Available Many authors distinguish product innovation as a key factor leading to long-term competitiveness of companies. This article analyses widely used product innovation development models and also models having distinguished features. The models are examined in the light of success factors for product innovation development discovered during the empirical studies. Based on the analysis the strengths and weaknesses of the models are identified which provide direction for further improvement. As a result of the study it is becoming clear that the analysed models are not properly consider the success factors such as corporate culture, top management involvement and product development strategy. In particular, attention is drawn to the fact that all models are designed for rather big companies having experience in product innovation development. Article in Lithuanian

  16. Model Driven Development of Data Sensitive Systems

    DEFF Research Database (Denmark)

    Olsen, Petur

    2014-01-01

    Model-driven development strives to use formal artifacts during the development process. Formal artifacts enables automatic analyses of some aspects of the system under development. This serves to increase the understanding of the (intended) behavior of the system as well as increasing error...... to the values of variables. This theses strives to improve model-driven development of such data-sensitive systems. This is done by addressing three research questions. In the first we combine state-based modeling and abstract interpretation, in order to ease modeling of data-sensitive systems, while allowing...... detection and pushing error detection to earlier stages of development. The complexity of modeling and the size of systems which can be analyzed is severely limited when introducing data variables. The state space grows exponentially in the number of variable and the domain size of the variables...

  17. Faculty Development Using the Situational Leadership Model.

    Science.gov (United States)

    Shaner, Michael C.

    1995-01-01

    The situational leadership model developed by Hersey and Blanchard is described, and the task-specific model is then applied to the four primary tasks of college faculty--teaching, research, community service, and institutional service. The model combines directive and supportive behavior as they are reflected in four distinctive leadership…

  18. Development of a generalized integral jet model

    DEFF Research Database (Denmark)

    Duijm, Nijs Jan; Kessler, A.; Markert, Frank

    2017-01-01

    and decay of a jet of flammable gas after a release from a pressure container. The intention is to transfer the stationary models to a fully transient model, capable to predict the maximum extension of short-duration, high pressure jets. The model development is supported by conducting a set of transient...... requirements still limit the number of scenarios that can be dealt with using CFD only. The integral models, however, are not suited to handle transient releases, such as releases from pressurized equipment, where the initially high release rate decreases rapidly with time. Further, on gas ignition, a second...... model is needed to describe the rapid combustion of the flammable part of the plume (flash fire) and a third model has to be applied for the remaining jet fire. The objective of this paper is to describe the first steps of the development of an integral-type model describing the transient development...

  19. Developing a Domain Model for Relay Circuits

    DEFF Research Database (Denmark)

    Haxthausen, Anne Elisabeth

    2009-01-01

    In this paper we stepwise develop a domain model for relay circuits as used in railway control systems. First we provide an abstract, property-oriented model of networks consisting of components that can be glued together with connectors. This model is strongly inspired by a network model...... for railways madeby Bjørner et.al., however our model is more general: the components can be of any kind and can later be refined to e.g. railway components or circuit components. Then we show how the abstract network model can be refined into an explicit model for relay circuits. The circuit model describes...... the statics as well as the dynamics of relay circuits, i.e. how a relay circuit can be composed legally from electrical components as well as how the components may change state over time. Finally the circuit model is transformed into an executable model, and we show how a concrete circuit can be defined...

  20. Development of mathematical models of environmental physiology

    Science.gov (United States)

    Stolwijk, J. A. J.; Mitchell, J. W.; Nadel, E. R.

    1971-01-01

    Selected articles concerned with mathematical or simulation models of human thermoregulation are presented. The articles presented include: (1) development and use of simulation models in medicine, (2) model of cardio-vascular adjustments during exercise, (3) effective temperature scale based on simple model of human physiological regulatory response, (4) behavioral approach to thermoregulatory set point during exercise, and (5) importance of skin temperature in sweat regulation.

  1. Model based development of engine control algorithms

    NARCIS (Netherlands)

    Dekker, H.J.; Sturm, W.L.

    1996-01-01

    Model based development of engine control systems has several advantages. The development time and costs are strongly reduced because much of the development and optimization work is carried out by simulating both engine and control system. After optimizing the control algorithm it can be executed

  2. An Aristotelian Model of Moral Development

    Science.gov (United States)

    Sanderse, Wouter

    2015-01-01

    Despite the Aristotelian renaissance in the philosophy of education, the development of virtue has not received much attention. This is unfortunate, because an attempt to draft an Aristotelian model of moral development can help philosophers to evaluate the contribution Aristotelian virtue ethics can make to our understanding of moral development,…

  3. [A staff development model in psychiatric nursing].

    Science.gov (United States)

    Koen, D; Muller, M; Poggenpoel, M

    1995-03-01

    The nursing service manager is accountable for the quality of nursing care delivered in the nursing service. It is therefore important that the nursing service manager facilitates staff development in the nursing service. It is not only the nursing service manager's responsibility to make provision for staff development--the nurse also has a responsibility in this regard. He/she should purposefully make an effort to keep up to date with the latest developments. This article focuses on the co-responsibility of the psychiatric nurse and nursing service manager regarding staff development. A model for staff development is described, in accordance with the guidelines of Dickoff, James & Wiedenbach for theory development. An inductive approach was primarily followed to describe the provisional model, after which a literature study was employed to refine and purify the model. This model was exposed to expert evaluation, after which the final model for staff development of psychiatric nurses was described. Recommendations include the testing of certain hypotheses and utilisation of this model in psychiatric nursing practice.

  4. Developing Phenomena Models from Experimental Data

    DEFF Research Database (Denmark)

    Kristensen, Niels Rode; Madsen, Henrik; Jørgensen, Sten Bay

    2003-01-01

    unknown functionality behind various phenomena in first engineering principles models using experimental data. The proposed modelling approach has significant application potential, e.g. for determining unknown reaction kinetics in both chemical and biological processes. To illustrate the performance......A systematic approach for developing phenomena models from experimental data is presented. The approach is based on integrated application of stochastic differential equation (SDE) modelling and multivariate nonparametric regression, and it is shown how these techniques can be used to uncover...... of the approach, a case study is presented, which shows how an appropriate phenomena model for the growth rate of biomass in a fed-batch bioreactor can be inferred from data....

  5. Developing Phenomena Models from Experimental Data

    DEFF Research Database (Denmark)

    unknown functionality behind various phenomena in first engineering principles models using experimental data. The proposed modelling approach has significant application potential, e.g. for determining unknown reaction kinetics in both chemical and biological processes. To illustrate the performance......A systematic approach for developing phenomena models from experimental data is presented. The approach is based on integrated application of stochastic differential equation (SDE) modelling and multivariate nonparametric regression, and it is shown how these techniques can be used to uncover...... of the approach, a case study is presented, which shows how an appropriate phenomena model for the growth rate of biomass in a fed-batch bioreactor can be inferred from data....

  6. Network Models for Cognitive Development and Intelligence

    National Research Council Canada - National Science Library

    van der Maas, H.L.J; Kan, K.J; Marsman, M; Stevenson, C.E

    2017-01-01

    ... (dimensionality of individual differences). The welcome integration of the two fields requires the construction of mechanistic models of cognition and cognitive development that explain key phenomena in individual differences research...

  7. Gene Regulation Networks for Modeling Drosophila Development

    Science.gov (United States)

    Mjolsness, E.

    1999-01-01

    This chapter will very briefly introduce and review some computational experiments in using trainable gene regulation network models to simulate and understand selected episodes in the development of the fruit fly, Drosophila Melanogaster.

  8. Sectioning Clay Models Makes Anatomy & Development Tangible

    Science.gov (United States)

    Howell, Carina Endres; Howell, James Endres

    2010-01-01

    Clay models have proved to be useful teaching aids for many topics in biology that depend on three-dimensional reasoning. Students studying embryonic development struggle to mentally reconstruct the three-dimensional structure of embryos and larvae by observing prepared slides of cross-sectional slices. Students who build clay models of embryos…

  9. A Development Systems Model for Early Intervention.

    Science.gov (United States)

    Guralnick, Michael J.

    2001-01-01

    A rationale for and components of a development systems model are presented to guide early intervention programs. Core principles emphasizing a developmental framework, integration, and inclusion are expressed in the context of a multicomponent interactive system. The model's focus on maximizing family patterns of interaction by addressing…

  10. MODELS OF TOURIST DEVELOPMENT IN THE CONTEXT OF REGIONAL DEVELOPMENT

    Directory of Open Access Journals (Sweden)

    Borma Afrodita

    2012-07-01

    Full Text Available Third year PhD candidate at the University of Oradea, under the guidance of Professor Mrs. Alina Bădulescu in the doctoral research project entitled: "Doctoral studies and Ph.D. candidates for competitive research on a knowledge based society", a co-financed project by the European Social Fund through the Sectoral Operational Program for Human Resources Development 2007 - 2013, Priority Axis 1. "Education and training in support for growth and development of a knowledge based society" I chose to present this subject in order to demonstrate the connection that exists between tourism and regional development. Having as research topic "Tourism and development in the Euro regional context” I felt it would be appropriate to devote a subchapter in presenting the impact of tourism in regional development. Thus I have analysed a number of specialised papers found at national and international level in order to achieve a synthesis on the approached topic. Authors such as Williams and Shaw (1991, Sharma (2004, Keskin and Cansiz (2010 were concerned with presenting the positive aspects of tourism in regional development. Condes (2004 presents on one hand the secrets regarding success in matter of tourist development, and on the other side he presents the possible risks that follow the development of tourism in a country / region (Condes 2004. Following the gathered information we found that indeed tourism plays an important role in regional development. The used research methodology consisted in using specialised literature in order to identify some models that illustrate the potential success of tourism in regional development. The space-temporal development model of tourism proposed by Opperman (1993, although it was developed at national level represents a useful tool in illustrating the potential success of tourism in regional development. Miossec's model (Sharma 2004:300 describes the structural evolution of touristic regions in

  11. A Generic Modeling Process to Support Functional Fault Model Development

    Science.gov (United States)

    Maul, William A.; Hemminger, Joseph A.; Oostdyk, Rebecca; Bis, Rachael A.

    2016-01-01

    Functional fault models (FFMs) are qualitative representations of a system's failure space that are used to provide a diagnostic of the modeled system. An FFM simulates the failure effect propagation paths within a system between failure modes and observation points. These models contain a significant amount of information about the system including the design, operation and off nominal behavior. The development and verification of the models can be costly in both time and resources. In addition, models depicting similar components can be distinct, both in appearance and function, when created individually, because there are numerous ways of representing the failure space within each component. Generic application of FFMs has the advantages of software code reuse: reduction of time and resources in both development and verification, and a standard set of component models from which future system models can be generated with common appearance and diagnostic performance. This paper outlines the motivation to develop a generic modeling process for FFMs at the component level and the effort to implement that process through modeling conventions and a software tool. The implementation of this generic modeling process within a fault isolation demonstration for NASA's Advanced Ground System Maintenance (AGSM) Integrated Health Management (IHM) project is presented and the impact discussed.

  12. Continuous Competence Development Model for Teacher Teams

    DEFF Research Database (Denmark)

    Weitze, Charlotte Lærke

    2014-01-01

    practice enabling the teacher team to reflect, innovate and create. The model also provided teachers with thinking and acting technologies enabling change and the opportunity to anchor knowledge and locate new solutions for the frequent IT‐pedagogical issues on a theoretical and practical level......"This paper presents the development of the IT‐Pedagogical Think Tank for Teacher Teams (ITP4T), a continuous competence development model. The model was co‐designed following a design‐based research approach with teachers from VUC Storstrøm’s (VUC) Global Classroom (GC), an innovative hybrid...

  13. Models with Simultaneous Equations for Local Development

    Directory of Open Access Journals (Sweden)

    Ani MATEI

    2010-01-01

    Full Text Available This paper presents a model based on simultaneous equations with statistical determined parameters for describing the evolution of important issues relating to local development. The main issues considered are public and private business development environment, employment, demography, social comfort, etc. Parameter estimation with simultaneous equations model was done by procedures implemented in EViews using empirical data sets from city Braila, Romania, for the period 2000 to 2005. Applying the Durbin-Watson test, results were compared for the simultaneous equations model where the parameters were estimated by twostage least squares method.

  14. MODEL DRIVEN DEVELOPMENT OF ONLINE BANKING SYSTEMS

    Directory of Open Access Journals (Sweden)

    Bresfelean Vasile Paul

    2011-07-01

    Full Text Available In case of online applications the cycle of software development varies from the routine. The online environment, the variety of users, the treatability of the mass of information created by them, the reusability and the accessibility from different devices are all factors of these systems complexity. The use of model drive approach brings several advantages that ease up the development process. Working prototypes that simplify client relationship and serve as the base of model tests can be easily made from models describing the system. These systems make possible for the banks clients to make their desired actions from anywhere. The user has the possibility of accessing information or making transactions.

  15. Professional Development: A Learning Centered Model.

    Science.gov (United States)

    Geller, William W.

    A professional development model is proposed that is based on learning outcomes derived from Bloom's Taxonomy of Intellectual Inquiry. Professional development is depicted as a sequence of learning components: (1) broadened knowledge and comprehension; (2) improved application of that knowledge; and (3) an analysis, synthesis, and evaluation of…

  16. Conceptualizing Evolving Models of Educational Development

    Science.gov (United States)

    Fraser, Kym; Gosling, David; Sorcinelli, Mary Deane

    2010-01-01

    Educational development, which the authors use to refer to the field of professional and strategic development associated with university and college learning and teaching, can be described in many ways by referring to its different aspects. In this article the authors endeavor to categorize many of the models that have been used to describe…

  17. A career roles model of career development

    NARCIS (Netherlands)

    Hoekstra, Hans A.

    Career development is described as the interactive progression of internal career identity formation and the growth of external career significance. Argued is the need for a content model of career development where the field is dominated by process theories. A theory is put forward of career

  18. An Innovative Model for Professional Development

    Science.gov (United States)

    McMurray, Sharon; O'Neill, Susan; Thompson, Ross

    2016-01-01

    This paper considers an innovative model of continuing professional development in addressing the needs of children with literacy difficulties, namely the Special Educational Needs Continuing Professional Development Literacy Project. Stranmillis University College, in partnership with St Mary's University College, Belfast secured £4.06 million…

  19. Suitability of Modern Software Development Methodologies for Model Driven Development

    Directory of Open Access Journals (Sweden)

    Ruben Picek

    2009-12-01

    Full Text Available As an answer to today’s growing challenges in software industry, wide spectrum of new approaches of software development has occurred. One prominent direction is currently most promising software development paradigm called Model Driven Development (MDD. Despite a lot of skepticism and problems, MDD paradigm is being used and improved to accomplish many inherent potential benefits. In the methodological approach of software development it is necessary to use some kind of development process. Modern methodologies can be classified into two main categories: formal or heavyweight and agile or lightweight. But when it is a question about MDD and development process for MDD, currently known methodologies are very poor or better said they don't have any explanation of MDD process. As the result of research, in this paper, author examines the possibilities of using existing modern software methodologies in context of MDD paradigm.

  20. Sustainable development model for nautical tourism ports

    OpenAIRE

    Alen Jugović; Mirjana Kovačić; Ana Hadžić

    2011-01-01

    Nautical tourism ports make an open, dynamic and complex system which has been rapidly evolving; this is the reason why the development of this system requires continual monitoring and research. The existing models and development plans concerning nautical tourism ports do not provide for a systematic qualitative and quantitative development of nautical tourism, thus contributing to economical inefficiency likely to cause even ecological imbalance. The more so if nautical ports are regarded a...

  1. Development of NASA's Models and Simulations Standard

    Science.gov (United States)

    Bertch, William J.; Zang, Thomas A.; Steele, Martin J.

    2008-01-01

    From the Space Shuttle Columbia Accident Investigation, there were several NASA-wide actions that were initiated. One of these actions was to develop a standard for development, documentation, and operation of Models and Simulations. Over the course of two-and-a-half years, a team of NASA engineers, representing nine of the ten NASA Centers developed a Models and Simulation Standard to address this action. The standard consists of two parts. The first is the traditional requirements section addressing programmatics, development, documentation, verification, validation, and the reporting of results from both the M&S analysis and the examination of compliance with this standard. The second part is a scale for evaluating the credibility of model and simulation results using levels of merit associated with 8 key factors. This paper provides an historical account of the challenges faced by and the processes used in this committee-based development effort. This account provides insights into how other agencies might approach similar developments. Furthermore, we discuss some specific applications of models and simulations used to assess the impact of this standard on future model and simulation activities.

  2. Modeling socioeconomic status effects on language development.

    Science.gov (United States)

    Thomas, Michael S C; Forrester, Neil A; Ronald, Angelica

    2013-12-01

    Socioeconomic status (SES) is an important environmental predictor of language and cognitive development, but the causal pathways by which it operates are unclear. We used a computational model of development to explore the adequacy of manipulations of environmental information to simulate SES effects in English past-tense acquisition, in a data set provided by Bishop (2005). To our knowledge, this is the first application of computational models of development to SES. The simulations addressed 3 new challenges: (a) to combine models of development and individual differences in a single framework, (b) to expand modeling to the population level, and (c) to implement both environmental and genetic/intrinsic sources of individual differences. The model succeeded in capturing the qualitative patterns of regularity effects in both population performance and the predictive power of SES that were observed in the empirical data. The model suggested that the empirical data are best captured by relatively wider variation in learning abilities and relatively narrow variation in (and good quality of) environmental information. There were shortcomings in the model's quantitative fit, which are discussed. The model made several novel predictions, with respect to the influence of SES on delay versus giftedness, the change of SES effects over development, and the influence of SES on children of different ability levels (gene-environment interactions). The first of these predictions was that SES should reliably predict gifted performance in children but not delayed performance, and the prediction was supported by the Bishop data set. Finally, the model demonstrated limits on the inferences that can be drawn about developmental mechanisms on the basis of data from individual differences. PsycINFO Database Record (c) 2013 APA, all rights reserved.

  3. Modelling the canopy development of bambara groundnut

    DEFF Research Database (Denmark)

    Karunaratne, A.S.; Azam-Ali, S.N.; Al-Shareef, I.

    2010-01-01

    Canopy development of bambara groundnut (Vigna subterranea (L.) Verdc) is affected by temperature stress, drought stress and photoperiod. The quantification of these documented effects by means of a suitable crop model, BAMGRO is presented in this paper. Data on canopy development from five growth...... and drought stress. The leaf area expansion is calculated as a function of leaf number and individual leaf size. The canopy development of bambara groundnut is modelled (and tested) in BAMGRO model by means of leaf initiation and leaf area expansion and branching and stem production are not considered. Nash.......80) with maximum MAE less than ±0.50 thus explaining canopy development under temperature stress, drought stress and variable photoperiods....

  4. Model Development for Scientific Data Curation Education

    Directory of Open Access Journals (Sweden)

    Karon Kelly

    2013-06-01

    Full Text Available The mounting and critical need for scientific data curation professionals was the impetus for the Data Curation Education in Research Centers (DCERC program. DCERC is developing a sustainable and transferable model for educating Library and Information Science (LIS students in data curation through field experiences in research and data centers. DCERC has established and implemented a graduate research and education program bringing students into the real world of scientific data curation, where they engage with current practices and challenges, and share their developing expertise and research. The DCERC partner institutions are developing and evaluating this model with the intention of scaling the program to a larger cadre of partners and participants. This paper reports on progress in the early phases of the model development.

  5. Development of Ensemble Model Based Water Demand Forecasting Model

    Science.gov (United States)

    Kwon, Hyun-Han; So, Byung-Jin; Kim, Seong-Hyeon; Kim, Byung-Seop

    2014-05-01

    In recent years, Smart Water Grid (SWG) concept has globally emerged over the last decade and also gained significant recognition in South Korea. Especially, there has been growing interest in water demand forecast and optimal pump operation and this has led to various studies regarding energy saving and improvement of water supply reliability. Existing water demand forecasting models are categorized into two groups in view of modeling and predicting their behavior in time series. One is to consider embedded patterns such as seasonality, periodicity and trends, and the other one is an autoregressive model that is using short memory Markovian processes (Emmanuel et al., 2012). The main disadvantage of the abovementioned model is that there is a limit to predictability of water demands of about sub-daily scale because the system is nonlinear. In this regard, this study aims to develop a nonlinear ensemble model for hourly water demand forecasting which allow us to estimate uncertainties across different model classes. The proposed model is consist of two parts. One is a multi-model scheme that is based on combination of independent prediction model. The other one is a cross validation scheme named Bagging approach introduced by Brieman (1996) to derive weighting factors corresponding to individual models. Individual forecasting models that used in this study are linear regression analysis model, polynomial regression, multivariate adaptive regression splines(MARS), SVM(support vector machine). The concepts are demonstrated through application to observed from water plant at several locations in the South Korea. Keywords: water demand, non-linear model, the ensemble forecasting model, uncertainty. Acknowledgements This subject is supported by Korea Ministry of Environment as "Projects for Developing Eco-Innovation Technologies (GT-11-G-02-001-6)

  6. Development of an Irrigation Scheduling Model

    Directory of Open Access Journals (Sweden)

    BAKHSHAL KHAN LASHARI

    2010-10-01

    Full Text Available This paper presents an irrigation scheduling software named ?Mehran Model? which computes reference evapotranspiration (ETo using FAO-56 Penman Monteith method and crop evapotranspiration (ETc by dual crop coefficients. The model can develop irrigation schedules for sixty-six crop types using soil and water balance approach. The model distinguishes soil texture classes, irrigation methods, and designs real time irrigation schedule for a crop using daily weather data of a reference site. The Mehran Model also includes planning on demand basis as well as rotational (warabandi irrigation schedules, and synchronizes both systems as well. The model has been field tested and validated on planning and management of irrigation schedules for cotton and wheat crops in Lower Indus Basin of Pakistan. Statistical analysis showed that the model at an average overestimated seasonal ETc of cotton and wheat crop by 2.41% and 4.31% respectively.

  7. DEVELOPMENT MODEL OF UNDER DEVELOPED SMALL ISLAND IN SUMENEP

    Directory of Open Access Journals (Sweden)

    Sudarti Sudarti

    2011-09-01

    Full Text Available The purpose of this study is to build a Geographic Information System and Management Information System models of development of small islands in Sumenep. Based on the identification of economic potential there are few regions such as Nonggunong, Gayam, Ra'as, and Sapeken which have large contribution toward the rice plant production. The whole districts of the islands in Sumenep are the base of cow, horse, chicken and livestock commodities. Sapeken have significant contribution for marine fish. Giligenting, Nonggunong, Gayam, and Arjasa have large potential for brackish fish. Moreover, Gili-genting also has a great contribution for fresh fish.Keywords: Development model, under-developed area, small islandsJEL classification numbers: O13, O14

  8. Kinetics model development of cocoa bean fermentation

    Science.gov (United States)

    Kresnowati, M. T. A. P.; Gunawan, Agus Yodi; Muliyadini, Winny

    2015-12-01

    Although Indonesia is one of the biggest cocoa beans producers in the world, Indonesian cocoa beans are oftenly of low quality and thereby frequently priced low in the world market. In order to improve the quality, adequate post-harvest cocoa processing techniques are required. Fermentation is the vital stage in series of cocoa beans post harvest processing which could improve the quality of cocoa beans, in particular taste, aroma, and colours. During the fermentation process, combination of microbes grow producing metabolites that serve as the precursors for cocoa beans flavour. Microbial composition and thereby their activities will affect the fermentation performance and influence the properties of cocoa beans. The correlation could be reviewed using a kinetic model that includes unstructured microbial growth, substrate utilization and metabolic product formation. The developed kinetic model could be further used to design cocoa bean fermentation process to meet the expected quality. Further the development of kinetic model of cocoa bean fermentation also serve as a good case study of mixed culture solid state fermentation, that has rarely been studied. This paper presents the development of a kinetic model for solid-state cocoa beans fermentation using an empirical approach. Series of lab scale cocoa bean fermentations, either natural fermentations without starter addition or fermentations with mixed yeast and lactic acid bacteria starter addition, were used for model parameters estimation. The results showed that cocoa beans fermentation can be modelled mathematically and the best model included substrate utilization, microbial growth, metabolites production and its transport. Although the developed model still can not explain the dynamics in microbial population, this model can sufficiently explained the observed changes in sugar concentration as well as metabolic products in the cocoa bean pulp.

  9. Development of the Integrated Environmental Control Model

    Energy Technology Data Exchange (ETDEWEB)

    Rubin, E.S.; Berkenpas, M.B.; Kalagnanam, J.

    1993-04-01

    The purpose of this contract is to develop and refine the Integrated Environmental Control Model (IECM) created and enhanced by Carnegie Mellon University (CMU) for the US Department of Energy's Pittsburgh Energy Technology Center (DOE/PETC) under contract Numbers FG22-83PC60271 and AC22-87PC79864. In its current configuration, the IECM provides a capability to model various conventional and advanced processes for controlling air pollutant emissions from coal-fired power plants before, during, or after combustion. The principal purpose of the model is to calculate the performance, emissions, and cost of power plant configurations employing alternative environmental control methods. The model consists of various control technology modules, which may be integrated into a complete utility plant in any desired combination. In contrast to conventional deterministic models, the IECM offers the unique capability to assign probabilistic values to all model input parameters, and to obtain probabilistic outputs in the form of cumulative distribution functions indicating the likelihood of different costs and performance results. The work in this contract is divided into two phases. Phase I deals with further developing the existing version of the IECM and training PETC personnel on the effective use of the model. Phase II deals with creating new technology modules, linking the IECM with PETC databases, and training PETC personnel on the effective use of the updated model.

  10. JEDI: Jobs and Economic Development Impact Model

    Energy Technology Data Exchange (ETDEWEB)

    2017-06-13

    The Jobs and Economic Development Impact (JEDI) models are user-friendly tools that estimate the economic impacts of constructing and operating power generation and biofuel plants at the local (usually state) level. First developed by NREL's researchers to model wind energy jobs and impacts, JEDI has been expanded to also estimate the economic impacts of biofuels, coal, conventional hydro, concentrating solar power, geothermal, marine and hydrokinetic power, natural gas, photovoltaics, and transmission lines. This fact sheet focuses on JEDI for wind energy projects and is revised with 2017 figures.

  11. Development and validation of model for sand

    Directory of Open Access Journals (Sweden)

    Church P.

    2015-01-01

    Full Text Available There is a growing requirement within QinetiQ to develop models for assessments when there is very little experimental data. A theoretical approach to developing equations of state for geological materials has been developed using Quantitative Structure Property Modelling based on the Porter-Gould model approach. This has been applied to well-controlled sand with different moisture contents and particle shapes. The Porter-Gould model describes an elastic response and gives good agreement at high impact pressures with experiment indicating that the response under these conditions is dominated by the molecular response. However at lower pressures the compaction behaviour is dominated by a micro-mechanical response which drives the need for additional theoretical tools and experiments to separate the volumetric and shear compaction behaviour. The constitutive response is fitted to existing triaxial cell data and Quasi-Static (QS compaction data. This data is then used to construct a model in the hydrocode. The model shows great promise in predicting plate impact, Hopkinson bar, fragment penetration and residual velocity of fragments through a finite thickness of sand.

  12. Model-Driven Development of Safety Architectures

    Science.gov (United States)

    Denney, Ewen; Pai, Ganesh; Whiteside, Iain

    2017-01-01

    We describe the use of model-driven development for safety assurance of a pioneering NASA flight operation involving a fleet of small unmanned aircraft systems (sUAS) flying beyond visual line of sight. The central idea is to develop a safety architecture that provides the basis for risk assessment and visualization within a safety case, the formal justification of acceptable safety required by the aviation regulatory authority. A safety architecture is composed from a collection of bow tie diagrams (BTDs), a practical approach to manage safety risk by linking the identified hazards to the appropriate mitigation measures. The safety justification for a given unmanned aircraft system (UAS) operation can have many related BTDs. In practice, however, each BTD is independently developed, which poses challenges with respect to incremental development, maintaining consistency across different safety artifacts when changes occur, and in extracting and presenting stakeholder specific information relevant for decision making. We show how a safety architecture reconciles the various BTDs of a system, and, collectively, provide an overarching picture of system safety, by considering them as views of a unified model. We also show how it enables model-driven development of BTDs, replete with validations, transformations, and a range of views. Our approach, which we have implemented in our toolset, AdvoCATE, is illustrated with a running example drawn from a real UAS safety case. The models and some of the innovations described here were instrumental in successfully obtaining regulatory flight approval.

  13. Argonne Bubble Experiment Thermal Model Development

    Energy Technology Data Exchange (ETDEWEB)

    Buechler, Cynthia Eileen [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-12-03

    This report will describe the Computational Fluid Dynamics (CFD) model that was developed to calculate the temperatures and gas volume fractions in the solution vessel during the irradiation. It is based on the model used to calculate temperatures and volume fractions in an annular vessel containing an aqueous solution of uranium . The experiment was repeated at several electron beam power levels, but the CFD analysis was performed only for the 12 kW irradiation, because this experiment came the closest to reaching a steady-state condition. The aim of the study is to compare results of the calculation with experimental measurements to determine the validity of the CFD model.

  14. Development of a simplified biofilm model

    Science.gov (United States)

    Sarkar, Sushovan; Mazumder, Debabrata

    2017-07-01

    A simplified approach for analyzing the biofilm process in deriving an easy model has been presented. This simplified biofilm model formulated correlations between substrate concentration in the influent/effluent and at biofilm-liquid interface along with substrate flux and biofilm thickness. The model essentially considered the external mass transport according to Fick's Law, steady state substrate as well as biomass balance for attached growth microorganisms. In substrate utilization, Monod growth kinetics has been followed incorporating relevant boundary conditions at the liquid-biofilm interface and at the attachment surface. The numerical solution of equations was accomplished using Runge-Kutta method and accordingly an integrated computer program was developed. The model has been successfully applied in a distinct set of trials with varying range of representative input variables. The model performance was compared with available existing methods and it was found an easy, accurate method that can be used for process design of biofilm reactor.

  15. Development of Model for Providing Feasible Scholarship

    Directory of Open Access Journals (Sweden)

    Harry Dhika

    2016-05-01

    Full Text Available The current work focuses on the development of a model to determine a feasible scholarship recipient on the basis of the naiv¨e Bayes’ method using very simple and limited attributes. Those attributes are the applicants academic year, represented by their semester, academic performance, represented by their GPa, socioeconomic ability, which represented the economic capability to attend a higher education institution, and their level of social involvement. To establish and evaluate the model performance, empirical data are collected, and the data of 100 students are divided into 80 student data for the model training and the remaining of 20 student data are for the model testing. The results suggest that the model is capable to provide recommendations for the potential scholarship recipient at the level of accuracy of 95%.

  16. Ion channel model development and validation

    Science.gov (United States)

    Nelson, Peter Hugo

    2010-03-01

    The structure of the KcsA ion channel selectivity filter is used to develop three simple models of ion channel permeation. The quantitative predictions of the knock-on model are tested by comparison with experimental data from single-channel recordings of the KcsA channel. By comparison with experiment, students discover that the knock-on model can't explain saturation of ion channel current as the concentrations of the bathing solutions are increased. By inverting the energy diagram, students derive the association-dissociation model of ion channel permeation. This model predicts non-linear Michaelis-Menten saturating behavior that requires students to perform non-linear least-squares fits to the experimental data. This is done using Excel's solver feature. Students discover that this simple model does an excellent job of explaining the qualitative features of ion channel permeation but cannot account for changes in voltage sensitivity. The model is then extended to include an electrical dissociation distance. This rapid translocation model is then compared with experimental data from a wide variety of ion channels and students discover that this model also has its limitations. Support from NSF DUE 0836833 is gratefully acknowledged.

  17. Status report on dissolution model development

    Energy Technology Data Exchange (ETDEWEB)

    Jackson, D.D.

    1983-07-01

    The computer program PROTOCOL models the dissolution reactions of chemical species in water. It is being developed particularly to study the dissolution of proposed nuclear waste forms and related phases. Experimentally derived leaching rate functions are coupled to thermochemical equilibrium calculations and water flow rates. The program has been developed over a period of years. This report describes improvements that have been done in the past year.

  18. Fully Adaptive Radar Modeling and Simulation Development

    Science.gov (United States)

    2017-04-01

    have developed a MATLAB-based modeling and simulation (M&S) architecture for distributed fully adaptive radar (FAR) that will enable algorithm...development and testing on simulated, previously collected, and real-time streaming data. The architecture is coded in MATLAB using an object oriented...programming approach. The architecture includes a FAR engine to control the operation of the perception-action cycle and software objects that determine the

  19. Development modeling of Lucilia sericata (Diptera: Calliphoridae).

    Science.gov (United States)

    Roe, Amanda; Higley, Leon G

    2015-01-01

    The relationship between insect development and temperature has been well established and has a wide range of uses, including the use of blow flies for postmortem (PMI) interval estimations in death investigations. To use insects in estimating PMI, we must be able to determine the insect age at the time of discovery and backtrack to time of oviposition. Unfortunately, existing development models of forensically important insects are only linear approximations and do not take into account the curvilinear properties experienced at extreme temperatures. A series of experiments were conducted with Lucilia sericata, a forensically important blow fly species, that met the requirements needed to create statistically valid development models. Experiments were conducted over 11 temperatures (7.5 to 32.5 °C, at 2.5 °C) with a 16:8 L:D cycle. Experimental units contained 20 eggs, 10 g beef liver, and 2.5 cm of pine shavings. Each life stage (egg to adult) had five sampling times. Each sampling time was replicated four times, for a total of 20 measurements per life stage. For each sampling time, the cups were pulled from the chambers and the stage of each maggot was documented morphologically through posterior spiracle slits and cephalopharyngeal skeletal development. Data were normally distributed with the later larval stages (L3f, L3m) having the most variation within and transitioning between stages. The biological minimum was between 7.5 °C and 10 °C, with little egg development and no egg emergence at 7.5 °C. Temperature-induced mortality was highest from 10.0 to 17.5 °C and 32.5 °C. The development data generated illustrates the advantages of large datasets in modeling Lucilia sericata development and the need for curvilinear models in describing development at environmental temperatures near the biological minima and maxima.

  20. Development modeling of Lucilia sericata (Diptera: Calliphoridae

    Directory of Open Access Journals (Sweden)

    Amanda Roe

    2015-03-01

    Full Text Available The relationship between insect development and temperature has been well established and has a wide range of uses, including the use of blow flies for postmortem (PMI interval estimations in death investigations. To use insects in estimating PMI, we must be able to determine the insect age at the time of discovery and backtrack to time of oviposition. Unfortunately, existing development models of forensically important insects are only linear approximations and do not take into account the curvilinear properties experienced at extreme temperatures. A series of experiments were conducted with Lucilia sericata, a forensically important blow fly species, that met the requirements needed to create statistically valid development models. Experiments were conducted over 11 temperatures (7.5 to 32.5 °C, at 2.5 °C with a 16:8 L:D cycle. Experimental units contained 20 eggs, 10 g beef liver, and 2.5 cm of pine shavings. Each life stage (egg to adult had five sampling times. Each sampling time was replicated four times, for a total of 20 measurements per life stage. For each sampling time, the cups were pulled from the chambers and the stage of each maggot was documented morphologically through posterior spiracle slits and cephalopharyngeal skeletal development. Data were normally distributed with the later larval stages (L3f, L3m having the most variation within and transitioning between stages. The biological minimum was between 7.5 °C and 10 °C, with little egg development and no egg emergence at 7.5 °C. Temperature-induced mortality was highest from 10.0 to 17.5 °C and 32.5 °C. The development data generated illustrates the advantages of large datasets in modeling Lucilia sericata development and the need for curvilinear models in describing development at environmental temperatures near the biological minima and maxima.

  1. Development of an Integrated Global Energy Model

    Energy Technology Data Exchange (ETDEWEB)

    Krakowski, R.A.

    1999-07-08

    The primary objective of this research was to develop a forefront analysis tool for application to enhance understanding of long-term, global, nuclear-energy and nuclear-material futures. To this end, an existing economics-energy-environmental (E{sup 3}) model was adopted, modified, and elaborated to examine this problem in a multi-regional (13), long-term ({approximately}2,100) context. The E{sup 3} model so developed was applied to create a Los Alamos presence in this E{sup 3} area through ''niche analyses'' that provide input to the formulation of policies dealing with and shaping of nuclear-energy and nuclear-materials futures. Results from analyses using the E{sup 3} model have been presented at a variety of national and international conferences and workshops. Through use of the E{sup 3} model Los Alamos was afforded the opportunity to participate in a multi-national E{sup 3} study team that is examining a range of global, long-term nuclear issues under the auspices of the IAEA during the 1998-99 period . Finally, the E{sup 3} model developed under this LDRD project is being used as an important component in more recent Nuclear Material Management Systems (NMMS) project.

  2. Energy and development : A modelling approach

    NARCIS (Netherlands)

    van Ruijven, B.J.|info:eu-repo/dai/nl/304834521

    2008-01-01

    Rapid economic growth of developing countries like India and China implies that these countries become important actors in the global energy system. Examples of this impact are the present day oil shortages and rapidly increasing emissions of greenhouse gases. Global energy models are used explore

  3. Mechanical Model Development for Composite Structural Supercapacitors

    Science.gov (United States)

    Ricks, Trenton M.; Lacy, Thomas E., Jr.; Santiago, Diana; Bednarcyk, Brett A.

    2016-01-01

    Novel composite structural supercapacitor concepts have recently been developed as a means both to store electrical charge and to provide modest mechanical load carrying capability. Double-layer composite supercapacitors are often fabricated by impregnating a woven carbon fiber fabric, which serves as the electrodes, with a structural polymer electrolyte. Polypropylene or a glass fabric is often used as the separator material. Recent research has been primarily limited to evaluating these composites experimentally. In this study, mechanical models based on the Multiscale Generalized Method of Cells (MSGMC) were developed and used to calculate the shear and tensile properties and response of two composite structural supercapacitors from the literature. The modeling approach was first validated against traditional composite laminate data. MSGMC models for composite supercapacitors were developed, and accurate elastic shear/tensile properties were obtained. It is envisioned that further development of the models presented in this work will facilitate the design of composite components for aerospace and automotive applications and can be used to screen candidate constituent materials for inclusion in future composite structural supercapacitor concepts.

  4. DEVELOPMENT OF A MAINTENANCE SCHEDULING MODEL FOR ...

    African Journals Online (AJOL)

    This paper presents the development of an efficient method for use in obtaining the best time between coordinated overhauls for a group of machines. The method is capable of stating the overhaul frequency of each machine within this time period. For convenience in the formulation of the model, maintenance schedule ...

  5. A Computational Model of Spatial Development

    Science.gov (United States)

    Hiraki, Kazuo; Sashima, Akio; Phillips, Steven

    Psychological experiments on children's development of spatial knowledge suggest experience at self-locomotion with visual tracking as important factors. Yet, the mechanism underlying development is unknown. We propose a robot that learns to mentally track a target object (i.e., maintaining a representation of an object's position when outside the field-of-view) as a model for spatial development. Mental tracking is considered as prediction of an object's position given the previous environmental state and motor commands, and the current environment state resulting from movement. Following Jordan & Rumelhart's (1992) forward modeling architecture the system consists of two components: an inverse model of sensory input to desired motor commands; and a forward model of motor commands to desired sensory input (goals). The robot was tested on the `three cups' paradigm (where children are required to select the cup containing the hidden object under various movement conditions). Consistent with child development, without the capacity for self-locomotion the robot's errors are self-center based. When given the ability of self-locomotion the robot responds allocentrically.

  6. The Jeffrey Town Model for Community Development

    Science.gov (United States)

    Gordon, Ivy Veronica

    2014-01-01

    The Jeffrey Town model for community development has been effectively applied to the rural community of Jeffrey Town in Jamaica with Information and Computer Technology (ICT) as a key element. The farmer's association is the vehicle that has driven the change. Included is a brief outline of the community plus highlights of the tangible and…

  7. Developing a Motivational Model of College Achievement.

    Science.gov (United States)

    Tuckman, Bruce W.; Abry, Dennis

    This study involves developing a motivational model of college achievement. The predictor variables, which were procrastination tendency, self-efficacy, self-regulation, intrinsic value, outcome value, cognitive strategy, test anxiety, students grade goals, parent grade goals, and grade point average, as well as the criterion variable exam…

  8. Developing a TQM quality management method model

    NARCIS (Netherlands)

    Zhang, Zhihai

    1997-01-01

    From an extensive review of total quality management literature, the external and internal environment affecting an organization's quality performance and the eleven primary elements of TQM are identified. Based on the primary TQM elements, a TQM quality management method model is developed. This

  9. Model Driven Software Development for Agricultural Robotics

    DEFF Research Database (Denmark)

    Larsen, Morten

    The design and development of agricultural robots, consists of both mechan- ical, electrical and software components. All these components must be de- signed and combined such that the overall goal of the robot is fulfilled. The design and development of these systems require collaboration between...... processing, control engineering, etc. This thesis proposes a Model-Driven Software Develop- ment based approach to model, analyse and partially generate the software implementation of a agricultural robot. Furthermore, Guidelines for mod- elling the architecture of an agricultural robots are provided......, assisting with bridging the different engineering disciplines. Timing play an important role in agricultural robotic applications, synchronisation of robot movement and implement actions is important in order to achieve precision spraying, me- chanical weeding, individual feeding, etc. Discovering...

  10. Dengue human infection models supporting drug development.

    Science.gov (United States)

    Whitehorn, James; Van, Vinh Chau Nguyen; Simmons, Cameron P

    2014-06-15

    Dengue is a arboviral infection that represents a major global health burden. There is an unmet need for effective dengue therapeutics to reduce symptoms, duration of illness and incidence of severe complications. Here, we consider the merits of a dengue human infection model (DHIM) for drug development. A DHIM could allow experimentally controlled studies of candidate therapeutics in preselected susceptible volunteers, potentially using smaller sample sizes than trials that recruited patients with dengue in an endemic country. In addition, the DHIM would assist the conduct of intensive pharmacokinetic and basic research investigations and aid in determining optimal drug dosage. Furthermore, a DHIM could help establish proof of concept that chemoprophylaxis against dengue is feasible. The key challenge in developing the DHIM for drug development is to ensure the model reliably replicates the typical clinical and laboratory features of naturally acquired, symptomatic dengue. © The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America.

  11. Inducer analysis/pump model development

    Science.gov (United States)

    Cheng, Gary C.

    1994-01-01

    Current design of high performance turbopumps for rocket engines requires effective and robust analytical tools to provide design information in a productive manner. The main goal of this study was to develop a robust and effective computational fluid dynamics (CFD) pump model for general turbopump design and analysis applications. A finite difference Navier-Stokes flow solver, FDNS, which includes an extended k-epsilon turbulence model and appropriate moving zonal interface boundary conditions, was developed to analyze turbulent flows in turbomachinery devices. In the present study, three key components of the turbopump, the inducer, impeller, and diffuser, were investigated by the proposed pump model, and the numerical results were benchmarked by the experimental data provided by Rocketdyne. For the numerical calculation of inducer flows with tip clearance, the turbulence model and grid spacing are very important. Meanwhile, the development of the cross-stream secondary flow, generated by curved blade passage and the flow through tip leakage, has a strong effect on the inducer flow. Hence, the prediction of the inducer performance critically depends on whether the numerical scheme of the pump model can simulate the secondary flow pattern accurately or not. The impeller and diffuser, however, are dominated by pressure-driven flows such that the effects of turbulence model and grid spacing (except near leading and trailing edges of blades) are less sensitive. The present CFD pump model has been proved to be an efficient and robust analytical tool for pump design due to its very compact numerical structure (requiring small memory), fast turnaround computing time, and versatility for different geometries.

  12. Testing Software Development Project Productivity Model

    Science.gov (United States)

    Lipkin, Ilya

    Software development is an increasingly influential factor in today's business environment, and a major issue affecting software development is how an organization estimates projects. If the organization underestimates cost, schedule, and quality requirements, the end results will not meet customer needs. On the other hand, if the organization overestimates these criteria, resources that could have been used more profitably will be wasted. There is no accurate model or measure available that can guide an organization in a quest for software development, with existing estimation models often underestimating software development efforts as much as 500 to 600 percent. To address this issue, existing models usually are calibrated using local data with a small sample size, with resulting estimates not offering improved cost analysis. This study presents a conceptual model for accurately estimating software development, based on an extensive literature review and theoretical analysis based on Sociotechnical Systems (STS) theory. The conceptual model serves as a solution to bridge organizational and technological factors and is validated using an empirical dataset provided by the DoD. Practical implications of this study allow for practitioners to concentrate on specific constructs of interest that provide the best value for the least amount of time. This study outlines key contributing constructs that are unique for Software Size E-SLOC, Man-hours Spent, and Quality of the Product, those constructs having the largest contribution to project productivity. This study discusses customer characteristics and provides a framework for a simplified project analysis for source selection evaluation and audit task reviews for the customers and suppliers. Theoretical contributions of this study provide an initial theory-based hypothesized project productivity model that can be used as a generic overall model across several application domains such as IT, Command and Control

  13. Advanced Small Modular Reactor Economics Model Development

    Energy Technology Data Exchange (ETDEWEB)

    Harrison, Thomas J [ORNL

    2014-10-01

    The US Department of Energy Office of Nuclear Energy’s Advanced Small Modular Reactor (SMR) research and development activities focus on four key areas: Developing assessment methods for evaluating advanced SMR technologies and characteristics; and Developing and testing of materials, fuels and fabrication techniques; and Resolving key regulatory issues identified by US Nuclear Regulatory Commission and industry; and Developing advanced instrumentation and controls and human-machine interfaces. This report focuses on development of assessment methods to evaluate advanced SMR technologies and characteristics. Specifically, this report describes the expansion and application of the economic modeling effort at Oak Ridge National Laboratory. Analysis of the current modeling methods shows that one of the primary concerns for the modeling effort is the handling of uncertainty in cost estimates. Monte Carlo–based methods are commonly used to handle uncertainty, especially when implemented by a stand-alone script within a program such as Python or MATLAB. However, a script-based model requires each potential user to have access to a compiler and an executable capable of handling the script. Making the model accessible to multiple independent analysts is best accomplished by implementing the model in a common computing tool such as Microsoft Excel. Excel is readily available and accessible to most system analysts, but it is not designed for straightforward implementation of a Monte Carlo–based method. Using a Monte Carlo algorithm requires in-spreadsheet scripting and statistical analyses or the use of add-ons such as Crystal Ball. An alternative method uses propagation of error calculations in the existing Excel-based system to estimate system cost uncertainty. This method has the advantage of using Microsoft Excel as is, but it requires the use of simplifying assumptions. These assumptions do not necessarily bring into question the analytical results. In fact, the

  14. The development of a retroperitoneal dissection model.

    Science.gov (United States)

    Yousuf, Aisha A; Frecker, Helena; Satkunaratnam, Abheha; Shore, Eliane M

    2017-10-01

    Knowledge of ureteric anatomy is essential for ureteric injury prevention in laparoscopic gynecologic surgery. Rates of injury increase with limited surgical experience and reduced surgical volume. Currently, there are no low-fidelity or high-fidelity simulation models for teaching and practicing ureteric dissection. Our goal was to design a laparoscopic simulation model for retroperitoneal anatomy with high face validity that is low-cost and easily reproducible. A low-fidelity 3-dimensional simulation model was developed that represents key anatomic structures encountered during retroperitoneal dissection and ureteric identification. Materials, construction steps, and costs were determined. The models were trialed by expert laparoscopic surgeons. Demographic information that included age, gender, surgical experience, and complex laparoscopic case volumes was collected. Face validity was assessed with a 5-item Likert-scale. The total cost of 1 model ranged from $65 to $75. The majority of the materials that were used were reusable, except for 2 components that cost model resembled the texture of the ureter, vessels, and peritoneal layer (n=6; 86%), approximated the correct anatomic course of the ureter (n=7; 100%), and closely approximated live surgery (n=5; 71%). They also agreed or strongly agreed that the model would be useful for teaching laparoscopic retroperitoneal dissection (n=7; 100%), for assessing a learner's ability before performing in the operating room (n=6; 86%), was low-cost (n=7; 100%), and was easily reproducible (n=6; 86%). This unique model fills a gap in laparoscopic simulation training. No other low- or high-fidelity models for laparoscopic retroperitoneal ureteric dissection have been identified in the literature. This simulation model is low-cost, easily reproducible, closely resembles retroperitoneal dissection during laparoscopic gynecologic surgery, and can be used for education and assessment. Copyright © 2017 Elsevier Inc. All rights

  15. Heat Pump Clothes Dryer Model Development

    Energy Technology Data Exchange (ETDEWEB)

    Shen, Bo [ORNL

    2016-01-01

    A heat pump clothes dryer (HPCD) is an innovative appliance that uses a vapor compression system to dry clothes. Air circulates in a closed loop through the drum, so no vent is required. The condenser heats air to evaporate moisture out of the clothes, and the evaporator condenses water out of the air stream. As a result, the HPCD can achieve 50% energy savings compared to a conventional electric resistance dryer. We developed a physics-based, quasi-steady-state HPCD system model with detailed heat exchanger and compressor models. In a novel approach, we applied a heat and mass transfer effectiveness model to simulate the drying process of the clothes load in the drum. The system model is able to simulate the inherently transient HPCD drying process, to size components, and to reveal trends in key variables (e.g. compressor discharge temperature, power consumption, required drying time, etc.) The system model was calibrated using experimental data on a prototype HPCD. In the paper, the modeling method is introduced, and the model predictions are compared with experimental data measured on a prototype HPCD.

  16. Dynamics models and modeling of tree stand development

    Directory of Open Access Journals (Sweden)

    M. V. Rogozin

    2015-04-01

    Full Text Available Brief analysis of scientific works in Russia and in the CIS over the past 100 years. Logical and mathematical models consider the conceptual and show some of the results of their verification. It was found that the models include different laws and the parameters, the sum of which allows you to divide them into four categories: models of static states, development models, models of care for the natural forest and models of cultivation. Each category has fulfilled and fulfills its tasks in economic management. Thus, the model states in statics (table traverse growth played a prominent role in figuring out what may be the most productive (full stands in different regions of the country. However, they do not answer the question of what the initial states lead to the production of complete stands. In a study of the growth of stands used system analysis, and it is observed dominance of works studying static state, snatched from the biological time. Therefore, the real drama of the growth of stands remained almost unexplored. It is no accident there were «chrono-forestry» «plantation forestry» and even «non-traditional forestry», where there is a strong case of a number of new concepts of development stands. That is quite in keeping with Kuhn (Kuhn, 2009 in the forestry crisis began – there were alternative theories and coexist conflicting scientific schools. To develop models of stand development, it is proposed to use a well-known method of repeated observations within 10–20 years, in conjunction with the explanation of the history of the initial density. It mounted on the basis of studying the dynamics of its indicators: the trunk, crown overlap coefficient, the sum of volumes of all crowns and the relative length of the crown. According to these indicators, the researcher selects natural series of development stands with the same initial density. As a theoretical basis for the models it is possible to postulate the general properties of

  17. Preliminary Phase Field Computational Model Development

    Energy Technology Data Exchange (ETDEWEB)

    Li, Yulan [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Hu, Shenyang Y. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Xu, Ke [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Suter, Jonathan D. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); McCloy, John S. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Johnson, Bradley R. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Ramuhalli, Pradeep [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2014-12-15

    This interim report presents progress towards the development of meso-scale models of magnetic behavior that incorporate microstructural information. Modeling magnetic signatures in irradiated materials with complex microstructures (such as structural steels) is a significant challenge. The complexity is addressed incrementally, using the monocrystalline Fe (i.e., ferrite) film as model systems to develop and validate initial models, followed by polycrystalline Fe films, and by more complicated and representative alloys. In addition, the modeling incrementally addresses inclusion of other major phases (e.g., martensite, austenite), minor magnetic phases (e.g., carbides, FeCr precipitates), and minor nonmagnetic phases (e.g., Cu precipitates, voids). The focus of the magnetic modeling is on phase-field models. The models are based on the numerical solution to the Landau-Lifshitz-Gilbert equation. From the computational standpoint, phase-field modeling allows the simulation of large enough systems that relevant defect structures and their effects on functional properties like magnetism can be simulated. To date, two phase-field models have been generated in support of this work. First, a bulk iron model with periodic boundary conditions was generated as a proof-of-concept to investigate major loop effects of single versus polycrystalline bulk iron and effects of single non-magnetic defects. More recently, to support the experimental program herein using iron thin films, a new model was generated that uses finite boundary conditions representing surfaces and edges. This model has provided key insights into the domain structures observed in magnetic force microscopy (MFM) measurements. Simulation results for single crystal thin-film iron indicate the feasibility of the model for determining magnetic domain wall thickness and mobility in an externally applied field. Because the phase-field model dimensions are limited relative to the size of most specimens used in

  18. Fuzzy logic marketing models for sustainable development

    Directory of Open Access Journals (Sweden)

    Ioan Constantin ENACHE

    2015-06-01

    Full Text Available Fuzzy logic offers a different approach to describe economic and marketing phenomena. By providing a replacement for crisp values the fuzzy sets proved to be efficient alternatives for customer behaviour analysis. These advantages can provide a new way to address sustainable development issues. The present paper aims at presenting the main characteristics of fuzzy models and their main advantages. Evidence on how to implement a fuzzy model and what are its strong points are provided based on previous research and published scientific papers. It is concluded that fuzzy logic gives a different view on a wide range of topics

  19. Alternative Local Development models from the periphery

    Directory of Open Access Journals (Sweden)

    Mauricio Lopez Oropeza

    2013-09-01

    Full Text Available As neoliberal capitalism continues to fail on reducing inequities, and continues to fail on fulfilling its promise of a kind of “development” that would allow impoverished men and women to improve their situation and be able to experience a “freedom” which would empower them with new and better opportunities to vanish their many types of “poverties”, new and alternative models raise, presenting a different and inclusive type of development which intends to respond to their particular situations of exclusion and build on an alternative model.

  20. Ongoing Model Development Analyzing Glass Fracture

    DEFF Research Database (Denmark)

    Molnar, G.; Bojtar, I.; Nielsen, Jens Henrik

    2013-01-01

    Present subject deals with an ongoing experimental and numerical analysis of inplane loaded glass plates. The main goal of the investigation is to develop a hybrid – discrete and finite element – model which could follow the fracture process in annealed and in tempered glass. Measurements...... of the residual stress state before failure and high-speed camera recordings of the failure are being performed in order to verify the numerical model. The primary goal of this research is to follow the overall fracture of a structural element – e.g. beam – loaded inplane. Present paper would like to give...

  1. Model of the Product Development Lifecycle.

    Energy Technology Data Exchange (ETDEWEB)

    He, Sunny L. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Roe, Natalie H. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Wood, Evan [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Nachtigal, Noel M. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Helms, Jovana [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2015-10-01

    While the increased use of Commercial Off-The-Shelf information technology equipment has presented opportunities for improved cost effectiveness and flexibility, the corresponding loss of control over the product's development creates unique vulnerabilities and security concerns. Of particular interest is the possibility of a supply chain attack. A comprehensive model for the lifecycle of hardware and software products is proposed based on a survey of existing literature from academic, government, and industry sources. Seven major lifecycle stages are identified and defined: (1) Requirements, (2) Design, (3) Manufacturing for hardware and Development for software, (4) Testing, (5) Distribution, (6) Use and Maintenance, and (7) Disposal. The model is then applied to examine the risk of attacks at various stages of the lifecycle.

  2. Developing Soil Models for Dynamic Impact Simulations

    Science.gov (United States)

    Fasanella, Edwin L.; Lyle, Karen H.; Jackson, Karen E.

    2009-01-01

    This paper describes fundamental soils characterization work performed at NASA Langley Research Center in support of the Subsonic Rotary Wing (SRW) Aeronautics Program and the Orion Landing System (LS) Advanced Development Program (ADP). LS-DYNA(Registered TradeMark)1 soil impact model development and test-analysis correlation results are presented for: (1) a 38-ft/s vertical drop test of a composite fuselage section, outfitted with four blocks of deployable energy absorbers (DEA), onto sand, and (2) a series of impact tests of a 1/2-scale geometric boilerplate Orion capsule onto soil. In addition, the paper will discuss LS-DYNA contact analysis at the soil/structure interface, methods used to estimate frictional forces, and the sensitivity of the model to density, moisture, and compaction.

  3. Driver Behavior Modeling: Developments and Future Directions

    Directory of Open Access Journals (Sweden)

    Najah AbuAli

    2016-01-01

    Full Text Available The advances in wireless communication schemes, mobile cloud and fog computing, and context-aware services boost a growing interest in the design, development, and deployment of driver behavior models for emerging applications. Despite the progressive advancements in various aspects of driver behavior modeling (DBM, only limited work can be found that reviews the growing body of literature, which only targets a subset of DBM processes. Thus a more general review of the diverse aspects of DBM, with an emphasis on the most recent developments, is needed. In this paper, we provide an overview of advances of in-vehicle and smartphone sensing capabilities and communication and recent applications and services of DBM and emphasize research challenges and key future directions.

  4. DEVELOPING A MODEL OF COOKING GRAIN BATCH

    Directory of Open Access Journals (Sweden)

    E. N. Konstantinov

    2014-01-01

    Full Text Available Summary. By batch cooking of grain accumulated considerable experimental and production material. However, the theory of this process has not been developed to the desired extent. It is shown that the mathematical modeling of the process of cooking the grain batch can be used as a basis for non-stationary diffusion equation and its numerical solution based on the grid method. It is shown that in addition to non-stationary diffusion process by using the grid method can take into account the temperature processes and the theory of swelling of the starch granules. The values of the activation energy of diffusion bound moisture in grains and the pre-exponential value were determined. To describe the swelling of the starch granules used solutions sufficiently numerous studies, and the selected model based on chemical reaction kinetics of the second order. Elaboration of the model of cooking done on experimental data for wheat grits, and concluded the need to address the gap of the starch granules during swelling and separation of layers of material adjacent to the liquid phase during the entire process until the complete cooking of cereal grits. An enlarged under a microscope photos edge dry and tenderized particles showing swelling of the starch granules and the isolation of the outer layer of the particle. Simultaneously taken into account in the model dynamics of temperature changes during heating and mixing the grain of cooking. The simulation results are identified according to a pilot study of cooking barley grits. Found that the developed model accurately describes the results of the pilot study. It is shown that the mathematical model based on the non-stationary diffusion equation, excluding the effects of temperature and swelling of the starch granulestheory gives too high of cooking time.

  5. Agribusiness model approach to territorial food development

    Directory of Open Access Journals (Sweden)

    Murcia Hector Horacio

    2011-04-01

    Full Text Available

    Several research efforts have coordinated the academic program of Agricultural Business Management from the University De La Salle (Bogota D.C., to the design and implementation of a sustainable agribusiness model applied to food development, with territorial projection. Rural development is considered as a process that aims to improve the current capacity and potential of the inhabitant of the sector, which refers not only to production levels and productivity of agricultural items. It takes into account the guidelines of the Organization of the United Nations “Millennium Development Goals” and considered the concept of sustainable food and agriculture development, including food security and nutrition in an integrated interdisciplinary context, with holistic and systemic dimension. Analysis is specified by a model with an emphasis on sustainable agribusiness production chains related to agricultural food items in a specific region. This model was correlated with farm (technical objectives, family (social purposes and community (collective orientations projects. Within this dimension are considered food development concepts and methodologies of Participatory Action Research (PAR. Finally, it addresses the need to link the results to low-income communities, within the concepts of the “new rurality”.

  6. Developing linguistic literacy: a comprehensive model.

    Science.gov (United States)

    Ravid, Dorit; Tolchinsky, Liliana

    2002-05-01

    This is a position paper modelling the domain of linguistic literacy and its development through the life span. It aims to provide a framework for the analysis of language development in the school years, integrating sociolinguistic and psycholinguistic notions of variation, language awareness, and literacy in a comprehensive model. The paper focuses on those aspects of literacy competence that are expressed in language as well as aspects of linguistic knowledge that are affected by literacy competence, tracing the route that children take in appropriating linguistic literacy as part of their cognitive abilities and examining the effect of literacy on language across development. Our view of linguistic literacy consists of one defining feature: control over linguistic variation from both a user-dependent ('lectal') and a context-dependent (modality, genre, and register) perspective; of one concomitant process: metalanguage and its role in language development; and of one condition: familiarity with writing and written language from two aspects: written language as discourse style--the recognition that the kind of language used for writing is essentially different from the one used for speech; and written language as a notational system--the perception and growing command of the representational system that is used in the written modality. Linguistic literacy is viewed as a constituent of language knowledge characterized by the availability of multiple linguistic resources and by the ability to consciously access one's own linguistic knowledge and to view language from various perspectives.

  7. Developing predictive models of health literacy.

    Science.gov (United States)

    Martin, Laurie T; Ruder, Teague; Escarce, José J; Ghosh-Dastidar, Bonnie; Sherman, Daniel; Elliott, Marc; Bird, Chloe E; Fremont, Allen; Gasper, Charles; Culbert, Arthur; Lurie, Nicole

    2009-11-01

    Low health literacy (LHL) remains a formidable barrier to improving health care quality and outcomes. Given the lack of precision of single demographic characteristics to predict health literacy, and the administrative burden and inability of existing health literacy measures to estimate health literacy at a population level, LHL is largely unaddressed in public health and clinical practice. To help overcome these limitations, we developed two models to estimate health literacy. We analyzed data from the 2003 National Assessment of Adult Literacy (NAAL), using linear regression to predict mean health literacy scores and probit regression to predict the probability of an individual having 'above basic' proficiency. Predictors included gender, age, race/ethnicity, educational attainment, poverty status, marital status, language spoken in the home, metropolitan statistical area (MSA) and length of time in U.S. All variables except MSA were statistically significant, with lower educational attainment being the strongest predictor. Our linear regression model and the probit model accounted for about 30% and 21% of the variance in health literacy scores, respectively, nearly twice as much as the variance accounted for by either education or poverty alone. Multivariable models permit a more accurate estimation of health literacy than single predictors. Further, such models can be applied to readily available administrative or census data to produce estimates of average health literacy and identify communities that would benefit most from appropriate, targeted interventions in the clinical setting to address poor quality care and outcomes related to LHL.

  8. Model development for household waste prevention behaviour

    Energy Technology Data Exchange (ETDEWEB)

    Bortoleto, Ana Paula, E-mail: a.bortoleto@sheffield.ac.uk [Department of Urban Engineering, University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-8656 (Japan); Kurisu, Kiyo H.; Hanaki, Keisuke [Department of Urban Engineering, University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-8656 (Japan)

    2012-12-15

    Highlights: Black-Right-Pointing-Pointer We model waste prevention behaviour using structure equation modelling. Black-Right-Pointing-Pointer We merge attitude-behaviour theories with wider models from environmental psychology. Black-Right-Pointing-Pointer Personal norms and perceived behaviour control are the main behaviour predictors. Black-Right-Pointing-Pointer Environmental concern, moral obligation and inconvenience are the main influence on the behaviour. Black-Right-Pointing-Pointer Waste prevention and recycling are different dimensions of waste management behaviour. - Abstract: Understanding waste prevention behaviour (WPB) could enable local governments and decision makers to design more-effective policies for reducing the amount of waste that is generated. By merging well-known attitude-behaviour theories with elements from wider models from environmental psychology, an extensive cognitive framework that provides new and valuable insights is developed for understanding the involvement of individuals in waste prevention. The results confirm the usefulness of the theory of planned behaviour and of Schwartz's altruistic behaviour model as bases for modelling participation in waste prevention. A more elaborate integrated model of prevention was shown to be necessary for the complete analysis of attitudinal aspects associated with waste prevention. A postal survey of 158 respondents provided empirical support for eight of 12 hypotheses. The proposed structural equation indicates that personal norms and perceived behaviour control are the main predictors and that, unlike the case of recycling, subjective norms have a weak influence on WPB. It also suggests that, since social norms have not presented a direct influence, WPB is likely to be influenced by a concern for the environment and the community as well by perceptions of moral obligation and inconvenience. Results also proved that recycling and waste prevention represent different dimensions of waste

  9. High-Fidelity Flash Lidar Model Development

    Science.gov (United States)

    Hines, Glenn D.; Pierrottet, Diego F.; Amzajerdian, Farzin

    2014-01-01

    NASA's Autonomous Landing and Hazard Avoidance Technologies (ALHAT) project is currently developing the critical technologies to safely and precisely navigate and land crew, cargo and robotic spacecraft vehicles on and around planetary bodies. One key element of this project is a high-fidelity Flash Lidar sensor that can generate three-dimensional (3-D) images of the planetary surface. These images are processed with hazard detection and avoidance and hazard relative navigation algorithms, and then are subsequently used by the Guidance, Navigation and Control subsystem to generate an optimal navigation solution. A complex, high-fidelity model of the Flash Lidar was developed in order to evaluate the performance of the sensor and its interaction with the interfacing ALHAT components on vehicles with different configurations and under different flight trajectories. The model contains a parameterized, general approach to Flash Lidar detection and reflects physical attributes such as range and electronic noise sources, and laser pulse temporal and spatial profiles. It also provides the realistic interaction of the laser pulse with terrain features that include varying albedo, boulders, craters slopes and shadows. This paper gives a description of the Flash Lidar model and presents results from the Lidar operating under different scenarios.

  10. Methodological Developments in Geophysical Assimilation Modeling

    Science.gov (United States)

    Christakos, George

    2005-06-01

    This work presents recent methodological developments in geophysical assimilation research. We revisit the meaning of the term "solution" of a mathematical model representing a geophysical system, and we examine its operational formulations. We argue that an assimilation solution based on epistemic cognition (which assumes that the model describes incomplete knowledge about nature and focuses on conceptual mechanisms of scientific thinking) could lead to more realistic representations of the geophysical situation than a conventional ontologic assimilation solution (which assumes that the model describes nature as is and focuses on form manipulations). Conceptually, the two approaches are fundamentally different. Unlike the reasoning structure of conventional assimilation modeling that is based mainly on ad hoc technical schemes, the epistemic cognition approach is based on teleologic criteria and stochastic adaptation principles. In this way some key ideas are introduced that could open new areas of geophysical assimilation to detailed understanding in an integrated manner. A knowledge synthesis framework can provide the rational means for assimilating a variety of knowledge bases (general and site specific) that are relevant to the geophysical system of interest. Epistemic cognition-based assimilation techniques can produce a realistic representation of the geophysical system, provide a rigorous assessment of the uncertainty sources, and generate informative predictions across space-time. The mathematics of epistemic assimilation involves a powerful and versatile spatiotemporal random field theory that imposes no restriction on the shape of the probability distributions or the form of the predictors (non-Gaussian distributions, multiple-point statistics, and nonlinear models are automatically incorporated) and accounts rigorously for the uncertainty features of the geophysical system. In the epistemic cognition context the assimilation concept may be used to

  11. Techniques to develop data for hydrogeochemical models

    Energy Technology Data Exchange (ETDEWEB)

    Thompson, C.M.; Holcombe, L.J.; Gancarz, D.H.; Behl, A.E. (Radian Corp., Austin, TX (USA)); Erickson, J.R.; Star, I.; Waddell, R.K. (Geotrans, Inc., Boulder, CO (USA)); Fruchter, J.S. (Battelle Pacific Northwest Lab., Richland, WA (USA))

    1989-12-01

    The utility industry, through its research and development organization, the Electric Power Research Institute (EPRI), is developing the capability to evaluate potential migration of waste constitutents from utility disposal sites to the environment. These investigations have developed computer programs to predict leaching, transport, attenuation, and fate of inorganic chemicals. To predict solute transport at a site, the computer programs require data concerning the physical and chemical conditions that affect solute transport at the site. This manual provides a comprehensive view of the data requirements for computer programs that predict the fate of dissolved materials in the subsurface environment and describes techniques to measure or estimate these data. In this manual, basic concepts are described first and individual properties and their associated measurement or estimation techniques are described later. The first three sections review hydrologic and geochemical concepts, discuss data requirements for geohydrochemical computer programs, and describe the types of information the programs produce. The remaining sections define and/or describe the properties of interest for geohydrochemical modeling and summarize available technique to measure or estimate values for these properties. A glossary of terms associated with geohydrochemical modeling and an index are provided at the end of this manual. 318 refs., 9 figs., 66 tabs.

  12. GEOINFORMATION MODELLING OF INNOVATION DEVELOPMENT OF AGRICULTURE

    Directory of Open Access Journals (Sweden)

    A. M. Nosonov

    2016-01-01

    Full Text Available Article is devoted to studying of innovation development of agricultural based on the use of GIS-technologies. Implemented design options and developed a specialized GIS database structure « Innovations in the Russian regions». For the analysis of diffusion of innovations in agricultural industry Monte Carlo methods and geoinformation technologies have been used. On the basis of the analysis of diffusion of innovations by means of these methods objective regularities of distribution of the innovations used in agricultural industry in the direction on the one hand from large scientific and technological centers with another – from areas of intensive agriculture on the peripheral territories mainly in east and northern parts of the European Russia, and also Siberia and the Far East are revealed. Use of methods of geoinformation modeling has allowed to conduct researches with creation and the analysis of different degree of complexity of geoinformationcartographic models of territorial systems of the regional level, and the innovative processes which are also happening in them for implementation of management of them and forecasting of development of regional innovation systems.

  13. A stochastic model for early placental development.

    KAUST Repository

    Cotter, Simon L

    2014-08-01

    In the human, placental structure is closely related to placental function and consequent pregnancy outcome. Studies have noted abnormal placental shape in small-for-gestational-age infants which extends to increased lifetime risk of cardiovascular disease. The origins and determinants of placental shape are incompletely understood and are difficult to study in vivo. In this paper, we model the early development of the human placenta, based on the hypothesis that this is driven by a chemoattractant effect emanating from proximal spiral arteries in the decidua. We derive and explore a two-dimensional stochastic model, and investigate the effects of loss of spiral arteries in regions near to the cord insertion on the shape of the placenta. This model demonstrates that disruption of spiral arteries can exert profound effects on placental shape, particularly if this is close to the cord insertion. Thus, placental shape reflects the underlying maternal vascular bed. Abnormal placental shape may reflect an abnormal uterine environment, predisposing to pregnancy complications. Through statistical analysis of model placentas, we are able to characterize the probability that a given placenta grew in a disrupted environment, and even able to distinguish between different disruptions.

  14. Development and application of earth system models

    Science.gov (United States)

    Prinn, Ronald G.

    2013-02-01

    The global environment is a complex and dynamic system. Earth system modeling is needed to help understand changes in interacting subsystems, elucidate the influence of human activities, and explore possible future changes. Integrated assessment of environment and human development is arguably the most difficult and most important "systems" problem faced. To illustrate this approach, we present results from the integrated global system model (IGSM), which consists of coupled submodels addressing economic development, atmospheric chemistry, climate dynamics, and ecosystem processes. An uncertainty analysis implies that without mitigation policies, the global average surface temperature may rise between 3.5 °C and 7.4 °C from 1981-2000 to 2091-2100 (90% confidence limits). Polar temperatures, absent policy, are projected to rise from about 6.4 °C to 14 °C (90% confidence limits). Similar analysis of four increasingly stringent climate mitigation policy cases involving stabilization of greenhouse gases at various levels indicates that the greatest effect of these policies is to lower the probability of extreme changes. The IGSM is also used to elucidate potential unintended environmental consequences of renewable energy at large scales. There are significant reasons for attention to climate adaptation in addition to climate mitigation that earth system models can help inform. These models can also be applied to evaluate whether "climate engineering" is a viable option or a dangerous diversion. We must prepare young people to address this issue: The problem of preserving a habitable planet will engage present and future generations. Scientists must improve communication if research is to inform the public and policy makers better.

  15. Space market model development project, phase 3

    Science.gov (United States)

    Bishop, Peter C.; Hamel, Gary P.

    1989-01-01

    The results of a research project investigating information needs for space commercialization is described. The Space Market Model Development Project (SMMDP) was designed to help NASA identify the information needs of the business community and to explore means to meet those needs. The activity of the SMMDP is reviewed and a report of its operation via three sections is presented. The first part contains a brief historical review of the project since inception. The next part reports results of Phase 3, the most recent stage of activity. Finally, overall conclusions and observations based on the SMMDP research results are presented.

  16. Development of Mouse Lung Deposition Models

    Science.gov (United States)

    2015-07-01

    deposition calculations in each strain of mouse: first by 3/1)TLC/FRC( , where FRC is the functional residual capacity or lung volume at rest and TLC is the...total lung capacity , to adjust airway dimensions to rest conditions, and second by 3/1T )2/V1( + , where TV is the tidal volume , to account for...geometry that was previously developed for humans, rats, and rhesus monkeys [6], [7]. Inputs to the model included lung geometry and volumes , and

  17. Development model of the fine dining restaurant

    OpenAIRE

    Miško Radjenović

    2014-01-01

    Purpose –The purpose of this work is to support the hypothesis that the Fine dining restaurants are important part of hotel offer. Design –In the first and second part of this work the special focus is given on the history and positive and negative aspects offline dining restaurant business. In the third and fourth part, this paper will present the model for fine dining development by analyzing practical examples and steps needed to be taken for opening this type of restaurant. Methodology –H...

  18. Business model in research-development activity

    Directory of Open Access Journals (Sweden)

    Koszałka Jerzy

    2016-09-01

    Full Text Available The partners and allies of business practice in the processes of modernization of the economy are scientific-research institutions, such as scientific institutes, research-development units and universities. A market on which companies can look for the solutions they need and scientific-research institutions can look for inspiration, partners and capital is being formed. The market provides conditions for operation, development and implementation of developed solutions. Taking into consideration the complexity of market, technical, legal, financial, or intellectual property protection issues, research-development units are more and more frequently unable to function efficiently without a clear and unequivocal definition of goals, methods and conditions of activity. Their market offer has to take into consideration not just scientific-research, or methodological aspects. Taking into consideration continuously growing demands of the clients and pressure of the competition, scientific-research institutions have to pay attention also to market, information, personnel, or financial aspects typical of strictly commercial ventures. What may support a comprehensive preparation and implementation of scientific-research activities under market conditions are tools successfully used in trade and economy, such as business models. These issues are the basis of deliberations contained in this work.

  19. Model continuity in discrete event simulation: A framework for model-driven development of simulation models

    NARCIS (Netherlands)

    Cetinkaya, D; Verbraeck, A.; Seck, MD

    2015-01-01

    Most of the well-known modeling and simulation (M&S) methodologies state the importance of conceptual modeling in simulation studies, and they suggest the use of conceptual models during the simulation model development process. However, only a limited number of methodologies refers to how to

  20. Argonne Bubble Experiment Thermal Model Development II

    Energy Technology Data Exchange (ETDEWEB)

    Buechler, Cynthia Eileen [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-07-01

    This report describes the continuation of the work reported in “Argonne Bubble Experiment Thermal Model Development”. The experiment was performed at Argonne National Laboratory (ANL) in 2014. A rastered 35 MeV electron beam deposited power in a solution of uranyl sulfate, generating heat and radiolytic gas bubbles. Irradiations were performed at three beam power levels, 6, 12 and 15 kW. Solution temperatures were measured by thermocouples, and gas bubble behavior was observed. This report will describe the Computational Fluid Dynamics (CFD) model that was developed to calculate the temperatures and gas volume fractions in the solution vessel during the irradiations. The previous report described an initial analysis performed on a geometry that had not been updated to reflect the as-built solution vessel. Here, the as-built geometry is used. Monte-Carlo N-Particle (MCNP) calculations were performed on the updated geometry, and these results were used to define the power deposition profile for the CFD analyses, which were performed using Fluent, Ver. 16.2. CFD analyses were performed for the 12 and 15 kW irradiations, and further improvements to the model were incorporated, including the consideration of power deposition in nearby vessel components, gas mixture composition, and bubble size distribution. The temperature results of the CFD calculations are compared to experimental measurements.

  1. Development of a leadership competency model.

    Science.gov (United States)

    Sherman, Rose O; Bishop, Mary; Eggenberger, Terry; Karden, Ruth

    2007-02-01

    Although research findings support that the nurse manager has a pivotal role in influencing all aspects of the nursing environment, recruiting talented staff into these nursing leadership positions has become increasingly more difficult. There is a need to better understand the competencies needed by contemporary nurse managers and the challenges in the role. The purpose of this research was to explore the viewpoints of 120 nurse manager study participants on the contemporary nurse manager role and to gain perspective on the critical leadership skills and competencies to build a nursing leadership competency model. A grounded theory methodology was used in this study to capture the perspectives of the nurse managers interviewed about their role. Six competency categories emerged from the research findings to form a nursing leadership competency model. Two major themes identified from the data included the nurse manager role as a career choice and the stressors and challenges in the role. The results of this study led to the design of a nursing leadership competency model and confirmed that there is a need to formally develop and mentor our next generation of nurse leaders.

  2. Building Energy Model Development for Retrofit Homes

    Energy Technology Data Exchange (ETDEWEB)

    Chasar, David; McIlvaine, Janet; Blanchard, Jeremy; Widder, Sarah H.; Baechler, Michael C.

    2012-09-30

    Based on previous research conducted by Pacific Northwest National Laboratory and Florida Solar Energy Center providing technical assistance to implement 22 deep energy retrofits across the nation, 6 homes were selected in Florida and Texas for detailed post-retrofit energy modeling to assess realized energy savings (Chandra et al, 2012). However, assessing realized savings can be difficult for some homes where pre-retrofit occupancy and energy performance are unknown. Initially, savings had been estimated using a HERS Index comparison for these homes. However, this does not account for confounding factors such as occupancy and weather. This research addresses a method to more reliably assess energy savings achieved in deep energy retrofits for which pre-retrofit utility bills or occupancy information in not available. A metered home, Riverdale, was selected as a test case for development of a modeling procedure to account occupancy and weather factors, potentially creating more accurate estimates of energy savings. This “true up” procedure was developed using Energy Gauge USA software and post-retrofit homeowner information and utility bills. The 12 step process adjusts the post-retrofit modeling results to correlate with post-retrofit utility bills and known occupancy information. The “trued” post retrofit model is then used to estimate pre-retrofit energy consumption by changing the building efficiency characteristics to reflect the pre-retrofit condition, but keeping all weather and occupancy-related factors the same. This creates a pre-retrofit model that is more comparable to the post-retrofit energy use profile and can improve energy savings estimates. For this test case, a home for which pre- and post- retrofit utility bills were available was selected for comparison and assessment of the accuracy of the “true up” procedure. Based on the current method, this procedure is quite time intensive. However, streamlined processing spreadsheets or

  3. Developing and Extending a Cyberinfrastructure Model

    Energy Technology Data Exchange (ETDEWEB)

    Alvarez, Rosio

    2007-11-13

    Increasingly, research and education institutions are realizing the strategic value and challenge of deploying and supporting institutional cyberinfrastructure (CI). Cyberinfrastructure is composed of high performance computing systems, massive storage systems, visualization systems, and advanced networks to interconnect the components within and across institutions and research communities. CI also includes the professionals with expertise in scientific application and algorithm development and parallel systems operation. Unlike ?regular? IT infrastructure, the manner in which the components are configured and skills to do so are highly specific and specialized. Planning and coordinating these assets is a fundamental step toward enhancing an institution?s research competitiveness and return on personnel, technology, and facilities investments. Coordinated deployment of CI assets has implications across the institution. Consider the VC for Research whose new faculty in the Life Sciences are now asking for simulation systems rather than wet labs, or the Provost who lost another faculty candidate to a peer institution that offered computational support for research, or the VC for Administration who has seen a spike in power and cooling demands from many of the labs and office spaces being converted to house systems. These are just some of the issues that research institutions are wrestling with as research becomes increasingly computational, data-intensive and interdisciplinary. This bulletin will discuss these issues and will present an approach for developing a cyberinfrastructure model that was successfully developed at one institution and then deployed across institutions.

  4. The Bioeconomy Model in Future Sustainable Development

    Directory of Open Access Journals (Sweden)

    Ipate Nicolae

    2015-07-01

    Full Text Available The future of sustainable development is the bioeconomy with the ―global‖ solution; both global and local action for developed the renewable energy generation. When local solutions are implemented is being laid for global solutions are positive affect the national economy. The implementation of the bioeconomy strategy used by society to prevent urgent problems, such as increasing competition for natural resources, climate change, rural sustainable development. The bioeconomy is a new economic and social order and promotes systemic change from using non-renewable resources to renewables. Bioeconomy reveals that production, which involves the transformation of a limited stock of matter and energy, but respecting the same laws that govern entropy closed systems, the entropy or unavailable matter and energy in the forms tend to increase continuously. Economic growth not only increases the apparent output per unit of inputs, which is performed using finite stock of matter and energy in the world. The current economy is based on fossil fuels and other material inputs suffering entropic degradation, both in the raw material extraction and pollution. The production, even if technical progress leads to lower overall yields. The idea of a steady state as the final economic growth that perpetuated indefinitely pendulum model is an impossibility

  5. Documentation of the petroleum market model (PMM). Appendix: Model developer`s report

    Energy Technology Data Exchange (ETDEWEB)

    1994-12-28

    The Office of Integrated Analysis and Forecasting (OIAF) is required to provide complete model documentation to meet the EIA Model Acceptance Standards. The EIA Model Documentation: Petroleum Market Model of the National Energy Modeling System provides a complete description of the Petroleum Market Model`s (PMM) methodology, and relation to other modules in the National Energy Modeling System (NEMS). This Model Developer`s Report (MDR) serves as an appendix to the methodology documentation and provides an assessment of the sensitivity of PMM results to changes in input data. The MDR analysis for PMM is performed by varying several sets of input variables one-at-a-time and examining the effect on a set of selected output variables. The analysis is based on stand-alone, rather than integrated, National Energy Modeling System (NEMS) runs. This means that other NEMS modules are not responding to PMM outputs. The PMM models petroleum refining and marketing. The purpose of the PMM is to project petroleum product prices, refining activities, and movements of petroleum into the United States and among domestic regions. In addition, the PMM estimates capacity expansion and fuel consumption in, the refining industry. The PMM is also used to analyze a wide variety of petroleum-related issues and policies, in order to foster better understanding of the petroleum refining and marketing industry and the effects of certain policies and regulations. The PMM simulates the operation of petroleum refineries in the United States, including the supply and transportation of crude oil to refineries, the regional processing of these raw materials into petroleum products, and the distribution of petroleum products to meet regional demands. The essential outputs of this model are product prices, a petroleum supply/demand balance, demands for refinery fuel use, and capacity expansion.

  6. A stochastic model for retinocollicular map development

    Directory of Open Access Journals (Sweden)

    Tsigankov Dmitry N

    2004-08-01

    Full Text Available Abstract Background We examine results of gain-of-function experiments on retinocollicular maps in knock-in mice [Brown et al. (2000 Cell 102:77]. In wild-type mice the temporal-nasal axis of retina is mapped to the rostral-caudal axis of superior colliculus. The established map is single-valued, which implies that each point in retina maps to a unique termination zone in superior colliculus. In homozygous Isl2/EphA3 knock-in mice the map is double-valued, which means that each point on retina maps to two termination zones in superior colliculus. This is because about 50 percent of cells in retina express Isl2, and two types of projections, wild-type and Isl2/EphA3 positive, form two branches of the map. In heterozygous Isl2/EphA3 knock-ins the map is intermediate between the homozygous and wild-type: it is single-valued in temporal and double-valued in the nasal parts of retina. In this study we address possible reasons for such a bifurcation of the map. Results We study the map formation using stochastic model based on Markov chains. In our model the map undergoes a series of reconstructions with probabilities dependent upon a set of chemical cues. Our model suggests that the map in heterozygotes is single-valued in temporal region of retina for two reasons. First, the inhomogeneous gradient of endogenous receptor in retina makes the impact of exogenous receptor less significant in temporal retina. Second, the gradient of ephrin in the corresponding region of superior colliculus is smaller, which reduces the chemical signal-to-noise ratio. We predict that if gradient of ephrin is reduced by a genetic manipulation, the single-valued region of the map should extend to a larger portion of temporal retina, i.e. the point of transition between single-and doulble-valued maps should move to a more nasal position in Isl2-EphA3 heterozygotes. Conclusions We present a theoretical model for retinocollicular map development, which can account for

  7. ER@CEBAF: Modeling code developments

    Energy Technology Data Exchange (ETDEWEB)

    Meot, F. [Brookhaven National Lab. (BNL), Upton, NY (United States); Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States); Roblin, Y. [Brookhaven National Lab. (BNL), Upton, NY (United States); Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States)

    2016-04-13

    A proposal for a multiple-pass, high-energy, energy-recovery experiment using CEBAF is under preparation in the frame of a JLab-BNL collaboration. In view of beam dynamics investigations regarding this project, in addition to the existing model in use in Elegant a version of CEBAF is developed in the stepwise ray-tracing code Zgoubi, Beyond the ER experiment, it is also planned to use the latter for the study of polarization transport in the presence of synchrotron radiation, down to Hall D line where a 12 GeV polarized beam can be delivered. This Note briefly reports on the preliminary steps, and preliminary outcomes, based on an Elegant to Zgoubi translation.

  8. Developing a Forensic Continuous Audit Model

    Directory of Open Access Journals (Sweden)

    Grover S. Kearns

    2011-06-01

    Full Text Available Despite increased attention to internal controls and risk assessment, traditional audit approaches do not seem to be highly effective in uncovering the majority of frauds. Less than 20 percent of all occupational frauds are uncovered by auditors. Forensic accounting has recognized the need for automated approaches to fraud analysis yet research has not examined the benefits of forensic continuous auditing as a method to detect and deter corporate fraud. The purpose of this paper is to show how such an approach is possible. A model is presented that supports the acceptance of forensic continuous auditing by auditors and management as an effective tool to support the audit function, meet management’s regulatory objectives, and to combat fraud. An approach to developing such a system is presented.

  9. Argonne Bubble Experiment Thermal Model Development III

    Energy Technology Data Exchange (ETDEWEB)

    Buechler, Cynthia Eileen [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2018-01-11

    This report describes the continuation of the work reported in “Argonne Bubble Experiment Thermal Model Development” and “Argonne Bubble Experiment Thermal Model Development II”. The experiment was performed at Argonne National Laboratory (ANL) in 2014. A rastered 35 MeV electron beam deposited power in a solution of uranyl sulfate, generating heat and radiolytic gas bubbles. Irradiations were performed at beam power levels between 6 and 15 kW. Solution temperatures were measured by thermocouples, and gas bubble behavior was recorded. The previous report2 described the Monte-Carlo N-Particle (MCNP) calculations and Computational Fluid Dynamics (CFD) analysis performed on the as-built solution vessel geometry. The CFD simulations in the current analysis were performed using Ansys Fluent, Ver. 17.2. The same power profiles determined from MCNP calculations in earlier work were used for the 12 and 15 kW simulations. The primary goal of the current work is to calculate the temperature profiles for the 12 and 15 kW cases using reasonable estimates for the gas generation rate, based on images of the bubbles recorded during the irradiations. Temperature profiles resulting from the CFD calculations are compared to experimental measurements.

  10. Development of a Model Foamy Viscous Fluid

    Directory of Open Access Journals (Sweden)

    Vial C.

    2013-08-01

    Full Text Available The objective is to develop a model viscous foamy fluid, i.e. below the very wet limit, the rheological and stability properties of which can be tuned. First, the method used for the preparation of foamy fluids is detailed, including process and formulation. Then, experimental results highlight that stable foamy fluids with a monomodal bubble size distribution can be prepared with a void fraction between 25% and 50% (v/v. Their viscoelastic properties under flow and low-strain oscillatory conditions are shown to result from the interplay between the formulation of the continuous phase, void fraction and bubble size. Their apparent viscosity can be described using the Cross equation and zero-shear Newtonian viscosity may be predicted by a Mooney equation up to a void fraction about 40%. The Cox-Merz and the Laun’s rules apply when the capillary number Ca is lower than 0.1. The upper limit of the zero-shear plateau region decreases when void fraction increases or bubble size decreases. In the shear-thinning region, shear stress varies with Ca1/2, as in wet foams with immobile surfaces. Finally, foamy fluids can be sheared up to Ca about 0.1 without impairing their microstructure. Their stability at rest achieves several hours and increases with void fraction due to compact packing constraints. These constitute, therefore, versatile model fluids to investigate the behaviour of foamy fluids below the very wet limit in process conditions.

  11. Rolling Resistance Measurement and Model Development

    DEFF Research Database (Denmark)

    Andersen, Lasse Grinderslev; Larsen, Jesper; Fraser, Elsje Sophia

    2015-01-01

    There is an increased focus worldwide on understanding and modeling rolling resistance because reducing the rolling resistance by just a few percent will lead to substantial energy savings. This paper reviews the state of the art of rolling resistance research, focusing on measuring techniques......, surface and texture modeling, contact models, tire models, and macro-modeling of rolling resistance...

  12. Model Driven Development of Simulation Models : Defining and Transforming Conceptual Models into Simulation Models by Using Metamodels and Model Transformations

    NARCIS (Netherlands)

    Küçükkeçeci Çetinkaya, D.

    2013-01-01

    Modeling and simulation (M&S) is an effective method for analyzing and designing systems and it is of interest to scientists and engineers from all disciplines. This thesis proposes the application of a model driven software development approach throughout the whole set of M&S activities and it

  13. The development of a model for dealing with secondary traumatic ...

    African Journals Online (AJOL)

    The development of a model for dealing with secondary traumatic stress in mental health workers in Rwanda. ... Aim: To develop a comprehensive model to manage the effects of STS in mental health workers operating in Rwanda. Method: An action research project was initiated to develop this model and data for the model ...

  14. An Integrated Professional Development Model for Effective Teaching

    Science.gov (United States)

    Kuijpers, J. M.; Houtveen, A. A. M.; Wubbels, Th.

    2010-01-01

    This article examines the design of a professional development model that aims to improve student achievement. This model has been designed by combining and supplementing elements from school-improvement literature and existing professional development models. Existing models from two largely independent approaches to professional development of…

  15. Adolescent Psychosocial Development: A Review of Longitudinal Models and Research

    Science.gov (United States)

    Meeus, Wim

    2016-01-01

    This review used 4 types of longitudinal models (descriptive models, prediction models, developmental sequence models and longitudinal mediation models) to identify regular patterns of psychosocial development in adolescence. Eight patterns of adolescent development were observed across countries: (1) adolescent maturation in multiple…

  16. Teachers' Development Model to Authentic Assessment by Empowerment Evaluation Approach

    Science.gov (United States)

    Charoenchai, Charin; Phuseeorn, Songsak; Phengsawat, Waro

    2015-01-01

    The purposes of this study were 1) Study teachers authentic assessment, teachers comprehension of authentic assessment and teachers needs for authentic assessment development. 2) To create teachers development model. 3) Experiment of teachers development model. 4) Evaluate effectiveness of teachers development model. The research is divided into 4…

  17. Developing Fast and Reliable Flood Models

    DEFF Research Database (Denmark)

    Thrysøe, Cecilie; Toke, Jens; Borup, Morten

    2016-01-01

    is modelled by response surface surrogates, which are empirical data driven models. These are trained using the volume-discharge relations by piecewise linear functions. (ii) The surface flooding is modelled by lower-fidelity physically based surrogates, which are based on surface depressions and flow paths...... accuracy. The model shows no instability, hence larger time steps can be applied, which reduces the computational time by more than a factor 1400. In conclusion, surrogate models show great potential for usage in urban water modelling....

  18. Developments in vapour cloud explosion blast modeling

    NARCIS (Netherlands)

    Mercx, W.P.M.; Berg, A.C. van den; Hayhurst, C.J.; Robertson, N.J.; Moran, K.C.

    2000-01-01

    TNT Equivalency methods are widely used for vapour cloud explosion blast modeling. Presently, however, other types of models are available which do not have the fundamental objections TNT Equivalency models have. TNO Multi-Energy method is increasingly accepted as a more reasonable alternative to be

  19. Architecture design in global and model-centric software development

    NARCIS (Netherlands)

    Heijstek, Werner

    2012-01-01

    This doctoral dissertation describes a series of empirical investigations into representation, dissemination and coordination of software architecture design in the context of global software development. A particular focus is placed on model-centric and model-driven software development.

  20. Applying mechanistic models in bioprocess development

    DEFF Research Database (Denmark)

    Lencastre Fernandes, Rita; Bodla, Vijaya Krishna; Carlquist, Magnus

    2013-01-01

    incorporates process-relevant input (critical process variables)-output (product concentration and product quality attributes) relations. The model therefore has great value in planning experiments, or in determining which critical process variables need to be monitored and controlled tightly. Mechanistic......The available knowledge on the mechanisms of a bioprocess system is central to process analytical technology. In this respect, mechanistic modeling has gained renewed attention, since a mechanistic model can provide an excellent summary of available process knowledge. Such a model therefore...... models should be combined with proper model analysis tools, such as uncertainty and sensitivity analysis. When assuming distributed inputs, the resulting uncertainty in the model outputs can be decomposed using sensitivity analysis to determine which input parameters are responsible for the major part...

  1. Hypersonic Vehicle Propulsion System Simplified Model Development

    Science.gov (United States)

    Stueber, Thomas J.; Raitano, Paul; Le, Dzu K.; Ouzts, Peter

    2007-01-01

    This document addresses the modeling task plan for the hypersonic GN&C GRC team members. The overall propulsion system modeling task plan is a multi-step process and the task plan identified in this document addresses the first steps (short term modeling goals). The procedures and tools produced from this effort will be useful for creating simplified dynamic models applicable to a hypersonic vehicle propulsion system. The document continues with the GRC short term modeling goal. Next, a general description of the desired simplified model is presented along with simulations that are available to varying degrees. The simulations may be available in electronic form (FORTRAN, CFD, MatLab,...) or in paper form in published documents. Finally, roadmaps outlining possible avenues towards realizing simplified model are presented.

  2. Dynamic models of development and the mechanistic-organismic controversy

    NARCIS (Netherlands)

    Molenaar, P.C.M.; Oppenheimer, L.J.T.

    1985-01-01

    Presents a sequence of dynamic models with increasing structural complexity starting with a prototypical model of Newtonian mechanics. The implicated smooth variation along a dimension of structural complexity yields dynamic models that display organismic properties such as stagewise development and

  3. Development of a generic activities model of command and control

    OpenAIRE

    Stanton, NA; Baber, C; Walker, GH; Houghton, RJ; McMaster, R; Stewart, R.; D.; Harris; Jenkins, DP; Young, MS; Salmon, PM

    2008-01-01

    This paper reports on five different models of command and control. Four different models are reviewed: a process model, a contextual control model, a decision ladder model and a functional model. Further to this, command and control activities are analysed in three distinct domains: armed forces, emergency services and civilian services. From this analysis, taxonomies of command and control activities are developed that give rise to an activities model of command and control. This model w...

  4. International orientation on methodologies for modelling developments in road safety.

    NARCIS (Netherlands)

    Reurings, M.C.B. & Commandeur, J.J.F.

    2007-01-01

    This report gives an overview of the models developed in countries other than the Netherlands to evaluate past developments in road traffic safety and to obtain estimates of these developments in the future. These models include classical linear regression and loglinear models as applied in Great

  5. A Neuroconstructivist Model of Past Tense Development and Processing

    Science.gov (United States)

    Westermann, Gert; Ruh, Nicolas

    2012-01-01

    We present a neural network model of learning and processing the English past tense that is based on the notion that experience-dependent cortical development is a core aspect of cognitive development. During learning the model adds and removes units and connections to develop a task-specific final architecture. The model provides an integrated…

  6. Aqueous Solution Vessel Thermal Model Development II

    Energy Technology Data Exchange (ETDEWEB)

    Buechler, Cynthia Eileen [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-10-28

    The work presented in this report is a continuation of the work described in the May 2015 report, “Aqueous Solution Vessel Thermal Model Development”. This computational fluid dynamics (CFD) model aims to predict the temperature and bubble volume fraction in an aqueous solution of uranium. These values affect the reactivity of the fissile solution, so it is important to be able to calculate them and determine their effects on the reaction. Part A of this report describes some of the parameter comparisons performed on the CFD model using Fluent. Part B describes the coupling of the Fluent model with a Monte-Carlo N-Particle (MCNP) neutron transport model. The fuel tank geometry is the same as it was in the May 2015 report, annular with a thickness-to-height ratio of 0.16. An accelerator-driven neutron source provides the excitation for the reaction, and internal and external water cooling channels remove the heat. The model used in this work incorporates the Eulerian multiphase model with lift, wall lubrication, turbulent dispersion and turbulence interaction. The buoyancy-driven flow is modeled using the Boussinesq approximation, and the flow turbulence is determined using the k-ω Shear-Stress-Transport (SST) model. The dispersed turbulence multiphase model is employed to capture the multiphase turbulence effects.

  7. Animal Migraine Models for Drug Development

    DEFF Research Database (Denmark)

    Jansen-Olesen, Inger; Tfelt-Hansen, Peer; Olesen, Jes

    2013-01-01

    for headache has almost come to a standstill partly because of a lack of valid animal models. Here we review previous models with emphasis on optimal characteristics of a future model. In addition to selection of animal species, the method of induction of migraine-like changes and the method of recording...... responses are likely to be behavioral, allowing multiple experiments in each individual animal. Distinction is made between acute and prophylactic models and how to validate each of them. Modern insight into neurobiological mechanisms of migraine is so good that it is only a question of resources...

  8. A Development Model for Foreign Police

    Science.gov (United States)

    2014-06-13

    Organizational Development ........................................................................................ 62...must be balanced with organizational development to ensure that the receiving nation can sustain the additional equipment and skill sets. Next, the...the UN did not initially focus on organizational development of the Kosovo Police Service (KPS), it did begin a program to build

  9. On Support Functions for the Development of MFM Models

    DEFF Research Database (Denmark)

    Heussen, Kai; Lind, Morten

    2012-01-01

    a review of MFM applications, and contextualizes the model development with respect to process design and operation knowledge. Developing a perspective for an environment for MFM-oriented model- and application-development a tool-chain is outlined and relevant software functions are discussed....... With a perspective on MFM-modeling for existing processes and automation design, modeling stages and corresponding formal model properties are identified. Finally, practically feasible support functions and model-checks to support the model-development are suggested.......A modeling environment and methodology are necessary to ensure quality and reusability of models in any domain. For MFM in particular, as a tool for modeling complex systems, awareness has been increasing for this need. Introducing the context of modeling support functions, this paper provides...

  10. Cytoview: Development of a cell modelling framework

    Indian Academy of Sciences (India)

    2007-07-06

    Jul 6, 2007 ... The different issues that have been addressed are ontologies, feature description and model building. The framework describes dotted representations and tree data structures to integrate diverse pieces of data and parametric models enabling size, shape and location descriptions. The framework serves ...

  11. Some recent developments in stochastic volatility modelling

    DEFF Research Database (Denmark)

    Barndorff-Nielsen, Ole Eiler; Nicolato, Elisa; Shephard, N.

    2002-01-01

    This paper reviews and puts in context some of our recent work on stochastic volatility (SV) modelling for financial economics. Here our main focus is on: (i) the relationship between subordination and SV, (ii) OU based volatility models, (iii) exact option pricing, (iv) realized power variation ...

  12. Manpower Planning Model for Less Developed Countries ...

    African Journals Online (AJOL)

    The need for manpower planning in underdeveloped countries is necessary to remove widespread unemployment and disguised unemployment in such economies. Models for predicting future manpower requirements are indispensable tools for planners and policy makers. A model which captures manpower demand and ...

  13. Asteroid thermal modeling: recent developments and applications

    NARCIS (Netherlands)

    Harris, A. W.; Mueller, M.

    2006-01-01

    A variety of thermal models are used for the derivation of asteroid physical parameters from thermal-infrared observations Simple models based on spherical geometry are often adequate for obtaining sizes and albedos when very little information about an object is available However sophisticated

  14. Development of the Integrated Communication Model

    Science.gov (United States)

    Ho, Hua-Kuo

    2008-01-01

    Human communication is a critical issue in personal life. It also should be the indispensable core element of general education curriculum in universities and colleges. Based on literature analysis and the author's clinical observation, the importance of human communication, functions of model, and often seen human communication models were…

  15. Applying a Model-Based Approach for Embedded System Development

    NARCIS (Netherlands)

    Bunse, C.; Gross, H.G.; Peper, C.

    2007-01-01

    Model-based and component-oriented software development approaches are slowly superseding traditional ways of developing embedded systems. For investigating to which extent model-based development is feasible for embedded system development, we conducted a case study in which a small embedded system

  16. Place-Based Investment Model of Talent Development: A Proposed Model for Developing and Reinvesting Talents within the Community

    Science.gov (United States)

    Paul, Kristina Ayers; Seward, Kristen K.

    2016-01-01

    The place-based investment model (PBIM) of talent development is a programming model for developing talents of high-potential youth in ways that could serve as an investment in the community. In this article, we discuss the PBIM within rural contexts. The model is grounded in three theories--Moon's personal talent development theory, Sternberg's…

  17. Challenges in the transition to model-based development.

    Science.gov (United States)

    Grasela, Thaddeus H; Fiedler-Kelly, Jill; Walawander, Cynthia A; Owen, Joel S; Cirincione, Brenda B; Reitz, Kathleen E; Ludwig, Elizabeth A; Passarell, Julie A; Dement, Charles W

    2005-10-05

    Practitioners of the art and science of pharmacometrics are well aware of the considerable effort required to successfully complete modeling and simulation activities for drug development programs. This is particularly true because of the current, ad hoc implementation wherein modeling and simulation activities are piggybacked onto traditional development programs. This effort, coupled with the failure to explicitly design development programs around modeling and simulation, will continue to be an important obstacle to the successful transition to model-based drug development. Challenges with timely data availability, high data discard rates, delays in completing modeling and simulation activities, and resistance of development teams to the use of modeling and simulation in decision making are all symptoms of an immature process capability for performing modeling and simulation. A process that will fulfill the promise of model-based development will require the development and deployment of three critical elements. The first is the infrastructure--the data definitions and assembly processes that will allow efficient pooling of data across trials and development programs. The second is the process itself--developing guidelines for deciding when and where modeling and simulation should be applied and the criteria for assessing performance and impact. The third element concerns the organization and culture--the establishment of truly integrated, multidisciplinary, and multiorganizational development teams trained in the use of modeling and simulation in decision-making. Creating these capabilities, infrastructure, and incentivizations are critical to realizing the full value of modeling and simulation in drug development.

  18. Anaerobic digestion model no. 1-based distributed parameter model of an anaerobic reactor: I. Model development.

    Science.gov (United States)

    Mu, S J; Zeng, Y; Wu, P; Lou, S J; Tartakovsky, B

    2008-06-01

    This work presents a distributed parameter model of the anaerobic digestion process. The model is based on the Anaerobic digestion model no. 1 (ADM1) and was developed to simulate anaerobic digestion process in high-rate reactors with significant axial dispersion, such as in upflow anaerobic sludge bed (UASB) reactors. The model, which was named ADM1d, combines ADM1's kinetics of biomass growth and substrate transformation with axial dispersion material balances. ADM1d uses a hyperbolic tangent function to describe biomass distribution within a one compartment model. A comparison of this approach with a two-compartment, sludge bed - liquid above the bed, model showed similar simulation results while the one-compartment model had less equations. A comparison of orthogonal collocation and finite difference algorithms for numerical solution of ADM1d showed better stability of the finite difference algorithm.

  19. Test Driven Development of Scientific Models

    Science.gov (United States)

    Clune, Thomas L.

    2014-01-01

    Test-Driven Development (TDD), a software development process that promises many advantages for developer productivity and software reliability, has become widely accepted among professional software engineers. As the name suggests, TDD practitioners alternate between writing short automated tests and producing code that passes those tests. Although this overly simplified description will undoubtedly sound prohibitively burdensome to many uninitiated developers, the advent of powerful unit-testing frameworks greatly reduces the effort required to produce and routinely execute suites of tests. By testimony, many developers find TDD to be addicting after only a few days of exposure, and find it unthinkable to return to previous practices.After a brief overview of the TDD process and my experience in applying the methodology for development activities at Goddard, I will delve more deeply into some of the challenges that are posed by numerical and scientific software as well as tools and implementation approaches that should address those challenges.

  20. Developments in multidimensional spatial data models

    CERN Document Server

    Abdul Rahman, Alias; Gold, Christopher; Said, Mohamad Nor

    2014-01-01

    This book presents the latest research developments in geoinformation science, including such sub-disciplines as geomatic engineering, GIS, remote sensing, digital photogrammetry, digital cartography and more.

  1. Clinical Predictive Modeling Development and Deployment through FHIR Web Services

    Science.gov (United States)

    Khalilia, Mohammed; Choi, Myung; Henderson, Amelia; Iyengar, Sneha; Braunstein, Mark; Sun, Jimeng

    2015-01-01

    Clinical predictive modeling involves two challenging tasks: model development and model deployment. In this paper we demonstrate a software architecture for developing and deploying clinical predictive models using web services via the Health Level 7 (HL7) Fast Healthcare Interoperability Resources (FHIR) standard. The services enable model development using electronic health records (EHRs) stored in OMOP CDM databases and model deployment for scoring individual patients through FHIR resources. The MIMIC2 ICU dataset and a synthetic outpatient dataset were transformed into OMOP CDM databases for predictive model development. The resulting predictive models are deployed as FHIR resources, which receive requests of patient information, perform prediction against the deployed predictive model and respond with prediction scores. To assess the practicality of this approach we evaluated the response and prediction time of the FHIR modeling web services. We found the system to be reasonably fast with one second total response time per patient prediction. PMID:26958207

  2. Clinical Predictive Modeling Development and Deployment through FHIR Web Services.

    Science.gov (United States)

    Khalilia, Mohammed; Choi, Myung; Henderson, Amelia; Iyengar, Sneha; Braunstein, Mark; Sun, Jimeng

    2015-01-01

    Clinical predictive modeling involves two challenging tasks: model development and model deployment. In this paper we demonstrate a software architecture for developing and deploying clinical predictive models using web services via the Health Level 7 (HL7) Fast Healthcare Interoperability Resources (FHIR) standard. The services enable model development using electronic health records (EHRs) stored in OMOP CDM databases and model deployment for scoring individual patients through FHIR resources. The MIMIC2 ICU dataset and a synthetic outpatient dataset were transformed into OMOP CDM databases for predictive model development. The resulting predictive models are deployed as FHIR resources, which receive requests of patient information, perform prediction against the deployed predictive model and respond with prediction scores. To assess the practicality of this approach we evaluated the response and prediction time of the FHIR modeling web services. We found the system to be reasonably fast with one second total response time per patient prediction.

  3. Developing Physician Migration Estimates for Workforce Models.

    Science.gov (United States)

    Holmes, George M; Fraher, Erin P

    2017-02-01

    To understand factors affecting specialty heterogeneity in physician migration. Physicians in the 2009 American Medical Association Masterfile data were matched to those in the 2013 file. Office locations were geocoded in both years to one of 293 areas of the country. Estimated utilization, calculated for each specialty, was used as the primary predictor of migration. Physician characteristics (e.g., specialty, age, sex) were obtained from the 2009 file. Area characteristics and other factors influencing physician migration (e.g., rurality, presence of teaching hospital) were obtained from various sources. We modeled physician location decisions as a two-part process: First, the physician decides whether to move. Second, conditional on moving, a conditional logit model estimates the probability a physician moved to a particular area. Separate models were estimated by specialty and whether the physician was a resident. Results differed between specialties and according to whether the physician was a resident in 2009, indicating heterogeneity in responsiveness to policies. Physician migration was higher between geographically proximate states with higher utilization for that specialty. Models can be used to estimate specialty-specific migration patterns for more accurate workforce modeling, including simulations to model the effect of policy changes. © Health Research and Educational Trust.

  4. Construction of UML class diagram with Model-Driven Development

    OpenAIRE

    Tomasz Górski; Mateusz Sowa

    2016-01-01

    Model transformations play a key role in software development projects based on Model--Driven Development (MDD) principles. Transformations allow for automation of repetitive and well-defined steps, thus shortening design time and reducing a number of errors. In the object-oriented approach, the key elements are use cases. They are described, modelled and later designed until executable application code is obtained. The aim of the paper is to present transformation of a model-to-model type, C...

  5. Leadership Development Model for Shelby County Schools

    Science.gov (United States)

    Cobia, F. Jane; Smith, Elizabeth F.; Wood, Leah Anne

    2016-01-01

    The purpose of this study was to examine factors impacting program quality in leadership development programs as a means to inform the Shelby County School System of effective practices in leadership development. The qualitative research design method was used to explore two school systems identified through a comprehensive review of research as…

  6. Model driven development of user interface prototypes

    DEFF Research Database (Denmark)

    Störrle, Harald

    2010-01-01

    Many approaches to interface development apply only to isolated aspects of the development of user interfaces (UIs), e.g., exploration during the early phases, design of visual appearance, or implementation in some technology. In this paper we explore an _integrated_ approach to incorporate the w...

  7. COMMUNICATION AND RURAL DEVELOPEMENT: A MODEL FOR ...

    African Journals Online (AJOL)

    The failure in developemental endeavours in the rural areas of Africa does not stem substantially from the lack of funds. Rather, other factors conspire to make rural development a difficult task. One of these factors is communication. This paper examines the role of communication in the process of rural development.

  8. Development of a Model Fire Detection Algorithm

    Directory of Open Access Journals (Sweden)

    O. S. Ismail

    2017-06-01

    Full Text Available An adaptive model algorithm for fire (flickering flame, in the infrared region detection is presented. The model made use of a Pyro-electric infrared sensor (PIR/Passive Infrared Detector (PID for infrared fire detection. Sample analog signals (around flame flicker region were generated and simulated within the framework of the modeled PIR sensor/PID. A Joint Time Frequency Analysis (JTFA function, specifically the Discrete Wavelet Transform (DWT was applied to model the Digital Signal Processing (DSP of the generated signals. It was implemented as wavelet analyzer filters for “fire” and “non-fire” feature extraction. A Piecewise Modified Artificial Neural Network (PMANN and the Intraclass Correlation Coefficient (ICC were employed in the decision rule. The PMANN generated polynomials which analyzed and ‘memorized’ the signals from DSP. The ICC further categorized cases as 'fire' or 'non-fire' by comparing data from the PMANN analyzed. The results show that the model algorithm can be implemented in modern day fire detectors and be used to detect industrial hydrocarbon fires with fewer false alarms than smoke detectors or ultraviolet detectors.

  9. A MODEL OF EFL LISTENING MATERIALS DEVELOPMENT

    Directory of Open Access Journals (Sweden)

    Mochamad Zaenuri

    2015-12-01

    Full Text Available In oral communication, listening skill is important because communication does not take place successfully if the message stated is not understood. To master the skill, learners should learn it. Therefore, good listening materials are needed. However, English teachers often find it difficult to teach listening skills because the listening materials are not adequately available. Besides, if the materials are available, they are not appropriate with the students’ needs and the curriculum. In that case, English teachers need to develop listening materials by themselves. For this, they should have knowledge of materials development. This paper presents ideas and tips for English teachers how to develop good and applicable listening materials.

  10. Development and application of air quality models at the US ...

    Science.gov (United States)

    Overview of the development and application of air quality models at the U.S. EPA, particularly focused on the development and application of the Community Multiscale Air Quality (CMAQ) model developed within the Computation Exposure Division (CED) of the National Exposure Research Laboratory (NERL). This presentation will provide a simple overview of air quality model development and application geared toward a non-technical student audience. The National Exposure Research Laboratory (NERL) Computational Exposure Division (CED) develops and evaluates data, decision-support tools, and models to be applied to media-specific or receptor-specific problem areas. CED uses modeling-based approaches to characterize exposures, evaluate fate and transport, and support environmental diagnostics/forensics with input from multiple data sources. It also develops media- and receptor-specific models, process models, and decision support tools for use both within and outside of EPA.

  11. Hydrologic and Water Quality Model Development Using Simulink

    Directory of Open Access Journals (Sweden)

    James D. Bowen

    2014-11-01

    Full Text Available A stormwater runoff model based on the Soil Conservation Service (SCS method and a finite-volume based water quality model have been developed to investigate the use of Simulink for use in teaching and research. Simulink, a MATLAB extension, is a graphically based model development environment for system modeling and simulation. Widely used for mechanical and electrical systems, Simulink has had less use for modeling of hydrologic systems. The watershed model is being considered for use in teaching graduate-level courses in hydrology and/or stormwater modeling. Simulink’s block (data process and arrow (data transfer object model, the copy and paste user interface, the large number of existing blocks, and the absence of computer code allows students to become model developers almost immediately. The visual depiction of systems, their component subsystems, and the flow of data through the systems are ideal attributes for hands-on teaching of hydrologic and mass balance processes to today’s computer-savvy visual learners. Model development with Simulink for research purposes is also investigated. A finite volume, multi-layer pond model using the water quality kinetics present in CE-QUAL-W2 has been developed using Simulink. The model is one of the first uses of Simulink for modeling eutrophication dynamics in stratified natural systems. The model structure and a test case are presented. One use of the model for teaching a graduate-level water quality modeling class is also described.

  12. Parallel Development of Products and New Business Models

    DEFF Research Database (Denmark)

    Lund, Morten; Hansen, Poul H. Kyvsgård

    2014-01-01

    The perception of product development and the practical execution of product development in professional organizations have undergone dramatic changes in recent years. Many of these chances relate to introduction of broader and more cross-disciplinary views that involves new organizational functi...... and innovation management the 4th generation models are increasingly including the concept business models and business model innovation....... functions and new concepts. These chances can be captured in various generations of practice. This paper will discuss the recent development of 3rd generation product development process models and the emergence of a 4th generation. While the 3rd generation models included the concept of innovation...

  13. Recent developments in volatility modeling and applications

    Directory of Open Access Journals (Sweden)

    A. Thavaneswaran

    2006-01-01

    Full Text Available In financial modeling, it has been constantly pointed out that volatility clustering and conditional nonnormality induced leptokurtosis observed in high frequency data. Financial time series data are not adequately modeled by normal distribution, and empirical evidence on the non-normality assumption is well documented in the financial literature (details are illustrated by Engle (1982 and Bollerslev (1986. An ARMA representation has been used by Thavaneswaran et al., in 2005, to derive the kurtosis of the various class of GARCH models such as power GARCH, non-Gaussian GARCH, nonstationary and random coefficient GARCH. Several empirical studies have shown that mixture distributions are more likely to capture heteroskedasticity observed in high frequency data than normal distribution. In this paper, some results on moment properties are generalized to stationary ARMA process with GARCH errors. Application to volatility forecasts and option pricing are also discussed in some detail.

  14. Development of an environmental tritium model; ETDOSE

    Energy Technology Data Exchange (ETDEWEB)

    Andoh, Mariko; Takahashi, Tomoyuki; Amano, Hikaru [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    1999-03-01

    ETDOSE is a simple computer code to calculate atmospheric distribution patterns of tritium for an acute and a chronic release of HT and HTO. This code calculates tritium concentrations in air, soil, plant free water and OBT, and estimates dose impact by inhalation of air and ingestion of food. Participation in IAEA`s model validation program BIOMASS has been done using this code for BIOMASS Scenario 1. This paper shows the outline of ETDOSE and preliminary results of model comparison in BIOMASS program. (author)

  15. Nuclear interaction model developments in FLUKA

    CERN Document Server

    Fontana, A

    2015-01-01

    A selection of recent improvements in the modeling of nuclear interactions with the FLUKA code is presented. At low energy the new features are related to the emission of secondary particles, to the inclusion of spin-parity effects in the evaporation stage and to the extension of the pre-equilibrium step to the Relativistic Quantum Molecular Dynamics (RQMD) model. At high energy new results from Electro-Magnetic Dissociation (EMD) and cosmogenic neutron production are shown. These results confirm and extend the use of FLUKA in different fields of interest, ranging from the LHC to medical applications.

  16. Developing deterioration models for Nebraska bridges.

    Science.gov (United States)

    2011-07-01

    Nebraska Bridge Management System (NBMS) was developed in 1999 to assist in optimizing budget allocation for : the maintenance, rehabilitation and replacement needs of highway bridges. This requires the prediction of bridge : deterioration to calcula...

  17. Catalytic models developed through social work

    DEFF Research Database (Denmark)

    Jensen, Mogens

    2015-01-01

    The article develops the concept of catalytic processes in relation to social work with adolescents in an attempt to both reach a more nuanced understanding of social work and at the same time to develop the concept of catalytic processes in psychology. The social work is pedagogical treatment...... of adolescents placed in out-of-home care and is characterised using three situated cases as empirical data. Afterwards the concept of catalytic processes is briefly presented and then applied in an analysis of pedagogical treatment in the three cases. The result is a different conceptualisation of the social...... work with new possibilities of development of the work, but also suggestions for development of the concept of catalytic processes....

  18. A Conceptual Model of Career Development to Enhance Academic Motivation

    Science.gov (United States)

    Collins, Nancy Creighton

    2010-01-01

    The purpose of this study was to develop, refine, and validate a conceptual model of career development to enhance the academic motivation of community college students. To achieve this end, a straw model was built from the theoretical and empirical research literature. The model was then refined and validated through three rounds of a Delphi…

  19. Report on the model developments in the sectoral assessments

    DEFF Research Database (Denmark)

    Iglesias, Ana; Termansen, Mette; Bouwer, Laurens

    2014-01-01

    The Objective of this Deliverable D3.2 is to describe the models developed in BASE that is, the experimental setup for the sectoral modelling. The model development described in this deliverable will then be implemented in the adaptation and economic analysis in WP6 in order to integrate adaptati...

  20. Development of conceptual groundwater flow model for Pali Area ...

    African Journals Online (AJOL)

    Development of representative conceptual groundwater flow model is an important step before translating it into a numerical model. In this paper, a methodology for development of conceptual groundwater flow model has been presented in which spatially distributed values for groundwater recharge has been utilized ...

  1. A Leadership Identity Development Model: Applications from a Grounded Theory

    Science.gov (United States)

    Komives, Susan R.; Mainella, Felicia C.; Longerbeam, Susan D.; Osteen, Laura; Owen, Julie E.

    2006-01-01

    This article describes a stage-based model of leadership identity development (LID) that resulted from a grounded theory study on developing a leadership identity (Komives, Owen, Longerbeam, Mainella, & Osteen, 2005). The LID model expands on the leadership identity stages, integrates the categories of the grounded theory into the LID model, and…

  2. Wave model for longitudinal dispersion: Development of the model

    Energy Technology Data Exchange (ETDEWEB)

    Westerterp, K.R.; Dil`man, V.V.; Kronberg, A.E. [Twente Univ. of Technology, Enschede (Netherlands)

    1995-09-01

    A new 1-D model for longitudinal dispersion is proposed as an alternative to the Fickian-type dispersed plug-flow model. Accounting for significant features of longitudinal mixing gives rise to a quasilinear hyperbolic system of two first-order equations for the average concentration and the dispersion flux instead of one second-order parabolic equation for the average concentration. The model equations are obtained based on minor extensions of the heuristic equilibrium analysis of Taylor. A qualitative, more general derivation of the equations is given on the basis of a simple generalization of Fick`s law, taking into account the finite velocity of fluid elements. For linear problems the mean concentration and the dispersion flux obey a hyperbolic equation of the second order. The proposed hyperbolic model contains three parameters that depend only on the flow conditions, the physical properties of the fluid, and the geometry of the system. It effectively resolves the well-known problem of boundary conditions that, for unidirectional flow, are formulated now only at the reactor inlet. The new model eliminates the conceptual shortcoming inherent to the Fickian dispersed plug-flow model: it predicts a finite velocity of signal propagation and does not involve backmixing in the case of unidirectional flow.

  3. Object Oriented Modeling : A method for combining model and software development

    NARCIS (Netherlands)

    Van Lelyveld, W.

    2010-01-01

    When requirements for a new model cannot be met by available modeling software, new software can be developed for a specific model. Methods for the development of both model and software exist, but a method for combined development has not been found. A compatible way of thinking is required to

  4. Millimeter Wave Radio Frequency Propagation Model Development

    Science.gov (United States)

    2014-08-28

    Anechoic Chamber .................................. 47  3.4.1  10 GHz Transmitting System...Propagation Losses ............................................................. 67  4.2  Experiment 2 - Quantifying Model Accuracy in an Anechoic Chamber ...44  Figure 20. Actual Footage of the Experiment at 10, 20, 30, and 40 GHz within the Anechoic Chamber

  5. Experimental animal modelling for TB vaccine development

    Directory of Open Access Journals (Sweden)

    Pere-Joan Cardona

    2017-03-01

    Full Text Available Research for a novel vaccine to prevent tuberculosis is an urgent medical need. The current vaccine, BCG, has demonstrated a non-homogenous efficacy in humans, but still is the gold standard to be improved upon. In general, the main indicator for testing the potency of new candidates in animal models is the reduction of the bacillary load in the lungs at the acute phase of the infection. Usually, this reduction is similar to that induced by BCG, although in some cases a weak but significant improvement can be detected, but none of candidates are able to prevent establishment of infection. The main characteristics of several laboratory animals are reviewed, reflecting that none are able to simulate the whole characteristics of human tuberculosis. As, so far, no surrogate of protection has been found, it is important to test new candidates in several models in order to generate convincing evidence of efficacy that might be better than that of BCG in humans. It is also important to investigate the use of “in silico” and “ex vivo” models to better understand experimental data and also to try to replace, or at least reduce and refine experimental models in animals.

  6. High Sustained G-Tolerance Model Development

    Science.gov (United States)

    2002-04-23

    Three-dimensional mathematical model of human hemodynamics”, Cybernetics and Computing Tecnology , N.Y., 1986, No.70, pp. 54-58. 17. Grigoryan R.D. “A...methods and tools or optimize the use of existing tools. In addition, the “PILACCEL” may be used as an educational tool able to show students – pilots

  7. DEVELOPING PREDICTIVE MODELS OF INTERNET SERVICE STRATEGIES

    Directory of Open Access Journals (Sweden)

    Maxim Yu. Khramov

    2015-01-01

    Full Text Available Issues related to strategic managementof interactive online services as well as difficulties in predicting results of strategies’ implementation were studied in the article. As a result methodological andtechnological solutions were workedout; the solutions are based on usage ofsimulation and particularly based on thecombination of such methods as systemdynamics and agent-based modeling.

  8. Model based development of fruit simulators

    Science.gov (United States)

    Huang, Huijian; Tunnicliffe, Mark; Shim, Young-Min; Bronlund, John E.

    2017-10-01

    Optimisation of temperature management in postharvest operations, such as precooling, requires extensive experimental measurement. For this purpose, real fruit are used, but due to their relatively high cost and perishable nature, commercial scale trials are not easily conducted. In addition, significant variability between trials exists (Vigneault et al., 2005). Physical fruit analogues or simulators could provide a solution to overcome these issues. To be a solution the fruit simulators must be designed to mimic the relevant heat transfer modes and properties of individual and/or bulk fruit, ideally using an inexpensive and durable material that allows the fruit simulator to be mass produced (Redding et al., 2016). In this paper, we use a mathematical model to characterize the relative importance of the different heat transfer modes occurring during precooling. Based on this model, the modes of heat transfer that must be matched by the fruit simulator are identified. A simplified model is used, representing four fruit stacked on top of each other in a column. The contribution of each heat transfer mode can be evaluated by including or excluding terms in the model.

  9. Developing consistent pronunciation models for phonemic variants

    CSIR Research Space (South Africa)

    Davel, M

    2006-09-01

    Full Text Available from a lexicon containing variants. In this paper we (the authors) address both these issues by creating ‘pseudo-phonemes’ associated with sets of ‘generation restriction rules’ to model those pronunciations that are consistently realised as two or more...

  10. Developing Novel Explanatory Models for Electronics Education

    Science.gov (United States)

    Pule, Sarah; McCardle, John

    2010-01-01

    This paper explores how representations of technological concepts may be designed to help students with visual learning styles achieve successful comprehension in the field of electronics. The work accepts a wide definition of what is understood by the visualisation of a model in that it can take different external forms, but also include an…

  11. Computational Modelling of Cancer Development and Growth: Modelling at Multiple Scales and Multiscale Modelling.

    Science.gov (United States)

    Szymańska, Zuzanna; Cytowski, Maciej; Mitchell, Elaine; Macnamara, Cicely K; Chaplain, Mark A J

    2017-06-20

    In this paper, we present two mathematical models related to different aspects and scales of cancer growth. The first model is a stochastic spatiotemporal model of both a synthetic gene regulatory network (the example of a three-gene repressilator is given) and an actual gene regulatory network, the NF-[Formula: see text]B pathway. The second model is a force-based individual-based model of the development of a solid avascular tumour with specific application to tumour cords, i.e. a mass of cancer cells growing around a central blood vessel. In each case, we compare our computational simulation results with experimental data. In the final discussion section, we outline how to take the work forward through the development of a multiscale model focussed at the cell level. This would incorporate key intracellular signalling pathways associated with cancer within each cell (e.g. p53-Mdm2, NF-[Formula: see text]B) and through the use of high-performance computing be capable of simulating up to [Formula: see text] cells, i.e. the tissue scale. In this way, mathematical models at multiple scales would be combined to formulate a multiscale computational model.

  12. Enabling Accessibility Through Model-Based User Interface Development.

    Science.gov (United States)

    Ziegler, Daniel; Peissner, Matthias

    2017-01-01

    Adaptive user interfaces (AUIs) can increase the accessibility of interactive systems. They provide personalized display and interaction modes to fit individual user needs. Most AUI approaches rely on model-based development, which is considered relatively demanding. This paper explores strategies to make model-based development more attractive for mainstream developers.

  13. A model for developing disability confidence.

    Science.gov (United States)

    Lindsay, Sally; Cancelliere, Sara

    2017-05-15

    Many clinicians, educators, and employers lack disability confidence which can affect their interactions with, and inclusion of people with disabilities. Our objective was to explore how disability confidence developed among youth who volunteered with children who have a disability. We conducted 30 in-depth interviews (16 without a disability, 14 with disabilities), with youth aged 15-25. We analyzed our data using an interpretive, qualitative, thematic approach. We identified four main themes that led to the progression of disability confidence including: (1) "disability discomfort," referring to lacking knowledge about disability and experiencing unease around people with disabilities; (2) "reaching beyond comfort zone" where participants increased their understanding of disability and became sensitized to difference; (3) "broadened perspectives" where youth gained exposure to people with disabilities and challenged common misperceptions and stereotypes; and (4) "disability confidence" which includes having knowledge of people with disabilities, inclusive, and positive attitudes towards them. Volunteering is one way that can help to develop disability confidence. Youth with and without disabilities both reported a similar process of developing disability confidence; however, there were nuances between the two groups. Implications for Rehabilitation The development of disability confidence is important for enhancing the social inclusion of people with disabilities. Volunteering with people who have a disability, or a disability different from their own, can help to develop disability confidence which involves positive attitudes, empathy, and appropriate communication skills. Clinicians, educators, and employers should consider promoting working with disabled people through such avenues as volunteering or service learning to gain disability confidence.

  14. Criteria Assessment Model for Sustainable Product Development

    Science.gov (United States)

    Mohd Turan, Faiz; Johan, Kartina; Hisyamudin Muhd Nor, Nik

    2016-11-01

    The instability in today's market and the ever increasing and emerging demands for mass customized and hybrid products by customers, are driving companies and decision makers to seek for cost effective and time efficient improvements in their product development process. Design concept evaluation which is the end of conceptual design is one of the most critical decision points in product development. It relates to the final success of product development, because poor criteria assessment in design concept evaluation can rarely compensated at the later stages. This has led to real pressure for the adaptation of new developmental architecture and operational parameters to remain competitive in the market. In this paper, a new integrated design concept evaluation based on fuzzy-technique for order preference by similarity to ideal solution (Fuzzy-TOPSIS) is presented, and it also attempts to incorporate sustainability practices in assessing the criteria. Prior to Fuzzy-TOPSIS, a new scale of “Weighting criteria” for survey process is developed to quantify the evaluation criteria. This method will help engineers to improve the effectiveness and objectivity of the sustainable product development. Case example from industry is presented to demonstrate the efficacy of the proposed methodology. The result of the example shows that the new integrated method provides an alternative to existing methods of design concept evaluation.

  15. Advances in Model-based Downstream Process Development

    OpenAIRE

    Hahn, Tobias

    2015-01-01

    This thesis consists of nine publications and manuscripts that focus on different aspects of chromatography modeling, model calibration and model-based process development. The first four manuscripts present results generated with novel computational methods, the following five are case studies of model-calibration and process optimization.

  16. Developing a Drosophila Model of Schwannomatosis

    Science.gov (United States)

    2012-08-01

    Foundation NF Conference in New Orleans (June 9th-12th 2012) • Published review in Disease Models and Mechanisms on ‘Modeling tumor Invasion and...which was obtained by mating rbf1D14/FM7, GFP virgins to rbf1120a/FM7, GFP males at 18uC. Similarly, the genotype of CAP-D3 mutants was a...transheterozygous combination of dCAP-D3D25/dCAP-D3c07081 which was obtained by mating dCAP-D3D25/CyO, GFP virgins to dCAP-D3c07081/CyO, GFP males at 23uC. yolk

  17. Internal Branding Implementation: Developing a Conceptual Model

    OpenAIRE

    Katja Terglav; Robert Kase; Maja Konecnik Ruzzier

    2012-01-01

    Internal branding is the process, which enables balanced view of the brand at all company levels. Its significance is aligning values and behaviors of employees with brand values and brand promises. In the article, we focus mainly on its implementation, which requires coordination of different functions in the company, for instance, internal marketing and human resource management. Based on findings of qualitative research, we present a conceptual model of internal branding implementation. Re...

  18. Developing model asphalt systems using molecular simulation : final model.

    Science.gov (United States)

    2009-09-01

    Computer based molecular simulations have been used towards developing simple mixture compositions whose : physical properties resemble those of real asphalts. First, Monte Carlo simulations with the OPLS all-atom force : field were used to predict t...

  19. A Lattice Model of the Development of Reading Comprehension.

    Science.gov (United States)

    Connor, Carol McDonald

    2016-12-01

    In this article, I present a developmental model of how children learn to comprehend what they read, which builds on current models of reading comprehension and integrates findings from instructional research and evidence-based models of development in early and middle childhood. The lattice model holds that children's developing reading comprehension is a function of the interacting, reciprocal, and bootstrapping effects of developing text-specific, linguistic, and social-cognitive processes, which interact with instruction as child-characteristic-by-instruction (CXI) interaction effects. The processes develop over time and in the context of classroom, home, peer, community, and other influences to affect children's development of proficient reading comprehension. I first describe models of reading comprehension. I then review the basic processes in the model, the role of instruction, and CXI interactions in the context of the lattice model. I then discuss implications for instruction and research.

  20. Model driven engineering and ontology development

    CERN Document Server

    Gasevic, Dragan; Devedzic, Vladan; Bézivin, Jean; Selic, Bran

    2009-01-01

    Describes technologies, tools, and standards like XML, RDF, OWL, MDA, and UML. This book describes OMG's ODM (Ontology Definition Metamodel) initiative, a specification which is in the form of an OMG language like UML. It also covers applications and practical aspects of developing ontologies using MDA-based languages.

  1. Research and Development Project Prioritization - Computer Model

    Science.gov (United States)

    1980-04-01

    one. from the different methods. Three Kendali methods The Fuzzy set matrix, rank oLder, and evaluation were chosen for the evaluations: computations...Command ATTN: Technical Director 1 0 St. Louis, MO Commander US Army Mobility Equipment Research and Development Command ATTN: Technical Director 1 Fort

  2. Evaluation model development for sprinkler irrigation uniformity ...

    African Journals Online (AJOL)

    A new evaluation method with accompanying software was developed to precisely calculate uniformity from catch-can test data, assuming sprinkler distribution data to be a continuous variable. Two interpolation steps are required to compute unknown water application depths at grid distribution points from radial ...

  3. Addressing Development Vision 2025: Appropriate Training Models ...

    African Journals Online (AJOL)

    Appropriately trained Human Resources for Health (HRH) are key inputs in the realisation of high quality livelihood, the first attribute of Tanzania‟s Development Vision 2025. Within this attribute elements related to HRH include: access to quality primary health care for all, reduction in infant and maternal mortality rates by ...

  4. Sustainability Assessment Model in Product Development

    Science.gov (United States)

    Turan, Faiz Mohd; Johan, Kartina; Nor, Nik Hisyamudin Muhd; Omar, Badrul

    2017-08-01

    Faster and more efficient development of innovative and sustainable products has become the focus for manufacturing companies in order to remain competitive in today’s technologically driven world. Design concept evaluation which is the end of conceptual design is one of the most critical decision points. It relates to the final success of product development, because poor criteria assessment in design concept evaluation can rarely compensated at the later stages. Furthermore, consumers, investors, shareholders and even competitors are basing their decisions on what to buy or invest in, from whom, and also on what company report, and sustainability is one of a critical component. In this research, a new methodology of sustainability assessment in product development for Malaysian industry has been developed using integration of green project management, new scale of “Weighting criteria” and Rough-Grey Analysis. This method will help design engineers to improve the effectiveness and objectivity of the sustainable design concept evaluation, enable them to make better-informed decisions before finalising their choice and consequently create value to the company or industry. The new framework is expected to provide an alternative to existing methods.

  5. Development of condensation modeling modeling and simulation code for IRWST

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Sang Nyung; Jang, Wan Ho; Ko, Jong Hyun; Ha, Jong Baek; Yang, Chang Keun; Son, Myung Seong [Kyung Hee Univ., Seoul (Korea)

    1997-07-01

    One of the design improvements of the KNGR(Korean Next Generation Reactor) which is advanced to safety and economy is the adoption of IRWST(In-Containment Refueling Water Storage Tank). The IRWST, installed inside of the containment building, has more designed purpose than merely the location change of the tank. Since the design functions of the IRWST is similar to these of the BWR's suppression pool, theoretical models applicable to BWR's suppression pool can be mostly applied to the IRWST. But for the PWR, the geometry of the sparger, the operation mode and the steam quantity and temperature and pressure of discharged fluid from primary system to IRWST through PSV or SDV may be different from those of BWR. Also there is some defects in detailed parts of condensation model. Therefore we, as the first nation to construct PWR with IRWST, must carry out profound research for there problems such that the results can be utilized and localized as an exclusive technology. All kinds of thermal hydraulics phenomena was investigated and existing condensation models by Hideki Nariai and Izuo Aya were analyzed. Also throuh a rigorous literature review such as operation experience, experimental data, design document of KNGR, items which need modification and supplementation were derived. Analytical model for chugging phenomena is also presented. 15 refs., 18 figs., 4 tabs. (Author)

  6. A model for the development of university curricula in nanoelectronics

    DEFF Research Database (Denmark)

    Bruun, Erik; Nielsen, I

    2010-01-01

    Nanotechnology is having an increasing impact on university curricula in electrical engineering and in physics. Major influencers affecting developments in university programmes related to nanoelectronics are discussed and a model for university programme development is described. The model takes...... into account that nanotechnology affects not only physics but also electrical engineering and computer engineering because of the advent of new nanoelectronics devices. The model suggests that curriculum development tends to follow one of three major tracks: physics; electrical engineering; computer...

  7. Testing Neural Models of the Development of Infant Visual Attention

    OpenAIRE

    Richards, John E.; Hunter, Sharon K.

    2002-01-01

    Several models of the development of infant visual attention have used information about neural development. Most of these models have been based on nonhuman animal studies and have relied on indirect measures of neural development in human infants. This article discusses methods for studying a “neurodevelopmental” model of infant visual attention using indirect and direct measures of cortical activity. We concentrate on the effect of attention on eye movement control and show how animal-base...

  8. Capability Based Decision Model of Attribution: Empirical Development in Iran

    OpenAIRE

    Khan, T.; Ghalamchi, P

    2015-01-01

    This study aims to improve the reliability of existing attribution processes by developing a decision model that is inspired by Sen's (1999) Capability Approach (CA) and Weiner’s (1995) Attribution Theory. The model is intended to provide a more complete representation of the decision maker’s state of self-determination, than currently is possible, as it influences their decisions. This paper presents the theoretical model and discusses the empirical development of the model from a process of...

  9. Towards a national cybersecurity capability development model

    CSIR Research Space (South Africa)

    Jacobs, Pierre C

    2017-06-01

    Full Text Available models are the Insurance Application Architecture (IAA) (IBM, 2009b), the Banking Industry Architecture Network (BIAN) (BIAN, 2016), the Information Framework (IFW) (IBM, 2009a), ITIL (Roth, 2008) and CoBIT (Spafford, G., Wheeler, A. J. & Mingay, 2012... Architecture (IAA). Retrieved October 4, 2016, from http://www.ibm.com/support/knowledgecenter/SSAVUV_7.0.0/com.ibm.ws.icp.insp_cfep1.doc/ins/pc/ p_cdev/concept/ci/indstds/c_iaa.html ISO/IEC. (2011). ISO/IEC 27035:2011 Information technology — Security...

  10. Experiments for foam model development and validation.

    Energy Technology Data Exchange (ETDEWEB)

    Bourdon, Christopher Jay; Cote, Raymond O.; Moffat, Harry K.; Grillet, Anne Mary; Mahoney, James F. (Honeywell Federal Manufacturing and Technologies, Kansas City Plant, Kansas City, MO); Russick, Edward Mark; Adolf, Douglas Brian; Rao, Rekha Ranjana; Thompson, Kyle Richard; Kraynik, Andrew Michael; Castaneda, Jaime N.; Brotherton, Christopher M.; Mondy, Lisa Ann; Gorby, Allen D.

    2008-09-01

    A series of experiments has been performed to allow observation of the foaming process and the collection of temperature, rise rate, and microstructural data. Microfocus video is used in conjunction with particle image velocimetry (PIV) to elucidate the boundary condition at the wall. Rheology, reaction kinetics and density measurements complement the flow visualization. X-ray computed tomography (CT) is used to examine the cured foams to determine density gradients. These data provide input to a continuum level finite element model of the blowing process.

  11. Enhancing System Realisation in Formal Model Development

    DEFF Research Database (Denmark)

    Tran-Jørgensen, Peter Würtz Vinther

    – a formal methods tool that supports the Vienna Development Method. The development of the code generation infrastructure has involved the re-design of the software architecture of Overture. The new architecture brings forth the reuse and extensibility features of Overture to take into account the needs......Software for mission-critical systems is sometimes analysed using formal specification to increase the chances of the system behaving as intended. When sufficient insights into the system have been obtained from the formal analysis, the formal specification is realised in the form of a software...... implementation. One way to realise the system’s software is by automatically generating it from the formal specification – a technique referred to as code generation. However, in general it is difficult to make guarantees about the correctness of the generated code – especially while requiring automation...

  12. Development of Animal Models of Otitis Media

    OpenAIRE

    Park, Moo Kyun; Lee, Byung Don

    2013-01-01

    Otitis media is defined as inflammation of the middle ear, including the auditory ossicles and the Eustachian tube. Otitis media is a major health problem in many societies. The causes of otitis media includes infection and anatomic/physiologic, host, and environmental factors. In general, otitis media is a childhood disease, and anatomic and physiologic changes have great effects on its development. Thus, in vitro or human experimental studies of otitis media are difficult. Several experimen...

  13. Methodology for structured VHDL model development

    OpenAIRE

    Gummadi, Ram

    1995-01-01

    The Rapid Prototyping of Application Specific Signal Processors (RASSP) program seeks an improvement in the time required to take a design from concept to fielded prototype or to upgrade an existing design, with similar improvements in design quality and life cycle cost. The term Rapid System Prototyping signifies the need to develop systems in significantly less time or with significantly less effort, and thus provides a solution to the main problem facing the design community...

  14. Transducer Analysis and ATILA++ Model Development

    Science.gov (United States)

    2016-10-10

    Field measurement apparatus Thermal and frequency dependence of properties of passive materials A technique was developed to adapt Resonant Ultrasound ...the stress and temperature dependent properties of the active materials involved. Predicting performance of these devices under demanding environments...addresses the need to predict the performance of these devices by considering the highly non- linear behavior with a fully non-linear solution procedure in

  15. Army Systems Engineering Career Development Model

    Science.gov (United States)

    2015-01-15

    technical-business enterprise; building, developing, sustaining and leading teams; and designing and leading change. Core Training: Consider ‘ leaning ’ the...observations began to take shape, it became increasingly clear that the findings and recommendations were, on balance , not stand alone ‘vectors,’ due to the...serve as scorecard for goals and progress, and can additionally be customized for acquisition effectiveness through the convergence of the specific

  16. Ecotourism – model of sustainable tourist development

    Directory of Open Access Journals (Sweden)

    Mirela Stefanica

    2010-12-01

    Full Text Available In the last years, the tendency in the tourism industry was that of return towards nature and towards the authentic cultural values. Among all the forms of tourism, ecotourism distinguishes itself through the strongest connection with the natural and cultural environment, representing the most valuable form of manifestation of sustainable tourism, with the fastest growth rhythm worldwide. Integrated in the sustainable development, ecotourism involves activities that directly contribute to the nature protection and to keeping the old human creations unaltered.

  17. Model Development for Atomic Force Microscope Stage Mechanisms

    National Research Council Canada - National Science Library

    Smith, Ralph C; Hatch, Andrew G; De, Tathagata; Salapaka, Murti V; Raye, Julie K; del Rosario, Ricardo C

    2005-01-01

    In this paper, we develop nonlinear constitutive equations and resulting system models quantifying the nonlinear and hysteretic field-displacement relations inherent to lead zirconate titanate (PZT...

  18. Modelling Template for the Development of the Process Flowsheet

    DEFF Research Database (Denmark)

    Fedorova, Marina; Gani, Rafiqul

    2015-01-01

    provides building blocks for the templates (generic models previously developed); 3) computer aided methods and tools, that include procedures to perform model translation, model analysis, model verification/validation, model solution and model documentation. In this work, the integrated use of all three......Models are playing important roles in design and analysis of chemicals/bio-chemicals based products and the processes that manufacture them. Model-based methods and tools have the potential to decrease the number of experiments, which can be expensive and time consuming, and point to candidates...

  19. Materials Database Development for Ballistic Impact Modeling

    Science.gov (United States)

    Pereira, J. Michael

    2007-01-01

    A set of experimental data is being generated under the Fundamental Aeronautics Program Supersonics project to help create and validate accurate computational impact models of jet engine impact events. The data generated will include material property data generated at a range of different strain rates, from 1x10(exp -4)/sec to 5x10(exp 4)/sec, over a range of temperatures. In addition, carefully instrumented ballistic impact tests will be conducted on flat plates and curved structures to provide material and structural response information to help validate the computational models. The material property data and the ballistic impact data will be generated using materials from the same lot, as far as possible. It was found in preliminary testing that the surface finish of test specimens has an effect on measured high strain rate tension response of AL2024. Both the maximum stress and maximum elongation are greater on specimens with a smoother finish. This report gives an overview of the testing that is being conducted and presents results of preliminary testing of the surface finish study.

  20. Use of models and modelling techniques for service development

    NARCIS (Netherlands)

    Mendes, M.J.; Ferreira Pires, Luis; Suomi, R.; van Sinderen, Marten J.; Guareis de farias, Cléver; Passos, C.; Andrade Almeida, João

    2004-01-01

    E-applications are increasingly being composed from individual services that can be realized with different technologies, such as, e.g., Web Services and standard component technologies. A current trend in the development of these services is to describe their technology-independent and

  1. Use of Models and Modelling Techniques for Service Development

    NARCIS (Netherlands)

    Ferreira Pires, Luis; van Sinderen, Marten J.; Guareis de farias, Cléver; Andrade Almeida, João

    E-applications are increasingly being composed from individual services that can be realized with different technologies, such as, e.g., Web Services and standard component technologies. A current trend in the development of these services is to describe their technology-independent and

  2. Models of Integration, Models of Development in the Pacific

    Directory of Open Access Journals (Sweden)

    John Borrego

    1995-08-01

    Full Text Available In order to understand the processes related to integration and development in the East Asian and Latin American societies this paper attempts to place those processes in the larger context of cycles of world accumulation. Many of the societies in East Asia, Latin America, and the South, in general, were integrated into the world economy during previous cycles of hegemony and accumulation. However, in the American cycle, and particularly at the height of this cycle, East Asia was developed while most of Latin America continued to experience truncated development. How do we understand these different trajectories? We argue that the best way to understand the different processes of integration and development in these two regions during the current historical period of global capitalist accumulation is to see them all as housed in a transition period between the waning American cycle of hegemony in the world economy and a new, as yet undefined cycle. We will look at the role that the East Asian region and its societies are playing in the transition to the next cycle, as well as analyze why these societies should not be viewed as successful products of the "modernization process," as proponents of that theory argue. The "success" of these societies is rooted in their historical entry point and the geopolitical importance to the United States of the region in which they were housed, and is not necessarily repeatable by other Third World societies such as those in Latin America.

  3. The Development of an Organisational Redesign Model

    Directory of Open Access Journals (Sweden)

    Johann Burden

    2009-03-01

    Full Text Available The objective of this study was twofold: Firstly, to explore and describe the perceived fairness of a disciplinary procedure in the workplace and, secondly, to develop guidelines that could be used by managers to provide a fairer experience of the disciplinary procedure. A qualitative research design was employed. In-depth interviews were conducted with participants who were purposely divided into two groups (an employee participant group and an expert participant group. Results indicated that employees experienced the disciplinary procedure as traumatic, unfair and not reliable. Guidelines were formulated to manage employee discipline more effectively.

  4. A Scandinavian Model of Innovative Product Development

    DEFF Research Database (Denmark)

    McAloone, Timothy Charles; Andreasen, Mogens Myrup; Boelskifte, Per

    2007-01-01

    competencies. We reflect on our efforts to produce a new type of design professionalism, pointing to new roles and identities for the professional-ism of synthesis and innovation. Finally, we round up by articulating what we see as the future pattern of product development, which should be sup-ported already......The educational systems in the small Scandinavian countries are open to experiments and new education programmes. This paper presents such an initiative from Denmark, showing new interpretations of industrial needs, research insights, educational ideas and identification of core innovative...

  5. Developing a Successful Open Source Training Model

    Directory of Open Access Journals (Sweden)

    Belinda Lopez

    2010-01-01

    Full Text Available Training programs for open source software provide a tangible, and sellable, product. A successful training program not only builds revenue, it also adds to the overall body of knowledge available for the open source project. By gathering best practices and taking advantage of the collective expertise within a community, it may be possible for a business to partner with an open source project to build a curriculum that promotes the project and supports the needs of the company's training customers. This article describes the initial approach used by Canonical, the commercial sponsor of the Ubuntu Linux operating system, to engage the community in the creation of its training offerings. We then discuss alternate curriculum creation models and some of the conditions that are necessary for successful collaboration between creators of existing documentation and commercial training providers.

  6. Computer-Aided Template for Model Reuse, Development and Maintenance

    DEFF Research Database (Denmark)

    Fedorova, Marina; Sin, Gürkan; Gani, Rafiqul

    2014-01-01

    A template-based approach for model development is presented in this work. Based on a model decomposition technique, the computer-aided template concept has been developed. This concept is implemented as a software tool , which provides a user-friendly interface for following the workflow steps......, as well as the guidance through the steps providing additional information and comments. The application of the tool is highlighted with a multiscale modeling case study involving a catalytic membrane fixed bed reactor. The modeling templates for reactor as well as particle scales have been developed...... . For the particle scale, two alternative mechanisms to describe the diffusion inside catalyst pellets are available: a Fickian diffusion model and a dusty gas model . Moreover, the effects of isothermal and non-isothermal catalyst are also considered during the model development process. Thereby, any number...

  7. Modeling the connection between development and evolution: Preliminary report

    Energy Technology Data Exchange (ETDEWEB)

    Mjolsness, E.; Reinitz, J. [Yale Univ., New Haven, CT (United States); Garrett, C.D. [Washington Univ., Seattle, WA (United States). Dept. of Computer Science; Sharp, D.H. [Los Alamos National Lab., NM (United States)

    1993-07-29

    In this paper we outline a model which incorporates development processes into an evolutionary frame work. The model consists of three sectors describing development, genetics, and the selective environment. The formulation of models governing each sector uses dynamical grammars to describe processes in which state variables evolve in a quantitative fashion, and the number and type of participating biological entities can change. This program has previously been elaborated for development. Its extension to the other sectors of the model is discussed here and forms the basis for further approximations. A specific implementation of these ideas is described for an idealized model of the evolution of a multicellular organism. While this model doe not describe an actual biological system, it illustrates the interplay of development and evolution. Preliminary results of numerical simulations of this idealized model are presented.

  8. Computational Modeling Develops Ultra-Hard Steel

    Science.gov (United States)

    2007-01-01

    Glenn Research Center's Mechanical Components Branch developed a spiral bevel or face gear test rig for testing thermal behavior, surface fatigue, strain, vibration, and noise; a full-scale, 500-horsepower helicopter main-rotor transmission testing stand; a gear rig that allows fundamental studies of the dynamic behavior of gear systems and gear noise; and a high-speed helical gear test for analyzing thermal behavior for rotorcraft. The test rig provides accelerated fatigue life testing for standard spur gears at speeds of up to 10,000 rotations per minute. The test rig enables engineers to investigate the effects of materials, heat treat, shot peen, lubricants, and other factors on the gear's performance. QuesTek Innovations LLC, based in Evanston, Illinois, recently developed a carburized, martensitic gear steel with an ultra-hard case using its computational design methodology, but needed to verify surface fatigue, lifecycle performance, and overall reliability. The Battelle Memorial Institute introduced the company to researchers at Glenn's Mechanical Components Branch and facilitated a partnership allowing researchers at the NASA Center to conduct spur gear fatigue testing for the company. Testing revealed that QuesTek's gear steel outperforms the current state-of-the-art alloys used for aviation gears in contact fatigue by almost 300 percent. With the confidence and credibility provided by the NASA testing, QuesTek is commercializing two new steel alloys. Uses for this new class of steel are limitless in areas that demand exceptional strength for high throughput applications.

  9. Development of 3D Oxide Fuel Mechanics Models

    Energy Technology Data Exchange (ETDEWEB)

    Spencer, B. W. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Casagranda, A. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Pitts, S. A. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Jiang, W. [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2017-07-27

    This report documents recent work to improve the accuracy and robustness of the mechanical constitutive models used in the BISON fuel performance code. These developments include migration of the fuel mechanics models to be based on the MOOSE Tensor Mechanics module, improving the robustness of the smeared cracking model, implementing a capability to limit the time step size based on material model response, and improving the robustness of the return mapping iterations used in creep and plasticity models.

  10. Modeling microstructural development during the forging of Waspaloy

    Science.gov (United States)

    Shen, Gangshu; Semiatin, S. L.; Shivpuri, Rajiv

    1995-07-01

    A model for predicting the evolution of microstructure in Waspaloy during thermomechanical proc-essing was developed in terms of dynamic recrystallization (DRX), metadynamic recrystallization, and grain growth phenomena. Three sets of experiments were conducted to develop the model: (1) preheating tests to model grain growth prior to hot deformation; (2) compression tests in a Gleeble testing machine with different deformation and cooling conditions to model DRX, metadynamic recrystallization, and short time grain growth during the post deformation dwell period and cooling; and (3) pancake and closed die forging tests conducted in a manufacturing environment to verify and refine the model. The microstructural model was combined with finite element modeling (FEM) to predict microstructure development during forging of Waspaloy. Model predictions showed good agreement with microstructures obtained in actual isothermal and hammer forgings carried out at a forging shop.

  11. Development of EMT Simulation Model to Use RMS Control Model

    OpenAIRE

    Kalikavunkal, Priya

    2016-01-01

    Evolution is continuous and as a result, developments in semiconductors are endless. This led to the Voltage Source Converter (VSC) based High Voltage Direct Current (HVDC) converter termed as HVDC light. HVDC light is quite preferable because of its pros in the technology used as well as the application it is used for. For instance, the VSC technology allows independent control of the real and reactive power and has reduced short circuit current. HVDC light are used in applications such as w...

  12. METHODOLOGICAL APPROACHES FOR MODELING THE RURAL SETTLEMENT DEVELOPMENT

    Directory of Open Access Journals (Sweden)

    Gorbenkova Elena Vladimirovna

    2017-10-01

    Full Text Available Subject: the paper describes the research results on validation of a rural settlement developmental model. The basic methods and approaches for solving the problem of assessment of the urban and rural settlement development efficiency are considered. Research objectives: determination of methodological approaches to modeling and creating a model for the development of rural settlements. Materials and methods: domestic and foreign experience in modeling the territorial development of urban and rural settlements and settlement structures was generalized. The motivation for using the Pentagon-model for solving similar problems was demonstrated. Based on a systematic analysis of existing development models of urban and rural settlements as well as the authors-developed method for assessing the level of agro-towns development, the systems/factors that are necessary for a rural settlement sustainable development are identified. Results: we created the rural development model which consists of five major systems that include critical factors essential for achieving a sustainable development of a settlement system: ecological system, economic system, administrative system, anthropogenic (physical system and social system (supra-structure. The methodological approaches for creating an evaluation model of rural settlements development were revealed; the basic motivating factors that provide interrelations of systems were determined; the critical factors for each subsystem were identified and substantiated. Such an approach was justified by the composition of tasks for territorial planning of the local and state administration levels. The feasibility of applying the basic Pentagon-model, which was successfully used for solving the analogous problems of sustainable development, was shown. Conclusions: the resulting model can be used for identifying and substantiating the critical factors for rural sustainable development and also become the basis of

  13. Model Transformation for Model Driven Development of Semantic Web Enabled Multi-Agent Systems

    NARCIS (Netherlands)

    Kardas, G.; Göknil, Arda; Dikenelli, O.; Topaloglu, N.Y.; Weyns, D.; Holvoet, T.

    2007-01-01

    Model Driven Development (MDD) provides an infrastructure that simplifies Multi-agent System (MAS) development by increasing the abstraction level. In addition to defining models, transformation process for those models is also crucial in MDD. On the other hand, MAS modeling should also take care of

  14. Nuclear energy, renewable energy, and economic growth in developed and developing countries : A modelling analysis from simultaneous-equation models

    OpenAIRE

    Anis Omri; Anissa Chaibi

    2014-01-01

    This paper investigates the causal relationship among two types of energy consumption (nuclear energy and renewable energy) and economic growth using dynamic simultaneous-equation panel data models for 17 developed and developing countries. Our results in

  15. Modeling Root Depth Development with time under some Crop and ...

    African Journals Online (AJOL)

    Five empirical models for the prediction of root depth developed with time under four combinations of crop and tillage management systems have been developed by the method of polynomial regression. Root depth predictions by a general model were severally correlated with root depth predictions by the ...

  16. Mentoring Model for Lecturers' Research Skills Development: Case ...

    African Journals Online (AJOL)

    The purpose of this study was to establish an appropriate model which can be applied to develop research skills for lecturers. The study was guided by a qualitative research philosophy. Data were gathered at two levels. First, a critical literature review for possible models for developing research for skills lectures. This was ...

  17. Application of the IPI Model to a Perceptual Development Curriculum.

    Science.gov (United States)

    Rosner, Jerome

    The Individually Prescribed Instruction (IPI) Model developed by Bolvin and Glaser (1968) is applied to a perceptual development curriculum for children manifesting learning disabilities. The Model utilizes criterion referenced tests for behavioral objectives in four areas: general motor, visual motor, auditory motor, and integrative. Eight units…

  18. Advanced reach tool (ART) : Development of the mechanistic model

    NARCIS (Netherlands)

    Fransman, W.; Tongeren, M. van; Cherrie, J.W.; Tischer, M.; Schneider, T.; Schinkel, J.; Kromhout, H.; Warren, N.; Goede, H.; Tielemans, E.

    2011-01-01

    This paper describes the development of the mechanistic model within a collaborative project, referred to as the Advanced REACH Tool (ART) project, to develop a tool to model inhalation exposure for workers sharing similar operational conditions across different industries and locations in Europe.

  19. Child human model development: a hybrid validation approach

    NARCIS (Netherlands)

    Forbes, P.A.; Rooij, L. van; Rodarius, C.; Crandall, J.

    2008-01-01

    The current study presents a development and validation approach of a child human body model that will help understand child impact injuries and improve the biofidelity of child anthropometric test devices. Due to the lack of fundamental child biomechanical data needed to fully develop such models a

  20. Development of computer simulation models for pedestrian subsystem impact tests

    NARCIS (Netherlands)

    Kant, R.; Konosu, A.; Ishikawa, H.

    2000-01-01

    The European Enhanced Vehicle-safety Committee (EEVC/WG10 and WG17) proposed three component subsystem tests for cars to assess pedestrian protection. The objective of this study is to develop computer simulation models of the EEVC pedestrian subsystem tests. These models are available to develop a

  1. School Nurse Summer Institute: A Model for Professional Development

    Science.gov (United States)

    Neighbors, Marianne; Barta, Kathleen

    2004-01-01

    The components of a professional development model designed to empower school nurses to become leaders in school health services is described. The model was implemented during a 3-day professional development institute that included clinical and leadership components, especially coalition building, with two follow-up sessions in the fall and…

  2. Developing Transferable Skills in Undergraduate Mathematics Students through Mathematical Modelling.

    Science.gov (United States)

    Nyman, Melvin A.; Berry, John

    2002-01-01

    Discusses certain transferable skills and a strategy for developing them via an intensive short course on mathematical modeling. Includes student reactions and comments on the course. Suggests that this course developed modeling as well as generic skills through teaching, learning, and assessment style. (Author/KHR)

  3. A Model for the Development of University Curricula in Nanoelectronics

    Science.gov (United States)

    Bruun, E.; Nielsen, I.

    2010-01-01

    Nanotechnology is having an increasing impact on university curricula in electrical engineering and in physics. Major influencers affecting developments in university programmes related to nanoelectronics are discussed and a model for university programme development is described. The model takes into account that nanotechnology affects not only…

  4. The development of a model for dealing with secondary traumatic ...

    African Journals Online (AJOL)

    Jean Damascène Iyamuremye

    Rwanda is well-known for the 1994 genocide, with the death of ... to manage STS in mental health workers in Rwanda at the individual, social and organ- isational levels. ... 2. Development of the model. The Intervention Model to Manage Secondary Traumatic. Stress (IMMSTS) was developed by using an action research.

  5. Model-based scenarios for rural electrification in developing countries

    NARCIS (Netherlands)

    Ruijven, B. van; Schers, J.; Vuuren, D.P. van

    2012-01-01

    Promoting access to modern energy forms in developing countries to replace traditional fuels is high on the political agenda. This paper describes the development and application of a global model for rural electrification. The model is used to assess future trends in electrification, and the

  6. Development of an in vitro burn wound model

    NARCIS (Netherlands)

    Coolen, N.A.; Vlig, M.; van den Bogaerdt, A.J.; Middelkoop, E.; Ulrich, M.

    2008-01-01

    Healing of a deeper burn wound is a complex process that often leads to scar formation. Skin wound model systems are important for the development of treatments preventing scarring. The aim of this study is to develop a standardized in vitro burn wound model that resembles the in vivo situation. A

  7. Energy modelling towards low carbon development of Beijing in 2030

    DEFF Research Database (Denmark)

    Zhao, Guangling; Guerrero, Josep M.; Jiang, Kejun

    2017-01-01

    PLAN, an energy system analysis tool, is chosen to develop the reference energy model. Secondly, this reference model is used to investigate the alternative energy system for integrating renewable energies. Three scenarios are developed towards the energy system of Beijing in 2030, which are: (i) reference...

  8. Developing Pre-Service Teachers' Technology Integration Expertise through the TPACK-Developing Instructional Model

    Science.gov (United States)

    Koh, Joyce H. L.; Divaharan, Shanti

    2011-01-01

    This study describes the TPACK-Developing Instructional Model which prescribes an instructional process for developing pre-service teachers' Technological Pedagogical Content Knowledge (TPACK) during the instruction of Information and Communication Technology (ICT) tools. This model proposes three phases for developing teachers' TPACK through ICT…

  9. An Instrument Development Model for Online Surveys in Human Resource Development and Adult Education

    Science.gov (United States)

    Strachota, Elaine M.; Conceicao, Simone C. O.; Schmidt, Steven W.

    2006-01-01

    This article describes the use of a schematic model for developing and distributing online surveys. Two empirical studies that developed and implemented online surveys to collect data to measure satisfaction in various aspects of human resource development and adult education exemplify the use of the model to conduct online survey research. The…

  10. Development and verification of printed circuit board toroidal transformer model

    DEFF Research Database (Denmark)

    Pejtersen, Jens; Mønster, Jakob Døllner; Knott, Arnold

    2013-01-01

    An analytical model of an air core printed circuit board embedded toroidal transformer configuration is presented. The transformer has been developed for galvanic isolation of very high frequency switch-mode dc-dc power converter applications. The theoretical model is developed and verified...... by comparing calculated parameters with 3D finite element simulations and experimental measurement results. The developed transformer model shows good agreement with the simulated and measured results. The model can be used to predict the parameters of printed circuit board toroidal transformer configurations...

  11. The Development of a Secondary School Health Assessment Model

    Science.gov (United States)

    Sriring, Srinual; Erawan, Prawit; Sriwarom, Monoon

    2015-01-01

    The objective of this research was to: 1) involved a survey of information relating to secondary school health, 2) involved the construction of a model of health assessment and a handbook for using the model in secondary school, 3) develop an assessment model for secondary school. The research included 3 phases. (1) involved a survey of…

  12. Design and Development Research: A Model Validation Case

    Science.gov (United States)

    Tracey, Monica W.

    2009-01-01

    This is a report of one case of a design and development research study that aimed to validate an overlay instructional design model incorporating the theory of multiple intelligences into instructional systems design. After design and expert review model validation, The Multiple Intelligence (MI) Design Model, used with an Instructional Systems…

  13. Development of a Model for Whole Brain Learning of Physiology

    Science.gov (United States)

    Eagleton, Saramarie; Muller, Anton

    2011-01-01

    In this report, a model was developed for whole brain learning based on Curry's onion model. Curry described the effect of personality traits as the inner layer of learning, information-processing styles as the middle layer of learning, and environmental and instructional preferences as the outer layer of learning. The model that was developed…

  14. A Dynamic Systems Theory Model of Visual Perception Development

    Science.gov (United States)

    Coté, Carol A.

    2015-01-01

    This article presents a model for understanding the development of visual perception from a dynamic systems theory perspective. It contrasts to a hierarchical or reductionist model that is often found in the occupational therapy literature. In this proposed model vision and ocular motor abilities are not foundational to perception, they are seen…

  15. Systems modelling and the development of coherent cell biological knowledge

    NARCIS (Netherlands)

    Verhoeff, R.; Waarlo, A.J.|info:eu-repo/dai/nl/074372246; Boersma, K.T.|info:eu-repo/dai/nl/073043141

    2008-01-01

    This article reports on educational design research concerning a learning and teaching strategy for cell biology in upper-secondary education introducing systems modelling as a key competence. The strategy consists of four modelling phases in which students subsequently develop models of freeliving

  16. Developing engineering processes through integrated modelling of product and process

    DEFF Research Database (Denmark)

    Nielsen, Jeppe Bjerrum; Hvam, Lars

    2012-01-01

    This article aims at developing an operational tool for integrated modelling of product assortments and engineering processes in companies making customer specific products. Integrating a product model in the design of engineering processes will provide a deeper understanding of the engineering...... activities as well as insight into how product features affect the engineering processes. The article suggests possible ways of integrating models of products with models of engineering processes. The models have been tested and further developed in an action research study carried out in collaboration...... with a major international engineering company....

  17. Internal migration in contemporary Nepal: models which internalize development policies.

    Science.gov (United States)

    Thapa, P; Conway, D

    1983-01-01

    "A set of models is developed to assess at the interdistrict level the relative importance of economic, demographic, social and government policy determinants of internal migration in Nepal. The first 'proximate' model and the second 'structural' model estimates are generated using ordinary least squares regression and specification error is investigated by spatial autocorrelation tests of the residuals of each model in its reduced form....Finally, to formalize and evaluate empirically the linkages between the 'proximate' and 'structural' determinants, a simultaneous equation model is developed using three stage generalized least squares regression." excerpt

  18. Integrating Design Decision Management with Model-based Software Development

    DEFF Research Database (Denmark)

    Könemann, Patrick

    Design decisions are continuously made during the development of software systems and are important artifacts for design documentation. Dedicated decision management systems are often used to capture such design knowledge. Most such systems are, however, separated from the design artifacts...... of the system. In model-based software development, where design models are used to develop a software system, outcomes of many design decisions have big impact on design models. The realization of design decisions is often manual and tedious work on design models. Moreover, keeping design models consistent...... to specify realizations of decisions in design models. This way, recurring realization work of design decisions can be automated. Since the concepts are generic and not bound to design decisions, other recurring work on models can be automated as well, for instance, design patterns and refactorings...

  19. Extending product modeling methods for integrated product development

    DEFF Research Database (Denmark)

    Bonev, Martin; Wörösch, Michael; Hauksdóttir, Dagný

    2013-01-01

    . Updated design requirements have then to be made explicit and mapped against the existing product architecture. In this paper, existing methods are adapted and extended through linking updated requirements to suitable product models. By combining several established modeling techniques, such as the DSM......Despite great efforts within the modeling domain, the majority of methods often address the uncommon design situation of an original product development. However, studies illustrate that development tasks are predominantly related to redesigning, improving, and extending already existing products...

  20. Proposal for product development model focused on ce certification methodology

    Directory of Open Access Journals (Sweden)

    Nathalia Marcia Goulart Pinheiro

    2015-09-01

    Full Text Available This paper presents a critical analysis comparing 21 product development models in order to identify whether these structures meet the demands Product Certification of the European Community (CE. Furthermore, it presents a product development model, comprising the steps in the models analyzed, including improvements in activities for referred product certification. The proposed improvements are justified by the growing quest for the internationalization of products and processes within companies.

  1. Cognitive components underpinning the development of model-based learning.

    Science.gov (United States)

    Potter, Tracey C S; Bryce, Nessa V; Hartley, Catherine A

    2017-06-01

    Reinforcement learning theory distinguishes "model-free" learning, which fosters reflexive repetition of previously rewarded actions, from "model-based" learning, which recruits a mental model of the environment to flexibly select goal-directed actions. Whereas model-free learning is evident across development, recruitment of model-based learning appears to increase with age. However, the cognitive processes underlying the development of model-based learning remain poorly characterized. Here, we examined whether age-related differences in cognitive processes underlying the construction and flexible recruitment of mental models predict developmental increases in model-based choice. In a cohort of participants aged 9-25, we examined whether the abilities to infer sequential regularities in the environment ("statistical learning"), maintain information in an active state ("working memory") and integrate distant concepts to solve problems ("fluid reasoning") predicted age-related improvements in model-based choice. We found that age-related improvements in statistical learning performance did not mediate the relationship between age and model-based choice. Ceiling performance on our working memory assay prevented examination of its contribution to model-based learning. However, age-related improvements in fluid reasoning statistically mediated the developmental increase in the recruitment of a model-based strategy. These findings suggest that gradual development of fluid reasoning may be a critical component process underlying the emergence of model-based learning. Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.

  2. Development and evaluation of thermal model reduction algorithms for spacecraft

    Science.gov (United States)

    Deiml, Michael; Suderland, Martin; Reiss, Philipp; Czupalla, Markus

    2015-05-01

    This paper is concerned with the topic of the reduction of thermal models of spacecraft. The work presented here has been conducted in cooperation with the company OHB AG, formerly Kayser-Threde GmbH, and the Institute of Astronautics at Technische Universität München with the goal to shorten and automatize the time-consuming and manual process of thermal model reduction. The reduction of thermal models can be divided into the simplification of the geometry model for calculation of external heat flows and radiative couplings and into the reduction of the underlying mathematical model. For simplification a method has been developed which approximates the reduced geometry model with the help of an optimization algorithm. Different linear and nonlinear model reduction techniques have been evaluated for their applicability in reduction of the mathematical model. Thereby the compatibility with the thermal analysis tool ESATAN-TMS is of major concern, which restricts the useful application of these methods. Additional model reduction methods have been developed, which account to these constraints. The Matrix Reduction method allows the approximation of the differential equation to reference values exactly expect for numerical errors. The summation method enables a useful, applicable reduction of thermal models that can be used in industry. In this work a framework for model reduction of thermal models has been created, which can be used together with a newly developed graphical user interface for the reduction of thermal models in industry.

  3. Performance of fire behavior fuel models developed for the Rothermel Surface Fire Spread Model

    Science.gov (United States)

    Robert Ziel; W. Matt Jolly

    2009-01-01

    In 2005, 40 new fire behavior fuel models were published for use with the Rothermel Surface Fire Spread Model. These new models are intended to augment the original 13 developed in 1972 and 1976. As a compiled set of quantitative fuel descriptions that serve as input to the Rothermel model, the selected fire behavior fuel model has always been critical to the resulting...

  4. Investigating the Relationship between Students' Views of Scientific Models and Their Development of Models

    Science.gov (United States)

    Cheng, Meng-Fei; Lin, Jang-Long

    2015-01-01

    Understanding the nature of models and engaging in modeling practice have been emphasized in science education. However, few studies discuss the relationships between students' views of scientific models and their ability to develop those models. Hence, this study explores the relationship between students' views of scientific models and their…

  5. The Importance of Animal Models in Tuberculosis Vaccine Development

    OpenAIRE

    Acosta, Armando; Norazmi, Mohd Nor; Hernandez-Pando, Rogelio; Alvarez, Nadine; Borrero, Reinier; Infante, Juan F; Sarmiento, Maria E

    2011-01-01

    Research, development, and production of vaccines are still highly dependent on the use of animal models in the various evaluation steps. Despite this fact, there are strong interests and ongoing efforts to reduce the use of animals in vaccine development. Tuberculosis vaccine development is one important example of the complexities involved in the use of animal models for the production of new vaccines. This review summarises some of the general aspects related with the use of animals in vac...

  6. International Jobs and Economic Development Impacts (I-JEDI) Model

    Energy Technology Data Exchange (ETDEWEB)

    2016-09-01

    International Jobs and Economic Development Impacts (I-JEDI) is a freely available economic model that estimates gross economic impacts from wind, solar, biomass, and geothermal energy projects. Building on a similar model for the United States, I-JEDI was developed by the National Renewable Energy Laboratory under the U.S. government's Enhancing Capacity for Low Emission Development Strategies (EC-LEDS) program to support partner countries in assessing economic impacts of LEDS actions in the energy sector.

  7. Embedded systems development from functional models to implementations

    CERN Document Server

    Zeng, Haibo; Natale, Marco; Marwedel, Peter

    2014-01-01

    This book offers readers broad coverage of techniques to model, verify and validate the behavior and performance of complex distributed embedded systems.  The authors attempt to bridge the gap between the three disciplines of model-based design, real-time analysis and model-driven development, for a better understanding of the ways in which new development flows can be constructed, going from system-level modeling to the correct and predictable generation of a distributed implementation, leveraging current and future research results.     Describes integration of heterogeneous models; Discusses synthesis of task model implementations and code implementations; Compares model-based design vs. model-driven approaches; Explains how to enforce correctness by construction in the functional and time domains; Includes optimization techniques for control performance.

  8. Development of Models for Regional Cardiac Surgery Centers

    Directory of Open Access Journals (Sweden)

    Choon Seon Park

    2016-12-01

    Full Text Available Background: This study aimed to develop the models for regional cardiac surgery centers, which take regional characteristics into consideration, as a policy measure that could alleviate the concentration of cardiac surgery in the metropolitan area and enhance the accessibility for patients who reside in the regions. Methods: To develop the models and set standards for the necessary personnel and facilities for the initial management plan, we held workshops, debates, and conference meetings with various experts. Results: After partitioning the plan into two parts (the operational autonomy and the functional comprehensiveness, three models were developed: the ‘independent regional cardiac surgery center’ model, the ‘satellite cardiac surgery center within hospitals’ model, and the ‘extended cardiac surgery department within hospitals’ model. Proposals on personnel and facility management for each of the models were also presented. A regional cardiac surgery center model that could be applied to each treatment area was proposed, which was developed based on the anticipated demand for cardiac surgery. The independent model or the satellite model was proposed for Chungcheong, Jeolla, North Gyeongsang, and South Gyeongsang area, where more than 500 cardiac surgeries are performed annually. The extended model was proposed as most effective for the Gangwon and Jeju area, where more than 200 cardiac surgeries are performed annually. Conclusion: The operation of regional cardiac surgery centers with high caliber professionals and quality resources such as optimal equipment and facility size, should enhance regional healthcare accessibility and the quality of cardiac surgery in South Korea.

  9. Development of new model for high explosives detonation parameters calculation

    Directory of Open Access Journals (Sweden)

    Jeremić Radun

    2012-01-01

    Full Text Available The simple semi-empirical model for calculation of detonation pressure and velocity for CHNO explosives has been developed, which is based on experimental values of detonation parameters. Model uses Avakyan’s method for determination of detonation products' chemical composition, and is applicable in wide range of densities. Compared with the well-known Kamlet's method and numerical model of detonation based on BKW EOS, the calculated values from proposed model have significantly better accuracy.

  10. The Development Model Electronic Commerce of Regional Agriculture

    Science.gov (United States)

    Kang, Jun; Cai, Lecai; Li, Hongchan

    With the developing of the agricultural information, it is inevitable trend of the development of agricultural electronic commercial affairs. On the basis of existing study on the development application model of e-commerce, combined with the character of the agricultural information, compared with the developing model from the theory and reality, a new development model electronic commerce of regional agriculture base on the government is put up, and such key issues as problems of the security applications, payment mode, sharing mechanisms, and legal protection are analyzed, etc. The among coordination mechanism of the region is discussed on, it is significance for regulating the development of agricultural e-commerce and promoting the regional economical development.

  11. Models of latent tuberculosis: Their salient features, limitations, and development

    Directory of Open Access Journals (Sweden)

    Kamlesh Patel

    2011-01-01

    Full Text Available Latent tuberculosis is a subclinical condition caused by Mycobacterium tuberculosis, which affects about one-third of the population across the world. To abridge the chemotherapy of tuberculosis, it is necessary to have active drugs against latent form of M. tuberculosis. Therefore, it is imperative to devise in vitro and models of latent tuberculosis to explore potential drugs. In vitro models such as hypoxia, nutrient starvation, and multiple stresses are based on adverse conditions encountered by bacilli in granuloma. Bacilli experience oxygen depletion condition in hypoxia model, whereas the nutrient starvation model is based on deprivation of total nutrients from a culture medium. In the multiple stress model dormancy is induced by more than one type of stress. In silico mathematical models have also been developed to predict the interactions of bacilli with the host immune system and to propose structures for potential anti tuberculosis compounds. Besides these in vitro and in silico models, there are a number of in vivo animal models like mouse, guinea pig, rabbit, etc. Although they simulate human latent tuberculosis up to a certain extent but do not truly replicate human infection. All these models have their inherent merits and demerits. However, there is no perfect model for latent tuberculosis. Therefore, it is imperative to upgrade and refine existing models or develop a new model. However, battery of models will always be a better alternative to any single model as they will complement each other by overcoming their limitations.

  12. Models of Latent Tuberculosis: Their Salient Features, Limitations, and Development

    Science.gov (United States)

    Patel, Kamlesh; Jhamb, Sarbjit Singh; Singh, Prati Pal

    2011-01-01

    Latent tuberculosis is a subclinical condition caused by Mycobacterium tuberculosis, which affects about one-third of the population across the world. To abridge the chemotherapy of tuberculosis, it is necessary to have active drugs against latent form of M. tuberculosis. Therefore, it is imperative to devise in vitro and models of latent tuberculosis to explore potential drugs. In vitro models such as hypoxia, nutrient starvation, and multiple stresses are based on adverse conditions encountered by bacilli in granuloma. Bacilli experience oxygen depletion condition in hypoxia model, whereas the nutrient starvation model is based on deprivation of total nutrients from a culture medium. In the multiple stress model dormancy is induced by more than one type of stress. In silico mathematical models have also been developed to predict the interactions of bacilli with the host immune system and to propose structures for potential anti tuberculosis compounds. Besides these in vitro and in silico models, there are a number of in vivo animal models like mouse, guinea pig, rabbit, etc. Although they simulate human latent tuberculosis up to a certain extent but do not truly replicate human infection. All these models have their inherent merits and demerits. However, there is no perfect model for latent tuberculosis. Therefore, it is imperative to upgrade and refine existing models or develop a new model. However, battery of models will always be a better alternative to any single model as they will complement each other by overcoming their limitations. PMID:22219558

  13. IDEF method-based simulation model design and development framework

    Directory of Open Access Journals (Sweden)

    Ki-Young Jeong

    2009-09-01

    Full Text Available The purpose of this study is to provide an IDEF method-based integrated framework for a business process simulation model to reduce the model development time by increasing the communication and knowledge reusability during a simulation project. In this framework, simulation requirements are collected by a function modeling method (IDEF0 and a process modeling method (IDEF3. Based on these requirements, a common data model is constructed using the IDEF1X method. From this reusable data model, multiple simulation models are automatically generated using a database-driven simulation model development approach. The framework is claimed to help both requirement collection and experimentation phases during a simulation project by improving system knowledge, model reusability, and maintainability through the systematic use of three descriptive IDEF methods and the features of the relational database technologies. A complex semiconductor fabrication case study was used as a testbed to evaluate and illustrate the concepts and the framework. Two different simulation software products were used to develop and control the semiconductor model from the same knowledge base. The case study empirically showed that this framework could help improve the simulation project processes by using IDEF-based descriptive models and the relational database technology. Authors also concluded that this framework could be easily applied to other analytical model generation by separating the logic from the data.

  14. An evaluation of the Contractor Development Model of Working for ...

    African Journals Online (AJOL)

    However, it also has a social development component, which aims at the promotion of small business and entrepreneurship development. This paper explores the socio-economic rationale of one component, the Contractor Development Model. It does so via an examination of the programme's assumptions, and the ...

  15. Toward a Model of Vocational Development of People with Disabilities.

    Science.gov (United States)

    Goldberg, Richard T.

    1992-01-01

    Focusing on people with disabilities, evaluates vocational development theories, evaluates relevant research, describes scale of vocational development, and suggests model of vocational development. Review of studies suggests that people with acquired disabilities tended to choose occupations consistent with predisability plans, while people with…

  16. A Teacher Professional Development Model for Teaching Socioscientific Issues

    Science.gov (United States)

    Carson, Katherine; Dawson, Vaille

    2016-01-01

    This paper describes the development and implementation of a three-pillared model for teaching socioscientific issues: teacher professional development; curriculum resources; and classroom support. A professional development program and curriculum resource based on the socioscientific issue of climate change was trialled with 75 Western Australian…

  17. Industrialized Development Models of Agricultural Scientific and Technological Achievements

    OpenAIRE

    WANG, Wanjiang

    2015-01-01

    Industrialization of agricultural scientific and technological achievements has become an extremely important part in agricultural structural adjustment and agricultural economic development. Basic models for industrialization of China’s agricultural scientific and technological achievements should be: (i) integrating scientific and technological development and production relying on large enterprises; (ii) integrating scientific research and development with agricultural scientific and tec...

  18. Construction of UML class diagram with Model-Driven Development

    Directory of Open Access Journals (Sweden)

    Tomasz Górski

    2016-03-01

    Full Text Available Model transformations play a key role in software development projects based on Model--Driven Development (MDD principles. Transformations allow for automation of repetitive and well-defined steps, thus shortening design time and reducing a number of errors. In the object-oriented approach, the key elements are use cases. They are described, modelled and later designed until executable application code is obtained. The aim of the paper is to present transformation of a model-to-model type, Communication-2-Class, which automates construction of Unified Modelling Language (UML class diagram in the context of the analysis/design model. An UML class diagram is created based on UML communication diagram within use case realization. As a result, a class diagram shows all of the classes involved in the use case realization and the relationships among them. The plug-in which implements Communication-2-Class transformation was implemented in the IBM Rational Software Architect. The article presents the tests results of developed plug-in, which realizes Communication-2-Class transformation, showing capabilities of shortening use case realization’s design time.[b]Keywords[/b]: Model-Driven Development, transformations, Unified Modelling Language, analysis/design model, UML class diagram, UML communication diagram

  19. A Product Development Decision Model for Cockpit Weather Information Systems

    Science.gov (United States)

    Sireli, Yesim; Kauffmann, Paul; Gupta, Surabhi; Kachroo, Pushkin

    2003-01-01

    There is a significant market demand for advanced cockpit weather information products. However, it is unclear how to identify the most promising technological options that provide the desired mix of consumer requirements by employing feasible technical systems at a price that achieves market success. This study develops a unique product development decision model that employs Quality Function Deployment (QFD) and Kano's model of consumer choice. This model is specifically designed for exploration and resolution of this and similar information technology related product development problems.

  20. A Product Development Decision Model for Cockpit Weather Information System

    Science.gov (United States)

    Sireli, Yesim; Kauffmann, Paul; Gupta, Surabhi; Kachroo, Pushkin; Johnson, Edward J., Jr. (Technical Monitor)

    2003-01-01

    There is a significant market demand for advanced cockpit weather information products. However, it is unclear how to identify the most promising technological options that provide the desired mix of consumer requirements by employing feasible technical systems at a price that achieves market success. This study develops a unique product development decision model that employs Quality Function Deployment (QFD) and Kano's model of consumer choice. This model is specifically designed for exploration and resolution of this and similar information technology related product development problems.

  1. Modelling continuing professional development in an innovative context

    DEFF Research Database (Denmark)

    Fink, Flemming K.

    2001-01-01

    subject to very fast innovation processes. Continuing Professional Development of engineering staff is therefore very important. A model for the continuing education process will be described. The elements of the model and their interaction will be discussed. Part of the modelling is based on interviews......Being one step ahead of your competitors with incorporation of new knowledge in the products puts focus on the importance of human resources as a significant resource for industrial development. A major competitive parameter in knowledge society is engineering competence, especially in the industry...... with development engineers from the very dynamic mobile communication industry. Some examples of CPD-programmes will be described....

  2. The Guided System Development Framework: Modeling and Verifying Communication Systems

    DEFF Research Database (Denmark)

    Carvalho Quaresma, Jose Nuno; Probst, Christian W.; Nielson, Flemming

    2014-01-01

    . The Guided System Development framework contributes to more secure communication systems by aiding the development of such systems. The framework features a simple modelling language, step-wise refinement from models to implementation, interfaces to security verification tools, and code generation from...... the verified specification. The refinement process carries thus security properties from the model to the implementation. Our approach also supports verification of systems previously developed and deployed. Internally, the reasoning in our framework is based on the Beliefs and Knowledge tool, a verification...

  3. Template and Model Driven Development of Standardized Electronic Health Records.

    Science.gov (United States)

    Kropf, Stefan; Chalopin, Claire; Denecke, Kerstin

    2015-01-01

    Digital patient modeling targets the integration of distributed patient data into one overarching model. For this integration process, both a theoretical standard-based model and information structures combined with concrete instructions in form of a lightweight development process of single standardized Electronic Health Records (EHRs) are needed. In this paper, we introduce such a process along side a standard-based architecture. It allows the modeling and implementation of EHRs in a lightweight Electronic Health Record System (EHRS) core. The approach is demonstrated and tested by a prototype implementation. The results show that the suggested approach is useful and facilitates the development of standardized EHRSs.

  4. Wake models developed during the Wind Shadow Project

    DEFF Research Database (Denmark)

    Larsen, Søren Ejling; Ott, Søren; Pena Diaz, Alfredo

    The Wind Shadow project has developed and validated improved models for determining the wakes losses, and thereby the array efficiency of very large, closely packed wind farms. The rationale behind the project has been that the existing software has been covering these types of wind farms poorly......, both with respect to the densely packed turbines and the large fetches needed to describe the collective shadow effects of one farm to the next. Further the project has developed the necessary software for the use of the models. Guidelines with recommendations for the use of the models are included...... in the model deliverables....

  5. Evolutionary Development of the Simulation by Logical Modeling System (SIBYL)

    Science.gov (United States)

    Wu, Helen

    1995-01-01

    Through the evolutionary development of the Simulation by Logical Modeling System (SIBYL) we have re-engineered the expensive and complex IBM mainframe based Long-term Hardware Projection Model (LHPM) to a robust cost-effective computer based mode that is easy to use. We achieved significant cost reductions and improved productivity in preparing long-term forecasts of Space Shuttle Main Engine (SSME) hardware. The LHPM for the SSME is a stochastic simulation model that projects the hardware requirements over 10 years. SIBYL is now the primary modeling tool for developing SSME logistics proposals and Program Operating Plan (POP) for NASA and divisional marketing studies.

  6. Scripting MODFLOW model development using Python and FloPy

    Science.gov (United States)

    Bakker, Mark; Post, Vincent E. A.; Langevin, Christian D.; Hughes, Joseph D.; White, Jeremy; Starn, Jeffrey; Fienen, Michael N.

    2016-01-01

    Graphical user interfaces (GUIs) are commonly used to construct and postprocess numerical groundwater flow and transport models. Scripting model development with the programming language Python is presented here as an alternative approach. One advantage of Python is that there are many packages available to facilitate the model development process, including packages for plotting, array manipulation, optimization, and data analysis. For MODFLOW-based models, the FloPy package was developed by the authors to construct model input files, run the model, and read and plot simulation results. Use of Python with the available scientific packages and FloPy facilitates data exploration, alternative model evaluations, and model analyses that can be difficult to perform with GUIs. Furthermore, Python scripts are a complete, transparent, and repeatable record of the modeling process. The approach is introduced with a simple FloPy example to create and postprocess a MODFLOW model. A more complicated capture-fraction analysis with a real-world model is presented to demonstrate the types of analyses that can be performed using Python and FloPy.

  7. The Cluster Model of Development of the City

    Directory of Open Access Journals (Sweden)

    Panfilov Aleksandr

    2016-01-01

    Full Text Available The article deals with issues related to the current state and development of the concept of urban development and urban analysis, whose main task is to develop an evolutionary model settlements development. However, urban science covers many related areas of knowledge, and is becoming one of the areas of fundamental research on the theory of the development of society as a whole. It is in urban planning are reflected culture, sociology, economics, politics and much more, giving to Tectological characteristics. At the same mechanics of their interactions allows us to look at the city as a system matrix structures, interacting in time and space, and have the features of the cluster and fractal models. Cited in the article description of the author’s concept of cluster model of development of the city raises fundamental questions about its formation, determines the key parameters and mechanisms for its operation.

  8. Modelling architectures in multi-product oriented technology development

    DEFF Research Database (Denmark)

    Guðlaugsson, Tómas Vignir

    and breakdown of product technologies based on a generic product technology architecture as organs and organ alternatives and links these through product concepts to application concepts and requirements.The Production Architecture modelling framework enables modelling a Production Architecture from three......This thesis investigates the use of architecture modelling in a technology development context.This context presents greater uncertainties than more mature new product development. Applications—the use of products based on the technology being developed—are not fully identified and the requirements...... to be fulfilled are not completely defined.The products to be based on the technology are yet to be developed as the foundation for their development will be developed during the technology development. Furthermore, the production of a new technology is not defined as both the technology and derivative products...

  9. Model development for auralization of interior tyre noise

    OpenAIRE

    Löfdahl, Magnus

    2011-01-01

    Increasing competition has set pressure on the product development process to reduce development time and costs. Computer Aided Engineering (CAE) has been used to decrease development times by facilitating early predictions of product performances and qualities. Especially in early phases of product development, models with sufficient accuracy can provide valuable decision supports in order to pass legislations and fulfill customer expectations. Acoustic performance and sound quality are esse...

  10. Plasma Modeling Enabled Technology Development Empowered by Fundamental Scattering Data

    Science.gov (United States)

    Kushner, Mark J.

    2016-05-01

    Technology development increasingly relies on modeling to speed the innovation cycle. This is particularly true for systems using low temperature plasmas (LTPs) and their role in enabling energy efficient processes with minimal environmental impact. In the innovation cycle, LTP modeling supports investigation of fundamental processes that seed the cycle, optimization of newly developed technologies, and prediction of performance of unbuilt systems for new applications. Although proof-of-principle modeling may be performed for idealized systems in simple gases, technology development must address physically complex systems that use complex gas mixtures that now may be multi-phase (e.g., in contact with liquids). The variety of fundamental electron and ion scattering, and radiation transport data (FSRD) required for this modeling increases as the innovation cycle progresses, while the accuracy required of that data depends on the intended outcome. In all cases, the fidelity, depth and impact of the modeling depends on the availability of FSRD. Modeling and technology development are, in fact, empowered by the availability and robustness of FSRD. In this talk, examples of the impact of and requirements for FSRD in the innovation cycle enabled by plasma modeling will be discussed using results from multidimensional and global models. Examples of fundamental studies and technology optimization will focus on microelectronics fabrication and on optically pumped lasers. Modeling of systems as yet unbuilt will address the interaction of atmospheric pressure plasmas with liquids. Work supported by DOE Office of Fusion Energy Science and the National Science Foundation.

  11. Features of Balance Model Development of Exclave Region

    Directory of Open Access Journals (Sweden)

    Timur Rustamovich Gareev

    2015-06-01

    Full Text Available In the article, the authors build a balance model for an exclave region. The aim of the work is to explore the unique properties of exclaves to evaluate the possibility of development of a more complex model for the economy of a region. Exclaves are strange phenomena in both theoretical and practical regional economy. There is lack of comparative models, so it is typically quite challenging to study exclaves. At the same time, exclaves produce better statistics, which gives more careful consideration of cross-regional economic flows. The authors discuss methodologies of model-based regional development forecasting. They analyze balance approach on a more general level of regional governance and individually, on the example of specific territories. Thus, they identify and explain the need to develop balance approach models fitted to the special needs of certain territories. By combining regional modeling for an exclave with traditional balance and simulation-based methods and event-based approach, they come up with a more detailed model for the economy of a region. Having taken one Russian exclave as an example, the authors have developed a simulation event-based long-term sustainability model. In the article, they provide the general characteristics of the model, describe its components, and simulation algorithm. The approach introduced in this article combines the traditional balance models and the peculiarities of an exclave region to develop a holistic regional economy model (with the Kaliningrad region serving as an example. It is important to underline that the resulting model helps to evaluate the degree of influence of preferential economic regimes (such as Free Customs Zone, for example on the economy of a region.

  12. A Study On Traditional And Evolutionary Software Development Models

    Directory of Open Access Journals (Sweden)

    Kamran Rasheed

    2017-07-01

    Full Text Available Today Computing technologies are becoming the pioneers of the organizations and helpful in individual functionality i.e. added to computing device we need to add softwares. Set of instruction or computer program is known as software. The development of software is done through some traditional or some new or evolutionary models. Software development is becoming a key and a successful business nowadays. Without software all hardware is useless. Some collective steps that are performed in the development of these are known as Software development life cycle SDLC. There are some adaptive and predictive models for developing software. Predictive mean already known like WATERFALL Spiral Prototype and V-shaped models while Adaptive model include agile Scrum. All methodologies of both adaptive and predictive have their own procedure and steps. Predictive are Static and Adaptive are dynamic mean change cannot be made to the predictive while adaptive have the capability of changing. The purpose of this study is to get familiar with all these and discuss their uses and steps of development. This discussion will be helpful in deciding which model they should use in which circumstance and what are the development step including in each model.

  13. Development of Knowledge Management Model for Developing the Internal Quality Assurance in Educational Opportunity Expansion Schools

    Science.gov (United States)

    Pradabpech, Pipat; Chantarasombat, Chalard; Sriampai, Anan

    2015-01-01

    This research for: 1) to study the current situation and problem in KM, 2) to develop the KM Model, and 3) to evaluate the finding usage of the KM Model for developing the Internal Quality Assurance of Educational Opportunity Expansion Schools. There were 3 Phases of research implementation. Phase 1: the current situation and problem in KM, was…

  14. Developing an Organizational Commitment to Employee Success: The Student Affairs Staff Development Model.

    Science.gov (United States)

    Burke, Thomas H.; Randall, Kathleen P.

    1994-01-01

    Presents unique model of staff development for student affairs division based on current strategies which have proven to be successful in corporate sector. Notes that model has twofold purpose of addressing concerns regarding opportunities for professional development and problem of institutional staff attrition in field of student affairs.…

  15. Agent Model Development for Assessing Climate-Induced Geopolitical Instability.

    Energy Technology Data Exchange (ETDEWEB)

    Boslough, Mark B.; Backus, George A.

    2005-12-01

    We present the initial stages of development of new agent-based computational methods to generate and test hypotheses about linkages between environmental change and international instability. This report summarizes the first year's effort of an originally proposed three-year Laboratory Directed Research and Development (LDRD) project. The preliminary work focused on a set of simple agent-based models and benefited from lessons learned in previous related projects and case studies of human response to climate change and environmental scarcity. Our approach was to define a qualitative model using extremely simple cellular agent models akin to Lovelock's Daisyworld and Schelling's segregation model. Such models do not require significant computing resources, and users can modify behavior rules to gain insights. One of the difficulties in agent-based modeling is finding the right balance between model simplicity and real-world representation. Our approach was to keep agent behaviors as simple as possible during the development stage (described herein) and to ground them with a realistic geospatial Earth system model in subsequent years. This work is directed toward incorporating projected climate data--including various C02 scenarios from the Intergovernmental Panel on Climate Change (IPCC) Third Assessment Report--and ultimately toward coupling a useful agent-based model to a general circulation model.3

  16. Development of in silico models for human liver microsomal stability

    Science.gov (United States)

    Lee, Pil H.; Cucurull-Sanchez, Lourdes; Lu, Jing; Du, Yuhua J.

    2007-12-01

    We developed highly predictive classification models for human liver microsomal (HLM) stability using the apparent intrinsic clearance (CLint, app) as the end point. HLM stability has been shown to be an important factor related to the metabolic clearance of a compound. Robust in silico models that predict metabolic clearance are very useful in early drug discovery stages to optimize the compound structure and to select promising leads to avoid costly drug development failures in later stages. Using Random Forest and Bayesian classification methods with MOE, E-state descriptors, ADME Keys, and ECFP_6 fingerprints, various highly predictive models were developed. The best performance of the models shows 80 and 75% prediction accuracy for the test and validation sets, respectively. A detailed analysis of results will be shown, including an assessment of the prediction confidence, the significant descriptors, and the application of these models to drug discovery projects.

  17. Hydrogeological conceptual model development and numerical modelling using CONNECTFLOW, Forsmark modelling stage 2.3

    Energy Technology Data Exchange (ETDEWEB)

    Follin, Sven (SF GeoLogic AB, Taeby (Sweden)); Hartley, Lee; Jackson, Peter; Roberts, David (Serco TAP (United Kingdom)); Marsic, Niko (Kemakta Konsult AB, Stockholm (Sweden))

    2008-05-15

    of spatial variability of the hydraulic properties within soil layers and horizontal versus vertical anisotropy in the hydraulic conductivity of soils. For the deformation zones, the same prescription for assigning transmissivities was followed as for stage 2.2, but a new method for automating the local conditioning of the deformation zone transmissivity in the vicinity of a measurement interval was used. The numerical simulations carried out in stage 2.2 demonstrated that the three geological units: deformation zones, fracture domains and regolith, can be parameterised by means of single-hole hydraulic tests and satisfactorily transformed into heterogeneous hydraulic conductor domains (HCD), hydraulic rock mass domains (HRD) and hydraulic soil domains (HSD). This means that the conceptual model developed from the interpretation of Forsmark data in stage 2.2 can be used to predict a wide range of different types of data and processes such as 1) large-scale cross-hole test responses, 2) natural point-water heads in the bedrock and the regolith, and 3) hydrochemistry profiles along the many cored boreholes drilled in close proximity to the so called target area. It is noted that a primary idea of the confirmatory testing applied in stage 2.2 is that the same groundwater flow and solute transport model is used for each type of simulation to make it transparent that a single implementation of the conceptual model could be calibrated against all three types of field observations, although it may have been possible to improve the modelling of a particular data type by refining the model around a relevant observation borehole, for example. The conceptual modelling in stage 2.2 invoked a number of hypotheses, three of which that were addressed in stage 2.3 by means of complementary field investigations (hydraulic tests). The results from these investigations do not falsify (contradict) any of the three hypotheses, hence none of them should be rejected. In fact, the three

  18. Developing a Model for Sustainable Hotels in Northern Cyprus

    National Research Council Canada - National Science Library

    Soad Abokhamis Mousavi; Ercan Hoşkara; Kyle M Woosnam

    2017-01-01

    The purpose of this work is to develop a sustainable hotel building model (SHBM) that will allow for the measurement of sustainability in determining what conditions are most ideal for hotels in Northern Cyprus...

  19. Use of Model Payload for Europa Mission Development

    Science.gov (United States)

    Lewis, Kari; Klaasan, Ken; Susca, Sara; Oaida, Bogdan; Larson, Melora; Vanelli, Tony; Murray, Alex; Jones, Laura; Thomas, Valerie; Frank, Larry

    2016-01-01

    This paper discusses the basis for the Model Payload and how it was used to develop the mission design, observation and data acquisition strategy, needed spacecraft capabilities, spacecraft-payload interface needs, mission system requirements and operational scenarios.

  20. Development of a Generic Didactic Model for Simulator Training

    National Research Council Canada - National Science Library

    Emmerik, M

    1997-01-01

    .... The development of such a model is motivated by the need to control training and instruction factors in research on simulator fidelity, the need to assess the benefit of training simulators, e.g...

  1. Development of Gene Centric Modeling for Nutrient Cycling

    Science.gov (United States)

    opportunity to participate in the development of a gene-centric model to help predict potential changes in the biogeochemistry of aquatic ecosystems that may arise from anthropogenic stressors and management decisions

  2. Development of a modular framework for computational modelling approaches

    OpenAIRE

    Petrović, Aleksandar

    2013-01-01

    Number of computational tools of mathematical models allow simulations of performance and analysis of the established models of biological systems in the field of synthetic and systems biology are already in place. The biggest drawback of the existing tools is the lack of modularity. The main objective of the thesis is to develop a modular framework that will enable development and integration of various building blocks mainly for synthetic and systems biology, and to enable future users and ...

  3. Clinical Strategies and Animal Models for Developing Senolytic Agents

    OpenAIRE

    Kirkland, James L.; Tchkonia, Tamara

    2014-01-01

    Aging is associated with increasing predisposition to multiple chronic diseases. One fundamental aging process that is often operative at sites of the pathology underlying chronic age-related diseases is cellular senescence. Small molecule senolytic agents are being developed. For successful drug development: 1) appropriate animal models of human age-related diseases need to be devised. 2) Models have to be made in which it can be proven that beneficial phenotypic effects are actually caused ...

  4. GEOCHEMICAL TESTING AND MODEL DEVELOPMENT - RESIDUAL TANK WASTE TEST PLAN

    Energy Technology Data Exchange (ETDEWEB)

    CANTRELL KJ; CONNELLY MP

    2010-03-09

    This Test Plan describes the testing and chemical analyses release rate studies on tank residual samples collected following the retrieval of waste from the tank. This work will provide the data required to develop a contaminant release model for the tank residuals from both sludge and salt cake single-shell tanks. The data are intended for use in the long-term performance assessment and conceptual model development.

  5. Development of a Water Recovery System Resource Tracking Model

    Science.gov (United States)

    Chambliss, Joe; Stambaugh, Imelda; Sargusingh, Miriam; Shull, Sarah; Moore, Michael

    2015-01-01

    A simulation model has been developed to track water resources in an exploration vehicle using Regenerative Life Support (RLS) systems. The Resource Tracking Model (RTM) integrates the functions of all the vehicle components that affect the processing and recovery of water during simulated missions. The approach used in developing the RTM enables its use as part of a complete vehicle simulation for real time mission studies. Performance data for the components in the RTM is focused on water processing. The data provided to the model has been based on the most recent information available regarding the technology of the component. This paper will describe the process of defining the RLS system to be modeled, the way the modeling environment was selected, and how the model has been implemented. Results showing how the RLS components exchange water are provided in a set of test cases.

  6. Further Development of the PCRTM Model and RT Model Inter Comparison

    Science.gov (United States)

    Yang, Qiguang; Liu, Xu; Wu, Wan; Kizer, Susan

    2015-01-01

    New results for the development of the PCRTM model will be presented. The new results were used for IASI retrieval validation inter comparison and better results were obtained compare to other fast radiative transfer models.

  7. Developing models for cachexia and their implications in drug discovery.

    Science.gov (United States)

    Konishi, Masaaki; Ebner, Nicole; von Haehling, Stephan; Anker, Stefan D; Springer, Jochen

    2015-07-01

    Cachexia is a complex metabolic syndrome associated with underlying illness and characterized by loss of muscle with or without loss of fat mass. Systemic inflammation plays a central role in its pathophysiology. As millions of patients are in a cachectic state of chronic disease, cachexia is one of the major causes of death worldwide. Difficulties in the recruitment and follow-up of clinical trials mean that well-characterized animal models are of great importance in developing cachexia therapies. However, some of the widely used animal models have limitations in procedural reproducibility or in recapitulating in the cachectic phenotype, which has warranted the development of novel models for cachexia. This review focuses on some of the currently developing rodent models designed to mimic each co-morbidity in cachexia. Through developing cancer models, researchers have been seeking more targets for intervention. In cardiac cachexia, technical issues have been overcome by transgenic models. Furthermore, the development of new animal models has enabled the elucidation of the roles of inflammation, anabolism/catabolism in muscle/fat tissue and anorexia on cachexia. As metabolic and inflammatory pathways in cachexia may compromise cardiac muscle, the analysis of cardiac function/tissue in non-cardiac cachexia may be a useful component of cachexia assessment common to different underlying diseases and pave the way for novel drug discovery.

  8. Development management model of elite athletes in team sports games.

    Science.gov (United States)

    Trninić, Marko; Trninić, Slavko; Papić, Vladan

    2009-06-01

    The scientific and expert approach to defining a model of managing the development of top-level athletes in team sports games is oriented toward the challenging values that mark a certain position and role in a team sports game. A hypothetical dynamic model of development management of top-level athletes in team sports games, which explicitly shows the order of procedures in the process of multidimensional development of athletes using the concepts of the dynamic systems theory has been suggested. The hypothetical model of management shows that the athlete's development is primarily under the influence of genetic potential, sports preparation process and the competition format, as well as the management of their lifestyle. In the process, the athlete's development is seen as a dynamic and plastic process under the influence of selective procedures and training programs that enable a continuous change in the level of the athlete's performance and sports preparation process.

  9. Developing an Interdisciplinary Curriculum Framework for Aquatic-Ecosystem Modeling

    Science.gov (United States)

    Saito, Laurel; Segale, Heather M.; DeAngelis, Donald L.; Jenkins, Stephen H.

    2007-01-01

    This paper presents results from a July 2005 workshop and course aimed at developing an interdisciplinary course on modeling aquatic ecosystems that will provide the next generation of practitioners with critical skills for which formal training is presently lacking. Five different course models were evaluated: (1) fundamentals/general principles…

  10. Development of rainfall-runoff forecast model | Oyebode | Journal of ...

    African Journals Online (AJOL)

    This study developed a neurofuzzy-based rainfall-runoff forecast model for river basin and evaluated the performance of the model. This was with a view to capturing the behaviour of hydrological and meterological variables involved in rainfall-runoff process to improve forecast accuracy of rainfallrunoff. Three hydrological ...

  11. Benchmark Dose Software Development and Maintenance Ten Berge Cxt Models

    Science.gov (United States)

    This report is intended to provide an overview of beta version 1.0 of the implementation of a concentration-time (CxT) model originally programmed and provided by Wil ten Berge (referred to hereafter as the ten Berge model). The recoding and development described here represent ...

  12. Improving Intercultural Competence in the Classroom: A Reflective Development Model

    Science.gov (United States)

    Feng, Jing Betty

    2016-01-01

    To meet the increased demand for international business education that prepares college students for studying, living, or working overseas, I propose a four-stage reflective development model to be used in the traditional classroom context to enhance intercultural competence for undergraduate students. I employ the model in a personal development…

  13. Modelling and using product architectures in mechatronic product development

    DEFF Research Database (Denmark)

    Bruun, Hans Peter Lomholt; Mortensen, Niels Henrik

    , experiences by using the architecture representation in a mechatronic development project, and the scope of using the architecture model as a skeleton for a data structure in a PLM system. The fundamental idea for planning and modeling holistic architectures is that an improved understanding of the whole...

  14. Smooth transition autoregressive models - A survey of recent developments

    NARCIS (Netherlands)

    D.J.C. van Dijk (Dick); T. Terasvirta; Ph.H.B.F. Franses (Philip Hans)

    2000-01-01

    textabstractThis paper surveys recent developments related to the smooth transition autoregressive [STAR] time series model and several of its variants. We put emphasis on new methods for testing for STAR nonlinearity, model evaluation, and forecasting. Several useful extensions of the basic STAR

  15. Development of the Next Generation Air Quality Modeling System

    Science.gov (United States)

    A next generation air quality modeling system is being developed at the U.S. EPA to enable modeling of air quality from global to regional to (eventually) local scales. We envision that the system will have three configurations: 1. Global meteorology with seamless mesh refinemen...

  16. Children's Conceptions of Career Choice and Attainment: Model Development

    Science.gov (United States)

    Howard, Kimberly A. S.; Walsh, Mary E.

    2011-01-01

    This article describes a model of children's conceptions of two key career development processes: career choice and career attainment. The model of children's understanding of career choice and attainment was constructed with developmental research and theory into children's understanding of allied phenomena such as their understanding of illness,…

  17. Accident sequence precursor analysis level 2/3 model development

    Energy Technology Data Exchange (ETDEWEB)

    Lui, C.H. [Nuclear Regulatory Commission, Washington, DC (United States); Galyean, W.J.; Brownson, D.A. [Idaho National Engineering Lab., Idaho Falls, ID (United States)] [and others

    1997-02-01

    The US Nuclear Regulatory Commission`s Accident Sequence Precursor (ASP) program currently uses simple Level 1 models to assess the conditional core damage probability for operational events occurring in commercial nuclear power plants (NPP). Since not all accident sequences leading to core damage will result in the same radiological consequences, it is necessary to develop simple Level 2/3 models that can be used to analyze the response of the NPP containment structure in the context of a core damage accident, estimate the magnitude of the resulting radioactive releases to the environment, and calculate the consequences associated with these releases. The simple Level 2/3 model development work was initiated in 1995, and several prototype models have been completed. Once developed, these simple Level 2/3 models are linked to the simple Level 1 models to provide risk perspectives for operational events. This paper describes the methods implemented for the development of these simple Level 2/3 ASP models, and the linkage process to the existing Level 1 models.

  18. Native American Resources: A Model for Collection Development

    Science.gov (United States)

    Taylor, Rhonda Harris; Patterson, Lotsee

    2004-01-01

    This construct for collection development as it relates to Native American resources utilizes Thomas Mann's "Library Research Methods" (1993) concepts of the Traditional Model, the Actual-Practice Model, and the Principle of Least Effort to organize recommendations for both strategies and resources. The three-pronged hierarchical approach to…

  19. Development of Optimized Strength Model of Lateritic Hollow Block ...

    African Journals Online (AJOL)

    The work is an investigation to develop and optimize a model of the compressive strength of lateritic hollow sandcrete block with mound soil inclusion. The study applies the Scheffe's optimization approach to obtain a mathematical model of the form f(xi1,xi2,xi3,,xi4), where xi are proportions of the concrete components, viz: ...

  20. Generativity-Stagnation: Development of a Status Model.

    Science.gov (United States)

    Bradley, Cheryl L.

    1997-01-01

    Reviews theoretical and empirical developments in Erik Erikson's construct of generativity-stagnation. Presents a five-category model describing styles of resolving the issue using combinations of level of involvement or active concern for the growth of self and others; and level of inclusivity or scope of caregiving concern. Discusses model in…

  1. Development of a mathematical model for managing magnitude and ...

    African Journals Online (AJOL)

    A mathematical model was developed for managing m~gnitude and risk · factors of injuries in a manufacturing industry employing System Dynamics (SD) approach. Data were collected using an injury and illness investigation register. These were used to estimate and validate the parameters of the model. The principle of ...

  2. Developing a model of cognitive lockup for user interface engineering

    NARCIS (Netherlands)

    Mioch, T.; Looije, R.; Neerincx, M.A.

    2010-01-01

    This paper presents the development of a cognitive model of cognitive lockup: the tendency of humans to deal with disturbances sequentially, possibly overseeing crucial data from unattended resources so that serious task failures can appear—e.g., in a cockpit or control centre. The proposed model

  3. Model projections for household energy use in developing countries

    NARCIS (Netherlands)

    Daioglou, V.; Ruijven, B.J. van; Vuuren, D.P. van

    2012-01-01

    The residential sector plays an important role in the energy system of developing countries. In this paper we introduce a bottom up simulation model for household energy use. The model describes energy demand for several end-use functions based on a set of physical drivers, such as floor space and

  4. Development of 3D statistical mandible models for cephalometric measurements

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Sung Goo; Yi, Won Jin; Hwang, Soon Jung; Choi, Soon Chul; Lee, Sam Sun; Heo, Min Suk; Huh, Kyung Hoe; Kim, Tae Il [School of Dentistry, Seoul National University, Seoul (Korea, Republic of); Hong, Helen; Yoo, Ji Hyun [Division of Multimedia Engineering, Seoul Women' s University, Seoul (Korea, Republic of)

    2012-09-15

    The aim of this study was to provide sex-matched three-dimensional (3D) statistical shape models of the mandible, which would provide cephalometric parameters for 3D treatment planning and cephalometric measurements in orthognathic surgery. The subjects used to create the 3D shape models of the mandible included 23 males and 23 females. The mandibles were segmented semi-automatically from 3D facial CT images. Each individual mandible shape was reconstructed as a 3D surface model, which was parameterized to establish correspondence between different individual surfaces. The principal component analysis (PCA) applied to all mandible shapes produced a mean model and characteristic models of variation. The cephalometric parameters were measured directly from the mean models to evaluate the 3D shape models. The means of the measured parameters were compared with those from other conventional studies. The male and female 3D statistical mean models were developed from 23 individual mandibles, respectively. The male and female characteristic shapes of variation produced by PCA showed a large variability included in the individual mandibles. The cephalometric measurements from the developed models were very close to those from some conventional studies. We described the construction of 3D mandibular shape models and presented the application of the 3D mandibular template in cephalometric measurements. Optimal reference models determined from variations produced by PCA could be used for craniofacial patients with various types of skeletal shape.

  5. DEVELOPING THE EVALUATION MODEL OF THE LEARNER DEVELOPMENT ACTIVITIES FOR PRIMARY EDUCATIONAL STUDENTS

    OpenAIRE

    Pilaiwan Klangprapan; Paisarn Worakham; Piyatida Panya

    2017-01-01

    The aims of this research study developed a model evaluation to assess the activity development of students in the Primary Education level in Thailand. The research was conducted by the research and development (R&D) process that it was administered in two phases; to investigate on analyzes the concept of student development activities, assessment of student development activities in primary school classes, and theory-driven evaluation and interviews with those involved with the activitie...

  6. DEVELOPMENT OF INTELLIGENT DECISION MAKING MODEL FOR STOCK MARKETS

    OpenAIRE

    Nenortaite, Jovita; Simutis, Rimvydas

    2005-01-01

    This paper is focused on the development of intelligent decision making model which is based on the application of artificial neural networks (ANN) and swarm intelligence technologies. The proposed model is used to generate one-step forward investment decisions. The ANN are used to make the analysis of historical stock returns and to calculate one day forward possible profit, which could be get while following the model proposed decisions, concerning the purchase of the stocks. Subsequently t...

  7. Goethe and the ABC model of flower development.

    Science.gov (United States)

    Coen, E

    2001-06-01

    About 10 years ago, the ABC model for the genetic control of flower development was proposed. This model was initially based on the analysis of mutant flowers but has subsequently been confirmed by molecular analysis. This paper describes the 200-year history behind this model, from the late 18th century when Goethe arrived at his idea of plant metamorphosis, to the genetic studies on flower mutants carried out on Arabidopsis and Antirrhinum in the late 20th century.

  8. Models and automation technologies for the curriculum development

    Directory of Open Access Journals (Sweden)

    V. N. Volkova

    2016-01-01

    Full Text Available The aim of the research was to determine the sequence of the curriculum development stages on the basis of the system analysis, as well as to create models and information technologies for the implementation of thesestages.The methods and the models of the systems’ theory and the system analysis, including methods and automated procedures for structuring organizational aims, models and automated procedures for organizing complex expertise.On the basis of the analysis of existing studies in the field of curriculum modeling, using formal mathematical language, including optimization models, that help to make distribution of disciplines by years and semesters in accordance with the relevant restrictions, it is shown, that the complexity and dimension of these tasks require the development of special software; the problem of defining the input data and restrictions requires a large time investment, that seems to be difficult to provide in real conditions of plans’ developing, thus it is almost impossible to verify the objectivity of the input data and the restrictions in such models. For a complete analysis of the process of curriculum development it is proposed to use the system definition, based on the system-targeted approach. On the basis of this definition the reasonable sequence of the integrated stages for the development of the curriculum was justified: 1 definition (specification of the requirements for the educational content; 2 determining the number of subjects, included in the curriculum; 3 definition of the sequence of the subjects; 4 distribution of subjects by semesters. The models and technologies for the implementation of these stages of curriculum development were given in the article: 1 models, based on the information approach of A.Denisov and the modified degree of compliance with objectives based on Denisov’s evaluation index (in the article the idea of evaluating the degree of the impact of disciplines for realization

  9. Regional knowledge economy development indicative planning system conceptual model

    Directory of Open Access Journals (Sweden)

    Elena Davidovna Vaisman

    2012-12-01

    Full Text Available The subject of the research is the processes of Russian knowledge economy development, its progress on the regional level is taken as a theme, which determined the purpose of research: development of the regional knowledge economy development indicative planning method conceptual model. The methodological base of the research is the knowledge economy concept and supply and demand theory, the methods of comparative and system analysis and theoretical modeling; common generalization and classification methods and regression models are used in the work. As a result, we managed to create the regional knowledge economy development indicative planning method conceptual model, which includes the choice of the types of indicative plans and the justification for the complex of indicators according to the stated requirements to this complex. The model of supply and demand for knowledge dependency from the knowledge cost, allowing to determine the acceptable range for the indicators proceeding from the demand and supply levels and their interrelation, is developed. The obtained results may be used by the regional government authorities while planning the regional innovative development and consulting companies while making the proposals for this development

  10. Modelling Sustainable Development Scenarios of Croatian Power System

    Science.gov (United States)

    Pašičko, Robert; Stanić, Zoran; Debrecin, Nenad

    2010-05-01

    The main objective of power system sustainable development is to provide the security of electricity supply required to underpin economic growth and increase the quality of living while minimizing adverse environmental impacts. New challenges such as deregulation, liberalization of energy markets, increased competition on energy markets, growing demands on security of supply, price insecurities and demand to cut CO2 emissions, are calling for better understanding of electrical systems modelling. Existing models are not sufficient anymore and planners will need to think differently in order to face these challenges. Such a model, on the basis on performed simulations, should enable planner to distinguish between different options and to analyze sustainability of these options. PLEXOS is an electricity market simulation model, used for modeling electrical system in Croatia since 2005. Within this paper, generation expansion scenarios until 2020 developed for Croatian Energy Strategy and modeled in PLEXOS. Development of sustainable Croatian energy scenario was analyzed in the paper - impacts of CO2 emission price and wind generation. Energy Strategy sets goal for 1200 MW from wind power plants in 2020. In order to fully understand its impacts, intermittent nature of electricity generation from wind power plant was modeled. We conclude that electrical system modelling using everyday growing models has proved to be inevitable for sustainable electrical system planning in complex environment in which power plants operate today.

  11. Formulation of consumables management models. Development approach for the mission planning processor working model

    Science.gov (United States)

    Connelly, L. C.

    1977-01-01

    The mission planning processor is a user oriented tool for consumables management and is part of the total consumables subsystem management concept. The approach to be used in developing a working model of the mission planning processor is documented. The approach includes top-down design, structured programming techniques, and application of NASA approved software development standards. This development approach: (1) promotes cost effective software development, (2) enhances the quality and reliability of the working model, (3) encourages the sharing of the working model through a standard approach, and (4) promotes portability of the working model to other computer systems.

  12. Development of a numerical 2-dimensional beach evolution model

    DEFF Research Database (Denmark)

    Baykal, Cüneyt

    2014-01-01

    This paper presents the description of a 2-dimensional numerical model constructed for the simulation of beach evolution under the action of wind waves only over the arbitrary land and sea topographies around existing coastal structures and formations. The developed beach evolution numerical model...... on the gradients of sediment transport rates in cross-shore and longshore directions. The developed models are applied successfully to the SANDYDUCK field experiments and to some conceptual benchmark cases including simulation of rip currents around beach cusps, beach evolution around a single shore perpendicular...

  13. Design models in the development of mechatronic products

    DEFF Research Database (Denmark)

    Habib, Tufail; Brunø, Thomas Ditlev; Nielsen, Kjeld

    2012-01-01

    with the aid of models. The role of software not only as part of the product but also in the development process. These models contribute to product structuring and evaluation of design process by reducing the complexity and their use for product customization.......In view of widespread application of mechatronic systems and the competition to offer customized products at high quality and low cost, there has been considerable attention to introduce new methods and models in this regard. This paper explores design process of mechatronic product development...

  14. Models of economic growth and development in the context of ...

    African Journals Online (AJOL)

    Countries like New Zealand, Iceland, and Denmark offer evidence of this. Models of African development such as the Lagos Plan of Action in terms of the whole continent are discussed within the context of existing impediments to such progress. Keywords: economic growth, economic development, human capital, growth ...

  15. Developing and modelling of ohmic heating for solid food products

    DEFF Research Database (Denmark)

    Feyissa, Aberham Hailu; Frosch, Stina

    developed. The resulting coupled model equations were solved using the Finite Element Method (COMSOL Multi-physics® version 4.2). The experiments were carried out using a newly developed laboratory-scale ohmic heater with different setups e.g., different applied voltages. The temperature profiles...

  16. A Competency-Based Model for Youth Leadership Development

    Science.gov (United States)

    Seemiller, Corey

    2018-01-01

    Whether they are in a leadership program, participate in an organization, or engage in school-based extra-curricular activities, there does not appear to be a shortage of leadership development opportunities for youth. Despite the prominence of these experiences, the lack of youth leadership development models available for educators can pose a…

  17. Conceptual Development af a 3D Product Configuration Model

    DEFF Research Database (Denmark)

    Skauge, Jørn

    2006-01-01

    in the development of IT-systems that support the procedures in companies and in the building industry. In other words, it is a knowledge-based system that helps companies in their daily work. The aim of the project has been to develop and examine conceptual ideas about 3D modelling configurator used in the company...

  18. Development of Prototype Driver Models for Highway Design: Research Update

    Science.gov (United States)

    1999-06-01

    One of the high-priority research areas of the Federal Highway Administration (FHWA) is the development of the Interactive Highway Safety Design Model (IHSDM). The goal of the IHSDM research program is to develop a systematic approach that will allow...

  19. The Highly Engaged School: A Successful Model for Professional Development

    Science.gov (United States)

    Meyer, Bob

    2015-01-01

    Author Bob Meyer, head of the Fay School (Texas) compares professional development strategies in his school to programs in other schools, which he feels are mostly prescriptive in nature, and are based on a deficit model--focused on fixing, rather than developing--and, thus, are not always inspiring. Here Meyer describes the professional…

  20. The Arctic Climate Modeling Program: Professional Development for Rural Teachers

    Science.gov (United States)

    Bertram, Kathryn Berry

    2010-01-01

    The Arctic Climate Modeling Program (ACMP) offered yearlong science, technology, engineering, and math (STEM) professional development to teachers in rural Alaska. Teacher training focused on introducing youth to workforce technologies used in Arctic research. Due to challenges in making professional development accessible to rural teachers, ACMP…

  1. Leadership Identity Development: Challenges in Applying a Developmental Model

    Science.gov (United States)

    Komives, Susan R.; Longerbeam, Susan D.; Mainella, Felicia; Osteen, Laura; Owen, Julie E.; Wagner, Wendy

    2009-01-01

    The leadership identity development (LID) grounded theory (Komives, Owen, Longerbeam, Mainella, & Osteen, 2005) and related LID model (Komives, Longerbeam, Owen, Mainella, & Osteen, 2006) present a framework for understanding how individual college students develop the social identity of being collaborative, relational leaders…

  2. An Evidence-Based Practitioner's Model for Adolescent Leadership Development

    Science.gov (United States)

    Rehm, Christopher J.

    2014-01-01

    This paper proposes a model for youth leadership education based on adolescent development and leadership research in an effort to provide practitioners with a practical blueprint to aid their creation and implementation of high school leadership programs. By focusing on student leader development areas which school level educators can affect,…

  3. Development of a distributed air pollutant dry deposition modeling framework

    Science.gov (United States)

    Satoshi Hirabayashi; Charles N. Kroll; David J. Nowak

    2012-01-01

    A distributed air pollutant dry deposition modeling systemwas developed with a geographic information system (GIS) to enhance the functionality of i-Tree Eco (i-Tree, 2011). With the developed system, temperature, leaf area index (LAI) and air pollutant concentration in a spatially distributed form can be estimated, and based on these and other input variables, dry...

  4. Lilium longiflorum and molecular floral development: the ABCDE model

    NARCIS (Netherlands)

    Benedito, V.A.; Angenent, G.C.; Tuyl, van J.M.; Krens, F.A.

    2004-01-01

    Because lily (Lilium longiflorum Thunb.) is an important cut-flower crop, molecular characterisation of genes that are involved in flower morphology could help breeders to develop novel floral architectures in this species. The early ABC model for flower development emerged more than 10 years ago

  5. Developing a Decision Model of Sustainable Product Design and Development from Product Servicizing in Taiwan

    Science.gov (United States)

    Huang, Yu-Chen; Tu, Jui-Che; Hung, So-Jeng

    2016-01-01

    In response to the global trend of low carbon and the concept of sustainable development, enterprises need to develop R&D for the manufacturing of energy-saving and sustainable products and low carbon products. Therefore, the purpose of this study was to construct a decision model for sustainable product design and development from product…

  6. A Study on Reflection in In-Service Teacher Development: Introducing Reflective Practitioner Development Model

    Science.gov (United States)

    Kayapinar, Ulas

    2016-01-01

    To date, studies on reflection seem to lack concern for in-service teacher development. This article proposes a new EFL reflective practitioner development model (RPDM) for an in-service program that is not only based on the principles of reflection, but that also measures teachers' reflective and self-efficacy development. Focusing on the…

  7. On the development and validation of QSAR models.

    Science.gov (United States)

    Gramatica, Paola

    2013-01-01

    The fundamental and more critical steps that are necessary for the development and validation of QSAR models are presented in this chapter as best practices in the field. These procedures are discussed in the context of predictive QSAR modelling that is focused on achieving models of the highest statistical quality and with external predictive power. The most important and most used statistical parameters needed to verify the real performances of QSAR models (of both linear regression and classification) are presented. Special emphasis is placed on the validation of models, both internally and externally, as well as on the need to define model applicability domains, which should be done when models are employed for the prediction of new external compounds.

  8. Large scale experiments as a tool for numerical model development

    DEFF Research Database (Denmark)

    Kirkegaard, Jens; Hansen, Erik Asp; Fuchs, Jesper

    2003-01-01

    Experimental modelling is an important tool for study of hydrodynamic phenomena. The applicability of experiments can be expanded by the use of numerical models and experiments are important for documentation of the validity of numerical tools. In other cases numerical tools can be applied for im...... hydrodynamic interaction with structures. The examples also show that numerical model development benefits from international co-operation and sharing of high quality results.......Experimental modelling is an important tool for study of hydrodynamic phenomena. The applicability of experiments can be expanded by the use of numerical models and experiments are important for documentation of the validity of numerical tools. In other cases numerical tools can be applied...... for improvement of the reliability of physical model results. This paper demonstrates by examples that numerical modelling benefits in various ways from experimental studies (in large and small laboratory facilities). The examples range from very general hydrodynamic descriptions of wave phenomena to specific...

  9. The Balance Model of Regional Development Management in Certain Territorial Conditions: Development and Application

    Directory of Open Access Journals (Sweden)

    Voloshenko K.

    2014-09-01

    Full Text Available In this article the authors detail the methodology of regional development forecasting with the balance method. They provide with an overview and assessment of the existing models and systems, and their use for the purposes of public administration at the regional level. The article underlines the need to develop a balance approach models for specific territorial conditions. In particular, the authors identify the possibilities of studying the connections between the proportions of material and cash flows within the regional system, and reconciling the needs of a regional economy with the production and resource potentials. The long-term sustainability balance model – a simulation of event-based forecasting – has been developed for the Russian exclave. The authors provide a general description of the balance model, its elements and simulation algorithm. The results of calculations using the balance model for forecasting regional development are provided for three alternative scenarios for the Kaliningrad region for the period until 2018.

  10. Development of an aquifer management model AQMAN3D

    Science.gov (United States)

    Puig, Juan Carlos; Rolon-Collazo, L. I.; Pagan-Trinidad, Ishmael; Krishna, J.H.; Quinones-Aponte, Vicente; Gomez-Gomez, Fernando; Morris, G.L.

    1990-01-01

    A computer code that enables the use of the USGS Modular groundwater flow model for aquifermanagement modeling has been developed. Aquifermanagement techniques integrate groundwater flow modeling with linear quadratic optimization methods for the solution of various aquifer management problems. The model AQMAN3D, is a modified version of a previously developed two-dimensional AQMAN model. The idea of coupling the AQMAN model with the MODULAR model arose because actual groundwater flow systems behave in a three dimensional manner, therefore requiring treatment as such, and due to the widespread use of MODULAR. The use of the AQMAN3D model permits the implementation of the technique known as aquifer managementmodeling. A generalized approach to obtain an optimal solution to an aquifer management problem is proposed, and a sample test problem is presented to illustrate the use of the model. Even though the model provides the hydrologist with a new and powerful investigative tool, its applicability is limited to confined or quasiconfined systems.

  11. Volumetric Intraoperative Brain Deformation Compensation: Model Development and Phantom Validation

    Science.gov (United States)

    DeLorenzo, Christine; Papademetris, Xenophon; Staib, Lawrence H.; Vives, Kenneth P.; Spencer, Dennis D.; Duncan, James S.

    2012-01-01

    During neurosurgery, nonrigid brain deformation may affect the reliability of tissue localization based on preoperative images. To provide accurate surgical guidance in these cases, preoperative images must be updated to reflect the intraoperative brain. This can be accomplished by warping these preoperative images using a biomechanical model. Due to the possible complexity of this deformation, intraoperative information is often required to guide the model solution. In this paper, a linear elastic model of the brain is developed to infer volumetric brain deformation associated with measured intraoperative cortical surface displacement. The developed model relies on known material properties of brain tissue, and does not require further knowledge about intraoperative conditions. To provide an initial estimation of volumetric model accuracy, as well as determine the model’s sensitivity to the specified material parameters and surface displacements, a realistic brain phantom was developed. Phantom results indicate that the linear elastic model significantly reduced localization error due to brain shift, from >16 mm to under 5 mm, on average. In addition, though in vivo quantitative validation is necessary, preliminary application of this approach to images acquired during neocortical epilepsy cases confirms the feasibility of applying the developed model to in vivo data. PMID:22562728

  12. Multiscale Modeling in the Clinic: Drug Design and Development

    Energy Technology Data Exchange (ETDEWEB)

    Clancy, Colleen E.; An, Gary; Cannon, William R.; Liu, Yaling; May, Elebeoba E.; Ortoleva, Peter; Popel, Aleksander S.; Sluka, James P.; Su, Jing; Vicini, Paolo; Zhou, Xiaobo; Eckmann, David M.

    2016-02-17

    A wide range of length and time scales are relevant to pharmacology, especially in drug development, drug design and drug delivery. Therefore, multi-scale computational modeling and simulation methods and paradigms that advance the linkage of phenomena occurring at these multiple scales have become increasingly important. Multi-scale approaches present in silico opportunities to advance laboratory research to bedside clinical applications in pharmaceuticals research. This is achievable through the capability of modeling to reveal phenomena occurring across multiple spatial and temporal scales, which are not otherwise readily accessible to experimentation. The resultant models, when validated, are capable of making testable predictions to guide drug design and delivery. In this review we describe the goals, methods, and opportunities of multi-scale modeling in drug design and development. We demonstrate the impact of multiple scales of modeling in this field. We indicate the common mathematical techniques employed for multi-scale modeling approaches used in pharmacology and present several examples illustrating the current state-of-the-art regarding drug development for: Excitable Systems (Heart); Cancer (Metastasis and Differentiation); Cancer (Angiogenesis and Drug Targeting); Metabolic Disorders; and Inflammation and Sepsis. We conclude with a focus on barriers to successful clinical translation of drug development, drug design and drug delivery multi-scale models.

  13. GEOSPATIAL MODELLING APPROACH FOR 3D URBAN DENSIFICATION DEVELOPMENTS

    Directory of Open Access Journals (Sweden)

    O. Koziatek

    2016-06-01

    Full Text Available With growing populations, economic pressures, and the need for sustainable practices, many urban regions are rapidly densifying developments in the vertical built dimension with mid- and high-rise buildings. The location of these buildings can be projected based on key factors that are attractive to urban planners, developers, and potential buyers. Current research in this area includes various modelling approaches, such as cellular automata and agent-based modelling, but the results are mostly linked to raster grids as the smallest spatial units that operate in two spatial dimensions. Therefore, the objective of this research is to develop a geospatial model that operates on irregular spatial tessellations to model mid- and high-rise buildings in three spatial dimensions (3D. The proposed model is based on the integration of GIS, fuzzy multi-criteria evaluation (MCE, and 3D GIS-based procedural modelling. Part of the City of Surrey, within the Metro Vancouver Region, Canada, has been used to present the simulations of the generated 3D building objects. The proposed 3D modelling approach was developed using ESRI’s CityEngine software and the Computer Generated Architecture (CGA language.

  14. Geospatial Modelling Approach for 3d Urban Densification Developments

    Science.gov (United States)

    Koziatek, O.; Dragićević, S.; Li, S.

    2016-06-01

    With growing populations, economic pressures, and the need for sustainable practices, many urban regions are rapidly densifying developments in the vertical built dimension with mid- and high-rise buildings. The location of these buildings can be projected based on key factors that are attractive to urban planners, developers, and potential buyers. Current research in this area includes various modelling approaches, such as cellular automata and agent-based modelling, but the results are mostly linked to raster grids as the smallest spatial units that operate in two spatial dimensions. Therefore, the objective of this research is to develop a geospatial model that operates on irregular spatial tessellations to model mid- and high-rise buildings in three spatial dimensions (3D). The proposed model is based on the integration of GIS, fuzzy multi-criteria evaluation (MCE), and 3D GIS-based procedural modelling. Part of the City of Surrey, within the Metro Vancouver Region, Canada, has been used to present the simulations of the generated 3D building objects. The proposed 3D modelling approach was developed using ESRI's CityEngine software and the Computer Generated Architecture (CGA) language.

  15. Acting and Teacher Education: Being Model for Identity Development

    Directory of Open Access Journals (Sweden)

    Kemal Sinan Özmen

    2011-04-01

    Full Text Available This study follows three pre-service teachers during three academic semesters in which they took an acting course for teachers and participated in practicum with a special focus on rehearsing and developing their teacher identities. In order to create the necessary context for them, an acting course for pre-service teacher education was designed in parallel with a model which is based on an influential acting theory. This model, namely the BEING (Believe, Experiment, Invent, Navigate, Generate, was also designed by the researcher. The incentive behind designing a model grounded on acting literature was that the relevant literature does not provide trainers with a universal model which can be referred as a manual for running and monitoring acting courses for teachers. In this case study, this model was also tested in terms of its applicability and functionality in practice. Based on analyses of audio taped interviews, session journals and reflections, the five stages of the BEING Model was found to be highly applicable and functional in terms of reflecting the natural development process of teacher identity development. Pre-service teachers displayed a significant development in communication skills and professional identities. Therefore, the BEING model provides a perspective and a philosophy of benefiting from acting literature for teacher educators with little or no knowledge on acting and theatre.

  16. Energy modelling towards low carbon development of Beijing in 2030

    DEFF Research Database (Denmark)

    Zhao, Guangling; Guerrero, Josep M.; Jiang, Kejun

    2017-01-01

    Beijing, as the capital of China, is under the high pressure of climate change and pollution. The consumption of non-renewable energy is one of the most important sources of the CO2 emissions, which cause climate changes. This paper presents a study on the energy system modelling towards renewable...... energy and low carbon development for the city of Beijing. The analysis of energy system modelling is organized in two steps to explore the alternative renewable energy system in Beijing. Firstly, a reference energy system of Beijing is created based on the available data in 2014. The Energy......PLAN, an energy system analysis tool, is chosen to develop the reference energy model. Secondly, this reference model is used to investigate the alternative energy system for integrating renewable energies. Three scenarios are developed towards the energy system of Beijing in 2030, which are: (i) reference...

  17. Clinical strategies and animal models for developing senolytic agents.

    Science.gov (United States)

    Kirkland, James L; Tchkonia, Tamara

    2015-08-01

    Aging is associated with increasing predisposition to multiple chronic diseases. One fundamental aging process that is often operative at sites of the pathology underlying chronic age-related diseases is cellular senescence. Small molecule senolytic agents are being developed. For successful drug development: 1) appropriate animal models of human age-related diseases need to be devised. 2) Models have to be made in which it can be proven that beneficial phenotypic effects are actually caused through clearing senescent cells by putative senolytic agents, as opposed to "off-target" effects of these agents on non-senescent cells. 3) Models are needed to test efficacy of drugs and to uncover potential side effects of senolytic agents. Development of the optimal animal models and clinical trial paradigms for senolytic agents warrants an intensive effort, since senolytic agents, if successful in delaying, preventing, alleviating, or reversing age-related diseases as a group would be transformative. Copyright © 2014 Elsevier Inc. All rights reserved.

  18. Modeling Fractal Dimension Curve of Urban Growth in Developing Countries

    CERN Document Server

    Chen, Yanguang

    2016-01-01

    The growth curve of fractal dimension of cities can be described with sigmoid function such as Boltzmann's equation and logistic function. The logistic models of fractal dimension curves have been presented for the cities in developed countries. However, these models cannot be well fitted to the observational data of fractal dimension of urban form in developing countries (e.g. China). By statistic experiments of fractal parameters, we find that the quadratic Boltzmann's equation can be used to describe fractal dimension change of Chinese cities. For the normalized fractal dimension values, the Boltzmann's equation can be reduced to a quadratic logistic function. In practice, a fractal dimension dataset of urban growth can be approximately fitted with the quadratic logistic function. Thus, a series of models of fractal dimension curve can be proposed for the cities in developing countries. The models are applied to the city of Beijing, Chinese capital, and yield satisfying trend lines of the observational dat...

  19. [Demo-economic models of development: evolution and recent trends].

    Science.gov (United States)

    Bourcier De Carbon, P

    1983-01-01

    Among the recommendations of the 1974 World Population Conference in Bucharest was the elaboration of empirical and inductive demographic-economic models to assist in planning. 1 of the disadvantages of existing models and systems of national income accounting was that income distribution was ignored in favor of the total value of production. Demographic variables were not regarded as endogenous. By the early 1970s, the societal changes attendant on rural exodus and urban unemployment, the increasing absorption of traditional structures into the modern sector, and changes in the roles of women and young people had become obvious, and the need for new models that would reflect such changes was clear. Some macromodels designed to assist medium and long range planning were 1st elaborated in the mid 1970s; the Bachue development models were particularly promising because of their improved database. New models were developed which incorporated consumption problems based on basic needs. An increased focus on the interaction of macroeconomic variables with microsociological and demographic variables, the household and family, and employment and the labor market became necessary. The Bachue models, which had been the most successful of recent models in integrating economic and sociodemographic structures and variables, usually include 4 principal modules which cover demography and the educational system, the economy, employment, and income distribution; basic needs models include a 5th module. The Bachue models are based on a general equilibrium model subject to certain constraints, while the basic needs models are based on dynamic disequilibrium models. A major problem of the models is that technological progress is fundamentally exogenous; there is no intimate link between productivity and elevation of the educational level of the labor force. To avoid unmanageable complexity, households are reconstructed for each period on the basis of the demographic and economic data

  20. Health education leadership development: a conceptual model and competency framework.

    Science.gov (United States)

    Wright, Kathleen; Hann, Neil; McLeroy, Kenneth R; Steckler, Allan; Matulionis, Rose Marie; Auld, M Elaine; Lancaster, Brick; Weber, Diane L

    2003-07-01

    A National Public Health Education Leadership Institute was developed through collaboration among national health education professional organizations, the Centers for Disease Control and Prevention, and a school of public health. The institute provides health educators in leadership positions throughout the country access to a 15-month integrated and sequential professional leadership development program. This article presents a conceptual model and competency framework for that program. The model contains elements considered critical for design of leadership programs in public health and can be used by both professional development and academic programs to shape their design of leadership curricula.

  1. A Software Development Simulation Model of a Spiral Process

    Science.gov (United States)

    Mizell, Carolyn; Malone, Linda

    2007-01-01

    There is a need for simulation models of software development processes other than the waterfall because processes such as spiral development are becoming more and more popular. The use of a spiral process can make the inherently difficult job of cost and schedule estimation even more challenging due to its evolutionary nature, but this allows for a more flexible process that can better meet customers' needs. This paper will present a discrete event simulation model of spiral development that can be used to analyze cost and schedule effects of using such a process in comparison to a waterfall process.

  2. Creation of sustainable leadership development: conceptual model validation:

    OpenAIRE

    Dimovski, Vlado; Penger, Sandra; Peterlin, Judita

    2013-01-01

    Conceptual paper addresses the research question: How can leadership development be managed within organizations? Our proposed answer is presented in the form of conceptual model of sustainable leadership development, based on the theory of multiple intelligences by Howard Gardner and applied to leadership through appreciative inquiry, meaning that leaders possess multiple intelligences which differentiate in their individual profiles and are able to develop a wide span of intelligences durin...

  3. A virtual reality platform for modeling cognitive development

    OpenAIRE

    Jasso, Hector; Triesch, Jochen

    2005-01-01

    We present a virtual reality platform for developing and evaluating embodied models of cognitive development. The platform facilitates structuring of the learning agent, of its visual environment, and of other virtual characters that interact with the learning agent. It allows us to systematically study the role of the visual and social environment for the development of particular cognitive skills in a controlled fashion. We describe how it is currently being used for constructing an embodie...

  4. Building a Model of Leadership DEvelopment for Times of Change

    OpenAIRE

    Klaudio/Andress/Claudio Andres Rivera/Rivera

    2010-01-01

    Promocijas darba anotācija Building a model of leadership development for times of change. The author wants to analyze what happens with potential leaders during times of crises, how crises affect positively or negatively their leadership skills, and which opportunities and threats could be used in order to protect and encourage their leadership development. The objective is to provide the theoretical foundation on how leadership development works in times of change and cris...

  5. Disability identity development model: Voices from the ADA-generation.

    Science.gov (United States)

    Forber-Pratt, Anjali J; Zape, Marianne P

    2017-04-01

    For persons with disabilities, 2015 was a historic year, marking the 25th anniversary of the Americans with Disability Act (ADA) and the 40th anniversary of the passing of the Individuals with Disabilities Education Act (IDEA). It is important to consider the effects of this fundamental shift towards equal opportunity and participation on persons with disabilities' identity development. In practice, however, there are few empirical studies that have looked at this phenomenon and even fewer models of disability identity development. We conducted a qualitative study to explore the disability identity development of college students with disabilities. At two research sites, we conducted individual interviews and observations with 17 college students with varying disabilities, and used in vivo and structural coding analysis to identify and develop themes. The results of this study led to establishing a model of psychosocial identity development for individuals with disabilities. The model highlights four developmental statuses: acceptance, relationship, adoption and engagement. Sharing voices from the participants themselves, we also provide commentary on the possible impacts of this work for healthcare professionals and areas for future research. Our findings suggest that this model of psychosocial disability identity development can help to provide an understanding of the psychological processes that individuals with disabilities go through. The model also has application as a framework for healthcare professionals and psychologists who are working with individuals with disabilities. Copyright © 2016 Elsevier Inc. All rights reserved.

  6. Power Management and Distribution (PMAD) Model Development: Final Report

    Science.gov (United States)

    Metcalf, Kenneth J.

    2011-01-01

    Power management and distribution (PMAD) models were developed in the early 1990's to model candidate architectures for various Space Exploration Initiative (SEI) missions. They were used to generate "ballpark" component mass estimates to support conceptual PMAD system design studies. The initial set of models was provided to NASA Lewis Research Center (since renamed Glenn Research Center) in 1992. They were developed to estimate the characteristics of power conditioning components predicted to be available in the 2005 timeframe. Early 90's component and device designs and material technologies were projected forward to the 2005 timeframe, and algorithms reflecting those design and material improvements were incorporated into the models to generate mass, volume, and efficiency estimates for circa 2005 components. The models are about ten years old now and NASA GRC requested a review of them to determine if they should be updated to bring them into agreement with current performance projections or to incorporate unforeseen design or technology advances. This report documents the results of this review and the updated power conditioning models and new transmission line models generated to estimate post 2005 PMAD system masses and sizes. This effort continues the expansion and enhancement of a library of PMAD models developed to allow system designers to assess future power system architectures and distribution techniques quickly and consistently.

  7. Development of seating accommodation models for soldiers in vehicles.

    Science.gov (United States)

    Zerehsaz, Yaser; Jin, Jionghua Judy; Ebert, Sheila M; Reed, Matthew P

    2017-04-01

    Data from a previous study of soldier driving postures and seating positions were analysed to develop statistical models for defining accommodation of driver seating positions in military vehicles. Regression models were created for seating accommodation applicable to driver positions with a fixed heel point and a range of steering wheel locations in typical tactical vehicles. The models predict the driver-selected seat position as a function of population anthropometry and vehicle layout. These models are the first driver accommodation models considering the effects of body armor and body-borne gear. The obtained results can benefit the design of military vehicles, and the methods can also be extended to be utilised in the development of seating accommodation models for other driving environments where protective equipment affects driver seating posture, such as vehicles used by law-enforcement officers and firefighters. Practitioner Summary: A large-scale laboratory study of soldier driving posture and seating position was designed to focus on tactical vehicle (truck) designs. Regression techniques are utilised to develop accommodation models suitable for tactical vehicles. These are the first seating accommodation models based on soldier data to consider the effects of personal protective equipment and body-borne gear.

  8. Great Plains ASPEN model development: Phosam section. Final topical report

    Energy Technology Data Exchange (ETDEWEB)

    Stern, S S; Kirman, J J

    1985-02-01

    An ASPEN model has been developed of the PHOSAM Section, Section 4600, of the Great Plains Gasification Plant. The bases for this model are the process description given in Section 6.18 of the Great Plains Project Management Plan and the Lummus Phosam Schematic Process Flow Diagram, Dwg. No. SKD-7102-IM-O. The ASPEN model that has been developed contains the complete set of components that are assumed to be in the gasifier effluent. The model is primarily a flowsheet simulation that will give the material and energy balance and equipment duties for a given set of process conditions. The model is unable to predict fully changes in process conditions that would result from load changes on equipment of fixed sizes, such as a rating model would predict. The model can be used to simulate the steady-state operation of the plant at or near design conditions or to design other PHOSAM units. Because of the limited amount of process information that was available, several major process assumptions had to be made in the development of the flowsheet model. Patent literature was consulted to establish the ammonia concentration in the circulating fluid. Case studies were made with the ammonia content of the feed 25% higher and 25% lower than the base feed. Results of these runs show slightly lower recoveries of ammonia with less ammonia in the feed. As expected, the duties of the Stripper and Fractionator reboilers were higher with more ammonia in the feed. 63 references.

  9. Simulation modelling: educational development roles for learning technologists

    Directory of Open Access Journals (Sweden)

    David Riley

    2002-12-01

    Full Text Available Simulation modelling was in the mainstream of CAL development in the 1980s when the late David Squires introduced this author to the Dynamic Modelling System. Since those early days, it seems that simulation modelling has drifted into a learning technology backwater to become a member of Laurillard's underutilized, 'adaptive and productive' media. Referring to her Conversational Framework, Laurillard constructs a pedagogic case for modelling as a productive student activity but provides few references to current practice and available resources. This paper seeks to complement her account by highlighting the pioneering initiatives of the Computers in the Curriculum Project and more recent developments in systems modelling within geographic and business education. The latter include improvements to system dynamics modelling programs such as STELLA®, the publication of introductory textbooks, and the emergence of online resources. The paper indicates several ways in which modelling activities may be approached and identifies some educational development roles for learning technologists. The paper concludes by advocating simulation modelling as an exemplary use of learning technologies - one that realizes their creative-transformative potential.

  10. Analysis of an algae-based CELSS. I - Model development

    Science.gov (United States)

    Holtzapple, Mark T.; Little, Frank E.; Makela, Merry E.; Patterson, C. O.

    1989-01-01

    A steady state chemical model and computer program have been developed for a life support system and applied to trade-off studies. The model is based on human demand for food and oxygen determined from crew metabolic needs. The model includes modules for water recycle, waste treatment, CO2 removal and treatment, and food production. The computer program calculates rates of use and material balance for food, O2, the recycle of human waste and trash, H2O, N2, and food production/supply. A simple noniterative solution for the model has been developed using the steady state rate equations for the chemical reactions. The model and program have been used in system sizing and subsystem trade-off studies of a partially closed life support system.

  11. Theoretical models in the development of advertising for food products

    DEFF Research Database (Denmark)

    Bech-Larsen, Tino; Stacey, Julia

    2005-01-01

    Many advertising people believe that theoretical models hamper creativity and efficiency in the development of advertising messages. This need not be the case, if the theoretical models are sufficiently flexible and intelligible. On the contrary, a workable model that describes how...... the advertisement influences the target may serve as creative inspiration and as a common frame of reference for those involved in the development of advertisements. The means-end-chain model says that an advertisement is effective by connecting the product's attributes (means) and the target's personal values...... (ends). MAPP's experience with the model indicates that it is both flexible and intuitively accessible to practicians. In order to study this MAPP and the Danish Fruit Growers' Association asked an advertising agency to produce two campaign proposals with the purpose of getting young people to eat more...

  12. A rainfall simulation model for agricultural development in Bangladesh

    Directory of Open Access Journals (Sweden)

    M. Sayedur Rahman

    2000-01-01

    Full Text Available A rainfall simulation model based on a first-order Markov chain has been developed to simulate the annual variation in rainfall amount that is observed in Bangladesh. The model has been tested in the Barind Tract of Bangladesh. Few significant differences were found between the actual and simulated seasonal, annual and average monthly. The distribution of number of success is asymptotic normal distribution. When actual and simulated daily rainfall data were used to drive a crop simulation model, there was no significant difference of rice yield response. The results suggest that the rainfall simulation model perform adequately for many applications.

  13. Automatic Generation of 3D Building Models for Sustainable Development

    OpenAIRE

    Sugihara, Kenichi

    2015-01-01

    3D city models are important in urban planning for sustainable development. Urban planners draw maps for efficient land use and a compact city. 3D city models based on these maps are quite effective in understanding what, if this alternative plan is realized, the image of a sustainable city will be. However, enormous time and labour has to be consumed to create these 3D models, using 3D modelling software such as 3ds Max or SketchUp. In order to automate the laborious steps, a GIS and CG inte...

  14. Development and Application of Nonlinear Land-Use Regression Models

    Science.gov (United States)

    Champendal, Alexandre; Kanevski, Mikhail; Huguenot, Pierre-Emmanuel

    2014-05-01

    The problem of air pollution modelling in urban zones is of great importance both from scientific and applied points of view. At present there are several fundamental approaches either based on science-based modelling (air pollution dispersion) or on the application of space-time geostatistical methods (e.g. family of kriging models or conditional stochastic simulations). Recently, there were important developments in so-called Land Use Regression (LUR) models. These models take into account geospatial information (e.g. traffic network, sources of pollution, average traffic, population census, land use, etc.) at different scales, for example, using buffering operations. Usually the dimension of the input space (number of independent variables) is within the range of (10-100). It was shown that LUR models have some potential to model complex and highly variable patterns of air pollution in urban zones. Most of LUR models currently used are linear models. In the present research the nonlinear LUR models are developed and applied for Geneva city. Mainly two nonlinear data-driven models were elaborated: multilayer perceptron and random forest. An important part of the research deals also with a comprehensive exploratory data analysis using statistical, geostatistical and time series tools. Unsupervised self-organizing maps were applied to better understand space-time patterns of the pollution. The real data case study deals with spatial-temporal air pollution data of Geneva (2002-2011). Nitrogen dioxide (NO2) has caught our attention. It has effects on human health and on plants; NO2 contributes to the phenomenon of acid rain. The negative effects of nitrogen dioxides on plants are the reduction of the growth, production and pesticide resistance. And finally, the effects on materials: nitrogen dioxide increases the corrosion. The data used for this study consist of a set of 106 NO2 passive sensors. 80 were used to build the models and the remaining 36 have constituted

  15. Recent Developments on the Turbulence Modeling Resource Website (Invited)

    Science.gov (United States)

    Rumssey, Christopher L.

    2015-01-01

    The NASA Langley Turbulence Model Resource (TMR) website has been active for over five years. Its main goal of providing a one-stop, easily accessible internet site for up-to-date information on Reynolds-averaged Navier-Stokes turbulence models remains unchanged. In particular, the site strives to provide an easy way for users to verify their own implementations of widely-used turbulence models, and to compare the results from different models for a variety of simple unit problems covering a range of flow physics. Some new features have been recently added to the website. This paper documents the site's features, including recent developments, future plans, and open questions.

  16. Development of a bioenergetics model for age-0 American Shad

    Science.gov (United States)

    Sauter, Sally T.

    2011-01-01

    Bioenergetics modeling can be used as a tool to investigate the impact of non-native age-0 American shad (Alosa sapidissima) on reservoir and estuary food webs. The model can increase our understanding of how these fish influence lower trophic levels as well as predatory fish populations that feed on juvenile salmonids. Bioenergetics modeling can be used to investigate ecological processes, evaluate alternative research hypotheses, provide decision support, and quantitative prediction. Bioenergetics modeling has proven to be extremely useful in fisheries research (Ney et al. 1993,Chips and Wahl 2008, Petersen et al. 2008). If growth and diet parameters are known, the bioenergetics model can be used to quantify the relative amount of zooplankton or insects consumed by age-0 American shad. When linked with spatial and temporal information on fish abundance, model output can guide inferential hypothesis development to demonstrate where the greatest impacts of age-0 American shad might occur. Bioenergetics modeling is particularly useful when research questions involve multiple species and trophic levels (e.g. plankton communities). Bioenergetics models are mass-balance equations where the energy acquired from food is partitioned between maintenance costs, waste products, and growth (Winberg 1956). Specifically, the Wisconsin bioenergetics model (Hanson et al. 1997) is widely used in fisheries science. Researchers have extensively tested, reviewed, and improved on this modeling approach for over 30 years (Petersen et al. 2008). Development of a bioenergetics model for any species requires three key components: 1) determine physiological parameters for the model through laboratory experiments or incorporate data from a closely related species, 2) corroboration of the model with growth and consumption estimates from independent research, and 3) error analysis of model parameters. Wisconsin bioenergetics models have been parameterized for many of the salmonids and

  17. Development of numerical Grids for UZ Flow and Transport Modeling

    Energy Technology Data Exchange (ETDEWEB)

    P. Dobson

    2004-08-31

    This report describes the methods used to develop numerical grids of the unsaturated hydrogeologic system beneath Yucca Mountain, Nevada. Numerical grid generation is an integral part of the development of the unsaturated zone (UZ) flow and transport model, a complex, three-dimensional (3-D) model of Yucca Mountain. This revision contains changes made to improve the clarity of the description of grid generation. The numerical grids, developed using current geologic, hydrogeologic, and mineralogic data, provide the necessary framework to: (1) develop calibrated hydrogeologic property sets and flow fields, (2) test conceptual hypotheses of flow and transport, and (3) predict flow and transport behavior under a variety of climatic and thermal-loading conditions. The technical scope, content, and management for the current revision of this report are described in the planning document ''Technical Work Plan for: Unsaturated Zone Flow Analysis and Model Report Integration'' (BSC 2004 [DIRS 169654], Section 2). Grids generated and documented in this report supersede those documented in Revision 00 of this report, ''Development of Numerical Grids for UZ Flow and Transport Modeling'' (BSC 2001 [DIRS 159356]). The grids presented in this report are the same as those developed in Revision 01 (BSC 2003 [DIRS 160109]); however, the documentation of the development of the grids in Revision 02 has been updated to address technical inconsistencies and achieve greater transparency, readability, and traceability. The constraints, assumptions, and limitations associated with this report are discussed in the appropriate sections that follow.

  18. Model developer`s appendix to the model documentation report: NEMS macroeconomic activity module

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1994-07-15

    The NEMS Macroeconomic Activity Module (MAM) tested here was used to generate the Annual Energy Outlook 1994 (AEO94). MAM is a response surface model, not a structural model, composed of three submodules: the National Submodule, the Interindustry Submodule, and the Regional Submodule. Contents of this report are as follows: properties of the mathematical solution; NEMS MAM empirical basis; and scenario analysis. Scenario analysis covers: expectations for scenario analysis; historical world oil price scenario; AEO94 high world oil price scenario; AEO94 low world oil price scenario; and immediate increase world oil price scenario.

  19. Hydraulic modeling development and application in water resources engineering

    Science.gov (United States)

    Simoes, Francisco J.; Yang, Chih Ted; Wang, Lawrence K.

    2015-01-01

    The use of modeling has become widespread in water resources engineering and science to study rivers, lakes, estuaries, and coastal regions. For example, computer models are commonly used to forecast anthropogenic effects on the environment, and to help provide advanced mitigation measures against catastrophic events such as natural and dam-break floods. Linking hydraulic models to vegetation and habitat models has expanded their use in multidisciplinary applications to the riparian corridor. Implementation of these models in software packages on personal desktop computers has made them accessible to the general engineering community, and their use has been popularized by the need of minimal training due to intuitive graphical user interface front ends. Models are, however, complex and nontrivial, to the extent that even common terminology is sometimes ambiguous and often applied incorrectly. In fact, many efforts are currently under way in order to standardize terminology and offer guidelines for good practice, but none has yet reached unanimous acceptance. This chapter provides a view of the elements involved in modeling surface flows for the application in environmental water resources engineering. It presents the concepts and steps necessary for rational model development and use by starting with the exploration of the ideas involved in defining a model. Tangible form of those ideas is provided by the development of a mathematical and corresponding numerical hydraulic model, which is given with a substantial amount of detail. The issues of model deployment in a practical and productive work environment are also addressed. The chapter ends by presenting a few model applications highlighting the need for good quality control in model validation.

  20. The development of the Professional Values Model in Nursing.

    Science.gov (United States)

    Kaya, Ayla; Boz, İlkay

    2017-01-01

    One of the most important criteria for professionalism is accumulation of knowledge that is usable in professional practice. Nursing models and theories are important elements of accumulating nursing knowledge and have a chance to guarantee the ethical professional practice. In recent years, there has been an increase in the use of models in nursing research and newly created terminology has started to be used in nursing. In this study, a new model, termed as the Professional Values Model, developed by the authors was described. Concepts comprising the conceptual framework of the model and relations between the concepts were explained. It is assumed that awareness about concepts of the model will increase not only the patients' satisfaction with nursing care, but also the nurses' job satisfaction and quality of nursing care. Contemporary literature has been reviewed and synthesized to develop this theoretical paper on the Professional Values Model in nursing. Having high values in nursing increases job satisfaction, which results in the improvement of patient care and satisfaction. Also, individual characteristics are effective in the determination of individual needs, priorities, and values. This relation, proved through research about the Professional Values Model, has been explained. With development of these concepts, individuals' satisfaction with care and nurses' job satisfaction will be enhanced, which will increase the quality of nursing care. Most importantly, nurses can take proper decisions about ethical dilemmas and take ethical action when they take these values into consideration when giving care. The Professional Values Model seems suitable for nurse managers and it is expected that testing will improve it. Implementation of the Professional Values Model by nurse managers may increase motivation of nurses they work with. It is suggested that guidance by the Professional Values Model may help in enhancement of motivation efforts of the nurse managers

  1. Recent Developments of the Florida Public Hurricane Loss Model

    Science.gov (United States)

    Cocke, S.; Shin, D. W.; Annane, B.

    2016-12-01

    Catastrophe models are used extensively by the insurance industry to estimate losses due to natural hazards such as hurricanes and earthquakes. In the state of Florida, primary insurers for hurricane damage to residential properties are required by law to use certified catastrophe models to establish their premiums and capital reserves. The Florida Public Hurricane Loss Model (FPHLM) is one of only five certified catastrophe models in Florida, and the only non-commercial model certified. The FPHLM has been funded through the Florida Legislature and is overseen by the Florida Office of Insurance Regulation (OIR). The model was developed by a consortium of universities and private consultants primary located in Florida, but includes some partners outside of the state. The FPHLM has met Florida requirements since 2006 and has undergone continuous evolution to maintain state-of-the-art capabilities and changes in state requirements established by the Florida Commission on Hurricane Loss Projection Methodology. Recently the model has been undergoing major enhancement to incorporate damage due to flooding, which not only includes hurricane floods but floods due to all potential natural hazards. This work is being done in anticipation of future changes in the National Flood Insurance Program (NFIP) that will bring private insurers to the flood market. The model will incorporate a surge model as well as an inland flood model. We will present progress on these recent enhancements along with additional progress of the model.

  2. SIMULATION MODEL BASED ON REGIONAL DEVELOPMENT AND VIRTUAL CHANGES

    Directory of Open Access Journals (Sweden)

    Petr Dlask

    2015-10-01

    Full Text Available This paper reports on change as an indicator that can be provide more focused goals in studies of development. The paper offers an answer to the question: How might management gain information from a simulation model and thus influence reality through pragmatic changes. We focus on where and when to influence, manage, and control basic technical-economic proposals. These proposals are mostly formed as simulation models. Unfortunately, however, they do not always provide an explanation of formation changes. A wide variety of simulation tools have become available, e.g. Simulink, Wolfram SystemModeler, VisSim, SystemBuild, STELLA, Adams, SIMSCRIPT, COMSOL Multiphysics, etc. However, there is only limited support for the construction of simulation models of a technical-economic nature. Mathematics has developed the concept of differentiation. Economics has developed the concept of marginality. Technical-economic design has yet to develop an equivalent methodology. This paper discusses an,alternative approach that uses the phenomenon of change, and provides a way from professional knowledge, which can be seen as a purer kind of information, to a more dynamic computing model (a simulation model that interprets changes as method. The validation of changes, as a result for use in managerial decision making, and condition for managerial decision making, can thus be improved.

  3. Developing a Patient-Centered Radiology Process Model.

    Science.gov (United States)

    Swan, J Shannon; Pandharipande, Pari V; Salazar, Gloria M

    2016-05-01

    There has been increasing interest in the process of care that patients experience. To keep step with the rest of medicine, our specialty should be designing metrics that assess the overall experience of patients seeking care in radiology departments. A recent memo from the ACR chair calls for more work in this area. The aim of this study was to develop a patient-centered model for the experience of radiologic care, which may be helpful in addressing this need. Using principles of multiattribute utility theory and psychometric theory as well as recent literature, a model was developed for a patient-centered index that could be used in radiology facilities. A model was developed that concisely incorporates patient-centeredness of both radiologists and staff members (communication with patient and referrers, competence, and pain control) as well as patient- and process-related issues such as costs, procedural morbidity, access to care, appointment duration, waiting, timing of appointments, cleanliness of facility, and coordination with clinical services. The overall radiology process model was constructed as a set of nested models, which allow more integrated detail within the domains of patient experience. This model and others like it may help the ACR develop quality metrics to reasonably quantify the patient experience. Copyright © 2016 American College of Radiology. Published by Elsevier Inc. All rights reserved.

  4. Understanding Mammalian Germ Line Development with In Vitro Models.

    Science.gov (United States)

    Martínez-Arroyo, Ana M; Míguez-Forján, Jose M; Remohí, Jose; Pellicer, Antonio; Medrano, Jose V

    2015-09-15

    Germ line development is crucial in organisms with sexual reproduction to complete their life cycle. In mammals, knowledge about germ line development is based mainly on the mouse model, in which genetic and epigenetic events are well described. However, little is known about how germ line development is orchestrated in humans, especially in the earliest stages. New findings derived from human in vitro models to obtain germ cells can shed light on these questions. This comprehensive review summarizes the current knowledge about mammalian germ line development, emphasizing the state of the art obtained from in vitro models for germ cell-like cell derivation. Current knowledge of the pluripotency cycle and germ cell specification has allowed different in vitro strategies to obtain germ cells with proven functionality in mouse models. Several reports during the last 10 years show that in vitro germ cell derivation with proven functionality to generate a healthy offspring is possible in mice. However, differences in the embryo development and pluripotency potential between human and mouse make it difficult to extrapolate these results. Further efforts on both human and mouse in vitro models to obtain germ cells from pluripotent stem cells may help to elucidate how human physiological events take place; therefore, therapeutic strategies can also be considered.

  5. Dynamic simulation of sustainable farm development scenarios using cognitive modeling

    Directory of Open Access Journals (Sweden)

    Tuzhyk Kateryna

    2017-03-01

    Full Text Available Dynamic simulation of sustainable farm development scenarios using cognitive modeling. The paper presents a dynamic simulation system of sustainable development scenarios on farms using cognitive modeling. The system incorporates relevant variables which affect the sustainable development of farms. Its user provides answers to strategic issues connected with the level of farm sustainability over a long-term perspective of dynamic development. The work contains a description of the model structure as well as the results of simulations carried out on 16 farms in northern Ukraine. The results show that the process of sustainability is based mainly on the potential for innovation in agricultural production and biodiversity. The user is able to simulate various scenarios for the sustainable development of a farm and visualize the influence of factors on the economic and social situation, as well as on environmental aspects. Upon carrying out a series of simulations, it was determined that the development of farms characterized by sustainable development is based on additional profit, which serves as the main motivation for transforming a conventional farm into a sustainable one. Nevertheless, additional profit is not the only driving force in the system of sustainable development. The standard of living, market condition, and legal regulations as well as government support also play a significant motivational role.

  6. Recent developments in animal models of drug relapse.

    Science.gov (United States)

    Marchant, Nathan J; Li, Xuan; Shaham, Yavin

    2013-08-01

    Drug craving and relapse to drug use during abstinence are defining features of addiction. Evidence indicates that drug craving and relapse in humans are often provoked by acute exposure to the self-administered drug, drug-associated cues, or stress. During the last two decades, this clinical scenario has been primarily studied at the preclinical level using the classical reinstatement model. However, a single preclinical model cannot capture the complicated nature of human drug relapse. Therefore, more recently, we and others have developed several other models to study different facets of human drug relapse. In this review, we introduce and discuss recent findings from these other relapse models, including incubation of drug craving, reacquisition and resurgence models, and punishment-based and conflict-based relapse models. Published by Elsevier Ltd.

  7. Animal models for dengue vaccine development and testing.

    Science.gov (United States)

    Na, Woonsung; Yeom, Minjoo; Choi, Il-Kyu; Yook, Heejun; Song, Daesub

    2017-07-01

    Dengue fever is a tropical endemic disease; however, because of climate change, it may become a problem in South Korea in the near future. Research on vaccines for dengue fever and outbreak preparedness are currently insufficient. In addition, because there are no appropriate animal models, controversial results from vaccine efficacy assessments and clinical trials have been reported. Therefore, to study the mechanism of dengue fever and test the immunogenicity of vaccines, an appropriate animal model is urgently needed. In addition to mouse models, more suitable models using animals that can be humanized will need to be constructed. In this report, we look at the current status of model animal construction and discuss which models require further development.

  8. Measuring broadband in Europe: : development of a market model and performance index using structural equations modelling

    NARCIS (Netherlands)

    Lemstra, W.; Voogt, B.; Gorp, van N.

    2015-01-01

    This contribution reports on the development of a performance index and underlying market model with application to broadband developments in the European Union. The Structure–Conduct–Performance paradigm provides the theoretical grounding. Structural equations modelling was applied to determine the

  9. Protein adsorption on nanoparticles: model development using computer simulation.

    Science.gov (United States)

    Shao, Qing; Hall, Carol K

    2016-10-19

    The adsorption of proteins on nanoparticles results in the formation of the protein corona, the composition of which determines how nanoparticles influence their biological surroundings. We seek to better understand corona formation by developing models that describe protein adsorption on nanoparticles using computer simulation results as data. Using a coarse-grained protein model, discontinuous molecular dynamics simulations are conducted to investigate the adsorption of two small proteins (Trp-cage and WW domain) on a model nanoparticle of diameter 10.0 nm at protein concentrations ranging from 0.5 to 5 mM. The resulting adsorption isotherms are well described by the Langmuir, Freundlich, Temkin and Kiselev models, but not by the Elovich, Fowler-Guggenheim and Hill-de Boer models. We also try to develop a generalized model that can describe protein adsorption equilibrium on nanoparticles of different diameters in terms of dimensionless size parameters. The simulation results for three proteins (Trp-cage, WW domain, and GB3) on four nanoparticles (diameter  =  5.0, 10.0, 15.0, and 20.0 nm) illustrate both the promise and the challenge associated with developing generalized models of protein adsorption on nanoparticles.

  10. Protein adsorption on nanoparticles: model development using computer simulation

    Science.gov (United States)

    Shao, Qing; Hall, Carol K.

    2016-10-01

    The adsorption of proteins on nanoparticles results in the formation of the protein corona, the composition of which determines how nanoparticles influence their biological surroundings. We seek to better understand corona formation by developing models that describe protein adsorption on nanoparticles using computer simulation results as data. Using a coarse-grained protein model, discontinuous molecular dynamics simulations are conducted to investigate the adsorption of two small proteins (Trp-cage and WW domain) on a model nanoparticle of diameter 10.0 nm at protein concentrations ranging from 0.5 to 5 mM. The resulting adsorption isotherms are well described by the Langmuir, Freundlich, Temkin and Kiselev models, but not by the Elovich, Fowler-Guggenheim and Hill-de Boer models. We also try to develop a generalized model that can describe protein adsorption equilibrium on nanoparticles of different diameters in terms of dimensionless size parameters. The simulation results for three proteins (Trp-cage, WW domain, and GB3) on four nanoparticles (diameter  =  5.0, 10.0, 15.0, and 20.0 nm) illustrate both the promise and the challenge associated with developing generalized models of protein adsorption on nanoparticles.

  11. Dependability modeling and assessment in UML-based software development.

    Science.gov (United States)

    Bernardi, Simona; Merseguer, José; Petriu, Dorina C

    2012-01-01

    Assessment of software nonfunctional properties (NFP) is an important problem in software development. In the context of model-driven development, an emerging approach for the analysis of different NFPs consists of the following steps: (a) to extend the software models with annotations describing the NFP of interest; (b) to transform automatically the annotated software model to the formalism chosen for NFP analysis; (c) to analyze the formal model using existing solvers; (d) to assess the software based on the results and give feedback to designers. Such a modeling→analysis→assessment approach can be applied to any software modeling language, be it general purpose or domain specific. In this paper, we focus on UML-based development and on the dependability NFP, which encompasses reliability, availability, safety, integrity, and maintainability. The paper presents the profile used to extend UML with dependability information, the model transformation to generate a DSPN formal model, and the assessment of the system properties based on the DSPN results.

  12. Development of a surgical site infection prediction model in orthopaedic trauma: The Denver Health Model.

    Science.gov (United States)

    Reese, Sara M; Knepper, Bryan; Young, Heather L; Mauffrey, Cyril

    2017-12-01

    The CDC's National Healthcare Safety Network's (NHSN) current risk adjustment model for surgical site infections (SSI) following open reduction internal fixation (ORIF) of long bone fractures is a suboptimal predictor of risk. We hypothesized that by including variables known to be associated with SSI following ORIF, we would develop a model that would increase the accuracy and predictability of SSI risk. Patients who underwent ORIF of a long bone between January 1, 2012 and December 31, 2014 were included in the study (n=1543). Patient risk factors, injury risk factors and perioperative risk factors were considered in the development of this model. We developed a risk prediction model for SSI following ORIF and then applied this to a new dataset of ORIF to determine the expected number of infections. This was compared to the expected number of infections calculated using the NHSN risk adjusted model. The final multivariate model included age (odds ratio: 1.02, p-valuemodel, indicating that our model more accurate in estimating infection risk. When the developed model was used to predict the number of expected infections on a new dataset from 2015, 36.3 SSI were expected compared to 5.7 calculated by the NHSN model. The model that was developed uses five easily identifiable risk factors that result in a more accurate prediction of infection at our facility than the currently used model. Prognostic and epidemiologic study, level III. Copyright © 2017 Elsevier Ltd. All rights reserved.

  13. Models of price development on world market for cocoa beans

    Directory of Open Access Journals (Sweden)

    Pavel Syrovátka

    2008-01-01

    Full Text Available This paper is focused on the modelling and simulating the development of the price of cocoa beans on the world market. The developed models were based on the dependence of the level of the world price of cocoa beans on the world stock to grindings ratio of the beans in the last crop year. The ICCO databases from 1960/1961 to 2005/2006 crop years were used for the estimation of the parameters in the investigated forms of the price model. The linear and logarithmic-linear categories of the price models were studied in this paper. Within the linear forms of the price models; the single linear construction and the linear construction with dummy time variable were specified and tested. Within the logarithmic-linear category of the price models; the error correction model and autoregressive model were examined. From the point of view of statistical verification and from the low value of deviation of the simulated world price of cocoa beans for the 2005/2006 period from the actual price level of price for this crop period, the logarithmic-linear form of model with the error correction achieved the best results. Acceptable results were also obtained by means of the modified price model with the error correction component. By using the logarithmic-linear form of error correction model, the world price of the cocoa beans for the crop period 2006/2007 will achieve the following value 1047 SDR · t−1.Under the modified error correction model, the level of the world price will be 1050 SDR · t−1.

  14. Relational grounding facilitates development of scientifically useful multiscale models.

    Science.gov (United States)

    Hunt, C Anthony; Ropella, Glen E P; Lam, Tai ning; Gewitz, Andrew D

    2011-09-27

    We review grounding issues that influence the scientific usefulness of any biomedical multiscale model (MSM). Groundings are the collection of units, dimensions, and/or objects to which a variable or model constituent refers. To date, models that primarily use continuous mathematics rely heavily on absolute grounding, whereas those that primarily use discrete software paradigms (e.g., object-oriented, agent-based, actor) typically employ relational grounding. We review grounding issues and identify strategies to address them. We maintain that grounding issues should be addressed at the start of any MSM project and should be reevaluated throughout the model development process. We make the following points. Grounding decisions influence model flexibility, adaptability, and thus reusability. Grounding choices should be influenced by measures, uncertainty, system information, and the nature of available validation data. Absolute grounding complicates the process of combining models to form larger models unless all are grounded absolutely. Relational grounding facilitates referent knowledge embodiment within computational mechanisms but requires separate model-to-referent mappings. Absolute grounding can simplify integration by forcing common units and, hence, a common integration target, but context change may require model reengineering. Relational grounding enables synthesis of large, composite (multi-module) models that can be robust to context changes. Because biological components have varying degrees of autonomy, corresponding components in MSMs need to do the same. Relational grounding facilitates achieving such autonomy. Biomimetic analogues designed to facilitate translational research and development must have long lifecycles. Exploring mechanisms of normal-to-disease transition requires model components that are grounded relationally. Multi-paradigm modeling requires both hyperspatial and relational grounding.

  15. Relational grounding facilitates development of scientifically useful multiscale models

    Directory of Open Access Journals (Sweden)

    Lam Tai

    2011-09-01

    Full Text Available Abstract We review grounding issues that influence the scientific usefulness of any biomedical multiscale model (MSM. Groundings are the collection of units, dimensions, and/or objects to which a variable or model constituent refers. To date, models that primarily use continuous mathematics rely heavily on absolute grounding, whereas those that primarily use discrete software paradigms (e.g., object-oriented, agent-based, actor typically employ relational grounding. We review grounding issues and identify strategies to address them. We maintain that grounding issues should be addressed at the start of any MSM project and should be reevaluated throughout the model development process. We make the following points. Grounding decisions influence model flexibility, adaptability, and thus reusability. Grounding choices should be influenced by measures, uncertainty, system information, and the nature of available validation data. Absolute grounding complicates the process of combining models to form larger models unless all are grounded absolutely. Relational grounding facilitates referent knowledge embodiment within computational mechanisms but requires separate model-to-referent mappings. Absolute grounding can simplify integration by forcing common units and, hence, a common integration target, but context change may require model reengineering. Relational grounding enables synthesis of large, composite (multi-module models that can be robust to context changes. Because biological components have varying degrees of autonomy, corresponding components in MSMs need to do the same. Relational grounding facilitates achieving such autonomy. Biomimetic analogues designed to facilitate translational research and development must have long lifecycles. Exploring mechanisms of normal-to-disease transition requires model components that are grounded relationally. Multi-paradigm modeling requires both hyperspatial and relational grounding.

  16. Engine System Model Development for Nuclear Thermal Propulsion

    Science.gov (United States)

    Nelson, Karl W.; Simpson, Steven P.

    2006-01-01

    In order to design, analyze, and evaluate conceptual Nuclear Thermal Propulsion (NTP) engine systems, an improved NTP design and analysis tool has been developed. The NTP tool utilizes the Rocket Engine Transient Simulation (ROCETS) system tool and many of the routines from the Enabler reactor model found in Nuclear Engine System Simulation (NESS). Improved non-nuclear component models and an external shield model were added to the tool. With the addition of a nearly complete system reliability model, the tool will provide performance, sizing, and reliability data for NERVA-Derived NTP engine systems. A new detailed reactor model is also being developed and will replace Enabler. The new model will allow more flexibility in reactor geometry and include detailed thermal hydraulics and neutronics models. A description of the reactor, component, and reliability models is provided. Another key feature of the modeling process is the use of comprehensive spreadsheets for each engine case. The spreadsheets include individual worksheets for each subsystem with data, plots, and scaled figures, making the output very useful to each engineering discipline. Sample performance and sizing results with the Enabler reactor model are provided including sensitivities. Before selecting an engine design, all figures of merit must be considered including the overall impacts on the vehicle and mission. Evaluations based on key figures of merit of these results and results with the new reactor model will be performed. The impacts of clustering and external shielding will also be addressed. Over time, the reactor model will be upgraded to design and analyze other NTP concepts with CERMET and carbide fuel cores.

  17. Drug discovery and development for neglected diseases: the DNDi model

    Directory of Open Access Journals (Sweden)

    Eric Chatelain

    2011-03-01

    Full Text Available Eric Chatelain, Jean-Robert IosetDrugs for Neglected Diseases Initiative (DNDi, Geneva, SwitzerlandAbstract: New models of drug discovery have been developed to overcome the lack of modern and effective drugs for neglected diseases such as human African trypanosomiasis (HAT; sleeping sickness, leishmaniasis, and Chagas disease, which have no financial viability for the pharmaceutical industry. With the purpose of combining the skills and research capacity in academia, pharmaceutical industry, and contract researchers, public–private partnerships or product development partnerships aim to create focused research consortia that address all aspects of drug discovery and development. These consortia not only emulate the projects within pharmaceutical and biotechnology industries, eg, identification and screening of libraries, medicinal chemistry, pharmacology and pharmacodynamics, formulation development, and manufacturing, but also use and strengthen existing capacity in disease-endemic countries, particularly for the conduct of clinical trials. The Drugs for Neglected Diseases initiative (DNDi has adopted a model closely related to that of a virtual biotechnology company for the identification and optimization of drug leads. The application of this model to the development of drug candidates for the kinetoplastid infections of HAT, Chagas disease, and leishmaniasis has already led to the identification of new candidates issued from DNDi’s own discovery pipeline. This demonstrates that the model DNDi has been implementing is working but its DNDi, neglected diseases sustainability remains to be proven.Keywords: R&D, screening, lead optimization, human African trypanosomiasis, leishmaniasis, Chagas disease, product development partnerships

  18. System Simulation Modeling: A Case Study Illustration of the Model Development Life Cycle

    Science.gov (United States)

    Janice K. Wiedenbeck; D. Earl Kline

    1994-01-01

    Systems simulation modeling techniques offer a method of representing the individual elements of a manufacturing system and their interactions. By developing and experimenting with simulation models, one can obtain a better understanding of the overall physical system. Forest products industries are beginning to understand the importance of simulation modeling to help...

  19. ESPC Common Model Architecture Earth System Modeling Framework (ESMF) Software and Application Development

    Science.gov (United States)

    2015-09-30

    1 DISTRIBUTION STATEMENT A. Approved for public release; distribution is unlimited. ESPC Common Model Architecture Earth System Modeling...Capability (NUOPC) was established between NOAA and Navy to develop a common software architecture for easy and efficient interoperability. The...model architecture and other software-related standards in this project. OBJECTIVES NUOPC proposes to accelerate improvement of our national

  20. Developing Model-Making and Model-Breaking Skills Using Direct Measurement Video-Based Activities

    Science.gov (United States)

    Vonk, Matthew; Bohacek, Peter; Militello, Cheryl; Iverson, Ellen

    2017-01-01

    This study focuses on student development of two important laboratory skills in the context of introductory college-level physics. The first skill, which we call model making, is the ability to analyze a phenomenon in a way that produces a quantitative multimodal model. The second skill, which we call model breaking, is the ability to critically…

  1. Papaya Development Model As A Competitive Local Superior Commodity

    Directory of Open Access Journals (Sweden)

    Reny Sukmawani

    2014-12-01

    Full Text Available The aim of this research is to study the comparative advantage and papaya competitive and to design its development model by using the approach of local base agriculture development. This research uses survey method. The resulting research shows that papaya is a base commodity that has comparative advantage and competitive. The development papaya in the district of Sukabumi is quite good bases on eight superior creations. But in order to be the main sector in economic development and has a competition, the development of papaya must concern to its influence factors. In supporting papaya development as a competitive local superior commodity, it needs to be done some efforts are as follows: (1 increase a skillful worker; (2 improve business management; (3 increase papaya productivity by using technology and study papaya planted technology in specific local superior commodity; (4 develop the involvement of the business relation; (5 provide market information and information technology network; and (6 improve infrastructures.

  2. A representation model for developing double-sided assembly line balancing model: An industrial case study

    Science.gov (United States)

    Hamzas, M. F. M. A.; Bareduan, S. A.; Zakaria, M. Z.; Ghazali, S.; Zairi, S.

    2017-09-01

    Assembly line balancing is an active area of optimisation research, in which the main purposes is to assign a task to a workstation so that the required time among workstations is approximately the same. This paper describes a methodology for developing a model. In this study, a motorcycle assembly plant has been selected as the main place of research study. The basic idea is how to represent and evaluate the assembly line model. The developed methodology is based on real life application problems faced by the industry. By using an applicable model selection procedure, a model representation is discussed. This paper presents a basic knowledge on model representation for an industrial case study related to a double-sided assembly line system. It is apparent that the developed model can evaluate the optimisation problems and be used for future system upgrades. The data was analyzed and it is suitable for mathematical programming model.

  3. Semantic Model Driven Architecture Based Method for Enterprise Application Development

    Science.gov (United States)

    Wu, Minghui; Ying, Jing; Yan, Hui

    Enterprise applications have the requirements of meeting dynamic businesses processes and adopting lasted technologies flexibly, with to solve the problems caused by the nature of heterogeneous characteristic. Service-Oriented Architecture (SOA) is becoming a leading paradigm for business process integration. This research work focuses on business process modeling, proposes a semantic model-driven development method named SMDA combined with the Ontology and Model-Driven Architecture (MDA) technologies. The architecture of SMDA is presented in three orthogonal perspectives. (1) Vertical axis is the MDA 4 layers, the focus is UML profiles in M2 (meta-model layer) for ontology modeling, and three abstract levels: CIM, PIM and PSM modeling respectively. (2) Horizontal axis is different concerns involved in the development: Process, Application, Information, Organization, and Technology. (3) Traversal Axis is referred to aspects that have influence on other models of the cross-cutting axis: Architecture, Semantics, Aspect, and Pattern. The paper also introduces the modeling and transformation process in SMDA, and describes dynamic service composition supports briefly.

  4. Development of the Integrated Environmental Control Model. Quarterly progress report

    Energy Technology Data Exchange (ETDEWEB)

    Rubin, E.S.; Berkenpas, M.B.; Kalagnanam, J.

    1993-04-01

    The purpose of this contract is to develop and refine the Integrated Environmental Control Model (IECM) created and enhanced by Carnegie Mellon University (CMU) for the US Department of Energy`s Pittsburgh Energy Technology Center (DOE/PETC) under contract Numbers FG22-83PC60271 and AC22-87PC79864. In its current configuration, the IECM provides a capability to model various conventional and advanced processes for controlling air pollutant emissions from coal-fired power plants before, during, or after combustion. The principal purpose of the model is to calculate the performance, emissions, and cost of power plant configurations employing alternative environmental control methods. The model consists of various control technology modules, which may be integrated into a complete utility plant in any desired combination. In contrast to conventional deterministic models, the IECM offers the unique capability to assign probabilistic values to all model input parameters, and to obtain probabilistic outputs in the form of cumulative distribution functions indicating the likelihood of different costs and performance results. The work in this contract is divided into two phases. Phase I deals with further developing the existing version of the IECM and training PETC personnel on the effective use of the model. Phase II deals with creating new technology modules, linking the IECM with PETC databases, and training PETC personnel on the effective use of the updated model.

  5. Development of a Geoid Model by Geometric Method

    Science.gov (United States)

    Mishra, Upendra Nath; Ghosh, Jayanta Kumar

    2017-12-01

    Engineering projects require orthometric heights of points where as Global Navigation Satellite System (GNSS) provide height above ellipsoid. Thus, to make use of GNSS in engineering surveying, the relationship between ellipsoidal height and orthometric height as a function of position needs to be established through geoid modeling. In this study, an attempt has been made to develop a geoid model using the geometric method. Observations were taken in a network of sixteen stations spread over 600 km2 around Dehra Dun, India. GPS observations were taken using dual frequency geodetic GPS receivers and leveling done using digital levels with 0.1 mm accuracy. Orthometric height of stations from developed model have been found to be near to those from field levelling which is considered most accurate. Further, the values have been compared with those obtained from the recent GOCE-GRACE-LAGEOS geoid model EIGEN6C3stat. It has been found that the geometric model provides far better accuracy than that obtained from the global geoid model. Therefore, it can be concluded that the geometric method of geoid modeling can better be used for reduction of GPS observed ellipsoidal height to orthometric height in a local area. This model may gainfully be employed in a project area as a substitute for densification of leveling lines, thereby reducing the project cost substantially.

  6. Towards the development of an organisation development model for the mining industry

    OpenAIRE

    2014-01-01

    D. Litt. et Phil.(Leadership in Performance and Change) The aim of this study was to develop an organisation development model to support organisational change and transformation in a dynamic, continuously changing business environment, specifically for the mining industry in South Africa. Literature revealed that there is a tendency to employ universal and generic models to challenges of organisational change, whereas successful 00 needs a situation specific or contextualised approach. Th...

  7. Model for Simulating a Spiral Software-Development Process

    Science.gov (United States)

    Mizell, Carolyn; Curley, Charles; Nayak, Umanath

    2010-01-01

    A discrete-event simulation model, and a computer program that implements the model, have been developed as means of analyzing a spiral software-development process. This model can be tailored to specific development environments for use by software project managers in making quantitative cases for deciding among different software-development processes, courses of action, and cost estimates. A spiral process can be contrasted with a waterfall process, which is a traditional process that consists of a sequence of activities that include analysis of requirements, design, coding, testing, and support. A spiral process is an iterative process that can be regarded as a repeating modified waterfall process. Each iteration includes assessment of risk, analysis of requirements, design, coding, testing, delivery, and evaluation. A key difference between a spiral and a waterfall process is that a spiral process can accommodate changes in requirements at each iteration, whereas in a waterfall process, requirements are considered to be fixed from the beginning and, therefore, a waterfall process is not flexible enough for some projects, especially those in which requirements are not known at the beginning or may change during development. For a given project, a spiral process may cost more and take more time than does a waterfall process, but may better satisfy a customer's expectations and needs. Models for simulating various waterfall processes have been developed previously, but until now, there have been no models for simulating spiral processes. The present spiral-process-simulating model and the software that implements it were developed by extending a discrete-event simulation process model of the IEEE 12207 Software Development Process, which was built using commercially available software known as the Process Analysis Tradeoff Tool (PATT). Typical inputs to PATT models include industry-average values of product size (expressed as number of lines of code

  8. DEVELOPMENT OF POLITICAL PARTIES AND PARTY FUNDING: MODELS AND CHARACTERISTICS

    Directory of Open Access Journals (Sweden)

    Hrvoje MATAKOVIC

    2015-03-01

    Full Text Available The first modern political parties were formed at the end of the 18th century and have, from those times up to now, undergone 4 developing phases; each of the phases is bound to ideal-type political party model: cadre parties, mass parties, catch-all parties and cartel parties. Each of these party models differentiates in various characteristics: party foundation, number of members, and way of leading the election campaigns, but also in ways of financing. This paper describes the above mentioned 4 phases of political parties’ development and 4 phases of parties' finances development; it will be analysed in detail positive and negative sides of each of the models of party financing.

  9. Development of a Bayesian Belief Network Runway Incursion Model

    Science.gov (United States)

    Green, Lawrence L.

    2014-01-01

    In a previous paper, a statistical analysis of runway incursion (RI) events was conducted to ascertain their relevance to the top ten Technical Challenges (TC) of the National Aeronautics and Space Administration (NASA) Aviation Safety Program (AvSP). The study revealed connections to perhaps several of the AvSP top ten TC. That data also identified several primary causes and contributing factors for RI events that served as the basis for developing a system-level Bayesian Belief Network (BBN) model for RI events. The system-level BBN model will allow NASA to generically model the causes of RI events and to assess the effectiveness of technology products being developed under NASA funding. These products are intended to reduce the frequency of RI events in particular, and to improve runway safety in general. The development, structure and assessment of that BBN for RI events by a Subject Matter Expert panel are documented in this paper.

  10. Task Models in the Context of User Interface Development

    Science.gov (United States)

    Szwillus, Gerd

    Task models are widely used in the field of user interface development. They represent a human actor's performance or the co-operation of a group of people on or together with a system. For considerable time, it was an open problem in the field how to switch from the analyzing step of task analysis and modeling to the synthesizing step of user interface design. In the meantime, interesting approaches have shown up dealing with this problem and helping to bridge the gap between task modeling and user interface development. In this chapter, some of these approaches are discussed, together with recent concepts used to improve the usability of user interfaces based upon underlying task models.

  11. Development of an electrical model for integrated magnetic inductors

    Directory of Open Access Journals (Sweden)

    Bechir M.B.

    2014-07-01

    Full Text Available Nowadays, the current trend consists in the development of new technologies with the aim of reducing volume, weight as well as production cost. With the aim of decreasing occupied component area, it will be interesting to use magnetic materials to confine the fields. Therefore, our works concern the modelling and the characterization of magnetic planar inductors. The proposed model is detailed for inductors fabricated with one magnetic layer. The model can take into account, the capacitance between turns and the capacitance between the last turn and the ground plane, the magnetic permeability, the skin and proximity effects of the conductors according to the frequency. The structure of optimization developed to extract the parameters of the model will be presented. Results of extracted parameters are compared with the simulation parameters. A good correlation is observed on Y11 and Y12 parameters on all the broad band frequency.

  12. Wake models developed during the Wind Shadow project

    Energy Technology Data Exchange (ETDEWEB)

    Larsen, S.; Ott, S.; Pena, A.; Berg, J.; Nielsen, M.; Rathmann, O.; Joergensen, H.

    2011-11-15

    The Wind Shadow project has developed and validated improved models for determining the wakes losses, and thereby the array efficiency of very large, closely packed wind farms. The rationale behind the project has been that the existing software has been covering these types of wind farms poorly, both with respect to the densely packed turbines and the large fetches needed to describe the collective shadow effects of one farm to the next. Further the project has developed the necessary software for the use of the models. Guidelines with recommendations for the use of the models are included in the model deliverables. The project has been carried out as a collaborative project between Risoe DTU, DONG, Vattenfall, DNV and VESTAS, and it has been financed by energinet.dk grant no. 10086. (Author)

  13. A Model for Effective Professional Development of Formal Science Educators

    Science.gov (United States)

    Bleacher, L. V.; Jones, A. J. P.; Farrell, W. M.

    2015-01-01

    The Lunar Workshops for Educators (LWE) series was developed by the Lunar Reconnaissance Orbiter (LRO) education team in 2010 to provide professional development on lunar science and exploration concepts for grades 6-9 science teachers. Over 300 educators have been trained to date. The LWE model incorporates best practices from pedagogical research of science education, thoughtful integration of scientists and engineer subject matter experts for both content presentations and informal networking with educators, access to NASA-unique facilities, hands-on and data-rich activities aligned with education standards, exposure to the practice of science, tools for addressing common misconceptions, follow-up with participants, and extensive evaluation. Evaluation of the LWE model via pre- and post-assessments, daily workshop surveys, and follow-up surveys at 6-month and 1-year intervals indicate that the LWE are extremely effective in increasing educators' content knowledge, confidence in incorporating content into the classroom, understanding of the practice of science, and ability to address common student misconceptions. In order to address the efficacy of the LWE model for other science content areas, the Dynamic Response of Environments at Asteroids, the Moon, and moons of Mars (DREAM2) education team, funded by NASA's Solar System Exploration Research Virtual Institute, developed and ran a pilot workshop called Dream2Explore at NASA's Goddard Space Flight Center in June, 2015. Dream2Explore utilized the LWE model, but incorporated content related to the science and exploration of asteroids and the moons of Mars. Evaluation results indicate that the LWE model was effectively used for educator professional development on non-lunar content. We will present more detail on the LWE model, evaluation results from the Dream2Explore pilot workshop, and suggestions for the application of the model with other science content for robust educator professional development.

  14. A Model for Effective Professional Development of Formal Science Educators

    Science.gov (United States)

    Bleacher, L.; Jones, A. P.; Farrell, W. M.

    2015-12-01

    The Lunar Workshops for Educators (LWE) series was developed by the Lunar Reconnaissance Orbiter (LRO) education team in 2010 to provide professional development on lunar science and exploration concepts for grades 6-9 science teachers. Over 300 educators have been trained to date. The LWE model incorporates best practices from pedagogical research of science education, thoughtful integration of scientists and engineer subject matter experts for both content presentations and informal networking with educators, access to NASA-unique facilities, hands-on and data-rich activities aligned with education standards, exposure to the practice of science, tools for addressing common misconceptions, follow-up with participants, and extensive evaluation. Evaluation of the LWE model via pre- and post-assessments, daily workshop surveys, and follow-up surveys at 6-month and 1-year intervals indicate that the LWE are extremely effective in increasing educators' content knowledge, confidence in incorporating content into the classroom, understanding of the practice of science, and ability to address common student misconceptions. In order to address the efficacy of the LWE model for other science content areas, the Dynamic Response of Environments at Asteroids, the Moon, and moons of Mars (DREAM2) education team, funded by NASA's Solar System Exploration Research Virtual Institute, developed and ran a pilot workshop called Dream2Explore at NASA's Goddard Space Flight Center in June, 2015. Dream2Explore utilized the LWE model, but incorporated content related to the science and exploration of asteroids and the moons of Mars. Evaluation results indicate that the LWE model was effectively used for educator professional development on non-lunar content. We will present more detail on the LWE model, evaluation results from the Dream2Explore pilot workshop, and suggestions for the application of the model with other science content for robust educator professional development.

  15. Conceptual development: an adaptive resonance theory model of polysemy

    Science.gov (United States)

    Dunbar, George L.

    1997-04-01

    Adaptive Resonance Theory provides a model of pattern classification that addresses the plasticity--stability dilemma and allows a neural network to detect when to construct a new category without the assistance of a supervisor. We show that Adaptive Resonance Theory can be applied to the study of natural concept development. Specifically, a model is presented which is able to categorize different usages of a common noun and group the polysemous senses appropriately.

  16. Developing Generic Dynamic Models for the 2030 Eastern Interconnection Grid

    Energy Technology Data Exchange (ETDEWEB)

    Kou, Gefei [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Hadley, Stanton W. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Markham, Penn N. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Liu, Yilu [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2013-12-01

    The Eastern Interconnection Planning Collaborative (EIPC) has built three major power flow cases for the 2030 Eastern Interconnection (EI) based on various levels of energy/environmental policy conditions, technology advances, and load growth. Using the power flow cases, this report documents the process of developing the generic 2030 dynamic models using typical dynamic parameters. The constructed model was validated indirectly using the synchronized phasor measurements by removing the wind generation temporarily.

  17. The Development of an Intelligent Leadership Model for State Universities

    OpenAIRE

    Aleme Keikha; Reza Hoveida; Nour Mohammad Yaghoubi

    2017-01-01

    Higher education and intelligent leadership are considered important parts of every country’s education system, which could potentially play a key role in accomplishing the goals of society. In theories of leadership, new patterns attempt to view leadership through the prism of creative and intelligent phenomena. This paper aims to design and develop an intelligent leadership model for public universities. A qualitativequantitative research method was used to design a basic model of intellige...

  18. Modeling of project management information platform of port infrastructure development

    Directory of Open Access Journals (Sweden)

    Юрій Миколайович Харитонов

    2017-01-01

    Full Text Available The problems of information support of projects and programs of port infrastructure development are defined. Corresponding information platforms of technical, technological, economic and organizational nature are proposed. Each information platform provides as an information model that includes the frames that describe the structural and parametric characteristics of the objects, as well as the set of models that address the problem of project management

  19. Development of an Ingestion Pathway Model for AXAIRQ

    Energy Technology Data Exchange (ETDEWEB)

    Simpkins, A.A.

    1999-01-13

    AXAIRQ is a dose mode code used for prospective accident assessment at the Savannah River Site and is primarily used to show regulatory compliance. For completeness of pathway analysis, an ingestion model, AXINGST, has been developed for use with, and incorporation in, AXAIRQ. Currently available ingestion models were referenced as a basis for AXINGST. AXINGST calculates a conservative ingestion dose following an atmospheric release of radionuclides and includes site specific variables where applicable.

  20. Requirements and Problems in Parallel Model Development at DWD

    Directory of Open Access Journals (Sweden)

    Ulrich Schäattler

    2000-01-01

    Full Text Available Nearly 30 years after introducing the first computer model for weather forecasting, the Deutscher Wetterdienst (DWD is developing the 4th generation of its numerical weather prediction (NWP system. It consists of a global grid point model (GME based on a triangular grid and a non-hydrostatic Lokal Modell (LM. The operational demand for running this new system is immense and can only be met by parallel computers. From the experience gained in developing earlier NWP models, several new problems had to be taken into account during the design phase of the system. Most important were portability (including efficieny of the programs on several computer architectures and ease of code maintainability. Also the organization and administration of the work done by developers from different teams and institutions is more complex than it used to be. This paper describes the models and gives some performance results. The modular approach used for the design of the LM is explained and the effects on the development are discussed.

  1. Computable general equilibrium model fiscal year 2013 capability development report

    Energy Technology Data Exchange (ETDEWEB)

    Edwards, Brian Keith [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Rivera, Michael Kelly [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Boero, Riccardo [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-05-17

    This report documents progress made on continued developments of the National Infrastructure Simulation and Analysis Center (NISAC) Computable General Equilibrium Model (NCGEM), developed in fiscal year 2012. In fiscal year 2013, NISAC the treatment of the labor market and tests performed with the model to examine the properties of the solutions computed by the model. To examine these, developers conducted a series of 20 simulations for 20 U.S. States. Each of these simulations compared an economic baseline simulation with an alternative simulation that assumed a 20-percent reduction in overall factor productivity in the manufacturing industries of each State. Differences in the simulation results between the baseline and alternative simulations capture the economic impact of the reduction in factor productivity. While not every State is affected in precisely the same way, the reduction in manufacturing industry productivity negatively affects the manufacturing industries in each State to an extent proportional to the reduction in overall factor productivity. Moreover, overall economic activity decreases when manufacturing sector productivity is reduced. Developers ran two additional simulations: (1) a version of the model for the State of Michigan, with manufacturing divided into two sub-industries (automobile and other vehicle manufacturing as one sub-industry and the rest of manufacturing as the other subindustry); and (2) a version of the model for the United States, divided into 30 industries. NISAC conducted these simulations to illustrate the flexibility of industry definitions in NCGEM and to examine the simulation properties of in more detail.

  2. Development of a fault test experimental facility model using Matlab

    Energy Technology Data Exchange (ETDEWEB)

    Pereira, Iraci Martinez; Moraes, Davi Almeida, E-mail: martinez@ipen.br, E-mail: dmoraes@dk8.com.br [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2015-07-01

    The Fault Test Experimental Facility was developed to simulate a PWR nuclear power plant and is instrumented with temperature, level and pressure sensors. The Fault Test Experimental Facility can be operated to generate normal and fault data, and these failures can be added initially small, and their magnitude being increasing gradually. This work presents the Fault Test Experimental Facility model developed using the Matlab GUIDE (Graphical User Interface Development Environment) toolbox that consists of a set of functions designed to create interfaces in an easy and fast way. The system model is based on the mass and energy inventory balance equations. Physical as well as operational aspects are taken into consideration. The interface layout looks like a process flowchart and the user can set the input variables. Besides the normal operation conditions, there is the possibility to choose a faulty variable from a list. The program also allows the user to set the noise level for the input variables. Using the model, data were generated for different operational conditions, both under normal and fault conditions with different noise levels added to the input variables. Data generated by the model will be compared with Fault Test Experimental Facility data. The Fault Test Experimental Facility theoretical model results will be used for the development of a Monitoring and Fault Detection System. (author)

  3. Cytomegalovirus Antivirals and Development of Improved Animal Models

    Science.gov (United States)

    McGregor, Alistair; Choi, K. Yeon

    2015-01-01

    Introduction Cytomegalovirus (CMV) is a ubiquitous pathogen that establishes a life long asymptomatic infection in healthy individuals. Infection of immunesuppressed individuals causes serious illness. Transplant and AIDS patients are highly susceptible to CMV leading to life threatening end organ disease. Another vulnerable population is the developing fetus in utero, where congenital infection can result in surviving newborns with long term developmental problems. There is no vaccine licensed for CMV and current antivirals suffer from complications associated with prolonged treatment. These include drug toxicity and emergence of resistant strains. There is an obvious need for new antivirals. Candidate intervention strategies are tested in controlled pre-clinical animal models but species specificity of HCMV precludes the direct study of the virus in an animal model. Areas covered This review explores the current status of CMV antivirals and development of new drugs. This includes the use of animal models and the development of new improved models such as humanized animal CMV and bioluminescent imaging of virus in animals in real time. Expert Opinion Various new CMV antivirals are in development, some with greater spectrum of activity against other viruses. Although the greatest need is in the setting of transplant patients there remains an unmet need for a safe antiviral strategy against congenital CMV. This is especially important since an effective CMV vaccine remains an elusive goal. In this capacity greater emphasis should be placed on suitable pre-clinical animal models and greater collaboration between industry and academia. PMID:21883024

  4. SpaceWire model development technology for satellite architecture.

    Energy Technology Data Exchange (ETDEWEB)

    Eldridge, John M.; Leemaster, Jacob Edward; Van Leeuwen, Brian P.

    2011-09-01

    Packet switched data communications networks that use distributed processing architectures have the potential to simplify the design and development of new, increasingly more sophisticated satellite payloads. In addition, the use of reconfigurable logic may reduce the amount of redundant hardware required in space-based applications without sacrificing reliability. These concepts were studied using software modeling and simulation, and the results are presented in this report. Models of the commercially available, packet switched data interconnect SpaceWire protocol were developed and used to create network simulations of data networks containing reconfigurable logic with traffic flows for timing system distribution.

  5. Results From Development of Model Specifications for Multifamily Energy Retrofits

    Energy Technology Data Exchange (ETDEWEB)

    Brozyna, Kevin [IBACOS, Inc., Pittsburgh, PA (United States)

    2012-08-01

    Specifications, modeled after CSI MasterFormat, provide the trade contractors and builders with requirements and recommendations on specific building materials, components and industry practices that comply with the expectations and intent of the requirements within the various funding programs associated with a project. The goal is to create a greater level of consistency in execution of energy efficiency retrofits measures across the multiple regions a developer may work. IBACOS and Mercy Housing developed sample model specifications based on a common building construction type that Mercy Housing encounters.

  6. Results from Development of Model Specifications for Multifamily Energy Retrofits

    Energy Technology Data Exchange (ETDEWEB)

    Brozyna, K.

    2012-08-01

    Specifications, modeled after CSI MasterFormat, provide the trade contractors and builders with requirements and recommendations on specific building materials, components and industry practices that comply with the expectations and intent of the requirements within the various funding programs associated with a project. The goal is to create a greater level of consistency in execution of energy efficiency retrofits measures across the multiple regions a developer may work. IBACOS and Mercy Housing developed sample model specifications based on a common building construction type that Mercy Housing encounters.

  7. A TRANSFERABLE MODEL FOR INNOVATIVE JOINT POSTGRADUATE DEGREE PROGRAMME DEVELOPMENT

    DEFF Research Database (Denmark)

    Maclachlan, Ross; Ion, William; Kochanowska, Rowena

    2009-01-01

    . The collaboration brings depth and breadth to the innovation curriculum, and the student experience, through student mobility and the complementary expertise of partners. However, for higher education institutions to effectively collaborate at both administrative and academic levels, a number of new challenges must...... be overcome. This paper reflects on specific challenges met during development of the GIM programme and presents a programme model addressing these. The model is presented as transferable to other consortia and as basis for a set of tentative principles for joint programme development with particular...

  8. The Development of Message-Design Model in Blended Learning

    Directory of Open Access Journals (Sweden)

    Ulfia Rahmi

    2017-06-01

    Full Text Available Abstract. The researcher found a problem in designing an instruction often ignore the message design because it is focused on syntax and learning systems, including the design of innovative learning such as e-learning, online learning, blended learning and mobile learning. Based on these problems, the researcher develops a model of design message in blended learning. The goal is to help the educators to facilitate learners to interpret and construct teaching materials. The development used ADDIE models. Qualitative and quantitative data were collected through observation, interviews, questionnaires, and tests in order to produce a model of message design. The validity of this products was tested by expert and the practicality and effectivity testing by the user in the course of Theory of Learning and instruction. The result of this development consists of (1 the book of model design messages in blended learning, and (2 the learning tool that consists of teaching materials, media presentations, e-learning, syllabus, SAP that is valid, practical and effective. The Book model can be used by designers of instruction, learning consultant, and lecturer/educator in helping learners to interpret and construct learning message so that they have an ability to generalize the learning and become independent learners. Keyword: Blended learning, online learning, message design, learning theory, ADDIE model

  9. Developing an Empirical Model for Jet-Surface Interaction Noise

    Science.gov (United States)

    Brown, Clifford A.

    2014-01-01

    The process of developing an empirical model for jet-surface interaction noise is described and the resulting model evaluated. Jet-surface interaction noise is generated when the high-speed engine exhaust from modern tightly integrated or conventional high-bypass ratio engine aircraft strikes or flows over the airframe surfaces. An empirical model based on an existing experimental database is developed for use in preliminary design system level studies where computation speed and range of configurations is valued over absolute accuracy to select the most promising (or eliminate the worst) possible designs. The model developed assumes that the jet-surface interaction noise spectra can be separated from the jet mixing noise and described as a parabolic function with three coefficients: peak amplitude, spectral width, and peak frequency. These coefficients are fit to functions of surface length and distance from the jet lipline to form a characteristic spectra which is then adjusted for changes in jet velocity and/or observer angle using scaling laws from published theoretical and experimental work. The resulting model is then evaluated for its ability to reproduce the characteristic spectra and then for reproducing spectra measured at other jet velocities and observer angles; successes and limitations are discussed considering the complexity of the jet-surface interaction noise versus the desire for a model that is simple to implement and quick to execute.

  10. Drug discovery and development for neglected diseases: the DNDi model.

    Science.gov (United States)

    Chatelain, Eric; Ioset, Jean-Robert

    2011-03-16

    New models of drug discovery have been developed to overcome the lack of modern and effective drugs for neglected diseases such as human African trypanosomiasis (HAT; sleeping sickness), leishmaniasis, and Chagas disease, which have no financial viability for the pharmaceutical industry. With the purpose of combining the skills and research capacity in academia, pharmaceutical industry, and contract researchers, public-private partnerships or product development partnerships aim to create focused research consortia that address all aspects of drug discovery and development. These consortia not only emulate the projects within pharmaceutical and biotechnology industries, eg, identification and screening of libraries, medicinal chemistry, pharmacology and pharmacodynamics, formulation development, and manufacturing, but also use and strengthen existing capacity in disease-endemic countries, particularly for the conduct of clinical trials. The Drugs for Neglected Diseases initiative (DNDi) has adopted a model closely related to that of a virtual biotechnology company for the identification and optimization of drug leads. The application of this model to the development of drug candidates for the kinetoplastid infections of HAT, Chagas disease, and leishmaniasis has already led to the identification of new candidates issued from DNDi's own discovery pipeline. This demonstrates that the model DNDi has been implementing is working but its DNDi, neglected diseases sustainability remains to be proven.

  11. Archetype Model-Driven Development Framework for EHR Web System.

    Science.gov (United States)

    Kobayashi, Shinji; Kimura, Eizen; Ishihara, Ken

    2013-12-01

    This article describes the Web application framework for Electronic Health Records (EHRs) we have developed to reduce construction costs for EHR sytems. The openEHR project has developed clinical model driven architecture for future-proof interoperable EHR systems. This project provides the specifications to standardize clinical domain model implementations, upon which the ISO/CEN 13606 standards are based. The reference implementation has been formally described in Eiffel. Moreover C# and Java implementations have been developed as reference. While scripting languages had been more popular because of their higher efficiency and faster development in recent years, they had not been involved in the openEHR implementations. From 2007, we have used the Ruby language and Ruby on Rails (RoR) as an agile development platform to implement EHR systems, which is in conformity with the openEHR specifications. We implemented almost all of the specifications, the Archetype Definition Language parser, and RoR scaffold generator from archetype. Although some problems have emerged, most of them have been resolved. We have provided an agile EHR Web framework, which can build up Web systems from archetype models using RoR. The feasibility of the archetype model to provide semantic interoperability of EHRs has been demonstrated and we have verified that that it is suitable for the construction of EHR systems.

  12. Developing Experimental Models for NASA Missions with ASSL

    Directory of Open Access Journals (Sweden)

    Emil Vassev

    2010-03-01

    Full Text Available NASA's new age of space exploration augurs great promise for deep space exploration missions whereby spacecraft should be independent, autonomous, and smart. Nowadays NASA increasingly relies on the concepts of autonomic computing, exploiting these to increase the survivability of remote missions, particularly when human tending is not feasible. Autonomic computing has been recognized as a promising approach for the development of self-managing spacecraft systems that employ onboard intelligence and rely less on control links. The Autonomic System Specification Language (ASSL is a framework for formally specifying and generating autonomic systems. As part of long-term research targeted at the development of models for space exploration missions that rely on principles of autonomic computing, we have employed ASSL to develop formal models and generate functional prototypes for NASA missions. This helps to validate features and perform experiments through simulation. Here, we discuss our work on developing such missions with ASSL.

  13. [Development of a peristaltic inhibition model in mice].

    Science.gov (United States)

    Cui, S; Li, Y; Li, Y; Han, C

    2000-11-01

    Diphenoxylate was administered to mice at the dose of 5 mg/kg BW for the development of peristaltic inhibition model for formulating the examination procedure of health foods. An ink solution containing 5% charcoal was then administered 30 minutes later. The length of ink progradation of the small intestine of mice was calculated 25 minutes after the administration of ink. The results in this model was stable and reliable, and it was recommended to use this model to verify the function of health foods.

  14. Computable general equilibrium model fiscal year 2014 capability development report

    Energy Technology Data Exchange (ETDEWEB)

    Edwards, Brian Keith [Los Alamos National Laboratory; Boero, Riccardo [Los Alamos National Laboratory

    2016-05-11

    This report provides an overview of the development of the NISAC CGE economic modeling capability since 2012. This capability enhances NISAC's economic modeling and analysis capabilities to answer a broader set of questions than possible with previous economic analysis capability. In particular, CGE modeling captures how the different sectors of the economy, for example, households, businesses, government, etc., interact to allocate resources in an economy and this approach captures these interactions when it is used to estimate the economic impacts of the kinds of events NISAC often analyzes.

  15. Development of Improved Mechanistic Deterioration Models for Flexible Pavements

    DEFF Research Database (Denmark)

    Ullidtz, Per; Ertman, Hans Larsen

    1998-01-01

    The paper describes a pilot study in Denmark with the main objective of developing improved mechanistic deterioration models for flexible pavements based on an accelerated full scale test on an instrumented pavement in the Danish Road Tessting Machine. The study was the first in "International...... Pavement Subgrade Performance Study" sponsored by the Federal Highway Administration (FHWA), USA. The paper describes in detail the data analysis and the resulting models for rutting, roughness, and a model for the plastic strain in the subgrade.The reader will get an understanding of the work needed...

  16. Recontextualizing Psychosocial Development in Young Children: A Model of Environmental Identity Development

    Science.gov (United States)

    Green, Carie; Kalvaitis, Darius; Worster, Anneliese

    2016-01-01

    This article presents an Environmental Identity Development model, which considers the progression of young children's self-cognitions in relation to the natural world. We recontextualize four of Erikson's psychosocial stages, in order to consider children's identity development in learning in, about, and for the environment. Beginning with…

  17. Fieldwork Using the Professional Development Schools Model: Developing a Social Justice Orientation and Multicultural Competency

    Science.gov (United States)

    Cook, Amy L.; Krell, Megan M.; Hayden, Laura A.; Gracia, Robert; Denitzio, Kari

    2016-01-01

    Practicum fieldwork was conducted in an urban high school setting using a Professional Development Schools (PDS) model, with a focus on multicultural and social justice counseling competencies (MSJCC). Interpretative phenomenological analysis was used to analyze the journal responses of 16 counseling students to ascertain MSJCC development during…

  18. Development of the transformational advanced professional practice model.

    Science.gov (United States)

    Elliott, Elizabeth C; Walden, Marlene

    2015-09-01

    The purpose of this article is to describe the development of a professional practice model (PPM) for advanced practice registered nurses (APRNs). A literature review was conducted on PPMs. Simultaneous review of authoritative resources, including The National Organization of Nurse Practitioner Faculties (NONPF) and the Licensure, Accreditation, Certification and Education (LACE) Consensus Model, was performed. An expert panel was established to validate the transformational advanced professional practice (TAPP) model. APRNs are relied upon by organizations to provide leadership in the delivery of high-quality, cost-effective health care while improving access and eliminating preventable morbidities. Existing models fail to fully capture the professional scope of practice for APRNs. The TAPP model serves as a framework to guide professional development and mentorship of APRNs in seven domains of professional practice (DOPP). To meet the Institute of Medicine's recommendations for the future of nursing, APRNs should practice to the fullest extent of their education and training. Providing clarification regarding the DOPP of the APRN role is needed to standardized professional practice. The TAPP model is an inspiring blueprint that allows APRNs to model the way by delivering comprehensive health care in seven DOPP. ©2015 American Association of Nurse Practitioners.

  19. Network Models of Entrepreneurial Ecosystems in Developing Economies

    Science.gov (United States)

    2014-01-01

    interesting insights: • The Military and Religion Roles have no impact on this ecosystem . • The Self (an entrepreneur can access the necessary resources...Technical Report 15-004 Network Models of Entrepreneurial Ecosystems in Developing Economies Daniel Evans Louis Boguchwal...Entrepreneurial Ecosystems in Developing Economies 5b. GRANT NUMBER n/a 5c. PROGRAM ELEMENT NUMBER n/a 6. AUTHOR(S) Daniel Evans and Louis

  20. Did China follow the East Asian development model?

    OpenAIRE

    Boltho, Andrea; Weber, Maria

    2009-01-01

    China is located in East Asia and, just as Japan, Taiwan or (South) Korea at earlier stages of their development, has now grown very rapidly for some three decades. That is not enough, however, for it to qualify for membership of the club. The East Asian development model has a number of additional and important characteristics. Four are selected for discussion: the almost constant encouragement given to investment, the manufacturing sector and external competitiveness, and pursued via a vari...

  1. Development of an Integrated Nonlinear Aeroservoelastic Flight Dynamic Model of the NASA Generic Transport Model

    Science.gov (United States)

    Nguyen, Nhan; Ting, Eric

    2018-01-01

    This paper describes a recent development of an integrated fully coupled aeroservoelastic flight dynamic model of the NASA Generic Transport Model (GTM). The integrated model couples nonlinear flight dynamics to a nonlinear aeroelastic model of the GTM. The nonlinearity includes the coupling of the rigid-body aircraft states in the partial derivatives of the aeroelastic angle of attack. Aeroservoelastic modeling of the control surfaces which are modeled by the Variable Camber Continuous Trailing Edge Flap is also conducted. The R.T. Jones' method is implemented to approximate unsteady aerodynamics. Simulations of the GTM are conducted with simulated continuous and discrete gust loads..

  2. Developing natural resource models using the object modeling system: feasibility and challenges

    Directory of Open Access Journals (Sweden)

    L. R. Ahuja

    2005-01-01

    Full Text Available Current challenges in natural resource management have created demand for integrated, flexible, and easily parameterized hydrologic models. Most of these monolithic models are not modular, thus modifications (e.g., changes in process representation require considerable time, effort, and expense. In this paper, the feasibility and challenges of using the Object Modeling System (OMS for natural resource model development will be explored. The OMS is a Java-based modeling framework that facilitates simulation model development, evaluation, and deployment. In general, the OMS consists of a library of science, control, and database modules and a means to assemble the selected modules into an application-specific modeling package. The framework is supported by data dictionary, data retrieval, GIS, graphical visualization, and statistical analysis utility modules. Specific features of the OMS that will be discussed include: 1 how to reduce duplication of effort in natural resource modeling; 2 how to make natural resource models easier to build, apply, and evaluate; 3 how to facilitate long-term maintainability of existing and new natural resource models; and 4 how to improve the quality of natural resource model code and ensure credibility of model implementations. Examples of integrating a simple water balance model and a large monolithic model into the OMS will be presented.

  3. Using cognitive models to develop quality multiple-choice questions.

    Science.gov (United States)

    Pugh, Debra; De Champlain, Andre; Gierl, Mark; Lai, Hollis; Touchie, Claire

    2016-08-01

    With the recent interest in competency-based education, educators are being challenged to develop more assessment opportunities. As such, there is increased demand for exam content development, which can be a very labor-intense process. An innovative solution to this challenge has been the use of automatic item generation (AIG) to develop multiple-choice questions (MCQs). In AIG, computer technology is used to generate test items from cognitive models (i.e. representations of the knowledge and skills that are required to solve a problem). The main advantage yielded by AIG is the efficiency in generating items. Although technology for AIG relies on a linear programming approach, the same principles can also be used to improve traditional committee-based processes used in the development of MCQs. Using this approach, content experts deconstruct their clinical reasoning process to develop a cognitive model which, in turn, is used to create MCQs. This approach is appealing because it: (1) is efficient; (2) has been shown to produce items with psychometric properties comparable to those generated using a traditional approach; and (3) can be used to assess higher order skills (i.e. application of knowledge). The purpose of this article is to provide a novel framework for the development of high-quality MCQs using cognitive models.

  4. Model-based development of neuroprosthesis for paraplegic patients.

    Science.gov (United States)

    Riener, R

    1999-01-01

    In paraplegic patients with upper motor neuron lesions the signal path from the central nervous system to the muscles is interrupted. Functional electrical stimulation applied to the lower motor neurons can replace the lacking signals. A so-called neuroprosthesis may be used to restore motor function in paraplegic patients on the basis of functional electrical stimulation. However, the control of multiple joints is difficult due to the complexity, nonlinearity, and time-variance of the system involved. Furthermore, effects such as muscle fatigue, spasticity, and limited force in the stimulated muscle further complicate the control task. Mathematical models of the human musculoskeletal system can support the development of neuroprosthesis. In this article a detailed overview of the existing work in the literature is given and two examples developed by the author are presented that give an insight into model-based development of neuroprosthesis for paraplegic patients. It is shown that modelling the musculoskeletal system can provide better understanding of muscular force production and movement coordination principles. Models can also be used to design and test stimulation patterns and feedback control strategies. Additionally, model components can be implemented in a controller to improve control performance. Eventually, the use of musculoskeletal models for neuroprosthesis design may help to avoid internal disturbances such as fatigue and optimize muscular force output. Furthermore, better controller quality can be obtained than in previous empirical approaches. In addition, the number of experimental tests to be performed with human subjects can be reduced. It is concluded that mathematical models play an increasing role in the development of reliable closed-loop controlled, lower extremity neuroprostheses. PMID:10382222

  5. ICFD modeling of final settlers - developing consistent and effective simulation model structures

    DEFF Research Database (Denmark)

    Plósz, Benedek G.; Guyonvarch, Estelle; Ramin, Elham

    Summary of key findings The concept of interpreted computational fluid dynamic (iCFD) modelling and the development methodology are presented (Fig. 1). The 1-D advection-dispersion model along with the statistically generated, meta-model for pseudo-dispersion constitutes the newly developed i...... for the SST through the proposed methodology is able to predict solid distribution with high accuracy -- taking a reasonable computational effort -- when compared to multi-dimensional numerical experiments, under a wide range of flow and design conditions. The iCFD models developed are intended to comply...... with the consistent modelling methodology (1). iCFD tools could play an important role in reliably predicting WWTP performance under normal and shock-loading (7). Background and relevance System analysis tools typically comprise numerous sub-models, identified so that the computational effort taken through system...

  6. Experimental development based on mapping rule between requirements analysis model and web framework specific design model.

    Science.gov (United States)

    Okuda, Hirotaka; Ogata, Shinpei; Matsuura, Saeko

    2013-12-01

    Model Driven Development is a promising approach to develop high quality software systems. We have proposed a method of model-driven requirements analysis using Unified Modeling Language (UML). The main feature of our method is to automatically generate a Web user interface prototype from UML requirements analysis model so that we can confirm validity of input/output data for each page and page transition on the system by directly operating the prototype. We proposes a mapping rule in which design information independent of each web application framework implementation is defined based on the requirements analysis model, so as to improve the traceability to the final product from the valid requirements analysis model. This paper discusses the result of applying our method to the development of a Group Work Support System that is currently running in our department.

  7. Brookhaven Regional Energy Facility Siting Model (REFS): model development and application

    Energy Technology Data Exchange (ETDEWEB)

    Meier, P.; Hobbs, B.; Ketcham, G.; McCoy, M.; Stern, R.

    1979-06-01

    A siting methodology developed specifically to bridge the gap between regional-energy-system scenarios and environmental transport models is documented. Development of the model is described in Chapter 1. Chapter 2 described the basic structure of such a model. Additional chapters on model development cover: generation, transmission, demand disaggregation, the interface to other models, computational aspects, the coal sector, water resource considerations, and air quality considerations. These subjects comprise Part I. Part II, Model Applications, covers: analysis of water resource constraints, water resource issues in the New York Power Pool, water resource issues in the New England Power Pool, water resource issues in the Pennsylvania-Jersey-Maryland Power Pool, and a summary of water resource constraint analysis. (MCW)

  8. [Development and verification of Chinese dietary exposure evaluation model software].

    Science.gov (United States)

    Liu, Pei; Li, Jing-xin; Sun, Jin-fang; Xue, Jianping; Chen, Bing-wei; Zhang, Hong; Yu, Xiao-jin; Wang, Can-nan; Yuan, Bao-jun; Ma, Yong-jian; Tian, Zi-hua

    2010-03-01

    To develop the dietary exposure evaluation model software accredited of Chinese intellectual property rights and to verify the rationality and accuracy of the results from the probabilistic model in Chinese dietary exposure evaluation model software according to international standards. The software of SAS was used to build various evaluation model based on the data from Chinese dietary survey and the chemical compound in food surveillance and to design an operation interface. The results from probabilistic dietary exposure model for children 2 - 7 years old were compared with that from duplicate portion study of 2-7 years children dietary exposure in Jinhu, Jiangsu province in order to analyze the rationality of model. The results from probabilistic model of dietary exposure were compared with the results from @Risk software to verify the correction of the probabilistic model by using the same data of randomly selected 10 000 study subjects from national dietary survey. While, the mean drift was used as an internal index to illustrate the accuracy of the computation. Chinese dietary exposure evaluation software was developed successfully. On the rationality, the results from probabilistic model were lower than that from the point estimation (e.g., cucumber: the result of point estimation of acephate was 4.78 microg x kg(-1) x d(-1), while the results of probabilistic model which was 0.39 microg x kg(-1) x d(-1)). Meanwhile the results from probabilistic model were higher than the results of duplicate portion study (on the P95, the result of probabilistic model of Pb exposure in children was 11.08 microg x kg(-1) x d(-1), while the results of duplicate portion study was 5.75 microg x kg(-1) x d(-1)). On accuracy, the results from @Risk and the probabilistic model were highly consistent (on the P95, the result of probabilistic assessment of acephate diet exposure was 4.27 microg x kg(-1) x d(-1), while the results of duplicate portion study was 4.24 microg x kg(-1

  9. Innovative model of development of traditionally industrial territories

    Directory of Open Access Journals (Sweden)

    Olga Anatolyevna Kozlova

    2012-09-01

    Full Text Available The consideration in this paper is given to innovative model of development of traditionally industrial territories. We emphasize the following basic approaches to the employment of innovative potential of territories: diversification and restructuring of local economy, integration and disintegration of life-sustaining activity of neighboring territories, progressive economic advance, as well as simultaneous combination of several approaches (mixed model. Progressive model of development is sufficiently popular and is related tothe increasing already existing potential of territories. In practice,it doesn’t generally suppose essential changes in sectoral structure of local economy and means developing existing productions and spheres of activity of territory. Mixed model of structural transformations is characterized through the fact, that it supposes simultaneous use of different elements from the models counted. It allows: firstly, to adopt in a bigger extent a complex of measures to conditions of certain territory; secondly, to take into account a broader range of exogenous and endogenous factors; thirdly, to raise the effectiveness of the program of structural transformations being realized

  10. Applied economic model development algorithm for electronics company

    Directory of Open Access Journals (Sweden)

    Mikhailov I.

    2017-01-01

    Full Text Available The purpose of this paper is to report about received experience in the field of creating the actual methods and algorithms that help to simplify development of applied decision support systems. It reports about an algorithm, which is a result of two years research and have more than one-year practical verification. In a case of testing electronic components, the time of the contract conclusion is crucial point to make the greatest managerial mistake. At this stage, it is difficult to achieve a realistic assessment of time-limit and of wage-fund for future work. The creation of estimating model is possible way to solve this problem. In the article is represented an algorithm for creation of those models. The algorithm is based on example of the analytical model development that serves for amount of work estimation. The paper lists the algorithm’s stages and explains their meanings with participants’ goals. The implementation of the algorithm have made possible twofold acceleration of these models development and fulfilment of management’s requirements. The resulting models have made a significant economic effect. A new set of tasks was identified to be further theoretical study.

  11. PBPK modeling and simulation in drug research and development.

    Science.gov (United States)

    Zhuang, Xiaomei; Lu, Chuang

    2016-09-01

    Physiologically based pharmacokinetic (PBPK) modeling and simulation can be used to predict the pharmacokinetic behavior of drugs in humans using preclinical data. It can also explore the effects of various physiologic parameters such as age, ethnicity, or disease status on human pharmacokinetics, as well as guide dose and dose regiment selection and aid drug-drug interaction risk assessment. PBPK modeling has developed rapidly in the last decade within both the field of academia and the pharmaceutical industry, and has become an integral tool in drug discovery and development. In this mini-review, the concept and methodology of PBPK modeling are briefly introduced. Several case studies were discussed on how PBPK modeling and simulation can be utilized through various stages of drug discovery and development. These case studies are from our own work and the literature for better understanding of the absorption, distribution, metabolism and excretion (ADME) of a drug candidate, and the applications to increase efficiency, reduce the need for animal studies, and perhaps to replace clinical trials. The regulatory acceptance and industrial practices around PBPK modeling and simulation is also discussed.

  12. Sectoral transitions - modeling the development from agrarian to service economies

    Science.gov (United States)

    Lutz, Raphael; Spies, Michael; Reusser, Dominik E.; Kropp, Jürgen P.; Rybski, Diego

    2013-04-01

    We consider the sectoral composition of a country's GDP, i.e the partitioning into agrarian, industrial, and service sectors. Exploring a simple system of differential equations we characterise the transfer of GDP shares between the sectors in the course of economic development. The model fits for the majority of countries providing 4 country-specific parameters. Relating the agrarian with the industrial sector, a data collapse over all countries and all years supports the applicability of our approach. Depending on the parameter ranges, country development exhibits different transfer properties. Most countries follow 3 of 8 characteristic paths. The types are not random but show distinct geographic and development patterns.

  13. How to develop a phenomenological model of disability

    DEFF Research Database (Denmark)

    Martiny, Kristian Møller Moltke

    2015-01-01

    During recent decades various researchers from health and social sciences have been debating what it means for a person to be disabled. A rather overlooked approach has developed alongside this debate, primarily inspired by the philosophical tradition called phenomenology. This paper develops...... contributes to the debates about disability by further describing the personal aspects and experience of persons living with disabilities....... a phenomenological model of disability by arguing for a different methodological and conceptual framework from that used by the existing phenomenological approach. The existing approach is developed from the phenomenology of illness, but the paper illustrates how the case of congenital disabilities, looking...

  14. Computational Models of Relational Processes in Cognitive Development

    Science.gov (United States)

    Halford, Graeme S.; Andrews, Glenda; Wilson, William H.; Phillips, Steven

    2012-01-01

    Acquisition of relational knowledge is a core process in cognitive development. Relational knowledge is dynamic and flexible, entails structure-consistent mappings between representations, has properties of compositionality and systematicity, and depends on binding in working memory. We review three types of computational models relevant to…

  15. New developments in fused deposition modeling of ceramics

    DEFF Research Database (Denmark)

    Bellini, Anna; Shor, L.; Guceri, S.I.

    2005-01-01

    Purpose - To shift from rapid prototyping (RP) to agile fabrication by broadening the material selection, e.g. using ceramics, hence improving the properties (e.g. mechanical properties) of fused deposition modeling (FDM) products. Design/methodology/approach - This paper presents the development...

  16. Accessing Curriculum Through Technology Tools (ACTTT): A Model Development Project

    Science.gov (United States)

    Daytner, Katrina M.; Johanson, Joyce; Clark, Letha; Robinson, Linda

    2012-01-01

    Accessing Curriculum Through Technology Tools (ACTTT), a project funded by the U.S. Office of Special Education Programs (OSEP), developed and tested a model designed to allow children in early elementary school, including those "at risk" and with disabilities, to better access, participate in, and benefit from the general curriculum.…

  17. LG Solid Oxide Fuel Cell (SOFC) Model Development

    Energy Technology Data Exchange (ETDEWEB)

    Haberman, Ben [LG Fuel Cell Systems Inc., North Canton, OH (United States); Martinez-Baca, Carlos [LG Fuel Cell Systems Inc., North Canton, OH (United States); Rush, Greg [LG Fuel Cell Systems Inc., North Canton, OH (United States)

    2013-05-31

    This report presents a summary of the work performed by LG Fuel Cell Systems Inc. during the project LG Solid Oxide Fuel Cell (SOFC) Model Development (DOE Award Number: DE-FE0000773) which commenced on October 1, 2009 and was completed on March 31, 2013. The aim of this project is for LG Fuel Cell Systems Inc. (formerly known as Rolls-Royce Fuel Cell Systems (US) Inc.) (LGFCS) to develop a multi-physics solid oxide fuel cell (SOFC) computer code (MPC) for performance calculations of the LGFCS fuel cell structure to support fuel cell product design and development. A summary of the initial stages of the project is provided which describes the MPC requirements that were developed and the selection of a candidate code, STAR-CCM+ (CD-adapco). This is followed by a detailed description of the subsequent work program including code enhancement and model verification and validation activities. Details of the code enhancements that were implemented to facilitate MPC SOFC simulations are provided along with a description of the models that were built using the MPC and validated against experimental data. The modeling work described in this report represents a level of calculation detail that has not been previously available within LGFCS.

  18. Model Development for Auto Spare Parts Inventory Control and ...

    African Journals Online (AJOL)

    2012-12-01

    Dec 1, 2012 ... from discarded and end-of-life products can be used as a source of spare parts during post product life cycle. Therefore, they developed a simulation model of the manufacturing system and integrated a. Genetic Algorithm (GA) [17][18]19] to determine the optimal final order quantities for a number of critical ...

  19. Development of a mathematical model for managing magnitude and ...

    African Journals Online (AJOL)

    Development of a mathematical model for managing magnitude and risk factors of injuries. ... a helpful Frequently Asked Questions about PDFs. Alternatively, you can download the PDF file directly to your computer, from where it can be opened using a PDF reader. To download the PDF, click the Download link above.

  20. SUPERCRITICAL WATER OXIDATION MODEL DEVELOPMENT FOR SELECTED EPA PRIORITY POLLUTANTS

    Science.gov (United States)

    Supercritical Water Oxidation (SCWO) evaluated for five compounds: acetic acid, 2,4-dichlorophenol, pentachlorophenol, pyridine, 2,4-dichlorophenoxyacetic acid (methyl ester). inetic models were developed for acetic acid, 2,4-dichlorophenol, and pyridine. he test compounds were e...

  1. A Constructive Neural-Network Approach to Modeling Psychological Development

    Science.gov (United States)

    Shultz, Thomas R.

    2012-01-01

    This article reviews a particular computational modeling approach to the study of psychological development--that of constructive neural networks. This approach is applied to a variety of developmental domains and issues, including Piagetian tasks, shift learning, language acquisition, number comparison, habituation of visual attention, concept…

  2. Some Instructional Implications from a Mathematical Model of Cognitive Development.

    Science.gov (United States)

    Mierkiewicz, Diane B.

    Cognitive development and various educational implications are discussed in terms of Donald Saari's model of the interaction of a learner and the enviroment and the constraints imposed by the inefficiency of the learner's cognitive system. Saari proposed a hierarchical system of cognitive structures such that the relationships between structures…

  3. Models of Continuing Professional Development: A Framework for Analysis

    Science.gov (United States)

    Kennedy, Aileen

    2014-01-01

    The area of teachers' continuing professional development (CPD) is of growing interest internationally. However, while an increasing range of literature focuses on particular aspects of CPD, there is a paucity of literature addressing the spectrum of CPD models in a comparative manner. This article therefore considers a wide range of international…

  4. Soil Retaining Structures : Development of models for structural analysis

    NARCIS (Netherlands)

    Bakker, K.J.

    2000-01-01

    The topic of this thesis is the development of models for the structural analysis of soil retaining structures. The soil retaining structures being looked at are; block revetments, flexible retaining walls and bored tunnels in soft soil. Within this context typical structural behavior of these

  5. Development of a transport model for the microbial degradation of ...

    African Journals Online (AJOL)

    A mathematical model for first order reaction rate under isothermal condition was developed for predicting the diffusivity and transport rate of anthracene and pyrene during biodegradation using two microbial strains (corynebacteria spp and pseudomonas putida) in a heterogeneous porous medium. The formulation ...

  6. Development and characterization of an organotypic model of Barrett's esophagus

    NARCIS (Netherlands)

    Kosoff, Rachelle E.; Gardiner, Kristin L.; Merlo, Lauren M. F.; Pavlov, Kirill; Rustgi, Anil K.; Maley, Carlo C.

    Understanding the molecular and cellular processes underlying the development, maintenance, and progression of Barrett's esophagus (BE) presents an empirical challenge because there are no simple animal models and standard 2D cell culture can distort cellular processes. Here we describe a

  7. Business models and information systems for sustainable development

    NARCIS (Netherlands)

    van Sinderen, Marten J.; Shishkov, Boris; Shishkov, B.B.

    Businesses are expected to explore market opportunities in the area of sustainable development, thus contributing to finding solutions aiming at sustainable quality of life. This will require adaptation and innovation of business models and information systems, with challenges of particular interest

  8. A Social Development Model of Serious Delinquency: Examining Gender Differences.

    Science.gov (United States)

    Laundra, Kenneth H.; Kiger, Gary; Bahr, Stephen J.

    2002-01-01

    This study offers a critical review and analysis of the Social Development Model and social control theory in delinquency. Results show that attachment and commitment to parents, school, and peers is associated with delinquency for both boys and girls. Parental attachment and commitment play a stronger role in female delinquency, while alienation…

  9. Development of simple kinetic models and parameter estimation for ...

    African Journals Online (AJOL)

    The growth of P. pastoris on both glycerol and methanol could be represented by Monod kinetic equation. A simple simulation methodology and developed models were shown to satisfactorily describe both growth and production of recombinant human serum albumin (rHSA) using a genetically modified P. pastoris MutS ...

  10. Developing Models to Forcast Sales of Natural Christmas Trees

    Science.gov (United States)

    Lawrence D. Garrett; Thomas H. Pendleton

    1977-01-01

    A study of practices for marketing Christmas trees in Winston-Salem, North Carolina, and Denver, Colorado, revealed that such factors as retail lot competition, tree price, consumer traffic, and consumer income were very important in determining a particular retailer's sales. Analyses of 4 years of market data were used in developing regression models for...

  11. Development of a perfect prognosis probabilistic model for ...

    Indian Academy of Sciences (India)

    A prediction model based on the perfect prognosis method was developed to predict the probability of lightning and probable time of its occurrence over the south-east Indian region. In the perfect prognosis method, statistical relationships are established using past observed data. For real time applications, the predictors ...

  12. Classroom Crisis Intervention through Contracting: A Moral Development Model.

    Science.gov (United States)

    Smaby, Marlowe H.; Tamminen, Armas W.

    1981-01-01

    A counselor can arbitrate problem situations using a systematic approach to classroom intervention which includes meetings with the teacher and students. This crisis intervention model based on moral development can be more effective than reliance on guidance activities disconnected from the actual classroom settings where the problems arise.…

  13. Agency, Values, and Well-Being: A Human Development Model

    Science.gov (United States)

    Welzel, Christian; Inglehart, Ronald

    2010-01-01

    This paper argues that feelings of agency are linked to human well-being through a sequence of adaptive mechanisms that promote human development, once existential conditions become permissive. In the first part, we elaborate on the evolutionary logic of this model and outline why an evolutionary perspective is helpful to understand changes in…

  14. Model Development for Economic Replacement of Equipment in a ...

    African Journals Online (AJOL)

    Decisions on investments in a depressed economy are usually bedevilled with uncertainties as a result of galloping price changes. A sound analytical base is therefore required that will aid decisions and reduce uncertainties to the barest minimum, if not eliminate them. To this end, a model was developed for the ...

  15. Inclusion Professional Development Model and Regular Middle School Educators

    Science.gov (United States)

    Royster, Otelia; Reglin, Gary L.; Losike-Sedimo, Nonofo

    2014-01-01

    The purpose of this study was to determine the impact of a professional development model on regular education middle school teachers' knowledge of best practices for teaching inclusive classes and attitudes toward teaching these classes. There were 19 regular education teachers who taught the core subjects. Findings for Research Question 1…

  16. Models as Feedback: Developing Representational Competence in Chemistry

    Science.gov (United States)

    Padalkar, Shamin; Hegarty, Mary

    2015-01-01

    Spatial information in science is often expressed through representations such as diagrams and models. Learning the strengths and limitations of these representations and how to relate them are important aspects of developing scientific understanding, referred to as "representational competence." Diagram translation is particularly…

  17. Modeling Business Development Services (BDS) in the Tanzania ...

    African Journals Online (AJOL)

    The paper aims at proposing a model leading to finding out the determinants of successful provision of useful business development services (BDS) in Tanzania's SMEs market. To this end, the paper specifically aims to; first, examine the extent to which BDS demand side factors affect the successful provision of useful BDS.

  18. Development of a Guinea Pig Lung Deposition Model

    Science.gov (United States)

    2016-01-01

    receptors in guinea- pig lung and heart . European Journal of Pharmacology 181:51-58. Guyton, A.C. (1947). Measurement of respiratory volumes of laboratory...Development of a Guinea Pig Lung Deposition Model Distribution Statement A. Approved for public release; distribution is unlimited. January...4 Figure 2. Particle deposition in the lung of the guinea pig via endotracheal breathing

  19. Using Work Breakdown Structure Models to Develop Unit Treatment Costs

    Science.gov (United States)

    This article presents a new cost modeling approach called work breakdown structure (WBS), designed to develop unit costs for drinking water technologies. WBS involves breaking the technology into its discrete components for the purposes of estimating unit costs. The article dem...

  20. Simple models for complex questions on plant development

    NARCIS (Netherlands)

    Deinum, E.E.

    2013-01-01

      This thesis combines several modelling studies on plant growth and development. The core interest is the nitrogen fixing legume-rhizobium symbiosis, specifically how different signals interact in specifying the location of the nodule primordium. For one of them, the hormone cytokinin,

  1. Development of an animal model of selective coronary atherosclerosis

    NARCIS (Netherlands)

    Mihaylov, D; van Luyn, MJA; Rakhorst, G

    Background Atherosclerosis causes over 40% of all deaths in the USA and Western Europe. Although several hypotheses have been proposed, the etiology and pathogenesis of the atherosclerosis remain unknown. Objective To develop a model of selective coronary atherosclerosis in pigs. Design An animal

  2. Toward the Development of More Robust Policy Models

    Directory of Open Access Journals (Sweden)

    Steven E. Wallis

    2010-03-01

    Full Text Available The current state of the world suggests we have some difficulty in developing effective policy. This paper demonstrates two methods for the objective analysis of logic models within policy documents. By comparing policy models, we will be better able to compare policies and so determine which policy is best. Our ability to develop effective policy is reflected across the social sciences where our ability to create effective theoretical models is being called into question. The broad scope of this issue suggests a source as deep as our unconscious ways of thinking. Specifically, our reliance on modern and postmodern thinking has limited our ability to develop more effective policy, and more particularly, logic models. The move in some quarters toward “integral” thinking may provide insights that support the creation of more useful policy models. However, some versions of that thinking seem to be unwittingly mired in modern and postmodern thinking. This paper identifies how integral thought may be clarified, allowing us to advance beyond postmodern thinking. Usefully, this “neo-integral” form of thinking supports the creation of more mature policy models by encompassing greater complexity and a careful understanding of interrelationships that may be identified within the logic models that are commonly found in policy analyses. Neo-integral thinking is related to more complex forms of systems thinking and both are found in recent conversations within the nascent field of metatheory. And, to some extent, a logic model within a policy operates as a kind of theoretical model because both may be used to inform understanding and decision-making. Therefore, it seems reasonable to apply neo-integral thinking and metatheoretical methodologies to conduct critical comparisons of logic models. In the present paper, these methodologies are applied to critically compare two logic models. The structure of each model is analyzed to objectively determine

  3. Toward the Development of More Robust Policy Models

    Directory of Open Access Journals (Sweden)

    Steven E. Wallis

    2010-03-01

    Full Text Available The current state of the world suggests we have some difficulty in developing effective policy. This paper demonstrates two methods for the objective analysis of logic models within policy documents. By comparing policy models, we will be better able to compare policies and so determine which policy is best.Our ability to develop effective policy is reflected across the social sciences where our ability to create effective theoretical models is being called into question. The broad scope of this issue suggests a source as deep as our unconscious ways of thinking. Specifically, our reliance on modern and postmodern thinking has limited our ability to develop more effective policy, and more particularly, logic models. The move in some quarters toward “integral” thinking may provide insights that support the creation of more useful policy models. However, some versions of that thinking seem to be unwittingly mired in modern and postmodern thinking. This paper identifies how integral thought may be clarified, allowing us to advance beyond postmodern thinking. Usefully, this “neo-integral” form of thinking supports the creation of more mature policy models by encompassing greater complexity and a careful understanding of interrelationships that may be identified within the logic models that are commonly found in policy analyses. Neo-integral thinking is related to more complex forms of systems thinking and both are found in recent conversations within the nascent field of metatheory. And, to some extent, a logic model within a policy operates as a kind of theoretical model because both may be used to inform understanding and decision-making. Therefore, it seems reasonable to apply neo-integral thinking and metatheoretical methodologies to conduct critical comparisons of logic models. In the present paper, these methodologies are applied to critically compare two logic models. The structure of each model is analyzed to objectively determine

  4. Developing a dynamic growth model for teak plantations in India

    Directory of Open Access Journals (Sweden)

    Vindhya Prasad Tewari

    2014-05-01

    Full Text Available Background Tectona grandis (teak is one of the most important tropical timber speciesoccurring naturally in India. Appropriate growth models, based on advanced modeling techniques,are not available but are necessary for the successful management of teak stands in the country.Long-term forest planning requires mathematical models, and the principles of Dynamical SystemTheory provide a solid foundation for these. Methods The state-space approach makes it possible to accommodate disturbances and avarying environment. In this paper, an attempt has been made to develop a dynamic growthmodel based on the limited data, consisting of three annual measurements, collected from 22 teak sample plots in Karnataka, Southern India. Results A biologically consistent whole-stand growth model has been presented which uses thestate-space approach for modelling rates of change of three state-variables viz., dominant height,stems per hectare and stand basal area. Moreover, the model includes a stand volume equationas an output function to estimate this variable at any point in time. Transition functions werefitted separately and simultaneously. Moreover, a continuous autoregressive error structure isalso included in the modelling process. For fitting volume equation, generalized method of moments was used to get efficient parameter estimates under heteroscedastic conditions. Conclusions A simple model containing few free parameters performed well and is particularlywell suited to situations where available data is scarce.

  5. Enabling PBPK model development through the application of ...

    Science.gov (United States)

    The creation of Physiologically Based Pharmacokinetic (PBPK) models for a new chemical requires the selection of an appropriate model structure and the collection of a large amount of data for parameterization. Commonly, a large proportion of the needed information is collected from previously published PBPK models for compounds analogous to the chemical of interest. A key difficulty in quickly developing new models is therefore the identification of appropriate chemical analogs within PBPK model literature. To reduce the burden on researchers of finding the appropriate literature to inform new modeling efforts, we sought to collect a comprehensive listing of chemicals contained in the corpus of PBPK articles and embed them into a chemically searchable database for facile analog identification. To cull the list of chemicals from PBPK literature, we investigated the use of three easily accessible methods: collecting chemicals via MeSH controlled vocabulary processing abstracts using OSCAR4 text-mining software, and annotating abstracts using chemicalize.org. In total, just over 300 unique compounds spanning a variety of chemical classes were identified as having completed PBPK models from over 1700 articles. Additional annotations of PBPK model details including species, lifestage, number of compartments, gender, and exposure routes were tabulated. These data were then imbedded into the Toxicokinetic Knowledge Base (TKKB), an internal website for chemicall

  6. Development of a coupled wave-flow-vegetation interaction model

    Science.gov (United States)

    Beudin, Alexis; Kalra, Tarandeep S.; Ganju, Neil K.; Warner, John C.

    2017-01-01

    Emergent and submerged vegetation can significantly affect coastal hydrodynamics. However, most deterministic numerical models do not take into account their influence on currents, waves, and turbulence. In this paper, we describe the implementation of a wave-flow-vegetation module into a Coupled-Ocean-Atmosphere-Wave-Sediment Transport (COAWST) modeling system that includes a flow model (ROMS) and a wave model (SWAN), and illustrate various interacting processes using an idealized shallow basin application. The flow model has been modified to include plant posture-dependent three-dimensional drag, in-canopy wave-induced streaming, and production of turbulent kinetic energy and enstrophy to parameterize vertical mixing. The coupling framework has been updated to exchange vegetation-related variables between the flow model and the wave model to account for wave energy dissipation due to vegetation. This study i) demonstrates the validity of the plant posture-dependent drag parameterization against field measurements, ii) shows that the model is capable of reproducing the mean and turbulent flow field in the presence of vegetation as compared to various laboratory experiments, iii) provides insight into the flow-vegetation interaction through an analysis of the terms in the momentum balance, iv) describes the influence of a submerged vegetation patch on tidal currents and waves separately and combined, and v) proposes future directions for research and development.

  7. Development of animal models for hepatobiliary nuclear imaging

    Energy Technology Data Exchange (ETDEWEB)

    Park, Jin Hee; Park, Yun Hee; Ryu, Yeon Mi; Shin, Eun Kyung; Kim, Meyoung Kon [Korea University Medical College, Seoul (Korea, Republic of)

    2002-07-01

    Animal models for hepatobiliary disorders were classified into 2 different types: parenchymal hepatotoxicity and biliary-tract cholestasis. The purpose of this study was to develop animal models for hepatobiliary scintigraphy in evaluating a novel agents, such as {sup 99m}Tc-mercaptoacetyl triglycine(MAG3)-biocytin. Animal models were prepared by use of female Balb/c mice. Those were treated with 0.1, 0.5, and 2.5 ml/kg of carbon tetrachloride (CCl4) intraperitoneally for hepatotoxicity and with 30, 150, and 750 mg/kg of {alpha}-naphthylisothiocyanate (ANIT) to induce cholestasis. Dose of optimum was 0.5 ml/kg and 150 mg/kg for each model but lower (0.1 ml/kg and 30 mg/kg) and higher (2.5ml/kg and 750 mg/kg)were not be compatible for hepatobiliary models. Using these hepatobiliary models, {sup 99m}Tc-MAG3-biocytin scintigraphy was successfully carried out by using 4 parameters, e.g., peak liver/heat ratio (Rmax), peak ratio time (Tmax), half clearance time (HCT), and hepatic extraction fraction (HEF) for hepatotoxicity and cholestasis. Additionally, biochemical and histological analysis also resulted in confirming these animal models. Thus, we concluded that these animal models were highly likely to be efficient in evaluating hepatobiliary scintigraphic agent such as {sup 99m}Tc-MAG3-biocytin.

  8. A MULTISCALE, CELL-BASED FRAMEWORK FOR MODELING CANCER DEVELOPMENT

    Energy Technology Data Exchange (ETDEWEB)

    JIANG, YI [Los Alamos National Laboratory

    2007-01-16

    Cancer remains to be one of the leading causes of death due to diseases. We use a systems approach that combines mathematical modeling, numerical simulation, in vivo and in vitro experiments, to develop a predictive model that medical researchers can use to study and treat cancerous tumors. The multiscale, cell-based model includes intracellular regulations, cellular level dynamics and intercellular interactions, and extracellular level chemical dynamics. The intracellular level protein regulations and signaling pathways are described by Boolean networks. The cellular level growth and division dynamics, cellular adhesion and interaction with the extracellular matrix is described by a lattice Monte Carlo model (the Cellular Potts Model). The extracellular dynamics of the signaling molecules and metabolites are described by a system of reaction-diffusion equations. All three levels of the model are integrated through a hybrid parallel scheme into a high-performance simulation tool. The simulation results reproduce experimental data in both avasular tumors and tumor angiogenesis. By combining the model with experimental data to construct biologically accurate simulations of tumors and their vascular systems, this model will enable medical researchers to gain a deeper understanding of the cellular and molecular interactions associated with cancer progression and treatment.

  9. Modelling the development of mixing height in near equatorial region

    Energy Technology Data Exchange (ETDEWEB)

    Samah, A.A. [Univ. of Malaya, Air Pollution Research Unit, Kuala Lumpur (Malaysia)

    1997-10-01

    Most current air pollution models were developed for mid-latitude conditions and as such many of the empirical parameters used were based on observations taken in the mid-latitude boundary layer which is physically different from that of the equatorial boundary layer. In the equatorial boundary layer the Coriolis parameter f is small or zero and moisture plays a more important role in the control of stability and the surface energy balance. Therefore air pollution models such as the OMLMULTI or the ADMS which were basically developed for mid-latitude conditions must be applied with some caution and would need some adaptation to properly simulate the properties of equatorial boundary layer. This work elucidates some of the problems of modelling the evolution of mixing height in the equatorial region. The mixing height estimates were compared with routine observations taken during a severe air pollution episodes in Malaysia. (au)

  10. Developing a new stochastic competitive model regarding inventory and price

    Science.gov (United States)

    Rashid, Reza; Bozorgi-Amiri, Ali; Seyedhoseini, S. M.

    2015-01-01

    Within the competition in today's business environment, the design of supply chains becomes more complex than before. This paper deals with the retailer's location problem when customers choose their vendors, and inventory costs have been considered for retailers. In a competitive location problem, price and location of facilities affect demands of customers; consequently, simultaneous optimization of the location and inventory system is needed. To prepare a realistic model, demand and lead time have been assumed as stochastic parameters, and queuing theory has been used to develop a comprehensive mathematical model. Due to complexity of the problem, a branch and bound algorithm has been developed, and its performance has been validated in several numerical examples, which indicated effectiveness of the algorithm. Also, a real case has been prepared to demonstrate performance of the model for real world.

  11. Advanced parallel programming models research and development opportunities.

    Energy Technology Data Exchange (ETDEWEB)

    Wen, Zhaofang.; Brightwell, Ronald Brian

    2004-07-01

    There is currently a large research and development effort within the high-performance computing community on advanced parallel programming models. This research can potentially have an impact on parallel applications, system software, and computing architectures in the next several years. Given Sandia's expertise and unique perspective in these areas, particularly on very large-scale systems, there are many areas in which Sandia can contribute to this effort. This technical report provides a survey of past and present parallel programming model research projects and provides a detailed description of the Partitioned Global Address Space (PGAS) programming model. The PGAS model may offer several improvements over the traditional distributed memory message passing model, which is the dominant model currently being used at Sandia. This technical report discusses these potential benefits and outlines specific areas where Sandia's expertise could contribute to current research activities. In particular, we describe several projects in the areas of high-performance networking, operating systems and parallel runtime systems, compilers, application development, and performance evaluation.

  12. Development of a gas systems analysis model (GSAM)

    Energy Technology Data Exchange (ETDEWEB)

    Godec, M.L. [IFC Resources Inc., Fairfax, VA (United States)

    1995-04-01

    The objectives of developing a Gas Systems Analysis Model (GSAM) are to create a comprehensive, non-proprietary, PC based model of domestic gas industry activity. The system is capable of assessing the impacts of various changes in the natural gas system within North America. The individual and collective impacts due to changes in technology and economic conditions are explicitly modeled in GSAM. Major gas resources are all modeled, including conventional, tight, Devonian Shale, coalbed methane, and low-quality gas sources. The modeling system asseses all key components of the gas industry, including available resources, exploration, drilling, completion, production, and processing practices, both for now and in the future. The model similarly assesses the distribution, storage, and utilization of natural gas in a dynamic market-based analytical structure. GSAM is designed to provide METC managers with a tool to project the impacts of future research, development, and demonstration (RD&D) benefits in order to determine priorities in a rapidly changing, market-driven gas industry.

  13. Development of the IAP Dynamic Global Vegetation Model

    Science.gov (United States)

    Zeng, Xiaodong; Li, Fang; Song, Xiang

    2014-05-01

    The IAP Dynamic Global Vegetation Model (IAP-DGVM) has been developed to simulate the distribution and structure of global vegetation within the framework of Earth System Models. It incorporates our group's recent developments of major model components such as the shrub sub-model, establishment and competition parameterization schemes, and a process-based fire parameterization of intermediate complexity. The model has 12 plant functional types, including seven tree, two shrub, and three grass types, plus bare soil. Different PFTs are allowed to coexist within a grid cell, and their state variables are updated by various governing equations describing vegetation processes from fine-scale biogeophysics and biogeochemistry, to individual and population dynamics, to large-scale biogeography. Environmental disturbance due to fire not only affects regional vegetation competition, but also influences atmospheric chemistry and aerosol emissions. Simulations under observed atmospheric conditions showed that the model can correctly reproduce the global distribution of trees, shrubs, grasses, and bare soil. The simulated global dominant vegetation types reproduce the transition from forest to grassland (savanna) in the tropical region, and from forest to shrubland in the boreal region, but overestimate the region of temperate forest.

  14. Development of affective modelling competencies in primary school learners

    Directory of Open Access Journals (Sweden)

    Piera Biccard

    2011-10-01

    Full Text Available Learner affect and beliefs about mathematics are complex and multifaceted aspects of mathematical learning. Traditional teaching and learning approaches in mathematics education often result in problematic beliefs about mathematics. Since beliefs influence what learners learn and how they deal with learning mathematics, it is essential that the roles of beliefs and affect in mathematics classrooms are carefully examined. In solving modelling problems, learners and teachers take on new roles in the classroom: learners are placed in an active, self-directing situation in which they solve real-world problems. When learners engage in modelling tasks, they display and integrate cognitive, meta-cognitive and affective competencies. A modelling approach therefore allows one to detect learner beliefs in an authentic learning environment. Will this environment lead to students having more positive and productive dispositions towards mathematics? This article presents partial results of a study documenting the development of modelling competencies in learners working in groups over a period of 12 weeks. Through a design research approach, 12 learners working in groups solved three modelling problems, and transcriptions of learner interactions, questionnaires and informal interviews revealed that learner beliefs improved over this short period when exposed to modelling tasks. The results are encouraging, and may provide mathematics education with an avenue to develop more positive learner beliefs in mathematics.

  15. Predictive modeling of signaling crosstalk during C. elegans vulval development.

    Directory of Open Access Journals (Sweden)

    Jasmin Fisher

    2007-05-01

    Full Text Available Caenorhabditis elegans vulval development provides an important paradigm for studying the process of cell fate determination and pattern formation during animal development. Although many genes controlling vulval cell fate specification have been identified, how they orchestrate themselves to generate a robust and invariant pattern of cell fates is not yet completely understood. Here, we have developed a dynamic computational model incorporating the current mechanistic understanding of gene interactions during this patterning process. A key feature of our model is the inclusion of multiple modes of crosstalk between the epidermal growth factor receptor (EGFR and LIN-12/Notch signaling pathways, which together determine the fates of the six vulval precursor cells (VPCs. Computational analysis, using the model-checking technique, provides new biological insights into the regulatory network governing VPC fate specification and predicts novel negative feedback loops. In addition, our analysis shows that most mutations affecting vulval development lead to stable fate patterns in spite of variations in synchronicity between VPCs. Computational searches for the basis of this robustness show that a sequential activation of the EGFR-mediated inductive signaling and LIN-12 / Notch-mediated lateral signaling pathways is key to achieve a stable cell fate pattern. We demonstrate experimentally a time-delay between the activation of the inductive and lateral signaling pathways in wild-type animals and the loss of sequential signaling in mutants showing unstable fate patterns; thus, validating two key predictions provided by our modeling work. The insights gained by our modeling study further substantiate the usefulness of executing and analyzing mechanistic models to investigate complex biological behaviors.

  16. A model for curriculum development and student evaluation

    Directory of Open Access Journals (Sweden)

    Šefer Jasmina P.

    2002-01-01

    Full Text Available The paper outlines theoretical foundations for investigations to be conducted in our education, based on USA (DISCOVERY and Yugoslav (CREATIVITY previous projects that dealt with developing, investigating and evaluating (a abilities of creative problem solving within seven types of intelligence after the Gardner model and (b curriculum that provides and encourages the development of those abilities. Divergent thinking and creativity in all spheres of intellectual behavior in teaching are encouraged by introducing open-type questions, play, exploring activities and multimedia integrative-interdisciplinary thematic approach to problem solving. Multiple intelligence and a dimensional model of problem solving present theoretical foundations for curriculum development and a new qualitative approach to process evaluation of student's various abilities. Investigations should make provisions for comparing the results obtained in various cultures and for integrating best solutions into a common whole. Comparing the results of cultures and testing theoretical models and instruments for the evaluation of students are the outcomes essential to the science of pedagogy. Curriculum development oriented to problem and divergent thinking in different areas, intellectual functioning, and enrichment of the choice of instruments for multiple process evaluation of students can also significantly contribute to the current reform of Yugoslav school, development of student abilities and teacher education and in-service training.

  17. Beijing Model of Gifted Education and Talent Development

    DEFF Research Database (Denmark)

    Fang, Zhongxiong; Zhang, Yi; Du, Xiangyun

    In China, talent development has been one of the key points in national plans for the development of science and technology, education, and other areas over the last three decades and is especially emphasized in the national outline for medium- and long-term educational reform and development....... Beijing is the leading city in educational reform, especially in the area of gifted education in mainland China. Over the past 35 years, through constant exploration and research, a comprehensive gifted education system called the Beijing Model of Gifted Education and Talent Development (BMGETD) has...... gradually been developed. This book is a summary of the educational practices used in and research done on the BMGETD over the decades. These include several patterns for gifted education, such as acceleration in special classes, special classes without acceleration, enrichment within regular classes...

  18. A neuroconstructivist model of past tense development and processing.

    Science.gov (United States)

    Westermann, Gert; Ruh, Nicolas

    2012-07-01

    We present a neural network model of learning and processing the English past tense that is based on the notion that experience-dependent cortical development is a core aspect of cognitive development. During learning the model adds and removes units and connections to develop a task-specific final architecture. The model provides an integrated account of characteristic errors during learning the past tense, adult generalization to pseudoverbs, and dissociations between verbs observed after brain damage in aphasic patients. We put forward a theory of verb inflection in which a functional processing architecture develops through interactions between experience-dependent brain development and the structure of the environment, in this case, the statistical properties of verbs in the language. The outcome of this process is a structured processing system giving rise to graded dissociations between verbs that are easy and verbs that are hard to learn and process. In contrast to dual-mechanism accounts of inflection, we argue that describing dissociations as a dichotomy between regular and irregular verbs is a post hoc abstraction and is not linked to underlying processing mechanisms. We extend current single-mechanism accounts of inflection by highlighting the role of structural adaptation in development and in the formation of the adult processing system. In contrast to some single-mechanism accounts, we argue that the link between irregular inflection and verb semantics is not causal and that existing data can be explained on the basis of phonological representations alone. This work highlights the benefit of taking brain development seriously in theories of cognitive development. Copyright 2012 APA, all rights reserved.

  19. Theory of positive disintegration as a model of adolescent development.

    Science.gov (United States)

    Laycraft, Krystyna

    2011-01-01

    This article introduces a conceptual model of the adolescent development based on the theory of positive disintegration combined with theory of self-organization. Dabrowski's theory of positive disintegration, which was created almost a half century ago, still attracts psychologists' and educators' attention, and is extensively applied into studies of gifted and talented people. The positive disintegration is the mental development described by the process of transition from lower to higher levels of mental life and stimulated by tension, inner conflict, and anxiety. This process can be modeled by a sequence of patterns of organization (attractors) as a developmental potential (a control parameter) changes. Three levels of disintegration (unilevel disintegration, spontaneous multilevel disintegration, and organized multilevel disintegration) are analyzed in detail and it is proposed that they represent behaviour of early, middle and late periods of adolescence. In the discussion, recent research on the adolescent brain development is included.

  20. Genetic Animal Models of Malformations of Cortical Development and Epilepsy

    Science.gov (United States)

    Wong, Michael; Roper, Steven N.

    2015-01-01

    Malformations of cortical development constitute a variety of pathological brain abnormalities that commonly cause severe, medically-refractory epilepsy, including focal lesions, such as focal cortical dysplasia, hetereotopias, and tubers of tuberous sclerosis complex, and diffuse malformations, such as lissencephaly. Although some cortical malformations result from environmental insults during cortical development in utero, genetic factors are increasingly recognized as primary pathogenic factors across the entire spectrum of malformations. Genes implicated in causing different cortical malformations are involved in a variety of physiological functions, but many are focused on regulation of cell proliferation, differentiation, and neuronal migration. Advances in molecular genetic methods have allowed the engineering of increasingly sophisticated animal models of cortical malformations and associated epilepsy. These animal models have identified some common mechanistic themes shared by a number of different cortical malformations, but also revealed the diversity and complexity of cellular and molecular mechanisms that lead to the development of the pathological lesions and resulting epileptogenesis. PMID:25911067