WorldWideScience

Sample records for psc resources palmer

  1. Palmer Drought Severity Index

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — PDSI from the Dai dataset. The Palmer Drought Severity Index (PDSI) is devised by Palmer (1965) to represent the severity of dry and wet spells over the U.S. based...

  2. iPSCORE: A Resource of 222 iPSC Lines Enabling Functional Characterization of Genetic Variation across a Variety of Cell Types

    Directory of Open Access Journals (Sweden)

    Athanasia D. Panopoulos

    2017-04-01

    Full Text Available Large-scale collections of induced pluripotent stem cells (iPSCs could serve as powerful model systems for examining how genetic variation affects biology and disease. Here we describe the iPSCORE resource: a collection of systematically derived and characterized iPSC lines from 222 ethnically diverse individuals that allows for both familial and association-based genetic studies. iPSCORE lines are pluripotent with high genomic integrity (no or low numbers of somatic copy-number variants as determined using high-throughput RNA-sequencing and genotyping arrays, respectively. Using iPSCs from a family of individuals, we show that iPSC-derived cardiomyocytes demonstrate gene expression patterns that cluster by genetic background, and can be used to examine variants associated with physiological and disease phenotypes. The iPSCORE collection contains representative individuals for risk and non-risk alleles for 95% of SNPs associated with human phenotypes through genome-wide association studies. Our study demonstrates the utility of iPSCORE for examining how genetic variants influence molecular and physiological traits in iPSCs and derived cell lines.

  3. The ROSA26-iPSC Mouse: A Conditional, Inducible, and Exchangeable Resource for Studying Cellular (DeDifferentiation

    Directory of Open Access Journals (Sweden)

    Lieven Haenebalcke

    2013-02-01

    Full Text Available Control of cellular (dedifferentiation in a temporal, cell-specific, and exchangeable manner is of paramount importance in the field of reprogramming. Here, we have generated and characterized a mouse strain that allows iPSC generation through the Cre/loxP conditional and doxycycline/rtTA-controlled inducible expression of the OSKM reprogramming factors entirely from within the ROSA26 locus. After reprogramming, these factors can be replaced by genes of interest—for example, to enhance lineage-directed differentiation—with the use of a trap-coupled RMCE reaction. We show that, similar to ESCs, Dox-controlled expression of the cardiac transcriptional regulator Mesp1 together with Wnt inhibition enhances the generation of functional cardiomyocytes upon in vitro differentiation of such RMCE-retargeted iPSCs. This ROSA26-iPSC mouse model is therefore an excellent tool for studying both cellular reprogramming and lineage-directed differentiation factors from the same locus and will greatly facilitate the identification and ease of functional characterization of the genetic/epigenetic determinants involved in these complex processes.

  4. iPSC Core

    Data.gov (United States)

    Federal Laboratory Consortium — The induced Pluripotent Stem Cells (iPSC) Core was created in 2011 to accelerate stem cell research in the NHLBI by providing investigators consultation, technical...

  5. Palmer Amaranth Identification and Documentation of Herbicide Resistance in Argentina

    Science.gov (United States)

    Palmer amaranth (Amaranthuspalmeri S. Wats.) has greatly disrupted agricultural practices in the US with its rapid growth and rapid evolution of herbicide resistance. This weed species is now suspected in Argentina. To document whether the suspected plant populations are indeed Palmer amaranth, mo...

  6. Palmer amaranth (Amaranthus palmeri) competition for water in cotton

    Science.gov (United States)

    Palmer amaranth is a troublesome weed in cotton production. Yield losses of 65% have been reported due to season-long Palmer amaranth competition with cotton. To determine if water is a factor in this system, experiments were conducted in 2011, 2012, and 2013 in Citra, FL and in Tifton, GA. In 2011,...

  7. Prokofiev: War and Peace - Symphonic Suite (arr. Palmer) / Ivan March

    Index Scriptorium Estoniae

    March, Ivan

    1993-01-01

    Uuest heliplaadist "Prokofiev: War and Peace - Symphonic Suite (arr. Palmer), Summer Night, Op. 123. Russian Overture, Op. 72. Philharmonia Orchestra / Neeme Järvi. Chandos ABTD 1598 CHAN9096 (64 minutes:DDD) Igor - Polovtsian Dances

  8. Climate Prediction Center (CPC) Palmer Drought and Crop Moisture Indices

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Climate Prediction Center (CPC) Palmer Drought Severity and Crop Moisture Indices are computed for the 344 U.S. Climate Divisions on a weekly basis based on a...

  9. Research Ship Nathaniel B. Palmer Underway Meteorological Data, Quality Controlled

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Research Ship Nathaniel B. Palmer Underway Meteorological Data (delayed ~10 days for quality control) are from the Shipboard Automated Meteorological and...

  10. A multiscalar Palmer drought severity index

    Science.gov (United States)

    Liu, Yi; Zhu, Ye; Ren, Liliang; Singh, Vijay P.; Yang, Xiaoli; Yuan, Fei

    2017-07-01

    The limitation of the fixed time scale in the Palmer drought severity index (PDSI) family has long been criticized in drought literatures. By modifying the algorithm of duration factors estimation of the self-calibrating PDSI (SC-PDSI), this paper proposed a new approach that could extend the time scale in a wide range. The properties of these newly derived SC-PDSI variants (denoted as SC-PDSIx) at short, medium, and long time scales, respectively, were evaluated through comparisons with the multiscalar standardized precipitation evapotranspiration index (SPEI) over 134 meteorological sites in China. Results show that new SC-PDSIx generally inherits the advantages of original SC-PDSI with a rather stable behavior in aspects of drought frequency and other statistical characteristics. Besides, the spatiotemporal pattern of the 2011 drought reflected by matched SC-PDSIx and SPEI is very similar, indicating that the multiscalar SC-PDSI could be a useful alternative to monitor droughts at different time scales.

  11. Breathing Silence. An interview with John Palmer

    Directory of Open Access Journals (Sweden)

    Cristina Scuderi

    2011-07-01

    Full Text Available The interview focuses on some aspects of the composer’s work with electronics. Palmer, described by the critics as «undoubtedly the most visionary composer of his generation» speaks about the composers and musical works that have had a major impact on him. He also mentions the friendship with John Cage, his numerous travels – with particular emphasis on Japan – and the influence of Eastern culture on his musical mind. The composer discusses the notion of causality explored in Renge-Kyo, the meditative nature of Transient and Inwards, and spirituality as the central theme of both acousmatic works In the Temple and I Am. The electronic medium is also por- trayed as a mirror of an intense and vivid preoccupation for intimacy and perpetual search for timbral qualities that by now characterize most of his music. Another important aspect of Palmer’s work mentioned in the interview is the collaboration with some established performers and its importance for the realization of a musical work.

  12. Road to future: iPSC clinical application in Parkinson's disease treatment.

    Science.gov (United States)

    Xu, L; Tan, Y-Y; Wu, L; Wang, L-L; Li, H; Ding, J-Q; Chen, S-D

    2013-11-01

    Cell-replacement therapy using Parkinson's disease (PD) specific induced pluripotent stem cell (iPSC) holds great promise in treating PD. However, the problem of iPSC safety and efficiency restrict its clinical application. Meanwhile the requirement of skin biopsy for fibroblast will increase the risk of complication. In the past few years, the advances of iPSC technology in efficiency, cell resource, safety and cell culture have made it possible to use the derivatives of iPSCs to clinical PD treatment. This review will summarize these progresses of iPSC technique in this fast-moving community.

  13. File list: Oth.PSC.20.AllAg.iPSC_intermediates [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.20.AllAg.iPSC_intermediates mm9 TFs and others Pluripotent stem cell iPSC intermedia...7379,SRX977371,SRX977370,SRX897943,SRX1184107,SRX897941 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.20.AllAg.iPSC_intermediates.bed ...

  14. File list: ALL.PSC.20.AllAg.iPSC_intermediates [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.PSC.20.AllAg.iPSC_intermediates mm9 All antigens Pluripotent stem cell iPSC intermedia...4,SRX1184108,SRX897944,SRX1178447,SRX684778,SRX1090865,SRX684777,SRX1090866 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/ALL.PSC.20.AllAg.iPSC_intermediates.bed ...

  15. File list: DNS.PSC.10.AllAg.iPSC_intermediates [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available DNS.PSC.10.AllAg.iPSC_intermediates mm9 DNase-seq Pluripotent stem cell iPSC intermedia...tes http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/DNS.PSC.10.AllAg.iPSC_intermediates.bed ...

  16. File list: Unc.PSC.20.AllAg.iPSC_intermediates [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Unc.PSC.20.AllAg.iPSC_intermediates mm9 Unclassified Pluripotent stem cell iPSC intermedia...tes http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Unc.PSC.20.AllAg.iPSC_intermediates.bed ...

  17. File list: ALL.PSC.50.AllAg.iPSC_intermediates [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.PSC.50.AllAg.iPSC_intermediates mm9 All antigens Pluripotent stem cell iPSC intermedia...44,SRX897944,SRX1178447,SRX684776,SRX684778,SRX684777,SRX1090865,SRX1090866 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/ALL.PSC.50.AllAg.iPSC_intermediates.bed ...

  18. File list: DNS.PSC.50.AllAg.iPSC_intermediates [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available DNS.PSC.50.AllAg.iPSC_intermediates mm9 DNase-seq Pluripotent stem cell iPSC intermedia...tes http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/DNS.PSC.50.AllAg.iPSC_intermediates.bed ...

  19. File list: ALL.PSC.10.AllAg.iPSC_intermediates [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.PSC.10.AllAg.iPSC_intermediates mm9 All antigens Pluripotent stem cell iPSC intermedia...,SRX1178446,SRX1178449,SRX1178447,SRX897944,SRX1090865,SRX684777,SRX1090866 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/ALL.PSC.10.AllAg.iPSC_intermediates.bed ...

  20. File list: Oth.PSC.05.AllAg.iPSC_intermediates [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.05.AllAg.iPSC_intermediates mm9 TFs and others Pluripotent stem cell iPSC intermedia...7367,SRX977374,SRX897943,SRX977378,SRX1184107,SRX897941 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.05.AllAg.iPSC_intermediates.bed ...

  1. File list: Pol.PSC.50.AllAg.iPSC_intermediates [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.PSC.50.AllAg.iPSC_intermediates mm9 RNA polymerase Pluripotent stem cell iPSC intermedia...e.biosciencedbc.jp/kyushu-u/mm9/assembled/Pol.PSC.50.AllAg.iPSC_intermediates.bed ...

  2. File list: Pol.PSC.05.AllAg.iPSC_intermediates [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.PSC.05.AllAg.iPSC_intermediates mm9 RNA polymerase Pluripotent stem cell iPSC intermedia...e.biosciencedbc.jp/kyushu-u/mm9/assembled/Pol.PSC.05.AllAg.iPSC_intermediates.bed ...

  3. File list: DNS.PSC.05.AllAg.iPSC_intermediates [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available DNS.PSC.05.AllAg.iPSC_intermediates mm9 DNase-seq Pluripotent stem cell iPSC intermedia...tes http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/DNS.PSC.05.AllAg.iPSC_intermediates.bed ...

  4. File list: ALL.PSC.05.AllAg.iPSC_intermediates [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.PSC.05.AllAg.iPSC_intermediates mm9 All antigens Pluripotent stem cell iPSC intermedia...6,SRX1184108,SRX897944,SRX1178447,SRX684778,SRX684777,SRX1090865,SRX1090866 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/ALL.PSC.05.AllAg.iPSC_intermediates.bed ...

  5. File list: Oth.PSC.10.AllAg.iPSC_intermediates [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.10.AllAg.iPSC_intermediates mm9 TFs and others Pluripotent stem cell iPSC intermedia...7378,SRX897943,SRX977370,SRX977371,SRX1184107,SRX897941 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.10.AllAg.iPSC_intermediates.bed ...

  6. File list: Pol.PSC.20.AllAg.iPSC_intermediates [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.PSC.20.AllAg.iPSC_intermediates mm9 RNA polymerase Pluripotent stem cell iPSC intermedia...e.biosciencedbc.jp/kyushu-u/mm9/assembled/Pol.PSC.20.AllAg.iPSC_intermediates.bed ...

  7. File list: Oth.PSC.50.AllAg.iPSC_intermediates [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.50.AllAg.iPSC_intermediates mm9 TFs and others Pluripotent stem cell iPSC intermedia...7379,SRX977371,SRX977370,SRX897943,SRX897941,SRX1184107 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.50.AllAg.iPSC_intermediates.bed ...

  8. File list: Pol.PSC.10.AllAg.iPSC_intermediates [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.PSC.10.AllAg.iPSC_intermediates mm9 RNA polymerase Pluripotent stem cell iPSC intermedia...e.biosciencedbc.jp/kyushu-u/mm9/assembled/Pol.PSC.10.AllAg.iPSC_intermediates.bed ...

  9. File list: Unc.PSC.10.AllAg.iPSC_intermediates [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Unc.PSC.10.AllAg.iPSC_intermediates mm9 Unclassified Pluripotent stem cell iPSC intermedia...tes http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Unc.PSC.10.AllAg.iPSC_intermediates.bed ...

  10. File list: Unc.PSC.50.AllAg.iPSC_intermediates [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Unc.PSC.50.AllAg.iPSC_intermediates mm9 Unclassified Pluripotent stem cell iPSC intermedia...tes http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Unc.PSC.50.AllAg.iPSC_intermediates.bed ...

  11. File list: Unc.PSC.05.AllAg.iPSC_intermediates [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Unc.PSC.05.AllAg.iPSC_intermediates mm9 Unclassified Pluripotent stem cell iPSC intermedia...tes http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Unc.PSC.05.AllAg.iPSC_intermediates.bed ...

  12. File list: DNS.PSC.20.AllAg.iPSC_intermediates [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available DNS.PSC.20.AllAg.iPSC_intermediates mm9 DNase-seq Pluripotent stem cell iPSC intermedia...tes http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/DNS.PSC.20.AllAg.iPSC_intermediates.bed ...

  13. George Rupert Palmer--DRG carrier and champion.

    Science.gov (United States)

    Turner, L; Short, S D

    1999-01-01

    Prompted by the retirement of the distinguished health economist, researcher and academic, Professor George Rupert Palmer, the purpose of this paper is to reflect upon and acknowledge one of his many contributions to health services research and development. By employing a conceptual framework devised by Kimberly and de Pouvourville (1993) for analysis of the diffusion of innovations, this paper argues that Palmer played a crucial role in the diffusion into and within Australia of a particular casemix method, diagnosis related groups (DRGs). Textual and interview evidence presented in the paper supports the identification of George Rupert Palmer as the principal carrier of DRGs into Australia, and as one of its key champions within Australia.

  14. Resources

    Science.gov (United States)

    ... disease - resources Hemophilia - resources Herpes - resources Incest - resources Incontinence - resources Infertility - resources Interstitial cystitis - resources Kidney disease - resources Leukemia - resources Liver disease - resources Loss ...

  15. Analysis list: Psc [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Psc Cell line,Embryo + dm3 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/target/Ps...c.1.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/target/Psc.5.tsv http://dbarchive.biosciencedbc.jp/ky...ushu-u/dm3/target/Psc.10.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/colo/Psc.Cell_line.tsv,http://dbarchive.bioscience...dbc.jp/kyushu-u/dm3/colo/Psc.Embryo.tsv http://dbarchive.bioscience...dbc.jp/kyushu-u/dm3/colo/Cell_line.gml,http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/colo/Embryo.gml ...

  16. Exploring the Components of the Palmer Drought Indices Using the Apalachicola-Chattahoochee-Flint (ACF) River Basin as a Case Study

    Science.gov (United States)

    Perrone, D.; Duncan, L. L.; Jacobi, J. H.; Hornberger, G.

    2012-12-01

    Water resources are vital to sustaining ecosystem services, energy and food supplies, and industrial processes. Competition for water resources is likely to intensify as the population increases, economy grows, and land develops. Drought events intensify water scarcity, and recent events in many countries, including the United States (US), Great Britain, and Sri Lanka, highlight how important it is to provide meaningful context to water planners and managers. Palmer's drought indices - Z Index, Palmer Drought Severity Index (PDSI), and Palmer Hydrological Drought Index (PHDI) - are widely used and accepted by scientists and policy makers in the US to understand drought and manage water resources. Drought index values at the climate division scale are available, but a transparent calculation tool at multiple spatial and temporal scales is not readily available. Moreover, a close look at the development of the indices reveals a number of subjective calculation methods and regionally biased factors. For researchers studying areas with overlapping climate divisions, performing international research, or working with limited, site-specific data, the ability to control and modify calculations is desired. This research presents a transparent tool for calculating Palmer's drought indices. We use the Apalachicola-Chattahoochee-Flint (ACF) River Basin, located in the southeastern US, as our case study to explore and evaluate the sensitivity of Palmer's indices to temperature and precipitation anomalies, calibration periods, and other index components. The ACF has suffered two major droughts (2007 and 2012) in the past five years and supports multiple demand-side sectors - agriculture in Georgia, public and recreational supply for the Atlanta metropolitan area, hydroelectric power in Alabama, tri-state navigation, and ecosystem services. We show how the PDSI varies in response to changes in precipitation, calibration period, and a number of other variables. The aim of the

  17. Modified Palmer Drought Severity Index Based on Distributed Hydrological Simulation

    Directory of Open Access Journals (Sweden)

    Denghua Yan

    2013-01-01

    Full Text Available Drought monitoring at large scale is essential for fighting against drought. Aiming at the limitation of acquiring long-time serial soil moisture and actual evapotranspiration for Palmer drought severity index (PDSI, the paper modified the PDSI based on distributed hydrological model on subbasin level in Luanhe river basin, North China. The water balance was simulated using the Soil and Water Assessment Tool (SWAT. Calibration and validation results showed good agreement between simulated and measured discharges, and the SWAT model can be used to predict hydrological processes in the study area. Then the simulation results of main hydrologic components were used to establish PDSI. The verification of the drought indices showed that the modified PDSI based on SWAT model and Palmer drought severity index could better describe the characteristics of regional drought evolution in the Luanhe river basin. High drought frequency areas were mainly distributed in the grassland regions of upstream located in the eastern part of Inner Mongolia plateau, and the drought area had a significant upward trend form 1973 to 2010. Compared with the traditional Palmer drought severity index, the modified PDSI could reflect the spatial heterogeneity of regional drought and improve the physical mechanism of PDSI. The drought monitoring method can provide technical support for comprehensive understanding of drought and effective preventing and relieving of drought disasters.

  18. John Twysden and John Palmer: 17th-century Northamptonshire astronomers

    Science.gov (United States)

    Frost, M. A.

    2008-01-01

    John Twysden (1607-1688) and John Palmer (1612-1679) were two astronomers in the circle of Samuel Foster (circa 1600-1652), the subject of a recent paper in this journal. John Twysden qualified in law and medicine and led a peripatetic life around England and Europe. John Palmer was Rector of Ecton, Northamptonshire and later Archdeacon of Northampton. The two astronomers catalogued observations made from Northamptonshire from the 1640s to the 1670s. In their later years Twysden and Palmer published works on a variety of topics, often astronomical. Palmer engaged in correspondence with Henry Oldenburg, the first secretary of the Royal Society, on topics in astronomy and mathematics.

  19. File list: InP.PSC.20.AllAg.iPSC_intermediates [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.PSC.20.AllAg.iPSC_intermediates mm9 Input control Pluripotent stem cell iPSC intermedia...178446,SRX1178444,SRX1178449,SRX1184108,SRX897944,SRX1178447 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/InP.PSC.20.AllAg.iPSC_intermediates.bed ...

  20. File list: InP.PSC.05.AllAg.iPSC_intermediates [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.PSC.05.AllAg.iPSC_intermediates mm9 Input control Pluripotent stem cell iPSC intermedia...178445,SRX1178449,SRX1178446,SRX1184108,SRX897944,SRX1178447 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/InP.PSC.05.AllAg.iPSC_intermediates.bed ...

  1. File list: NoD.PSC.20.AllAg.iPSC_intermediates [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available NoD.PSC.20.AllAg.iPSC_intermediates mm9 No description Pluripotent stem cell iPSC intermedia...tes http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/NoD.PSC.20.AllAg.iPSC_intermediates.bed ...

  2. File list: NoD.PSC.10.AllAg.iPSC_intermediates [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available NoD.PSC.10.AllAg.iPSC_intermediates mm9 No description Pluripotent stem cell iPSC intermedia...tes http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/NoD.PSC.10.AllAg.iPSC_intermediates.bed ...

  3. File list: NoD.PSC.50.AllAg.iPSC_intermediates [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available NoD.PSC.50.AllAg.iPSC_intermediates mm9 No description Pluripotent stem cell iPSC intermedia...tes http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/NoD.PSC.50.AllAg.iPSC_intermediates.bed ...

  4. File list: NoD.PSC.05.AllAg.iPSC_intermediates [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available NoD.PSC.05.AllAg.iPSC_intermediates mm9 No description Pluripotent stem cell iPSC intermedia...tes http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/NoD.PSC.05.AllAg.iPSC_intermediates.bed ...

  5. File list: InP.PSC.10.AllAg.iPSC_intermediates [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.PSC.10.AllAg.iPSC_intermediates mm9 Input control Pluripotent stem cell iPSC intermedia...184108,SRX1178445,SRX1178446,SRX1178449,SRX1178447,SRX897944 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/InP.PSC.10.AllAg.iPSC_intermediates.bed ...

  6. File list: InP.PSC.50.AllAg.iPSC_intermediates [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.PSC.50.AllAg.iPSC_intermediates mm9 Input control Pluripotent stem cell iPSC intermedia...178448,SRX1178449,SRX1184108,SRX1178444,SRX897944,SRX1178447 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/InP.PSC.50.AllAg.iPSC_intermediates.bed ...

  7. New geophysical models of Palmer Deep crustal structure

    Science.gov (United States)

    Yakymchuk, M. A.; Levashov, S. P.; Korchagin, I. N.; Bachmutov, V. G.; Solovyov, V. D.

    2009-04-01

    The 2004 (9th) and 2006 (11th) Ukrainian Antarctic expeditions acquired new geoelectrical data (‘short-impulse electromagnetic field formation' - FSPEF, and ‘vertical electric-resonance sounding' - VERS) along profiles across Drake Passage and along Bransfield Strait, Antarctic Peninsula, with the aim of studying the crustal structure of these features down to depths of >30 km. The sounding on this depth in Antarctic region was the first experience of deep modification of the VERS method using. Modelling experience of deep crustal structure by geophysical data with VERS method shows that there is a possibility to investigate the fluid regime, tectonic disturbances and crush zones in basement and local places of submarine volcanic activity too. This technology also gives a possibility to efficiently divide the cross-section on separate stratigraphic subsections in the sounding site and to determine its depth with high accuracy (Levashov et al., 2003; Levashov et al., 2007). Geophysical surveys enabled to yield new data set with information about Drake Passage and Palmer Deep inner crustal structure on broad continental margin of Antarctic Peninsula. Palmer Deep is located on continental (Pacific) shelf of the Antarctic Peninsula near Anvers Island and consists of three deep basins with depths from 1200м to 1500м. These basins were part of glacial outlet during glaciation's period (Rebesco et al., 1998). Geoelectrical models of Palmer Deep crustal structure along three profiles were built on the sounding data in separate points of continental shelf. Heterogeneity of Palmer Deep earth's crust obtained from VERS data modelling testified to processes of tectonic transformations of internal shelf structures. Tectonic factor explains some conformities of the most recent glaciomarine sediments and glacial streams forming during recent shelf-wide glaciations. New information about sediment distribution and inner crustal structure has an important value for searching

  8. Genomic stability of Palmer amaranth plants derived by macro-vegetative propagation

    Science.gov (United States)

    Q-PCR (quantitative polymerase chain reaction) and random amplified polymorphic DNA (RAPD) were utilized to investigate genetic stability of Palmer amaranth cloned plants over 10 generations. Q-PCR analysis of DNA from parent Palmer amaranth plants was repeated and confidence levels for determining ...

  9. Glyphosate-resistant Palmer amaranth (Amaranthus palmeri) morphology, growth, and seed production in Georgia

    Science.gov (United States)

    Herbicide resistant Palmer amaranth has become the most economically detrimental weed of cotton in the Southeast US. With the continual marginalization of potential herbicide tools, research has expanded to include alternative means of affecting future Palmer amaranth populations by altering safe s...

  10. Factors affecting potential for Palmer amaranth (Amaranthus palmeri) suppression by winter rye in Georgia, USA

    Science.gov (United States)

    Herbicide resistant Palmer amaranth has rapidly become a dominant weed management issue in agronomic crops of the Southeast U. S. The small size of Palmer amaranth seeds, relative to other common weeds, provides an opportunity to use physical weed control through high-biomass, rolled cover crop mul...

  11. Glysphosate-resistant Palmer amaranth (Amaranthus palmeri) morphology,growth, and seed production in Georgia

    Science.gov (United States)

    Herbicide resistant Palmer amaranth has become the most economically detrimental weed of cotton in the Southeast US. With the continual marginalization of potential herbicide tools, research has expanded to include alternative means of affecting future Palmer amaranth populations by altering safe s...

  12. The Structure of PrPSc Prions

    Directory of Open Access Journals (Sweden)

    Holger Wille

    2018-02-01

    Full Text Available PrPSc (scrapie isoform of the prion protein prions are the infectious agent behind diseases such as Creutzfeldt–Jakob disease in humans, bovine spongiform encephalopathy in cattle, chronic wasting disease in cervids (deer, elk, moose, and reindeer, as well as goat and sheep scrapie. PrPSc is an alternatively folded variant of the cellular prion protein, PrPC, which is a regular, GPI-anchored protein that is present on the cell surface of neurons and other cell types. While the structure of PrPC is well studied, the structure of PrPSc resisted high-resolution determination due to its general insolubility and propensity to aggregate. Cryo-electron microscopy, X-ray fiber diffraction, and a variety of other approaches defined the structure of PrPSc as a four-rung β-solenoid. A high-resolution structure of PrPSc still remains to be solved, but the four-rung β-solenoid architecture provides a molecular framework for the autocatalytic propagation mechanism that gives rise to the alternative conformation of PrPSc. Here, we summarize the current knowledge regarding the structure of PrPSc and speculate about the molecular conversion mechanisms that leads from PrPC to PrPSc.

  13. Multiple-Herbicide Resistance Is Widespread in Roadside Palmer Amaranth Populations.

    Science.gov (United States)

    Bagavathiannan, Muthukumar V; Norsworthy, Jason K

    2016-01-01

    Herbicide-resistant Palmer amaranth is a widespread issue in row-crop production in the Midsouthern US. Palmer amaranth is commonly found on roadside habitats in this region, but little is known on the degree of herbicide resistance in these populations. Herbicide resistance in roadside Palmer amaranth populations can represent the spread of an adaptive trait across a selective landscape. A large-scale survey was carried out in the Mississippi Delta region of eastern Arkansas to document the level of resistance in roadside Palmer amaranth populations to pyrithiobac and glyphosate, two important herbicides with broad history of use in the region. A total of 215 Palmer amaranth populations collected across 500 random survey sites were used in the evaluations. About 89 and 73% of the surveyed populations showed >90% survival to pyrithiobac and glyphosate, respectively. Further, only 3% of the populations were completely susceptible to glyphosate, while none of the populations was completely controlled by pyrithiobac. Among the 215 populations evaluated, 209 populations showed multiple resistance to both pyrithiobac and glyphosate at varying degrees. Dose-response assays confirmed the presence of high levels of herbicide resistance in the five selected populations (≥ 25-fold compared to a susceptible standard). Results demonstrate the prevalence of multiple-herbicide resistance in roadside Palmer amaranth populations in this region. Growers should be vigilant of Palmer amaranth infestation in roadsides adjacent to their fields and implement appropriate control measures to prevent likely spread of herbicide resistance into their fields.

  14. Straight talk with... Carolyn Bertozzi. Interview by Roxanne Palmer.

    Science.gov (United States)

    Bertozzi, Carolyn

    2010-07-01

    Last month, Carolyn Bertozzi became the first woman to win the prestigious Massachusetts Institute of Technology (MIT)-Lemelson Prize, a $500,000 award that honors midcareer inventors. Bertozzi, a chemical biologist, works to understand how sugars mediate cell-to-cell communication. But she isn't content with just observing the process; her lab at the University of California-Berkeley has pioneered tools for labeling molecules inside living cells. Her biomedical inventions have contributed to the development of noninvasive methods for identifying disease tissue within the body-advances that could revolutionize both the diagnosis and the treatment of a host of diseases ranging from arthritis to cancer. Roxanne Palmer recently caught up with her by phone to discuss Bertozzi's sweet success with cell surface sugars.

  15. Palmer Classification and Magnetic Resonance Imaging Findings of Ulnocarpal Impingement.

    Science.gov (United States)

    Ersoy, Hale; Pomeranz, Stephen J

    2015-01-01

    Ulnocarpal impaction (UCI) syndrome is a well-recognized and relatively frequent cause of ulnar-sided wrist pain and limitation of motion. In the setting of negative or questionable negative radiographs and a strong clinical suspicion for UCI, magnetic resonance imaging (MRI) is helpful in detecting occult disease. Current MRI technology is capable of providing high-spatial-resolution images on multiple planes while manipulating contrast to highlight different tissue types. However, imaging of the triangular fibrocartilage complex has been challenging because of the small and complex components of this structure. In this article, the stages of UCI are discussed with illustrations of the spectrum of MRI findings using Palmer classification as a guideline.

  16. The Courage to Teach: Exploring the Inner Landscape of a Teacher's Life (by Parker J. Palmer)

    Science.gov (United States)

    Hurt Middlecamp, Reviewed By Catherine

    1999-12-01

    . Without putting the human factor into the teaching equation, you miss one of the key variables. In the early chapters, Palmer offers the readers simple statements to entice them to delve more deeply into his later discussions. "Good teaching cannot be reduced to technique; good teaching comes from the identity and integrity of the teacher," or, "Bad teachers distance themselves from the subject they are teaching - and in the process, from their students," or ultimately, "Only one resource is at my immediate command: my identity, my selfhood, my sense of this 'I' who teaches - without which I have no sense of the 'Thou' who learns." Readers can expect to find both ideas and a personal honesty on Palmer's part that inspires one to accept human limitations and evokes a gentle chuckle at our good days...and at our bad ones as well. Palmer has strong credentials to write about the self as teacher. In recent years, he has been a visiting faculty member at Beloit College, Berea College, and Georgetown University. Over past few decades, he has written extensively on the teaching and learning process, including To Know as We Are Known: Education as a Spiritual Journey (1983). He holds a Ph.D. from the University of California at Berkeley and has lived and taught in a variety of settings and communities around the globe. Woven through his writings is a sense of both the human and the spiritual dimensions of being a teacher. Thus, those who most might appreciate his reflections are comfortable with language drawn from spiritual traditions. Palmer spent a number of years as teacher and writer-in-residence at Pendle Hill, a Quaker community in Pennsylvania, and the respect and appreciation that he holds for silence and reflection come through in his writing. Expect to find no religious dogma or prescriptions in what he offers. What might those of us who teach chemistry expect to gain from this book? One possibility offered at the start is his examination of fear as a part of human

  17. Interference of Selected Palmer Amaranth (Amaranthus palmeri) Biotypes in Soybean (Glycine max)

    National Research Council Canada - National Science Library

    Chandi, Aman; Jordan, David L; York, Alan C; Milla-Lewis, Susana R; Burton, James D; Culpepper, A. Stanley; Whitaker, Jared R

    2012-01-01

      Palmer amaranth (Amaranthus palmeri S. Wats.) has become difficult to control in row crops due to selection for biotypes that are no longer controlled by acetolactate synthase inhibiting herbicides and/or glyphosate...

  18. Near-Earth Asteroid Lightcurve at CS3-Palmer Divide Station: 2017 April thru June

    Science.gov (United States)

    Warner, Brian D.

    2017-10-01

    Lightcurves for 31 near-Earth asteroids (NEAs) obtained at the Center for Solar System Studies-Palmer Divide Station (CS3-PDS) from 2017 April thru June were analyzed for rotation period and signs of satellites or tumbling.

  19. Integrated Palmer Amaranth Management in Glufosinate-Resistant Cotton: II. Primary, Secondary and Conservation Tillage

    Directory of Open Access Journals (Sweden)

    Michael G. Patterson

    2013-01-01

    Full Text Available A three year field experiment was conducted to evaluate the role of soil inversion, cover crops and spring tillage methods for Palmer amaranth between-row (BR and within-row (WR management in glufosinate-resistant cotton. Main plots were two soil inversion treatments: fall inversion tillage (IT and non-inversion tillage (NIT. Subplots were three cover treatments: crimson clover, cereal rye or none (i.e., winter fallow; and the sub subplots were four secondary spring tillage methods: disking followed by (fb cultivator (DCU, disking fb chisel plow (DCH, disking fb disking (DD and no tillage (NT. Averaged over years and soil inversion, the crimson clover produced maximum cover biomass (4390 kg ha−1 fb cereal rye (3698 kg ha−1 and winter fallow (777 kg ha−1. Two weeks after planting (WAP and before the postemergence (POST application, Palmer amaranth WR and BR density were two- and four-times less, respectively, in IT than NIT. Further, Palmer amaranth WR and BR density were reduced two-fold following crimson clover and cereal rye than following winter fallow at 2 WAP. Without IT, early season Palmer amaranth densities were 40% less following DCU, DCH and DD, when compared with IT. Following IT, no spring tillage method improved Palmer amaranth control. The timely application of glufosinate + S-metolachlor POST tank mixture greatly improved Palmer amaranth control in both IT and NIT systems. The highest cotton yields were obtained with DD following cereal rye (2251 kg ha−1, DD following crimson clover (2213 kg ha−1 and DD following winter fallow (2153 kg ha−1. On average, IT cotton yields (2133 kg ha−1 were 21% higher than NIT (1766 kg ha−1. Therefore, from an integrated weed management standpoint, an occasional fall IT could greatly reduce Palmer amaranth emergence on farms highly infested with glyphosate-resistant Palmer amaranth. In addition, a cereal rye or crimson clover cover crop can effectively reduce early season Palmer

  20. Recombinant PrPSc shares structural features with brain-derived PrPSc: Insights from limited proteolysis.

    Science.gov (United States)

    Sevillano, Alejandro M; Fernández-Borges, Natalia; Younas, Neelam; Wang, Fei; R Elezgarai, Saioa; Bravo, Susana; Vázquez-Fernández, Ester; Rosa, Isaac; Eraña, Hasier; Gil, David; Veiga, Sonia; Vidal, Enric; Erickson-Beltran, Melissa L; Guitián, Esteban; Silva, Christopher J; Nonno, Romolo; Ma, Jiyan; Castilla, Joaquín; R Requena, Jesús

    2018-01-01

    Very solid evidence suggests that the core of full length PrPSc is a 4-rung β-solenoid, and that individual PrPSc subunits stack to form amyloid fibers. We recently used limited proteolysis to map the β-strands and connecting loops that make up the PrPSc solenoid. Using high resolution SDS-PAGE followed by epitope analysis, and mass spectrometry, we identified positions ~116/118, 133-134, 141, 152-153, 162, 169 and 179 (murine numbering) as Proteinase K (PK) cleavage sites in PrPSc. Such sites likely define loops and/or borders of β-strands, helping us to predict the threading of the β-solenoid. We have now extended this approach to recombinant PrPSc (recPrPSc). The term recPrPSc refers to bona fide recombinant prions prepared by PMCA, exhibiting infectivity with attack rates of ~100%. Limited proteolysis of mouse and bank vole recPrPSc species yielded N-terminally truncated PK-resistant fragments similar to those seen in brain-derived PrPSc, albeit with varying relative yields. Along with these fragments, doubly N- and C-terminally truncated fragments, in particular ~89/97-152, were detected in some recPrPSc preparations; similar fragments are characteristic of atypical strains of brain-derived PrPSc. Our results suggest a shared architecture of recPrPSc and brain PrPSc prions. The observed differences, in particular the distinct yields of specific PK-resistant fragments, are likely due to differences in threading which result in the specific biochemical characteristics of recPrPSc. Furthermore, recombinant PrPSc offers exciting opportunities for structural studies unachievable with brain-derived PrPSc.

  1. A global dataset of self-calibrating Palmer Drought Severity Index dataset

    Science.gov (United States)

    van der Schrier, G.; Jones, P. D.; Briffa, K. R.

    2010-09-01

    Global maps of monthly self-calibrating Palmer Drought Severity Index (scPDSI) have been calculated for the period 1901-2009 with a spatial resolution of 0.5"× 0.5". The scPDSI is a convenient means of describing the spatial and temporal variability of moisture availability and is based on the more common Palmer Drought Severity Index. The scPDSI improves upon the Palmer Drought Severity Index by maintaining a consistent behaviour of the index over diverse climatological regions. This makes spatial comparisons of scPDSI values on continental scales more meaningful. Potential evapotranspiration (PET) is one of the inputs to the Palmer Drought Severity Index. This scPDSI dataset uses the realistic Penman-Monteith estimate for PET rather than the commonly used Thornthwaite method. In this presentation, the impact of using either one of these PET-estimates in calculated actual evapotranspiration and in the scPDSI values is assessed. The traditional Palmer Drought Severity Index assumes all precipitation to be in the liquid phase. To represent the impact of seasonal snow cover on the water budget, a simple snow accumulation and snow melt model is added to the waterbalance calculations on which the self-calibrating Palmer Drought Severity Index is based. The impact of this additional feature on estimates of the scPDSI is discussed. By substituting climatological monthly mean values for PET, from the period 1961-1990, for the actual monthly means of potential evaporation, an estimate is made of the direct effect of climate change, and in particular the increase in temperature, on drought. The scPDSI with these additional features (Penman PET and a simple snow-melt model) makes the calculations more realistic. It is hoped that they will be more widely used outside the United States, as the approach provides a very convenient means of online drought monitoring.

  2. Asteroid Lightcurve Analysis at CS3-Palmer Divide Station: 2017 July Through October

    Science.gov (United States)

    Warner, Brian D.

    2018-01-01

    Lightcurves for 17 main-belt asteroids were obtained at the Center for Solar System Studies-Palmer Divide Station (CS3-PDS) from 2017 July through October. All but two of the asteroids were targets of opportunity, i.e., in the field of planned targets, demonstrating a good reason for data mining images.

  3. Palmer amaranth (Amaranthus palmeri) damage niche in Illinois soybean is seed-limited

    Science.gov (United States)

    Palmer amaranth, a dioecious summer annual forb originating in Sonoran desert washes, compromises crop yields in much of the southern U.S., and is expanding its range northward. Appropriate tactics for proactively managing this weed in the upper Midwest will depend on characterizing its damage niche...

  4. Employing canopy hyperspectral narrowband data and random forest algorithm to differentiate palmer amaranth from colored cotton

    Science.gov (United States)

    Palmer amaranth (Amaranthus palmeri S. Wats.) invasion negatively impacts cotton (Gossypium hirsutum L.) production systems throughout the United States. The objective of this study was to evaluate canopy hyperspectral narrowband data as input into the random forest machine learning algorithm to dis...

  5. Structural studies of PrPSc

    OpenAIRE

    Vázquez Fernández, Ester

    2013-01-01

    Elucidation of the structure of PrPSc continues to be one major challenge in prion research. Molecular basis of the biology of prion protein, such as the molecular mechanism of prion replication and aggregation, the species barrier and the pathogenesis of neurodegeneration will not be understood until the structure is solved. Given that high-resolution techniques such as NMR or X-ray crystallography cannot be used, a number of lower resolution analytical approaches have been attempted.

  6. Plasminogen: A cellular protein cofactor for PrPSc propagation

    OpenAIRE

    Mays, Charles E; Ryou, Chongsuk

    2011-01-01

    The biochemical essence of prion replication is the molecular multiplication of the disease-associated misfolded isoform of prion protein (PrP), termed PrPSc, in a nucleic acid-free manner. PrPSc is generated by the protein misfolding process facilitated by conformational conversion of the host-encoded cellular PrP to PrPSc. Evidence suggests that an auxiliary factor may play a role in PrPSc propagation. We and others previously discovered that plasminogen interacts with PrP, while its functi...

  7. PSC Matrix for Active GSA Schedules and GSA GWACs

    Data.gov (United States)

    General Services Administration — The Product Service Codes (PSC) and North American Industrial Classification Systems (NAICS) are the two methods the Federal government classifies contracts. They...

  8. An integration-free, virus-free rhesus macaque induced pluripotent stem cell line (riPSC89 from embryonic fibroblasts

    Directory of Open Access Journals (Sweden)

    Enrique Sosa

    2016-09-01

    Full Text Available We generated a rhesus macaque induced pluripotent stem cell (riPSC line, riPSC89, from rhesus embryonic fibroblasts (REFs. Fibroblasts were expanded from the skin of a rhesus macaque embryo at embryonic day 47. REFs and riPSCs had a normal male (42, XY karyotype. The riPSC89 line was positive for markers of self-renewal including OCT4, NANOG, TRA-1-81 and SSEA4. Pluripotency was demonstrated through the generation of teratomas using transplantation into immunocompromised mice. The riPSC89 line may be a useful non-human primate resource to uncover developmental origins of disease, or used as a basic model to understand lineage specification in the primate embryo.

  9. Randomized double-blind trial to evaluate the effectiveness of topical administration of propylene glycol in arsenical palmer keratosis

    OpenAIRE

    Ashrafun Naher Dina and Mir Misbahuddin

    2010-01-01

    Keratosis, one of the earliest skin manifestations of arsenicosis, can be treated by either oral or topical formulation of drug. In this study we examined the effectiveness and tolerance of propylene glycol for the treatment of arsenical palmer keratosis. Sixty patients of arsenicosis with palmer keratoses were randomly divided into three groups and different concentrations (15, 30 and 45%) of propylene glycol were applied topically into their palms once at bedtime for eight weeks. The percep...

  10. Antarctic Holocene climate change: A benthic foraminiferal stable isotope record from Palmer Deep

    OpenAIRE

    Shevenell, A. E.; Kennett, J. P.

    2002-01-01

    The first moderate- to high-resolution Holocene marine stable isotope record from the nearshore Antarctic continental shelf (Ocean Drilling Program (ODP) Hole 1098B) suggests sensitivity of the western Antarctic Peninsula hydrography to westerly wind strength and El Nino-Southern Oscillation (ENSO)-like climate variability. Despite proximity to corrosive Antarctic water masses, sufficient CaCO3 in Palmer Deep sediments exists to provide a high-quality stable isotopic record (especially in the...

  11. PK-sensitive PrPSc is infectious and shares basic structural features with PK-resistant PrPSc

    Science.gov (United States)

    One of the main characteristics of the transmissible isoform of the prion protein (PrPSc) is its partial resistance to proteinase K (PK) digestion. Diagnosis of prion disease typically relies upon immunodetection of PK-digested PrPSc following Western blot or ELISA. More recently, researchers determ...

  12. Resources.

    Science.gov (United States)

    Stewart, John; MacDonald, Ian

    1980-01-01

    Presents a guide to resources on television drama available to teachers for classroom use in television curriculum. Lists American and British television drama videorecordings of both series and individual presentations and offers a bibliography of "one-off" single fiction plays produced for British television. (JMF)

  13. Inhibition of cholesterol recycling impairs cellular PrPSc propagation

    OpenAIRE

    Gilch, Sabine; Bach, Christian; Lutzny, Gloria; Vorberg, Ina; Sch?tzl, Hermann M.

    2009-01-01

    The infectious agent in prion diseases consists of an aberrantly folded isoform of the cellular prion protein (PrPc), termed PrPSc, which accumulates in brains of affected individuals. Studies on prion-infected cultured cells indicate that cellular cholesterol homeostasis influences PrPSc propagation. Here, we demonstrate that the cellular PrPSc content decreases upon accumulation of cholesterol in late endosomes, as induced by NPC-1 knock-down or treatment with U18666A. PrPc trafficking, lip...

  14. Infectivity-associated PrPSc and disease duration-associated PrPSc of mouse BSE prions

    Science.gov (United States)

    Miyazawa, Kohtaro; Okada, Hiroyuki; Masujin, Kentaro; Iwamaru, Yoshifumi; Yokoyama, Takashi

    2015-01-01

    ABSTRACT Disease-related prion protein (PrPSc), which is a structural isoform of the host-encoded cellular prion protein, is thought to be a causative agent of transmissible spongiform encephalopathies. However, the specific role of PrPSc in prion pathogenesis and its relationship to infectivity remain controversial. A time-course study of prion-affected mice was conducted, which showed that the prion infectivity was not simply proportional to the amount of PrPSc in the brain. Centrifugation (20,000 ×g) of the brain homogenate showed that most of the PrPSc was precipitated into the pellet, and the supernatant contained only a slight amount of PrPSc. Interestingly, mice inoculated with the obtained supernatant showed incubation periods that were approximately 15 d longer than those of mice inoculated with the crude homogenate even though both inocula contained almost the same infectivity. Our results suggest that a small population of fine PrPSc may be responsible for prion infectivity and that large, aggregated PrPSc may contribute to determining prion disease duration. PMID:26555211

  15. Tractable approximations for probabilistic models: The adaptive Thouless-Anderson-Palmer mean field approach

    DEFF Research Database (Denmark)

    Opper, Manfred; Winther, Ole

    2001-01-01

    We develop an advanced mean held method for approximating averages in probabilistic data models that is based on the Thouless-Anderson-Palmer (TAP) approach of disorder physics. In contrast to conventional TAP. where the knowledge of the distribution of couplings between the random variables...... is required. our method adapts to the concrete couplings. We demonstrate the validity of our approach, which is so far restricted to models with nonglassy behavior? by replica calculations for a wide class of models as well as by simulations for a real data set....

  16. Recombinant PrPSc shares structural features with brain-derived PrPSc suggesting that they have a similar architecture: Insights from limited proteolysis

    Science.gov (United States)

    An extensive body of experimental and spectroscopic evidence supports the hypothesis that PrPSc is a multimer of 4-rung ß-solenoids, and that individual PrPSc solenoids stack to form amyloid fibers. We recently used limited proteolysis to map the ß-strands and connecting loops that make up the PrPSc...

  17. Gunfight at the NOT OK Corral: Reply to "High Noon for Microfinance" by Duvendack and Palmer-Jones (Uncut version).

    Science.gov (United States)

    Pitt, Mark M

    2012-01-01

    The paper "High Noon for Microfinance Impact Evaluations" by Duvendack and Palmer-Jones replicates the papers of Chemin (2008) and Pitt and Khandker (1998) that estimate the impact of microfinance in Bangladesh. My paper replicates the Duvendack and Palmer-Jones replication and finds so many serious errors in their code and misrepresentations of the methods described in their paper that I conclude that their results are spurious and provide no evidence about the validity of either the papers of Chemin or Pitt and Khandker or on the effectiveness of microfinance.

  18. The new energy management policy: Indonesian PSC-gross-split applied on steam flooding project

    Science.gov (United States)

    Irham, S.; Julyus, P.

    2018-01-01

    “SIPY” oil field has been producing oil using steam flooding technology since 1992 under the PSC-Cost-Recovery policy. In 2021, the contract will be finished, and a new agreement must be submitted to the Indonesian government. There are two applied fiscal policies on oil and gas management: PSC-Cost-Recovery and PSC-Gross-Split (introduced in 2017 as the new energy management plan). The contractor must choose between PSC-Cost-Recovery and PSC-Gross-split which makes more profit. The aim of this research is to determine the best oil and gas contract policy for the contractor. The methods are calculating contractor cash flow and comparing the Profitability Indexes. The results of this study are (1) Net Present Values for the PSC-Cost-Recovery and the PSC-Gross-Split are 15 MMUS and 61 MMUS, respectively; and (2) Internal Rate of Return values for the PSC-Cost-Recovery and PSC-Gross-Split are 10% and 11%, respectively. The conclusion is that the Net Present Value and Internal Rate of Return of PSC-Gross-Split are greater than those of PSC-Cost-Recovery, but in Pay Out Time of PSC-Gross-split is longer than Pay Out Time in PSC-Cost-Recovery. Thus, the new energy management policy will be more attractive than PSC-Cost-Recovery.

  19. Firmeza de mangas 'Palmer' tratadas com 1-metilciclopropeno e armazenadas sob refrigeração Firmness of mangos 'Palmer' treated with 1-methylcyclopropene and stored under refrigeration

    Directory of Open Access Journals (Sweden)

    Ellen Toews Doll Hojo

    2007-12-01

    Full Text Available O objetivo do trabalho foi avaliar o efeito do 1-MCP na firmeza de mangas ´Palmer', armazenadas sob refrigeração. As mangas foram tratadas com 1-MCP nas concentrações de 0, 100 e 150nL.L-1, durante 12 horas à 22ºC. Em seguida, foram armazenadas em câmara fria a 10 ± 1ºC e 80 a 90% de UR, por um período de 35 dias. A cada 7 dias foram retirados 6 frutos de cada tratamento para as seguintes avaliações: firmeza, pectina total, percentagem de solubilização de pectinas, atividade da pectinametilesterase, poligalacturonase e â-D-galactosidase. O tratamento com 1-MCP, associado à refrigeração mostrou ser eficiente em prolongar a vida útil dos frutos. Os frutos tratados com 150nL.L-1 apresentaram menor percentagem de solubilização de pectina e mais firmes no final do armazenamento, quando comparados aos outros tratamentos. Após 35 dias de armazenamento refrigerado, todos os frutos estavam aptos para o consumo, indicando que outros estudos deverão ser realizados aumentando o tempo de armazenamento.The objective of this work was to evaluate the effect of the 1-MCP in the firmness of mangos ´Palmer' stored under refrigeration. The mangos were treated with 1-MCP in concentrations of 0, 100 and 150nL.L-1, during 12 hours at the 22ºC. Soon after, they were stored in a cold chamber (10 ± 1ºC and 80 to 90% of UR, for a period of 35 days. Every 7 days were retired 6 fruits of each treatment for to the following evaluations: firmness, total pectin, percentage of solubilization of pectins, activity of the pectinmethylesterase, polygalacturonase and â-D-galactosidase activities. The treatment with 1-MCP, associated to the refrigeration showed to be efficient in prolonging the useful life of the fruits. The treated fruits with 150nL.L-1 presented smaller percentage of pectin solubilization and firmness in the end of the storage, when compared to the other treatments. After 35 days of refrigerated storage, all the fruits were capable for

  20. Heterogeneity of the Abnormal Prion Protein (PrPSc) of the Chandler Scrapie Strain.

    Science.gov (United States)

    Kasai, Kazuo; Iwamaru, Yoshifumi; Masujin, Kentaro; Imamura, Morikazu; Mohri, Shirou; Yokoyama, Takashi

    2013-02-18

    The pathological prion protein, PrPSc, displays various sizes of aggregates. In this study, we investigated the conformation, aggregation stability and proteinase K (PK)-sensitivity of small and large PrPSc aggregates of mouse-adapted prion strains. We showed that small PrPSc aggregates, previously thought to be PK-sensitive, are resistant to PK digestion. Furthermore, we showed that small PrPSc aggregates of the Chandler scrapie strain have greater resistance to PK digestion and aggregation-denaturation than large PrPSc aggregates of this strain. We conclude that this strain consists of heterogeneous PrPSc.

  1. The N-terminal cleavage site of PrPSc from BSE differs from that of PrPSc from scrapie.

    Science.gov (United States)

    Hayashi, Hiroko K; Yokoyama, Takashi; Takata, Masuhiro; Iwamaru, Yoshifumi; Imamura, Morikazu; Ushiki, Yuko K; Shinagawa, Morikazu

    2005-03-25

    Heterogeneity in transmissible spongiform encephalopathy is thought to have derived from conformational variation in an abnormal isoform of the prion protein (PrPSc). To characterize PrPSc in bovine spongiform encephalopathy (BSE) and scrapie, we analyzed the newly generated N-terminus of PrPSc isoforms by digestion with proteinase K (PK). With a lower concentration of PK, the terminal amino acid of BSE PrPSc converged at N96. Under the same conditions, however, the terminal amino acid of scrapie PrPSc was G81 or G85. Furthermore, with an increase of PK concentration, the N-terminal amino acid was shifted and converged at G89. The results suggest that the PK cleavage site of BSE PrPSc is uniform and is different from the cleavage site of scrapie PrPSc.

  2. Generation of human iPSC line from a patient with laterality defects and associated congenital heart anomalies carrying a DAND5 missense alteration

    Directory of Open Access Journals (Sweden)

    Fernando Cristo

    2017-12-01

    Full Text Available A human iPSC line was generated from exfoliated renal epithelial (ERE cells of a patient affected with Congenital Heart Disease (CHD and Laterality Defects carrying tshe variant p.R152H in the DAND5 gene. The transgene-free iPSCs were generated with the human OSKM transcription factor using the Sendai-virus reprogramming system. The established iPSC line had the specific heterozygous alteration, a stable karyotype, expressed pluripotency markers and generated embryoid bodies that can differentiate towards the three germ layers in vitro. This iPSC line offers a useful resource to study the molecular mechanisms of cardiomyocyte proliferation, as well as for drug testing.

  3. Generation of a gene-corrected isogenic control cell line from an Alzheimer's disease patient iPSC line carrying a A79V mutation in PSEN1

    Directory of Open Access Journals (Sweden)

    Carlota Pires

    2016-09-01

    Full Text Available Alzheimer's disease (AD is a progressive and irreversible neurodegenerative disease causing neural cell degeneration and brain atrophy and is considered to be the most common form of dementia. We previously generated an induced pluripotent stem cell (iPSC line from an AD patient carrying an A79V mutation in PSEN1 as an in vitro disease model. Here we generated a gene-corrected version from this hiPSC line by substituting the point mutation with the wild-type sequence. The reported A79V-GC-iPSCs line is a very useful resource in combination with the A79V-iPSC line in order to study pathological cellular phenotypes related to this particular mutation.

  4. Human induced pluripotent stem cell (hiPSC)-derived neurons respond to convulsant drugs when co-cultured with hiPSC-derived astrocytes.

    Science.gov (United States)

    Ishii, Misawa Niki; Yamamoto, Koji; Shoji, Masanobu; Asami, Asano; Kawamata, Yuji

    2017-08-15

    Accurate risk assessment for drug-induced seizure is expected to be performed before entering clinical studies because of its severity and fatal damage to drug development. Induced pluripotent stem cell (iPSC) technology has allowed the use of human neurons and glial cells in toxicology studies. Recently, several studies showed the advantage of co-culture system of human iPSC (hiPSC)-derived neurons with rodent/human primary astrocytes regarding neuronal functions. However, the application of hiPSC-derived neurons for seizure risk assessment has not yet been fully addressed, and not at all when co-cultured with hiPSC-derived astrocytes. Here, we characterized hiPSC-derived neurons co-cultured with hiPSC-derived astrocytes to discuss how hiPSC-derived neurons are useful to assess seizure risk of drugs. First, we detected the frequency of spikes and synchronized bursts hiPSC-derived neurons when co-cultured with hiPSC-derived astrocytes for 8 weeks. This synchronized burst was suppressed by the treatment with 6-cyano-7-nitroquinoxaline-2,3-dione, α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor antagonist, and D-(-)-2-amino-5-phosphonopentanoic acid, an N-Methyl-d-aspartate (NMDA) receptor antagonist. These data suggested that co-cultured hiPSC-derived neurons formed synaptic connections mediated by AMPA and NMDA receptors. We also demonstrated that co-cultured hiPSC-derived neurons showed epileptiform activity upon treatment with gabazine or kaliotoxin. Finally, we performed single-cell transcriptome analysis in hiPSC-derived neurons and found that hiPSC-derived astrocytes activated the pathways involved in the activities of AMPA and NMDA receptor functions, neuronal polarity, and axon guidance in hiPSC-derived neurons. These data suggested that hiPSC-derived astrocytes promoted the development of action potential, synaptic functions, and neuronal networks in hiPSC-derived neurons, and then these functional alterations result in the epileptiform

  5. Did American social and economic events from 1865 to 1898 influence D.D. Palmer the chiropractor and entrepreneur?

    Science.gov (United States)

    Batinić, Josip; Skowron, Mirek; Hammerich, Karin

    2013-09-01

    This paper explores how the social landscape of the latter half of the nineteenth century influenced D. D. Palmer and the many occupations he pursued. It focuses on the geographical area where D. D. lived from 1865 to 1898. This paper will show how the American social and economic events of the time provided favourable circumstances for D.D.'s entrepreneurial successes.

  6. Seeing Double Old and New: Observations and Lightcurve Analysis at the Palmer Divide Observatory of Six Binary Asteroids

    Science.gov (United States)

    Warner, Brian D.

    2013-04-01

    Results of the analysis of lightcurves of six binary asteroids obtained at the Palmer Divide Observatory are reported. Of the six, three were previously known to be binary: 9069 Hovland, (26471) 2000 AS152, and 1994 XD. The remaining three are new confirmed or probable binary discoveries made at PDO: 2047 Smetana, (5646) 1990 TR, and (52316) 1992 BD.

  7. Inversion tillage, high residue covers, and different herbicide regimes for palmer amaranth control in liberty link systems

    Science.gov (United States)

    Glyphosate-resistant Palmer amaranth is adversely affecting cotton production in the Southeast US. A field experiment was established in fall 2008 at the E.V. Smith Research Center, Field Crops Unit near Shorter, AL, to investigate the role of inversion tillage, high residue cover crops, and differ...

  8. Characterization of animal models for primary sclerosing cholangitis (PSC).

    Science.gov (United States)

    Fickert, Peter; Pollheimer, Marion J; Beuers, Ulrich; Lackner, Carolin; Hirschfield, Gideon; Housset, Chantal; Keitel, Verena; Schramm, Christoph; Marschall, Hanns-Ulrich; Karlsen, Tom H; Melum, Espen; Kaser, Arthur; Eksteen, Bertus; Strazzabosco, Mario; Manns, Michael; Trauner, Michael

    2014-06-01

    Primary sclerosing cholangitis (PSC) is a chronic cholangiopathy characterized by biliary fibrosis, development of cholestasis and end stage liver disease, high risk of malignancy, and frequent need for liver transplantation. The poor understanding of its pathogenesis is also reflected in the lack of effective medical treatment. Well-characterized animal models are utterly needed to develop novel pathogenetic concepts and study new treatment strategies. Currently there is no consensus on how to evaluate and characterize potential PSC models, which makes direct comparison of experimental results and effective exchange of study material between research groups difficult. The International Primary Sclerosing Cholangitis Study Group (IPSCSG) has therefore summarized these key issues in a position paper proposing standard requirements for the study of animal models of PSC. Copyright © 2014 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

  9. Psychosocial safety climate as a lead indicator of workplace bullying and harassment, job resources, psychological health and employee engagement.

    Science.gov (United States)

    Law, Rebecca; Dollard, Maureen F; Tuckey, Michelle R; Dormann, Christian

    2011-09-01

    Psychosocial safety climate (PSC) is defined as shared perceptions of organizational policies, practices and procedures for the protection of worker psychological health and safety, that stem largely from management practices. PSC theory extends the Job Demands-Resources (JD-R) framework and proposes that organizational level PSC determines work conditions and subsequently, psychological health problems and work engagement. Our sample was derived from the Australian Workplace Barometer project and comprised 30 organizations, and 220 employees. As expected, hierarchical linear modeling showed that organizational PSC was negatively associated with workplace bullying and harassment (demands) and in turn psychological health problems (health impairment path). PSC was also positively associated with work rewards (resources) and in turn work engagement (motivational path). Accordingly, we found that PSC triggered both the health impairment and motivational pathways, thus justifying extending the JD-R model in a multilevel way. Further we found that PSC, as an organization-based resource, moderated the positive relationship between bullying/harassment and psychological health problems, and the negative relationship between bullying/harassment and engagement. The findings provide evidence for a multilevel model of PSC as a lead indicator of workplace psychosocial hazards (high demands, low resources), psychological health and employee engagement, and as a potential moderator of psychosocial hazard effects. PSC is therefore an efficient target for primary and secondary intervention. Copyright © 2011 Elsevier Ltd. All rights reserved.

  10. Immunogenicity and functional evaluation of iPSC-derived organs for transplantation.

    Science.gov (United States)

    Wang, Libin; Cao, Jiani; Wang, Yukai; Lan, Tianshu; Liu, Lei; Wang, Weixu; Jin, Ning; Gong, Jiaqi; Zhang, Chao; Teng, Fei; Yan, Guoliang; Li, Chun; Li, Jiali; Wan, Haifeng; Hu, Baoyang; Li, Wei; Zhao, Xiaoyang; Qi, Zhongquan; Zhao, Tongbiao; Zhou, Qi

    2015-01-01

    Whether physiologically induced pluripotent stem cell (iPSC)-derived organs are immunogenic and can be used for transplantation is unclear. Here, we generated iPSC-derived skin, islet, and heart representing three germ layers of the body through 4n complementation and evaluated their immunogenicity and therapeutic efficacy. Upon transplantation into recipient mice, iPSC-derived skin successfully survived and repaired local tissue wounds. In diabetic mouse models, explanted iPSC-derived islets effectively produced insulin and lowered blood glucose to basal levels. iPSC-derived heart grafts maintained normal beating for more than 3 months in syngeneic recipients. Importantly, no obvious immune rejection responses against iPSC-derived organs were detected long after transplantation. Our study not only demonstrates the fundamental immunogenicity and function of iPSC derivatives, but also provides preclinical evidence to support the feasibility of using iPSC-derived skin, islet, and heart for therapeutic use.

  11. Asteroid Lightcurve Analysis at the Palmer Divide Observatory: 2012 September - 2013 January

    Science.gov (United States)

    Warner, Brian D.

    2013-04-01

    Lightcurves for 40 asteroids were obtained at the Palmer Divide Observatory (PDO) from 2012 September to 2013 January: 495 Eulalia, 1694 Kaiser, 2001 Einstein, 3086 Kalbaugh, 3635 Kreutz, 5806 Archieroy, 6310 Jankonke, 6447 Terrycole, 6744 Komoda, 7086 Bopp, 7560 Spudis, 8325 Trigo-Rodriguez, 11149 Tateshina, 11709 Eudoxos, (13245) 1998 MM19, (13573) 1993 FZ18, 14395 Tommorgan, 15434 Mittal, (17657) 1996 VO4, (22013) 1999 XO89, (26916) 1996 RR2, 27776 Cortland, (30878) 1992 GQ, (30981) 1995 SJ4, (31831) 1999 YL, (32626) 2001 RX64, (51371) 2000 XF15, 55844 Bicak, (55854) 1996 VS1, (63440) 2001 MD30, (66832) 1999 UE45, (70927) 1999 VX210, (72675) 2001 FP54, (86388) 2000 AT60, (90988) 1997 XS13, (123937) 2001 EX16, (136017) 2002 VH74, (192683) 1999 SO27, (330825) 2008 XE3, and 2012 TC4. Based on data and analysis in 2012 for 27776 Cortland, the previously reported period from 2009 has been revised.

  12. About the book by Riitta V. Lahtinen and Russ C. Palmer. The Body Story

    Directory of Open Access Journals (Sweden)

    Salomatina I.V.

    2012-12-01

    Full Text Available The study carried out by a married couple, specialists in the sphere of deafblindness (one of whom has got an Usher syndrome, is devoted to the development of means of non-verbal communication and music perception for people with double sensory defect — deafblindness. Russ Palmer is a professional musician who had lost his hearing capacity under the influence of Usher syndrome. At present together with his wife he is inventing new ways of widening the contacts with the external world for people who found themselves in the same difficult situation. The authors of the book prove that any welfare item like a pillow or a toy balloon can sometimes dramatically change the situation for better.

  13. The new management policy: Indonesian PSC-Gross split applied on CO2 flooding project

    Science.gov (United States)

    Irham, S.; Sibuea, S. N.; Danu, A.

    2018-01-01

    “SIAD” oil field will be developed by CO2 flooding. CO2, a famous pollutant gas, is injected into the oil reservoir to optimize the oil recovery. This technique should be conducted economically according to the energy management policy in Indonesia. In general, Indonesia has two policy contracts on oil and gas: the old one is PSC-Cost-Recovery, and the new one is PSC-Gross-Split (introduced in 2017 as the new energy management plan). The contractor must choose between PSC-Cost-Recovery and PSC-Gross-Split which makes more profit. The aim of this paper is to show the best oil and gas contract policy for the contractor. The methods are calculating and comparing the economic indicators. The result of this study are (1) NPV for the PSC-Cost-Recovery is -46 MUS, while for the PSC-Gross-Split is 73 MUS, and (2) IRR for the PSC-Cost-Recovery is 9%, whereas for the PSC-Gross-Split is 11%. The conclusion is that the NPV and IRR for PSC-Gross-Split are greater than the NPV and IRR of PSC-Cost-Recovery, but POT in PSC-Gross-split is longer than POT in PSC-Cost-Recovery. Thus, in this case, the new energy policy contract can be applied for CO2 flooding technology since it yields higher economic indicators than its antecendent.

  14. hiPSC Disease Modeling of Rare Hereditary Cerebellar Ataxias.

    Science.gov (United States)

    Lukovic, Dunja; Moreno-Manzano, Victoria; Rodriguez-Jimenez, Francisco Javier; Vilches, Angel; Sykova, Eva; Jendelova, Pavla; Stojkovic, Miodrag; Erceg, Slaven

    2016-10-01

    Cerebellar ataxias are clinically and genetically heterogeneous diseases affecting primary cerebellar cells. The lack of availability of affected tissue from cerebellar ataxias patients is the main obstacle in investigating the pathogenicity of these diseases. The landmark discovery of human-induced pluripotent stem cells (hiPSC) has permitted the derivation of patient-specific cells with an unlimited self-renewing capacity. Additionally, their potential to differentiate into virtually any cell type of the human organism allows for large amounts of affected cells to be generated in culture, converting this hiPSC technology into a revolutionary tool in the study of the mechanisms of disease, drug discovery, and gene correction. In this review, we will summarize the current studies in which hiPSC were utilized to study cerebellar ataxias. Describing the currently available 2D and 3D hiPSC-based cellular models, and due to the fact that extracerebellar cells were used to model these diseases, we will discuss whether or not they represent a faithful cellular model and whether they have contributed to a better understanding of disease mechanisms.

  15. 9+ Years of CALIOP PSC Data: An Evolving Climatology

    Science.gov (United States)

    Pitts, Michael C.; Poole, Lamont R.

    2015-01-01

    Polar stratospheric clouds (PSCs) play key roles in the springtime chemical depletion of ozone at high latitudes. PSC particles provide sites for heterogeneous chemical reactions that transform stable chlorine and bromine reservoir species into highly reactive ozone-destructive forms. Furthermore, large nitric acid trihydrate (NAT) PSC particles can irreversibly redistribute odd nitrogen through gravitational sedimentation, which prolongs the ozone depletion process by slowing the reformation of the stable chlorine reservoirs. However, there are still significant gaps in our understanding of PSC processes, particularly concerning the details of NAT particle formation. Spaceborne observations from the CALIOP (Cloud-Aerosol Lidar with Orthogonal Polarization) lidar on the CALIPSO (Cloud-Aerosol Lidar and Infrared Pathfinder Satellite Observations) satellite are providing a rich new dataset for studying PSCs on unprecedented vortex-wide scales. In this paper, we examine the vertical and spatial distribution of PSCs in the Antarctic and Arctic on vortex-wide scales for entire PSC seasons over the more than nine-year data record.

  16. Human iPSC-Derived Endothelial Cell Sprouting Assay in ...

    Science.gov (United States)

    Activation of vascular endothelial cells (ECs) by growth factors initiates a cascade of events in vivo consisting of EC tip cell selection, sprout formation, EC stalk cell proliferation, and ultimately vascular stabilization by support cells. Although EC functional assays can recapitulate one or more aspects of angiogenesis in vitro, they are often limited by a lack of definition to the substratum and lack of dependence on key angiogenic signaling axes. Here, we designed and characterized a chemically-defined model of endothelial sprouting behavior in vitro using human induced pluripotent stem cell-derived endothelial cells (iPSC-ECs). Thiol-ene photopolymerization was used to rapidly encapsulate iPSC-ECs at high density in poly(ethylene glycol) (PEG) hydrogel spheres and subsequently to rapidly encapsulate iPSC-EC-containing hydrogel spheres in a cell-free over-layer. The hydrogel sprouting array here maintained pro-angiogenic phenotype of iPSC-ECs and supported growth factor-dependent proliferation and sprouting behavior. The sprouting model responded appropriately to several reference pharmacological angiogenesis inhibitors, which suggests the functional role of vascular endothelial growth factor, NF-κB, matrix metalloproteinase-2/9, protein kinase activity, and β-tubulin in endothelial sprouting. A blinded screen of 38 putative vascular disrupting compounds (pVDCs) from the US Environmental Protection Agency’s ToxCast library identified five compounds th

  17. Comparative effects of Potash Sodium Chloride (PSC) mixture and ...

    African Journals Online (AJOL)

    Honey (Mellifica sp) is produced by Apis mellifera africana, widely consumed without prescription or restriction, and has been shown to possess wound healing and antitusive properties. Comparative study of the effects of honey paste and Potash Sodium Chloride (PSC) mixture on the healing of incisional wound on albino ...

  18. Chromatin modification by PSC occurs at one PSC per nucleosome and does not require the acidic patch of histone H2A.

    Directory of Open Access Journals (Sweden)

    Stanley M Lo

    Full Text Available Chromatin architecture is regulated through both enzymatic and non-enzymatic activities. For example, the Polycomb Group (PcG proteins maintain developmental gene silencing using an array of chromatin-based mechanisms. The essential Drosophila PcG protein, Posterior Sex Combs (PSC, compacts chromatin and inhibits chromatin remodeling and transcription through a non-enzymatic mechanism involving nucleosome bridging. Nucleosome bridging is achieved through a combination of nucleosome binding and self-interaction. Precisely how PSC interacts with chromatin to bridge nucleosomes is not known and is the subject of this work. We determine the stoichiometry of PSC-chromatin interactions in compact chromatin (in which nucleosomes are bridged using Scanning Transmission Electron Microscopy (STEM. We find that full compaction occurs with one PSC per nucleosome. In addition to compacting chromatin, we show that PSC oligomerizes nucleosome arrays. PSC-mediated oligomerization of chromatin occurs at similar stoichiometry as compaction suggesting it may also involve nucleosome bridging. Interactions between the tail of histone H4 and the acidic patch of histone H2A are important for chromatin folding and oligomerization, and several chromatin proteins bind the histone H2A acidic patch. However, mutation of the acidic patch of histone H2A does not affect PSC's ability to inhibit chromatin remodeling or bridge nucleosomes. In fact, PSC does not require nucleosomes for bridging activity but can bridge naked DNA segments. PSC clusters nucleosomes on sparsely assembled templates, suggesting it interacts preferentially with nucleosomes over bare DNA. This may be due to the ability of PSC to bind free histones. Our data are consistent with a model in which each PSC binds a nucleosome and at least one other PSC to directly bridge nucleosomes and compact chromatin, but also suggest that naked DNA can be included in compacted structures. We discuss how our data

  19. In-depth characterisation of Retinal Pigment Epithelium (RPE) cells derived from human induced pluripotent stem cells (hiPSC).

    Science.gov (United States)

    Brandl, Caroline; Zimmermann, Stephanie J; Milenkovic, Vladimir M; Rosendahl, Sibylle M G; Grassmann, Felix; Milenkovic, Andrea; Hehr, Ute; Federlin, Marianne; Wetzel, Christian H; Helbig, Horst; Weber, Bernhard H F

    2014-09-01

    Induced pluripotent stem cell (iPSC)-derived retinal pigment epithelium (RPE) has widely been appreciated as a promising tool to model human ocular disease emanating from primary RPE pathology. Here, we describe the successful reprogramming of adult human dermal fibroblasts to iPSCs and their differentiation to pure expandable RPE cells with structural and functional features characteristic for native RPE. Fibroblast cultures were established from skin biopsy material and subsequently reprogrammed following polycistronic lentiviral transduction with OCT4, SOX2, KLF4 and L-Myc. Fibroblast-derived iPSCs showed typical morphology, chromosomal integrity and a distinctive stem cell marker profile. Subsequent differentiation resulted in expandable pigmented hexagonal RPE cells. The cells revealed stable RNA expression of mature RPE markers RPE65, RLBP and BEST1. Immunolabelling verified localisation of BEST1 at the basolateral plasma membrane, and scanning electron microscopy showed typical microvilli at the apical side of iPSC-derived RPE cells. Transepithelial resistance was maintained at high levels during cell culture indicating functional formation of tight junctions. Secretion capacity was demonstrated for VEGF-A. Feeding of porcine photoreceptor outer segments revealed the proper ability of these cells for phagocytosis. IPSC-derived RPE cells largely maintained these properties after cryopreservation. Together, our study underlines that adult dermal fibroblasts can serve as a valuable resource for iPSC-derived RPE with characteristics highly reminiscent of true RPE cells. This will allow its broad application to establish cellular models for RPE-related human diseases.

  20. Simulation of polar stratospheric clouds in the chemistry-climate-model EMAC via the submodel PSC

    Directory of Open Access Journals (Sweden)

    O. Kirner

    2011-03-01

    Full Text Available The submodel PSC of the ECHAM5/MESSy Atmospheric Chemistry model (EMAC has been developed to simulate the main types of polar stratospheric clouds (PSC. The parameterisation of the supercooled ternary solutions (STS, type 1b PSC in the submodel is based on Carslaw et al. (1995b, the thermodynamic approach to simulate ice particles (type 2 PSC on Marti and Mauersberger (1993. For the formation of nitric acid trihydrate (NAT particles (type 1a PSC two different parameterisations exist. The first is based on an instantaneous thermodynamic approach from Hanson and Mauersberger (1988, the second is new implemented and considers the growth of the NAT particles with the aid of a surface growth factor based on Carslaw et al. (2002. It is possible to choose one of this NAT parameterisation in the submodel. This publication explains the background of the submodel PSC and the use of the submodel with the goal of simulating realistic PSC in EMAC.

  1. Palmerín de Olivia como enmienda del modelo amadisiano: El rechazo de la perfección arquetípica

    Directory of Open Access Journals (Sweden)

    Martín Romero, José Julio

    2014-12-01

    Full Text Available In Palmerín de Olivia, the first of the imitations of Amadís de Gaula, some differences from the amadisian paradigm can already be traced. Thus, Palmerín, a heroe whose behaviour is almost always exemplary, sometimes shows some weaknesses that make him more human and that distinguish this character from the archetypical perfection of Amadís. This article traces and points out these unknightly behaviours of Palmerín and analyses them as features that distinguish this book from its model. As a result, this study provides new data on the configuration and diversity of the chivalric romance as a genre.Ya en Palmerín de Olivia, la primera de las imitaciones de Amadís de Gaula, se detectan diferencias frente al paradigma amadisiano. Así, Palmerín, un héroe cuyo comportamiento es casi siempre ejemplar, en varias ocasiones revela debilidades que lo humanizan y que lo alejan de la perfección arquetípica de Amadís. El presente artículo rastrea y señala esos comportamientos poco caballerescos de Palmerín y los analiza como rasgos que singularizan este libro de caballerías frente a su modelo. Como resultado de todo esto, el presente estudio arroja luz sobre la configuración del género caballeresco y ayuda a comprender su heterogeneidad.

  2. Isolation and characterization of a proteinase K-sensitive PrPSc fraction.

    Science.gov (United States)

    Pastrana, Miguel A; Sajnani, Gustavo; Onisko, Bruce; Castilla, Joaquín; Morales, Rodrigo; Soto, Claudio; Requena, Jesús R

    2006-12-26

    Recent studies have shown that a sizable fraction of PrPSc present in prion-infected tissues is, contrary to previous conceptions, sensitive to digestion by proteinase K (PK). This finding has important implications in the context of diagnosis of prion disease, as PK has been extensively used in attempts to distinguish between PrPSc and PrPC. Even more importantly, PK-sensitive PrPSc (sPrPSc) might be essential to understand the process of conversion and aggregation of PrPC leading to infectivity. We have isolated a fraction of sPrPSc. This material was obtained by differential centrifugation at an intermediate speed of Syrian hamster PrPSc obtained through a conventional procedure based on ultracentrifugation in the presence of detergents. PK-sensitive PrPSc is completely degraded under standard conditions (50 mug/mL of proteinase K at 37 degrees C for 1 h) and can also be digested with trypsin. Centrifugation in a sucrose gradient showed sPrPSc to correspond to the lower molecular weight fractions of the continuous range of oligomers that constitute PrPSc. PK-sensitive PrPSc has the ability to convert PrPC into protease-resistant PrPSc, as assessed by the protein misfolding cyclic amplification assay (PMCA). Limited proteolysis of sPrPSc using trypsin allows for identification of regions that are particularly susceptible to digestion, i.e., are partially exposed and flexible; we have identified as such the regions around residues K110, R136, R151, K220, and R229. PK-sensitive PrPSc isolates should prove useful for structural studies to help understand fundamental issues of the molecular biology of PrPSc and in the quest to design tests to detect preclinical prion disease.

  3. Did American social and economic events from 1865 to 1898 influence D.D. Palmer the chiropractor and entrepreneur?

    Science.gov (United States)

    Batinić, Josip; Skowron, Mirek; Hammerich, Karin

    2013-01-01

    This paper explores how the social landscape of the latter half of the nineteenth century influenced D. D. Palmer and the many occupations he pursued. It focuses on the geographical area where D. D. lived from 1865 to 1898. This paper will show how the American social and economic events of the time provided favourable circumstances for D.D.’s entrepreneurial successes. PMID:23997248

  4. Randomized double-blind trial to evaluate the effectiveness of topical administration of propylene glycol in arsenical palmer keratosis

    Directory of Open Access Journals (Sweden)

    Ashrafun Naher Dina

    2010-06-01

    Full Text Available Keratosis, one of the earliest skin manifestations of arsenicosis, can be treated by either oral or topical formulation of drug. In this study we examined the effectiveness and tolerance of propylene glycol for the treatment of arsenical palmer keratosis. Sixty patients of arsenicosis with palmer keratoses were randomly divided into three groups and different concentrations (15, 30 and 45% of propylene glycol were applied topically into their palms once at bedtime for eight weeks. The perception of the patient about the progress of treatment was scored with “Likert scale”. The mean (±SD score of patient’s perception following completion of treatment were 1.27 ± 1.26 (using 15% propylene glycol, 2.88 ± 1.26 (30% propylene glycol, and 3.75 ± 1.06 (45% propylene glycol respectively. The scores increased with higher concentra-tions. Thirty percent or more concentration of propylene glycol was effective for mild to severe form of keratosis. Propylene glycol was well tolerable. In conclusion, both roughness and thickness of arsenical palmer keratosis can be reduced using propylene glycol and as the concentration of the drug increases it increases its effectiveness without any significant adverse effect.

  5. Near-Earth Asteroid Lightcurve Analysis at CS3-Palmer Divide Station: 2017 July Through October

    Science.gov (United States)

    Warner, Brian D.

    2018-01-01

    Lightcurves for 37 near-Earth asteroids (NEAs) obtained at the Center for Solar System Studies-Palmer Divide Station (CS3-PDS) from 2017 July through October were analyzed for rotation period and signs of satellites or tumbling. (6053) 1993 BW3 was found to have an ambiguous solution that was resolved to 2.5737 h by using split-halves plots (see Harris et al., 2014). Data from 2016 for (141354) 2002 AJ29 were re-examined in light of new, independent results (Vaduvescu et al., 2017; 10.754 h). The 2016 data now lead to a revised period of 10.801 h. Recent results for (12538) 1998 OH by Vaduvescu et al. (2017, 2.58 h) prompted a reexamination of CS3 data from 2014 and 2016 with the result that the more recent period of 5.151 h (Warner, 2017a) is still more likely correct. Analysis of (66146) 1998 TU3 indicates it is a possible binary asteroid with P1 = 2.37760 h and PORB = 13.58 h. 2012 TC4 and 2017 NH were both found to be tumbling asteroids with short periods and large amplitudes.

  6. Effects of Lead on Ultrastructure of Isoetes sinensis Palmer (Isoetaceae, a Critically Endangered Species in China.

    Directory of Open Access Journals (Sweden)

    Guohua Ding

    Full Text Available Isoetes sinensis Palmer (Isoetaceae is a critically endangered fern that is a marsh plant (that is an aquatic or amphibious plant in China. To evaluate damage or influence of lead (Pb on cell ultrastructure in I. sinensis, we used 2000mg·L-1 Pb(NO32 solution to treat I. sinensis for 35d, and used transmission electron microscope (TEM to observe the cell ultrastructure of leaf blades and roots of the plant. Our results indicated that Pb induced distinct changes of the organelles including chloroplast, mitochondria, nucleolus and vacuole. The level of damage organ was lower leaf > upper leaf > root The typical performance of the damages caused by lead shown that part of the nucleolus cracked; the cristae dilated, matrix vacuolized and membrane structure blurred in mitochondria; the vacuole cracked; grana lamella decreased, stroma lamella loosed, starch grains decreased, and membrane structure was disrupted in chloroplasts; Pb deposits were present on cell wall. The damages to chloroplasts and mitochondria were relatively severe, while damage to the nucleus was relatively lighter. The damage to the cell ultrastructure of leaf blades with direct contact with Pb was more severe than that without direct contact with Pb.

  7. Joint spatiotemporal variability of global sea surface temperatures and global Palmer drought severity index values

    Science.gov (United States)

    Apipattanavis, S.; McCabe, G.J.; Rajagopalan, B.; Gangopadhyay, S.

    2009-01-01

    Dominant modes of individual and joint variability in global sea surface temperatures (SST) and global Palmer drought severity index (PDSI) values for the twentieth century are identified through a multivariate frequency domain singular value decomposition. This analysis indicates that a secular trend and variability related to the El Niño–Southern Oscillation (ENSO) are the dominant modes of variance shared among the global datasets. For the SST data the secular trend corresponds to a positive trend in Indian Ocean and South Atlantic SSTs, and a negative trend in North Pacific and North Atlantic SSTs. The ENSO reconstruction shows a strong signal in the tropical Pacific, North Pacific, and Indian Ocean regions. For the PDSI data, the secular trend reconstruction shows high amplitudes over central Africa including the Sahel, whereas the regions with strong ENSO amplitudes in PDSI are the southwestern and northwestern United States, South Africa, northeastern Brazil, central Africa, the Indian subcontinent, and Australia. An additional significant frequency, multidecadal variability, is identified for the Northern Hemisphere. This multidecadal frequency appears to be related to the Atlantic multidecadal oscillation (AMO). The multidecadal frequency is statistically significant in the Northern Hemisphere SST data, but is statistically nonsignificant in the PDSI data.

  8. Resistance to PPO‐inhibiting herbicide in Palmer amaranth from Arkansas

    Science.gov (United States)

    Salas, Reiofeli A; Tranel, Patrick J; Singh, Shilpa; Glasgow, Les; Scott, Robert C; Nichols, Robert L

    2016-01-01

    Abstract BACKGROUND The widespread occurrence of ALS inhibitor‐ and glyphosate‐resistant Amaranthus palmeri has led to increasing use of protoporphyrinogen oxidase (PPO)‐inhibiting herbicides in cotton and soybean. Studies were conducted to confirm resistance to fomesafen (a PPO inhibitor), determine the resistance frequency, examine the resistance profile to other foliar‐applied herbicides and investigate the resistance mechanism of resistant plants in a population collected in 2011 (AR11‐LAW B) and its progenies from two cycles of fomesafen selection (C1 and C2). RESULTS The frequency of fomesafen‐resistant plants increased from 5% in the original AR11‐LAW‐B to 17% in the C2 population. The amounts of fomesafen that caused 50% growth reduction were 6‐, 13‐ and 21‐fold greater in AR11‐LAW‐B, C1 and C2 populations, respectively, than in the sensitive ecotype. The AR11‐LAW‐B population was sensitive to atrazine, dicamba, glufosinate, glyphosate and mesotrione but resistant to ALS‐inhibiting herbicides pyrithiobac and trifloxysulfuron. Fomesafen survivors from C1 and C2 populations tested positive for the PPO glycine 210 deletion previously reported in waterhemp (Amaranthus tuberculatus). CONCLUSION These studies confirmed that Palmer amaranth in Arkansas has evolved resistance to foliar‐applied PPO‐inhibiting herbicide. © 2016 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry. PMID:26817647

  9. Inheritance of Evolved Glyphosate Resistance in a North Carolina Palmer Amaranth (Amaranthus palmeri Biotype

    Directory of Open Access Journals (Sweden)

    Aman Chandi

    2012-01-01

    Full Text Available Inheritance of glyphosate resistance in a Palmer amaranth biotype from North Carolina was studied. Glyphosate rates for 50% survival of glyphosate-resistant (GR and glyphosate-susceptible (GS biotypes were 1288 and 58 g ha−1, respectively. These values for F1 progenies obtained from reciprocal crosses (GR×GS and GS×GR were 794 and 501 g ha−1, respectively. Dose response of F1 progenies indicated that resistance was not fully dominant over susceptibility. Lack of significant differences between dose responses for reciprocal F1 families suggested that genetic control of glyphosate resistance was governed by nuclear genome. Analysis of F1 backcross (BC1F1 families showed that 10 and 8 BC1F1 families out of 15 fitted monogenic inheritance at 2000 and 3000 g ha−1 glyphosate, respectively. These results indicate that inheritance of glyphosate resistance in this biotype is incompletely dominant, nuclear inherited, and might not be consistent with a single gene mechanism of inheritance. Relative 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS copy number varied from 22 to 63 across 10 individuals from resistant biotype. This suggested that variable EPSPS copy number in the parents might be influential in determining if inheritance of glyphosate resistance is monogenic or polygenic in this biotype.

  10. UBV photometry of the Ap variable UZ Psc = HD 10783

    Science.gov (United States)

    Hardie, Robert H.; Reichmann, Edwin J.; Burke, Edward W., Jr.; Hall, Douglas S.

    1990-01-01

    The photometric variability of the Ap star HD 10783 = UZ Psc is discussed. New UBV photometry, obtained between late 1965 and early 1969, is presented and it is combined with existing published photometry to derive an improved ephemeris for times of maximum brightness: 2439758.00 + 4d.1328 n. It is concluded that the results are not very sensitive to the small shifts applied to the blue photometry.

  11. 9+ Years of CALIPSO PSC Observations: An Evolving Climatology

    Science.gov (United States)

    Pitts, Michael C.; Poole, Lamont R.

    2015-01-01

    Polar stratospheric clouds (PSCs) play a crucial role in the springtime chemical depletion of ozone at high latitudes. PSC particles (primarily supercooled ternary solution, or STS droplets) provide sites for heterogeneous chemical reactions that transform stable chlorine and bromine reservoir species into highly reactive ozone-destructive forms. Furthermore, large nitric acid trihydrate (NAT) PSC particles can irreversibly redistribute odd nitrogen through gravitational sedimentation (a process commonly known as denitrification), which prolongs the ozone depletion process by slowing the reformation of the stable chlorine reservoirs. Spaceborne observations from the CALIOP (Cloud-Aerosol Lidar with Orthogonal Polarization) lidar on the CALIPSO (Cloud-Aerosol Lidar and Infrared Pathfinder Satellite Observations) satellite are providing a rich new dataset for studying PSCs. CALIPSO is an excellent platform for studying polar processes with CALIOP acquiring, on average, over 300,000 backscatter profiles daily at latitudes between 55o and 82o in both hemispheres. PSCs are detected in the CALIOP backscatter profiles using a successive horizontal averaging scheme that enables detection of strongly scattering PSCs (e.g., ice) at the finest possible spatial resolution (5 km), while enhancing the detection of very tenuous PSCs (e.g., low number density NAT) at larger spatial scales (up to 135 km). CALIOP PSCs are separated into composition classes (STS; liquid/NAT mixtures; and ice) based on the ensemble 532-nm scattering ratio (the ratio of total-to-molecular backscatter) and 532-nm particulate depolarization ratio (which is sensitive to the presence of non-spherical, i.e. NAT and ice particles). In this paper, we will provide an overview of the CALIOP PSC detection and composition classification algorithm and then examine the vertical and spatial distribution of PSCs in the Arctic and Antarctic on vortex-wide scales for entire PSC seasons over the more than nine-year data

  12. EDITORIAL: Richard Palmer: celebrating 37 years with Journal of Physics: Condensed Matter Richard Palmer: celebrating 37 years with Journal of Physics: Condensed Matter

    Science.gov (United States)

    Ferry, David

    2009-01-01

    It is with a great deal of both happiness and sadness that I have to announce that we are losing one of the real strengths of the Journal of Physics: Condensed Matter (JPCM). Dr Richard Palmer, our Senior Publisher, announced his retirement, and this issue marks the first without his involvement. Of course, we are happy that he will get to enjoy his retirement, but we are sad to lose such a valuable member of our team. Richard first started work at IOP Publishing in March 1971 as an Editorial Assistant with Journal of Physics B: Atomic and Molecular Physics. After a few months, he transferred to Journal of Physics C: Solid State Physics. During his first year, he was sent on a residential publishing training course and asked to sign an undertaking to stay at IOP Publishing for at least two years. Although Richard refused to sign, as he did not want to commit himself, he has remained with the journal since then. The following year, the Assistant Editor of Journal of Physics C: Solid State Physics, Malcolm Haines, walked out without notice in order to work on his family vineyard in France, and Richard stepped into the breach. In those days, external editors had a much more hands-on role in IOP Publishing and he had to travel to Harwell to be interviewed by Alan Lidiard, the Honorary Editor of Journal of Physics C: Solid State Physics, before being given the job of Assistant Editor permanently. I am told that in those days the job consisted mainly of editing and proofreading and peer review. There was no journal development work. At some point in the early 1980s, production and peer review were split into separate departments and Richard then headed a group of journals consisting of Journal of Physics C: Solid State Physics, Journal of Physics D: Applied Physics and Journal of Physics F: Metal Physics, Semiconductor Science and Technology, Superconductor Science and Technology, Plasma Physics and Controlled Fusion, and later Nanotechnology and Modelling and Simulation

  13. Immunoreactivity of specific epitopes of PrPSc is enhanced by pretreatment in a hydrated autoclave.

    Science.gov (United States)

    Yokoyama, T; Momotani, E; Kimura, K; Yuasa, N

    1996-01-01

    An abnormal protein (PrPSc) accumulates in animals affected with scrapie. Immunoblotting procedures have been used widely to detect PrPSc. Blotted membranes were subjected to pretreatment in a hydrated autoclave, and the subsequent immunoreactivity of PrPSc was examined. The immunoreactivity of PrPSc to antisera against the synthetic peptides of the mouse PrP amino acid sequences 199 to 208 and 213 to 226 was enhanced by the pretreatment. However, the reactivity to antisera of peptide sequences 100 to 115 and 165 to 174 was not affected. The antibody-binding ability of the specific epitopes which are located close to the C-terminal end of PrP27-30 the proteinase-resistant portion of PrPSc, was enhanced by pretreatment in a hydrated autoclave. This pretreatment increased the sensitivity of PrPSc, and it would be useful for diagnosis of scrapie. PMID:8807215

  14. Ionic strength and transition metals control PrPSc protease resistance and conversion-inducing activity.

    Science.gov (United States)

    Nishina, Koren; Jenks, Samantha; Supattapone, Surachai

    2004-09-24

    The essential component of infectious prions is a misfolded protein termed PrPSc, which is produced by conformational change of a normal host protein, PrPC. It is currently unknown whether PrPSc molecules exist in a unique conformation or whether they are able to undergo additional conformational changes. Under commonly used experimental conditions, PrPSc molecules are characteristically protease-resistant and capable of inducing the conversion of PrPC molecules into new PrPSc molecules. We describe the effects of ionic strength, copper, and zinc on the conformation-dependent protease resistance and conversion-inducing activity of PrPSc molecules in scrapie-infected hamster brains. In the absence of divalent cations, PrPSc molecules were > 20-fold more sensitive to proteinase K digestion in low ionic strength buffers than in high ionic strength buffers. Addition of micromolar concentrations of copper or zinc ions restored the protease resistance of PrPSc molecules under conditions of low ionic strength. These transition metals also controlled the conformation of purified truncated PrP-(27-30) molecules at low ionic strength, confirming that the N-terminal octapeptide repeat region of PrPSc is not required for binding to copper or zinc ions. The protease-sensitive and protease-resistant conformations of PrPSc were reversibly interchangeable, and only the protease-resistant conformation of PrPSc induced by high ionic strength was able to induce the formation of new protease-resistant PrP (PrPres) molecules in vitro. These findings show that PrPSc molecules are structurally interconvertible and that only a subset of PrPSc conformations are able to induce the conversion of other PrP molecules. Copyright 2004 American Society for Biochemistry and Molecular Biology, Inc.

  15. Positive and normative modeling for Palmer amaranth control and herbicide resistance management.

    Science.gov (United States)

    Frisvold, George B; Bagavathiannan, Muthukumar V; Norsworthy, Jason K

    2017-06-01

    Dynamic optimization models are normative; they solve for what growers 'ought to do' to maximize some objective, such as long-run profits. While valuable for research, such models are difficult to solve computationally, limiting their applicability to grower resistance management education. While discussing properties of normative models in general, this study presents results of a specific positive model of herbicide resistance management, applied to Palmer amaranth control on a representative cotton farm. This positive model compares a proactive resistance management strategy to a reactive strategy with lower short-run costs, but greater risk of herbicide resistance developing. The proactive strategy can pay for itself within 1-4 years, with a yield advantage of 4% or less if the yield advantage begins within 1-2 years of adoption. Whether the proactive strategy is preferable is sensitive to resistance onset and yield losses, but less sensitive to cotton prices or baseline yields. Industry rebates to encourage residual herbicide use (to delay resistance to post-emergence treatments) may be too small to alter grower behavior or they may be paid to growers who would have used residuals anyway. Rebates change grower behavior over a relatively narrow range of model parameters. The size of rebates needed to induce a grower to adopt the proactive strategy declines significantly if growers extend their planning horizon from 1 year to 3-4 years. Whether proactive resistance management is more profitable than a reactive strategy is more sensitive to biological parameters than economic ones. Simulation results suggest growers with longer time horizons (perhaps younger ones) would be more responsive to rebate programs. More empirical work is needed to determine how much rebates increase residual use above what would occur without them. © 2017 Society of Chemical Industry. © 2017 Society of Chemical Industry.

  16. PrPSc in Salivary Glands of Scrapie-Affected Sheep▿

    OpenAIRE

    Vascellari, Marta; Nonno, Romolo; Mutinelli, Franco; Bigolaro, Michela; Di Bari, Michele Angelo; Melchiotti, Erica; Marcon, Stefano; D'Agostino, Claudia; Vaccari, Gabriele; Conte, Michela; De Grossi, Luigi; Rosone, Francesca; Giordani, Francesco; Agrimi, Umberto

    2007-01-01

    The salivary glands of scrapie-affected sheep and healthy controls were investigated for the presence of the pathological prion protein (PrPSc). PrPSc was detected in major (parotid and mandibular) and minor (buccal, labial, and palatine) salivary glands of naturally and experimentally infected sheep. Using Western blotting, the PrPSc concentration in glands was estimated to be 0.02 to 0.005% of that in brain. Immunohistochemistry revealed intracellular depositions of PrPSc in ductal and acin...

  17. Alternative fates of newly formed PrPSc upon prion conversion on the plasma membrane

    OpenAIRE

    Goold, Rob; McKinnon, Chris; Rabbanian, Samira; Collinge, John; Schiavo, Giampietro; Tabrizi, Sarah J.

    2013-01-01

    Prion diseases are fatal neurodegenerative diseases characterised by the accumulation of misfolded prion protein (PrPSc) in the brain. They are caused by the templated misfolding of normal cellular protein, PrPC, by PrPSc. We have recently generated a unique cell system in which epitope-tagged PrPC competent to produce bona fide PrPSc is expressed in neuroblastoma cells. Using this system we demonstrated that PrPSc forms on the cell surface within minutes of prion exposure. Here, we describe ...

  18. Biology of PrPsc accumulation in two natural scrapie-infected sheep flocks.

    Science.gov (United States)

    Caplazi, Patrick; O'Rourke, Katherine; Wolf, Cynthia; Shaw, Daniel; Baszler, Timothy V

    2004-11-01

    Sheep scrapie is a prion disease that requires interaction of exogenous prions with host prion protein (PrP) supporting prion formation. Disease is associated with deposition of a host-generated conformational variant of PrP, PrPsc, in a variety of tissues, including brain, resulting in fatal spongiform encephalopathy. Efficiency of PrPsc formation is determined by polymorphisms in the PrP-coding sequence. This article adds to previous data of natural sheep scrapie, concentrating on the effect of host genotype and age on PrPsc accumulation patterns during preclinical and clinical disease. Two entire scrapie-infected, predominantly Suffolk-cross, sheep flocks euthanized for regulatory purposes were genotyped and analyzed for PrPsc deposition in various tissues using single- and dual-label immunohistochemistry. Scrapie, as defined by PrPsc deposition, occurred in 13/80 sheep. Preclinical disease was evident in nearly 70% of infected sheep, ranging in age from 14 months to 7 years. PrPsc accumulated systemically in the nervous tissue, various lymphoid tissues, both alimentary tract related and non-alimentary tract related, and the placenta. Clinical neurological illness was always associated with spongiform encephalopathy and PrPsc deposition in the brain. Only 6 of 9 sheep with preclinical scrapie had PrPsc deposition in the brain but widespread PrPsc deposition in peripheral lymphoid tissue, supporting previous data showing peripheral PrPsc accumulation preceding deposition in the brain. PrPsc colocalized with a marker for follicular dendritic cells throughout the lymphoid system. PrPsc also accumulated in the peripheral nervous system, particularly the nervous supply of the gastrointestinal tract. Abundant PrPsc was evident in trophoblast cells of placentomes but not in the endometrium, myometrium, or associated nervous plexus. PrPsc deposits were not observed in the mammary parenchyma or bone marrow. Scrapie susceptibility was defined genetically by PrP codon 171

  19. Distribution of Peripheral PrPSc in Sheep with Naturally Acquired Scrapie

    Science.gov (United States)

    Garza, María Carmen; Monzón, Marta; Marín, Belén; Badiola, Juan José; Monleón, Eva

    2014-01-01

    Accumulation of prion protein (PrPSc) in the central nervous system is the hallmark of transmissible spongiform encephalopathies. However, in some of these diseases such as scrapie or chronic wasting disease, the PrPSc can also accumulate in other tissues, particularly in the lymphoreticular system. In recent years, PrPSc in organs other than nervous and lymphoid have been described, suggesting that distribution of this protein in affected individuals may be much larger than previously thought. In the present study, 11 non-nervous/non-lymphoid organs from 16 naturally scrapie infected sheep in advanced stages of the disease were examined for the presence of PrPSc. Fourteen infected sheep were of the ARQ/ARQ PRNP genotype and 2 of the VRQ/VRQ, where the letters A, R, Q, and V represent the codes for amino-acids alanine, arginine, glutamine and valine, respectively. Adrenal gland, pancreas, heart, skin, urinary bladder and mammary gland were positive for PrPSc by immunohistochemistry and IDEXX HerdChek scrapie/BSE Antigen EIA Test in at least one animal. Lung, liver, kidney and skeletal muscle exhibited PrPSc deposits by immunohistochemistry only. To our knowledge, this is the first report regarding the presence of PrPSc in the heart, pancreas and urinary bladder in naturally acquired scrapie infections. In some other organs examined, in which PrPSc had been previously detected, PrPSc immunolabeling was observed to be associated with new structures within those organs. The results of the present study illustrate a wide dissemination of PrPSc in both ARQ/ARQ and VRQ/VRQ infected sheep, even when the involvement of the lymphoreticular system is scarce or absent, thus highlighting the role of the peripheral nervous system in the spread of PrPSc. PMID:24828439

  20. Rapid detoxification via glutathione S-transferase (GST) conjugation confers a high level of atrazine resistance in Palmer amaranth (Amaranthus palmeri).

    Science.gov (United States)

    Nakka, Sridevi; Godar, Amar S; Thompson, Curtis R; Peterson, Dallas E; Jugulam, Mithila

    2017-11-01

    Palmer amaranth (Amaranthus palmeri) is an economically troublesome, aggressive and damaging weed that has evolved resistance to six herbicide modes of action including photosystem II (PS II) inhibitors such as atrazine. The objective of this study was to investigate the mechanism and inheritance of atrazine resistance in Palmer amaranth. A population of Palmer amaranth from Kansas (KSR) had a high level (160 - 198-fold more; SE ±21 - 26) of resistance to atrazine compared to the two known susceptible populations MSS and KSS, from Mississippi and Kansas, respectively. Sequence analysis of the chloroplastic psbA gene did not reveal any known mutations conferring resistance to PS II inhibitors, including the most common Ser264Gly substitution for triazine resistance. However, the KSR plants rapidly conjugated atrazine at least 24 times faster than MSS via glutathione S-transferase (GST) activity. Furthermore, genetic analyses of progeny generated from reciprocal crosses of KSR and MSS demonstrate that atrazine resistance in Palmer amaranth is a nuclear trait. Although triazine resistance in Palmer amaranth was reported more than 20 years ago in the USA, this is the first report elucidating the underlying mechanism of resistance to atrazine. The non-target-site based metabolic resistance to atrazine mediated by GST activity may predispose the Palmer amaranth populations to have resistance to other herbicide families, and the nuclear inheritance of the trait in this dioecious species further exacerbates the propensity for its rapid spread. © 2017 Society of Chemical Industry. © 2017 Society of Chemical Industry.

  1. Sex differences in the Kimchi-Palmer task revisited: Global reaction times, but not number of global choices differ between adult men and women.

    Science.gov (United States)

    Scheuringer, Andrea; Pletzer, Belinda

    2016-10-15

    Research, directly assessing sex-dependent differences in global versus local processing is sparse, but predominantly suggesting that men show a stronger global processing bias than women. Utilizing the Kimchi-Palmer task however, sex differences in the number of global choices can only be found in children, but not in adults. In the current study 52 men and 46 women completed a computerized version of the Kimchi Palmer task, in order to investigate whether sex-differences in global-local processing in the Kimchi-Palmer task are reflected in choice reaction times rather than choices per se. While no sex differences were found in the number of global choices, we found that especially women are faster in making local choices than men, while men are faster in making global choices than women. We did not find support for the assumption that this sex difference was modulated by menstrual cycle phase of women, since the difference between reaction times to global and local choices was consistent across the menstrual cycle of women. Accordingly there was no relationship between progesterone and global-local processing in the Kimchi-Palmer task. However, like in studies utilizing the Navon task, testosterone was positively related to the number of global choices in both men and women. To our knowledge, this is the first study including reaction times as outcome measure in a Kimchi Palmer paradigm and also the first study demonstrating sex differences in the Kimchi Palmer task in adults. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

  2. Hyperspectral Technologies for Assessing Seed Germination and Trifloxysulfuron-methyl Response in Amaranthus palmeri (Palmer Amaranth).

    Science.gov (United States)

    Matzrafi, Maor; Herrmann, Ittai; Nansen, Christian; Kliper, Tom; Zait, Yotam; Ignat, Timea; Siso, Dana; Rubin, Baruch; Karnieli, Arnon; Eizenberg, Hanan

    2017-01-01

    Weed infestations in agricultural systems constitute a serious challenge to agricultural sustainability and food security worldwide. Amaranthus palmeri S. Watson (Palmer amaranth) is one of the most noxious weeds causing significant yield reductions in various crops. The ability to estimate seed viability and herbicide susceptibility is a key factor in the development of a long-term management strategy, particularly since the misuse of herbicides is driving the evolution of herbicide response in various weed species. The limitations of most herbicide response studies are that they are conducted retrospectively and that they use in vitro destructive methods. Development of a non-destructive method for the prediction of herbicide response could vastly improve the efficacy of herbicide applications and potentially delay the evolution of herbicide resistance. Here, we propose a toolbox based on hyperspectral technologies and data analyses aimed to predict A. palmeri seed germination and response to the herbicide trifloxysulfuron-methyl. Complementary measurement of leaf physiological parameters, namely, photosynthetic rate, stomatal conductence and photosystem II efficiency, was performed to support the spectral analysis. Plant response to the herbicide was compared to image analysis estimates using mean gray value and area fraction variables. Hyperspectral reflectance profiles were used to determine seed germination and to classify herbicide response through examination of plant leaves. Using hyperspectral data, we have successfully distinguished between germinating and non-germinating seeds, hyperspectral classification of seeds showed accuracy of 81.9 and 76.4%, respectively. Sensitive and resistant plants were identified with high degrees of accuracy (88.5 and 90.9%, respectively) from leaf hyperspectral reflectance profiles acquired prior to herbicide application. A correlation between leaf physiological parameters and herbicide response (sensitivity

  3. Gunfight at the NOT OK Corral: Reply to “High Noon for Microfinance” by Duvendack and Palmer-Jones (Uncut version)

    Science.gov (United States)

    Pitt, Mark M.

    2013-01-01

    The paper “High Noon for Microfinance Impact Evaluations” by Duvendack and Palmer-Jones replicates the papers of Chemin (2008) and Pitt and Khandker (1998) that estimate the impact of microfinance in Bangladesh. My paper replicates the Duvendack and Palmer-Jones replication and finds so many serious errors in their code and misrepresentations of the methods described in their paper that I conclude that their results are spurious and provide no evidence about the validity of either the papers of Chemin or Pitt and Khandker or on the effectiveness of microfinance. PMID:24833807

  4. File list: Oth.PSC.50.Smad1.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.50.Smad1.AllCell mm9 TFs and others Smad1 Pluripotent stem cell SRX1082039,...SRX1082040,SRX1082043,SRX1082042 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.50.Smad1.AllCell.bed ...

  5. File list: Oth.PSC.10.Smad2.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.10.Smad2.AllCell mm9 TFs and others Smad2 Pluripotent stem cell SRX390391,S...RX390396,SRX026469,SRX026468,SRX026467 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.10.Smad2.AllCell.bed ...

  6. File list: Oth.PSC.10.Smad3.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.10.Smad3.AllCell mm9 TFs and others Smad3 Pluripotent stem cell SRX026257,S...RX477547,SRX026254,SRX026255,SRX026256 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.10.Smad3.AllCell.bed ...

  7. File list: Oth.PSC.05.Epitope_tags.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.05.Epitope_tags.AllCell mm9 TFs and others Epitope tags Pluripotent stem ce...821,ERX320410,SRX266822,SRX352996,ERX320411 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.05.Epitope_tags.AllCell.bed ...

  8. File list: Oth.PSC.50.Epitope_tags.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.50.Epitope_tags.AllCell mm9 TFs and others Epitope tags Pluripotent stem ce...708,ERX320411,SRX647912,SRX204802,SRX352995 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.50.Epitope_tags.AllCell.bed ...

  9. File list: Oth.PSC.10.Epitope_tags.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.10.Epitope_tags.AllCell hg19 TFs and others Epitope tags Pluripotent stem c...ell SRX555489 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Oth.PSC.10.Epitope_tags.AllCell.bed ...

  10. File list: Oth.PSC.20.Epitope_tags.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.20.Epitope_tags.AllCell hg19 TFs and others Epitope tags Pluripotent stem c...ell SRX555489 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Oth.PSC.20.Epitope_tags.AllCell.bed ...

  11. File list: Oth.PSC.10.Usp16.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.10.Usp16.AllCell mm9 TFs and others Usp16 Pluripotent stem cell SRX385945,S...RX385946,SRX385953,SRX385952 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.10.Usp16.AllCell.bed ...

  12. File list: Oth.PSC.50.Msl2.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.50.Msl2.AllCell mm9 TFs and others Msl2 Pluripotent stem cell SRX368311,SRX...368310,SRX368302,SRX368303 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.50.Msl2.AllCell.bed ...

  13. File list: Oth.PSC.10.Msl1.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.10.Msl1.AllCell mm9 TFs and others Msl1 Pluripotent stem cell SRX368300,SRX...368301,SRX404386 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.10.Msl1.AllCell.bed ...

  14. File list: Oth.PSC.05.Msl1.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.05.Msl1.AllCell mm9 TFs and others Msl1 Pluripotent stem cell SRX368301,SRX...368300,SRX404386 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.05.Msl1.AllCell.bed ...

  15. File list: NoD.PSC.10.NA.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available NoD.PSC.10.NA.AllCell mm9 No description NA Pluripotent stem cell ERX238065,SRX3671...X390868,ERX390871,DRX000343,SRX336239,ERX022755 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/NoD.PSC.10.NA.AllCell.bed ...

  16. File list: Oth.PSC.50.Usp16.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available RX385952,SRX385953,SRX385946 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.50.Usp16.AllCell.bed ... ...Oth.PSC.50.Usp16.AllCell mm9 TFs and others Usp16 Pluripotent stem cell SRX385945,S

  17. File list: Oth.PSC.20.NANOG.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.20.NANOG.AllCell hg19 TFs and others NANOG Pluripotent stem cell SRX266862,...3,SRX1303985,SRX011618,SRX011617,SRX702038 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Oth.PSC.20.NANOG.AllCell.bed ...

  18. File list: Oth.PSC.10.NANOG.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.10.NANOG.AllCell hg19 TFs and others NANOG Pluripotent stem cell SRX266862,...7,SRX011618,SRX702037,SRX1303985,SRX702038 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Oth.PSC.10.NANOG.AllCell.bed ...

  19. File list: Oth.PSC.50.NANOG.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.50.NANOG.AllCell hg19 TFs and others NANOG Pluripotent stem cell SRX266862,...85,SRX702042,SRX011618,SRX011617,SRX702038 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Oth.PSC.50.NANOG.AllCell.bed ...

  20. File list: Oth.PSC.05.NANOG.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.05.NANOG.AllCell hg19 TFs and others NANOG Pluripotent stem cell SRX702036,...40,SRX702037,SRX011618,SRX011617,SRX702038 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Oth.PSC.05.NANOG.AllCell.bed ...

  1. File list: Oth.PSC.50.Smarca4.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.50.Smarca4.AllCell mm9 TFs and others Smarca4 Pluripotent stem cell SRX1300...3820,SRX823825,SRX823833,SRX823835 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.50.Smarca4.AllCell.bed ...

  2. File list: Oth.PSC.05.Biotin.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.05.Biotin.AllCell mm9 TFs and others Biotin Pluripotent stem cell SRX218273...67,SRX115147,SRX312228,SRX984569,SRX984573,SRX984572,SRX984568,SRX218274,SRX172568 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.05.Biotin.AllCell.bed ...

  3. File list: Oth.PSC.50.Biotin.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.50.Biotin.AllCell mm9 TFs and others Biotin Pluripotent stem cell SRX477548...68,SRX172568,SRX218274,SRX327702,SRX213792,SRX213794,SRX172567,SRX312228,SRX327701 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.50.Biotin.AllCell.bed ...

  4. File list: NoD.PSC.05.NA.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available NoD.PSC.05.NA.AllCell mm9 No description NA Pluripotent stem cell ERX232294,ERX1494...X472664,SRX472658,SRX472655,ERX390867,SRX336239 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/NoD.PSC.05.NA.AllCell.bed ...

  5. File list: Pol.PSC.20.RNA_polymerase_II.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.PSC.20.RNA_polymerase_II.AllCell hg19 RNA polymerase RNA polymerase II Pluripot...670820,SRX702057,SRX702061 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Pol.PSC.20.RNA_polymerase_II.AllCell.bed ...

  6. File list: Pol.PSC.05.RNA_polymerase_III.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.PSC.05.RNA_polymerase_III.AllCell hg19 RNA polymerase RNA polymerase III Plurip...otent stem cell http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Pol.PSC.05.RNA_polymerase_III.AllCell.bed ...

  7. File list: InP.PSC.10.Input_control.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.PSC.10.Input_control.AllCell hg19 Input control Input control Pluripotent stem ...RX342849,ERX342851 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/InP.PSC.10.Input_control.AllCell.bed ...

  8. File list: Oth.PSC.05.SALL4.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.05.SALL4.AllCell hg19 TFs and others SALL4 Pluripotent stem cell SRX702073,...SRX702074 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Oth.PSC.05.SALL4.AllCell.bed ...

  9. File list: Oth.PSC.20.SALL4.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.20.SALL4.AllCell hg19 TFs and others SALL4 Pluripotent stem cell SRX702074,...SRX702073 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Oth.PSC.20.SALL4.AllCell.bed ...

  10. File list: Oth.PSC.10.SALL4.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.10.SALL4.AllCell hg19 TFs and others SALL4 Pluripotent stem cell SRX702073,...SRX702074 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Oth.PSC.10.SALL4.AllCell.bed ...

  11. File list: Oth.PSC.50.SALL4.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.50.SALL4.AllCell hg19 TFs and others SALL4 Pluripotent stem cell SRX702074,...SRX702073 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Oth.PSC.50.SALL4.AllCell.bed ...

  12. File list: Oth.PSC.05.Etv2.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.05.Etv2.AllCell mm9 TFs and others Etv2 Pluripotent stem cell SRX652259,SRX...652260 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.05.Etv2.AllCell.bed ...

  13. File list: Oth.PSC.10.Etv2.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.10.Etv2.AllCell mm9 TFs and others Etv2 Pluripotent stem cell SRX652259,SRX...652260 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.10.Etv2.AllCell.bed ...

  14. File list: Oth.PSC.20.Etv2.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.20.Etv2.AllCell mm9 TFs and others Etv2 Pluripotent stem cell SRX652260,SRX...652259 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.20.Etv2.AllCell.bed ...

  15. File list: Pol.PSC.50.AllAg.mESCs,_differentiated [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.PSC.50.AllAg.mESCs,_differentiated mm9 RNA polymerase Pluripotent stem cell mESCs, different...iated SRX590276 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Pol.PSC.50.AllAg.mESCs,_differentiated.bed ...

  16. File list: ALL.PSC.20.AllAg.mESCs,_differentiated [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.PSC.20.AllAg.mESCs,_differentiated mm9 All antigens Pluripotent stem cell mESCs, different...barchive.biosciencedbc.jp/kyushu-u/mm9/assembled/ALL.PSC.20.AllAg.mESCs,_differentiated.bed ...

  17. File list: DNS.PSC.20.AllAg.mESCs,_differentiated [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available DNS.PSC.20.AllAg.mESCs,_differentiated mm9 DNase-seq Pluripotent stem cell mESCs, different...iated http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/DNS.PSC.20.AllAg.mESCs,_differentiated.bed ...

  18. File list: ALL.PSC.05.AllAg.mESCs,_differentiated [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.PSC.05.AllAg.mESCs,_differentiated mm9 All antigens Pluripotent stem cell mESCs, different...barchive.biosciencedbc.jp/kyushu-u/mm9/assembled/ALL.PSC.05.AllAg.mESCs,_differentiated.bed ...

  19. File list: ALL.PSC.50.AllAg.mESCs,_differentiated [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.PSC.50.AllAg.mESCs,_differentiated mm9 All antigens Pluripotent stem cell mESCs, different...barchive.biosciencedbc.jp/kyushu-u/mm9/assembled/ALL.PSC.50.AllAg.mESCs,_differentiated.bed ...

  20. File list: Pol.PSC.05.AllAg.mESCs,_differentiated [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.PSC.05.AllAg.mESCs,_differentiated mm9 RNA polymerase Pluripotent stem cell mESCs, different...iated SRX590276 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Pol.PSC.05.AllAg.mESCs,_differentiated.bed ...

  1. File list: Oth.PSC.05.AllAg.mESCs,_differentiated [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.05.AllAg.mESCs,_differentiated mm9 TFs and others Pluripotent stem cell mESCs, different...8,SRX209322,SRX065538,SRX065537,SRX523453,SRX523451 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.05.AllAg.mESCs,_differentiated.bed ...

  2. File list: Oth.PSC.10.AllAg.mESCs,_differentiated [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.10.AllAg.mESCs,_differentiated mm9 TFs and others Pluripotent stem cell mESCs, different...2,SRX065538,SRX523453,SRX754570,SRX065537,SRX523451 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.10.AllAg.mESCs,_differentiated.bed ...

  3. File list: Unc.PSC.05.AllAg.mESCs,_differentiated [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Unc.PSC.05.AllAg.mESCs,_differentiated mm9 Unclassified Pluripotent stem cell mESCs, different...iated http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Unc.PSC.05.AllAg.mESCs,_differentiated.bed ...

  4. File list: DNS.PSC.50.AllAg.mESCs,_differentiated [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available DNS.PSC.50.AllAg.mESCs,_differentiated mm9 DNase-seq Pluripotent stem cell mESCs, different...iated http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/DNS.PSC.50.AllAg.mESCs,_differentiated.bed ...

  5. File list: Pol.PSC.20.AllAg.mESCs,_differentiated [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.PSC.20.AllAg.mESCs,_differentiated mm9 RNA polymerase Pluripotent stem cell mESCs, different...iated SRX590276 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Pol.PSC.20.AllAg.mESCs,_differentiated.bed ...

  6. File list: Pol.PSC.10.AllAg.mESCs,_differentiated [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.PSC.10.AllAg.mESCs,_differentiated mm9 RNA polymerase Pluripotent stem cell mESCs, different...iated SRX590276 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Pol.PSC.10.AllAg.mESCs,_differentiated.bed ...

  7. File list: Unc.PSC.20.AllAg.mESCs,_differentiated [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Unc.PSC.20.AllAg.mESCs,_differentiated mm9 Unclassified Pluripotent stem cell mESCs, different...iated http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Unc.PSC.20.AllAg.mESCs,_differentiated.bed ...

  8. File list: ALL.PSC.10.AllAg.mESCs,_differentiated [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.PSC.10.AllAg.mESCs,_differentiated mm9 All antigens Pluripotent stem cell mESCs, different...barchive.biosciencedbc.jp/kyushu-u/mm9/assembled/ALL.PSC.10.AllAg.mESCs,_differentiated.bed ...

  9. File list: Unc.PSC.10.AllAg.mESCs,_differentiated [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Unc.PSC.10.AllAg.mESCs,_differentiated mm9 Unclassified Pluripotent stem cell mESCs, different...iated http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Unc.PSC.10.AllAg.mESCs,_differentiated.bed ...

  10. File list: Oth.PSC.20.AllAg.mESCs,_differentiated [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.20.AllAg.mESCs,_differentiated mm9 TFs and others Pluripotent stem cell mESCs, different...4,SRX754570,SRX065538,SRX523453,SRX523451,SRX065537 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.20.AllAg.mESCs,_differentiated.bed ...

  11. File list: Oth.PSC.50.AllAg.mESCs,_differentiated [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.50.AllAg.mESCs,_differentiated mm9 TFs and others Pluripotent stem cell mESCs, different...8,SRX523453,SRX523451,SRX754570,SRX882858,SRX065537 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.50.AllAg.mESCs,_differentiated.bed ...

  12. File list: Unc.PSC.50.AllAg.mESCs,_differentiated [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Unc.PSC.50.AllAg.mESCs,_differentiated mm9 Unclassified Pluripotent stem cell mESCs, different...iated http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Unc.PSC.50.AllAg.mESCs,_differentiated.bed ...

  13. File list: DNS.PSC.05.AllAg.mESCs,_differentiated [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available DNS.PSC.05.AllAg.mESCs,_differentiated mm9 DNase-seq Pluripotent stem cell mESCs, different...iated http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/DNS.PSC.05.AllAg.mESCs,_differentiated.bed ...

  14. File list: DNS.PSC.10.AllAg.mESCs,_differentiated [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available DNS.PSC.10.AllAg.mESCs,_differentiated mm9 DNase-seq Pluripotent stem cell mESCs, different...iated http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/DNS.PSC.10.AllAg.mESCs,_differentiated.bed ...

  15. File list: Oth.PSC.05.Mapk8.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.05.Mapk8.AllCell mm9 TFs and others Mapk8 Pluripotent stem cell SRX032471,S...RX032480,SRX032481,SRX032470 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.05.Mapk8.AllCell.bed ...

  16. File list: Oth.PSC.50.Mapk8.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.50.Mapk8.AllCell mm9 TFs and others Mapk8 Pluripotent stem cell SRX032481,S...RX032470,SRX032480,SRX032471 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.50.Mapk8.AllCell.bed ...

  17. File list: Oth.PSC.20.Mapk8.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.20.Mapk8.AllCell mm9 TFs and others Mapk8 Pluripotent stem cell SRX032481,S...RX032470,SRX032471,SRX032480 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.20.Mapk8.AllCell.bed ...

  18. File list: Oth.PSC.10.Mapk8.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.10.Mapk8.AllCell mm9 TFs and others Mapk8 Pluripotent stem cell SRX032471,S...RX032481,SRX032470,SRX032480 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.10.Mapk8.AllCell.bed ...

  19. File list: Oth.PSC.20.Zic3.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.20.Zic3.AllCell mm9 TFs and others Zic3 Pluripotent stem cell SRX147572,SRX...823607 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.20.Zic3.AllCell.bed ...

  20. File list: Pol.PSC.20.RNA_Polymerase_II.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.PSC.20.RNA_Polymerase_II.AllCell mm9 RNA polymerase RNA Polymerase II Pluripote...SRX213760,SRX213764 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Pol.PSC.20.RNA_Polymerase_II.AllCell.bed ...

  1. File list: Pol.PSC.50.RNA_Polymerase_II.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.PSC.50.RNA_Polymerase_II.AllCell mm9 RNA polymerase RNA Polymerase II Pluripote...SRX213760,SRX213764 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Pol.PSC.50.RNA_Polymerase_II.AllCell.bed ...

  2. File list: Pol.PSC.05.RNA_Polymerase_III.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.PSC.05.RNA_Polymerase_III.AllCell mm9 RNA polymerase RNA Polymerase III Pluripo...tent stem cell http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Pol.PSC.05.RNA_Polymerase_III.AllCell.bed ...

  3. File list: Pol.PSC.20.RNA_Polymerase_III.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.PSC.20.RNA_Polymerase_III.AllCell mm9 RNA polymerase RNA Polymerase III Pluripo...tent stem cell http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Pol.PSC.20.RNA_Polymerase_III.AllCell.bed ...

  4. Methionine Sulfoxides on PrPSc: A Prion-Specific Covalent Signature

    NARCIS (Netherlands)

    Canello, T.; Engelstein, R.; Moshel, O.; Xanthopoulos, K.; Langeveld, J.P.M.; Sklaviadis, T.; Gasset, M.; Gabizon, R.

    2008-01-01

    Prion diseases are fatal neurodegenerative disorders believed to be transmitted by PrPSc, an aberrant form of the membrane protein PrPC. In the absence of an established form-specific covalent difference, the infectious properties of PrPSc were uniquely ascribed to the self-perpetuation properties

  5. File list: Pol.PSC.50.RNA_polymerase_III.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.PSC.50.RNA_polymerase_III.AllCell hg19 RNA polymerase RNA polymerase III Plurip...otent stem cell http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Pol.PSC.50.RNA_polymerase_III.AllCell.bed ...

  6. File list: Pol.PSC.10.RNA_polymerase_III.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.PSC.10.RNA_polymerase_III.AllCell hg19 RNA polymerase RNA polymerase III Plurip...otent stem cell http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Pol.PSC.10.RNA_polymerase_III.AllCell.bed ...

  7. File list: Oth.PSC.50.Nanog.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.50.Nanog.AllCell mm9 TFs and others Nanog Pluripotent stem cell SRX213808,S...1349,SRX1141350,SRX1141351,SRX651982,SRX213820 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.50.Nanog.AllCell.bed ...

  8. File list: Oth.PSC.20.Nanog.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.20.Nanog.AllCell mm9 TFs and others Nanog Pluripotent stem cell SRX213808,S...1351,SRX1141349,SRX1141350,SRX651982,SRX213820 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.20.Nanog.AllCell.bed ...

  9. File list: Oth.PSC.05.Nanog.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.05.Nanog.AllCell mm9 TFs and others Nanog Pluripotent stem cell SRX248286,S...3864,SRX1141351,SRX1141350,SRX651982,SRX213820 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.05.Nanog.AllCell.bed ...

  10. File list: Oth.PSC.50.Suz12.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.50.Suz12.AllCell mm9 TFs and others Suz12 Pluripotent stem cell SRX121227,S...03869,SRX381493,SRX482882,SRX482883,SRX003868 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.50.Suz12.AllCell.bed ...

  11. File list: Oth.PSC.10.Suz12.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.10.Suz12.AllCell mm9 TFs and others Suz12 Pluripotent stem cell SRX554625,S...26282,SRX978383,SRX003849,SRX482883,SRX003868 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.10.Suz12.AllCell.bed ...

  12. File list: Oth.PSC.20.Suz12.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.20.Suz12.AllCell mm9 TFs and others Suz12 Pluripotent stem cell SRX015831,S...03869,SRX236481,SRX482882,SRX482883,SRX003868 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.20.Suz12.AllCell.bed ...

  13. File list: Oth.PSC.05.Suz12.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.05.Suz12.AllCell mm9 TFs and others Suz12 Pluripotent stem cell SRX172570,S...78385,SRX026282,SRX978386,SRX003849,SRX003868 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.05.Suz12.AllCell.bed ...

  14. File list: Oth.PSC.20.T.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.20.T.AllCell mm9 TFs and others T Pluripotent stem cell SRX470210,SRX470249...,SRX470250 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.20.T.AllCell.bed ...

  15. File list: Oth.PSC.05.T.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.05.T.AllCell mm9 TFs and others T Pluripotent stem cell SRX470210,SRX470249...,SRX470250 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.05.T.AllCell.bed ...

  16. File list: Oth.PSC.10.Smc3.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.10.Smc3.AllCell mm9 TFs and others Smc3 Pluripotent stem cell SRX022690,SRX...022691 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.10.Smc3.AllCell.bed ...

  17. File list: Oth.PSC.10.Zic3.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.10.Zic3.AllCell mm9 TFs and others Zic3 Pluripotent stem cell SRX147572,SRX...823607 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.10.Zic3.AllCell.bed ...

  18. File list: Oth.PSC.20.Smc3.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.20.Smc3.AllCell mm9 TFs and others Smc3 Pluripotent stem cell SRX022690,SRX...022691 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.20.Smc3.AllCell.bed ...

  19. File list: Oth.PSC.10.TEAD4.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.10.TEAD4.AllCell hg19 TFs and others TEAD4 Pluripotent stem cell SRX190301,...SRX378124,SRX378125 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Oth.PSC.10.TEAD4.AllCell.bed ...

  20. File list: Oth.PSC.20.Ezh2.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.20.Ezh2.AllCell mm9 TFs and others Ezh2 Pluripotent stem cell SRX330667,SRX...,SRX482887,SRX328596 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.20.Ezh2.AllCell.bed ...

  1. File list: Oth.PSC.50.Crotonyl_lysine.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.50.Crotonyl_lysine.AllCell mm9 TFs and others Crotonyl lysine Pluripotent s...tem cell http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.50.Crotonyl_lysine.AllCell.bed ...

  2. File list: His.PSC.50.Pan_lysine_crotonylation.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available His.PSC.50.Pan_lysine_crotonylation.AllCell hg19 Histone Pan lysine crotonylation P...luripotent stem cell http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/His.PSC.50.Pan_lysine_crotonylation.AllCell.bed ...

  3. File list: Oth.PSC.10.T.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.10.T.AllCell hg19 TFs and others T Pluripotent stem cell SRX684519,SRX68451...8,SRX684516,SRX684517,SRX702125,SRX702123 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Oth.PSC.10.T.AllCell.bed ...

  4. File list: His.PSC.05.AllAg.iPS_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available His.PSC.05.AllAg.iPS_cells hg19 Histone Pluripotent stem cell iPS cells SRX317576,S...077,SRX317607 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/His.PSC.05.AllAg.iPS_cells.bed ...

  5. File list: NoD.PSC.20.AllAg.STAP_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available NoD.PSC.20.AllAg.STAP_cells mm9 No description Pluripotent stem cell STAP cells SRX...472660,SRX472654,SRX472663,SRX472661,SRX472656,SRX472665,SRX472662,SRX472655,SRX472664 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/NoD.PSC.20.AllAg.STAP_cells.bed ...

  6. File list: His.PSC.50.AllAg.iPS_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available His.PSC.50.AllAg.iPS_cells mm9 Histone Pluripotent stem cell iPS cells SRX977417,SR...RX127376,SRX146530,SRX146522,SRX146547,SRX333561,SRX035985,SRX1090869 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/His.PSC.50.AllAg.iPS_cells.bed ...

  7. File list: ALL.PSC.50.AllAg.iPS_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.PSC.50.AllAg.iPS_cells hg19 All antigens Pluripotent stem cell iPS cells SRX088...16,SRX189400,SRX189399 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/ALL.PSC.50.AllAg.iPS_cells.bed ...

  8. File list: His.PSC.10.AllAg.iPS_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available His.PSC.10.AllAg.iPS_cells hg19 Histone Pluripotent stem cell iPS cells SRX110016,S...315,SRX381309 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/His.PSC.10.AllAg.iPS_cells.bed ...

  9. File list: ALL.PSC.20.AllAg.iPS_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.PSC.20.AllAg.iPS_cells hg19 All antigens Pluripotent stem cell iPS cells SRX088...27,SRX189400,SRX189399 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/ALL.PSC.20.AllAg.iPS_cells.bed ...

  10. File list: NoD.PSC.05.AllAg.STAP_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available NoD.PSC.05.AllAg.STAP_cells mm9 No description Pluripotent stem cell STAP cells SRX...472660,SRX472663,SRX472654,SRX472665,SRX472656,SRX472662,SRX472661,SRX472664,SRX472655 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/NoD.PSC.05.AllAg.STAP_cells.bed ...

  11. File list: Oth.PSC.05.Tcf12.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.05.Tcf12.AllCell mm9 TFs and others Tcf12 Pluripotent stem cell SRX390394,S...RX390392,SRX390397,SRX390399 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.05.Tcf12.AllCell.bed ...

  12. File list: Oth.PSC.20.SMAD4.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.20.SMAD4.AllCell hg19 TFs and others SMAD4 Pluripotent stem cell SRX064483,...SRX064492,SRX702097,SRX702092,SRX702095,SRX702098,SRX702096 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Oth.PSC.20.SMAD4.AllCell.bed ...

  13. File list: Oth.PSC.50.SMAD1.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.50.SMAD1.AllCell hg19 TFs and others SMAD1 Pluripotent stem cell SRX702075,...4,SRX702077 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Oth.PSC.50.SMAD1.AllCell.bed ...

  14. File list: Oth.PSC.05.SMAD4.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.05.SMAD4.AllCell hg19 TFs and others SMAD4 Pluripotent stem cell SRX064483,...SRX064492,SRX702092,SRX702095,SRX702098,SRX702096,SRX702097,SRX702094 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Oth.PSC.05.SMAD4.AllCell.bed ...

  15. File list: Oth.PSC.50.Hoxb4.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.50.Hoxb4.AllCell mm9 TFs and others Hoxb4 Pluripotent stem cell SRX109459,S...RX109455,SRX109457 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.50.Hoxb4.AllCell.bed ...

  16. File list: Oth.PSC.05.Hoxb4.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.05.Hoxb4.AllCell mm9 TFs and others Hoxb4 Pluripotent stem cell SRX109459,S...RX109457,SRX109455 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.05.Hoxb4.AllCell.bed ...

  17. File list: Oth.PSC.20.Kdm2a.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.20.Kdm2a.AllCell mm9 TFs and others Kdm2a Pluripotent stem cell SRX017108,S...RX186544 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.20.Kdm2a.AllCell.bed ...

  18. File list: Oth.PSC.50.Kdm2a.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.50.Kdm2a.AllCell mm9 TFs and others Kdm2a Pluripotent stem cell SRX186544,S...RX017108 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.50.Kdm2a.AllCell.bed ...

  19. File list: Oth.PSC.10.Kdm2a.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.10.Kdm2a.AllCell mm9 TFs and others Kdm2a Pluripotent stem cell SRX017108,S...RX186544 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.10.Kdm2a.AllCell.bed ...

  20. File list: Oth.PSC.05.Kdm2a.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.05.Kdm2a.AllCell mm9 TFs and others Kdm2a Pluripotent stem cell SRX017108,S...RX186544 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.05.Kdm2a.AllCell.bed ...

  1. File list: Oth.PSC.05.Usp16.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available RX385952,SRX385946,SRX385953 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.05.Usp16.AllCell.bed ... ...Oth.PSC.05.Usp16.AllCell mm9 TFs and others Usp16 Pluripotent stem cell SRX385945,S

  2. File list: Oth.PSC.20.Usp16.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available RX385952,SRX385953,SRX385946 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.20.Usp16.AllCell.bed ... ...Oth.PSC.20.Usp16.AllCell mm9 TFs and others Usp16 Pluripotent stem cell SRX385945,S

  3. File list: InP.PSC.05.Input_control.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.PSC.05.Input_control.AllCell hg19 Input control Input control Pluripotent stem ...RX342849,ERX342851 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/InP.PSC.05.Input_control.AllCell.bed ...

  4. File list: Oth.PSC.05.Arid3a.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.05.Arid3a.AllCell mm9 TFs and others Arid3a Pluripotent stem cell SRX520224...,SRX520225 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.05.Arid3a.AllCell.bed ...

  5. File list: Oth.PSC.10.Arid3a.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.10.Arid3a.AllCell mm9 TFs and others Arid3a Pluripotent stem cell SRX520224...,SRX520225 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.10.Arid3a.AllCell.bed ...

  6. File list: Oth.PSC.20.Arid3a.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.20.Arid3a.AllCell mm9 TFs and others Arid3a Pluripotent stem cell SRX520224...,SRX520225 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.20.Arid3a.AllCell.bed ...

  7. File list: Oth.PSC.50.Smad3.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.50.Smad3.AllCell mm9 TFs and others Smad3 Pluripotent stem cell SRX026257,S...RX026255,SRX026256,SRX026254,SRX477547 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.50.Smad3.AllCell.bed ...

  8. File list: Oth.PSC.20.Ncapd3.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.20.Ncapd3.AllCell mm9 TFs and others Ncapd3 Pluripotent stem cell SRX104386...,SRX104387 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.20.Ncapd3.AllCell.bed ...

  9. File list: Oth.PSC.10.Smarca4.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.10.Smarca4.AllCell mm9 TFs and others Smarca4 Pluripotent stem cell SRX1901...3830,SRX823825,SRX823820,SRX823835 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.10.Smarca4.AllCell.bed ...

  10. File list: Oth.PSC.20.Smarca4.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.20.Smarca4.AllCell mm9 TFs and others Smarca4 Pluripotent stem cell SRX1300...3820,SRX823825,SRX823833,SRX823835 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.20.Smarca4.AllCell.bed ...

  11. File list: Oth.PSC.05.PAX6.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.05.PAX6.AllCell hg19 TFs and others PAX6 Pluripotent stem cell SRX702055,SR...X702056 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Oth.PSC.05.PAX6.AllCell.bed ...

  12. File list: Oth.PSC.10.PAX6.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.10.PAX6.AllCell hg19 TFs and others PAX6 Pluripotent stem cell SRX702055,SR...X702056 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Oth.PSC.10.PAX6.AllCell.bed ...

  13. File list: His.PSC.50.AllAg.iPS_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available His.PSC.50.AllAg.iPS_cells hg19 Histone Pluripotent stem cell iPS cells SRX110015,S...079,SRX317585 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/His.PSC.50.AllAg.iPS_cells.bed ...

  14. File list: Pol.PSC.20.AllAg.iPS_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.PSC.20.AllAg.iPS_cells mm9 RNA polymerase Pluripotent stem cell iPS cells SRX97...7435,SRX977434,SRX027462 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Pol.PSC.20.AllAg.iPS_cells.bed ...

  15. File list: ALL.PSC.05.AllAg.iPS_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.PSC.05.AllAg.iPS_cells hg19 All antigens Pluripotent stem cell iPS cells SRX753...00,SRX189399,SRX317607 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/ALL.PSC.05.AllAg.iPS_cells.bed ...

  16. File list: Pol.PSC.10.AllAg.iPS_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.PSC.10.AllAg.iPS_cells mm9 RNA polymerase Pluripotent stem cell iPS cells SRX97...7435,SRX977434,SRX027462 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Pol.PSC.10.AllAg.iPS_cells.bed ...

  17. File list: ALL.PSC.05.AllAg.iPS_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.PSC.05.AllAg.iPS_cells mm9 All antigens Pluripotent stem cell iPS cells SRX9774...30,SRX146524,SRX146522,SRX146547 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/ALL.PSC.05.AllAg.iPS_cells.bed ...

  18. File list: Oth.PSC.50.AllAg.iPS_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.50.AllAg.iPS_cells mm9 TFs and others Pluripotent stem cell iPS cells SRX97...RX146524 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.50.AllAg.iPS_cells.bed ...

  19. File list: Pol.PSC.50.AllAg.iPS_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.PSC.50.AllAg.iPS_cells mm9 RNA polymerase Pluripotent stem cell iPS cells SRX97...7435,SRX977434,SRX027462 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Pol.PSC.50.AllAg.iPS_cells.bed ...

  20. File list: DNS.PSC.20.AllAg.iPS_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available DNS.PSC.20.AllAg.iPS_cells hg19 DNase-seq Pluripotent stem cell iPS cells SRX040379...,SRX040378,SRX135563,SRX040377,SRX040376,SRX189427,SRX189400,SRX189399 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/DNS.PSC.20.AllAg.iPS_cells.bed ...

  1. File list: DNS.PSC.10.AllAg.iPS_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available DNS.PSC.10.AllAg.iPS_cells hg19 DNase-seq Pluripotent stem cell iPS cells SRX040379...,SRX040378,SRX040377,SRX040376,SRX135563,SRX189427,SRX189400,SRX189399 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/DNS.PSC.10.AllAg.iPS_cells.bed ...

  2. File list: Pol.PSC.05.AllAg.iPS_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.PSC.05.AllAg.iPS_cells mm9 RNA polymerase Pluripotent stem cell iPS cells SRX97...7435,SRX027462,SRX977434 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Pol.PSC.05.AllAg.iPS_cells.bed ...

  3. File list: ALL.PSC.10.AllAg.iPS_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.PSC.10.AllAg.iPS_cells hg19 All antigens Pluripotent stem cell iPS cells SRX753...09,SRX189400,SRX189399 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/ALL.PSC.10.AllAg.iPS_cells.bed ...

  4. File list: His.PSC.10.AllAg.iPS_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available His.PSC.10.AllAg.iPS_cells mm9 Histone Pluripotent stem cell iPS cells SRX977417,SR...RX127372,SRX1090869,SRX127376,SRX035977,SRX146530,SRX146547,SRX146522 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/His.PSC.10.AllAg.iPS_cells.bed ...

  5. File list: Oth.PSC.20.AllAg.iPS_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.20.AllAg.iPS_cells mm9 TFs and others Pluripotent stem cell iPS cells SRX97...RX146524 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.20.AllAg.iPS_cells.bed ...

  6. File list: DNS.PSC.05.AllAg.iPS_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available DNS.PSC.05.AllAg.iPS_cells hg19 DNase-seq Pluripotent stem cell iPS cells SRX040379...,SRX040378,SRX040377,SRX040376,SRX135563,SRX189427,SRX189400,SRX189399 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/DNS.PSC.05.AllAg.iPS_cells.bed ...

  7. File list: His.PSC.20.AllAg.iPS_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available His.PSC.20.AllAg.iPS_cells mm9 Histone Pluripotent stem cell iPS cells SRX127389,SR...RX127372,SRX127373,SRX1090869,SRX127376,SRX146530,SRX146522,SRX146547 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/His.PSC.20.AllAg.iPS_cells.bed ...

  8. File list: Oth.PSC.10.AllAg.iPS_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.10.AllAg.iPS_cells mm9 TFs and others Pluripotent stem cell iPS cells SRX65...RX146524 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.10.AllAg.iPS_cells.bed ...

  9. File list: His.PSC.05.AllAg.iPS_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available His.PSC.05.AllAg.iPS_cells mm9 Histone Pluripotent stem cell iPS cells SRX977417,SR...RX127374,SRX127373,SRX1090869,SRX333561,SRX146530,SRX146522,SRX146547 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/His.PSC.05.AllAg.iPS_cells.bed ...

  10. File list: ALL.PSC.10.AllAg.iPS_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.PSC.10.AllAg.iPS_cells mm9 All antigens Pluripotent stem cell iPS cells SRX9774...30,SRX146524,SRX146547,SRX146522 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/ALL.PSC.10.AllAg.iPS_cells.bed ...

  11. File list: Oth.PSC.05.AllAg.Embryoid_Bodies [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.05.AllAg.Embryoid_Bodies mm9 TFs and others Pluripotent stem cell Embryoid Bodie...s SRX248287,SRX109459,SRX212082,SRX248285,SRX109457,SRX109455,SRX026524,SRX385952,SRX385953 http://dbarchive.bioscie...ncedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.05.AllAg.Embryoid_Bodies.bed ...

  12. File list: Unc.PSC.50.AllAg.Embryoid_Bodies [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Unc.PSC.50.AllAg.Embryoid_Bodies mm9 Unclassified Pluripotent stem cell Embryoid Bodie...353849,SRX353851,SRX353852,SRX353850 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Unc.PSC.50.AllAg.Embryoid_Bodies.bed ...

  13. File list: NoD.PSC.10.AllAg.Embryoid_Bodies [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available NoD.PSC.10.AllAg.Embryoid_Bodies mm9 No description Pluripotent stem cell Embryoid Bodie...s http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/NoD.PSC.10.AllAg.Embryoid_Bodies.bed ...

  14. File list: Unc.PSC.20.Unclassified.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Unc.PSC.20.Unclassified.AllCell hg19 Unclassified Unclassified Pluripotent stem cel...84499,SRX501950,SRX1099969,SRX1099982,SRX1099961,SRX1099958,SRX1099970,SRX1099949,SRX1099977,SRX1099965 http://dbarchive.bioscie...ncedbc.jp/kyushu-u/hg19/assembled/Unc.PSC.20.Unclassified.AllCell.bed ...

  15. File list: Pol.PSC.50.AllAg.Embryoid_Bodies [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.PSC.50.AllAg.Embryoid_Bodies mm9 RNA polymerase Pluripotent stem cell Embryoid Bodie...s http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Pol.PSC.50.AllAg.Embryoid_Bodies.bed ...

  16. File list: His.PSC.20.AllAg.Embryoid_Bodies [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available His.PSC.20.AllAg.Embryoid_Bodies mm9 Histone Pluripotent stem cell Embryoid Bodies ...SRX385955,SRX385956,SRX385958,SRX385957 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/His.PSC.20.AllAg.Embryoid_Bodies.bed ...

  17. File list: InP.PSC.50.AllAg.Embryoid_Bodies [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.PSC.50.AllAg.Embryoid_Bodies mm9 Input control Pluripotent stem cell Embryoid Bodie...s SRX109460,SRX109458,SRX212083,SRX109456,SRX385954,SRX026526 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/InP.PSC.50.AllAg.Embryoid_Bodies.bed ...

  18. File list: DNS.PSC.20.AllAg.Embryoid_Bodies [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available DNS.PSC.20.AllAg.Embryoid_Bodies mm9 DNase-seq Pluripotent stem cell Embryoid Bodie...s http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/DNS.PSC.20.AllAg.Embryoid_Bodies.bed ...

  19. File list: Pol.PSC.20.AllAg.Embryoid_Bodies [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.PSC.20.AllAg.Embryoid_Bodies mm9 RNA polymerase Pluripotent stem cell Embryoid Bodie...s http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Pol.PSC.20.AllAg.Embryoid_Bodies.bed ...

  20. File list: Pol.PSC.05.RNA_polymerase_II.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.PSC.05.RNA_polymerase_II.AllCell hg19 RNA polymerase RNA polymerase II Pluripot...833412,SRX149642,SRX702059 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Pol.PSC.05.RNA_polymerase_II.AllCell.bed ...

  1. File list: His.PSC.20.Pan_lysine_crotonylation.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available His.PSC.20.Pan_lysine_crotonylation.AllCell hg19 Histone Pan lysine crotonylation P...luripotent stem cell http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/His.PSC.20.Pan_lysine_crotonylation.AllCell.bed ...

  2. File list: Oth.PSC.05.Crotonyl_lysine.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.05.Crotonyl_lysine.AllCell mm9 TFs and others Crotonyl lysine Pluripotent s...tem cell http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.05.Crotonyl_lysine.AllCell.bed ...

  3. File list: His.PSC.50.Pan_lysine_crotonylation.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available His.PSC.50.Pan_lysine_crotonylation.AllCell mm9 Histone Pan lysine crotonylation Pl...uripotent stem cell http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/His.PSC.50.Pan_lysine_crotonylation.AllCell.bed ...

  4. File list: Oth.PSC.10.Crotonyl_lysine.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.10.Crotonyl_lysine.AllCell mm9 TFs and others Crotonyl lysine Pluripotent s...tem cell http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.10.Crotonyl_lysine.AllCell.bed ...

  5. File list: His.PSC.05.Pan_lysine_crotonylation.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available His.PSC.05.Pan_lysine_crotonylation.AllCell hg19 Histone Pan lysine crotonylation P...luripotent stem cell http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/His.PSC.05.Pan_lysine_crotonylation.AllCell.bed ...

  6. File list: His.PSC.20.Pan_lysine_crotonylation.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available His.PSC.20.Pan_lysine_crotonylation.AllCell mm9 Histone Pan lysine crotonylation Pl...uripotent stem cell http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/His.PSC.20.Pan_lysine_crotonylation.AllCell.bed ...

  7. File list: His.PSC.10.Pan_lysine_crotonylation.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available His.PSC.10.Pan_lysine_crotonylation.AllCell mm9 Histone Pan lysine crotonylation Pl...uripotent stem cell http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/His.PSC.10.Pan_lysine_crotonylation.AllCell.bed ...

  8. File list: Oth.PSC.10.Biotin.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.10.Biotin.AllCell mm9 TFs and others Biotin Pluripotent stem cell SRX218273...69,SRX984573,SRX115147,SRX327702,SRX984572,SRX984568,SRX115145,SRX172568,SRX218274 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.10.Biotin.AllCell.bed ...

  9. File list: Oth.PSC.20.T.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.20.T.AllCell hg19 TFs and others T Pluripotent stem cell SRX684519,SRX68451...8,SRX684516,SRX684517,SRX702125,SRX702123 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Oth.PSC.20.T.AllCell.bed ...

  10. File list: Oth.PSC.10.T.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.10.T.AllCell mm9 TFs and others T Pluripotent stem cell SRX470210,SRX470249...,SRX470250 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.10.T.AllCell.bed ...

  11. File list: Oth.PSC.50.T.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.50.T.AllCell mm9 TFs and others T Pluripotent stem cell SRX470210,SRX470249...,SRX470250 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.50.T.AllCell.bed ...

  12. File list: InP.PSC.05.Input_control.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.PSC.05.Input_control.AllCell mm9 Input control Input control Pluripotent stem c... http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/InP.PSC.05.Input_control.AllCell.bed ...

  13. File list: Oth.PSC.05.5-Methylcytosine.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.05.5-Methylcytosine.AllCell mm9 TFs and others 5-Methylcytosine Pluripotent... stem cell http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.05.5-Methylcytosine.AllCell.bed ...

  14. File list: Oth.PSC.20.5-Methylcytosine.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.20.5-Methylcytosine.AllCell mm9 TFs and others 5-Methylcytosine Pluripotent... stem cell http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.20.5-Methylcytosine.AllCell.bed ...

  15. File list: Oth.PSC.20.5-Methylcytosine.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.20.5-Methylcytosine.AllCell hg19 TFs and others 5-Methylcytosine Pluripoten...t stem cell http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Oth.PSC.20.5-Methylcytosine.AllCell.bed ...

  16. File list: Oth.PSC.10.5-Methylcytosine.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.10.5-Methylcytosine.AllCell mm9 TFs and others 5-Methylcytosine Pluripotent... stem cell http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.10.5-Methylcytosine.AllCell.bed ...

  17. File list: Oth.PSC.50.5-Methylcytosine.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.50.5-Methylcytosine.AllCell mm9 TFs and others 5-Methylcytosine Pluripotent... stem cell http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.50.5-Methylcytosine.AllCell.bed ...

  18. File list: Oth.PSC.20.Crotonyl_lysine.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.20.Crotonyl_lysine.AllCell mm9 TFs and others Crotonyl lysine Pluripotent s...tem cell http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.20.Crotonyl_lysine.AllCell.bed ...

  19. File list: Oth.PSC.10.Nipbl.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.10.Nipbl.AllCell mm9 TFs and others Nipbl Pluripotent stem cell SRX022697,S...RX022696 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.10.Nipbl.AllCell.bed ...

  20. File list: Oth.PSC.05.Nipbl.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.05.Nipbl.AllCell mm9 TFs and others Nipbl Pluripotent stem cell SRX022697,S...RX022696 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.05.Nipbl.AllCell.bed ...

  1. File list: Oth.PSC.20.Nipbl.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.20.Nipbl.AllCell mm9 TFs and others Nipbl Pluripotent stem cell SRX022697,S...RX022696 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.20.Nipbl.AllCell.bed ...

  2. File list: Oth.PSC.50.Nipbl.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.50.Nipbl.AllCell mm9 TFs and others Nipbl Pluripotent stem cell SRX022697,S...RX022696 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.50.Nipbl.AllCell.bed ...

  3. File list: Oth.PSC.05.NIPBL.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.05.NIPBL.AllCell hg19 TFs and others NIPBL Pluripotent stem cell SRX833423,...SRX833420,SRX833422,SRX833421 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Oth.PSC.05.NIPBL.AllCell.bed ...

  4. File list: Oth.PSC.50.NIPBL.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.50.NIPBL.AllCell hg19 TFs and others NIPBL Pluripotent stem cell SRX833423,...SRX833420,SRX833421,SRX833422 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Oth.PSC.50.NIPBL.AllCell.bed ...

  5. File list: Oth.PSC.20.NIPBL.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.20.NIPBL.AllCell hg19 TFs and others NIPBL Pluripotent stem cell SRX833423,...SRX833420,SRX833421,SRX833422 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Oth.PSC.20.NIPBL.AllCell.bed ...

  6. File list: Oth.PSC.10.NIPBL.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.10.NIPBL.AllCell hg19 TFs and others NIPBL Pluripotent stem cell SRX833423,...SRX833422,SRX833420,SRX833421 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Oth.PSC.10.NIPBL.AllCell.bed ...

  7. File list: Oth.PSC.05.Zic3.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.05.Zic3.AllCell mm9 TFs and others Zic3 Pluripotent stem cell SRX147572,SRX...823607 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.05.Zic3.AllCell.bed ...

  8. File list: Oth.PSC.50.Zic3.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.50.Zic3.AllCell mm9 TFs and others Zic3 Pluripotent stem cell SRX147572,SRX...823607 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.50.Zic3.AllCell.bed ...

  9. File list: Oth.PSC.20.YY1.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.20.YY1.AllCell hg19 TFs and others YY1 Pluripotent stem cell SRX100558,SRX1...57662,SRX150503 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Oth.PSC.20.YY1.AllCell.bed ...

  10. File list: Oth.PSC.20.Epitope_tags.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.20.Epitope_tags.AllCell mm9 TFs and others Epitope tags Pluripotent stem ce...822,SRX266828,SRX352996,ERX320411,SRX204802 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.20.Epitope_tags.AllCell.bed ...

  11. File list: Oth.PSC.05.Hnrnpl.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.05.Hnrnpl.AllCell mm9 TFs and others Hnrnpl Pluripotent stem cell SRX747756...,SRX747757 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.05.Hnrnpl.AllCell.bed ...

  12. File list: InP.PSC.50.Input_control.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.PSC.50.Input_control.AllCell hg19 Input control Input control Pluripotent stem ...RX199884,SRX189977 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/InP.PSC.50.Input_control.AllCell.bed ...

  13. File list: InP.PSC.20.Input_control.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.PSC.20.Input_control.AllCell hg19 Input control Input control Pluripotent stem ...RX342850,ERX342851 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/InP.PSC.20.Input_control.AllCell.bed ...

  14. File list: ALL.PSC.50.AllAg.iPS_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.PSC.50.AllAg.iPS_cells mm9 All antigens Pluripotent stem cell iPS cells SRX9773...1,SRX035985,SRX1090869 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/ALL.PSC.50.AllAg.iPS_cells.bed ...

  15. File list: ALL.PSC.20.AllAg.iPS_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.PSC.20.AllAg.iPS_cells mm9 All antigens Pluripotent stem cell iPS cells SRX9773...30,SRX146522,SRX146547 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/ALL.PSC.20.AllAg.iPS_cells.bed ...

  16. File list: His.PSC.20.AllAg.iPS_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available His.PSC.20.AllAg.iPS_cells hg19 Histone Pluripotent stem cell iPS cells SRX110015,S...315,SRX381309 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/His.PSC.20.AllAg.iPS_cells.bed ...

  17. File list: Oth.PSC.05.AllAg.iPS_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.05.AllAg.iPS_cells mm9 TFs and others Pluripotent stem cell iPS cells SRX65...RX146524 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.05.AllAg.iPS_cells.bed ...

  18. File list: DNS.PSC.50.AllAg.iPS_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available DNS.PSC.50.AllAg.iPS_cells hg19 DNase-seq Pluripotent stem cell iPS cells SRX040379...,SRX040378,SRX135563,SRX040376,SRX040377,SRX189427,SRX189400,SRX189399 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/DNS.PSC.50.AllAg.iPS_cells.bed ...

  19. File list: Oth.PSC.10.Chd4.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.10.Chd4.AllCell mm9 TFs and others Chd4 Pluripotent stem cell SRX823605,SRX...695697,SRX047143,SRX047142,SRX333575,SRX333583,SRX333563,SRX333579,SRX333571 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.10.Chd4.AllCell.bed ...

  20. File list: Oth.PSC.50.Rbpj.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.50.Rbpj.AllCell mm9 TFs and others Rbpj Pluripotent stem cell SRX297989,SRX...262848,SRX262849,SRX297990 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.50.Rbpj.AllCell.bed ...

  1. File list: Oth.PSC.05.Rbpj.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.05.Rbpj.AllCell mm9 TFs and others Rbpj Pluripotent stem cell SRX262848,SRX...297990,SRX297989,SRX262849 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.05.Rbpj.AllCell.bed ...

  2. File list: Oth.PSC.10.Rbpj.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.10.Rbpj.AllCell mm9 TFs and others Rbpj Pluripotent stem cell SRX262848,SRX...262849,SRX297990,SRX297989 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.10.Rbpj.AllCell.bed ...

  3. File list: Oth.PSC.20.Rbpj.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.20.Rbpj.AllCell mm9 TFs and others Rbpj Pluripotent stem cell SRX262849,SRX...262848,SRX297989,SRX297990 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.20.Rbpj.AllCell.bed ...

  4. File list: Oth.PSC.20.Biotin.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.20.Biotin.AllCell mm9 TFs and others Biotin Pluripotent stem cell SRX477548...44,SRX115145,SRX984568,SRX172568,SRX218274,SRX327702,SRX312228,SRX213794,SRX327701 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.20.Biotin.AllCell.bed ...

  5. Plasminogen: A cellular protein cofactor for PrPSc propagation.

    Science.gov (United States)

    Mays, Charles E; Ryou, Chongsuk

    2011-01-01

    The biochemical essence of prion replication is the molecular multiplication of the disease-associated misfolded isoform of prion protein (PrP), termed PrPSc, in a nucleic acid-free manner. PrP(Sc) is generated by the protein misfolding process facilitated by conformational conversion of the host-encoded cellular PrP to PrP(Sc). Evidence suggests that an auxiliary factor may play a role in PrP(Sc) propagation. We and others previously discovered that plasminogen interacts with PrP, while its functional role for PrPSc propagation remained undetermined. In our recent in vitro PrP conversion study, we showed that plasminogen substantially stimulates PrP(Sc) propagation in a concentration-dependent manner by accelerating the rate of PrP(Sc) generation, while depletion of plasminogen, destabilization of its structure, and interference with the PrP-plasminogen interaction hinder PrP(Sc) propagation. Further investigation in cell culture models confirmed an increase of PrP(Sc) formation by plasminogen. Although molecular basis of the observed activity for plasminogen remain to be addressed, our results demonstrate that plasminogen is the first cellular protein auxiliary factor proven to stimulate PrP(Sc) propagation.

  6. Effectiveness Evaluation on Fire Drills for Emergency and PSC Inspections on Board

    Directory of Open Access Journals (Sweden)

    Jianjun Wu

    2014-06-01

    Full Text Available The paper evaluates effectiveness of fire drills for emergency and responding to PSC inspections on board. A brief background about the PSC inspection on fire drills on board is introduced in the beginning. Then the significance of effectiveness evaluation on fire drills is presented. Next, legal ground is discussed on International Conventions, including regulation of related regional group, national maritime laws and rules and Concentrated Inspection Campaign (CIC. Furthermore, PSC New Inspection Regime (NIR for Paris MOU and Tokyo MOU are also discussed, and many deficiencies related to fire safety measures found in the PSC inspection are statistically analyzed. More importantly, the paper introduces System Engineering Theory, presents the principle and method of effectiveness evaluation, focuses on the preparation, performance and rehabilitation of fire drill and develops the Criterion of Effectiveness Evaluation. Finally, some suggestions are raised to carry out effectiveness evaluation for emergency and responding to the PSC inspection.

  7. PR3-ANCA: a promising biomarker in primary sclerosing cholangitis (PSC.

    Directory of Open Access Journals (Sweden)

    Laura M Stinton

    Full Text Available The only recognized biomarker for primary sclerosing cholangitis (PSC is atypical anti-neutrophil cytoplasmic antibodies (aANCA, which, in addition to having low sensitivity and specificity, is an indirect immunofluorescence (IIF test lacking the advantages of high throughput and objectivity. Recent reports have shown that antibodies to proteinase-3 (PR3-ANCA might add diagnostic value in inflammatory bowel disease (IBD, specifically in ulcerative colitis (UC. As PSC is associated with IBD, the objective of this study was to evaluate the frequency and clinical significance of PR3-ANCA in a large cohort of patients.A total of 244 PSC and 254 control [autoimmune hepatitis (AIH, primary biliary cirrhosis (PBC, hepatitis C viral infection (HCV, hepatitis B viral infection (HBV, and healthy controls] sera and their clinical correlations were retrospectively analyzed for PR3-ANCA determined by ELISA and a new chemiluminescence immunoassay (CIA. Testing was also performed for aANCA by IIF.When measured by CIA, PR3-ANCA was detected in 38.5% (94/244 of PSC patients compared to 10.6% (27/254 controls (p<0.0001. By ELISA, PR3-ANCA was detected in 23.4% (57/244 of PSC patients compared to 2.7% (6/254 controls (p<0.0001. PR3-ANCA in PSC patients was not associated with the presence or type of underlying IBD, and, in fact, it was more frequent in Crohn's disease (CD patients with PSC than previously reported in CD alone. PR3-ANCA in PSC measured by CIA correlated with higher liver enzymes.PR3-ANCA is detected in a significant proportion of PSC patients compared to other liver diseases including PBC and AIH. PR3-ANCA is associated with higher liver enzyme levels in PSC, and is not solely related to underlying IBD.

  8. High residue cover crops alone or with strategic tillage to manage glyphosate-resistant palmer amaranth (amaranthus palmeri) in Southeastern cotton (gossypium hirsutum)

    Science.gov (United States)

    Glyphosate-resistant (GR) Palmer amaranth (Amaranthus palmeri S. Wats) is redefining row crop weed management in the Southeast due to its widespread distribution, high competitive ability, copious seed production, and resilience to standard weed management programs. Herbicides alone are failing to p...

  9. Observed trends for CF3-containing compounds in background air at Cape Meares, Oregon, Point Barrow, Alaska, and Palmer Station, Antarctica

    NARCIS (Netherlands)

    Culbertson, J. A.; Prins, J. M.; Grimsrud, E. P.; Rasmussen, R. A.; Khalil, M. A. K.; Shearer, M. J.

    2004-01-01

    The concentrations of CF(3)-containing compounds in archived air samples collected at Cape Meares, Oregon, from 1978 to 1997, at Point Barrow, Alaska, from 1995 to 1998, and at Palmer Station, Antarctica, from 1991 to 1997, were determined by high resolution gas chromatography and high resolution

  10. Identification of the mob genes of plasmid pSC101 and characterization of a hybrid pSC101-R1162 system for conjugal mobilization.

    Science.gov (United States)

    Meyer, R

    2000-09-01

    Similarities in DNA base sequence indicate that pSC101 and R1162 encode related systems for conjugal mobilization, although these plasmids are otherwise very different. The mob region of pSC101 was cloned, and two genes that are required for transfer were identified. One gene, mobA, encodes a protein similar in amino acid sequence to the DNA processing domain of the R1162 MobA protein. The other gene, mobX, is within the same transcriptional unit as the pSC101 mobA and is located just downstream, at the same position occupied by mobB in R1162. Despite this, the MobB and MobX proteins do not appear to be closely related based on a comparison of their amino acid sequences. Complementation analysis indicated that neither of the pSC101 Mob proteins could substitute for, or be replaced by, their R1162 counterparts, nor were they active together at the R1162 origin of transfer (oriT). However, the full set of R1162 Mob proteins did recognize the pSC101 oriT. A hybrid system for mobilization, active at the R1162 oriT site, was constructed. This system consists of MobX and a chimeric protein made up of the DNA cleaving-ligating domain of the R1162 MobA protein joined to a fragment of pSC101 MobA. Previous results suggested that MobB and a region of MobA distinct from the DNA processing domain together formed a functional unit in transfer. The present results support this model because the chimeric MobA, although active on R1162 oriT, requires the pSC101 protein MobX for efficient plasmid mobilization.

  11. Engineering-derived approaches for iPSC preparation, expansion, differentiation and applications.

    Science.gov (United States)

    Li, Yang; Li, Ling; Chen, Zhi-Nan; Gao, Ge; Yao, Rui; Sun, Wei

    2017-07-31

    Remarkable achievements have been made since induced pluripotent stem cells (iPSCs) were first introduced in 2006. Compared with non-pluripotent stem cells, iPSC research faces several additional complexities, such as the choice of extracellular matrix proteins, growth and differentiation factors, as well as technical challenges related to self-renewal and directed differentiation. Overcoming these challenges requires the integration of knowledge and technologies from multiple fields including cell biology, biomaterial science, engineering, physics and medicine. Here, engineering-derived iPSC approaches are reviewed according to three aspects of iPSC studies: preparation, expansion, differentiation and applications. Engineering strategies, such as 3D systems establishment, cell-matrix mechanics and the regulation of biophysical and biochemical cues, together with engineering techniques, such as 3D scaffolds, cell microspheres and bioreactors, have been applied to iPSC studies and have generated insightful results and even mini-organs such as retinas, livers and intestines. Specific results are given to demonstrate how these approaches impact iPSC behavior, and related mechanisms are discussed. In addition, cell printing technologies are presented as an advanced engineering-derived approach since they have been applied in both iPSC studies and the construction of diverse tissues and organs. Further development and possible innovations of cell printing technologies are presented in terms of creating complex and functional iPSC-derived living tissues and organs.

  12. Neonatal Transplantation Confers Maturation of PSC-Derived Cardiomyocytes Conducive to Modeling Cardiomyopathy

    Directory of Open Access Journals (Sweden)

    Gun-Sik Cho

    2017-01-01

    Full Text Available Pluripotent stem cells (PSCs offer unprecedented opportunities for disease modeling and personalized medicine. However, PSC-derived cells exhibit fetal-like characteristics and remain immature in a dish. This has emerged as a major obstacle for their application for late-onset diseases. We previously showed that there is a neonatal arrest of long-term cultured PSC-derived cardiomyocytes (PSC-CMs. Here, we demonstrate that PSC-CMs mature into adult CMs when transplanted into neonatal hearts. PSC-CMs became similar to adult CMs in morphology, structure, and function within a month of transplantation into rats. The similarity was further supported by single-cell RNA-sequencing analysis. Moreover, this in vivo maturation allowed patient-derived PSC-CMs to reveal the disease phenotype of arrhythmogenic right ventricular cardiomyopathy, which manifests predominantly in adults. This study lays a foundation for understanding human CM maturation and pathogenesis and can be instrumental in PSC-based modeling of adult heart diseases.

  13. Human iPSC-MSC-Derived Xenografts Modulate Immune Responses by Inhibiting the Cleavage of Caspases.

    Science.gov (United States)

    Li, Cheng-Lin; Leng, Yun; Zhao, Bin; Gao, Chang; Du, Fei-Fei; Jin, Ning; Lian, Qi-Zhou; Xu, Shuang-Yue; Yan, Guo-Liang; Xia, Jun-Jie; Zhuang, Guo-Hong; Fu, Qing-Ling; Qi, Zhong-Quan

    2017-07-01

    Mesenchymal stem cells (MSCs) negatively modulate immune properties. Induced pluripotent stem cells (iPSCs)-derived MSCs are alternative source of MSCs. However, the effects of iPSC-MSCs on T cells phenotypes in vivo remain unclear. We established an iPSC-MSC-transplanted host versus graft reaction mouse model using subcapsular kidney injection. Th1, Th2, regulatory T cells (Treg), and Th17 phenotypes and their cytokines were investigated in vivo and in vitro. The role of caspases and the soluble factors involved in the effects of MSCs were examined. We found that iPSC-MSC grafts led to more cell survival and less infiltration of inflammatory cells in mice. iPSC-MSC transplantation inhibited T cell proliferation, decreased Th1 and Th2 phenotypes and cytokines, upregulated Th17 and Treg subsets. Moreover, iPSC-MSCs inhibited the cleavage of caspases 3 and 8 and inhibition of caspases downregulated Th1, Th2 responses and upregulated Th17, Treg responses. Soluble factors were determined using protein array and TGF-β1/2/3, IL-10, and MCP-1 were found to be highly expressed in iPSC-MSCs. The administration of the soluble factors decreased Th1/2 response, upregulated Treg response and inhibited the cleavage of caspases. Our results demonstrate that iPSC-MSCs regulate T cell responses as a result of a combined action of the above soluble factors secreted by iPSC-MSCs. These factors suppress T cell responses by inhibiting the cleavage of caspases. These data provide a novel immunomodulatory mechanism for the underlying iPSC-MSC-based immunomodulatory effects on T cell responses. Stem Cells 2017;35:1719-1732. © 2017 The Authors STEM CELLS published by Wiley Periodicals, Inc. on behalf of AlphaMed Press.

  14. Development of Embedded EM Sensors for Estimating Tensile Forces of PSC Girder Bridges.

    Science.gov (United States)

    Kim, Junkyeong; Kim, Ju-Won; Lee, Chaggil; Park, Seunghee

    2017-08-30

    The tensile force of pre-stressed concrete (PSC) girders is the most important factor for managing the stability of PSC bridges. The tensile force is induced using pre-stressing (PS) tendons of a PSC girder. Because the PS tendons are located inside of the PSC girder, the tensile force cannot be measured after construction using conventional NDT (non-destructive testing) methods. To monitor the induced tensile force of a PSC girder, an embedded EM (elasto-magnetic) sensor was proposed in this study. The PS tendons are made of carbon steel, a ferromagnetic material. The magnetic properties of the ferromagnetic specimen are changed according to the induced magnetic field, temperature, and induced stress. Thus, the tensile force of PS tendons can be estimated by measuring their magnetic properties. The EM sensor can measure the magnetic properties of ferromagnetic materials in the form of a B (magnetic density)-H (magnetic force) loop. To measure the B-H loop of a PS tendon in a PSC girder, the EM sensor should be embedded into the PSC girder. The proposed embedded EM sensor can be embedded into a PSC girder as a sheath joint by designing screw threads to connect with the sheath. To confirm the proposed embedded EM sensors, the experimental study was performed using a down-scaled PSC girder model. Two specimens were constructed with embedded EM sensors, and three sensors were installed in each specimen. The embedded EM sensor could measure the B-H loop of PS tendons even if it was located inside concrete, and the area of the B-H loop was proportionally decreased according to the increase in tensile force. According to the results, the proposed method can be used to estimate the tensile force of unrevealed PS tendons.

  15. Survey of Abdominal Access and Associated Morbidity for Robot-Assisted Radical Prostatectomy: Does Palmer's Point Warrant Further Awareness and Study?

    Science.gov (United States)

    Johnston, William K; Linsell, Susan; Miller, David; Ghani, Khurshid R

    2017-03-01

    Laparoscopic access for robot-assisted radical prostatectomy (RARP) is often initiated in the periumbilical location. Palmer's point, located in the left upper quadrant, has been reported as an alternative access site for pelvic laparoscopy to reduce morbidity, but not widely reported among urologists. To better understand surgeons' preferences for access and its associated morbidity during RARP, we surveyed surgeons from two urologic organizations. An anonymous online questionnaire (SurveyMonkey) consisting of 17 questions that assessed training, experience, and preferences for RARP was emailed in December 2014 and collected until February 2015 to members performing RARP of the Endourology Society (ES) and the Michigan Urological Society Improvement Collaborative (MUSIC). Surgeons were also asked to share their personal experience with a vascular, death or life-threatening event (DOLTE), or bowel injury during RARP. Questionnaires were answered by 111 surgeons in total (ES, n = 71 and MUSIC, n = 40) with an estimated total response rate of 5.5%. In total, 77% reported prior experience with the Veress needle method before exposure to RARP and 71% of respondents primarily use the Veress needle for RARP, with 73% reporting access primarily at the periumbilical location. A personal experience with a vascular or a bowel injury during Veress needle insertion was reported in 18% and 9% of surgeons, respectively; furthermore, 26% of respondents were personally aware of at least 1 DOLTE among colleagues (5% reported 3 or more). The majority (56%) of respondents were unaware of Palmer's point, while among the minority aware of Palmer's point, only 33% reported ever using this location. In this survey, surgeons most commonly access the abdomen at the periumbilical location with a Veress needle for RARP with the majority not aware or utilizing Palmer's point. Nearly one in five surgeons reported a personal experience with a vascular injury during access for RARP

  16. Analysis of prion strains by PrPSc profiling in sporadic Creutzfeldt-Jakob disease.

    Science.gov (United States)

    Schoch, Gaby; Seeger, Harald; Bogousslavsky, Julien; Tolnay, Markus; Janzer, Robert Charles; Aguzzi, Adriano; Glatzel, Markus

    2006-02-01

    Prion diseases are a group of invariably fatal neurodegenerative disorders affecting humans and a wide range of mammals. An essential part of the infectious agent, termed the prion, is composed of an abnormal isoform (PrPSc) of a host-encoded normal cellular protein (PrPC). The conversion of PrPC to PrPSc is thought to play a crucial role in the development of prion diseases and leads to PrPSc deposition, mainly in the central nervous system. Sporadic Creutzfeldt-Jakob disease (sCJD), the most common form of human prion disease, presents with a marked clinical heterogeneity. This diversity is accompanied by a molecular signature which can be defined by histological, biochemical, and genetic means. The molecular classification of sCJD is an important tool to aid in the understanding of underlying disease mechanisms and the development of therapy protocols. Comparability of classifications is hampered by disparity of applied methods and inter-observer variability. To overcome these difficulties, we developed a new quantification protocol for PrPSc by using internal standards on each Western blot, which allows for generation and direct comparison of individual PrPSc profiles. By studying PrPSc profiles and PrPSc type expression within nine defined central nervous system areas of 50 patients with sCJD, we were able to show distinct PrPSc distribution patterns in diverse subtypes of sCJD. Furthermore, we were able to demonstrate the co-existence of more than one PrPSc type in individuals with sCJD in about 20% of all patients and in more than 50% of patients heterozygous for a polymorphism on codon 129 of the gene encoding the prion protein (PRNP). PrPSc profiling represents a valuable tool for the molecular classification of human prion diseases and has important implications for their diagnosis by brain biopsy. Our results show that the co-existence of more than one PrPSc type might be influenced by genetic and brain region-specific determinants. These findings

  17. Deciphering the naïve state of porcine iPSC

    DEFF Research Database (Denmark)

    Freude, Karla Kristine; Secher, Jan Ole Bertelsen; Mashayekhi-Nezamabadi, Kaveh

    PSCs derived from other mammalian species, this is not without some caveats. Firstly, all existing piPSC-like cells are afflicted by insufficient activation of endogenous pluripotency genes. Secondly and associated with this, lack of silencing of exogenous pluripotency genes is a general drawback: in contrast......, human and murine episomal reprogramming approaches lead to integration of such transgenes. Thirdly, current culturing conditions fail to support the maintenance of either porcine embryonic stem cells (pESC) or piPSC. Lastly, piPSC are unable to reproducibly contribute to chimeric embryos as demonstrated...

  18. Thoracoscopic sympathectomy ganglia ablation in the management of palmer hyperhidrosis: a decade experience in a single institution.

    Science.gov (United States)

    Kravarusic, Dragan; Freud, Enrique

    2012-01-01

    Hyperhidrosis can cause significant professional and social handicaps. Surgery is the preferred treatment modality for hyperhidrosis. There has been evolution in the surgical management of hyperhidrosis. This study evaluated the place of minimally invasive surgical approach and its long-term outcome in the management of hyperhidrosis. A 10-year prospective study of all children and adolescents who underwent thorascopic sympathectomy at the Schneider Children's Hospital of Israel. Data were validated for the procedure and analysed for outcome of procedure. There were 148 patients, 66 were males and 82 were females, with a median age of 13.8 SD ± 4.0 years. Two hundred and ninety-six thoracopic sympathectomies were performed with no conversion to open procedure. The mean operation time was 18 min. Ninety-five per cent of the patients were discharged the next day with a mean hospital stay of 1.2 days. Postoperative complications included segmental atelectasis in seven (4.72%) patients, pneumothorax in two (1.35%) and transient unilateral Horner's syndrome in one (0.67%). Seventy-one (38.8%) experienced some form of compensatory hyperhidrosis. Complete relief of palmer hyperdidrosis was achieved in all patients (mean follow-up = 5.03 ± 1.76 years). The outcome was very satisfactory in 91 (61.5%) and satisfactory in 48 (32.4%). Only nine (6.1%) were not satisfied with the outcome. Thorascopic sympathectomy provides effective and satisfactory cure for palmer hyperhidrosis with acceptable complication rate and excellent satisfactory outcome. There is a possibility of compensatory sweating in some individuals.

  19. Fluorescent Immunoassay Development for PrPSc Detection and Antemortem Diagnosis of TSEs

    National Research Council Canada - National Science Library

    Carp, Richard I

    2005-01-01

    The overall goal of our study is to develop methods of high-sensitivity and high-specificity for the antemortem diagnosis of prion diseases by detecting PrPSc in biological fluids using fluorescent immunoassay...

  20. Assessment of Strain-Specific PrPSc Elongation Rates Revealed a Transformation of PrPSc Properties during Protein Misfolding Cyclic Amplification

    Science.gov (United States)

    Gonzalez-Montalban, Nuria; Baskakov, Ilia V.

    2012-01-01

    Prion replication is believed to consist of two components, a growth or elongation of infectious isoform of the prion protein (PrPSc) particles and their fragmentation, a process that provides new replication centers. The current study introduced an experimental approach that employs Protein Misfolding Cyclic Amplification with beads (PMCAb) and relies on a series of kinetic experiments for assessing elongation rates of PrPSc particles. Four prion strains including two strains with short incubation times to disease (263K and Hyper) and two strains with very long incubation times (SSLOW and LOTSS) were tested. The elongation rate of brain-derived PrPSc was found to be strain-specific. Strains with short incubation times had higher rates than strains with long incubation times. Surprisingly, the strain-specific elongation rates increased substantially for all four strains after they were subjected to six rounds of serial PMCAb. In parallel to an increase in elongation rates, the percentages of diglycosylated PrP glycoforms increased in PMCAb-derived PrPSc comparing to those of brain-derived PrPSc. These results suggest that PMCAb selects the same molecular features regardless of strain initial characteristics and that convergent evolution of PrPSc properties occurred during in vitro amplification. These results are consistent with the hypothesis that each prion strain is comprised of a variety of conformers or ‘quasi-species’ and that change in the prion replication environment gives selective advantage to those conformers that replicate most effectively under specific environment. PMID:22815972

  1. Methamphetamine increases Prion Protein and induces dopamine-dependent expression of protease resistant PrPsc.

    Science.gov (United States)

    Ferrucci, M; Ryskalin, L; Biagioni, F; Gambardella, S; Busceti, C L; Falleni, A; Lazzeri, G; Fornai, F

    2017-07-01

    The cellular prion protein (PrPc) is physiologically expressed within selective brain areas of mammals. Alterations in the secondary structure of this protein lead to scrapie-like prion protein (PrPsc), which precipitates in the cell. PrPsc has been detected in infectious, inherited or sporadic neurodegenerative disorders. Prion protein metabolism is dependent on autophagy and ubiquitin proteasome. Despite not being fully elucidated, the physiological role of prion protein relates to chaperones which rescue cells under stressful conditions.Methamphetamine (METH) is a widely abused drug which produces oxidative stress in various brain areas causing mitochondrial alterations and protein misfolding. These effects produce a compensatory increase of chaperones while clogging cell clearing pathways. In the present study, we explored whether METH administration modifies the amount of PrPc. Since high levels of PrPc when the clearing systems are clogged may lead to its misfolding into PrPsc, we further tested whether METH exposure triggers the appearance of PrPsc. We analysed the effects of METH and dopamine administration in PC12 and striatal cells by using SDS-PAGE Coomassie blue, immune- histochemistry and immune-gold electron microscopy. To analyze whether METH administration produces PrPsc aggregates we used antibodies directed against PrP following exposure to proteinase K or sarkosyl which digest folded PrPc but misfolded PrPsc. We fond that METH triggers PrPsc aggregates in DA-containing cells while METH is not effective in primary striatal neurons which do not produce DA. In the latter cells exogenous DA is needed to trigger PrPsc accumulation similarly to what happens in DA containing cells under the effects of METH. The present findings, while fostering novel molecular mechanisms involving prion proteins, indicate that, cell pathology similar to prion disorders can be mimicked via a DA-dependent mechanism by a drug of abuse.

  2. Human iPSC-Derived GABA Ergic Precursor Cell Therapy for Chronic Epilepsy

    Science.gov (United States)

    2015-10-01

    AWARD NUMBER: W81XWH-14-1-0558 TITLE: Human iPSC-Derived GABA-Ergic Precursor Cell Therapy for Chronic Epilepsy PRINCIPAL INVESTIGATOR: Ashok K...AND SUBTITLE 5a. CONTRACT NUMBER Human iPSC-Derived GABA-Ergic Precursor Cell Therapy for Chronic Epilepsy 5b. GRANT NUMBER W81XWH-14-1-0558 5c...exhibiting chronic temporal lobe epilepsy (TLE) would: (1) greatly diminish the frequency and intensity of spontaneous recurrent seizures (SRS, Specific

  3. Ten years of iPSC: clinical potential and advances in vitro hematopoietic differentiation.

    Science.gov (United States)

    Paes, Bárbara Cristina Martins Fernandes; Moço, Pablo Diego; Pereira, Cristiano Gonçalves; Porto, Geciane Silveira; de Sousa Russo, Elisa Maria; Reis, Luiza Cunha Junqueira; Covas, Dimas Tadeu; Picanço-Castro, Virginia

    2017-06-01

    Ten years have passed since the first publication announcing the generation of induced pluripotent stem cells (iPSCs). Issues related to ethics, immune rejection, and cell availability seemed to be solved following this breakthrough. The development of iPSC technology allows advances in in vitro cell differentiation for cell therapy purpose and other clinical applications. This review provides a perspective on the iPSC potential for cell therapies, particularly for hematological applications. We discuss the advances in in vitro hematopoietic differentiation, the possibilities to employ iPSC in hematology studies, and their potential clinical application in hematologic diseases. The generation of red blood cells and functional T cells and the genome editing technology applied to mutation correction are also covered. We highlight some of the requirements and obstacles to be overcome before translating these cells from research to the clinic, for instance, iPSC variability, genotoxicity, the differentiation process, and engraftment. Also, we evaluate the patent landscape and compile the clinical trials in the field of pluripotent stem cells. Currently, we know much more about iPSC than in 2006, but there are still challenges that must be solved. A greater understanding of molecular mechanisms underlying the generation of hematopoietic stem cells is necessary to produce suitable and transplantable hematopoietic stem progenitor cells from iPSC.

  4. Design of a Tumorigenicity Test for Induced Pluripotent Stem Cell (iPSC-Derived Cell Products

    Directory of Open Access Journals (Sweden)

    Shin Kawamata

    2015-01-01

    Full Text Available Human Pluripotent Stem Cell (PSC-derived cell therapy holds enormous promise because of the cells’ “unlimited” proliferative capacity and the potential to differentiate into any type of cell. However, these features of PSC-derived cell products are associated with concerns regarding the generation of iatrogenic teratomas or tumors from residual immature or non-terminally differentiated cells in the final cell product. This concern has become a major hurdle to the introduction of this therapy into the clinic. Tumorigenicity testing is therefore a key preclinical safety test in PSC-derived cell therapy. Tumorigenicity testing becomes particularly important when autologous human induced Pluripotent Stem Cell (iPSC-derived cell products with no immuno-barrier are considered for transplantation. There has been, however, no internationally recognized guideline for tumorigenicity testing of PSC-derived cell products for cell therapy. In this review, we outline the points to be considered in the design and execution of tumorigenicity tests, referring to the tests and laboratory work that we have conducted for an iPSC-derived retinal pigment epithelium (RPE cell product prior to its clinical use.

  5. Temperature profile and nutrients data collected using bottle casts from the POLAR DUKE and NATHANIEL B. PALMER in the Ross Sea and Southern Oceans from 08 April 1997 to 05 May 1997 (NODC Accession 0000897)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Temperature profile and nutrients data were collected using bottle casts in the Ross Sea and Southern Oceans from the POLAR DUKE and NATHANIEL B. PALMER. Data were...

  6. Physical profiles collected by the R/V Laurence M. Gould in the Southern Oceans to support the Palmer Long Term Ecological Research for the purpose of ecosystem and physical oceanography research, January 6 - February 1, 2003 (NODC Accession 0039429)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Palmer Long Term Ecological Research (PAL-LTER) Temperature and Salinity profile data collected west of the Antarctic Peninsula. These data from January/February...

  7. Physical profiles collected by the R/V Laurence M. Gould in the Southern Ocean to support the Palmer Long Term Ecological Research for the purpose of ecosystem and physical oceanography research, January 4 - January 31, 2005 (NODC Accession 0039426)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Palmer Long Term Ecological Research (PAL-LTER) Temperature and Salinity profile data collected west of the Antarctic Peninsula. These data from January 2005 are...

  8. Physical profiles collected by the R/V Laurence M. Gould in the Southern Oceans to support the Palmer Long Term Ecological Research for the purpose of ecosystem and physical oceanography research, January 7 - February 3, 2006 (NODC Accession 0039224)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Palmer Long Term Ecological Research (PAL-LTER) Temperature and Salinity profile data collected west of the Antarctic Peninsula. These data from January/February...

  9. Physical profiles collected by the R/V Laurence M. Gould in the Southern Oceans to support the Palmer Long Term Ecological Research for the purpose of ecosystem and physical oceanography research, January 7 - January 31, 2004 (NODC Accession 0039427)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Palmer Long Term Ecological Research (PAL-LTER) Temperature and Salinity profile data collected west of the Antarctic Peninsula. These data from January 2004 are...

  10. Temperature, salinity, nutrient, meteorological data from CTD, bottle casts, and other instruments in the Southern Oceans (>60 degrees South) from the NATHANIEL B. PALMER from 14 February 1994 to 31 March 1994 (NODC Accession 0000484)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CTD, bottle, meteorological, and other data were collected from the Southern Oceans (>60 degrees South) from the Nathaniel B. Palmer from 14 February 1994 to 31...

  11. Temperature, salinity, oxygen, PAR and other variables collected by the R/V Nathaniel B. Palmer on the western Antarctic shelf for the GLOBEC project, April - September 2001 (NODC Accession 0000792)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — These data and reports from the R/V Nathaniel B. Palmer were collected under the auspices of GLOBEC (Global Ocean Ecosystem Dynamics). GLOBEC was initiated by the...

  12. Temperature and salinity profile data collected by the R/V NATHANIEL B. PALMER in the Southern Oceans from 26 December 1999 to 08 February 2000 (NODC Accession 0000659)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This accession contains data from 84 high resolution CTD stations, collected 26 Dec 1999 to 8 Feb 2000 by the R/V Nathaniel B Palmer. These data support the...

  13. Physical, Chemical, and Biological CTD and Bottle data from NATHANIEL B. PALMER in Eastern Tropical South Pacific Ocean near Peru/Chile from 2013-06-24 to 2013-07-22 (NCEI Accession 0128141)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This report contains data from R/V Nathaniel B. Palmer cruise NBP 1305 to the eastern tropical south pacific oxygen deficient zone. The objective of the cruise was...

  14. Temperature, salinity, nutrients, and other data from CTD and bottle casts in the Southern Ocean (> 60 South) from the R/V NATHANIEL B. PALMER from 14 September 1994 to 12 October 1994 (NODC Accession 0000481)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This report includes the primary ocean station data collected in the Pacific sector of the Southern Ocean during cruise 9405 of the Nathaniel B. Palmer. The cruise...

  15. Temperature profile and nutrients data collected using bottle casts from the POLAR DUKE and NATHANIEL B. PALMER in the Ross Sea and Southern Oceans from 10 November 1997 to 12 December 1997 (NODC Accession 0000898)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Temperature profile and nutrients data were collected using bottle casts in the Ross Sea and Southern Oceans from the POLAR DUKE and NATHANIEL B. PALMER. Data were...

  16. Temperature profile and nutrients data collected using bottle casts from the NATHANIEL B. PALMER in the Ross Sea and Southern Oceans from 09 November 1994 to 08 December 1994 (NODC Accession 0000899)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Temperature profile and nutrients data were collected using bottle casts in the Ross Sea and Southern Oceans from the NATHANIEL B. PALMER. Data were collected from...

  17. Temperature profile and nutrients data collected using bottle casts from the POLAR DUKE AND NATHANIEL B. PALMER in the Ross Sea and Southern Oceans from 12 January 1997 to 09 February 1997 (NODC Accession 0000896)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Temperature profile and nutrients data were collected using bottle casts in the Ross Sea and Southern Oceans from the POLAR DUKE and NATHANIEL B. PALMER. Data were...

  18. Temperature profile and nutrients data collected using bottle casts from the NATHANIEL B. PALMER in the Ross Sea and Southern Oceans from 16 December 1995 to 13 January 1996 (NODC Accession 0000889)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Temperature profile and nutrients data were collected using bottle casts in the Ross Sea and Southern Oceans from the NATHANIEL B. PALMER. Data were collected from...

  19. A double-blind, randomize, placebo-control trial to evaluate the effect of Nigella sativa on palmer arsenical keratosis patients

    Directory of Open Access Journals (Sweden)

    Tahmina Bashar

    2014-03-01

    Full Text Available This study was done to examine the role of Nigella sativa in 28 patients of palmer arsenical keratosis. Patients were randomized into two groups: Group A (n-15 receive capsules of placebo and vitamin E (200 mg whereas Group B (n= 13 receive capsules of N. sativa oil (500 mg and vitamin E (200 mg orally for 8 weeks. The mean (± SD clinical scoring of palmer arsenical keratosis in Group A before and after treatment was 99.3 ± 21.5 and 62.3 ± 14.3 respectively (37% reduction. On the other hand, in N. sativa oil treated group, the mean clinical score was 119.1 ± 20.3 before treatment which was reduced to 39.2 ± 8.4 (p<0.0001 after treatment (67% reduction. There were 65% reduc-tion of total arsenic in nail of Group A and 30% in Group B. In conclusion, oral administration of N. sativa oil improves the symptom of palmer arsenical keratosis as a result of reduction of body arsenic load.

  20. Inhibition of PrPSc formation by synthetic O-sulfated glycopyranosides and their polymers.

    Science.gov (United States)

    Yamaguchi, Satoko; Nishida, Yoshihiro; Sasaki, Kenji; Kambara, Mikie; Kim, Chan-Lan; Ishiguro, Naotaka; Nagatsuka, Takehiro; Uzawa, Hirotaka; Horiuchi, Motohiro

    2006-10-20

    Sulfated glycosaminoglycans (GAGs) and sulfated glycans inhibit formation of the abnormal isoform of prion protein (PrPSc) in prion-infected cells and prolong the incubation time of scrapie-infected animals. Sulfation of GAGs is not tightly regulated and possible sites of sulfation are randomly modified, which complicates elucidation of the fundamental structures of GAGs that mediate the inhibition of PrPSc formation. To address the structure-activity relationship of GAGs in the inhibition of PrPSc formation, we screened the ability of various regioselectively O-sulfated glycopyranosides to inhibit PrPSc formation in prion-infected cells. Among the glycopyranosides and their polymers examined, monomeric 4-sulfo-N-acetyl-glucosamine (4SGN), and two glycopolymers, poly-4SGN and poly-6-sulfo-N-acetyl-glucosamine (poly-6SGN), inhibited PrPSc formation with 50% effective doses below 20 microg/ml, and their inhibitory effect became more evident with consecutive treatments. Structural comparisons suggested that a combination of an N-acetyl group at C-2 and an O-sulfate group at either O-4 or O-6 on glucopyranoside might be involved in the inhibition of PrPSc formation. Furthermore, polymeric but not monomeric 6SGN inhibited PrPSc formation, suggesting the importance of a polyvalent configuration in its effect. These results indicate that the synthetic sulfated glycosides are useful not only for the analysis of structure-activity relationship of GAGs but also for the development of therapeutics for prion diseases.

  1. PrPSc spreading patterns in the brain of sheep linked to different prion types.

    Science.gov (United States)

    Wemheuer, Wiebke M; Benestad, Sylvie L; Wrede, Arne; Wemheuer, Wilhelm E; Brenig, Bertram; Bratberg, Bjørn; Schulz-Schaeffer, Walter J

    2011-02-15

    Scrapie in sheep and goats has been known for more than 250 years and belongs nowadays to the so-called prion diseases that also include e.g. bovine spongiform encephalopathy in cattle (BSE) and Creutzfeldt-Jakob disease in humans. According to the prion hypothesis, the pathological isoform (PrPSc) of the cellular prion protein (PrPc) comprises the essential, if not exclusive, component of the transmissible agent. Currently, two types of scrapie disease are known--classical and atypical/Nor98 scrapie. In the present study we examine 24 cases of classical and 25 cases of atypical/Nor98 scrapie with the sensitive PET blot method and validate the results with conventional immunohistochemistry. The sequential detection of PrPSc aggregates in the CNS of classical scrapie sheep implies that after neuroinvasion a spread from spinal cord and obex to the cerebellum, diencephalon and frontal cortex via the rostral brainstem takes place. We categorize the spread of PrPSc into four stages: the CNS entry stage, the brainstem stage, the cruciate sulcus stage and finally the basal ganglia stage. Such a sequential development of PrPSc was not detectable upon analysis of the present atypical/Nor98 scrapie cases. PrPSc distribution in one case of atypical/Nor98 scrapie in a presumably early disease phase suggests that the spread of PrPSc aggregates starts in the di- or telencephalon. In addition to the spontaneous generation of PrPSc, an uptake of the infectious agent into the brain, that bypasses the brainstem and starts its accumulation in the thalamus, needs to be taken into consideration for atypical/Nor98 scrapie.

  2. Mountain wave PSC dynamics and microphysics from ground-based lidar measurements and meteorological modeling

    Directory of Open Access Journals (Sweden)

    J. Reichardt

    2004-01-01

    Full Text Available The day-long observation of a polar stratospheric cloud (PSC by two co-located ground-based lidars at the Swedish research facility Esrange (67.9° N, 21.1° E on 16 January 1997 is analyzed in terms of PSC dynamics and microphysics. Mesoscale modeling is utilized to simulate the meteorological setting of the lidar measurements. Microphysical properties of the PSC particles are retrieved by comparing the measured particle depolarization ratio and the PSC-averaged lidar ratio with theoretical optical data derived for different particle shapes. In the morning, nitric acid trihydrate (NAT particles and then increasingly coexisting liquid ternary aerosol (LTA were detected as outflow from a mountain wave-induced ice PSC upwind Esrange. The NAT PSC is in good agreement with simulations for irregular-shaped particles with length-to-diameter ratios between 0.75 and 1.25, maximum dimensions from 0.7 to 0.9 µm, and a number density from 8 to 12 cm-3 and the coexisting LTA droplets had diameters from 0.7 to 0.9 µm, a refractive index of 1.39 and a number density from 7 to 11 cm-3. The total amount of condensed HNO3 was in the range of 8–12 ppbv. The data provide further observational evidence that NAT forms via deposition nucleation on ice particles as a number of recently published papers suggest. By early afternoon the mountain-wave ice PSC expanded above the lidar site. Its optical data indicate a decrease in minimum particle size from 3 to 1.9 µm with time. Later on, following the weakening of the mountain wave, wave-induced LTA was observed only. Our study demonstrates that ground-based lidar measurements of PSCs can be comprehensively interpreted if combined with mesoscale meteorological data.

  3. Immunolocalisation of PrPSc in scrapie-infected N2a mouse neuroblastoma cells by light and electron microscopy.

    Science.gov (United States)

    Veith, Nathalie M; Plattner, Helmut; Stuermer, Claudia A O; Schulz-Schaeffer, Walter J; Bürkle, Alexander

    2009-01-01

    The causative agent of transmissible spongiform encephalopathies (TSE) is PrPSc, an infectious, misfolded isoform of the cellular prion protein (PrPC). The localisation and trafficking of PrPSc and sites of conversion from PrPC to PrPSc are under debate, particularly since most published work did not discriminate between PrPC and PrPSc. Here we describe the localisation of PrPC and PrPSc in a scrapie-infected neuroblastoma cell line, ScN2a, by light and electron microscopic immunolocalisation. After eliminating PrPC with proteinase K, PrPSc was detected at the plasma membrane, endocytosed via clathrin-coated pits and delivered to early endosomes. Finally, PrPSc was detected in late endosomes/lysosomes. As we detected PrPSc at the cell surface, in early endosomes and in late endosomes/lysosomes, i.e. locations where PrPC is also present, our data imply that the conversion process could take place at the plasma membrane and/or along the endocytic pathway. Finally, we observed the release of PrPC/PrPSc via exocytotic pathways, i.e. via exosomes and as an opaque electron-dense mass which may represent a mechanism of intercellular spreading of infectious prions.

  4. Appraising Loftus and Palmer (1974) post-event information versus concurrent commentary in the context of sport.

    Science.gov (United States)

    Goldschmied, Nadav; Sheptock, Mark; Kim, Kacey; Galily, Yair

    2017-11-01

    Two experiments were conducted to examine framing effects in sport. In Experiment 1, a conceptual replication [Loftus, E. F., & Palmer, J. C. (1974). Reconstruction of automobile destruction: An example of the interaction between language and memory. Journal of Verbal Learning and Verbal Behavior, 13(5), 585-589], participants watched a hockey collision, with the hit described later in a written format as a "contact", "bump", or "smash". This manipulation resulted in no differences in participants' report of how fast the players were skating, their intentions, and the outcome of the hit. In Experiment 2, participants watched the same video clip with ongoing commentary. Those who heard the announcer describing the event as "contact" estimated a higher skating speed than participants who were exposed to the "smash" commentary. Participants who were exposed to the "bump" commentary rated the repercussions of the collision as less severe than did those exposed to the other commentaries. These findings show that the perception of magnitude hierarchy may be domain specific and suggest future avenues for exploring framing effects when one is exposed to visual stimuli.

  5. Neurodevelopmental origins of bipolar disorder: iPSC models.

    Science.gov (United States)

    O'Shea, K Sue; McInnis, Melvin G

    2016-06-01

    Bipolar disorder (BP) is a chronic neuropsychiatric condition characterized by pathological fluctuations in mood from mania to depression. Adoption, twin and family studies have consistently identified a significant hereditary component to BP, yet there is no clear genetic event or consistent neuropathology. BP has been suggested to have a developmental origin, although this hypothesis has been difficult to test since there are no viable neurons or glial cells to analyze, and research has relied largely on postmortem brain, behavioral and imaging studies, or has examined proxy tissues including saliva, olfactory epithelium and blood cells. Neurodevelopmental factors, particularly pathways related to nervous system development, cell migration, extracellular matrix, H3K4 methylation, and calcium signaling have been identified in large gene expression and GWAS studies as altered in BP. Recent advances in stem cell biology, particularly the ability to reprogram adult somatic tissues to a pluripotent state, now make it possible to interrogate these pathways in viable cell models. A number of induced pluripotent stem cell (iPSC) lines from BP patient and healthy control (C) individuals have been derived in several laboratories, and their ability to form cortical neurons examined. Early studies suggest differences in activity, calcium signaling, blocks to neuronal differentiation, and changes in neuronal, and possibly glial, lineage specification. Initial observations suggest that differentiation of BP patient-derived neurons to dorsal telencephalic derivatives may be impaired, possibly due to alterations in WNT, Hedgehog or Nodal pathway signaling. These investigations strongly support a developmental contribution to BP and identify novel pathways, mechanisms and opportunities for improved treatments. Copyright © 2015 Elsevier Inc. All rights reserved.

  6. Impact of Microbes on the Pathogenesis of Primary Biliary Cirrhosis (PBC) and Primary Sclerosing Cholangitis (PSC).

    Science.gov (United States)

    Mattner, Jochen

    2016-11-09

    Primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) represent the major clinical entities of chronic cholestatic liver diseases. Both disorders are characterized by portal inflammation and slowly progress to obliterative fibrosis and eventually liver cirrhosis. Although immune-pathogenic mechanisms have been implicated in the pathogenesis of PBC and PSC, neither disorder is considered to be a classical autoimmune disease, as PSC and PBC patients do not respond to immune-suppressants. Furthermore, the decreased bile flow resulting from the immune-mediated tissue assault and the subsequent accumulation of toxic bile products in PBC and PSC not only perpetuates biliary epithelial damage, but also alters the composition of the intestinal and biliary microbiota and its mutual interactions with the host. Consistent with the close association of PSC and inflammatory bowel disease (IBD), the polyclonal hyper IgM response in PBC and (auto-)antibodies which cross-react to microbial antigens in both diseases, an expansion of individual microbes leads to shifts in the composition of the intestinal or biliary microbiota and a subsequent altered integrity of epithelial layers, promoting microbial translocation. These changes have been implicated in the pathogenesis of both devastating disorders. Thus, we will discuss here these recent findings in the context of novel and alternative therapeutic options.

  7. Impact of Microbes on the Pathogenesis of Primary Biliary Cirrhosis (PBC and Primary Sclerosing Cholangitis (PSC

    Directory of Open Access Journals (Sweden)

    Jochen Mattner

    2016-11-01

    Full Text Available Primary biliary cirrhosis (PBC and primary sclerosing cholangitis (PSC represent the major clinical entities of chronic cholestatic liver diseases. Both disorders are characterized by portal inflammation and slowly progress to obliterative fibrosis and eventually liver cirrhosis. Although immune-pathogenic mechanisms have been implicated in the pathogenesis of PBC and PSC, neither disorder is considered to be a classical autoimmune disease, as PSC and PBC patients do not respond to immune-suppressants. Furthermore, the decreased bile flow resulting from the immune-mediated tissue assault and the subsequent accumulation of toxic bile products in PBC and PSC not only perpetuates biliary epithelial damage, but also alters the composition of the intestinal and biliary microbiota and its mutual interactions with the host. Consistent with the close association of PSC and inflammatory bowel disease (IBD, the polyclonal hyper IgM response in PBC and (auto-antibodies which cross-react to microbial antigens in both diseases, an expansion of individual microbes leads to shifts in the composition of the intestinal or biliary microbiota and a subsequent altered integrity of epithelial layers, promoting microbial translocation. These changes have been implicated in the pathogenesis of both devastating disorders. Thus, we will discuss here these recent findings in the context of novel and alternative therapeutic options.

  8. An Accessible Organotypic Microvessel Model Using iPSC-Derived Endothelium.

    Science.gov (United States)

    Ingram, Patrick N; Hind, Laurel E; Jiminez-Torres, Jose A; Huttenlocher, Anna; Beebe, David J

    2018-01-01

    While organotypic approaches promise increased relevance through the inclusion of increased complexity (e.g., 3D extracellular microenvironment, structure/function relationships, presence of multiple cell types), cell source is often overlooked. Induced pluripotent stem cell (iPSC)-derived cells are potentially more physiologically relevant than cell lines, while also being less variable than primary cells, and recent advances have made them commercially available at costs similar to cell lines. Here, the use of induced pluripotent stem cell-derived endothelium for the generation of a functional microvessel model is demonstrated. High precision structural and microenvironmental control afforded by the design approach synergizes with the advantages of iPSC to produce microvessels for modeling endothelial biology in vitro. iPSC microvessels show endothelial characteristics, exhibit barrier function, secrete angiogenic and inflammatory mediators, and respond to changes in the extracellular microenvironment by altering vessel phenotype. Importantly, when deployed in the investigation of neutrophils during innate immune recruitment, the presence of the iPSC endothelial vessel facilitates neutrophil extravasation and migration toward a chemotactic source. Relevant cell sources, such as iPSC, combine with organotypic models to open the way for improved and increasingly accessible in vitro tissue, disease, and patient-specific models. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  9. Human iPSC for Therapeutic Approaches to the Nervous System: Present and Future Applications

    Directory of Open Access Journals (Sweden)

    Maria Giuseppina Cefalo

    2016-01-01

    Full Text Available Many central nervous system (CNS diseases including stroke, spinal cord injury (SCI, and brain tumors are a significant cause of worldwide morbidity/mortality and yet do not have satisfying treatments. Cell-based therapy to restore lost function or to carry new therapeutic genes is a promising new therapeutic approach, particularly after human iPSCs became available. However, efficient generation of footprint-free and xeno-free human iPSC is a prerequisite for their clinical use. In this paper, we will first summarize the current methodology to obtain footprint- and xeno-free human iPSC. We will then review the current iPSC applications in therapeutic approaches for CNS regeneration and their use as vectors to carry proapoptotic genes for brain tumors and review their applications for modelling of neurological diseases and formulating new therapeutic approaches. Available results will be summarized and compared. Finally, we will discuss current limitations precluding iPSC from being used on large scale for clinical applications and provide an overview of future areas of improvement. In conclusion, significant progress has occurred in deriving iPSC suitable for clinical use in the field of neurological diseases. Current efforts to overcome technical challenges, including reducing labour and cost, will hopefully expedite the integration of this technology in the clinical setting.

  10. Allogenic iPSC-derived RPE cell transplants induce immune response in pigs: a pilot study.

    Science.gov (United States)

    Sohn, Elliott H; Jiao, Chunhua; Kaalberg, Emily; Cranston, Cathryn; Mullins, Robert F; Stone, Edwin M; Tucker, Budd A

    2015-07-03

    Stem cell strategies focused on replacement of RPE cells for the treatment of geographic atrophy are under intense investigation. Although the eye has long been considered immune privileged, there is limited information about the immune response to transplanted cells in the subretinal space of large animals. The purpose of this study was to evaluate the survival of allogenic induced pluripotent stem cell-derived RPE cells (iPSC-RPE) delivered to the subretinal space of the pig as well as determine whether these cells induce an immune response in non-diseased eyes. GFP positive iPSC-RPE, generated from outbred domestic swine, were injected into the subretinal space of vitrectomized miniature swine. Control eyes received vehicle only. GFP positive iPSC-RPE cells were identified in the subretinal space 3 weeks after injection in 5 of 6 eyes. Accompanying GFP-negative cells positive for IgG, CD45 and macrophage markers were also identified in close proximity to the injected iPSC-RPE cells. All subretinal cells were negative for GFAP as well as cell cycle markers. We found that subretinal injection of allogenic iPSC-RPE cells into wild-type mini-pigs can induce the innate immune response. These findings suggest that immunologically matched or autologous donor cells should be considered for clinical RPE cell replacement.

  11. Fail-Safe System against Potential Tumorigenicity after Transplantation of iPSC Derivatives

    Directory of Open Access Journals (Sweden)

    Go Itakura

    2017-03-01

    Full Text Available Human induced pluripotent stem cells (iPSCs are promising in regenerative medicine. However, the risks of teratoma formation and the overgrowth of the transplanted cells continue to be major hurdles that must be overcome. Here, we examined the efficacy of the inducible caspase-9 (iCaspase9 gene as a fail-safe against undesired tumorigenic transformation of iPSC-derived somatic cells. We used a lentiviral vector to transduce iCaspase9 into two iPSC lines and assessed its efficacy in vitro and in vivo. In vitro, the iCaspase9 system induced apoptosis in approximately 95% of both iPSCs and iPSC-derived neural stem/progenitor cells (iPSC-NS/PCs. To determine in vivo function, we transplanted iPSC-NS/PCs into the injured spinal cord of NOD/SCID mice. All transplanted cells whose mass effect was hindering motor function recovery were ablated upon transduction of iCaspase9. Our results suggest that the iCaspase9 system may serve as an important countermeasure against post-transplantation adverse events in stem cell transplant therapies.

  12. Accumulation profiles of PrPSc in hemal nodes of naturally and experimentally scrapie-infected sheep

    Science.gov (United States)

    2013-01-01

    Background In classical scrapie, the disease-associated abnormal isoform (PrPSc) of normal prion protein accumulates principally in the nervous system and lymphoid tissues of small ruminants. Lymph nodes traffic leukocytes via lymphatic and blood vasculatures but hemal nodes lack lymphatic vessels and thus traffic leukocytes only via the blood. Although PrPSc accumulation profiles are well-characterized in ovine lymphoid tissues, there is limited information on such profiles in hemal nodes. Therefore, the objective of this study was to compare the follicular accumulation of PrPSc within hemal nodes and lymph nodes by prion epitope mapping and western blot studies. Results Our studies found that PrPSc accumulation in 82% of animals’ abdominal hemal nodes when PrPSc is detected in both mesenteric and retropharyngeal lymph nodes collected from preclinical and clinical, naturally and experimentally (blood transfusion) scrapie-infected sheep representing all three major scrapie-susceptible Prnp genotypes. Abdominal hemal nodes and retropharyngeal lymph nodes were then used to analyze immune cell phenotypes and PrPSc epitope mapping by immunohistochemistry and PrPSc banding patterns by western blot. Similar patterns of PrPSc accumulation were detected within the secondary follicles of hemal nodes and retropharyngeal lymph nodes, where cellular labeling was mostly associated with macrophages and follicular dendritic cells. The pattern of PrPSc accumulation within hemal nodes and retropharyngeal lymph nodes also did not differ with respect to epitope mapping with seven mAbs (N-terminus, n = 4; globular domain, n = 2; C-terminus, n = 1) in all three Prnp genotypes. Western blot analysis of hemal node and retropharyngeal lymph node homogenates revealed identical three banding patterns of proteinase K resistant PrPSc. Conclusion Despite the anatomical difference in leukocyte trafficking between lymph nodes and hemal nodes, the follicles of hemal nodes appear to

  13. Cinética de degradação de vitamina c em mangas 'palmer' minimamente processadas armazenadas em diferentes temperaturas Kinects of vitamin C degradation of 'palmer' mangoes (Mangifera indica L. stored at different temperatures

    Directory of Open Access Journals (Sweden)

    Juliana Alvarenga Alves

    2010-06-01

    Full Text Available Conduziu-se este trabalho, com o objetivo de utilizar parâmetros cinéticos para avaliar a degradação de vitamina C sobre a vida útil de mangas (Mangifera indica L. minimamente processadas e armazenadas em diferentes temperaturas. Mangas 'Palmer' foram lavadas em água corrente, sanificadas, descascadas, novamente sanificadas e fatiadas manualmente. O produto foi embalado em embalagem de polietileno com tampa e armazenado a 0ºC, 6ºC e 12ºC (85-90% UR. Para o acompanhamento da sua vida útil, a cada 2 dias foram feitas as seguintes análises: valores L* a* e b*, perda de massa, pH, firmeza, sólidos solúveis (SS, acidez titulável (AT e teor de vitamina C. As mangas minimamente processadas armazenadas à 0ºC e 6ºC apresentaram vida útil de 10 dias contra 4 dias das mangas armazenadas à 12ºC. Os dados obtidos por meio de regressão linear com os valores do logaritmo neperiano do teor de ácido ascórbico pelo tempo de armazenagem (dias mostram que a reação de degradação da vitamina C se ajusta ao modelo cinético de 1ª ordem. O Modelo de Arrhenius foi aplicado às velocidades de reação (k nas diferentes temperaturas estabelecendo energia de ativação (Ea de 34,32 kcal mol-1. A degradação de vitamina C foi mais lenta (t1/2 = 63,6dias; e k = 0,0109 dias-1 à 0ºC o que proporcionou maior retenção de seus teores (89% durante 10 dias de armazenamento. As frutas armazenadas à 12ºC apresentaram maior velocidade de degradação (k = 0,1729 dias-1 e, consequentemente, t1/2 inferior às demais temperaturas (apenas 4 dias.This work was used to evaluate the kinetic parameters for degradation of vitamin C on the shelf-life of minimally processed mangoes (Mangifera indica L. stored at different temperatures. 'Palmer' Mangos were washed in running water, sanitized, peeled, manually sliced and again sanitized. The product was packaged in polyethylene packaging with lid and stored at 0ºC, 6°C and 12 °C (85-90% RH. To monitor its

  14. Drusen in patient-derived hiPSC-RPE models of macular dystrophies.

    Science.gov (United States)

    Galloway, Chad A; Dalvi, Sonal; Hung, Sandy S C; MacDonald, Leslie A; Latchney, Lisa R; Wong, Raymond C B; Guymer, Robyn H; Mackey, David A; Williams, David S; Chung, Mina M; Gamm, David M; Pébay, Alice; Hewitt, Alex W; Singh, Ruchira

    2017-09-26

    Age-related macular degeneration (AMD) and related macular dystrophies (MDs) are a major cause of vision loss. However, the mechanisms underlying their progression remain ill-defined. This is partly due to the lack of disease models recapitulating the human pathology. Furthermore, in vivo studies have yielded limited understanding of the role of specific cell types in the eye vs. systemic influences (e.g., serum) on the disease pathology. Here, we use human induced pluripotent stem cell-retinal pigment epithelium (hiPSC-RPE) derived from patients with three dominant MDs, Sorsby's fundus dystrophy (SFD), Doyne honeycomb retinal dystrophy/malattia Leventinese (DHRD), and autosomal dominant radial drusen (ADRD), and demonstrate that dysfunction of RPE cells alone is sufficient for the initiation of sub-RPE lipoproteinaceous deposit (drusen) formation and extracellular matrix (ECM) alteration in these diseases. Consistent with clinical studies, sub-RPE basal deposits were present beneath both control (unaffected) and patient hiPSC-RPE cells. Importantly basal deposits in patient hiPSC-RPE cultures were more abundant and displayed a lipid- and protein-rich "drusen-like" composition. Furthermore, increased accumulation of COL4 was observed in ECM isolated from control vs. patient hiPSC-RPE cultures. Interestingly, RPE-specific up-regulation in the expression of several complement genes was also seen in patient hiPSC-RPE cultures of all three MDs (SFD, DHRD, and ADRD). Finally, although serum exposure was not necessary for drusen formation, COL4 accumulation in ECM, and complement pathway gene alteration, it impacted the composition of drusen-like deposits in patient hiPSC-RPE cultures. Together, the drusen model(s) of MDs described here provide fundamental insights into the unique biology of maculopathies affecting the RPE-ECM interface.

  15. File list: His.PSC.50.AllAg.mESC_derived_cardiac_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available His.PSC.50.AllAg.mESC_derived_cardiac_cells mm9 Histone Pluripotent stem cell mESC derived cardiac...917,SRX305916,SRX305901,SRX305899,SRX305900,SRX305898,SRX305897 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/His.PSC.50.AllAg.mESC_derived_cardiac_cells.bed ...

  16. File list: Unc.PSC.50.AllAg.mESC_derived_cardiac_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Unc.PSC.50.AllAg.mESC_derived_cardiac_cells mm9 Unclassified Pluripotent stem cell mESC derived cardiac... cells SRX685645,SRX685643,SRX685642,SRX685644 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Unc.PSC.50.AllAg.mESC_derived_cardiac_cells.bed ...

  17. File list: Unc.PSC.05.AllAg.mESC_derived_cardiac_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Unc.PSC.05.AllAg.mESC_derived_cardiac_cells mm9 Unclassified Pluripotent stem cell mESC derived cardiac... cells SRX685643,SRX685645,SRX685642,SRX685644 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Unc.PSC.05.AllAg.mESC_derived_cardiac_cells.bed ...

  18. File list: His.PSC.05.AllAg.mESC_derived_cardiac_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available His.PSC.05.AllAg.mESC_derived_cardiac_cells mm9 Histone Pluripotent stem cell mESC derived cardiac...907,SRX305897,SRX305899,SRX305901,SRX305927,SRX305915,SRX305928 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/His.PSC.05.AllAg.mESC_derived_cardiac_cells.bed ...

  19. File list: Oth.PSC.20.AllAg.mESC_derived_cardiac_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.20.AllAg.mESC_derived_cardiac_cells mm9 TFs and others Pluripotent stem cell mESC derived cardiac...30,SRX1437359 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.20.AllAg.mESC_derived_cardiac_cells.bed ...

  20. File list: Oth.PSC.50.AllAg.mESC_derived_cardiac_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.50.AllAg.mESC_derived_cardiac_cells mm9 TFs and others Pluripotent stem cell mESC derived cardiac...359,SRX994830 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.50.AllAg.mESC_derived_cardiac_cells.bed ...

  1. File list: NoD.PSC.50.AllAg.mESC_derived_cardiac_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available NoD.PSC.50.AllAg.mESC_derived_cardiac_cells mm9 No description Pluripotent stem cell mESC derived cardiac... cells http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/NoD.PSC.50.AllAg.mESC_derived_cardiac_cells.bed ...

  2. File list: His.PSC.20.AllAg.mESC_derived_cardiac_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available His.PSC.20.AllAg.mESC_derived_cardiac_cells mm9 Histone Pluripotent stem cell mESC derived cardiac...915,SRX305901,SRX305916,SRX305898,SRX305917,SRX305900,SRX305897 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/His.PSC.20.AllAg.mESC_derived_cardiac_cells.bed ...

  3. File list: InP.PSC.50.AllAg.mESC_derived_cardiac_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.PSC.50.AllAg.mESC_derived_cardiac_cells mm9 Input control Pluripotent stem cell mESC derived cardiac...sciencedbc.jp/kyushu-u/mm9/assembled/InP.PSC.50.AllAg.mESC_derived_cardiac_cells.bed ...

  4. File list: DNS.PSC.10.AllAg.mESC_derived_cardiac_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available DNS.PSC.10.AllAg.mESC_derived_cardiac_cells mm9 DNase-seq Pluripotent stem cell mESC derived cardiac... cells http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/DNS.PSC.10.AllAg.mESC_derived_cardiac_cells.bed ...

  5. File list: ALL.PSC.10.AllAg.mESC_derived_cardiac_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.PSC.10.AllAg.mESC_derived_cardiac_cells mm9 All antigens Pluripotent stem cell mESC derived cardiac...7359 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/ALL.PSC.10.AllAg.mESC_derived_cardiac_cells.bed ...

  6. File list: ALL.PSC.20.AllAg.mESC_derived_cardiac_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.PSC.20.AllAg.mESC_derived_cardiac_cells mm9 All antigens Pluripotent stem cell mESC derived cardiac...5897 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/ALL.PSC.20.AllAg.mESC_derived_cardiac_cells.bed ...

  7. File list: ALL.PSC.05.AllAg.mESC_derived_cardiac_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.PSC.05.AllAg.mESC_derived_cardiac_cells mm9 All antigens Pluripotent stem cell mESC derived cardiac...7360 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/ALL.PSC.05.AllAg.mESC_derived_cardiac_cells.bed ...

  8. File list: ALL.PSC.50.AllAg.mESC_derived_cardiac_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.PSC.50.AllAg.mESC_derived_cardiac_cells mm9 All antigens Pluripotent stem cell mESC derived cardiac...5897 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/ALL.PSC.50.AllAg.mESC_derived_cardiac_cells.bed ...

  9. File list: DNS.PSC.20.AllAg.mESC_derived_cardiac_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available DNS.PSC.20.AllAg.mESC_derived_cardiac_cells mm9 DNase-seq Pluripotent stem cell mESC derived cardiac... cells http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/DNS.PSC.20.AllAg.mESC_derived_cardiac_cells.bed ...

  10. File list: Unc.PSC.10.AllAg.mESC_derived_cardiac_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Unc.PSC.10.AllAg.mESC_derived_cardiac_cells mm9 Unclassified Pluripotent stem cell mESC derived cardiac... cells SRX685643,SRX685645,SRX685642,SRX685644 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Unc.PSC.10.AllAg.mESC_derived_cardiac_cells.bed ...

  11. File list: Oth.PSC.10.AllAg.mESC_derived_cardiac_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.10.AllAg.mESC_derived_cardiac_cells mm9 TFs and others Pluripotent stem cell mESC derived cardiac...30,SRX1437359 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.10.AllAg.mESC_derived_cardiac_cells.bed ...

  12. File list: InP.PSC.20.AllAg.mESC_derived_cardiac_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.PSC.20.AllAg.mESC_derived_cardiac_cells mm9 Input control Pluripotent stem cell mESC derived cardiac...sciencedbc.jp/kyushu-u/mm9/assembled/InP.PSC.20.AllAg.mESC_derived_cardiac_cells.bed ...

  13. File list: Unc.PSC.20.AllAg.mESC_derived_cardiac_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Unc.PSC.20.AllAg.mESC_derived_cardiac_cells mm9 Unclassified Pluripotent stem cell mESC derived cardiac... cells SRX685645,SRX685643,SRX685642,SRX685644 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Unc.PSC.20.AllAg.mESC_derived_cardiac_cells.bed ...

  14. File list: Pol.PSC.05.AllAg.mESC_derived_cardiac_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.PSC.05.AllAg.mESC_derived_cardiac_cells mm9 RNA polymerase Pluripotent stem cell mESC derived cardiac... cells SRX305934,SRX305933,SRX305932,SRX305935 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Pol.PSC.05.AllAg.mESC_derived_cardiac_cells.bed ...

  15. File list: DNS.PSC.05.AllAg.mESC_derived_cardiac_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available DNS.PSC.05.AllAg.mESC_derived_cardiac_cells mm9 DNase-seq Pluripotent stem cell mESC derived cardiac... cells http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/DNS.PSC.05.AllAg.mESC_derived_cardiac_cells.bed ...

  16. File list: NoD.PSC.20.AllAg.mESC_derived_cardiac_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available NoD.PSC.20.AllAg.mESC_derived_cardiac_cells mm9 No description Pluripotent stem cell mESC derived cardiac... cells http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/NoD.PSC.20.AllAg.mESC_derived_cardiac_cells.bed ...

  17. File list: InP.PSC.10.AllAg.mESC_derived_cardiac_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.PSC.10.AllAg.mESC_derived_cardiac_cells mm9 Input control Pluripotent stem cell mESC derived cardiac...sciencedbc.jp/kyushu-u/mm9/assembled/InP.PSC.10.AllAg.mESC_derived_cardiac_cells.bed ...

  18. File list: His.PSC.10.AllAg.mESC_derived_cardiac_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available His.PSC.10.AllAg.mESC_derived_cardiac_cells mm9 Histone Pluripotent stem cell mESC derived cardiac...928,SRX305927,SRX305926,SRX305915,SRX305900,SRX305916,SRX305917 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/His.PSC.10.AllAg.mESC_derived_cardiac_cells.bed ...

  19. File list: NoD.PSC.05.AllAg.mESC_derived_cardiac_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available NoD.PSC.05.AllAg.mESC_derived_cardiac_cells mm9 No description Pluripotent stem cell mESC derived cardiac... cells http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/NoD.PSC.05.AllAg.mESC_derived_cardiac_cells.bed ...

  20. File list: Pol.PSC.50.AllAg.mESC_derived_cardiac_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.PSC.50.AllAg.mESC_derived_cardiac_cells mm9 RNA polymerase Pluripotent stem cell mESC derived cardiac... cells SRX305933,SRX305932,SRX305935,SRX305934 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Pol.PSC.50.AllAg.mESC_derived_cardiac_cells.bed ...

  1. File list: DNS.PSC.50.AllAg.mESC_derived_cardiac_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available DNS.PSC.50.AllAg.mESC_derived_cardiac_cells mm9 DNase-seq Pluripotent stem cell mESC derived cardiac... cells http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/DNS.PSC.50.AllAg.mESC_derived_cardiac_cells.bed ...

  2. File list: InP.PSC.05.AllAg.mESC_derived_cardiac_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.PSC.05.AllAg.mESC_derived_cardiac_cells mm9 Input control Pluripotent stem cell mESC derived cardiac...sciencedbc.jp/kyushu-u/mm9/assembled/InP.PSC.05.AllAg.mESC_derived_cardiac_cells.bed ...

  3. File list: NoD.PSC.10.AllAg.mESC_derived_cardiac_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available NoD.PSC.10.AllAg.mESC_derived_cardiac_cells mm9 No description Pluripotent stem cell mESC derived cardiac... cells http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/NoD.PSC.10.AllAg.mESC_derived_cardiac_cells.bed ...

  4. File list: Pol.PSC.20.AllAg.mESC_derived_cardiac_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.PSC.20.AllAg.mESC_derived_cardiac_cells mm9 RNA polymerase Pluripotent stem cell mESC derived cardiac... cells SRX305933,SRX305932,SRX305935,SRX305934 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Pol.PSC.20.AllAg.mESC_derived_cardiac_cells.bed ...

  5. File list: InP.PSC.05.AllAg.hESC_derived_fibroblasts [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.PSC.05.AllAg.hESC_derived_fibroblasts hg19 Input control Pluripotent stem cell hESC derived... fibroblasts http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/InP.PSC.05.AllAg.hESC_derived_fibroblasts.bed ...

  6. File list: His.PSC.10.AllAg.mESC_derived_neural_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available His.PSC.10.AllAg.mESC_derived_neural_cells mm9 Histone Pluripotent stem cell mESC derived...tp://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/His.PSC.10.AllAg.mESC_derived_neural_cells.bed ...

  7. File list: DNS.PSC.10.AllAg.iPS_derived_fibroblasts [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available DNS.PSC.10.AllAg.iPS_derived_fibroblasts hg19 DNase-seq Pluripotent stem cell iPS derived... fibroblasts http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/DNS.PSC.10.AllAg.iPS_derived_fibroblasts.bed ...

  8. File list: His.PSC.05.AllAg.hESC_derived_fibroblasts [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available His.PSC.05.AllAg.hESC_derived_fibroblasts hg19 Histone Pluripotent stem cell hESC derived...archive.biosciencedbc.jp/kyushu-u/hg19/assembled/His.PSC.05.AllAg.hESC_derived_fibroblasts.bed ...

  9. File list: Unc.PSC.05.AllAg.hESC_derived_trophoblast_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Unc.PSC.05.AllAg.hESC_derived_trophoblast_cells hg19 Unclassified Pluripotent stem cell hESC derived... trophoblast cells SRX378285 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Unc.PSC.05.AllAg.hESC_derived_trophoblast_cells.bed ...

  10. File list: Pol.PSC.20.AllAg.hESC_derived_trophoblast_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.PSC.20.AllAg.hESC_derived_trophoblast_cells hg19 RNA polymerase Pluripotent stem cell hESC derived... trophoblast cells http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Pol.PSC.20.AllAg.hESC_derived_trophoblast_cells.bed ...

  11. File list: NoD.PSC.05.AllAg.iPS_derived_fibroblasts [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available NoD.PSC.05.AllAg.iPS_derived_fibroblasts hg19 No description Pluripotent stem cell iPS derived... fibroblasts http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/NoD.PSC.05.AllAg.iPS_derived_fibroblasts.bed ...

  12. File list: InP.PSC.10.AllAg.iPS_derived_neural_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.PSC.10.AllAg.iPS_derived_neural_cells hg19 Input control Pluripotent stem cell iPS derived... neural cells SRX702550 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/InP.PSC.10.AllAg.iPS_derived_neural_cells.bed ...

  13. File list: Pol.PSC.20.AllAg.hESC_derived_fibroblasts [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.PSC.20.AllAg.hESC_derived_fibroblasts hg19 RNA polymerase Pluripotent stem cell hESC derived... fibroblasts http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Pol.PSC.20.AllAg.hESC_derived_fibroblasts.bed ...

  14. File list: NoD.PSC.50.AllAg.hESC_derived_neural_crests [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available NoD.PSC.50.AllAg.hESC_derived_neural_crests hg19 No description Pluripotent stem cell hESC derived... neural crests http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/NoD.PSC.50.AllAg.hESC_derived_neural_crests.bed ...

  15. File list: DNS.PSC.05.AllAg.hESC_derived_neural_crests [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available DNS.PSC.05.AllAg.hESC_derived_neural_crests hg19 DNase-seq Pluripotent stem cell hESC derived... neural crests http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/DNS.PSC.05.AllAg.hESC_derived_neural_crests.bed ...

  16. File list: Unc.PSC.05.AllAg.hESC_derived_fibroblasts [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Unc.PSC.05.AllAg.hESC_derived_fibroblasts hg19 Unclassified Pluripotent stem cell hESC derived... fibroblasts http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Unc.PSC.05.AllAg.hESC_derived_fibroblasts.bed ...

  17. File list: InP.PSC.10.AllAg.mESC_derived_neural_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.PSC.10.AllAg.mESC_derived_neural_cells mm9 Input control Pluripotent stem cell mESC derived...77,SRX1214070,SRX518051,SRX604258,SRX810565,SRX810564,SRX604259 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/InP.PSC.10.AllAg.mESC_derived_neural_cells.bed ...

  18. File list: ALL.PSC.05.AllAg.hESC_derived_fibroblasts [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.PSC.05.AllAg.hESC_derived_fibroblasts hg19 All antigens Pluripotent stem cell hESC derived...://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/ALL.PSC.05.AllAg.hESC_derived_fibroblasts.bed ...

  19. File list: DNS.PSC.05.AllAg.hESC_derived_fibroblasts [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available DNS.PSC.05.AllAg.hESC_derived_fibroblasts hg19 DNase-seq Pluripotent stem cell hESC derived... fibroblasts http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/DNS.PSC.05.AllAg.hESC_derived_fibroblasts.bed ...

  20. File list: His.PSC.20.AllAg.mESC_derived_neural_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available His.PSC.20.AllAg.mESC_derived_neural_cells mm9 Histone Pluripotent stem cell mESC derived...tp://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/His.PSC.20.AllAg.mESC_derived_neural_cells.bed ...

  1. File list: Pol.PSC.20.AllAg.iPS_derived_fibroblasts [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.PSC.20.AllAg.iPS_derived_fibroblasts hg19 RNA polymerase Pluripotent stem cell iPS derived... fibroblasts http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Pol.PSC.20.AllAg.iPS_derived_fibroblasts.bed ...

  2. File list: NoD.PSC.05.AllAg.hESC_derived_neural_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available NoD.PSC.05.AllAg.hESC_derived_neural_cells hg19 No description Pluripotent stem cell hESC derived...edbc.jp/kyushu-u/hg19/assembled/NoD.PSC.05.AllAg.hESC_derived_neural_cells.bed ...

  3. File list: NoD.PSC.50.AllAg.iPS_derived_neural_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available NoD.PSC.50.AllAg.iPS_derived_neural_cells hg19 No description Pluripotent stem cell iPS derived... neural cells http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/NoD.PSC.50.AllAg.iPS_derived_neural_cells.bed ...

  4. File list: InP.PSC.10.AllAg.hESC_derived_trophoblast_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.PSC.10.AllAg.hESC_derived_trophoblast_cells hg19 Input control Pluripotent stem cell hESC derived... trophoblast cells http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/InP.PSC.10.AllAg.hESC_derived_trophoblast_cells.bed ...

  5. File list: DNS.PSC.20.AllAg.hESC_derived_trophoblast_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available DNS.PSC.20.AllAg.hESC_derived_trophoblast_cells hg19 DNase-seq Pluripotent stem cell hESC derived... trophoblast cells SRX121240,SRX134724,SRX121254 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/DNS.PSC.20.AllAg.hESC_derived_trophoblast_cells.bed ...

  6. File list: Pol.PSC.50.AllAg.hESC_derived_neural_crests [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.PSC.50.AllAg.hESC_derived_neural_crests hg19 RNA polymerase Pluripotent stem cell hESC derived... neural crests http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Pol.PSC.50.AllAg.hESC_derived_neural_crests.bed ...

  7. File list: DNS.PSC.05.AllAg.iPS_derived_fibroblasts [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available DNS.PSC.05.AllAg.iPS_derived_fibroblasts hg19 DNase-seq Pluripotent stem cell iPS derived... fibroblasts http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/DNS.PSC.05.AllAg.iPS_derived_fibroblasts.bed ...

  8. File list: Pol.PSC.50.AllAg.hESC_derived_ectodermal_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.PSC.50.AllAg.hESC_derived_ectodermal_cells hg19 RNA polymerase Pluripotent stem cell hESC derived... ectodermal cells SRX702062 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Pol.PSC.50.AllAg.hESC_derived_ectodermal_cells.bed ...

  9. File list: Pol.PSC.10.AllAg.mESC_derived_neural_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.PSC.10.AllAg.mESC_derived_neural_cells mm9 RNA polymerase Pluripotent stem cell mESC derived...RX213760,SRX213764 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Pol.PSC.10.AllAg.mESC_derived_neural_cells.bed ...

  10. File list: Pol.PSC.10.AllAg.hESC_derived_fibroblasts [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.PSC.10.AllAg.hESC_derived_fibroblasts hg19 RNA polymerase Pluripotent stem cell hESC derived... fibroblasts http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Pol.PSC.10.AllAg.hESC_derived_fibroblasts.bed ...

  11. File list: ALL.PSC.10.AllAg.hESC_derived_ectodermal_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.PSC.10.AllAg.hESC_derived_ectodermal_cells hg19 All antigens Pluripotent stem cell hESC derived...p/kyushu-u/hg19/assembled/ALL.PSC.10.AllAg.hESC_derived_ectodermal_cells.bed ...

  12. File list: NoD.PSC.50.AllAg.hESC_derived_trophoblast_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available NoD.PSC.50.AllAg.hESC_derived_trophoblast_cells hg19 No description Pluripotent stem cell hESC derived...5230,SRX135232,SRX081157,SRX081154 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/NoD.PSC.50.AllAg.hESC_derived_trophoblast_cells.bed ...

  13. File list: Oth.PSC.20.AllAg.hESC_derived_fibroblasts [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.20.AllAg.hESC_derived_fibroblasts hg19 TFs and others Pluripotent stem cell hESC derived... fibroblasts http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Oth.PSC.20.AllAg.hESC_derived_fibroblasts.bed ...

  14. File list: Pol.PSC.20.AllAg.iPS_derived_neural_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.PSC.20.AllAg.iPS_derived_neural_cells hg19 RNA polymerase Pluripotent stem cell iPS derived... neural cells http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Pol.PSC.20.AllAg.iPS_derived_neural_cells.bed ...

  15. File list: NoD.PSC.50.AllAg.hESC_derived_fibroblasts [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available NoD.PSC.50.AllAg.hESC_derived_fibroblasts hg19 No description Pluripotent stem cell hESC derived... fibroblasts http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/NoD.PSC.50.AllAg.hESC_derived_fibroblasts.bed ...

  16. File list: InP.PSC.20.AllAg.hESC_derived_ectodermal_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.PSC.20.AllAg.hESC_derived_ectodermal_cells hg19 Input control Pluripotent stem cell hESC derived... ectodermal cells http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/InP.PSC.20.AllAg.hESC_derived_ectodermal_cells.bed ...

  17. File list: Pol.PSC.50.AllAg.iPS_derived_fibroblasts [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.PSC.50.AllAg.iPS_derived_fibroblasts hg19 RNA polymerase Pluripotent stem cell iPS derived... fibroblasts http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Pol.PSC.50.AllAg.iPS_derived_fibroblasts.bed ...

  18. File list: ALL.PSC.05.AllAg.hESC_derived_trophoblast_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.PSC.05.AllAg.hESC_derived_trophoblast_cells hg19 All antigens Pluripotent stem cell hESC derived...barchive.biosciencedbc.jp/kyushu-u/hg19/assembled/ALL.PSC.05.AllAg.hESC_derived_trophoblast_cells.bed ...

  19. File list: InP.PSC.05.AllAg.hESC_derived_trophoblast_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.PSC.05.AllAg.hESC_derived_trophoblast_cells hg19 Input control Pluripotent stem cell hESC derived... trophoblast cells http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/InP.PSC.05.AllAg.hESC_derived_trophoblast_cells.bed ...

  20. File list: Unc.PSC.10.AllAg.mESC_derived_neural_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Unc.PSC.10.AllAg.mESC_derived_neural_cells mm9 Unclassified Pluripotent stem cell mESC derived...,SRX213757,SRX213761 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Unc.PSC.10.AllAg.mESC_derived_neural_cells.bed ...

  1. File list: Pol.PSC.10.AllAg.hESC_derived_trophoblast_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.PSC.10.AllAg.hESC_derived_trophoblast_cells hg19 RNA polymerase Pluripotent stem cell hESC derived... trophoblast cells http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Pol.PSC.10.AllAg.hESC_derived_trophoblast_cells.bed ...

  2. File list: Pol.PSC.05.AllAg.hESC_derived_ectodermal_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.PSC.05.AllAg.hESC_derived_ectodermal_cells hg19 RNA polymerase Pluripotent stem cell hESC derived... ectodermal cells SRX702062 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Pol.PSC.05.AllAg.hESC_derived_ectodermal_cells.bed ...

  3. File list: DNS.PSC.10.AllAg.hESC_derived_trophoblast_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available DNS.PSC.10.AllAg.hESC_derived_trophoblast_cells hg19 DNase-seq Pluripotent stem cell hESC derived... trophoblast cells SRX121240,SRX134724,SRX121254 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/DNS.PSC.10.AllAg.hESC_derived_trophoblast_cells.bed ...

  4. File list: InP.PSC.20.AllAg.iPS_derived_neural_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.PSC.20.AllAg.iPS_derived_neural_cells hg19 Input control Pluripotent stem cell iPS derived... neural cells SRX702550 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/InP.PSC.20.AllAg.iPS_derived_neural_cells.bed ...

  5. File list: InP.PSC.50.AllAg.hESC_derived_trophoblast_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.PSC.50.AllAg.hESC_derived_trophoblast_cells hg19 Input control Pluripotent stem cell hESC derived... trophoblast cells http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/InP.PSC.50.AllAg.hESC_derived_trophoblast_cells.bed ...

  6. File list: Oth.PSC.10.AllAg.iPS_derived_neural_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.10.AllAg.iPS_derived_neural_cells hg19 TFs and others Pluripotent stem cell iPS derived...X968910 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Oth.PSC.10.AllAg.iPS_derived_neural_cells.bed ...

  7. File list: ALL.PSC.10.AllAg.iPS_derived_fibroblasts [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.PSC.10.AllAg.iPS_derived_fibroblasts hg19 All antigens Pluripotent stem cell iPS derived...4,SRX1099982,SRX1099970,SRX1099965,SRX1099961,SRX1099958,SRX1099949 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/ALL.PSC.10.AllAg.iPS_derived_fibroblasts.bed ...

  8. File list: InP.PSC.20.AllAg.hESC_derived_trophoblast_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.PSC.20.AllAg.hESC_derived_trophoblast_cells hg19 Input control Pluripotent stem cell hESC derived... trophoblast cells http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/InP.PSC.20.AllAg.hESC_derived_trophoblast_cells.bed ...

  9. File list: NoD.PSC.20.AllAg.hESC_derived_trophoblast_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available NoD.PSC.20.AllAg.hESC_derived_trophoblast_cells hg19 No description Pluripotent stem cell hESC derived...1157,SRX135234,SRX101257,SRX081154 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/NoD.PSC.20.AllAg.hESC_derived_trophoblast_cells.bed ...

  10. File list: DNS.PSC.10.AllAg.mESC_derived_neural_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available DNS.PSC.10.AllAg.mESC_derived_neural_cells mm9 DNase-seq Pluripotent stem cell mESC derived... neural cells http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/DNS.PSC.10.AllAg.mESC_derived_neural_cells.bed ...

  11. File list: DNS.PSC.20.AllAg.iPS_derived_neural_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available DNS.PSC.20.AllAg.iPS_derived_neural_cells hg19 DNase-seq Pluripotent stem cell iPS derived... neural cells http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/DNS.PSC.20.AllAg.iPS_derived_neural_cells.bed ...

  12. File list: His.PSC.10.AllAg.hESC_derived_ectodermal_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available His.PSC.10.AllAg.hESC_derived_ectodermal_cells hg19 Histone Pluripotent stem cell hESC derived... ectodermal cells http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/His.PSC.10.AllAg.hESC_derived_ectodermal_cells.bed ...

  13. File list: ALL.PSC.10.AllAg.mESC_derived_pancreatic_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.PSC.10.AllAg.mESC_derived_pancreatic_cells mm9 All antigens Pluripotent stem cell mESC derived pancreati...cedbc.jp/kyushu-u/mm9/assembled/ALL.PSC.10.AllAg.mESC_derived_pancreatic_cells.bed ...

  14. File list: NoD.PSC.20.AllAg.mESC_derived_pancreatic_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available NoD.PSC.20.AllAg.mESC_derived_pancreatic_cells mm9 No description Pluripotent stem cell mESC derived pancrea...tic cells http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/NoD.PSC.20.AllAg.mESC_derived_pancreatic_cells.bed ...

  15. File list: Unc.PSC.10.AllAg.mESC_derived_pancreatic_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Unc.PSC.10.AllAg.mESC_derived_pancreatic_cells mm9 Unclassified Pluripotent stem cell mESC derived pancreati...c cells http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Unc.PSC.10.AllAg.mESC_derived_pancreatic_cells.bed ...

  16. File list: His.PSC.20.AllAg.mESC_derived_pancreatic_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available His.PSC.20.AllAg.mESC_derived_pancreatic_cells mm9 Histone Pluripotent stem cell mESC derived pancreatic... cells SRX146012,SRX146011 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/His.PSC.20.AllAg.mESC_derived_pancreatic_cells.bed ...

  17. File list: InP.PSC.05.AllAg.mESC_derived_pancreatic_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.PSC.05.AllAg.mESC_derived_pancreatic_cells mm9 Input control Pluripotent stem cell mESC derived pancreat...ic cells SRX146010,SRX146009 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/InP.PSC.05.AllAg.mESC_derived_pancreatic_cells.bed ...

  18. File list: DNS.PSC.50.AllAg.mESC_derived_pancreatic_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available DNS.PSC.50.AllAg.mESC_derived_pancreatic_cells mm9 DNase-seq Pluripotent stem cell mESC derived pancreatic... cells SRX404487 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/DNS.PSC.50.AllAg.mESC_derived_pancreatic_cells.bed ...

  19. File list: NoD.PSC.50.AllAg.mESC_derived_pancreatic_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available NoD.PSC.50.AllAg.mESC_derived_pancreatic_cells mm9 No description Pluripotent stem cell mESC derived pancrea...tic cells http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/NoD.PSC.50.AllAg.mESC_derived_pancreatic_cells.bed ...

  20. File list: Pol.PSC.10.AllAg.mESC_derived_pancreatic_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.PSC.10.AllAg.mESC_derived_pancreatic_cells mm9 RNA polymerase Pluripotent stem cell mESC derived pancrea...tic cells http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Pol.PSC.10.AllAg.mESC_derived_pancreatic_cells.bed ...

  1. File list: Oth.PSC.10.AllAg.mESC_derived_pancreatic_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.10.AllAg.mESC_derived_pancreatic_cells mm9 TFs and others Pluripotent stem cell mESC derived pancrea...tic cells http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.10.AllAg.mESC_derived_pancreatic_cells.bed ...

  2. File list: ALL.PSC.50.AllAg.mESC_derived_pancreatic_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.PSC.50.AllAg.mESC_derived_pancreatic_cells mm9 All antigens Pluripotent stem cell mESC derived pancreati...cedbc.jp/kyushu-u/mm9/assembled/ALL.PSC.50.AllAg.mESC_derived_pancreatic_cells.bed ...

  3. File list: DNS.PSC.20.AllAg.mESC_derived_pancreatic_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available DNS.PSC.20.AllAg.mESC_derived_pancreatic_cells mm9 DNase-seq Pluripotent stem cell mESC derived pancreatic... cells SRX404487 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/DNS.PSC.20.AllAg.mESC_derived_pancreatic_cells.bed ...

  4. File list: Unc.PSC.50.AllAg.mESC_derived_pancreatic_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Unc.PSC.50.AllAg.mESC_derived_pancreatic_cells mm9 Unclassified Pluripotent stem cell mESC derived pancreati...c cells http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Unc.PSC.50.AllAg.mESC_derived_pancreatic_cells.bed ...

  5. File list: ALL.PSC.05.AllAg.mESC_derived_pancreatic_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.PSC.05.AllAg.mESC_derived_pancreatic_cells mm9 All antigens Pluripotent stem cell mESC derived pancreati...cedbc.jp/kyushu-u/mm9/assembled/ALL.PSC.05.AllAg.mESC_derived_pancreatic_cells.bed ...

  6. File list: His.PSC.50.AllAg.mESC_derived_pancreatic_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available His.PSC.50.AllAg.mESC_derived_pancreatic_cells mm9 Histone Pluripotent stem cell mESC derived pancreatic... cells SRX146012,SRX146011 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/His.PSC.50.AllAg.mESC_derived_pancreatic_cells.bed ...

  7. File list: NoD.PSC.05.AllAg.mESC_derived_pancreatic_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available NoD.PSC.05.AllAg.mESC_derived_pancreatic_cells mm9 No description Pluripotent stem cell mESC derived pancrea...tic cells http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/NoD.PSC.05.AllAg.mESC_derived_pancreatic_cells.bed ...

  8. File list: Pol.PSC.50.AllAg.mESC_derived_pancreatic_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.PSC.50.AllAg.mESC_derived_pancreatic_cells mm9 RNA polymerase Pluripotent stem cell mESC derived pancrea...tic cells http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Pol.PSC.50.AllAg.mESC_derived_pancreatic_cells.bed ...

  9. File list: Unc.PSC.05.AllAg.mESC_derived_pancreatic_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Unc.PSC.05.AllAg.mESC_derived_pancreatic_cells mm9 Unclassified Pluripotent stem cell mESC derived pancreati...c cells http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Unc.PSC.05.AllAg.mESC_derived_pancreatic_cells.bed ...

  10. File list: DNS.PSC.05.AllAg.mESC_derived_pancreatic_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available DNS.PSC.05.AllAg.mESC_derived_pancreatic_cells mm9 DNase-seq Pluripotent stem cell mESC derived pancreatic... cells SRX404487 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/DNS.PSC.05.AllAg.mESC_derived_pancreatic_cells.bed ...

  11. File list: InP.PSC.20.AllAg.mESC_derived_pancreatic_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.PSC.20.AllAg.mESC_derived_pancreatic_cells mm9 Input control Pluripotent stem cell mESC derived pancreat...ic cells SRX146010,SRX146009 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/InP.PSC.20.AllAg.mESC_derived_pancreatic_cells.bed ...

  12. File list: ALL.PSC.20.AllAg.mESC_derived_pancreatic_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.PSC.20.AllAg.mESC_derived_pancreatic_cells mm9 All antigens Pluripotent stem cell mESC derived pancreati...cedbc.jp/kyushu-u/mm9/assembled/ALL.PSC.20.AllAg.mESC_derived_pancreatic_cells.bed ...

  13. File list: His.PSC.05.AllAg.mESC_derived_pancreatic_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available His.PSC.05.AllAg.mESC_derived_pancreatic_cells mm9 Histone Pluripotent stem cell mESC derived pancreatic... cells SRX146012,SRX146011 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/His.PSC.05.AllAg.mESC_derived_pancreatic_cells.bed ...

  14. File list: NoD.PSC.10.AllAg.mESC_derived_pancreatic_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available NoD.PSC.10.AllAg.mESC_derived_pancreatic_cells mm9 No description Pluripotent stem cell mESC derived pancrea...tic cells http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/NoD.PSC.10.AllAg.mESC_derived_pancreatic_cells.bed ...

  15. File list: His.PSC.10.AllAg.mESC_derived_pancreatic_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available His.PSC.10.AllAg.mESC_derived_pancreatic_cells mm9 Histone Pluripotent stem cell mESC derived pancreatic... cells SRX146012,SRX146011 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/His.PSC.10.AllAg.mESC_derived_pancreatic_cells.bed ...

  16. File list: InP.PSC.10.AllAg.mESC_derived_pancreatic_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.PSC.10.AllAg.mESC_derived_pancreatic_cells mm9 Input control Pluripotent stem cell mESC derived pancreat...ic cells SRX146010,SRX146009 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/InP.PSC.10.AllAg.mESC_derived_pancreatic_cells.bed ...

  17. File list: Oth.PSC.05.AllAg.mESC_derived_pancreatic_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.05.AllAg.mESC_derived_pancreatic_cells mm9 TFs and others Pluripotent stem cell mESC derived pancrea...tic cells http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.05.AllAg.mESC_derived_pancreatic_cells.bed ...

  18. File list: Oth.PSC.50.AllAg.mESC_derived_pancreatic_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.50.AllAg.mESC_derived_pancreatic_cells mm9 TFs and others Pluripotent stem cell mESC derived pancrea...tic cells http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.50.AllAg.mESC_derived_pancreatic_cells.bed ...

  19. File list: Oth.PSC.20.AllAg.mESC_derived_pancreatic_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.20.AllAg.mESC_derived_pancreatic_cells mm9 TFs and others Pluripotent stem cell mESC derived pancrea...tic cells http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.20.AllAg.mESC_derived_pancreatic_cells.bed ...

  20. File list: DNS.PSC.10.AllAg.mESC_derived_pancreatic_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available DNS.PSC.10.AllAg.mESC_derived_pancreatic_cells mm9 DNase-seq Pluripotent stem cell mESC derived pancreatic... cells SRX404487 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/DNS.PSC.10.AllAg.mESC_derived_pancreatic_cells.bed ...

  1. File list: Pol.PSC.05.AllAg.mESC_derived_pancreatic_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.PSC.05.AllAg.mESC_derived_pancreatic_cells mm9 RNA polymerase Pluripotent stem cell mESC derived pancrea...tic cells http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Pol.PSC.05.AllAg.mESC_derived_pancreatic_cells.bed ...

  2. File list: InP.PSC.50.AllAg.mESC_derived_pancreatic_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.PSC.50.AllAg.mESC_derived_pancreatic_cells mm9 Input control Pluripotent stem cell mESC derived pancreat...ic cells SRX146010,SRX146009 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/InP.PSC.50.AllAg.mESC_derived_pancreatic_cells.bed ...

  3. File list: Unc.PSC.20.AllAg.mESC_derived_pancreatic_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Unc.PSC.20.AllAg.mESC_derived_pancreatic_cells mm9 Unclassified Pluripotent stem cell mESC derived pancreati...c cells http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Unc.PSC.20.AllAg.mESC_derived_pancreatic_cells.bed ...

  4. File list: NoD.PSC.10.AllAg.mESCs,_differentiated [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available NoD.PSC.10.AllAg.mESCs,_differentiated mm9 No description Pluripotent stem cell mESCs, different...iated http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/NoD.PSC.10.AllAg.mESCs,_differentiated.bed ...

  5. File list: InP.PSC.50.AllAg.mESCs,_differentiated [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.PSC.50.AllAg.mESCs,_differentiated mm9 Input control Pluripotent stem cell mESCs, different...,SRX388447 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/InP.PSC.50.AllAg.mESCs,_differentiated.bed ...

  6. File list: NoD.PSC.20.AllAg.mESCs,_differentiated [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available NoD.PSC.20.AllAg.mESCs,_differentiated mm9 No description Pluripotent stem cell mESCs, different...iated http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/NoD.PSC.20.AllAg.mESCs,_differentiated.bed ...

  7. File list: InP.PSC.10.AllAg.mESCs,_differentiated [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.PSC.10.AllAg.mESCs,_differentiated mm9 Input control Pluripotent stem cell mESCs, different...,SRX388447 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/InP.PSC.10.AllAg.mESCs,_differentiated.bed ...

  8. File list: InP.PSC.20.AllAg.mESCs,_differentiated [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.PSC.20.AllAg.mESCs,_differentiated mm9 Input control Pluripotent stem cell mESCs, different...,SRX388447 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/InP.PSC.20.AllAg.mESCs,_differentiated.bed ...

  9. File list: NoD.PSC.05.AllAg.mESCs,_differentiated [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available NoD.PSC.05.AllAg.mESCs,_differentiated mm9 No description Pluripotent stem cell mESCs, different...iated http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/NoD.PSC.05.AllAg.mESCs,_differentiated.bed ...

  10. File list: NoD.PSC.05.AllAg.iPS_derived_neural_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available NoD.PSC.05.AllAg.iPS_derived_neural_cells hg19 No description Pluripotent stem cell iPS derived neural... cells http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/NoD.PSC.05.AllAg.iPS_derived_neural_cells.bed ...

  11. File list: Oth.PSC.05.AllAg.hESC_derived_neural_crests [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.05.AllAg.hESC_derived_neural_crests hg19 TFs and others Pluripotent stem cell hESC derived neural...X1091546,SRX1091550,SRX059360,SRX059368,SRX059367 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Oth.PSC.05.AllAg.hESC_derived_neural_crests.bed ...

  12. File list: His.PSC.50.AllAg.iPS_derived_neural_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available His.PSC.50.AllAg.iPS_derived_neural_cells hg19 Histone Pluripotent stem cell iPS derived neural...archive.biosciencedbc.jp/kyushu-u/hg19/assembled/His.PSC.50.AllAg.iPS_derived_neural_cells.bed ...

  13. File list: Oth.PSC.10.AllAg.hESC_derived_neural_crests [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.10.AllAg.hESC_derived_neural_crests hg19 TFs and others Pluripotent stem cell hESC derived neural...X1091546,SRX1091550,SRX059360,SRX059368,SRX059367 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Oth.PSC.10.AllAg.hESC_derived_neural_crests.bed ...

  14. File list: DNS.PSC.10.AllAg.iPS_derived_neural_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available DNS.PSC.10.AllAg.iPS_derived_neural_cells hg19 DNase-seq Pluripotent stem cell iPS derived neural... cells http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/DNS.PSC.10.AllAg.iPS_derived_neural_cells.bed ...

  15. File list: Pol.PSC.10.AllAg.hESC_derived_neural_crests [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.PSC.10.AllAg.hESC_derived_neural_crests hg19 RNA polymerase Pluripotent stem cell hESC derived neural... crests http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Pol.PSC.10.AllAg.hESC_derived_neural_crests.bed ...

  16. File list: InP.PSC.10.AllAg.hESC_derived_neural_crests [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.PSC.10.AllAg.hESC_derived_neural_crests hg19 Input control Pluripotent stem cell hESC derived neural... crests SRX1091573,SRX059369,SRX059361 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/InP.PSC.10.AllAg.hESC_derived_neural_crests.bed ...

  17. File list: Pol.PSC.05.AllAg.hESC_derived_neural_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.PSC.05.AllAg.hESC_derived_neural_cells hg19 RNA polymerase Pluripotent stem cell hESC derived neural... cells SRX190259 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Pol.PSC.05.AllAg.hESC_derived_neural_cells.bed ...

  18. File list: His.PSC.05.AllAg.mESC_derived_neural_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available His.PSC.05.AllAg.mESC_derived_neural_cells mm9 Histone Pluripotent stem cell mESC derived neural...tp://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/His.PSC.05.AllAg.mESC_derived_neural_cells.bed ...

  19. File list: NoD.PSC.20.AllAg.hESC_derived_neural_crests [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available NoD.PSC.20.AllAg.hESC_derived_neural_crests hg19 No description Pluripotent stem cell hESC derived neural... crests http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/NoD.PSC.20.AllAg.hESC_derived_neural_crests.bed ...

  20. File list: Pol.PSC.20.AllAg.mESC_derived_neural_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.PSC.20.AllAg.mESC_derived_neural_cells mm9 RNA polymerase Pluripotent stem cell mESC derived neural...RX213760,SRX213764 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Pol.PSC.20.AllAg.mESC_derived_neural_cells.bed ...

  1. File list: Oth.PSC.50.AllAg.mESC_derived_neural_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.50.AllAg.mESC_derived_neural_cells mm9 TFs and others Pluripotent stem cell mESC derived neural...13762,SRX213759,SRX352995 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.50.AllAg.mESC_derived_neural_cells.bed ...

  2. File list: ALL.PSC.10.AllAg.iPS_derived_neural_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.PSC.10.AllAg.iPS_derived_neural_cells hg19 All antigens Pluripotent stem cell iPS derived neural...hive.biosciencedbc.jp/kyushu-u/hg19/assembled/ALL.PSC.10.AllAg.iPS_derived_neural_cells.bed ...

  3. File list: DNS.PSC.10.AllAg.hESC_derived_neural_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available DNS.PSC.10.AllAg.hESC_derived_neural_cells hg19 DNase-seq Pluripotent stem cell hESC derived neural... cells SRX121241,SRX134721 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/DNS.PSC.10.AllAg.hESC_derived_neural_cells.bed ...

  4. File list: Unc.PSC.10.AllAg.iPS_derived_neural_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Unc.PSC.10.AllAg.iPS_derived_neural_cells hg19 Unclassified Pluripotent stem cell iPS derived neural... cells http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Unc.PSC.10.AllAg.iPS_derived_neural_cells.bed ...

  5. File list: Unc.PSC.50.AllAg.mESC_derived_neural_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Unc.PSC.50.AllAg.mESC_derived_neural_cells mm9 Unclassified Pluripotent stem cell mESC derived neural...,SRX213761,SRX213757 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Unc.PSC.50.AllAg.mESC_derived_neural_cells.bed ...

  6. File list: DNS.PSC.20.AllAg.mESC_derived_neural_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available DNS.PSC.20.AllAg.mESC_derived_neural_cells mm9 DNase-seq Pluripotent stem cell mESC derived neural... cells http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/DNS.PSC.20.AllAg.mESC_derived_neural_cells.bed ...

  7. File list: Pol.PSC.50.AllAg.mESC_derived_neural_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.PSC.50.AllAg.mESC_derived_neural_cells mm9 RNA polymerase Pluripotent stem cell mESC derived neural...RX213760,SRX213764 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Pol.PSC.50.AllAg.mESC_derived_neural_cells.bed ...

  8. File list: DNS.PSC.05.AllAg.iPS_derived_neural_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available DNS.PSC.05.AllAg.iPS_derived_neural_cells hg19 DNase-seq Pluripotent stem cell iPS derived neural... cells http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/DNS.PSC.05.AllAg.iPS_derived_neural_cells.bed ...

  9. File list: DNS.PSC.50.AllAg.mESC_derived_neural_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available DNS.PSC.50.AllAg.mESC_derived_neural_cells mm9 DNase-seq Pluripotent stem cell mESC derived neural... cells http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/DNS.PSC.50.AllAg.mESC_derived_neural_cells.bed ...

  10. File list: NoD.PSC.20.AllAg.mESC_derived_neural_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available NoD.PSC.20.AllAg.mESC_derived_neural_cells mm9 No description Pluripotent stem cell mESC derived neural... cells SRX440731,SRX440736 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/NoD.PSC.20.AllAg.mESC_derived_neural_cells.bed ...

  11. File list: DNS.PSC.05.AllAg.hESC_derived_neural_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available DNS.PSC.05.AllAg.hESC_derived_neural_cells hg19 DNase-seq Pluripotent stem cell hESC derived neural... cells SRX121241,SRX134721 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/DNS.PSC.05.AllAg.hESC_derived_neural_cells.bed ...

  12. File list: Oth.PSC.20.AllAg.mESC_derived_neural_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.20.AllAg.mESC_derived_neural_cells mm9 TFs and others Pluripotent stem cell mESC derived neural...52996,SRX213763,SRX213758 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.20.AllAg.mESC_derived_neural_cells.bed ...

  13. File list: Unc.PSC.20.AllAg.hESC_derived_neural_crests [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Unc.PSC.20.AllAg.hESC_derived_neural_crests hg19 Unclassified Pluripotent stem cell hESC derived neural... crests SRX059366 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Unc.PSC.20.AllAg.hESC_derived_neural_crests.bed ...

  14. File list: Unc.PSC.20.AllAg.iPS_derived_neural_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Unc.PSC.20.AllAg.iPS_derived_neural_cells hg19 Unclassified Pluripotent stem cell iPS derived neural... cells http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Unc.PSC.20.AllAg.iPS_derived_neural_cells.bed ...

  15. File list: Pol.PSC.20.AllAg.hESC_derived_neural_crests [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.PSC.20.AllAg.hESC_derived_neural_crests hg19 RNA polymerase Pluripotent stem cell hESC derived neural... crests http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Pol.PSC.20.AllAg.hESC_derived_neural_crests.bed ...

  16. File list: Oth.PSC.05.AllAg.mESC_derived_neural_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.05.AllAg.mESC_derived_neural_cells mm9 TFs and others Pluripotent stem cell mESC derived neural...10563,SRX213763,SRX352996 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.05.AllAg.mESC_derived_neural_cells.bed ...

  17. File list: Oth.PSC.05.AllAg.iPS_derived_neural_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.05.AllAg.iPS_derived_neural_cells hg19 TFs and others Pluripotent stem cell iPS derived neural...X968908 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Oth.PSC.05.AllAg.iPS_derived_neural_cells.bed ...

  18. File list: NoD.PSC.50.AllAg.mESC_derived_neural_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available NoD.PSC.50.AllAg.mESC_derived_neural_cells mm9 No description Pluripotent stem cell mESC derived neural... cells SRX440736,SRX440731 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/NoD.PSC.50.AllAg.mESC_derived_neural_cells.bed ...

  19. File list: InP.PSC.50.AllAg.hESC_derived_neural_crests [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.PSC.50.AllAg.hESC_derived_neural_crests hg19 Input control Pluripotent stem cell hESC derived neural... crests SRX1091573,SRX059369,SRX059361 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/InP.PSC.50.AllAg.hESC_derived_neural_crests.bed ...

  20. File list: InP.PSC.05.AllAg.hESC_derived_neural_crests [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.PSC.05.AllAg.hESC_derived_neural_crests hg19 Input control Pluripotent stem cell hESC derived neural... crests SRX1091573,SRX059369,SRX059361 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/InP.PSC.05.AllAg.hESC_derived_neural_crests.bed ...