WorldWideScience

Sample records for ps1 3pi sky

  1. The Pan-STARRS PS1 Image Processing Pipeline

    Science.gov (United States)

    Magnier, E.

    The Pan-STARRS PS1 Image Processing Pipeline (IPP) performs the image processing and data analysis tasks needed to enable the scientific use of the images obtained by the Pan-STARRS PS1 prototype telescope. The primary goals of the IPP are to process the science images from the Pan-STARRS telescopes and make the results available to other systems within Pan-STARRS. It also is responsible for combining all of the science images in a given filter into a single representation of the non-variable component of the night sky defined as the "Static Sky". To achieve these goals, the IPP also performs other analysis functions to generate the calibrations needed in the science image processing, and to occasionally use the derived data to generate improved astrometric and photometric reference catalogs. It also provides the infrastructure needed to store the incoming data and the resulting data products. The IPP inherits lessons learned, and in some cases code and prototype code, from several other astronomy image analysis systems, including Imcat (Kaiser), the Sloan Digital Sky Survey (REF), the Elixir system (Magnier & Cuillandre), and Vista (Tonry). Imcat and Vista have a large number of robust image processing functions. SDSS has demonstrated a working analysis pipeline and large-scale databasesystem for a dedicated project. The Elixir system has demonstrated an automatic image processing system and an object database system for operational usage. This talk will present an overview of the IPP architecture, functional flow, code development structure, and selected analysis algorithms. Also discussed is the HW highly parallel HW configuration necessary to support PS1 operational requirements. Finally, results are presented of the processing of images collected during PS1 early commissioning tasks utilizing the Pan-STARRS Test Camera #3.

  2. Cusps in K->3{pi} decays

    Energy Technology Data Exchange (ETDEWEB)

    Colangelo, G. [Institute for Theoretical Physics, University of Bern, Sidlerstr. 5, CH-3012 Bern (Switzerland); Gasser, J. [Institute for Theoretical Physics, University of Bern, Sidlerstr. 5, CH-3012 Bern (Switzerland); Kubis, B. [Helmholtz-Institut fuer Strahlen- und Kernphysik, Universitaet Bonn, Nussallee 14-16, D-53115 Bonn (Germany); Rusetsky, A. [Helmholtz-Institut fuer Strahlen- und Kernphysik, Universitaet Bonn, Nussallee 14-16, D-53115 Bonn (Germany)]. E-mail: rusetsky@itkp.uni-bonn.de

    2006-07-06

    pion mass difference generates a pronounced cusp in K->3{pi} decays. As has recently been pointed out by Cabibbo and Isidori, an accurate measurement of the cusp may allow one to pin down the S-wave {pi}{pi} scattering lengths to high precision. Here, we present and illustrate an effective field theory framework that allows one to determine the structure of this cusp in a straightforward manner. The strictures imposed by analyticity and unitarity are respected automatically.

  3. Dispersive analysis of {omega}{yields}3{pi} and {phi}{yields}3{pi} decays

    Energy Technology Data Exchange (ETDEWEB)

    Niecknig, Franz; Kubis, Bastian; Schneider, Sebastian P. [Universitaet Bonn, Helmholtz-Institut fuer Strahlen- und Kernphysik (Theorie) and Bethe Center for Theoretical Physics, Bonn (Germany)

    2012-05-15

    We study the three-pion decays of the lightest isoscalar vector mesons, {omega} and {phi}, in a dispersive framework that allows for a consistent description of final-state interactions between all three pions. Our results are solely dependent on the phenomenological input for the pion-pion P-wave scattering phase shift. We predict the Dalitz plot distributions for both decays and compare our findings to recent measurements of the {phi}{yields}3{pi} Dalitz plot by the KLOE and CMD-2 collaborations. Dalitz plot parameters for future precision measurements of {omega}{yields}3{pi} are predicted. We also calculate the {pi}{pi} P-wave inelasticity contribution from {omega}{pi} intermediate states. (orig.)

  4. Machine-learned Identification of RR Lyrae Stars from Sparse, Multi-band Data: The PS1 Sample

    Science.gov (United States)

    Sesar, Branimir; Hernitschek, Nina; Mitrović, Sandra; Ivezić, Željko; Rix, Hans-Walter; Cohen, Judith G.; Bernard, Edouard J.; Grebel, Eva K.; Martin, Nicolas F.; Schlafly, Edward F.; Burgett, William S.; Draper, Peter W.; Flewelling, Heather; Kaiser, Nick; Kudritzki, Rolf P.; Magnier, Eugene A.; Metcalfe, Nigel; Tonry, John L.; Waters, Christopher

    2017-05-01

    RR Lyrae stars may be the best practical tracers of Galactic halo (sub-)structure and kinematics. The PanSTARRS1 (PS1) 3π survey offers multi-band, multi-epoch, precise photometry across much of the sky, but a robust identification of RR Lyrae stars in this data set poses a challenge, given PS1's sparse, asynchronous multi-band light curves (≲ 12 epochs in each of five bands, taken over a 4.5 year period). We present a novel template fitting technique that uses well-defined and physically motivated multi-band light curves of RR Lyrae stars, and demonstrate that we get accurate period estimates, precise to 2 s in > 80 % of cases. We augment these light-curve fits with other features from photometric time-series and provide them to progressively more detailed machine-learned classification models. From these models, we are able to select the widest (three-fourths of the sky) and deepest (reaching 120 kpc) sample of RR Lyrae stars to date. The PS1 sample of ˜45,000 RRab stars is pure (90%) and complete (80% at 80 kpc) at high galactic latitudes. It also provides distances that are precise to 3%, measured with newly derived period-luminosity relations for optical/near-infrared PS1 bands. With the addition of proper motions from Gaia and radial velocity measurements from multi-object spectroscopic surveys, we expect the PS1 sample of RR Lyrae stars to become the premier source for studying the structure, kinematics, and the gravitational potential of the Galactic halo. The techniques presented in this study should translate well to other sparse, multi-band data sets, such as those produced by the Dark Energy Survey and the upcoming Large Synoptic Survey Telescope Galactic plane sub-survey.

  5. VizieR Online Data Catalog: RR Lyrae stars from the PS1 3π survey (Sesar+, 2017)

    Science.gov (United States)

    Sesar, B.; Hernitschek, N.; Mitrovic, S.; Ivezic, Z.; Rix, H.-W.; Cohen, J. G.; Bernard, E. J.; Grebel, E. K.; Martin, N. F.; Schlafly, E. F.; Burgett, W. S.; Draper, P. W.; Flewelling, H.; Kaiser, N.; Kudritzki, R. P.; Magnier, E. A.; Metcalfe, N.; Tonry, J. L.; Waters, C.

    2018-04-01

    Building on the work by Hernitschek+ (2016, J/ApJ/817/73), in this paper, we use the final PS1 data release (PV3) to significantly increase the completeness and purity of the PS1 sample of RR Lyrae stars. Pan-STARRS1 (PS1; Kaiser+ 2010, see II/349) is a wide-field optical/near-IR survey telescope system located at the Haleakala Observatory on the island of Maui in Hawai'i. The largest survey undertaken by the telescope, the PS1 3π survey (Chambers K.C. 2011, BAAS, 43, 113.01), has observed the entire sky north of decl. -30° in five filter bands, reaching 5σ single-epoch depths of about 22.0, 22.0, 21.9, 21.0, and 19.8mag in gP1, rP1, iP1, zP1, and yP1 bands, respectively. The uncertainty in photometric calibration of the survey is <~0.01mag, and the astrometric precision of single-epoch detections is 10mas. (4 data files).

  6. Rab21, a Novel PS1 Interactor, Regulates γ-Secretase Activity via PS1 Subcellular Distribution.

    Science.gov (United States)

    Sun, Zhenzhen; Xie, Yujie; Chen, Yintong; Yang, Qinghu; Quan, Zhenzhen; Dai, Rongji; Qing, Hong

    2018-05-01

    γ-Secretase has been a therapeutical target for its key role in cleaving APP to generate β-amyloid (Aβ), the primary constituents of senile plaques and a hallmark of Alzheimer's disease (AD) pathology. Recently, γ-secretase-associating proteins showed promising role in specifically modulating APP processing while sparing Notch signaling; however, the underlying mechanism is still unclear. A co-immunoprecipitation (Co-IP) coupled with mass spectrometry proteomic assay for Presenilin1 (PS1, the catalytic subunit of γ-secretase) was firstly conducted to find more γ-secretase-associating proteins. Gene ontology analysis of these results identified Rab21 as a potential PS1 interacting protein, and the interaction between them was validated by reciprocal Co-IP and immunofluorescence assay. Then, molecular and biochemical methods were used to investigate the effect of Rab21 on APP processing. Results showed that overexpression of Rab21 enhanced Aβ generation, while silencing of Rab21 reduced the accumulation of Aβ, which resulted due to change in γ-secretase activity rather than α- or β-secretase. Finally, we demonstrated that Rab21 had no effect on γ-secretase complex synthesis or metabolism but enhanced PS1 endocytosis and translocation to late endosome/lysosome. In conclusion, we identified a novel γ-secretase-associating protein Rab21 and illustrate that Rab21 promotes γ-secretase internalization and translocation to late endosome/lysosome. Moreover, silencing of Rab21 decreases the γ-secretase activity in APP processing thus production of Aβ. All these results open new gateways towards the understanding of γ-secretase-associating proteins in APP processing and make inhibition of Rab21 a promising strategy for AD therapy.

  7. Electromagnetic corrections in {eta}{yields}3{pi} decays

    Energy Technology Data Exchange (ETDEWEB)

    Ditsche, Christoph; Kubis, Bastian [Universitaet Bonn, Helmholtz-Institut fuer Strahlen- und Kernphysik (Theorie) and Bethe Center for Theoretical Physics, Bonn (Germany); Meissner, Ulf G. [Universitaet Bonn, Helmholtz-Institut fuer Strahlen- und Kernphysik (Theorie) and Bethe Center for Theoretical Physics, Bonn (Germany); Forschungszentrum Juelich, Institut fuer Kernphysik (Theorie), Institute for Advanced Simulations, and Juelich Center for Hadron Physics, Juelich (Germany)

    2009-03-15

    We re-evaluate the electromagnetic corrections to {eta}{yields}3{pi} decays at next-to-leading order in the chiral expansion, arguing that effects of order e{sup 2}(m{sub u}-m{sub d}) disregarded so far are not negligible compared to other contributions of order e {sup 2} times a light-quark mass. Despite the appearance of the Coulomb pole in {eta}{yields}{pi}{sup +}{pi}{sup -}{pi}{sup 0} and cusps in {eta}{yields}3{pi}{sup 0}, the overall corrections remain small. (orig.)

  8. Disruption of a red giant star by a supermassive black hole and the case of PS1-10jh

    Energy Technology Data Exchange (ETDEWEB)

    Bogdanović, Tamara; Cheng, Roseanne M. [Center for Relativistic Astrophysics, School of Physics, Georgia Tech, Atlanta, GA 30332 (United States); Amaro-Seoane, Pau, E-mail: tamarab@gatech.edu, E-mail: rcheng@gatech.edu, E-mail: Pau.Amaro-Seoane@aei.mpg.de [Max Planck Institut für Gravitationsphysik (Albert-Einstein-Institut), D-14476 Potsdam (Germany)

    2014-06-20

    The development of a new generation of theoretical models for tidal disruptions is timely, as increasingly diverse events are being captured in surveys of the transient sky. Recently, Gezari et al. reported a discovery of a new class of tidal disruption events: the disruption of a helium-rich stellar core, thought to be a remnant of a red giant (RG) star. Motivated by this discovery and in anticipation of others, we consider tidal interaction of an RG star with a supermassive black hole (SMBH) which leads to the stripping of the stellar envelope and subsequent inspiral of the compact core toward the black hole. Once the stellar envelope is removed the inspiral of the core is driven by tidal heating as well as the emission of gravitational radiation until the core either falls into the SMBH or is tidally disrupted. In the case of the tidal disruption candidate PS1-10jh, we find that there is a set of orbital solutions at high eccentricities in which the tidally stripped hydrogen envelope is accreted by the SMBH before the helium core is disrupted. This places the RG core in a portion of parameter space where strong tidal heating can lift the degeneracy of the compact remnant and disrupt it before it reaches the tidal radius. We consider how this sequence of events explains the puzzling absence of the hydrogen emission lines from the spectrum of PS1-10jh and gives rise to its other observational features.

  9. Disruption of a red giant star by a supermassive black hole and the case of PS1-10jh

    International Nuclear Information System (INIS)

    Bogdanović, Tamara; Cheng, Roseanne M.; Amaro-Seoane, Pau

    2014-01-01

    The development of a new generation of theoretical models for tidal disruptions is timely, as increasingly diverse events are being captured in surveys of the transient sky. Recently, Gezari et al. reported a discovery of a new class of tidal disruption events: the disruption of a helium-rich stellar core, thought to be a remnant of a red giant (RG) star. Motivated by this discovery and in anticipation of others, we consider tidal interaction of an RG star with a supermassive black hole (SMBH) which leads to the stripping of the stellar envelope and subsequent inspiral of the compact core toward the black hole. Once the stellar envelope is removed the inspiral of the core is driven by tidal heating as well as the emission of gravitational radiation until the core either falls into the SMBH or is tidally disrupted. In the case of the tidal disruption candidate PS1-10jh, we find that there is a set of orbital solutions at high eccentricities in which the tidally stripped hydrogen envelope is accreted by the SMBH before the helium core is disrupted. This places the RG core in a portion of parameter space where strong tidal heating can lift the degeneracy of the compact remnant and disrupt it before it reaches the tidal radius. We consider how this sequence of events explains the puzzling absence of the hydrogen emission lines from the spectrum of PS1-10jh and gives rise to its other observational features.

  10. Characterization of cucurbita maxima phloem serpin-1 (CmPS-1). A developmentally regulated elastase inhibitor.

    Science.gov (United States)

    Yoo, B C; Aoki, K; Xiang, Y; Campbell, L R; Hull, R J; Xoconostle-Cázares, B; Monzer, J; Lee, J Y; Ullman, D E; Lucas, W J

    2000-11-10

    We report on the molecular, biochemical, and functional characterization of Cucurbita maxima phloem serpin-1 (CmPS-1), a novel 42-kDa serine proteinase inhibitor that is developmentally regulated and has anti-elastase properties. CmPS-1 was purified to near homogeneity from C. maxima (pumpkin) phloem exudate and, based on microsequence analysis, the cDNA encoding CmPS-1 was cloned. The association rate constant (k(a)) of phloem-purified and recombinant His(6)-tagged CmPS-1 for elastase was 3.5 +/- 1.6 x 10(5) and 2.7 +/- 0.4 x 10(5) m(-)(1) s(-)(1), respectively. The fraction of complex-forming CmPS-1, X(inh), was estimated at 79%. CmPS-1 displayed no detectable inhibitory properties against chymotrypsin, trypsin, or thrombin. The elastase cleavage sites within the reactive center loop of CmPS-1 were determined to be Val(347)-Gly(348) and Val(350)-Ser(351) with a 3:2 molar ratio. In vivo feeding assays conducted with the piercing-sucking aphid, Myzus persicae, established a close correlation between the developmentally regulated increase in CmPS-1 within the phloem sap and the reduced ability of these insects to survive and reproduce on C. maxima. However, in vitro feeding experiments, using purified phloem CmPS-1, failed to demonstrate a direct effect on aphid survival. Likely roles of this novel phloem serpin in defense against insects/pathogens are discussed.

  11. Radiative corrections in K{yields}3{pi} decays

    Energy Technology Data Exchange (ETDEWEB)

    Bissegger, M. [Institute for Theoretical Physics, University of Bern, Sidlerstr. 5, CH-3012 Bern (Switzerland); Fuhrer, A. [Institute for Theoretical Physics, University of Bern, Sidlerstr. 5, CH-3012 Bern (Switzerland); Physics Department, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0319 (United States); Gasser, J. [Institute for Theoretical Physics, University of Bern, Sidlerstr. 5, CH-3012 Bern (Switzerland); Kubis, B. [Helmholtz-Institut fuer Strahlen-und Kernphysik, Universitaet Bonn, Nussallee 14-16, D-53115 Bonn (Germany)], E-mail: kubis@itkp.uni-bonn.de; Rusetsky, A. [Helmholtz-Institut fuer Strahlen-und Kernphysik, Universitaet Bonn, Nussallee 14-16, D-53115 Bonn (Germany)

    2009-01-01

    We investigate radiative corrections to K{yields}3{pi} decays. In particular, we extend the non-relativistic framework developed recently to include real and virtual photons and show that, in a well-defined power counting scheme, the results reproduce corrections obtained in the relativistic calculation. Real photons are included exactly, beyond the soft-photon approximation, and we compare the result with the latter. The singularities generated by pionium near threshold are investigated, and a region is identified where standard perturbation theory in the fine structure constant {alpha} may be applied. We expect that the formulae provided allow one to extract S-wave {pi}{pi} scattering lengths from the cusp effect in these decays with high precision.

  12. VizieR Online Data Catalog: L/T transition dwarfs search with PS1 & WISE. II. (Best+, 2015)

    Science.gov (United States)

    Best, W. M. J.; Liu, M. C.; Magnier, E. A.; Deacon, N. R.; Aller, K. M.; Redstone, J.; Burgett, W. S.; Chambers, K. C.; Draper, P.; Flewelling, H.; Hodapp, K. W.; Kaiser, N.; Metcalfe, N.; Tonry, J. L.; Wainscoat, R. J.; Waters, C.

    2016-03-01

    We used the new Pan-STARRS1 Survey (PS1; Kaiser et al. 2010SPIE.7733E..0EK) detections through 2012 January cross-matched with the Wide-field Infrared Survey Explorer (WISE; Wright et al. 2010AJ....140.1868W) All-sky Release using a 3" matching radius. In Best et al. (2013ApJ...777...84B; Paper I), we presented seven initial discoveries from our search, all bright L/T transition dwarfs within 15pc. In this paper, we present the complete results of our search, including 79 total L/T transition dwarfs and 23 young or potentially young late-M and L dwarfs. The PS1 3π survey (K. C. Chambers et al. 2016AAS...22732407C) has obtained an average of ~12 epochs of imaging in five optical bands (gP1, rP1, iP1, zP1, yP1) with a 1.8-m wide-field telescope on Haleakala, Maui, covering the entire sky north of -30° declination. Imaging began in 2010 May and concluded in 2014 March. The WISE All-sky Source Catalog (Cutri et al. 2012, II/311) comprises data taken between 2010 January and August in four mid-infrared bands: W1 (3.6um), W2 (4.5um), W3 (12um), and W4 (22um). We searched the UKIDSS Data Release 9 (DR9; Lawrence et al. 2013, II/319) and VISTA Hemisphere Survey (Cross et al. 2012A&A...548A.119C) catalogs for JHK photometry of our candidates on the Mauna Kea Observatories (MKO) filter system. For objects not found in either survey, we obtained follow-up images using WFCAM on the 3.8m United Kingdom InfraRed Telescope (UKIRT) as part of the UKIRT Service Program. Observations took place on multiple nights spanning 2010 September to 2013 December. We obtained low-resolution near-IR spectra for our 142 candidates between 2012 July and 2014 January using the NASA IRTF/SpeX spectrograph (details of our observations are listed in table 3). (7 data files).

  13. Chronic Stress Contributes to Cognitive Dysfunction and Hippocampal Metabolic Abnormalities in APP/PS1 Mice

    Directory of Open Access Journals (Sweden)

    Bing Han

    2017-03-01

    Full Text Available Background/Aims: Stress response is determined by the brain, and the brain is a sensitive target for stress. Our previous experiments have confirmed that once the stress response is beyond the tolerable limit of the brain, particularly that of the hippocampus, it will have deleterious effects on hippocampal structure and function; however, the metabolic mechanisms for this are not well understood. Methods: Here, we used morris water maze, elisa and gas chromatography-time of flight/mass spectrometry to observe the changes in cognition, neuropathology and metabolomics in the hippocampus of APP/PS1 mice and wild-type (C57 mice caused by chronic unpredictable mild stress (CUMS, we also further explored the correlation between cognition and metabolomics. Results: We found that 4 weeks of CUMS aggravated cognitive impairment and increased amyloid-β deposition in APP/PS1 mice, but did not affect C57 mice. Under non-stress conditions, compared with C57 mice, there were 8 different metabolites in APP/PS1 mice. However, following CUMS, 3 different metabolites were changed compared with untreated C57 mice. Compared to APP/PS1 mice, there were 7 different metabolites in APP/PS1+CUMS mice. Among these alterations, 3-hydroxybutyric acid, valine, serine, beta-alanine and o-phosphorylethanolamine, which are involved in sphingolipid metabolism, synthesis and degradation of ketone bodies, and amino acid metabolism. Conclusion: The results indicate that APP/PS1 mice are more vulnerable to stress than C57 mice, and the metabolic mechanisms of stress-related cognitive impairment in APP/PS1 mice are related to multiple pathways and networks, including sphingolipid metabolism, synthesis and degradation of ketone bodies, and amino acid metabolism.

  14. Cusps in K{sub L}{yields}3{pi} decays

    Energy Technology Data Exchange (ETDEWEB)

    Bissegger, M. [Institute for Theoretical Physics, University of Bern, Sidlerstr. 5, CH-3012 Bern (Switzerland); Fuhrer, A. [Institute for Theoretical Physics, University of Bern, Sidlerstr. 5, CH-3012 Bern (Switzerland)], E-mail: afuhrer@itp.unibe.ch; Gasser, J. [Institute for Theoretical Physics, University of Bern, Sidlerstr. 5, CH-3012 Bern (Switzerland); Kubis, B.; Rusetsky, A. [Helmholtz-Institut fuer Strahlen- und Kernphysik, Universitaet Bonn, Nussallee 14-16, D-53115 Bonn (Germany)

    2008-01-24

    The pion mass difference generates a pronounced cusp in K{yields}3{pi} decays, the strength of which is related to the {pi}{pi} S-wave scattering lengths. We apply an effective field theory framework developed earlier to evaluate the amplitudes for K{sub L}{yields}3{pi} decays in a systematic manner, where the strictures imposed by analyticity and unitarity are respected automatically. The amplitudes for the decay {eta}{yields}3{pi} are also given.

  15. Characterization of in vivo MRI detectable thalamic amyloid plaques from APP/PS1 mice

    Energy Technology Data Exchange (ETDEWEB)

    Dhenain, M. [URA CEA CNRS 2210, I2BM, SHFJ, 4 Place du General Leclerc, 91401 Orsay Cedex (France); Dhenain, M.; El Tannir El Tayara, N.; Wu, T.D.; Volk, A.; Quintana, C. [U759 INSERM, Centre Universitaire, Laboratoire 112, 91405 Orsay Cedex (France); Dhenain, M.; El Tannir El Tayara, N.; Wu, T.D.; Volk, A.; Quintana, C. [Institut Curie, Centre Universitaire, Laboratoire 112, 91405 Orsay Cedex (France); Guegan, M.; Delatour, B. [Instituto de Microelectronica de Madrid-CSIC, 8, Isaac Newton, 28760 Tres Cantos, Madrid (Spain)

    2009-07-01

    Amyloid deposits are one of the hallmarks of Alzheimer's disease. Recent studies, in transgenic mice modeling Alzheimer's disease showed that, using in vivo, contrast agent-free, MRI, thalamic amyloid plaques are more easily detected than other plaques of the brain. Our study evaluated the characteristics of these thalamic plaques in a large population of APP/PS1, PS1 and C57BL/6 mice. Thalamic spots were detected in all mice but with different frequency and magnitude. Hence, the prevalence and size of the lesions were higher in APP/PS1 mice. However, even in APP/PS1 mice, thalamic spots did not occur in all the old animals. In APP/PS1 mice, spots detection was related to high iron and calcium load within amyloid plaques and thus reflects the ability of such plaque to capture large amounts of minerals. Interestingly, calcium and iron was also detected in extra-thalamic plaques but with a lower intensity. Hypointense lesions in the thalamus were not associated with the iron load in the tissue surrounding the plaques, nor with micro-hemorrhages, inflammation, or a neuro-degenerative context. (authors)

  16. Genomic differentiation among two strains of the PS1 clade isolated from geographically separated marine habitats

    KAUST Repository

    Jimenez Infante, Francy M.

    2014-05-22

    Using dilution-to-extinction cultivation, we isolated a strain affiliated with the PS1 clade from surface waters of the Red Sea. Strain RS24 represents the second isolate of this group of marine Alphaproteobacteria after IMCC14465 that was isolated from the East (Japan) Sea. The PS1 clade is a sister group to the OCS116 clade, together forming a putatively novel order closely related to Rhizobiales. While most genomic features and most of the genetic content are conserved between RS24 and IMCC14465, their average nucleotide identity (ANI) is < 81%, suggesting two distinct species of the PS1 clade. Next to encoding two different variants of proteorhodopsin genes, they also harbor several unique genomic islands that contain genes related to degradation of aromatic compounds in IMCC14465 and in polymer degradation in RS24, possibly reflecting the physicochemical differences in the environment they were isolated from. No clear differences in abundance of the genomic content of either strain could be found in fragment recruitment analyses using different metagenomic datasets, in which both genomes were detectable albeit as minor part of the communities. The comparative genomic analysis of both isolates of the PS1 clade and the fragment recruitment analysis provide first insights into the ecology of this group. © 2014 Federation of European Microbiological Societies.

  17. Genomic differentiation among two strains of the PS1 clade isolated from geographically separated marine habitats

    KAUST Repository

    Jimenez Infante, Francy M.; Ngugi, David; Alam, Intikhab; Rashid, Mamoon; Ba Alawi, Wail; Kamau, Allan; Bajic, Vladimir B.; Stingl, Ulrich

    2014-01-01

    Using dilution-to-extinction cultivation, we isolated a strain affiliated with the PS1 clade from surface waters of the Red Sea. Strain RS24 represents the second isolate of this group of marine Alphaproteobacteria after IMCC14465 that was isolated

  18. Lack of tau proteins rescues neuronal cell death and decreases amyloidogenic processing of APP in APP/PS1 mice.

    Science.gov (United States)

    Leroy, Karelle; Ando, Kunie; Laporte, Vincent; Dedecker, Robert; Suain, Valérie; Authelet, Michèle; Héraud, Céline; Pierrot, Nathalie; Yilmaz, Zehra; Octave, Jean-Noël; Brion, Jean-Pierre

    2012-12-01

    Lack of tau expression has been reported to protect against excitotoxicity and to prevent memory deficits in mice expressing mutant amyloid precursor protein (APP) identified in familial Alzheimer disease. In APP mice, mutant presenilin 1 (PS1) enhances generation of Aβ42 and inhibits cell survival pathways. It is unknown whether the deficient phenotype induced by concomitant expression of mutant PS1 is rescued by absence of tau. In this study, we have analyzed the effect of tau deletion in mice expressing mutant APP and PS1. Although APP/PS1/tau(+/+) mice had a reduced survival, developed spatial memory deficits at 6 months and motor impairments at 12 months, these deficits were rescued in APP/PS1/tau(-/-) mice. Neuronal loss and synaptic loss in APP/PS1/tau(+/+) mice were rescued in the APP/PS1/tau(-/-) mice. The amyloid plaque burden was decreased by roughly 50% in the cortex and the spinal cord of the APP/PS1/tau(-/-) mice. The levels of soluble and insoluble Aβ40 and Aβ42, and the Aβ42/Aβ40 ratio were reduced in APP/PS1/tau(-/-) mice. Levels of phosphorylated APP, of β-C-terminal fragments (CTFs), and of β-secretase 1 (BACE1) were also reduced, suggesting that β-secretase cleavage of APP was reduced in APP/PS1/tau(-/-) mice. Our results indicate that tau deletion had a protective effect against amyloid induced toxicity even in the presence of mutant PS1 and reduced the production of Aβ. Copyright © 2012 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

  19. Loss of GABAergic inputs in APP/PS1 mouse model of Alzheimer's disease

    Directory of Open Access Journals (Sweden)

    Tutu Oyelami

    2014-04-01

    Full Text Available Alzheimer's disease (AD is characterized by symptoms which include seizures, sleep disruption, loss of memory as well as anxiety in patients. Of particular importance is the possibility of preventing the progressive loss of neuronal projections in the disease. Transgenic mice overexpressing EOFAD mutant PS1 (L166P and mutant APP (APP KM670/671NL Swedish (APP/PS1 develop a very early and robust Amyloid pathology and display synaptic plasticity impairments and cognitive dysfunction. Here we investigated GABAergic neurotransmission, using multi-electrode array (MEA technology and pharmacological manipulation to quantify the effect of GABA Blockers on field excitatory postsynaptic potentials (fEPSP, and immunostaining of GABAergic neurons. Using MEA technology we confirm impaired LTP induction by high frequency stimulation in APPPS1 hippocampal CA1 region that was associated with reduced alteration of the pair pulse ratio after LTP induction. Synaptic dysfunction was also observed under manipulation of external Calcium concentration and input-output curve. Electrophysiological recordings from brain slice of CA1 hippocampus area, in the presence of GABAergic receptors blockers cocktails further demonstrated significant reduction in the GABAergic inputs in APP/PS1 mice. Moreover, immunostaining of GAD65 a specific marker for GABAergic neurons revealed reduction of the GABAergic inputs in CA1 area of the hippocampus. These results might be linked to increased seizure sensitivity, premature death and cognitive dysfunction in this animal model of AD. Further in depth analysis of GABAergic dysfunction in APP/PS1 mice is required and may open new perspectives for AD therapy by restoring GABAergic function.

  20. Analysis of the {omega} and {phi}{yields}3{pi} Dalitz plot

    Energy Technology Data Exchange (ETDEWEB)

    Niecknig, Franz; Schneider, Sebastian P.; Kubis, Bastian [Helmholtz-Institut fuer Strahlen- und Kernphysik (Theorie), Nussallee 14-16, D-53115 Bonn (Germany)

    2012-07-01

    The theoretical description of vector meson interactions in hadron physics remains a challenge. With the ongoing experimental interest in {omega}{yields}3{pi} and {phi}{yields}3{pi} decays the need for equally precise theoretical predictions remains. The prevailing treatments all lack a thorough inclusion of final state interactions. In this talk we introduce a dispersive approach to these decays and study how crossed-channel rescattering effects shape the Dalitz plot.

  1. Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations.

    Science.gov (United States)

    Lee, Ju-Hyun; Yu, W Haung; Kumar, Asok; Lee, Sooyeon; Mohan, Panaiyur S; Peterhoff, Corrinne M; Wolfe, Devin M; Martinez-Vicente, Marta; Massey, Ashish C; Sovak, Guy; Uchiyama, Yasuo; Westaway, David; Cuervo, Ana Maria; Nixon, Ralph A

    2010-06-25

    Macroautophagy is a lysosomal degradative pathway essential for neuron survival. Here, we show that macroautophagy requires the Alzheimer's disease (AD)-related protein presenilin-1 (PS1). In PS1 null blastocysts, neurons from mice hypomorphic for PS1 or conditionally depleted of PS1, substrate proteolysis and autophagosome clearance during macroautophagy are prevented as a result of a selective impairment of autolysosome acidification and cathepsin activation. These deficits are caused by failed PS1-dependent targeting of the v-ATPase V0a1 subunit to lysosomes. N-glycosylation of the V0a1 subunit, essential for its efficient ER-to-lysosome delivery, requires the selective binding of PS1 holoprotein to the unglycosylated subunit and the Sec61alpha/oligosaccharyltransferase complex. PS1 mutations causing early-onset AD produce a similar lysosomal/autophagy phenotype in fibroblasts from AD patients. PS1 is therefore essential for v-ATPase targeting to lysosomes, lysosome acidification, and proteolysis during autophagy. Defective lysosomal proteolysis represents a basis for pathogenic protein accumulations and neuronal cell death in AD and suggests previously unidentified therapeutic targets.

  2. Fading Skies

    Science.gov (United States)

    Sio, Betsy Menson

    2009-01-01

    A sky fading from blue to white to red at the horizon, and water darkening from light to midnight blue. Strong diagonals slashing through the image, drawing a viewer's eyes deeper into the picture, and delicate trees poised to convey a sense of beauty. These are the fascinating strengths of the ukiyo-e woodblock prints of Japanese artist Ando…

  3. Evidence for the decay $B_c^+ \\rightarrow J/\\psi 3\\pi^+ 2\\pi^-$

    CERN Document Server

    Aaij, Roel; Adinolfi, Marco; Affolder, Anthony; Ajaltouni, Ziad; Albrecht, Johannes; Alessio, Federico; Alexander, Michael; Ali, Suvayu; Alkhazov, Georgy; Alvarez Cartelle, Paula; Alves Jr, Antonio; Amato, Sandra; Amerio, Silvia; Amhis, Yasmine; An, Liupan; Anderlini, Lucio; Anderson, Jonathan; Andreassen, Rolf; Andreotti, Mirco; Andrews, Jason; Appleby, Robert; Aquines Gutierrez, Osvaldo; Archilli, Flavio; Artamonov, Alexander; Artuso, Marina; Aslanides, Elie; Auriemma, Giulio; Baalouch, Marouen; Bachmann, Sebastian; Back, John; Badalov, Alexey; Balagura, Vladislav; Baldini, Wander; Barlow, Roger; Barschel, Colin; Barsuk, Sergey; Barter, William; Batozskaya, Varvara; Bauer, Thomas; Bay, Aurelio; Beddow, John; Bedeschi, Franco; Bediaga, Ignacio; Belogurov, Sergey; Belous, Konstantin; Belyaev, Ivan; Ben-Haim, Eli; Bencivenni, Giovanni; Benson, Sean; Benton, Jack; Berezhnoy, Alexander; Bernet, Roland; Bettler, Marc-Olivier; van Beuzekom, Martinus; Bien, Alexander; Bifani, Simone; Bird, Thomas; Bizzeti, Andrea; Bjørnstad, Pål Marius; Blake, Thomas; Blanc, Frédéric; Blouw, Johan; Blusk, Steven; Bocci, Valerio; Bondar, Alexander; Bondar, Nikolay; Bonivento, Walter; Borghi, Silvia; Borgia, Alessandra; Borsato, Martino; Bowcock, Themistocles; Bowen, Espen Eie; Bozzi, Concezio; Brambach, Tobias; van den Brand, Johannes; Bressieux, Joël; Brett, David; Britsch, Markward; Britton, Thomas; Brook, Nicholas; Brown, Henry; Bursche, Albert; Busetto, Giovanni; Buytaert, Jan; Cadeddu, Sandro; Calabrese, Roberto; Callot, Olivier; Calvi, Marta; Calvo Gomez, Miriam; Camboni, Alessandro; Campana, Pierluigi; Campora Perez, Daniel; Caponio, Francesco; Carbone, Angelo; Carboni, Giovanni; Cardinale, Roberta; Cardini, Alessandro; Carranza-Mejia, Hector; Carson, Laurence; Carvalho Akiba, Kazuyoshi; Casse, Gianluigi; Cassina, Lorenzo; Castillo Garcia, Lucia; Cattaneo, Marco; Cauet, Christophe; Cenci, Riccardo; Charles, Matthew; Charpentier, Philippe; Cheung, Shu-Faye; Chiapolini, Nicola; Chrzaszcz, Marcin; Ciba, Krzystof; Cid Vidal, Xabier; Ciezarek, Gregory; Clarke, Peter; Clemencic, Marco; Cliff, Harry; Closier, Joel; Coca, Cornelia; Coco, Victor; Cogan, Julien; Cogneras, Eric; Collins, Paula; Comerma-Montells, Albert; Contu, Andrea; Cook, Andrew; Coombes, Matthew; Coquereau, Samuel; Corti, Gloria; Counts, Ian; Couturier, Benjamin; Cowan, Greig; Craik, Daniel Charles; Cruz Torres, Melissa Maria; Cunliffe, Samuel; Currie, Robert; D'Ambrosio, Carmelo; Dalseno, Jeremy; David, Pascal; David, Pieter; Davis, Adam; De Bruyn, Kristof; De Capua, Stefano; De Cian, Michel; De Miranda, Jussara; De Paula, Leandro; De Silva, Weeraddana; De Simone, Patrizia; Decamp, Daniel; Deckenhoff, Mirko; Del Buono, Luigi; Déléage, Nicolas; Derkach, Denis; Deschamps, Olivier; Dettori, Francesco; Di Canto, Angelo; Dijkstra, Hans; Donleavy, Stephanie; Dordei, Francesca; Dorigo, Mirco; Dosil Suárez, Alvaro; Dossett, David; Dovbnya, Anatoliy; Dupertuis, Frederic; Durante, Paolo; Dzhelyadin, Rustem; Dziurda, Agnieszka; Dzyuba, Alexey; Easo, Sajan; Egede, Ulrik; Egorychev, Victor; Eidelman, Semen; Eisenhardt, Stephan; Eitschberger, Ulrich; Ekelhof, Robert; Eklund, Lars; El Rifai, Ibrahim; Elsasser, Christian; Esen, Sevda; Falabella, Antonio; Färber, Christian; Farinelli, Chiara; Farley, Nathanael; Farry, Stephen; Ferguson, Dianne; Fernandez Albor, Victor; Ferreira Rodrigues, Fernando; Ferro-Luzzi, Massimiliano; Filippov, Sergey; Fiore, Marco; Fiorini, Massimiliano; Firlej, Miroslaw; Fitzpatrick, Conor; Fiutowski, Tomasz; Fontana, Marianna; Fontanelli, Flavio; Forty, Roger; Francisco, Oscar; Frank, Markus; Frei, Christoph; Frosini, Maddalena; Fu, Jinlin; Furfaro, Emiliano; Gallas Torreira, Abraham; Galli, Domenico; Gallorini, Stefano; Gambetta, Silvia; Gandelman, Miriam; Gandini, Paolo; Gao, Yuanning; Garofoli, Justin; Garra Tico, Jordi; Garrido, Lluis; Gaspar, Clara; Gauld, Rhorry; Gavardi, Laura; Gersabeck, Evelina; Gersabeck, Marco; Gershon, Timothy; Ghez, Philippe; Gianelle, Alessio; Giani', Sebastiana; Gibson, Valerie; Giubega, Lavinia-Helena; Gligorov, V.V.; Göbel, Carla; Golubkov, Dmitry; Golutvin, Andrey; Gomes, Alvaro; Gordon, Hamish; Gotti, Claudio; Grabalosa Gándara, Marc; Graciani Diaz, Ricardo; Granado Cardoso, Luis Alberto; Graugés, Eugeni; Graziani, Giacomo; Grecu, Alexandru; Greening, Edward; Gregson, Sam; Griffith, Peter; Grillo, Lucia; Grünberg, Oliver; Gui, Bin; Gushchin, Evgeny; Guz, Yury; Gys, Thierry; Hadjivasiliou, Christos; Haefeli, Guido; Haen, Christophe; Hafkenscheid, Tom; Haines, Susan; Hall, Samuel; Hamilton, Brian; Hampson, Thomas; Han, Xiaoxue; Hansmann-Menzemer, Stephanie; Harnew, Neville; Harnew, Samuel; Harrison, Jonathan; Hartmann, Thomas; He, Jibo; Head, Timothy; Heijne, Veerle; Hennessy, Karol; Henrard, Pierre; Henry, Louis; Hernando Morata, Jose Angel; van Herwijnen, Eric; Heß, Miriam; Hicheur, Adlène; Hill, Donal; Hoballah, Mostafa; Hombach, Christoph; Hulsbergen, Wouter; Hunt, Philip; Hussain, Nazim; Hutchcroft, David; Hynds, Daniel; Idzik, Marek; Ilten, Philip; Jacobsson, Richard; Jaeger, Andreas; Jans, Eddy; Jaton, Pierre; Jawahery, Abolhassan; Jezabek, Marek; Jing, Fanfan; John, Malcolm; Johnson, Daniel; Jones, Christopher; Joram, Christian; Jost, Beat; Jurik, Nathan; Kaballo, Michael; Kandybei, Sergii; Kanso, Walaa; Karacson, Matthias; Karbach, Moritz; Kelsey, Matthew; Kenyon, Ian; Ketel, Tjeerd; Khanji, Basem; Khurewathanakul, Chitsanu; Klaver, Suzanne; Kochebina, Olga; Kolpin, Michael; Komarov, Ilya; Koopman, Rose; Koppenburg, Patrick; Korolev, Mikhail; Kozlinskiy, Alexandr; Kravchuk, Leonid; Kreplin, Katharina; Kreps, Michal; Krocker, Georg; Krokovny, Pavel; Kruse, Florian; Kucharczyk, Marcin; Kudryavtsev, Vasily; Kurek, Krzysztof; Kvaratskheliya, Tengiz; La Thi, Viet Nga; Lacarrere, Daniel; Lafferty, George; Lai, Adriano; Lambert, Dean; Lambert, Robert W; Lanciotti, Elisa; Lanfranchi, Gaia; Langenbruch, Christoph; Langhans, Benedikt; Latham, Thomas; Lazzeroni, Cristina; Le Gac, Renaud; van Leerdam, Jeroen; Lees, Jean-Pierre; Lefèvre, Regis; 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Merk, Marcel; Milanes, Diego Alejandro; Minard, Marie-Noelle; Molina Rodriguez, Josue; Monteil, Stephane; Moran, Dermot; Morandin, Mauro; Morawski, Piotr; Mordà, Alessandro; Morello, Michael Joseph; Moron, Jakub; Mountain, Raymond; Muheim, Franz; Müller, Katharina; Muresan, Raluca; Muster, Bastien; Naik, Paras; Nakada, Tatsuya; Nandakumar, Raja; Nasteva, Irina; Needham, Matthew; Neri, Nicola; Neubert, Sebastian; Neufeld, Niko; Neuner, Max; Nguyen, Anh Duc; Nguyen, Thi-Dung; Nguyen-Mau, Chung; Nicol, Michelle; Niess, Valentin; Niet, Ramon; Nikitin, Nikolay; Nikodem, Thomas; Novoselov, Alexey; Oblakowska-Mucha, Agnieszka; Obraztsov, Vladimir; Oggero, Serena; Ogilvy, Stephen; Okhrimenko, Oleksandr; Oldeman, Rudolf; Onderwater, Gerco; Orlandea, Marius; Otalora Goicochea, Juan Martin; Owen, Patrick; Oyanguren, Maria Arantza; Pal, Bilas Kanti; Palano, Antimo; Palombo, Fernando; Palutan, Matteo; Panman, Jacob; Papanestis, Antonios; Pappagallo, Marco; Pappalardo, Luciano; Parkes, Christopher; 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Tolk, Siim; Tomassetti, Luca; Tonelli, Diego; Topp-Joergensen, Stig; Torr, Nicholas; Tournefier, Edwige; Tourneur, Stephane; Tran, Minh Tâm; Tresch, Marco; Tsaregorodtsev, Andrei; Tsopelas, Panagiotis; Tuning, Niels; Ubeda Garcia, Mario; Ukleja, Artur; Ustyuzhanin, Andrey; Uwer, Ulrich; Vagnoni, Vincenzo; Valenti, Giovanni; Vallier, Alexis; Vazquez Gomez, Ricardo; Vazquez Regueiro, Pablo; Vázquez Sierra, Carlos; Vecchi, Stefania; Velthuis, Jaap; Veltri, Michele; Veneziano, Giovanni; Vesterinen, Mika; Viaud, Benoit; Vieira, Daniel; Vilasis-Cardona, Xavier; Vollhardt, Achim; Volyanskyy, Dmytro; Voong, David; Vorobyev, Alexey; Vorobyev, Vitaly; Voß, Christian; Voss, Helge; de Vries, Jacco; Waldi, Roland; Wallace, Charlotte; Wallace, Ronan; Wandernoth, Sebastian; Wang, Jianchun; Ward, David; Watson, Nigel; Websdale, David; Whitehead, Mark; Wicht, Jean; Wiedner, Dirk; Wilkinson, Guy; Williams, Matthew; Williams, Mike; Wilson, Fergus; Wimberley, Jack; Wishahi, Julian; Wislicki, Wojciech; Witek, Mariusz; Wormser, Guy; Wotton, Stephen; Wright, Simon; Wu, Suzhi; Wyllie, Kenneth; Xie, Yuehong; Xing, Zhou; Yang, Zhenwei; Yuan, Xuhao; Yushchenko, Oleg; Zangoli, Maria; Zavertyaev, Mikhail; Zhang, Feng; Zhang, Liming; Zhang, Wen Chao; Zhang, Yanxi; Zhelezov, Alexey; Zhokhov, Anatoly; Zhong, Liang; Zvyagin, Alexander

    2014-01-01

    Evidence is presented for the decay $B_c+\\rightarrow J/\\psi 3\\pi^+2\\pi^-$ using proton-proton collision data, corresponding to an integrated luminosity of 3fb$^{-1}$, collected with the LHCb detector. A signal yield of $32\\pm8$ decays is found with a significance of 4.5 standard deviations. The ratio of the branching fraction of the $B_c^+\\rightarrow J/\\psi 3\\pi^+ 2\\pi^-$ decay to that of the $B_c^+ \\rightarrow J/\\psi \\pi^+$ decay is measured to be $$ \\frac{Br (B_c^+ \\rightarrow J/\\psi 3\\pi^+2\\pi^)}{Br (B_c^+ \\rightarrow J/\\psi \\pi^+)} = 1.74\\pm0.44\\pm0.24, $$ where the first uncertainty is statistical and the second is systematic.

  4. Efficient biotransformation of herbicide diuron by bacterial strain Micrococcus sp. PS-1.

    Science.gov (United States)

    Sharma, Priyanka; Chopra, Adity; Cameotra, Swaranjit Singh; Suri, C Raman

    2010-11-01

    A Gram-positive, Micrococcus sp. strain PS-1 capable of utilizing phenylurea herbicide diuron as a sole carbon source at a high concentration (up to 250 ppm) was isolated from diuron storage site by selective enrichment study. The taxonomic characterization with 16S rRNA gene sequencing (1,477 bp) identified PS-1 as a member of Micrococcus sp. It was studied for the degradation of diuron and a range of its analogues (monuron, linuron, monolinuron, chlortoluron and fenuron). The shake flasks experiments demonstrated fast degradation of diuron (up to 96% at 250 ppm within 30 h incubation) with the addition of small quantity (0.01%) of non-ionic detergent. The relative degradation profile by the isolate was in the order of fenuron > monuron > diuron > linuron > monolinuron > chlortoluron. Further, the biochemical characterization of catabolic pathway by spectroscopic and chromatographic techniques demonstrated that the degradation proceeded via formation of dealkylated metabolites to form 3,4-dichloroaniline (3,4-DCA). It was the major metabolite formed, associated with profound increase in degradation kinetics in presence of appropriate additive.

  5. AβPP/PS1 Transgenic Mice Show Sex Differences in the Cerebellum Associated with Aging.

    Science.gov (United States)

    Ordoñez-Gutierrez, Lara; Fernandez-Perez, Ivan; Herrera, Jose Luis; Anton, Marta; Benito-Cuesta, Irene; Wandosell, Francisco

    2016-09-06

    Cerebellar pathology has been related to presenilin 1 mutations in certain pedigrees of familial Alzheimer's disease. However, cerebellum tissue has not been intensively analyzed in transgenic models of mutant presenilins. Furthermore, the effect of the sex of the mice was not systematically analyzed, despite the fact that important gender differences in the evolution of the disease in the human population have been described. We analyzed whether the progression of amyloidosis in a double transgenic mouse, AβPP/PS1, is susceptible to aging and differentially affects males and females. The accumulation of amyloid in the cerebellum differentially affects males and females of the AβPP/PS1 transgenic line, which was found to be ten-fold higher in 15-month-old females. Amyloid-β accumulation was more evident in the molecular layer of the cerebellum, but glia reaction was only observed in the granular layer of the older mice. The sex divergence was also observed in other neuronal, survival, and autophagic markers. The cerebellum plays an important role in the evolution of the pathology in this transgenic mouse model. Sex differences could be crucial for a complete understanding of this disease. We propose that the human population could be studied in this way. Sex-specific treatment strategies in human populations could show a differential response to the therapeutic approach.

  6. The PS1 hairpin of Mcm3 is essential for viability and for DNA unwinding in vitro.

    Directory of Open Access Journals (Sweden)

    Simon K W Lam

    Full Text Available The pre-sensor 1 (PS1 hairpin is found in ring-shaped helicases of the AAA+ family (ATPases associated with a variety of cellular activities of proteins and is implicated in DNA translocation during DNA unwinding of archaeal mini-chromosome maintenance (MCM and superfamily 3 viral replicative helicases. To determine whether the PS1 hairpin is required for the function of the eukaryotic replicative helicase, Mcm2-7 (also comprised of AAA+ proteins, we mutated the conserved lysine residue in the putative PS1 hairpin motif in each of the Saccharomyces cerevisiae Mcm2-7 subunits to alanine. Interestingly, only the PS1 hairpin of Mcm3 was essential for viability. While mutation of the PS1 hairpin in the remaining MCM subunits resulted in minimal phenotypes, with the exception of Mcm7 which showed slow growth under all conditions examined, the viable alleles were synthetic lethal with each other. Reconstituted Mcm2-7 containing Mcm3 with the PS1 mutation (Mcm3(K499A had severely decreased helicase activity. The lack of helicase activity provides a probable explanation for the inviability of the mcm3(K499A strain. The ATPase activity of Mcm2-7(3K499A was similar to the wild type complex, but its interaction with single-stranded DNA in an electrophoretic mobility shift assay and its associations in cells were subtly altered. Together, these findings indicate that the PS1 hairpins in the Mcm2-7 subunits have important and distinct functions, most evident by the essential nature of the Mcm3 PS1 hairpin in DNA unwinding.

  7. Preliminary Astrometric Results from the PS1 Demo Month and Routine Survey Operations

    Science.gov (United States)

    2010-09-01

    with the  2MASS  catalog 3 to  produce preliminary astrometric solutions.  Using these  coordinates, the NOFS astrometric pipeline correlates PS1...objects with other catalogs (USNO‐B1.0, SDSS, Tycho‐2,  2MASS , etc.) so that unique star identification numbers can  be assigned across all catalogs. This...correlated  pair, and the standard deviation for these pairings is about  0.3 arcsec.  Whereas the  2MASS  catalog error for a brighter  star is believed to be

  8. Magnetization transfer contrast imaging detects early white matter changes in the APP/PS1 amyloidosis mouse model

    Directory of Open Access Journals (Sweden)

    Jelle Praet

    2016-01-01

    Full Text Available While no definitive cure for Alzheimer's disease exists yet, currently available treatments would benefit greatly from an earlier diagnosis. It has previously been shown that Magnetization transfer contrast (MTC imaging is able to detect amyloid β plaques in old APP/PS1 mice. In the current study we investigated if MTC is also able to visualize early amyloid β (Aβ induced pathological changes. In a cross-sectional study, a comparison was made between the MT ratio of wild type (WT and APP/PS1 mice at 2, 4, 6, 8 and 24 months of age. We observed an increased MT-ratio in the cortex of 24 month old APP/PS1 mice as compared to WT mice. However, when comparing the MT-ratio of the cortex of WT mice with the MT-ratio of the APP/PS1 mice at 2, 4, 6 or 8 months of age, no significant changes could be observed. In contrast to the cortex, we consistently observed a decreased MT-ratio in the splenium of 4, 6 and 8 month old APP/PS1 mice as compared to age-matched WT mice. Lastly, the decreased MT-ratio in the splenium of APP/PS1 mice correlated to the Aβ plaque deposition, astrogliosis and microgliosis. This MT-ratio decrease did however not correlate to the myelin content. Combined, our results suggest that MTC is able to visualize early Aβ-induced changes in the splenium but not the cortex of APP/PS1 mice.

  9. Anomalies in social behaviors and exploratory activities in an APPswe/PS1 mouse model of Alzheimer's disease.

    Science.gov (United States)

    Filali, Mohammed; Lalonde, Robert; Rivest, Serge

    2011-10-24

    Alzheimer's disease is characterized by deficits in social communication, associated with generalized apathy or agitation, as well as social memory. To assess social behaviors in 6-month-old male APPswe/PS1 bigenics relative to non-transgenic controls, the 3-chamber test was used, together with open-field and elevated plus-maze tests of exploration. APPswe/PS1 mice were less willing to engage in social interaction than wild-type, avoiding an unfamiliar stimulus mouse, probably not due to generalized apathy because in both tests of exploratory activity the mutants were hyperactive. This study reveals reduced "sociability" combined with hyperactivity in an APPswe/PS1 mouse model of Alzheimer dementia. Copyright © 2011 Elsevier Inc. All rights reserved.

  10. The Presenilin-1 ΔE9 Mutation Results in Reduced γ-Secretase Activity, but Not Total Loss of PS1 Function, in Isogenic Human Stem Cells

    Directory of Open Access Journals (Sweden)

    Grace Woodruff

    2013-11-01

    Full Text Available Presenilin 1 (PS1 is the catalytic core of γ-secretase, which cleaves type 1 transmembrane proteins, including the amyloid precursor protein (APP. PS1 also has γ-secretase-independent functions, and dominant PS1 missense mutations are the most common cause of familial Alzheimer’s disease (FAD. Whether PS1 FAD mutations are gain- or loss-of-function remains controversial, primarily because most studies have relied on overexpression in mouse and/or nonneuronal systems. We used isogenic euploid human induced pluripotent stem cell lines to generate and study an allelic series of PS1 mutations, including heterozygous null mutations and homozygous and heterozygous FAD PS1 mutations. Rigorous analysis of this allelic series in differentiated, purified neurons allowed us to resolve this controversy and to conclude that FAD PS1 mutations, expressed at normal levels in the appropriate cell type, impair γ-secretase activity but do not disrupt γ-secretase-independent functions of PS1. Thus, FAD PS1 mutations do not act as simple loss of PS1 function but instead dominantly gain an activity toxic to some, but not all, PS1 functions.

  11. Cholinergic degeneration is associated with increased plaque deposition and cognitive impairment in APPswe/PS1dE9 mice

    DEFF Research Database (Denmark)

    Laursen, Bettina; Mørk, Arne; Plath, Niels

    2013-01-01

    mice was not due to a more extensive cholinergic degeneration since the reduction in choline acetyltransferase activity was similar following SAP treatment in APP/PS1 mice and Wt. Interestingly, plaque load was significantly increased in SAP treated APP/PS1 mice relative to sham lesioned APP/PS1 mice....... Additionally, APP/PS1 mice treated with SAP showed a tendency towards an increased level of soluble and insoluble Aß1-40 and Aß1-42 measured in brain tissue homogenate. Our results suggest that the combination of cholinergic degeneration and Aß overexpression in the APP/PS1 mouse model results in cognitive...... decline and accelerated plaque burden. SAP treated APP/PS1 mice might thus constitute an improved model of Alzheimer's disease-like neuropathology and cognitive deficits compared to the conventional APP/PS1 model without selective removal of basal forebrain cholinergic neurons....

  12. Acute exercise does not modify brain activity and memory performance in APP/PS1 mice.

    Directory of Open Access Journals (Sweden)

    Angelica Miki Stein

    Full Text Available Age is the main risk factor for Alzheimer´s disease (AD. With an increasingly aging population, development of affordable screening techniques to determine cognitive status will help identify population-at-risk for further follow-up. Because physical exercise is known to modulate cognitive performance, we used it as a functional test of cognitive health. Mice were submitted to treadmill running at moderate speed for 30 min, and their brain activity was monitored before and after exercise using electrocorticogram (ECG recordings. After exercise, normal, but not APP/PS1 mice, a well established AD model, showed significantly increased ECG theta rhythm. At the same time normal, but not AD mice, showed significantly enhanced performance in a spatial memory test after exercise. Therefore, we postulate that a running bout coupled to pre- and post-exercise brain activity recordings will help identify individuals with cognitive alterations, by determining the presence or absence of exercise-specific changes in brain activity. Work in humans using a bout of moderate exercise plus electroencephalography, a clinically affordable procedure, is warranted.

  13. Acute exercise does not modify brain activity and memory performance in APP/PS1 mice.

    Science.gov (United States)

    Miki Stein, Angelica; Munive, Victor; Fernandez, Ana M; Nuñez, Angel; Torres Aleman, Ignacio

    2017-01-01

    Age is the main risk factor for Alzheimer´s disease (AD). With an increasingly aging population, development of affordable screening techniques to determine cognitive status will help identify population-at-risk for further follow-up. Because physical exercise is known to modulate cognitive performance, we used it as a functional test of cognitive health. Mice were submitted to treadmill running at moderate speed for 30 min, and their brain activity was monitored before and after exercise using electrocorticogram (ECG) recordings. After exercise, normal, but not APP/PS1 mice, a well established AD model, showed significantly increased ECG theta rhythm. At the same time normal, but not AD mice, showed significantly enhanced performance in a spatial memory test after exercise. Therefore, we postulate that a running bout coupled to pre- and post-exercise brain activity recordings will help identify individuals with cognitive alterations, by determining the presence or absence of exercise-specific changes in brain activity. Work in humans using a bout of moderate exercise plus electroencephalography, a clinically affordable procedure, is warranted.

  14. Genotype-induced changes in biophysical properties of frontal cortex lipid raft from APP/PS1 transgenic mice

    Directory of Open Access Journals (Sweden)

    Mario L Diaz

    2012-11-01

    Full Text Available Alterations in the lipid composition of lipid rafts have been demonstrated both in human brain and transgenic mouse models, and it has been postulated that aberrant lipid composition in lipid rafts is partly responsible for neuronal degeneration. In order to assess the impact of lipid changes on lipid raft functional properties, we have aimed at determining relevant physicochemical modifications in lipid rafts purified from frontal cortex of wild type (WT and APP/PS1 double transgenic mice. By means of steady-state fluorescence anisotropy analyses using two lipid soluble fluorescent probes, TMA-DPH (1-[(4-trimethyl-aminophenyl]-6-phenyl-1,3,5-hexatriene and DPH (1,6-diphenyl-1,3,5-hexatriene, we demonstrate that cortical lipid rafts from WT and APP/PS1 animals exhibit different biophysical behaviours, depending on genotype but also on age. Thus, aged APP/PS1 animals exhibited slightly more liquid-ordered lipid rafts than WT counterparts. Membrane microviscosity napp analyses demonstrate that WT lipid rafts are more fluid than APP/PS1 animals of similar age, both at the aqueous interface and hydrophobic core of the membrane. napp in APP/PS1 animals was higher for DPH than for TMA-DPH under similar experimental conditions, indicating that the internal core of the membrane is more viscous than the raft membrane at the aqueous interface. The most dramatic changes in biophysical properties of lipid rafts were observed when membrane cholesterol was depleted with methyl-beta-cyclodextrin. Overall, our results indicate that APP/PS1 genotype strongly affects physicochemical properties of lipid raft. Such alterations appear not to be homogeneous across the raft membrane axis, but rather are more prominent at the membrane plane. These changes correlate with aberrant proportions of sphingomyelin, cholesterol and saturated fatty acids, as well as polyunsaturated fatty acids, measured in lipid rafts from frontal cortex in this familial model of

  15. Effects of (-)Epicatechin on the Pathology of APP/PS1 Transgenic Mice.

    Science.gov (United States)

    Zeng, Yue-Qin; Wang, Yan-Jiang; Zhou, Xin-Fu

    2014-01-01

    Alzheimer's disease (AD) is a multifactorial disorder characterized by the progressive deterioration of neuronal networks. The clearance of Aβ from the brain and anti-inflammation are potential important strategies to prevent and treat disease. In a previous study, we demonstrated the grape seed extract (GSE) could reduce brain Aβ burden and microglia activation, but which polyphenol plays a major role in these events is not known. Here, we tested pharmacological effects of (-)epicatechin, one principle polyphenol compound in GSE, on transgenic AD mice. APP/PS1 transgenic mice were fed with (-)epicatechin diet (40 mg/kg/day) and curcumin diet (47 mg/kg/day) at 3 months of age for 9 months, the function of liver, Aβ levels in the brain and serum, AD-type neuropathology, plasma levels of inflammatory cytokines were measured. Toward the end of the experiment, we found long-term feeding of (-)epicatechin diet was well tolerated without fatality, changes in food consumption, body weight, or liver function. (-)Epicatechin significantly reduced total Aβ in brain and serum by 39 and 40%, respectively, compared with control diet. Microgliosis and astrocytosis in the brain of Alzheimer's mice were also reduced by 38 and 35%, respectively. The (-)epicatechin diet did not alter learning and memory behaviors in AD mice. This study has provided evidence on the beneficial role of (-)epicatechin in ameliorating amyloid-induced AD-like pathology in AD mice, but the impact of (-)epicatechin on tau pathology is not clear, also the mechanism needs further research.

  16. Effects of (-epicatechin on the pathology of APP/PS1 transgenic mice

    Directory of Open Access Journals (Sweden)

    Yueqin eZeng

    2014-05-01

    Full Text Available Background: Alzheimer’s disease is a multifactorial disorder characterized by the progressive deterioration of neuronal networks. The clearance of Aβ from the brain and anti-inflammation are potential important strategies to prevent and treat disease. In a previous study, we demonstrated the grape seed extract (GSE could reduce brain Aβ burden and microglia activation,but which polyphenol plays a major role in these events is not known. Here we tested pharmacological effects of (-epicatechin, one principle polyphenol compound in GSE, on transgenic AD mice.Methods: APP/PS1 transgenic mice were fed with (-epicatechin diet(40mg/kg/d and curcumin diet (47mg/kg/d at 3 months of age for 9 months, the function of liver, Aβ levels in the brain and serum, AD-type neuropathology, plasma levels of inflammatory cytokines were measured.Results: Towards the end of the experiment we found long-term feeding of (- epicatechin diet was well tolerated without fatality, changes in food consumption, body weight or liver function. (-Epicatechin significantly reduced total Aβ in brain and serum by 39% and 40%, respectively, compared with control diet. Microgliosis and astrocytosis in the brain of Alzheimer’s mice were also reduced by 38% and 35%, respectively. The (-epicatechin diet did not alter learning and memory behaviors in AD mice.Conclusions: This study has provided evidence on the beneficial role of (-epicatechin in ameliorating amyloid-induced AD-like pathology in AD mice, but the impact of (-epicatechin on tau pathology is not clear, also the mechanism needs further research.

  17. Chronic cannabidiol treatment improves social and object recognition in double transgenic APPswe/PS1∆E9 mice.

    Science.gov (United States)

    Cheng, David; Low, Jac Kee; Logge, Warren; Garner, Brett; Karl, Tim

    2014-08-01

    Patients suffering from Alzheimer's disease (AD) exhibit a decline in cognitive abilities including an inability to recognise familiar faces. Hallmark pathological changes in AD include the aggregation of amyloid-β (Aβ), tau protein hyperphosphorylation as well as pronounced neurodegeneration, neuroinflammation, neurotoxicity and oxidative damage. The non-psychoactive phytocannabinoid cannabidiol (CBD) exerts neuroprotective, anti-oxidant and anti-inflammatory effects and promotes neurogenesis. CBD also reverses Aβ-induced spatial memory deficits in rodents. Thus we determined the therapeutic-like effects of chronic CBD treatment (20 mg/kg, daily intraperitoneal injections for 3 weeks) on the APPswe/PS1∆E9 (APPxPS1) transgenic mouse model for AD in a number of cognitive tests, including the social preference test, the novel object recognition task and the fear conditioning paradigm. We also analysed the impact of CBD on anxiety behaviours in the elevated plus maze. Vehicle-treated APPxPS1 mice demonstrated impairments in social recognition and novel object recognition compared to wild type-like mice. Chronic CBD treatment reversed these cognitive deficits in APPxPS1 mice without affecting anxiety-related behaviours. This is the first study to investigate the effect of chronic CBD treatment on cognition in an AD transgenic mouse model. Our findings suggest that CBD may have therapeutic potential for specific cognitive impairments associated with AD.

  18. Photo-fermentational hydrogen production of Rhodobacter sp. KKU-PS1 isolated from an UASB reactor

    Directory of Open Access Journals (Sweden)

    Thitirut Assawamongkholsiri

    2015-05-01

    Conclusions: KKU-PS1 can produce hydrogen from at least 8 types of organic acids. By optimizing pH and temperature, a maximal hydrogen production by this strain was obtained. Additionally, by optimizing the light intensity, Rm was increased by approximately two fold and the lag phase of hydrogen production was shortened.

  19. Sky Mystery

    Science.gov (United States)

    Rubincam, David P.

    2017-01-01

    I saw something extraordinary on Wednesday, 25 September 2013, at about 10:10AM local time, while in a parking lot at the NASA Goddard Space Flight Center in Greenbelt, Maryland USA (located in the suburbs of Washington, D.C., about 20 km northeast of the White House). I looked northeast at about a 45 degree angle at a cirrus cloud. The cloud was elongated horizontally from my perspective. T o my surprise I saw a band of ripples rapidly pass from right to left along the axis of the cloud. The ripples appeared dark, like a bar code, with the bars being almost vertical (see Figure 1). There appeared to be approximately 10 bars in the band. Each bar was a few degrees in length. I estimate that each bar was about 1/10 to 1/4 degree in width and the white spaces between them about the same width. I guessed that the angular speed of the band passing along the cloud was about 1/2 to 1 degree per second. A half-moon was in another part of the sky; looking at the Moon later helped me make the estimates. After a few seconds at most the band disappeared. Then a second band repeated the performance. I kept watching to see if this was going to be a periodic phenomenon, but no further bands appeared; just the two. Of course there may have been other bands passing across the cloud before I started looking. About 30 seconds to a minute after the bands disappeared, a low-flying jetliner on the usual northeast to southwest route passed almost exactly through the spot where I had seen the bands. I estimate the jetliner was a bit bigger than the full moon. My first thought was that maybe there was something wrong inside my eyes. But looking at other clouds revealed no bands. So what caused the bands? They do not seem to have been due to the exhausts on top of the nearby building, with the cloud acting as a backdrop: one would expect a continuous, disorganized shimmering instead of two separate organized bands. Moreover, there would be no reason for bands to stop unless the exhausts

  20. PS1-10bzj: A FAST, HYDROGEN-POOR SUPERLUMINOUS SUPERNOVA IN A METAL-POOR HOST GALAXY

    Energy Technology Data Exchange (ETDEWEB)

    Lunnan, R.; Chornock, R.; Berger, E.; Milisavljevic, D.; Drout, M.; Sanders, N. E.; Challis, P. M.; Czekala, I.; Foley, R. J.; Fong, W.; Kirshner, R. P.; Leibler, C.; Marion, G. H.; Narayan, G. [Harvard-Smithsonian Center for Astrophysics, 60 Garden St., Cambridge, MA 02138 (United States); Huber, M. E. [Institute for Astronomy, University of Hawaii, 2680 Woodlawn Drive, Honolulu, HI 96822 (United States); McCrum, M.; Smartt, S. J. [Astrophysics Research Centre, School of Mathematics and Physics, Queen' s University Belfast, Belfast BT7 1NN (United Kingdom); Rest, A. [Space Telescope Science Institute, 3700 San Martin Dr., Baltimore, MD 21218 (United States); Roth, K. C. [Gemini Observatory, 670 N. Aohoku Place, Hilo, HI 96720 (United States); Scolnic, D., E-mail: rlunnan@cfa.harvard.edu [Department of Physics and Astronomy, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218 (United States); and others

    2013-07-10

    We present observations and analysis of PS1-10bzj, a superluminous supernova (SLSN) discovered in the Pan-STARRS Medium Deep Survey at a redshift z = 0.650. Spectroscopically, PS1-10bzj is similar to the hydrogen-poor SLSNe 2005ap and SCP 06F6, though with a steeper rise and lower peak luminosity (M{sub bol} {approx_equal} -21.4 mag) than previous events. We construct a bolometric light curve, and show that while PS1-10bzj's energetics were less extreme than previous events, its luminosity still cannot be explained by radioactive nickel decay alone. We explore both a magnetar spin-down and circumstellar interaction scenario and find that either can fit the data. PS1-10bzj is located in the Extended Chandra Deep Field South and the host galaxy is imaged in a number of surveys, including with the Hubble Space Telescope. The host is a compact dwarf galaxy (M{sub B} Almost-Equal-To -18 mag, diameter {approx}< 800 pc), with a low stellar mass (M{sub *} Almost-Equal-To 2.4 Multiplication-Sign 10{sup 7} M{sub Sun }), young stellar population ({tau}{sub *} Almost-Equal-To 5 Myr), and a star formation rate of {approx}2-3 M{sub Sun} yr{sup -1}. The specific star formation rate is the highest seen in an SLSN host so far ({approx}100 Gyr{sup -1}). We detect the [O III] {lambda}4363 line, and find a low metallicity: 12 + (O/H) = 7.8 {+-} 0.2 ({approx_equal} 0.1 Z{sub Sun }). Together, this indicates that at least some of the progenitors of SLSNe come from young, low-metallicity populations.

  1. KEGS Discovery of 9 Supernova Candidates in the K2 Campaign 17 field with Pan-STARRS PS1

    Science.gov (United States)

    Smith, K. W.; Rest, A.; Tucker, B. E.; Garnavich, P. M.; Margheim, S.; Kasen, D.; Olling, R.; Shaya, E.; Narayan, G.; Villar, A.; Forster, F.; Mushotzky, R.; Zenteno, A.; James, D.; Smith, R. Chris; Dotson, J. L.; Barentsen, G.; Gully-Santiago, M.; Smartt, S. J.; Wright, D. E.; Huber, M.; Chambers, K. C.; Flewelling, H.; Willman, M.; Schultz, A.; Magnier, E.; Waters, C.; Bulger, J.; Wainscoat, R. J.

    2018-05-01

    We report the following transients discovered by Pan-STARRS1 during a targeted search of the Kepler Campaign 17 field as part of the K2 Extragalactic Survey (KEGS) for Transients (see http://www.mso.anu.edu.au/kegs/ ) Information on the Pan-STARRS Survey for Transients is available at http://star.pst.qub.ac.uk/ps1threepi/ (see Huber et al. ATel #7153).

  2. VizieR Online Data Catalog: Gaia-PS1-SDSS (GPS1) proper motion catalog (Tian+, 2017)

    Science.gov (United States)

    Tian, H.-J.; Gupta, P.; Sesar, B.; Rix, H.-W.; Martin, N. F.; Liu, C.; Goldman, B.; Platais, I.; Kudritzki, R.-P.; Waters, C. Z.

    2018-02-01

    In order to construct proper motions, we analyze and model catalog positions from four different imaging surveys, as discussed below. Gaia DR1 is based on observations collected between 2014 July 25 and 2015 September 16. PS1 observations were collected between 2010 and 2014. The SDSS DR9 data used here were obtained in the years between 2000 and 2008. The images from 2MASS were taken between 1997 and 2001. (1 data file).

  3. Cytokine-producing microglia have an altered beta-amyloid load in aged APP/PS1 Tg mice

    DEFF Research Database (Denmark)

    Babcock, Alicia A; Ilkjær, Laura; Clausen, Bettina H

    2015-01-01

    of CD11b, TNF, and IL-1Ra. Cytokine production and Aβ load were assessed in neocortical CD11b(+)(CD45(+)) microglia by flow cytometry. Whereas most microglia in aged mice produced IL-1Ra, relatively low proportions of microglia produced TNF, IL-1α, and IL-1β. However, microglial production......, however the inter-relationship between these processes is poorly understood. Here we show that % Aβ plaque load followed a sigmoidal trajectory with age in the neocortex of APPswe/PS1ΔE9 Tg mice, and correlated positively with soluble Aβ40 and Aβ42. Aβ measures were moderately correlated with mRNA levels...... of these latter cytokines was generally increased in APP/PS1 Tg mice. Microglia that phagocytosed endogenously-produced Aβ were only observed in APP/PS1 Tg mice. Differences in phagocytic index and total Aβ load were observed in microglia with specific cytokine profiles. Both phagocytic index and total Aβ load...

  4. Taurine in drinking water recovers learning and memory in the adult APP/PS1 mouse model of Alzheimer's disease

    Science.gov (United States)

    Kim, Hye Yun; Kim, Hyunjin V.; Yoon, Jin H.; Kang, Bo Ram; Cho, Soo Min; Lee, Sejin; Kim, Ji Yoon; Kim, Joo Won; Cho, Yakdol; Woo, Jiwan; Kim, YoungSoo

    2014-01-01

    Alzheimer's disease (AD) is a lethal progressive neurological disorder affecting the memory. Recently, US Food and Drug Administration mitigated the standard for drug approval, allowing symptomatic drugs that only improve cognitive deficits to be allowed to accelerate on to clinical trials. Our study focuses on taurine, an endogenous amino acid found in high concentrations in humans. It has demonstrated neuroprotective properties against many forms of dementia. In this study, we assessed cognitively enhancing property of taurine in transgenic mouse model of AD. We orally administered taurine via drinking water to adult APP/PS1 transgenic mouse model for 6 weeks. Taurine treatment rescued cognitive deficits in APP/PS1 mice up to the age-matching wild-type mice in Y-maze and passive avoidance tests without modifying the behaviours of cognitively normal mice. In the cortex of APP/PS1 mice, taurine slightly decreased insoluble fraction of Aβ. While the exact mechanism of taurine in AD has not yet been ascertained, our results suggest that taurine can aid cognitive impairment and may inhibit Aβ-related damages. PMID:25502280

  5. Dark Sky Education | CTIO

    Science.gov (United States)

    Calendar Activities NOAO-S EPO Programs CADIAS Astro Chile Hugo E. Schwarz Telescope Dark Sky Education ‹› You are here CTIO Home » Outreach » NOAO-S EPO Programs » Dark Sky Education Dark Sky Education Dark Sky Education (in progress) Is an EPO Program. It runs Globe at Night, an annual program to

  6. Transplantation of NSC-derived cholinergic neuron-like cells improves cognitive function in APP/PS1 transgenic mice.

    Science.gov (United States)

    Gu, G; Zhang, W; Li, M; Ni, J; Wang, P

    2015-04-16

    The ability to selectively control the differentiation of neural stem cells (NSCs) into cholinergic neurons in vivo would be an important step toward cell replacement therapy. First, green fluorescent protein (GFP)-NSCs were induced to differentiate into cholinergic neuron-like cells (CNLs) with retinoic acid (RA) pre-induction followed by nerve growth factor (NGF) induction. Then, these CNLs were transplanted into bilateral hippocampus of APP/PS1 transgenic mice. Behavioral parameters showed by Morris water maze (MWM) tests and the percentages of GFP-labeled cholinergic neurons of CNL transplanted mice were compared with those of controls. Brain levels of choline acetyltransferase (ChAT) mRNA and proteins were analyzed by quantitative real-time PCR and Western blotting, ChAT activity and acetylcholine (ACh) concentration were also evaluated by ChAT activity and ACh concentration assay kits. Immunofluorescence analysis showed that 80.3±1.5% NSCs differentiated into CNLs after RA pre-induction followed by NGF induction in vitro. Three months after transplantation, 82.4±6.3% CNLs differentiated into cholinergic neurons in vivo. APP/PS1 mice transplanted with CNLs showed a significant improvement in learning and memory ability compared with control groups at different time points. Furthermore, CNLs transplantation dramatically increased in the expressions of ChAT mRNA and protein, as well ChAT activity and ACh concentration in APP/PS1 mice. Our findings support the prospect of using NSC-derived CNLs in developing therapies for Alzheimer's disease (AD). Copyright © 2015 IBRO. Published by Elsevier Ltd. All rights reserved.

  7. Lifetime and quenching of CO /a super 3 pi/ produced by recombination of CO2 ions in a helium afterglow.

    Science.gov (United States)

    Wauchop, T. S.; Broida, H. P.

    1972-01-01

    Demonstration that rapid dissociative recombination of CO2(+) in a flowing, helium afterglow is an efficient source of CO in the a super 3 pi metastable state. Ions produced by mixing CO2 with He(2 super 3 S) recombine to produce a CO metastable afterglow with a number density as great as 10 to the 9th per sq cm. Monitoring of the (a super 3 pi-X super 1 sigma) Cameron transition in CO was used to study the lifetime and quenching of CO (a super 3 pi) by CO2, N2, NO, and He. Recombination of CO2(+) also produces CO in the d super 3 delta and a' super 3 sigma states.

  8. An integrated proteomics approach shows synaptic plasticity changes in an APP/PS1 Alzheimer's mouse model

    DEFF Research Database (Denmark)

    Kempf, Stefan J; Metaxas, Athanasios; Ibáñez-Vea, María

    2016-01-01

    -linked glycosylation patterns, pathway-focused transcriptome and neurological disease-associated miRNAome with age-matched controls in neocortex, hippocampus, olfactory bulb and brainstem. We report that signalling pathways related to synaptic functions associated with dendritic spine morphology, neurite outgrowth......, long-term potentiation, CREB signalling and cytoskeletal dynamics were altered in 12 month old APPswe/PS1ΔE9 mice, particularly in the neocortex and olfactory bulb. This was associated with cerebral amyloidosis as well as formation of argyrophilic tangle-like structures and microglial clustering in all...

  9. Mutations in AtPS1 (Arabidopsis thaliana parallel spindle 1 lead to the production of diploid pollen grains.

    Directory of Open Access Journals (Sweden)

    Isabelle d'Erfurth

    2008-11-01

    Full Text Available Polyploidy has had a considerable impact on the evolution of many eukaryotes, especially angiosperms. Indeed, most--if not all-angiosperms have experienced at least one round of polyploidy during the course of their evolution, and many important crop plants are current polyploids. The occurrence of 2n gametes (diplogametes in diploid populations is widely recognised as the major source of polyploid formation. However, limited information is available on the genetic control of diplogamete production. Here, we describe the isolation and characterisation of the first gene, AtPS1 (Arabidopsis thaliana Parallel Spindle 1, implicated in the formation of a high frequency of diplogametes in plants. Atps1 mutants produce diploid male spores, diploid pollen grains, and spontaneous triploid plants in the next generation. Female meiosis is not affected in the mutant. We demonstrated that abnormal spindle orientation at male meiosis II leads to diplogamete formation. Most of the parent's heterozygosity is therefore conserved in the Atps1 diploid gametes, which is a key issue for plant breeding. The AtPS1 protein is conserved throughout the plant kingdom and carries domains suggestive of a regulatory function. The isolation of a gene involved in diplogamete production opens the way for new strategies in plant breeding programmes and progress in evolutionary studies.

  10. APP substitutions V715F and L720P alter PS1 conformation and differentially affect Abeta and AICD generation.

    Science.gov (United States)

    Tesco, Giuseppina; Ginestroni, Andrea; Hiltunen, Mikko; Kim, Minji; Dolios, Georgia; Hyman, Bradley T; Wang, Rong; Berezovska, Oksana; Tanzi, Rudolph E

    2005-10-01

    The 37-43 amino acid Abeta peptide is the principal component of beta-amyloid deposits in Alzheimer's disease (AD) brain, and is derived by serial proteolysis of the amyloid precursor protein (APP) by beta- and gamma-secretase. gamma-Secretase also cleaves APP at Val50 in the Abeta numbering (epsilon cleavage), resulting in the release of a fragment called APP intracellular domain (AICD). The aim of this study was to determine whether amino acid substitutions in the APP transmembrane domain differentially affect Abeta and AICD generation. We found that the APPV715F substitution, which has been previously shown to dramatically decrease Abeta40 and Abeta42 while increasing Abeta38 levels, does not affect in vitro generation of AICD. Furthermore, we found that the APPL720P substitution, which has been previously shown to prevent in vitro generation of AICD, completely prevents Abeta generation. Using a fluorescence resonance energy transfer (FRET) method, we next found that both the APPV715F and APPL720P substitutions significantly increase the distance between the N- and C-terminus of presenilin 1 (PS1), which has been proposed to contain the catalytic site of gamma-secretase. In conclusion, both APPV715F and APPL720P change PS1 conformation with differential effects on Abeta and AICD production.

  11. Observation of B+ -> J/psi 3 pi(+)2 pi(-) and B+ -> psi (2S)pi(+)pi(+)pi(-) decays

    NARCIS (Netherlands)

    Aaij, R.; Adeva, B.; Adinolfi, M.; Ajaltouni, Z.; Akar, S.; Albrecht, J.; Alessio, F.; Alexander, M. H.; Ali, S.; Alkhazov, G.; Cartelle, P. Alvarez; Alves, A. A. Jr; Amato, S.; Amerio, S.; Amhis, Y.; BEACH, LA; Anderlini, L.; Andreassi, G.; Andreotti, M.; Andrews, J.E.; Appleby, R.B.; Archilli, F.; d'Argent, P.; Romeu, J. Arnau; Artamonov, AY; Artuso, M.; Aslanides, E.; Auriemma, G.; Baalouch, M.; Babuschkin, I.; Bachmann, S; Back, Jaap Willem; Badalov, A.; Baesso, C.; Baker, S; Baldini, W.; Barlow, R.J.; Barschel, C.; Barsuk, S.; Barter, W.; Baszczyk, M.; Batozskaya, V.; Batsukh, B.; Battista, V.; Bay, A.; Beaucourt, L.; Beddow, J.; Bedeschi, F.; Bediaga, I.; Bel, L. J.; Bellee, V.; Belloli, N.; Belous, K.; Belyaev, I.; Ben-Haim, E.; Bencivenni, G.; Benson, S; Benton, J.; Berezhnoy, A.; Bernet, R.; Bertolin, A.; Castano-Betancourt, Martha; Betti, F.; Bettler, M.O.; van Beuzekom, MG; Bezshyiko, Ia; Bifani, S.; Billoir, P.; Bird, T.; Birnkraut, A.; Bitadze, A.; Bizzeti, A.; Blake, T.; Blanc, F.; Blouw, J.; Blusk, S.; Bocci, V.; Boettcher, Thomas; Bondar, A.; Bondar, N.; Bonivento, W.; Bordyuzhin, I.; Borgheresi, A.; Borghi, S.; Borisyak, M.; Borsato, M.; Bossu, F.; Boubdir, M.; Bowcock, T. J. V.; Bowen, D.E.; Bozzi, C.; Braun, S.; Britsch, M.; Britton, T.; Brodzicka, J.; Buchanan, E.; Burr, C.; Bursche, A.; Buytaert, R. J.; Cadeddu, S.; Calabrese, J. R.; Calvi, M.; Gomez, M. Calvo; Camboni, A.; Campana, P.; Perez, D. H. Campora; Capriotti, L.; Carbone, A.; Carboni, G.; Cardinale, R.; Cardini, A.; Carniti, P.; Carson, L.; Akiba, K. Carvalho; Casse, G.; Cassina, L.; Garcia, L. Castillo; Cattaneo, M.; Cauet, Ch.; Cavallero, G.; Cenci, R.; Charles, M; Charpentier, Ph.; Chatzikonstantinidis, G.; Chefdeville, M.; Chen, S.; Cheung, T.F.S.; Chobanova, V.; Chrzaszcz, M.; Vidal, X. Cid; Ciezarek, G.; Clarke, P. E. L.; Clemencic, M.; Cliff, H. V.; Closier, J.; Coco, V.; Cogan, J.; Cogneras, E.; Cogoni, V.; Cojocariu, L.; Collazuol, G.; Collins, P.; Comerma-Montells, A.; Contu, A.; COOK, AM; Coombs, Geoffrey W.; Coquereau, S.; Corti, G.; Corvo, M.; Sobral, C. M. Costa; Couturier, B.; Cowan, G. A.; Craik, D. C.; Crocombe, A. C.; Torres, M. Cruz; Cunliffe, S.; Currie, R.; D'Ambrosio, C.; Marinho, F. Da Cunha; Dall'Occo, E.; Dalseno, J.; David, P. N. Y.; Davis, A.; Francisco, O. De Aguiar; De Bruyn, K.; De Capua, S.; De Cian, M.; Miranda, J. M.; De Paula, L.; De Serio, M.; De Simone, Paolo; Dean, C. -T.; Decamp, D.; Deckenhoff, M.; Del Buono, L.; Demmer, M.; Dendek, A.; Derkach, D.; Deschamps, O.; Dettori, F.; Dey, B.; Di Canto, A.; Dijkstra, H.; Dordei, F.; Dorigo, M.; Suarez, A. Dosil; Dovbnya, A.; Dreimanis, K.; Dufour, L.; Dujany, G.; Dungs, K.; Durante, P.; Dzhelyadin, R.; Dziurda, A.; Dzyuba, A.; Deleage, N.; Easo, S.; Ebert, Martin A.; Egede, U.; Egorychev, V.; Eidelman, S.; Eisenhardt, S.; Eitschberger, U.; Ekelhof, R.; Eklund, L.; Ely, SIdi Ould; Esen, S.; Evans, Helen M.; Evans, T.; Falabella, A.; Farley, N.; Farry, S.; Fay, R. F.; Fazzini, D.; FERGUSON, D; Prieto, A. Fernandez; Ferrari, F; Rodrigues, F. Ferreira; Ferro-Luzzi, M.; Filippov, S.; Fini, R. A.; Fiore, M; Fiorini, M.; Firlej, M.; Fitzpatrick, C.; Fiutowski, T.; Fleuret, F.; Fohl, K; Fontana, M.; Fontanelli, F.; Forshaw, D. C.; Forty, R.; Lima, V. Franco; Frank, M.; Frei, C.; Fu, J.; Furfaro, E.; Farber, CR; Torreira, A. Gallas; Galli, D.; Gallorini, S.; Gambetta, S.; Gandelman, M.; Gandini, P.; Gao, Y.; Martin, L. M. Garcia; Pardinas, J. Garcia; Tico, J. Garra; Garrido, L.; Garsed, P. J.; Gascon, D.; Gaspar, C; Gavardi, L.; Gazzoni, G.; Gerick, D.; Gersabeck, E. G; Gersabeck, M.; Gershon, T.; Ghez, Ph.; Giani', S.; Gibson, V.; Girard, O. G.; Giubega, L.; Gizdov, K.; Gligorov, V. V.; Golubkov, D.; Golutvin, A.; Gomes, A.; Gorelov, I. V.; Gotti, C.; Govorkova, E.; Gandara, M. Grabalosa; Diaz, R. Graciani; Cardoso, L. A. Granado; Grauges, E.; Graverini, E.; Graziani, G.; Grecu, A.; Griffith, P.; Grillo, L.; Cazon, B. R. Gruberg; Grunberg, O.; Gushchin, EM; Guz, Yu.; Gys, T.; Gobel, C.; Hadavizadeh, T.; Hadjivasiliou, C.; Haefeli, G.; Haen, C.; Haines, S. C.; Hall, S.; Hamilton, D.B.; Han, Xiaoyan; Hansmann-Menzemer, S.; Harnew, N.; Harnew, S. T.; Harrison, Christine J.; Hatch, M.; He, J. J.; Head, T.; Heister, J. A.; Hennessy, K.; Henrard, P.; Henry, Lee; Morata, J. A. Hernando; Van Herwijnen, E.; Hess, M.; Hicheur, A.; HILL, D; Hombach, C.; Hopchev, H.; Hulsbergen, W.; Humair, T.; Hushchyn, M.; Hussain, Sabah N. A.; Hutchcroft, D.; Idzik, M.; Ilten, P.; Jacobsson, R.; Jaeger, A.; Jalocha, J.; Jans, E.; Jawahery, A.; Jiang, Fuman; John, Jestinah M. Mahachie; Johnson, D; Jones, Jonathan C. R.; Joram, C.; Jost, B.; Jurik, N.; Kandybei, S.; Kanso, W.; Karacson, M.; Kariuki, J. M.; Karodia, S.; Kecke, M.; Kelsey, M.; Kenyon, I. R.; Kenzie, M.; Ketel, T. J.; Khairullin, E.; Khanji, B.; Khurewathanakul, C.; Kirn, T.; Klaver, N. S.; Klimaszewski, K.; Koliiev, S.; Kolpin, M.; Komarov, I.; Koopman, R. F.; Koppenburg, P.; Kosmyntseva, A.; Kozachuk, A.; Kozeiha, M.; Kravchuk, Vladimir Leonidovich; Kreplin, K.; Kreps, M.; Krokovny, P.; Kruse, F.; Krzemien, W.; Kucewicz, W.; Kucharczyk, M.; Kudryavtsev, V.; Kuonen, A. K.; Kurek, K.; Kvaratskheliya, T.; Lacarrere, D.; Lafferty, G.; Lai, A.; Lanfranchi, G.; Langenbruch, C.; Latham, T.; Lazzeroni, C.; Le Gac, R.; Van Leerdam, J.; Lees, J. -P.; Leflat, A.; Lefrancois, J.; Lefevre, R.; Lemaitre, F.; Cid, E. Lemos; Leroy, O.; Lesiak, T.; Leverington, B.; Li, Y; Likhomanenko, T.; Lindner, R.; Linn, C.; Lionetto, F.; Liu, B.; Liu, X.; Loh, D.; Longstaff, I.; Lopes, J. H.; Lucchesi, D.; Lucio Martinez, M.; Luo, Haibin; Lupato, A.; Luppi, E.; Lupton, O.; Lusiani, A.; Lyu, X. R.; Machefert, F.; Maciuc, F.; Maev, O.; Maguire, Kate; Malde, S.; Malinin, A.; Maltsev, T.; Manca, G.; Mancinelli, G.; Manning, P.; Maratas, J.; Marchand, J. F.; Marconi, U.; Benito, C. Marin; Marino, Paolo; Marks, J. D.; Martellotti, G.; Martin, M.; Martinelli, M.; Santos, D. Martinez; Vidal, F. Martinez; Tostes, D. Martins; Massacrier, L. M.; Massafferri, A.; Matev, R.; Mathad, A.; Mathe, Z.; Matteuzzi, C.; Mauri, A.; Maurin, B.; Mazurov, A.; McCann, Linda M.; McCarthy, Patrick J.; McNab, A.; McNulty, R.; Meadows, B.; Meier, F.; Meissner, M.; Melnychuk, D.; Merk, M.; Merli, A.; Michielin, E.; Milanes, D. A.; Minard, M. -N.; Mitzel, D. S.; Mogini, A.; Rodriguez, J. Molina; Moreno-Monroy, Ana I.; Monteil, S.; Morandin, M.; Morawski, P.; Morda, A.; Morello, M. J.; Moron, J.; Morris, A. -B.; Mountain, R.; Muheim, F.; Mulder, M; Mussini, M.; Muller, D.; Muller, J.; Muller, K; Muller, V; Naik, P.; Nakada, T.; Nandakumar, R.; Nandi, A.; Nasteva, I.; Needham, M.; Neri, N.; Neubert, S.; Neufeld, N.; Neuner, M.; Nguyen, A. D.; Nguyen, T. D.; Nguyen-Mau, C.; Nieswand, S.; Niet, R.; Nikitin, N.; Nikodem, T.; Novoselov, A.; O'Hanlon, D. P.; Oblakowska-Mucha, A.; Obraztsov, V.; Ogilvy, S.; Oldeman, R.; Onderwater, C. J. G.; Goicochea, J. M. Otalora; Otto, A.; Owen, Randall P.; Oyanguren, A.; Pais, P. R.; Palano, A.; Palombo, F.; Palutan, M.; Panman, J.; Papanestis, A.; Pappagallo, M.; Pappalardo, L.; Parker, Anthony W.; Parkes, C.; Passaleva, G.; Pastore, A.; Patel, G. D.; Patel, M.; Patrignani, C.; Pearce, A.; Pellegrino, A.; Penso, G.; Altarelli, M. Pepe; Perazzini, S.; Perret, P.; Pescatore, L.; Petridis, K.; Petrolini, A.; Petrov, A. D.; Petruzzo, M.; Olloqui, E. Picatoste; Pietrzyk, B.; Pikies, M.; Pinci, D.; Pistone, A.; Piucci, A.; Playfer, S.; Casasus, M. Plo; Poikela, T.; Polci, F.; Poluektov, A.; Polyakov, I.; Polycarpo, E.; Pomery, G. J.; Popov, A.; Popov, D.; Popovici, B.; Poslavskii, S.; Potterat, C.; Price, P. E.; Price, Daniel J.; Prisciandaro, J.; Pritchard, A.; Prouve, C.; Pugatch, V.; Navarro, A. Puig; Punzi, G.; Qian, S. W.; Quagliani, R.; Rachwal, B.; Rademacker, J. H.; Rama, M.; Pernas, M. Ramos; Rangel, M. S.; Raniuk, I.; Ratnikov, F.; Raven, G.; Redi, F.; Reichert, Andreas S.; Dos Reis, A. C.; Alepuz, C. Remon; Renaudin, V.; Ricciardi, S.; Richards, S.; Rihl, M.; Rinnert, K.; Molina, V. Rives; Robbe, P.; Rodrigues, A. B.; Rodrigues, Eliane R.; Lopez, J. A. Rodriguez; Perez, P. Rodriguez; Rogozhnikov, A.; Roiser, S.; Rollings, A.; Romanovskiy, V.; Vidal, A. Romero; Ronayne, J. W.; Rotondo, M.; Ruf, Thomas; Valls, P. Ruiz; Silva, J. J. Saborido; Sadykhov, E.; Sagidova, N.; Saitta, B.; Guimaraes, V. Salustino; Mayordomo, C. Sanchez; Sedes, B. Sanmartin; Santacesaria, R.; Rios, C. Santamarina; Santimaria, M.; Santovetti, E.; Sarti, A.; Satriano, C.; Satta, A.; Saunders, D. M.; Savrina, D.; Schael, S.; Schellenberg, M.; Schiller, M.; Schindler, H.; Schlupp, M.; Schmelling, M.; Schmelzer, T.; Schmidt, B.; Schneider, O.; Schopper, A.; Schubert, K.; Schubiger, M.; Schune, M. -H.; Schwemmer, R.; Sciascia, B.; Sciubba, A.; Semennikov, A.; Sergi, A.; Serra, N.; Gonzalez-Serrano, J.; Sestini, L.; Seyfert, P.; Shapkin, M.; Shapoval, I.; Shcheglov, Y.; Shears, T.; Shekhtman, L.; Shevchenko, V.; Siddi, B. G.; Coutinho, R. Silva; Oliveira, L. Silva de; Simi, G.; Simone Doolaard, [No Value; Sirendi, M.; Skidmore, N.; Skwarnicki, T.; Smith, E.; Smith, I. T.; Smith, J; Smith, M; Snoek, H.; Sokoloff, M. D.; Soler, F. J. P.; De Paula, B. Souza; Spaan, B.; Spradlin, P.; Sridharan, S.; Stagni, F.; Stahl, M.; Stahl, Sherin S.; Stefko, P.; Stefkova, S.; Steinkamp, O.; Stemmle, S.; Stenyakin, O.; Stevenson, S.; Stoica, S.; Stone, Ian S.; Storaci, B.; Stracka, S.; Straticiuc, M.; Straumann, U.; Sun, L.; Sutcliffe, W.; Swientek, K.; Syropoulos, V.; Szczekowski, M.; Szumlak, T.; T'Jampens, S.; Tayduganov, A.; Tekampe, T.; Tellarini, G.; Teubert, F.; Thomas, E.; Tilburg, Jeroen J H C; Tilley, M. J.; Tisserand, V.; Tobin, M; Tolk, S.; Tomassetti, L.; Tonelli, D.; Topp-Joergensen, S.; Toriello, F.; Tournefier, E.; Tourneur, S.; Trabelsi, K.; Traill, M.; Tran, M. T.; Tresch, M.; Trisovic, A.; Tsaregorodtsev, A.; Tsopelas, P.; Tully, A.; Tuning, N.; Ukleja, A.; Ustyuzhanin, A.; Uwer, U.; Vacca, C.; Vagnoni, V.; Valassi, A.; Valat, S.; Valenti, G.; Vallier, A.; Gomez, R. Vazquez; Regueiro, P. Vazquez; Vecchi, S.; van Veghel, M.; Velthuis, Miranda J.; Veltri, M.; Veneziano, G.; Venkateswaran, A.; Vernet, M.; Vesterinen, M.; Viaud, B.; VIEIRA, DF; Diaz, M. Vieites; Viemann, H.; Vilasis-Cardona, X.; Vitti, M.; Volkov, V.; Vollhardt, A.; Voneki, B.; Vorobyev, A.; Vorobyev, V.; Voss, C.; de Vries, J. A.; Sierra, C. Vazquez; Waldi, R.; Wallace, C.; Wallace, R; Walsh, J.; Wang, J; Ward, D. R.; Wark, H. M.; Watson, N. K.; Websdale, D.; Weiden, A.; Whitehead, M.; Wicht, J.; Wilkinson, G.; Wilkinson, M.; Williams, M.; Williams, M.; Williams, M.; Williams, Tishan; Wilson, F. Perry; Wimberley, J.; Wishahi, J.; Wislicki, W.; Witek, M.; Wormser, G.; Wotton, S. A.; Wraight, K.; Wyllie, K.; Xie, Y; Xing, Zhe; Xu, Z.; Yang, Z.; Yin, H.; Yu, J.; Yuan, X.-L.; Yushchenko, O.; Zarebski, K. A.; Zavertyaev, M.; Zhang, L; Zhang, Y.; Zhang, Y.; Zhelezov, A.; Zheng, Y.; Zhokhov, A.; Zhu, X.; Zhukov, V.; Zucchelli, S.; Rudolph, M.S.

    2017-01-01

    The decays B+-> J/psi 3 pi(+)2 pi(-) and B+ -> psi(2S)pi(+)pi(+)pi(-) are observed for the first time using a data sample corresponding to an integrated luminosity of 3.0 fb(-1), collected by the LHCb experiment in proton- proton collisions at the centre-of-mass energies of 7 and 8 TeV. The

  12. Effect of running exercise on the number of the neurons in the hippocampus of young transgenic APP/PS1 mice.

    Science.gov (United States)

    Jiang, Lin; Ma, Jing; Zhang, Yi; Zhou, Chun-Ni; Zhang, Lei; Chao, Feng-Lei; Chen, Lin-Mu; Jiang, Rong; Wu, Hong; Tang, Yong

    2018-08-01

    To investigate the effect of running exercise on the number of the neurons in the hippocampus of young APP/PS1 mice, twenty 6-month-old male APP/ PS1 transgenic mice were randomly divided into the APP/PS1 control (AD control) group and the APP/PS1 running (AD running) group (10 mice per group), and ten wild-type mice of the littermate were regarded as the wild-type (WT) group. The AD running mice ran on motorized treadmill machiene for 4 months, while the WT mice and AD control mice were housed in standard condition without running. Then, Morris water maze tests (MWM) were used to assess the special learning and memory abilities of mice in three groups. The stereological methods were used to quantitatively evaluate the volume of the hippocampus, CA1/2, CA3 and the dentate gyrus (DG) and count the number of the neurons in CA1/2, CA3 and DG. We found that 4-month running effectively shortened the escape latency of young APP/PS1 control mice in MWM. More importantly, 4-month running effectively increased the volumes of the hippocampus, CA1/2, CA3 and DG and increased the number of neurons in CA1/2, CA3 and DG in young APP/PS1 mice. The present results suggested that 4-month running has significant beneficial effects on the spatial learning and memory capacities of young APP/PS1 mice and could delay the progress of atrophy of hippocampus and the neuron death in CA1/2, CA3 and DG in young APP/PS1 mice. Copyright © 2018 Elsevier B.V. All rights reserved.

  13. GSK3 beta forms a tetrameric complex with endogenous PS1-CTF/NTF and beta-catenin. Effects of the D257/D385A and FAD-linked mutations.

    Science.gov (United States)

    Tesco, G; Tanzi, R E

    2000-01-01

    We have previously shown that the endogenous C-terminal fragment of presenilin 1 co-immunoprecipitates with endogenous beta-catenin. Since PS1 has been suggested to be involved in beta-catenin stabilization, we further investigated whether GSK3 beta, responsible for beta-catenin phosphorylation and degradation, is part of the PS1/beta-catenin complex. In naïve H4 and CHO cells, PS1 co-immunoprecipitated with both endogenous beta-catenin and GSK3 beta. In addition, GSK3 beta endogenously binds to the PS1-CTF/NTF complex and beta-catenin in naïve CHO cells. GSK3 beta also co-immunoprecipitated with PS1 full length in CHO cell lines overexpressing PS1 wild type. Given that it has been recently shown that PS1 mutations of aspartate 257 or 385 result in prevention of PS1 endoproteolysis and inhibition of gamma-secretase activity, we also tested whether PS1 endoproteolysis is required for beta-catenin/GSK3 beta/PS1 binding and whether PS1 FAD-linked mutations affect GSK3 beta recruitment in the PS1/beta-catenin complex. GSK3 beta was detected in PS1 immunoprecipitates from H4 cell lines overexpressing PS1 wild type, delta E10, A286E, L246V and in CHO cell lines overexpressing aspartate or M146L mutations. The latter data show that the absence of PS1 endoproteolysis (D257A/D385A and delta E10) or the presence of PS1-FAD mutations does not interfere with beta-catenin/GSK3 beta/PS1 complex formation.

  14. Adnyamathanha Night Skies

    Science.gov (United States)

    Curnow, Paul

    2009-06-01

    Aboriginal Australians have been viewing the night skies of Australia for some 45,000 years and possibly much longer. During this time they have been able to develop a complex knowledge of the night sky, the terrestrial environment in addition to seasonal changes. However, few of us in contemporary society have an in-depth knowledge of the nightly waltz of stars above.

  15. PS1-10jh CONTINUES TO FOLLOW THE FALLBACK ACCRETION RATE OF A TIDALLY DISRUPTED STAR

    Energy Technology Data Exchange (ETDEWEB)

    Gezari, S. [Department of Astronomy, University of Maryland, Stadium Drive, College Park, MD 20742-2421 (United States); Chornock, R. [Astrophysical Institute, Department of Physics and Astronomy, 251B Clippinger Lab, Ohio University Athens, OH 45701 (United States); Lawrence, A. [Institute for Astronomy, University of Edinburgh Scottish Universities Physics Alliance, Royal Observatory, Blackford Hill, Edinburgh EH9 3HJ (United Kingdom); Rest, A. [Space Telescope Science Institute, 3700 San Martin Drive, Baltimore, MD 21218 (United States); Jones, D. O. [Department of Physics and Astronomy, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218 (United States); Berger, E.; Challis, P. M. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Narayan, G., E-mail: suvi@astro.umd.edu [NOAO, 950 North Cherry Avenue, Tucson, AZ 85719 (United States)

    2015-12-10

    We present late-time observations of the tidal disruption event candidate PS1-10jh. UV and optical imaging with Hubble Space Telescope/WFC3 localize the transient to be coincident with the host galaxy nucleus to an accuracy of 0.023 arcsec, corresponding to 66 pc. The UV flux in the F225W filter, measured 3.35 rest-frame years after the peak of the nuclear flare, is consistent with a decline that continues to follow a t{sup −5/3} power-law with no spectral evolution. Late epochs of optical spectroscopy obtained with MMT ∼ 2 and 4 years after the peak, enable a clean subtraction of the host galaxy from the early spectra, revealing broad helium emission lines on top of a hot continuum, and placing stringent upper limits on the presence of hydrogen line emission. We do not measure Balmer Hδ absorption in the host galaxy that is strong enough to be indicative of a rare, post-starburst “E+A” galaxy as reported by Arcavi et al. The light curve of PS1-10jh over a baseline of 3.5 years is best modeled by fallback accretion of a tidally disrupted star. Its strong broad helium emission relative to hydrogen (He iiλ4686/Hα > 5) could be indicative of either the hydrogen-poor chemical composition of the disrupted star, or certain conditions in the tidal debris of a solar-composition star in the presence of an optically thick, extended reprocessing envelope.

  16. TREM2 Overexpression has No Improvement on Neuropathology and Cognitive Impairment in Aging APPswe/PS1dE9 Mice.

    Science.gov (United States)

    Jiang, Teng; Wan, Yu; Zhang, Ying-Dong; Zhou, Jun-Shan; Gao, Qing; Zhu, Xi-Chen; Shi, Jian-Quan; Lu, Huan; Tan, Lan; Yu, Jin-Tai

    2017-03-01

    Previously, we showed that overexpression of triggering receptor expressed on myeloid cells 2 (TREM2), a microglia-specific immune receptor, in the brain of a middle-aged (7 months old) APPswe/PS1dE9 mice could ameliorate Alzheimer's disease (AD)-related neuropathology by enhancement of microglial amyloid-β (Aβ) phagocytosis. Since AD is an age-related neurodegenerative disorder, it is critical to assess the efficacy of TREM2 overexpression in aging animals with an advanced disease stage. In vivo, we employed a lentiviral strategy to overexpress TREM2 in the brain of aging (18 months old) APPswe/PS1dE9 mice, and observed its efficacy on AD-related neuropathology and cognitive functions. Afterwards, we directly isolated microglia from middle-aged and aging APPswe/PS1dE9 mice and determined effects of TREM2 overexpression on microglial Aβ phagocytosis and Aβ-binding receptors expression in vitro. In aging APPswe/PS1dE9 mice, TREM2 overexpression has no beneficial effect on AD-related neuropathology and spatial cognitive functions. Of note, in vitro experiments showed a significant reduction of Aβ phagocytosis in microglia from aging APPswe/PS1dE9 mice, possibly attributing to the declined expression of Aβ-binding receptors. Meanwhile, this phagocytic deficit in microglia from aging APPswe/PS1dE9 mice cannot be rescued by TREM2 overexpression. Taken together, our study shows that TREM2 overexpression fails to provide neuroprotection in aging APPswe/PS1dE9 mice, possibly attributing to deficits in microglial Aβ phagocytosis at the late-stage of disease progression. These findings indicate that TREM2-mediated protection in AD is at least partially dependent on the reservation of microglial phagocytic functions, emphasizing the importance of early therapeutic interventions for this devastating disease.

  17. PPARγ agonist pioglitazone improves cerebellar dysfunction at pre-Aβ deposition stage in APPswe/PS1dE9 Alzheimer's disease model mice

    Energy Technology Data Exchange (ETDEWEB)

    Toba, Junya; Nikkuni, Miyu [Laboratory for Molecular Brain Science, Department of Life Science and Medical Bioscience, Graduate School of Advanced Science and Engineering, Waseda University, Tokyo, 162-8480 Japan (Japan); Ishizeki, Masato [Laboratory for Neurophysiology, Department of Life Science and Medical Bioscience, Graduate School of Advanced Science and Engineering, Waseda University, Tokyo, 162-8480 Japan (Japan); Yoshii, Aya; Watamura, Naoto [Laboratory for Molecular Brain Science, Department of Life Science and Medical Bioscience, Graduate School of Advanced Science and Engineering, Waseda University, Tokyo, 162-8480 Japan (Japan); Inoue, Takafumi [Laboratory for Neurophysiology, Department of Life Science and Medical Bioscience, Graduate School of Advanced Science and Engineering, Waseda University, Tokyo, 162-8480 Japan (Japan); Ohshima, Toshio, E-mail: ohshima@waseda.jp [Laboratory for Molecular Brain Science, Department of Life Science and Medical Bioscience, Graduate School of Advanced Science and Engineering, Waseda University, Tokyo, 162-8480 Japan (Japan)

    2016-05-13

    Alzheimer's disease (AD) is one of the best known neurodegenerative diseases; it causes dementia and its pathological features include accumulation of amyloid β (Aβ) and neurofibrillary tangles (NFTs) in the brain. Elevated Cdk5 activity and CRMP2 phosphorylation have been reported in the brains of AD model mice at the early stage of the disease, but the significance thereof in human AD remains unelucidated. We have recently reported that Aβ accumulation in the cerebellum of AD model APPswe/PS1dE9 (APP/PS1) mice, and cerebellar dysfunctions, such as impairment of motor coordination ability and long-term depression (LTD) induction, at the pre-Aβ accumulation stage. In the present study, we found increased phosphorylation levels of CRMP2 as well as increased p35 protein levels in the cerebellum of APP/PS1 mice. Interestingly, we show that pioglitazone, an agonist of peroxisome proliferator-activated receptor γ, normalized the p35 protein and CRMP2 phosphorylation levels in the cerebellum. Impaired motor coordination ability and LTD in APP/PS1 mice were ameliorated by pioglitazone treatment at the pre-Aβ accumulation stage. These results suggest a correlation between CRMP2 phosphorylation and AD pathophysiology, and indicate the effectiveness of pioglitazone treatment at the pre-Aβ accumulation stage in AD model mice. -- Highlights: •Phosphorylation level of CRMP2 increased in the cerebellum of APP/PS1 mice. •p35 protein levels increased in the cerebellum of APP/PS1 mice. •Pioglitazone treatment improved cerebellar dysfunction of APP/PS1 mice.

  18. PPARγ agonist pioglitazone improves cerebellar dysfunction at pre-Aβ deposition stage in APPswe/PS1dE9 Alzheimer's disease model mice

    International Nuclear Information System (INIS)

    Toba, Junya; Nikkuni, Miyu; Ishizeki, Masato; Yoshii, Aya; Watamura, Naoto; Inoue, Takafumi; Ohshima, Toshio

    2016-01-01

    Alzheimer's disease (AD) is one of the best known neurodegenerative diseases; it causes dementia and its pathological features include accumulation of amyloid β (Aβ) and neurofibrillary tangles (NFTs) in the brain. Elevated Cdk5 activity and CRMP2 phosphorylation have been reported in the brains of AD model mice at the early stage of the disease, but the significance thereof in human AD remains unelucidated. We have recently reported that Aβ accumulation in the cerebellum of AD model APPswe/PS1dE9 (APP/PS1) mice, and cerebellar dysfunctions, such as impairment of motor coordination ability and long-term depression (LTD) induction, at the pre-Aβ accumulation stage. In the present study, we found increased phosphorylation levels of CRMP2 as well as increased p35 protein levels in the cerebellum of APP/PS1 mice. Interestingly, we show that pioglitazone, an agonist of peroxisome proliferator-activated receptor γ, normalized the p35 protein and CRMP2 phosphorylation levels in the cerebellum. Impaired motor coordination ability and LTD in APP/PS1 mice were ameliorated by pioglitazone treatment at the pre-Aβ accumulation stage. These results suggest a correlation between CRMP2 phosphorylation and AD pathophysiology, and indicate the effectiveness of pioglitazone treatment at the pre-Aβ accumulation stage in AD model mice. -- Highlights: •Phosphorylation level of CRMP2 increased in the cerebellum of APP/PS1 mice. •p35 protein levels increased in the cerebellum of APP/PS1 mice. •Pioglitazone treatment improved cerebellar dysfunction of APP/PS1 mice.

  19. 2014 Australasian sky guide

    CERN Document Server

    Lomb, Nick

    2013-01-01

    Compact, easy to use and reliable, this popular guide contains everything you need to know about the southern night sky with monthly astronomy maps, viewing tips and highlights, and details of all the year's exciting celestial events. Wherever you are in Australia or New Zealand, easy calculations allow you to estimate local rise and set times for the Sun, Moon and planets. The 2014 Australasian Sky Guide also provides information on the solar system, updated with the latest findings from space probes. Published annually since 1991, the Sky Guide continues to be a favourite with photographers,

  20. Observation of B+ -> J/psi 3 pi(+)2 pi(-) and B+ -> psi (2S)pi(+)pi(+)pi(-) decays

    OpenAIRE

    Aaij, R.; Adeva, B.; Adinolfi, M.; Ajaltouni, Z.; Akar, S.; Albrecht, J.; Alessio, F.; Alexander, M. H.; Ali, S.; Alkhazov, G.; Cartelle, P. Alvarez; Alves, A. A. Jr; Amato, S.; Amerio, S.; Amhis, Y.

    2017-01-01

    The decays B+-> J/psi 3 pi(+)2 pi(-) and B+ -> psi(2S)pi(+)pi(+)pi(-) are observed for the first time using a data sample corresponding to an integrated luminosity of 3.0 fb(-1), collected by the LHCb experiment in proton- proton collisions at the centre-of-mass energies of 7 and 8 TeV. The branching fractions relative to that of B+ -> psi(2S)K+ are measured to be B(B+-> J/psi 3 pi(+)2 pi(-))/B(B+ -> psi (2S)K+) = (1.88 +/- 0.17 +/- 0.09)x10(-2). B(B+ -> psi(2S)pi(+)pi(+)pi(-))/B(B+ -> psi (2...

  1. GABA(A receptor-mediated acceleration of aging-associated memory decline in APP/PS1 mice and its pharmacological treatment by picrotoxin.

    Directory of Open Access Journals (Sweden)

    Yuji Yoshiike

    Full Text Available Advanced age and mutations in the genes encoding amyloid precursor protein (APP and presenilin (PS1 are two serious risk factors for Alzheimer's disease (AD. Finding common pathogenic changes originating from these risks may lead to a new therapeutic strategy. We observed a decline in memory performance and reduction in hippocampal long-term potentiation (LTP in both mature adult (9-15 months transgenic APP/PS1 mice and old (19-25 months non-transgenic (nonTg mice. By contrast, in the presence of bicuculline, a GABA(A receptor antagonist, LTP in adult APP/PS1 mice and old nonTg mice was larger than that in adult nonTg mice. The increased LTP levels in bicuculline-treated slices suggested that GABA(A receptor-mediated inhibition in adult APP/PS1 and old nonTg mice was upregulated. Assuming that enhanced inhibition of LTP mediates memory decline in APP/PS1 mice, we rescued memory deficits in adult APP/PS1 mice by treating them with another GABA(A receptor antagonist, picrotoxin (PTX, at a non-epileptic dose for 10 days. Among the saline vehicle-treated groups, substantially higher levels of synaptic proteins such as GABA(A receptor alpha1 subunit, PSD95, and NR2B were observed in APP/PS1 mice than in nonTg control mice. This difference was insignificant among PTX-treated groups, suggesting that memory decline in APP/PS1 mice may result from changes in synaptic protein levels through homeostatic mechanisms. Several independent studies reported previously in aged rodents both an increased level of GABA(A receptor alpha1 subunit and improvement of cognitive functions by long term GABA(A receptor antagonist treatment. Therefore, reduced LTP linked to enhanced GABA(A receptor-mediated inhibition may be triggered by aging and may be accelerated by familial AD-linked gene products like Abeta and mutant PS1, leading to cognitive decline that is pharmacologically treatable at least at this stage of disease progression in mice.

  2. Effects of short-term Western diet on cerebral oxidative stress and diabetes related factors in APP x PS1 knock-in mice.

    Science.gov (United States)

    Studzinski, Christa M; Li, Feng; Bruce-Keller, Annadora J; Fernandez-Kim, Sun Ok; Zhang, Le; Weidner, Adam M; Markesbery, William R; Murphy, M Paul; Keller, Jeffrey N

    2009-02-01

    A chronic high fat Western diet (WD) promotes a variety of morbidity factors although experimental evidence for short-term WD mediating brain dysfunction remains to be elucidated. The amyloid precursor protein and presenilin-1 (APP x PS1) knock-in mouse model has been demonstrated to recapitulate some key features of Alzheimer's disease pathology, including amyloid-beta (Abeta) pathogenesis. In this study, we placed 1-month-old APP x PS1 mice and non-transgenic littermates on a WD for 4 weeks. The WD resulted in a significant elevation in protein oxidation and lipid peroxidation in the brain of APP x PS1 mice relative to non-transgenic littermates, which occurred in the absence of increased Abeta levels. Altered adipokine levels were also observed in APP x PS1 mice placed on a short-term WD, relative to non-transgenic littermates. Taken together, these data indicate that short-term WD is sufficient to selectively promote cerebral oxidative stress and metabolic disturbances in APP x PS1 knock-in mice, with increased oxidative stress preceding alterations in Abeta. These data have important implications for understanding how WD may potentially contribute to brain dysfunction and the development of neurodegenerative disorders such as Alzheimer's disease.

  3. Chronic stress induced cognitive impairment in APP/PS-1 double transgenic mouse model of Alzheimer's disease

    Directory of Open Access Journals (Sweden)

    Bing HAN

    2015-08-01

    Full Text Available Objective  To observe the effect of chronic unpredictable mild stress (CUMS on the cognitive function and brain morphological changes in APP/PS-1 mice, one of the genetic mouse models of Alzheimer's disease (AD, and to investigate the possible role of environmental factors in genetic mouse model of AD. Methods  There were 22-week-old wild-type C57BL/6 male mice (control group, N = 15 and APP/PS-1 double transgenic male mice [N = 27: AD group (N = 13 and AD + CUMS group (N = 14] tested in this study. Morris water maze test was used to evaluate spatial learning and memory of the mice. Amyloid deposition in the hippocampus was determined by Congo red staining. The ultrastructure of neurons in hippocampal CA1 region was observed by transmission electron microscope (TEM.  Results  Compared with control group, AD + CUMS group had significantly longer fifth-day escape latency [(33.14 ± 14.37 s vs (21.22 ± 12.16 s; t = -2.701, P = 0.045], and significantly shortened time spent in platform quadrant [(9.74±1.35 s vs (15.02 ± 1.33 s; t = 2.639, P = 0.012] in Morris water maze test. Compared with AD group, the percentage of amyloid plaque area in hippocampal area was increased in AD + CUMS group [(0.59 ± 0.03% vs (0.04 ± 0.03%; t = -2.900, P = 0.005]. The ultrastructure of hippocampal neurons in AD group was slightly damaged: cellular membrane was intact; cell matrix was uniform; intracelluar lipofuscin could be seen; the structure of nucleus and nuclear membrane had no obvious changes; mild fusion of cristae and membrane was seen in mitochondria; Golgi apparatus was partially indistinct; endoplasmic reticulum was mildly expanded. The ultrastructure of hippocampal neurons in AD + CUMS group was obviously damaged, including blurred cell membrane, reduced low-density and high-density granules in cytoplasm, uneven cell matrix, reduced number of organelles, lipofuscin and autophagosome deposition, obvious condensation of chromatin distributing over

  4. Curcumin regulates insulin pathways and glucose metabolism in the brains of APPswe/PS1dE9 mice.

    Science.gov (United States)

    Wang, Pengwen; Su, Caixin; Feng, Huili; Chen, Xiaopei; Dong, Yunfang; Rao, Yingxue; Ren, Ying; Yang, Jinduo; Shi, Jing; Tian, Jinzhou; Jiang, Shucui

    2017-03-01

    Recent studies have shown the therapeutic potential of curcumin in Alzheimer's disease (AD). In 2014, our lab found that curcumin reduced Aβ40, Aβ42 and Aβ-derived diffusible ligands in the mouse hippocampus, and improved learning and memory. However, the mechanisms underlying this biological effect are only partially known. There is considerable evidence in brain metabolism studies indicating that AD might be a brain-specific type of diabetes with progressive impairment of glucose utilisation and insulin signalling. We hypothesised that curcumin might target both the glucose metabolism and insulin signalling pathways. In this study, we monitored brain glucose metabolism in living APPswe/PS1dE9 double transgenic mice using a micro-positron emission tomography (PET) technique. The study showed an improvement in cerebral glucose uptake in AD mice. For a more in-depth study, we used immunohistochemical (IHC) staining and western blot techniques to examine key factors in both glucose metabolism and brain insulin signalling pathways. The results showed that curcumin ameliorated the defective insulin signalling pathway by upregulating insulin-like growth factor (IGF)-1R, IRS-2, PI3K, p-PI3K, Akt and p-Akt protein expression while downregulating IR and IRS-1. Our study found that curcumin improved spatial learning and memory, at least in part, by increasing glucose metabolism and ameliorating the impaired insulin signalling pathways in the brain.

  5. Dexibuprofen prevents neurodegeneration and cognitive decline in APPswe/PS1dE9 through multiple signaling pathways

    Directory of Open Access Journals (Sweden)

    Miren Ettcheto

    2017-10-01

    Full Text Available The aim of the present study is to elucidate the neuronal pathways associated to NSAIDs causing a reduction of the risk and progression of Alzheimer's disease. The research was developed administering the active enantiomer of ibuprofen, dexibuprofen (DXI, in order to reduce associated gastric toxicity. DXI was administered from three to six-month-old female APPswe/PS1dE9 mice as a model of familial Alzheimer's disease. DXI treatment reduced the activation of glial cells and the cytokine release involved in the neurodegenerative process, especially TNFα. Moreover, DXI reduced soluble β-amyloid (Aβ1-42 plaque deposition by decreasing APP, BACE1 and facilitating Aβ degradation by enhancing insulin-degrading enzyme. DXI also decreased TAU hyperphosphorylation inhibiting c-Abl/CABLES/p-CDK5 activation signal pathway and prevented spatial learning and memory impairment in transgenic mice. Therefore, chronic DXI treatment could constitute a potential AD-modifying drug, both restoring cognitive functions and reversing multiple brain neuropathological hallmarks.

  6. A comparative evaluation of a novel vaccine in APP/PS1 mouse models of Alzheimer's disease.

    Science.gov (United States)

    Carrera, Iván; Etcheverría, Ignacio; Fernández-Novoa, Lucía; Lombardi, Valter Ruggero Maria; Lakshmana, Madepalli Krishnappa; Cacabelos, Ramón; Vigo, Carmen

    2015-01-01

    Immunization against amyloid-beta-peptide (Aβ) has been widely investigated as a potential immunotherapeutic approach for Alzheimer's disease (AD). With the aim of developing an active immunogenic vaccine without need of coadjuvant modification for human trials and therefore avoiding such side effects, we designed the Aβ 1-42 vaccine (EB101), delivered in a liposomal matrix, that based on our previous studies significantly prevents and reverses the AD neuropathology, clearing Aβ plaques while markedly reducing neuronal degeneration, behavioral deficits, and minimizing neuroinflammation in APP/PS1 transgenic mice. Here, the efficacy of our immunogenic vaccine EB101 was compared with the original immunization vaccine cocktail Aβ 42 + CFA/IFA (Freund's adjuvant), in order to characterize the effect of sphingosine-1-phosphate (S1P) in the immunotherapeutic response. Quantitative analysis of amyloid burden showed a notable decrease in the neuroinflammation reaction against Aβ plaques when S1P was compared with other treatments, suggesting that S1P plays a key role as a neuroprotective agent. Moreover, EB101 immunized mice presented a protective immunogenic reaction resulting in the increase of Aβ-specific antibody response and decrease of reactive glia in the affected brain areas, leading to a Th2 immunological reaction.

  7. Early-Life Stress Does Not Aggravate Spatial Memory or the Process of Hippocampal Neurogenesis in Adult and Middle-Aged APP/PS1 Mice

    Directory of Open Access Journals (Sweden)

    Lianne Hoeijmakers

    2018-03-01

    Full Text Available Life-time experiences are thought to influence the risk to develop the neurodegenerative disorder Alzheimer’s disease (AD. In particular, early-life stress (ES may modulate the onset and progression of AD. There is recent evidence by our group and others that AD-related neuropathological progression and the associated neuroimmune responses are modulated by ES in the classic APPswe/PS1dE9 mouse model for AD. We here extend our previous study on ES mediated modulation of neuropathology and neuroinflammation and address in the same cohort of mice whether ES accelerates and/or aggravates AD-induced cognitive decline and alterations in the process of adult hippocampal neurogenesis (AHN, a form of brain plasticity. Chronic ES was induced by limiting bedding and nesting material during the first postnatal week and is known to induce cognitive deficits by 4 months in wild type (WT mice. The onset of cognitive decline in APP/PS1 mice generally starts around 6 months of age. We here tested mice at ages 2–4 months to study acceleration and at ages 8–10 months for aggravation of the APP/PS1 phenotype. ES-exposed WT and APP/PS1 mice were able to perform the object recognition (ORT and location tasks (OLT at 2 months of age. Interestingly, at 3 months, ES induced impairments in the performance of the OLT in WT, but not in APP/PS1 mice. APP/PS1 mice exhibited alterations in hippocampal cell proliferation and differentiation, but ES exposure did not further change this. At 9 months, APP/PS1 mice exhibited impaired performance in the Morris Water Maze (MWM task, as well as reductions in markers of the AHN process, which were not further modulated by ES exposure. In addition, we observed a so far unreported hyperactivity in ES-exposed mice at 8 months of age, which hampered assessment of cognitive functions in the ORT and OLT. In conclusion, while ES has been reported to modulate AD neuropathology and neuroinflammation before, it failed to accelerate or

  8. Glio-vascular changes during ageing in wild-type and Alzheimer's disease-like APP/PS1 mice.

    Science.gov (United States)

    Janota, C S; Brites, D; Lemere, C A; Brito, M A

    2015-09-16

    Vascular and glial involvement in the development of neurodegenerative disorders, such as Alzheimer's disease (AD), and age-related brain vulnerabilities have been suggested. Therefore, we sought to: (i) investigate which vascular and glial events are evident in ageing and/or AD, (ii) to establish the temporal evolution of vascular and glial changes in AD-like and wild-type (WT) mice and (iii) to relate them to amyloid-β (Aβ) peptide accumulation. We examined immunohistochemically hippocampi and cortex from APP/PS1dE9 and WT C57BL/6 mice along ageing and disease progression (young-adulthood, middle- and old-age). Ageing resulted in the increase in receptor for advanced glycation endproducts expression, as well as the entrance of thrombin and albumin in hippocampal parenchyma. In contrast, the loss of platelet-derived growth factor receptor-β (PDGFR-β) positive cells, in both regions, was only related to AD pathogenesis. Hypovascularization was affected by both ageing and AD in the hippocampus, but resulted from the interaction between both factors in the cortex. Astrogliosis was a result of AD in hippocampus and of both factors in cortex, while microgliosis was associated with fibrillar amyloid plaques in AD-like mice and with the interaction between both factors in each of the studied regions. In sum, these data show that senile plaques precede vascular and glial alterations only in hippocampus, whereas in cortex, vascular and glial alterations, namely the loss of PDGFR-β-positive cells and astrogliosis, accompanied the first senile plaques. Hence, this study points to vascular and glial events that co-exist in AD pathogenesis and age-related brain vulnerabilities. Copyright © 2015 Elsevier B.V. All rights reserved.

  9. A Chinese sky trust?

    Energy Technology Data Exchange (ETDEWEB)

    Brenner, Mark [Political Economy Research Institute, University of Massachusetts, Amherst (United States)]. E-mail: brenner@econs.umass.edu; Riddle, Matthew [Department of Economics, University of Massachusetts, Amherst (United States)]. E-mail: mriddle@econs.umass.edu; Boyce, James K. [Political Economy Research Institute and Department of Economics, University of Massachusetts, Amherst (United States)]. E-mail: boyce@econs.umass.edu

    2007-03-15

    The introduction of carbon charges on the use of fossil fuels in China would have a progressive impact on income distribution. This outcome, which contrasts to the regressive distributional impact found in most studies of carbon charges in industrialized countries, is driven primarily by differences between urban and rural expenditure patterns. If carbon revenues were recycled on an equal per capita basis via a 'sky trust,' the progressive impact would be further enhanced: low-income (mainly rural) households would receive more in sky-trust dividends than they pay in carbon charges, and high-income (mainly urban) households would pay more than they receive in dividends. Thus a Chinese sky trust would contribute to both lower fossil fuel consumption and greater income equality.

  10. A Chinese sky trust?

    International Nuclear Information System (INIS)

    Brenner, Mark; Riddle, Matthew; Boyce, James K.

    2007-01-01

    The introduction of carbon charges on the use of fossil fuels in China would have a progressive impact on income distribution. This outcome, which contrasts to the regressive distributional impact found in most studies of carbon charges in industrialized countries, is driven primarily by differences between urban and rural expenditure patterns. If carbon revenues were recycled on an equal per capita basis via a 'sky trust,' the progressive impact would be further enhanced: low-income (mainly rural) households would receive more in sky-trust dividends than they pay in carbon charges, and high-income (mainly urban) households would pay more than they receive in dividends. Thus a Chinese sky trust would contribute to both lower fossil fuel consumption and greater income equality

  11. Obesity and Hepatic Steatosis Are Associated with Elevated Serum Amyloid Beta in Metabolically Stressed APPswe/PS1dE9 Mice.

    Directory of Open Access Journals (Sweden)

    Feng-Shiun Shie

    Full Text Available Diabesity-associated metabolic stresses modulate the development of Alzheimer's disease (AD. For further insights into the underlying mechanisms, we examine whether the genetic background of APPswe/PS1dE9 at the prodromal stage of AD affects peripheral metabolism in the context of diabesity. We characterized APPswe/PS1dE9 transgenic mice treated with a combination of high-fat diet with streptozotocin (HFSTZ in the early stage of AD. HFSTZ-treated APPswe/PS1dE9 transgenic mice exhibited worse metabolic stresses related to diabesity, while serum β-amyloid levels were elevated and hepatic steatosis became apparent. Importantly, two-way analysis of variance shows a significant interaction between HFSTZ and genetic background of AD, indicating that APPswe/PS1dE9 transgenic mice are more vulnerable to HFSTZ treatment. In addition, body weight gain, high hepatic triglyceride, and hyperglycemia were positively associated with serum β-amyloid, as validated by Pearson's correlation analysis. Our data suggests that the interplay between genetic background of AD and HFSTZ-induced metabolic stresses contributes to the development of obesity and hepatic steatosis. Alleviating metabolic stresses including dysglycemia, obesity, and hepatic steatosis could be critical to prevent peripheral β-amyloid accumulation at the early stage of AD.

  12. Gender-Specific Hippocampal Dysrhythmia and Aberrant Hippocampal and Cortical Excitability in the APPswePS1dE9 Model of Alzheimer’s Disease

    Directory of Open Access Journals (Sweden)

    Anna Papazoglou

    2016-01-01

    Full Text Available Alzheimer’s disease (AD is a multifactorial disorder leading to progressive memory loss and eventually death. In this study an APPswePS1dE9 AD mouse model has been analyzed using implantable video-EEG radiotelemetry to perform long-term EEG recordings from the primary motor cortex M1 and the hippocampal CA1 region in both genders. Besides motor activity, EEG recordings were analyzed for electroencephalographic seizure activity and frequency characteristics using a Fast Fourier Transformation (FFT based approach. Automatic seizure detection revealed severe electroencephalographic seizure activity in both M1 and CA1 deflection in APPswePS1dE9 mice with gender-specific characteristics. Frequency analysis of both surface and deep EEG recordings elicited complex age, gender, and activity dependent alterations in the theta and gamma range. Females displayed an antithetic decrease in theta (θ and increase in gamma (γ power at 18-19 weeks of age whereas related changes in males occurred earlier at 14 weeks of age. In females, theta (θ and gamma (γ power alterations predominated in the inactive state suggesting a reduction in atropine-sensitive type II theta in APPswePS1dE9 animals. Gender-specific central dysrhythmia and network alterations in APPswePS1dE9 point to a functional role in behavioral and cognitive deficits and might serve as early biomarkers for AD in the future.

  13. Chronic caffeine treatment reverses memory impairment and the expression of brain BNDF and TrkB in the PS1/APP double transgenic mouse model of Alzheimer's disease.

    Science.gov (United States)

    Han, Kun; Jia, Ning; Li, Ji; Yang, Li; Min, Lian-Qiu

    2013-09-01

    The objective of this study was to investigate the effects of varying doses of caffeine on memory impairment and the expression of brain neurotrophic derived factor (BNDF) and TrkB in PS1/APP double transgenic mouse models. PS1/APP double transgenic mice were administered 0.3 ml/day of saline, 1.5 mg/day of caffeine or 0.75 mg/day of caffeine for eight weeks. A water maze test and western blotting were used to determine the memory capability and expression of hippocampal BNDF and TrkB of the mice. The results demonstrated that 0.75 mg/day and 1.5 mg/day doses of caffeine significantly increased memory capability and the expression of hippocampal BDNF and TrkB in PS1/APP mice with a dose-response effect. The results suggested that chronic caffeine treatment may reverse memory impairment in PS1/APP transgenic mice, and BDNF and its receptor TrkB, may be involved in this process.

  14. Dark-Skies Awareness

    Science.gov (United States)

    Walker, Constance E.

    2009-05-01

    The arc of the Milky Way seen from a truly dark location is part of our planet's natural heritage. More than one fifth of the world population, two thirds of the United States population and one half of the European Union population have already lost naked eye visibility of the Milky Way. This loss, caused by light pollution, is a serious and growing issue that impacts astronomical research, the economy, ecology, energy conservation, human health, public safety and our shared ability to see the night sky. For this reason, "Dark Skies” is a cornerstone project of the International Year of Astronomy. Its goal is to raise public awareness of the impact of artificial lighting on local environments by getting people worldwide involved in a variety of programs that: 1. Teach about dark skies using new technology (e.g., an activity-based planetarium show on DVD, podcasting, social networking on Facebook and MySpace, a Second Life presence) 2. Provide thematic events on light pollution at star parties and observatory open houses (Dark Skies Discovery Sites, Nights in the (National) Parks, Sidewalk Astronomy) 3. Organize events in the arts (e.g., a photography contest) 4. Involve citizen-scientists in naked-eye and digital-meter star hunting programs (e.g., GLOBE at Night, "How Many Stars?", the Great World Wide Star Count and the radio frequency interference equivalent: "Quiet Skies") and 5. Raise awareness about the link between light pollution and public health, economic issues, ecological consequences, energy conservation, safety and security, and astronomy (e.g., The Starlight Initiative, World Night in Defense of Starlight, International Dark Sky Week, International Dark-Sky Communities, Earth Hour, The Great Switch Out, a traveling exhibit, downloadable posters and brochures). The presentation will provide an update, describe how people can become involved and take a look ahead at the program's sustainability. For more information, visit www.darkskiesawareness.org.

  15. Fireballs in the Sky

    Science.gov (United States)

    Day, B. H.; Bland, P.

    2016-12-01

    Fireballs in the Sky is an innovative Australian citizen science program that connects the public with the research of the Desert Fireball Network (DFN). This research aims to understand the early workings of the solar system, and Fireballs in the Sky invites people around the world to learn about this science, contributing fireball sightings via a user-friendly app. To date, more than 23,000 people have downloaded the app world-wide and participated in planetary science. The Fireballs in the Sky app allows users to get involved with the Desert Fireball Network research, supplementing DFN observations and providing enhanced coverage by reporting their own meteor sightings to DFN scientists. Fireballs in the Sky reports are used to track the trajectories of meteors - from their orbit in space to where they might have landed on Earth. Led by Phil Bland at Curtin University in Australia, the Desert Fireball Network (DFN) uses automated observatories across Australia to triangulate trajectories of meteorites entering the atmosphere, determine pre-entry orbits, and pinpoint their fall positions. Each observatory is an autonomous intelligent imaging system, taking 1000×36Megapixel all-sky images throughout the night, using neural network algorithms to recognize events. They are capable of operating for 12 months in a harsh environment, and store all imagery collected. We developed a completely automated software pipeline for data reduction, and built a supercomputer database for storage, allowing us to process our entire archive. The DFN currently stands at 50 stations distributed across the Australian continent, covering an area of 2.5 million km^2. Working with DFN's partners at NASA's Solar System Exploration Research Virtual Institute, the team is expanding the network beyond Australia to locations around the world. Fireballs in the Sky allows a growing public base to learn about and participate in this exciting research.

  16. Production of $3\\pi^{0}$ and $\\eta2\\pi^{0}$ from $\\pi^{-}p$ collision in GAMS experiment

    CERN Document Server

    Kobayashi, Masaaki; Takamatsu, Kunio; Ishida, Shin; Komada, Toshihiko; Wakabayashi, Ayumu; Ishida, Muneyuki; Kobayashi, Masaaki; Tsuru, Tsuneaki; Takamatsu, Kunio; Ishida, Shin; Komada, Toshihiko; Wakabayashi, Ayumu; Ishida, Muneyuki

    2000-01-01

    The data on the pi- p --> M0 n, with M0 = pi0 pi0 pi0 or pi0 pi0 eta obtained in the GAMS experiment may be useful to study the sigma(400--700) and a_1^chi (1000), which can be taken as chiral partners of pi and rho, respectively. A preliminary analysis for 3pi0 invariant mass spectra gives a support for the assumed a_1^chi with a mass of 930 MeV and Gamma = 170 MeV.

  17. Measurement of the {eta}{yields}3{pi}{sup 0} slope parameter {alpha} with the KLOE detector

    Energy Technology Data Exchange (ETDEWEB)

    Ambrosino, F., E-mail: Fabio.Ambrosino@na.infn.i [Dipartimento di Scienze Fisiche dell' Universita ' Federico II' , Napoli (Italy); INFN Sezione di Napoli, Napoli (Italy); Antonelli, A.; Antonelli, M. [Laboratori Nazionali di Frascati dell' INFN, Frascati (Italy); Archilli, F. [Dipartimento di Fisica dell' Universita ' Tor Vergata' , Roma (Italy); INFN Sezione di Roma Tor Vergata, Roma (Italy); Beltrame, P. [Institut fuer Kernphysik, Johannes Gutenberg-Universitaet Mainz (Germany); Bencivenni, G. [Laboratori Nazionali di Frascati dell' INFN, Frascati (Italy); Bini, C. [Dipartimento di Fisica dell' Universita ' La Sapienza' , Roma (Italy); INFN Sezione di ' La Sapienza' , Roma (Italy); Bloise, C. [Laboratori Nazionali di Frascati dell' INFN, Frascati (Italy); Bocchetta, S. [Dipartimento di Fisica dell' Universita ' Roma Tre' , Roma (Italy); INFN Sezione di Roma Tre, Roma (Italy); Bossi, F. [Laboratori Nazionali di Frascati dell' INFN, Frascati (Italy); Branchini, P. [INFN Sezione di Roma Tre, Roma (Italy); Campana, P.; Capon, G. [Laboratori Nazionali di Frascati dell' INFN, Frascati (Italy); Capussela, T., E-mail: Tiziana.Capussela@na.infn.i [Dipartimento di Scienze Fisiche dell' Universita ' Federico II' , Napoli (Italy); Ceradini, F. [Dipartimento di Fisica dell' Universita ' Roma Tre' , Roma (Italy); INFN Sezione di Roma Tre, Roma (Italy); Ciambrone, P.; De Lucia, E. [Laboratori Nazionali di Frascati dell' INFN, Frascati (Italy); De Santis, A. [Dipartimento di Fisica dell' Universita ' La Sapienza' , Roma (Italy); INFN Sezione di ' La Sapienza' , Roma (Italy); De Simone, P. [Laboratori Nazionali di Frascati dell' INFN, Frascati (Italy); De Zorzi, G. [Dipartimento di Fisica dell' Universita ' La Sapienza' , Roma (Italy); INFN Sezione di ' La Sapienza' , Roma (Italy)

    2010-10-25

    We present a measurement of the slope parameter {alpha} for the {eta}{yields}3{pi}{sup 0} decay, with the KLOE experiment at the DA{Phi}NE {phi}-factory, based on a background free sample of {approx}17 million {eta} mesons produced in {phi} radiative decays. By fitting the event density in the Dalitz plot we determine {alpha}=-0.0301{+-}0.0035stat{sub -0.0035}{sup +0.0022}syst. The result is in agreement with recent measurements from hadro- and photo-production experiments.

  18. 2013 Australasian sky guide

    CERN Document Server

    Lomb, Nick

    2012-01-01

    Compact, easy to use and reliable, this popular guide contains everything you need to know about the southern night sky with monthly star maps, diagrams and details of all the year's exciting celestial events. Wherever you are in Australia or New Zealand, easy calculations allow you to determine when the Sun, Moon and planets will rise and set throughout the year. Also included is information on the latest astronomical findings from space probes and telescopes around the world. The Sky guide has been published annually by the Powerhouse Museum, Sydney, since 1991. It is recommended for photogr

  19. 2015 Australasian sky guide

    CERN Document Server

    Lomb, Nick

    2014-01-01

    Compact, easy to use and reliable, this popular guide has been providing star gazers with everything they need to know about the southern night sky for the past 25 years. The 2015 guide will celebrate this landmark with highlights from the past as well as monthly astronomy maps, viewing tips and highlights, and details of the year's exciting celestial events.Wherever you are in Australia or New Zealand, easy calculations allow you to estimate local rise and set times for the Sun, Moon and planets. The 2015 Australasian Sky Guide also provides information on the solar system, updated with the l

  20. Aerobic Glycolysis in the Frontal Cortex Correlates with Memory Performance in Wild-Type Mice But Not the APP/PS1 Mouse Model of Cerebral Amyloidosis.

    Science.gov (United States)

    Harris, Richard A; Tindale, Lauren; Lone, Asad; Singh, Olivia; Macauley, Shannon L; Stanley, Molly; Holtzman, David M; Bartha, Robert; Cumming, Robert C

    2016-02-10

    Aerobic glycolysis and lactate production in the brain plays a key role in memory, yet the role of this metabolism in the cognitive decline associated with Alzheimer's disease (AD) remains poorly understood. Here we examined the relationship between cerebral lactate levels and memory performance in an APP/PS1 mouse model of AD, which progressively accumulates amyloid-β. In vivo (1)H-magnetic resonance spectroscopy revealed an age-dependent decline in lactate levels within the frontal cortex of control mice, whereas lactate levels remained unaltered in APP/PS1 mice from 3 to 12 months of age. Analysis of hippocampal interstitial fluid by in vivo microdialysis revealed a significant elevation in lactate levels in APP/PS1 mice relative to control mice at 12 months of age. An age-dependent decline in the levels of key aerobic glycolysis enzymes and a concomitant increase in lactate transporter expression was detected in control mice. Increased expression of lactate-producing enzymes correlated with improved memory in control mice. Interestingly, in APP/PS1 mice the opposite effect was detected. In these mice, increased expression of lactate producing enzymes correlated with poorer memory performance. Immunofluorescent staining revealed localization of the aerobic glycolysis enzymes pyruvate dehydrogenase kinase and lactate dehydrogenase A within cortical and hippocampal neurons in control mice, as well as within astrocytes surrounding amyloid plaques in APP/PS1 mice. These observations collectively indicate that production of lactate, via aerobic glycolysis, is beneficial for memory function during normal aging. However, elevated lactate levels in APP/PS1 mice indicate perturbed lactate processing, a factor that may contribute to cognitive decline in AD. Lactate has recently emerged as a key metabolite necessary for memory consolidation. Lactate is the end product of aerobic glycolysis, a unique form of metabolism that occurs within certain regions of the brain. Here

  1. YXQN Reduces Alzheimer’s Disease-Like Pathology and Cognitive Decline in APPswePS1dE9 Transgenic Mice

    Directory of Open Access Journals (Sweden)

    Xiaowan Wang

    2017-05-01

    Full Text Available Alzheimer’s disease (AD is the world’s most common form of dementia, in which aggregation of amyloid-β (Aβ is the hallmark. Unfortunately, few medicines have succeeded to completely cure AD. Yangxue Qingnao (YXQN is a Chinese traditional medicine, and its pharmacological effect is improving cerebral blood flow. In this study, we firstly demonstrated that YXQN reduced AD-like pathology and cognitive impairment in APPswePS1dE9 (APP/PS1 mice with 2 months administration. Our data showed that YXQN substantially ameliorated behavioral defects in 10-month old APP/PS1 mice using Morris Water Maze and Y-maze tests, in which the cognitive ability of YXQN high-dose group approaches to wild type mice. Next, we focused on the brain pathological alterations in the YXQN group by three experiments, including thioflavin-S, congo-red, and Aβ-immunohistochemistry staining. The results demonstrated that the high-dose of YXQN dramatically suppressed amyloid plaques in the hippocampus and cortex of APP/PS1 mice, which showed a 47–72% reduction in plaque deposits, relative to the vehicle group. In addition, our data verified that YXQN decreased the cerebral amyloid load by attenuating β-secretase BACE1 and γ-secretase PS1 in the pathological processing of APP, and promoting the level of α-secretase ADAM10 in the physiological processing of APP to generate more sAPPα, which combats amyloidosis formation, and also carries out neurotropic and neuroprotective effect. Taken together, our results strongly suggest that YXQN could be a potential medicine for AD, and provide new evidence for further AD drug research and development.

  2. PS1-12sk IS A PECULIAR SUPERNOVA FROM A He-RICH PROGENITOR SYSTEM IN A BRIGHTEST CLUSTER GALAXY ENVIRONMENT

    International Nuclear Information System (INIS)

    Sanders, N. E.; Soderberg, A. M.; Foley, R. J.; Chornock, R.; Milisavljevic, D.; Margutti, R.; Drout, M. R.; Moe, M.; Berger, E.; Brown, W. R.; Lunnan, R.; Smartt, S. J.; Fraser, M.; Kotak, R.; Magill, L.; Smith, K. W.; Wright, D.; Huang, K.; Urata, Y.; Mulchaey, J. S.

    2013-01-01

    We report on our discovery and observations of the Pan-STARRS1 supernova (SN) PS1-12sk, a transient with properties that indicate atypical star formation in its host galaxy cluster or pose a challenge to popular progenitor system models for this class of explosion. The optical spectra of PS1-12sk classify it as a Type Ibn SN (SN Ibn; cf. SN 2006jc), dominated by intermediate-width (3 × 10 3 km s –1 ) and time variable He I emission. Our multi-wavelength monitoring establishes the rise time dt ∼ 9-23 days and shows an NUV-NIR spectral energy distribution with temperature ∼> 17 × 10 3 K and a peak magnitude of M z = –18.88 ± 0.02 mag. SN Ibn spectroscopic properties are commonly interpreted as the signature of a massive star (17-100 M ☉ ) explosion within an He-enriched circumstellar medium. However, unlike previous SNe Ibn, PS1-12sk is associated with an elliptical brightest cluster galaxy, CGCG 208–042 (z = 0.054) in cluster RXC J0844.9+4258. The expected probability of an event like PS1-12sk in such environments is low given the measured infrequency of core-collapse SNe in red-sequence galaxies compounded by the low volumetric rate of SN Ibn. Furthermore, we find no evidence of star formation at the explosion site to sensitive limits (Σ Hα ∼ –3 M ☉ yr –1 kpc –2 ). We therefore discuss white dwarf binary systems as a possible progenitor channel for SNe Ibn. We conclude that PS1-12sk represents either a fortuitous and statistically unlikely discovery, evidence for a top-heavy initial mass function in galaxy cluster cooling flow filaments, or the first clue suggesting an alternate progenitor channel for SNe Ibn.

  3. Sphingosine 1-phosphate (S1P)/S1P receptor 1 signaling regulates receptor activator of NF-κB ligand (RANKL) expression in rheumatoid arthritis

    International Nuclear Information System (INIS)

    Takeshita, Harunori; Kitano, Masayasu; Iwasaki, Tsuyoshi; Kitano, Sachie; Tsunemi, Sachi; Sato, Chieri; Sekiguchi, Masahiro; Azuma, Naoto; Miyazawa, Keiji; Hla, Timothy; Sano, Hajime

    2012-01-01

    Highlights: ► MH7A cells and CD4 + T cells expressed S1P1 and RANKL. ► S1P increased RANKL expression in MH7A cells and CD4 + T cells. ► The effect of S1P in MH7A cells was inhibited by specific Gi/Go inhibitors. -- Abstract: Sphingosine 1-phosphate (S1P)/S1P receptor 1 (S1P1) signaling plays an important role in synovial cell proliferation and inflammatory gene expression by rheumatoid arthritis (RA) synoviocytes. The purpose of this study is to clarify the role of S1P/S1P1 signaling in the expression of receptor activator of NF-κB ligand (RANKL) in RA synoviocytes and CD4 + T cells. We demonstrated MH7A cells, a human RA synovial cell line, and CD4 + T cells expressed S1P1 and RANKL. Surprisingly, S1P increased RANKL expression in MH7A cells and CD4 + T cells in a dose-dependent manner. Moreover, S1P enhanced RANKL expression induced by stimulation with TNF-α in MH7A cells and CD4 + T cells. These effects of S1P in MH7A cells were inhibited by pretreatment with PTX, a specific Gi/Go inhibitor. These findings suggest that S1P/S1P1 signaling may play an important role in RANKL expression by MH7A cells and CD4 + T cells. S1P/S1P1 signaling of RA synoviocytes is closely connected with synovial hyperplasia, inflammation, and RANKL-induced osteoclastogenesis in RA. Thus, regulation of S1P/S1P1 signaling may become a novel therapeutic target for RA.

  4. Sphingosine 1-phosphate (S1P)/S1P receptor 1 signaling regulates receptor activator of NF-{kappa}B ligand (RANKL) expression in rheumatoid arthritis

    Energy Technology Data Exchange (ETDEWEB)

    Takeshita, Harunori [Division of Rheumatology, Department of Internal Medicine, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501 (Japan); Kitano, Masayasu, E-mail: mkitano6@hyo-med.ac.jp [Division of Rheumatology, Department of Internal Medicine, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501 (Japan); Iwasaki, Tsuyoshi [Department of Pharmacy, Hyogo University of Health Sciences, 1-3-6 Minatojima Kobe, Hyogo 650-8530 (Japan); Kitano, Sachie; Tsunemi, Sachi; Sato, Chieri; Sekiguchi, Masahiro; Azuma, Naoto [Division of Rheumatology, Department of Internal Medicine, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501 (Japan); Miyazawa, Keiji [Discovery Research III, Research and Development, Kissei Pharmaceutical Company, 4365-1 Hodakakashiwara, Azumino, Nagano 399-8304 (Japan); Hla, Timothy [Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, 1300 York Avenue, Box 69, NY 10065 (United States); Sano, Hajime [Division of Rheumatology, Department of Internal Medicine, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501 (Japan)

    2012-03-09

    Highlights: Black-Right-Pointing-Pointer MH7A cells and CD4{sup +} T cells expressed S1P1 and RANKL. Black-Right-Pointing-Pointer S1P increased RANKL expression in MH7A cells and CD4{sup +} T cells. Black-Right-Pointing-Pointer The effect of S1P in MH7A cells was inhibited by specific Gi/Go inhibitors. -- Abstract: Sphingosine 1-phosphate (S1P)/S1P receptor 1 (S1P1) signaling plays an important role in synovial cell proliferation and inflammatory gene expression by rheumatoid arthritis (RA) synoviocytes. The purpose of this study is to clarify the role of S1P/S1P1 signaling in the expression of receptor activator of NF-{kappa}B ligand (RANKL) in RA synoviocytes and CD4{sup +} T cells. We demonstrated MH7A cells, a human RA synovial cell line, and CD4{sup +} T cells expressed S1P1 and RANKL. Surprisingly, S1P increased RANKL expression in MH7A cells and CD4{sup +} T cells in a dose-dependent manner. Moreover, S1P enhanced RANKL expression induced by stimulation with TNF-{alpha} in MH7A cells and CD4{sup +} T cells. These effects of S1P in MH7A cells were inhibited by pretreatment with PTX, a specific Gi/Go inhibitor. These findings suggest that S1P/S1P1 signaling may play an important role in RANKL expression by MH7A cells and CD4{sup +} T cells. S1P/S1P1 signaling of RA synoviocytes is closely connected with synovial hyperplasia, inflammation, and RANKL-induced osteoclastogenesis in RA. Thus, regulation of S1P/S1P1 signaling may become a novel therapeutic target for RA.

  5. The observer's sky atlas

    CERN Document Server

    Karkoschka, E

    2007-01-01

    This title includes a short introduction to observing, a thorough description of the star charts and tables, a glossary and much more. It is perfect for both the beginner and seasoned observer. It is fully revised edition of a best-selling and highly-praised sky atlas.

  6. The Big Sky inside

    Science.gov (United States)

    Adams, Earle; Ward, Tony J.; Vanek, Diana; Marra, Nancy; Hester, Carolyn; Knuth, Randy; Spangler, Todd; Jones, David; Henthorn, Melissa; Hammill, Brock; Smith, Paul; Salisbury, Rob; Reckin, Gene; Boulafentis, Johna

    2009-01-01

    The University of Montana (UM)-Missoula has implemented a problem-based program in which students perform scientific research focused on indoor air pollution. The Air Toxics Under the Big Sky program (Jones et al. 2007; Adams et al. 2008; Ward et al. 2008) provides a community-based framework for understanding the complex relationship between poor…

  7. A night sky model.

    Science.gov (United States)

    Erpylev, N. P.; Smirnov, M. A.; Bagrov, A. V.

    A night sky model is proposed. It includes different components of light polution, such as solar twilight, moon scattered light, zodiacal light, Milky Way, air glow and artificial light pollution. The model is designed for calculating the efficiency of astronomical installations.

  8. Nuclear 82-kDa choline acetyltransferase decreases amyloidogenic APP metabolism in neurons from APP/PS1 transgenic mice.

    Science.gov (United States)

    Albers, Shawn; Inthathirath, Fatima; Gill, Sandeep K; Winick-Ng, Warren; Jaworski, Ewa; Wong, Daisy Y L; Gros, Robert; Rylett, R Jane

    2014-09-01

    Alzheimer disease (AD) is associated with increased amyloidogenic processing of amyloid precursor protein (APP) to β-amyloid peptides (Aβ), cholinergic neuron loss with decreased choline acetyltransferase (ChAT) activity, and cognitive dysfunction. Both 69-kDa ChAT and 82-kDa ChAT are expressed in cholinergic neurons in human brain and spinal cord with 82-kDa ChAT localized predominantly to neuronal nuclei, suggesting potential alternative functional roles for the enzyme. By gene microarray analysis, we found that 82-kDa ChAT-expressing IMR32 neural cells have altered expression of genes involved in diverse cellular functions. Importantly, genes for several proteins that regulate APP processing along amyloidogenic and non-amyloidogenic pathways are differentially expressed in 82-kDa ChAT-containing cells. The predicted net effect based on observed changes in expression patterns of these genes would be decreased amyloidogenic APP processing with decreased Aβ production. This functional outcome was verified experimentally as a significant decrease in BACE1 protein levels and activity and a concomitant reduction in the release of endogenous Aβ1-42 from neurons cultured from brains of AD-model APP/PS1 transgenic mice. The expression of 82-kDa ChAT in neurons increased levels of GGA3, which is involved in trafficking BACE1 to lysosomes for degradation. shRNA-induced decreases in GGA3 protein levels attenuated the 82-kDa ChAT-mediated decreases in BACE1 protein and activity and Aβ1-42 release. Evidence that 82-kDa ChAT can enhance GGA3 gene expression is shown by enhanced GGA3 gene promoter activity in SN56 neural cells expressing this ChAT protein. These studies indicate a novel relationship between cholinergic neurons and APP processing, with 82-kDa ChAT acting as a negative regulator of Aβ production. This decreased formation of Aβ could result in protection for cholinergic neurons, as well as protection of other cells in the vicinity that are sensitive to

  9. Infrared Sky Surveys

    Science.gov (United States)

    Price, Stephan D.

    2009-02-01

    A retrospective is given on infrared sky surveys from Thomas Edison’s proposal in the late 1870s to IRAS, the first sensitive mid- to far-infrared all-sky survey, and the mid-1990s experiments that filled in the IRAS deficiencies. The emerging technology for space-based surveys is highlighted, as is the prominent role the US Defense Department, particularly the Air Force, played in developing and applying detector and cryogenic sensor advances to early mid-infrared probe-rocket and satellite-based surveys. This technology was transitioned to the infrared astronomical community in relatively short order and was essential to the success of IRAS, COBE and ISO. Mention is made of several of the little known early observational programs that were superseded by more successful efforts.

  10. The VLA Sky Survey

    Science.gov (United States)

    Lacy, Mark; VLASS Survey Team, VLASS Survey Science Group

    2018-01-01

    The VLA Sky Survey (VLASS), which began in September 2017, is a seven year project to image the entire sky north of Declination -40 degrees in three epochs. The survey is being carried out in I,Q and U polarization at a frequency of 2-4GHz, and a resolution of 2.5 arcseconds, with each epoch being separated by 32 months. Raw data from the survey, along with basic "quicklook" images are made freely available shortly after observation. Within a few months, NRAO will begin making available further basic data products, including refined images and source lists. In this talk I shall describe the science goals and methodology of the survey, the current survey status, and some early results, along with plans for collaborations with external groups to produce enhanced, high level data products.

  11. Tetrahydroxystilbene glucoside modulates amyloid precursor protein processing via activation of AKT-GSK3β pathway in cells and in APP/PS1 transgenic mice.

    Science.gov (United States)

    Yin, Xiaomin; Chen, Chen; Xu, Ting; Li, Lin; Zhang, Lan

    2018-01-01

    Alternative splicing of amyloid precursor protein (APP) exon 7 generates the isoforms containing a Kunitz protease inhibitor (KPI) domain. APP-KPI levels in the brain are correlated with amyloid beta (Aβ) production. Here, we determined the effect of Tetrahydroxystilbene glucoside (TSG) on the AKT-GSK3β pathway. We found GSK3β increased APP-KPI inclusion level and interacted with the splicing factor ASF. TSG was intragastrically administered to 5-month-old APP/PS1 transgenic mice for 12 months. We found that the activated the AKT-GSK3β signaling pathway suppressed APP-KPI inclusion. Moreover, TSG treatment attenuated amyloid deposition in APP/PS1 mice. This study demonstrates the neuroprotective effect of TSG on APP expression, suggesting that TSG may be beneficial for AD prevention and treatment. Copyright © 2017 Elsevier Inc. All rights reserved.

  12. Sacred Sky and Cyberspace

    Science.gov (United States)

    Clynes, F.

    2011-06-01

    The concept of the sacred world beyond the stars found expression in the works of Plato, into Gnosticism and was incorporated into Christianity where medieval images of the cosmos pictured the heavenly domain as beyond the stars. Today cyberspace literature abounds with descriptions of a transmundane space, a great Beyond. This talk looks at current views of cyberspace and asks if they are a re-packaging of the age-old concept of a sacred sky in a secular and technological format?

  13. 2012 Australasian sky guide

    CERN Document Server

    Lomb, Nick

    2011-01-01

    Compact, easy to use and reliable, this popular guide contains everything you need to know about the southern night sky with monthly star maps, diagrams and details of all the year's exciting celestial events. Wherever you are in Australia or New Zealand, easy calculations allow you to determine when the Sun, Moon and planets will rise and set throughout the year. Also included is information on the latest astronomical findings from space probes and telescopes around the world.

  14. The Sky at Night

    CERN Document Server

    Moore, Patrick

    2010-01-01

    For more than 50 years now Sir Patrick Moore has presented the BBC Television series Sky at Night; not a month has been missed – a record for any television series, and a record which may never be broken. Every three years or so a book is published covering the main events in both astronomy and space research. This is the 13th volume, not only a record of the programmes but also of the great advances and discoveries during the period covered - eclipses, comets, and the strange chemical lakes of Titan, for instance, but also anniversaries such as the fifteenth “birthday” of the Hubble Space Telescope, and not forgetting the programme celebrating the Sky at Night’s 50th year, attended by astronaut Piers Sellars and many others who appeared on the programme over the years. All the chapters are self-contained, and fully illustrated. In this new Sky at Night book you will find much to entertain you. It will appeal to amateurs and professionals alike.

  15. Plaque deposition dependent decrease in 5-HT2A serotonin receptor in AbetaPPswe/PS1dE9 amyloid overexpressing mice

    DEFF Research Database (Denmark)

    Holm, Peter; Ettrup, Anders; Klein, Anders B

    2010-01-01

    -HT2A receptor regulation in double transgenic AbetaPPswe/PS1dE9 mice which display excess production of Abeta and age-dependent increase in amyloid plaques. Three different age-groups, 4-month-old, 8- month-old, and 11-month-old were included in the study. [3H]-MDL100907, [3H]-escitalopram, and [11C...

  16. Altered cell cycle-related gene expression in brain and lymphocytes from a transgenic mouse model of Alzheimer's disease [amyloid precursor protein/presenilin 1 (PS1)].

    Science.gov (United States)

    Esteras, Noemí; Bartolomé, Fernando; Alquézar, Carolina; Antequera, Desireé; Muñoz, Úrsula; Carro, Eva; Martín-Requero, Ángeles

    2012-09-01

    Cumulative evidence indicates that aberrant re-expression of many cell cycle-related proteins and inappropriate neuronal cell cycle control are critical events in Alzheimer's disease (AD) pathogenesis. Evidence of cell cycle activation in post-mitotic neurons has also been observed in murine models of AD, despite the fact that most of these mice do not show massive loss of neuronal bodies. Dysfunction of the cell cycle appears to affect cells other than neurons, as peripheral cells, such as lymphocytes and fibroblasts from patients with AD, show an altered response to mitogenic stimulation. We sought to determine whether cell cycle disturbances are present simultaneously in both brain and peripheral cells from the amyloid precursor protein (APP)/presenilin 1 (PS1) mouse model of AD, in order to validate the use of peripheral cells from patients not only to study cell cycle abnormalities as a pathogenic feature of AD, but also as a means to test novel therapeutic approaches. By using cell cycle pathway-specific RT(2)Profiler™ PCR Arrays, we detected changes in a number of cell cycle-related genes in brain as well as in lymphocytes from APP/PS1 mice. Moreover, we found enhanced 5'-bromo-2'-deoxyuridine incorporation into DNA in lymphocytes from APP/PS1 mice, and increased expression of the cell proliferation marker proliferating cell nuclear antigen (PCNA), and the cyclin-dependent kinase (CDK) inhibitor Cdkn2a, as detected by immunohistochemistry in cortical neurons of the APP/PS1 mice. Taken together, the cell cycle-related changes in brain and blood cells reported here support the mitosis failure hypothesis in AD and validate the use of peripheral cells as surrogate tissue to study the molecular basis of AD pathogenesis. © 2012 The Authors. European Journal of Neuroscience © 2012 Federation of European Neuroscience Societies and Blackwell Publishing Ltd.

  17. Noggin and BMP4 co-modulate adult hippocampal neurogenesis in the APPswe/PS1ΔE9 transgenic mouse model of Alzheimer's disease

    International Nuclear Information System (INIS)

    Tang, Jun; Song, Min; Wang, Yanyan; Fan, Xiaotang; Xu, Haiwei; Bai, Yun

    2009-01-01

    In addition to the subventricular zone, the dentate gyrus of the hippocampus is one of the few brain regions in which neurogenesis continues into adulthood. Perturbation of neurogenesis can alter hippocampal function, and previous studies have shown that neurogenesis is dysregulated in Alzheimer disease (AD) brain. Bone morphogenetic protein-4 (BMP4) and its antagonist Noggin have been shown to play important roles both in embryonic development and in the adult nervous system, and may regulate hippocampal neurogenesis. Previous data indicated that increased expression of BMP4 mRNA within the dentate gyrus might contribute to decreased hippocampal cell proliferation in the APP swe /PS1 ΔE9 mouse AD model. However, it is not known whether the BMP antagonist Noggin contributes to the regulation of neurogenesis. We therefore studied the relative expression levels and localization of BMP4 and its antagonist Noggin in the dentate gyrus and whether these correlated with changes in neurogenesis in 6-12 mo old APP swe /PS1 ΔE9 transgenic mice. Bromodeoxyuridine (BrdU) was used to label proliferative cells. We report that decreased neurogenesis in the APP/PS1 transgenic mice was accompanied by increased expression of BMP4 and decreased expression of Noggin at both the mRNA and protein levels; statistical analysis showed that the number of proliferative cells at different ages correlated positively with Noggin expression and negatively with BMP4 expression. Intraventricular administration of a chimeric Noggin/Fc protein was used to block the action of endogenous BMP4; this resulted in a significant increase in the number of BrdU-labeled cells in dentate gyrus subgranular zone and hilus in APP/PS1 mice. These results suggest that BMP4 and Noggin co-modulate neurogenesis.

  18. ApoA-I/SR-BI modulates S1P/S1PR2-mediated inflammation through the PI3K/Akt signaling pathway in HUVECs.

    Science.gov (United States)

    Ren, Kun; Lu, Yan-Ju; Mo, Zhong-Cheng; -Liu, Xing; Tang, Zhen-Li; Jiang, Yue; Peng, Xiao-Shan; Li, Li; Zhang, Qing-Hai; Yi, Guang-Hui

    2017-05-01

    Endothelial dysfunction plays a vital role during the initial stage of atherosclerosis. Oxidized low-density lipoprotein (ox-LDL) induces vascular endothelial injury and vessel wall inflammation. Sphingosine-1-phosphate (S1P) exerts numerous vasoprotective effects by binding to diverse S1P receptors (S1PRs; S1PR1-5). A number of studies have shown that in endothelial cells (ECs), S1PR2 acts as a pro-atherosclerotic mediator by stimulating vessel wall inflammation through the phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway. Scavenger receptor class B member I (SR-BI), a high-affinity receptor for apolipoprotein A-I (apoA-I)/high-density lipoprotein (HDL), inhibits nuclear factor-κB (NF-κB) translocation and decreases the plasma levels of inflammatory mediators via the PI3K/Akt pathway. We hypothesized that the inflammatory effects of S1P/S1PR2 on ECs may be regulated by apoA-I/SR-BI. The results showed that ox-LDL, a pro-inflammatory factor, augmented the S1PR2 level in human umbilical vein endothelial cells (HUVECs) in a dose- and time-dependent manner. In addition, S1P/S1PR2 signaling influenced the levels of inflammatory factors, including tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and IL-10, aggravating inflammation in HUVECs. Moreover, the pro-inflammatory effects induced by S1P/S1PR2 were attenuated by SR-BI overexpression and enhanced by an SR-BI inhibitor, BLT-1. Further experiments showed that the PI3K/Akt signaling pathway was involved in this process. Taken together, these results demonstrate that apoA-I/SR-BI negatively regulates S1P/S1PR2-mediated inflammation in HUVECs by activating the PI3K/Akt signaling pathway.

  19. Increased Alzheimer's disease-like pathology in the APP/ PS1ΔE9 mouse model lacking Nrf2 through modulation of autophagy.

    Science.gov (United States)

    Joshi, Gururaj; Gan, Kok Ann; Johnson, Delinda A; Johnson, Jeffrey A

    2015-02-01

    The presence of senile plaques is one of the major pathologic hallmarks of the brain with Alzheimer's disease (AD). The plaques predominantly contain insoluble amyloid β-peptide, a cleavage product of the larger amyloid precursor protein (APP). Two enzymes, named β and γ secretase, generate the neurotoxic amyloid-β peptide from APP. Mature APP is also turned over endogenously by autophagy, more specifically by the endosomal-lysosomal pathway. A defective lysosomal system is known to be pathogenic in AD. Modulation of NF-E2 related factor 2 (Nrf2) has been shown in several neurodegenerative disorders, and Nrf2 has become a potential therapeutic target for various neurodegenerative disorders, including AD, Parkinson's disease, and amyotrophic lateral sclerosis. In the current study, we explored the effect of genetic ablation of Nrf2 on APP/Aβ processing and/or aggregation as well as changes in autophagic dysfunction in APP/PS1 mice. There was a significant increase in inflammatory response in APP/PS1 mice lacking Nrf2. This was accompanied by increased intracellular levels of APP, Aβ (1-42), and Aβ (1-40), without a change total full-length APP. There was a shift of APP and Aβ into the insoluble fraction, as well as increased poly-ubiquitin conjugated proteins in mice lacking Nrf2. APP/PS1-mediated autophagic dysfunction is also enhanced in Nrf2-deficient mice. Finally, neurons in the APP/PS1/Nrf2-/- mice had increased accumulation of multivesicular bodies, endosomes, and lysosomes. These outcomes provide a better understanding of the role of Nrf2 in modulating autophagy in an AD mouse model and may help design better Nrf2 targeted therapeutics that could be efficacious in the treatment of AD. Published by Elsevier Inc.

  20. Infection of Parainfluenza type 3 (PI-3 as one of the causative agent of pneumonia in sheep and goats

    Directory of Open Access Journals (Sweden)

    Indrawati Sendow

    2002-03-01

    Full Text Available Serological survey was conducted to obtain the prevalence of Parainfluenza type 3 (PI-3 reactor as one of the causative agent of pneumonia in sheep and goats in abatoir at Jakarta and some small holder farms in Indonesia. Serological test using serum neutralization from 724 goat sera and 109 sheep sera indicated that only 1% of goats were serologically reactors and none of sheep sera had antibodies against PI-3 virus. Isolation of the virus from 56 bronchus and trachea swab and 345 lungs indicated that only one sampel from lung showed cythopathic effect (CPE in Madin Darby Bovine Kidney (MDBK cell lines identification of the virus using serum neutralization test indicated that the virus neutralized reference PI-3 antisera. The isolate came from one lung (7% of 24 that showed histopathologically pneumonia intertitialis that usually caused by viral infection.

  1. Citalopram restores short-term memory deficit and non-cognitive behaviors in APP/PS1 mice while halting the advance of Alzheimer's disease-like pathology.

    Science.gov (United States)

    Zhang, Qin; Yang, Chen; Liu, Tianyao; Liu, Liang; Li, Fen; Cai, Yulong; Lv, Keyi; Li, Xin; Gao, Junwei; Sun, Dayu; Xu, Haiwei; Yang, Qingwu; Fan, Xiaotang

    2018-03-15

    Alzheimer's disease (AD) is the most common cause of dementia. In addition to cognitive impairments, deficits in non-cognitive behaviors are also common neurological sequelae in AD. Here, we show that complex behavioral deficits in 7-month-old APPswe/PSEN1dE9 (APP/PS1) mice include impairments in object recognition, deficient social interaction, increased depression and buried marbles. Citalopram, one of the selective serotonin reuptake inhibitors (SSRIs), ameliorated the amyloid deposition in AD patients and transgenic animal models. After treatment for 4 weeks, citalopram rescued the deficits in short-term memory, sociability and depression in these mice. Further immunohistochemical analysis showed chronic citalopram treatment significantly attenuated β-amyloid deposition and microglial activation in the brains of APP/PS1 mice as demonstrated previously. Parvalbumin (PV) interneurons, which are the primary cellular subtype of GABAergic neurons and considered indispensable for short-term memory and social interaction, also contributed to the progress of depression. Additionally, we found the citalopram could significantly increase the PV-positive neurons in the cortex of APP/PS1 mice without alteration in the hippocampus, which might contribute to the improvement of behavioral performance. Our findings suggest that citalopram might be a potential candidate for the early treatment of AD. Copyright © 2017 Elsevier Ltd. All rights reserved.

  2. Transplantation of Human Menstrual Blood-Derived Mesenchymal Stem Cells Alleviates Alzheimer’s Disease-Like Pathology in APP/PS1 Transgenic Mice

    Directory of Open Access Journals (Sweden)

    Yongjia Zhao

    2018-04-01

    Full Text Available Extracellular β-amyloid (Aβ plaques and neurofibrillary tangles (NFTs are the pathological hallmarks of Alzheimer’s disease (AD. Mesenchymal stem cells (MSCs have shown therapeutic efficacy in many neurodegenerative diseases, including AD. Human menstrual blood-derived stem cells (MenSCs are a novel source of MSCs advantageous for their higher proliferation rate and because they are easy to obtain without ethical concerns. Although MenSCs have exhibited therapeutic efficacy in some diseases, their effects on AD remain elusive. In the present study, we showed that intracerebral transplantation of MenSCs dramatically improved the spatial learning and memory of APP/PS1 mice. In addition, MenSCs significantly ameliorated amyloid plaques and reduced tau hyperphosphorylation in APP/PS1 mice. Remarkably, we also found that intracerebral transplantation of MenSCs markedly increased several Aβ degrading enzymes and modulated a panel of proinflammatory cytokines associated with an altered microglial phenotype, suggesting an Aβ degrading and anti-inflammatory impact of MenSCs in the brains of APP/PS1 mice. In conclusion, these findings suggest that MenSCs are a promising therapeutic candidate for AD.

  3. Immunocytochemical Characterization of Alzheimer Disease Hallmarks in APP/PS1 Transgenic Mice Treated with a New Anti-Amyloid-β Vaccine

    Directory of Open Access Journals (Sweden)

    Iván Carrera

    2013-01-01

    Full Text Available APP/PS1 double-transgenic mouse models of Alzheimer’s disease (AD, which overexpress mutated forms of the gene for human amyloid precursor protein (APP and presenilin 1 (PS1, have provided robust neuropathological hallmarks of AD-like pattern at early ages. This study characterizes immunocytochemical patterns of AD mouse brain as a model for human AD treated with the EB101 vaccine. In this novel vaccine, a new approach has been taken to circumvent past failures by judiciously selecting an adjuvant consisting of a physiological matrix embedded in liposomes, composed of naturally occurring phospholipids (phosphatidylcholine, phosphatidylglycerol, and cholesterol. Our findings showed that administration of amyloid-β1−42 (Aβ and sphingosine-1-phosphate emulsified in liposome complex (EB101 to APP/PS1 mice before onset of Aβ deposition (7 weeks of age and/or at an older age (35 weeks of age is effective in halting the progression and clearing the AD-like neuropathological hallmarks. Passive immunization with EB101 did not activate inflammatory responses from the immune system and astrocytes. Consistent with a decreased inflammatory background, the basal immunological interaction between the T cells and the affected areas (hippocampus in the brain of treated mice was notably reduced. These results demonstrate that immunization with EB101 vaccine prevents and attenuates AD neuropathology in this type of double-transgenic mice.

  4. Utilization of APPswe/PS1dE9 Transgenic Mice in Research of Alzheimer's Disease: Focus on Gene Therapy and Cell-Based Therapy Applications

    Directory of Open Access Journals (Sweden)

    Tarja Malm

    2011-01-01

    Full Text Available One of the most extensively used transgenic mouse model of Alzheimer’s disease (AD is APPswe/PS1dE9 mice, which over express the Swedish mutation of APP together with PS1 deleted in exon 9. These mice show increase in parenchymal Aβ load with Aβ plaques starting from the age of four months, glial activation, and deficits in cognitive functions at the age of 6 months demonstrated by radial arm water maze and 12-13 months seen with Morris Water Maze test. As gene transfer technology allows the delivery of DNA into target cells to achieve the expression of a protective or therapeutic protein, and stem cell transplantation may create an environment supporting neuronal functions and clearing Aβ plaques, these therapeutic approaches alone or in combination represent potential therapeutic strategies that need to be tested in relevant animal models before testing in clinics. Here we review the current utilization of APPswe/PS1dE9 mice in testing gene transfer and cell transplantation aimed at improving the protection of the neurons against Aβ toxicity and also reducing the brain levels of Aβ. Both gene therapy and cell based therapy may be feasible therapeutic approaches for human AD.

  5. PS1/γ-Secretase-Mediated Cadherin Cleavage Induces β-Catenin Nuclear Translocation and Osteogenic Differentiation of Human Bone Marrow Stromal Cells

    Directory of Open Access Journals (Sweden)

    Danielle C. Bonfim

    2016-01-01

    Full Text Available Bone marrow stromal cells (BMSCs are considered a promising tool for bone bioengineering. However, the mechanisms controlling osteoblastic commitment are still unclear. Osteogenic differentiation of BMSCs requires the activation of β-catenin signaling, classically known to be regulated by the canonical Wnt pathway. However, BMSCs treatment with canonical Wnts in vitro does not always result in osteogenic differentiation and evidence indicates that a more complex signaling pathway, involving cadherins, would be required to induce β-catenin signaling in these cells. Here we showed that Wnt3a alone did not induce TCF activation in BMSCs, maintaining the cells at a proliferative state. On the other hand, we verified that, upon BMSCs osteoinduction with dexamethasone, cadherins were cleaved by the PS1/γ-secretase complex at the plasma membrane, and this event was associated with an enhanced β-catenin translocation to the nucleus and signaling. When PS1/γ-secretase activity was inhibited, the osteogenic process was impaired. Altogether, we provide evidence that PS1/γ-secretase-mediated cadherin cleavage has as an important role in controlling β-catenin signaling during the onset of BMSCs osteogenic differentiation, as part of a complex signaling pathway responsible for cell fate decision. A comprehensive map of these pathways might contribute to the development of strategies to improve bone repair.

  6. PS1-12sk IS A PECULIAR SUPERNOVA FROM A He-RICH PROGENITOR SYSTEM IN A BRIGHTEST CLUSTER GALAXY ENVIRONMENT

    Energy Technology Data Exchange (ETDEWEB)

    Sanders, N. E.; Soderberg, A. M.; Foley, R. J.; Chornock, R.; Milisavljevic, D.; Margutti, R.; Drout, M. R.; Moe, M.; Berger, E.; Brown, W. R.; Lunnan, R. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Smartt, S. J.; Fraser, M.; Kotak, R.; Magill, L.; Smith, K. W.; Wright, D. [Astrophysics Research Centre, School of Maths and Physics, Queens University, Belfast BT7 1NN (United Kingdom); Huang, K. [Academia Sinica Institute of Astronomy and Astrophysics, Taipei 106, Taiwan (China); Urata, Y. [Institute of Astronomy, National Central University, Chung-Li 32054, Taiwan (China); Mulchaey, J. S., E-mail: nsanders@cfa.harvard.edu [Carnegie Observatories, 813 Santa Barbara Street, Pasadena, CA 91101 (United States); and others

    2013-05-20

    We report on our discovery and observations of the Pan-STARRS1 supernova (SN) PS1-12sk, a transient with properties that indicate atypical star formation in its host galaxy cluster or pose a challenge to popular progenitor system models for this class of explosion. The optical spectra of PS1-12sk classify it as a Type Ibn SN (SN Ibn; cf. SN 2006jc), dominated by intermediate-width (3 Multiplication-Sign 10{sup 3} km s{sup -1}) and time variable He I emission. Our multi-wavelength monitoring establishes the rise time dt {approx} 9-23 days and shows an NUV-NIR spectral energy distribution with temperature {approx}> 17 Multiplication-Sign 10{sup 3} K and a peak magnitude of M{sub z} = -18.88 {+-} 0.02 mag. SN Ibn spectroscopic properties are commonly interpreted as the signature of a massive star (17-100 M{sub Sun }) explosion within an He-enriched circumstellar medium. However, unlike previous SNe Ibn, PS1-12sk is associated with an elliptical brightest cluster galaxy, CGCG 208-042 (z = 0.054) in cluster RXC J0844.9+4258. The expected probability of an event like PS1-12sk in such environments is low given the measured infrequency of core-collapse SNe in red-sequence galaxies compounded by the low volumetric rate of SN Ibn. Furthermore, we find no evidence of star formation at the explosion site to sensitive limits ({Sigma}{sub H{alpha}} {approx}< 2 Multiplication-Sign 10{sup -3} M{sub Sun} yr{sup -1} kpc{sup -2}). We therefore discuss white dwarf binary systems as a possible progenitor channel for SNe Ibn. We conclude that PS1-12sk represents either a fortuitous and statistically unlikely discovery, evidence for a top-heavy initial mass function in galaxy cluster cooling flow filaments, or the first clue suggesting an alternate progenitor channel for SNe Ibn.

  7. Effects of Specific Multi-Nutrient Enriched Diets on Cerebral Metabolism, Cognition and Neuropathology in AβPPswe-PS1dE9 Mice

    Science.gov (United States)

    Jansen, Diane; Zerbi, Valerio; Arnoldussen, Ilse A. C.; Wiesmann, Maximilian; Rijpma, Anne; Fang, Xiaotian T.; Dederen, Pieter J.; Mutsaers, Martina P. C.; Broersen, Laus M.; Lütjohann, Dieter; Miller, Malgorzata; Joosten, Leo A. B.; Heerschap, Arend; Kiliaan, Amanda J.

    2013-01-01

    Recent studies have focused on the use of multi-nutrient dietary interventions in search of alternatives for the treatment and prevention of Alzheimer's disease (AD). In this study we investigated to which extent long-term consumption of two specific multi-nutrient diets can modulate AD-related etiopathogenic mechanisms and behavior in 11-12-month-old AβPPswe-PS1dE9 mice. Starting from 2 months of age, male AβPP-PS1 mice and wild-type littermates were fed either a control diet, the DHA+EPA+UMP (DEU) diet enriched with uridine monophosphate (UMP) and the omega-3 fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), or the Fortasyn® Connect (FC) diet enriched with the DEU diet plus phospholipids, choline, folic acid, vitamins and antioxidants. We performed behavioral testing, proton magnetic resonance spectroscopy, immunohistochemistry, biochemical analyses and quantitative real-time PCR to gain a better understanding of the potential mechanisms by which these multi-nutrient diets exert protective properties against AD. Our results show that both diets were equally effective in changing brain fatty acid and cholesterol profiles. However, the diets differentially affected AD-related pathologies and behavioral measures, suggesting that the effectiveness of specific nutrients may depend on the dietary context in which they are provided. The FC diet was more effective than the DEU diet in counteracting neurodegenerative aspects of AD and enhancing processes involved in neuronal maintenance and repair. Both diets elevated interleukin-1β mRNA levels in AβPP-PS1 and wild-type mice. The FC diet additionally restored neurogenesis in AβPP-PS1 mice, decreased hippocampal levels of unbound choline-containing compounds in wild-type and AβPP-PS1 animals, suggesting diminished membrane turnover, and decreased anxiety-related behavior in the open field behavior. In conclusion, the current data indicate that specific multi-nutrient diets can influence AD

  8. Effects of specific multi-nutrient enriched diets on cerebral metabolism, cognition and neuropathology in AβPPswe-PS1dE9 mice.

    Directory of Open Access Journals (Sweden)

    Diane Jansen

    Full Text Available Recent studies have focused on the use of multi-nutrient dietary interventions in search of alternatives for the treatment and prevention of Alzheimer's disease (AD. In this study we investigated to which extent long-term consumption of two specific multi-nutrient diets can modulate AD-related etiopathogenic mechanisms and behavior in 11-12-month-old AβPPswe-PS1dE9 mice. Starting from 2 months of age, male AβPP-PS1 mice and wild-type littermates were fed either a control diet, the DHA+EPA+UMP (DEU diet enriched with uridine monophosphate (UMP and the omega-3 fatty acids docosahexaenoic acid (DHA and eicosapentaenoic acid (EPA, or the Fortasyn® Connect (FC diet enriched with the DEU diet plus phospholipids, choline, folic acid, vitamins and antioxidants. We performed behavioral testing, proton magnetic resonance spectroscopy, immunohistochemistry, biochemical analyses and quantitative real-time PCR to gain a better understanding of the potential mechanisms by which these multi-nutrient diets exert protective properties against AD. Our results show that both diets were equally effective in changing brain fatty acid and cholesterol profiles. However, the diets differentially affected AD-related pathologies and behavioral measures, suggesting that the effectiveness of specific nutrients may depend on the dietary context in which they are provided. The FC diet was more effective than the DEU diet in counteracting neurodegenerative aspects of AD and enhancing processes involved in neuronal maintenance and repair. Both diets elevated interleukin-1β mRNA levels in AβPP-PS1 and wild-type mice. The FC diet additionally restored neurogenesis in AβPP-PS1 mice, decreased hippocampal levels of unbound choline-containing compounds in wild-type and AβPP-PS1 animals, suggesting diminished membrane turnover, and decreased anxiety-related behavior in the open field behavior. In conclusion, the current data indicate that specific multi-nutrient diets can

  9. X-ray sky

    International Nuclear Information System (INIS)

    Gruen, M.; Koubsky, P.

    1977-01-01

    The history is described of the discoveries of X-ray sources in the sky. The individual X-ray detectors are described in more detail, i.e., gas counters, scintillation detectors, semiconductor detectors, and the principles of X-ray spectrometry and of radiation collimation aimed at increased resolution are discussed. Currently, over 200 celestial X-ray sources are known. Some were identified as nebulae, in some pulsations were found or the source was identified as a binary star. X-ray bursts of novae were also observed. The X-ray radiation is briefly mentioned of spherical star clusters and of extragalactic X-ray sources. (Oy)

  10. Between Earth and Sky

    DEFF Research Database (Denmark)

    Carter, Adrian

    2009-01-01

    to rescue architecture from the sterile impasse of late-modernism. In his works the basic elements of lived space become present: the earth, the sky and the `between` of human existence." Jørn Utzon's architecture ranges from the modest to the monumental; from the Kingo courtyard houses, the finest...... of form, material and function, motivated by social values. To this essentially regional response, Utzon combines a fascination for the architectural legacies of foreign cultures. These influences include the architecture of the ancient Mayan civilisation, as well as the Islamic world, China and Japan...

  11. Sun, Earth and Sky

    CERN Document Server

    Lang, Kenneth R

    2006-01-01

    This Second Edition of Sun, Earth and Sky updates the popular text by providing comprehensive accounts of the most recent discoveries made by five modern solar spacecraft during the past decade. Their instruments have used sound waves to peer deep into the Sun’s inner regions and measure the temperature of its central nuclear reactor, and extended our gaze far from the visible Sun to record energetic outbursts that threaten Earth. Breakthrough observations with the underground Sudbury Neutrino Observatory are also included, which explain the new physics of ghostly neutrinos and solve the problematic mismatch between the predicted and observed amounts of solar neutrinos. This new edition of Sun, Earth and Sky also describes our recent understanding of how the Sun’s outer atmosphere is heated to a million degrees, and just where the Sun’s continuous winds come from. As humans we are more intimately linked with our life-sustaining Sun than with any other astronomical object, and the new edition therefore p...

  12. The Rainbow Sky

    CERN Document Server

    Buick, Tony

    2010-01-01

    The world is full of color, from the blue ocean and the yellow daffodils and sunflowers in green carpeted meadows to the majestic purple mountains in the distance and brightly hued coral reefs off the edges of tropical coasts. But what is color, exactly? Why do we see things in different colors? Do we all see the same colors? Like the surface of our planet, the sky above us offers us an endless palette of color, a visual feast for the eyes. Besides atmospheric phenomena such as sunsets and rainbows, there are the many varied worlds of the Solar System, which we can spy through our telescopes, with their subtle colorings of beige and blue and green. Faraway star systems have suns that come in shades ranging from red and yellow to blue and white. Scientists even often use "false colors" to enhance the features of images they take of structures, such as the rings of Saturn and Jupiter’s clouds. This book, with its clear explanations of what makes the sky such a colorful place and in its great wealth of picture...

  13. The Other Dark Sky

    Science.gov (United States)

    Pazmino, John

    In previous demonstrations of New York's elimination of luminous graffiti from its skies, I focused attention on large-scale projects in the showcase districts of Manhattan. Although these works earned passionate respect in the dark sky movement, they by the same token were disheartening. New York was in some quarters of the movement regarded more as an unachievable Shangri-La than as a role model to emulate. This presentation focuses on scenes of light abatement efforts in parts of New York which resemble other towns in scale and density. I photographed these scenes along a certain bus route in Brooklyn on my way home from work during October 2001. This route circulates through various "bedroom communities," each similar to a mid-size to large town elsewhere in the United States. The sujbects included individual structures - stores, banks, schools - and streetscapes mimicking downtowns. The latter protrayed a mix of atrocious and excellent lighting practice, being that these streets are in transition by the routine process of replacement and renovation. The fixtures used - box lamps, fluted or Fresnel globes, subdued headsigns, indirect lighting - are casually obtainable by property managers at local outlets for lighting apparatus. They are routinely offered to the property managers by storefront designers, security services, contractors, and the community improvement or betterment councils.

  14. Diamonds in the Sky

    Science.gov (United States)

    Brotherton, M.

    2004-12-01

    My first science fiction novel, Star Dragon, just recently available in paperback from Tor, features a voyage to the cataclysmic variable star system SS Cygni. My second novel, Spider Star, to appear early in 2006, takes place in and around a dark matter ``planet'' orbiting a neutron star. Both novels are ``hard'' science fiction, relying on accurate physics to inform the tales. It's possible to bring to life abstract concepts like special relativity, and alien environments like accretion disks, by using science fiction. Novels are difficult to use in a science class, but short stories offer intriguing possibilities. I'm planning to edit an anthology of hard science fiction stories that contain accurate science and emphasize fundamental ideas in modern astronomy. The working title is Diamonds in the Sky. The collection will be a mix of original stories and reprints, highlighting challenging concepts covered in a typical introductory astronomy course. Larry Niven's classic story, ``Neutron Star," is an excellent demonstration of extreme tidal forces in an astronomical context. Diamonds in the Sky will include forewards and afterwards to the stories, including discussion questions and mathematical formulas/examples as appropriate. I envision this project will be published electronically or through a print-on-demand publisher, providing long-term availabilty and keeping low cost. I encourage interested parties to suggest previously published stories, or to suggest which topics must be included.

  15. Sky Detection in Hazy Image.

    Science.gov (United States)

    Song, Yingchao; Luo, Haibo; Ma, Junkai; Hui, Bin; Chang, Zheng

    2018-04-01

    Sky detection plays an essential role in various computer vision applications. Most existing sky detection approaches, being trained on ideal dataset, may lose efficacy when facing unfavorable conditions like the effects of weather and lighting conditions. In this paper, a novel algorithm for sky detection in hazy images is proposed from the perspective of probing the density of haze. We address the problem by an image segmentation and a region-level classification. To characterize the sky of hazy scenes, we unprecedentedly introduce several haze-relevant features that reflect the perceptual hazy density and the scene depth. Based on these features, the sky is separated by two imbalance SVM classifiers and a similarity measurement. Moreover, a sky dataset (named HazySky) with 500 annotated hazy images is built for model training and performance evaluation. To evaluate the performance of our method, we conducted extensive experiments both on our HazySky dataset and the SkyFinder dataset. The results demonstrate that our method performs better on the detection accuracy than previous methods, not only under hazy scenes, but also under other weather conditions.

  16. Stereological Investigation of the Effects of Treadmill Running Exercise on the Hippocampal Neurons in Middle-Aged APP/PS1 Transgenic Mice.

    Science.gov (United States)

    Chao, Fenglei; Jiang, Lin; Zhang, Yi; Zhou, Chunni; Zhang, Lei; Tang, Jing; Liang, Xin; Qi, Yingqiang; Zhu, Yanqing; Ma, Jing; Tang, Yong

    2018-01-01

    The risk of cognitive decline during Alzheimer's disease (AD) can be reduced if physical activity is maintained; however, the specific neural events underlying this beneficial effect are still uncertain. To quantitatively investigate the neural events underlying the effect of running exercise on middle-aged AD subjects, 12-month-old male APP/PS1 mice were randomly assigned to a control group or running group, and age-matched non-transgenic littermates were used as a wild-type group. AD running group mice were subjected to a treadmill running protocol (regular and moderate intensity) for four months. Spatial learning and memory abilities were assessed using the Morris water maze. Hippocampal amyloid plaques were observed using Thioflavin S staining and immunohistochemistry. Hippocampal volume, number of neurons, and number of newborn cells (BrdU+ cells) in the hippocampus were estimated using stereological techniques, and newborn neurons were observed using double-labelling immunofluorescence. Marked neuronal loss in both the CA1 field and dentate gyrus (DG) and deficits in both the neurogenesis and survival of new neurons in the DG of middle-aged APP/PS1 mice were observed. Running exercise could improve the spatial learning and memory abilities, reduce amyloid plaques in the hippocampi, delay neuronal loss, induce neurogenesis, and promote the survival of newborn neurons in the DG of middle-aged APP/PS1 mice. Exercise-induced protection of neurons and adult neurogenesis within the DG might be part of the important structural basis of the improved spatial learning and memory abilities observed in AD mice.

  17. Glutathione-mimetic D609 alleviates memory deficits and reduces amyloid-β deposition in an AβPP/PS1 transgenic mouse model.

    Science.gov (United States)

    Yang, Hui; Xie, ZhaoHong; Wei, LiFei; Ding, Mao; Wang, Ping; Bi, JianZhong

    2018-04-18

    Excessive extracellular deposition of amyloid-β-peptide (Aβ) in the brain is a pathological hallmark of Alzheimer's disease (AD). Oxidative stress is associated with the onset and progression of AD and contributes to Aβ generation. Tricyclodecan-9-yl-xanthogenate (D609) is a glutathione (GSH)-mimetic compound. Although the antioxidant properties of D609 have been well-studied, its potential therapeutic significance on AD remains unclear. In the present study, we used a mouse model of AD to investigate the effects and the mechanism of action of D609 on AD. We found that D609 treatment significantly improved the spatial learning and alleviated the memory decline in the mice harboring amyloid precursor protein (APP) and presenilin-1 (PS1) double mutations (AβPP/PS1 mice). D609 treatment also increased GSH level, GSH and oxidative glutathione ratio, and superoxide dismutase activity, whereas decreased malondialdehyde and protein carbonyl levels, suggesting that D609 alleviated oxidative stress in AβPP/PS1 mice. In addition, D609 reduced β-secretase 1 level and decreased amyloidogenic processing of AβPP, consequently reducing Aβ deposition in the mice. Thus, our findings suggest that D609 might produce beneficial effects on the prevention and treatment of AD.This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/.

  18. High-fat-diet-induced weight gain ameliorates bone loss without exacerbating AβPP processing and cognition in female APP/PS1 mice

    Directory of Open Access Journals (Sweden)

    Yunhua ePeng

    2014-08-01

    Full Text Available Osteoporosis is negatively correlated with body mass, whereas both osteoporosis and weight loss occur at higher incidence during the progression of Alzheimer’s disease (AD than the age-matched non-dementia individuals. Given that there is no evidence that overweight associated with AD-type cognitive dysfunction, we hypothesized that moderate weight gain might have a protective effect on the bone loss in AD without exacerbating cognitive dysfunction. In the present study, feeding a high-fat-diet (HFD, 45% calorie from fat to female APP/PS1 transgenic mice, an AD animal model, induced weight gain. The bone mineral density, microarchitecture, and biomechanical properties of the femurs were then evaluated. The results showed that the middle-aged female APP/PS1 transgenic mice were susceptible to osteoporosis of the femoral bones and that weight gain significantly enhanced bone mass and mechanical properties. Notably, HFD was not detrimental to brain insulin signaling and AβPP processing, as well as to exploration ability and working, learning and memory performance of the transgenic mice measured by T maze and water maze, compared with the mice fed a normal fat diet (10% calorie from fat. In addition, the circulating levels of leptin but not estradiol were remarkably elevated in HFD-treated mice. These results suggest that a body weight gain induced by the HFD feeding regimen significantly improved bone mass in female APP/PS1 mice with no detriments to exploration ability and spatial memory, most likely via the action of elevated circulating leptin.

  19. In vivo quantitative whole-brain diffusion tensor imaging analysis of APP/PS1 transgenic mice using voxel-based and atlas-based methods

    International Nuclear Information System (INIS)

    Qin, Yuan-Yuan; Li, Mu-Wei; Oishi, Kenichi; Zhang, Shun; Zhang, Yan; Zhao, Ling-Yun; Zhu, Wen-Zhen; Lei, Hao

    2013-01-01

    Diffusion tensor imaging (DTI) has been applied to characterize the pathological features of Alzheimer's disease (AD) in a mouse model, although little is known about whether these features are structure specific. Voxel-based analysis (VBA) and atlas-based analysis (ABA) are good complementary tools for whole-brain DTI analysis. The purpose of this study was to identify the spatial localization of disease-related pathology in an AD mouse model. VBA and ABA quantification were used for the whole-brain DTI analysis of nine APP/PS1 mice and wild-type (WT) controls. Multiple scalar measurements, including fractional anisotropy (FA), trace, axial diffusivity (DA), and radial diffusivity (DR), were investigated to capture the various types of pathology. The accuracy of the image transformation applied for VBA and ABA was evaluated by comparing manual and atlas-based structure delineation using kappa statistics. Following the MR examination, the brains of the animals were analyzed for microscopy. Extensive anatomical alterations were identified in APP/PS1 mice, in both the gray matter areas (neocortex, hippocampus, caudate putamen, thalamus, hypothalamus, claustrum, amygdala, and piriform cortex) and the white matter areas (corpus callosum/external capsule, cingulum, septum, internal capsule, fimbria, and optic tract), evidenced by an increase in FA or DA, or both, compared to WT mice (p 0.05). The histopathological changes in the gray matter areas were confirmed by microscopy studies. DTI did, however, demonstrate significant changes in white matter areas, where the difference was not apparent by qualitative observation of a single-slice histological specimen. This study demonstrated the structure-specific nature of pathological changes in APP/PS1 mouse, and also showed the feasibility of applying whole-brain analysis methods to the investigation of an AD mouse model. (orig.)

  20. Sphingosine kinase 1/sphingosine-1-phosphate (S1P)/S1P receptor axis is involved in ovarian cancer angiogenesis.

    Science.gov (United States)

    Dai, Lan; Liu, Yixuan; Xie, Lei; Wu, Xia; Qiu, Lihua; Di, Wen

    2017-09-26

    Sphingosine kinase (SphK)/sphingosine-1-phosphate (S1P)/S1P receptor (S1PR) signaling pathway has been implicated in a variety of pathological processes of ovarian cancer. However, the function of this axis in ovarian cancer angiogenesis remains incompletely defined. Here we provided the first evidence that SphK1/S1P/S1PR 1/3 pathway played key roles in ovarian cancer angiogenesis. The expression level of SphK1, but not SphK2, was closely correlated with the microvascular density (MVD) of ovarian cancer tissue. In vitro , the angiogenic potential and angiogenic factor secretion of ovarian cancer cells could be attenuated by SphK1, but not SphK2, blockage and were restored by the addition of S1P. Moreover, in these cells, we found S1P stimulation induced the angiogenic factor secretion via S1PR 1 and S1PR 3 , but not S1PR 2 . Furthermore, inhibition of S1PR 1/3 , but not S1PR 2 , attenuated the angiogenic potential and angiogenic factor secretion of the cells. in vivo , blockage of SphK or S1PR 1/3 could attenuate ovarian cancer angiogenesis and inhibit angiogenic factor expression in mouse models. Collectively, the current study showed a novel role of SphK1/S1P/S1PR 1/3 axis within the ovarian cancer, suggesting a new target to block ovarian cancer angiogenesis.

  1. Huperzine A alleviates synaptic deficits and modulates amyloidogenic and nonamyloidogenic pathways in APPswe/PS1dE9 transgenic mice.

    Science.gov (United States)

    Wang, Ying; Tang, Xi Can; Zhang, Hai Yan

    2012-02-01

    Huperzine A (HupA) is a potent acetylcholinesterase inhibitor (AChEI) used in the treatment of Alzheimer's disease (AD). Recently, HupA was shown to be active in modulating the nonamyloidogenic metabolism of β-amyloid precursor protein (APP) in APP-transfected human embryonic kidney cell line (HEK293swe). However, in vivo research concerning the mechanism of HupA in APP transgenic mice has not yet been fully elucidated. The present study indicates that the loss of dendritic spine density and synaptotagmin levels in the brain of APPswe/presenilin-1 (PS1) transgenic mice was significantly ameliorated by chronic HupA treatment and provides evidence that this neuroprotection was associated with reduced amyloid plaque burden and oligomeric β-amyloid (Aβ) levels in the cortex and hippocampus of APPswe/PS1dE9 transgenic mice. Our findings further demonstrate that the amelioration effect of HupA on Aβ deposits may be mediated, at least in part, by regulation of the compromised expression of a disintegrin and metalloprotease 10 (ADAM10) and excessive membrane trafficking of β-site APP cleavage enzyme 1 (BACE1) in these transgenic mice. In addition, extracellular signal-regulated kinases 1/2 (Erk1/2) phosphorylation may also be partially involved in the effect of HupA on APP processing. In conclusion, our work for the first time demonstrates the neuroprotective effect of HupA on synaptic deficits in APPswe/PS1dE9 transgenic mice and further clarifies the potential pharmacological targets for this protective effect, in which modulation of nonamyloidogenic and amyloidogenic APP processing pathways may be both involved. These findings may provide adequate evidence for the clinical and experimental benefits gained from HupA treatment. Copyright © 2011 Wiley Periodicals, Inc.

  2. Erinacine A-enriched Hericium erinaceus mycelium ameliorates Alzheimer's disease-related pathologies in APPswe/PS1dE9 transgenic mice.

    Science.gov (United States)

    Tsai-Teng, Tzeng; Chin-Chu, Chen; Li-Ya, Lee; Wan-Ping, Chen; Chung-Kuang, Lu; Chien-Chang, Shen; Chi-Ying, Huang F; Chien-Chih, Chen; Shiao, Young-Ji

    2016-06-27

    The fruiting body of Hericium erinaceus has been demonstrated to possess anti-dementia activity in mouse model of Alzheimer's disease and people with mild cognitive impairment. However, the therapeutic potential of Hericium erinaceus mycelia on Alzheimer's disease remains unclear. In this study, the effects of erinacine A-enriched Hericium erinaceus mycelia (HE-My) on the pathological changes in APPswe/PS1dE9 transgenic mouse model of Alzheimer's disease are studied. After a 30 day oral administration to 5 month-old female APPswe/PS1dE9 transgenic mice, we found that HE-My and its ethanol extracts (HE-Et) attenuated cerebral Aβ plaque burden. It's worth noting that the attenuated portion of a plaque is the non-compact structure. The level of insulin-degrading enzyme was elevated by both HE-My and HE-Et in cerebral cortex. On the other hand, the number of plaque-activated microglia and astrocytes in cerebral cortex and hippocampus were diminished, the ratio of nerve growth factor (NGF) to NGF precursor (proNGF) was increased and hippocampal neurogenesis was promoted after these administrations. All the mentioned benefits of these administrations may therefore improve the declined activity of daily living skill in APPswe/PS1dE9 transgenic mice. These results highlight the therapeutic potential of HE-My and HE-Et on Alzheimer's disease. Therefore, the effective components of HE-My and HE-Et are worth to be developed to become a therapeutic drug for Alzheimer's disease.

  3. Brain energy metabolism and neuroinflammation in ageing APP/PS1-21 mice using longitudinal 18F-FDG and 18F-DPA-714 PET imaging.

    Science.gov (United States)

    Takkinen, Jatta S; López-Picón, Francisco R; Al Majidi, Rana; Eskola, Olli; Krzyczmonik, Anna; Keller, Thomas; Löyttyniemi, Eliisa; Solin, Olof; Rinne, Juha O; Haaparanta-Solin, Merja

    2017-08-01

    Preclinical animal model studies of brain energy metabolism and neuroinflammation in Alzheimer's disease have produced conflicting results, hampering both the elucidation of the underlying disease mechanism and the development of effective Alzheimer's disease therapies. Here, we aimed to quantify the relationship between brain energy metabolism and neuroinflammation in the APP/PS1-21 transgenic mouse model of Alzheimer's disease using longitudinal in vivo 18 F-FDG and 18 F-DPA-714) PET imaging and ex vivo brain autoradiography. APP/PS1-21 (TG, n = 9) and wild type control mice (WT, n = 9) were studied longitudinally every third month from age 6 to 15 months with 18 F-FDG and 18 F-DPA-714 with a one-week interval between the scans. Additional TG (n = 52) and WT (n = 29) mice were used for ex vivo studies. In vivo, the 18 F-FDG SUVs were lower and the 18 F-DPA-714 binding ratios relative to the cerebellum were higher in the TG mouse cortex and hippocampus than in WT mice at age 12 to 15 months ( p < 0.05). The ex vivo cerebellum binding ratios supported the results of the in vivo 18 F-DPA-714 studies but not the 18 F-FDG studies. This longitudinal PET study demonstrated decreased energy metabolism and increased inflammation in the brains of APP/PS1-21 mice compared to WT mice.

  4. The Effects of Peripheral and Central High Insulin on Brain Insulin Signaling and Amyloid-β in Young and Old APP/PS1 Mice.

    Science.gov (United States)

    Stanley, Molly; Macauley, Shannon L; Caesar, Emily E; Koscal, Lauren J; Moritz, Will; Robinson, Grace O; Roh, Joseph; Keyser, Jennifer; Jiang, Hong; Holtzman, David M

    2016-11-16

    Hyperinsulinemia is a risk factor for late-onset Alzheimer's disease (AD). In vitro experiments describe potential connections between insulin, insulin signaling, and amyloid-β (Aβ), but in vivo experiments are needed to validate these relationships under physiological conditions. First, we performed hyperinsulinemic-euglycemic clamps with concurrent hippocampal microdialysis in young, awake, behaving APP swe /PS1 dE9 transgenic mice. Both a postprandial and supraphysiological insulin clamp significantly increased interstitial fluid (ISF) and plasma Aβ compared with controls. We could detect no increase in brain, ISF, or CSF insulin or brain insulin signaling in response to peripheral hyperinsulinemia, despite detecting increased signaling in the muscle. Next, we delivered insulin directly into the hippocampus of young APP/PS1 mice via reverse microdialysis. Brain tissue insulin and insulin signaling was dose-dependently increased, but ISF Aβ was unchanged by central insulin administration. Finally, to determine whether peripheral and central high insulin has differential effects in the presence of significant amyloid pathology, we repeated these experiments in older APP/PS1 mice with significant amyloid plaque burden. Postprandial insulin clamps increased ISF and plasma Aβ, whereas direct delivery of insulin to the hippocampus significantly increased tissue insulin and insulin signaling, with no effect on Aβ in old mice. These results suggest that the brain is still responsive to insulin in the presence of amyloid pathology but increased insulin signaling does not acutely modulate Aβ in vivo before or after the onset of amyloid pathology. Peripheral hyperinsulinemia modestly increases ISF and plasma Aβ in young and old mice, independent of neuronal insulin signaling. The transportation of insulin from blood to brain is a saturable process relevant to understanding the link between hyperinsulinemia and AD. In vitro experiments have found direct connections

  5. Improvement of spatial memory function in APPswe/PS1dE9 mice after chronic inhibition of phosphodiesterase type 4D.

    Science.gov (United States)

    Sierksma, A S R; van den Hove, D L A; Pfau, F; Philippens, M; Bruno, O; Fedele, E; Ricciarelli, R; Steinbusch, H W M; Vanmierlo, T; Prickaerts, J

    2014-02-01

    Phosphodiesterase type 4 inhibitors (PDE4-Is) have received increasing attention as cognition-enhancers and putative treatment strategies for Alzheimer's disease (AD). By preventing cAMP breakdown, PDE4-Is can enhance intracellular signal transduction and increase the phosphorylation of cAMP response element-binding protein (CREB) and transcription of proteins related to synaptic plasticity and associated memory formation. Unfortunately, clinical development of PDE4-Is has been seriously hampered by emetic side effects. The new isoform-specific PDE4D-I, GEBR-7b, has shown to have beneficial effects on memory at non-emetic doses. The aim of the current study was to investigate chronic cognition-enhancing effects of GEBR-7b in a mouse model of AD. To this extent, 5-month-old (5M) APPswe/PS1dE9 mice received daily subcutaneous injections with GEBR-7b (0.001 mg/kg) or vehicle for a period of 3 weeks, and were tested on affective and cognitive behavior at 7M. We demonstrated a cognition-enhancing potential in APPswe/PS1dE9 mice as their spatial memory function at 7M in the object location test was improved by prior GEBR-7b treatment. APPswe/PS1dE9 mice displayed lower levels of CREB phosphorylation, which remained unaltered after chronic GEBR-7b treatment, and higher levels of tau in the hippocampus. Hippocampal brain-derived neurotrophic factor levels and synaptic densities were not different between experimental groups and no effects were observed on hippocampal GSK3β and tau phosphorylation or Aβ levels. In conclusion, GEBR-7b can enhance spatial memory function in the APPswe/PS1dE9 mouse model of AD. Although the underlying mechanisms of its cognition-enhancing potential remain to be elucidated, PDE4D inhibition appears an interesting novel therapeutic option for cognitive deficits in AD. Copyright © 2013 Elsevier Ltd. All rights reserved.

  6. Repeated intraperitoneal injections of liposomes containing phosphatidic acid and cardiolipin reduce amyloid-β levels in APP/PS1 transgenic mice

    DEFF Research Database (Denmark)

    Ordóñez-Gutiérrez, Lara; Re, Francesca; Bereczki, Erika

    2015-01-01

    , it was hypothesized that shifting this equilibrium towards the blood by enhancing peripheral clearance might reduce Aβ levels in the brain: the 'sink effect'. We tested this hypothesis by intraperitoneally injecting APP/PS1 transgenic mice with small unilamellar vesicles containing either phosphatidic acid...... Aβ may be therapeutically relevant in AD. FROM THE CLINICAL EDITOR: Intraperitoneal injection of small unilamellar vesicles containing phosphatidic acid or cardiolipin significantly reduced the amount of amyloid-beta (Aß) peptide in the plasma in a rodent model. Brain levels of Aß were also affected...

  7. In vivo quantitative whole-brain diffusion tensor imaging analysis of APP/PS1 transgenic mice using voxel-based and atlas-based methods

    Energy Technology Data Exchange (ETDEWEB)

    Qin, Yuan-Yuan [Huazhong University of Science and Technology, Department of Radiology, Tongji Hospital, Tongji Medical College, Wuhan (China); The Johns Hopkins University School of Medicine, The Russell H. Morgan Department of Radiology and Radiological Science, Baltimore, MD (United States); Li, Mu-Wei; Oishi, Kenichi [The Johns Hopkins University School of Medicine, The Russell H. Morgan Department of Radiology and Radiological Science, Baltimore, MD (United States); Zhang, Shun; Zhang, Yan; Zhao, Ling-Yun; Zhu, Wen-Zhen [Huazhong University of Science and Technology, Department of Radiology, Tongji Hospital, Tongji Medical College, Wuhan (China); Lei, Hao [Chinese Academy of Sciences, Wuhan Center for Magnetic Resonance, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Wuhan (China)

    2013-08-15

    Diffusion tensor imaging (DTI) has been applied to characterize the pathological features of Alzheimer's disease (AD) in a mouse model, although little is known about whether these features are structure specific. Voxel-based analysis (VBA) and atlas-based analysis (ABA) are good complementary tools for whole-brain DTI analysis. The purpose of this study was to identify the spatial localization of disease-related pathology in an AD mouse model. VBA and ABA quantification were used for the whole-brain DTI analysis of nine APP/PS1 mice and wild-type (WT) controls. Multiple scalar measurements, including fractional anisotropy (FA), trace, axial diffusivity (DA), and radial diffusivity (DR), were investigated to capture the various types of pathology. The accuracy of the image transformation applied for VBA and ABA was evaluated by comparing manual and atlas-based structure delineation using kappa statistics. Following the MR examination, the brains of the animals were analyzed for microscopy. Extensive anatomical alterations were identified in APP/PS1 mice, in both the gray matter areas (neocortex, hippocampus, caudate putamen, thalamus, hypothalamus, claustrum, amygdala, and piriform cortex) and the white matter areas (corpus callosum/external capsule, cingulum, septum, internal capsule, fimbria, and optic tract), evidenced by an increase in FA or DA, or both, compared to WT mice (p < 0.05, corrected). The average kappa value between manual and atlas-based structure delineation was approximately 0.8, and there was no significant difference between APP/PS1 and WT mice (p > 0.05). The histopathological changes in the gray matter areas were confirmed by microscopy studies. DTI did, however, demonstrate significant changes in white matter areas, where the difference was not apparent by qualitative observation of a single-slice histological specimen. This study demonstrated the structure-specific nature of pathological changes in APP/PS1 mouse, and also showed the

  8. Long-Term Treatment with Liraglutide, a Glucagon-Like Peptide-1 (GLP-1 Receptor Agonist, Has No Effect on β-Amyloid Plaque Load in Two Transgenic APP/PS1 Mouse Models of Alzheimer's Disease.

    Directory of Open Access Journals (Sweden)

    Henrik H Hansen

    Full Text Available One of the major histopathological hallmarks of Alzheimer's disease (AD is cerebral deposits of extracellular β-amyloid peptides. Preclinical studies have pointed to glucagon-like peptide 1 (GLP-1 receptors as a potential novel target in the treatment of AD. GLP-1 receptor agonists, including exendin-4 and liraglutide, have been shown to promote plaque-lowering and mnemonic effects of in a number of experimental models of AD. Transgenic mouse models carrying genetic mutations of amyloid protein precursor (APP and presenilin-1 (PS1 are commonly used to assess the pharmacodynamics of potential amyloidosis-lowering and pro-cognitive compounds. In this study, effects of long-term liraglutide treatment were therefore determined in two double APP/PS1 transgenic mouse models of Alzheimer's disease carrying different clinical APP/PS1 mutations, i.e. the 'London' (hAPPLon/PS1A246E and 'Swedish' mutation variant (hAPPSwe/PS1ΔE9 of APP, with co-expression of distinct PS1 variants. Liraglutide was administered in 5 month-old hAPPLon/PS1A246E mice for 3 months (100 or 500 ng/kg/day, s.c., or 7 month-old hAPPSwe/PS1ΔE9 mice for 5 months (500 ng/kg/day, s.c.. In both models, regional plaque load was quantified throughout the brain using stereological methods. Vehicle-dosed hAPPSwe/PS1ΔE9 mice exhibited considerably higher cerebral plaque load than hAPPLon/PS1A246E control mice. Compared to vehicle-dosed transgenic controls, liraglutide treatment had no effect on the plaque levels in hAPPLon/PS1A246E and hAPPSwe/PS1ΔE9 mice. In conclusion, long-term liraglutide treatment exhibited no effect on cerebral plaque load in two transgenic mouse models of low- and high-grade amyloidosis, which suggests differential sensitivity to long-term liraglutide treatment in various transgenic mouse models mimicking distinct pathological hallmarks of AD.

  9. SCM-198 Ameliorates Cognitive Deficits, Promotes Neuronal Survival and Enhances CREB/BDNF/TrkB Signaling without Affecting Aβ Burden in AβPP/PS1 Mice

    Directory of Open Access Journals (Sweden)

    Zhen-Yi Hong

    2015-08-01

    Full Text Available SCM-198 is an alkaloid found only in Herba leonuri and it has been reported to possess considerable neuroprotective effects in animal models of ischemic stroke, Parkinson’s disease and Alzheimer’s disease (AD. In this study, we demonstrated for the first time that 3-month oral SCM-198 treatment could significantly improve both recognition and spatial memory, inhibit microgliosis and promote neuronal survival in amyloid-β protein precursor and presenilin-1(AβPP/PS1 double-transgenic mice without affecting amyloid-β (Aβ burden. In addition, decreases in cAMP-response element-binding protein (CREB phosphorylation, brain-derived neurotrophic factor (BDNF and tropomyosin-related kinase B (TrkB phosphorylation were attenuated by SCM-198 both in vivo and in primary cortical neurons, which could be blocked by protein kinase A (PKA inhibitors, suggesting the involvement of upstream PKA in enhancing the BDNF/TrkB/CREB signaling by SCM-198. Our results indicate that SCM-198, a drug that could promote neuronal survival and enhance BDNF/TrkB/CREB signaling, has beneficial effects on behavioral and biochemical alterations without affecting Aβ burden in AβPP/PS1 mice and might become a potential drug candidate for AD treatment in the future.

  10. SCM-198 Ameliorates Cognitive Deficits, Promotes Neuronal Survival and Enhances CREB/BDNF/TrkB Signaling without Affecting Aβ Burden in AβPP/PS1 Mice.

    Science.gov (United States)

    Hong, Zhen-Yi; Yu, Shuang-Shuang; Wang, Zhi-Jun; Zhu, Yi-Zhun

    2015-08-07

    SCM-198 is an alkaloid found only in Herba leonuri and it has been reported to possess considerable neuroprotective effects in animal models of ischemic stroke, Parkinson's disease and Alzheimer's disease (AD). In this study, we demonstrated for the first time that 3-month oral SCM-198 treatment could significantly improve both recognition and spatial memory, inhibit microgliosis and promote neuronal survival in amyloid-β protein precursor and presenilin-1(AβPP/PS1) double-transgenic mice without affecting amyloid-β (Aβ) burden. In addition, decreases in cAMP-response element-binding protein (CREB) phosphorylation, brain-derived neurotrophic factor (BDNF) and tropomyosin-related kinase B (TrkB) phosphorylation were attenuated by SCM-198 both in vivo and in primary cortical neurons, which could be blocked by protein kinase A (PKA) inhibitors, suggesting the involvement of upstream PKA in enhancing the BDNF/TrkB/CREB signaling by SCM-198. Our results indicate that SCM-198, a drug that could promote neuronal survival and enhance BDNF/TrkB/CREB signaling, has beneficial effects on behavioral and biochemical alterations without affecting Aβ burden in AβPP/PS1 mice and might become a potential drug candidate for AD treatment in the future.

  11. Maternal separation exacerbates Alzheimer's disease-like behavioral and pathological changes in adult APPswe/PS1dE9 mice.

    Science.gov (United States)

    Hui, Jianjun; Feng, Gaifeng; Zheng, Caifeng; Jin, Hui; Jia, Ning

    2017-02-01

    Alzheimer's disease (AD), the most common neurodegenerative disorder that gradually destroys memory and cognitive abilities in the elderly, makes a huge emotional and economic burden on the patients and their families. The presence of senile plaques and the loss of cholinergic neurons in the brain are two neuropathological hallmarks of AD. Maternal separation (MS) is an animal paradigm designed to make early life stress. Studies on wild type rodents showed that MS could induce AD-like cognitive deficit and pathological changes. However, the effects of MS on AD susceptible population or AD animal models are still unclear. In the present study, male APPswe/PS1dE9 transgenic mice were separated from dam and pups 3h per day from postnatal day 2 to day 21. After weaning, all animals were housed under normal conditions (4 mice per cage). At 9-month age, MWM tests were performed to evaluate the learning and memory abilities. Then the pathological changes in the brain were measured by histology staining. The results showed MS mice had more severe deficit of learning and memory. Compared to the control, there were more senile plaques in cortex and hippocampus, fewer cholinergic neurons in nucleus basalis of Meynert in MS mice. These results indicate that MS exacerbates Alzheimer's disease-like behavioral and pathological changes in APPswe/PS1dE9 mice. Copyright © 2016 Elsevier B.V. All rights reserved.

  12. Antagonist of peroxisome proliferator-activated receptor γ induces cerebellar amyloid-β levels and motor dysfunction in APP/PS1 transgenic mice

    International Nuclear Information System (INIS)

    Du, Jing; Sun, Bing; Chen, Kui; Fan, Li; Wang, Zhao

    2009-01-01

    Recent evidences show that peroxisome proliferator-activated receptor γ (PPARγ) is involved in the modulation of the amyloid-β (Aβ) cascade causing Alzheimer's disease (AD) and treatment with PPARγ agonists protects against AD pathology. However, the function of PPARγ steady-state activity in Aβ cascade and AD pathology remains unclear. In this study, an antagonist of PPARγ, GW9662, was injected into the fourth ventricle of APP/PS1 transgenic mice to inhibit PPARγ activity in cerebellum. The results show that inhibition of PPARγ significantly induced Aβ levels in cerebellum and caused cerebellar motor dysfunction in APP/PS1 transgenic mice. Moreover, GW9662 treatment markedly decreased the cerebellar levels of insulin-degrading enzyme (IDE), which is responsible for the cellular degradation of Aβ. Since cerebellum is spared from significant Aβ accumulation and neurotoxicity in AD patients and animal models, these findings suggest a crucial role of PPARγ steady-state activity in protection of cerebellum against AD pathology.

  13. Exercise-Induced Neuroprotection of Hippocampus in APP/PS1 Transgenic Mice via Upregulation of Mitochondrial 8-Oxoguanine DNA Glycosylase

    Directory of Open Access Journals (Sweden)

    Hai Bo

    2014-01-01

    Full Text Available Improving mitochondrial function has been proposed as a reasonable therapeutic strategy to reduce amyloid-β (Aβ load and to modify the progression of Alzheimer’s disease (AD. However, the relationship between mitochondrial adaptation and brain neuroprotection caused by physical exercise in AD is poorly understood. This study was undertaken to investigate the effects of long-term treadmill exercise on mitochondrial 8-oxoguanine DNA glycosylase-1 (OGG1 level, mtDNA oxidative damage, and mitochondrial function in the hippocampus of APP/PS1 transgenic mouse model of AD. In the present study, twenty weeks of treadmill training significantly improved the cognitive function and reduced the expression of Aβ-42 in APP/PS1 transgenic (Tg mice. Training also ameliorated mitochondrial respiratory function by increasing the complexes I, and IV and ATP synthase activities, whereas it attenuated ROS generation and mtDNA oxidative damage in Tg mice. Furthermore, the impaired mitochondrial antioxidant enzymes and mitochondrial OGG1 activities seen in Tg mice were restored with training. Acetylation level of mitochondrial OGG1 and MnSOD was markedly suppressed in Tg mice after exercise training, in parallel with increased level of SIRT3. These findings suggest that exercise training could increase mtDNA repair capacity in the mouse hippocampus, which in turn would result in protection against AD-related mitochondrial dysfunction and phenotypic deterioration.

  14. Close to the Sky

    Science.gov (United States)

    2007-11-01

    Today, a new ALMA outreach and educational book was publicly presented to city officials of San Pedro de Atacama in Chile, as part of the celebrations of the anniversary of the Andean village. ESO PR Photo 50a/07 ESO PR Photo 50a/07 A Useful Tool for Schools Entitled "Close to the sky: Biological heritage in the ALMA area", and edited in English and Spanish by ESO in Chile, the book collects unique on-site observations of the flora and fauna of the ALMA region performed by experts commissioned to investigate it and to provide key initiatives to protect it. "I thank the ALMA project for providing us a book that will surely be a good support for the education of children and youngsters of San Pedro de Atacama. Thanks to this publication, we expect our rich flora and fauna to be better known. I invite teachers and students to take advantage of this educational resource, which will be available in our schools", commented Ms. Sandra Berna, the Mayor of San Pedro de Atacama, who was given the book by representatives of the ALMA global collaboration project. Copies of the book 'Close to the sky' will be donated to all schools in the area, as a contribution to the education of students and young people in northern Chile. "From the very beginning of the project, ALMA construction has had a firm commitment to environment and local culture, protecting unique flora and fauna species and preserving old estancias belonging to the Likan Antai culture," said Jacques Lassalle, who represented ALMA at the hand-over. "Animals like the llama, the fox or the condor do not only live in the region where ALMA is now being built, but they are also key elements of the ancient Andean constellations. In this sense they are part of the same sky that will be explored by ALMA in the near future." ESO PR Photo 50c/07 ESO PR Photo 50c/07 Presentation of the ALMA book The ALMA Project is a giant, international observatory currently under construction on the high-altitude Chajnantor site in Chile

  15. Night sky luminance under clear sky conditions: Theory vs. experiment

    International Nuclear Information System (INIS)

    Kocifaj, Miroslav

    2014-01-01

    Sky glow is caused by both natural phenomena and factors of anthropogenic origin, and of the latter ground-based light sources are the most important contributors for they emit the spatially linked spectral radiant intensity distribution of artificial light sources, which are further modulated by local atmospheric optics and perceived as the diffuse light of a night sky. In other words, sky glow is closely related to a city's shape and pattern of luminaire distribution, in practical effect an almost arbitrary deployment of random orientation of heterogeneous electrical light sources. Thus the luminance gradation function measured in a suburban zone or near the edges of a city is linked to the City Pattern or vice versa. It is shown that clear sky luminance/radiance data recorded in an urban area can be used to retrieve the bulk luminous/radiant intensity distribution if some a-priori information on atmospheric aerosols is available. For instance, the single scattering albedo of aerosol particles is required under low turbidity conditions, as demonstrated on a targeted experiment in the city of Frýdek-Mistek. One of the main advantages of the retrieval method presented in this paper is that the single scattering approximation is satisfactorily accurate in characterizing the light field near the ground because the dominant contribution to the sky glow has originated from beams propagated along short optical paths. - Highlights: • Urban sky glow is interpreted in terms of city emission function. • Luminance function in a suburban zone is linked to the City Pattern. • Single scattering approximation is applicable in modeling urban sky glow. • Information on aerosols represents valuable inputs to the retrieval procedure. • Sky glow patterns vary with light source distribution and spectral emission

  16. Sphingosine kinase/sphingosine 1-phosphate (S1P)/S1P receptor axis is involved in liver fibrosis-associated angiogenesis.

    Science.gov (United States)

    Yang, Le; Yue, Shi; Yang, Lin; Liu, Xin; Han, Zhen; Zhang, Yuanyuan; Li, Liying

    2013-07-01

    Sphingosine kinase (SphK)/sphingosine 1-phosphate (S1P)/S1P receptor (S1PR) axis is involved in multiple biological processes, including liver fibrosis. Angiogenesis is an important pathophysiological process closely associated with liver fibrosis; however, the functional role of SphK/S1P/S1PR in this process remains incompletely defined. Bile duct ligation or carbon tetrachloride was used to induce liver fibrosis in mice. Human fibrotic samples were obtained from livers of patients undergoing liver transplantation. S1P levels in the liver were examined by HPLC. Expression of angiogenic markers, including angiopoietin 1, CD31, vascular cell adhesion molecule-1, and von Willebrand factor, was characterized by immunofluorescence, real-time RT-PCR, and Western blot in the fibrotic liver and primary mouse hepatic stellate cells (HSCs). SphK inhibitor (SKI) or S1PR antagonists were administered intraperitoneally in mice. S1P levels in the liver were closely correlated with mRNA expression of angiogenic markers. Ang1 is expressed in activated HSCs of the fibrotic liver and in primary HSCs. In HSCs, by using specific antagonists or siRNAs, we demonstrated S1P stimulation induced Ang1 expression via S1PR1 and S1PR3. In vivo, S1P reduction by SKI inhibited angiogenesis in fibrotic mice. Furthermore, S1PR1/3 antagonist significantly blocked upregulation of angiogenic markers in the injured liver, and attenuated the extent of liver fibrosis, while S1PR2 antagonist had no effect on angiogenesis, supporting the key role of S1PR1 and S1PR3 in angiogenesis underlying liver fibrosis process. SphK1/S1P/S1PR1/3 axis plays a crucial role in the angiogenic process required for fibrosis development, which may represent an effective therapeutic strategy for liver fibrosis. Copyright © 2013 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

  17. [Role and related mechanism of S1P/S1P1 signal pathway during post conditioning of hypertrophic cardiomyocytes].

    Science.gov (United States)

    Bao, X H; Li, H X; Tao, J; Li, X M; Yang, Y N; Ma, Y T; Chen, B D

    2016-05-24

    To study the role and mechanism of sphingosine-1-phosphate (S1P)/ sphingosine-1-phosphate receptor 1(S1P1) signal pathway during post conditioning of hypertrophic cardiomyocytes. Neonatal rat cardiomyocytes were isolated and cultured, then stimulated by norepinephrine (NE) to induce cardiomyocytes hypertrophy. Using tri-gas incubator to create hypoxia and reoxygenation enviroment to mimic ischemia-reperfusion and postconditioning. Hypertrophic cardiomyoctyes were divided into five groups according to the presence or absence of various drugs and postconditiong and relevant signal pathways changes were detected: (1) IPost group (hypoxia+ postconditioning); (2) IPost+ S1P group (cells were pretreated with S1P (1 μmol/L) for 2 h before IPost); (3) IPost+ W-146+ S1P group (cells in IPost+ W-146+ S1P group were pretreated with S1P1 inhibitor W-146 (0.4 μmol/L) for 20 min); (4) IPost+ PD98059+ S1P group (cells in IPost+ S1P group were pretreated with MAPK antagonist PD98059 (125 μmol/L) for 20 min); (5) IPost+ LY-294002+ S1P group (cells in IPost+ S1P group were pretreated with PI3K antagonist LY294002 (0.1 μmol/L) for 20 min). Apoptosis was detected by flow cytometry and protein expression of relevant signal pathways were detected by Western blot. (1)Apoptosis rate was significantly increased in hypoxia/reoxygenation (27.90±4.49)% group compared with normal control group (7.97±2.18)%, which could be significantly reduced in IPost group (15.90±1.77)% (all PS1P and IPost+ S1P+ LY-294002 groups than in IPost and IPost+ S1P+ W-146 and IPost+ S1P+ PD98059 group (all PS1P and IPost+ S1P+ LY-294002 group than in IPost and IPost+ S1P+ W-146 group and IPost+ S1P+ PD98059 group (all PS1P+ W-146 and IPost+ S1P+ PD98059 groups. p-ERK1/2 and p-Akt levels in IPost+ S1P+ W-146 group and IPost+ S1P+ PD98059 were similar as in IPost group. S1P can play protective role on NE induced cardiomyocytes hypertrophy during post conditioning through downregulating caspase-3 expression and

  18. Digital all-sky polarization imaging of partly cloudy skies.

    Science.gov (United States)

    Pust, Nathan J; Shaw, Joseph A

    2008-12-01

    Clouds reduce the degree of linear polarization (DOLP) of skylight relative to that of a clear sky. Even thin subvisual clouds in the "twilight zone" between clouds and aerosols produce a drop in skylight DOLP long before clouds become visible in the sky. In contrast, the angle of polarization (AOP) of light scattered by a cloud in a partly cloudy sky remains the same as in the clear sky for most cases. In unique instances, though, select clouds display AOP signatures that are oriented 90 degrees from the clear-sky AOP. For these clouds, scattered light oriented parallel to the scattering plane dominates the perpendicularly polarized Rayleigh-scattered light between the instrument and the cloud. For liquid clouds, this effect may assist cloud particle size identification because it occurs only over a relatively limited range of particle radii that will scatter parallel polarized light. Images are shown from a digital all-sky-polarization imager to illustrate these effects. Images are also shown that provide validation of previously published theories for weak (approximately 2%) polarization parallel to the scattering plane for a 22 degrees halo.

  19. Sky cover from MFRSR observations

    Directory of Open Access Journals (Sweden)

    E. Kassianov

    2011-07-01

    Full Text Available The diffuse all-sky surface irradiances measured at two nearby wavelengths in the visible spectral range and their modeled clear-sky counterparts are the main components of a new method for estimating the fractional sky cover of different cloud types, including cumuli. The performance of this method is illustrated using 1-min resolution data from a ground-based Multi-Filter Rotating Shadowband Radiometer (MFRSR. The MFRSR data are collected at the US Department of Energy Atmospheric Radiation Measurement (ARM Climate Research Facility (ACRF Southern Great Plains (SGP site during the summer of 2007 and represent 13 days with cumuli. Good agreement is obtained between estimated values of the fractional sky cover and those provided by a well-established independent method based on broadband observations.

  20. Reach the sky

    Science.gov (United States)

    Mariana Peicuti, Cristina

    2017-04-01

    I am working as primary teacher at Scoala Gimnaziala Dumbrava,Timis County, Romania & my pupils has 6 to 10 years old. I was&I am a main pillar in my community, always disseminating knowledge and experience to students, other teachers in the school area &Timis County.Astronomy is the must favorite subject of my students from my classes. They are very courious & always come to me with questions about Earth and Sky because Curriculum scientific disciplines provides too little information about Earth and Sky.I need to know more about how to teach space contents into my classes&what competencies can form in elementary school and also to share my experience to the others.As a result of participation at this meeting I want to attract as many students to astronomy,science/STEM disciplines&space technologies, to astronomy topics and exploration of outer space.Schools needs to be prepared for social life needs,new generations needs,on science/space technologies,which are one of the key points for developing the knowledge society.I intend to introduce new scientific activities as part of the existing curriculum.I am passionate about astronomy,I need to know new approaches and new ideas for primary because I think Science is very important in daily life. Here are some developed activities with pupils from K-2 grade levels wich I wish share with colleagues in Viena. Subject: MATHEMATICS. Primary Topic: MEASUREMENT : -+= ☼ Rockets by Size. Students cut out,color and sequence paper rockets/Read the information on the International Space Station and rockets/Gather pictures of different types of rockets/Print/cut out/color&laminate rocket drawings/Find objects in the room to put in order by height. ☼ Oil Spot Photometer - Measure the brightness of the sun using cooking oil and a white card. A smear of oil on a white card becomes a powerful tool for comparing the brightness of two light sources, including the sun. ☼ The Sundial & Making Shadows-device to measure time by the

  1. Association of Sphingosine-1-phosphate (S1P)/S1P Receptor-1 Pathway with Cell Proliferation and Survival in Canine Hemangiosarcoma.

    Science.gov (United States)

    Rodriguez, A M; Graef, A J; LeVine, D N; Cohen, I R; Modiano, J F; Kim, J-H

    2015-01-01

    Sphingosine-1-phosphate (S1P) is a key biolipid signaling molecule that regulates cell growth and survival, but it has not been studied in tumors from dogs. S1P/S1P1 signaling will contribute to the progression of hemangiosarcoma (HSA). Thirteen spontaneous HSA tissues, 9 HSA cell lines, 8 nonmalignant tissues, including 6 splenic hematomas and 2 livers with vacuolar degeneration, and 1 endothelial cell line derived from a dog with splenic hematoma were used. This was a retrospective case series and in vitro study. Samples were obtained as part of medically necessary diagnostic procedures. Microarray, qRT-PCR, immunohistochemistry, and immunoblotting were performed to examine S1P1 expression. S1P concentrations were measured by high-performance liquid chromatography/mass spectrometry. S1P signaling was evaluated by intracellular Ca(2+) mobilization; proliferation and survival were evaluated using the MTS assay and Annexin V staining. Canine HSA cells expressed higher levels of S1P1 mRNA than nonmalignant endothelial cells. S1P1 protein was present in HSA tissues and cell lines. HSA cells appeared to produce low levels of S1P, but they selectively consumed S1P from the culture media. Exogenous S1P induced an increase in intracellular calcium as well as increased proliferation and viability of HSA cells. Prolonged treatment with FTY720, an inhibitor of S1P1 , decreased S1P1 protein expression and induced apoptosis of HSA cells. S1P/S1P1 signaling pathway functions to maintain HSA cell viability and proliferation. The data suggest that S1P1 or the S1P pathway in general could be targets for therapeutic intervention for dogs with HSA. Copyright © 2015 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.

  2. Smad3 deficiency leads to mandibular condyle degradation via the sphingosine 1-phosphate (S1P)/S1P3 signaling axis.

    Science.gov (United States)

    Mori, Hiroki; Izawa, Takashi; Tanaka, Eiji

    2015-10-01

    Temporomandibular joint osteoarthritis is a degenerative disease that is characterized by permanent cartilage destruction. Transforming growth factor (TGF)-β is one of the most abundant cytokines in the bone matrix and is shown to regulate the migration of osteoprogenitor cells. It is hypothesized that TGF-β/Smad3 signaling affects cartilage homeostasis by influencing sphingosine 1-phosphate (S1P)/S1P receptor signaling and chondrocyte migration. We therefore investigated the molecular mechanisms by which crosstalk may occur between TGF-β/Smad3 and S1P/S1P receptor signaling to maintain condylar cartilage and to prevent temporomandibular joint osteoarthritis. Abnormalities in the condylar subchondral bone, including dynamic changes in bone mineral density and microstructure, were observed in Smad3(-/-) mice by microcomputed tomography. Cell-free regions and proteoglycan loss characterized the cartilage degradation present, and increased numbers of apoptotic chondrocytes and matrix metalloproteinase 13(+) chondrocytes were also detected. Furthermore, expression of S1P receptor 3 (S1P3), but not S1P1 or S1P2, was significantly down-regulated in the condylar cartilage of Smad3(-/-) mice. By using RNA interference technology and pharmacologic tools, S1P was found to transactivate Smad3 in an S1P3/TGF-β type II receptor-dependent manner, and S1P3 was found to be required for TGF-β-induced migration of chondrocyte cells and downstream signal transduction via Rac1, RhoA, and Cdc42. Taken together, these results indicate that the Smad3/S1P3 signaling pathway plays an important role in the pathogenesis of temporomandibular joint osteoarthritis. Copyright © 2015 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

  3. Targeting the SphK1/S1P/S1PR1 Axis That Links Obesity, Chronic Inflammation, and Breast Cancer Metastasis.

    Science.gov (United States)

    Nagahashi, Masayuki; Yamada, Akimitsu; Katsuta, Eriko; Aoyagi, Tomoyoshi; Huang, Wei-Ching; Terracina, Krista P; Hait, Nitai C; Allegood, Jeremy C; Tsuchida, Junko; Yuza, Kizuki; Nakajima, Masato; Abe, Manabu; Sakimura, Kenji; Milstien, Sheldon; Wakai, Toshifumi; Spiegel, Sarah; Takabe, Kazuaki

    2018-04-01

    Although obesity with associated inflammation is now recognized as a risk factor for breast cancer and distant metastases, the functional basis for these connections remain poorly understood. Here, we show that in breast cancer patients and in animal breast cancer models, obesity is a sufficient cause for increased expression of the bioactive sphingolipid mediator sphingosine-1-phosphate (S1P), which mediates cancer pathogenesis. A high-fat diet was sufficient to upregulate expression of sphingosine kinase 1 (SphK1), the enzyme that produces S1P, along with its receptor S1PR1 in syngeneic and spontaneous breast tumors. Targeting the SphK1/S1P/S1PR1 axis with FTY720/fingolimod attenuated key proinflammatory cytokines, macrophage infiltration, and tumor progression induced by obesity. S1P produced in the lung premetastatic niche by tumor-induced SphK1 increased macrophage recruitment into the lung and induced IL6 and signaling pathways important for lung metastatic colonization. Conversely, FTY720 suppressed IL6, macrophage infiltration, and S1P-mediated signaling pathways in the lung induced by a high-fat diet, and it dramatically reduced formation of metastatic foci. In tumor-bearing mice, FTY720 similarly reduced obesity-related inflammation, S1P signaling, and pulmonary metastasis, thereby prolonging survival. Taken together, our results establish a critical role for circulating S1P produced by tumors and the SphK1/S1P/S1PR1 axis in obesity-related inflammation, formation of lung metastatic niches, and breast cancer metastasis, with potential implications for prevention and treatment. Significance: These findings offer a preclinical proof of concept that signaling by a sphingolipid may be an effective target to prevent obesity-related breast cancer metastasis. Cancer Res; 78(7); 1713-25. ©2018 AACR . ©2018 American Association for Cancer Research.

  4. Detection by voxel-wise statistical analysis of significant changes in regional cerebral glucose uptake in an APP/PS1 transgenic mouse model of Alzheimer's disease.

    Science.gov (United States)

    Dubois, Albertine; Hérard, Anne-Sophie; Delatour, Benoît; Hantraye, Philippe; Bonvento, Gilles; Dhenain, Marc; Delzescaux, Thierry

    2010-06-01

    Biomarkers and technologies similar to those used in humans are essential for the follow-up of Alzheimer's disease (AD) animal models, particularly for the clarification of mechanisms and the screening and validation of new candidate treatments. In humans, changes in brain metabolism can be detected by 1-deoxy-2-[(18)F] fluoro-D-glucose PET (FDG-PET) and assessed in a user-independent manner with dedicated software, such as Statistical Parametric Mapping (SPM). FDG-PET can be carried out in small animals, but its resolution is low as compared to the size of rodent brain structures. In mouse models of AD, changes in cerebral glucose utilization are usually detected by [(14)C]-2-deoxyglucose (2DG) autoradiography, but this requires prior manual outlining of regions of interest (ROI) on selected sections. Here, we evaluate the feasibility of applying the SPM method to 3D autoradiographic data sets mapping brain metabolic activity in a transgenic mouse model of AD. We report the preliminary results obtained with 4 APP/PS1 (64+/-1 weeks) and 3 PS1 (65+/-2 weeks) mice. We also describe new procedures for the acquisition and use of "blockface" photographs and provide the first demonstration of their value for the 3D reconstruction and spatial normalization of post mortem mouse brain volumes. Despite this limited sample size, our results appear to be meaningful, consistent, and more comprehensive than findings from previously published studies based on conventional ROI-based methods. The establishment of statistical significance at the voxel level, rather than with a user-defined ROI, makes it possible to detect more reliably subtle differences in geometrically complex regions, such as the hippocampus. Our approach is generic and could be easily applied to other biomarkers and extended to other species and applications. Copyright 2010 Elsevier Inc. All rights reserved.

  5. The Cyanthin Diterpenoid and Sesterterpene Constituents of Hericium erinaceus Mycelium Ameliorate Alzheimer’s Disease-Related Pathologies in APP/PS1 Transgenic Mice

    Science.gov (United States)

    Tzeng, Tsai-Teng; Chen, Chien-Chih; Chen, Chin-Chu; Tsay, Huey-Jen; Lee, Li-Ya; Chen, Wan-Ping

    2018-01-01

    Hericium erinaceus was used in traditional Chinese medicine for physiologically beneficial medicines. Recently, it has become a candidate in causing positive brain health-related activities. We previously reported that Hericium erinaceus mycelium ameliorates Alzheimer’s disease (AD)-related pathologies. To reveal the role of the cyanthin diterpenoid and sesterterpene constituents on this effects, erinacine A and S were isolated and their effects on attenuating AD-related pathology in APPswe/PS1dE9 transgenic mice were investigated. A 30 day short-term administration of erinacine A and S were performed to explore the effect of each erinacine on AD-related pathology including amyloid β production and degradation, plaque formation, plaque growth, glial activation and neurogenesis deterioration. Our results indicated the benefit effects of both erinacine A and S in cerebrum of APPswe/PS1dE9 mice, including: (1) attenuating cerebral plaque loading by inhibiting plaque growth; (2) diminishing the activation of glial cells; (3) raising the level of insulin degrading enzyme; and (4) promoting hippocampal neurogenesis. Moreover, erinacine A reduced the level of insoluble amyloid β and C-terminal fragment of amyloid precursor protein which was not mediated by erinacine S. We further performed a long term administration of erinacine A and found that erinacine A recovered the impairment in the tasks including burrowing, nesting, and Morris water maze. Our data pointed out that although both erinacine A and S reduce AD pathology via reducing amyloid deposition and promoting neurogenesis, erinacine A can also inhibit amyloid β production and is worth to be further developed for AD therapeutic use. PMID:29463001

  6. The Cyanthin Diterpenoid and Sesterterpene Constituents of Hericium erinaceus Mycelium Ameliorate Alzheimer's Disease-Related Pathologies in APP/PS1 Transgenic Mice.

    Science.gov (United States)

    Tzeng, Tsai-Teng; Chen, Chien-Chih; Chen, Chin-Chu; Tsay, Huey-Jen; Lee, Li-Ya; Chen, Wan-Ping; Shen, Chien-Chang; Shiao, Young-Ji

    2018-02-17

    Hericium erinaceus was used in traditional Chinese medicine for physiologically beneficial medicines. Recently, it has become a candidate in causing positive brain health-related activities. We previously reported that Hericium erinaceus mycelium ameliorates Alzheimer's disease (AD)-related pathologies. To reveal the role of the cyanthin diterpenoid and sesterterpene constituents on this effects, erinacine A and S were isolated and their effects on attenuating AD-related pathology in APPswe/PS1dE9 transgenic mice were investigated. A 30 day short-term administration of erinacine A and S were performed to explore the effect of each erinacine on AD-related pathology including amyloid β production and degradation, plaque formation, plaque growth, glial activation and neurogenesis deterioration. Our results indicated the benefit effects of both erinacine A and S in cerebrum of APPswe/PS1dE9 mice, including: (1) attenuating cerebral plaque loading by inhibiting plaque growth; (2) diminishing the activation of glial cells; (3) raising the level of insulin degrading enzyme; and (4) promoting hippocampal neurogenesis. Moreover, erinacine A reduced the level of insoluble amyloid β and C-terminal fragment of amyloid precursor protein which was not mediated by erinacine S. We further performed a long term administration of erinacine A and found that erinacine A recovered the impairment in the tasks including burrowing, nesting, and Morris water maze. Our data pointed out that although both erinacine A and S reduce AD pathology via reducing amyloid deposition and promoting neurogenesis, erinacine A can also inhibit amyloid β production and is worth to be further developed for AD therapeutic use.

  7. The Cyanthin Diterpenoid and Sesterterpene Constituents of Hericium erinaceus Mycelium Ameliorate Alzheimer’s Disease-Related Pathologies in APP/PS1 Transgenic Mice

    Directory of Open Access Journals (Sweden)

    Tsai-Teng Tzeng

    2018-02-01

    Full Text Available Hericium erinaceus was used in traditional Chinese medicine for physiologically beneficial medicines. Recently, it has become a candidate in causing positive brain health-related activities. We previously reported that Hericium erinaceus mycelium ameliorates Alzheimer’s disease (AD-related pathologies. To reveal the role of the cyanthin diterpenoid and sesterterpene constituents on this effects, erinacine A and S were isolated and their effects on attenuating AD-related pathology in APPswe/PS1dE9 transgenic mice were investigated. A 30 day short-term administration of erinacine A and S were performed to explore the effect of each erinacine on AD-related pathology including amyloid β production and degradation, plaque formation, plaque growth, glial activation and neurogenesis deterioration. Our results indicated the benefit effects of both erinacine A and S in cerebrum of APPswe/PS1dE9 mice, including: (1 attenuating cerebral plaque loading by inhibiting plaque growth; (2 diminishing the activation of glial cells; (3 raising the level of insulin degrading enzyme; and (4 promoting hippocampal neurogenesis. Moreover, erinacine A reduced the level of insoluble amyloid β and C-terminal fragment of amyloid precursor protein which was not mediated by erinacine S. We further performed a long term administration of erinacine A and found that erinacine A recovered the impairment in the tasks including burrowing, nesting, and Morris water maze. Our data pointed out that although both erinacine A and S reduce AD pathology via reducing amyloid deposition and promoting neurogenesis, erinacine A can also inhibit amyloid β production and is worth to be further developed for AD therapeutic use.

  8. Treasures of the Southern Sky

    CERN Document Server

    Gendler, Robert; Malin, David

    2011-01-01

    In these pages, the reader can follow the engaging saga of astronomical exploration in the southern hemisphere, in a modern merger of aesthetics, science, and a story of human endeavor. This book is truly a celebration of southern skies.  Jerry Bonnell, Editor - Astronomy Picture of the Day The southern sky became accessible to scientific scrutiny only a few centuries ago, after the first European explorers ventured south of the equator. Modern observing and imaging techniques have since revealed what seems like a new Universe, previously hidden below the horizon, a fresh astronomical bounty of beauty and knowledge uniquely different from the northern sky. The authors have crafted a book that brings this hidden Universe to all, regardless of location or latitude. Treasures of the Southern Sky celebrates the remarkable beauty and richness of the southern sky in words and with world-class imagery. In part, a photographic anthology of deep sky wonders south of the celestial equator, this book also celebrates th...

  9. Infrared Sky Imager (IRSI) Instrument Handbook

    Energy Technology Data Exchange (ETDEWEB)

    Morris, Victor R. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2016-04-01

    The Infrared Sky Imager (IRSI) deployed at the Atmospheric Radiation Measurement (ARM) Climate Research Facility is a Solmirus Corp. All Sky Infrared Visible Analyzer. The IRSI is an automatic, continuously operating, digital imaging and software system designed to capture hemispheric sky images and provide time series retrievals of fractional sky cover during both the day and night. The instrument provides diurnal, radiometrically calibrated sky imagery in the mid-infrared atmospheric window and imagery in the visible wavelengths for cloud retrievals during daylight hours. The software automatically identifies cloudy and clear regions at user-defined intervals and calculates fractional sky cover, providing a real-time display of sky conditions.

  10. Dark Sky Protection and Education - Izera Dark Sky Park

    Science.gov (United States)

    Berlicki, Arkadiusz; Kolomanski, Sylwester; Mrozek, Tomasz; Zakowicz, Grzegorz

    2015-08-01

    Darkness of the night sky is a natural component of our environment and should be protected against negative effects of human activities. The night darkness is necessary for balanced life of plants, animals and people. Unfortunately, development of human civilization and technology has led to the substantial increase of the night-sky brightness and to situation where nights are no more dark in many areas of the World. This phenomenon is called "light pollution" and it can be rank among such problems as chemical pollution of air, water and soil. Besides the environment, the light pollution can also affect e.g. the scientific activities of astronomers - many observatories built in the past began to be located within the glow of city lights making the night observations difficult, or even impossible.In order to protect the natural darkness of nights many so-called "dark sky parks" were established, where the darkness is preserved, similar to typical nature reserves. The role of these parks is not only conservation but also education, supporting to make society aware of how serious the problem of the light pollution is.History of the dark sky areas in Europe began on November 4, 2009 in Jizerka - a small village situated in the Izera Mountains, when Izera Dark Sky Park (IDSP) was established - it was the first transboundary dark sky park in the World. The idea of establishing that dark sky park in the Izera Mountains originated from a need to give to the society in Poland and Czech Republic the knowledge about the light pollution. Izera Dark Sky Park is a part of the astro-tourism project "Astro Izery" that combines tourist attraction of Izera Valley and astronomical education under the wonderful starry Izera sky. Besides the IDSP, the project Astro Izery consists of the set of simple astronomical instruments (gnomon, sundial), natural educational trail "Solar System Model", and astronomical events for the public. In addition, twice a year we organize a 3-4 days

  11. Dark Skies are a Universal Resource. So are Quiet Skies!

    Science.gov (United States)

    Maddalena, Ronald J.; Heatherly, S.

    2008-05-01

    You've just purchased your first telescope. But where to set it up? Certainly not a WalMart parking lot. Too much light pollution! In the same way that man-made light obscures our night sky and blinds ground-based optical telescopes, man-made radio signals blind radio telescopes as well. NRAO developed the Quiet Skies project to increase awareness of radio frequency interference (RFI) and radio astronomy in general by engaging students in local studies of RFI. To do that we created a sensitive detector which measures RFI. We produced 20 of these, and assembled kits containing detectors and supplementary materials for loan to schools. Students conduct experiments to measure the properties of RFI in their area, and input their measurements into a web-based data base. The Quiet Skies project is a perfect complement to the IYA Dark Skies Awareness initiative. We hope to place 500 Quiet Skies detectors into the field through outreach to museums and schools around the world. Should we be successful, we will sustain this global initiative via a continuing loan program. One day we hope to have a publicly generated image of the Earth which shows RFI much as the Earth at Night image illustrates light pollution. The poster will present the components of the project in detail, including our plans for IYA, and various low-cost alternative strategies for introducing RFI and radio astronomy to the public. We will share the results of some of the experiments already being performed by high school students. Development of the Quiet Skies project was funded by a NASA IDEAS grant. The National Radio Astronomy Observatory is a facility of the National Science Foundation, operated under cooperative agreement by Associated Universities, Inc.

  12. How do Bacteria Adapt to the Red Sea? Cultivation and Genomic and Physiological Characterization of Oligotrophic Bacteria of the PS1, OM43, and SAR11 Clades

    KAUST Repository

    Jimenez Infante, Francy M.

    2015-05-01

    Given the high salinity, prevailing annual high temperatures, and ultra-oligotrophic conditions in the Red Sea isolation and characterization of important microbial groups thriving in this environment is important in understanding the ecological significance and metabolic capabilities of these communities. By using a high-­throughput cultivation technique in natural seawater amended with minute amounts of nutrients, members of the rare biosphere (PS1), methylotrophic Betaproteobacteria (OM43), and the ubiquitous and abundant SAR11 group (Pelagibacterales), were isolated in pure culture. Phylogenetic analyses of Red Sea isolates along with comparative genomics with close representatives from disparate provinces revealed ecotypes and genomic differentiation among the groups. Firstly, the PS1 alphaproteobacterial clade was found to be present in very low abundance in several metagenomic datasets form divergent environments. While strain RS24 (Red Sea) harbored genomic islands involved in polymer degradation, IMCC14465 (East (Japan) Sea) contained unique genes for degradation of aromatic compounds. Secondly, methylotrophic OM43 bacteria from the Red Sea (F5, G12 and H7) showed higher similarities with KB13 isolate from Hawaii, forming a ‘H-­RS’ (Hawaii-­Red Sea) cluster separate from HTCC2181 (Oregon isolate). HTCC2181 members were shown to prevail in cold, productive coastal environments and had an nqrA-­F system for energy generation by sodium motive force. On the contrary, H-­RS cluster members may be better adapted to warm and oligotrophic environments, and seem to generate energy by using a proton-­translocating NADH:Quinone oxidoreductase (complex I; nuoA-­N subunits). Moreover, F5, G12, and H7 had unique proteins related to resistance to UV, temperature and salinity, in addition to a heavy metal ‘resistance island’ as adaptive traits to cope with the environmental conditions in the Red Sea. Finally, description of the Red Sea Pelagibacterales

  13. Upregulation of TREM2 Ameliorates Neuroinflammatory Responses and Improves Cognitive Deficits Triggered by Surgical Trauma in Appswe/PS1dE9 Mice

    Directory of Open Access Journals (Sweden)

    Yanhua Jiang

    2018-04-01

    Full Text Available Background/Aims: TREM2 plays a crucial role in modulating microglial function through interaction with DAP12, the adapter for TREM2. Emerging evidence has demonstrated that TREM2 could suppress neuroinflammatory responses by repression of microglia-mediated cytokine production. This study investigated the potential role of TREM2 in surgery-induced cognitive deficits and neuroinflammatory responses in wild-type (WT and APPswe/PS1dE9 mice. Methods: Adult APPswe/PS1dE9 transgenic male mice (a classic transgenic model of Alzheimer’s disease, 3 months old and their age-matched WT mice received intracerebral lentiviral particles encoding the mouse TREM2 gene and then were subjected to partial hepatectomy at 1 month after the lentiviral particle injection. The behavioral changes were evaluated with an open-field test and Morris water maze test on postoperative days 3, 7, and 14. Hippocampal TREM2, DAP12, and interleukin (IL-1β were measured at each time point. Ionized calcium-binding adapter molecule 1 (Iba-1, microglial M2 phenotype marker Arg1, synaptophysin, tau hyperphosphorylation (T396, and glycogen synthase kinase-3β (GSK-3β were also examined in the hippocampus. Results: Surgical trauma induced an exacerbated cognitive impairment and enhanced hippocampal IL-1β expression in the transgenic mice on postoperative days 3 and 7. A corresponding decline in the levels of TREM2 was also found on postoperative days 3, 7, and 14. Overexpression of TREM2 downregulated the levels of IL-1β, ameliorated T396 expression, inhibited the activity of GSK-3β, and improved sickness behavior. Increased Arg1 expression and a high level of synaptophysin were also observed in the transgenic mice following TREM2 overexpression. Conclusion: The downregulation of TREM2 exacerbated surgery-induced cognitive deficits and exaggerated neuroinflammatory responses in this rodent model. Overexpression of TREM2 potentially attenuated these effects by decreasing the

  14. Early enriched environment exposure protects spatial memory and accelerates amyloid plaque formation in APP(Swe/PS1(L166P mice.

    Directory of Open Access Journals (Sweden)

    Francesca Montarolo

    Full Text Available Enriched environment exposure improves several aspects of cognitive performance in Alzheimer's disease patients and in animal models and, although the role of amyloid plaques is questionable, several studies also assessed their response to enriched environment, with contrasting results. Here we report that rearing APP(Swe/PS1(L166P mice in an enriched environment since birth rescued the spatial memory impairment otherwise present at 6 months of age. At the same time, the exposure to the enriched environment caused a transient acceleration of plaque formation, while there was no effect on intracellular staining with the 6E10 antibody, which recognizes β-amyloid, full length amyloid precursor protein and its C-terminal fragments. The anticipation of plaque formation required exposure during early development, suggesting an action within critical periods for circuits formation. On the other hand, chronic neuronal activity suppression by tetrodotoxin decreased the number of plaques without affecting intracellular amyloid. These results indicate that enriched environment exposure since early life has a protective effect on cognitive deterioration although transiently accelerates amyloid deposition. In addition, the effects of the enriched environment might be due to increased neuronal activity, because plaques were reduced by suppression of electrical signaling by tetrodotoxin.

  15. Dietary DHA supplementation in an APP/PS1 transgenic rat model of AD reduces behavioral and Aβ pathology and modulates Aβ oligomerization.

    Science.gov (United States)

    Teng, Edmond; Taylor, Karen; Bilousova, Tina; Weiland, David; Pham, Thaidan; Zuo, Xiaohong; Yang, Fusheng; Chen, Ping-Ping; Glabe, Charles G; Takacs, Alison; Hoffman, Dennis R; Frautschy, Sally A; Cole, Gregory M

    2015-10-01

    Increased dietary consumption of docosahexaenoic acid (DHA) is associated with decreased risk for Alzheimer's disease (AD). These effects have been postulated to arise from DHA's pleiotropic effects on AD pathophysiology, including its effects on β-amyloid (Aβ) production, aggregation, and toxicity. While in vitro studies suggest that DHA may inhibit and reverse the formation of toxic Aβ oligomers, it remains uncertain whether these mechanisms operate in vivo at the physiological concentrations of DHA attainable through dietary supplementation. We sought to clarify the effects of dietary DHA supplementation on Aβ indices in a transgenic APP/PS1 rat model of AD. Animals maintained on a DHA-supplemented diet exhibited reductions in hippocampal Aβ plaque density and modest improvements on behavioral testing relative to those maintained on a DHA-depleted diet. However, DHA supplementation also increased overall soluble Aβ oligomer levels in the hippocampus. Further quantification of specific conformational populations of Aβ oligomers indicated that DHA supplementation increased fibrillar (i.e. putatively less toxic) Aβ oligomers and decreased prefibrillar (i.e. putatively more toxic) Aβ oligomers. These results provide in vivo evidence suggesting that DHA can modulate Aβ aggregation by stabilizing soluble fibrillar Aβ oligomers and thus reduce the formation of both Aβ plaques and prefibrillar Aβ oligomers. However, since fibrillar Aβ oligomers still retain inherent neurotoxicity, DHA may need to be combined with other interventions that can additionally reduce fibrillar Aβ oligomer levels for more effective prevention of AD in clinical settings. Published by Elsevier Inc.

  16. Neuron and neuroblast numbers and cytogenesis in the dentate gyrus of aged APP(swe)/PS1(dE9) transgenic mice

    DEFF Research Database (Denmark)

    Olesen, Louise Orum; Sivasaravanaparan, Mithula; Severino, Maurizio

    2017-01-01

    Altered neurogenesis may influence hippocampal functions such as learning and memory in Alzheimer's disease. Selective serotonin reuptake inhibitors enhance neurogenesis and have been reported to reduce cerebral amyloidosis in both humans and transgenic mice. We have used stereology to assess the...... working memory, independent of changes in total granular neurons. Furthermore, while long-term paroxetine treatment may be able to reduce hippocampal amyloidosis, it appears to have no effect on total number of granular neurons or spatial working memory....... the longitudinal changes in the number of doublecortin-expressing neuroblasts and number of granular neurons in the dentate gyrus of APPswe/PS1dE9 transgenic mice. Furthermore, we investigated the effect of long-term paroxetine treatment on the number of neuroblasts and granular neurons, hippocampal amyloidosis......Altered neurogenesis may influence hippocampal functions such as learning and memory in Alzheimer's disease. Selective serotonin reuptake inhibitors enhance neurogenesis and have been reported to reduce cerebral amyloidosis in both humans and transgenic mice. We have used stereology to assess...

  17. Erythrocyte membrane-encapsulated celecoxib improves the cognitive decline of Alzheimer's disease by concurrently inducing neurogenesis and reducing apoptosis in APP/PS1 transgenic mice.

    Science.gov (United States)

    Guo, Jing-Wen; Guan, Pei-Pei; Ding, Wei-Yan; Wang, Si-Ling; Huang, Xue-Shi; Wang, Zhan-You; Wang, Pu

    2017-11-01

    Alzheimer's disease (AD) is characterized by the loss of neurogenesis and excessive induction of apoptosis. The induction of neurogenesis and inhibition of apoptosis may be a promising therapeutic approach to combating the disease. Celecoxib (CB), a cyclooxygenase-2 specific inhibitor, could offer neuroprotection. Specifically, the CB-encapsulated erythrocyte membranes (CB-RBCMs) sustained the release of CB over a period of 72 h in vitro and exhibited high brain biodistribution efficiency following intranasal administration, which resulted in the clearance of aggregated β-amyloid proteins (Aβ) in neurons. The high accumulation of the CB-RBCMs in neurons resulted in a decrease in the neurotoxicity of CB and an increase in the migratory activity of neurons, and alleviated cognitive decline in APP/PS1 transgenic (Tg) mice. Indeed, COX-2 metabolic products including prostaglandin E2 (PGE 2 ) and PGD 2 , PGE 2 induced neurogenesis by enhancing the expression of SOD2 and 14-3-3ζ, and PGD 2 stimulated apoptosis by increasing the expression of BIK and decreasing the expression of ARRB1. To this end, the CB-RBCMs achieved better effects on concurrently increasing neurogenesis and decreasing apoptosis than the phospholipid membrane-encapsulated CB liposomes (CB-PSPD-LPs), which are critical for the development and progression of AD. Therefore, CB-RBCMs provide a rational design to treat AD by promoting the self-repairing capacity of the brain. Copyright © 2017 Elsevier Ltd. All rights reserved.

  18. Sphingosine-1-phosphate promotes extravillous trophoblast cell invasion by activating MEK/ERK/MMP-2 signaling pathways via S1P/S1PR1 axis activation.

    Science.gov (United States)

    Yang, Weiwei; Li, Qinghua; Pan, Zhifang

    2014-01-01

    Successful placentation depends on the proper invasion of extravillous trophoblast (EVT) cells into maternal tissues. Previous reports demonstrated that S1P receptors are expressed in the EVT cells and S1P could regulate migration and function of trophoblast cells via S1P receptors. However, little is known about roles of S1P in the invasion of EVT cells. Our study was performed to investigate S1P effect on the invasion of EVT cells. We used the extravillous trophoblast cell line HTR8/SVneo cells to evaluate the effect. In vitro invasion assay was employed to determine the invasion of HTR8/SVneo cells induced by S1P. MMP-2 enzyme activity and relative level in the supernatants of HTR8/SVneo was assessed by gelatin zymography and western blot. Based on the above, siRNA and specific inhibitors were used for the intervention and study of potential signal pathways, and Real-time qPCR and western blot were used to test the mRNA and protein level of potential signal targets. We found that S1P could promote HTR8/SVneo cell invasion and upregulates activity and level of MMP-2. The promotion requires activation of MEK-ERK and is dependent on the axis of S1P/S1PR1. Our investigation of S1P may provide new insights into the molecular mechanisms of EVT invasion.

  19. Downregulation of PI3K/Akt/mTOR signaling pathway in curcumin-induced autophagy in APP/PS1 double transgenic mice.

    Science.gov (United States)

    Wang, Chen; Zhang, Xiong; Teng, Zhipeng; Zhang, Tong; Li, Yu

    2014-10-05

    Autophagy is a lysosomal degradation pathway, which is essential for cell survival, proliferation, differentiation and homeostasis. It is well known that beta-amyloid (Aβ) aggregation is one of key characteristics for Alzheimer's disease (AD), which triggers a complex pathological cascade, leading to neurodegeneration. Recent studies have shown that Aβ peptide is generated from amyloid β precursor protein (APP) during autophagic turnover of APP-rich organelles by autophagy. Aβ generation during normal autophagy is subsequently degraded by lysosomes. Curcumin, a nature plant extraction, has been reported to inhibit the generation and deposition of Aβ; however, the underlying mechanisms are not fully understood yet. In the present study, we reported that curcumin treatment not only attenuated cognitive impairment detected by Morris water maze test, but also inhibited the generation of Aβ investigated by immunohistochemistry in APP/PS1 double transgenic AD mice. Moreover, curcumin induced autophagy in the mice, evidenced by LC3 immunofluorescence analysis and western blot assays on LC3. Furthermore, we found that curcumin significantly decreased the expression of Phosphatidylinositol 3-Kinase (PI3K), phosphorylated Akt and rapamycin (mTOR) at protein levels, respectively. Taken together, our data suggests that curcumin inhibits Aβ generation and induces of autophagy by downregulating PI3K/Akt/mTOR signaling pathway, and further shows a neuroprotective effect. Meanwhile curcumin might be a candidate neuroprotective agent for AD patients treatment by inducing autophagy. Copyright © 2014 Elsevier B.V. All rights reserved.

  20. Activation of nicotinic α(7) acetylcholine receptor enhances long term potentation in wild type mice but not in APP(swe)/PS1ΔE9 mice

    DEFF Research Database (Denmark)

    Söderman, Andreas; Mikkelsen, Jens D; West, Mark J

    2011-01-01

    the effect of the partial α(7) nAChR agonist SSR180711 on hippocampal slice preparations from normal wild type (Wt) and APP(swe)/PS1ΔE9 transgenic (Tg) mice. In the hippocampal slices from the 6 months old Wt mice, the application of both nicotine (5μM) and SSR180711 (300nM) resulted in a significant...... enhancement of LTP expressed in area CA1. However, in the Tg mice the application of SSR180711 did not result in an increase in LTP beyond control levels. The amount of binding of the α(7) nAChR ligand 125-I-α-bungarotoxin was not different between in Tg and Wt mice. These findings indicate that the α(7) n......AChR is functionally blocked in the hippocampal neurons, downstream of the α(7) nAChR, and that this is likely due to an interaction between the receptor and Aβ, which leads to changes in LTP....

  1. Liraglutide Improves Water Maze Learning and Memory Performance While Reduces Hyperphosphorylation of Tau and Neurofilaments in APP/PS1/Tau Triple Transgenic Mice.

    Science.gov (United States)

    Chen, Shuyi; Sun, Jie; Zhao, Gang; Guo, Ai; Chen, Yanlin; Fu, Rongxia; Deng, Yanqiu

    2017-08-01

    The purpose of this study was to explore how liraglutide affects AD-like pathology and cognitive function in APP/PS1/Tau triple transgenic (3 × Tg) Alzheimer disease (AD) model mice. Male 3 × Tg mice and C57BL/6 J mice were treated for 8 weeks with liraglutide (300 μg/kg/day, subcutaneous injection) or saline. Levels of phosphorylated tau, neurofilaments (NFs), extracellular signal-regulated kinase (ERK), and c-Jun N-terminal kinase (JNK) in brain tissues were assessed with western blots. Fluoro-Jade-B labeling were applied to detect pathological changes. The Morris water maze (MWM) was used to assess the spatial learning and memory. Liraglutide decreased levels of hyperphosphorylated tau and NFs in 3 × Tg liraglutide-treated (Tg + LIR) mice, increased ERK phosphorylation, and decreased JNK phosphorylation. Liraglutide also decreased the number of degenerative neurons in the hippocampus and cortex of Tg + LIR mice, and shortened their escape latencies and increased their hidden platform crossings in the MWM task. Liraglutide did not significantly affect the animals' body weight (BW) or fasting blood glucose. Liraglutide can reduce hyperphosphorylation of tau and NFs and reduce neuronal degeneration, apparently through alterations in JNK and ERK signaling, which may be related to its positive effects on AD-like learning and memory impairment.

  2. Serum β-amyloid peptide levels spike in the early stage of Alzheimer-like plaque pathology in an APP/PS1 double transgenic mouse model.

    Science.gov (United States)

    He, Jue; Qiao, Jin-Ping; Zhu, Shenghua; Xue, Mengzhou; Chen, Wenwu; Wang, Xinchun; Tempier, Adrien; Huang, Qingjun; Kong, Jiming; Li, Xin-Min

    2013-11-01

    Serum levels of β-amyloid (Aβ) peptides may represent an early biomarker in the diagnosis of Alzheimer's disease (AD). In the present study, we investigated the temporal kinetic changes in the levels of serum Aβ 1-42 and 40 in an amyloid precursor protein (APP)/presenilin (PS)1 double transgenic mouse model of AD. Serum Aβ peptide levels in 2-, 3-, 6-, 9- and 18-month old, and liver Aβ 1-40 level in 6-month old mice were measured using enzyme-linked immunosorbent assay (ELISA) kits. Results revealed that serum Aβ levels peaked in 3-month old transgenic mice, and the Aβ level in non-transgenic and transgenic mice is comparable in liver. Compared to the 6-month old transgenic mice, Congo red staining showed that the 3-month old transgenic mice had minimum brain Aβ plaques, corresponding to the early stage of Alzheimer-like plaque pathology, and confocal microscope images showed that the deposition of Aβ in their cerebral vessels was minimal. Furthermore, results of the water maze test, showed that memory was normal for the 3- month old transgenic mice when compared to age-matched non-transgenic mice. These results suggest that serum Aβ peptide levels may be peaked during the early stage of AD. Monitoring serum Aβ peptide levels in the potential AD population may provide an early diagnosis of AD prior to the appearance of clinical symptoms.

  3. Chronic caffeine treatment reverses memory impairment and the expression of brain BNDF and TrkB in the PS1/APP double transgenic mouse model of Alzheimer?s disease

    OpenAIRE

    HAN, KUN; JIA, NING; LI, JI; YANG, LI; MIN, LIAN-QIU

    2013-01-01

    The objective of this study was to investigate the effects of varying doses of caffeine on memory impairment and the expression of brain neurotrophic derived factor (BNDF) and TrkB in PS1/APP double transgenic mouse models. PS1/APP double transgenic mice were administered 0.3 ml/day of saline, 1.5 mg/day of caffeine or 0.75 mg/day of caffeine for eight weeks. A water maze test and western blotting were used to determine the memory capability and expression of hippocampal BNDF and TrkB of the ...

  4. The "All Sky Camera Network"

    Science.gov (United States)

    Caldwell, Andy

    2005-01-01

    In 2001, the "All Sky Camera Network" came to life as an outreach program to connect the Denver Museum of Nature and Science (DMNS) exhibit "Space Odyssey" with Colorado schools. The network is comprised of cameras placed strategically at schools throughout Colorado to capture fireballs--rare events that produce meteorites.…

  5. Deep-Sky Video Astronomy

    CERN Document Server

    Massey, Steve

    2009-01-01

    A guide to using modern integrating video cameras for deep-sky viewing and imaging with the kinds of modest telescopes available commercially to amateur astronomers. It includes an introduction and a brief history of the technology and camera types. It examines the pros and cons of this unrefrigerated yet highly efficient technology

  6. Education for Life in the Sky.

    Science.gov (United States)

    Roth, Charles E.

    1981-01-01

    The need to educate people about the sky as both a psychological and physical environment is discussed, including a formal curriculum schema (sky as habitat, sky as transport, influence on culture) and informal curriculum, with such topics as recreation, pollution, mythology, and clouds. (DC)

  7. Synaptic plasticity in the hippocampus of a APP/PS1 mouse model of Alzheimer's disease is impaired in old but not young mice.

    Directory of Open Access Journals (Sweden)

    Simon Gengler

    Full Text Available BACKGROUND: Alzheimer disease (AD is a neurodegenerative disorder for which there is no cure. We have investigated synaptic plasticity in area CA1 in a novel AD mouse model (APPPS1-21 which expresses the Swedish mutation of APP and the L166P mutation of human PS-1. This model shows initial plaque formation at 2 months in the neocortex and 4 months in the hippocampus and displays beta-amyloid-associated pathologies and learning impairments. METHODOLOGY/PRINCIPAL FINDINGS: We tested long-term potentiation (LTP and short term potentiation (paired-pulse facilitation, PPF of synaptic transmission in vivo in area CA1 of the hippocampus. There was no difference in LTP or PPF at 4-5 months of age in APPPS1-21 mice compared to littermate controls. At 6 months of age there was also no difference in LTP but APPPS1-21 mice showed slightly increased PPF (p<0.03. In 8 months old mice, LTP was greatly impaired in APPPS-21 animals (p<0.0001 while PPF was not changed. At 15 months of age, APPPS1-21 mice showed again impaired LTP compared to littermate controls (p<0.005, and PPF was also significantly reduced at 80 ms (p<0.005 and 160 ms (p<0.01 interstimulus interval. Immunohistological analysis showed only modest amyloid deposition in the hippocampus at 4 and 6 months with a robust increase up to 15 months of age. CONCLUSIONS: Our results suggest that increased formation and aggregation of beta amyloid with aging is responsible for the impaired LTP with aging in this mouse model, while the transient increase of PPF at 6 months of age is caused by some other mechanism.

  8. Transplantation of in vitro cultured endothelial progenitor cells repairs the blood-brain barrier and improves cognitive function of APP/PS1 transgenic AD mice.

    Science.gov (United States)

    Zhang, Shishuang; Zhi, Yongle; Li, Fei; Huang, Shan; Gao, Huabin; Han, Zhaoli; Ge, Xintong; Li, Dai; Chen, Fanglian; Kong, Xiaodong; Lei, Ping

    2018-04-15

    To date, the pathogenesis of Alzheimer's disease (AD) remains unclear. It is well-known that excessive deposition of Aβ in the brain is a crucial part of the pathogenesis of AD. In recent years, the AD neurovascular unit hypothesis has attracted much attention. Impairment of the blood-brain barrier (BBB) leads to abnormal amyloid-β (Aβ) transport, and chronic cerebral hypoperfusion causes Aβ deposition throughout the onset and progression of AD. Endothelial progenitor cells (EPCs) are the universal cells for repairing blood vessels. Our previous studies have shown that a reduced number of EPCs in the peripheral blood results in cerebral vascular repair disorder, cerebral hypoperfusion and neurodegeneration, which might be related to the cognitive dysfunction of AD patients. This study was designed to confirm whether EPCs transplantation could repair the blood-brain barrier, stimulate angiogenesis and reduce Aβ deposition in AD. The expression of ZO-1, Occludin and Claudin-5 was up-regulated in APP/PS1 transgenic mice after hippocampal transplantation of EPCs. Consistent with previous studies, EPC transplants also increased the microvessel density. We observed that Aβ senile plaque deposition was decreased and hippocampal cell apoptosis was reduced after EPCs transplantation. The Morris water maze test showed that spatial learning and memory functions were significantly improved in mice transplanted with EPCs. Consequently, EPCs could up-regulate the expression of tight junction proteins, repair BBB tight junction function, stimulate angiogenesis, promote Aβ clearance, and decrease neuronal loss, ultimately improve cognitive function. Taken together, these data demonstrate EPCs may play an important role in the therapeutic implications for vascular dysfunction in AD. Copyright © 2018 Elsevier B.V. All rights reserved.

  9. A role of the sphingosine-1-phosphate (S1P)-S1P receptor 2 pathway in epithelial defense against cancer (EDAC).

    Science.gov (United States)

    Yamamoto, Sayaka; Yako, Yuta; Fujioka, Yoichiro; Kajita, Mihoko; Kameyama, Takeshi; Kon, Shunsuke; Ishikawa, Susumu; Ohba, Yusuke; Ohno, Yusuke; Kihara, Akio; Fujita, Yasuyuki

    2016-02-01

    At the initial step of carcinogenesis, transformation occurs in single cells within epithelia, where the newly emerging transformed cells are surrounded by normal epithelial cells. A recent study revealed that normal epithelial cells have an ability to sense and actively eliminate the neighboring transformed cells, a process named epithelial defense against cancer (EDAC). However, the molecular mechanism of this tumor-suppressive activity is largely unknown. In this study, we investigated a role for the sphingosine-1-phosphate (S1P)-S1P receptor 2 (S1PR2) pathway in EDAC. First, we show that addition of the S1PR2 inhibitor significantly suppresses apical extrusion of RasV12-transformed cells that are surrounded by normal cells. In addition, knockdown of S1PR2 in normal cells induces the same effect, indicating that S1PR2 in the surrounding normal cells plays a positive role in the apical elimination of the transformed cells. Of importance, not endogenous S1P but exogenous S1P is involved in this process. By using FRET analyses, we demonstrate that S1PR2 mediates Rho activation in normal cells neighboring RasV12-transformed cells, thereby promoting accumulation of filamin, a crucial regulator of EDAC. Collectively these data indicate that S1P is a key extrinsic factor that affects the outcome of cell competition between normal and transformed epithelial cells. © 2016 Yamamoto, Yako, et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

  10. Suppressed retinal degeneration in aged wild type and APPswe/PS1ΔE9 mice by bone marrow transplantation.

    Directory of Open Access Journals (Sweden)

    Yue Yang

    Full Text Available Alzheimer's disease (AD is an age-related condition characterized by accumulation of neurotoxic amyloid β peptides (Aβ in brain and retina. Because bone marrow transplantation (BMT results in decreased cerebral Aβ in experimental AD, we hypothesized that BMT would mitigate retinal neurotoxicity through decreased retinal Aβ. To test this, we performed BMT in APPswe/PS1ΔE9 double transgenic mice using green fluorescent protein expressing wild type (wt mice as marrow donors. We first examined retinas from control, non-transplanted, aged AD mice and found a two-fold increase in microglia compared with wt mice, prominent inner retinal Aβ and paired helical filament-tau, and decreased retinal ganglion cell layer neurons. BMT resulted in near complete replacement of host retinal microglia with BMT-derived cells and normalized total AD retinal microglia to non-transplanted wt levels. Aβ and paired helical filament-tau were reduced (61.0% and 44.1% respectively in BMT-recipient AD mice, which had 20.8% more retinal ganglion cell layer neurons than non-transplanted AD controls. Interestingly, aged wt BMT recipients also had significantly more neurons (25.4% compared with non-transplanted aged wt controls. Quantitation of retinal ganglion cell layer neurons in young mice confirmed age-related retinal degeneration was mitigated by BMT. We found increased MHC class II expression in BMT-derived microglia and decreased oxidative damage in retinal ganglion cell layer neurons. Thus, BMT is neuroprotective in age-related as well as AD-related retinal degeneration, and may be a result of alterations in innate immune function and oxidative stress in BMT recipient mice.

  11. THE SLOAN DIGITAL SKY SURVEY REVERBERATION MAPPING PROJECT: TECHNICAL OVERVIEW

    Energy Technology Data Exchange (ETDEWEB)

    Shen, Yue [Carnegie Observatories, 813 Santa Barbara Street, Pasadena, CA 91101 (United States); Brandt, W. N. [Department of Astronomy and Astrophysics, The Pennsylvania State University, University Park, PA 16802 (United States); Dawson, Kyle S. [Department of Physics and Astronomy, University of Utah, 115 South 1400 East, Salt Lake City, UT 84112 (United States); Hall, Patrick B. [Department of Physics and Astronomy, York University, Toronto, ON M3J 1P3 (Canada); McGreer, Ian D.; Fan, Xiaohui [Steward Observatory, The University of Arizona, 933 North Cherry Avenue, Tucson, AZ 85721-0065 (United States); Anderson, Scott F. [Astronomy Department, University of Washington, Box 351580, Seattle, WA 98195 (United States); Chen, Yuguang [Department of Astronomy, School of Physics, Peking University, Beijing 100871 (China); Denney, Kelly D. [Department of Astronomy, The Ohio State University, 140 West 18th Avenue, Columbus, OH 43210 (United States); Eftekharzadeh, Sarah [Department of Physics and Astronomy, University of Wyoming, 1000 East University Avenue, Laramie, WY 82071 (United States); Gao, Yang [Department of Engineering Physics and Center for Astrophysics, Tsinghua University, Beijing 100084 (China); Green, Paul J. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Greene, Jenny E. [Department of Astrophysical Sciences, Princeton University, Princeton, NJ 08544 (United States); Ho, Luis C. [Kavli Institute for Astronomy and Astrophysics, Peking University, Beijing 100871 (China); Horne, Keith [SUPA Physics/Astronomy, University of St. Andrews, St. Andrews KY16 9SS (United Kingdom); Jiang, Linhua [School of Earth and Space Exploration, Arizona State University, Tempe, AZ 85287-1504 (United States); Kelly, Brandon C. [Department of Physics, Broida Hall, University of California, Santa Barbara, CA 93107 (United States); and others

    2015-01-01

    The Sloan Digital Sky Survey Reverberation Mapping (SDSS-RM) project is a dedicated multi-object RM experiment that has spectroscopically monitored a sample of 849 broad-line quasars in a single 7 deg{sup 2} field with the SDSS-III Baryon Oscillation Spectroscopic Survey spectrograph. The RM quasar sample is flux-limited to i {sub psf} = 21.7 mag, and covers a redshift range of 0.1 < z < 4.5 without any other cuts on quasar properties. Optical spectroscopy was performed during 2014 January-July dark/gray time, with an average cadence of ∼4 days, totaling more than 30 epochs. Supporting photometric monitoring in the g and i bands was conducted at multiple facilities including the Canada-France-Hawaii Telescope (CFHT) and the Steward Observatory Bok telescope in 2014, with a cadence of ∼2 days and covering all lunar phases. The RM field (R.A., decl. = 14:14:49.00, +53:05:00.0) lies within the CFHT-LS W3 field, and coincides with the Pan-STARRS 1 (PS1) Medium Deep Field MD07, with three prior years of multi-band PS1 light curves. The SDSS-RM six month baseline program aims to detect time lags between the quasar continuum and broad line region (BLR) variability on timescales of up to several months (in the observed frame) for ∼10% of the sample, and to anchor the time baseline for continued monitoring in the future to detect lags on longer timescales and at higher redshift. SDSS-RM is the first major program to systematically explore the potential of RM for broad-line quasars at z > 0.3, and will investigate the prospects of RM with all major broad lines covered in optical spectroscopy. SDSS-RM will provide guidance on future multi-object RM campaigns on larger scales, and is aiming to deliver more than tens of BLR lag detections for a homogeneous sample of quasars. We describe the motivation, design, and implementation of this program, and outline the science impact expected from the resulting data for RM and general quasar science.

  12. THE SLOAN DIGITAL SKY SURVEY REVERBERATION MAPPING PROJECT: TECHNICAL OVERVIEW

    International Nuclear Information System (INIS)

    Shen, Yue; Brandt, W. N.; Dawson, Kyle S.; Hall, Patrick B.; McGreer, Ian D.; Fan, Xiaohui; Anderson, Scott F.; Chen, Yuguang; Denney, Kelly D.; Eftekharzadeh, Sarah; Gao, Yang; Green, Paul J.; Greene, Jenny E.; Ho, Luis C.; Horne, Keith; Jiang, Linhua; Kelly, Brandon C.

    2015-01-01

    The Sloan Digital Sky Survey Reverberation Mapping (SDSS-RM) project is a dedicated multi-object RM experiment that has spectroscopically monitored a sample of 849 broad-line quasars in a single 7 deg 2 field with the SDSS-III Baryon Oscillation Spectroscopic Survey spectrograph. The RM quasar sample is flux-limited to i psf = 21.7 mag, and covers a redshift range of 0.1 < z < 4.5 without any other cuts on quasar properties. Optical spectroscopy was performed during 2014 January-July dark/gray time, with an average cadence of ∼4 days, totaling more than 30 epochs. Supporting photometric monitoring in the g and i bands was conducted at multiple facilities including the Canada-France-Hawaii Telescope (CFHT) and the Steward Observatory Bok telescope in 2014, with a cadence of ∼2 days and covering all lunar phases. The RM field (R.A., decl. = 14:14:49.00, +53:05:00.0) lies within the CFHT-LS W3 field, and coincides with the Pan-STARRS 1 (PS1) Medium Deep Field MD07, with three prior years of multi-band PS1 light curves. The SDSS-RM six month baseline program aims to detect time lags between the quasar continuum and broad line region (BLR) variability on timescales of up to several months (in the observed frame) for ∼10% of the sample, and to anchor the time baseline for continued monitoring in the future to detect lags on longer timescales and at higher redshift. SDSS-RM is the first major program to systematically explore the potential of RM for broad-line quasars at z > 0.3, and will investigate the prospects of RM with all major broad lines covered in optical spectroscopy. SDSS-RM will provide guidance on future multi-object RM campaigns on larger scales, and is aiming to deliver more than tens of BLR lag detections for a homogeneous sample of quasars. We describe the motivation, design, and implementation of this program, and outline the science impact expected from the resulting data for RM and general quasar science

  13. Observation of $B^+\\rightarrow J/\\psi 3\\pi^+ 2\\pi^-$ and $B^+\\rightarrow \\psi(2S) \\pi^+\\pi^+\\pi^-$ decays

    CERN Document Server

    Aaij, Roel; Adinolfi, Marco; Ajaltouni, Ziad; Akar, Simon; Albrecht, Johannes; Alessio, Federico; Alexander, Michael; Ali, Suvayu; Alkhazov, Georgy; Alvarez Cartelle, Paula; Alves Jr, Antonio Augusto; Amato, Sandra; Amerio, Silvia; Amhis, Yasmine; An, Liupan; Anderlini, Lucio; Andreassi, Guido; Andreotti, Mirco; Andrews, Jason; Appleby, Robert; Archilli, Flavio; d'Argent, Philippe; Arnau Romeu, Joan; Artamonov, Alexander; Artuso, Marina; Aslanides, Elie; Auriemma, Giulio; Baalouch, Marouen; Babuschkin, Igor; Bachmann, Sebastian; Back, John; Badalov, Alexey; Baesso, Clarissa; Baker, Sophie; Baldini, Wander; Barlow, Roger; Barschel, Colin; Barsuk, Sergey; Barter, William; Baszczyk, Mateusz; Batozskaya, Varvara; Batsukh, Baasansuren; Battista, Vincenzo; Bay, Aurelio; Beaucourt, Leo; Beddow, John; Bedeschi, Franco; Bediaga, Ignacio; Bel, Lennaert; Bellee, Violaine; Belloli, Nicoletta; Belous, Konstantin; Belyaev, Ivan; Ben-Haim, Eli; Bencivenni, Giovanni; Benson, Sean; Benton, Jack; Berezhnoy, Alexander; Bernet, Roland; Bertolin, Alessandro; Betancourt, Christopher; Betti, Federico; Bettler, Marc-Olivier; van Beuzekom, Martinus; Bezshyiko, Iaroslava; Bifani, Simone; Billoir, Pierre; Bird, Thomas; Birnkraut, Alex; Bitadze, Alexander; Bizzeti, Andrea; Blake, Thomas; Blanc, Frederic; Blouw, Johan; Blusk, Steven; Bocci, Valerio; Boettcher, Thomas; Bondar, Alexander; Bondar, Nikolay; Bonivento, Walter; Bordyuzhin, Igor; Borgheresi, Alessio; Borghi, Silvia; Borisyak, Maxim; Borsato, Martino; Bossu, Francesco; Boubdir, Meriem; Bowcock, Themistocles; Bowen, Espen Eie; Bozzi, Concezio; Braun, Svende; Britsch, Markward; Britton, Thomas; Brodzicka, Jolanta; Buchanan, Emma; Burr, Christopher; Bursche, Albert; Buytaert, Jan; Cadeddu, Sandro; Calabrese, Roberto; Calvi, Marta; Calvo Gomez, Miriam; Camboni, Alessandro; Campana, Pierluigi; Campora Perez, Daniel Hugo; Capriotti, Lorenzo; Carbone, Angelo; Carboni, Giovanni; Cardinale, Roberta; Cardini, Alessandro; Carniti, Paolo; Carson, Laurence; Carvalho Akiba, Kazuyoshi; Casse, Gianluigi; Cassina, Lorenzo; Castillo Garcia, Lucia; Cattaneo, Marco; Cauet, Christophe; Cavallero, Giovanni; Cenci, Riccardo; Charles, Matthew; Charpentier, Philippe; Chatzikonstantinidis, Georgios; Chefdeville, Maximilien; Chen, Shanzhen; Cheung, Shu-Faye; Chobanova, Veronika; Chrzaszcz, Marcin; Cid Vidal, Xabier; Ciezarek, Gregory; Clarke, Peter; Clemencic, Marco; Cliff, Harry; Closier, Joel; Coco, Victor; Cogan, Julien; Cogneras, Eric; Cogoni, Violetta; Cojocariu, Lucian; Collazuol, Gianmaria; Collins, Paula; Comerma-Montells, Albert; Contu, Andrea; Cook, Andrew; Coombs, George; Coquereau, Samuel; Corti, Gloria; Corvo, Marco; Costa Sobral, Cayo Mar; Couturier, Benjamin; Cowan, Greig; Craik, Daniel Charles; Crocombe, Andrew; Cruz Torres, Melissa Maria; Cunliffe, Samuel; Currie, Robert; D'Ambrosio, Carmelo; Da Cunha Marinho, Franciole; Dall'Occo, Elena; Dalseno, Jeremy; David, Pieter; Davis, Adam; De Aguiar Francisco, Oscar; De Bruyn, Kristof; De Capua, Stefano; De Cian, Michel; De Miranda, Jussara; De Paula, Leandro; De Serio, Marilisa; De Simone, Patrizia; Dean, Cameron Thomas; Decamp, Daniel; Deckenhoff, Mirko; Del Buono, Luigi; Demmer, Moritz; Dendek, Adam; Derkach, Denis; Deschamps, Olivier; Dettori, Francesco; Dey, Biplab; Di Canto, Angelo; Dijkstra, Hans; Dordei, Francesca; Dorigo, Mirco; Dosil Suárez, Alvaro; Dovbnya, Anatoliy; Dreimanis, Karlis; Dufour, Laurent; Dujany, Giulio; Dungs, Kevin; Durante, Paolo; Dzhelyadin, Rustem; Dziurda, Agnieszka; Dzyuba, Alexey; Déléage, Nicolas; Easo, Sajan; Ebert, Marcus; Egede, Ulrik; Egorychev, Victor; Eidelman, Semen; Eisenhardt, Stephan; Eitschberger, Ulrich; Ekelhof, Robert; Eklund, Lars; Ely, Scott; Esen, Sevda; Evans, Hannah Mary; Evans, Timothy; Falabella, Antonio; Farley, Nathanael; Farry, Stephen; Fay, Robert; Fazzini, Davide; Ferguson, Dianne; Fernandez Prieto, Antonio; Ferrari, Fabio; Ferreira Rodrigues, Fernando; Ferro-Luzzi, Massimiliano; Filippov, Sergey; Fini, Rosa Anna; Fiore, Marco; Fiorini, Massimiliano; Firlej, Miroslaw; Fitzpatrick, Conor; Fiutowski, Tomasz; Fleuret, Frederic; Fohl, Klaus; Fontana, Marianna; Fontanelli, Flavio; Forshaw, Dean Charles; Forty, Roger; Franco Lima, Vinicius; Frank, Markus; Frei, Christoph; Fu, Jinlin; Furfaro, Emiliano; Färber, Christian; Gallas Torreira, Abraham; Galli, Domenico; Gallorini, Stefano; Gambetta, Silvia; Gandelman, Miriam; Gandini, Paolo; Gao, Yuanning; Garcia Martin, Luis Miguel; García Pardiñas, Julián; Garra Tico, Jordi; Garrido, Lluis; Garsed, Philip John; Gascon, David; Gaspar, Clara; Gavardi, Laura; Gazzoni, Giulio; Gerick, David; Gersabeck, Evelina; Gersabeck, Marco; Gershon, Timothy; Ghez, Philippe; Gianì, Sebastiana; Gibson, Valerie; Girard, Olivier Göran; Giubega, Lavinia-Helena; Gizdov, Konstantin; Gligorov, V.V.; Golubkov, Dmitry; Golutvin, Andrey; Gomes, Alvaro; Gorelov, Igor Vladimirovich; Gotti, Claudio; Govorkova, Ekaterina; Grabalosa Gándara, Marc; Graciani Diaz, Ricardo; Granado Cardoso, Luis Alberto; Graugés, Eugeni; Graverini, Elena; Graziani, Giacomo; Grecu, Alexandru; Griffith, Peter; Grillo, Lucia; Gruberg Cazon, Barak Raimond; Grünberg, Oliver; Gushchin, Evgeny; Guz, Yury; Gys, Thierry; Göbel, Carla; Hadavizadeh, Thomas; Hadjivasiliou, Christos; Haefeli, Guido; Haen, Christophe; Haines, Susan; Hall, Samuel; Hamilton, Brian; Han, Xiaoxue; Hansmann-Menzemer, Stephanie; Harnew, Neville; Harnew, Samuel; Harrison, Jonathan; Hatch, Mark; He, Jibo; Head, Timothy; Heister, Arno; Hennessy, Karol; Henrard, Pierre; Henry, Louis; Hernando Morata, Jose Angel; van Herwijnen, Eric; Heß, Miriam; Hicheur, Adlène; Hill, Donal; Hombach, Christoph; Hopchev, P H; Hulsbergen, Wouter; Humair, Thibaud; Hushchyn, Mikhail; Hussain, Nazim; Hutchcroft, David; Idzik, Marek; Ilten, Philip; Jacobsson, Richard; Jaeger, Andreas; Jalocha, Pawel; Jans, Eddy; Jawahery, Abolhassan; Jiang, Feng; John, Malcolm; Johnson, Daniel; Jones, Christopher; Joram, Christian; Jost, Beat; Jurik, Nathan; Kandybei, Sergii; Kanso, Walaa; Karacson, Matthias; Kariuki, James Mwangi; Karodia, Sarah; Kecke, Matthieu; Kelsey, Matthew; Kenyon, Ian; Kenzie, Matthew; Ketel, Tjeerd; Khairullin, Egor; Khanji, Basem; Khurewathanakul, Chitsanu; Kirn, Thomas; Klaver, Suzanne; Klimaszewski, Konrad; Koliiev, Serhii; Kolpin, Michael; Komarov, Ilya; Koopman, Rose; Koppenburg, Patrick; Kosmyntseva, Alena; Kozachuk, Anastasiia; Kozeiha, Mohamad; Kravchuk, Leonid; Kreplin, Katharina; Kreps, Michal; Krokovny, Pavel; Kruse, Florian; Krzemien, Wojciech; Kucewicz, Wojciech; Kucharczyk, Marcin; Kudryavtsev, Vasily; Kuonen, Axel Kevin; Kurek, Krzysztof; Kvaratskheliya, Tengiz; Lacarrere, Daniel; Lafferty, George; Lai, Adriano; Lanfranchi, Gaia; Langenbruch, Christoph; Latham, Thomas; Lazzeroni, Cristina; Le Gac, Renaud; van Leerdam, Jeroen; Lees, Jean-Pierre; Leflat, Alexander; Lefrançois, Jacques; Lefèvre, Regis; Lemaitre, Florian; Lemos Cid, Edgar; Leroy, Olivier; Lesiak, Tadeusz; Leverington, Blake; Li, Yiming; Likhomanenko, Tatiana; Lindner, Rolf; Linn, Christian; Lionetto, Federica; Liu, Bo; Liu, Xuesong; Loh, David; Longstaff, Iain; Lopes, Jose; Lucchesi, Donatella; Lucio Martinez, Miriam; Luo, Haofei; Lupato, Anna; Luppi, Eleonora; Lupton, Oliver; Lusiani, Alberto; Lyu, Xiao-Rui; Machefert, Frederic; Maciuc, Florin; Maev, Oleg; Maguire, Kevin; Malde, Sneha; Malinin, Alexander; Maltsev, Timofei; Manca, Giulia; Mancinelli, Giampiero; Manning, Peter Michael; Maratas, Jan; Marchand, Jean François; Marconi, Umberto; Marin Benito, Carla; Marino, Pietro; Marks, Jörg; Martellotti, Giuseppe; Martin, Morgan; Martinelli, Maurizio; Martinez Santos, Diego; Martinez Vidal, Fernando; Martins Tostes, Danielle; Massacrier, Laure Marie; Massafferri, André; Matev, Rosen; Mathad, Abhijit; Mathe, Zoltan; Matteuzzi, Clara; Mauri, Andrea; Maurin, Brice; Mazurov, Alexander; McCann, Michael; McCarthy, James; McNab, Andrew; McNulty, Ronan; Meadows, Brian; Meier, Frank; Meissner, Marco; Melnychuk, Dmytro; Merk, Marcel; Merli, Andrea; Michielin, Emanuele; Milanes, Diego Alejandro; Minard, Marie-Noelle; Mitzel, Dominik Stefan; Mogini, Andrea; Molina Rodriguez, Josue; Monroy, Ignacio Alberto; Monteil, Stephane; Morandin, Mauro; Morawski, Piotr; Mordà, Alessandro; Morello, Michael Joseph; Moron, Jakub; Morris, Adam Benjamin; Mountain, Raymond; Muheim, Franz; Mulder, Mick; Mussini, Manuel; Müller, Dominik; Müller, Janine; Müller, Katharina; Müller, Vanessa; Naik, Paras; Nakada, Tatsuya; Nandakumar, Raja; Nandi, Anita; Nasteva, Irina; Needham, Matthew; Neri, Nicola; Neubert, Sebastian; Neufeld, Niko; Neuner, Max; Nguyen, Anh Duc; Nguyen, Thi Dung; Nguyen-Mau, Chung; Nieswand, Simon; Niet, Ramon; Nikitin, Nikolay; Nikodem, Thomas; Novoselov, Alexey; O'Hanlon, Daniel Patrick; Oblakowska-Mucha, Agnieszka; Obraztsov, Vladimir; Ogilvy, Stephen; Oldeman, Rudolf; Onderwater, Gerco; Otalora Goicochea, Juan Martin; Otto, Adam; Owen, Patrick; Oyanguren, Maria Aranzazu; Pais, Preema Rennee; Palano, Antimo; Palombo, Fernando; Palutan, Matteo; Panman, Jacob; Papanestis, Antonios; Pappagallo, Marco; Pappalardo, Luciano; Parker, William; Parkes, Christopher; Passaleva, Giovanni; Pastore, Alessandra; Patel, Girish; Patel, Mitesh; Patrignani, Claudia; Pearce, Alex; Pellegrino, Antonio; Penso, Gianni; Pepe Altarelli, Monica; Perazzini, Stefano; Perret, Pascal; Pescatore, Luca; Petridis, Konstantinos; Petrolini, Alessandro; Petrov, Aleksandr; Petruzzo, Marco; Picatoste Olloqui, Eduardo; Pietrzyk, Boleslaw; Pikies, Malgorzata; Pinci, Davide; Pistone, Alessandro; Piucci, Alessio; Playfer, Stephen; Plo Casasus, Maximo; Poikela, Tuomas; Polci, Francesco; Poluektov, Anton; Polyakov, Ivan; Polycarpo, Erica; Pomery, Gabriela Johanna; Popov, Alexander; Popov, Dmitry; Popovici, Bogdan; Poslavskii, Stanislav; Potterat, Cédric; Price, Eugenia; Price, Joseph David; Prisciandaro, Jessica; Pritchard, Adrian; Prouve, Claire; Pugatch, Valery; Puig Navarro, Albert; Punzi, Giovanni; Qian, Wenbin; Quagliani, Renato; Rachwal, Bartolomiej; Rademacker, Jonas; Rama, Matteo; Ramos Pernas, Miguel; Rangel, Murilo; Raniuk, Iurii; Ratnikov, Fedor; Raven, Gerhard; Redi, Federico; Reichert, Stefanie; dos Reis, Alberto; Remon Alepuz, Clara; Renaudin, Victor; Ricciardi, Stefania; Richards, Sophie; Rihl, Mariana; Rinnert, Kurt; Rives Molina, Vicente; Robbe, Patrick; Rodrigues, Ana Barbara; Rodrigues, Eduardo; Rodriguez Lopez, Jairo Alexis; Rodriguez Perez, Pablo; Rogozhnikov, Alexey; Roiser, Stefan; Rollings, Alexandra Paige; Romanovskiy, Vladimir; Romero Vidal, Antonio; Ronayne, John William; Rotondo, Marcello; Rudolph, Matthew Scott; Ruf, Thomas; Ruiz Valls, Pablo; Saborido Silva, Juan Jose; Sadykhov, Elnur; Sagidova, Naylya; Saitta, Biagio; Salustino Guimaraes, Valdir; Sanchez Mayordomo, Carlos; Sanmartin Sedes, Brais; Santacesaria, Roberta; Santamarina Rios, Cibran; Santimaria, Marco; Santovetti, Emanuele; Sarti, Alessio; Satriano, Celestina; Satta, Alessia; Saunders, Daniel Martin; Savrina, Darya; Schael, Stefan; Schellenberg, Margarete; Schiller, Manuel; Schindler, Heinrich; Schlupp, Maximilian; Schmelling, Michael; Schmelzer, Timon; Schmidt, Burkhard; Schneider, Olivier; Schopper, Andreas; Schubert, Konstantin; Schubiger, Maxime; Schune, Marie Helene; Schwemmer, Rainer; Sciascia, Barbara; Sciubba, Adalberto; Semennikov, Alexander; Sergi, Antonino; Serra, Nicola; Serrano, Justine; Sestini, Lorenzo; Seyfert, Paul; Shapkin, Mikhail; Shapoval, Illya; Shcheglov, Yury; Shears, Tara; Shekhtman, Lev; Shevchenko, Vladimir; Siddi, Benedetto Gianluca; Silva Coutinho, Rafael; Silva de Oliveira, Luiz Gustavo; Simi, Gabriele; Simone, Saverio; Sirendi, Marek; Skidmore, Nicola; Skwarnicki, Tomasz; Smith, Eluned; Smith, Iwan Thomas; Smith, Jackson; Smith, Mark; Snoek, Hella; Sokoloff, Michael; Soler, Paul; Souza De Paula, Bruno; Spaan, Bernhard; Spradlin, Patrick; Sridharan, Srikanth; Stagni, Federico; Stahl, Marian; Stahl, Sascha; Stefko, Pavol; Stefkova, Slavorima; Steinkamp, Olaf; Stemmle, Simon; Stenyakin, Oleg; Stevenson, Scott; Stoica, Sabin; Stone, Sheldon; Storaci, Barbara; Stracka, Simone; Straticiuc, Mihai; Straumann, Ulrich; Sun, Liang; Sutcliffe, William; Swientek, Krzysztof; Syropoulos, Vasileios; Szczekowski, Marek; Szumlak, Tomasz; T'Jampens, Stephane; Tayduganov, Andrey; Tekampe, Tobias; Tellarini, Giulia; Teubert, Frederic; Thomas, Eric; van Tilburg, Jeroen; Tilley, Matthew James; Tisserand, Vincent; Tobin, Mark; Tolk, Siim; Tomassetti, Luca; Tonelli, Diego; Topp-Joergensen, Stig; Toriello, Francis; Tournefier, Edwige; Tourneur, Stephane; Trabelsi, Karim; Traill, Murdo; Tran, Minh Tâm; Tresch, Marco; Trisovic, Ana; Tsaregorodtsev, Andrei; Tsopelas, Panagiotis; Tully, Alison; Tuning, Niels; Ukleja, Artur; Ustyuzhanin, Andrey; Uwer, Ulrich; Vacca, Claudia; Vagnoni, Vincenzo; Valassi, Andrea; Valat, Sebastien; Valenti, Giovanni; Vallier, Alexis; Vazquez Gomez, Ricardo; Vazquez Regueiro, Pablo; Vecchi, Stefania; van Veghel, Maarten; Velthuis, Jaap; Veltri, Michele; Veneziano, Giovanni; Venkateswaran, Aravindhan; Vernet, Maxime; Vesterinen, Mika; Viaud, Benoit; Vieira, Daniel; Vieites Diaz, Maria; Viemann, Harald; Vilasis-Cardona, Xavier; Vitti, Marcela; Volkov, Vladimir; Vollhardt, Achim; Voneki, Balazs; Vorobyev, Alexey; Vorobyev, Vitaly; Voß, Christian; de Vries, Jacco; Vázquez Sierra, Carlos; Waldi, Roland; Wallace, Charlotte; Wallace, Ronan; Walsh, John; Wang, Jianchun; Ward, David; Wark, Heather Mckenzie; Watson, Nigel; Websdale, David; Weiden, Andreas; Whitehead, Mark; Wicht, Jean; Wilkinson, Guy; Wilkinson, Michael; Williams, Mark Richard James; Williams, Matthew; Williams, Mike; Williams, Timothy; Wilson, Fergus; Wimberley, Jack; Wishahi, Julian; Wislicki, Wojciech; Witek, Mariusz; Wormser, Guy; Wotton, Stephen; Wraight, Kenneth; Wyllie, Kenneth; Xie, Yuehong; Xing, Zhou; Xu, Zhirui; Yang, Zhenwei; Yin, Hang; Yu, Jiesheng; Yuan, Xuhao; Yushchenko, Oleg; Zarebski, Kristian Alexander; Zavertyaev, Mikhail; Zhang, Liming; Zhang, Yanxi; Zhang, Yu; Zhelezov, Alexey; Zheng, Yangheng; Zhokhov, Anatoly; Zhu, Xianglei; Zhukov, Valery; Zucchelli, Stefano

    2017-02-06

    The decays $B^+\\rightarrow J/\\psi 3\\pi^+ 2\\pi^-$ and $B^+\\rightarrow \\psi(2S) \\pi^+\\pi^+\\pi^-$ are observed for the first time using a data sample corresponding to an integrated luminosity of $3.0fb^{-1}$, collected by the LHCb experiment in proton-proton collisions at the centre-of-mass energies of 7 and 8 TeV. The branching fractions relative to that of $B^+ \\rightarrow \\psi(2S)K^+$ are measured to be \\begin{eqnarray*} \\frac {\\mathcal{B}\\left( B^+\\rightarrow J/\\psi 3\\pi^+ 2\\pi^- \\right)} {\\mathcal{B}\\left( B^+ \\rightarrow \\psi(2S)K^+ \\right)} & = & \\left( 1.88\\pm0.17\\pm0.09\\right)\\times10^{-2}, \\\\ \\frac {\\mathcal{B}\\left( B^+\\rightarrow \\psi(2S) \\pi^+\\pi^+\\pi^- \\right)} {\\mathcal{B}\\left( B^+ \\rightarrow \\psi(2S)K^+ \\right) } & = & \\left( 3.04\\pm0.50\\pm0.26\\right)\\times10^{-2}, \\end{eqnarray*} where the first uncertainties are statistical and the second are systematic.

  14. Non-cognitive behavior associated with development of Alzheimer pathology in APPswePS1dE9 mice and an effect of long-term paroxetine treatment

    DEFF Research Database (Denmark)

    Bouzinova, Elena; Olesen, Louise Ørum; Wiborg, Ove

    Alzheimer’s disease (AD) is a devastating illness characterized by a progressive loss of cognitive, social, and emotional functions, usually starting with memory impairments followed by more global cognitive deficits and neuropsychiatric symptoms. We have used APPswePS1dE9 mice model of AD...

  15. Chronic caffeine treatment reverses memory impairment and the expression of brain BNDF and TrkB in the PS1/APP double transgenic mouse model of Alzheimer’s disease

    Science.gov (United States)

    HAN, KUN; JIA, NING; LI, JI; YANG, LI; MIN, LIAN-QIU

    2013-01-01

    The objective of this study was to investigate the effects of varying doses of caffeine on memory impairment and the expression of brain neurotrophic derived factor (BNDF) and TrkB in PS1/APP double transgenic mouse models. PS1/APP double transgenic mice were administered 0.3 ml/day of saline, 1.5 mg/day of caffeine or 0.75 mg/day of caffeine for eight weeks. A water maze test and western blotting were used to determine the memory capability and expression of hippocampal BNDF and TrkB of the mice. The results demonstrated that 0.75 mg/day and 1.5 mg/day doses of caffeine significantly increased memory capability and the expression of hippocampal BDNF and TrkB in PS1/APP mice with a dose-response effect. The results suggested that chronic caffeine treatment may reverse memory impairment in PS1/APP transgenic mice, and BDNF and its receptor TrkB, may be involved in this process. PMID:23900282

  16. A New Sky Brightness Monitor

    Science.gov (United States)

    Crawford, David L.; McKenna, D.

    2006-12-01

    A good estimate of sky brightness and its variations throughout the night, the months, and even the years is an essential bit of knowledge both for good observing and especially as a tool in efforts to minimize sky brightness through local action. Hence a stable and accurate monitor can be a valuable and necessary tool. We have developed such a monitor, with the financial help of Vatican Observatory and Walker Management. The device is now undergoing its Beta test in preparation for production. It is simple, accurate, well calibrated, and automatic, sending its data directly to IDA over the internet via E-mail . Approximately 50 such monitors will be ready soon for deployment worldwide including most major observatories. Those interested in having one should enquire of IDA about details.

  17. A Longitudinal Study of Cognition, Proton MR Spectroscopy and Synaptic and Neuronal Pathology in Aging Wild-type and AβPPswe-PS1dE9 Mice

    Science.gov (United States)

    Jansen, Diane; Zerbi, Valerio; Janssen, Carola I. F.; Dederen, Pieter J. W. C.; Mutsaers, Martina P. C.; Hafkemeijer, Anne; Janssen, Anna-Lena; Nobelen, Cindy L. M.; Veltien, Andor; Asten, Jack J.; Heerschap, Arend; Kiliaan, Amanda J.

    2013-01-01

    Proton magnetic resonance spectroscopy (1H MRS) is a valuable tool in Alzheimer’s disease research, investigating the functional integrity of the brain. The present longitudinal study set out to characterize the neurochemical profile of the hippocampus, measured by single voxel 1H MRS at 7 Tesla, in the brains of AβPPSswe-PS1dE9 and wild-type mice at 8 and 12 months of age. Furthermore, we wanted to determine whether alterations in hippocampal metabolite levels coincided with behavioral changes, cognitive decline and neuropathological features, to gain a better understanding of the underlying neurodegenerative processes. Moreover, correlation analyses were performed in the 12-month-old AβPP-PS1 animals with the hippocampal amyloid-β deposition, TBS-T soluble Aβ levels and high-molecular weight Aβ aggregate levels to gain a better understanding of the possible involvement of Aβ in neurochemical and behavioral changes, cognitive decline and neuropathological features in AβPP-PS1 transgenic mice. Our results show that at 8 months of age AβPPswe-PS1dE9 mice display behavioral and cognitive changes compared to age-matched wild-type mice, as determined in the open field and the (reverse) Morris water maze. However, there were no variations in hippocampal metabolite levels at this age. AβPP-PS1 mice at 12 months of age display more severe behavioral and cognitive impairment, which coincided with alterations in hippocampal metabolite levels that suggest reduced neuronal integrity. Furthermore, correlation analyses suggest a possible role of Aβ in inflammatory processes, synaptic dysfunction and impaired neurogenesis. PMID:23717459

  18. Sky shine of proton synchrotron

    International Nuclear Information System (INIS)

    Katoh, Kazuaki; Hirayama, Hideo

    1978-01-01

    This report represents present status of the study on sky shine and the results made at KEK. At present, data at various facilities can be analyzed by the formula presented by R.H. Thomas. Measurement of sky shine at KEK has been carried out since August, 1977. The neutron level around the accelerator, spatial distribution, energy spectra and the intensities at far distant places were measured. The radiation level at the surface of shield of the accelerator is less than 0.8 mrem/h. Therefore, high sensitive detectors are required to measure the neutron at the far distant places. A 2 inch diameter BF 3 detector with polyethylene moderator and a 5.8 inch diameter BF 3 detector with same moderator were used for the measurement. Conversion from the obtained counting rate to the dose rate was made by using the conversion coefficient for fission neutrons of Cf-252. The dose rate distributions at the shielding surface of the main ring of the accelerator and the counter experiment hall were measured. At the main ring, the dose rate was less than 0.16 mrem/h, and at the counter hall the maximum dose rate was 5 mrem/h. The distance dependence of the sky shine level was measured, and the effective attenuation distance was 1300 m. The result can be expressed by the formula by Thomas. (Kato, T.)

  19. Measurement of the $B^0_s-\\overline{B}^0_s$ oscillation frequency $\\Delta m_s$ in $B^0_s \\to D^-_s (3)\\pi$ decays

    CERN Document Server

    INSPIRE-00258707; Adeva, B.; Adinolfi, M.; Adrover, C.; Affolder, A.; Ajaltouni, Z.; Albrecht, J.; Alessio, F.; Alexander, M.; Alkhazov, G.; Alvarez Cartelle, P.; Alves Jr, A.A.; Amato, S.; Amhis, Y.; Anderson, J.; Appleby, R.B.; Aquines Gutierrez, O.; Archilli, F.; Arrabito, L.; Artamonov, A.; Artuso, M.; Aslanides, E.; Auriemma, G.; Bachmann, S.; Back, J.J.; Bailey, D.S.; Balagura, V.; Baldini, W.; Barlow, R.J.; Barschel, C.; Barsuk, S.; Barter, W.; Bates, A.; Bauer, C.; Bauer, Th.; Bay, A.; Bediaga, I.; Belous, K.; Belyaev, I.; Ben-Haim, E.; Benayoun, M.; Bencivenni, G.; Benson, S.; Benton, J.; Bernet, R.; Bettler, M.O.; van Beuzekom, M.; Bien, A.; Bifani, S.; Bizzeti, A.; Bjornstad, P.M.; Blake, T.; Blanc, F.; Blanks, C.; Blouw, J.; Blusk, S.; Bobrov, A.; Bocci, V.; Bondar, A.; Bondar, N.; Bonivento, W.; Borghi, S.; Borgia, A.; Bowcock, T.J.V.; Bozzi, C.; Brambach, T.; van den Brand, J.; Bressieux, J.; Brett, D.; Brisbane, S.; Britsch, M.; Britton, T.; Brook, N.H.; Brown, H.; Buchler-Germann, A.; Burducea, I.; Bursche, A.; Buytaert, J.; Cadeddu, S.; Caicedo Carvajal, J.M.; Callot, O.; Calvi, M.; Calvo Gomez, M.; Camboni, A.; Campana, P.; Carbone, A.; Carboni, G.; Cardinale, R.; Cardini, A.; Carson, L.; Carvalho Akiba, K.; Casse, G.; Cattaneo, M.; Charles, M.; Charpentier, Ph.; Chiapolini, N.; Ciba, K.; Cid Vidal, X.; Ciezarek, G.; Clarke, P.E.L.; Clemencic, M.; Cliff, H.V.; Closier, J.; Coca, C.; Coco, V.; Cogan, J.; Collins, P.; Constantin, F.; Conti, G.; Contu, A.; Cook, A.; Coombes, M.; Corti, G.; Cowan, G.A.; Currie, R.; D'Almagne, B.; D'Ambrosio, C.; David, P.; De Bonis, I.; De Capua, S.; De Cian, M.; De Lorenzi, F.; de Miranda, J.M.; De Paula, L.; De Simone, P.; Decamp, D.; Deckenhoff, M.; Degaudenzi, H.; Deissenroth, M.; Del Buono, L.; Deplano, C.; Deschamps, O.; Dettori, F.; Dickens, J.; Dijkstra, H.; Diniz Batista, P.; Donleavy, S.; Dosil Suarez, A.; Dossett, D.; Dovbnya, A.; Dupertuis, F.; Dzhelyadin, R.; Eames, C.; Easo, S.; Egede, U.; Egorychev, V.; Eidelman, S.; van Eijk, D.; Eisele, F.; Eisenhardt, S.; Ekelhof, R.; Eklund, L.; Elsasser, Ch.; d'Enterria, D.G.; Esperante Pereira, D.; Esteve, L.; Falabella, A.; Fanchini, E.; Farber, C.; Fardell, G.; Farinelli, C.; Farry, S.; Fave, V.; Fernandez Albor, V.; Ferro-Luzzi, M.; Filippov, S.; Fitzpatrick, C.; Fontana, M.; Fontanelli, F.; Forty, R.; Frank, M.; Frei, C.; Frosini, M.; Furcas, S.; Gallas Torreira, A.; Galli, D.; Gandelman, M.; Gandini, P.; Gao, Y.; Garnier, J-C.; Garofoli, J.; Garra Tico, J.; Garrido, L.; Gaspar, C.; Gauvin, N.; Gersabeck, M.; Gershon, T.; Ghez, Ph.; Gibson, V.; Gligorov, V.V.; Gobel, C.; Golubkov, D.; Golutvin, A.; Gomes, A.; Gordon, H.; Grabalosa Gandara, M.; Graciani Diaz, R.; Granado Cardoso, L.A.; Grauges, E.; Graziani, G.; Grecu, A.; Gregson, S.; Gui, B.; Gushchin, E.; Guz, Yu.; Gys, T.; Haefeli, G.; Haen, C.; Haines, S.C.; Hampson, T.; Hansmann-Menzemer, S.; Harji, R.; Harnew, N.; Harrison, J.; Harrison, P.F.; He, J.; Heijne, V.; Hennessy, K.; Henrard, P.; Hernando Morata, J.A.; van Herwijnen, E.; Hicks, E.; Hofmann, W.; Holubyev, K.; Hopchev, P.; Hulsbergen, W.; Hunt, P.; Huse, T.; Huston, R.S.; Hutchcroft, D.; Hynds, D.; Iakovenko, V.; Ilten, P.; Imong, J.; Jacobsson, R.; Jaeger, A.; Jahjah Hussein, M.; Jans, E.; Jansen, F.; Jaton, P.; Jean-Marie, B.; Jing, F.; John, M.; Johnson, D.; Jones, C.R.; Jost, B.; Kandybei, S.; Karacson, M.; Karbach, T.M.; Keaveney, J.; Kerzel, U.; Ketel, T.; Keune, A.; Khanji, B.; Kim, Y.M.; Knecht, M.; Koblitz, S.; Koppenburg, P.; Kozlinskiy, A.; Kravchuk, L.; Kreplin, K.; Kreps, M.; Krocker, G.; Krokovny, P.; Kruse, F.; Kruzelecki, K.; Kucharczyk, M.; Kukulak, S.; Kumar, R.; Kvaratskheliya, T.; La Thi, V.N.; Lacarrere, D.; Lafferty, G.; Lai, A.; Lambert, D.; Lambert, R.W.; Lanciotti, E.; Lanfranchi, G.; Langenbruch, C.; Latham, T.; Le Gac, R.; van Leerdam, J.; Lees, J.P.; Lefevre, R.; Leflat, A.; Lefrancois, J.; Leroy, O.; Lesiak, T.; Li, L.; Li Gioi, L.; Lieng, M.; Liles, M.; Lindner, R.; Linn, C.; Liu, B.; Liu, G.; Lopes, J.H.; Lopez Asamar, E.; Lopez-March, N.; Luisier, J.; Machefert, F.; Machikhiliyan, I.V.; Maciuc, F.; Maev, O.; Magnin, J.; Malde, S.; Mamunur, R.M.D.; Manca, G.; Mancinelli, G.; Mangiafave, N.; Marconi, U.; Marki, R.; Marks, J.; Martellotti, G.; Martens, A.; Martin, L.; Martin Sanchez, A.; Martinez Santos, D.; Massafferri, A.; Mathe, Z.; Matteuzzi, C.; Matveev, M.; Maurice, E.; Maynard, B.; Mazurov, A.; McGregor, G.; McNulty, R.; Mclean, C.; Meissner, M.; Merk, M.; Merkel, J.; Messi, R.; Miglioranzi, S.; Milanes, D.A.; Minard, M.N.; Monteil, S.; Moran, D.; Morawski, P.; Mountain, R.; Mous, I.; Muheim, F.; Muller, K.; Muresan, R.; Muryn, B.; Musy, M.; Mylroie-Smith, J.; Naik, P.; Nakada, T.; Nandakumar, R.; Nardulli, J.; Nasteva, I.; Nedos, M.; Needham, M.; Neufeld, N.; Nguyen-Mau, C.; Nicol, M.; Nies, S.; Niess, V.; Nikitin, N.; Oblakowska-Mucha, A.; Obraztsov, V.; Oggero, S.; Ogilvy, S.; Okhrimenko, O.; Oldeman, R.; Orlandea, M.; Otalora Goicochea, J.M.; Owen, P.; Pal, B.; Palacios, J.; Palutan, M.; Panman, J.; Papanestis, A.; Pappagallo, M.; Parkes, C.; Parkinson, C.J.; Passaleva, G.; Patel, G.D.; Patel, M.; Paterson, S.K.; Patrick, G.N.; Patrignani, C.; Pavel-Nicorescu, C.; Pazos Alvarez, A.; Pellegrino, A.; Penso, G.; Pepe Altarelli, M.; Perazzini, S.; Perego, D.L.; Perez Trigo, E.; Perez-Calero Yzquierdo, A.; Perret, P.; Perrin-Terrin, M.; Pessina, G.; Petrella, A.; Petrolini, A.; Pie Valls, B.; Pietrzyk, B.; Pilar, T.; Pinci, D.; Plackett, R.; Playfer, S.; Plo Casasus, M.; Polok, G.; Poluektov, A.; Polycarpo, E.; Popov, D.; Popovici, B.; Potterat, C.; Powell, A.; du Pree, T.; Prisciandaro, J.; Pugatch, V.; Puig Navarro, A.; Qian, W.; Rademacker, J.H.; Rakotomiaramanana, B.; Rangel, M.S.; Raniuk, I.; Raven, G.; Redford, S.; Reid, M.M.; dos Reis, A.C.; Ricciardi, S.; Rinnert, K.; Roa Romero, D.A.; Robbe, P.; Rodrigues, E.; Rodrigues, F.; Rodriguez Perez, P.; Rogers, G.J.; Roiser, S.; Romanovsky, V.; Rouvinet, J.; Ruf, T.; Ruiz, H.; Sabatino, G.; Saborido Silva, J.J.; Sagidova, N.; Sail, P.; Saitta, B.; Salzmann, C.; Sannino, M.; Santacesaria, R.; Santinelli, R.; Santovetti, E.; Sapunov, M.; Sarti, A.; Satriano, C.; Satta, A.; Savrie, M.; Savrina, D.; Schaack, P.; Schiller, M.; Schleich, S.; Schmelling, M.; Schmidt, B.; Schneider, O.; Schopper, A.; Schune, M.H.; Schwemmer, R.; Sciubba, A.; Seco, M.; Semennikov, A.; Senderowska, K.; Sepp, I.; Serra, N.; Serrano, J.; Seyfert, P.; Shao, B.; Shapkin, M.; Shapoval, I.; Shatalov, P.; Shcheglov, Y.; Shears, T.; Shekhtman, L.; Shevchenko, O.; Shevchenko, V.; Shires, A.; Coutinho, R.Silva; Skottowe, H.P.; Skwarnicki, T.; Smith, A.C.; Smith, N.A.; Sobczak, K.; Soler, F.J.P.; Solomin, A.; Soomro, F.; Souza De Paula, B.; Spaan, B.; Sparkes, A.; Spradlin, P.; Stagni, F.; Stahl, S.; Steinkamp, O.; Stoica, S.; Stone, S.; Storaci, B.; Straticiuc, M.; Straumann, U.; Styles, N.; Subbiah, V.K.; Swientek, S.; Szczekowski, M.; Szczypka, P.; Szumlak, T.; T'Jampens, S.; Teodorescu, E.; Teubert, F.; Thomas, C.; Thomas, E.; van Tilburg, J.; Tisserand, V.; Tobin, M.; Topp-Joergensen, S.; Tran, M.T.; Tsaregorodtsev, A.; Tuning, N.; Ukleja, A.; Urquijo, P.; Uwer, U.; Vagnoni, V.; Valenti, G.; Vazquez Gomez, R.; Vazquez Regueiro, P.; Vecchi, S.; Velthuis, J.J.; Veltri, M.; Vervink, K.; Viaud, B.; Videau, I.; Vilasis-Cardona, X.; Visniakov, J.; Vollhardt, A.; Voong, D.; Vorobyev, A.; Voss, H.; Wacker, K.; Wandernoth, S.; Wang, J.; Ward, D.R.; Webber, A.D.; Websdale, D.; Whitehead, M.; Wiedner, D.; Wiggers, L.; Wilkinson, G.; Williams, M.P.; Williams, M.; Wilson, F.F.; Wishahi, J.; Witek, M.; Witzeling, W.; Wotton, S.A.; Wyllie, K.; Xie, Y.; Xing, F.; Yang, Z.; Young, R.; Yushchenko, O.; Zavertyaev, M.; Zhang, L.; Zhang, W.C.; Zhang, Y.; Zhelezov, A.; Zhong, L.; Zverev, E.; Zvyagin, A.

    2012-01-01

    The $B^0_s$-$\\overline{B}^0_s$ oscillation frequency $\\Delta m_s$ is measured with 36 pb$^{-1}$ of data collected in $pp$ collisions at $\\sqrt{s}$ = 7 TeV by the LHCb experiment at the Large Hadron Collider. A total of 1381 $B^0_s \\rightarrow D_s^- \\pi^+$ and $B^0_s \\rightarrow D_s^- \\pi^+\\pi^-\\pi^+$ signal decays are reconstructed, with average decay time resolutions of 44~fs and 36~fs, respectively. An oscillation signal with a statistical significance of 4.6\\,$\\sigma$ is observed. The measured oscillation frequency is $\\Delta m_s$ = 17.63 $\\pm$ 0.11 (stat) $\\pm$ 0.02 (syst)~ps$^{-1}$.

  20. Profiling the HER3/PI3K Pathway in Breast Tumors Using Proximity-Directed Assays Identifies Correlations between Protein Complexes and Phosphoproteins

    Science.gov (United States)

    Mukherjee, Ali; Badal, Youssouf; Nguyen, Xuan-Thao; Miller, Johanna; Chenna, Ahmed; Tahir, Hasan; Newton, Alicia; Parry, Gordon; Williams, Stephen

    2011-01-01

    Background The identification of patients for targeted antineoplastic therapies requires accurate measurement of therapeutic targets and associated signaling complexes. HER3 signaling through heterodimerization is an important growth-promoting mechanism in several tumor types and may be a principal resistance mechanism by which EGFR and HER2 expressing tumors elude targeted therapies. Current methods that can study these interactions are inadequate for formalin-fixed, paraffin-embedded (FFPE) tumor samples. Methodology and Principal Findings Herein, we describe a panel of proximity-directed assays capable of measuring protein-interactions and phosphorylation in FFPE samples in the HER3/PI3K/Akt pathway and examine the capability of these assays to inform on the functional state of the pathway. We used FFPE breast cancer cell line and tumor models for this study. In breast cancer cell lines we observe both ligand-dependent and independent activation of the pathway and strong correlations between measured activation of key analytes. When selected cell lines are treated with HER2 inhibitors, we not only observe the expected molecular effects based on mechanism of action knowledge, but also novel effects of HER2 inhibition on key targets in the HER receptor pathway. Significantly, in a xenograft model of delayed tumor fixation, HER3 phosphorylation is unstable, while alternate measures of pathway activation, such as formation of the HER3PI3K complex is preserved. Measurements in breast tumor samples showed correlations between HER3 phosphorylation and receptor interactions, obviating the need to use phosphorylation as a surrogate for HER3 activation. Significance This assay system is capable of quantitatively measuring therapeutically relevant responses and enables molecular profiling of receptor networks in both preclinical and tumor models. PMID:21297994

  1. APPswe/PS1dE9 mice with cortical amyloid pathology show a reduced NAA/Cr ratio without apparent brain atrophy: A MRS and MRI study.

    Science.gov (United States)

    Kuhla, Angela; Rühlmann, Claire; Lindner, Tobias; Polei, Stefan; Hadlich, Stefan; Krause, Bernd J; Vollmar, Brigitte; Teipel, Stefan J

    2017-01-01

    Transgenic animal models of Aβ pathology provide mechanistic insight into some aspects of Alzheimer disease (AD) pathology related to Aβ accumulation. Quantitative neuroimaging is a possible aid to improve translation of mechanistic findings in transgenic models to human end phenotypes of brain morphology or function. Therefore, we combined MRI-based morphometry, MRS-based NAA-assessment and quantitative histology of neurons and amyloid plaque load in the APPswe/PS1dE9 mouse model to determine the interrelationship between morphological changes, changes in neuron numbers and amyloid plaque load with reductions of NAA levels as marker of neuronal functional viability. The APPswe/PS1dE9 mouse showed an increase of Aβ plaques, loss of neurons and an impairment of NAA/Cr ratio, which however was not accompanied with brain atrophy. As brain atrophy is one main characteristic in human AD, conclusions from murine to human AD pathology should be drawn with caution.

  2. Night sky a falcon field guide

    CERN Document Server

    Nigro, Nicholas

    2012-01-01

    Night Sky: A Falcon Field Guide covers both summer and winter constellations, planets, and stars found in the northern hemisphere. Conveniently sized to fit in a pocket and featuring detailed photographs, this informative guide makes it easy to identify objects in the night sky even from one's own backyard. From information on optimal weather conditions, preferred viewing locations, and how to use key tools of the trade, this handbook will help you adeptly navigate to and fro the vast and dynamic nighttime skies, and you'll fast recognize that the night sky's the limit.

  3. Daytime Water Detection Based on Sky Reflections

    Science.gov (United States)

    Rankin, Arturo; Matthies, Larry; Bellutta, Paolo

    2011-01-01

    A water body s surface can be modeled as a horizontal mirror. Water detection based on sky reflections and color variation are complementary. A reflection coefficient model suggests sky reflections dominate the color of water at ranges > 12 meters. Water detection based on sky reflections: (1) geometrically locates the pixel in the sky that is reflecting on a candidate water pixel on the ground (2) predicts if the ground pixel is water based on color similarity and local terrain features. Water detection has been integrated on XUVs.

  4. Noggin and BMP4 co-modulate adult hippocampal neurogenesis in the APP{sub swe}/PS1{sub {Delta}E9} transgenic mouse model of Alzheimer's disease

    Energy Technology Data Exchange (ETDEWEB)

    Tang, Jun [Department of Medical Genetics, Third Military Medical University, Chongqing 400038 (China); Department of Physiology, Third Military Medical University, Chongqing 400038 (China); Song, Min; Wang, Yanyan [Department of Medical Genetics, Third Military Medical University, Chongqing 400038 (China); Fan, Xiaotang [Department of Histology and Embryology, Third Military Medical University, Chongqing 400038 (China); Xu, Haiwei, E-mail: haiweixu2001@yahoo.com.cn [Department of Physiology, Third Military Medical University, Chongqing 400038 (China); Bai, Yun, E-mail: baiyungene@gmail.com [Department of Medical Genetics, Third Military Medical University, Chongqing 400038 (China)

    2009-07-31

    In addition to the subventricular zone, the dentate gyrus of the hippocampus is one of the few brain regions in which neurogenesis continues into adulthood. Perturbation of neurogenesis can alter hippocampal function, and previous studies have shown that neurogenesis is dysregulated in Alzheimer disease (AD) brain. Bone morphogenetic protein-4 (BMP4) and its antagonist Noggin have been shown to play important roles both in embryonic development and in the adult nervous system, and may regulate hippocampal neurogenesis. Previous data indicated that increased expression of BMP4 mRNA within the dentate gyrus might contribute to decreased hippocampal cell proliferation in the APP{sub swe}/PS1{sub {Delta}E9} mouse AD model. However, it is not known whether the BMP antagonist Noggin contributes to the regulation of neurogenesis. We therefore studied the relative expression levels and localization of BMP4 and its antagonist Noggin in the dentate gyrus and whether these correlated with changes in neurogenesis in 6-12 mo old APP{sub swe}/PS1{sub {Delta}E9} transgenic mice. Bromodeoxyuridine (BrdU) was used to label proliferative cells. We report that decreased neurogenesis in the APP/PS1 transgenic mice was accompanied by increased expression of BMP4 and decreased expression of Noggin at both the mRNA and protein levels; statistical analysis showed that the number of proliferative cells at different ages correlated positively with Noggin expression and negatively with BMP4 expression. Intraventricular administration of a chimeric Noggin/Fc protein was used to block the action of endogenous BMP4; this resulted in a significant increase in the number of BrdU-labeled cells in dentate gyrus subgranular zone and hilus in APP/PS1 mice. These results suggest that BMP4 and Noggin co-modulate neurogenesis.

  5. MER5101, a novel Aβ1-15:DT conjugate vaccine, generates a robust anti-Aβ antibody response and attenuates Aβ pathology and cognitive deficits in APPswe/PS1ΔE9 transgenic mice.

    Science.gov (United States)

    Liu, Bin; Frost, Jeffrey L; Sun, Jing; Fu, Hongjun; Grimes, Stephen; Blackburn, Peter; Lemere, Cynthia A

    2013-04-17

    Active amyloid-β (Aβ) immunotherapy is under investigation to prevent or treat early Alzheimer's disease (AD). In 2002, a Phase II clinical trial (AN1792) was halted due to meningoencephalitis in ∼6% of the AD patients, possibly caused by a T-cell-mediated immunological response. Thus, generating a vaccine that safely generates high anti-Aβ antibody levels in the elderly is required. In this study, MER5101, a novel conjugate of Aβ1-15 peptide (a B-cell epitope fragment) conjugated to an immunogenic carrier protein, diphtheria toxoid (DT), and formulated in a nanoparticular emulsion-based adjuvant, was administered to 10-month-old APPswe/PS1ΔE9 transgenic (Tg) and wild-type (Wt) mice. High anti-Aβ antibody levels were observed in both vaccinated APPswe/PS1ΔE9 Tg and Wt mice. Antibody isotypes were mainly IgG1 and IgG2b, suggesting a Th2-biased response. Restimulation of splenocytes with the Aβ1-15:DT conjugate resulted in a strong proliferative response, whereas proliferation was absent after restimulation with Aβ1-15 or Aβ1-40/42 peptides, indicating a cellular immune response against DT while avoiding an Aβ-specific T-cell response. Moreover, significant reductions in cerebral Aβ plaque burden, accompanied by attenuated microglial activation and increased synaptic density, were observed in MER5101-vaccinated APPswe/PS1ΔE9 Tg mice compared with Tg adjuvant controls. Last, MER5101-immunized APPswe/PS1ΔE9 Tg mice showed improvement of cognitive deficits in both contextual fear conditioning and the Morris water maze. Our novel, highly immunogenic Aβ conjugate vaccine, MER5101, shows promise for improving Aβ vaccine safety and efficacy and therefore, may be useful for preventing and/or treating early AD.

  6. Reduced basal and novelty-induced levels of activity-regulated cytoskeleton associated protein (Arc) and c-Fos mRNA in the cerebral cortex and hippocampus of APPswe/PS1ΔE9 transgenic mice

    DEFF Research Database (Denmark)

    Christensen, Ditte Z; Thomsen, Morten Skøtt; Mikkelsen, Jens D

    2013-01-01

    to a novel open field environment was compromised in different neocortical areas and the hippocampal formation in APP/PS1ΔE9 transgenic mice characterized by pronounced accumulation and deposition of beta amyloid (Aβ). Notably, the basal level of Arc and c-fos mRNA in the neocortex was significantly lower...... in APP/PS1ΔE9 compared to wild-type mice. Novelty exposure induced an increase in Arc and c-Fos mRNA in the medial prefrontal cortex (mPFC), parietal cortex, and hippocampal formation in both APP/PS1ΔE9 transgenic and wild-type mice. However, novelty-induced IEG expression did not reach the same levels...... in a transgenic mouse model of Alzheimer's disease, which is most pronounced in cortical regions, indicating that a decreased functional response in IEG expression could be partly responsible for the cognitive deficits observed in patients with Alzheimer's disease....

  7. L-3-n-Butylphthalide Regulates Proliferation, Migration, and Differentiation of Neural Stem Cell In Vitro and Promotes Neurogenesis in APP/PS1 Mouse Model by Regulating BDNF/TrkB/CREB/Akt Pathway.

    Science.gov (United States)

    Lei, Hui; Zhang, Yu; Huang, Longjian; Xu, Shaofeng; Li, Jiang; Yang, Lichao; Wang, Ling; Xing, Changhong; Wang, Xiaoliang; Peng, Ying

    2018-05-04

    Alzheimer's disease (AD) is characterized by extracellular accumulation of β-amyloid peptides (Aβ) and intracellular neurofibrillary tangles, along with cognitive decline and neurodegeneration. The cognitive deficit is considered to be due to the dysfunction of hippocampal neurogenesis. Although L-3-n-butylphthalide (L-NBP) has been shown beneficial effects in multiple AD animal models, the underlying molecular mechanisms are still elusive. In this study, we investigated the effects of L-NBP on neurogenesis both in vitro and in vivo. L-NBP promoted proliferation and migration of neural stem cells and induced neuronal differentiation in vitro. In APP/PS1 mice, L-NBP induced neurogenesis in the dentate gyrus and improved cognitive functions. In addition, L-NBP significantly increased the expressions of BDNF and NGF, tyrosine phosphorylation of its cognate receptor, and phosphorylation of Akt as well as CREB at Ser133 in the hippocampus of APP/PS1 mice. These results indicated that L-NBP might stimulate the proliferation, migration, and differentiation of hippocampal neural stem cells and reversed cognitive deficits in APP/PS1 mice. BDNF/TrkB/CREB/Akt signaling pathway might be involved.

  8. Sky alert! when satellites fail

    CERN Document Server

    Johnson, Les

    2013-01-01

    How much do we depend on space satellites? Defense, travel, agriculture, weather forecasting, mobile phones and broadband, commerce...the list seems endless. But what would our live be like if the unimaginable happened and, by accident or design, those space assets disappeared? Sky Alert! explores what our world would be like, looking in turn at areas where the loss could have catastrophic effects. The book - demonstrates our dependence on space technology and satellites; - outlines the effect on our economy, defense, and daily lives if satellites and orbiting spacecraft were destroyed; - illustrates the danger of dead satellites, spent rocket stages, and space debris colliding with a functioning satellites; - demonstrates the threat of dramatically increased radiation levels associated with geomagnetic storms; - introduces space as a potential area of conflict between nations.

  9. Protecting Dark Skies in Chile

    Science.gov (United States)

    Smith, R. Chris; Sanhueza, Pedro; Phillips, Mark

    2018-01-01

    Current projections indicate that Chile will host approximately 70% of the astronomical collecting area on Earth by 2030, augmenting the enormous area of ALMA with that of three next-generation optical telescopes: LSST, GMTO, and E-ELT. These cutting-edge facilities represent billions of dollars of investment in the astronomical facilities hosted in Chile. The Chilean government, Chilean astronomical community, and the international observatories in Chile have recognized that these investments are threatened by light pollution, and have formed a strong collaboration to work at managing the threats. We will provide an update on the work being done in Chile, ranging from training municipalities about new lighting regulations to exploring international recognition of the dark sky sites of Northern Chile.

  10. The ShcA SH2 domain engages a 14-3-3/PI3'K signaling complex and promotes breast cancer cell survival.

    Science.gov (United States)

    Ursini-Siegel, J; Hardy, W R; Zheng, Y; Ling, C; Zuo, D; Zhang, C; Podmore, L; Pawson, T; Muller, W J

    2012-11-29

    The ShcA adapter protein transmits activating signals downstream of receptor and cytoplasmic tyrosine kinases through the establishment of phosphotyrosine-dependent complexes. In this regard, ShcA possesses both a phosphotyrosine-binding domain (PTB) and Src homology 2 domain (SH2), which bind phosphotyrosine residues in a sequence-specific manner. Although the majority of receptor tyrosine kinases expressed in breast cancer cells bind the PTB domain, very little is known regarding the biological importance of SH2-driven ShcA signaling during mammary tumorigenesis. To address this, we employed transgenic mice expressing a mutant ShcA allele harboring a non-functional SH2 domain (ShcR397K) under the transcriptional control of the endogenous ShcA promoter. Using transplantation approaches, we demonstrate that SH2-dependent ShcA signaling within the mammary epithelial compartment is essential for breast tumor outgrowth, survival and the development of lung metastases. We further show that the ShcA SH2 domain activates the AKT pathway, potentially through a novel SH2-mediated complex between ShcA, 14-3-3ζ and the p85 regulatory subunit of phosphatidylinositol 3 (PI3') kinase. This study is the first to demonstrate that the SH2 domain of ShcA is critical for tumor survival during mammary tumorigenesis.

  11. BIG SKY CARBON SEQUESTRATION PARTNERSHIP

    Energy Technology Data Exchange (ETDEWEB)

    Susan M. Capalbo

    2005-01-31

    The Big Sky Carbon Sequestration Partnership, led by Montana State University, is comprised of research institutions, public entities and private sectors organizations, and the Confederated Salish and Kootenai Tribes and the Nez Perce Tribe. Efforts under this Partnership in Phase I fall into four areas: evaluation of sources and carbon sequestration sinks that will be used to determine the location of pilot demonstrations in Phase II; development of GIS-based reporting framework that links with national networks; designing an integrated suite of monitoring, measuring, and verification technologies and assessment frameworks; and initiating a comprehensive education and outreach program. The groundwork is in place to provide an assessment of storage capabilities for CO{sub 2} utilizing the resources found in the Partnership region (both geological and terrestrial sinks), that would complement the ongoing DOE research. Efforts are underway to showcase the architecture of the GIS framework and initial results for sources and sinks. The region has a diverse array of geological formations that could provide storage options for carbon in one or more of its three states. Likewise, initial estimates of terrestrial sinks indicate a vast potential for increasing and maintaining soil C on forested, agricultural, and reclaimed lands. Both options include the potential for offsetting economic benefits to industry and society. Steps have been taken to assure that the GIS-based framework is consistent among types of sinks within the Big Sky Partnership area and with the efforts of other western DOE partnerships. The Partnership recognizes the critical importance of measurement, monitoring, and verification technologies to support not only carbon trading but all policies and programs that DOE and other agencies may want to pursue in support of GHG mitigation. The efforts in developing and implementing MMV technologies for geological sequestration reflect this concern. Research is

  12. Sky Subtraction with Fiber-Fed Spectrograph

    Science.gov (United States)

    Rodrigues, Myriam

    2017-09-01

    "Historically, fiber-fed spectrographs had been deemed inadequate for the observation of faint targets, mainly because of the difficulty to achieve high accuracy on the sky subtraction. The impossibility to sample the sky in the immediate vicinity of the target in fiber instruments has led to a commonly held view that a multi-object fibre spectrograph cannot achieve an accurate sky subtraction under 1% contrary to their slit counterpart. The next generation of multi-objects spectrograph at the VLT (MOONS) and the planed MOS for the E-ELT (MOSAIC) are fiber-fed instruments, and are aimed to observed targets fainter than the sky continuum level. In this talk, I will present the state-of-art on sky subtraction strategies and data reduction algorithm specifically developed for fiber-fed spectrographs. I will also present the main results of an observational campaign to better characterise the sky spatial and temporal variations ( in particular the continuum and faint sky lines)."

  13. NASA Science Engagement Through "Sky Art"

    Science.gov (United States)

    Bethea, K. L.; Damadeo, K.

    2013-12-01

    Sky Art is a NASA-funded online community where the public can share in the beauty of nature and the science behind it. At the center of Sky Art is a gallery of amateur sky photos submitted by users that are related to NASA Earth science mission research areas. Through their submissions, amateur photographers from around the world are engaged in the process of making observations, or taking pictures, of the sky just like many NASA science instruments. By submitting their pictures and engaging in the online community discussions and interactions with NASA scientists, users make the connection between the beauty of nature and atmospheric science. Sky Art is a gateway for interaction and information aimed at drawing excitement and interest in atmospheric phenomena including sunrises, sunsets, moonrises, moonsets, and aerosols, each of which correlates to a NASA science mission. Educating the public on atmospheric science topics in an informal way is a central goal of Sky Art. NASA science is included in the community through interaction from scientists, NASA images, and blog posts on science concepts derived from the images. Additionally, the website connects educators through the formal education pathway where science concepts are taught through activities and lessons that align with national learning standards. Sky Art was conceived as part of the Education and Public Outreach program of the SAGE III on ISS mission. There are currently three other NASA mission involved with Sky Art: CALIPSO, GPM, and CLARREO. This paper will discuss the process of developing the Sky Art online website, the challenges of growing a community of users, as well as the use of social media and mobile applications in science outreach and education.

  14. Big Sky Carbon Sequestration Partnership

    Energy Technology Data Exchange (ETDEWEB)

    Susan Capalbo

    2005-12-31

    The Big Sky Carbon Sequestration Partnership, led by Montana State University, is comprised of research institutions, public entities and private sectors organizations, and the Confederated Salish and Kootenai Tribes and the Nez Perce Tribe. Efforts under this Partnership in Phase I are organized into four areas: (1) Evaluation of sources and carbon sequestration sinks that will be used to determine the location of pilot demonstrations in Phase II; (2) Development of GIS-based reporting framework that links with national networks; (3) Design of an integrated suite of monitoring, measuring, and verification technologies, market-based opportunities for carbon management, and an economic/risk assessment framework; (referred to below as the Advanced Concepts component of the Phase I efforts) and (4) Initiation of a comprehensive education and outreach program. As a result of the Phase I activities, the groundwork is in place to provide an assessment of storage capabilities for CO{sub 2} utilizing the resources found in the Partnership region (both geological and terrestrial sinks), that complements the ongoing DOE research agenda in Carbon Sequestration. The geology of the Big Sky Carbon Sequestration Partnership Region is favorable for the potential sequestration of enormous volume of CO{sub 2}. The United States Geological Survey (USGS 1995) identified 10 geologic provinces and 111 plays in the region. These provinces and plays include both sedimentary rock types characteristic of oil, gas, and coal productions as well as large areas of mafic volcanic rocks. Of the 10 provinces and 111 plays, 1 province and 4 plays are located within Idaho. The remaining 9 provinces and 107 plays are dominated by sedimentary rocks and located in the states of Montana and Wyoming. The potential sequestration capacity of the 9 sedimentary provinces within the region ranges from 25,000 to almost 900,000 million metric tons of CO{sub 2}. Overall every sedimentary formation investigated

  15. BIG SKY CARBON SEQUESTRATION PARTNERSHIP

    Energy Technology Data Exchange (ETDEWEB)

    Susan M. Capalbo

    2004-06-01

    The Big Sky Partnership, led by Montana State University, is comprised of research institutions, public entities and private sectors organizations, and the Confederated Salish and Kootenai Tribes and the Nez Perce Tribe. Efforts during the second performance period fall into four areas: evaluation of sources and carbon sequestration sinks; development of GIS-based reporting framework; designing an integrated suite of monitoring, measuring, and verification technologies; and initiating a comprehensive education and outreach program. At the first two Partnership meetings the groundwork was put in place to provide an assessment of capture and storage capabilities for CO{sub 2} utilizing the resources found in the Partnership region (both geological and terrestrial sinks), that would complement the ongoing DOE research. The region has a diverse array of geological formations that could provide storage options for carbon in one or more of its three states. Likewise, initial estimates of terrestrial sinks indicate a vast potential for increasing and maintaining soil C on forested, agricultural, and reclaimed lands. Both options include the potential for offsetting economic benefits to industry and society. Steps have been taken to assure that the GIS-based framework is consistent among types of sinks within the Big Sky Partnership area and with the efforts of other western DOE partnerships. Efforts are also being made to find funding to include Wyoming in the coverage areas for both geological and terrestrial sinks and sources. The Partnership recognizes the critical importance of measurement, monitoring, and verification technologies to support not only carbon trading but all policies and programs that DOE and other agencies may want to pursue in support of GHG mitigation. The efforts begun in developing and implementing MMV technologies for geological sequestration reflect this concern. Research is also underway to identify and validate best management practices for

  16. β-asarone improves learning and memory and reduces Acetyl Cholinesterase and Beta-amyloid 42 levels in APP/PS1 transgenic mice by regulating Beclin-1-dependent autophagy.

    Science.gov (United States)

    Deng, Minzhen; Huang, Liping; Ning, Baile; Wang, Nanbu; Zhang, Qinxin; Zhu, Caixia; Fang, Yongqi

    2016-12-01

    Alzheimer's disease (AD) is the most common neurodegenerative disorder in the elderly, and studies have suggested that β-asarone has pharmacological effects on beta-amyloid (Aβ) injected in the rat hippocampus. However, the effect of β-asarone on autophagy in the APP/PS1 transgenic mouse is unreported. APP/PS1 transgenic mice were randomly divided into six groups (n=10/group): an untreated group, an Aricept-treated group, a 3-MA-treated group, a rapamycin-treated group, an LY294002-treated group, a β-asarone-treated group. The control group consisted of wild-type C57BL/6 mice. All treatments were administered to the mice for 30 days. Spatial learning and memory were assessed by water maze, passive avoidance, and step-down tests. AChE and Aβ 42 levels in the hippocampus were determined by ELISA. p-Akt, p-mTOR, and LC3B expression were detected by flow cytometry. The expression of p-Akt, p-mTOR, Beclin-1, and p62 proteins was assessed by western blot. Changes in autophagy were viewed using a transmission electron microscope. APP and Beclin-1 mRNA levels were measured by Real-Time PCR. The learning and memory of APP/PS1 transgenic mice were improved significantly after β-asarone treatment compared with the untreated group. In addition, β-asarone treatment reduced AChE and Aβ 42 levels, increased p-mTOR and p62 expression, decreased p-Akt, Beclin-1, and LC3B expression, decreased the number of autophagosomes and reduced APP mRNA and Beclin-1 mRNA levels compared with the untreated group. That is, β-asarone treatment can improve the learning and memory abilities of APP/PS1 transgenic mouse by inhibiting Beclin-1-dependent autophagy via the PI3K/Akt/mTOR pathway. Copyright © 2016 Elsevier B.V. All rights reserved.

  17. Students in Advanced Research for Sky Surveillance

    National Research Council Canada - National Science Library

    Gehrels, Tom

    1997-01-01

    .... to 2000 sqare degrees of sky are searched each year to a V magnitude level of 21.3. Spacewatch discoveries support studies of the evolution of the Centaur, Trojan, Main-Belt, and Earth-approaching asteroid populations...

  18. STARS4ALL Night Sky Brightness Photometer

    Directory of Open Access Journals (Sweden)

    Jaime Zamorano

    2017-06-01

    Full Text Available We present the main features of TESS-W, the first version of a series of inexpensive but reliable photometers that will be used to measure night sky brightness. The bandpass is extended to the red with respect of that of the Sky Quality Meter (SQM. TESS-W connects to a router via WIFI and it sends automatically the brightness values to a data repository using Internet of Things protocols. The device includes an infrared sensor to estimate the cloud coverage. It is designed for fixed stations to monitor the evolution of the sky brightness. The photometer could also be used in local mode connected to a computer or tablet to gather data from a moving vehicle. The photometer is being developed within STARS4ALL project, a collective awareness platform for promoting dark skies in Europe, funded by the EU. We intend to extend the existing professional networks to a citizen-based network of photometers. 

  19. Clear sky solar insolation data for Islamabad

    International Nuclear Information System (INIS)

    Akhter, P.; Baig, A.; Mufti, A.

    1990-09-01

    Monthly average values of both integrated and instantaneous clear sky solar radiation components for Islamabad territory have been presented and discussed. The components include total, direct normal, direct horizontal, global and diffuse radiations, sun hours, number of clear days and temperature for solar energy applications. Beam irradiance values are used to get clear sky (maximum) sun hours by ab-initio. The need for replacing the conventional sunshine recorder is discussed. (author). 8 refs, 1 fig, 2 tabs

  20. Characterizing Sky Spectra Using SDSS BOSS Data

    Science.gov (United States)

    Florez, Lina Maria; Strauss, Michael A.

    2018-01-01

    In the optical/near-infrared spectra gathered by a ground-based telescope observing very faint sources, the strengths of the emission lines due to the Earth’s atmosphere can be many times larger than the fluxes of the sources we are interested in. Thus the limiting factor in faint-object spectroscopy is the degree to which systematics in the sky subtraction can be minimized. Longwards of 6000 Angstroms, the night-sky spectrum is dominated by multiple vibrational/rotational transitions of the OH radical from our upper atmosphere. While the wavelengths of these lines are the same in each sky spectrum, their relative strengths vary considerably as a function of time and position on the sky. The better we can model their strengths, the better we can hope to subtract them off. We expect that the strength of lines from common upper energy levels will be correlated with one another. We used flux-calibrated sky spectra from the Sloan Digital Sky Survey Baryon Oscillation Spectroscopic Survey (SDSS BOSS) to explore these correlations. Our aim is to use these correlations for creating improved sky subtraction algorithms for the Prime Focus Spectrograph (PFS) on the 8.2-meter Subaru Telescope. When PFS starts gathering data in 2019, it will be the most powerful multi-object spectrograph in the world. Since PFS will be gathering data on sources as faint as 24th magnitude and fainter, it's of upmost importance to be able to accurately measure and subtract sky spectra from the data that we receive.

  1. The Mythology of the Night Sky

    Science.gov (United States)

    Falkner, David E.

    The word "planet" comes from the Latin word planeta and the Greek word planes, which means "wanderer." When the ancient Greeks studied the night sky they noticed that most of the stars remained in the same position relative to all the other stars, but a few stars seem to move in the sky from day to day, week to week, and month to month. The Greeks called these rogue stars "wanderers" because they wandered through the starry background.

  2. Big Sky Carbon Sequestration Partnership

    Energy Technology Data Exchange (ETDEWEB)

    Susan M. Capalbo

    2005-11-01

    The Big Sky Carbon Sequestration Partnership, led by Montana State University, is comprised of research institutions, public entities and private sectors organizations, and the Confederated Salish and Kootenai Tribes and the Nez Perce Tribe. Efforts under this Partnership in Phase I fall into four areas: evaluation of sources and carbon sequestration sinks that will be used to determine the location of pilot demonstrations in Phase II; development of GIS-based reporting framework that links with national networks; designing an integrated suite of monitoring, measuring, and verification technologies and assessment frameworks; and initiating a comprehensive education and outreach program. The groundwork is in place to provide an assessment of storage capabilities for CO2 utilizing the resources found in the Partnership region (both geological and terrestrial sinks), that would complement the ongoing DOE research agenda in Carbon Sequestration. The region has a diverse array of geological formations that could provide storage options for carbon in one or more of its three states. Likewise, initial estimates of terrestrial sinks indicate a vast potential for increasing and maintaining soil C on forested, agricultural, and reclaimed lands. Both options include the potential for offsetting economic benefits to industry and society. Steps have been taken to assure that the GIS-based framework is consistent among types of sinks within the Big Sky Partnership area and with the efforts of other DOE regional partnerships. The Partnership recognizes the critical importance of measurement, monitoring, and verification technologies to support not only carbon trading but all policies and programs that DOE and other agencies may want to pursue in support of GHG mitigation. The efforts in developing and implementing MMV technologies for geological sequestration reflect this concern. Research is also underway to identify and validate best management practices for soil C in the

  3. Solar Resource Assessment with Sky Imagery and a Virtual Testbed for Sky Imager Solar Forecasting

    Science.gov (United States)

    Kurtz, Benjamin Bernard

    In recent years, ground-based sky imagers have emerged as a promising tool for forecasting solar energy on short time scales (0 to 30 minutes ahead). Following the development of sky imager hardware and algorithms at UC San Diego, we present three new or improved algorithms for sky imager forecasting and forecast evaluation. First, we present an algorithm for measuring irradiance with a sky imager. Sky imager forecasts are often used in conjunction with other instruments for measuring irradiance, so this has the potential to decrease instrumentation costs and logistical complexity. In particular, the forecast algorithm itself often relies on knowledge of the current irradiance which can now be provided directly from the sky images. Irradiance measurements are accurate to within about 10%. Second, we demonstrate a virtual sky imager testbed that can be used for validating and enhancing the forecast algorithm. The testbed uses high-quality (but slow) simulations to produce virtual clouds and sky images. Because virtual cloud locations are known, much more advanced validation procedures are possible with the virtual testbed than with measured data. In this way, we are able to determine that camera geometry and non-uniform evolution of the cloud field are the two largest sources of forecast error. Finally, with the assistance of the virtual sky imager testbed, we develop improvements to the cloud advection model used for forecasting. The new advection schemes are 10-20% better at short time horizons.

  4. Experience in Solar System and Sky Motions

    Science.gov (United States)

    Coles, K. S.

    2017-12-01

    To help students predict where they will see objects in the sky, they must comprehend sky motion and the relative motions of individual objects. Activities to promote this comprehension among college and secondary students include: Tracking star motion in the planetarium: Students predict star motion by marking the expected path on plastic hemisphere models of the celestial dome. They check their prediction by observing and marking the actual motion. For comprehension, comparing motion in different parts of the sky surpasses two-dimensional views of the sky in books or on computers. Mastery is assessed by the same exercise with the sky set at other latitudes, including those on the other side of the equator. Making sundials: Students first make a horizontal sundial for the latitude of their choice following written directions (e.g., Waugh, 1973). One problem to solve is how to convert sundial time to standard time. A prompt is a picture of the analemma (the position of the Sun in the sky at a fixed clock time over the course of a year). Tests of mastery include the questions, "What accounts for the shape of the analemma?" and "What information is needed to predict the shape of the analemma one would see on other planets?" Reference: Waugh, A. E., 1973, Sundials: their theory and construction: Dover, 228 p.

  5. S1P/S1PR3 signaling mediated proliferation of pericytes via Ras/pERK pathway and CAY10444 had beneficial effects on spinal cord injury.

    Science.gov (United States)

    Tang, Hai-Bin; Jiang, Xiao-Jian; Wang, Chen; Liu, Shi-Chang

    2018-04-15

    Pericytes have long been regarded merely to maintain structural and functional integrity of blood-brain barrier (BBB). Nevertheless, it has also been identified as a component of scar-forming stromal cells after spinal cord injury (SCI). In process of enlargement of spinal cavity after SCI, the number of pericytes increased and outnumbered astrocytes. However, the mechanism of proliferation of pericytes remains unclear. Sphingosine-1-phosphate (S1P) has been reported to play important roles in the formation of glia scar, but previous studies had paid more attention to the astrocytes. The present study aimed to observe the effects of S1P and S1P receptors (S1PRs) on proliferation of pericytes and investigate the underlying mechanism. By double immunostaining, we found that the number of PDGFRβ-positive pericytes was gradually increased and sealed the cavity, which surrounded by reactive astrocytes. Moreover, the subtype of S1PR3 was found to be induced by SCI and mainly expressed on pericytes. Further, by use of CAY10444, an inhibitor of S1PR3, we showed that S1P/S1PR3 mediated the proliferation of pericytes through Ras/pERK pathway. Moreover, CAY10444 was found to have the effects of enhancing neuronal survival, alleviating glial scar formation, and improving locomotion recovery after SCI. The results suggested that S1P/S1PR3 might be a promising target for clinical therapy for SCI. Copyright © 2018 Elsevier Inc. All rights reserved.

  6. Active immunization with the peptide epitope vaccine Aβ3-10-KLH induces a Th2-polarized anti-Aβ antibody response and decreases amyloid plaques in APP/PS1 transgenic mice.

    Science.gov (United States)

    Ding, Li; Meng, Yuan; Zhang, Hui-Yi; Yin, Wen-Chao; Yan, Yi; Cao, Yun-Peng

    2016-11-10

    Active amyloid-β (Aβ) immunotherapy is effective in preventing Aβ deposition, facilitating plaque clearance, and improving cognitive functions in mouse models of Alzheimer's disease (AD). Developing a safe and effective AD vaccine requires a delicate balance between inducing adequate humoral immune responses and avoiding T cell-mediated autoimmune responses. In this study, we designed 2 peptide epitope vaccines, Aβ3-10-KLH and 5Aβ3-10, prepared respectively by coupling Aβ3-10 to the immunogenic carrier protein keyhole limpet hemocyanin (KLH) or by joining 5 Aβ3-10 epitopes linearly in tandem. Young APP/PS1 mice were immunized subcutaneously with Aβ3-10-KLH or 5Aβ3-10 mixed with Freund's adjuvant, and the immunopotencies of these Aβ3-10 peptide vaccines were tested. Aβ3-10-KLH elicited a robust Th2-polarized anti-Aβ antibody response and inhibited Aβ deposition in APP/PS1 mice. However, 5Aβ3-10 did not induce an effective humoral immune response. These results indicated that Aβ3-10-KLH may be a safe and efficient vaccine for AD and that conjugating the antigen to a carrier protein may be more effective than linking multiple peptide antigens in tandem in applications for antibody production and vaccine preparation. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  7. Educating for the Preservation of Dark Skies

    Science.gov (United States)

    Preston, Sandra Lee; Cianciolo, Frank; Wetzel, Marc; Finkelstein, Keely; Wren, William; Nance, Craig

    2015-08-01

    The stars at night really are big and bright deep in the heart of Texas at the McDonald Observatory near Fort Davis, Texas. Each year 80,000 visitors from all over the world make the pilgrimage to the Observatory to attend one of the three-times-a-week star parties. Many experience, for the first time, the humbling, splendor of a truly dark night sky. Over the last several years, the Observatory has experienced dramatic increases in visitation demonstrating the public’s appetite for science education, in general, and interest in the night sky, in particular. This increasing interest in astronomy is, ironically, occurring at a time when most of humanity’s skies are becoming increasingly light-polluted frustrating this natural interest. Dark skies and knowledgeable education and outreach staff are an important resource in maintaining the public’s interest in astronomy, support for astronomical research, and local tourism.This year Observatory educators were inspired by the observance of the International Year of Light to promote healthy outdoor lighting through its popular Astronomy Day distance learning program. This program reaches tens of thousands of K-12 students in Texas and other states with a message of how they can take action to preserve dark skies. As well, more than a thousand Boy Scouts visiting during the summer months receive a special program, which includes activities focusing on good lighting practices, thereby earning them credits toward an astronomy badge.The Observatory also offers a half-a-dozen K-12 teacher professional development workshops onsite each year, which provide about 90 teachers with dark skies information, best-practice lighting demonstrations, and red flashlights. Multi-year workshops for National Park and State of Texas Parks personnel are offered on dark sky preservation and sky interpretation at McDonald and a Dark Skies fund for retrofitting lights in the surrounding area has been established. The Observatory also uses

  8. Sky camera imagery processing based on a sky classification using radiometric data

    International Nuclear Information System (INIS)

    Alonso, J.; Batlles, F.J.; López, G.; Ternero, A.

    2014-01-01

    As part of the development and expansion of CSP (concentrated solar power) technology, one of the most important operational requirements is to have complete control of all factors which may affect the quantity and quality of the solar power produced. New developments and tools in this field are focused on weather forecasting improving both operational security and electricity production. Such is the case with sky cameras, devices which are currently in use in some CSP plants and whose use is expanding in the new technology sector. Their application is mainly focused on cloud detection, estimating their movement as well as their influence on solar radiation attenuation indeed, the presence of clouds is the greatest factor involved in solar radiation attenuation. The aim of this work is the detection and analysis of clouds from images taken by a TSI-880 model sky. In order to obtain accurate image processing, three different models were created, based on a previous sky classification using radiometric data and representative sky conditions parameters. As a consequence, the sky can be classified as cloudless, partially-cloudy or overcast, delivering an average success rate of 92% in sky classification and cloud detection. - Highlights: • We developed a methodology for detection of clouds in total sky imagery (TSI-880). • A classification of sky is presented according to radiometric data and sky parameters. • The sky can be classified as cloudless, partially cloudy and overcast. • The images processing is based on the sky classification for the detection of clouds. • The average success of the developed model is around 92%

  9. The Accuracy of RADIANCE Software in Modelling Overcast Sky Condition

    OpenAIRE

    Baharuddin

    2013-01-01

    A validation study of the sky models of RADIANCE simulation software against the overcast sky condition has been carried out in order to test the accuracy of sky model of RADIANCE for modeling the overcast sky condition in Hong Kong. Two sets of data have been analysed. Firstly, data collected from a set of experiments using a physical scale model. In this experiment, the illuminance of four points inside the model was measured under real sky conditions. Secondly, the RADIANCE simulation has ...

  10. Dark Skies: Local Success, Global Challenge

    Science.gov (United States)

    Lockwood, G. W.

    2009-01-01

    The Flagstaff, Arizona 1987 lighting code reduced the growth rate of man-made sky glow by a third. Components of the code include requirements for full cutoff lighting, lumens per acre limits in radial zones around observatories, and use of low-pressure sodium monochromatic lighting for roadways and parking lots. Broad public acceptance of Flagstaff's lighting code demonstrates that dark sky preservation has significant appeal and few visibility or public safety negatives. An inventory by C. Luginbuhl et al. of the light output and shielding of a sampling of various zoning categories (municipal, commercial, apartments, single-family residences, roadways, sports facilities, industrial, etc.), extrapolated over the entire city, yields a total output of 139 million lumens. Commercial and industrial sources account for 62% of the total. Outdoor sports lighting increases the total by 24% on summer evenings. Flagstaff's per capita lumen output is 2.5 times greater than the nominal 1,000 lumens per capita assumed by R. Garstang in his early sky glow modeling work. We resolved the discrepancy with respect to Flagstaff's measured sky glow using an improved model that includes substantial near ground attenuation by foliage and structures. A 2008 university study shows that astronomy contributes $250M annually to Arizona's economy. Another study showed that the application of lighting codes throughout Arizona could reduce energy consumption significantly. An ongoing effort led by observatory directors statewide will encourage lighting controls in currently unregulated metropolitan areas whose growing sky glow threatens observatory facilities more than 100 miles away. The national press (New York Times, the New Yorker, the Economist, USA Today, etc.) have publicized dark sky issues but frequent repetition of the essential message and vigorous action will be required to steer society toward darker skies and less egregious waste.

  11. An Innovative Collaboration on Dark Skies Education

    Science.gov (United States)

    Walker, Constance E.; Mayer, M.; EPO Students, NOAO

    2011-01-01

    Dark night skies are being lost all over the globe, and hundreds of millions of dollars of energy are being wasted in the process.. Improper lighting is the main cause of light pollution. Light pollution is a concern on many fronts, affecting safety, energy conservation, cost, human health, and wildlife. It also robs us of the beauty of viewing the night sky. In the U.S. alone, over half of the population cannot see the Milky Way from where they live. To help address this, the National Optical Astronomy Observatory Education and Public Outreach (NOAO EPO) staff created two programs: Dark Skies Rangers and GLOBE at Night. Through the two programs, students learn about the importance of dark skies and experience activities that illustrate proper lighting, light pollution's effects on wildlife and how to measure the darkness of their skies. To disseminate the programs locally in an appropriate yet innovative venue, NOAO partnered with the Cooper Center for Environmental Learning in Tucson, Arizona. Operated by the largest school district in Tucson and the University of Arizona College of Education, the Cooper Center educates thousands of students and educators each year about ecology, science, and the beauty and wonders of the Sonoran Desert. During the first academic year (2009-2010), we achieved our goal of reaching nearly 20 teachers in 40 classrooms of 1000 students. We gave two 3-hour teacher-training sessions and provided nineteen 2.5-hour on-site evening sessions on dark skies activities for the students of the teachers trained. One outcome of the program was the contribution of 1000 "GLOBE at Night 2010” night-sky brightness measurements by Tucson students. Training sessions at similar levels are continuing this year. The partnership, planning, lesson learned, and outcomes of NOAO's collaboration with the environmental center will be presented.

  12. Mira Soars Through the Sky

    Science.gov (United States)

    2007-01-01

    [figure removed for brevity, see original site] [figure removed for brevity, see original site] Figure 1Figure 2 New ultraviolet images from NASA's Galaxy Evolution Explorer shows a speeding star that is leaving an enormous trail of 'seeds' for new solar systems. The star, named Mira (pronounced my-rah) after the latin word for 'wonderful,' is shedding material that will be recycled into new stars, planets and possibly even life as it hurls through our galaxy. In figure 1, the upper panel shows Mira's full, comet-like tail as seen only in shorter, or 'far' ultraviolet wavelengths, while the lower panel is a combined view showing both far and longer, or 'near' ultraviolet wavelengths. The close-up picture at bottom gives a better look at Mira itself, which appears as a pinkish dot, and is moving from left to right in this view. Shed material appears in light blue. The dots in the picture are stars and distant galaxies. The large blue dot on the left side of the upper panel, and the large yellow dot in the lower panel, are both stars that are closer to us than Mira. The Galaxy Evolution Explorer discovered the strange tail during part of its routine survey of the entire sky at ultraviolet wavelengths. When astronomers first saw the picture, they were shocked because Mira has been studied for over 400 years yet nothing like this has ever been documented before. Mira's comet-like tail stretches a startling 13 light-years across the sky. For comparison, the nearest star to our sun, Proxima Centauri, is only about 4 light-years away. Mira's tail also tells a tale of its history -- the material making it up has been slowly blown off over time, with the oldest material at the end of the tail being released about 30,000 years ago (figure 2). Mira is a highly evolved, 'red giant' star near the end of its life. Technically, it is called an asymptotic giant branch star. It is red in color and bloated; for example, if a red giant were to replace our sun, it would engulf

  13. BIG SKY CARBON SEQUESTRATION PARTNERSHIP

    Energy Technology Data Exchange (ETDEWEB)

    Susan M. Capalbo

    2004-10-31

    The Big Sky Carbon Sequestration Partnership, led by Montana State University, is comprised of research institutions, public entities and private sectors organizations, and the Confederated Salish and Kootenai Tribes and the Nez Perce Tribe. Efforts under this Partnership fall into four areas: evaluation of sources and carbon sequestration sinks; development of GIS-based reporting framework; designing an integrated suite of monitoring, measuring, and verification technologies; and initiating a comprehensive education and outreach program. At the first two Partnership meetings the groundwork was put in place to provide an assessment of capture and storage capabilities for CO{sub 2} utilizing the resources found in the Partnership region (both geological and terrestrial sinks), that would complement the ongoing DOE research. During the third quarter, planning efforts are underway for the next Partnership meeting which will showcase the architecture of the GIS framework and initial results for sources and sinks, discuss the methods and analysis underway for assessing geological and terrestrial sequestration potentials. The meeting will conclude with an ASME workshop. The region has a diverse array of geological formations that could provide storage options for carbon in one or more of its three states. Likewise, initial estimates of terrestrial sinks indicate a vast potential for increasing and maintaining soil C on forested, agricultural, and reclaimed lands. Both options include the potential for offsetting economic benefits to industry and society. Steps have been taken to assure that the GIS-based framework is consistent among types of sinks within the Big Sky Partnership area and with the efforts of other western DOE partnerships. Efforts are also being made to find funding to include Wyoming in the coverage areas for both geological and terrestrial sinks and sources. The Partnership recognizes the critical importance of measurement, monitoring, and verification

  14. The night sky companion a yearly guide to sky-watching 2008-2009

    CERN Document Server

    Plotner, Tammy

    2007-01-01

    The Night Sky Companion is a comprehensive guide to what can be explored in the heavens on a nightly basis. Designed to appeal to readers at all skill levels, it provides a digest for sky watchers interested in all types of astronomical information.

  15. PePSS - A portable sky scanner for measuring extremely low night-sky brightness

    Science.gov (United States)

    Kocifaj, Miroslav; Kómar, Ladislav; Kundracik, František

    2018-05-01

    A new portable sky scanner designed for low-light-level detection at night is developed and employed in night sky brightness measurements in a rural region. The fast readout, adjustable sensitivity and linear response guaranteed in 5-6 orders of magnitude makes the device well suited for narrow-band photometry in both dark areas and bright urban and suburban environments. Quasi-monochromatic night-sky brightness data are advantageous in the accurate characterization of spectral power distribution of scattered and emitted light and, also allows for the possibility to retrieve light output patterns from whole-city light sources. The sky scanner can operate in both night and day regimes, taking advantage of the complementarity of both radiance data types. Due to its inherent very high sensitivity the photomultiplier tube could be used in night sky radiometry, while the spectrometer-equipped system component capable of detecting elevated intensities is used in daylight monitoring. Daylight is a source of information on atmospheric optical properties that in turn are necessary in processing night sky radiances. We believe that the sky scanner has the potential to revolutionize night-sky monitoring systems.

  16. A partial-wave analysis of the 3 pi system in the reaction K/sup -/p to pi /sup +/ pi /sup -/ pi /sup 0/ Lambda at 42 GeV/c

    CERN Document Server

    Cerrada, M; Chaloupka, V; Foster, B; Heinen, P M; Hemingway, R J; Holmgren, S O; Kittel, E W; Losty, Michael J; Massaro, G G G; Metzger, W J; Vergeest, J S M; Wagner, F; Wells, J; Wolters, G F

    1977-01-01

    A partial-wave analysis of the (3 pi )/sup 0/ system produced peripherally in the reaction K/sup -/p to pi /sup +/ pi /sup -/ pi /sup 0/ Lambda at 4.2 GeV/c is presented. The observation of the weak Lambda decay allows a determination of all the transverse production amplitudes except for two phases. The production of known resonances having decay modes other than 3 pi is used to test the isobar model ansatz. Significant omega (783), phi (1020) and A/sub 2/(1310) production is observed. The spin parity of the omega *(1675) is established as 3/sup -/. No evidence for production of other resonances, such as axial vector-mesons, is found. (23 refs).

  17. Sky coverage modeling for the whole sky for laser guide star multiconjugate adaptive optics.

    Science.gov (United States)

    Wang, Lianqi; Andersen, David; Ellerbroek, Brent

    2012-06-01

    The scientific productivity of laser guide star adaptive optics systems strongly depends on the sky coverage, which describes the probability of finding natural guide stars for the tip/tilt wavefront sensor(s) to achieve a certain performance. Knowledge of the sky coverage is also important for astronomers planning their observations. In this paper, we present an efficient method to compute the sky coverage for the laser guide star multiconjugate adaptive optics system, the Narrow Field Infrared Adaptive Optics System (NFIRAOS), being designed for the Thirty Meter Telescope project. We show that NFIRAOS can achieve more than 70% sky coverage over most of the accessible sky with the requirement of 191 nm total rms wavefront.

  18. Study of the K{sub s} decay: K{sub s} {yields} 3{pi}{sup 0} in the NA48 experiment at CERN; Etude de la desintegration K{sub s} {yields} 3{pi}{sup 0} aupres de l'experience NA48 du CERN

    Energy Technology Data Exchange (ETDEWEB)

    Gouge, G

    2003-09-01

    The study of the K{sub S} decay to three neutral pions in the NA48 experiment at CERN is presented in this thesis. This decay, which is a signature of CP violation, would yield a non-zero value of the {eta}{sub 000} parameter. The measurement of this quantity, from data samples collected by the NA48 experiment in 2000, relies on the parametrisation by {eta}{sub 000} of the K{sub S}/K{sub L} interference in the 3{pi}{sup 0} decay. The measurement is Re({eta}{sub 000}) = (-2.2 {+-} 1.O{sub stat.} {+-} 1.0{sub syst.}) X 10{sup -2} Im({eta}{sub 000}) (-3.0 {+-} 1.O{sub stat.} {+-} 1.4{sub syst.}) X 10-2 with a limit on the branching fraction of the K{sub S} {yields} 3{pi}{sup 0} mode of 1.1 X 10{sup -6} with a 90 % confidence level. The precision of the measurement does not show an evidence for the observation of CP violation. Assuming CPT invariance, which states Re ({eta}{sub 000}) = Re ({epsilon}) = 1.6 X 10{sup -3}, the imaginary part of {eta}{sub 000} becomes Im({eta}{sub 000}){sub CPT} = (-1.1 {+-} 0.7{sub stat.} {+-} 0.55{sub syst.}) x 10{sup -2} with a limit on the branching fraction of 1.9 X 10{sup -7}. Besides, the {eta}{sub 000} parameter is the main contributor to the uncertainty of the CPT violating parameter Im({delta}), through the Bell-Steinberger unitarity constraint. The new measurement of {eta}{sub 000} allows to gain a factor 3 on this uncertainty, and the calculated value of this parameter becomes Im({delta}) = (0.6 {+-} 1.5) X 10{sup -5}, which does not show any sign of CPT violation, and allows a new constraint on the mass difference between the K{sup 0} and K'{sup 0} states of 3.6 X 10{sup -19} GeV, with a 90 % confidence level. (author)

  19. Excited state redox properties of phthalocyanines: influence of the axial ligand on the rates of relaxation and electron-transfer quenching of the lowest /sup 3/. pi pi. /sup */ excited state

    Energy Technology Data Exchange (ETDEWEB)

    Ferraudi, G J; Prasad, D R

    1874-01-01

    Laser flash excitations at 640 nm have been used to generate the transient spectra of the lowest-lying /sup 3/..pi pi../sup */ state of phthalocyaninatoruthenium(II) complexes. The properties of this excited state such as the properties of the maxima, lambda/sub max/ = 500 +/- 30 nm, and lifetimes, t/sub 1/2/ = 70-4500 ns, exhibit a large dependence on the electron-accepting and electron-withdrawing tendencies of the axial ligands. A similar influence was observed upon the rate of electron-transfer quenching of the /sup 3/..pi pi../sup */ state. Values between 10/sup 6/ and 10/sup 7/ dm/sup 3/ mol/sup -1/ s/sup -1/ for the self-exchange rate constant have been obtained, according to Marcus-Hush theoretical treatments, for (Ru(pc.)LL')/sup +//(/sup 3/..pi pi../sup */)(Ru(pc)LL') (L and L' = neutral axial ligands; pc = phthalocyaninate (2-)) and isoelectronic cobalt(III) and rhodium(III) couples. The redox properties of the ground and excited states are correlated with axial ligand-induced perturbations of the electronic structure.

  20. Secrets to Successful Earth and Sky Photography

    Science.gov (United States)

    Tafreshi, Babak A.

    In the absolute silence of a desert night, surrounded by an arena of celestial beauties, a gentle breeze shifts the tiny grains of sand around me. There is a patchy glow of light visible all across the eastern horizon. It is gradually ascending over the sand dunes. The glow represents billions of stars in our home galaxy rising above the horizon of our planet. I have seen such dream-like starry scenes from many locations; from the boundless dark skies of the African Sahara when the summer Milky Way was arching over giant sandstones, to the shimmering beauty of the Grand Canyon under moonlight, and the transparent skies of the Himalayas when the bright stars of winter were rising above where the highest peak on Earth (Mt. Everest) meets the sky. These are forever-engraved moments in my memory. Astrophotography is not only about recording the celestial world. It can lead you to a life of adventure and discovery (Fig. 1).

  1. Modelling and Display of the Ultraviolet Sky

    Science.gov (United States)

    Daniels, J.; Henry, R.; Murthy, J.; Allen, M.; McGlynn, T. A.; Scollick, K.

    1994-12-01

    A computer program is currently under development to model in 3D - one dimension of which is wavelength - all the known and major speculated sources of ultraviolet (900 A - 3100 A ) radiation over the celestial sphere. The software is being written in Fortran 77 and IDL and currently operates under IRIX (the operating system of the Silicon Graphics Iris Machine); all output models are in FITS format. Models along with display software will become available to the astronomical community. The Ultraviolet Sky Model currently includes the Zodiacal Light, Point Sources of Emission, and the Diffuse Galactic Light. The Ultraviolet Sky Model is currently displayed using SkyView: a package under development at NASA/ GSFC, which allows users to retrieve and display publically available all-sky astronomical survey data (covering many wavebands) over the Internet. We present a demonstration of the SkyView display of the Ultraviolet Model. The modelling is a five year development project: the work illustrated here represents product output at the end of year one. Future work includes enhancements to the current models and incorporation of the following models: Galactic Molecular Hydrogen Fluorescence; Galactic Highly Ionized Atomic Line Emission; Integrated Extragalactic Light; and speculated sources in the intergalactic medium such as Ionized Plasma and radiation from Non-Baryonic Particle Decay. We also present a poster which summarizes the components of the Ultraviolet Sky Model and outlines a further package that will be used to display the Ultraviolet Model. This work is supported by United States Air Force Contract F19628-93-K-0004. Dr J. Daniels is supported with a post-doctoral Fellowship from the Leverhulme Foundation, London, United Kingdom. We are also grateful for the encouragement of Dr Stephen Price (Phillips Laboratory, Hanscomb Air Force Base, MA)

  2. Polarization patterns of the twilight sky

    Science.gov (United States)

    Cronin, Thomas W.; Warrant, Eric J.; Greiner, Birgit

    2005-08-01

    Although natural light sources produce depolarized light, patterns of partially linearly polarized light appear in the sky due to scattering from air molecules, dust, and aerosols. Many animals, including bees and ants, orient themselves to patterns of polarization that are present in daytime skies, when the intensity is high and skylight polarization is strong and predictable. The halicitid bee Megalopta genalis inhabits rainforests in Central America. Unlike typical bees, it forages before sunrise and after sunset, when light intensities under the forest canopy are very low, and must find its way to food sources and return to its nest in visually challenging circumstances. An important cue for the orientation could be patterns of polarization in the twilight sky. Therefore, we used a calibrated digital camera to image skylight polarization in an overhead patch of sky, 87.6° across, before dawn on Barro Colorado Island in Panama, where the bees are found. We simultaneously measured the spectral properties of polarized light in a cloudless patch of sky 15° across centered on the zenith. We also performed full-sky imaging of polarization before dawn and after dusk on Lizard Island in Australia, another tropical island. During twilight, celestial polarized light occurs in a wide band stretching perpendicular to the location of the hidden sun and reaching typical degrees of polarization near 80% at wavelengths >600 nm. This pattern appears about 45 minutes before local sunrise or disappears 45 minutes after local sunset (about 20 minutes after the onset of astronomical twilight at dawn, or before its end at dusk) and extends with little change through the entire twilight period. Such a strong and reliable orientation cue could be used for flight orientation by any animal with polarization sensitivity that navigates during twilight.

  3. Age- and Brain Region-Specific Changes of Glucose Metabolic Disorder, Learning, and Memory Dysfunction in Early Alzheimer’s Disease Assessed in APP/PS1 Transgenic Mice Using 18F-FDG-PET

    Directory of Open Access Journals (Sweden)

    Xue-Yuan Li

    2016-10-01

    Full Text Available Alzheimer’s disease (AD is a leading cause of dementia worldwide, associated with cognitive deficits and brain glucose metabolic alteration. However, the associations of glucose metabolic changes with cognitive dysfunction are less detailed. Here, we examined the brains of APP/presenilin 1 (PS1 transgenic (Tg mice aged 2, 3.5, 5 and 8 months using 18F-labed fluorodeoxyglucose (18F-FDG microPET to assess age- and brain region-specific changes of glucose metabolism. FDG uptake was calculated as a relative standardized uptake value (SUVr. Morris water maze (MWM was used to evaluate learning and memory dysfunction. We showed a glucose utilization increase in multiple brain regions of Tg mice at 2 and 3.5 months but not at 5 and 8 months. Comparisons of SUVrs within brains showed higher glucose utilization than controls in the entorhinal cortex, hippocampus, and frontal cortex of Tg mice at 2 and 3.5 months but in the thalamus and striatum at 3.5, 5 and 8 months. By comparing SUVrs in the entorhinal cortex and hippocampus, Tg mice were distinguished from controls at 2 and 3.5 months. In MWM, Tg mice aged 2 months shared a similar performance to the controls (prodromal-AD. By contrast, Tg mice failed training tests at 3.5 months but failed all MWM tests at 5 and 8 months, suggestive of partial or complete cognitive deficits (symptomatic-AD. Correlation analyses showed that hippocampal SUVrs were significantly correlated with MWM parameters in the symptomatic-AD stage. These data suggest that glucose metabolic disorder occurs before onset of AD signs in APP/PS1 mice with the entorhinal cortex and hippocampus affected first, and that regional FDG uptake increase can be an early biomarker for AD. Furthermore, hippocampal FDG uptake is a possible indicator for progression of Alzheimer’s cognition after cognitive decline, at least in animals.

  4. Age- and Brain Region-Specific Changes of Glucose Metabolic Disorder, Learning, and Memory Dysfunction in Early Alzheimer's Disease Assessed in APP/PS1 Transgenic Mice Using 18F-FDG-PET.

    Science.gov (United States)

    Li, Xue-Yuan; Men, Wei-Wei; Zhu, Hua; Lei, Jian-Feng; Zuo, Fu-Xing; Wang, Zhan-Jing; Zhu, Zhao-Hui; Bao, Xin-Jie; Wang, Ren-Zhi

    2016-10-18

    Alzheimer's disease (AD) is a leading cause of dementia worldwide, associated with cognitive deficits and brain glucose metabolic alteration. However, the associations of glucose metabolic changes with cognitive dysfunction are less detailed. Here, we examined the brains of APP/presenilin 1 (PS1) transgenic (Tg) mice aged 2, 3.5, 5 and 8 months using 18 F-labed fluorodeoxyglucose ( 18 F-FDG) microPET to assess age- and brain region-specific changes of glucose metabolism. FDG uptake was calculated as a relative standardized uptake value (SUVr). Morris water maze (MWM) was used to evaluate learning and memory dysfunction. We showed a glucose utilization increase in multiple brain regions of Tg mice at 2 and 3.5 months but not at 5 and 8 months. Comparisons of SUVrs within brains showed higher glucose utilization than controls in the entorhinal cortex, hippocampus, and frontal cortex of Tg mice at 2 and 3.5 months but in the thalamus and striatum at 3.5, 5 and 8 months. By comparing SUVrs in the entorhinal cortex and hippocampus, Tg mice were distinguished from controls at 2 and 3.5 months. In MWM, Tg mice aged 2 months shared a similar performance to the controls (prodromal-AD). By contrast, Tg mice failed training tests at 3.5 months but failed all MWM tests at 5 and 8 months, suggestive of partial or complete cognitive deficits (symptomatic-AD). Correlation analyses showed that hippocampal SUVrs were significantly correlated with MWM parameters in the symptomatic-AD stage. These data suggest that glucose metabolic disorder occurs before onset of AD signs in APP/PS1 mice with the entorhinal cortex and hippocampus affected first, and that regional FDG uptake increase can be an early biomarker for AD. Furthermore, hippocampal FDG uptake is a possible indicator for progression of Alzheimer's cognition after cognitive decline, at least in animals.

  5. Circadian system functionality, hippocampal oxidative stress, and spatial memory in the APPswe/PS1dE9 transgenic model of Alzheimer disease: effects of melatonin or ramelteon.

    Science.gov (United States)

    Baño Otalora, Beatriz; Popovic, Natalija; Gambini, Juan; Popovic, Miroljub; Viña, José; Bonet-Costa, Vicent; Reiter, Russel J; Camello, Pedro Javier; Rol, Maria Ángeles; Madrid, Juan Antonio

    2012-08-01

    Alzheimer disease (AD) is a neurodegenerative disorder that primarily causes β-amyloid accumulation in the brain, resulting in cognitive and behavioral deficits. AD patients, however, also suffer from severe circadian rhythm disruptions, and the underlying causes are still not fully known. Patients with AD show reduced systemic melatonin levels. This may contribute to their symptoms, since melatonin is an effective chronobiotic and antioxidant with neuroprotective properties. Here, the authors critically assessed the effects of long-term melatonin treatment on circadian system function, hippocampal oxidative stress, and spatial memory performance in the APPswe/PS1 double transgenic (Tg) mouse model of AD. To test if melatonin MT1/MT2 receptor activation, alone, was involved, the authors chronically treated some mice with the selective MT1/MT2 receptor agonist ramelteon. The results indicate that many of the circadian and behavioral parameters measured, including oxidative stress markers, were not significantly affected in these AD mice. During the day, though, Tg controls (Tg-CON) showed significantly higher mean activity and body temperature (BT) than wild-type (WT) mice. Overall, BT rhythm amplitude was significantly lower in Tg than in WT mice. Although melatonin treatment had no effect, ramelteon significantly reduced the amplitude of the BT rhythm in Tg mice. Towards the end of the experiment, Tg mice treated with ramelteon (Tg-RAM) showed significantly higher circadian rhythm fragmentation than Tg-CON and reduced circadian BT rhythm strength. The free-running period (τ) for the BT and locomotor activity (LA) rhythms of Tg-CON was RAM compared with Tg-CON animals. These results suggest that not all aspects of the circadian system are affected in the APPswe/PS1 mice. Therefore, care should be taken when extending the results obtained in Tg mice to develop new therapies in humans. This study also revealed the complexity in the therapeutic actions of melatonin

  6. Curcumin Decreases Hyperphosphorylation of Tau by Down-Regulating Caveolin-1/GSK-3β in N2a/APP695swe Cells and APP/PS1 Double Transgenic Alzheimer's Disease Mice.

    Science.gov (United States)

    Sun, Jieyun; Zhang, Xiong; Wang, Chen; Teng, Zhipeng; Li, Yu

    2017-01-01

    Caveolin-1, the marker protein of membranal caveolae, is not only involved in cholesterol regulation, but also participates in the cleavage of amyloid [Formula: see text]-protein precursor (APP) and the generation of [Formula: see text]-amyloid peptide. It has been reported to be tightly related with Tau. In our previous studies, curcumin has been confirmed to play a neuroprotective role in Alzheimer's disease (AD), but its effects on Caveolin-1, Tau and their correlation, and the mechanism is still unknown. As such, in the present study, N2a/WT cells, N2a/APP695swe cell and six-month-old APP/PS1 double transgenic mice were enrolled. After curcumin treatment, the expression of Caveolin-1, Tau and their relationship was detected, and the potential mechanisms were explored. The results showed that in the N2a/APP695swe cells, curcumin not only decreased the number of caveolae, but also made their membrane to be thinner; and curcumin could decreased the expression of phosphorylated Tau (P-Tau(ser404)/Tau) and Caveolin-1 ([Formula: see text]), but the expression of phosphorylated GSK-3[Formula: see text] (P-GSK-3[Formula: see text]/GSK-3[Formula: see text] was increased ([Formula: see text]). In APP/PS1 transgenic mice, the same results were observed. Taken together, our data suggest that curcumin may play an important role in AD via reducing Caveolin-1, inactivating GSK-3[Formula: see text] and inhibiting the abnormal excessive phosphorylation of Tau, which will provide a new theory for AD treatment with curcumin.

  7. Automated exploitation of sky polarization imagery.

    Science.gov (United States)

    Sadjadi, Firooz A; Chun, Cornell S L

    2018-03-10

    We propose an automated method for detecting neutral points in the sunlit sky. Until now, detecting these singularities has been done manually. Results are presented that document the application of this method on a limited number of polarimetric images of the sky captured with a camera and rotating polarizer. The results are significant because a method for automatically detecting the neutral points may aid in the determination of the solar position when the sun is obscured and may have applications in meteorology and pollution detection and characterization.

  8. Effects of Different Types of Electroacupuncture on Expression of High Mobility Group Box Pro-tein-1 and Interleukin-10 in Hippocampus of APP/PS1 Mice%不同电针法对APP/PS1小鼠海马高迁移率族蛋白B1和白细胞介素-10表达的影响

    Institute of Scientific and Technical Information of China (English)

    赵江豪; 姚海江; 王远征; 卢梦晗; 李昱颉; 宋萌; 杨利娟; 刘俊彤; 李志刚

    2018-01-01

    目的 观察"通督启神"法脉冲电针与音乐电针对APP/PS1模型小鼠空间学习记忆能力及海马内炎症介质表达的影响.方法 APP/PS1双转基因雄性小鼠32只随机分为模型组(n=8)、药物组(n=8)、脉冲电针组(n=8)和音乐电针组(n=8),相同月龄C57BL/6雄性小鼠作为正常对照组(n=8).脉冲电针组与音乐电针组以各自电针仪电针百会、印堂,留针20 min,取针后点刺人中.药物组予盐酸多奈哌齐0.92 mg/kg灌胃.正常对照组、模型组与药物组以相同方法抓取束缚20 min.治疗15 d后,行Morris水迷宫测试,免疫组化观察海马高迁移率族蛋白B1(HMGB1)与白细胞介素-10(IL-10)表达,Western blotting检测海马HMGB1与IL-10的表达.结果 两个电针组从训练第4天起,逃避潜伏较模型组缩短(P0.05);海马HMGB1的表达降低(P0.05).结论 "通督启神"法脉冲电针与音乐电针均能改善APP/PS1小鼠学习记忆功能,音乐电针在抑制炎性因子表达、促进抗炎因子表达方面可能优于脉冲电针.%Objective To compare the effect of impulse electroacupuncture (impulse-EA) and music electroacupuncture (music-EA) for Tongdu Qishen on spatial learning and memory, and expression of cytokine in the hippocampus of APP/PS1 mice. Methods A total of 32 APP/PS1 double transgenic male mice were randomly divided into model group (n=8), drug group (n=8), impulse-EA group (n=8) and music-EA group (n=8), the same background and age male C57BL/6 mice were observed as normal group (n=8). The impulse-EA group and music-EA group accepted EA at Baihui (GV20) and Yintang (GV29), connected with their own electroacupuncture stimulators, for 20 minuts, then, they were pricked Renzhong (GV26) for a while. The drug group accepted donepezil hydrochloride 0.92 mg/kg intra-gastrically. The normal group, model group and drug group were grabbed and bounded in the same way. After 15 days of treatment, they were assessed with Morris water maze. The expression of

  9. Sirius brightest diamond in the night sky

    CERN Document Server

    Holberg, Jay B

    2007-01-01

    This book describes why Sirius has been regarded as an important fixture of the night sky since the beginnings of history. It also examines the part that Sirius has played in how we came to achieve our current scientific understanding of stars.

  10. Why Is the Sky Dark at Night?

    Science.gov (United States)

    Stinner, Arthur

    2014-01-01

    The puzzle as to just why the sky is dark at night, given that there are so many stars, has been around at least since Newton. This article summarizes six cosmological models that have been used to attempt to give an account of this puzzle including the Copernican universe, the Newton-Halley universe, the nineteenth century "one galaxy"…

  11. ESASky: All the sky you need

    Science.gov (United States)

    De Marchi, Guido; ESASky Team

    2018-06-01

    ESASky is a discovery portal giving to all astronomers, professional and amateur alike, an easy way to access high-quality scientific data from their computer, tablet, or mobile device. It includes over half a million images, 300,000 spectra, and more than a billion catalogue sources. From gamma rays to radio wavelengths, it allows users to explore the cosmos with data from a dozen space missions from the astronomical archives of ESA, NASA, and JAXA and does not require prior knowledge of any particular mission. ESASky features an all-sky exploration interface, letting users easily zoom in for stars as single targets or as part of a whole galaxy, visualise them and retrieve the relevant data taken in an area of the sky with just a few clicks. Users can easily compare observations of the same source obtained by different space missions at different times and wavelengths. They can also use ESASky to plan future observations with the James Webb Space Telescope, comparing the relevant portion of the sky as observed by Hubble and other missions. We will illustrate the many options to visualise and access astronomical data: interactive footprints for each instrument, tree-maps, filters, and solar-system object trajectories can all be combined and displayed. The most recent version of ESASky, released in February, also includes access to scientific publications, allowing users to visualise on the sky all astronomical objects with associated scientific publications and to link directly back to the papers in the NASA Astrophysics Data System.

  12. DESCQA: Synthetic Sky Catalog Validation Framework

    Science.gov (United States)

    Mao, Yao-Yuan; Uram, Thomas D.; Zhou, Rongpu; Kovacs, Eve; Ricker, Paul M.; Kalmbach, J. Bryce; Padilla, Nelson; Lanusse, François; Zu, Ying; Tenneti, Ananth; Vikraman, Vinu; DeRose, Joseph

    2018-04-01

    The DESCQA framework provides rigorous validation protocols for assessing the quality of high-quality simulated sky catalogs in a straightforward and comprehensive way. DESCQA enables the inspection, validation, and comparison of an inhomogeneous set of synthetic catalogs via the provision of a common interface within an automated framework. An interactive web interface is also available at portal.nersc.gov/project/lsst/descqa.

  13. Microscopic dust in the infrared sky

    International Nuclear Information System (INIS)

    Leene, A.; Wesselius, P.

    1985-01-01

    After ten months of observation IRAS (InfraRed Astronomical Satellite) revealed for the first time an infrared sky map. One of its major discovery has been the display of new constituents in Universe: the infrared cirrus which are interstellar clouds constituted of microparticles abounding in carbon. Results and first hypothesis are presented in this article [fr

  14. Go-To Telescopes Under Suburban Skies

    CERN Document Server

    Monks, Neale

    2010-01-01

    For the last four centuries stargazers have turned their telescopes to the night skies to look at its wonders, but only in this age of computers has it become possible to let the telescope find for you the object you are looking for! So-called “go-to” telescopes are programmed with the locations of thousands of objects, including dazzling distant Suns, stunning neighboring galaxies, globular and open star clusters, the remnants of past supernovae, and many other breathtaking sights. This book does not tell you how to use your Go-to telescope. Your manual will help you do that. It tells you what to look for in the deep sky and why, and what equipment to best see it with. Organized broadly by what is best for viewing in the northern hemisphere in different seasons, Monks further divides the sights of each season into groupings such as “Showpiece Objects,” “Interesting Deep Sky Objects,” and “Obscure and Challenging Deep Sky Objects.” He also tells what objects are visible even in light-polluted ...

  15. NRAO Makes Available VLA Sky Survey Maps

    Science.gov (United States)

    1994-06-01

    An original and comprehensive data set potentially full of scientific surprises now is available to astronomers, students and the public through the information superhighway. Radio images of the sky produced by the Very Large Array radio telescope -- one of the premier astronomical instruments in the world -- as part of a massive survey now are stored in an electronic repository avail- able over the Internet computer communications network. "Each of these sensitive new sky maps shows about a thou- sand radio-emitting objects, most of which have never been seen before," said Dr. J. J. Condon, leader of the National Radio As- tronomy Observatory (NRAO) survey team. "We are releasing them as soon as they are completed because they contain more data than we could possibly analyze by ourselves." "By using electronic distribution, we can open this tre- mendous resource of information for computer analysis by all as- tronomers immediately, without waiting for traditional publication," Condon added. The radio images are copyright NRAO/ AUI. Permission is granted for use of the material without charge for scholarly, educational and private non-commercial purposes. "It is entirely conceivable -- even probable -- that valuable discoveries will be made by students or amateur astrono- mers who devote the time to study these maps carefully," said team member Dr. W. D. Cotton. "Making this new information available electronically means that more people can participate in adding to its scientific value." The maps are a product of the NRAO VLA Sky Survey (NVSS), which began its observational phase in September of 1993 and will cover 82 percent of the sky when completed by the end of 1996. The NVSS is expected to produce a catalog of more than two million ra- dio-emitting objects in the sky, and it is the first sky survey sensitive to linearly polarized emission from radio sources beyond our own Milky Way galaxy. "The NVSS is being made as a service to the entire astronomical

  16. SkyNet: Modular nuclear reaction network library

    Science.gov (United States)

    Lippuner, Jonas; Roberts, Luke F.

    2017-10-01

    The general-purpose nuclear reaction network SkyNet evolves the abundances of nuclear species under the influence of nuclear reactions. SkyNet can be used to compute the nucleosynthesis evolution in all astrophysical scenarios where nucleosynthesis occurs. Any list of isotopes can be evolved and SkyNet supports various different types of nuclear reactions. SkyNet is modular, permitting new or existing physics, such as nuclear reactions or equations of state, to be easily added or modified.

  17. Light pollution: Assessment of sky glow on two dark sky regions of Portugal.

    Science.gov (United States)

    Lima, Raul Cerveira; Pinto da Cunha, José; Peixinho, Nuno

    2016-01-01

    Artificial light at night (ALAN), producing light pollution (LP), is not a matter restricted to astronomy anymore. Light is part of modern societies and, as a consequence, the natural cycle day-night (bright-dark) has been interrupted in a large segment of the global population. There is increasing evidence that exposure to certain types of light at night and beyond threshold levels may produce hazardous effects to humans and the environment. The concept of "dark skies reserves" is a step forward in order to preserve the night sky and a means of enhancing public awareness of the problem of spread of light pollution worldwide. The aim of this study was to assess the skyglow at two sites in Portugal, the Peneda-Gerês National Park (PNPG) and the region now known as Dark Sky Alqueva Reserve. The latter site was classified as a "Starlight Tourism Destination" by the Starlight Foundation (the first in the world to achieve this classification) following a series of night sky measurements in situ described herein. The measurements at PNPG also contributed to the new set of regulations concerning light pollution at this national park. This study presents the first in situ systematic measurements of night sky brightness, showing that at the two sites the skies are mostly in levels 3 to 4 of the Bortle 9-level scale (with level 1 being the best achievable). The results indicate that the sources of light pollution and skyglow can be attributed predominantly to contamination from nearby urban regions.

  18. Huannao Yicong Formula(还脑益聪方) Regulates γ-Secretase Activity through APH-1 and PEN-2 Gene Ragulation Pathways in Hippocampus of APP/PS1 Double Transgenic Mice

    Institute of Scientific and Technical Information of China (English)

    WANG Zhi-yong; LIU Jian-gang; WEI Yun; LIU Mei-xia; WANG Qi; LIANG Lin; YANG Hui-min; LI Hao

    2017-01-01

    Objective:To observe the effects of Huannao Yicong Formula(还脑益聪方, HYF) on learning and memory and it's regulating effect on γ,-secretase related anterior pharynx defective 1 (APH-1),presenilin enhancer-2 (PEN-2) signaling pathway,so as to discuss and further clarify the mechanism of HYF on Alzheimer's disease.Methods:Sixty APP/PS1 transgenic mice,randomly allocated into 4 groups,the model group,the donepezil group (0.65 mg/kg),HYF low-dose group (HYF-L,5.46 g/kg) and HYF high-dose group (HYF-H,10.92 g/kg),15 for each group.Another 15 C57BL/6J mice with the same age and same genetic background were allocated into the control group,proper dosage of drugs or distilled water were given by intragastric administration once daily for 12 weeks.After 12 weeks of administration,the learning and memory abilities of mice in each group was evaluated by the morris water maze test,amyloid precursor protein (APP),A β1-40 and A β1-42 levels in hippocampus were detected by enzyme-linked immunosorbent assay,γ-secretase was detected by dual luciferase assaying,the levels of APH-1a,hypoxia-inducible factor 1 α (HIF-1 α),cAMP response element-binding protein (CREB) and PEN-2 and their mRNA expression was measured by Western blot and real-time polymerase chain reaction.Resuits:HYF can ameliorate learning and memory deficits in APP/PS1 transgenic mice by decreasing the escape latency,improving the number of platform crossing and swimming speed (P<0.01,P<0.05).HYF can decrease the levels of APP,A β1-40,A β1-42 and the activity of γ-secretase in hippocampus of Alzheimer's disease model mice.HYF can down-regulate the levels of CREB and PEN-2 and the expression of their mRNA.Conclusion:HYF can improve the leaming and memory ability by inhibiting the activity of γ-secretase through the CREB/PEN-2 signaling pathway,and this may be one of the therapeutic mechanisms of HYF in Alzheimer's disease.

  19. The Infrared Sky - Science from 2MASS

    International Nuclear Information System (INIS)

    Skrutskie, Michael

    2002-01-01

    The Two Micron All Sky Survey has imaged 100% of the celestial sphere in the near-infrared J (1.2 μm), H (1.6 μm) and Ks (2.2 μm) photometric bands. Pipeline processing of these data has produced catalogs containing 500 million stars and 1.5 million extended sources which will be released later this year. The catalogs are characterized by great photometric uniformity (1%) and precision (2-3%) around the sky as well as good astrometric accuracy (100 mas). This talk will focus on some of the initial scientific results enabled by this database ranging from brown dwarfs in the solar neighborhood to large scale structure in the early universe.

  20. SOUTH POL: Revealing the Polarized Southern Sky

    Science.gov (United States)

    Magalhaes, Antonio Mario Mario; Ramírez, Edgar; Ribeiro, Nadili; Seriacopi, Daiane; Rubinho, Marcelo; Ferrari, Tiberio; Rodrigues, Claudia; Schoenell, William; Herpich, Fabio; Pereyra, Antonio

    2018-01-01

    SOUTH POL will be a survey of the Southern sky in optical polarized light. It will use a newly built polarimeter for T80-S, an 84 cm robotic telescope installed at Cerro Tololo (CTIO), Chile. It will initially cover the sky South of declination -15 deg with a polarimetric accuracy Solar System.The polarimeter has just been commissioned in mid-November, 2017. The data reduction pipeline has already been built. We will describe the instrument and the data reduction, as well as a few of the science cases. The survey is expected to begin midway through the 1st semester of 2018. Both catalog data and raw images will be made available.

  1. Tropospheric haze and colors of the clear daytime sky.

    Science.gov (United States)

    Lee, Raymond L

    2015-02-01

    To casual observers, haze's visible effects on clear daytime skies may seem mundane: significant scattering by tropospheric aerosols visibly (1) reduces the luminance contrast of distant objects and (2) desaturates sky blueness. However, few published measurements of hazy-sky spectra and chromaticities exist to compare with these naked-eye observations. Hyperspectral imaging along sky meridians of clear and hazy skies at one inland and two coastal sites shows that they have characteristic colorimetric signatures of scattering and absorption by haze aerosols. In addition, a simple spectral transfer function and a second-order scattering model of skylight reveal the net spectral and colorimetric effects of haze.

  2. Aquarius L-Band Radiometers Calibration Using Cold Sky Observations

    Science.gov (United States)

    Dinnat, Emmanuel P.; Le Vine, David M.; Piepmeier, Jeffrey R.; Brown, Shannon T.; Hong, Liang

    2015-01-01

    An important element in the calibration plan for the Aquarius radiometers is to look at the cold sky. This involves rotating the satellite 180 degrees from its nominal Earth viewing configuration to point the main beams at the celestial sky. At L-band, the cold sky provides a stable, well-characterized scene to be used as a calibration reference. This paper describes the cold sky calibration for Aquarius and how it is used as part of the absolute calibration. Cold sky observations helped establish the radiometer bias, by correcting for an error in the spillover lobe of the antenna pattern, and monitor the long-term radiometer drift.

  3. Osthole Stimulated Neural Stem Cells Differentiation into Neurons in an Alzheimer's Disease Cell Model via Upregulation of MicroRNA-9 and Rescued the Functional Impairment of Hippocampal Neurons in APP/PS1 Transgenic Mice

    Directory of Open Access Journals (Sweden)

    Shao-Heng Li

    2017-06-01

    Full Text Available Alzheimer's disease (AD is the most serious neurodegenerative disease worldwide and is characterized by progressive cognitive impairment and multiple neurological changes, including neuronal loss in the brain. However, there are no available drugs to delay or cure this disease. Consequently, neuronal replacement therapy may be a strategy to treat AD. Osthole (Ost, a natural coumarin derivative, crosses the blood-brain barrier and exerts strong neuroprotective effects against AD in vitro and in vivo. Recently, microRNAs (miRNAs have demonstrated a crucial role in pathological processes of AD, implying that targeting miRNAs could be a therapeutic approach to AD. In the present study, we investigated whether Ost could enhance cell viability and prevent cell death in amyloid precursor protein (APP-expressing neural stem cells (NSCs as well as promote APP-expressing NSCs differentiation into more neurons by upregulating microRNA (miR-9 and inhibiting the Notch signaling pathway in vitro. In addition, Ost treatment in APP/PS1 double transgenic (Tg mice markedly restored cognitive functions, reduced Aβ plague production and rescued functional impairment of hippocampal neurons. The results of the present study provides evidence of the neurogenesis effects and neurobiological mechanisms of Ost against AD, suggesting that Ost is a promising drug for treatment of AD or other neurodegenerative diseases.

  4. Neuron and neuroblast numbers and cytogenesis in the dentate gyrus of aged APPswe/PS1dE9 transgenic mice: Effect of long-term treatment with paroxetine.

    Science.gov (United States)

    Olesen, Louise Ørum; Sivasaravanaparan, Mithula; Severino, Maurizio; Babcock, Alicia A; Bouzinova, Elena V; West, Mark J; Wiborg, Ove; Finsen, Bente

    2017-08-01

    Altered neurogenesis may influence hippocampal functions such as learning and memory in Alzheimer's disease. Selective serotonin reuptake inhibitors enhance neurogenesis and have been reported to reduce cerebral amyloidosis in both humans and transgenic mice. We have used stereology to assess the longitudinal changes in the number of doublecortin-expressing neuroblasts and number of granular neurons in the dentate gyrus of APP swe /PS1 dE9 transgenic mice. Furthermore, we investigated the effect of long-term paroxetine treatment on the number of neuroblasts and granular neurons, hippocampal amyloidosis, and spontaneous alternation behaviour, a measure of spatial working memory, in transgenic mice. We observed no difference in granular neurons between transgenic and wild type mice up till 18months of age, and no differences with age in wild type mice. The number of neuroblasts and the performance in the spontaneous alternation task was reduced in aged transgenic mice. Paroxetine treatment from 9 to 18months of age reduced hippocampal amyloidosis without affecting the number of neuroblasts or granular neurons. These findings suggest that the amyloidosis affects the differentiation of neuroblasts and spatial working memory, independent of changes in total granular neurons. Furthermore, while long-term paroxetine treatment may be able to reduce hippocampal amyloidosis, it appears to have no effect on total number of granular neurons or spatial working memory. Copyright © 2017 Elsevier Inc. All rights reserved.

  5. Thermography hogging the limelight at Big Sky

    Energy Technology Data Exchange (ETDEWEB)

    Plastow, C. [Fluke Electronics Canada, Mississauga, ON (Canada)

    2010-02-15

    The high levels of humidity and ammonia found at hog farms can lead to premature corrosion of electrical systems and create potential hazards, such as electrical fires. Big Sky Farms in Saskatchewan has performed on-site inspections at its 44 farms and 16 feed mills using handheld thermography technology from Fluke Electronics. Ti thermal imaging units save time and simplify inspections. The units could be used for everything, from checking out the bearings at the feed mills to electrical circuits and relays. The Ti25 is affordable and has the right features for a preventative maintenance program. Operators of Big Sky Farms use the Ti25 to inspect all circuit breakers of 600 volts or lower as well as transformers where corrosion often causes connections to break off. The units are used to look at bearings, do scanning and thermal imaging on motors. To date, the Ti25 has detected and highlighted 5 or 6 problems on transformers alone that could have been major issues. At one site, the Ti25 indicated that all 30 circuit breakers had loose connections and were overeating. Big Sky Farms fixed the problem right away before a disaster happened. In addition to reducing inspection times, the Ti25 can record all measurements and keep a record of all the readings for downloading. 2 figs.

  6. Model for the angular distribution of sky radiance

    Energy Technology Data Exchange (ETDEWEB)

    Hooper, F C; Brunger, A P

    1979-08-01

    A flexible mathematical model is introduced which describes the radiance of the dome of the sky under various conditions. This three-component continuous distribution (TCCD) model is compounded by the superposition of three separate terms, the isotropic, circumsolar and horizon brightening terms, each representing the contribution of a particular sky characteristic. In use a particular sky condition is characterized by the values of the coefficients of each of these three terms, defining the distribution of the total diffuse component. The TCCD model has been demonstrated to fit both the normalized clear sky data and the normalized overcast sky data with an RMS error of about ten percent of the man overall sky radiance. By extension the model could describe variable or partly clouded sky conditions. The model can aid in improving the prediction of solar collector performance.

  7. Solar irradiance forecasting at one-minute intervals for different sky conditions using sky camera images

    International Nuclear Information System (INIS)

    Alonso-Montesinos, J.; Batlles, F.J.; Portillo, C.

    2015-01-01

    Highlights: • The solar resource has been predicted for three hours at 1-min intervals. • Digital image levels and cloud motion vectors are joint for irradiance forecasting. • The three radiation components have been predicted under different sky conditions. • Diffuse and global radiation has an nRMSE value around 10% in all sky conditions. • Beam irradiance is predicted with an nRMSE value of about 15% in overcast skies. - Abstract: In the search for new techniques to predict atmospheric features that might be useful to solar power plant operators, we have carried out solar irradiance forecasting using emerging sky camera technology. Digital image levels are converted into irradiances and then the maximum cross-correlation method is applied to obtain future predictions. This methodology is a step forward in the study of the solar resource, essential to solar plant operators in adapting a plant’s operating procedures to atmospheric conditions and to improve electricity generation. The results are set out using different statistical parameters, in which beam, diffuse and global irradiances give a constant normalized root-mean-square error value over the time interval for all sky conditions. The average measure is 25.44% for beam irradiance; 11.60% for diffuse irradiance and 11.17% for global irradiance.

  8. The interactive sky: a browsable allsky image

    Science.gov (United States)

    Tancredi, Gonzalo; Da Rosa, Fernando; Roland, Santiago; Almenares, Luciano; Gomez, Fernando

    2015-08-01

    We are conducting a project to make available panoramas of the night sky of the southern hemisphere, based on a mosaic of hundred of photographs. Each allsky panorama is a giant image composed by hundreds of high-resolution photos taken in the course of one night. The panoramas are accessible with a web-browser and the public is able to zoom on them and to see the sky with better quality than the naked eye. We are preparing 4 sets of panoramas corresponding to the four seasons.The individual images are taken with a 16 Mpixels DLSR camera with a 50 mm lens mounted on a Gigapan EPIC robotic camera mounts. These devices and a autoguiding telescope are mounted in a equatorial telescope mount, which allows us to have exposure of several tens seconds. The images are then processed and stitched to create the gigantic panorama, with typical weight of several GBytes.The limiting magnitude is V~8. The panoramas include more than 50 times more stars those detected with the naked eye.In addition to the allsky panoramas, we embedded higher resolution images of specific regions of interest such as: emission nebulae and dark, open and globular clusters and galaxies; which can be zoomed.The photographs have been acquiring since December 2014 in a dark place with low light pollution in the countryside of Uruguay; which allows us to achieve deep sky objects.These panoramas will be available on a website and can be accessed with any browser.This tool will be available for teaching purposes, astronomy popularization or introductory research. Teacher guides will be developed for educational activities at different educational levels.While there are similar projects like Google Sky, the methodology used to generate the giant panoramas allows a much more realistic view, with a background of continuous sky without sharp edges. Furthermore, while the planetarium software is based on drawings of the stars, our panoramas are based on real images.This is the first project with these

  9. Teach and Touch the Earth and Sky

    Science.gov (United States)

    Florina Tendea, Camelia

    2017-04-01

    My name is Camelia Florina Tendea. I am primary school teacher at "Horea, Closca and Crisan" Secondary School, in Brad, a town in the west side of Transylvania. I am permanently interested to develop my knowledge and teaching skills about space sciences (Earth and Sky) because the new generations of students are very well informed and couriouse about these topics. In this context the teachers must be prepared to deal with such requests in school. Introducing of activity: For a primary school teacher is a real challenge teaching about Earth and Sky, so I consider that a collaboration with science teachers, engineers and other specialists in the sciences is absolutely essential and beneficial in the educational design. In my opinion, the contents about Earth ans Sky-Space in a single word- are very attractive for students and they are a permanent source of discoveries and provide a multidisciplinary vision, so required in the education. Possible contents to teach in primary school: about Earth: -Terra -the third Planet from the Sun; How Earth spins; Land and water; The Earth seen from space, Trip between Earth and Moon,Weather Phenomena; the Poles; about Sky: Solar System, Asteroids, Comets, Meteorites; Rosetta Mission or rendez-vous with a comet; Sun.Moon. Earth. Eclipse;Light Pollution and protection of the night sky; Life in Space. Astronauts and experiences; Mission X:- Train Like an Astronaut;About ISS. For teachers it is important to know from the beginning how they teach, a viable support is the teaching of STEM subjects, which provides access to careers in astronomy, science/technology space. We could teach about earth and sky using different kinds of experiments, simulations, hands-on activities, competitions, exhibitions, video presentations. Competences developed in primary school through these contents: Comunication, individual studying, understanding and valorisation of scientific information, relating to the natural environment. In addition, they are

  10. Determination of excitation temperature and vibrational temperature of the N{sub 2}(C {sup 3}{pi}{sub u}, {nu}') state in Ne-N{sub 2} RF discharges

    Energy Technology Data Exchange (ETDEWEB)

    Rehman, N U; Naveed, M A; Zakaullah, M [Department of Physics, Quaid-i-Azam University, 45320 Islamabad (Pakistan); Khan, F U [Department of Physics, Gomal University D.I. Khan (Pakistan)

    2008-05-01

    Optical emission spectroscopy is used to investigate the effect of neon mixing on the excitation and vibrational temperatures of the second positive system in nitrogen plasma generated by a 13.56 MHz RF generator. The excitation temperature is determined from Ne I line intensities, using Boltzmann's plot. The overpopulation of the levels of the N{sub 2} (C {sup 3}{pi}{sub u}, {nu}') states with neon mixing are monitored by measuring the emission intensities of the second positive system of nitrogen molecules. The vibrational temperature is calculated for the sequence {delta}{nu} = -2, with the assumption that it follows Boltzmann's distribution. But due to overpopulation of levels, e.g. 1, 4, a linearization process was employed for such distributions allowing us to calculate the vibrational temperature of the N{sub 2} (C {sup 3}{pi}{sub u}, {nu}') state. It is found that the excitation temperature as well as the vibrational temperature of the second positive system can be raised significantly by mixing neon with nitrogen plasma. It is also found that the vibrational temperature increases with power and pressure up to 0.5 mbar.

  11. VLITE Surveys the Sky: A 340 MHz Companion to the VLA Sky Survey (VLASS)

    Science.gov (United States)

    Peters, Wendy; Clarke, Tracy; Brisken, Walter; Cotton, William; Richards, Emily E.; Giacintucci, Simona; Kassim, Namir

    2018-01-01

    The VLA Low Band Ionosphere and Transient Experiment (VLITE; ) is a commensal observing system on the Karl G. Janksy Very Large Array (VLA) which was developed by the Naval Research Laboratory and NRAO. A 64 MHz sub-band from the prime focus 240-470 MHz dipoles is correlated during nearly all regular VLA observations. VLITE uses dedicated samplers and fibers, as well as a custom designed, real-time DiFX software correlator, and requires no additional resources from the VLA system running the primary science program. The experiment has been operating since November 2014 with 10 antennas; a recent expansion in summer 2017 increased that number to 16 and more than doubled the number of baselines.The VLA Sky Survey (VLASS; ), is an ongoing survey of the entire sky visible to the VLA at a frequency of 2-4 GHz. The observations are made using an "on-the-fly" (OTF) continuous RA scanning technique which fills in the sky by observing along rows of constant declination. VLITE breaks the data into 2-second integrations and correlates these at a central position every 1.5 degrees. All data for each correlator position is imaged separately, corrected and weighted by an appropriately elongated primary beam model, and then combined in the image plane to create a mosaic of the sky. A catalog of the sources is extracted to provide a 340 MHz sky model.We present preliminary images and catalogs from the 2017 VLASS observations which began in early September, 2017, and continued on a nearly daily basis throughout the fall. In addition to providing a unique sky model at 340 MHz, these data complement VLASS by providing spectral indices for all cataloged sources.

  12. Causality and skies: is non-refocussing necessary?

    International Nuclear Information System (INIS)

    Bautista, A; Ibort, A; Lafuente, J

    2015-01-01

    The causal structure of a strongly causal, null pseudo-convex, space-time M is completely characterized in terms of a partial order on its space of skies defined by means of a class of non-negative Legendrian isotopies called sky isotopies. It is also shown that such partial order is determined by the class of future causal celestial curves, that is, curves in the space of light rays which are tangent to skies and such that they determine non-negative sky isotopies. It will also be proved that the space of skies Σ equipped with Low’s (or reconstructive) topology is homeomorphic and diffeomorphic to M under the only additional assumption that M separates skies, that is, that different events determine different skies. The sky-separating property of M is sharp and the previous result provides an answer to the question about the class of space-times whose causal structure, topological and differentiable structure can be reconstructed from their spaces of light rays and skies. These results can be understood as a Malament–Hawking-like theorem stated in terms of the partial order defined on the space of skies. (paper)

  13. Dark Skies Awareness Programs for the International Year of Astronomy

    Science.gov (United States)

    Walker, C. E.; Pompea, S. M.

    2008-12-01

    The loss of a dark night sky as a natural resource is a growing concern. It impacts not only astronomical research, but also our environment in terms of ecology, health, safety, economics and energy conservation. For this reason, "Dark Skies are a Universal Resource" is a cornerstone project for the U.S. International Year of Astronomy (IYA) program in 2009. Its goal is to raise public awareness of the impact of artificial lighting on local environments by getting people involved in a variety of dark skies-related programs. These programs focus on citizen-scientist sky-brightness monitoring programs, a planetarium show, podcasting, social networking, a digital photography contest, the Good Neighbor Lighting Program, Earth Hour, National Dark Skies Week, a traveling exhibit, a video tutorial, Dark Skies Discovery Sites, Astronomy Nights in the (National) Parks, Sidewalk Astronomy, and a Quiet Skies program. Many similar programs are available internationally through the "Dark Skies Awareness" Global Cornerstone Project. Working groups for both the national and international dark skies cornerstone projects are being chaired by the National Optical Astronomy Observatory (NOAO). The presenters from NOAO will provide the "know-how" and the means for session participants to become community advocates in promoting Dark Skies programs as public events at their home institutions. Participants will be able to get information on jump-starting their education programs through the use of well-developed instructional materials and kits. For more information, visit http://astronomy2009.us/darkskies/ and http://www.darkskiesawareness.org/.

  14. Tat-haFGF14–154 Upregulates ADAM10 to Attenuate the Alzheimer Phenotype of APP/PS1 Mice through the PI3K-CREB-IRE1α/XBP1 Pathway

    Directory of Open Access Journals (Sweden)

    Tian Meng

    2017-06-01

    Full Text Available Acid fibroblast growth factor (aFGF has shown neuroprotection in Alzheimer’s disease (AD models in previous studies, yet its mechanism is still uncertain. Here we report that the efficacy of Tat-haFGF14–154 is markedly increased when loaded cationic liposomes for intranasal delivery are intranasally administered to APP/PS1 mice. Our results demonstrated that liposomal Tat-haFGF14–154 treatment significantly ameliorated behavioral deficits, relieved brain Aβ burden, and increased the expression and activity of disintegrin and metalloproteinase domain-containing protein 10 (ADAM10 in the brain. Tat-haFGF14–154 antagonized Aβ1–42-induced cell death and structural damage in rat primary neurons in an ADAM10-dependent manner, which, in turn, was promoted by the activation of XBP1 splicing and modulated by the PI3K-CREB pathway. Both knockdown of ADAM10 and inhibition of PI3K (LY294002 negated Tat-haFGF14–154 rescue. Thus, Tat-haFGF14–154 activates the IRE1α/XBP1 pathway of the unfolded protein response (UPR against the endoplasmic reticulum (ER stress induced by Aβ, and, subsequently, the nuclear translocation of spliced XBP1 (XBP1s promotes transcription of ADAM10. These results highlight the important role of ADAM10 and its activation through the PI3K-CREB-IRE1α/XBP1 pathway as a key factor in the mechanism of neuroprotection for Tat-haFGF14–154.

  15. The SPHEREx All-Sky Spectroscopic Survey

    Science.gov (United States)

    Unwin, Stephen C.; SPHEREx Science Team, SPHEREx Project Team

    2016-06-01

    SPHEREx is a mission to conduct an optical-near-IR survey of the entire sky with a spectrum at every pixel location. It was selected by NASA for a Phase A study in its Small Explorer Program; if selected, development would begin in 2016, and the observatory would start a 2-year prime mission in 2020. An all-sky spectroscopic survey can be used to tackle a wide range of science questions. The SPHEREx science team is focusing on three: (1) Probing the physics of inflation through measuring non-Gaussianity from the study of large-scale structure; (2) Studying the origin of water and biogenic molecules in a wide range of physical and chemical environments via ice absorption spectra; (3) Charting the history of star formation in the universe through intensity mapping of the large-scale spatial power. The instrument is a small wide-field telescope operating in the range of 0.75 - 4.8 µm at a spectral resolution of 41.5 in the optical and 150 at the long-wavelength end. It observes in a sun-sync low-earth orbit, covering the sky like WISE and COBE. SPHEREx is a simple instrument that requires no new technology. The Phase A design has substantial technical and resource margins and can be built with low risk. It is a partnership between Caltech and JPL, with Ball Aerospace and the Korea Astronomy and Space Science Institute as major partners. This research was carried out at the Jet Propulsion Laboratory, California Institute of Technology, under a contract with the National Aeronautics and Space Administration.

  16. The fast transient sky with Gaia

    Science.gov (United States)

    Wevers, Thomas; Jonker, Peter G.; Hodgkin, Simon T.; Kostrzewa-Rutkowska, Zuzanna; Harrison, Diana L.; Rixon, Guy; Nelemans, Gijs; Roelens, Maroussia; Eyer, Laurent; van Leeuwen, Floor; Yoldas, Abdullah

    2018-01-01

    The ESA Gaia satellite scans the whole sky with a temporal sampling ranging from seconds and hours to months. Each time a source passes within the Gaia field of view, it moves over 10 charge coupled devices (CCDs) in 45 s and a light curve with 4.5 s sampling (the crossing time per CCD) is registered. Given that the 4.5 s sampling represents a virtually unexplored parameter space in optical time domain astronomy, this data set potentially provides a unique opportunity to open up the fast transient sky. We present a method to start mining the wealth of information in the per CCD Gaia data. We perform extensive data filtering to eliminate known onboard and data processing artefacts, and present a statistical method to identify sources that show transient brightness variations on ≲2 h time-scales. We illustrate that by using the Gaia photometric CCD measurements, we can detect transient brightness variations down to an amplitude of 0.3 mag on time-scales ranging from 15 s to several hours. We search an area of ∼23.5 deg2 on the sky and find four strong candidate fast transients. Two candidates are tentatively classified as flares on M-dwarf stars, while one is probably a flare on a giant star and one potentially a flare on a solar-type star. These classifications are based on archival data and the time-scales involved. We argue that the method presented here can be added to the existing Gaia Science Alerts infrastructure for the near real-time public dissemination of fast transient events.

  17. 1H-MR spectroscopy in evaluating the effect of neural stem cell transplantation on Alzheimer's disease in an APP-PS1 transgenic mouse model

    International Nuclear Information System (INIS)

    Chen Shuangqing; Cai Qing; Shen Yuying; Li Minghua; Zhang Wei; Wang Peijun; Zang Fengchao; Teng Gaojun

    2012-01-01

    Objective: To explore the value of 1 H-MRS on the evaluation of Alzheimer's disease (AD) with neural stem cells (NSCs) transplantation in an APP-PS1 double transgenic (tg) AD mouse model. Methods: NSCs from C57BL/6 mice were cultured and amplified.APP-PS1 tg mice (n =30) aged 12 months were used as the study group, and mild-type mice (n=15) were used as the control group. Animals in the study group were randomized into two subgroups, the AD mice in one subgroup received NSCs transplantation (NSCs group) and in another subgroup received phosphate buffer saline (PBS, PBS group)in bilateral hippocampal CA1. Animals in the control group were not treated. Using a 7.0 T high-field strength MR imager, 1 H-MRS was performed before and 6 weeks after transplantation to measure the area under the peak of n-acetyl aspartate (NAA),glutamate (Glu), myo-inositol (mI), choline (Cho) and creatine (Cr) in the hippocampal area, NAA/Cr, Glu/Cr, mI/Cr and Cho/Cr ratio were calculated and compared with histopathological results (including Nissl's staining and electron microscope examination). Comparisons among NSCs, PBS and control groups were conducted by one-way ANOVA. Results: NSCs from C57BL/6 mice were cultured successfully. Before transplantation,the mean NAA/Cr, Glu/Cr and mI/Cr in NSCs, PBS and control groups were 0.89 ± 0.05, 0.88 ± 0.04 and 1.15 ± 0.05, 0.40 ± 0.03, 0.39 ± 0.03 and 0.45 ± 0.05, 0.67 ± 0.05, 0.67 ± 0.05 and 0.52 ± 0.04, respectively, and differences were statistically significant (F =148.918,7.529,59.468,P<0.01). There were no significant differences in NAA/Cr,mI/Cr and Glu/Cr ratios between NSCs and PBS groups before transplantation (t=0.147, 0.096, 0.207, P>0.05), but the differences were significant compared with the control group (t=0.255, 0.467, 0.171 and t=0.269, 0.527, 0.151, P<0.05). Six weeks after transplantation,the mean NAA/Cr, Glu/Cr and mI/Cr in three groups were 1.13 ±0.07, 0.86 ±0.05 and 1.14 ±0.05, 0.45 ± 0.04, 0.38 ± 0

  18. ACTPol: On-Sky Performance and Characterization

    Science.gov (United States)

    Grace, E.; Beall, J.; Bond, J. R.; Cho, H. M.; Datta, R.; Devlin, M. J.; Dunner, R.; Fox, A. E.; Gallardo, P.; Hasselfield, M.; hide

    2014-01-01

    ACTPol is the polarization-sensitive receiver on the Atacama Cosmology Telescope. ACTPol enables sensitive millimeter wavelength measurements of the temperature and polarization anisotropies of the Cosmic Microwave Background (CMB) at arcminute angular scales. These measurements are designed to explore the process of cosmic structure formation, constrain or determine the sum of the neutrino masses, probe dark energy, and provide a foundation for a host of other cosmological tests. We present an overview of the first season of ACTPol observations focusing on the optimization and calibration of the first detector array as well as detailing the on-sky performance.

  19. The SPHEREx All-Sky Spectral Survey

    Science.gov (United States)

    Bock, James; SPHEREx Science Team

    2018-01-01

    SPHEREx, a mission in NASA's Medium Explorer (MIDEX) program that was selected for Phase A in August 2017, is an all-sky survey satellite designed to address all three science goals in NASA's astrophysics division, with a single instrument, a wide-field spectral imager. SPHEREx will probe the physics of inflation by measuring non-Gaussianity by studying large-scale structure, surveying a large cosmological volume at low redshifts, complementing high-z surveys optimized to constrain dark energy. The origin of water and biogenic molecules will be investigated in all phases of planetary system formation - from molecular clouds to young stellar systems with protoplanetary disks - by measuring ice absorption spectra. We will chart the origin and history of galaxy formation through a deep survey mapping large-scale spatial power in two deep fields located near the ecliptic poles. Following in the tradition of all-sky missions such as IRAS, COBE and WISE, SPHEREx will be the first all-sky near-infrared spectral survey. SPHEREx will create spectra (0.75 – 4.2 um at R = 41; and 4.2 – 5 um at R = 135) with high sensitivity making background-limited observations using a passively-cooled telescope with a wide field-of-view for large mapping speed. During its two-year mission, SPHEREx will produce four complete all-sky maps that will serve as a rich archive for the astronomy community. With over a billion detected galaxies, hundreds of millions of high-quality stellar and galactic spectra, and over a million ice absorption spectra, the archive will enable diverse scientific investigations including studies of young stellar systems, brown dwarfs, high-redshift quasars, galaxy clusters, the interstellar medium, asteroids and comets. All aspects of the instrument and spacecraft have high heritage. SPHEREx requires no new technologies and carries large technical and resource margins on every aspect of the design. SPHEREx is a partnership between Caltech and JPL, following the

  20. A 6-cm deep sky survey

    International Nuclear Information System (INIS)

    Fomalont, E.B.; Kellermann, K.I.; Wall, J.V.

    1983-01-01

    In order to extend radio source counts to lower flux density, the authors have used the VLA to survey a small region of sky at 4.885 GHz (6 cm) to a limiting flux density of 50 μJy. Details of this deep survey are given in the paper by kellermann et al. (these proceedings). In addition, they have observed 10 other nearby fields to a limiting flux density of 350 μJy in order to provide better statistics on sources of intermediate flux density. (Auth.)

  1. Einstein pictures the x-ray sky

    International Nuclear Information System (INIS)

    Hartline, B.K.

    1979-01-01

    The second High Energy Astronomy Observatory (HEAO-2, Einstein) is revolutionizing x-ray astronomy just as its namesake revolutionized physics. Earlier x-ray observatories, including HEAO-1, were designed to scan the sky for x-ray emitters. With Einstein, the challenge has shifted from discovering x-ray sources to understanding the processes producing the x-rays. But having 500 times the sensitivity of previous detectors, Einstein makes more than its share of discoveries, too. For example, it sees distant quasars and clusters of galaxies that can barely be detected by the largest optical telescopes

  2. Sloan Digital Sky Survey Photometric Calibration Revisited

    International Nuclear Information System (INIS)

    Marriner, John

    2012-01-01

    The Sloan Digital Sky Survey calibration is revisited to obtain the most accurate photometric calibration. A small but significant error is found in the flat-fielding of the Photometric telescope used for calibration. Two SDSS star catalogs are compared and the average difference in magnitude as a function of right ascension and declination exhibits small systematic errors in relative calibration. The photometric transformation from the SDSS Photometric Telescope to the 2.5 m telescope is recomputed and compared to synthetic magnitudes computed from measured filter bandpasses.

  3. Polygons and practice in Skies of Arcadia

    Directory of Open Access Journals (Sweden)

    Zoya Street

    2013-03-01

    Full Text Available This paper features research carried out at the Victoria and Albert Museum into the design history of Sega’s 2000 Dreamcast title, Skies of Arcadia (released in Japan as Eternal Arcadia. It was released by Overworks, a subsidiary of Sega, at an interesting point in Japanese computer game history. A new generation of video game consoles was in its infancy, and much speculation in the industry surrounded how networked gaming and large, open, tridimensional game worlds would change game design in the years ahead.

  4. The stargazer's guide to the night sky

    CERN Document Server

    Lisle, Jason, Dr

    2012-01-01

    Explore the night sky, identify stars, constellations, and even planets. Stargaze with a telescope, binoculars, or even your naked eye. Allow Dr. Jason Lisle, a research scientist with a masters and PhD in astrophysics, to guide you in examining the beauty of God's Creation with 150 full color star-charts. Learn the best ways and optimal times to observe planets and stars with easy to use illustrations. Create or expand the hobby of stargazing; an outdoor, educational hobby to enjoy with friends or family.

  5. Sloan Digital Sky Survey Photometric Calibration Revisited

    Energy Technology Data Exchange (ETDEWEB)

    Marriner, John; /Fermilab

    2012-06-29

    The Sloan Digital Sky Survey calibration is revisited to obtain the most accurate photometric calibration. A small but significant error is found in the flat-fielding of the Photometric telescope used for calibration. Two SDSS star catalogs are compared and the average difference in magnitude as a function of right ascension and declination exhibits small systematic errors in relative calibration. The photometric transformation from the SDSS Photometric Telescope to the 2.5 m telescope is recomputed and compared to synthetic magnitudes computed from measured filter bandpasses.

  6. Expression of proteins FGFR3, PI3K, AKT, p21Waf1/Cip1 and cyclins D1 and D3 in patients with T1 bladder tumours: clinical implications and prognostic significance.

    Science.gov (United States)

    Blanca Pedregosa, A M; Sánchez-González, Á; Carrasco Valiente, J; Ruiz García, J M; Gómez Gómez, E; López Beltrán, A; Requena Tapia, M J

    2017-04-01

    To determine the differential protein expression of biomarkers FGFR3, PI3K (subunits PI3Kp110α, PI3KClassIII, PI3Kp85), AKT, p21Waf1/Cip1 and cyclins D1 and D3 in T1 bladder cancer versus healthy tissue and to study their potential role as early recurrence markers. This is a prospective study that employed a total of 67 tissue samples (55 cases of T1 bladder tumours that underwent transurethral resection and 12 cases of adjacent healthy mucosa). The protein expression levels were assessed using Western blot, and the means and percentages were compared using Student's t-test and the chi-squared test. The survival analysis was conducted using the Kaplan-Meier method and the log-rank test. Greater protein expression was detected for FGFR3, PI3Kp110α, PI3KClassIII, cyclins D1 and D3 and p21Waf1/Cip1 in the tumour tissue than in the healthy mucosa. However, these differences were not significant for PI3Kp85 and AKT. We observed statistically significant correlations between early recurrence and PI3Kp110α, PI3KClassIII, PI3Kp85 and AKT (P=.003, P=.045, P=.050 and P=.028, respectively), between the tumour type (primary vs. recurrence) and cyclin D3 (P=.001), between the tumour size and FGFR3 (P=.035) and between multifocality and cyclin D1 (P=.039). The survival analysis selected FGFR3 (P=.024), PI3Kp110α (P=.014), PI3KClassIII (P=.042) and AKT (P=.008) as markers of early-recurrence-free survival. There is an increase in protein expression levels in bladder tumour tissue. The overexpression of FGFR3, PI3Kp110α, PI3KClassIII and AKT is associated with increased early-recurrence-free survival for patients with T1 bladder tumours. Copyright © 2016 AEU. Publicado por Elsevier España, S.L.U. All rights reserved.

  7. Dark Skies as a Universal Resource: Citizen Scientists Measuring Sky Brightness

    Science.gov (United States)

    Walker, C. E.; Isbell, D.; Pompea, S. M.

    2007-12-01

    The international star-hunting event known as GLOBE at Night returned March 8-21, 2007 in two flavors: the classic GLOBE at Night activity incorporating unaided-eye observations which debuted last year, and a new effort to obtain precise measurements of urban dark skies using digital sky-brightness meters. Both flavors of the program were designed to aid in heightening the awareness about the impact of artificial lighting on local environments, and the ongoing loss of a dark night sky as a natural resource for much of the world's population. To make possible the digital GLOBE at Night program, NSF funded 135 low-cost, digital sky-quality meter (manufactured by Unihedron). With these, citizen-scientists took direct measurements of the integrated sky brightness across a wide swath of night sky. Along with related materials developed by the National Optical Astronomy Observatory (NOAO), the meters were distributed to citizen-scientists in 21 U.S. states plus Washington DC, and in 5 other countries, including Chile, where NOAO has a major observatory. The citizen- scientists were selected from teachers, their students, astronomers at mountain-top observatories, International Dark-Sky Association members and staff from 19 small science centers. Most sites had a coordinator, who instructed local educators in the proper use of the meters and develop a plan to share them as widely as possible during the 2-week window. The local teams pooled their data for regional analysis and in some cases shared the results with their schools and local policymakers. Building upon the worldwide participation sparked by the first GLOBE at Night campaign in March 2006, the observations this year approached 8500 (from 60 countries), 85% higher than the number from last year. The success of GLOBE at Night 2007 is a major step toward the International Year of Astronomy in 2009, when one goal is to make the digital data collection into a worldwide activity. In this presentation, we will outline

  8. Uncertainties of parameterized surface downward clear-sky shortwave and all-sky longwave radiation.

    Science.gov (United States)

    Gubler, S.; Gruber, S.; Purves, R. S.

    2012-06-01

    As many environmental models rely on simulating the energy balance at the Earth's surface based on parameterized radiative fluxes, knowledge of the inherent model uncertainties is important. In this study we evaluate one parameterization of clear-sky direct, diffuse and global shortwave downward radiation (SDR) and diverse parameterizations of clear-sky and all-sky longwave downward radiation (LDR). In a first step, SDR is estimated based on measured input variables and estimated atmospheric parameters for hourly time steps during the years 1996 to 2008. Model behaviour is validated using the high quality measurements of six Alpine Surface Radiation Budget (ASRB) stations in Switzerland covering different elevations, and measurements of the Swiss Alpine Climate Radiation Monitoring network (SACRaM) in Payerne. In a next step, twelve clear-sky LDR parameterizations are calibrated using the ASRB measurements. One of the best performing parameterizations is elected to estimate all-sky LDR, where cloud transmissivity is estimated using measured and modeled global SDR during daytime. In a last step, the performance of several interpolation methods is evaluated to determine the cloud transmissivity in the night. We show that clear-sky direct, diffuse and global SDR is adequately represented by the model when using measurements of the atmospheric parameters precipitable water and aerosol content at Payerne. If the atmospheric parameters are estimated and used as a fix value, the relative mean bias deviance (MBD) and the relative root mean squared deviance (RMSD) of the clear-sky global SDR scatter between between -2 and 5%, and 7 and 13% within the six locations. The small errors in clear-sky global SDR can be attributed to compensating effects of modeled direct and diffuse SDR since an overestimation of aerosol content in the atmosphere results in underestimating the direct, but overestimating the diffuse SDR. Calibration of LDR parameterizations to local conditions

  9. Uncertainties of parameterized surface downward clear-sky shortwave and all-sky longwave radiation.

    Directory of Open Access Journals (Sweden)

    S. Gubler

    2012-06-01

    Full Text Available As many environmental models rely on simulating the energy balance at the Earth's surface based on parameterized radiative fluxes, knowledge of the inherent model uncertainties is important. In this study we evaluate one parameterization of clear-sky direct, diffuse and global shortwave downward radiation (SDR and diverse parameterizations of clear-sky and all-sky longwave downward radiation (LDR. In a first step, SDR is estimated based on measured input variables and estimated atmospheric parameters for hourly time steps during the years 1996 to 2008. Model behaviour is validated using the high quality measurements of six Alpine Surface Radiation Budget (ASRB stations in Switzerland covering different elevations, and measurements of the Swiss Alpine Climate Radiation Monitoring network (SACRaM in Payerne. In a next step, twelve clear-sky LDR parameterizations are calibrated using the ASRB measurements. One of the best performing parameterizations is elected to estimate all-sky LDR, where cloud transmissivity is estimated using measured and modeled global SDR during daytime. In a last step, the performance of several interpolation methods is evaluated to determine the cloud transmissivity in the night.

    We show that clear-sky direct, diffuse and global SDR is adequately represented by the model when using measurements of the atmospheric parameters precipitable water and aerosol content at Payerne. If the atmospheric parameters are estimated and used as a fix value, the relative mean bias deviance (MBD and the relative root mean squared deviance (RMSD of the clear-sky global SDR scatter between between −2 and 5%, and 7 and 13% within the six locations. The small errors in clear-sky global SDR can be attributed to compensating effects of modeled direct and diffuse SDR since an overestimation of aerosol content in the atmosphere results in underestimating the direct, but overestimating the diffuse SDR. Calibration of LDR parameterizations

  10. Deep sky observing an astronomical tour

    CERN Document Server

    Coe, Steven R

    2016-01-01

    This updated second edition has all of the information needed for your successful forays into deep sky observing. Coe uses his years of experience to give detailed practical advice about how to find the best observing site, how to make the most of the time spent there, and what equipment and instruments to take along. There are comprehensive lists of deep sky objects of all kinds, along with Steve's own observations describing how they look through telescopes with apertures ranging from 4 inches to 36 inches (0.1 - 0.9 meters). Binocular observing also gets its due, while the lists of objects have been amended to highlight only the best targets. A new index makes finding targets easier than ever before, while the selection of viewing targets has been revised from the first edition. Most of all, this book is all about how to enjoy astronomy. The author's enthusiasm and sense of wonder shine through every page as he invites you along on a tour of some of the most beautiful and fascinating sites in the deep ...

  11. Intercomparisons of nine sky brightness detectors.

    Science.gov (United States)

    den Outer, Peter; Lolkema, Dorien; Haaima, Marty; van der Hoff, Rene; Spoelstra, Henk; Schmidt, Wim

    2011-01-01

    Nine Sky Quality Meters (SQMs) have been intercompared during a night time measurement campaign held in the Netherlands in April 2011. Since then the nine SQMs have been distributed across The Netherlands and form the Dutch network for monitoring night sky brightness. The goal of the intercomparison was to infer mutual calibration factors and obtain insight into the variability of the SQMs under different meteorological situations. An ensemble average is built from the individual measurements and used as a reference to infer the mutual calibration factors. Data required additional synchronization prior to the calibration determination, because the effect of moving clouds combined with small misalignments emerges as time jitter in the measurements. Initial scatter of the individual instruments lies between ±14%. Individual night time sums range from -16% to +20%. Intercalibration reduces this to 0.5%, and -7% to +9%, respectively. During the campaign the smallest luminance measured was 0.657 ± 0.003 mcd/m(2) on 12 April, and the largest value was 5.94 ± 0.03 mcd/m(2) on 2 April. During both occurrences interfering circumstances like snow cover or moonlight were absent.

  12. SkyMine Carbon Mineralization Pilot Project

    Energy Technology Data Exchange (ETDEWEB)

    Christenson, Norm; Walters, Jerel

    2014-12-31

    This Topical Report addresses accomplishments achieved during Phase 2b of the SkyMine® Carbon Mineralization Pilot Project. The primary objectives of this project are to design, construct, and operate a system to capture CO2 from a slipstream of flue gas from a commercial coal-fired cement kiln, convert that CO2 to products having commercial value (i.e., beneficial use), show the economic viability of the CO2 capture and conversion process, and thereby advance the technology to the point of readiness for commercial scale demonstration and deployment. The overall process is carbon negative, resulting in mineralization of CO2 that would otherwise be released into the atmosphere. The project will also substantiate market opportunities for the technology by sales of chemicals into existing markets, and identify opportunities to improve technology performance and reduce costs at the commercial scale. The project is being conducted in two phases. The primary objectives of Phase 1 were to evaluate proven SkyMine® process chemistry for commercial pilot-scale operation and complete the preliminary design for the pilot plant to be built and operated in Phase 2, complete a NEPA evaluation, and develop a comprehensive carbon life cycle analysis. The objective of Phase 2b was to build the pilot plant to be operated and tested in Phase 2c.

  13. Flying Drosophila orient to sky polarization.

    Science.gov (United States)

    Weir, Peter T; Dickinson, Michael H

    2012-01-10

    Insects maintain a constant bearing across a wide range of spatial scales. Monarch butterflies and locusts traverse continents [1, 2], and foraging bees and ants travel hundreds of meters to return to their nests [1, 3, 4], whereas many other insects fly straight for only a few centimeters before changing direction. Despite this variation in spatial scale, the brain region thought to underlie long-distance navigation is remarkably conserved [5, 6], suggesting that the use of a celestial compass is a general and perhaps ancient capability of insects. Laboratory studies of Drosophila have identified a local search mode in which short, straight segments are interspersed with rapid turns [7, 8]. However, this flight mode is inconsistent with measured gene flow between geographically separated populations [9-11], and individual Drosophila can travel 10 km across desert terrain in a single night [9, 12, 13]-a feat that would be impossible without prolonged periods of straight flight. To directly examine orientation behavior under outdoor conditions, we built a portable flight arena in which a fly viewed the natural sky through a liquid crystal device that could experimentally rotate the polarization angle. Our findings indicate that Drosophila actively orient using the sky's natural polarization pattern. Copyright © 2012 Elsevier Ltd. All rights reserved.

  14. COSMO-SkyMed and GIS applications

    Science.gov (United States)

    Milillo, Pietro; Sole, Aurelia; Serio, Carmine

    2013-04-01

    Geographic Information Systems (GIS) and Remote Sensing have become key technology tools for the collection, storage and analysis of spatially referenced data. Industries that utilise these spatial technologies include agriculture, forestry, mining, market research as well as the environmental analysis . Synthetic Aperture Radar (SAR) is a coherent active sensor operating in the microwave band which exploits relative motion between antenna and target in order to obtain a finer spatial resolution in the flight direction exploiting the Doppler effect. SAR have wide applications in Remote Sensing such as cartography, surface deformation detection, forest cover mapping, urban planning, disasters monitoring , surveillance etc… The utilization of satellite remote sensing and GIS technology for this applications has proven to be a powerful and effective tool for environmental monitoring. Remote sensing techniques are often less costly and time-consuming for large geographic areas compared to conventional methods, moreover GIS technology provides a flexible environment for, analyzing and displaying digital data from various sources necessary for classification, change detection and database development. The aim of this work si to illustrate the potential of COSMO-SkyMed data and SAR applications in a GIS environment, in particular a demostration of the operational use of COSMO-SkyMed SAR data and GIS in real cases will be provided for what concern DEM validation, river basin estimation, flood mapping and landslide monitoring.

  15. SkyMine Carbon Mineralization Pilot Project

    Energy Technology Data Exchange (ETDEWEB)

    Joe Jones; Clive Barton; Mark Clayton; Al Yablonsky; David Legere

    2010-09-30

    This Topical Report addresses accomplishments achieved during Phase 1 of the SkyMine{reg_sign} Carbon Mineralization Pilot Project. The primary objectives of this project are to design, construct, and operate a system to capture CO{sub 2} from a slipstream of flue gas from a commercial coal-fired cement kiln, convert that CO{sub 2} to products having commercial value (i.e., beneficial use), show the economic viability of the CO{sub 2} capture and conversion process, and thereby advance the technology to a point of readiness for commercial scale demonstration and proliferation. The project will also substantiate market opportunities for the technology by sales of chemicals into existing markets, and identify opportunities to improve technology performance and reduce costs at commercial scale. The primary objectives of Phase 1 of the project were to elaborate proven SkyMine{reg_sign} process chemistry to commercial pilot-scale operation and complete the preliminary design ('Reference Plant Design') for the pilot plant to be built and operated in Phase 2. Additionally, during Phase 1, information necessary to inform a DOE determination regarding NEPA requirements for the project was developed, and a comprehensive carbon lifecycle analysis was completed. These items were included in the formal application for funding under Phase 2. All Phase 1 objectives were successfully met on schedule and within budget.

  16. Petyarre and Moffat: 'Looking from the Sky'

    Directory of Open Access Journals (Sweden)

    Linnell Secomb

    2013-08-01

    Full Text Available Moffatt’s Up in the Sky series draws attention to the relation between sky and earth, through the content and camera angles of the images. Similarly, Kathleen Petyarre’s Central Desert acrylic dot painting evokes this relation representing country and Dreaming from a celestial perspective—as she says ‘looking from the sky’. Yet here any association between these artists seems to end with the urban artist refusing to engage Aboriginal tradition and the desert artist focused on Dreaming, country and heritage. However, a further connection between these disparate works may also be discerned as each, in differing ways, transforms our conventional perceptions of space and time. Reading these images in relation to Walter Benjamin’s concepts of the auratic and of messianic time, I suggest that each restructures dimension and duration putting in question the (postmodern calibrations of our space/time experience. This paper stages an engagement between these artists’ works and Benjamin’s concepts exploring the variations and modifications of the spatial and the temporal that hybrid cross-cultural exchanges require and facilitate.

  17. Intercomparisons of Nine Sky Brightness Detectors

    Directory of Open Access Journals (Sweden)

    Henk Spoelstra

    2011-10-01

    Full Text Available Nine Sky Quality Meters (SQMs have been intercompared during a night time measurement campaign held in the Netherlands in April 2011. Since then the nine SQMs have been distributed across the Netherlands and form the Dutch network for monitoring night sky brightness. The goal of the intercomparison was to infer mutual calibration factors and obtain insight into the variability of the SQMs under different meteorological situations. An ensemble average is built from the individual measurements and used as a reference to infer the mutual calibration factors. Data required additional synchronization prior to the calibration determination, because the effect of moving clouds combined with small misalignments emerges as time jitter in the measurements. Initial scatter of the individual instruments lies between ±14%. Individual night time sums range from −16% to +20%. Intercalibration reduces this to 0.5%, and −7% to +9%, respectively. During the campaign the smallest luminance measured was 0.657 ± 0.003 mcd/m2 on 12 April, and the largest value was 5.94 ± 0.03 mcd/m2 on 2 April. During both occurrences interfering circumstances like snow cover or moonlight were absent.

  18. Using routine meteorological data to derive sky conditions

    Directory of Open Access Journals (Sweden)

    D. Pagès

    Full Text Available Sky condition is a matter of interest for public and weather predictors as part of weather analyses. In this study, we apply a method that uses total solar radiation and other meteorological data recorded by an automatic station for deriving an estimation of the sky condition. The impetus of this work is the intention of the Catalan Meteorological Service (SMC to provide the public with real-time information about the sky condition. The methodology for deriving sky conditions from meteorological records is based on a supervised classification technique called maximum likelihood method. In this technique we first need to define features which are derived from measured variables. Second, we must decide which sky conditions are intended to be distinguished. Some analyses have led us to use four sky conditions: (a cloudless or almost cloudless sky, (b scattered clouds, (c mostly cloudy – high clouds, (d overcast – low clouds. An additional case, which may be treated separately, corresponds to precipitation (rain or snow. The main features for estimating sky conditions are, as expected, solar radiation and its temporal variability. The accuracy of this method of guessing sky conditions compared with human observations is around 70% when applied to four sites in Catalonia (NE Iberian Peninsula. The agreement increases if we take into account the uncertainty both in the automatic classifier and in visual observations.

    Key words. Meteorological and atmospheric dynamics (instruments and techniques; radiative processes – Atmospheric composition and structure (cloud physics and chemistry

  19. Using routine meteorological data to derive sky conditions

    Directory of Open Access Journals (Sweden)

    D. Pagès

    2003-03-01

    Full Text Available Sky condition is a matter of interest for public and weather predictors as part of weather analyses. In this study, we apply a method that uses total solar radiation and other meteorological data recorded by an automatic station for deriving an estimation of the sky condition. The impetus of this work is the intention of the Catalan Meteorological Service (SMC to provide the public with real-time information about the sky condition. The methodology for deriving sky conditions from meteorological records is based on a supervised classification technique called maximum likelihood method. In this technique we first need to define features which are derived from measured variables. Second, we must decide which sky conditions are intended to be distinguished. Some analyses have led us to use four sky conditions: (a cloudless or almost cloudless sky, (b scattered clouds, (c mostly cloudy – high clouds, (d overcast – low clouds. An additional case, which may be treated separately, corresponds to precipitation (rain or snow. The main features for estimating sky conditions are, as expected, solar radiation and its temporal variability. The accuracy of this method of guessing sky conditions compared with human observations is around 70% when applied to four sites in Catalonia (NE Iberian Peninsula. The agreement increases if we take into account the uncertainty both in the automatic classifier and in visual observations.Key words. Meteorological and atmospheric dynamics (instruments and techniques; radiative processes – Atmospheric composition and structure (cloud physics and chemistry

  20. A partial-wave analysis of the neutral 3 pi system produced in the reaction pi /sup -/p to ( pi /sup +/ pi /sup -/ pi /sup 0/)n at 12 and 15 GeV/c

    CERN Document Server

    Corden, M J; Bellamy, E H; Corbett, I F; Dagan, S; Dowell, John D; Esterling, R J; Garvey, J; Gnat, Y; Green, M G; Harnew, N; Jobes, M; Kenyon, I R; Lipman, Norman H; Lister, J B; Lister, J R; Litchfield, P J; Mawson, J; McMahon, T; Robertson, A W; Stacey, B J; Strong, J A; Sumorok, K; Thomas, D H

    1978-01-01

    Data on the charge-exchange reaction pi /sup -/p to ( pi /sup +/ pi /sup -/ pi /sup 0/)n have been taken at beam momenta of 12 and 15 GeV /c, using the CERN Omega Multiparticle Spectrometer. A partial-wave analysis has been made of the (3 pi )/sup 0/ system. Both natural and unnatural spin-parity production was observed. The natural parity states can be identified with established resonances. In addition a natural spin-parity enhancement is observed at a mass of about 2 GeV/c /sup 2/ with J/sup P/=4/sup +/ preferred. This effect is called the A /sub 2/*(2030). The unnatural spin-parity production found is consistent with reggeized Deck model predictions. No unambiguous A/sub 1/ or A/sub 3/ production is observed. (15 refs).

  1. Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus.

    Science.gov (United States)

    Torres, Manuel; Jimenez, Sebastian; Sanchez-Varo, Raquel; Navarro, Victoria; Trujillo-Estrada, Laura; Sanchez-Mejias, Elisabeth; Carmona, Irene; Davila, Jose Carlos; Vizuete, Marisa; Gutierrez, Antonia; Vitorica, Javier

    2012-11-22

    Axonal pathology might constitute one of the earliest manifestations of Alzheimer disease. Axonal dystrophies were observed in Alzheimer's patients and transgenic models at early ages. These axonal dystrophies could reflect the disruption of axonal transport and the accumulation of multiple vesicles at local points. It has been also proposed that dystrophies might interfere with normal intracellular proteolysis. In this work, we have investigated the progression of the hippocampal pathology and the possible implication in Abeta production in young (6 months) and aged (18 months) PS1(M146L)/APP(751sl) transgenic mice. Our data demonstrated the existence of a progressive, age-dependent, formation of axonal dystrophies, mainly located in contact with congophilic Abeta deposition, which exhibited tau and neurofilament hyperphosphorylation. This progressive pathology was paralleled with decreased expression of the motor proteins kinesin and dynein. Furthermore, we also observed an early decrease in the activity of cathepsins B and D, progressing to a deep inhibition of these lysosomal proteases at late ages. This lysosomal impairment could be responsible for the accumulation of LC3-II and ubiquitinated proteins within axonal dystrophies. We have also investigated the repercussion of these deficiencies on the APP metabolism. Our data demonstrated the existence of an increase in the amyloidogenic pathway, which was reflected by the accumulation of hAPPfl, C99 fragment, intracellular Abeta in parallel with an increase in BACE and gamma-secretase activities. In vitro experiments, using APPswe transfected N2a cells, demonstrated that any imbalance on the proteolytic systems reproduced the in vivo alterations in APP metabolism. Finally, our data also demonstrated that Abeta peptides were preferentially accumulated in isolated synaptosomes. A progressive age-dependent cytoskeletal pathology along with a reduction of lysosomal and, in minor extent, proteasomal activity could be

  2. SkyProbeBV: dual-color absolute sky transparency monitor to optimize science operations

    Science.gov (United States)

    Cuillandre, Jean-Charles; Magnier, Eugene; Sabin, Dan; Mahoney, Billy

    2008-07-01

    Mauna Kea (4200 m elevation, Hawaii) is known for its pristine seeing conditions, but sky transparency can be an issue for science operations: 25% of the nights are not photometric, a cloud coverage mostly due to high-altitude thin cirrus. The Canada-France-Hawaii Telescope (CFHT) is upgrading its real-time sky transparency monitor in the optical domain (V-band) into a dual-color system by adding a B-band channel and redesigning the entire optical and mechanical assembly. Since 2000, the original single-channel SkyProbe has gathered one exposure every minute during each observing night using a small CCD camera with a very wide field of view (35 sq. deg.) encompassing the region pointed by the telescope for science operations, and exposures long enough (30 seconds) to capture at least 100 stars of Hipparcos' Tychos catalog at high galactic latitudes (and up to 600 stars at low galactic latitudes). A key advantage of SkyProbe over direct thermal infrared imaging detection of clouds, is that it allows an accurate absolute measurement, within 5%, of the true atmospheric absorption by clouds affecting the data being gathered by the telescope's main science instrument. This system has proven crucial for decision making in the CFHT queued service observing (QSO), representing today 95% of the telescope time: science exposures taken in non-photometric conditions are automatically registered for being re-observed later on (at 1/10th of the original exposure time per pointing in the observed filters) to ensure a proper final absolute photometric calibration. If the absorption is too high, exposures can be repeated, or the observing can be done for a lower ranked science program. The new dual color system (simultaneous B & V bands) will allow a better characterization of the sky properties above Mauna Kea and should enable a better detection of the thinner cirrus (absorption down to 0.02 mag., i.e. 2%). SkyProbe is operated within the Elixir pipeline, a collection of tools

  3. The Gamma-ray Sky with Fermi

    Science.gov (United States)

    Thompson, David

    2012-01-01

    Gamma rays reveal extreme, nonthermal conditions in the Universe. The Fermi Gamma-ray Space Telescope has been exploring the gamma-ray sky for more than four years, enabling a search for powerful transients like gamma-ray bursts, novae, solar flares, and flaring active galactic nuclei, as well as long-term studies including pulsars, binary systems, supernova remnants, and searches for predicted sources of gamma rays such as dark matter annihilation. Some results include a stringent limit on Lorentz invariance derived from a gamma-ray burst, unexpected gamma-ray variability from the Crab Nebula, a huge gamma-ray structure associated with the center of our galaxy, surprising behavior from some gamma-ray binary systems, and a possible constraint on some WIMP models for dark matter.

  4. The all-sky 408 MHz survey

    International Nuclear Information System (INIS)

    Haslam, C.G.T.; Salter, C.J.; Stoffel, H.

    1981-01-01

    A brief outline of the results of this survey is presented. The 408 MHz All-sky Survey has been made from four radio continuum surveys observed between 1965 and 1978, using the Jodrell Bank MKI telescope (Haslam et al., 1970), the Effelsberg 100 metre telescope (Haslam et al., 1974) and the Parkes 64 metre telescope (Haslam et al., 1975). A detailed description of the survey data reduction and calibration methods, with preliminary astronomical results will soon be published (Haslam et al., 1980a) and a second paper will give an atlas of maps at the full survey resolution of 51' arc between half power points (Haslam et al., 1980b). A map, smoothed to a gaussian beam with resolution between half power poitns of 3 0 , is presented. (Auth.)

  5. Dark Skies, Bright Kids Year 8

    Science.gov (United States)

    Bittle, Lauren E.; Wenger, Trey; Johnson, Kelsey E.; Angell, Dylan; Burkhardt, Andrew; Davis, Blair; Firebaugh, Ariel; Hancock, Danielle; Richardson, Whitney; Rochford Hayes, Christian; Linden, Sean; Liss, Sandra; Matthews, Allison; McNair, Shunlante; Prager, Brian; Pryal, Matthew; Troup, Nicholas William

    2017-01-01

    We present activities from the eighth year of Dark Skies Bright Kids (DSBK), an entirely volunteer-run outreach organization based out of the Department of Astronomy at the University of Virginia. Our core mission is to enhance elementary science education and literacy in Central Virginia through fun, hands-on activities that introduce basic Astronomy concepts. Over the past seven years, our primary focus has been hosting an 8-10 week after-school astronomy club at underserved elementary and middle schools, and over the past several years, we have partnered with local businesses to host our Annual Central Virginia Star Party, a free event open to the community featuring star-gazing and planetarium shows. This past summer we expanded our reach through a new initiative to bring week-long summer day camps to south and southwest Virginia, home to some of the most underserved communities in the commonwealth.

  6. Dark Skies, Bright Kids Year 7

    Science.gov (United States)

    Bittle, Lauren E.; Johnson, Kelsey E.; Borish, H. Jacob; Burkhardt, Andrew; Firebaugh, Ariel; Hancock, Danielle; Rochford Hayes, Christian; Linden, Sean; Liss, Sandra; Matthews, Allison; Prager, Brian; Pryal, Matthew; Sokal, Kimberly R.; Troup, Nicholas William; Wenger, Trey

    2016-01-01

    We present updates from our seventh year of operation including new club content, continued assessments, and our fifth annual Star Party. Dark Skies, Bright Kids (DSBK) is an entirely volunteer-run outreach organization based out of the Department of Astronomy at the University of Virginia. Our core mission is to enhance elementary science education and literacy in Central Virginia through fun, hands-on activities that introduce basic Astronomy concepts. Our primary focus is hosting an 8-10 week after-school astronomy club at underserved elementary and middle schools. Each week, DSBK volunteers take the role of coaches to introduce astronomy-related concepts ranging from the Solar System to galaxies to astrobiology, and to lead students in interactive learning activities. Another hallmark of DSBK is hosting our Annual Central Virginia Star Party, a free event open to the community featuring star-gazing and planetarium shows.

  7. 76 FR 42704 - Sky River LLC; Notice of Filing

    Science.gov (United States)

    2011-07-19

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket Nos. ER11-3277-000; ER11-3277-001] Sky River LLC; Notice of Filing Take notice that, on July 8, 2011, Sky River LLC filed to amend its Open Access Transmission Tariff (OATT) filing, submitted on April 1, 2011 and amended on April 7...

  8. Gender Roles and Night-Sky Watching among College Students

    Science.gov (United States)

    Kelly, William E.; McGee, Catherine M.

    2012-01-01

    The present study investigated the relationship between gender roles and night-sky watching in a sample of college students (N=161). The Bem Sex-Role Inventory (BSRI) and the Noctcaelador Inventory (NI) were used to investigate the differences between gender role groups for night-sky watching. The results supported the hypothesis that androgynous…

  9. Daylight and energy implications for CIE standard skies

    International Nuclear Information System (INIS)

    Li, Danny H.W.

    2007-01-01

    Recently, the International Commission on Illumination (CIE) has adopted a range of 15 standard skies, which include the existing CIE overcast, very clear and cloudless polluted skies, covering the whole probable spectrum of usual skies found in the world. The traditional daylight factor (DF) approach with the calculations being based on an isotropic overcast sky, however, cannot cater to the dynamic variations in daylight luminance and illuminance as the sun's position changes under non-overcast skies. Currently, we propose a numerical procedure that considers the changes in the luminance of sky elements to predict the interior daylight illuminance under the 15 CIE standard skies. This paper evaluates the method by using a typical room with a large vertical glazing window facing north. The available daylight for the room at mean hourly sun positions in each month in terms of DF and illuminance levels were determined and compared with those based on a computer program, namely, RADIANCE. A modification to the ground reflected component was made when a well defined shadow was cast in front of the window facade. It is shown that the results estimated by the proposed approach are in reasonably good agreement with those produced from RADIANCE. The interior daylight and lighting energy consumption were also determined using the proposed and the traditional DF approaches. The findings reveal that daylighting designs using existing CIE overcast sky only would considerably underestimate the indoor daylight availability and electric lighting energy savings, especially under high design indoor illuminance settings

  10. Region of Nova Cygni 1975 on the Palomar Sky Survey

    International Nuclear Information System (INIS)

    Beardsley, W.R.; King, M.W.; Russell, J.L.; Stein, J.W.

    1975-01-01

    Careful superposition of a blue Palomar Sky Survey print onto a sectored photograph of Nova Cygni 1975 obtained with the Thaw 30-inch (76-cm) refractor at the Allegheny Observatory decisively confirms the fact that no star brighter than magnitude 21 appears on the Sky Survey print at that position

  11. The New Progress of the Starry Sky Project of China

    Science.gov (United States)

    Wang, Xiaohua

    2015-08-01

    Since the 28th General Assembly of IAU, the SSPC team made new progress:1. Enhanced the function of the SSPC team-- Established the contact with IAU C50, IUCN Dark Skies Advisory Group, AWB and IDA,and undertakes the work of the IDA Beijing Chapter.-- Got supports from China’s National Astronomical Observatories, Beijing Planetarium, and Shanghai Science and Technology Museum.-- Signed cooperation agreements with Lighting Research Center, English Education Group and law Firm; formed the team force.2. Put forward a proposal to national top institutionThe SSPC submitted the first proposal about dark sky protection to the Chinese People’s Political Consultative Conference.3. Introduced the Criteria and Guideline of dark sky protectionThe SSPC team translated 8 documents of IDA, and provided a reference basis for Chinese dark sky protection.4. Actively establish dark sky places-- Plan a Dark Sky Reserve around Ali astronomical observatory (5,100m elevation) in Tibet. China’s Xinhua News Agency released the news.-- Combining with Hangcuo Lake, a National Natural Reserve and Scenic in Tibet, to plan and establish the Dark Sky Park.-- Cooperated with Shandong Longgang Tourism Group to construct the Dream Sky Theme Park in the suburbs of Jinan city.In the IYL 2015, the SSPC is getting further development:First, make dark sky protection enter National Ecological Strategy of “Beautiful China”. We call on: “Beautiful China” needs “Beautiful Night Sky” China should care the shared starry sky, and left this resource and heritage for children.Second, hold “Cosmic Light” exhibition in Shanghai Science and Technology Museum on August.Third, continue to establish Dark Sky Reserve, Park and Theme Park. We want to make these places become the bases of dark sky protection, astronomical education and ecological tourism, and develop into new cultural industry.Fourth, actively join international cooperation.Now, “Blue Sky, White Cloud and Starry Sky “have become

  12. Gaia , an all sky astrometric and photometric survey

    International Nuclear Information System (INIS)

    Carrasco, J.M.

    2017-01-01

    Gaia space mission includes a low resolution spectroscopic instrument to classify and parametrize the observed sources. Gaia is a full-sky unbiased survey down to about 20th magnitude. The scanning law yields a rather uniform coverage of the sky over the full mission. The data reduction is a global one over the full mission. Both sky coverage and data reduction strategy ensure an unprecedented all-sky homogeneous spectrophotometric survey. Certainly, that survey is of interest for future on-ground and space projects (LSST, PLATO, EUCLID, ...). This work addresses the exploitation of the Gaia spectrophotometry as standard photometry reference through the discussion of the sky coverage, the spectrophotometric precision and the expected uncertainties of the synthetic photometry derived from the low resolution Gaia spectra and photometry.

  13. Reconstruction of Sky Illumination Domes from Ground-Based Panoramas

    Science.gov (United States)

    Coubard, F.; Lelégard, L.; Brédif, M.; Paparoditis, N.; Briottet, X.

    2012-07-01

    The knowledge of the sky illumination is important for radiometric corrections and for computer graphics applications such as relighting or augmented reality. We propose an approach to compute environment maps, representing the sky radiance, from a set of ground-based images acquired by a panoramic acquisition system, for instance a mobile-mapping system. These images can be affected by important radiometric artifacts, such as bloom or overexposure. A Perez radiance model is estimated with the blue sky pixels of the images, and used to compute additive corrections in order to reduce these radiometric artifacts. The sky pixels are then aggregated in an environment map, which still suffers from discontinuities on stitching edges. The influence of the quality of estimated sky radiance on the simulated light signal is measured quantitatively on a simple synthetic urban scene; in our case, the maximal error for the total sensor radiance is about 10%.

  14. RECONSTRUCTION OF SKY ILLUMINATION DOMES FROM GROUND-BASED PANORAMAS

    Directory of Open Access Journals (Sweden)

    F. Coubard

    2012-07-01

    Full Text Available The knowledge of the sky illumination is important for radiometric corrections and for computer graphics applications such as relighting or augmented reality. We propose an approach to compute environment maps, representing the sky radiance, from a set of ground-based images acquired by a panoramic acquisition system, for instance a mobile-mapping system. These images can be affected by important radiometric artifacts, such as bloom or overexposure. A Perez radiance model is estimated with the blue sky pixels of the images, and used to compute additive corrections in order to reduce these radiometric artifacts. The sky pixels are then aggregated in an environment map, which still suffers from discontinuities on stitching edges. The influence of the quality of estimated sky radiance on the simulated light signal is measured quantitatively on a simple synthetic urban scene; in our case, the maximal error for the total sensor radiance is about 10%.

  15. Day/night whole sky imagers for 24-h cloud and sky assessment: history and overview.

    Science.gov (United States)

    Shields, Janet E; Karr, Monette E; Johnson, Richard W; Burden, Art R

    2013-03-10

    A family of fully automated digital whole sky imagers (WSIs) has been developed at the Marine Physical Laboratory over many years, for a variety of research and military applications. The most advanced of these, the day/night whole sky imagers (D/N WSIs), acquire digital imagery of the full sky down to the horizon under all conditions from full sunlight to starlight. Cloud algorithms process the imagery to automatically detect the locations of cloud for both day and night. The instruments can provide absolute radiance distribution over the full radiance range from starlight through daylight. The WSIs were fielded in 1984, followed by the D/N WSIs in 1992. These many years of experience and development have resulted in very capable instruments and algorithms that remain unique. This article discusses the history of the development of the D/N WSIs, system design, algorithms, and data products. The paper cites many reports with more detailed technical documentation. Further details of calibration, day and night algorithms, and cloud free line-of-sight results will be discussed in future articles.

  16. Stability of the nine sky quality meters in the Dutch night sky brightness monitoring network.

    Science.gov (United States)

    den Outer, Peter; Lolkema, Dorien; Haaima, Marty; van der Hoff, Rene; Spoelstra, Henk; Schmidt, Wim

    2015-04-22

    In the context of monitoring abundance of artificial light at night, the year-to-year stability of Sky Quality Meters (SQMs) is investigated by analysing intercalibrations derived from two measurement campaigns that were held in 2011 and 2012. An intercalibration comprises a light sensitivity factor and an offset for each SQM. The campaigns were concerned with monitoring measurements, each lasting one month. Nine SQMs, together forming the Night Sky Brightness Monitoring network (MHN) in The Netherlands, were involved in both campaigns. The stability of the intercalibration of these instruments leads to a year-to-year uncertainty (standard deviation) of 5% in the measured median luminance occurring at the MHN monitoring locations. For the 10-percentiles and 90-percentiles, we find 8% and 4%, respectively. This means that, for urban and industrial areas, changes in the sky brightness larger than 5% become detectable. Rural and nature areas require an 8%-9% change of the median luminance to be detectable. The light sensitivety agrees within 8% for the whole group of SQMs.

  17. The Python Sky Model: software for simulating the Galactic microwave sky

    Science.gov (United States)

    Thorne, B.; Dunkley, J.; Alonso, D.; Næss, S.

    2017-08-01

    We present a numerical code to simulate maps of Galactic emission in intensity and polarization at microwave frequencies, aiding in the design of cosmic microwave background experiments. This python code builds on existing efforts to simulate the sky by providing an easy-to-use interface and is based on publicly available data from the WMAP (Wilkinson Microwave Anisotropy Probe) and Planck satellite missions. We simulate synchrotron, thermal dust, free-free and anomalous microwave emission over the whole sky, in addition to the cosmic microwave background, and include a set of alternative prescriptions for the frequency dependence of each component, for example, polarized dust with multiple temperatures and a decorrelation of the signals with frequency, which introduce complexity that is consistent with current data. We also present a new prescription for adding small-scale realizations of these components at resolutions greater than current all-sky measurements. The usefulness of the code is demonstrated by forecasting the impact of varying foreground complexity on the recovered tensor-to-scalar ratio for the LiteBIRD satellite. The code is available at: https://github.com/bthorne93/PySM_public.

  18. Sky Mining - Application to Photomorphic Redshift Estimation

    Science.gov (United States)

    Nayak, Pragyansmita

    The field of astronomy has evolved from the ancient craft of observing the sky. In it's present form, astronomers explore the cosmos not just by observing through the tiny visible window used by our eyes, but also by exploiting the electromagnetic spectrum from radio waves to gamma rays. The domain is undoubtedly at the forefront of data-driven science. The data growth rate is expected to be around 50%--100% per year. This data explosion is attributed largely to the large-scale wide and deep surveys of the different regions of the sky at multiple wavelengths (both ground and space-based surveys). This dissertation describes the application of machine learning methods to the estimation of galaxy redshifts leveraging such a survey data. Galaxy is a large system of stars held together by mutual gravitation and isolated from similar systems by vast regions of space. Our view of the universe is closely tied to our understanding of galaxy formation. Thus, a better understanding of the relative location of the multitudes of galaxies is crucial. The position of each galaxy can be characterized using three coordinates. Right Ascension (ra) and Declination (dec) are the two coordinates that locate the galaxy in two dimensions on the plane of the sky. It is relatively straightforward to measure them. In contrast, fixing the third coordinate that is the galaxy's distance from the observer along the line of sight (redshift 'z') is considerably more challenging. "Spectroscopic redshift" method gives us accurate and precise measurements of z. However, it is extremely time-intensive and unusable for faint objects. Additionally, the rate at which objects are being identified via photometric surveys far exceeds the rate at which the spectroscopic redshift measurements can keep pace in determining their distance. As the surveys go deeper into the sky, the proportion of faint objects being identified also continues to increase. In order to tackle both these drawbacks increasing in

  19. Promoting Dark Sky Protection in Chile: the Gabriel Mistral IDA Dark Sky Sanctuary and Other AURA Initiatives

    Science.gov (United States)

    Smith, R. Chris; Smith, Malcolm; Pompea, Stephen; Sanhueza, Pedro; AURA-Chile EPO Team

    2018-01-01

    For over 20 years, AURA has been leading efforts promoting the protection of dark skies in northern Chile. Efforts began in the early 1990s at AURA's Cerro Tololo Inter-American Observatory (CTIO), working in collaboration with other international observatories in Chile including Las Campanas Observatory (LCO) and the European Southern Observatory (ESO). CTIO also partnered with local communities, for example supporting Vicuña's effort to establish the first municipal observatory in Chile. Today we have developed a multifaceted effort of dark sky protection, including proactive government relations at national and local levels, a strong educational and public outreach program, and a program of highlighting international recognition of the dark skies through the IDA Dark Sky Places program. Work on international recognition has included the declaration of the Gabriel Mistral IDA Dark Sky Sanctuary, the first such IDA sanctuary in the world.

  20. Maysin and Its Flavonoid Derivative from Centipedegrass Attenuates Amyloid Plaques by Inducting Humoral Immune Response with Th2 Skewed Cytokine Response in the Tg (APPswe, PS1dE9 Alzheimer's Mouse Model.

    Directory of Open Access Journals (Sweden)

    Yuno Song

    Full Text Available Alzheimer's disease (AD is a slow, progressive neurodegenerative disease and the most common type of dementia in the elderly. The etiology of AD and its underlying mechanism are still not clear. In a previous study, we found that an ethyl acetate extract of Centipedegrass (CG (i.e., EA-CG contained 4 types of Maysin derivatives, including Luteolin, Isoorientin, Rhamnosylisoorientin, and Derhamnosylmaysin, and showed protective effects against Amyloid beta (Aβ by inhibiting oligomeric Aβ in cellular and in vitro models. Here, we examined the preventative effects of EA-CG treatment on the Aβ burden in the Tg (Mo/Hu APPswe PS1dE9 AD mouse model. We have investigated the EA-CG efficacy as novel anti-AD likely preventing amyloid plaques using immunofluorescence staining to visually analyze Aβ40/42 and fibril formation with Thioflavin-S or 6E10 which are the profile of immunoreactivity against epitope Aβ1-16 or neuritic plaque, the quantitation of humoral immune response against Aβ, and the inflammatory cytokine responses (Th1 and Th2 using ELISA and QRT-PCR. To minimize the toxicity of the extracted CG, we addressed the liver toxicity in response to the CG extract treatment in Tg mice using relevant markers, such as aspartate aminotransferase (AST/ alanine aminotransferase (ALT measurements in serum. The EA-CG extract significantly reduced the Aβ burden, the concentration of soluble Aβ40/42 protein, and fibril formation in the hippocampus and cortex of the Tg mice treated with EA-CG (50 mg/kg BW/day for 6 months compared with the Tg mice treated with a normal diet. Additionally, the profile of anti-inflammatory cytokines revealed that the levels of Th2 (interleukin-4 (IL-4 and interleukin-10 (IL-10 cytokines are more significantly increased than Th1 (interferon-γ (IFN-γ, interleukin-2(IL-2 in the sera. These results suggest that the EA-CG fraction induces IL-4/IL-10-dependent anti-inflammatory cytokines (Th2 rather than pro

  1. Pi of the Sky Telescopes in Spain and Chile

    Directory of Open Access Journals (Sweden)

    M. Siudek

    2011-01-01

    Full Text Available Pi of the Sky is a system of robotic telescopes designed for observations of short timescale astrophysical phenomena, e.g. prompt optical GRB emissions. The apparatus is designed to monitor a large fraction of the sky with 12–13 m range and time resolution of the order of 1–10 seconds. In October 2010 the first unit of the new Pi of the Sky detector system was successfully installed in the INTA El Arenosillo Test Centre in Spain. We also moved our prototype detector from Las Campanas Observatory to San Pedro de Atacama Observatory in March 2011. The status and performance of both detectors is presented.

  2. Sky luminosity for Rio de Janeiro City - Brazil

    International Nuclear Information System (INIS)

    Corbella, O.D.

    1995-12-01

    This paper presents sky luminosity data for Rio de Janeiro City, useful to be used in daylighting design in architecture. The data are presented as monthly graphics that correlate sunshine-hours with the frequency of occurrence during the day of a specific type of sky, that would present one of five defined characteristics (among clear and overcast sky). These results were derived from the knowledge of daily solar radiation and sunshine-hours data, for every day for a twelve year period. (author). 10 refs, 13 figs, 16 tabs

  3. SNAP sky background at the north ecliptic pole

    International Nuclear Information System (INIS)

    Aldering, Greg

    2002-01-01

    I summarize the extant direct and indirect data on the sky background SNAP will see at the North Ecliptic Pole over the wavelength range 0.4 < λ < 1.7 (micro)m. At the spatial resolution of SNAP the sky background due to stars and galaxies is resolved, so the only source considered is zodiacal light. Several models are explored to provide interpolation in wavelength between the broadband data from HST and COBE observations. I believe the input data are now established well enough that the accuracy of the sky background presented here is sufficient for SNAP simulations, and that it will stand up to scrutiny by reviewers

  4. The night sky brightness at McDonald Observatory

    Science.gov (United States)

    Kalinowski, J. K.; Roosen, R. G.; Brandt, J. C.

    1975-01-01

    Baseline observations of the night sky brightness in B and V are presented for McDonald Observatory. In agreement with earlier work by Elvey and Rudnick (1937) and Elvey (1943), significant night-to-night and same-night variations in sky brightness are found. Possible causes for these variations are discussed. The largest variation in sky brightness found during a single night is approximately a factor of two, a value which corresponds to a factor-of-four variation in airglow brightness. The data are used to comment on the accuracy of previously published surface photometry of M 81.

  5. The Monthly Sky Guide: Sixth Edition

    Science.gov (United States)

    Ridpath, Ian; Tirion, Wil

    2003-06-01

    The latest edition of Ian Ridpath and Wil Tirion's popular guide to the night sky is updated for planet positions and forthcoming eclipses up to the end of the year 2007. With one chapter for each month of the year, this is an easy-to-use handbook for anyone wanting to identify constellations, star clusters, nebulae, to plot the movement of planets, or witness solar and lunar eclipses. Most of the features discussed are visible to the naked eye and all can be seen with a small telescope or binoculars. Ian Ridpath has been a full-time writer, broadcaster and lecturer on astronomy and space for more than twenty-five years. He has written and edited more than 40 books, including A Comet Called Haley (Cambridge, 1985). Wil Tirion made his first star map in 1977. It showed stars to the magnitude of 6.5 and was issued as a set of maps by the British Astronomical Association in 1981. He has illustrated numerous books and magazines, including The Cambridge Star Atlas (Cambridge, 2001). Previous Edition Pb (1999): 0-521-66771-2

  6. Hermite scatterers in an ultraviolet sky

    Science.gov (United States)

    Parker, Kevin J.

    2017-12-01

    The scattering from spherical inhomogeneities has been a major historical topic in acoustics, optics, and electromagnetics and the phenomenon shapes our perception of the world including the blue sky. The long wavelength limit of ;Rayleigh scattering; is characterized by intensity proportional to k4 (or λ-4) where k is the wavenumber and λ is the wavelength. With the advance of nanotechnology, it is possible to produce scatterers that are inhomogeneous with material properties that are functions of radius r, such as concentric shells. We demonstrate that with proper choice of material properties linked to the Hermite polynomials in r, scatterers can have long wavelength scattering behavior of higher powers: k8, k16, and higher. These ;Hermite scatterers; could be useful in providing unique signatures (or colors) to regions where they are present. If suspended in air under white light, the back-scattered spectrum would be shifted from blue towards violet and then ultraviolet as the higher order Hermite scatterers were illuminated.

  7. Dark Skies, Bright Kids Year 9

    Science.gov (United States)

    Burkhardt, Andrew Michael; Matthews, Allison M.; Johnson, Kelsey E.; Avilez, Ian; Beale, Luca; Bittle, Lauren E.; Bordenave, David; Finn, Molly; Firebaugh, Ariel; Hancock, Danielle; Hughes, Paul; Rochford Hayes, Christian; Lewis, Hannah; Linden, Sean; Liss, Sandra; Liu, Mengyao; McNair, Shunlante; Murphy, Edward; Prager, Brian; Pryal, Matthew; Richardson, Whitney; Song, Yiqing; Troup, Nicholas; Villadsen, Jackie; Wenger, Trey V.; Wilson, Robert Forrest

    2018-01-01

    We present updates from the ninth year of operation of Dark Skies, Bright Kids (DSBK) including new club content, continued assessments, and our seventh annual Star Party. DSBK is an entirely volunteer-run outreach organization based out of the Department of Astronomy at the University of Virginia. Our core mission is to enhance elementary science education and literacy in Virginia through fun, hands-on activities that introduce basic Astronomy concepts. DSBK’s most fundamental program is an 8-10 week long after-school Astronomy camp at surrounding local elementary schools, where each week introduces new concepts through interactive hands-on activities. Over the past two summers, we have traveled to four rural Virginia locations to bring week-long Astronomy camps to otherwise overlooked elementary school districts. These programs aim to inspire a curiosity for science and include inquiry based activities in topics ranging from the electromagnetic spectrum to the classification and evolution of galaxies. We strive to be self-reflective in our mission to inspire scientific curiosity in the minds of underserved demographics. In this effort, we continually assess the effectiveness of each activity through feedback in student-kept journal pages and observed excitement levels. This self-reflection has initiated the development of new curriculum. In addition, differing from our normal collaboration with local elementary schools, we have found great success partnering with local youth organizations, who may better represent DSBK's target demographics and have infrastructure to support incoming outreach groups.

  8. Blue Sky Birds Come to the World

    Directory of Open Access Journals (Sweden)

    Bura Sabiha Kelek

    2015-06-01

    Full Text Available The New Supply System comes to all fields for logistics.Drone is an unmanned vehicle for loading and unloading packages.Perhaps we can imagine it as a ‘’blue sky bird’’. This new trend has three important impacts that are determined by technoligical capabilities, ,regularity pressure, and public acceptance so that it will be dealed within current powers and circumstances. This kind of vehicles are used in different capacities, such as multicopter,drone or robot.Logistics’ issues are interested in short-term delivery systems for customer satisfaction but all developments go through GPS so it is based on 21st century technological developments, which have been tested on a short-term basis and will be expected to be of use in 2 years. The purpose of this research is to give lead to researchers information about risk and the advantages of using the technology in this manner.Some advantages and disadvantages ,schedules’ problems in the system will be identifed.

  9. Vanilla Sky – El cuento del narcisista

    Directory of Open Access Journals (Sweden)

    Graham St. John STOTT

    2016-09-01

    Full Text Available Vanilla Sky (2001, de Cameron Crowe, normalmente se aprecia como un juego intelectual; no obstante, su temática es mucho más oscura que lo que dicha etiqueta podría sugerir. Mientras recorre las diferentes fases del sueño de David Aames (un sueño en el que se mueve de una pretensión de amor a una de homicidio, nos damos cuenta de que David padece un trastorno de la autoestima. Utilizando como referencia Atracción Fatal (1987, de Adrian Lyne, para demostrar la incapacidad de tener en cuenta las necesidades de otros, la película de Crowe nos muestra un caso práctico de trastorno narcisista de la personalidad. David mata porque no es capaz de aceptar las exigencias de otros, ya que supondría para él ponerse en una condición inferior a la autosuficiencia. No resulta sorprendente, por lo tanto, su horror cuando al final de la película se despierta y descubre que su amante sigue viva.

  10. Surprise Ultraviolet Party in the Sky

    Science.gov (United States)

    2005-01-01

    Galaxies aren't the only objects filling up the view of NASA's Galaxy Evolution Explorer. Since its launch in 2003, the space telescope -- originally designed to observe galaxies across the universe in ultraviolet light -- has discovered a festive sky blinking with flaring and erupting stars, as well as streaking asteroids, satellites and space debris. A group of six streaking objects -- the identities of which remain unknown -- can be seen here flying across the telescope's sight in this sped-up movie. The two brightest objects appear to perform a sharp turn then travel in the reverse direction. This illusion is most likely the result of the Galaxy Evolution Explorer overtaking the objects as it orbits around Earth. Careful inspection reveals four additional faint objects with the same timing and behavior. These faint objects are easiest to see during the retrograde portion of their paths. Three appear between the two bright sources, and one is above them, near the edge of the field of view. These bonus objects are being collected in to public catalogues for other astronomers to study.

  11. Lighting up the sky for CERN's anniversary

    CERN Document Server

    2004-01-01

    For CERN's Golden Jubilee, the Canton of Geneva, supported by the Pays de Gex local authorities, lit up eight points around the LHC ring. On the date of CERN's fiftieth anniversary, 29 September 2004, the Organization's Host State authorities gave the Laboratory a gift of light. As night fell, twenty-four powerful floodlights blazed into the night sky from the eight access points to the future LHC. For the many spectators gathered at a special vantage point above the village of Crozet, these beams emanating from the valley floor marked out the locations of the access shafts around the 27-km of the LHC tunnel.The event was organised by the Department of Justice, Police and Security of the Canton of Geneva, with the participation of the Crozet local council and support of local councils in the Canton of Geneva, the Communauté des communes of the Pays de Gex, and the Ain Préfecture. This joint gift from the local authorities on both sides of the French-Swiss border has great symbolic value for an organisatio...

  12. Dark Skies, Bright Kids Year 6

    Science.gov (United States)

    Liss, Sandra; Troup, Nicholas William; Johnson, Kelsey E.; Barcos-Munoz, Loreto D.; Beaton, Rachael; Bittle, Lauren; Borish, Henry J.; Burkhardt, Andrew; Corby, Joanna; Dean, Janice; Hancock, Danielle; King, Jennie; Prager, Brian; Romero, Charles; Sokal, Kimberly R.; Stierwalt, Sabrina; Wenger, Trey; Zucker, Catherine

    2015-01-01

    Now entering our sixth year of operation, Dark Skies, Bright Kids (DSBK) is an entirely volunteer-run outreach organization based out of the Department of Astronomy at the University of Virginia. Our core mission is to enhance elementary science education and literacy in central Virginia through fun, hands-on activities that introduce basic Astronomy concepts beyond Virginia's Standards of Learning. Our primary focus is hosting an 8-10 week after-school astronomy club at underserved elementary and middle schools. Each week, DSBK volunteers take the role of coaches to introduce astronomy-related concepts ranging from the Solar System to galaxies to astrobiology, and to lead students in interactive learning activities. Another hallmark of DSBK is hosting our Annual Central Virginia Star Party, a free event open to the community featuring star-gazing and planetarium shows.DSBK has amassed over 15,000 contact hours since 2009 and we continue to broaden our impact. One important step we have taken in the past year is to establish a graduate student led assessment program to identify and implement directed learning goals for DSBK outreach. The collection of student workbooks, observations, and volunteer surveys indicates broad scale success for the program both in terms of student learning and their perception of science. The data also reveal opportunities to improve our organizational and educational practices to maximize student achievement and overall volunteer satisfaction for DSBK's future clubs and outreach endeavors.

  13. A WLED based on LuAG:Ce3+ PiG coated red-emitting K2SiF6:Mn4+ phosphor by screen-printing

    Science.gov (United States)

    Cao, Rui; Wu, Lingchao; Di, Xiaoxuan; Li, Pengzhi; Hu, Guangcai; Liang, Xiaojuan; Xiang, Weidong

    2017-08-01

    It is high-profile that the use of phosphor-in-glass (PiG) is extensive because of its excellent advantages in thermal resistance and lifetime aspects, and so on. Here, white light-emitting diodes (WLED) based on LuAG:Ce3+ PiG coated red-emitting K2SiF6:Mn4+ (KSF) phosphors by screen-printing are fabricated. Among all of these, the commercial LuAG phosphors and glass raw materials of TeO2-based glass, were weighted and milled in an agate thoroughly. Then, the mixture was melted and sintered at 850 K or so for 20 min in the ambient atmosphere through low temperature co-fired method, cold-forming LuAG PiG clump and cut into different LuAG PiG thicknesses. After that, the commercial red phosphor KSF was coated on LuAG PiG by screen-printing technique. Finally, high-performance WLEDs based on the TeO2-based glass were obtained, tested and characterized, which exhibit a highest color rendering index of 94.1, a lowest color temperature of 3744 K and a largest luminous efficiency of 101.02 lm·W-1. Most noticeably of all, the promising method has excellent developing potential for industrialization in high-power WLED.

  14. The Pan-STARRS Survey for Transients (PSST)

    Science.gov (United States)

    Huber, Mark; Carter Chambers, Kenneth; Flewelling, Heather; Smartt, Stephen J.; Smith, Ken; Wright, Darryl

    2015-08-01

    The Pan-STARRS1 (PS1) Science Consortium finished the 3Pi survey of the whole sky north of -30 degrees between 2010-2014 in grizy (PS1 specific filters) and the PS1 telescope has been running a wide-field survey for near earth objects, funded by NASA through the NEO Observation Program. This survey takes data in a w-band (wide-band filter spanning g,r,i) in dark time, and combinations of r, i, z and y during bright time. We are now processing these data through the Pan-STARRS IPP difference imaging pipeline and recovering stationary transients. Effectively the 3Pi survey for transients that started during the PS1 Science Consortium is being continued under the new NEO optimized operations mode. The observing procedure in this case is to take a quad of exposures, typically 30-45 seconds separated by 10-20 minutes each, typically revealing high confidence transients (greater than 5-sigma) to depths of i~ 20.7, y~18.3 (AB mags). This cadence may be repeated on subsequent nights in a return pointing.Continuing the public release of the first 880 transients from the PS1 3Pi survey during the search period September 2013 - January 2014, beginning February 2015, the transient events using the data from the the Pan-STARRS NEO Science Consortium are now regularly added. These are mostly supernova candidates, but the list also contains some variable stars, AGN, and nuclear transients. The light curves are too sparsely sampled to be of standalone use, but they may be of use to the community in combining with existing data (e.g. Fraser et al. 2013, ApJ, 779, L8), constraining explosion and rise times (e.g. Nicholl et al. 2013, Nature, 502, 346) as well as many being new discoveries.For additional details visit http://star.pst.qub.ac.uk/ps1threepi/

  15. Tropospheric haze and colors of the clear twilight sky.

    Science.gov (United States)

    Lee, Raymond L; Mollner, Duncan C

    2017-07-01

    At the earth's surface, clear-sky colors during civil twilights depend on the combined spectral effects of molecular scattering, extinction by tropospheric aerosols, and absorption by ozone. Molecular scattering alone cannot produce the most vivid twilight colors near the solar horizon, for which aerosol scattering and absorption are also required. However, less well known are haze aerosols' effects on twilight sky colors at larger scattering angles, including near the antisolar horizon. To analyze this range of colors, we compare 3D Monte Carlo simulations of skylight spectra with hyperspectral measurements of clear twilight skies over a wide range of aerosol optical depths. Our combined measurements and simulations indicate that (a) the purest antisolar twilight colors would occur in a purely molecular, multiple-scattering atmosphere, whereas (b) the most vivid solar-sky colors require at least some turbidity. Taken together, these results suggest that multiple scattering plays an important role in determining the redness of the antitwilight arch.

  16. (an)isotropy of the X-ray sky

    International Nuclear Information System (INIS)

    Shafer, R.A.; Fabian, A.C.

    1983-01-01

    An assessment is made of the extent to which the study of the isotropy of the X-ray sky has contributed to the present understanding of the structure of the universe at moderate redshifts. It is, of course, the anisotropic character of the sky flux that is valuable in this context. Although it is not currently possible to undertake measurements with the precision and small solid angles that are typically achieved in the microwave range, the comparatively crude limits from the X-ray fluctuations place limits on the largest scale structure of the universe. After indicating the nature of measurements made, with the HEAO 1 A-2 experiment, of the X-ray sky and its anisotropies, it is shown how these place limits on the origin of the X-ray sky and on any large scale structure of the universe. 40 references

  17. Tropical rainforest response to marine sky brightening climate engineering

    Science.gov (United States)

    Muri, Helene; Niemeier, Ulrike; Kristjánsson, Jón Egill

    2015-04-01

    Tropical forests represent a major atmospheric carbon dioxide sink. Here the gross primary productivity (GPP) response of tropical rainforests to climate engineering via marine sky brightening under a future scenario is investigated in three Earth system models. The model response is diverse, and in two of the three models, the tropical GPP shows a decrease from the marine sky brightening climate engineering. Partial correlation analysis indicates precipitation to be important in one of those models, while precipitation and temperature are limiting factors in the other. One model experiences a reversal of its Amazon dieback under marine sky brightening. There, the strongest partial correlation of GPP is to temperature and incoming solar radiation at the surface. Carbon fertilization provides a higher future tropical rainforest GPP overall, both with and without climate engineering. Salt damage to plants and soils could be an important aspect of marine sky brightening.

  18. LOFAR and APERTIF Surveys of the Radio Sky: Probing Shocks ...

    Indian Academy of Sciences (India)

    LOFAR and APERTIF Surveys of the Radio Sky: Probing Shocks and Magnetic .... technology. This replaces the traditional and expensive mechanical dishes by a com- ... approach has been adopted (for details, see Röttgering et al. 2010).

  19. Using All-Sky Imaging to Improve Telescope Scheduling (Abstract)

    Science.gov (United States)

    Cole, G. M.

    2017-12-01

    (Abstract only) Automated scheduling makes it possible for a small telescope to observe a large number of targets in a single night. But when used in areas which have less-than-perfect sky conditions such automation can lead to large numbers of observations of clouds and haze. This paper describes the development of a "sky-aware" telescope automation system that integrates the data flow from an SBIG AllSky340c camera with an enhanced dispatch scheduler to make optimum use of the available observing conditions for two highly instrumented backyard telescopes. Using the minute-by-minute time series image stream and a self-maintained reference database, the software maintains a file of sky brightness, transparency, stability, and forecasted visibility at several hundred grid positions. The scheduling software uses this information in real time to exclude targets obscured by clouds and select the best observing task, taking into account the requirements and limits of each instrument.

  20. Post-Processing Resolution Enhancement of Open Skies Photographic Imagery

    National Research Council Canada - National Science Library

    Sperl, Daniel

    2000-01-01

    ...), which manages implementation of the Open Skies Treaty for the US Air Force, wants to determine if post-processing of the photographic images can improve spatial resolution beyond 30 cm, and if so...

  1. SKYMONITOR: A Global Network for Sky Brightness Measurements

    Science.gov (United States)

    Davis, Donald R.; Mckenna, D.; Pulvermacher, R.; Everett, M.

    2010-01-01

    We are implementing a global network to measure sky brightness at dark-sky critical sites with the goal of creating a multi-decade database. The heart of this project is the Night Sky Brightness Monitor (NSBM), an autonomous 2 channel photometer which measures night sky brightness in the visual wavelengths (Mckenna et al, AAS 2009). Sky brightness is measured every minute at two elevation angles typically zenith and 20 degrees to monitor brightness and transparency. The NSBM consists of two parts, a remote unit and a base station with an internet connection. Currently these devices use 2.4 Ghz transceivers with a range of 100 meters. The remote unit is battery powered with daytime recharging using a solar panel. Data received by the base unit is transmitted via email protocol to IDA offices in Tucson where it will be collected, archived and made available to the user community via a web interface. Two other versions of the NSBM are under development: one for radio sensitive areas using an optical fiber link and the second that reads data directly to a laptop for sites without internet access. NSBM units are currently undergoing field testing at two observatories. With support from the National Science Foundation, we will construct and install a total of 10 units at astronomical observatories. With additional funding, we will locate additional units at other sites such as National Parks, dark-sky preserves and other sites where dark sky preservation is crucial. We will present the current comparison with the National Park Service sky monitoring camera. We anticipate that the SKYMONITOR network will be functioning by the end of 2010.

  2. Sky Glow from Cities: The Army Illumination Model v2

    Science.gov (United States)

    2011-09-01

    corresponding to one 10th magnitude star per square degree and will not be pursued further here). Benn and Ellison find that the sky brightness at La Palma ...not have electricity, liquid and pressurized lamps are 23 included. For these latter two, liquid Citronella, lamp oil , liquid paraffin and...Properties; AFGL-TR-79-0214; Air Force Geophysics Laboratory: Hanscom Air Force Base, MA, 1979. 19. Benn, C. R. and Ellison, S. L. La Palma Night-Sky

  3. Dark Skies, Bright Kids! Year 3

    Science.gov (United States)

    Whelan, David G.; Johnson, K. E.; Barcos-Munoz, L. D.; Beaton, R. L.; Borish, J.; Corby, J. F.; Dorsey, G.; Gugliucci, N. E.; Prager, B. J.; Ries, P. A.; Romero, C. E.; Sokal, K. R.; Tang, X.; Walker, L. M.; Yang, A. J.; Zasowski, G.

    2012-01-01

    Dark Skies, Bright Kids! (DSBK) is a program that brings astronomy education to elementary schools throughout central Virginia. In a relaxed, out-of-classroom atmosphere, we are able to foster the innate curiosity that young students have about science and the world around them. We target schools that are under-served due to their rural locale or special needs students, demonstrating that science is a fun and creative process to a segment of the population that might not otherwise be exposed to astronomy. Families are included in the learning experience during semi-annual `star parties'. Since last January, we have expanded the breadth and depth of our educational capabilities. We have developed new programs for use in our digital planetarium. We held the first Central Virginia Star Party, providing an atmosphere where local children from multiple schools were able to share their love for astronomy. Local government and University officials were also invited so that they could experience our focused science outreach. Most recently, we have become part of Ivy Creek School's Club Day activities, bringing our program to a new segment of the elementary school system in Albemarle County: those that have `low-incidence' disabilities, requiring special attention. We continue to develop a curriculum for after-school programs that functions as either a series of one-time activities or several months of focused outreach at one school. Many of these activities are provided on our website, http://www.astro.virginia.edu/dsbk/, for the wider astronomical community, including the new planetarium work. We have extended our book project to include two bilingual astronomy books called `Snapshots of the Universe,' one in Spanish and English, the other in French and English. These books introduce young people to some of the many wonders of the Universe through art and captions developed by DSBK volunteers.

  4. Dark Skies, Bright Kids! Year 4

    Science.gov (United States)

    Sokal, Kimberly R.; Johnson, K. E.; Barcos-Munoz, L. D.; Beaton, R.; Borish, J.; Crawford, S. B.; Corby, J.; Damke, G.; Dean, J.; Dorsey, G.; Jackson, L.; Liss, S.; Oza, A.; Peacock, S.; Prager, B.; Romero, C.; Sivakoff, G. R.; Walker, L.; Whelan, D. G.; Zucker, C.

    2013-01-01

    Aiming to engage young children's natural excitement and curiosity, the outreach group Dark Skies, Bright Kids (DSBK) brings a hands-on approach to astronomy to elementary schools in Virginia. We hope to enhance children's view and understanding of science while exploring the Universe using fun activities. DSBK focuses on rural and underserved schools in Albemarle County and offers a semester-long astronomy club for third through fifth grade students. We believe regular interactions foster personal relationships between students and volunteers that encourage a life-long interest in science. In our fourth year of hosting clubs, we returned to Ivy Creek Elementary School, where we saw wonderful responses from a special group of students with `low-incidence' disabilities. DSBK has grown to realize a broader reach beyond local astronomy clubs; we hope to ignite a spark of interest in astronomy and science more widely- in more children, their families, and their teachers. We also hosted the Second Annual Central Virginia Star Party with an open invitation to the community to encourage families to enjoy astronomy together. Throughout the year, DSBK now holds 'one-off' programs (akin to astronomy field days) for elementary schools and children's groups throughout Virginia. Furthermore, we are in the final stages of a project to create two bilingual astronomy books called "Snapshots of the Universe", in Spanish and French with English translations. This art book will be made available online and we are working to get a copy in every elementary school in the state. DSBK has begun to reach out to elementary school teachers in order to provide them with useful and engaging classroom material. We have adapted our volunteer-created activities into useful and ready-to-use lessons, available online. After improvements based on research through interactions and feedback from teachers, we have explicitly identified the learning goals in terms of Virginia's Standards of Learning

  5. Design of a device for sky light polarization measurements.

    Science.gov (United States)

    Wang, Yujie; Hu, Xiaoping; Lian, Junxiang; Zhang, Lilian; Xian, Zhiwen; Ma, Tao

    2014-08-14

    Sky polarization patterns can be used both as indicators of atmospheric turbidity and as a sun compass for navigation. The objective of this study is to improve the precision of sky light polarization measurements by optimal design of the device used. The central part of the system is composed of a Charge Coupled Device (CCD) camera; a fish-eye lens and a linear polarizer. Algorithms for estimating parameters of the polarized light based on three images are derived and the optimal alignments of the polarizer are analyzed. The least-squares estimation is introduced for sky light polarization pattern measurement. The polarization patterns of sky light are obtained using the designed system and they follow almost the same patterns of the single-scattering Rayleigh model. Deviations of polarization angles between observation and the theory are analyzed. The largest deviations occur near the sun and anti-sun directions. Ninety percent of the deviations are less than 5° and 40% percent of them are less than 1°. The deviations decrease evidently as the degree of polarization increases. It also shows that the polarization pattern of the cloudy sky is almost identical as in the blue sky.

  6. Predicting daylight illuminance on inclined surfaces using sky luminance data

    Energy Technology Data Exchange (ETDEWEB)

    Li, D.H.W.; Lau, C.C.S.; Lam, J.C. [City University of Hong Kong, Kowloon (China). Dept. of Building and Construction

    2005-07-01

    Daylight illuminance, particularly on vertical surfaces, plays a major role in determining and evaluating the daylighting performance of a building. In many parts of the world, however, the basic daylight illuminance data for various vertical planes are not always readily available. The usual method to obtain diffuse illuminance on tilted planes would be based on inclined surface models using data from the horizontal measurements. Alternatively, the diffuse illuminance on a sloping plane can be computed by integrating the luminance distribution of the sky 'seen' by the plane. This paper presents an approach to estimate the vertical outdoor illuminance from sky luminance data and solar geometry. Sky luminance data recorded from January 1999 to December 2001 in Hong Kong and generated by two well-known sky luminance models (Kittler and Perez) were used to compute the outdoor illuminance for the four principal vertical planes (N, E, S and W). The performance of this approach was evaluated against data measured in the same period. Statistical analysis indicated that using sky luminance distributions to predict outdoor illuminance can give reasonably good agreement with measured data for all vertical surfaces. The findings provide an accurate alternative to determine the amount of daylight on vertical as well as other inclined surfaces when sky luminance data are available. (author)

  7. Clear-Sky Narrowband Albedo Datasets Derived from Modis Data

    Science.gov (United States)

    Chen, Y.; Minnis, P.; Sun-Mack, S.; Arduini, R. F.; Hong, G.

    2013-12-01

    Satellite remote sensing of clouds requires an accurate estimate of the clear-sky radiances for a given scene to detect clouds and aerosols and to retrieve their microphysical properties. Knowing the spatial and angular variability of clear-sky albedo is essential for predicting the clear-sky radiance at solar wavelengths. The Clouds and the Earth's Radiant Energy System (CERES) Project uses the near-infrared (NIR; 1.24, 1.6 or 2.13 μm) and visible (VIS; 0.63 μm) channels available on the Terra and Aqua Moderate Resolution Imaging Spectroradiometers (MODIS) to help identify clouds and retrieve their properties. Generally, clear-sky albedo for a given surface type is determined for conditions when the vegetation is either thriving or dormant and free of snow. The clear-sky albedos are derived using a radiative transfer parameterization of the impact of the atmosphere, including aerosols, on the observed reflectances. This paper presents the method of generating monthly clear-sky overhead albedo maps for both snow-free and snow-covered surfaces of these channels using one year of MODIS (Moderate Resolution Imaging Spectroradiometer) CERES products. Maps of 1.24 and 1.6 μm are being used as the background to help retrieve cloud properties (e.g., effective particle size, optical depth) in CERES cloud retrievals in both snow-free and snow-covered conditions.

  8. Evaluation of Clear Sky Models for Satellite-Based Irradiance Estimates

    Energy Technology Data Exchange (ETDEWEB)

    Sengupta, Manajit [National Renewable Energy Lab. (NREL), Golden, CO (United States); Gotseff, Peter [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2013-12-01

    This report describes an intercomparison of three popular broadband clear sky solar irradiance model results with measured data, as well as satellite-based model clear sky results compared to measured clear sky data. The authors conclude that one of the popular clear sky models (the Bird clear sky model developed by Richard Bird and Roland Hulstrom) could serve as a more accurate replacement for current satellite-model clear sky estimations. Additionally, the analysis of the model results with respect to model input parameters indicates that rather than climatological, annual, or monthly mean input data, higher-time-resolution input parameters improve the general clear sky model performance.

  9. Spectral and Spatial UV Sky Radiance Measurements at a Seaside Resort Under Clear Sky and Slightly Overcast Conditions.

    Science.gov (United States)

    Sandmann, Henner; Stick, Carsten

    2014-01-01

    Spatial measurements of the diffusely scattered sky radiance at a seaside resort under clear sky and slightly overcast conditions have been used to calculate the sky radiance distribution across the upper hemisphere. The measurements were done in the summer season when solar UV radiation is highest. The selected wavelengths were 307, 350 and 550 nm representing the UVB, UVA and VIS band. Absolute values of radiance differ considerably between the wavelengths. Normalizing the measured values by use of direct solar radiance made the spatial distributions of unequal sky radiance comparable. The results convey a spatial impression of the different distributions of the radiance at the three wavelengths. Relative scattered radiance intensity is one order of magnitude greater in UVB than in VIS, whereas in UVA lies roughly in between. Under slightly overcast conditions scattered radiance is increased at all three wavelengths by about one order of magnitude. These measurements taken at the seaside underline the importance of diffuse scattered radiance. The effect of shading parts of the sky can be estimated from the distribution of sky radiance. This knowledge might be useful for sun seekers and in the treatment of people staying at the seaside for therapeutic purposes. © 2013 The American Society of Photobiology.

  10. First Observation of {tau}{r_arrow}3{pi}{eta}{nu}{sub {tau}} and {tau}{r_arrow} {ital f}{sub 1}{pi}{nu}{sub {tau}} Decays

    Energy Technology Data Exchange (ETDEWEB)

    Bergfeld, T.; Eisenstein, B.I.; Ernst, J.; Gladding, G.E.; Gollin, G.D.; Hans, R.M.; Johnson, E.; Karliner, I.; Marsh, M.A.; Palmer, M.; Selen, M.; Thaler, J.J. [University of Illinois, Champaign-Urbana, Illinois 61801 (United States); Edwards, K.W.; Edwards, K.W. [the Institute of Particle Physics, Montreal, Quebec (Canada); Bellerive, A.; Bellerive, A.; Janicek, R.; Janicek, R.; MacFarlane, D.B.; MacFarlane, D.B.; Patel, P.M.; Patel, P.M. [the Institute of Particle Physics, Montreal, Quebec (Canada); Sadoff, A.J. [Ithaca College, Ithaca, New York 14850 (United States); Ammar, R.; Baringer, P.; Bean, A.; Besson, D.; Coppage, D.; Darling, C.; Davis, R.; Hancock, N.; Kotov, S.; Kravchenko, I.; Kwak, N. [University of Kansas, Lawrence, Kansas 66045 (United States); Anderson, S.; Kubota, Y.; Lee, S.J.; ONeill, J.J.; Patton, S.; Poling, R.; Riehle, T.; Savinov, V.; Smith, A. [University of Minnesota, Minneapolis, Minnesota 55455 (United States); Alam, M.S.; Athar, S.B.; Ling, Z.; Mahmood, A.H.; Severini, H.; Timm, S.; Wappler, F. [State University of New York at Albany, Albany, New York 12222 (United States); Anastassov, A.; Blinov, S.; Duboscq, J.E.; Fujino, D.; Gan, K.K.; Hart, T.; Honscheid, K.; Kagan, H.; Kass, R.; Lee, J.; Spencer, M.B.; Sung, M.; Undrus, A.; Wanke, R.; Wolf, A.; Zoeller, M.M. [The Ohio State University, Columbus, Ohio 43210 (United States); Nemati, B.; Richichi, S.J.; Ross, W.R.; Skubic, P. [University of Oklahoma, Norman, Oklahoma 73019 (United States); Bishai, M.; Fast, J.; Gerndt, E.; Hinson, J.W.; Menon, N.; Miller, D.H.; Shibata, E.I.; Shipsey, I.P.; Yurko, M. [Purdue University, West Lafayette, Indiana 47907 (United States); Gibbons, L.; Glenn, S.; Johnson, S.D.; Kwon, Y.; Roberts, S.; Thorndike, E.H. [University of Rochester, Rochester, New York 14627 (United States); Jessop, C.P.; Lingel, K.; Marsiske, H.; Perl, M.L.; Ugolini, D.; Wang, R.; Zhou, X.; and others

    1997-09-01

    We have observed new channels for {tau} decays with an {eta} in the final state. We study 3-prong tau decays, using the {eta}{r_arrow}{gamma}{gamma} and {eta}{r_arrow}3{pi}{sup 0} decay modes and 1-prong decays with two {pi}{sup 0} {close_quote}s using the {eta}{r_arrow}{gamma}{gamma} channel. The measured branching fractions are B({tau}{sup {minus}}{r_arrow}{pi}{sup {minus}} {pi}{sup {minus}}{pi}{sup +}{eta}{nu}{sub {tau}})=(3.4{sup +0.6}{sub {minus}0.5} {plus_minus}0.6){times}10{sup {minus}4} and B({tau}{sup {minus}}{r_arrow}{pi}{sup {minus}} 2{pi}{sup 0}{eta}{nu}{sub {tau}}) =(1.4{plus_minus}0.6{plus_minus}0.3){times}10{sup {minus}4} . We observe clear evidence for f{sub 1}{r_arrow}{eta}{pi}{pi} substructure and measure B({tau}{sup {minus}}{r_arrow}f{sub 1}{pi}{sup {minus}}{nu}{sub {tau}})=(5.8{sup +1.4 }{sub {minus}1.3}{plus_minus}1.8){times}10{sup {minus}4} . We have also searched for {eta}{sup {prime}}(958) production and obtain 90{percent} C.L.upper limits B({tau}{sup {minus}}{r_arrow}{pi}{sup {minus}} {eta}{sup {prime}}{nu}{sub {tau}}){lt} 7.4{times}10{sup {minus}5} and B({tau}{sup {minus}}{r_arrow}{pi}{sup {minus}} {pi}{sup 0}{eta}{sup {prime}}{nu}{sub {tau} }){lt}8.0{times}10{sup {minus}5} . {copyright} {ital 1997} {ital The American Physical Society}

  11. NOAA AVHRR Clear-Sky Products over Oceans (ACSPO): Sea Surface Temperature, Clear Sky Radiances, and Aerosol Optical Depth for the Global Ocean, 2011 - present (NCEI Accession 0072979)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The AVHRR Clear-Sky Processor over Oceans, jointly developed between NESDIS STAR and OSDPD, produces AVHRR clear-sky products over oceans. ACSPO generates output...

  12. SkyNet: A Modular Nuclear Reaction Network Library

    Science.gov (United States)

    Lippuner, Jonas; Roberts, Luke F.

    2017-12-01

    Almost all of the elements heavier than hydrogen that are present in our solar system were produced by nuclear burning processes either in the early universe or at some point in the life cycle of stars. In all of these environments, there are dozens to thousands of nuclear species that interact with each other to produce successively heavier elements. In this paper, we present SkyNet, a new general-purpose nuclear reaction network that evolves the abundances of nuclear species under the influence of nuclear reactions. SkyNet can be used to compute the nucleosynthesis evolution in all astrophysical scenarios where nucleosynthesis occurs. SkyNet is free and open source, and aims to be easy to use and flexible. Any list of isotopes can be evolved, and SkyNet supports different types of nuclear reactions. SkyNet is modular so that new or existing physics, like nuclear reactions or equations of state, can easily be added or modified. Here, we present in detail the physics implemented in SkyNet with a focus on a self-consistent transition to and from nuclear statistical equilibrium to non-equilibrium nuclear burning, our implementation of electron screening, and coupling of the network to an equation of state. We also present comprehensive code tests and comparisons with existing nuclear reaction networks. We find that SkyNet agrees with published results and other codes to an accuracy of a few percent. Discrepancies, where they exist, can be traced to differences in the physics implementations.

  13. TWO MICRON ALL SKY SURVEY PHOTOMETRIC REDSHIFT CATALOG: A COMPREHENSIVE THREE-DIMENSIONAL CENSUS OF THE WHOLE SKY

    International Nuclear Information System (INIS)

    Bilicki, Maciej; Jarrett, Thomas H.; Cluver, Michelle E.; Steward, Louise; Peacock, John A.

    2014-01-01

    Key cosmological applications require the three-dimensional (3D) galaxy distribution on the entire celestial sphere. These include measuring the gravitational pull on the Local Group, estimating the large-scale bulk flow, and testing the Copernican principle. However, the largest all-sky redshift surveys—the 2MASS Redshift Survey and IRAS Point Source Catalog Redshift Survey—have median redshifts of only z = 0.03 and sample the very local universe. All-sky galaxy catalogs exist that reach much deeper—SuperCOSMOS in the optical, the Two Micron All Sky Survey (2MASS) in the near-IR, and WISE in the mid-IR—but these lack complete redshift information. At present, the only rapid way toward larger 3D catalogs covering the whole sky is through photometric redshift techniques. In this paper we present the 2MASS Photometric Redshift catalog (2MPZ) containing one million galaxies, constructed by cross-matching Two Micron All Sky Survey Extended Source Catalog (2MASS XSC), WISE, and SuperCOSMOS all-sky samples and employing the artificial neural network approach (the ANNz algorithm), trained on such redshift surveys as the Sloan Digital Sky Survey, 6dFGS, and 2dFGRS. The derived photometric redshifts have errors nearly independent of distance, with an all-sky accuracy of σ z = 0.015 and a very small percentage of outliers. In this way, we obtain redshift estimates with a typical precision of 12% for all the 2MASS XSC galaxies that lack spectroscopy. In addition, we have made an early effort toward probing the entire 3D sky beyond 2MASS, by pairing up WISE with SuperCOSMOS and training the ANNz on GAMA redshift data currently reaching to z med ∼ 0.2. This has yielded photo-z accuracies comparable to those in the 2MPZ. These all-sky photo-z catalogs, with a median z ∼ 0.1 for the 2MPZ, and significantly deeper for future WISE-based samples, will be the largest and most complete of their kind for the foreseeable future

  14. The BlueSky Smoke Modeling Framework: Recent Developments

    Science.gov (United States)

    Sullivan, D. C.; Larkin, N.; Raffuse, S. M.; Strand, T.; ONeill, S. M.; Leung, F. T.; Qu, J. J.; Hao, X.

    2012-12-01

    BlueSky systems—a set of decision support tools including SmartFire and the BlueSky Framework—aid public policy decision makers and scientific researchers in evaluating the air quality impacts of fires. Smoke and fire managers use BlueSky systems in decisions about prescribed burns and wildland firefighting. Air quality agencies use BlueSky systems to support decisions related to air quality regulations. We will discuss a range of recent improvements to the BlueSky systems, as well as examples of applications and future plans. BlueSky systems have the flexibility to accept basic fire information from virtually any source and can reconcile multiple information sources so that duplication of fire records is eliminated. BlueSky systems currently apply information from (1) the National Oceanic and Atmospheric Administration's (NOAA) Hazard Mapping System (HMS), which represents remotely sensed data from the Moderate Resolution Imaging Spectroradiometer (MODIS), Advanced Very High Resolution Radiometer (AVHRR), and Geostationary Operational Environmental Satellites (GOES); (2) the Monitoring Trends in Burn Severity (MTBS) interagency project, which derives fire perimeters from Landsat 30-meter burn scars; (3) the Geospatial Multi-Agency Coordination Group (GeoMAC), which produces helicopter-flown burn perimeters; and (4) ground-based fire reports, such as the ICS-209 reports managed by the National Wildfire Coordinating Group. Efforts are currently underway to streamline the use of additional ground-based systems, such as states' prescribed burn databases. BlueSky systems were recently modified to address known uncertainties in smoke modeling associated with (1) estimates of biomass consumption derived from sparse fuel moisture data, and (2) models of plume injection heights. Additional sources of remotely sensed data are being applied to address these issues as follows: - The National Aeronautics and Space Administration's (NASA) Tropical Rainfall Measuring Mission

  15. Mining the SDSS SkyServer SQL queries log

    Science.gov (United States)

    Hirota, Vitor M.; Santos, Rafael; Raddick, Jordan; Thakar, Ani

    2016-05-01

    SkyServer, the Internet portal for the Sloan Digital Sky Survey (SDSS) astronomic catalog, provides a set of tools that allows data access for astronomers and scientific education. One of SkyServer data access interfaces allows users to enter ad-hoc SQL statements to query the catalog. SkyServer also presents some template queries that can be used as basis for more complex queries. This interface has logged over 330 million queries submitted since 2001. It is expected that analysis of this data can be used to investigate usage patterns, identify potential new classes of queries, find similar queries, etc. and to shed some light on how users interact with the Sloan Digital Sky Survey data and how scientists have adopted the new paradigm of e-Science, which could in turn lead to enhancements on the user interfaces and experience in general. In this paper we review some approaches to SQL query mining, apply the traditional techniques used in the literature and present lessons learned, namely, that the general text mining approach for feature extraction and clustering does not seem to be adequate for this type of data, and, most importantly, we find that this type of analysis can result in very different queries being clustered together.

  16. Measuring the influence of aerosols and albedo on sky polarization.

    Science.gov (United States)

    Kreuter, A; Emde, C; Blumthaler, M

    2010-11-01

    All-sky distributions of the polarized radiance are measured using an automated fish-eye camera system with a rotating polarizer. For a large range of aerosol and surface albedo situations, the influence on the degree of polarization and sky radiance is investigated. The range of aerosol optical depth and albedo is 0.05-0.5 and 0.1-0.75, respectively. For this range of parameters, a reduction of the degree of polarization from about 0.7 to 0.4 was observed. The analysis is done for 90° scattering angle in the principal plane under clear sky conditions for a broadband channel of 450 ± 25 nm and solar zenith angles between 55° and 60°. Radiative transfer calculations considering three different aerosol mixtures are performed and and agree with the measurements within the statistical error.

  17. A simple formula for determining globally clear skies

    Energy Technology Data Exchange (ETDEWEB)

    Long, C.N.; George, A.T.; Mace, G.G. [Penn State Univ., University Park, PA (United States)] [and others

    1996-04-01

    Surface measurements to serve as {open_quotes}ground truth{close_quotes} are of primary importance in the development of retrieval algorithms using satellite measurements to predict surface irradiance. The most basic algorithms of this type deal with clear sky (i.e., cloudless) top-to-surface shortwave (SW) transfer, serving as a necessary prerequisite towards treating both clear and cloudy conditions. Recently, atmosphere SW cloud forcing to infer the possibility of excess atmospheric absorption (compared with model results) in cloudy atmospheres. The surface component of this ratio relies on inferring the expected clear sky SW irradiance to determine the effects of clouds on the SW energy budget. Solar renewable energy applications make use of clear and cloud fraction climatologies to assess solar radiation resources. All of the above depend to some extent on the identification of globally clear sky conditions and the attendant measurements of downwelling SW irradiance.

  18. An All-Sky Portable (ASP) Optical Catalogue

    Science.gov (United States)

    Flesch, Eric Wim

    2017-06-01

    This optical catalogue combines the all-sky USNO-B1.0/A1.0 and most-sky APM catalogues, plus overlays of SDSS optical data, into a single all-sky map presented in a sparse binary format that is easily downloaded at 9 Gb zipped. Total count is 1 163 237 190 sources and each has J2000 astrometry, red and blue magnitudes with PSFs and variability indicator, and flags for proper motion, epoch, and source survey and catalogue for each of the photometry and astrometry. The catalogue is available on http://quasars.org/asp.html, and additional data for this paper is available at http://dx.doi.org/10.4225/50/5807fbc12595f.

  19. Radiative sky cooling: fundamental physics, materials, structures, and applications

    Science.gov (United States)

    Sun, Xingshu; Sun, Yubo; Zhou, Zhiguang; Alam, Muhammad Ashraful; Bermel, Peter

    2017-07-01

    Radiative sky cooling reduces the temperature of a system by promoting heat exchange with the sky; its key advantage is that no input energy is required. We will review the origins of radiative sky cooling from ancient times to the modern day, and illustrate how the fundamental physics of radiative cooling calls for a combination of properties that may not occur in bulk materials. A detailed comparison with recent modeling and experiments on nanophotonic structures will then illustrate the advantages of this recently emerging approach. Potential applications of these radiative cooling materials to a variety of temperature-sensitive optoelectronic devices, such as photovoltaics, thermophotovoltaics, rectennas, and infrared detectors, will then be discussed. This review will conclude by forecasting the prospects for the field as a whole in both terrestrial and space-based systems.

  20. Gods, Demons and Deceivers: Jesuits Facing Chaco Skies

    Science.gov (United States)

    López, Alejandro Martín

    2015-05-01

    The Jesuit missions located in the Chaco are less known than the ones in Paraguay. They are the last step of the Jesuits' missionary device in the Rio de la Plata region. They were dedicated to 'evangelize' and 'civilize' the aboriginal groups considered more hostile: nomadic hunter-gatherers who adopted the use of horses and were not controlled by the colonial government. These groups were seen by Europeans as a radical otherness. That is why the Jesuits' descriptions of Chaco Indian skies are a very interesting example about European attitudes toward other worldviews. This paper explores the use of different paradigms for interpreting these alternative skies: demonic influence, the deception of sorcerers and an Evemeristic reading of the indigenous worldview. This article also addresses some of the interactions between the aboriginal and Christian skies in the mission context.

  1. Night sky a field guide to the constellations

    CERN Document Server

    Poppele, Jonathan

    2009-01-01

    Stargazing is among the most peaceful and inspiring outdoor activities. Night Sky, the award-winning book by Jonathan Poppele, makes it more fun than ever! Take a simple approach to finding 62 constellations by focusing on one constellation at a time, instead of attempting to study dizzying charts. Start with the easy-to-find constellations during each season and work toward the more difficult ones. Better yet, you'll learn how to locate any constellation in relation to the Big Dipper, the North Star and the top of the sky. With two ways to locate each constellation, you'll know where in the sky to look and what to look for! Along the way, you'll be introduced to mythology, facts and tidbits, as well as details about the planets, solar system and more! As an added bonus, the book comes with a red-light flashlight for night reading.

  2. Dark Sky Collaborators: Arizona (AZ) Observatories, Communities, and Businesses

    Science.gov (United States)

    Del Castillo, Elizabeth Alvarez; Corbally, Christopher; Falco, Emilio E.; Green, Richard F.; Hall, Jeffrey C.; Williams, G. Grant

    2015-03-01

    With outdoor lighting ordinances in Arizona first in place around observatories in 1958 and 1972, then throughout the state since 1986, Arizonans have extensive experience working with communities and businesses to preserve our dark skies. Though communities are committed to the astronomy sector in our state, astronomers must collaborate with other stakeholders to implement solutions. Ongoing education and public outreach is necessary to enable ordinance updates as technology changes. Despite significant population increases, sky brightness measurements over the last 20 years show that ordinance updates are worth our efforts as we seek to maintain high quality skies around our observatories. Collaborations are being forged and actions taken to promote astronomy for the longer term in Arizona.

  3. Cooling load reduction by means of night sky radiation

    International Nuclear Information System (INIS)

    Kamaruddin Abdullah; Armansyah, H.T.; Dyah, W.; Gunadnya, I.B.P.

    2006-01-01

    Nocturnal cooling can work under clear sky condition of the humid tropical climate. Such effect had been observed in a cool storage facilities for potatoes and for temporary storage of fresh vegetables installed in highland area of Candi kuning village of Bali. Test results have shown that the rate of heat dissipation to the sky could reduce storage temperature to 15 o C had been achieved when the nocturnal cooling unit was combined with modified cooling tower and 1 kW cooling effect of an auxiliary cooling unit. Under such condition the facility could maintain better quality of stored vegetables, such as broccoli, shallot, and celery as compared to those stored in room without cooling facility. The estimated average cooling rate due to night sky radiation was 47.6 W/m 2 , on September 28, 1999 and 47.2 W/m 2 with the lowest water temperature of 14 o C under ambient temperature of 16 o C

  4. Providing Diurnal Sky Cover Data at ARM Sites

    Energy Technology Data Exchange (ETDEWEB)

    Klebe, Dimitri I. [Solmirus Corporation, Colorado Springs, CO (United States)

    2015-03-06

    The Solmirus Corporation was awarded two-year funding to perform a comprehensive data analysis of observations made during Solmirus’ 2009 field campaign (conducted from May 21 to July 27, 2009 at the ARM SGP site) using their All Sky Infrared Visible Analyzer (ASIVA) instrument. The objective was to develop a suite of cloud property data products for the ASIVA instrument that could be implemented in real time and tailored for cloud modelers. This final report describes Solmirus’ research and findings enabled by this grant. The primary objective of this award was to develop a diurnal sky cover (SC) data product utilizing the ASIVA’s infrared (IR) radiometrically-calibrated data and is described in detail. Other data products discussed in this report include the sky cover derived from ASIVA’s visible channel and precipitable water vapor, cloud temperature (both brightness and color), and cloud height inferred from ASIVA’s IR channels.

  5. Radiative sky cooling: fundamental physics, materials, structures, and applications

    Directory of Open Access Journals (Sweden)

    Sun Xingshu

    2017-07-01

    Full Text Available Radiative sky cooling reduces the temperature of a system by promoting heat exchange with the sky; its key advantage is that no input energy is required. We will review the origins of radiative sky cooling from ancient times to the modern day, and illustrate how the fundamental physics of radiative cooling calls for a combination of properties that may not occur in bulk materials. A detailed comparison with recent modeling and experiments on nanophotonic structures will then illustrate the advantages of this recently emerging approach. Potential applications of these radiative cooling materials to a variety of temperature-sensitive optoelectronic devices, such as photovoltaics, thermophotovoltaics, rectennas, and infrared detectors, will then be discussed. This review will conclude by forecasting the prospects for the field as a whole in both terrestrial and space-based systems.

  6. Optical Sky Brightness and Transparency during the Winter Season at Dome A Antarctica from the Gattini-All-Sky Camera

    Science.gov (United States)

    Yang, Yi; Moore, Anna M.; Krisciunas, Kevin; Wang, Lifan; Ashley, Michael C. B.; Fu, Jianning; Brown, Peter J.; Cui, Xiangqun; Feng, Long-Long; Gong, Xuefei; Hu, Zhongwen; Lawrence, Jon S.; Luong-Van, Daniel; Riddle, Reed L.; Shang, Zhaohui; Sims, Geoff; Storey, John W. V.; Suntzeff, Nicholas B.; Tothill, Nick; Travouillon, Tony; Yang, Huigen; Yang, Ji; Zhou, Xu; Zhu, Zhenxi

    2017-07-01

    The summit of the Antarctic plateau, Dome A, is proving to be an excellent site for optical, near-infrared, and terahertz astronomical observations. Gattini is a wide-field camera installed on the PLATO instrument module as part of the Chinese-led traverse to Dome A in 2009 January. We present here the measurements of sky brightness with the Gattini ultra-large field of view (90^\\circ × 90^\\circ ) in the photometric B-, V-, and R-bands; cloud cover statistics measured during the 2009 winter season; and an estimate of the sky transparency. A cumulative probability distribution indicates that the darkest 10% of the nights at Dome A have sky brightness of S B = 22.98, S V = 21.86, and S R = 21.68 mag arcsec-2. These values were obtained during the year 2009 with minimum aurora, and they are comparable to the faintest sky brightness at Maunakea and the best sites of northern Chile. Since every filter includes strong auroral lines that effectively contaminate the sky brightness measurements, for instruments working around the auroral lines, either with custom filters or with high spectral resolution instruments, these values could be easily obtained on a more routine basis. In addition, we present example light curves for bright targets to emphasize the unprecedented observational window function available from this ground-based site. These light curves will be published in a future paper.

  7. Dark Skies Awareness Programs for the International Year of Astronomy

    Science.gov (United States)

    Walker, Constance E.; US IYA Dark Skies Working Group

    2009-05-01

    The arc of the Milky Way seen from a truly dark location is part of our planet's cultural and natural heritage. More than 1/5 of the world population, 2/3 of the United States population and 1/2 of the European Union population have already lost naked-eye visibility of the Milky Way. This loss, caused by light pollution, is a serious and growing issue that impacts astronomical research, the economy, ecology, energy conservation, human health, public safety and our shared ability to see the night sky. For this reason, "Dark Skies” is a cornerstone project of the International Year of Astronomy. Its goal is to raise public awareness of the impact of artificial lighting on local environments by getting people worldwide involved in a variety of programs that: 1) Teach about dark skies using new technology (e.g., an activity-based planetarium show on DVD, podcasting, social networking on Facebook and MySpace, a Second Life presence) 2) Provide thematic events on light pollution at star parties and observatory open houses (Dark Skies Discovery Sites, Nights in the (National) Parks, Sidewalk Astronomy) 3) Organize events in the arts (e.g., a photography contest) 4) Involve citizen-scientists in naked-eye and digital-meter star hunting programs (e.g., GLOBE at Night, "How Many Stars?", the Great World Wide Star Count and the radio frequency interference equivalent: "Quiet Skies") and 5) Raise awareness about the link between light pollution and public health, economic issues, ecological consequences, energy conservation, safety and security, and astronomy (e.g., The Starlight Initiative, World Night in Defense of Starlight, International Dark Sky Week, International Dark-Sky Communities, Earth Hour, The Great Switch Out, a traveling exhibit, downloadable posters and brochures). The poster will provide an update, describe how people can continue to participate, and take a look ahead at the program's sustainability. For more information, visit www.darkskiesawareness.org.

  8. Super-sample covariance approximations and partial sky coverage

    Science.gov (United States)

    Lacasa, Fabien; Lima, Marcos; Aguena, Michel

    2018-04-01

    Super-sample covariance (SSC) is the dominant source of statistical error on large scale structure (LSS) observables for both current and future galaxy surveys. In this work, we concentrate on the SSC of cluster counts, also known as sample variance, which is particularly useful for the self-calibration of the cluster observable-mass relation; our approach can similarly be applied to other observables, such as galaxy clustering and lensing shear. We first examined the accuracy of two analytical approximations proposed in the literature for the flat sky limit, finding that they are accurate at the 15% and 30-35% level, respectively, for covariances of counts in the same redshift bin. We then developed a harmonic expansion formalism that allows for the prediction of SSC in an arbitrary survey mask geometry, such as large sky areas of current and future surveys. We show analytically and numerically that this formalism recovers the full sky and flat sky limits present in the literature. We then present an efficient numerical implementation of the formalism, which allows fast and easy runs of covariance predictions when the survey mask is modified. We applied our method to a mask that is broadly similar to the Dark Energy Survey footprint, finding a non-negligible negative cross-z covariance, i.e. redshift bins are anti-correlated. We also examined the case of data removal from holes due to, for example bright stars, quality cuts, or systematic removals, and find that this does not have noticeable effects on the structure of the SSC matrix, only rescaling its amplitude by the effective survey area. These advances enable analytical covariances of LSS observables to be computed for current and future galaxy surveys, which cover large areas of the sky where the flat sky approximation fails.

  9. Fireballs in the Sky: An Augmented Reality Citizen Science Program

    Science.gov (United States)

    Day, Brian

    2017-01-01

    Fireballs in the Sky is an innovative Australian citizen science program that connects the public with the research of the Desert Fireball Network (DFN). This research aims to understand the early workings of the solar system, and Fireballs in the Sky invites people around the world to learn about this science, contributing fireball sightings via a user-friendly augmented reality mobile app. Tens of thousands of people have downloaded the app world-wide and participated in the science of meteoritics. The Fireballs in the Sky app allows users to get involved with the Desert Fireball Network research, supplementing DFN observations and providing enhanced coverage by reporting their own meteor sightings to DFN scientists. Fireballs in the Sky reports are used to track the trajectories of meteors - from their orbit in space to where they might have landed on Earth. Led by Phil Bland at Curtin University in Australia, the Desert Fireball Network (DFN) uses automated observatories across Australia to triangulate trajectories of meteorites entering the atmosphere, determine pre-entry orbits, and pinpoint their fall positions. Each observatory is an autonomous intelligent imaging system, taking 1000 by 36 megapixel all-sky images throughout the night, using neural network algorithms to recognize events. They are capable of operating for 12 months in a harsh environment, and store all imagery collected. We developed a completely automated software pipeline for data reduction, and built a supercomputer database for storage, allowing us to process our entire archive. The DFN currently stands at 50 stations distributed across the Australian continent, covering an area of 2.5 million square kilometers. Working with DFN's partners at NASA's Solar System Exploration Research Virtual Institute, the team is expanding the network beyond Australia to locations around the world. Fireballs in the Sky allows a growing public base to learn about and participate in this exciting research.

  10. Fireballs in the Sky: an Augmented Reality Citizen Science Program

    Science.gov (United States)

    Day, B. H.; Bland, P.; Sayers, R.

    2017-12-01

    Fireballs in the Sky is an innovative Australian citizen science program that connects the public with the research of the Desert Fireball Network (DFN). This research aims to understand the early workings of the solar system, and Fireballs in the Sky invites people around the world to learn about this science, contributing fireball sightings via a user-friendly augmented reality mobile app. Tens of thousands of people have downloaded the app world-wide and participated in the science of meteoritics. The Fireballs in the Sky app allows users to get involved with the Desert Fireball Network research, supplementing DFN observations and providing enhanced coverage by reporting their own meteor sightings to DFN scientists. Fireballs in the Sky reports are used to track the trajectories of meteors - from their orbit in space to where they might have landed on Earth. Led by Phil Bland at Curtin University in Australia, the Desert Fireball Network (DFN) uses automated observatories across Australia to triangulate trajectories of meteorites entering the atmosphere, determine pre-entry orbits, and pinpoint their fall positions. Each observatory is an autonomous intelligent imaging system, taking 1000×36Megapixel all-sky images throughout the night, using neural network algorithms to recognize events. They are capable of operating for 12 months in a harsh environment, and store all imagery collected. We developed a completely automated software pipeline for data reduction, and built a supercomputer database for storage, allowing us to process our entire archive. The DFN currently stands at 50 stations distributed across the Australian continent, covering an area of 2.5 million km^2. Working with DFN's partners at NASA's Solar System Exploration Research Virtual Institute, the team is expanding the network beyond Australia to locations around the world. Fireballs in the Sky allows a growing public base to learn about and participate in this exciting research.

  11. Protecting Dark Skies as a State-Wide Resource

    Science.gov (United States)

    Allen, Lori E.; Walker, Constance E.; Hall, Jeffrey C.; Larson, Steve; Williams, Grant; Falco, Emilio; Hinz, Joannah; Fortin, Pascal; Brocious, Dan; Corbally, Christopher; Gabor, Paul; Veillet, Christian; Shankland, Paul; Jannuzi, Buell; Cotera, Angela; Luginbuhl, Christian

    2018-01-01

    The state of Arizona contains the highest concentration of research telescopes in the continental United States, contributing more than a quarter of a billion dollars annually to the state's economy. Protecting the dark skies above these observatories is both good for astronomy and good for the state's economy. In this contribution we describe how a coalition of Arizona observatories is working together to protect our dark skies. Efforts date back to the creation of one of the first Outdoor Lighting Codes in the United States and continue today, including educational outreach, public policy engagement, and consensus building. We review some proven strategies, highlight recent successes and look at current threats.

  12. Variable X-ray sky with Lobster Eye Telescopes

    International Nuclear Information System (INIS)

    Hudec, R.; Pina, L.; Inneman, A.; Sveda, L.

    2004-01-01

    The variable X-ray sky requires wide-field monitoring with high sensitivity. We refer on novel X-ray telescopes with high sensitivity as well as large field of view. The results are very promising, allowing the proposals for space projects with very wide-field Lobster-eye X-ray optics to be considered. The novel telescopes will monitor the sky with unprecedented sensitivity and angular resolution of order of 1 arcmin. They are expected to contribute essentially to study and to understand various astrophysical objects such as AGN, SNe, GRBs, X-ray flashes, galactic binary sources, stars, CVs, X-ray novae, various transient sources, etc

  13. The Sloan Digital Sky Survey: Status and prospects

    Energy Technology Data Exchange (ETDEWEB)

    Loveday, J.; SDSS Collaboration

    1996-05-01

    The Sloan Digital Sky Survey (SDSS) is a project to definitively map {pi} steradians of the local Universe. An array of CCD detectors used in drift-scan mode will digitally image the sky in five passbands to a limiting magnitude of r{prime} {approximately} 23. Selected from the imaging survey, 10{sup 6} galaxies and 10{sup 5} quasars will be observed spectroscopically. I describe the current status of the survey, which is due to begin observations early in 1997, and its prospects for constraining models for dark matter in the Universe. 8 refs., 7 figs.

  14. 2MASS - The 2 Micron All Sky Survey

    Science.gov (United States)

    Kleinmann, S. G.

    1992-01-01

    This paper describes a new sky survey to be carried out in three wavebands, J(1.25 m), H(1.65 m), and K(2.2 m). The limiting sensitivity of the survey, 10 sigma detection of point sources with K not greater than 14 mag, coupled with its all-sky coverage, were selected primarily to support studies of the large-scale structure of the Milky Way and the Local Universe. The survey requires construction of a pair of observing facilities, one each for the Northern and Southern Hemispheres. Operations are scheduled to begin in 1995. The data will begin becoming publicly available soon thereafter.

  15. The pre-launch Planck Sky Model: a model of sky emission at submillimetre to centimetre wavelengths

    CERN Document Server

    Delabrouille, J.; Melin, J.-B.; Miville-Deschenes, M.-A.; Gonzalez-Nuevo, J.; Jeune, M.Le; Castex, G.; de Zotti, G.; Basak, S.; Ashdown, M.; Aumont, J.; Baccigalupi, C.; Banday, A.; Bernard, J.-P.; Bouchet, F.R.; Clements, D.L.; da Silva, A.; Dickinson, C.; Dodu, F.; Dolag, K.; Elsner, F.; Fauvet, L.; Fay, G.; Giardino, G.; Leach, S.; Lesgourgues, J.; Liguori, M.; Macias-Perez, J.F.; Massardi, M.; Matarrese, S.; Mazzotta, P.; Montier, L.; Mottet, S.; Paladini, R.; Partridge, B.; Piffaretti, R.; Prezeau, G.; Prunet, S.; Ricciardi, S.; Roman, M.; Schaefer, B.; Toffolatti, L.

    2012-01-01

    We present the Planck Sky Model (PSM), a parametric model for the generation of all-sky, few arcminute resolution maps of sky emission at submillimetre to centimetre wavelengths, in both intensity and polarisation. Several options are implemented to model the cosmic microwave background, Galactic diffuse emission (synchrotron, free-free, thermal and spinning dust, CO lines), Galactic H-II regions, extragalactic radio sources, dusty galaxies, and thermal and kinetic Sunyaev-Zeldovich signals from clusters of galaxies. Each component is simulated by means of educated interpolations/extrapolations of data sets available at the time of the launch of the Planck mission, complemented by state-of-the-art models of the emission. Distinctive features of the simulations are: spatially varying spectral properties of synchrotron and dust; different spectral parameters for each point source; modeling of the clustering properties of extragalactic sources and of the power spectrum of fluctuations in the cosmic infrared back...

  16. Photometric Analysis of the Pi of the Sky Data

    Directory of Open Access Journals (Sweden)

    M. Siudek

    2011-01-01

    Full Text Available A database containing star measurements from the period 2006–2009 taken by the Pi of the Sky detector located in Las Campanas Observatory in Chile contains more than 2 billion measurements of almost 17 million objects. All measurements are available on the Pi of the Sky web site through a dedicated interface, which also allows users to download selected data. Accurate analysis of Pi of the Sky data is a real challenge, because of a number of factors that can influence the measurements. Possible sources of errors in our measurements include: reading the chip with the shutter open, strong and varying sky background, passing planets or planetoids, and clouds and hot pixels. In order tofacilitate the analysis of variable stars we have developed a system of dedicated filters to remove bad measurements or frames. The spectral sensitivity of the detector is taken into account by appropriate corrections based on the spectral type of reference stars. This process is illustrated by an analysis of the BG Ind system, where we have been able to reduce the systematic uncertainty to about 0.05 magnitudo.

  17. Reflective all-sky thermal infrared cloud imager.

    Science.gov (United States)

    Redman, Brian J; Shaw, Joseph A; Nugent, Paul W; Clark, R Trevor; Piazzolla, Sabino

    2018-04-30

    A reflective all-sky imaging system has been built using a long-wave infrared microbolometer camera and a reflective metal sphere. This compact system was developed for measuring spatial and temporal patterns of clouds and their optical depth in support of applications including Earth-space optical communications. The camera is mounted to the side of the reflective sphere to leave the zenith sky unobstructed. The resulting geometric distortion is removed through an angular map derived from a combination of checkerboard-target imaging, geometric ray tracing, and sun-location-based alignment. A tape of high-emissivity material on the side of the reflector acts as a reference that is used to estimate and remove thermal emission from the metal sphere. Once a bias that is under continuing study was removed, sky radiance measurements from the all-sky imager in the 8-14 μm wavelength range agreed to within 0.91 W/(m 2 sr) of measurements from a previously calibrated, lens-based infrared cloud imager over its 110° field of view.

  18. The new world atlas of artificial night sky brightness.

    Science.gov (United States)

    Falchi, Fabio; Cinzano, Pierantonio; Duriscoe, Dan; Kyba, Christopher C M; Elvidge, Christopher D; Baugh, Kimberly; Portnov, Boris A; Rybnikova, Nataliya A; Furgoni, Riccardo

    2016-06-01

    Artificial lights raise night sky luminance, creating the most visible effect of light pollution-artificial skyglow. Despite the increasing interest among scientists in fields such as ecology, astronomy, health care, and land-use planning, light pollution lacks a current quantification of its magnitude on a global scale. To overcome this, we present the world atlas of artificial sky luminance, computed with our light pollution propagation software using new high-resolution satellite data and new precision sky brightness measurements. This atlas shows that more than 80% of the world and more than 99% of the U.S. and European populations live under light-polluted skies. The Milky Way is hidden from more than one-third of humanity, including 60% of Europeans and nearly 80% of North Americans. Moreover, 23% of the world's land surfaces between 75°N and 60°S, 88% of Europe, and almost half of the United States experience light-polluted nights.

  19. Evolution of the Air Toxics under the Big Sky Program

    Science.gov (United States)

    Marra, Nancy; Vanek, Diana; Hester, Carolyn; Holian, Andrij; Ward, Tony; Adams, Earle; Knuth, Randy

    2011-01-01

    As a yearlong exploration of air quality and its relation to respiratory health, the "Air Toxics Under the Big Sky" program offers opportunities for students to learn and apply science process skills through self-designed inquiry-based research projects conducted within their communities. The program follows a systematic scope and sequence…

  20. Sky brightness and twilight measurements at Jogyakarta city, Indonesia

    International Nuclear Information System (INIS)

    Herdiwijaya, Dhani

    2016-01-01

    The sky brightness measurements were performed using a portable photometer. A pocket-sized and low-cost photometer has 20 degree area measurement, and spectral ranges between 320-720 nm with output directly in magnitudes per arc second square (mass) unit. The sky brightness with 3 seconds temporal resolutions was recorded at Jogyakarta city (110° 25’ E; 70° 52’ S; elevation 100 m) within 136 days in years from 2014 to 2016. The darkest night could reach 22.61 mpass only in several seconds, with mean value 18.8±0.7 mpass and temperature variation 23.1±1.2 C. The difference of mean sky brightness between before and after midnight was about -0.76 mpass or 2.0 times brighter. Moreover, the sky brightness and temperature fluctuations were more stable in after midnight than in before midnight. It is suggested that city light pollution affects those variations, and subsequently duration of twilight. By comparing twilight brightness for several places, we also suggest a 17° solar dip or about 66 minutes before sunrise for new time of Fajr prayer. (paper)

  1. A Study of Sasin-Animal Sky Map on Chonmunryucho

    Directory of Open Access Journals (Sweden)

    Hong-Jin Yang

    2003-03-01

    Full Text Available Chon-Mun-Ryu-Cho, written (edited by Lee Sun-Ji during the period of King Se-Jong, is a representative astronomy book of Cho-Sun (A.D. 1392 -1910 Dynasty. We find and study in the first page of the book; the description of 28 oriental constellations as a Sasin (four mythical oriental animals-animal sky map which is not widely known yet. The map consists of four groups of constellations, each of which represents the Sasin: Chang-Ryong (dragon, Baek-Ho (tigers with Ki-Rin [Oriental giraffe], Ju-Jak (Chinese phoenix, Hyun-Mu (a tortoise interwined with a snake. Each group (animals spans 2˜7 of 28 oriental constellations As we know from the illustration of the Chon-Sang-Yol-Cha-Bun-Ya-Ji-Do a representative sky map of Cho-Sun Dynasty, astronomy in Cho-Sun Dynasty is closely related to that in Go-Gu-Ryer (B.C. 37 -A.D. 668 Dynasty. Since these Sasin-animals appear in most mural paintings of Go-Gu-Ryer tombs, visualization of sky with these animal constellations could have been established as early as in Go-Gu-Ryer Dynasty. We also reconstruct this ''A Sasin-animal Korean sky map'' based on the shapes of the Sasin and Ki-Rin from Go-Gu-Ryer paintings and 28 oriental constellations in Chon-Sang-Yol-Cha-Bun-Ya-Ji-Do.

  2. Sun, Sky and Cloud: Where Light and Matter Meet

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 20; Issue 12. Sun, Sky and Cloud: Where Light and Matter Meet. Rajaram Nityananda. General Article Volume 20 Issue 12 December 2015 pp 1111-1127. Fulltext. Click here to view fulltext PDF. Permanent link:

  3. The Fourteenth Data Release of the Sloan Digital Sky Survey

    DEFF Research Database (Denmark)

    Abolfathi, Bela; Aguado, D. S.; Aguilar, Gabriela

    2018-01-01

    The fourth generation of the Sloan Digital Sky Survey (SDSS-IV) has been in operation since 2014 July. This paper describes the second data release from this phase, and the 14th from SDSS overall (making this Data Release Fourteen or DR14). This release makes the data taken by SDSS-IV in its firs...

  4. Photometric Variability in the Faint Sky Variability Survey

    NARCIS (Netherlands)

    Morales-Rueda, L.; Groot, P.J.; Augusteijn, T.; Nelemans, G.A.; Vreeswijk, P.M.; Besselaar, E.J.M. van den

    2005-01-01

    The Faint Sky Variability Survey (FSVS) is aimed at finding photometric and/or astrometric variable objects between 16th and 24th mag on time-scales between tens of minutes and years with photometric precisions ranging from 3 millimag to 0.2 mag. An area of ~23 deg2, located at mid and

  5. Decade of wildlife tracking in the Sky Islands

    Science.gov (United States)

    Jessica A. Lamberton-Moreno; Sergio Avila-Villegas

    2013-01-01

    In 2001 Sky Island Alliance developed a citizen science program that uses track and sign identification and count surveys to monitor potential wildlife corridors throughout southeastern Arizona and southwestern New Mexico. The goal of the Wildlife Linkages Program is to protect and advocate for an interconnected landscape where wildlife, based on their ecological needs...

  6. Inferences from the dark sky: Olbers' paradox revisited

    International Nuclear Information System (INIS)

    Arpino, Mauro; Scardigli, Fabio

    2003-01-01

    The classical formulation of 'Olbers' paradox' consists in looking for an explanation of the fact that the sky at night is dark. We use the experimental datum of the nocturnal darkness in order to put constraints on a Newtonian cosmological model. We infer then that the stellar system in such a model should have had an origin at a finite time in the past

  7. Citizen Sky, IYA 2009 and What's To Come

    Science.gov (United States)

    Turner, Rebecca; Price, A.; Henden, A.

    2010-01-01

    Citizen Sky is a multi-year, NSF funded citizen science project involving the bright and mysterious variable star eps Aur. The project was conceived by the IYA 2009 working group on Research Experiences for Students, Teachers, and Citizen-Scientists. Citizen Sky is going beyond simple observing to include a major data analysis component. The goal is to introduce the participant to the full scientific process from background research to paper writing for a peer-reviewed journal. During IYA 2009 the Citizen Sky team was fully assembled, the website was developed and put online, and the first of two participant workshops was held. However, Citizen Sky does not stop or even slow down with the conclusion of IYA 2009. The project will continue to grow in the coming years. New participants are being recruited and trained as the observing phase of the project continues, a second participant workshop is planned for 2010, and the data analysis phase of the project will begin in earnest.

  8. SkyMapper Southern Survey: First Data Release (DR1)

    Science.gov (United States)

    Wolf, Christian; Onken, Christopher A.; Luvaul, Lance C.; Schmidt, Brian P.; Bessell, Michael S.; Chang, Seo-Won; Da Costa, Gary S.; Mackey, Dougal; Martin-Jones, Tony; Murphy, Simon J.; Preston, Tim; Scalzo, Richard A.; Shao, Li; Smillie, Jon; Tisserand, Patrick; White, Marc C.; Yuan, Fang

    2018-02-01

    We present the first data release of the SkyMapper Southern Survey, a hemispheric survey carried out with the SkyMapper Telescope at Siding Spring Observatory in Australia. Here, we present the survey strategy, data processing, catalogue construction, and database schema. The first data release dataset includes over 66 000 images from the Shallow Survey component, covering an area of 17 200 deg2 in all six SkyMapper passbands uvgriz, while the full area covered by any passband exceeds 20 000 deg2. The catalogues contain over 285 million unique astrophysical objects, complete to roughly 18 mag in all bands. We compare our griz point-source photometry with Pan-STARRS1 first data release and note an RMS scatter of 2%. The internal reproducibility of SkyMapper photometry is on the order of 1%. Astrometric precision is better than 0.2 arcsec based on comparison with Gaia first data release. We describe the end-user database, through which data are presented to the world community, and provide some illustrative science queries.

  9. NIGHT SKY BRIGHTNESS ABOVE ZAGREB 2012.-2017.

    Directory of Open Access Journals (Sweden)

    Željko Andreić

    2018-01-01

    Full Text Available The night sky brightness at the RGN site (near the centre of Zagreb, Croatia was monitored form January 2012. to December 2017. The gathered data show that the average night sky brightness in this period did not change significantly, apart from differences caused by yearly variations in meteorological parameters. The nightly minima, maxima and mean values of the sky brightness do change considerably due to changes in meteorological conditions, often being between 2 and 3 magnitudes. The seasonal probability curves and histograms are constructed and are used to obtain additional information on the light pollution at the RGN site. They reveal that the night sky brightness clutters around two peaks, at about 15.0 mag/arcsec2 and at about 18.2 mag/arcsec2. The tendency to slightly lower brightness values in spring and summer can also be seen in the data. Two peaks correspond to cloudy and clear nights respectively, the difference in brightness between them being about 3 magnitudes. A crude clear/cloudy criterion can be defined too: the minimum between two peaks is around 16.7 mag/arcsec2. The brightness values smaller than thisare attributed to clear nights and vice-versa. Comparison with Vienna and Hong-Kong indicates that the light pollution of Zagreb is a few times larger.

  10. Adaptive modeling of sky for video processing and coding applications

    NARCIS (Netherlands)

    Zafarifar, B.; With, de P.H.N.; Lagendijk, R.L.; Weber, Jos H.; Berg, van den A.F.M.

    2006-01-01

    Video content analysis for still- and moving images can be used for various applications, such as high-level semantic-driven operations or pixel-level contentdependent image manipulation. Within video content analysis, sky regions of an image form visually important objects, for which interesting

  11. distribution of hourly variability index of sky clearness

    African Journals Online (AJOL)

    Mgina

    Clouds affect the values of insolation for solar technology and other applications. To detect the presence of variability in the sky ... It appears that the site has great potential for application of solar technologies. INTRODUCTION. Knowledge about the .... for solar collectors-part 1. Thermal performance of glazed liquid heating.

  12. Short timescale variability in the faint sky variability survey

    NARCIS (Netherlands)

    Morales-Rueda, L.; Groot, P.J.; Augusteijn, T.; Nelemans, G.A.; Vreeswijk, P.M.; Besselaar, E.J.M. van den

    2006-01-01

    We present the V-band variability analysis of the Faint Sky Variability Survey (FSVS). The FSVS combines colour and time variability information, from timescales of 24 minutes to tens of days, down to V = 24. We find that �1% of all point sources are variable along the main sequence reaching �3.5%

  13. Proof of Concept for a Simple Smartphone Sky Monitor

    Science.gov (United States)

    Kantamneni, Abhilash; Nemiroff, R. J.; Brisbois, C.

    2013-01-01

    We present a novel approach of obtaining a cloud and bright sky monitor by using a standard smartphone with a downloadable app. The addition of an inexpensive fisheye lens can extend the angular range to the entire sky visible above the device. A preliminary proof of concept image shows an optical limit of about visual magnitude 5 for a 70-second exposure. Support science objectives include cloud monitoring in a manner similar to the more expensive cloud monitors in use at most major astronomical observatories, making expensive observing time at these observatories more efficient. Primary science objectives include bright meteor tracking, bright comet tracking, and monitoring the variability of bright stars. Citizen science objectives include crowd sourcing of many networked sky monitoring smartphones typically in broader support of many of the primary science goals. The deployment of a citizen smartphone array in an active science mode could leverage the sky monitoring data infrastructure to track other non-visual science opportunities, including monitoring the Earth's magnetic field for the effects of solar flares and exhaustive surface coverage for strong seismic events.

  14. Gaia, an all-sky survey for standard photometry

    Science.gov (United States)

    Carrasco, J. M.; Weiler, M.; Jordi, C.; Fabricius, C.

    2017-03-01

    Gaia ESA's space mission (launched in 2013) includes two low resolution spectroscopic instruments (one in the blue, BP, and another in the red, RP, wavelength domains) to classify and derive the astrophysical parameters of the observed sources. As it is well known, Gaia is a full-sky unbiased survey down to about 20th magnitude. The scanning law yields a rather uniform coverage of the sky over the full extent (a minimum of 5 years) of the mission. Gaia data reduction is a global one over the full mission. Both sky coverage and data reduction strategy ensure an unprecedented all-sky homogeneous spectrophotometric survey. Certainly, that survey is of interest for current and future on-ground and space projects, like LSST, PLATO, EUCLID and J-PAS/J-PLUS among others. These projects will benefit from the large amount (more than one billion) and wide variety of objects observed by Gaia with good quality spectrophotometry. Synthetic photometry derived from Gaia spectrophotometry for any passband can be used to expand the set of standard sources for these new instruments to come. In the current Gaia data release scenario, BP/RP spectrophotometric data will be available in the third release (in 2018, TBC). Current preliminary results allow us to estimate the precision of synthetic photometry derived from the Gaia data. This already allows the preparation of the on-going and future surveys and space missions. We discuss here the exploitation of the Gaia spectrophotometry as standard reference due to its full-sky coverage and its expected photometric uncertainties derived from the low resolution Gaia spectra.

  15. Teaching Astronomy Through Art: Under Southern Skies -- Aboriginal and Western Scientific Perspectives of the Australian Night Sky

    Science.gov (United States)

    Majewski, S. R.; Boles, M. S.; Patterson, R. J.

    1999-12-01

    We have created an exhibit, Under Southern Skies -- Aboriginal and Western Scientific Perspectives of the Australian Night Sky, which has shown since June, 1999 in newly refurbished exhibit space at the Leander McCormick Observatory. The University of Virginia has a long and continuing tradition of astrometry starting with early parallax work at the McCormick Observatory, extending to our own NSF CAREER Award-funded projects, and including a long-term, ongoing southern parallax program at Mt. Stromlo and Siding Springs Observatories in Australia. Recently, through a gift of Mr. John Kluge, the University of Virginia has obtained one of the most extensive collections of Australian Aboriginal art outside of Australia. The goal of our exhibit is to unite the University's scientific, artistic and cultural connections to Australia through an exhibit focusing on different perspectives of the Australian night sky. We have brought together Australian Aboriginal bark and canvas paintings that feature astronomical themes, e.g., Milky Way, Moon, Magellanic Cloud and Seven Sisters Dreamings, from the Kluge-Ruhe and private collections. These paintings, from the Central Desert and Arnhem Land regions of Australia, are intermingled with modern, large format, color astronomical images of the same scenes. Descriptive panels and a small gallery guide explain the cultural, artistic and scientific aspects of the various thematic groupings based on particular southern hemisphere night sky objects and associated Aboriginal traditions and stories. This unusual combination of art and science not only provides a unique avenue for educating the public about both astronomy and Australian Aboriginal culture, but highlights mankind's ancient and continuing connection to the night sky. We appreciate funding from NSF CAREER Award #AST-9702521, a Cottrell Scholar Award from The Research Corporation, and the Dept. of Astronomy and Ruhe-Kluge Collection at the University of Virginia.

  16. 40 CFR 1048.140 - What are the provisions for certifying Blue Sky Series engines?

    Science.gov (United States)

    2010-07-01

    ... Blue Sky Series engines? 1048.140 Section 1048.140 Protection of Environment ENVIRONMENTAL PROTECTION... Sky Series engines? This section defines voluntary standards for a recognized level of superior emission control for engines designated as “Blue Sky Series” engines. If you certify an engine family under...

  17. Losing Sleep to Watch the Night-Sky: The Relationship between Sleep-Length and Noctcaelador

    Science.gov (United States)

    Kelly, William E.; Rose, Callie

    2005-01-01

    For most of history, humans have been watching the night-sky (Hawkins, 1983). Historically, individuals have watched the night-sky for aesthetic appreciation and to gain insights and knowledge (Brecher & Feirtag, 1979). Despite the long history of night-sky watching among humans and the apparent importance of the behavior to large groups of…

  18. The First Data Release of the Sloan Digital Sky Survey

    CERN Document Server

    Abazajian, Kevork; Agüeros, Marcel A.; Allam, Sahar S.; Anderson, Scott F.; Annis, James; Bahcall, Neta A.; Baldry, Ivan K.; Bastian, Steven; AndreasBerlind; Bernardi, Mariangela; Blanton, Michael R.; Blythe, Norman; Bochanski, John J.; Boroski, William N.; Brewington, Howard; Briggs, John W.; Brinkmann, J.; Brunner, Robert J.; Budavari, Tamas; Carey, Larry N.; Carr, Michael A.; Castander, Francisco J.; Chiu, Kuenley; Collinge, Matthew J.; Connolly, A. J.; Covey, Kevin R.; Csabai, István; J.Dalcanton, Julianne; Dodelson, Scott; Doi, Mamoru; Dong, Feng; Eisenstein, Daniel J.; L.Evans, Michael; Fan, Xiaohui; Feldman, Paul D.; Finkbeiner, Douglas P.; Friedman, Scott D.; Frieman, JoshuaA.; Fukugita, Masataka; Gal, Roy R.; Gillespie, Bruce; Glazebrook, Karl; F.Gonzalez, Carlos; Gray, Jim; Grebel, Eva K.; Grodnicki, Lauren; Gunn, James E.; K.Gurbani, Vijay; Hall, Patrick B.; Hao, Lei; Harbeck, Daniel; Harris, Frederick H.; C.Harris, Hugh; Harvanek, Michael; Hawley, Suzanne L.; Heckman, Timothy M.; Helmboldt, J. F.; Hendry, John S.; Hennessy, Gregory S.; Hindsley, Robert B.; Hogg, David W.; J.Holmgren, Donald; Holtzman, Jon A.; Homer, Lee; Hui, Lam; Ichikawa, Shin-ichi; Ichikawa, Takashi; Inkmann, John P.; ˇ, Zeljko Ivezíc; Jester, Sebastian; Johnston, David E.; Jordan, Beatrice; Jordan, Wendell P.; Jorgensen, Anders M.; Juríc, Mario; Kauffmann, Guinevere; M.Kent, Stephen; Kleinman, S. J.; Knapp, G. R.; Kniazev, Alexei Yu.; Kron, Richard G.; JurekKrzesinski; Kunszt, Peter Z.; Kuropatkin, Nickolai; Lamb, Donald Q.; Lampeitl, Hubert; Laubscher, Bryan E.; Lee, Brian C.; Leger, R. French; Li, Nolan; Lidz, Adam; Lin, Huan; Loh, Yeong-Shang; Long, Daniel C.; Loveday, Jon; Lupton, Robert H.; Malik, Tanu; BruceMargon; McGehee, Peregrine M.; McKay, Timothy A.; Meiksin, Avery; A.Miknaitis, Gajus; Moorthy, Bhasker K.; Munn, Jeffrey A.; Murphy, Tara; Nakajima, Reiko; Narayanan, VijayK.; Nash, Thomas; Neilsen, Eric H. Jr.; Newberg, Heidi Jo; Newman, Peter R.; Nichol, Robert C.; Nicinski, Tom; Nieto-Santisteban, Maria; Nitta, Atsuko; MichaelOdenkirchen; Okamura, Sadanori; Ostriker, Jeremiah P.; Owen, Russell; NikhilPadmanabhan; Peoples, John; Pier, Jeffrey R.; Pindor, Bartosz; Pope, Adrian C.; R.Quinn, Thomas; Rafikov, R. R.; Raymond, Sean N.; Richards, Gordon T.; Richmond, Michael W.; Rix, Hans-Walter; Rockosi, Constance M.; Schaye, Joop; Schlegel, David J.; P.Schneider, Donald; Schroeder, Joshua; Scranton, Ryan; Sekiguchi, Maki; Seljak, Uros; Sergey, Gary; Sesar, Branimir; Sheldon, Erin; Shimasaku, Kazu; Siegmund, Walter A.; Silvestri, Nicole M.; Sinisgalli, Allan J.; Sirko, Edwin; Smith, J. Allyn; Smolčíc, Vernesa; Snedden, Stephanie A.; Stebbins, Albert; Steinhardt, Charles; Stinson, Gregory; Stoughton, Chris; Strateva, Iskra V.; Strauss, Michael A.; SubbaRao, Mark; Szalay, Alexander S.; Szapudi, István; Szkody, Paula; Tasca, Lidia; Tegmark, Max; Thakar, Aniruddha R.; Tremonti, Christy; Tucker, Douglas L.; Uomoto, Alan; Vanden Berk, Daniel E.; Vandenberg, Jan; Vogeley, Michael S.; WolfgangVoges; Vogt, Nicole P.; Walkowicz, Lucianne M.; Weinberg, David H.; West, Andrew A.; White, Simon D.M.; Wilhite, Brian C.; Willman, Beth; Xu, Yongzhong; Yanny, Brian; JeanYarger; Yasuda, Naoki; Yip, Ching-Wa; Yocum, D. R.; York, Donald G.; L.Zakamska, Nadia; Zehavi, Idit; Zheng, Wei; Zibetti, Stefano; Zucker, Daniel B.

    2003-01-01

    The Sloan Digital Sky Survey has validated and made publicly available its First Data Release. This consists of 2099 square degrees of five-band (u, g, r, i, z) imaging data, 186,240 spectra of galaxies, quasars, stars and calibrating blank sky patches selected over 1360 square degrees of this area, and tables of measured parameters from these data. The imaging data go to a depth of r ~ 22.6 and are photometrically and astrometrically calibrated to 2% rms and 100 milli-arcsec rms per coordinate, respectively. The spectra cover the range 3800--9200 A, with a resolution of 1800--2100. Further characteristics of the data are described, as are the data products themselves.

  19. Exploring Ancient Skies A Survey of Ancient and Cultural Astronomy

    CERN Document Server

    Kelley, David H

    2011-01-01

    Exploring Ancient Skies brings together the methods of archaeology and the insights of modern astronomy to explore the science of astronomy as it was practiced in various cultures prior to the invention of the telescope. The book reviews an enormous and growing body of literature on the cultures of the ancient Mediterranean, the Far East, and the New World (particularly Mesoamerica), putting the ancient astronomical materials into their archaeological and cultural contexts. The authors begin with an overview of the field and proceed to essential aspects of naked-eye astronomy, followed by an examination of specific cultures. The book concludes by taking into account the purposes of ancient astronomy: astrology, navigation, calendar regulation, and (not least) the understanding of our place and role in the universe. Skies are recreated to display critical events as they would have appeared to ancient observers—events such as the supernova of 1054 A.D., the "lion horoscope," and the Star of Bethlehem. Explori...

  20. Exploring Ancient Skies An Encyclopedic Survey of Archaeoastronomy

    CERN Document Server

    Kelley, David H

    2005-01-01

    Exploring Ancient Skies brings together the methods of archaeology and the insights of modern astronomy to explore the science of astronomy as it was practiced in various cultures prior to the invention of the telescope. The book reviews an enormous and growing body of literature on the cultures of the ancient Mediterranean, the Far East, and the New World (particularly Mesoamerica), putting the ancient astronomical materials into their archaeological and cultural contexts. The authors begin with an overview of the field and proceed to essential aspects of naked-eye astronomy, followed by an examination of specific cultures. The book concludes by taking into account the purposes of ancient astronomy: astrology, navigation, calendar regulation, and (not least) the understanding of our place and role in the universe. Skies are recreated to display critical events as they would have appeared to ancient observers - events such as the supernova of 1054, the 'lion horoscope' or the 'Star of Bethlehem.' Exploring An...

  1. SED16 autonomous star tracker night sky testing

    Science.gov (United States)

    Foisneau, Thierry; Piriou, Véronique; Perrimon, Nicolas; Jacob, Philippe; Blarre, Ludovic; Vilaire, Didier

    2017-11-01

    The SED16 is an autonomous multi-missions star tracker which delivers three axis satellite attitude in an inertial reference frame and the satellite angular velocity with no prior information. The qualification process of this star sensor includes five validation steps using optical star simulator, digitized image simulator and a night sky tests setup. The night sky testing was the final step of the qualification process during which all the functions of the star tracker were used in almost nominal conditions : Autonomous Acquisition of the attitude, Autonomous Tracking of ten stars. These tests were performed in Calern in the premises of the OCA (Observatoire de la Cote d'Azur). The test set-up and the test results are described after a brief review of the sensor main characteristics and qualification process.

  2. Blue Sky Funders Forum - Advancing Environmental Literacy through Funder Collaboration

    Science.gov (United States)

    Chen, A.

    2015-12-01

    The Blue Sky Funders Forum inspires, deepens, and expands private funding and philanthropic leadership to promote learning opportunities that connect people and nature and promote environmental literacy. Being prepared for the future requires all of us to understand the consequences of how we live on where we live - the connection between people and nature. Learning about the true meaning of that connection is a process that starts in early childhood and lasts a lifetime. Blue Sky brings supporters of this work together to learn from one another and to strategize how to scale up the impact of the effective programs that transform how people interact with their surroundings. By making these essential learning opportunities more accessible in all communities, we broaden and strengthen the constituency that makes well-informed choices, balancing the needs of today with the needs of future generations.

  3. Viewing Formal Mathematics from Yoruba Conception of the Sky

    OpenAIRE

    Segla, Aimé

    2016-01-01

    Yoruba Cosmology resembles a generative system at the foundation of concepts. The traditional thought, which derives from the reality of the identical pair incorporated from cosmology into real life, exemplifies all kind of existing knowledge, culture and practices.  Previous studies by the author show in some detail the scientific interests in Yoruba cosmology. The present paper aims to view formal mathematics through the interpretation of Yoruba sky knowledge. It attempts to demonstrate tha...

  4. The sloan digital sky survey-II supernova survey

    DEFF Research Database (Denmark)

    Frieman, Joshua A.; Bassett, Bruce; Becker, Andrew

    2008-01-01

    The Sloan Digital Sky Survey-II (SDSS-II) has embarked on a multi-year project to identify and measure light curves for intermediate-redshift (0.05 < z < 0.35) Type Ia supernovae (SNe Ia) using repeated five-band (ugriz) imaging over an area of 300 sq. deg. The survey region is a stripe 2.5° wide...

  5. The red-sky enigma over Svalbard in December 2002

    Directory of Open Access Journals (Sweden)

    F. Sigernes

    2005-07-01

    Full Text Available On 6 December 2002, during winter darkness, an extraordinary event occurred in the sky, as viewed from Longyearbyen (78° N, 15° E, Svalbard, Norway. At 07:30 UT the southeast sky was surprisingly lit up in a deep red colour. The light increased in intensity and spread out across the sky, and at 10:00 UT the illumination was observed to reach the zenith. The event died out at about 12:30 UT. Spectral measurements from the Auroral Station in Adventdalen confirm that the light was scattered sunlight. Even though the Sun was between 11.8 and 14.6deg below the horizon during the event, the measured intensities of scattered light on the southern horizon from the scanning photometers coincided with the rise and setting of the Sun. Calculations of actual heights, including refraction and atmospheric screening, indicate that the event most likely was scattered solar light from a target below the horizon. This is also confirmed by the OSIRIS instrument on board the Odin satellite. The deduced height profile indicates that the scattering target is located 18–23km up in the stratosphere at a latitude close to 73–75° N, southeast of Longyearbyen. The temperatures in this region were found to be low enough for Polar Stratospheric Clouds (PSC to be formed. The target was also identified as PSC by the LIDAR systems at the Koldewey Station in Ny-Ålesund (79° N, 12° E. The event was most likely caused by solar illuminated type II Polar Stratospheric Clouds that scattered light towards Svalbard. Two types of scenarios are presented to explain how light is scattered. Keywords. Atmospheric composition and structure (Transmissions and scattering of radiation; Middle atmospherecomposition and chemistry; Instruments and techniques – History of geophysics (Atmospheric Sciences; The red-sky phenomena

  6. Piero della Francesca's Sky in The Dream of Constantine

    Science.gov (United States)

    Valerio, V.

    2011-06-01

    The recent restoration of the frescoes by Piero della Francesca in the Church of San Francesco in Arezzo has made to appear on the background of the scene of Constantine's dream a number of stars. They are clearly painted with the intention to illustrate a sort of "natural" sky. In 2001 Anna Maria Maetzke recognized in a group of stars the constellation of the Ursa Minor, but so far no further study has been carried on to find any relation between the painted and the true sky. In this paper I show the existence of more constellations in the fresco, which are hardly detectable due to the mirror representation of the starry sky. Such a mirror image, as the Universe was seen from the outside, has a Greek origin and this kind of representation was introduced in Western Europe not only in celestial globes but also in star maps. This discovery leads to consider that Piero had at his disposal either a globe or a map which he reproduced on the fresco. My hypothesis is that a star map might be supplied to Piero by the astronomer Regiomontanus who was in Italy since 1461 following the Cardinal Bessarion in his journey from Wien to Rome. In 1463, Cardinal Bessarion was named papal legate to Venice and in July of the same year he leaved Rome together with Regiomontanus to reach Ferrara and Venice. The road to Venice crossed Umbria nearby Sansepolcro, Piero's birthplace not far from Arezzo. The trip took more than two weeks due to a stop before crossing the Apennines because the plague in Ferrara. Bessarion and Regiomontanus might have met Piero who was painting the cycle of frescoes in Arezzo and supplied him with a star map. Unfortunately, due to the lack of the horizon and any right line in the scene it is not possible to detect the latitude of the place corresponding to the painted sky.

  7. Advertising Citizen Science: A Trailer for the Citizen Sky Project

    Science.gov (United States)

    Wyatt, Ryan; Price, A.

    2012-01-01

    Citizen Sky is a multi-year, NSF funded citizen science project involving the bright and mysterious variable star epsilon Aurigae. The project was conceived by the IYA 2009 working group on Research Experiences for Students, Teachers, and Citizen-Scientists. Citizen Sky goes beyond simple observing to include a major data analysis component, introducing participants to the full scientific process from background research to paper writing for a peer-reviewed journal. As a means of generating interest in the project, the California Academy of Sciences produced a six-minute "trailer” formatted for both traditional and fulldome planetariums as well as HD and web applications. This talk will review the production process for the trailer as well as the methods of distribution via planetariums, social media, and other venues_along with an update on the Citizen Sky Project as a whole. We will show how to use a small, professionally-produced planetarium trailer to help spread word on a citizen science project. We will also show preliminary results on a study about how participation level/type in the project affects science learning.

  8. Photometric Analysis of Pi of the Sky Data

    Directory of Open Access Journals (Sweden)

    Rafał Opiela

    2013-01-01

    Full Text Available Two fully automatic Pi of the Sky detectors with a large field of view, located in Spain (INTA and in Chile (SPDA observe the sky in search of rare optical phenomena, and also collect observations which include many kinds of variable stars. To be able to draw proper conclusions from the data that is received, adequate quality of the detectors is very important. Pi of the Sky data are subject to systematic errors caused by various factors, e.g. cloud cover seen as significant fluctuations in the number of stars observed by the detector, problems with conducting mounting, a strong background of the moon or the passage of a bright object, e.g. a planet, near the observed star. Some of these adverse effects are already detected during cataloging of the individual measurements, but this is not sufficient to make the quality of the data satisfactory for us. In order to improve the quality of our data, we developed two new procedures based on two different approaches. In this paper we will say some words about these procedures, give some examples, and show how these procedures improve the quality of our data.

  9. Polarization of sky light from a canopy atmosphere

    International Nuclear Information System (INIS)

    Hannay, J H

    2004-01-01

    Light from the clear sky is produced by the scattering of unpolarized sunlight by molecules of the atmosphere and is partially linearly polarized in the process. Singly scattered light, for instance, is fully polarized in viewing directions perpendicular to the sun direction and less and less so towards the parallel and antiparallel directions, where it is unpolarized. The true, multiple, scattering is much less tractable, but importantly different, changing the polarization pattern's topology by splitting the unpolarized directions into pairs. The underlying cause of this 'symmetry breaking' is that the atmosphere is 'wider' than it is deep. Simplifying as much as possible while retaining this feature leads to the caricature atmosphere analysed here: a flattened sheet atmosphere in the sky, a canopy. The multiple scattering is fully tractable and leads to a simple polarization pattern in the sky: the ellipses and hyperbolas of standard confocal ellipsoidal coordinates. The model realizes physically a mathematical pattern of polarization in terms of a complex function proposed by Berry, Dennis and Lee (2004 New J. Phys.6 162) as the simplest one which captures the topology

  10. Mitigation of Volcanic Risk: The COSMO-SkyMed Contribution

    Science.gov (United States)

    Sacco, Patrizia; Daraio, Maria Girolamo; Battagliere, Maria Libera; Coletta, Alessandro

    2015-05-01

    The Italian Space Agency (ASI) promotes Earth Observation (EO) applications related to themes such as the prediction, monitoring, management and mitigation of natural and anthropogenic hazards. The approach generally followed is the development and demonstration of prototype services, using currently available data from space missions, in particular the COSMO-SkyMed (Constellation of Small Satellites for Mediterranean basin observation) mission, which represents the largest Italian investment in Space System for EO and thanks to which Italy plays a key role worldwide. Projects funded by ASI provide the convergence of various national industry expertise, research and institutional reference users. In this context a significant example is represented by the ASI Pilot Projects, recently concluded, dealing with various thematic, such as volcanoes. In this paper a special focus will be addressed to the volcanic risk management and the contribution provided in this field by COSMO-SkyMed satellite constellation during the last years. A comprehensive overview of the various national and international projects using COSMO-SkyMed data for the volcanic risk mitigation will be given, highlighting the Italian contribution provided worldwide in this operational framework.

  11. ATLAS: A High-cadence All-sky Survey System

    Science.gov (United States)

    Tonry, J. L.; Denneau, L.; Heinze, A. N.; Stalder, B.; Smith, K. W.; Smartt, S. J.; Stubbs, C. W.; Weiland, H. J.; Rest, A.

    2018-06-01

    Technology has advanced to the point that it is possible to image the entire sky every night and process the data in real time. The sky is hardly static: many interesting phenomena occur, including variable stationary objects such as stars or QSOs, transient stationary objects such as supernovae or M dwarf flares, and moving objects such as asteroids and the stars themselves. Funded by NASA, we have designed and built a sky survey system for the purpose of finding dangerous near-Earth asteroids (NEAs). This system, the “Asteroid Terrestrial-impact Last Alert System” (ATLAS), has been optimized to produce the best survey capability per unit cost, and therefore is an efficient and competitive system for finding potentially hazardous asteroids (PHAs) but also for tracking variables and finding transients. While carrying out its NASA mission, ATLAS now discovers more bright (m day cadence. ATLAS discovered the afterglow of a gamma-ray burst independent of the high energy trigger and has released a variable star catalog of 5 × 106 sources. This is the first of a series of articles describing ATLAS, devoted to the design and performance of the ATLAS system. Subsequent articles will describe in more detail the software, the survey strategy, ATLAS-derived NEA population statistics, transient detections, and the first data release of variable stars and transient light curves.

  12. The cut-sky cosmic microwave background is not anomalous

    International Nuclear Information System (INIS)

    Pontzen, Andrew; Peiris, Hiranya V.

    2010-01-01

    The observed angular correlation function of the cosmic microwave background has previously been reported to be anomalous, particularly when measured in regions of the sky uncontaminated by Galactic emission. Recent work by Efstathiou et al. presents a Bayesian comparison of isotropic theories, casting doubt on the significance of the purported anomaly. We extend this analysis to all anisotropic Gaussian theories with vanishing mean ( =0), using the much wider class of models to confirm that the anomaly is not likely to point to new physics. On the other hand if there is any new physics to be gleaned, it results from low-l alignments which will be better quantified by a full-sky statistic. We also consider quadratic maximum likelihood power spectrum estimators that are constructed assuming isotropy. The underlying assumptions are therefore false if the ensemble is anisotropic. Nonetheless we demonstrate that, for theories compatible with the observed sky, these estimators (while no longer optimal) remain statistically superior to pseudo-C l power spectrum estimators.

  13. Stellar activity for every TESS star in the Southern sky

    Science.gov (United States)

    Howard, Ward S.; Law, Nicholas; Fors, Octavi; Corbett, Henry T.; Ratzloff, Jeff; del Ser, Daniel

    2018-01-01

    Although TESS will search for Earths around more than 200,000 nearby stars, the life-impacting superflare occurrence of these stars remains poorly characterized. We monitor long-term stellar flare occurrence for every TESS star in the accessible sky at 2-minute cadence with the CTIO-based Evryscope, a combination of twenty-four telescopes, together giving instantaneous sky coverage of 8000 square degrees. In collaboration with Owens Valley Long Wavelength Array (LWA) all-sky monitoring, Evryscope also provides optical counterparts to radio flare, CME, and exoplanet-magnetosphere stellar activity searches. A Northern Evryscope will be installed at Mount Laguna Observatory, CA in collaboration with SDSU later this year, enabling stellar activity characterization for the full TESS target list and both continuous viewing zones, as well as providing 100% overlap with LWA radio activity. Targets of interest (e.g. Proxima Cen, TRAPPIST-1) are given special focus. We are currently sensitive to stellar activity down to 1% precision at g' ~ 10 and about 0.2 of a magnitude at g' ~ 15. With 2-minute cadence and a projected 5-year timeline, with 2+ years already recorded, we present preliminary results from an activity characterization of every Southern TESS target.

  14. Clear-sky narrowband albedos derived from VIRS and MODIS

    Science.gov (United States)

    Sun-Mack, Sunny; Minnis, Patrick; Chen, Yan; Arduini, Robert F.

    2004-02-01

    The Clouds and Earth"s Radiant Energy System (CERES) project is using multispectral imagers, the Visible Infrared Scanner (VIRS) on the tropical Rainfall Measuring Mission (TRMM) satellite and the Moderate Resolution Imaging Spectroradiometer (MODIS) on Terra, operating since spring 2000, and Aqua, operating since summer 2002, to provide cloud and clear-sky properties at various wavelengths. This paper presents the preliminary results of an analysis of the CERES clear-sky reflectances to derive a set top-of-atmosphere clear sky albedo for 0.65, 0.86, 1.6, 2.13 μm, for all major surface types using the combined MODIS and VIRS datasets. The variability of snow albedo with surface type is examined using MODIS data. Snow albedo was found to depend on the vertical structure of the vegetation. At visible wavelengths, it is least for forested areas and greatest for smooth desert and tundra surfaces. At 1.6 and 2.1-μm, the snow albedos are relatively insensitive to the underlying surface because snow decreases the reflectance. Additional analyses using all of the MODIS results will provide albedo models that should be valuable for many remote sensing, simulation and radiation budget studies.

  15. IMPROVED BACKGROUND SUBTRACTION FOR THE SLOAN DIGITAL SKY SURVEY IMAGES

    International Nuclear Information System (INIS)

    Blanton, Michael R.; Kazin, Eyal; Muna, Demitri; Weaver, Benjamin A.; Price-Whelan, Adrian

    2011-01-01

    We describe a procedure for background subtracting Sloan Digital Sky Survey (SDSS) imaging that improves the resulting detection and photometry of large galaxies on the sky. Within each SDSS drift scan run, we mask out detected sources and then fit a smooth function to the variation of the sky background. This procedure has been applied to all SDSS-III Data Release 8 images, and the results are available as part of that data set. We have tested the effect of our background subtraction on the photometry of large galaxies by inserting fake galaxies into the raw pixels, reanalyzing the data, and measuring them after background subtraction. Our technique results in no size-dependent bias in galaxy fluxes up to half-light radii r 50 ∼ 100 arcsec; in contrast, for galaxies of that size the standard SDSS photometric catalog underestimates fluxes by about 1.5 mag. Our results represent a substantial improvement over the standard SDSS catalog results and should form the basis of any analysis of nearby galaxies using the SDSS imaging data.

  16. Variable gamma-ray sky at 1 GeV

    International Nuclear Information System (INIS)

    Pshirkov, M. S.; Rubtsov, G. I.

    2013-01-01

    We search for the long-term variability of the gamma-ray sky in the energy range E > 1 GeV with 168 weeks of the gamma-ray telescope Fermi-LAT data. We perform a full sky blind search for regions with variable flux looking for deviations from uniformity. We bin the sky into 12288 pixels using the HEALPix package and use the Kolmogorov-Smirnov test to compare weekly photon counts in each pixel with the constant flux hypothesis. The weekly exposure of Fermi-LAT for each pixel is calculated with the Fermi-LAT tools. We consider flux variations in a pixel significant if the statistical probability of uniformity is less than 4 × 10 −6 , which corresponds to 0.05 false detections in the whole set. We identified 117 variable sources, 27 of which have not been reported variable before. The sources with previously unidentified variability contain 25 active galactic nuclei (AGN) belonging to the blazar class (11 BL Lacs and 14 FSRQs), one AGN of an uncertain type, and one pulsar PSR J0633+1746 (Geminga).

  17. ACS/WFC Sky Flats from Frontier Fields Imaging

    Science.gov (United States)

    Mack, J.; Lucas, R. A.; Grogin, N. A.; Bohlin, R. C.; Koekemoer, A. M.

    2018-04-01

    Parallel imaging data from the HST Frontier Fields campaign (Lotz et al. 2017) have been used to compute sky flats for the ACS/WFC detector in order to verify the accuracy of the current set of flat field reference files. By masking sources and then co-adding many deep frames, the F606W and F814W filters have enough combined background signal that from Poisson statistics are efficiency tracks the thickness of the two WFC chips. Observations of blue and red calibration standards measured at various positions on the detector (Bohlin et al. 2017) confirm the fidelity of the F814W flat, with aperture photometry consistent to 1% across the FOV, regardless of spectral type. At bluer wavelengths, the total sky background is substantially lower, and the F435W sky flat shows a combination of both flat errors and detector artifacts. Aperture photometry of the red standard star shows a maximum deviation of 1.4% across the array in this filter. Larger residuals up to 2.5% are found for the blue standard, suggesting that the spatial sensitivity in F435W depends on spectral type.

  18. The gamma-ray sky as seen with HAWC

    Science.gov (United States)

    Hüntemeyer, Petra

    2015-12-01

    The High-Altitude Water Cherenkov (HAWC) TeV Gamma-Ray Observatory located at a site about two hours drive east of Puebla, Mexico on the Sierra Negra plateau (4100 m a.s.l.) was inaugurated in March 2015. The array of 300 water Cherenkov detectors can observe large portions of the sky simultaneously and, with an energy range of 100 GeV to 100 TeV, is currently one of the most sensitive instruments capable of probing particle acceleration near PeV energies. HAWC has already started science operation in the Summer of 2013 and preliminary sky maps have been produced from 260 days of data taken with a partial array. Multiple > 5 σ (pre-trials) hotspots are visible along the galactic plane and some appear to coincide with known TeV sources from the H.E.S.S. catalog, SNRs and molecular cloud associations, and pulsars wind nebulae (PWNe). The sky maps based on partial HAWC array data are discussed as well as the scientific potential of the completed instrument especially in the context of multi-wavelengths studies.

  19. The gamma-ray sky as seen with HAWC

    Directory of Open Access Journals (Sweden)

    Hüntemeyer Petra

    2015-01-01

    Full Text Available The High-Altitude Water Cherenkov (HAWC TeV Gamma-Ray Observatory located at a site about two hours drive east of Puebla, Mexico on the Sierra Negra plateau (4100 m a.s.l. was inaugurated in March 2015. The array of 300 water Cherenkov detectors can observe large portions of the sky simultaneously and, with an energy range of 100 GeV to 100 TeV, is currently one of the most sensitive instruments capable of probing particle acceleration near PeV energies. HAWC has already started science operation in the Summer of 2013 and preliminary sky maps have been produced from 260 days of data taken with a partial array. Multiple > 5 σ (pre-trials hotspots are visible along the galactic plane and some appear to coincide with known TeV sources from the H.E.S.S. catalog, SNRs and molecular cloud associations, and pulsars wind nebulae (PWNe. The sky maps based on partial HAWC array data are discussed as well as the scientific potential of the completed instrument especially in the context of multi-wavelengths studies.

  20. All-Sky Interferometry with Spherical Harmonic Transit Telescopes

    Energy Technology Data Exchange (ETDEWEB)

    Shaw, J.Richard [Canadian Inst. Theor. Astrophys.; Sigurdson, Kris [British Columbia U.; Pen, Ue-Li [Canadian Inst. Theor. Astrophys.; Stebbins, Albert [Fermilab; Sitwell, Michael [British Columbia U.

    2013-02-01

    In this paper we describe the spherical harmonic transit telescope, a novel formalism for the analysis of transit radio telescopes. This all-sky approach bypasses the curved sky complications of traditional interferometry and so is particularly well suited to the analysis of wide-field radio interferometers. It enables compact and computationally efficient representations of the data and its statistics that allow new ways of approaching important problems like map-making and foreground removal. In particular, we show how it enables the use of the Karhunen-Loeve transform as a highly effective foreground filter, suppressing realistic foreground residuals for our fiducial example by at least a factor twenty below the 21cm signal even in highly contaminated regions of the sky. This is despite the presence of the angle-frequency mode mixing inherent in real-world instruments with frequency-dependent beams. We show, using Fisher forecasting, that foreground cleaning has little effect on power spectrum constraints compared to hypothetical foreground-free measurements. Beyond providing a natural real-world data analysis framework for 21cm telescopes now under construction and future experiments, this formalism allows accurate power spectrum forecasts to be made that include the interplay of design constraints and realistic experimental systematics with twenty-first century 21cm science.

  1. Determination atmospheric conditions by evaluating clearness index, turbidity and brightness of the sky

    International Nuclear Information System (INIS)

    Kandilli, C.

    2005-01-01

    There are fifteen different sky types which range from totally overcast sky to low turbidity clear sky have been defined by CIE (International Commission on Illumination). For the applications of solar energy engineering and day lighting purposes, it has a great importance to determine the physical characteristics of atmosphere and the sky type. The most important parameters which define the sky type are clearness index, turbidity and brightness. In this study, the parameters of clearness index, turbidity and brightness of the sky belong to Izmir was calculated and their relations with solar radiation and its components were represented according to 10 years data (1994-2004) of meteorology station of Ege University Solar Energy Institute. In this study, clearness index, turbidity, sky clearness and brightness were evaluated to put forward the effects of the these parameters on the atmospheric condition for designing and engineering purposes

  2. ``Dark Skies are a Universal Resource'' Programs Planned for the International Year of Astronomy

    Science.gov (United States)

    Walker, C. E.; Berglund, K.; Bueter, C.; Crelin, B.; Duriscoe, D.; Moore, C.; Gauthier, A.; Gay, P. L.; Foster, T.; Heatherly, S. A.; Maddalena, R.; Mann, T.; Patten, K.; Pompea, S. M.; Sparks, R.; Schaaf, F.; Simmons, M.; Smith, C.; Smith, M.; Tafreshi, B.

    2008-11-01

    In an effort to help more people appreciate the ongoing loss of a dark night sky for much of the world's population and to raise public knowledge about diverse impacts of excess artificial lighting on local environments, the International Year of Astronomy's Dark Skies Working Group has established six ``Dark Skies'' programs and six ``Dark Skies'' resources. The Dark Skies programs include GLOBE at Night (with Earth Hour), Astronomy Nights in the [National] Parks, Dark Skies Discovery Sites, Quiet Skies, Good Neighbor Lighting, and a digital photography contest. Resources include the light education toolkit, the ``Let There Be Night'' DVD and planetarium program, the 6-minute video, online interactions like Second Life, podcasts, and traveling exhibits. The programs and resources are summarized here, as they were in a poster for the June 2008 ASP/AAS conference. For more information on these programs and resources, visit http://astronomy2009.us/darkskies/.

  3. Sky-Radiance Models for Monte Carlo Radiative Transfer Applications

    Science.gov (United States)

    Santos, I.; Dalimonte, D.; Santos, J. P.

    2012-04-01

    Photon-tracing can be initialized through sky-radiance (Lsky) distribution models when executing Monte Carlo simulations for ocean color studies. To be effective, the Lsky model should: 1) properly represent sky-radiance features of interest; 2) require low computing time; and 3) depend on a limited number of input parameters. The present study verifies the satisfiability of these prerequisite by comparing results from different Lsky formulations. Specifically, two Lsky models were considered as reference cases because of their different approach among solutions presented in the literature. The first model, developed by the Harrisson and Coombes (HC), is based on a parametric expression where the sun geometry is the unique input. The HC model is one of the sky-radiance analytical distribution applied in state-of-art simulations for ocean optics. The coefficients of the HC model were set upon broad-band field measurements and the result is a model that requires a few implementation steps. The second model, implemented by Zibordi and Voss (ZV), is based on physical expressions that accounts for the optical thickness of permanent gases, aerosol, ozone and water vapour at specific wavelengths. Inter-comparisons between normalized ^LskyZV and ^LskyHC (i.e., with unitary scalar irradiance) are discussed by means of individual polar maps and percent difference between sky-radiance distributions. Sky-radiance cross-sections are presented as well. Considered cases include different sun zenith values and wavelengths (i.e., λ=413, 490 and 665 nm, corresponding to selected center-bands of the MEdium Resolution Imaging Spectrometer MERIS). Results have shown a significant convergence between ^LskyHC and ^LskyZV at 665 nm. Differences between models increase with the sun zenith and mostly with wavelength. For Instance, relative differences up to 50% between ^ L skyHC and ^ LskyZV can be observed in the antisolar region for λ=665 nm and θ*=45°. The effects of these

  4. Introduction to the Arizona Sky Island Arthropod Project (ASAP): Systematics, biogeography, ecology, and population genetics of arthropods of the Madrean Sky Islands

    Science.gov (United States)

    Wendy Moore; Wallace M. Meyer; Jeffrey A. Eble; Kimberly Franklin; John F. Wiens; Richard C. Brusca

    2013-01-01

    The Arizona Sky Island Arthropod Project (ASAP) is a new multi-disciplinary research program at the University of Arizona that combines systematics, biogeography, ecology, and population genetics to study origins and patterns of arthropod diversity along elevation gradients and among mountain ranges in the Madrean Sky Island Region. Arthropods represent taxonomically...

  5. Simultaneous measurement of spectral sky radiance by a non-scanning multidirectional spectroradiometer (MUDIS)

    International Nuclear Information System (INIS)

    Riechelmann, Stefan; Schrempf, Michael; Seckmeyer, Gunther

    2013-01-01

    We present a novel non-scanning multidirectional spectroradiometer (MUDIS) measuring the spectral sky radiance as a function of zenith and azimuth angle with a high spectral and temporal resolution. The instrument is based on a hyperspectral imager and measures spectral sky radiance in the wavelength range of 250–600 nm at 113 different directions simultaneously. MUDIS has been intercalibrated with a sky scanning CCD spectroradiometer (SCCD). Sky radiance measurements have been performed with both instruments under cloudless and overcast sky. The spectral actinic irradiance derived from those measurements agrees within 8% for wavelengths higher than 320 nm. The bias between synchronous MUDIS and SCCD sky radiance measurements during cloudless and overcast sky is below 5% for 320 and 500 nm with a 1σ standard deviation of less than 10%. MUDIS enables us to perform more than 220 000 spectral sky radiance measurements instead of approximately 6000 SCCD spectral sky radiance measurements per day and to measure spatial variations of spectral sky radiance simultaneously. (paper)

  6. A lobster-eye on the x-ray sky

    International Nuclear Information System (INIS)

    Peele, A. G.; Zhang, W.; Gendreau, K. C.; Petre, R.; White, N. E.

    1999-01-01

    We propose an x-ray all-sky monitor for the International Space Station (ISS) that will be ten times more sensitive than past monitors and that opens up a new band of the soft x-ray spectrum (0.1 -3.0 keV) for study. Taking advantage of the power telemetry and space available on the ISS we can use a telescope geometry and detectors that will provide better than 4 arc minute resolution of the entire sky in a 1.5 hr duty cycle. To achieve this sensitivity and resolution we use focusing optics based on the lobster-eye geometry. We propose two approaches to the construction of the optics. The first method, well within the reach of existing technology, is to approximate the lobster-eye geometry by building crossed arrays of planar reflectors, this gives great control over the reflecting surface but is limited in terms of resolution at the baseline 4 arc minute level. The second method is to use microchannel plates: this technology has the potential to greatly exceed the baseline resolution and sensitivity but is yet to be fully demonstrated. A simultaneous development of both approaches with selection of the superior candidate at the end of the development phase is suggested. The instrument is made of a number of modules based on a 2x2 cooled CCD detector array that covers an area of 6x6 cm 2 at the focal plane. Using optics with a radius of curvature of 0.75 m this gives each module a field of view of 9 deg. x 9 deg. The modular approach gives us enormous flexibility in terms of physical arrangement on the ISS so that we may take advantage of clear lines of sight and also in terms of built-in redundancy. We estimate that ∼50 such modules give us instantaneous coverage of 1/10 of the sky. The scientific case for this mission is almost too broad to state here. The instrument we describe will allow investigation of the long term light curves of thousands of AGN, it will detect thousands of transients, including GRBs and type II supernova, and the stellar coronae of

  7. Recent Advances and Achievements at The Catalina Sky Survey

    Science.gov (United States)

    Leonard, Gregory J.; Christensen, Eric J.; Fuls, Carson; Gibbs, Alex; Grauer, Al; Johnson, Jess A.; Kowalski, Richard; Larson, Stephen M.; Matheny, Rose; Seaman, Rob; Shelly, Frank

    2017-10-01

    The Catalina Sky Survey (CSS) is a NASA-funded project fully dedicated to discover and track near-Earth objects (NEOs). Since its founding nearly 20 years ago CSS remains at the forefront of NEO surveys, and recent improvements in both instrumentation and software have increased both survey productivity and data quality. In 2016 new large-format (10K x 10K) cameras were installed on both CSS survey telescopes, the 1.5-m reflector and the 0.7-m Schmidt, increasing the field of view, and hence nightly sky coverage by 4x and 2.4x respectively. The new cameras, coupled with improvements in the reduction and detection pipelines, and revised sky-coverage strategies have yielded a dramatic upward trend of NEO discovery rates. CSS has also developed a custom adaptive queue manager for scheduling NEO follow-up astrometry using a remotely operated and recently renovated 1-m Cassegrain reflector telescope, improvements that have increased the production of follow-up astrometry for newly discovered NEOs and arc extensions for previously discovered objects by CSS and other surveys. Additionally, reprocessing of archival CSS data (which includes some 46 million individual astrometric measurements) through the new reduction and detection pipeline will allow for improved orbit determinations and increased arc extensions for hundreds of thousands of asteroids. Reprocessed data will soon feed into a new public archive of CSS images and catalog data products made available through NASA’s Planetary Data System (PDS). For the future, CSS is working towards improved NEO follow-up capabilities through a combination of access to larger telescopes, instrument upgrades and follow-up scheduling tools.

  8. Traces on sky. Unexpected results of regular observations

    Science.gov (United States)

    Churyumov, K. I.; Steklov, A. F.; Vidmachenko, A. P.; Dashkiev, N. G.; Steklov, E. A.

    2016-08-01

    If the fireball's track has noticeable angular size, it can be seen even in the daytime. After the flight, bolide remains a noticeable trace of a dust, dark against the light sky. If such a dust trail illuminated by the rays of the Sun, which had just hid behind the horizon (or even in the moonlight), it is visible as bright lanes in the night sky or in twilight. That's why we call it the twilight bolides. Usually, astronomical observations using of meteor patrols, carried out at night after the evening astronomical twilight. But from March 2013 to October 2015, the authors have obtained several thousands of different tracks in the sky over Kiev. Therefore, we have identified a special class of twilight observations of fireballs. We register the traces of invading to atmosphere of meteoroids of natural and artificial origin. At the same time, observe the traces of fireballs at the day-time are also possible. But they are less effective than in the twilight. Night observations of bright meteoric tracks can usually observe some seconds. While traces of the twilight bolides we observed from some minutes up to two hours, before they be scattered by atmospheric currents. It opens the great prospects for low-cost direct experiments probing of these tracks by using, for example, the astronomical aviation. We propose the twilight tracks are classified into the following types: AMT - aero-meteorological tracks, AST - aero-space, ATT - aero-technical, and NST - not yet classified tracks of unknown nature. During the short period of our observations (from March 2013 to 2016), was fixed falling at least a dozen fragments of cometary nuclei, at least five of sufficiently large and dozens of smaller fragments of meteoroids. The results of our observations also showed that during the morning and evening twilight over Kiev clearly visible the plume of aerosols of technical nature from the plants, factories and other production facilities.

  9. Imaging microchannel plate detectors for XUV sky survey experiments

    International Nuclear Information System (INIS)

    Barstow, M.A.; Fraser, G.W.; Milward, S.R.

    1986-01-01

    Attention is given to the development of microchannel plate detectors for the Wide Field Camera (WFC) XUV (50-300 A) sky survey experiment on Rosat. A novel feature of the detector design is that the microchannel plates and their resistive anode readout are curved to the same radius as the WFC telescope focal surface. It is shown that curving the channel plates is not detrimental to gain uniformity. The paper describes the design of a curved resistive anode readout element and contrasts the present measurements of spatial resolution, global and local uniformity and temperature coefficient of resistance with the poor performance recently ascribed to resistive anodes in the literature. 18 references

  10. SCExAO: First Results and On-Sky Performance

    Science.gov (United States)

    Currie, Thayne; Guyon, Olivier; Martinache, Frantz; Clergeon, Christophe; McElwain, Michael; Thalmann, Christian; Jovanovic, Nemanja; Singh, Garima; Kudo, Tomoyuki

    2013-01-01

    We present new on-sky results for the Subaru Coronagraphic Extreme Adaptive Optics imager (SCExAO) verifying and quantifying the contrast gain enabled by key components: the closed-loop coronagraphic low-order wavefront sensor (CLOWFS) and focal plane wavefront control ("speckle nulling"). SCExAO will soon be coupled with a high-order, Pyramid wavefront sensor which will yield greater than 90% Strehl ratio and enable 10(exp 6) -10(exp 7) contrast at small angular separations allowing us to image gas giant planets at solar system scales. Upcoming instruments like VAMPIRES, FIRST, and CHARIS will expand SCExAO's science capabilities.

  11. EoR Foregrounds: the Faint Extragalactic Radio Sky

    Science.gov (United States)

    Prandoni, Isabella

    2018-05-01

    A wealth of new data from upgraded and new radio interferometers are rapidly improving and transforming our understanding of the faint extra-galactic radio sky. Indeed the mounting statistics at sub-mJy and μJy flux levels is finally allowing us to get stringent observational constraints on the faint radio population and on the modeling of its various components. In this paper I will provide a brief overview of the latest results in areas that are potentially important for an accurate treatment of extra-galactic foregrounds in experiments designed to probe the Epoch of Reionization.

  12. Determining Light Pollution of the Global Sky: GLOBE at Night

    Science.gov (United States)

    Henderson, S.; Meymaris, K.; Ward, D.; Walker, C.; Russell, R.; Pompea, S.; Salisbury, D.

    2006-05-01

    GLOBE at Night is an international science event designed to observe and record the visible stars as a means of measuring light pollution in a given location. Increased and robust understanding of our environment requires learning opportunities that take place outside of the conventional K-12 classroom and beyond the confines of the school day. This hands-on learning activity extended the traditional classroom and school day last March with a week of nighttime sky observations involving teachers, students and their families. The quality of the night sky for stellar observations is impacted by several factors including human activities. By observing cloud cover and locating specific constellations in the sky, students from around the world learned how the lights in their community contribute to light pollution, exploring the relationship between science, technology and their society. Students learned that light pollution impacts more than just the visibility of stars at night. Lights at night impact both the biology and ecology of many species in our environment. Students were able to participate in this global scientific campaign by submitting their observations through an online database, allowing for authentic worldwide research and analysis by participating scientists. Students and their families learned how latitude and longitude coordinates provide a location system to map and analyze the observation data submitted from around the globe. The collected data is available online for use by students, teachers and scientists worldwide to assess how the quality of the night sky varies around the world. This session will share how students and scientists across the globe can explore and analyze the results of this exciting campaign. GLOBE at Night is a collaborative effort sponsored by The GLOBE Program, the National Optical Astronomy Observatory (NOAO), Centro de Apoyo a la Didactica de la Astronomia (CADIAS), Windows to the Universe, and ESRI. The GLOBE Program is

  13. The Sondrestrom Research Facility All-sky Imagers

    Science.gov (United States)

    Kendall, E. A.; Grill, M.; Gudmundsson, E.; Stromme, A.

    2010-12-01

    The Sondrestrom Upper Atmospheric Research Facility is located near Kangerlussuaq, Greenland, just north of the Arctic Circle and 100 km inland from the west coast of Greenland. The facility is operated by SRI International in Menlo Park, California, under the auspices of the U.S. National Science Foundation. Operating in Greenland since 1983, the Sondrestrom facility is host to more than 20 instruments, the majority of which provide unique and complementary information about the arctic upper atmosphere. Together these instruments advance our knowledge of upper atmospheric physics and determine how the tenuous neutral gas interacts with the charged space plasma environment. The suite of instrumentation supports many disciplines of research - from plate tectonics to auroral physics and space weather. The Sondrestrom facility has recently acquired two new all-sky imagers. In this paper, we present images from both new imagers, placing them in context with other instruments at the site and detailing to the community how to gain access to this new data set. The first new camera replaces the intensified auroral system which has been on site for nearly three decades. This new all-sky imager (ASI), designed and assembled by Keo Scientific Ltd., employs a medium format 180° fisheye lens coupled to a set of five 3-inch narrowband interference filters. The current filter suite allows operation at the following wavelengths: 750 nm, 557.7 nm, 777.4 nm, 630.0 nm, and 732/3 nm. Monochromatic images from the ASI are acquired at a specific filter and integration time as determined by a unique configuration file. Integrations as short as 0.5 sec can be commanded for exceptionally bright features. Preview images are posted to the internet in near real-time, with final images posted weeks later. While images are continuously collected in a "patrol mode," users can request special collection sequences for targeted experiments. The second new imager installed at the Sondrestrom

  14. Eyes on the Skies 400 Years of Telescopic Discovery

    CERN Document Server

    Schilling, Govert

    2011-01-01

    Adopted as the official book of the International Year of Astronomy (IYA) 2009, this stunningly illustrated history of telescopic discovery spans the range from the first telescopes via the Hubble Space Telescope to next generation platforms, and how they have changed and continue to change our view of the universe, our place in it and where it all came from. Eyes on the Skies features numerous full-page photographs and is printed in high-quality color throughout. Also includes the official IYA DVD with 59 minutes of narrated text, expert comments and interviews, animations, computer simulatio

  15. The WATCH All-Sky Monitor for the Granat Project

    DEFF Research Database (Denmark)

    Brandt, Søren; Lund, Niels; Rao, A. R.

    1990-01-01

    The Watch X-ray all-sky monitor, which is designed to localize strong X-ray sources and follow their development, is examined, focusing on the addition of four Watch units to the Granat satellite project. The components of the Watch instrument are described and the capabilities and potential...... scientific returns of the Granat project are discussed. The applications of the Watch monitor are given, including the study of time variations of known sources and the detection and localization of new, transient sources....

  16. Observation of GEO Satellite Above Thailand’s Sky

    Science.gov (United States)

    Kasonsuwan, K.; Wannawichian, S.; Kirdkao, T.

    2017-09-01

    The direct observations of Geostationary Orbit (GEO) satellites above Thailand’s sky by 0.7-meters telescope were proceeded at Inthanon Mt., Chiang Mai, Thailand. The observation took place at night with Sidereal Stare Mode (SSM). With this observing mode, the moving object will appear as a streak. The star identification for image calibration is based on (1) a star catalogue, (2) the streak detection of the satellite using the software and (3) the extraction of the celestial coordinate of the satellite as a predicted position. Finally, the orbital elements for GEO satellites were calculated.

  17. The VLA Sky Survey (VLASS): Overview and First Results

    Science.gov (United States)

    Myers, Steven T.; VLASS Survey Team, Survey Science Group (SSG)

    2018-01-01

    The VLA Sky Survey (VLASS) is a 5520 hour spectropolarimetric synoptic survey covering the 33885 square degrees of the sky above Declination -40 degrees from 2-4 GHz at 2.5" angular resolution using the upgraded Karl G. Jansky Very Large Array (VLA). Over the survey duration of 7 years, each area of the sky will be covered in 3 epochs spaced 32 months apart, to a projected depth of 0.12mJy/beam rms noise per epoch and 0.07mJy/beam for 3 epochs combined. The VLASS employs on-the-fly mosaicking (OTFM) to rapidly scan the sky with a net speed of approximately 20 sq. degrees per hour. The high-level science goals for the survey include the identification and precise location of radio transients, the measurement of magnetic fields in our galaxy and beyond, and the study of radio emission from galaxies and active galactic nuclei throughout the Universe. The ability of the VLASS to see through dust allows us to unveil phenomena such as hidden cosmic explosions, emission from deep within our galaxy, and supermassive black holes buried within host galaxies.The VLASS was proposed in 2014 by our community-led Survey Science Group (SSG). VLASS Pilot observations were taken in mid-2016, and the first epoch covering half the area (VLASS1.1) commenced in September 2017. The raw data from the VLASS are available in the NRAO archive immediately with no proprietary period. The Basic Data Products (BDP) that will be produced by the survey team are public and will additionally include: calibrated visibility data, quick-look continuum images (with a goal of posting to the archive within 1 week of observation), single-epoch and cumulative combined-epoch images, spectral image cubes, and basic object catalogs. Single-epoch and cumulative images are in intensity and linear polarization (Stokes IQU). In addition to the BDP provided by NRAO and served through the NRAO archive, there are plans for Enhanced Data Products and Services to be provided by the community in partnership with the

  18. The Einstein All-Sky IPC slew survey

    Science.gov (United States)

    Elvis, Martin; Plummer, David; Fabbiano, G.

    1989-01-01

    The construction of the Einstein All-Sky Imaging Proportional Counter (IPC) slew survey is considered. It contains approximately 1000 sources between 10(exp -12) and 10(exp -10) erg/sq cm/s with a concentration toward the ecliptic poles and away from the galactic plane. Several sizable samples of bright soft X-ray selected objects for follow-up ROSAT and ASTRO-D observations and statistical study are presented. The survey source list is expected to be available by late 1989. Both paper and remote access online data base versions are to be available. An identification program is considered.

  19. Echoes of the ancient skies the astronomy of lost civilizations

    CERN Document Server

    Krupp, E C

    2003-01-01

    ""It should be read by anyone even remotely interested in the long saga of the universe's profound and lasting influence on mankind's development."" - New Scientist""A grand book."" - Publishers Weekly""Dr. Krupp teaches us once more to look up at the stars and marvel."" - Ray BradburyThe intriguing world of archaeoastronomy - the study of ancient peoples' observations of the skies and the impact of what they saw on their cultural evolution - is the focus of this eminently readable and authoritative survey. Author E. C. Krupp, an astronomer, is the director of the Griffith Observatory in Los

  20. Multichannel interactions in the (1σ/sub g/)2(1σ/sub u/)nsσ, ndλ(3Σ+/sub u/,3Σ+/sub u/,3Pi/sub u/,3Δ/sub u/) Rydberg structures of He2

    International Nuclear Information System (INIS)

    Ginter, D.S.; Ginter, M.L.

    1988-01-01

    We show that a minimal parameter coupled channel model based on eigenquantum defect theory can reproduce quantitatively the known Rydberg structures associated with six channels of nsσ,ndλ( 3 Σ + /sub u/, 3 Σ + /sub u/, 3 Pi/sub u/, 3 Δ/sub u/) v = 0 ancestry in He 2 . Except for a few levels affected by accidental perturbations, these extensive level structures can be reproduced to within average experimental uncertainties. Previously unreported spectral analyses for transitions to the b 3 Pi/sub g/ state from rotational levels in the nl channel segments with n = 12--18 are included in this work. These spectral transitions were predicted and observed in the early stages of this investigation and were used to determine a number of new energy levels for the n = 3--18 data base used in subsequent calculations. The model uses a U matrix modified slightly from a Hund's case (b) to case (d) transformation and energy dependent eigenquantum defects μ/sub α/. Discussed in detail is a specific 14 parameter representation for ∼500 energy levels in which 2 parameters modify U to include interactions between ns and nd and 12 parameters describe the variation of the μ/sub α/'s with energy

  1. SKY BRIGHTNESS AND TRANSPARENCY IN THE i-BAND AT DOME A, ANTARCTICA

    International Nuclear Information System (INIS)

    Zou Hu; Zhou Xu; Jiang Zhaoji; Hu Jingyao; Ma Jun; Ashley, M. C. B.; Luong-Van, D. M.; Storey, J. W. V.; Cui Xiangqun; Feng Longlong; Gong Xuefei; Kulesa, C. A.; Lawrence, J. S.; Liu Genrong; Moore, A. M.; Pennypacker, C. R.; Travouillon, T.; Qin Weijia; Sun Bo; Shang Zhaohui

    2010-01-01

    The i-band observing conditions at Dome A on the Antarctic plateau have been investigated using data acquired during 2008 with the Chinese Small Telescope Array. The sky brightness, variations in atmospheric transparency, cloud cover, and the presence of aurorae are obtained from these images. The median sky brightness of moonless clear nights is 20.5 mag arcsec -2 in the SDSS i band at the south celestial pole (which includes a contribution of about 0.06 mag from diffuse Galactic light). The median over all Moon phases in the Antarctic winter is about 19.8 mag arcsec -2 . There were no thick clouds in 2008. We model contributions of the Sun and the Moon to the sky background to obtain the relationship between the sky brightness and transparency. Aurorae are identified by comparing the observed sky brightness to the sky brightness expected from this model. About 2% of the images are affected by relatively strong aurorae.

  2. Measuring high-resolution sky luminance distributions with a CCD camera.

    Science.gov (United States)

    Tohsing, Korntip; Schrempf, Michael; Riechelmann, Stefan; Schilke, Holger; Seckmeyer, Gunther

    2013-03-10

    We describe how sky luminance can be derived from a newly developed hemispherical sky imager (HSI) system. The system contains a commercial compact charge coupled device (CCD) camera equipped with a fish-eye lens. The projection of the camera system has been found to be nearly equidistant. The luminance from the high dynamic range images has been calculated and then validated with luminance data measured by a CCD array spectroradiometer. The deviation between both datasets is less than 10% for cloudless and completely overcast skies, and differs by no more than 20% for all sky conditions. The global illuminance derived from the HSI pictures deviates by less than 5% and 20% under cloudless and cloudy skies for solar zenith angles less than 80°, respectively. This system is therefore capable of measuring sky luminance with the high spatial and temporal resolution of more than a million pixels and every 20 s respectively.

  3. Weather and atmosphere observation with the ATOM all-sky camera

    Directory of Open Access Journals (Sweden)

    Jankowsky Felix

    2015-01-01

    Full Text Available The Automatic Telescope for Optical Monitoring (ATOM for H.E.S.S. is an 75 cm optical telescope which operates fully automated. As there is no observer present during observation, an auxiliary all-sky camera serves as weather monitoring system. This device takes an all-sky image of the whole sky every three minutes. The gathered data then undergoes live-analysis by performing astrometric comparison with a theoretical night sky model, interpreting the absence of stars as cloud coverage. The sky monitor also serves as tool for a meteorological analysis of the observation site of the the upcoming Cherenkov Telescope Array. This overview covers design and benefits of the all-sky camera and additionally gives an introduction into current efforts to integrate the device into the atmosphere analysis programme of H.E.S.S.

  4. Daylighting on the working plane in oriented attic rooms under overcast and clear sky

    Directory of Open Access Journals (Sweden)

    Kondáš Kristián

    2014-06-01

    Full Text Available The evaluation of daylight conditions in building interiors is based on the Daylight Factor concept after current Slovak standards. Criteria and requirements determined in these standards consider the worst daylight exterior conditions which are described by CIE overcast sky model. The sky luminance distribution of overcast sky is centrical to the zenith, so independence of window orientation to cardinal points is characteristic in daylighting calculations. The sky luminance distribution modelling is one of the main task of the daylight source research more than 50 years. It is evident that also other types of sky conditions exist in nature. An introduction of a new criterion based on photometric variables, which also consider sunlight influence, is expected. This article represents a study of the influence of the interior orientation on distribution of daylighting in attic spaces under an overcast and clear sky

  5. LoFASM: A Low Frequency All Sky Monitor for Radio Transients and Student Training

    Science.gov (United States)

    2015-09-02

    SECURITY CLASSIFICATION OF: The Low-Frequency All- Sky Monitor (LoFASM) is an innovative new radio astronomy observatory. Designed and built by...Feb-2015 Approved for Public Release; Distribution Unlimited Final Report: LoFASM: A Low Frequency All Sky Monitor for Radio Transients and Student...reviewed journals: Number of Papers published in non peer-reviewed journals: Final Report: LoFASM: A Low Frequency All Sky Monitor for Radio Transients and

  6. Spatiotemporal change of sky polarization during the total solar eclipse on 29 March 2006 in Turkey: polarization patterns of the eclipsed sky observed by full-sky imaging polarimetry.

    Science.gov (United States)

    Sipocz, Brigitta; Hegedüs, Ramón; Kriska, György; Horváth, Gábor

    2008-12-01

    Using 180 degrees field-of-view (full-sky) imaging polarimetry, we measured the spatiotemporal change of the polarization of skylight during the total solar eclipse on 29 March 2006 in Turkey. We present our observations here on the temporal variation of the celestial patterns of the degree p and angle alpha of linear polarization of the eclipsed sky measured in the red (650 nm), green (550 nm), and blue (450 nm) parts of the spectrum. We also report on the temporal and spectral change of the positions of neutral (unpolarized, p = 0) points, and points with local minima or maxima of p of the eclipsed sky. Our results are compared with the observations performed by the same polarimetric technique during the total solar eclipse on 11 August 1999 in Hungary. Practically the same characteristics of celestial polarization were encountered during both eclipses. This shows that the observed polarization phenomena of the eclipsed sky may be general.

  7. X-RAY-EMITTING STARS IDENTIFIED FROM THE ROSAT ALL-SKY SURVEY AND THE SLOAN DIGITAL SKY SURVEY

    International Nuclear Information System (INIS)

    Agueeros, Marcel A.; Newsom, Emily R.; Anderson, Scott F.; Hawley, Suzanne L.; Silvestri, Nicole M.; Szkody, Paula; Covey, Kevin R.; Posselt, Bettina; Margon, Bruce; Voges, Wolfgang

    2009-01-01

    The ROSAT All-Sky Survey (RASS) was the first imaging X-ray survey of the entire sky. Combining the RASS Bright and Faint Source Catalogs yields an average of about three X-ray sources per square degree. However, while X-ray source counterparts are known to range from distant quasars to nearby M dwarfs, the RASS data alone are often insufficient to determine the nature of an X-ray source. As a result, large-scale follow-up programs are required to construct samples of known X-ray emitters. We use optical data produced by the Sloan Digital Sky Survey (SDSS) to identify 709 stellar X-ray emitters cataloged in the RASS and falling within the SDSS Data Release 1 footprint. Most of these are bright stars with coronal X-ray emission unsuitable for SDSS spectroscopy, which is designed for fainter objects (g > 15 [mag]). Instead, we use SDSS photometry, correlations with the Two Micron All Sky Survey and other catalogs, and spectroscopy from the Apache Point Observatory 3.5 m telescope to identify these stellar X-ray counterparts. Our sample of 707 X-ray-emitting F, G, K, and M stars is one of the largest X-ray-selected samples of such stars. We derive distances to these stars using photometric parallax relations appropriate for dwarfs on the main sequence, and use these distances to calculate L X . We also identify a previously unknown cataclysmic variable (CV) as a RASS counterpart. Separately, we use correlations of the RASS and the SDSS spectroscopic catalogs of CVs and white dwarfs (WDs) to study the properties of these rarer X-ray-emitting stars. We examine the relationship between (f X /f g ) and the equivalent width of the Hβ emission line for 46 X-ray-emitting CVs and discuss tentative classifications for a subset based on these quantities. We identify 17 new X-ray-emitting DA (hydrogen) WDs, of which three are newly identified WDs. We report on follow-up observations of three candidate cool X-ray-emitting WDs (one DA and two DB (helium) WDs); we have not

  8. Derivation of Sky-View Factors from LIDAR Data

    Science.gov (United States)

    Kidd, Christopher; Chapman, Lee

    2013-01-01

    The use of Lidar (Light Detection and Ranging), an active light-emitting instrument, is becoming increasingly common for a range of potential applications. Its ability to provide fine resolution spatial and vertical resolution elevation data makes it ideal for a wide range of studies. This paper demonstrates the capability of Lidar data to measure sky view factors (SVF). The Lidar data is used to generate a spatial map of SVFs which are then compared against photographically-derived SVF at selected point locations. At each location three near-surface elevations measurements were taken and compared with collocated Lidar-derived estimated. It was found that there was generally good agreement between the two methodologies, although with decreasing SVF the Lidar-derived technique tended to overestimate the SVF: this can be attributed in part to the spatial resolution of the Lidar sampling. Nevertheless, airborne Lidar systems can map sky view factors over a large area easily, improving the utility of such data in atmospheric and meteorological models.

  9. Passive unmanned sky spectroscopy for remote bird classification

    Science.gov (United States)

    Lundin, Patrik; Brydegaard, Mikkel; Cocola, Lorenzo; Runemark, Anna; Åkesson, Susanne; Svanberg, Sune

    2011-11-01

    We present a method based on passive spectroscopy with aim to remotely study flying birds. A compact spectrometer is continuously recording spectra of a small section of the sky, waiting for birds to obscure part of the field-of-view when they pass the field in flight. In such situations the total light intensity received through the telescope, looking straight up, will change very rapidly as compared to the otherwise slowly varying sky light. On passage of a bird, both the total intensity and the spectral shape of the captured light changes notably. A camera aimed in the same direction as the telescope, although with a wider field-of-view, is triggered by the sudden intensity changes in the spectrometer to record additional information, which may be used for studies of migration and orientation. Example results from a trial are presented and discussed. The study is meant to explore the information that could be gathered and extracted with the help of a spectrometer connected to a telescope. Information regarding the color, size and height of flying birds is discussed. Specifically, an application for passive distance determination utilizing the atmospheric oxygen A-band absorption at around 760 nm is discussed.

  10. Dusty WDs in the WISE all sky survey ∩ SDSS

    Energy Technology Data Exchange (ETDEWEB)

    Barber, Sara D.; Kilic, Mukremin; Gianninas, A. [Homer L. Dodge Department of Physics and Astronomy, University of Oklahoma, 440 W. Brooks St., Norman, OK 73019 (United States); Brown, Warren R., E-mail: barber@nhn.ou.edu [Smithsonian Astrophysical Observatory, 60 Garden Street, Cambridge, MA 02138 (United States)

    2014-05-10

    A recent cross-correlation between the Sloan Digital Sky Survey (SDSS) Data Release 7 White Dwarf Catalog with the Wide-Field Infrared Survey Explorer (WISE) all-sky photometry at 3.4, 4.6, 12, and 22 μm performed by Debes et al. resulted in the discovery of 52 candidate dusty white dwarfs (WDs). However, the 6'' WISE beam allows for the possibility that many of the excesses exhibited by these WDs may be due to contamination from a nearby source. We present MMT+SAO Wide-Field InfraRed Camera J- and H-band imaging observations (0.''5-1.''5 point spread function) of 16 of these candidate dusty WDs and confirm that four have spectral energy distributions (SEDs) consistent with a dusty disk and are not accompanied by a nearby source contaminant. The remaining 12 WDs have contaminated WISE photometry and SEDs inconsistent with a dusty disk when the contaminating sources are not included in the photometry measurements. We find the frequency of disks around single WDs in the WISE ∩ SDSS sample to be 2.6%-4.1%. One of the four new dusty WDs has a mass of 1.04 M {sub ☉} (progenitor mass 5.4 M {sub ☉}) and its discovery offers the first confirmation that massive WDs (and their massive progenitor stars) host planetary systems.

  11. Surveying the skies how astronomers map the universe

    CERN Document Server

    Wynn-Williams, Gareth

    2016-01-01

    Since the time of Galileo, astronomy has been driven by technological innovation. With each major advance has come the opportunity and enthusiasm to survey the sky in a way that was not possible before. It is these surveys of discovery that are the subject of this book. In the first few chapters the author discusses what astronomers learned from visible-light surveys, first with the naked eye, then using telescopes in the seventeenth century, and photography in the nineteenth century. He then moves to the second half of the twentieth century when the skies started to be swept by radio, infrared, ultraviolet, x-ray and gamma ray telescopes, many of which had to be flown in satellites above the Earth’s atmosphere. These surveys led to the discovery of pulsars, quasars, molecular clouds, protostars, bursters, and black holes. He then returns to Earth to describe several currently active large-scale projects that methodically collect images, photometry and spectra that are then stored in vast publicly-accessibl...

  12. Enhanced solar global irradiance during cloudy sky conditions

    Energy Technology Data Exchange (ETDEWEB)

    Schade, N.H.; Sandmann, H.; Stick, C. [Kiel Univ. (Germany). Inst. fuer Medizinische Klimatologie; Macke, A. [Kiel Univ. (DE). Leibniz Inst. fuer Meereswissenschaften (IFM-GEOMAR)

    2007-06-15

    The impact of cloudiness on the shortwave downwelling radiation (SDR) at the surface is investigated by means of collocated pyranometer radiation measurements and all-sky imager observations. The measurements have been performed in Westerland, a seaside resort on the North Sea island of Sylt, Germany, during summer 2004 and 2005. A main improvement to previous studies on this subject resulted from the very high temporal resolution of cloud images and radiation measurements and, therefore, a more robust statistical analysis of the occurrence of this effect. It was possible to observe an excess of solar irradiation compared to clear sky irradiation by more than 500 W/m{sup 2}, the largest observed excess irradiation to our knowledge so far. Camera images reveal that largest excess radiation is reached close to overcast situations with altocumulus clouds partly obscuring the solar disk, and preferably with cumulus clouds in lower levels. The maximum duration of the enhancements depends on its strength and ranges from 20 seconds (enhancements > 400 W/m{sup 2}) up to 140 seconds (enhancements > 200 W/m{sup 2}). (orig.)

  13. The Second Data Release of the Sloan Digital Sky Survey

    CERN Document Server

    Abazajian, Kevork; ̈ueros, Marcel A. Ag; Allam, Sahar S.; Anderson, KurtS. J.; Anderson, Scott F.; Annis, James; Bahcall, Neta A.; Baldry, Ivan K.; StevenBastian; Berlind, Andreas; Bernardi, Mariangela; Blanton, Michael R.; BochanskiJr., John J.; Boroski, William N.; Briggs, John W.; Brinkmann, J.; Brunner, Robert J.; ́ari, Tam ́asBudav; Carey, Larry N.; Carliles, Samuel; Castander, Francisco J.; Connolly, A. J.; Csabai, Istvan; Doi, Mamoru; Dong, Feng; Eisenstein, Daniel J.; Evans, Michael L.; Fan, Xiaohui; Finkbeiner, Douglas P.; Friedman, Scott D.; Frieman, Joshua A.; Fukugita, Masataka; Gal, RoyR.; Gillespie, Bruce; Glazebrook, Karl; Gray, Jim; Grebel, Eva K.; Gunn, James E.; Gurbani, Vijay K.; Hall, Patrick B.; Hamabe, Masaru; Harris, Frederick H.; C.Harris, Hugh; Harvanek, Michael; Heckman, Timothy M.; Hendry, John S.; Hennessy, Gregory S.; Hindsley, Robert B.; Hogan, Craig J.; Hogg, David W.; Holmgren, Donald J.; Ichikawa, Shin-ichi; Ichikawa, Takashi; Ivezic, Zeljko; Jester, Sebastian; Johnston, David E.; Jorgensen, AndersM.; Kent, Stephen M.; Kleinman, S. J.; Knapp, G. R.; Kniazev, Alexei Yu.; Kron, Richard G.; Krzesinski, Jurek; Kunszt, Peter Z.; Kuropatkin, Nickolai; Q.Lamb, Donald; Lampeitl, Hubert; Lee, Brian C.; Leger, R. French; Li, Nolan; Lin, Huan; Loh, Yeong-Shang; Long, Daniel C.; Loveday, Jon; Lupton, Robert H.; Malik, Tanu; BruceMargon; Matsubara, Takahiko; McGehee, Peregrine M.; McKay, Timothy A.; AveryMeiksin; Munn, Jeffrey A.; Nakajima, Reiko; Nash, Thomas; Neilsen, Eric H. Jr.; JoNewberg, Heidi; Newman, Peter R.; Nichol, Robert C.; Nicinski, Tom; Nieto-Santisteban, Maria; Nitta, Atsuko; Okamura, Sadanori; O'Mullane, William; Ostriker, Jeremiah P.; Owen, Russell; Padmanabhan, Nikhil; Peoples, John; Pier, Jeffrey R.; Pope, Adrian C.; Quinn, Thomas R.; Richards, Gordon T.; Richmond, Michael W.; Rix, Hans-Walter; Rockosi, Constance M.; Schlegel, David J.; Schneider, Donald P.; Scranton, Ryan; Sekiguchi, Maki; Seljak, Uros; Sergey, Gary; Sesar, Branimir; Sheldon, Erin; Shimasaku, Kazu; Siegmund, Walter A.; Silvestri, Nicole M.; Smith, J. Allyn; ́c, Vernesa Smolči; Snedden, Stephanie A.; AlbertStebbins; Stoughton, Chris; Strauss, Michael A.; SubbaRao, Mark; Szalay, Alexander S.; Szapudi, Istv ́an; Szkody, Paula; Szokoly, Gyula P.; Tegmark, Max; Teodoro, Luis; Thakar, AniruddhaR.; Tremonti, Christy; Tucker, Douglas L.; Uomoto, Alan; Vanden Berk, Daniel E.; Vandenberg, Jan; Vogeley, Michael S.; Voges, Wolfgang; Vogt, Nicole P.; M.Walkowicz, Lucianne; Wang, Shu-i; Weinberg, David H.; West, Andrew A.; White, Simon D.M.; Wilhite, BrianC.; Xu, Yongzhong; Yanny, Brian; Yasuda, Naoki; Yip, Ching-Wa; Yocum, D. R.; York, Donald G.; Zehavi, Idit; Zibetti, Stefano; Zucker, Daniel B.

    2004-01-01

    The Sloan Digital Sky Survey has validated and made publicly available its Second Data Release. This data release consists of 3324 square degrees of five-band (u g r i z) imaging data with photometry for over 88 million unique objects, 367,360 spectra of galaxies, quasars, stars and calibrating blank sky patches selected over 2627 degrees of this area, and tables of measured parameters from these data. The imaging data reach a depth of r ~ 22.2 (95% completeness limit for point sources) and are photometrically and astrometrically calibrated to 2% rms and 100 milli-arcsec rms per coordinate, respectively. The imaging data have all been processed through a new version of the SDSS imaging pipeline, in which the most important improvement since the last data release is fixing an error in the model fits to each object. The result is that model magnitudes are now a good proxy for point spread function (PSF) magnitudes for point sources, and Petrosian magnitudes for extended sources. The spectroscopy extends from 38...

  14. Detecting TLEs using a massive all-sky camera network

    Science.gov (United States)

    Garnung, M. B.; Celestin, S. J.

    2017-12-01

    Transient Luminous Events (TLEs) are large-scale optical events occurring in the upper-atmosphere from the top of thunderclouds up to the ionosphere. TLEs may have important effects in local, regional, and global scales, and many features of TLEs are not fully understood yet [e.g, Pasko, JGR, 115, A00E35, 2010]. Moreover, meteor events have been suggested to play a role in sprite initiation by producing ionospheric irregularities [e.g, Qin et al., Nat. Commun., 5, 3740, 2014]. The French Fireball Recovery and InterPlanetary Observation Network (FRIPON, https://www.fripon.org/?lang=en), is a national all-sky 30 fps camera network designed to continuously detect meteor events. We seek to make use of this network to observe TLEs over unprecedented space and time scales ( 1000×1000 km with continuous acquisition). To do so, we had to significantly modify FRIPON's triggering software Freeture (https://github.com/fripon/freeture) while leaving the meteor detection capability uncompromised. FRIPON has a great potential in the study of TLEs. Not only could it produce new results about spatial and time distributions of TLEs over a very large area, it could also be used to validate and complement observations from future space missions such as ASIM (ESA) and TARANIS (CNES). In this work, we present an original image processing algorithm that can detect sprites using all-sky cameras while strongly limiting the frequency of false positives and our ongoing work on sprite triangulation using the FRIPON network.

  15. Citizen Sky, Solving the Mystery of epsilon Aurigae

    Science.gov (United States)

    Turner, Rebecca; Price, A.; Kloppenborg, B.; Henden, A.

    2010-01-01

    Citizen Sky is a multi-year, NSF funded citizen science project involving the bright star eps Aur. The project was conceived by the IYA 2009 working group on Research Experiences for Students, Teachers, and Citizen-Scientists. Citizen Sky goes beyond simple observing to include a major data analysis component. The goal is to introduce the participant to the full scientific process from background research to paper writing for a peer-reviewed journal. It begins with a 10 Star Training Program of several types of binary and transient variable stars that are easy to observe from suburban locations with the naked eye. Participants then move on to monitoring the rare and mysterious 2009-2011 eclipse (already underway) of epsilon Aurigae. This object undergoes eclipses only every 27.1 years and each eclipse lasts nearly two years. The star is bright enough to be seen with the naked eye from most urban areas. Training will be provided in observing techniques as well as basic data analysis of photometric and visual datasets (light curve and period analysis). The project also involves two public workshops, one on observing (already held in August of 2009) and one on data analysis and scientific paper writing (to be held in 2010.) This project has been made possible by the National Science Foundation.

  16. An Ecocritical Reading of Paul Bowles's The Sheltering Sky

    Directory of Open Access Journals (Sweden)

    Hossein Sheikhzadeh

    2017-07-01

    Full Text Available Landscapes are not simply something objective and unchallenged out there but the work of the mind made by the strata of memory. This paper attempts to show that an ecocritical reading of Paul Bowles’s The Sheltering Sky (1949 helps one in better understanding of this novel of post-colonial alienation and existential despair. Bowles is an American writer and a composer who is undoubtedly the most arresting example of cross-cultural influence concerning a Western author and the Middle East and North Africa.  His fiction mostly focuses on American expatriates travelling in exotic locations. The Sheltering Sky is an encounter with the Sahara, not only the physical one but the desert of moral nihilism into which one may wander blindly. The boundless desert acts here as a metaphor and the journey symbolizes one’s own journey into the depth of his/her soul. The desert also projects an apocalyptic vision in the struggle between the West and the East and the Sahara becomes in fact a Conradian Heart of Darkness, an Eliotian Waste Land, and a Sartrean No Exit. In the novel the actual environment becomes in some ways pale and covert under the psyche of the writer. Consequently we come to know that Bowles's own knowledge and awareness of the same environments left traces in his work. Accordingly we may wrap up that the environment bears a direct impact on our understanding of it.

  17. Imaging the Southern Sky An Amateur Astronomer's Guide

    CERN Document Server

    Chadwick, Stephen

    2012-01-01

    "If you're looking for a handy reference guide to help you image and explore the many splendors of the southern sky, Imaging the Southern Sky is the book for you. The work features not only stunning color images, all taken by Stephen Chadwick, of the best galaxies, nebulae, and clusters available to astrophotographers, but also lesser-known objects, some of which have gone largely unexplored! Beginners and experienced observers alike should appreciate the book's remarkable imagery and simple text, which provides concise and accurate information on each object and its epoch 2000.0 position, and also expert testimony on its visual nature. Each object essay also includes a section on technical information that should help astrophotographers in their planning, including telescope aperture, focal length and ratio, camera used, exposure times, and field size. As a charming bonus, the authors have taken the liberty to name many of the lesser-known objects to reflect their New Zealand heritage. Constellation by con...

  18. Yearly, seasonal and monthly daily average diffuse sky radiation models

    International Nuclear Information System (INIS)

    Kassem, A.S.; Mujahid, A.M.; Turner, D.W.

    1993-01-01

    A daily average diffuse sky radiation regression model based on daily global radiation was developed utilizing two year data taken near Blytheville, Arkansas (Lat. =35.9 0 N, Long. = 89.9 0 W), U.S.A. The model has a determination coefficient of 0.91 and 0.092 standard error of estimate. The data were also analyzed for a seasonal dependence and four seasonal average daily models were developed for the spring, summer, fall and winter seasons. The coefficient of determination is 0.93, 0.81, 0.94 and 0.93, whereas the standard error of estimate is 0.08, 0.102, 0.042 and 0.075 for spring, summer, fall and winter, respectively. A monthly average daily diffuse sky radiation model was also developed. The coefficient of determination is 0.92 and the standard error of estimate is 0.083. A seasonal monthly average model was also developed which has 0.91 coefficient of determination and 0.085 standard error of estimate. The developed monthly daily average and daily models compare well with a selected number of previously developed models. (author). 11 ref., figs., tabs

  19. The cosmological principle is not in the sky

    Science.gov (United States)

    Park, Chan-Gyung; Hyun, Hwasu; Noh, Hyerim; Hwang, Jai-chan

    2017-08-01

    The homogeneity of matter distribution at large scales, known as the cosmological principle, is a central assumption in the standard cosmological model. The case is testable though, thus no longer needs to be a principle. Here we perform a test for spatial homogeneity using the Sloan Digital Sky Survey Luminous Red Galaxies (LRG) sample by counting galaxies within a specified volume with the radius scale varying up to 300 h-1 Mpc. We directly confront the large-scale structure data with the definition of spatial homogeneity by comparing the averages and dispersions of galaxy number counts with allowed ranges of the random distribution with homogeneity. The LRG sample shows significantly larger dispersions of number counts than the random catalogues up to 300 h-1 Mpc scale, and even the average is located far outside the range allowed in the random distribution; the deviations are statistically impossible to be realized in the random distribution. This implies that the cosmological principle does not hold even at such large scales. The same analysis of mock galaxies derived from the N-body simulation, however, suggests that the LRG sample is consistent with the current paradigm of cosmology, thus the simulation is also not homogeneous in that scale. We conclude that the cosmological principle is neither in the observed sky nor demanded to be there by the standard cosmological world model. This reveals the nature of the cosmological principle adopted in the modern cosmology paradigm, and opens a new field of research in theoretical cosmology.

  20. A prototype for the PASS Permanent All Sky Survey

    Science.gov (United States)

    Deeg, H. J.; Alonso, R.; Belmonte, J. A.; Horne, K.; Alsubai, K.; Collier Cameron, A.; Doyle, L. R.

    2004-10-01

    A prototype system for the Permanent All Sky Survey (PASS) project is presented. PASS is a continuous photometric survey of the entire celestial sphere with a high temporal resolution. Its major objectives are the detection of all giant-planet transits (with periods up to some weeks) across stars up to mag 10.5, and to deliver continuously photometry that is useful for the study of any variable stars. The prototype is based on CCD cameras with short focal length optics on a fixed mount. A small dome to house it at Teide Observatory, Tenerife, is currently being constructed. A placement at the antarctic Dome C is also being considered. The prototype will be used for a feasibility study of PASS, to define the best observing strategies, and to perform a detailed characterization of the capabilities and scope of the survey. Afterwards, a first partial sky surveying will be started with it. That first survey may be able to detect transiting planets during its first few hundred hours of operation. It will also deliver a data set around which software modules dealing with the various scientific objectives of PASS will be developed. The PASS project is still in its early phase and teams interested in specific scientific objectives, in providing technical expertise, or in participating with own observations are invited to collaborate.

  1. Analyzing the Gamma-Ray Sky with Wavelets

    Energy Technology Data Exchange (ETDEWEB)

    Balaji, Bhaskaran [Johns Hopkins U.; Cholis, Ilias [Johns Hopkins U.; Fox, Patrick J. [Fermilab; McDermott, Samuel D. [Fermilab

    2018-03-05

    We analyze the gamma-ray sky at energies of 0.5 to 50 GeV using the undecimated wavelet transform on the sphere. Focusing on the inner $60^{\\circ} \\times 60^{\\circ}$ of the sky, we identify and characterize four separate residuals beyond the expected Milky Way diffuse emission. We detect the \\textit{Fermi} Bubbles, finding compelling evidence that they are diffuse in nature and contain very little small-scale structure. We detect the "cocoon" inside the Southern Bubble, and we also identify its northern counterpart above 2 GeV. The Northern Cocoon lies along the same axis but is $\\sim 30 \\%$ dimmer than the southern one. We characterize the Galactic center excess, which we find extends up to $20^{\\circ}$ in $|b|$. At latitudes $|b| \\leq 5^{\\circ}$ we find evidence for power in small angular scales that could be the result of point-source contributions, but for $|b| \\geq 5^{\\circ}$ the Galactic center excess is dominantly diffuse in its nature. Our findings show that either the Galactic center excess and {\\it Fermi} Bubbles connect smoothly or that the Bubbles brighten significantly below $15^\\circ$ in latitude. We find that the Galactic center excess appears off-center by a few degrees towards negative $\\ell$. Additionally, we find and characterize two emissions along the Galactic disk centered at $\\ell \\simeq +25^{\\circ}$ and $-20^{\\circ}$. These emissions are significantly more elongated along the Galactic disk than the Galactic center excess.

  2. High Turbidity Solis Clear Sky Model: Development and Validation

    Directory of Open Access Journals (Sweden)

    Pierre Ineichen

    2018-03-01

    Full Text Available The Solis clear sky model is a spectral scheme based on radiative transfer calculations and the Lambert–Beer relation. Its broadband version is a simplified fast analytical version; it is limited to broadband aerosol optical depths lower than 0.45, which is a weakness when applied in countries with very high turbidity such as China or India. In order to extend the use of the original simplified version of the model for high turbidity values, we developed a new version of the broadband Solis model based on radiative transfer calculations, valid for turbidity values up to 7, for the three components, global, beam, and diffuse, and for the four aerosol types defined by Shettle and Fenn. A validation of low turbidity data acquired in Geneva shows slightly better results than the previous version. On data acquired at sites presenting higher turbidity data, the bias stays within ±4% for the beam and the global irradiances, and the standard deviation around 5% for clean and stable condition data and around 12% for questionable data and variable sky conditions.

  3. The Transient High Energy Sky and Early Universe Surveyor (THESEUS)

    Science.gov (United States)

    Amati, Lorenzo; O'Brien, Paul T.; Götz, Diego

    2016-07-01

    The Transient High Energy Sky and Early Universe Surveyor (THESEUS) is a mission concept under development by a large international collaboration aimed at exploiting gamma-ray bursts for investigating the early Universe. The main scientific objectives of THESEUS include: investigating the star formation rate and metallicity evolution of the ISM and IGM up to redshift 9-10, detecting the first generation (pop III) of stars, studying the sources and physics of re-ionization, detecting the faint end of galaxies luminosity function. These goals will be achieved through a unique combination of instruments allowing GRB detection and arcmin localization over a broad FOV (more than 1sr) and an energy band extending from several MeVs down to 0.3 keV with unprecedented sensitivity, as well as on-board prompt (few minutes) follow-up with a 0.6m class IR telescope with both imaging and spectroscopic capabilities. Such instrumentation will also allow THESEUS to unveil and study the population of soft and sub-energetic GRBs, and, more in general, to perform monitoring and survey of the X-ray sky with unprecedented sensitivity.

  4. Spectral and diurnal variations in clear sky planetary albedo

    Science.gov (United States)

    Briegleb, B.; Ramanathan, V.

    1982-01-01

    Spectral and diurnal variations in the clear sky planetary albedo of the earth are calculated using a radiative transfer model to obtain January and July values for a 5 deg x 5 deg global grid. The model employs observed climatological values of temperatures, humidities, snow and sea-ice cover. The diurnal cycle of clear sky albedo is calculated in the following intervals: 0.2-0.5, 0.5-0.7, and 0.7-4 microns. Observed ozone distribution is specified as a function of latitude and season. The 0.2-0.5 micron spectral albedo is 10-20% higher than the total albedo for all latitudes because of Rayleigh scattering; the 0.5-0.7 micron albedo differs from the total albedo by 1-2% for most latitudes, while the 0.7-4 micron albedo is 5-10% lower than the total because of strong atmospheric absorption. Planetary albedo decreases from morning to local noon, with diurnal variations being particularly strong over water.

  5. Sky Of Stars: Visualizing Gaia Data in the Fiske Planetarium

    Science.gov (United States)

    Ibarra Perez, Luz; Berta-Thompson, Zachory K.; Conant, Nickolas Alexander

    2018-06-01

    ESA’s satellite Gaia has collected and continues to collect data about the positions, kinematics, and luminosity of more than one billion stars. This census is the most accurate census of the Milky Way to this day. The Fiske Planetarium at the University of Colorado hosts a state-of-the-art 8K projector and the ability to render the 3D positions of stars in real time. Using Python, Astropy and ADQL, I wrote tools to explore the Gaia data, creating different ways to visualize this three-dimensional map of our Galaxy. I created catalogs that the Fiske planetarium can read and project, including millions of stars that our naked eyes can’t see. For the first time ever, we are able to show in the planetarium what the sky would look like if our eyes were 10X, 100X, or 1000X bigger than they really are. With accurate positions and proper motions, we can also jump in time and roughly observe what our sky will look like in a thousand or in a million years. This catalog is now used in classes and talks, so students and planetarium visitors are able to travel through these stars and observe what they have looked like or what they will look like as the years go by.

  6. The Sloan Digital Sky Survey COADD: 275 deg2 of deep Sloan Digital Sky Survey imaging on stripe 82

    International Nuclear Information System (INIS)

    Annis, James; Soares-Santos, Marcelle; Dodelson, Scott; Hao, Jiangang; Jester, Sebastian; Johnston, David E.; Kubo, Jeffrey M.; Lampeitl, Hubert; Lin, Huan; Miknaitis, Gajus; Yanny, Brian; Strauss, Michael A.; Gunn, James E.; Lupton, Robert H.; Becker, Andrew C.; Ivezić, Željko; Fan, Xiaohui; Jiang, Linhua; Seo, Hee-Jong; Simet, Melanie

    2014-01-01

    We present details of the construction and characterization of the coaddition of the Sloan Digital Sky Survey (SDSS) Stripe 82 ugriz imaging data. This survey consists of 275 deg 2 of repeated scanning by the SDSS camera over –50° ≤ α ≤ 60° and –1.°25 ≤ δ ≤ +1.°25 centered on the Celestial Equator. Each piece of sky has ∼20 runs contributing and thus reaches ∼2 mag fainter than the SDSS single pass data, i.e., to r ∼ 23.5 for galaxies. We discuss the image processing of the coaddition, the modeling of the point-spread function (PSF), the calibration, and the production of standard SDSS catalogs. The data have an r-band median seeing of 1.''1 and are calibrated to ≤1%. Star color-color, number counts, and PSF size versus modeled size plots show that the modeling of the PSF is good enough for precision five-band photometry. Structure in the PSF model versus magnitude plot indicates minor PSF modeling errors, leading to misclassification of stars as galaxies, as verified using VVDS spectroscopy. There are a variety of uses for this wide-angle deep imaging data, including galactic structure, photometric redshift computation, cluster finding and cross wavelength measurements, weak lensing cluster mass calibrations, and cosmic shear measurements.

  7. Dark Skies Awareness Programs for the U.S. International Year of Astronomy

    Science.gov (United States)

    Walker, Constance E.; U. S. IYA Dark Skies Working Group

    2009-01-01

    The loss of a dark night sky as a natural resource is a growing concern. It impacts not only astronomical research, but also our ecology, health, safety, economics and energy conservation. For this reason, "Dark Skies are a Universal Resource” is one of seven primary themes of the U.S. International Year of Astronomy program in 2009. Its goal is to raise public awareness of the impact of artificial lighting on local environments by getting people involved in a variety of dark skies-related programs. To reach this goal, activities have been developed that: 1) Teach about dark skies using new technology (e.g., an activity-based planetarium show on DVD, podcasting, social networking, Second Life) 2) Provide thematic events on light pollution at star parties and observatory open houses (Dark Skies Discovery Sites, Astronomy Nights in the (National) Parks, Sidewalk Astronomy Nights) 3) Organize an event in the arts (e.g., a photography contest) 4) Involve citizen-scientists in unaided-eye and digital-meter star counting programs, as well as RFI monitoring (e.g., GLOBE at Night and Quiet Skies) and 5) Raise awareness about the link between light pollution and public health, economic issues, ecological consequences, energy conservation, safety and security (e.g., the Dark Skies Toolkit, Good Neighbor Lighting, Earth Hour, National Dark Skies Week, traveling exhibits and a 6-minute video tutorial). To deliver these programs, strategic networks have been established with astronomy clubs (ASP's Night Sky Network's astronomy clubs and the Astronomical League), science and nature centers (Astronomy from the Ground Up and the Association of Science and Technology), educational programs (Project ASTRO and GLOBE) and the International Dark-sky Association. The poster will describe the "know-how” and the means for people to become community advocates in promoting Dark Skies programs as public events at their home institutions. For more information, visit http://astronomy2009

  8. Analysis of Ozone in Cloudy Versus Clear Sky Conditions

    Science.gov (United States)

    Strode, Sarah; Douglass, Anne; Ziemke, Jerald

    2016-01-01

    Convection impacts ozone concentrations by transporting ozone vertically and by lofting ozone precursors from the surface, while the clouds and lighting associated with convection affect ozone chemistry. Observations of the above-cloud ozone column (Ziemke et al., 2009) derived from the OMI instrument show geographic variability, and comparison of the above-cloud ozone with all-sky tropospheric ozone columns from OMI indicates important regional differences. We use two global models of atmospheric chemistry, the GMI chemical transport model (CTM) and the GEOS-5 chemistry climate model, to diagnose the contributions of transport and chemistry to observed differences in ozone between areas with and without deep convection, as well as differences in clean versus polluted convective regions. We also investigate how the above-cloud tropospheric ozone from OMI can provide constraints on the relationship between ozone and convection in a free-running climate simulation as well as a CTM.

  9. Information integration for a sky survey by data warehousing

    Science.gov (United States)

    Luo, A.; Zhang, Y.; Zhao, Y.

    The virtualization service of data system for a sky survey LAMOST is very important for astronomers The service needs to integrate information from data collections catalogs and references and support simple federation of a set of distributed files and associated metadata Data warehousing has been in existence for several years and demonstrated superiority over traditional relational database management systems by providing novel indexing schemes that supported efficient on-line analytical processing OLAP of large databases Now relational database systems such as Oracle etc support the warehouse capability which including extensions to the SQL language to support OLAP operations and a number of metadata management tools have been created The information integration of LAMOST by applying data warehousing is to effectively provide data and knowledge on-line

  10. Second ROSAT all-sky survey (2RXS) source catalogue

    Science.gov (United States)

    Boller, Th.; Freyberg, M. J.; Trümper, J.; Haberl, F.; Voges, W.; Nandra, K.

    2016-04-01

    Aims: We present the second ROSAT all-sky survey source catalogue, hereafter referred to as the 2RXS catalogue. This is the second publicly released ROSAT catalogue of point-like sources obtained from the ROSAT all-sky survey (RASS) observations performed with the position-sensitive proportional counter (PSPC) between June 1990 and August 1991, and is an extended and revised version of the bright and faint source catalogues. Methods: We used the latest version of the RASS processing to produce overlapping X-ray images of 6.4° × 6.4° sky regions. To create a source catalogue, a likelihood-based detection algorithm was applied to these, which accounts for the variable point-spread function (PSF) across the PSPC field of view. Improvements in the background determination compared to 1RXS were also implemented. X-ray control images showing the source and background extraction regions were generated, which were visually inspected. Simulations were performed to assess the spurious source content of the 2RXS catalogue. X-ray spectra and light curves were extracted for the 2RXS sources, with spectral and variability parameters derived from these products. Results: We obtained about 135 000 X-ray detections in the 0.1-2.4 keV energy band down to a likelihood threshold of 6.5, as adopted in the 1RXS faint source catalogue. Our simulations show that the expected spurious content of the catalogue is a strong function of detection likelihood, and the full catalogue is expected to contain about 30% spurious detections. A more conservative likelihood threshold of 9, on the other hand, yields about 71 000 detections with a 5% spurious fraction. We recommend thresholds appropriate to the scientific application. X-ray images and overlaid X-ray contour lines provide an additional user product to evaluate the detections visually, and we performed our own visual inspections to flag uncertain detections. Intra-day variability in the X-ray light curves was quantified based on the

  11. Data transmission protocol for Pi-of-the-Sky cameras

    Science.gov (United States)

    Uzycki, J.; Kasprowicz, G.; Mankiewicz, M.; Nawrocki, K.; Sitek, P.; Sokolowski, M.; Sulej, R.; Tlaczala, W.

    2006-10-01

    The large amount of data collected by the automatic astronomical cameras has to be transferred to the fast computers in a reliable way. The method chosen should ensure data streaming in both directions but in nonsymmetrical way. The Ethernet interface is very good choice because of its popularity and proven performance. However it requires TCP/IP stack implementation in devices like cameras for full compliance with existing network and operating systems. This paper describes NUDP protocol, which was made as supplement to standard UDP protocol and can be used as a simple-network protocol. The NUDP does not need TCP protocol implementation and makes it possible to run the Ethernet network with simple devices based on microcontroller and/or FPGA chips. The data transmission idea was created especially for the "Pi of the Sky" project.

  12. RADIO-SELECTED QUASARS IN THE SLOAN DIGITAL SKY SURVEY

    International Nuclear Information System (INIS)

    McGreer, Ian D.; Helfand, David J.; White, Richard L.

    2009-01-01

    We have conducted a pilot survey for z > 3.5 quasars by combining the FIRST radio survey with the Sloan Digital Sky Survey (SDSS). While SDSS already targets FIRST sources for spectroscopy as quasar candidates, our survey includes fainter quasars and greatly improves the discovery rate by using strict astrometric criteria for matching the radio and optical positions. Our method allows for selection of high-redshift quasars with less color bias than with optical selection, as using radio selection essentially eliminates stellar contamination. We report the results of spectroscopy for 45 candidates, including 29 quasars in the range 0.37 3.5. We compare quasars selected using radio and optical criteria, and find that radio-selected quasars have a much higher fraction of moderately reddened objects. We derive a radio-loud quasar luminosity function at 3.5 < z < 4.0, and find that it is in good agreement with expectations from prior SDSS results.

  13. The Innsbruck/ESO sky models and telluric correction tools*

    Directory of Open Access Journals (Sweden)

    Kimeswenger S.

    2015-01-01

    While the ground based astronomical observatories just have to correct for the line-of-sight integral of these effects, the Čerenkov telescopes use the atmosphere as the primary detector. The measured radiation originates at lower altitudes and does not pass through the entire atmosphere. Thus, a decent knowledge of the profile of the atmosphere at any time is required. The latter cannot be achieved by photometric measurements of stellar sources. We show here the capabilities of our sky background model and data reduction tools for ground-based optical/infrared telescopes. Furthermore, we discuss the feasibility of monitoring the atmosphere above any observing site, and thus, the possible application of the method for Čerenkov telescopes.

  14. Automated Meteor Detection by All-Sky Digital Camera Systems

    Science.gov (United States)

    Suk, Tomáš; Šimberová, Stanislava

    2017-12-01

    We have developed a set of methods to detect meteor light traces captured by all-sky CCD cameras. Operating at small automatic observatories (stations), these cameras create a network spread over a large territory. Image data coming from these stations are merged in one central node. Since a vast amount of data is collected by the stations in a single night, robotic storage and analysis are essential to processing. The proposed methodology is adapted to data from a network of automatic stations equipped with digital fish-eye cameras and includes data capturing, preparation, pre-processing, analysis, and finally recognition of objects in time sequences. In our experiments we utilized real observed data from two stations.

  15. Estimation of clear sky hourly global solar radiation in Iraq

    Energy Technology Data Exchange (ETDEWEB)

    Al-Jumaily, Kais J.; Al-Zuhairi, Munya F.; Mahdi, Zahraa S. [Department of Atmospheric Sciences, College of Science, Al-Mustansiriyah University, Baghdad (Iraq)

    2012-07-01

    The availability of hourly solar radiation data is very important for applications utilizing solar energy and for climate and environmental aspects. The aim of this work is to use a simple model for estimating hourly global solar radiation under clear sky condition in Iraq. Calculations were compared with measurements obtained from local station in Baghdad city and from Meteosat satellite data for different locations in Iraq. The statistical test methods of the mean bias error (MBE), root mean square error (RMSE) and t-test were used to evaluate the performance of the model. Results indicated that a fairly good agreement exists between calculated and measured values for all locations in Iraq. Since the model is independent of any meteorological variable, it would be of a practical use for rural areas where no meteorological data are available.

  16. Classification of Variable Objects in Massive Sky Monitoring Surveys

    Science.gov (United States)

    Woźniak, Przemek; Wyrzykowski, Łukasz; Belokurov, Vasily

    2012-03-01

    The era of great sky surveys is upon us. Over the past decade we have seen rapid progress toward a continuous photometric record of the optical sky. Numerous sky surveys are discovering and monitoring variable objects by hundreds of thousands. Advances in detector, computing, and networking technology are driving applications of all shapes and sizes ranging from small all sky monitors, through networks of robotic telescopes of modest size, to big glass facilities equipped with giga-pixel CCD mosaics. The Large Synoptic Survey Telescope will be the first peta-scale astronomical survey [18]. It will expand the volume of the parameter space available to us by three orders of magnitude and explore the mutable heavens down to an unprecedented level of sensitivity. Proliferation of large, multidimensional astronomical data sets is stimulating the work on new methods and tools to handle the identification and classification challenge [3]. Given exponentially growing data rates, automated classification of variability types is quickly becoming a necessity. Taking humans out of the loop not only eliminates the subjective nature of visual classification, but is also an enabling factor for time-critical applications. Full automation is especially important for studies of explosive phenomena such as γ-ray bursts that require rapid follow-up observations before the event is over. While there is a general consensus that machine learning will provide a viable solution, the available algorithmic toolbox remains underutilized in astronomy by comparison with other fields such as genomics or market research. Part of the problem is the nature of astronomical data sets that tend to be dominated by a variety of irregularities. Not all algorithms can handle gracefully uneven time sampling, missing features, or sparsely populated high-dimensional spaces. More sophisticated algorithms and better tools available in standard software packages are required to facilitate the adoption of

  17. Cool covered sky-splitting spectrum-splitting FK

    Energy Technology Data Exchange (ETDEWEB)

    Mohedano, Rubén; Chaves, Julio; Falicoff, Waqidi; Hernandez, Maikel; Sorgato, Simone [LPI, Altadena, CA, USA and Madrid (Spain); Miñano, Juan C.; Benitez, Pablo [LPI, Altadena, CA, USA and Madrid, Spain and Universidad Politécnica de Madrid (UPM), Madrid (Spain); Buljan, Marina [Universidad Politécnica de Madrid (UPM), Madrid (Spain)

    2014-09-26

    Placing a plane mirror between the primary lens and the receiver in a Fresnel Köhler (FK) concentrator gives birth to a quite different CPV system where all the high-tech components sit on a common plane, that of the primary lens panels. The idea enables not only a thinner device (a half of the original) but also a low cost 1-step manufacturing process for the optics, automatic alignment of primary and secondary lenses, and cell/wiring protection. The concept is also compatible with two different techniques to increase the module efficiency: spectrum splitting between a 3J and a BPC Silicon cell for better usage of Direct Normal Irradiance DNI, and sky splitting to harvest the energy of the diffuse radiation and higher energy production throughout the year. Simple calculations forecast the module would convert 45% of the DNI into electricity.

  18. All-sky photogrammetry techniques to georeference a cloud field

    Science.gov (United States)

    Crispel, Pierre; Roberts, Gregory

    2018-01-01

    In this study, we present a novel method of identifying and geolocalizing cloud field elements from a portable all-sky camera stereo network based on the ground and oriented towards zenith. The methodology is mainly based on stereophotogrammetry which is a 3-D reconstruction technique based on triangulation from corresponding stereo pixels in rectified images. In cases where clouds are horizontally separated, identifying individual positions is performed with segmentation techniques based on hue filtering and contour detection algorithms. Macroscopic cloud field characteristics such as cloud layer base heights and velocity fields are also deduced. In addition, the methodology is fitted to the context of measurement campaigns which impose simplicity of implementation, auto-calibration, and portability. Camera internal geometry models are achieved a priori in the laboratory and validated to ensure a certain accuracy in the peripheral parts of the all-sky image. Then, stereophotogrammetry with dense 3-D reconstruction is applied with cameras spaced 150 m apart for two validation cases. The first validation case is carried out with cumulus clouds having a cloud base height at 1500 m a.g.l. The second validation case is carried out with two cloud layers: a cumulus fractus layer with a base height at 1000 m a.g.l. and an altocumulus stratiformis layer with a base height of 2300 m a.g.l. Velocity fields at cloud base are computed by tracking image rectangular patterns through successive shots. The height uncertainty is estimated by comparison with a Vaisala CL31 ceilometer located on the site. The uncertainty on the horizontal coordinates and on the velocity field are theoretically quantified by using the experimental uncertainties of the cloud base height and camera orientation. In the first cumulus case, segmentation of the image is performed to identify individuals clouds in the cloud field and determine the horizontal positions of the cloud centers.

  19. Two-dimensional Topology of the Sloan Digital Sky Survey

    Science.gov (United States)

    Hoyle, Fiona; Vogeley, Michael S.; Gott, J. Richard, III; Blanton, Michael; Tegmark, Max; Weinberg, David H.; Bahcall, N.; Brinkmann, J.; York, D.

    2002-12-01

    We present the topology of a volume-limited sample of 11,884 galaxies, selected from an apparent magnitude limited sample of over 100,000 galaxies observed as part of the Sloan Digital Sky Survey (SDSS). The data currently cover three main regions on the sky: one in the Galactic north and one in the south, both at zero degrees declination, and one area in the north at higher declination. Each of these areas covers a wide range of survey longitude but a narrow range of survey latitude, allowing the two-dimensional genus to be measured. The genus curves of the SDSS subsamples are similar, after appropriately normalizing these measurements for the different areas. We sum the genus curves from the three areas to obtain the total genus curve of the SDSS. The total curve has a shape similar to the genus curve derived from mock catalogs drawn from the Hubble volume ΛCDM simulation and is similar to that of a Gaussian random field. Likewise, comparison with the genus of the Two-Degree Field Galaxy Redshift Survey, after normalization for the difference in area, reveals remarkable similarity in the topology of these samples. We test for the effects of galaxy-type segregation by splitting the SDSS data into thirds, based on the u*-r* colors of the galaxies, and measure the genus of the reddest and bluest subsamples. This red/blue split in u*-r* is essentially a split by morphology, as explained by Strateva and coworkers. We find that the genus curve for the reddest galaxies exhibits a ``meatball'' shift of the topology-reflecting the concentration of red galaxies in high-density regions-compared to the bluest galaxies and the full sample, in agreement with predictions from simulations.

  20. The VLA Sky Survey (VLASS): Description and Science Goals

    Science.gov (United States)

    Lacy, Mark; Baum, Stefi Alison; Chandler, Claire J.; Chatterjee, Shami; Murphy, Eric J.; Myers, Steven T.; VLASS Survey Science Group

    2016-01-01

    The VLA Sky Survey (VLASS) will cover 80% of the sky to a target depth of 70muJy in the 2-4GHz S-band of the Karl G. Jansky Very Large Array. With a resolution of 2.5 arcseconds, it will deliver the highest angular resolution of any wide area radio survey. Each area of the survey will be observed in three epochs spaced by 32 months in order to investigate the transient radio source population over an unprecedented combination of depth and area, resulting in a uniquely powerful search for hidden explosions in the Universe. The survey will be carried out in full polarization, allowing the characterization of the magneto-ionic medium in AGN and intervening galaxies over a wide range of redshifts, and the study of Faraday rotating foregrounds such as ionized bubbles in the Milky Way. The high angular resolution will allow us to make unambiguous identifications of nearly 10 million radio sources, comprised of both extragalactic objects and more nearby radio sources in the Milky Way, through matching to wide area optical/IR surveys such as SDSS, PanSTARRS, DES, LSST, EUCLID, WFIRST and WISE. Integral to the VLASS plan is an Education and Public Outreach component that will seek to inform and educate both the scientific community and the general public about radio astronomy through the use of social media, citizen science and educational activities. We will discuss opportunities for community involvement in VLASS, including the development of Enhanced Data Products and Services that will greatly increase the scientific utility of the survey.

  1. SkyDiscovery: Humans and Machines Working Together

    Science.gov (United States)

    Donalek, Ciro; Fang, K.; Drake, A. J.; Djorgovski, S. G.; Graham, M. J.; Mahabal, A.; Williams, R.

    2011-01-01

    Synoptic sky surveys are now discovering tens to hundreds of transient events every clear night, and that data rate is expected to increase dramatically as we move towards the LSST. A key problem is classification of transients, which determines their scientific interest and possible follow-up. Some of the relevant information is contextual, and easily recognizable by humans looking at images, but it is very hard to encode in the data pipelines. Crowdsourcing (aka Citizen Science) provides one possible way to gather such information. SkyDiscovery.org is a website that allows experts and citizen science enthusiasts to work together and share information in a collaborative scientific discovery environment. Currently there are two projects running on the website. In the Event Classification project users help finding candidate transients through a series of questions related to the images shown. Event classification depends very much form the contextual information and humans are remarkably effective at recognizing noise in incomplete heterogeneous data and figuring out which contextual information is important. In the SNHunt project users are requested to look for new objects appearing on images of galaxies taken by the Catalina Real-time Transient Survey, in order to find all the supernovae occurring in nearby bright galaxies. Images are served alongside with other tools that can help the discovery. A multi level approach allows the complexity of the interface to be tailored to the expertise level of the user. An entry level user can just review images and validate events as being real, while a more advanced user would be able to interact with the data associated to an event. The data gathered will not be only analyzed and used directly for some specific science project, but also to train well-defined algorithms to be used in automating such data analysis in the future.

  2. The use of a sky camera for solar radiation estimation based on digital image processing

    International Nuclear Information System (INIS)

    Alonso-Montesinos, J.; Batlles, F.J.

    2015-01-01

    The necessary search for a more sustainable global future means using renewable energy sources to generate pollutant-free electricity. CSP (Concentrated solar power) and PV (photovoltaic) plants are the systems most in demand for electricity production using solar radiation as the energy source. The main factors affecting final electricity generation in these plants are, among others, atmospheric conditions; therefore, knowing whether there will be any change in the solar radiation hitting the plant's solar field is of fundamental importance to CSP and PV plant operators in adapting the plant's operation mode to these fluctuations. Consequently, the most useful technology must involve the study of atmospheric conditions. This is the case for sky cameras, an emerging technology that allows one to gather sky information with optimal spatial and temporal resolution. Hence, in this work, a solar radiation estimation using sky camera images is presented for all sky conditions, where beam, diffuse and global solar radiation components are estimated in real-time as a novel way to evaluate the solar resource from a terrestrial viewpoint. - Highlights: • Using a sky camera, the solar resource has been estimated for one minute periods. • The sky images have been processed to estimate the solar radiation at pixel level. • The three radiation components have been estimated under all sky conditions. • Results have been presented for cloudless, partially-cloudy and overcast conditions. • For beam and global radiation, the nRMSE value is of about 11% under overcast skies.

  3. Planning and scheduling algorithms for the COSMO-SkyMed constellation

    NARCIS (Netherlands)

    Bianchessi, Nicola; Righini, Giovanni

    2008-01-01

    The COSMO-SkyMed satellite constellation for the observation of the Earth is made of four satellites equipped with radar instruments and is intended for dual use, i.e. for security as well as for environmental monitoring purpose. The planning and scheduling problem for the COSMO-SkyMed constellation

  4. Study of X-ray transients with Scanning Sky Monitor (SSM) onboard ...

    Indian Academy of Sciences (India)

    M. C. RAMADEVI

    MS received 1 September 2017; accepted 19 December 2017; published online 10 February 2018. Abstract. Scanning Sky Monitor (SSM) onboard AstroSat is an X-ray sky monitor in the ..... 31(2–3), 99. Ramadevi M. C., Seetha S., Babu V. C., Ashoka B. N., Sreeku- mar P. 2006, Optimization of Gas Proportional Coun-.

  5. Planck 2013 results. XI. All-sky model of thermal dust emission

    DEFF Research Database (Denmark)

    Abergel, A.; Ade, P. A. R.; Aghanim, N.

    2014-01-01

    This paper presents an all-sky model of dust emission from the Planck 353, 545, and 857 GHz, and IRAS 100 mu m data. Using a modified blackbody fit to the data we present all-sky maps of the dust optical depth, temperature, and spectral index over the 353-3000 GHz range. This model is a good repr...

  6. Mapping and assessing the environmental impacts of border tactical infrastructure in the Sky Island Region

    Science.gov (United States)

    Caroline Patrick-Birdwell; Sergio Avila-Villegas; Jenny Neeley; Louise Misztal

    2013-01-01

    In this project we mapped the different types of border barriers, identified impacts of border infrastructure on public and private lands and conducted spatial analyses within the approximately 200 miles of international border in the Sky Island region. The Sky Island region, bisected by the U.S.-Mexico border, is critically important for its biodiversity and...

  7. Responding to climate change impacts in the Sky Island Region: From planning to action

    Science.gov (United States)

    Louise W. Misztal; Gregg Garfin; Lara Hansen

    2013-01-01

    Addressing the increasing effects of climate change on natural resources requires multiple organizations, agencies, and institutions working cooperatively to incorporate climate change into resource management. In the Sky Island region of the southwestern United States and northern Mexico, Sky Island Alliance, a non-governmental organization, has convened a series of...

  8. MonetDB/SQL Meets SkyServer: the Challenges of a Scientific Database.

    NARCIS (Netherlands)

    M.G. Ivanova (Milena); N.J. Nes (Niels); R.A. Goncalves (Romulo); M.L. Kersten (Martin)

    2007-01-01

    textabstractThis paper presents our experiences in porting the Sloan Digital Sky Survey(SDSS)/ SkyServer to the state-of-the-art open source database system MonetDB/SQL. SDSS acts as a well-documented benchmark for scientific database management. We have achieved a fully functional prototype for the

  9. The urban astronomer's guide a walking tour of the cosmos for city sky watchers

    CERN Document Server

    Mollise, Rod

    2006-01-01

    This book covers the "why," "how," and "what" of astronomy under light-polluted skies. It is aimed at urban astronomers and showcases the countless objects - galaxies, nebulae, and star clusters - that can be seen in even in heavily light polluted urban skies.

  10. Photosynthetically-active radiation: sky radiance distributions under clear and overcast conditions

    International Nuclear Information System (INIS)

    Grant, R.H.; Heisler, G.M.; Gao, W.

    1996-01-01

    The photosynthetically active radiation (PAR), defined as the wavelength band of 0.400 μm to 0.700 μm, represents most of the visible solar radiation. Although the proportion of global irradiance that originates from diffuse sky radiation is higher for PAR than for all solar shortwave radiation, it is often assumed that the PAR diffuse sky radiation is distributed identically to that of all shortwave solar radiation. This assumption has not been tested. PAR sky radiance measurements were made in a rural area over a wide range of solar zenith angles. The distribution of PAR sky radiance was modeled using physically-based, non-linear equations.For clear skies, the normalized sky radiance distribution (N) was best modeled using the scattering angle (ψ) and the zenith position in the sky (Θ) as N (Θ, ψ) = 0.0361 [6.3 + (1 + cos 2 Θ / (1 - cos ψ)] [1-e -0.31 sec ( Θ]. The angle Ψ is defined by cos ψ = cos Θ cos Θ * + sin Θ sin Θ * cos Φ, where solar zenith angle is Θ* and the difference in azimuth between the sun and the position in the sky is Φ. Modeling of the overcast sky depended on the visibility of the solar disk. The translucent middle/high cloud overcast conditions (cloud base greater than 300 m above ground level) were best modeled as: N(Θ∗, ψ) = 0.149 + 0.084Θ∗ + 1.305e −2.5ψ while the translucent low cloud overcast conditions (cloud base less than 300 m above ground level) were best modeled as: N(Θ∗, ψ) = 0.080 + 0.058Θ∗ + 0.652e −2.1ψ . The obscured overcast sky condition (solar disk obscured) was best modeled as: N(Θ) = 0.441 [1 + 4.6cos Θ] /[1 + 4.6]. The unit of N for all equations is π Sr −1 , so that integration of each function over the sky hemisphere yields 1.0.These equations can be applied directly to the sky diffuse irradiance on the horizontal, I diff , to provide radiance distributions for the sky. Estimates of actual sky radiance distribution can be estimated from N a (Θ, ψ) = I diff N(Θ,

  11. Clear-sky classification procedures and models using a world-wide data-base

    International Nuclear Information System (INIS)

    Younes, S.; Muneer, T.

    2007-01-01

    Clear-sky data need to be extracted from all-sky measured solar-irradiance dataset, often by using algorithms that rely on other measured meteorological parameters. Current procedures for clear-sky data extraction have been examined and compared with each other to determine their reliability and location dependency. New clear-sky determination algorithms are proposed that are based on a combination of clearness index, diffuse ratio, cloud cover and Linke's turbidity limits. Various researchers have proposed clear-sky irradiance models that rely