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Sample records for ps statistical techniques

  1. Lightweight and Statistical Techniques for Petascale Debugging: Correctness on Petascale Systems (CoPS) Preliminry Report

    Energy Technology Data Exchange (ETDEWEB)

    de Supinski, B R; Miller, B P; Liblit, B

    2011-09-13

    Petascale platforms with O(10{sup 5}) and O(10{sup 6}) processing cores are driving advancements in a wide range of scientific disciplines. These large systems create unprecedented application development challenges. Scalable correctness tools are critical to shorten the time-to-solution on these systems. Currently, many DOE application developers use primitive manual debugging based on printf or traditional debuggers such as TotalView or DDT. This paradigm breaks down beyond a few thousand cores, yet bugs often arise above that scale. Programmers must reproduce problems in smaller runs to analyze them with traditional tools, or else perform repeated runs at scale using only primitive techniques. Even when traditional tools run at scale, the approach wastes substantial effort and computation cycles. Continued scientific progress demands new paradigms for debugging large-scale applications. The Correctness on Petascale Systems (CoPS) project is developing a revolutionary debugging scheme that will reduce the debugging problem to a scale that human developers can comprehend. The scheme can provide precise diagnoses of the root causes of failure, including suggestions of the location and the type of errors down to the level of code regions or even a single execution point. Our fundamentally new strategy combines and expands three relatively new complementary debugging approaches. The Stack Trace Analysis Tool (STAT), a 2011 R&D 100 Award Winner, identifies behavior equivalence classes in MPI jobs and highlights behavior when elements of the class demonstrate divergent behavior, often the first indicator of an error. The Cooperative Bug Isolation (CBI) project has developed statistical techniques for isolating programming errors in widely deployed code that we will adapt to large-scale parallel applications. Finally, we are developing a new approach to parallelizing expensive correctness analyses, such as analysis of memory usage in the Memgrind tool. In the first two

  2. Optimization techniques in statistics

    CERN Document Server

    Rustagi, Jagdish S

    1994-01-01

    Statistics help guide us to optimal decisions under uncertainty. A large variety of statistical problems are essentially solutions to optimization problems. The mathematical techniques of optimization are fundamentalto statistical theory and practice. In this book, Jagdish Rustagi provides full-spectrum coverage of these methods, ranging from classical optimization and Lagrange multipliers, to numerical techniques using gradients or direct search, to linear, nonlinear, and dynamic programming using the Kuhn-Tucker conditions or the Pontryagin maximal principle. Variational methods and optimiza

  3. Statistical Techniques for Project Control

    CERN Document Server

    Badiru, Adedeji B

    2012-01-01

    A project can be simple or complex. In each case, proven project management processes must be followed. In all cases of project management implementation, control must be exercised in order to assure that project objectives are achieved. Statistical Techniques for Project Control seamlessly integrates qualitative and quantitative tools and techniques for project control. It fills the void that exists in the application of statistical techniques to project control. The book begins by defining the fundamentals of project management then explores how to temper quantitative analysis with qualitati

  4. 21 CFR 820.250 - Statistical techniques.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Statistical techniques. 820.250 Section 820.250...) MEDICAL DEVICES QUALITY SYSTEM REGULATION Statistical Techniques § 820.250 Statistical techniques. (a... statistical techniques required for establishing, controlling, and verifying the acceptability of process...

  5. Land Subsidence Monitoring Using PS-InSAR Technique for L-Band SAR Data

    Science.gov (United States)

    Thapa, S.; Chatterjee, R. S.; Singh, K. B.; Kumar, D.

    2016-10-01

    Differential SAR-Interferometry (D-InSAR) is one of the potential source to measure land surface motion induced due to underground coal mining. However, this technique has many limitation such as atmospheric in homogeneities, spatial de-correlation, and temporal decorrelation. Persistent Scatterer Interferometry synthetic aperture radar (PS-InSAR) belongs to a family of time series InSAR technique, which utilizes the properties of some of the stable natural and anthropogenic targets which remain coherent over long time period. In this study PS-InSAR technique has been used to monitor land subsidence over selected location of Jharia Coal field which has been correlated with the ground levelling measurement. This time series deformation observed using PS InSAR helped us to understand the nature of the ground surface deformation due to underground mining activity.

  6. Statistically tuned Gaussian background subtraction technique for ...

    Indian Academy of Sciences (India)

    Sample videos of various properties such as cluttered background, small objects, moving background and multiple objects are considered for evaluation. The technique is statistically compared with frame differencing technique, temporal median method and mixture of Gaussian model and performance evaluation is done to ...

  7. Statistical and Computational Techniques in Manufacturing

    CERN Document Server

    2012-01-01

    In recent years, interest in developing statistical and computational techniques for applied manufacturing engineering has been increased. Today, due to the great complexity of manufacturing engineering and the high number of parameters used, conventional approaches are no longer sufficient. Therefore, in manufacturing, statistical and computational techniques have achieved several applications, namely, modelling and simulation manufacturing processes, optimization manufacturing parameters, monitoring and control, computer-aided process planning, etc. The present book aims to provide recent information on statistical and computational techniques applied in manufacturing engineering. The content is suitable for final undergraduate engineering courses or as a subject on manufacturing at the postgraduate level. This book serves as a useful reference for academics, statistical and computational science researchers, mechanical, manufacturing and industrial engineers, and professionals in industries related to manu...

  8. iPS cells generation: an overview of techniques and methods

    Directory of Open Access Journals (Sweden)

    Telpalo-Carpio SA

    2013-04-01

    Full Text Available Cell therapy is one of the principal and most promising research areas of regenerative medicine. Nevertheless different ethical problems related with the use of embryonic stem cells arise from this technology. Thus the search for a feasible way of stem cells generation is in current investigation. Induced pluripotent stem (iPS cell is one of the most encouraging emerging technologies that represent a solution to this problem. Different methods that change cell protein and gene profiles, as well as its morphology and function, driving the cell to the stem cell state have been developed. These include nuclear transfer, the usage of cell extracts and synthetic molecules, the forced expression of defined genes and cytoplasmatic level modifications. Even though favorable results have been achieved, there are still issues that require special attention. Advances with non-integration methods are now available but dedifferentiation efficiency is yet an area of opportunity. The main objective of this review is to show the most important techniques, their advantages and opportunity areas in the field of iPS cell generation.

  9. Statistical problems in design technique validation

    Energy Technology Data Exchange (ETDEWEB)

    Cohen, J.S.

    1980-04-01

    This work is concerned with the statistical validation process for measuring the accuracy of design techniques for solar energy systems. This includes a discussion of the statistical variability inherent in the design and measurement processes and the way in which this variability can dictate the choice of experimental design, choice of data, accuracy of the results, and choice of questions that can be reliably answered in such a study. The approach here is primarily concerned with design procedure validation in the context of the realistic process of system desig, where the discrepancy between measured and predicted results is due to limitations in the mathematical models employed by the procedures and the inaccuracies of input data. A set of guidelines for successful validation methodologies is discussed, and a simplified validation methodology for domestic hot water heaters is presented.

  10. A survey of statistical downscaling techniques

    Energy Technology Data Exchange (ETDEWEB)

    Zorita, E.; Storch, H. von [GKSS-Forschungszentrum Geesthacht GmbH (Germany). Inst. fuer Hydrophysik

    1997-12-31

    The derivation of regional information from integrations of coarse-resolution General Circulation Models (GCM) is generally referred to as downscaling. The most relevant statistical downscaling techniques are described here and some particular examples are worked out in detail. They are classified into three main groups: linear methods, classification methods and deterministic non-linear methods. Their performance in a particular example, winter rainfall in the Iberian peninsula, is compared to a simple downscaling analog method. It is found that the analog method performs equally well than the more complicated methods. Downscaling analysis can be also used as a tool to validate regional performance of global climate models by analyzing the covariability of the simulated large-scale climate and the regional climates. (orig.) [Deutsch] Die Ableitung regionaler Information aus Integrationen grob aufgeloester Klimamodelle wird als `Regionalisierung` bezeichnet. Dieser Beitrag beschreibt die wichtigsten statistischen Regionalisierungsverfahren und gibt darueberhinaus einige detaillierte Beispiele. Regionalisierungsverfahren lassen sich in drei Hauptgruppen klassifizieren: lineare Verfahren, Klassifikationsverfahren und nicht-lineare deterministische Verfahren. Diese Methoden werden auf den Niederschlag auf der iberischen Halbinsel angewandt und mit den Ergebnissen eines einfachen Analog-Modells verglichen. Es wird festgestellt, dass die Ergebnisse der komplizierteren Verfahren im wesentlichen auch mit der Analog-Methode erzielt werden koennen. Eine weitere Anwendung der Regionalisierungsmethoden besteht in der Validierung globaler Klimamodelle, indem die simulierte und die beobachtete Kovariabilitaet zwischen dem grosskaligen und dem regionalen Klima miteinander verglichen wird. (orig.)

  11. Statistical elaborations of PS DInSAR data applied to the analysis of the subsidence affecting the Venetian coast

    Science.gov (United States)

    Tessitore, Serena; Fiaschi, Simone; Achilli, Vladimiro; Fabris, Massimo; Floris, Mario

    2015-04-01

    Subsidence is a hazard that may have natural or anthropic origin. It can affect wide areas causing important economic losses. The area of the Venetian coast is affected by subsidence mainly due to the exploitation of its resources (gas and water). In particular, about 40% of the Italian extraction activities are on this area and here the subsidence arise in conjunction with the industrial revolution (1950-1970). An effective monitoring system is necessary for the correct management of the resources exploitation that, very often, is not supervised. To this aim, the innovative DInSAR techniques have been effectively employed as monitoring systems for the risk assessments of various instability phenomena, such as subsidence, landslides, volcanic eruptions, earthquakes, sinkholes. These techniques represent a powerful investigation tool for their high spatial and multi-temporal coverage, fast data acquisition, and overall low costs. Their results are the displacement estimates along the satellite Line of Sight (LOS), the velocity map and the displacements time series for the whole observation period. In the present work, the ERS and ENVISAT DInSAR data, achieved through the Persistent Scatterers (PS) technique, have been used to produce the iso-kinetic maps of deformation for an area of about 4300 Km2. Here, the mean velocities computed along the ERS and ENVISAT observation periods 1992-2000 and 2003-2010 have been interpolated through the Ordinary Kriging (OK) method. Simulated values and estimations of subsidence uncertainties have been analysed to advance the current understanding on the phenomenon that affects the study area. The achieved maps give information about the spatial distribution of the rates of deformation, which could be correlated with the available geological, hydrogeological and geotechnical data, as well as with the recorded damage to the structures and infrastructures. Then, local Authorities can use these maps as useful tools for the monitoring

  12. Statistical Techniques in Electrical and Computer Engineering

    Indian Academy of Sciences (India)

    Stochastic models and statistical inference from them have been popular methodologies in a variety of engineering disciplines, notably in electrical and computer engineering. Recent years have seen explosive growth in this area, driven by technological imperatives. These now go well beyond their traditional domain of ...

  13. Statistical normalization techniques for magnetic resonance imaging

    Directory of Open Access Journals (Sweden)

    Russell T. Shinohara

    2014-01-01

    Full Text Available While computed tomography and other imaging techniques are measured in absolute units with physical meaning, magnetic resonance images are expressed in arbitrary units that are difficult to interpret and differ between study visits and subjects. Much work in the image processing literature on intensity normalization has focused on histogram matching and other histogram mapping techniques, with little emphasis on normalizing images to have biologically interpretable units. Furthermore, there are no formalized principles or goals for the crucial comparability of image intensities within and across subjects. To address this, we propose a set of criteria necessary for the normalization of images. We further propose simple and robust biologically motivated normalization techniques for multisequence brain imaging that have the same interpretation across acquisitions and satisfy the proposed criteria. We compare the performance of different normalization methods in thousands of images of patients with Alzheimer's disease, hundreds of patients with multiple sclerosis, and hundreds of healthy subjects obtained in several different studies at dozens of imaging centers.

  14. Predicting radiotherapy outcomes using statistical learning techniques

    Energy Technology Data Exchange (ETDEWEB)

    El Naqa, Issam; Bradley, Jeffrey D; Deasy, Joseph O [Washington University, Saint Louis, MO (United States); Lindsay, Patricia E; Hope, Andrew J [Department of Radiation Oncology, Princess Margaret Hospital, Toronto, ON (Canada)

    2009-09-21

    Radiotherapy outcomes are determined by complex interactions between treatment, anatomical and patient-related variables. A common obstacle to building maximally predictive outcome models for clinical practice is the failure to capture potential complexity of heterogeneous variable interactions and applicability beyond institutional data. We describe a statistical learning methodology that can automatically screen for nonlinear relations among prognostic variables and generalize to unseen data before. In this work, several types of linear and nonlinear kernels to generate interaction terms and approximate the treatment-response function are evaluated. Examples of institutional datasets of esophagitis, pneumonitis and xerostomia endpoints were used. Furthermore, an independent RTOG dataset was used for 'generalizabilty' validation. We formulated the discrimination between risk groups as a supervised learning problem. The distribution of patient groups was initially analyzed using principle components analysis (PCA) to uncover potential nonlinear behavior. The performance of the different methods was evaluated using bivariate correlations and actuarial analysis. Over-fitting was controlled via cross-validation resampling. Our results suggest that a modified support vector machine (SVM) kernel method provided superior performance on leave-one-out testing compared to logistic regression and neural networks in cases where the data exhibited nonlinear behavior on PCA. For instance, in prediction of esophagitis and pneumonitis endpoints, which exhibited nonlinear behavior on PCA, the method provided 21% and 60% improvements, respectively. Furthermore, evaluation on the independent pneumonitis RTOG dataset demonstrated good generalizabilty beyond institutional data in contrast with other models. This indicates that the prediction of treatment response can be improved by utilizing nonlinear kernel methods for discovering important nonlinear interactions among

  15. Predicting radiotherapy outcomes using statistical learning techniques

    Science.gov (United States)

    El Naqa, Issam; Bradley, Jeffrey D.; Lindsay, Patricia E.; Hope, Andrew J.; Deasy, Joseph O.

    2009-09-01

    Radiotherapy outcomes are determined by complex interactions between treatment, anatomical and patient-related variables. A common obstacle to building maximally predictive outcome models for clinical practice is the failure to capture potential complexity of heterogeneous variable interactions and applicability beyond institutional data. We describe a statistical learning methodology that can automatically screen for nonlinear relations among prognostic variables and generalize to unseen data before. In this work, several types of linear and nonlinear kernels to generate interaction terms and approximate the treatment-response function are evaluated. Examples of institutional datasets of esophagitis, pneumonitis and xerostomia endpoints were used. Furthermore, an independent RTOG dataset was used for 'generalizabilty' validation. We formulated the discrimination between risk groups as a supervised learning problem. The distribution of patient groups was initially analyzed using principle components analysis (PCA) to uncover potential nonlinear behavior. The performance of the different methods was evaluated using bivariate correlations and actuarial analysis. Over-fitting was controlled via cross-validation resampling. Our results suggest that a modified support vector machine (SVM) kernel method provided superior performance on leave-one-out testing compared to logistic regression and neural networks in cases where the data exhibited nonlinear behavior on PCA. For instance, in prediction of esophagitis and pneumonitis endpoints, which exhibited nonlinear behavior on PCA, the method provided 21% and 60% improvements, respectively. Furthermore, evaluation on the independent pneumonitis RTOG dataset demonstrated good generalizabilty beyond institutional data in contrast with other models. This indicates that the prediction of treatment response can be improved by utilizing nonlinear kernel methods for discovering important nonlinear interactions among model

  16. "Statistical Techniques for Particle Physics" (3/4)

    CERN Multimedia

    CERN. Geneva

    2009-01-01

    This series will consist of four 1-hour lectures on statistics for particle physics. The goal will be to build up to techniques meant for dealing with problems of realistic complexity while maintaining a formal approach. I will also try to incorporate usage of common tools like ROOT, RooFit, and the newly developed RooStats framework into the lectures. The first lecture will begin with a review the basic principles of probability, some terminology, and the three main approaches towards statistical inference (Frequentist, Bayesian, and Likelihood-based). I will then outline the statistical basis for multivariate analysis techniques (the Neyman-Pearson lemma) and the motivation for machine learning algorithms. Later, I will extend simple hypothesis testing to the case in which the statistical model has one or many parameters (the Neyman Construction and the Feldman-Cousins technique). From there I will outline techniques to incorporate background uncertainties. If time allows, I will touch on the statist...

  17. "Statistical Techniques for Particle Physics" (2/4)

    CERN Multimedia

    CERN. Geneva

    2009-01-01

    This series will consist of four 1-hour lectures on statistics for particle physics. The goal will be to build up to techniques meant for dealing with problems of realistic complexity while maintaining a formal approach. I will also try to incorporate usage of common tools like ROOT, RooFit, and the newly developed RooStats framework into the lectures. The first lecture will begin with a review the basic principles of probability, some terminology, and the three main approaches towards statistical inference (Frequentist, Bayesian, and Likelihood-based). I will then outline the statistical basis for multivariate analysis techniques (the Neyman-Pearson lemma) and the motivation for machine learning algorithms. Later, I will extend simple hypothesis testing to the case in which the statistical model has one or many parameters (the Neyman Construction and the Feldman-Cousins technique). From there I will outline techniques to incorporate background uncertainties. If time allows, I will touch on the statist...

  18. "Statistical Techniques for Particle Physics" (4/4)

    CERN Multimedia

    CERN. Geneva

    2009-01-01

    This series will consist of four 1-hour lectures on statistics for particle physics. The goal will be to build up to techniques meant for dealing with problems of realistic complexity while maintaining a formal approach. I will also try to incorporate usage of common tools like ROOT, RooFit, and the newly developed RooStats framework into the lectures. The first lecture will begin with a review the basic principles of probability, some terminology, and the three main approaches towards statistical inference (Frequentist, Bayesian, and Likelihood-based). I will then outline the statistical basis for multivariate analysis techniques (the Neyman-Pearson lemma) and the motivation for machine learning algorithms. Later, I will extend simple hypothesis testing to the case in which the statistical model has one or many parameters (the Neyman Construction and the Feldman-Cousins technique). From there I will outline techniques to incorporate background uncertainties. If time allows, I will touch on the statist...

  19. "Statistical Techniques for Particle Physics" (1/4)

    CERN Multimedia

    CERN. Geneva

    2009-01-01

    This series will consist of four 1-hour lectures on statistics for particle physics. The goal will be to build up to techniques meant for dealing with problems of realistic complexity while maintaining a formal approach. I will also try to incorporate usage of common tools like ROOT, RooFit, and the newly developed RooStats framework into the lectures. The first lecture will begin with a review the basic principles of probability, some terminology, and the three main approaches towards statistical inference (Frequentist, Bayesian, and Likelihood-based). I will then outline the statistical basis for multivariate analysis techniques (the Neyman-Pearson lemma) and the motivation for machine learning algorithms. Later, I will extend simple hypothesis testing to the case in which the statistical model has one or many parameters (the Neyman Construction and the Feldman-Cousins technique). From there I will outline techniques to incorporate background uncertainties. If time allows, I will touch on the statist...

  20. Using statistical quality control techniques to monitor blood glucose levels.

    OpenAIRE

    Oniki, T. A.; Clemmer, T. P.; Arthur, L. K.; Linford, L.H.

    1995-01-01

    Continuous Quality Improvement techniques developed in industry are increasingly being applied to the medical field. Statistical process control charts are a CQI technique aimed at monitoring a process and its variability. At our hospital, statistical quality control charts are being constructed from laboratory blood glucose measurements of patients receiving enteral or parenteral nutrition. The charts will be used to monitor glucose levels, reveal variations, and illustrate the effects of ne...

  1. Adaptive Filtering Technique and Comparison of PS25015A Dry Electrodes and Two Different Ag/AgCl Wet Electrodes for Wearable ECG Applications

    Directory of Open Access Journals (Sweden)

    Nika ZOLFAGHARI

    2015-01-01

    Full Text Available The electrocardiogram (ECG is one of the most important signals acquired from the body, as it serves as the immediate source of information relating to heart performance. Hence, a lot of research has gone into various types of ECG acquisition methods and systems. With the numerous methods and systems available at hand, it is important to compare, contrast, and evaluate the existing techniques. Not only does this help distinguish between the different techniques, it also helps build on the existing methods to create successful acquisition systems that can surpass the effect of unwanted factors, such as movement and other noise artifacts. This paper builds on a previous study that compared two different ECG acquisition systems, one of which uses PS25015A dry electrodes and the other, which uses two different silver/silver chloride (Ag/AgCl wet electrodes. The adaptive filtering technique was implemented in order to test its effectiveness when applied to a wearable ECG medical device, intended to monitor the user’s ECG throughout daily activities, such as walking. According to statistical analysis, the dry electrodes may have a better SNR. However, the dry electrodes provided a lower wave amplitude, compared to the wet electrodes. Overall, the least mean squares (LMS adaptive filtering, along with bandpass filtering, helped reduce motion artifacts in ECG signals acquired during walking.

  2. Statistical Tropical Cyclone Forecasting Techniques for the Southern Hemisphere.

    Science.gov (United States)

    1984-06-01

    TR 84-D7 We, STATISTICAL TROPICAL CYCLONE * FORECASTING TECHNIQUES FOR THE SOUTHERN HEMISPHERE C. Thomas 0. Keenan I, Bureau of Meteorology -c...NOTES : , *Author’s affiliation: Synoptic Research Section, Bureau of Meteorology , Melbourne, Australia. Research documented in TR 84-07 was performed...Techniques The Australian techniques were developed at the Bureau of Meteorology , Australia for use in the Australian area of fore- casting

  3. Montecarlo Techniques as a tool for teaching statistics

    CERN Document Server

    Bueno, FM Alexander

    2014-01-01

    Probability Theory and Statistics are two of the most useful mathematical fields, and also two of the most difficult to learn. In other science fields, as Physics, experimentation is an useful tool to develop students intuition, but the application of this tool to Statistics is much more difficult. In this paper we show how Monte Carlo techniques can be used to perform numerical experiments, by the use of pseudorandom numbers, and how these experiments can help to the understanding of Statistics and Physics. Monte Carlo techniques are broadly used in scientific research, but they are learnt usually in very specific curses of higher education. By the use of computer simulation these techniques can also be taught at elementary school and they can help to understand and visualise concepts as variance, mean or a probability distribution function. Finally, the use of new technologies, as Javascript and HTML is discussed.

  4. A simple solvent blending coupled sonication technique for synthesis of polystyrene (PS/multi-walled carbon nanotube (MWCNT nanocomposites: Effect of modified MWCNT content

    Directory of Open Access Journals (Sweden)

    Payel Sen

    2016-09-01

    Full Text Available The influence of carboxylic acid functionalized multi-walled carbon nanotubes (cMWCNTs content on the properties of polystyrene (PS nanocomposite (NC films was investigated. The NC films were produced by a simple sonication assisted solvent blending technique. The interaction between the matrix (PS and well dispersed filler (cMWCNT was evaluated by different techniques involving Fourier transform infrared spectroscopy, Raman spectroscopy and X-Ray diffraction. Morphological images of the NCs were collected from Transmission electron microscopy. The thermal characteristics of the PS were found to be improved by the incorporation of the cMWCNTs, which was evident from the Thermogravimetric analysis (TGA data. The thermal degradation activation energy evaluated by Coats-Redfern method and integral procedural decomposition temperature determined by Doyle's method supported the thermal stability proposed by TGA of the NCs. The reaction mechanism of thermal degradation of neat PS and respective NCs was successfully predicted using Criado method. The rheological properties and hardness were found to be upgraded by the inclusion of nanotubes to the PS matrix.

  5. Review of the Statistical Techniques in Medical Sciences | Okeh ...

    African Journals Online (AJOL)

    Medical scientists often times are faced with the need to choose the right statistical technique for a given set of data. There are a number of criteria that should be a guide in making the right choice: the research questions, the category of the variables involved the size of the sample, the scale of measurement of the variable, ...

  6. Validation of Models : Statistical Techniques and Data Availability

    NARCIS (Netherlands)

    Kleijnen, J.P.C.

    1999-01-01

    This paper shows which statistical techniques can be used to validate simulation models, depending on which real-life data are available. Concerning this availability three situations are distinguished (i) no data, (ii) only output data, and (iii) both input and output data. In case (i) - no real

  7. Lightweight and Statistical Techniques for Petascale PetaScale Debugging

    Energy Technology Data Exchange (ETDEWEB)

    Miller, Barton

    2014-06-30

    This project investigated novel techniques for debugging scientific applications on petascale architectures. In particular, we developed lightweight tools that narrow the problem space when bugs are encountered. We also developed techniques that either limit the number of tasks and the code regions to which a developer must apply a traditional debugger or that apply statistical techniques to provide direct suggestions of the location and type of error. We extend previous work on the Stack Trace Analysis Tool (STAT), that has already demonstrated scalability to over one hundred thousand MPI tasks. We also extended statistical techniques developed to isolate programming errors in widely used sequential or threaded applications in the Cooperative Bug Isolation (CBI) project to large scale parallel applications. Overall, our research substantially improved productivity on petascale platforms through a tool set for debugging that complements existing commercial tools. Previously, Office Of Science application developers relied either on primitive manual debugging techniques based on printf or they use tools, such as TotalView, that do not scale beyond a few thousand processors. However, bugs often arise at scale and substantial effort and computation cycles are wasted in either reproducing the problem in a smaller run that can be analyzed with the traditional tools or in repeated runs at scale that use the primitive techniques. New techniques that work at scale and automate the process of identifying the root cause of errors were needed. These techniques significantly reduced the time spent debugging petascale applications, thus leading to a greater overall amount of time for application scientists to pursue the scientific objectives for which the systems are purchased. We developed a new paradigm for debugging at scale: techniques that reduced the debugging scenario to a scale suitable for traditional debuggers, e.g., by narrowing the search for the root-cause analysis

  8. Statistical and Economic Techniques for Site-specific Nematode Management.

    Science.gov (United States)

    Liu, Zheng; Griffin, Terry; Kirkpatrick, Terrence L

    2014-03-01

    Recent advances in precision agriculture technologies and spatial statistics allow realistic, site-specific estimation of nematode damage to field crops and provide a platform for the site-specific delivery of nematicides within individual fields. This paper reviews the spatial statistical techniques that model correlations among neighboring observations and develop a spatial economic analysis to determine the potential of site-specific nematicide application. The spatial econometric methodology applied in the context of site-specific crop yield response contributes to closing the gap between data analysis and realistic site-specific nematicide recommendations and helps to provide a practical method of site-specifically controlling nematodes.

  9. Categorical and nonparametric data analysis choosing the best statistical technique

    CERN Document Server

    Nussbaum, E Michael

    2014-01-01

    Featuring in-depth coverage of categorical and nonparametric statistics, this book provides a conceptual framework for choosing the most appropriate type of test in various research scenarios. Class tested at the University of Nevada, the book's clear explanations of the underlying assumptions, computer simulations, and Exploring the Concept boxes help reduce reader anxiety. Problems inspired by actual studies provide meaningful illustrations of the techniques. The underlying assumptions of each test and the factors that impact validity and statistical power are reviewed so readers can explain

  10. Detection by voxel-wise statistical analysis of significant changes in regional cerebral glucose uptake in an APP/PS1 transgenic mouse model of Alzheimer's disease.

    Science.gov (United States)

    Dubois, Albertine; Hérard, Anne-Sophie; Delatour, Benoît; Hantraye, Philippe; Bonvento, Gilles; Dhenain, Marc; Delzescaux, Thierry

    2010-06-01

    Biomarkers and technologies similar to those used in humans are essential for the follow-up of Alzheimer's disease (AD) animal models, particularly for the clarification of mechanisms and the screening and validation of new candidate treatments. In humans, changes in brain metabolism can be detected by 1-deoxy-2-[(18)F] fluoro-D-glucose PET (FDG-PET) and assessed in a user-independent manner with dedicated software, such as Statistical Parametric Mapping (SPM). FDG-PET can be carried out in small animals, but its resolution is low as compared to the size of rodent brain structures. In mouse models of AD, changes in cerebral glucose utilization are usually detected by [(14)C]-2-deoxyglucose (2DG) autoradiography, but this requires prior manual outlining of regions of interest (ROI) on selected sections. Here, we evaluate the feasibility of applying the SPM method to 3D autoradiographic data sets mapping brain metabolic activity in a transgenic mouse model of AD. We report the preliminary results obtained with 4 APP/PS1 (64+/-1 weeks) and 3 PS1 (65+/-2 weeks) mice. We also describe new procedures for the acquisition and use of "blockface" photographs and provide the first demonstration of their value for the 3D reconstruction and spatial normalization of post mortem mouse brain volumes. Despite this limited sample size, our results appear to be meaningful, consistent, and more comprehensive than findings from previously published studies based on conventional ROI-based methods. The establishment of statistical significance at the voxel level, rather than with a user-defined ROI, makes it possible to detect more reliably subtle differences in geometrically complex regions, such as the hippocampus. Our approach is generic and could be easily applied to other biomarkers and extended to other species and applications. Copyright 2010 Elsevier Inc. All rights reserved.

  11. The applications of statistical quantification techniques in nanomechanics and nanoelectronics.

    Science.gov (United States)

    Mai, Wenjie; Deng, Xinwei

    2010-10-08

    Although nanoscience and nanotechnology have been developing for approximately two decades and have achieved numerous breakthroughs, the experimental results from nanomaterials with a higher noise level and poorer repeatability than those from bulk materials still remain as a practical issue, and challenge many techniques of quantification of nanomaterials. This work proposes a physical-statistical modeling approach and a global fitting statistical method to use all the available discrete data or quasi-continuous curves to quantify a few targeted physical parameters, which can provide more accurate, efficient and reliable parameter estimates, and give reasonable physical explanations. In the resonance method for measuring the elastic modulus of ZnO nanowires (Zhou et al 2006 Solid State Commun. 139 222-6), our statistical technique gives E = 128.33 GPa instead of the original E = 108 GPa, and unveils a negative bias adjustment f(0). The causes are suggested by the systematic bias in measuring the length of the nanowires. In the electronic measurement of the resistivity of a Mo nanowire (Zach et al 2000 Science 290 2120-3), the proposed new method automatically identified the importance of accounting for the Ohmic contact resistance in the model of the Ohmic behavior in nanoelectronics experiments. The 95% confidence interval of resistivity in the proposed one-step procedure is determined to be 3.57 +/- 0.0274 x 10( - 5) ohm cm, which should be a more reliable and precise estimate. The statistical quantification technique should find wide applications in obtaining better estimations from various systematic errors and biased effects that become more significant at the nanoscale.

  12. The applications of statistical quantification techniques in nanomechanics and nanoelectronics

    Science.gov (United States)

    Mai, Wenjie; Deng, Xinwei

    2010-10-01

    Although nanoscience and nanotechnology have been developing for approximately two decades and have achieved numerous breakthroughs, the experimental results from nanomaterials with a higher noise level and poorer repeatability than those from bulk materials still remain as a practical issue, and challenge many techniques of quantification of nanomaterials. This work proposes a physical-statistical modeling approach and a global fitting statistical method to use all the available discrete data or quasi-continuous curves to quantify a few targeted physical parameters, which can provide more accurate, efficient and reliable parameter estimates, and give reasonable physical explanations. In the resonance method for measuring the elastic modulus of ZnO nanowires (Zhou et al 2006 Solid State Commun. 139 222-6), our statistical technique gives E = 128.33 GPa instead of the original E = 108 GPa, and unveils a negative bias adjustment f0. The causes are suggested by the systematic bias in measuring the length of the nanowires. In the electronic measurement of the resistivity of a Mo nanowire (Zach et al 2000 Science 290 2120-3), the proposed new method automatically identified the importance of accounting for the Ohmic contact resistance in the model of the Ohmic behavior in nanoelectronics experiments. The 95% confidence interval of resistivity in the proposed one-step procedure is determined to be 3.57 ± 0.0274 × 10 - 5 ohm cm, which should be a more reliable and precise estimate. The statistical quantification technique should find wide applications in obtaining better estimations from various systematic errors and biased effects that become more significant at the nanoscale.

  13. Application of multivariate statistical techniques in microbial ecology.

    Science.gov (United States)

    Paliy, O; Shankar, V

    2016-03-01

    Recent advances in high-throughput methods of molecular analyses have led to an explosion of studies generating large-scale ecological data sets. In particular, noticeable effect has been attained in the field of microbial ecology, where new experimental approaches provided in-depth assessments of the composition, functions and dynamic changes of complex microbial communities. Because even a single high-throughput experiment produces large amount of data, powerful statistical techniques of multivariate analysis are well suited to analyse and interpret these data sets. Many different multivariate techniques are available, and often it is not clear which method should be applied to a particular data set. In this review, we describe and compare the most widely used multivariate statistical techniques including exploratory, interpretive and discriminatory procedures. We consider several important limitations and assumptions of these methods, and we present examples of how these approaches have been utilized in recent studies to provide insight into the ecology of the microbial world. Finally, we offer suggestions for the selection of appropriate methods based on the research question and data set structure. © 2016 John Wiley & Sons Ltd.

  14. Statistical Techniques for Assessing water‐quality effects of BMPs

    Science.gov (United States)

    Walker, John F.

    1994-01-01

    Little has been published on the effectiveness of various management practices in small rural lakes and streams at the watershed scale. In this study, statistical techniques were used to test for changes in water‐quality data from watersheds where best management practices (BMPs) were implemented. Reductions in data variability due to climate and seasonality were accomplished through the use of regression methods. This study discusses the merits of using storm‐mass‐transport data as a means of improving the ability to detect BMP effects on stream‐water quality. Statistical techniques were applied to suspended‐sediment records from three rural watersheds in Illinois for the period 1981–84. None of the techniques identified changes in suspended sediment, primarily because of the small degree of BMP implementation and because of potential errors introduced through the estimation of storm‐mass transport. A Monte Carlo sensitivity analysis was used to determine the level of discrete change that could be detected for each watershed. In all cases, the use of regressions improved the ability to detect trends.Read More: http://ascelibrary.org/doi/abs/10.1061/(ASCE)0733-9437(1994)120:2(334)

  15. Statistics and Machine Learning based Outlier Detection Techniques for Exoplanets

    Science.gov (United States)

    Goel, Amit; Montgomery, Michele

    2015-08-01

    Architectures of planetary systems are observable snapshots in time that can indicate formation and dynamic evolution of planets. The observable key parameters that we consider are planetary mass and orbital period. If planet masses are significantly less than their host star masses, then Keplerian Motion is defined as P^2 = a^3 where P is the orbital period in units of years and a is the orbital period in units of Astronomical Units (AU). Keplerian motion works on small scales such as the size of the Solar System but not on large scales such as the size of the Milky Way Galaxy. In this work, for confirmed exoplanets of known stellar mass, planetary mass, orbital period, and stellar age, we analyze Keplerian motion of systems based on stellar age to seek if Keplerian motion has an age dependency and to identify outliers. For detecting outliers, we apply several techniques based on statistical and machine learning methods such as probabilistic, linear, and proximity based models. In probabilistic and statistical models of outliers, the parameters of a closed form probability distributions are learned in order to detect the outliers. Linear models use regression analysis based techniques for detecting outliers. Proximity based models use distance based algorithms such as k-nearest neighbour, clustering algorithms such as k-means, or density based algorithms such as kernel density estimation. In this work, we will use unsupervised learning algorithms with only the proximity based models. In addition, we explore the relative strengths and weaknesses of the various techniques by validating the outliers. The validation criteria for the outliers is if the ratio of planetary mass to stellar mass is less than 0.001. In this work, we present our statistical analysis of the outliers thus detected.

  16. Luminescent microstructures in bulk and thin films of PMMA, PDMS, PVA, and PS fabricated using femtosecond direct writing technique

    Science.gov (United States)

    Deepak, K. L. N.; Kuladeep, R.; Venugopal Rao, S.; Narayana Rao, D.

    2011-02-01

    We present here the luminescent properties of microstructures obtained through femtosecond (fs) laser direct writing (LDW) in bulk, and thin films of polymers such as poly methyl methacrylate (PMMA), poly dimethyl siloxane (PDMS), polystyrene (PS), and poly vinyl alcohol (PVA). We report the transmission, emission, excitation, laser confocal and ESR data from the modified regions acquired with the intention of understanding the fs irradiation effects in these polymers. Formation of different optical centers in the laser irradiated regions has been identified as the reason for emission characteristics which are dependent on the excitation source. Such emitting microstructures demonstrate their utility in memory based devices. ESR studies reveal the existence of peroxide type free radicals in PMMA, PDMS and PS after fs laser irradiation.

  17. Challenges in identifying asthma subgroups using unsupervised statistical learning techniques.

    Science.gov (United States)

    Prosperi, Mattia C F; Sahiner, Umit M; Belgrave, Danielle; Sackesen, Cansin; Buchan, Iain E; Simpson, Angela; Yavuz, Tolga S; Kalayci, Omer; Custovic, Adnan

    2013-12-01

    Unsupervised statistical learning techniques, such as exploratory factor analysis (EFA) and hierarchical clustering (HC), have been used to identify asthma phenotypes, with partly consistent results. Some of the inconsistency is caused by the variable selection and demographic and clinical differences among study populations. To investigate the effects of the choice of statistical method and different preparations of data on the clustering results; and to relate these to disease severity. Several variants of EFA and HC were applied and compared using various sets of variables and different encodings and transformations within a dataset of 383 children with asthma. Variables included lung function, inflammatory and allergy markers, family history, environmental exposures, and medications. Clusters and original variables were related to asthma severity (logistic regression and Bayesian network analysis). EFA identified five components (eigenvalues ≥ 1) explaining 35% of the overall variance. Variations of the HC (as linkage-distance functions) did not affect the cluster inference; however, using different variable encodings and transformations did. The derived clusters predicted asthma severity less than the original variables. Prognostic factors of severity were medication usage, current symptoms, lung function, paternal asthma, body mass index, and age of asthma onset. Bayesian networks indicated conditional dependence among variables. The use of different unsupervised statistical learning methods and different variable sets and encodings can lead to multiple and inconsistent subgroupings of asthma, not necessarily correlated with severity. The search for asthma phenotypes needs more careful selection of markers, consistent across different study populations, and more cautious interpretation of results from unsupervised learning.

  18. Direct generation of 2-ps blue pulses from gain-switched InGaN VCSEL assessed by up-conversion technique.

    Science.gov (United States)

    Asahara, Akifumi; Chen, Shaoqiang; Ito, Takashi; Yoshita, Masahiro; Liu, Wenjie; Zhang, Baoping; Suemoto, Tohru; Akiyama, Hidefumi

    2014-09-19

    Ultra-short pulses in blue region generated from compact and low-cost semiconductor lasers have attracted much attention for a wide variety of applications. Nitride-based vertical-cavity surface-emitting lasers (VCSELs), having intrinsic high material gain and short cavities, favor the generation of ultra-short blue pulses via a simple gain-switching technique. In this study, we fabricated a single-mode InGaN VCSEL consisting of 10-period InGaN/GaN quantum wells (QWs). The output pulses were evaluated accurately with an up-conversion measurement system having time resolution of 0.12 ps. We demonstrated that ultra-short blue pulses, as short as 2.2 ps at 3.4 K and 4.0 ps at room temperature, were generated from the gain-switched InGaN VCSEL via impulsive optical pumping, without any post-processing. The gain-switched pulses we obtained should greatly promote the development of ultra-short blue pulse generation. In addition, this successful assessment demonstrates the up-conversion technique's usefulness for characterizing ultra-short blue pulses from semiconductor lasers.

  19. Validation and Test-Retest Reliability of New Thermographic Technique Called Thermovision Technique of Dry Needling for Gluteus Minimus Trigger Points in Sciatica Subjects and TrPs-Negative Healthy Volunteers

    Science.gov (United States)

    Rychlik, Michał; Samborski, Włodzimierz

    2015-01-01

    The aim of this study was to assess the validity and test-retest reliability of Thermovision Technique of Dry Needling (TTDN) for the gluteus minimus muscle. TTDN is a new thermography approach used to support trigger points (TrPs) diagnostic criteria by presence of short-term vasomotor reactions occurring in the area where TrPs refer pain. Method. Thirty chronic sciatica patients (n=15 TrP-positive and n=15 TrPs-negative) and 15 healthy volunteers were evaluated by TTDN three times during two consecutive days based on TrPs of the gluteus minimus muscle confirmed additionally by referred pain presence. TTDN employs average temperature (T avr), maximum temperature (T max), low/high isothermal-area, and autonomic referred pain phenomenon (AURP) that reflects vasodilatation/vasoconstriction. Validity and test-retest reliability were assessed concurrently. Results. Two components of TTDN validity and reliability, T avr and AURP, had almost perfect agreement according to κ (e.g., thigh: 0.880 and 0.938; calf: 0.902 and 0.956, resp.). The sensitivity for T avr, T max, AURP, and high isothermal-area was 100% for everyone, but specificity of 100% was for T avr and AURP only. Conclusion. TTDN is a valid and reliable method for T avr and AURP measurement to support TrPs diagnostic criteria for the gluteus minimus muscle when digitally evoked referred pain pattern is present. PMID:26137486

  20. Validation and Test-Retest Reliability of New Thermographic Technique Called Thermovision Technique of Dry Needling for Gluteus Minimus Trigger Points in Sciatica Subjects and TrPs-Negative Healthy Volunteers

    Directory of Open Access Journals (Sweden)

    Elżbieta Skorupska

    2015-01-01

    Full Text Available The aim of this study was to assess the validity and test-retest reliability of Thermovision Technique of Dry Needling (TTDN for the gluteus minimus muscle. TTDN is a new thermography approach used to support trigger points (TrPs diagnostic criteria by presence of short-term vasomotor reactions occurring in the area where TrPs refer pain. Method. Thirty chronic sciatica patients (n=15 TrP-positive and n=15 TrPs-negative and 15 healthy volunteers were evaluated by TTDN three times during two consecutive days based on TrPs of the gluteus minimus muscle confirmed additionally by referred pain presence. TTDN employs average temperature (Tavr, maximum temperature (Tmax, low/high isothermal-area, and autonomic referred pain phenomenon (AURP that reflects vasodilatation/vasoconstriction. Validity and test-retest reliability were assessed concurrently. Results. Two components of TTDN validity and reliability, Tavr and AURP, had almost perfect agreement according to κ (e.g., thigh: 0.880 and 0.938; calf: 0.902 and 0.956, resp.. The sensitivity for Tavr, Tmax, AURP, and high isothermal-area was 100% for everyone, but specificity of 100% was for Tavr and AURP only. Conclusion. TTDN is a valid and reliable method for Tavr and AURP measurement to support TrPs diagnostic criteria for the gluteus minimus muscle when digitally evoked referred pain pattern is present.

  1. Generation of the SCN1A epilepsy mutation in hiPS cells using the TALEN technique

    Science.gov (United States)

    Chen, Wanjuan; Liu, Jingxin; Zhang, Longmei; Xu, Huijuan; Guo, Xiaogang; Deng, Sihao; Liu, Lipeng; Yu, Daiguan; Chen, Yonglong; Li, Zhiyuan

    2014-06-01

    Human induced pluripotent stem cells (iPSC) can be used to understand the pathological mechanisms of human disease. These cells are a promising source for cell-replacement therapy. However, such studies require genetically defined conditions. Such genetic manipulations can be performed using the novel Transcription Activator-Like Effector Nucleases (TALENs), which generate site-specific double-strand DNA breaks (DSBs) with high efficiency and precision. Combining the TALEN and iPSC methods, we developed two iPS cell lines by generating the point mutation A5768G in the SCN1A gene, which encodes the voltage-gated sodium channel Nav1.1 α subunit. The engineered iPSC maintained pluripotency and successfully differentiated into neurons with normal functional characteristics. The two cell lines differ exclusively at the epilepsy-susceptibility variant. The ability to robustly introduce disease-causing point mutations in normal hiPS cell lines can be used to generate a human cell model for studying epileptic mechanisms and for drug screening.

  2. Statistical technique for analysing functional connectivity of multiple spike trains.

    Science.gov (United States)

    Masud, Mohammad Shahed; Borisyuk, Roman

    2011-03-15

    A new statistical technique, the Cox method, used for analysing functional connectivity of simultaneously recorded multiple spike trains is presented. This method is based on the theory of modulated renewal processes and it estimates a vector of influence strengths from multiple spike trains (called reference trains) to the selected (target) spike train. Selecting another target spike train and repeating the calculation of the influence strengths from the reference spike trains enables researchers to find all functional connections among multiple spike trains. In order to study functional connectivity an "influence function" is identified. This function recognises the specificity of neuronal interactions and reflects the dynamics of postsynaptic potential. In comparison to existing techniques, the Cox method has the following advantages: it does not use bins (binless method); it is applicable to cases where the sample size is small; it is sufficiently sensitive such that it estimates weak influences; it supports the simultaneous analysis of multiple influences; it is able to identify a correct connectivity scheme in difficult cases of "common source" or "indirect" connectivity. The Cox method has been thoroughly tested using multiple sets of data generated by the neural network model of the leaky integrate and fire neurons with a prescribed architecture of connections. The results suggest that this method is highly successful for analysing functional connectivity of simultaneously recorded multiple spike trains. Copyright © 2011 Elsevier B.V. All rights reserved.

  3. Statistical Performance Analysis and Modeling Techniques for Nanometer VLSI Designs

    CERN Document Server

    Shen, Ruijing; Yu, Hao

    2012-01-01

    Since process variation and chip performance uncertainties have become more pronounced as technologies scale down into the nanometer regime, accurate and efficient modeling or characterization of variations from the device to the architecture level have  become imperative for the successful design of VLSI chips. This book provides readers with tools for variation-aware design methodologies and computer-aided design (CAD) of VLSI systems, in the presence of process variations at the nanometer scale. It presents the latest developments for modeling and analysis, with a focus on statistical interconnect modeling, statistical parasitic extractions, statistical full-chip leakage and dynamic power analysis considering spatial correlations, statistical analysis and modeling for large global interconnects and analog/mixed-signal circuits.  Provides readers with timely, systematic and comprehensive treatments of statistical modeling and analysis of VLSI systems with a focus on interconnects, on-chip power grids and ...

  4. GIS-based bivariate statistical techniques for groundwater potential ...

    Indian Academy of Sciences (India)

    Ali Haghizadeh

    2017-11-23

    % and 23.74% of the study area is covered by ... Groundwater; statistical index; Dempster–Shafer theory; water resource management; GIS. 1. Introduction ... Positioning System (GPS), and Remote Sensing. (RS) (Srivastava ...

  5. TECHNIQUE OF THE STATISTICAL ANALYSIS OF INVESTMENT APPEAL OF THE REGION

    Directory of Open Access Journals (Sweden)

    А. А. Vershinina

    2014-01-01

    Full Text Available The technique of the statistical analysis of investment appeal of the region is given in scientific article for direct foreign investments. Definition of a technique of the statistical analysis is given, analysis stages reveal, the mathematico-statistical tools are considered.

  6. Sensitivity analysis and related analysis : A survey of statistical techniques

    NARCIS (Netherlands)

    Kleijnen, J.P.C.

    1995-01-01

    This paper reviews the state of the art in five related types of analysis, namely (i) sensitivity or what-if analysis, (ii) uncertainty or risk analysis, (iii) screening, (iv) validation, and (v) optimization. The main question is: when should which type of analysis be applied; which statistical

  7. New Dynamical-Statistical Techniques for Wind Power Prediction

    Science.gov (United States)

    Stathopoulos, C.; Kaperoni, A.; Galanis, G.; Kallos, G.

    2012-04-01

    The increased use of renewable energy sources, and especially of wind power, has revealed the significance of accurate environmental and wind power predictions over wind farms that critically affect the integration of the produced power in the general grid. This issue is studied in the present paper by means of high resolution physical and statistical models. Two numerical weather prediction (NWP) systems namely SKIRON and RAMS are used to simulate the flow characteristics in selected wind farms in Greece. The NWP model output is post-processed by utilizing Kalman and Kolmogorov statistics in order to remove systematic errors. Modeled wind predictions in combination with available on-site observations are used for estimation of the wind power potential by utilizing a variety of statistical power prediction models based on non-linear and hyperbolic functions. The obtained results reveal the strong dependence of the forecasts uncertainty on the wind variation, the limited influence of previously recorded power values and the advantages that nonlinear - non polynomial functions could have in the successful control of power curve characteristics. This methodology is developed at the framework of the FP7 projects WAUDIT and MARINA PLATFORM.

  8. Understanding Summary Statistics and Graphical Techniques to Compare Michael Jordan versus LeBron James

    Science.gov (United States)

    Williams, Immanuel James; Williams, Kelley Kim

    2016-01-01

    Understanding summary statistics and graphical techniques are building blocks to comprehending concepts beyond basic statistics. It's known that motivated students perform better in school. Using examples that students find engaging allows them to understand the concepts at a deeper level.

  9. GIS-Based bivariate statistical techniques for groundwater potential ...

    Indian Academy of Sciences (India)

    24

    these models are known as computational intelligence and machine learning techniques to use for replacing .... (NCC) using topography survey base points displaying showing the elevation altitude values which were ... lithology of an given area and affect the drainage density and can be of great big value for to evaluate ...

  10. Statistical Theory of the Vector Random Decrement Technique

    DEFF Research Database (Denmark)

    Asmussen, J. C.; Brincker, Rune; Ibrahim, S. R.

    1999-01-01

    The Vector Random Decrement technique has previously been introduced as an effcient method to transform ambient responses of linear structures into Vector Random Decrement functions which are equivalent to free decays of the current structure. The modal parameters can be extracted from the free...

  11. On the crystallization behavior of syndiotactic-b-atactic polystyrene stereodiblock copolymers, atactic/syndiotactic polystyrene blends, and aPS/sPS blends modified with sPS-b-aPS

    Energy Technology Data Exchange (ETDEWEB)

    Annunziata, Liana, E-mail: liana.annunziatta@univ-rennes1.fr [Organométalliques et Catalyse, UMR 6226 Sciences Chimiques CNRS, Université de Rennes 1, Campus de Beaulieu, F-35042 Rennes Cedex (France); Monasse, Bernard, E-mail: bernard.monasse@mines-paristech.fr [Mines-ParisTech, CEMEF, Centre de Mise en Forme des Matériaux, UMR CNRS 7635, Sophia Antipolis (France); Rizzo, Paola; Guerra, Gaetano [Dipartimento di Chimica e Biologia, Università degli studi di Salerno, Via Ponte don Melillo, I-84084 Fisciano, SA (Italy); Duc, Michel [Total Petrochemicals Research Feluy, Zone Industrielle Feluy C, B-7181 Seneffe (Belgium); Carpentier, Jean-François, E-mail: jean-francois.carpentier@univ-rennes1.fr [Organométalliques et Catalyse, UMR 6226 Sciences Chimiques CNRS, Université de Rennes 1, Campus de Beaulieu, F-35042 Rennes Cedex (France)

    2013-09-16

    Crystallization and morphological features of syndiotactic-b-atactic polystyrene stereodiblock copolymers (sPS-b-aPS), atactic/syndiotactic polystyrene blends (aPS/sPS), and aPS/sPS blends modified with sPS-b-aPS, with different compositions in aPS and sPS, have been investigated using differential scanning calorimetry (DSC), polarized light optical microscopy (POM) and wide angle X-ray diffraction (WAXRD) techniques. For comparative purposes, the properties of parent pristine sPS samples were also studied. WAXRD analyses revealed for all the samples, independently from their composition (aPS/sPS ratio) and structure (blends, block copolymers, blends modified with block copolymers), the same polymorphic β form of sPS. The molecular weight of aPS and sPS showed opposite effects on the crystallization of 50:50 aPS/sPS blends: the lower the molecular weight of aPS, the slower the crystallization while the lower the molecular weight of sPS, the faster the crystallization. DSC studies performed under both isothermal and non-isothermal conditions, independently confirmed by POM studies, led to a clear trend for the crystallization rate at a given sPS/aPS ratio (ca. 50:50 and 20:80): sPS homopolymers > sPS-b-aPS block copolymers ∼sPS/aPS blends modified with sPS-b-aPS copolymers > sPS/aPS blends. Interestingly, sPS-b-aPS block copolymers not only crystallized faster than blends, but also affected positively the crystallization behavior of blends. At 50:50 sPS/aPS ratio, blends (Blend-2), block copolymers (Cop-1) and blends modified with block copolymers (Blend-2-mod) crystallized via spherulitic crystalline growth controlled by an interfacial process. In all cases, an instantaneous nucleation was observed. The density of nuclei in block copolymers (160,000−190,000 nuclei mm{sup −3}) was always higher than that in blends and modified blends (30,000−60,000 nuclei mm{sup −3}), even for quite different sPS/aPS ratio. At 20:80 sPS/aPS ratio, the block copolymers

  12. Quantitative determination of proteins at nanogram levels by the resonance light-scattering technique with macromolecules nanoparticles of PS?AA

    Science.gov (United States)

    Wang, Leyu; Chen, Hongqi; Li, Ling; Xia, Tingting; Dong, Ling; Wang, Lun

    2004-03-01

    The polystyrene-acrylic acid (PS-AA) nanoparticles have been prepared by ultrasonic polymerization, characterized by FT-IR and TEM. It is the first report on the determination of proteins with macromolecules nanoparticles of PS-AA by resonance light-scattering (RLS). At pH 6.9, the RLS of macromolecules nanoparticles of PS-AA can be enhanced by proteins. Based on this, a novel quantitative assay of proteins at the nanogram levels has been proposed. At pH 6.9, the RLS signals of PS-AA were greatly enhanced by proteins in the region of 250-700 nm characterized by the peak at 342 nm. Under optimal conditions, the linear ranges of the calibration curves were 0.02-11.0 μg ml -1, 0.04-10.0 μg ml -1 and 0.03-10.0 μg ml -1 for γ-globulin (γ-IgG), bovine serum albumin (BSA) and human serum albumin (HSA), respectively. The detection limits were 16.0 ng ml -1, 19.0 ng ml -1, and 15.0 ng ml -1 for γ-IgG, BSA and HSA, respectively. The method has been applied to the analysis of total proteins in human serum samples collected from the hospital and the results were in good agreement with those reported by the hospital, which indicates that the method presented here is not only sensitive, simple, but also reliable and suitable for practical application.

  13. Basics, common errors and essentials of statistical tools and techniques in anesthesiology research.

    Science.gov (United States)

    Bajwa, Sukhminder Jit Singh

    2015-01-01

    The statistical portion is a vital component of any research study. The research methodology and the application of statistical tools and techniques have evolved over the years and have significantly helped the research activities throughout the globe. The results and inferences are not accurately possible without proper validation with various statistical tools and tests. The evidencebased anesthesia research and practice has to incorporate statistical tools in the methodology right from the planning stage of the study itself. Though the medical fraternity is well acquainted with the significance of statistics in research, there is a lack of in-depth knowledge about the various statistical concepts and principles among majority of the researchers. The clinical impact and consequences can be serious as the incorrect analysis, conclusions, and false results may construct an artificial platform on which future research activities are replicated. The present tutorial is an attempt to make anesthesiologists aware of the various aspects of statistical methods used in evidence-based research and also to highlight the common areas where maximum number of statistical errors are committed so as to adopt better statistical practices.

  14. Statistics

    CERN Document Server

    Hayslett, H T

    1991-01-01

    Statistics covers the basic principles of Statistics. The book starts by tackling the importance and the two kinds of statistics; the presentation of sample data; the definition, illustration and explanation of several measures of location; and the measures of variation. The text then discusses elementary probability, the normal distribution and the normal approximation to the binomial. Testing of statistical hypotheses and tests of hypotheses about the theoretical proportion of successes in a binomial population and about the theoretical mean of a normal population are explained. The text the

  15. A STATISTICAL CORRELATION TECHNIQUE AND A NEURAL-NETWORK FOR THE MOTION CORRESPONDENCE PROBLEM

    NARCIS (Netherlands)

    VANDEEMTER, JH; MASTEBROEK, HAK

    A statistical correlation technique (SCT) and two variants of a neural network are presented to solve the motion correspondence problem. Solutions of the motion correspondence problem aim to maintain the identities of individuated elements as they move. In a preprocessing stage, two snapshots of a

  16. Nuclear Technology. Course 26: Metrology. Module 27-7, Statistical Techniques in Metrology.

    Science.gov (United States)

    Espy, John; Selleck, Ben

    This seventh in a series of eight modules for a course titled Metrology focuses on descriptive and inferential statistical techniques in metrology. The module follows a typical format that includes the following sections: (1) introduction, (2) module prerequisites, (3) objectives, (4) notes to instructor/student, (5) subject matter, (6) materials…

  17. Statistical Techniques Used in Published Articles: A Historical Review of Reviews

    Science.gov (United States)

    Skidmore, Susan Troncoso; Thompson, Bruce

    2010-01-01

    The purpose of the present study is to provide a historical account and metasynthesis of which statistical techniques are most frequently used in the fields of education and psychology. Six articles reviewing the "American Educational Research Journal" from 1969 to 1997 and five articles reviewing the psychological literature from 1948 to 2001…

  18. Statistical designs and response surface techniques for the optimization of chromatographic systems.

    Science.gov (United States)

    Ferreira, Sergio Luis Costa; Bruns, Roy Edward; da Silva, Erik Galvão Paranhos; Dos Santos, Walter Nei Lopes; Quintella, Cristina Maria; David, Jorge Mauricio; de Andrade, Jailson Bittencourt; Breitkreitz, Marcia Cristina; Jardim, Isabel Cristina Sales Fontes; Neto, Benicio Barros

    2007-07-27

    This paper describes fundamentals and applications of multivariate statistical techniques for the optimization of chromatographic systems. The surface response methodologies: central composite design, Doehlert matrix and Box-Behnken design are discussed and applications of these techniques for optimization of sample preparation steps (extractions) and determination of experimental conditions for chromatographic separations are presented. The use of mixture design for optimization of mobile phases is also related. An optimization example involving a real separation process is exhaustively described. A discussion about model validation is presented. Some applications of other multivariate techniques for optimization of chromatographic methods are also summarized.

  19. The application of statistical and/or non-statistical sampling techniques by internal audit functions in the South African banking industry

    Directory of Open Access Journals (Sweden)

    D.P. van der Nest

    2015-03-01

    Full Text Available This article explores the use by internal audit functions of audit sampling techniques in order to test the effectiveness of controls in the banking sector. The article focuses specifically on the use of statistical and/or non-statistical sampling techniques by internal auditors. The focus of the research for this article was internal audit functions in the banking sector of South Africa. The results discussed in the article indicate that audit sampling is still used frequently as an audit evidence-gathering technique. Non-statistical sampling techniques are used more frequently than statistical sampling techniques for the evaluation of the sample. In addition, both techniques are regarded as important for the determination of the sample size and the selection of the sample items

  20. Application of Multivariable Statistical Techniques in Plant-wide WWTP Control Strategies Analysis

    DEFF Research Database (Denmark)

    Flores Alsina, Xavier; Comas, J.; Rodríguez-Roda, I.

    2007-01-01

    The main objective of this paper is to present the application of selected multivariable statistical techniques in plant-wide wastewater treatment plant (WWTP) control strategies analysis. In this study, cluster analysis (CA), principal component analysis/factor analysis (PCA/FA) and discriminant...... analysis (DA) are applied to the evaluation matrix data set obtained by simulation of several control strategies applied to the plant-wide IWA Benchmark Simulation Model No 2 (BSM2). These techniques allow i) to determine natural groups or clusters of control strategies with a similar behaviour, ii......) to find and interpret hidden, complex and casual relation features in the data set and iii) to identify important discriminant variables within the groups found by the cluster analysis. This study illustrates the usefulness of multivariable statistical techniques for both analysis and interpretation...

  1. Statistics

    Science.gov (United States)

    Links to sources of cancer-related statistics, including the Surveillance, Epidemiology and End Results (SEER) Program, SEER-Medicare datasets, cancer survivor prevalence data, and the Cancer Trends Progress Report.

  2. Last PS magnet refurbished

    CERN Document Server

    2009-01-01

    PS Magnet Refurbishment Programme Completed. The 51st and final refurbished magnet was transported to the PS on Tuesday 3 February. The repair and consolidation work on the PS started back in 2003 when two magnets and a busbar connection were found to be faulty during routine high-voltage tests. The cause of the fault was a combination of age and radiation on electrical insulation. After further investigation the decision was taken to overhaul half of the PS’s 100 magnets to reduce the risk of a similar fault. As from 20 February the PS ring will start a five-week test programme to be ready for operation at the end of March.

  3. An estimate of future climate change for western France using a statistical downscaling technique

    Energy Technology Data Exchange (ETDEWEB)

    Timbal, B.; Dufour, A.; McAvaney, B. [Bureau of Meteorology Research Centre, GPO Box 1289k, Melbourne, VIC 3001 (Australia)

    2003-05-01

    Heading Abstract A statistical downscaling procedure based on an analogue technique is used to determine projections for future climate change in western France. Three ocean and atmosphere coupled models are used as the starting point of the regionalization technique. Models' climatology and day to day variability are found to reproduce the broad main characteristics seen in the reanalyses. The response of the coupled models to a similar CO{sub 2} increase scenario exhibit marked differences for mean sea-level pressure; precipitable water and temperature show arguably less spread. Using the reanalysis fields as predictors, the statistical model parameters are set for daily extreme temperatures and rain occurrences for seventeen stations in western France. The technique shows some amount of skill for all three predictands and across all seasons but failed to give reliable estimates of rainfall amounts. The quality of both local observations and large-scale predictors has an impact on the statistical model skill. The technique is partially able to reproduce the observed climatic trends and inter annual variability, showing the sensitivity of the analogue approach to changed climatic conditions albeit an incomplete explained variance by the statistical technique. The model is applied to the coupled model control simulations and the gain compared with direct model grid-average outputs is shown to be substantial at station level. The method is then applied to altered climate conditions; the impact of large-scale model uncertain responses and model sensitivities are quantified using the three coupled models. The warming in the downscaled projections are reduced compared with their global model counterparts. (orig.)

  4. Comparison of adaptive statistical iterative and filtered back projection reconstruction techniques in brain CT

    Energy Technology Data Exchange (ETDEWEB)

    Ren, Qingguo, E-mail: renqg83@163.com [Department of Radiology, Hua Dong Hospital of Fudan University, Shanghai 200040 (China); Dewan, Sheilesh Kumar, E-mail: sheilesh_d1@hotmail.com [Department of Geriatrics, Hua Dong Hospital of Fudan University, Shanghai 200040 (China); Li, Ming, E-mail: minli77@163.com [Department of Radiology, Hua Dong Hospital of Fudan University, Shanghai 200040 (China); Li, Jianying, E-mail: Jianying.Li@med.ge.com [CT Imaging Research Center, GE Healthcare China, Beijing (China); Mao, Dingbiao, E-mail: maodingbiao74@163.com [Department of Radiology, Hua Dong Hospital of Fudan University, Shanghai 200040 (China); Wang, Zhenglei, E-mail: Williswang_doc@yahoo.com.cn [Department of Radiology, Shanghai Electricity Hospital, Shanghai 200050 (China); Hua, Yanqing, E-mail: cjr.huayanqing@vip.163.com [Department of Radiology, Hua Dong Hospital of Fudan University, Shanghai 200040 (China)

    2012-10-15

    Purpose: To compare image quality and visualization of normal structures and lesions in brain computed tomography (CT) with adaptive statistical iterative reconstruction (ASIR) and filtered back projection (FBP) reconstruction techniques in different X-ray tube current–time products. Materials and methods: In this IRB-approved prospective study, forty patients (nineteen men, twenty-one women; mean age 69.5 ± 11.2 years) received brain scan at different tube current–time products (300 and 200 mAs) in 64-section multi-detector CT (GE, Discovery CT750 HD). Images were reconstructed with FBP and four levels of ASIR-FBP blending. Two radiologists (please note that our hospital is renowned for its geriatric medicine department, and these two radiologists are more experienced in chronic cerebral vascular disease than in neoplastic disease, so this research did not contain cerebral tumors but as a discussion) assessed all the reconstructed images for visibility of normal structures, lesion conspicuity, image contrast and diagnostic confidence in a blinded and randomized manner. Volume CT dose index (CTDI{sub vol}) and dose-length product (DLP) were recorded. All the data were analyzed by using SPSS 13.0 statistical analysis software. Results: There was no statistically significant difference between the image qualities at 200 mAs with 50% ASIR blending technique and 300 mAs with FBP technique (p > .05). While between the image qualities at 200 mAs with FBP and 300 mAs with FBP technique a statistically significant difference (p < .05) was found. Conclusion: ASIR provided same image quality and diagnostic ability in brain imaging with greater than 30% dose reduction compared with FBP reconstruction technique.

  5. Hierarchical probabilistic regionalization of volcanism for Sengan region in Japan using multivariate statistical techniques and geostatistical interpolation techniques

    Energy Technology Data Exchange (ETDEWEB)

    Park, Jinyong [Univ. of Arizona, Tucson, AZ (United States); Balasingham, P [Univ. of Arizona, Tucson, AZ (United States); McKenna, Sean Andrew [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Kulatilake, Pinnaduwa H.S.W. [Univ. of Arizona, Tucson, AZ (United States)

    2004-09-01

    Sandia National Laboratories, under contract to Nuclear Waste Management Organization of Japan (NUMO), is performing research on regional classification of given sites in Japan with respect to potential volcanic disruption using multivariate statistics and geo-statistical interpolation techniques. This report provides results obtained for hierarchical probabilistic regionalization of volcanism for the Sengan region in Japan by applying multivariate statistical techniques and geostatistical interpolation techniques on the geologic data provided by NUMO. A workshop report produced in September 2003 by Sandia National Laboratories (Arnold et al., 2003) on volcanism lists a set of most important geologic variables as well as some secondary information related to volcanism. Geologic data extracted for the Sengan region in Japan from the data provided by NUMO revealed that data are not available at the same locations for all the important geologic variables. In other words, the geologic variable vectors were found to be incomplete spatially. However, it is necessary to have complete geologic variable vectors to perform multivariate statistical analyses. As a first step towards constructing complete geologic variable vectors, the Universal Transverse Mercator (UTM) zone 54 projected coordinate system and a 1 km square regular grid system were selected. The data available for each geologic variable on a geographic coordinate system were transferred to the aforementioned grid system. Also the recorded data on volcanic activity for Sengan region were produced on the same grid system. Each geologic variable map was compared with the recorded volcanic activity map to determine the geologic variables that are most important for volcanism. In the regionalized classification procedure, this step is known as the variable selection step. The following variables were determined as most important for volcanism: geothermal gradient, groundwater temperature, heat discharge, groundwater

  6. Evaluation of spatial and temporal variations in marine sediments quality using multivariate statistical techniques.

    Science.gov (United States)

    Alvarez, Odalys Quevedo; Tagle, Margarita Edelia Villanueva; Pascual, Jorge L Gómez; Marín, Ma Teresa Larrea; Clemente, Ana Catalina Nuñez; Medina, Miriam Odette Cora; Palau, Raiza Rey; Alfonso, Mario Simeón Pomares

    2014-10-01

    Spatial and temporal variations of sediment quality in Matanzas Bay (Cuba) were studied by determining a total of 12 variables (Zn, Cu, Pb, As, Ni, Co, Al, Fe, Mn, V, CO₃²⁻, and total hydrocarbons (THC). Surface sediments were collected, annually, at eight stations during 2005-2008. Multivariate statistical techniques, such as principal component (PCA), cluster (CA), and lineal discriminant (LDA) analyses were applied for identification of the most significant variables influencing the environmental quality of sediments. Heavy metals (Zn, Cu, Pb, V, and As) and THC were the most significant species contributing to sediment quality variations during the sampling period. Concentrations of V and As were determined in sediments of this ecosystem for the first time. The variation of sediment environmental quality with the sampling period and the differentiation of samples in three groups along the bay were obtained. The usefulness of the multivariate statistical techniques employed for the environmental interpretation of a limited dataset was confirmed.

  7. An Automated Energy Detection Algorithm Based on Morphological and Statistical Processing Techniques

    Science.gov (United States)

    2018-01-09

    ARL-TR-8272 ● JAN 2018 US Army Research Laboratory An Automated Energy Detection Algorithm Based on Morphological and...is no longer needed. Do not return it to the originator. ARL-TR-8272 ● JAN 2018 US Army Research Laboratory An Automated Energy ...4. TITLE AND SUBTITLE An Automated Energy Detection Algorithm Based on Morphological and Statistical Processing Techniques 5a. CONTRACT NUMBER

  8. The statistical analysis techniques to support the NGNP fuel performance experiments

    Science.gov (United States)

    Pham, Binh T.; Einerson, Jeffrey J.

    2013-10-01

    This paper describes the development and application of statistical analysis techniques to support the Advanced Gas Reactor (AGR) experimental program on Next Generation Nuclear Plant (NGNP) fuel performance. The experiments conducted in the Idaho National Laboratory's Advanced Test Reactor employ fuel compacts placed in a graphite cylinder shrouded by a steel capsule. The tests are instrumented with thermocouples embedded in graphite blocks and the target quantity (fuel temperature) is regulated by the He-Ne gas mixture that fills the gap volume. Three techniques for statistical analysis, namely control charting, correlation analysis, and regression analysis, are implemented in the NGNP Data Management and Analysis System for automated processing and qualification of the AGR measured data. The neutronic and thermal code simulation results are used for comparative scrutiny. The ultimate objective of this work includes (a) a multi-faceted system for data monitoring and data accuracy testing, (b) identification of possible modes of diagnostics deterioration and changes in experimental conditions, (c) qualification of data for use in code validation, and (d) identification and use of data trends to support effective control of test conditions with respect to the test target. Analysis results and examples given in the paper show the three statistical analysis techniques providing a complementary capability to warn of thermocouple failures. It also suggests that the regression analysis models relating calculated fuel temperatures and thermocouple readings can enable online regulation of experimental parameters (i.e. gas mixture content), to effectively maintain the fuel temperature within a given range.

  9. Statistical and Machine-Learning Data Mining Techniques for Better Predictive Modeling and Analysis of Big Data

    CERN Document Server

    Ratner, Bruce

    2011-01-01

    The second edition of a bestseller, Statistical and Machine-Learning Data Mining: Techniques for Better Predictive Modeling and Analysis of Big Data is still the only book, to date, to distinguish between statistical data mining and machine-learning data mining. The first edition, titled Statistical Modeling and Analysis for Database Marketing: Effective Techniques for Mining Big Data, contained 17 chapters of innovative and practical statistical data mining techniques. In this second edition, renamed to reflect the increased coverage of machine-learning data mining techniques, the author has

  10. Detection of abnormal fermentations in wine process by multivariate statistics and pattern recognition techniques.

    Science.gov (United States)

    Urtubia, A; Hernández, G; Roger, J M

    2012-06-30

    Three multivariate statistical techniques (Multiway Principal Component Analysis, Multiway Partial Least Squares, and Stepwise Linear Discriminant Analysis) and one artificial intelligence method (Artificial Neural Networks) were evaluated to detect and predict early abnormal behaviors of wine fermentations. The techniques were tested with data of thirty-two variables at different stages of fermentation from industrial wine fermentations of Cabernet Sauvignon. All the techniques studied considered a pre-treatment to obtain a homogeneous space and reduce the overfitting. The results were encouraging; it was possible to classify at 72h 100% of the fermentation correctly with three variables using Multiway Partial Least Squares and Artificial Neural Networks. Additional and complementary results were obtained with Stepwise Linear Discriminant Analysis, which found that ethanol, sugars and density measurements are able to discriminate abnormal behavior. Copyright © 2011 Elsevier B.V. All rights reserved.

  11. ISOLATED SPEECH RECOGNITION SYSTEM FOR TAMIL LANGUAGE USING STATISTICAL PATTERN MATCHING AND MACHINE LEARNING TECHNIQUES

    Directory of Open Access Journals (Sweden)

    VIMALA C.

    2015-05-01

    Full Text Available In recent years, speech technology has become a vital part of our daily lives. Various techniques have been proposed for developing Automatic Speech Recognition (ASR system and have achieved great success in many applications. Among them, Template Matching techniques like Dynamic Time Warping (DTW, Statistical Pattern Matching techniques such as Hidden Markov Model (HMM and Gaussian Mixture Models (GMM, Machine Learning techniques such as Neural Networks (NN, Support Vector Machine (SVM, and Decision Trees (DT are most popular. The main objective of this paper is to design and develop a speaker-independent isolated speech recognition system for Tamil language using the above speech recognition techniques. The background of ASR system, the steps involved in ASR, merits and demerits of the conventional and machine learning algorithms and the observations made based on the experiments are presented in this paper. For the above developed system, highest word recognition accuracy is achieved with HMM technique. It offered 100% accuracy during training process and 97.92% for testing process.

  12. Selecting statistical or machine learning techniques for regional landslide susceptibility modelling by evaluating spatial prediction

    Science.gov (United States)

    Goetz, Jason; Brenning, Alexander; Petschko, Helene; Leopold, Philip

    2015-04-01

    With so many techniques now available for landslide susceptibility modelling, it can be challenging to decide on which technique to apply. Generally speaking, the criteria for model selection should be tied closely to end users' purpose, which could be spatial prediction, spatial analysis or both. In our research, we focus on comparing the spatial predictive abilities of landslide susceptibility models. We illustrate how spatial cross-validation, a statistical approach for assessing spatial prediction performance, can be applied with the area under the receiver operating characteristic curve (AUROC) as a prediction measure for model comparison. Several machine learning and statistical techniques are evaluated for prediction in Lower Austria: support vector machine, random forest, bundling with penalized linear discriminant analysis, logistic regression, weights of evidence, and the generalized additive model. In addition to predictive performance, the importance of predictor variables in each model was estimated using spatial cross-validation by calculating the change in AUROC performance when variables are randomly permuted. The susceptibility modelling techniques were tested in three areas of interest in Lower Austria, which have unique geologic conditions associated with landslide occurrence. Overall, we found for the majority of comparisons that there were little practical or even statistically significant differences in AUROCs. That is the models' prediction performances were very similar. Therefore, in addition to prediction, the ability to interpret models for spatial analysis and the qualitative qualities of the prediction surface (map) are considered and discussed. The measure of variable importance provided some insight into the model behaviour for prediction, in particular for "black-box" models. However, there were no clear patterns in all areas of interest to why certain variables were given more importance over others.

  13. Assessment technique for acne treatments based on statistical parameters of skin thermal images.

    Science.gov (United States)

    Padilla-Medina, J Alfredo; León-Ordoñez, Francisco; Prado-Olivarez, Juan; Vela-Aguirre, Noe; Ramírez-Agundis, Agustin; Díaz-Carmona, Javier

    2014-04-01

    Acne vulgaris as an inflammatory disease, with an excessive production of subdermal fat, modifies the dynamics of the bloodstream, and consequently temperature, on the affected skin zone. A high percentage of this heat interchange is manifested as electromagnetic radiation with far-infrared wavelengths, which can be captured through a thermal imaging camera. A technique based on thermal image analysis for efficiency assessment in acne vulgaris is described. The procedure is based on computing statistical parameters of thermal images captured from the affected skin zone being attended by an acne treatment. The proposed technique was used to determine the skin thermal behavior according to acne severity levels in different acne treatment stages. Infrared images of acne skin zones on eight patients, diagnosed with acne vulgaris and attended by one specific acne treatment, were weekly registered during 11 weeks. The infrared images were captured until no more improvement in affected zones was detected. The obtained results suggest a direct relationship between the used statistical parameters, particularly first- and second-order statistics, and the acne vulgaris severity level on the affected zones.

  14. Application of statistical downscaling technique for the production of wine grapes (Vitis vinifera L.) in Spain

    Science.gov (United States)

    Gaitán Fernández, E.; García Moreno, R.; Pino Otín, M. R.; Ribalaygua Batalla, J.

    2012-04-01

    Climate and soil are two of the most important limiting factors for agricultural production. Nowadays climate change has been documented in many geographical locations affecting different cropping systems. The General Circulation Models (GCM) has become important tools to simulate the more relevant aspects of the climate expected for the XXI century in the frame of climatic change. These models are able to reproduce the general features of the atmospheric dynamic but their low resolution (about 200 Km) avoids a proper simulation of lower scale meteorological effects. Downscaling techniques allow overcoming this problem by adapting the model outcomes to local scale. In this context, FIC (Fundación para la Investigación del Clima) has developed a statistical downscaling technique based on a two step analogue methods. This methodology has been broadly tested on national and international environments leading to excellent results on future climate models. In a collaboration project, this statistical downscaling technique was applied to predict future scenarios for the grape growing systems in Spain. The application of such model is very important to predict expected climate for the different growing crops, mainly for grape, where the success of different varieties are highly related to climate and soil. The model allowed the implementation of agricultural conservation practices in the crop production, detecting highly sensible areas to negative impacts produced by any modification of climate in the different regions, mainly those protected with protected designation of origin, and the definition of new production areas with optimal edaphoclimatic conditions for the different varieties.

  15. A Review of Statistical Disclosure Control Techniques Employed by Web-Based Data Query Systems.

    Science.gov (United States)

    Matthews, Gregory J; Harel, Ofer; Aseltine, Robert H

    We systematically reviewed the statistical disclosure control techniques employed for releasing aggregate data in Web-based data query systems listed in the National Association for Public Health Statistics and Information Systems (NAPHSIS). Each Web-based data query system was examined to see whether (1) it employed any type of cell suppression, (2) it used secondary cell suppression, and (3) suppressed cell counts could be calculated. No more than 30 minutes was spent on each system. Of the 35 systems reviewed, no suppression was observed in more than half (n = 18); observed counts below the threshold were observed in 2 sites; and suppressed values were recoverable in 9 sites. Six sites effectively suppressed small counts. This inquiry has revealed substantial weaknesses in the protective measures used in data query systems containing sensitive public health data. Many systems utilized no disclosure control whatsoever, and the vast majority of those that did deployed it inconsistently or inadequately.

  16. Inside the PS tunnel

    CERN Multimedia

    1974-01-01

    Pre-start work is going on at the end of the PS long shut-down. The photo shows secondary beams drawn from an internal target (bottom) towards South Hall, behind the shielding wall (top) (see also photo 7409012X).

  17. PS Control Room

    CERN Multimedia

    CERN PhotoLab

    1963-01-01

    The good old PS Control Room, all manual. For each parameter, a knob or a button to control it; for each, a light or meter or oscilloscope to monitor it; carefully written pages serve as the data bank; phones and intercom for communication. D.Dekkers is at the microphone, M.Valvini sits in front.

  18. PS auxiliary magnet

    CERN Multimedia

    CERN PhotoLab

    1974-01-01

    Units of the PS auxiliary magnet system. The picture shows how the new dipoles, used for vertical and horizontal high-energy beam manipulation, are split for installation and removal so that it is not necessary to break the accelerator vacuum. On the right, adjacent to the sector valve and the windings of the main magnet, is an octupole of the set.

  19. GIS-based bivariate statistical techniques for groundwater potential analysis (an example of Iran)

    Science.gov (United States)

    Haghizadeh, Ali; Moghaddam, Davoud Davoudi; Pourghasemi, Hamid Reza

    2017-12-01

    Groundwater potential analysis prepares better comprehension of hydrological settings of different regions. This study shows the potency of two GIS-based data driven bivariate techniques namely statistical index (SI) and Dempster-Shafer theory (DST) to analyze groundwater potential in Broujerd region of Iran. The research was done using 11 groundwater conditioning factors and 496 spring positions. Based on the ground water potential maps (GPMs) of SI and DST methods, 24.22% and 23.74% of the study area is covered by poor zone of groundwater potential, and 43.93% and 36.3% of Broujerd region is covered by good and very good potential zones, respectively. The validation of outcomes displayed that area under the curve (AUC) of SI and DST techniques are 81.23% and 79.41%, respectively, which shows SI method has slightly a better performance than the DST technique. Therefore, SI and DST methods are advantageous to analyze groundwater capacity and scrutinize the complicated relation between groundwater occurrence and groundwater conditioning factors, which permits investigation of both systemic and stochastic uncertainty. Finally, it can be realized that these techniques are very beneficial for groundwater potential analyzing and can be practical for water-resource management experts.

  20. Mathematical and Statistical Techniques for Systems Medicine: The Wnt Signaling Pathway as a Case Study

    KAUST Repository

    MacLean, Adam L.

    2015-12-16

    The last decade has seen an explosion in models that describe phenomena in systems medicine. Such models are especially useful for studying signaling pathways, such as the Wnt pathway. In this chapter we use the Wnt pathway to showcase current mathematical and statistical techniques that enable modelers to gain insight into (models of) gene regulation and generate testable predictions. We introduce a range of modeling frameworks, but focus on ordinary differential equation (ODE) models since they remain the most widely used approach in systems biology and medicine and continue to offer great potential. We present methods for the analysis of a single model, comprising applications of standard dynamical systems approaches such as nondimensionalization, steady state, asymptotic and sensitivity analysis, and more recent statistical and algebraic approaches to compare models with data. We present parameter estimation and model comparison techniques, focusing on Bayesian analysis and coplanarity via algebraic geometry. Our intention is that this (non-exhaustive) review may serve as a useful starting point for the analysis of models in systems medicine.

  1. Statistical Techniques Complement UML When Developing Domain Models of Complex Dynamical Biosystems.

    Science.gov (United States)

    Williams, Richard A; Timmis, Jon; Qwarnstrom, Eva E

    2016-01-01

    Computational modelling and simulation is increasingly being used to complement traditional wet-lab techniques when investigating the mechanistic behaviours of complex biological systems. In order to ensure computational models are fit for purpose, it is essential that the abstracted view of biology captured in the computational model, is clearly and unambiguously defined within a conceptual model of the biological domain (a domain model), that acts to accurately represent the biological system and to document the functional requirements for the resultant computational model. We present a domain model of the IL-1 stimulated NF-κB signalling pathway, which unambiguously defines the spatial, temporal and stochastic requirements for our future computational model. Through the development of this model, we observe that, in isolation, UML is not sufficient for the purpose of creating a domain model, and that a number of descriptive and multivariate statistical techniques provide complementary perspectives, in particular when modelling the heterogeneity of dynamics at the single-cell level. We believe this approach of using UML to define the structure and interactions within a complex system, along with statistics to define the stochastic and dynamic nature of complex systems, is crucial for ensuring that conceptual models of complex dynamical biosystems, which are developed using UML, are fit for purpose, and unambiguously define the functional requirements for the resultant computational model.

  2. Evaluating Statistical Process Control (SPC) techniques and computing the uncertainty of force calibrations

    Science.gov (United States)

    Navard, Sharon E.

    1989-01-01

    In recent years there has been a push within NASA to use statistical techniques to improve the quality of production. Two areas where statistics are used are in establishing product and process quality control of flight hardware and in evaluating the uncertainty of calibration of instruments. The Flight Systems Quality Engineering branch is responsible for developing and assuring the quality of all flight hardware; the statistical process control methods employed are reviewed and evaluated. The Measurement Standards and Calibration Laboratory performs the calibration of all instruments used on-site at JSC as well as those used by all off-site contractors. These calibrations must be performed in such a way as to be traceable to national standards maintained by the National Institute of Standards and Technology, and they must meet a four-to-one ratio of the instrument specifications to calibrating standard uncertainty. In some instances this ratio is not met, and in these cases it is desirable to compute the exact uncertainty of the calibration and determine ways of reducing it. A particular example where this problem is encountered is with a machine which does automatic calibrations of force. The process of force calibration using the United Force Machine is described in detail. The sources of error are identified and quantified when possible. Suggestions for improvement are made.

  3. The Novel Quantitative Technique for Assessment of Gait Symmetry Using Advanced Statistical Learning Algorithm

    Directory of Open Access Journals (Sweden)

    Jianning Wu

    2015-01-01

    Full Text Available The accurate identification of gait asymmetry is very beneficial to the assessment of at-risk gait in the clinical applications. This paper investigated the application of classification method based on statistical learning algorithm to quantify gait symmetry based on the assumption that the degree of intrinsic change in dynamical system of gait is associated with the different statistical distributions between gait variables from left-right side of lower limbs; that is, the discrimination of small difference of similarity between lower limbs is considered the reorganization of their different probability distribution. The kinetic gait data of 60 participants were recorded using a strain gauge force platform during normal walking. The classification method is designed based on advanced statistical learning algorithm such as support vector machine algorithm for binary classification and is adopted to quantitatively evaluate gait symmetry. The experiment results showed that the proposed method could capture more intrinsic dynamic information hidden in gait variables and recognize the right-left gait patterns with superior generalization performance. Moreover, our proposed techniques could identify the small significant difference between lower limbs when compared to the traditional symmetry index method for gait. The proposed algorithm would become an effective tool for early identification of the elderly gait asymmetry in the clinical diagnosis.

  4. I, S, T, and J Grading Techniques for Es, Ns, Fs, and Ps: Insights from the MBTI on Managing the Grading Process

    Science.gov (United States)

    Fornaciari, Charles J.; Lund Dean, Kathy

    2013-01-01

    Most instructors at least occasionally experience grading student work as a frustrating, time-consuming task. The Myers-Briggs Type Indicator (MBTI) instrument can be a powerful self-awareness tool for management educators seeking to enhance their grading techniques. Evidence suggests that many management professors prefer Extraversion (E),…

  5. Application of multivariate statistical techniques to evaluate organic pollution on a river in Argentina

    Directory of Open Access Journals (Sweden)

    Patricia S. González

    2011-12-01

    Full Text Available The aim of this paper was the application of multivariate statistical techniques to evaluate spatial and temporal variations in the water quality of Potrero de los Funes River using physical, chemical and bacteriological parameters and select the most significant parameters of organic pollution in the river in order to implement in the future water quality monitoring. The river was monitored regularly at three sites: RP1, RP2 and RP3, over the period 2008–2009, for 16 parameters. The complex data matrix was treated with three multivariate statistical techniques: cluster analysis (CA, principal component analysis (PCA and discriminant analysis (DA. CA generated three groups of sites, cluster 1 (RP1, cluster 2 (RP2 and cluster 3 (RP3 according to relatively low, very high and moderate pollution regions, respectively. PCA identified two components, which were responsible for the data structure explaining 73% of the total variance of the data matrix. Temporal DA (Wet season and Dry season showed that turbidity, NO3- and COD were the discriminant variables. Spatial DA shows that there were significant differences between the three categorical classes, 1 (RP1, low pollution region, 2 (RP2, strongly polluted zone and 3 (RP3, moderate polluted site .The discriminating functions contained only eight parameters (EC, NO3-, turbidity, DO, BOD, COD, total coliform and fecal coliform to discriminate between sites. The application of these techniques has achieved meaningful classification of physical, chemical and bacteriological variables and of river water samples, based on seasonal and spatial criteria. This study is essential for the future design of fast and effective monitoring programs of river water quality. That would include only parameters that are indicative of organic pollution.

  6. A Modified Moore Approach to Teaching Mathematical Statistics: An Inquiry Based Learning Technique to Teaching Mathematical Statistics

    Science.gov (United States)

    McLoughlin, M. Padraig M. M.

    2008-01-01

    The author of this paper submits the thesis that learning requires doing; only through inquiry is learning achieved, and hence this paper proposes a programme of use of a modified Moore method in a Probability and Mathematical Statistics (PAMS) course sequence to teach students PAMS. Furthermore, the author of this paper opines that set theory…

  7. PS injection area

    CERN Multimedia

    1974-01-01

    Looking against the direction of protons in the main ring (left): the beam coming from the linac 1 either goes to the booster (on the right) or is deflected towards the PS to be directly injected into section 26 (facing the camera). Also shown the start of the TT2 line, ejected from straight section 16 to go towards the ISR passing over the beam line from the linac. (see Photo Archive 7409009)

  8. PS injection area

    CERN Multimedia

    1974-01-01

    To the right is the PS ring viewed along the direction of the protons. At the left the injection line coming from the 50 MeV Linac 1 (bottom) and going towards the 800 MeV booster, or deflected to the right to be injected directly into straight section 16. The drumlike element behind the (blue) dipole magnet is a 'debuncher' (a 200 MHz cavity). See photos 7409014X and 7409009.

  9. Performance evaluation of a hybrid-passive landfill leachate treatment system using multivariate statistical techniques

    Energy Technology Data Exchange (ETDEWEB)

    Wallace, Jack, E-mail: jack.wallace@ce.queensu.ca [Department of Civil Engineering, Queen’s University, Ellis Hall, 58 University Avenue, Kingston, Ontario K7L 3N6 (Canada); Champagne, Pascale, E-mail: champagne@civil.queensu.ca [Department of Civil Engineering, Queen’s University, Ellis Hall, 58 University Avenue, Kingston, Ontario K7L 3N6 (Canada); Monnier, Anne-Charlotte, E-mail: anne-charlotte.monnier@insa-lyon.fr [National Institute for Applied Sciences – Lyon, 20 Avenue Albert Einstein, 69621 Villeurbanne Cedex (France)

    2015-01-15

    Highlights: • Performance of a hybrid passive landfill leachate treatment system was evaluated. • 33 Water chemistry parameters were sampled for 21 months and statistically analyzed. • Parameters were strongly linked and explained most (>40%) of the variation in data. • Alkalinity, ammonia, COD, heavy metals, and iron were criteria for performance. • Eight other parameters were key in modeling system dynamics and criteria. - Abstract: A pilot-scale hybrid-passive treatment system operated at the Merrick Landfill in North Bay, Ontario, Canada, treats municipal landfill leachate and provides for subsequent natural attenuation. Collected leachate is directed to a hybrid-passive treatment system, followed by controlled release to a natural attenuation zone before entering the nearby Little Sturgeon River. The study presents a comprehensive evaluation of the performance of the system using multivariate statistical techniques to determine the interactions between parameters, major pollutants in the leachate, and the biological and chemical processes occurring in the system. Five parameters (ammonia, alkalinity, chemical oxygen demand (COD), “heavy” metals of interest, with atomic weights above calcium, and iron) were set as criteria for the evaluation of system performance based on their toxicity to aquatic ecosystems and importance in treatment with respect to discharge regulations. System data for a full range of water quality parameters over a 21-month period were analyzed using principal components analysis (PCA), as well as principal components (PC) and partial least squares (PLS) regressions. PCA indicated a high degree of association for most parameters with the first PC, which explained a high percentage (>40%) of the variation in the data, suggesting strong statistical relationships among most of the parameters in the system. Regression analyses identified 8 parameters (set as independent variables) that were most frequently retained for modeling

  10. Evaluating machine learning and statistical prediction techniques for landslide susceptibility modeling

    Science.gov (United States)

    Goetz, J. N.; Brenning, A.; Petschko, H.; Leopold, P.

    2015-08-01

    Statistical and now machine learning prediction methods have been gaining popularity in the field of landslide susceptibility modeling. Particularly, these data driven approaches show promise when tackling the challenge of mapping landslide prone areas for large regions, which may not have sufficient geotechnical data to conduct physically-based methods. Currently, there is no best method for empirical susceptibility modeling. Therefore, this study presents a comparison of traditional statistical and novel machine learning models applied for regional scale landslide susceptibility modeling. These methods were evaluated by spatial k-fold cross-validation estimation of the predictive performance, assessment of variable importance for gaining insights into model behavior and by the appearance of the prediction (i.e. susceptibility) map. The modeling techniques applied were logistic regression (GLM), generalized additive models (GAM), weights of evidence (WOE), the support vector machine (SVM), random forest classification (RF), and bootstrap aggregated classification trees (bundling) with penalized discriminant analysis (BPLDA). These modeling methods were tested for three areas in the province of Lower Austria, Austria. The areas are characterized by different geological and morphological settings. Random forest and bundling classification techniques had the overall best predictive performances. However, the performances of all modeling techniques were for the majority not significantly different from each other; depending on the areas of interest, the overall median estimated area under the receiver operating characteristic curve (AUROC) differences ranged from 2.9 to 8.9 percentage points. The overall median estimated true positive rate (TPR) measured at a 10% false positive rate (FPR) differences ranged from 11 to 15pp. The relative importance of each predictor was generally different between the modeling methods. However, slope angle, surface roughness and plan

  11. Application of multivariate statistical techniques in the water quality assessment of Danube river, Serbia

    Directory of Open Access Journals (Sweden)

    Voza Danijela

    2015-12-01

    Full Text Available The aim of this article is to evaluate the quality of the Danube River in its course through Serbia as well as to demonstrate the possibilities for using three statistical methods: Principal Component Analysis (PCA, Factor Analysis (FA and Cluster Analysis (CA in the surface water quality management. Given that the Danube is an important trans-boundary river, thorough water quality monitoring by sampling at different distances during shorter and longer periods of time is not only ecological, but also a political issue. Monitoring was carried out at monthly intervals from January to December 2011, at 17 sampling sites. The obtained data set was treated by multivariate techniques in order, firstly, to identify the similarities and differences between sampling periods and locations, secondly, to recognize variables that affect the temporal and spatial water quality changes and thirdly, to present the anthropogenic impact on water quality parameters.

  12. Determining the parameters of high amplification microlensing events by means of statistical machine learning techniques

    Science.gov (United States)

    Fedorova, Elena

    2017-06-01

    Strong gravitational microlensing (GM) events provide us a possibility to determine both the parameters of microlensed source and microlens. GM can be an important clue to understand the nature of dark matter on comparably small spatial and mass scales (i.e. substructure), especially when speaking about the combination of astrometrical and photometrical data about high amplification microlensing events (HAME). In the same time, fitting of HAME lightcurves of microlensed sources is quite time-consuming process. That is why we test here the possibility to apply the statistical machine learning techniques to determine the source and microlens parameters for the set of HAME lightcurves, using the simulated set of amplification curves of sources microlensed by point masses and clumps of DM with various density profiles.

  13. Simple statistical bias correction techniques greatly improve moderate resolution air quality forecast at station level

    Science.gov (United States)

    Curci, Gabriele; Falasca, Serena

    2017-04-01

    Deterministic air quality forecast is routinely carried out at many local Environmental Agencies in Europe and throughout the world by means of eulerian chemistry-transport models. The skill of these models in predicting the ground-level concentrations of relevant pollutants (ozone, nitrogen dioxide, particulate matter) a few days ahead has greatly improved in recent years, but it is not yet always compliant with the required quality level for decision making (e.g. the European Commission has set a maximum uncertainty of 50% on daily values of relevant pollutants). Post-processing of deterministic model output is thus still regarded as a useful tool to make the forecast more reliable. In this work, we test several bias correction techniques applied to a long-term dataset of air quality forecasts over Europe and Italy. We used the WRF-CHIMERE modelling system, which provides operational experimental chemical weather forecast at CETEMPS (http://pumpkin.aquila.infn.it/forechem/), to simulate the years 2008-2012 at low resolution over Europe (0.5° x 0.5°) and moderate resolution over Italy (0.15° x 0.15°). We compared the simulated dataset with available observation from the European Environmental Agency database (AirBase) and characterized model skill and compliance with EU legislation using the Delta tool from FAIRMODE project (http://fairmode.jrc.ec.europa.eu/). The bias correction techniques adopted are, in order of complexity: (1) application of multiplicative factors calculated as the ratio of model-to-observed concentrations averaged over the previous days; (2) correction of the statistical distribution of model forecasts, in order to make it similar to that of the observations; (3) development and application of Model Output Statistics (MOS) regression equations. We illustrate differences and advantages/disadvantages of the three approaches. All the methods are relatively easy to implement for other modelling systems.

  14. Comparison of adaptive statistical iterative and filtered back projection reconstruction techniques in quantifying coronary calcium.

    Science.gov (United States)

    Takahashi, Masahiro; Kimura, Fumiko; Umezawa, Tatsuya; Watanabe, Yusuke; Ogawa, Harumi

    2016-01-01

    Adaptive statistical iterative reconstruction (ASIR) has been used to reduce radiation dose in cardiac computed tomography. However, change of image parameters by ASIR as compared to filtered back projection (FBP) may influence quantification of coronary calcium. To investigate the influence of ASIR on calcium quantification in comparison to FBP. In 352 patients, CT images were reconstructed using FBP alone, FBP combined with ASIR 30%, 50%, 70%, and ASIR 100% based on the same raw data. Image noise, plaque density, Agatston scores and calcium volumes were compared among the techniques. Image noise, Agatston score, and calcium volume decreased significantly with ASIR compared to FBP (each P ASIR reduced Agatston score by 10.5% to 31.0%. In calcified plaques both of patients and a phantom, ASIR decreased maximum CT values and calcified plaque size. In comparison to FBP, adaptive statistical iterative reconstruction (ASIR) may significantly decrease Agatston scores and calcium volumes. Copyright © 2016 Society of Cardiovascular Computed Tomography. Published by Elsevier Inc. All rights reserved.

  15. Design of U-Geometry Parameters Using Statistical Analysis Techniques in the U-Bending Process

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    Wiriyakorn Phanitwong

    2017-06-01

    Full Text Available The various U-geometry parameters in the U-bending process result in processing difficulties in the control of the spring-back characteristic. In this study, the effects of U-geometry parameters, including channel width, bend angle, material thickness, tool radius, as well as workpiece length, and their design, were investigated using a combination of finite element method (FEM simulation, and statistical analysis techniques. Based on stress distribution analyses, the FEM simulation results clearly identified the different bending mechanisms and effects of U-geometry parameters on the spring-back characteristic in the U-bending process, with and without pressure pads. The statistical analyses elucidated that the bend angle and channel width have a major influence in cases with and without pressure pads, respectively. The experiments were carried out to validate the FEM simulation results. Additionally, the FEM simulation results were in agreement with the experimental results, in terms of the bending forces and bending angles.

  16. New Statistical Techniques in the Measurement of the inclusive Top Pair Production Cross Section

    CERN Document Server

    Franc, Jiří; Štěpánek, Michal; Kůs, Václav

    2014-01-01

    We present several different types of multivariate statistical techniques used in the measurement of the inclusive top pair production cross section in $p \\bar{p}$-collisions at $\\sqrt{s} = 1.96 \\text{TeV}$ employing the full RunII data ($9.7\\textrm{fb}^{-1}$) collected with the D0 detector at the Fermilab Tevatron Collider. We consider the final state of the top quark pair decays containing one electron or muon and at least two jets. We proceed various statistical homogeneity tests such as Anderson - Darling, Kolmogorov - Smirnov, and $\\varphi$-divergences tests to determine, which variables have good data-MC agreement, as well as a good separation power. We adjusted all tests for using weighted empirical distribution functions. Further we separate $t\\bar{t}$ signal from the background by the application of Generalized Linear Models, Gaussian Mixture Models), Neural Networks with Switching Units and confront them with familiar methods from ROOT TMVA package such as Boosted Decision Trees, and Multi-layer Per...

  17. Systematic and Statistical Errors Associated with Nuclear Decay Constant Measurements Using the Counting Technique

    Science.gov (United States)

    Koltick, David; Wang, Haoyu; Liu, Shih-Chieh; Heim, Jordan; Nistor, Jonathan

    2016-03-01

    Typical nuclear decay constants are measured at the accuracy level of 10-2. There are numerous reasons: tests of unconventional theories, dating of materials, and long term inventory evolution which require decay constants accuracy at a level of 10-4 to 10-5. The statistical and systematic errors associated with precision measurements of decays using the counting technique are presented. Precision requires high count rates, which introduces time dependent dead time and pile-up corrections. An approach to overcome these issues is presented by continuous recording of the detector current. Other systematic corrections include, the time dependent dead time due to background radiation, control of target motion and radiation flight path variation due to environmental conditions, and the time dependent effects caused by scattered events are presented. The incorporation of blind experimental techniques can help make measurement independent of past results. A spectrometer design and data analysis is reviewed that can accomplish these goals. The author would like to thank TechSource, Inc. and Advanced Physics Technologies, LLC. for their support in this work.

  18. Remote sensing and spatial statistical techniques for modelling Ommatissus lybicus (Hemiptera: Tropiduchidae) habitat and population densities.

    Science.gov (United States)

    Al-Kindi, Khalifa M; Kwan, Paul; R Andrew, Nigel; Welch, Mitchell

    2017-01-01

    In order to understand the distribution and prevalence of Ommatissus lybicus (Hemiptera: Tropiduchidae) as well as analyse their current biographical patterns and predict their future spread, comprehensive and detailed information on the environmental, climatic, and agricultural practices are essential. The spatial analytical techniques such as Remote Sensing and Spatial Statistics Tools, can help detect and model spatial links and correlations between the presence, absence and density of O. lybicus in response to climatic, environmental, and human factors. The main objective of this paper is to review remote sensing and relevant analytical techniques that can be applied in mapping and modelling the habitat and population density of O. lybicus. An exhaustive search of related literature revealed that there are very limited studies linking location-based infestation levels of pests like the O. lybicus with climatic, environmental, and human practice related variables. This review also highlights the accumulated knowledge and addresses the gaps in this area of research. Furthermore, it makes recommendations for future studies, and gives suggestions on monitoring and surveillance methods in designing both local and regional level integrated pest management strategies of palm tree and other affected cultivated crops.

  19. At PS170 (APPLE)

    CERN Multimedia

    CERN PhotoLab

    1983-01-01

    APPLE stands for Antiproton-Proton to Pair of LEptons (an acronym of the ancestor experiment PAPLEP), the PS170 experiment setup at LEAR to study e+e-pair production in antiproton-proton annihilation by Padova-(CEN) Saclay- Torino Collaboration. It consisted of a liquid hydrogen target surrounded by several layers of proportional chambers in the vertical field of a C-magnet (this photo), a gas Cerenkov counter, wire chambers, hodoscopes, and an electromagnetic calorimeter (see photo 8302539X, 8302540X). See also photo 8301539X for the setup assembly at an early stage.

  20. Propensity Score Techniques and the Assessment of Measured Covariate Balance to Test Causal Associations in Psychological Research

    Science.gov (United States)

    Harder, Valerie S.; Stuart, Elizabeth A.; Anthony, James C.

    2010-01-01

    There is considerable interest in using propensity score (PS) statistical techniques to address questions of causal inference in psychological research. Many PS techniques exist, yet few guidelines are available to aid applied researchers in their understanding, use, and evaluation. In this study, the authors give an overview of available…

  1. Beyond iPS!

    Directory of Open Access Journals (Sweden)

    Editorial

    2012-01-01

    Full Text Available It’s undoubtedly a jubilant moment for scientists and clinicians working in the stem cell arena as Prof. Gurdon and Prof. Shinya Yamanaka have been chosen for the Nobel Prize in Physiology & Medicine this year. The mystery of cell biology is something unfathomable and probably the work of this duo as well as the other scientists, who have put their hands on in- vitro de-differentiation have opened our eyes to a new window or a new paradigm in cell biology. The iPS invention has brought a lot of hope in terms of potential direct benefits to treat several diseases, which have no definite options at the moment. But, we envisage that several spin-offs could come out of this invention and one very significant spin-off finding recently witnessed is the finding by Prof. Masaharu Seno and his team of researchers at the Okayama University, Japan (Chen L, et al. 2012, PLoS ONE 7(4:e33544.doi:10.1371/journal.pone.0033544. According to Prof. Seno, mouse iPS cells (miPS when cultured in the conditioned medium derived from cancer cell lines, differentiate into cancer stem cells (CSCs. While differentiating into CSCs, they do retain the potential to develop endothelial progenitor cells. Several questions arise here: 1.Are these miPS derived CSCs really pluripotent, even if the terminal differentiation destined to specific phenotypes? 2.Shouldn’t the Cancer Stem Cells be termed as cancer progenitor cells, as till date they are considered to be producing only cancer cells but not pluripotent to yield other types of normal tissues? The spin-offs could be infinite as the process of differentiation and de-differentiation happening due to trillions of signals and pathways, most still remaining not-so-well understood. A special mention should be made to Prof. Shinya Yamanaka as he has several sterling qualities to be a role-model for budding scientists. Apart from his passion for science, which made him shift his career from orthopedics to a cell biologist, his

  2. Surface and groundwater quality assessment based on multivariate statistical techniques in the vicinity of Mohanpur, Bangladesh

    Directory of Open Access Journals (Sweden)

    Md. Mahtab Ali Molla

    2015-01-01

    Full Text Available Aims: This work evaluated the surface and groundwater quality of Mohanpur area, Rajshahi district, Bangladesh. Multivariate statistical techniques were also applied to determine the possible sources of water contamination. Materials and Methods: Water samples were collected from randomly selected ten different sampling sites for analyzing the chemical parameters including pH, electrical conductivity, total dissolved solids, total hardness, total alkalinity, Cl− , NO3− and some heavy metals such as Mn, Pb, Cd, and As concentrations. Concentrations of heavy metals were determined using atomic absorption spectrometer (AAS. Results: Based on hydrochemical characteristics, surface and groundwater in the study area were, in general, fresh, hard, and alkaline in nature. All chemical parameters were within the WHO water quality guidelines. Whereas, among four analyzed heavy metals Pb, and Cd concentrations exceeded the WHO recommended values. Pearson correlation matrix showed a number of statistically significant associations (P < 0.01 and P < 0.05 among the examined water quality parameters. Moreover, principal component (PC analysis (PCA and cluster analysis (CA were used to analyze the water quality dataset. PCA analysis identified two PCs as responsible for the data structure explaining 72.53% of the total variance in water quality. PCA indicated that the water quality variations were mainly of anthropogenic origin through agricultural and municipal discharges. Results of CA revealed three significant groups of similarity among the 10 sampling sites. Conclusions: It could be deduced from the present results that water contamination was occurred to some extent throughout the area, and is likely to be continued in the near future. Improvement of local sanitation system along with frequent training and awareness programs can help in developing water quality in the studied area.

  3. A statistical technique for defining rainfall forecast probabilities in southern Africa

    Science.gov (United States)

    Husak, G. J.; Magadzire, T.

    2010-12-01

    Probabilistic forecasts are currently produced by many climate centers and by just as many processes. These models use a number of inputs to generate the probability of rainfall falling in the lower/middle/upper tercile (frequently termed “below-normal”/”normal”/”above-normal”) of the historical rainfall distribution. Generation of forecasts for a season may be the result of a dynamic climate model, a statistical model, a consensus of a panel of experts, or a combination of some of the afore-mentioned techniques, among others. This last method is one most commonly accepted in Southern Africa, resulting from the Southern Africa Regional Climate Outlook Forum (SARCOF). While it has been noted that there is a reasonable chance of polygons having a dominant tercile of 60% probability or more, this has seldom been the case. Indeed, over the last four years, the SARCOF process has not produced any polygons with such a likelihood. In fact, the terciles in all of the SARCOFs since 2007 have been some combination of 40%, 35% and 25%. Discussions with SARCOF scientists suggests that the SARCOF process is currently using the probabilistic format to define relatively qualitative, rank-ordered outcomes in the format “most-likely”, “second-most likely” and “least likely” terciles. While this rank-ordered classification has its merits, it limits the sort of downstream quantitative statistical analysis that could potentially be of assistance to various decision makers. In this study we build a simple statistical model to analyze the probabilistic outcomes for the coming rainfall season, and analyze their resulting probabilities. The prediction model takes a similar approach to that already used in the SARCOF process: namely, using available historic rainfall data and SST information to create a linear regression between rainfall and SSTs, define a likely rainfall outcome, and analyze the cross-validation errors over the most recent 30 years. The cross

  4. Modelling and analysing track cycling Omnium performances using statistical and machine learning techniques.

    Science.gov (United States)

    Ofoghi, Bahadorreza; Zeleznikow, John; Dwyer, Dan; Macmahon, Clare

    2013-01-01

    This article describes the utilisation of an unsupervised machine learning technique and statistical approaches (e.g., the Kolmogorov-Smirnov test) that assist cycling experts in the crucial decision-making processes for athlete selection, training, and strategic planning in the track cycling Omnium. The Omnium is a multi-event competition that will be included in the summer Olympic Games for the first time in 2012. Presently, selectors and cycling coaches make decisions based on experience and intuition. They rarely have access to objective data. We analysed both the old five-event (first raced internationally in 2007) and new six-event (first raced internationally in 2011) Omniums and found that the addition of the elimination race component to the Omnium has, contrary to expectations, not favoured track endurance riders. We analysed the Omnium data and also determined the inter-relationships between different individual events as well as between those events and the final standings of riders. In further analysis, we found that there is no maximum ranking (poorest performance) in each individual event that riders can afford whilst still winning a medal. We also found the required times for riders to finish the timed components that are necessary for medal winning. The results of this study consider the scoring system of the Omnium and inform decision-making toward successful participation in future major Omnium competitions.

  5. Renormalization group theory outperforms other approaches in statistical comparison between upscaling techniques for porous media

    Science.gov (United States)

    Hanasoge, Shravan; Agarwal, Umang; Tandon, Kunj; Koelman, J. M. Vianney A.

    2017-09-01

    Determining the pressure differential required to achieve a desired flow rate in a porous medium requires solving Darcy's law, a Laplace-like equation, with a spatially varying tensor permeability. In various scenarios, the permeability coefficient is sampled at high spatial resolution, which makes solving Darcy's equation numerically prohibitively expensive. As a consequence, much effort has gone into creating upscaled or low-resolution effective models of the coefficient while ensuring that the estimated flow rate is well reproduced, bringing to the fore the classic tradeoff between computational cost and numerical accuracy. Here we perform a statistical study to characterize the relative success of upscaling methods on a large sample of permeability coefficients that are above the percolation threshold. We introduce a technique based on mode-elimination renormalization group theory (MG) to build coarse-scale permeability coefficients. Comparing the results with coefficients upscaled using other methods, we find that MG is consistently more accurate, particularly due to its ability to address the tensorial nature of the coefficients. MG places a low computational demand, in the manner in which we have implemented it, and accurate flow-rate estimates are obtained when using MG-upscaled permeabilities that approach or are beyond the percolation threshold.

  6. Statistical inference on associated fertility life table parameters using jackknife technique: computational aspects.

    Science.gov (United States)

    Maia, A de H; Luiz, A J; Campanhola, C

    2000-04-01

    Knowledge of population growth potential is crucial for studying population dynamics and for establishing management tactics for pest control. Estimation of population growth can be achieved with fertility life tables because they synthesize data on reproduction and mortality of a population. The five main parameters associated with a fertility life table are as follows: (1) the net reproductive rate (Ro), (2) the intrinsic rate of increase (rm), 3) the mean generation time (T), (4) the doubling time (Dt), and (5) the finite rate of increase (lambda). Jackknife and bootstrap techniques are used to calculate the variance of the rm estimate, which can be extended to the other parameters of life tables. Those methods are computer-intensive, their application requires the development of efficient algorithms, and their implementation is based on a programming language that encompasses quickness and reliability. The objectives of this article are to discuss statistical and computational aspects related to estimation of life table parameters and to present a SAS program that uses jackknife to estimate parameters for fertility life tables. The SAS program presented here allows the calculation of confidence intervals for all estimated parameters, as well as provides one-sided and two-sided t-tests to perform pairwise or multiple comparison between groups, with their respective P values.

  7. Evaluation of significantly modified water bodies in Vojvodina by using multivariate statistical techniques

    Directory of Open Access Journals (Sweden)

    Vujović Svetlana R.

    2013-01-01

    Full Text Available This paper illustrates the utility of multivariate statistical techniques for analysis and interpretation of water quality data sets and identification of pollution sources/factors with a view to get better information about the water quality and design of monitoring network for effective management of water resources. Multivariate statistical techniques, such as factor analysis (FA/principal component analysis (PCA and cluster analysis (CA, were applied for the evaluation of variations and for the interpretation of a water quality data set of the natural water bodies obtained during 2010 year of monitoring of 13 parameters at 33 different sites. FA/PCA attempts to explain the correlations between the observations in terms of the underlying factors, which are not directly observable. Factor analysis is applied to physico-chemical parameters of natural water bodies with the aim classification and data summation as well as segmentation of heterogeneous data sets into smaller homogeneous subsets. Factor loadings were categorized as strong and moderate corresponding to the absolute loading values of >0.75, 0.75-0.50, respectively. Four principal factors were obtained with Eigenvalues >1 summing more than 78 % of the total variance in the water data sets, which is adequate to give good prior information regarding data structure. Each factor that is significantly related to specific variables represents a different dimension of water quality. The first factor F1 accounting for 28 % of the total variance and represents the hydrochemical dimension of water quality. The second factor F2 accounting for 18% of the total variance and may be taken factor of water eutrophication. The third factor F3 accounting 17 % of the total variance and represents the influence of point sources of pollution on water quality. The fourth factor F4 accounting 13 % of the total variance and may be taken as an ecological dimension of water quality. Cluster analysis (CA is an

  8. Statistical Mechanics Ideas and Techniques Applied to Selected Problems in Ecology

    Directory of Open Access Journals (Sweden)

    Hugo Fort

    2013-11-01

    Full Text Available Ecosystem dynamics provides an interesting arena for the application of a plethora concepts and techniques from statistical mechanics. Here I review three examples corresponding each one to an important problem in ecology. First, I start with an analytical derivation of clumpy patterns for species relative abundances (SRA empirically observed in several ecological communities involving a high number n of species, a phenomenon which have puzzled ecologists for decades. An interesting point is that this derivation uses results obtained from a statistical mechanics model for ferromagnets. Second, going beyond the mean field approximation, I study the spatial version of a popular ecological model involving just one species representing vegetation. The goal is to address the phenomena of catastrophic shifts—gradual cumulative variations in some control parameter that suddenly lead to an abrupt change in the system—illustrating it by means of the process of desertification of arid lands. The focus is on the aggregation processes and the effects of diffusion that combined lead to the formation of non trivial spatial vegetation patterns. It is shown that different quantities—like the variance, the two-point correlation function and the patchiness—may serve as early warnings for the desertification of arid lands. Remarkably, in the onset of a desertification transition the distribution of vegetation patches exhibits scale invariance typical of many physical systems in the vicinity a phase transition. I comment on similarities of and differences between these catastrophic shifts and paradigmatic thermodynamic phase transitions like the liquid-vapor change of state for a fluid. Third, I analyze the case of many species interacting in space. I choose tropical forests, which are mega-diverse ecosystems that exhibit remarkable dynamics. Therefore these ecosystems represent a research paradigm both for studies of complex systems dynamics as well as to

  9. Application of multivariate statistical technique for hydrogeochemical assessment of groundwater within the Lower Pra Basin, Ghana

    Science.gov (United States)

    Tay, C. K.; Hayford, E. K.; Hodgson, I. O. A.

    2017-06-01

    Multivariate statistical technique and hydrogeochemical approach were employed for groundwater assessment within the Lower Pra Basin. The main objective was to delineate the main processes that are responsible for the water chemistry and pollution of groundwater within the basin. Fifty-four (54) (No) boreholes were sampled in January 2012 for quality assessment. PCA using Varimax with Kaiser Normalization method of extraction for both rotated space and component matrix have been applied to the data. Results show that Spearman's correlation matrix of major ions revealed expected process-based relationships derived mainly from the geochemical processes, such as ion-exchange and silicate/aluminosilicate weathering within the aquifer. Three main principal components influence the water chemistry and pollution of groundwater within the basin. The three principal components have accounted for approximately 79% of the total variance in the hydrochemical data. Component 1 delineates the main natural processes (water-soil-rock interactions) through which groundwater within the basin acquires its chemical characteristics, Component 2 delineates the incongruent dissolution of silicate/aluminosilicates, while Component 3 delineates the prevalence of pollution principally from agricultural input as well as trace metal mobilization in groundwater within the basin. The loadings and score plots of the first two PCs show grouping pattern which indicates the strength of the mutual relation among the hydrochemical variables. In terms of proper management and development of groundwater within the basin, communities, where intense agriculture is taking place, should be monitored and protected from agricultural activities. especially where inorganic fertilizers are used by creating buffer zones. Monitoring of the water quality especially the water pH is recommended to ensure the acid neutralizing potential of groundwater within the basin thereby, curtailing further trace metal

  10. Source Identification of Heavy Metals in Soils Surrounding the Zanjan Zinc Town by Multivariate Statistical Techniques

    Directory of Open Access Journals (Sweden)

    M.A. Delavar

    2016-02-01

    Full Text Available Introduction: The accumulation of heavy metals (HMs in the soil is of increasing concern due to food safety issues, potential health risks, and the detrimental effects on soil ecosystems. HMs may be considered as the most important soil pollutants, because they are not biodegradable and their physical movement through the soil profile is relatively limited. Therefore, root uptake process may provide a big chance for these pollutants to transfer from the surface soil to natural and cultivated plants, which may eventually steer them to human bodies. The general behavior of HMs in the environment, especially their bioavailability in the soil, is influenced by their origin. Hence, source apportionment of HMs may provide some essential information for better management of polluted soils to restrict the HMs entrance to the human food chain. This paper explores the applicability of multivariate statistical techniques in the identification of probable sources that can control the concentration and distribution of selected HMs in the soils surrounding the Zanjan Zinc Specialized Industrial Town (briefly Zinc Town. Materials and Methods: The area under investigation has a size of approximately 4000 ha.It is located around the Zinc Town, Zanjan province. A regular grid sampling pattern with an interval of 500 meters was applied to identify the sample location, and 184 topsoil samples (0-10 cm were collected. The soil samples were air-dried and sieved through a 2 mm polyethylene sieve and then, were digested using HNO3. The total concentrations of zinc (Zn, lead (Pb, cadmium (Cd, Nickel (Ni and copper (Cu in the soil solutions were determined via Atomic Absorption Spectroscopy (AAS. Data were statistically analyzed using the SPSS software version 17.0 for Windows. Correlation Matrix (CM, Principal Component Analyses (PCA and Factor Analyses (FA techniques were performed in order to identify the probable sources of HMs in the studied soils. Results and

  11. The adaptive statistical iterative reconstruction-V technique for radiation dose reduction in abdominal CT: comparison with the adaptive statistical iterative reconstruction technique

    Science.gov (United States)

    Cho, Jinhan; Oh, Jongyeong; Kim, Dongwon; Cho, Junghyun; Kim, Sanghyun; Lee, Sangyun; Lee, Jihyun

    2015-01-01

    Objective: To investigate whether reduced radiation dose abdominal CT images reconstructed with adaptive statistical iterative reconstruction V (ASIR-V) compromise the depiction of clinically competent features when compared with the currently used routine radiation dose CT images reconstructed with ASIR. Methods: 27 consecutive patients (mean body mass index: 23.55 kg m−2 underwent CT of the abdomen at two time points. At the first time point, abdominal CT was scanned at 21.45 noise index levels of automatic current modulation at 120 kV. Images were reconstructed with 40% ASIR, the routine protocol of Dong-A University Hospital. At the second time point, follow-up scans were performed at 30 noise index levels. Images were reconstructed with filtered back projection (FBP), 40% ASIR, 30% ASIR-V, 50% ASIR-V and 70% ASIR-V for the reduced radiation dose. Both quantitative and qualitative analyses of image quality were conducted. The CT dose index was also recorded. Results: At the follow-up study, the mean dose reduction relative to the currently used common radiation dose was 35.37% (range: 19–49%). The overall subjective image quality and diagnostic acceptability of the 50% ASIR-V scores at the reduced radiation dose were nearly identical to those recorded when using the initial routine-dose CT with 40% ASIR. Subjective ratings of the qualitative analysis revealed that of all reduced radiation dose CT series reconstructed, 30% ASIR-V and 50% ASIR-V were associated with higher image quality with lower noise and artefacts as well as good sharpness when compared with 40% ASIR and FBP. However, the sharpness score at 70% ASIR-V was considered to be worse than that at 40% ASIR. Objective image noise for 50% ASIR-V was 34.24% and 46.34% which was lower than 40% ASIR and FBP. Conclusion: Abdominal CT images reconstructed with ASIR-V facilitate radiation dose reductions of to 35% when compared with the ASIR. Advances in knowledge: This study represents the first

  12. The adaptive statistical iterative reconstruction-V technique for radiation dose reduction in abdominal CT: comparison with the adaptive statistical iterative reconstruction technique.

    Science.gov (United States)

    Kwon, Heejin; Cho, Jinhan; Oh, Jongyeong; Kim, Dongwon; Cho, Junghyun; Kim, Sanghyun; Lee, Sangyun; Lee, Jihyun

    2015-10-01

    To investigate whether reduced radiation dose abdominal CT images reconstructed with adaptive statistical iterative reconstruction V (ASIR-V) compromise the depiction of clinically competent features when compared with the currently used routine radiation dose CT images reconstructed with ASIR. 27 consecutive patients (mean body mass index: 23.55 kg m(-2) underwent CT of the abdomen at two time points. At the first time point, abdominal CT was scanned at 21.45 noise index levels of automatic current modulation at 120 kV. Images were reconstructed with 40% ASIR, the routine protocol of Dong-A University Hospital. At the second time point, follow-up scans were performed at 30 noise index levels. Images were reconstructed with filtered back projection (FBP), 40% ASIR, 30% ASIR-V, 50% ASIR-V and 70% ASIR-V for the reduced radiation dose. Both quantitative and qualitative analyses of image quality were conducted. The CT dose index was also recorded. At the follow-up study, the mean dose reduction relative to the currently used common radiation dose was 35.37% (range: 19-49%). The overall subjective image quality and diagnostic acceptability of the 50% ASIR-V scores at the reduced radiation dose were nearly identical to those recorded when using the initial routine-dose CT with 40% ASIR. Subjective ratings of the qualitative analysis revealed that of all reduced radiation dose CT series reconstructed, 30% ASIR-V and 50% ASIR-V were associated with higher image quality with lower noise and artefacts as well as good sharpness when compared with 40% ASIR and FBP. However, the sharpness score at 70% ASIR-V was considered to be worse than that at 40% ASIR. Objective image noise for 50% ASIR-V was 34.24% and 46.34% which was lower than 40% ASIR and FBP. Abdominal CT images reconstructed with ASIR-V facilitate radiation dose reductions of to 35% when compared with the ASIR. This study represents the first clinical research experiment to use ASIR-V, the newest version of

  13. SPS and PS Experiments Committee

    CERN Multimedia

    CERN. Geneva

    2004-01-01

    OPEN SESSION: 09:00 Status report of NA58 / COMPASS: A. Magnon 09:40 Status report of PS212 / DIRAC: L. Tausher 10:10 PS212 / DIRAC Addendum: L. Nemenov CLOSED SESSION on Tuesday, 27 April 2004 after the open session, Main Building, 6th floor conference room

  14. Abdominal CT: comparison of adaptive statistical iterative and filtered back projection reconstruction techniques.

    Science.gov (United States)

    Singh, Sarabjeet; Kalra, Mannudeep K; Hsieh, Jiang; Licato, Paul E; Do, Synho; Pien, Homer H; Blake, Michael A

    2010-11-01

    To compare image quality and lesion conspicuity on abdominal computed tomographic (CT) images acquired with different x-ray tube current-time products (50-200 mAs) and reconstructed with adaptive statistical iterative reconstruction (ASIR) and filtered back projection (FBP) techniques. Twenty-two patients (mean age, 60.1 years ± 7.3 [standard deviation]; age range, 52.8-67.4 years; mean weight, 78.9 kg ± 18.3; 12 men, 10 women) gave informed consent for this prospective institutional review board-approved and HIPAA-compliant study, which involved the acquisition of four additional image series at multidetector CT. Images were acquired at different tube current-time products (200, 150, 100, and 50 mAs) and encompassed an abdominal lesion over a 10-cm scan length. Images were reconstructed separately with FBP and with three levels of ASIR-FBP blending. Two radiologists reviewed FBP and ASIR images for image quality in a blinded and randomized manner. Volume CT dose index (CTDI(vol)), dose-length product, patient weight, objective noise, and CT numbers were recorded. Data were analyzed by using analysis of variance and the Wilcoxon signed rank test. CTDI(vol) values were 16.8, 12.6, 8.4, and 4.2 mGy for 200, 150, 100, and 50 mAs, respectively (P 22 image series acquired at 4.2 mGy with 70% ASIR. Lesion conspicuity was significantly better at 4.2 mGy on ASIR than on FBP images (observed P < .044), and overall diagnostic confidence changed from unacceptable on FBP to acceptable on ASIR images. ASIR lowers noise and improves diagnostic confidence in and conspicuity of subtle abdominal lesions at 8.4 mGy when images are reconstructed with 30% ASIR blending and at 4.2 mGy in patients weighing 90 kg or less when images are reconstructed with 50% or 70% ASIR blending. © RSNA, 2010.

  15. Assessment of roadside surface water quality of Savar, Dhaka, Bangladesh using GIS and multivariate statistical techniques

    Science.gov (United States)

    Ahmed, Fahad; Fakhruddin, A. N. M.; Imam, MD. Toufick; Khan, Nasima; Abdullah, Abu Tareq Mohammad; Khan, Tanzir Ahmed; Rahman, Md. Mahfuzur; Uddin, Mohammad Nashir

    2017-11-01

    In this study, multivariate statistical techniques in collaboration with GIS are used to assess the roadside surface water quality of Savar region. Nineteen water samples were collected in dry season and 15 water quality parameters including TSS, TDS, pH, DO, BOD, Cl-, F-, NO3 2-, NO2 -, SO4 2-, Ca, Mg, K, Zn and Pb were measured. The univariate overview of water quality parameters are TSS 25.154 ± 8.674 mg/l, TDS 840.400 ± 311.081 mg/l, pH 7.574 ± 0.256 pH unit, DO 4.544 ± 0.933 mg/l, BOD 0.758 ± 0.179 mg/l, Cl- 51.494 ± 28.095 mg/l, F- 0.771 ± 0.153 mg/l, NO3 2- 2.211 ± 0.878 mg/l, NO2 - 4.692 ± 5.971 mg/l, SO4 2- 69.545 ± 53.873 mg/l, Ca 48.458 ± 22.690 mg/l, Mg 19.676 ± 7.361 mg/l, K 12.874 ± 11.382 mg/l, Zn 0.027 ± 0.029 mg/l, Pb 0.096 ± 0.154 mg/l. The water quality data were subjected to R-mode PCA which resulted in five major components. PC1 explains 28% of total variance and indicates the roadside and brick field dust settle down (TDS, TSS) in the nearby water body. PC2 explains 22.123% of total variance and indicates the agricultural influence (K, Ca, and NO2 -). PC3 describes the contribution of nonpoint pollution from agricultural and soil erosion processes (SO4 2-, Cl-, and K). PC4 depicts heavy positively loaded by vehicle emission and diffusion from battery stores (Zn, Pb). PC5 depicts strong positive loading of BOD and strong negative loading of pH. Cluster analysis represents three major clusters for both water parameters and sampling sites. The site based on cluster showed similar grouping pattern of R-mode factor score map. The present work reveals a new scope to monitor the roadside water quality for future research in Bangladesh.

  16. Assessment of roadside surface water quality of Savar, Dhaka, Bangladesh using GIS and multivariate statistical techniques

    Science.gov (United States)

    Ahmed, Fahad; Fakhruddin, A. N. M.; Imam, MD. Toufick; Khan, Nasima; Abdullah, Abu Tareq Mohammad; Khan, Tanzir Ahmed; Rahman, Md. Mahfuzur; Uddin, Mohammad Nashir

    2017-09-01

    In this study, multivariate statistical techniques in collaboration with GIS are used to assess the roadside surface water quality of Savar region. Nineteen water samples were collected in dry season and 15 water quality parameters including TSS, TDS, pH, DO, BOD, Cl-, F-, NO3 2-, NO2 -, SO4 2-, Ca, Mg, K, Zn and Pb were measured. The univariate overview of water quality parameters are TSS 25.154 ± 8.674 mg/l, TDS 840.400 ± 311.081 mg/l, pH 7.574 ± 0.256 pH unit, DO 4.544 ± 0.933 mg/l, BOD 0.758 ± 0.179 mg/l, Cl- 51.494 ± 28.095 mg/l, F- 0.771 ± 0.153 mg/l, NO3 2- 2.211 ± 0.878 mg/l, NO2 - 4.692 ± 5.971 mg/l, SO4 2- 69.545 ± 53.873 mg/l, Ca 48.458 ± 22.690 mg/l, Mg 19.676 ± 7.361 mg/l, K 12.874 ± 11.382 mg/l, Zn 0.027 ± 0.029 mg/l, Pb 0.096 ± 0.154 mg/l. The water quality data were subjected to R-mode PCA which resulted in five major components. PC1 explains 28% of total variance and indicates the roadside and brick field dust settle down (TDS, TSS) in the nearby water body. PC2 explains 22.123% of total variance and indicates the agricultural influence (K, Ca, and NO2 -). PC3 describes the contribution of nonpoint pollution from agricultural and soil erosion processes (SO4 2-, Cl-, and K). PC4 depicts heavy positively loaded by vehicle emission and diffusion from battery stores (Zn, Pb). PC5 depicts strong positive loading of BOD and strong negative loading of pH. Cluster analysis represents three major clusters for both water parameters and sampling sites. The site based on cluster showed similar grouping pattern of R-mode factor score map. The present work reveals a new scope to monitor the roadside water quality for future research in Bangladesh.

  17. An evaluation of multivariate statistical techniques for the analysis of yield from barley (Hordeum vulgare L.) breeding trials data

    OpenAIRE

    ABDULLAH, AHMED

    2007-01-01

    This project involved two locations (Breda and Tel Hadya) over two seasons (1993 and 1994). Yield was found to have been affected by many factors including environment, genotype and morphological characters. A genotype-environment interaction (GEl) was also discovered. To investigate the influence of morphological characters on yield parameters, multivariate statistical techniques (canonical analysis, factor analysis and multiple regression analysis (linear and exponentia...

  18. Fraudulent Financial Statement Detection Using Statistical Techniques: The Case of Small Medium Automotive Enterprise

    National Research Council Canada - National Science Library

    Nooraslinda Abdul Aris; Siti Maznah Mohd Arif; Rohana Othman; Mustafa Mohamed Zain

    2015-01-01

    ...). Small and medium sized businesses are also threatened by fraudulent activities and statistics showed organizations with fewer than 100 employees experienced more fraud cases than larger corporations (ACFE, 2008...

  19. Preparing systems engineering and computing science students in disciplined methods, quantitative, and advanced statistical techniques to improve process performance

    Science.gov (United States)

    McCray, Wilmon Wil L., Jr.

    The research was prompted by a need to conduct a study that assesses process improvement, quality management and analytical techniques taught to students in U.S. colleges and universities undergraduate and graduate systems engineering and the computing science discipline (e.g., software engineering, computer science, and information technology) degree programs during their academic training that can be applied to quantitatively manage processes for performance. Everyone involved in executing repeatable processes in the software and systems development lifecycle processes needs to become familiar with the concepts of quantitative management, statistical thinking, process improvement methods and how they relate to process-performance. Organizations are starting to embrace the de facto Software Engineering Institute (SEI) Capability Maturity Model Integration (CMMI RTM) Models as process improvement frameworks to improve business processes performance. High maturity process areas in the CMMI model imply the use of analytical, statistical, quantitative management techniques, and process performance modeling to identify and eliminate sources of variation, continually improve process-performance; reduce cost and predict future outcomes. The research study identifies and provides a detail discussion of the gap analysis findings of process improvement and quantitative analysis techniques taught in U.S. universities systems engineering and computing science degree programs, gaps that exist in the literature, and a comparison analysis which identifies the gaps that exist between the SEI's "healthy ingredients " of a process performance model and courses taught in U.S. universities degree program. The research also heightens awareness that academicians have conducted little research on applicable statistics and quantitative techniques that can be used to demonstrate high maturity as implied in the CMMI models. The research also includes a Monte Carlo simulation optimization

  20. Statistical Techniques for Analyzing Process or "Similarity" Data in TID Hardness Assurance

    Science.gov (United States)

    Ladbury, R.

    2010-01-01

    We investigate techniques for estimating the contributions to TID hardness variability for families of linear bipolar technologies, determining how part-to-part and lot-to-lot variability change for different part types in the process.

  1. A Decision Tree Approach to the Interpretation of Multivariate Statistical Techniques.

    Science.gov (United States)

    Fok, Lillian Y.; And Others

    1995-01-01

    Discusses the nature, power, and limitations of four multivariate techniques: factor analysis, multiple analysis of variance, multiple regression, and multiple discriminant analysis. Shows how decision trees assist in interpreting results. (SK)

  2. Multivariate statistical techniques for the evaluation of surface water quality of the Himalayan foothills streams, Pakistan

    National Research Council Canada - National Science Library

    Malik, Riffat Naseem; Hashmi, Muhammad Zaffar

    2017-01-01

    ...; thus, the water quality is closely related to public health. Multivariate techniques were applied to check spatial and seasonal trends, and metals contamination sources of the Himalayan foothills streams, Pakistan...

  3. An evaluation of statistical process control techniques applied to blood component quality monitoring with particular reference to CUSUM.

    Science.gov (United States)

    Nightingale, M J; Madden, S; Curnow, E; Collett, D; Procter, S; Rowe, G P

    2012-08-01

    Statistical process control (SPC) is used to monitor the performance of blood component collection and production processes in the UK and elsewhere. The sensitivity of the applied technique(s) needs to be matched to the clinical importance of the parameter being monitored such that significant deviations in the process mean and/or variability of critical parameters (e.g. the leucocyte content of leucodepleted components) are detected and investigated immediately. This study assessed the sensitivity and specificity of a range of techniques for variable and attribute (proportion non-conforming) data. Comparison was based on a range of simulated and 'live' blood component quality monitoring data including X/R, cumulative sum (CUSUM) procedures, the scan statistic and np charts. X/R and CUSUM could detect shifts of two standard deviations in the process mean within 5 days. Current leucocyte count data (substantially skewed even after log transformation) was found to be better suited to attribute analysis. CUSUM alone was able to detect shifts on the same day when based on 20 or more samples and achieved acceptable specificity. CUSUM procedures for proportion non-conforming can usefully augment existing X/R techniques for leucodepletion monitoring, provide valid control limits and the required sensitivity. The scan statistic and 'np' charts offered no obvious advantages. © 2012 The Authors. Transfusion Medicine © 2012 British Blood Transfusion Society.

  4. Visual Analysis of North Atlantic Hurricane Trends Using Parallel Coordinates and Statistical Techniques

    National Research Council Canada - National Science Library

    Steed, Chad A; Fitzpatrick, Patrick J; Jankun-Kelly, T. J; Swan II, J. E

    2008-01-01

    ... for a particular dependent variable. These capabilities are combined into a unique visualization system that is demonstrated via a North Atlantic hurricane climate study using a systematic workflow. This research corroborates the notion that enhanced parallel coordinates coupled with statistical analysis can be used for more effective knowledge discovery and confirmation in complex, real-world data sets.

  5. The Random Forests Statistical Technique: An Examination of Its Value for the Study of Reading

    Science.gov (United States)

    Matsuki, Kazunaga; Kuperman, Victor; Van Dyke, Julie A.

    2016-01-01

    Studies investigating individual differences in reading ability often involve data sets containing a large number of collinear predictors and a small number of observations. In this article, we discuss the method of Random Forests and demonstrate its suitability for addressing the statistical concerns raised by such data sets. The method is…

  6. Vibration impact acoustic emission technique for identification and analysis of defects in carbon steel tubes: Part A Statistical analysis

    Energy Technology Data Exchange (ETDEWEB)

    Halim, Zakiah Abd [Universiti Teknikal Malaysia Melaka (Malaysia); Jamaludin, Nordin; Junaidi, Syarif [Faculty of Engineering and Built, Universiti Kebangsaan Malaysia, Bangi (Malaysia); Yahya, Syed Yusainee Syed [Universiti Teknologi MARA, Shah Alam (Malaysia)

    2015-04-15

    Current steel tubes inspection techniques are invasive, and the interpretation and evaluation of inspection results are manually done by skilled personnel. This paper presents a statistical analysis of high frequency stress wave signals captured from a newly developed noninvasive, non-destructive tube inspection technique known as the vibration impact acoustic emission (VIAE) technique. Acoustic emission (AE) signals have been introduced into the ASTM A179 seamless steel tubes using an impact hammer, and the AE wave propagation was captured using an AE sensor. Specifically, a healthy steel tube as the reference tube and four steel tubes with through-hole artificial defect at different locations were used in this study. The AE features extracted from the captured signals are rise time, peak amplitude, duration and count. The VIAE technique also analysed the AE signals using statistical features such as root mean square (r.m.s.), energy, and crest factor. It was evident that duration, count, r.m.s., energy and crest factor could be used to automatically identify the presence of defect in carbon steel tubes using AE signals captured using the non-invasive VIAE technique.

  7. Under the influence of Malthus's law of population growth: Darwin eschews the statistical techniques of Aldolphe Quetelet.

    Science.gov (United States)

    Ariew, André

    2007-03-01

    Charles Darwin, James Clerk Maxwell, and Francis Galton were all aware, by various means, of Aldolphe Quetelet's pioneering work in statistics. Darwin, Maxwell, and Galton all had reason to be interested in Quetelet's work: they were all working on some instance of how large-scale regularities emerge from individual events that vary from one another; all were rejecting the divine interventionistic theories of their contemporaries; and Quetelet's techniques provided them with a way forward. Maxwell and Galton all explicitly endorse Quetelet's techniques in their work; Darwin does not incorporate any of the statistical ideas of Quetelet, although natural selection post-twentieth century synthesis has. Why not Darwin? My answer is that by the time Darwin encountered Malthus's law of excess reproduction he had all he needed to answer about large scale regularities in extinctions, speciation, and adaptation. He didn't need Quetelet.

  8. Structural and statistical properties of the collocation technique for error characterization

    Directory of Open Access Journals (Sweden)

    S. Zwieback

    2012-02-01

    Full Text Available The validation of geophysical data sets (e.g. derived from models, exploration techniques or remote sensing presents a formidable challenge as all products are inherently different and subject to errors. The collocation technique permits the retrieval of the error variances of different data sources without the need to specify one data set as a reference. In addition calibration constants can be determined to account for biases and different dynamic ranges. The method is frequently applied to the study and comparison of remote sensing, in-situ and modelled data, particularly in hydrology and oceanography. Previous studies have almost exclusively focussed on the validation of three data sources; in this paper it is shown how the technique generalizes to an arbitrary number of data sets. It turns out that only parts of the covariance structure can be resolved by the collocation technique, thus emphasizing the necessity of expert knowledge for the correct validation of geophysical products. Furthermore the bias and error variance of the estimators are derived with particular emphasis on the assumptions necessary for establishing those characteristics. Important properties of the method, such as the structural deficiencies, dependence of the accuracy on the number of measurements and the impact of violated assumptions, are illustrated by application to simulated data.

  9. Statistical considerations and techniques for understanding physiological data, modeling, and treatments.

    Science.gov (United States)

    Fitzpatrick, Ben G

    2008-06-01

    Comparing models with data always forces us to deal with uncertainty. This uncertainty may take many different forms and involve multiple scales of resolution in the model and in the experiment. In this paper, we discuss issues surrounding the development of deterministic dynamic models of mean behavior and the associated statistical models of the difference between model and experiment. We touch on a variety of topics, including basic exploratory data analysis, confidence bounds and model reduction hypothesis tests. Tools ranging from nonlinear regression to time series to Bayesian decision theory are presented.

  10. Application of statistical techniques for elucidating flow cytometric data of batch and fed-batch cultures.

    Science.gov (United States)

    Shirsat, Nishikant; Avesh, Mohd; English, Niall J; Glennon, Brian; Al-Rubeai, Mohamed

    2013-01-01

    The objective of this work is to develop structured, segregated stochastic models for bioprocesses using time-series flow cytometric (FC) data. To this end, mammalian CHO cells were grown in both batch and fed-batch cultures, and their viable cell numbers (VCDs), monoclonal antibody (MAb), cell cycle phases, mitochondria membrane potential/mitochondria mass, Golgi apparatus, and endoplasmic reticulum (ER) were analyzed. For the fed-batch mode, soy hydrolysate was introduced at 24-H intervals. The cytometric data were analyzed for early indicators of growth and productivity by multiple linear regression analysis, which involved taking into account multicollinearity diagnostics, Durbin-Watson statistics, and Houston tests to determine and refine statistically significant correlations between categorical variables (FC parameters) and response variables (yield parameters). The results indicate that the percentage of G1 cells and ER was significantly correlated with VCD and MAb in the case of batch culture, whereas for fed-batch culture, the percentage of G2 cells and ER was correlated significantly. There was a significant difference between cells in the batch and fed-batch cultures in their ER content, suggesting that the increase in protein synthesis as reflected by the ER content and consequent increase in growth rate and MAb productivity both can be monitored at the cellular level by FC analysis of ER content. © 2013 International Union of Biochemistry and Molecular Biology, Inc.

  11. Application of the Statistical ICA Technique in the DANCE Data Analysis

    Science.gov (United States)

    Baramsai, Bayarbadrakh; Jandel, M.; Bredeweg, T. A.; Rusev, G.; Walker, C. L.; Couture, A.; Mosby, S.; Ullmann, J. L.; Dance Collaboration

    2015-10-01

    The Detector for Advanced Neutron Capture Experiments (DANCE) at the Los Alamos Neutron Science Center is used to improve our understanding of the neutron capture reaction. DANCE is a highly efficient 4 π γ-ray detector array consisting of 160 BaF2 crystals which make it an ideal tool for neutron capture experiments. The (n, γ) reaction Q-value equals to the sum energy of all γ-rays emitted in the de-excitation cascades from the excited capture state to the ground state. The total γ-ray energy is used to identify reactions on different isotopes as well as the background. However, it's challenging to identify contribution in the Esum spectra from different isotopes with the similar Q-values. Recently we have tested the applicability of modern statistical methods such as Independent Component Analysis (ICA) to identify and separate different (n, γ) reaction yields on different isotopes that are present in the target material. ICA is a recently developed computational tool for separating multidimensional data into statistically independent additive subcomponents. In this conference talk, we present some results of the application of ICA algorithms and its modification for the DANCE experimental data analysis. This research is supported by the U. S. Department of Energy, Office of Science, Nuclear Physics under the Early Career Award No. LANL20135009.

  12. Relationship between Pore-size Distribution and Flexibility of Adsorbent Materials: Statistical Mechanics and Future Material Characterization Techniques.

    Science.gov (United States)

    Siderius, Daniel W; Mahynski, Nathan A; Shen, Vincent K

    2017-05-01

    Measurement of the pore-size distribution (PSD) via gas adsorption and the so-called "kernel method" is a widely used characterization technique for rigid adsorbents. Yet, standard techniques and analytical equipment are not appropriate to characterize the emerging class of flexible adsorbents that deform in response to the stress imparted by an adsorbate gas, as the PSD is a characteristic of the material that varies with the gas pressure and any other external stresses. Here, we derive the PSD for a flexible adsorbent using statistical mechanics in the osmotic ensemble to draw analogy to the kernel method for rigid materials. The resultant PSD is a function of the ensemble constraints including all imposed stresses and, most importantly, the deformation free energy of the adsorbent material. Consequently, a pressure-dependent PSD is a descriptor of the deformation characteristics of an adsorbent and may be the basis of future material characterization techniques. We discuss how, given a technique for resolving pressure-dependent PSDs, the present statistical mechanical theory could enable a new generation of analytical tools that measure and characterize certain intrinsic material properties of flexible adsorbents via otherwise simple adsorption experiments.

  13. MDCT arthrography of the hip: value of the adaptive statistical iterative reconstruction technique and potential for radiation dose reduction.

    Science.gov (United States)

    Tobalem, Frank; Dugert, Eric; Verdun, Francis R; Dunet, Vincent; Ott, Julien G; Rudiger, Hannes A; Cherix, Stephane; Meuli, Reto; Becce, Fabio

    2014-12-01

    The purpose of this article is to assess the effect of the adaptive statistical iterative reconstruction (ASIR) technique on image quality in hip MDCT arthrography and to evaluate its potential for reducing radiation dose. Thirty-seven patients examined with hip MDCT arthrography were prospectively randomized into three different protocols: one with a regular dose (volume CT dose index [CTDIvol], 38.4 mGy) and two with a reduced dose (CTDIvol, 24.6 or 15.4 mGy). Images were reconstructed using filtered back projection (FBP) and four increasing percentages of ASIR (30%, 50%, 70%, and 90%). Image noise and contrast-to-noise ratio (CNR) were measured. Two musculoskeletal radiologists independently evaluated several anatomic structures and image quality parameters using a 4-point scale. They also jointly assessed acetabular labrum tears and articular cartilage lesions. With decreasing radiation dose level, image noise statistically significantly increased (p=0.0009) and CNR statistically significantly decreased (p=0.001). We also found a statistically significant reduction in noise (p=0.0001) and increase in CNR (p≤0.003) with increasing percentage of ASIR; in addition, we noted statistically significant increases in image quality scores for the labrum and cartilage, subchondral bone, overall diagnostic quality (up to 50% ASIR), and subjective noise (p≤0.04), and statistically significant reductions for the trabecular bone and muscles (p≤0.03). Regardless of the radiation dose level, there were no statistically significant differences in the detection and characterization of labral tears (n=24; p=1) and cartilage lesions (n=40; p≥0.89) depending on the ASIR percentage. The use of up to 50% ASIR in hip MDCT arthrography helps to reduce radiation dose by approximately 35-60%, while maintaining diagnostic image quality comparable to that of a regular-dose protocol using FBP.

  14. Source Evaluation and Trace Metal Contamination in Benthic Sediments from Equatorial Ecosystems Using Multivariate Statistical Techniques.

    Directory of Open Access Journals (Sweden)

    Nsikak U Benson

    Full Text Available Trace metals (Cd, Cr, Cu, Ni and Pb concentrations in benthic sediments were analyzed through multi-step fractionation scheme to assess the levels and sources of contamination in estuarine, riverine and freshwater ecosystems in Niger Delta (Nigeria. The degree of contamination was assessed using the individual contamination factors (ICF and global contamination factor (GCF. Multivariate statistical approaches including principal component analysis (PCA, cluster analysis and correlation test were employed to evaluate the interrelationships and associated sources of contamination. The spatial distribution of metal concentrations followed the pattern Pb>Cu>Cr>Cd>Ni. Ecological risk index by ICF showed significant potential mobility and bioavailability for Cu, Cu and Ni. The ICF contamination trend in the benthic sediments at all studied sites was Cu>Cr>Ni>Cd>Pb. The principal component and agglomerative clustering analyses indicate that trace metals contamination in the ecosystems was influenced by multiple pollution sources.

  15. Mean Normalized Force Computation for Different Types of Obstacles due to Dam Break Using Statistical Techniques

    Directory of Open Access Journals (Sweden)

    Petrus H.A.J.M van Gelder

    2013-05-01

    Full Text Available The dam-break induced loads and their effects on buildings are of vital importance for assessing the vulnerability of buildings in flood-prone areas. A comprehensive methodology, for risk assessment of buildings subject to flooding, is nevertheless still missing. This research aims to take a step forward by following previous research. To this aim, (1 five statistical procedures including: simple correlation analysis, multiple linear regression model, stepwise multiple linear regression model, principal component analysis and cluster analysis are used to study relationship between mean normalized force on structure and other related variables; (2 a new and efficient variable that can take into account both the shape of the structure and flow conditions is proposed; (3 a new and practical formula for predicting the mean normalized force is suggested for different types of obstacles, which is missing in the previous research.

  16. The detection of infant cortical auditory evoked potentials (CAEPs) using statistical and visual detection techniques.

    Science.gov (United States)

    Carter, Lyndal; Golding, Maryanne; Dillon, Harvey; Seymour, John

    2010-05-01

    With the advent of newborn hearing screening programs, the need to verify the fit of hearing aids in young infants has increased. The recording of cortical auditory evoked potentials (CAEPs) for this purpose is quite feasible, but rapid developmental changes that affect response morphology and the presence of electrophysiological noise can make subjective response detection challenging. The purpose of this study was to investigate the effectiveness of an automated statistic versus experienced examiners in detecting the presence of infant CAEPs when stimuli were present and reporting the absence of CAEPs when no stimuli were present. A repeated-measures design was used where infant-generated CAEPs were interpreted by examiners and an automated statistic. There were nine male and five female infants (mean age, 12 mo; SD, 3.4) who completed behavioral and electrophysiological testing using speech-based stimuli. In total, 87 infant CAEPs were recorded to three sensation levels, 10, 20 and 30 dB relative to the behavioral thresholds and to nonstimulus trials. Three examiners were presented with these responses: (1) "in series," where waveforms were presented in order of decreasing stimulus presentation levels, and (2) "nonseries," where waveforms were randomized completely and presented as independent waveforms. The examiners were given no information about the stimulus levels and were asked to determine whether responses to auditory stimulation could be observed and their degree of certainty in making their decision. Data from the CAEP responses were also converted to multiple dependent variables and analyzed using Hotelling's T(2). Results from both methods of response detection were analyzed using a repeated measures ANOVA (analysis of variance) and parameters of signal detection theory known as d-prime (d') and the area under the receiver operating characteristic (ROC) curve. Results showed that as the stimulus level increased, the sensitivity index, d', increased

  17. An Efficient Statistical Computation Technique for Health Care Big Data using R

    Science.gov (United States)

    Sushma Rani, N.; Srinivasa Rao, P., Dr; Parimala, P.

    2017-08-01

    Due to the changes in living conditions and other factors many critical health related problems are arising. The diagnosis of the problem at earlier stages will increase the chances of survival and fast recovery. This reduces the time of recovery and the cost associated for the treatment. One such medical related issue is cancer and breast cancer has been identified as the second leading cause of cancer death. If detected in the early stage it can be cured. Once a patient is detected with breast cancer tumor, it should be classified whether it is cancerous or non-cancerous. So the paper uses k-nearest neighbors(KNN) algorithm which is one of the simplest machine learning algorithms and is an instance-based learning algorithm to classify the data. Day-to -day new records are added which leds to increase in the data to be classified and this tends to be big data problem. The algorithm is implemented in R whichis the most popular platform applied to machine learning algorithms for statistical computing. Experimentation is conducted by using various classification evaluation metric onvarious values of k. The results show that the KNN algorithm out performes better than existing models.

  18. Assessment of Reservoir Water Quality Using Multivariate Statistical Techniques: A Case Study of Qiandao Lake, China

    Directory of Open Access Journals (Sweden)

    Qing Gu

    2016-03-01

    Full Text Available Qiandao Lake (Xin’an Jiang reservoir plays a significant role in drinking water supply for eastern China, and it is an attractive tourist destination. Three multivariate statistical methods were comprehensively applied to assess the spatial and temporal variations in water quality as well as potential pollution sources in Qiandao Lake. Data sets of nine parameters from 12 monitoring sites during 2010–2013 were obtained for analysis. Cluster analysis (CA was applied to classify the 12 sampling sites into three groups (Groups A, B and C and the 12 monitoring months into two clusters (April-July, and the remaining months. Discriminant analysis (DA identified Secchi disc depth, dissolved oxygen, permanganate index and total phosphorus as the significant variables for distinguishing variations of different years, with 79.9% correct assignments. Dissolved oxygen, pH and chlorophyll-a were determined to discriminate between the two sampling periods classified by CA, with 87.8% correct assignments. For spatial variation, DA identified Secchi disc depth and ammonia nitrogen as the significant discriminating parameters, with 81.6% correct assignments. Principal component analysis (PCA identified organic pollution, nutrient pollution, domestic sewage, and agricultural and surface runoff as the primary pollution sources, explaining 84.58%, 81.61% and 78.68% of the total variance in Groups A, B and C, respectively. These results demonstrate the effectiveness of integrated use of CA, DA and PCA for reservoir water quality evaluation and could assist managers in improving water resources management.

  19. Space charge studies in the PS

    CERN Document Server

    Asvesta, F; Damerau, H; Huschauer, A; Papaphilippou, Y; Serluca, M; Sterbini, G; Zisopoulos, P

    2017-01-01

    In this paper the results of Machine Development (MD)studies conducted at the CERN Proton Sychrotron (PS) arepresented. The main focus was the investigation of newworking points in an effort to characterize and potentiallyimprove the brightness for LHC-type beams in view of theLHC Injectors Upgrade (LIU). Various working points werecompared in terms of losses and emittance evolution. Sincespace charge and the resonances it excites are the main causefor emittance blow-up and losses, tunes close to excitedresonances were carefully studied. Mitigation techniques,such as bunch flattening using a double harmonic RF system,were also tested.

  20. Multivariate statistical techniques for the evaluation of surface water quality of the Himalayan foothills streams, Pakistan

    Science.gov (United States)

    Malik, Riffat Naseem; Hashmi, Muhammad Zaffar

    2017-10-01

    Himalayan foothills streams, Pakistan play an important role in living water supply and irrigation of farmlands; thus, the water quality is closely related to public health. Multivariate techniques were applied to check spatial and seasonal trends, and metals contamination sources of the Himalayan foothills streams, Pakistan. Grab surface water samples were collected from different sites (5-15 cm water depth) in pre-washed polyethylene containers. Fast Sequential Atomic Absorption Spectrophotometer (Varian FSAA-240) was used to measure the metals concentration. Concentrations of Ni, Cu, and Mn were high in pre-monsoon season than the post-monsoon season. Cluster analysis identified impaired, moderately impaired and least impaired clusters based on water parameters. Discriminant function analysis indicated spatial variability in water was due to temperature, electrical conductivity, nitrates, iron and lead whereas seasonal variations were correlated with 16 physicochemical parameters. Factor analysis identified municipal and poultry waste, automobile activities, surface runoff, and soil weathering as major sources of contamination. Levels of Mn, Cr, Fe, Pb, Cd, Zn and alkalinity were above the WHO and USEPA standards for surface water. The results of present study will help to higher authorities for the management of the Himalayan foothills streams.

  1. Denoised ordered subset statistically penalized algebraic reconstruction technique (DOS-SPART) in digital breast tomosynthesis

    Science.gov (United States)

    Garrett, John; Li, Yinsheng; Li, Ke; Chen, Guang-Hong

    2017-03-01

    Digital breast tomosynthesis (DBT) is a three dimensional (3D) breast imaging modality in which projections are acquired over a limited angular span around the compressed breast and reconstructed into image slices parallel to the detector. DBT has been shown to help alleviate the breast tissue overlapping issues of two dimensional (2D) mammography. Since the overlapping tissues may simulate cancer masses or obscure true cancers, this improvement is critically important for improved breast cancer screening and diagnosis. In this work, a model-based image reconstruction method is presented to show that spatial resolution in DBT volumes can be maintained while dose is reduced using the presented method when compared to that of a state-of-the-art commercial reconstruction technique. Spatial resolution was measured in phantom images and subjectively in a clinical dataset. Noise characteristics were explored in a cadaver study. In both the quantitative and subjective results the image sharpness was maintained and overall image quality was maintained at reduced doses when the model-based iterative reconstruction was used to reconstruct the volumes.

  2. The PS locomotive runs again

    CERN Multimedia

    2001-01-01

    Over forty years ago, the PS train entered service to steer the magnets of the accelerator into place... ... a service that was resumed last Tuesday. Left to right: Raymond Brown (CERN), Claude Tholomier (D.B.S.), Marcel Genolin (CERN), Gérard Saumade (D.B.S.), Ingo Ruehl (CERN), Olivier Carlier (D.B.S.), Patrick Poisot (D.B.S.), Christian Recour (D.B.S.). It is more than ten years since people at CERN heard the rumbling of the old PS train's steel wheels. Last Tuesday, the locomotive came back into service to be tested. It is nothing like the monstrous steel engines still running on conventional railways -just a small electric battery-driven vehicle employed on installing the magnets for the PS accelerator more than 40 years ago. To do so, it used the tracks that run round the accelerator. In fact, it is the grandfather of the LEP monorail. After PS was commissioned in 1959, the little train was used more and more rarely. This is because magnets never break down, or hardly ever! In fact, the loc...

  3. The PS Booster hits 40

    CERN Multimedia

    Joannah Caborn Wengler

    2012-01-01

    Many accelerators’ "round" birthdays are being celebrated at CERN these days – the PS turned 50 in 2009, the SPS was 35 in 2011, and this year it's the turn of the PS Booster to mark its 40th anniversary. Originally designed to accelerate 1013 protons to 800 MeV, it has far exceeded its initial design performance over the years.   The PS Booster in the 1970s. Imagine the scene: a group of accelerator physicists staring expectantly at a monitor, when suddenly a shout of joy goes up as a signal flickers across the screen. Does that sound familiar? Well, turn the clock back 40 years (longer hair, wider trouser legs) and you have the situation at the PS Booster on 26 May 1972. On that day, beam was injected into the Booster for the first time. “It was a real buzz,” says Heribert Koziol, then Chairman of the Running-in Committee. “We were very happy – and also a little relieved – when the beam finally...

  4. A two step linear statistical technique using leaps and bounds procedure for retrieval of geophysical parameters from microwave radiometric data

    Science.gov (United States)

    Kakar, R. K.; Pandey, P. C.

    1983-01-01

    A linear statistical technique using a 'leaps and bounds' procedure (Furnival and Wilson, 1974) is developed for retrieving geophysical parameters from remote measurements. It is used for retrieving sea surface temperatures from the Scaning Multichannel Microwave Radiometer (SMMR) on Seasat. The technique uses an efficient algorithm to select the best fixed-size subset of the 10 SMMR channels for linearly retrieving a given geophysical parameter. The 5-channel subset (6.6V, 6.6H 10H, 18V, 21H), where V and H refer to, respectively, the vertical and horizontal polarizations and the numbers are the channel frequencies in gigahertz, gives the minimum rms error in estimating the sea surface temperature. A comparison with ground truth indicates that the algorithm infers the temperature with an rms accuracy of better than 1.5 K under most environmental conditions. A quality control procedure which is seen as holding promise for further improving the accuracy is proposed.

  5. [Induced pluripotent stem (iPS) cell - issues for clinical application - ].

    Science.gov (United States)

    Aoi, Takashi

    2013-01-01

    Induced pluripotent stem (iPS) cells are generated from somatic cells by introducing small sets of transcription factors. iPS cells demonstrate pluripotency and the ability to self-renew. In addition, iPS cells can be generated from donor individuals with particular characteristics. Based on these features, iPS cells are expected to be applicable in drug discovery, the study of disease mechanisms and cell therapy. From a technical point of view, "diversity" is the key word. At present, iPS cells can be derived using various techniques, resulting in diversity in the quality of iPS cells generated. Therefore, optimization of the derivation technology is one of the most important issues. Another "diversity" is in the propensities amongst iPS cell lines derived using similar techniques. Thus, strategies for selecting good quality lines remain to be established. Considering such technical hurdles, establishment of an iPS cell bank consisting of high quality and versatile iPS lines is a promising idea because of the merits of cost and quality control. Now, we are exploring relevant parameters for the quality control of banked cells. The challenges facing clinical application of iPS cells are new but not unprecedented. To realize clinical applications of iPS cells, we need to make these challenges clear and overcome them through partnership not only with industry, governments and universities, but also patients and society at large.

  6. Statistical signal processing techniques for coherent transversal beam dynamics in synchrotrons

    Energy Technology Data Exchange (ETDEWEB)

    Alhumaidi, Mouhammad

    2015-03-04

    identifying and analyzing the betatron oscillation sourced from the kick based on its mixing and temporal patterns. The accelerator magnets can generate unwanted spurious linear and non-linear fields due to fabrication errors or aging. These error fields in the magnets can excite undesired resonances leading together with the space charge tune spread to long term beam losses and reducing dynamic aperture. Therefore, the knowledge of the linear and non-linear magnets errors in circular accelerator optics is very crucial for controlling and compensating resonances and their consequent beam losses and beam quality deterioration. This is indispensable, especially for high beam intensity machines. Fortunately, the relationship between the beam offset oscillation signals recorded at the BPMs is a manifestation of the accelerator optics, and can therefore be exploited in the determination of the optics linear and non-linear components. Thus, beam transversal oscillations can be excited deliberately for purposes of diagnostics operation of particle accelerators. In this thesis, we propose a novel method for detecting and estimating the optics lattice non-linear components located in-between the locations of two BPMs by analyzing the beam offset oscillation signals of a BPMs-triple containing these two BPMs. Depending on the non-linear components in-between the locations of the BPMs-triple, the relationship between the beam offsets follows a multivariate polynomial accordingly. After calculating the covariance matrix of the polynomial terms, the Generalized Total Least Squares method is used to find the model parameters, and thus the non-linear components. A bootstrap technique is used to detect the existing polynomial model orders by means of multiple hypothesis testing, and determine confidence intervals for the model parameters.

  7. Profiling the microRNA Expression in Human iPS and iPS-derived Retinal Pigment Epithelium.

    Science.gov (United States)

    Wang, Heuy-Ching; Greene, Whitney A; Kaini, Ramesh R; Shen-Gunther, Jane; Chen, Hung-I H; Cai, Hong; Wang, Yufeng

    2014-01-01

    The purpose of this study is to characterize the microRNA (miRNA) expression profiles of induced pluripotent stem (iPS) cells and retinal pigment epithelium (RPE) derived from induced pluripotent stem cells (iPS-RPE). MiRNAs have been demonstrated to play critical roles in both maintaining pluripotency and facilitating differentiation. Gene expression networks accountable for maintenance and induction of pluripotency are linked and share components with those networks implicated in oncogenesis. Therefore, we hypothesize that miRNA expression profiling will distinguish iPS cells from their iPS-RPE progeny. To identify and analyze differentially expressed miRNAs, RPE was derived from iPS using a spontaneous differentiation method. MiRNA microarray analysis identified 155 probes that were statistically differentially expressed between iPS and iPS-RPE cells. Up-regulated miRNAs including miR-181c and miR-129-5p may play a role in promoting differentiation, while down-regulated miRNAs such as miR-367, miR-18b, and miR-20b are implicated in cell proliferation. Subsequent miRNA-target and network analysis revealed that these miRNAs are involved in cellular development, cell cycle progression, cell death, and survival. A systematic interrogation of temporal and spatial expression of iPS-RPE miRNAs and their associated target mRNAs will provide new insights into the molecular mechanisms of carcinogenesis, eye differentiation and development.

  8. Model-based iterative reconstruction technique for radiation dose reduction in chest CT: comparison with the adaptive statistical iterative reconstruction technique.

    Science.gov (United States)

    Katsura, Masaki; Matsuda, Izuru; Akahane, Masaaki; Sato, Jiro; Akai, Hiroyuki; Yasaka, Koichiro; Kunimatsu, Akira; Ohtomo, Kuni

    2012-08-01

    To prospectively evaluate dose reduction and image quality characteristics of chest CT reconstructed with model-based iterative reconstruction (MBIR) compared with adaptive statistical iterative reconstruction (ASIR). One hundred patients underwent reference-dose and low-dose unenhanced chest CT with 64-row multidetector CT. Images were reconstructed with 50 % ASIR-filtered back projection blending (ASIR50) for reference-dose CT, and with ASIR50 and MBIR for low-dose CT. Two radiologists assessed the images in a blinded manner for subjective image noise, artefacts and diagnostic acceptability. Objective image noise was measured in the lung parenchyma. Data were analysed using the sign test and pair-wise Student's t-test. Compared with reference-dose CT, there was a 79.0 % decrease in dose-length product with low-dose CT. Low-dose MBIR images had significantly lower objective image noise (16.93 ± 3.00) than low-dose ASIR (49.24 ± 9.11, P ASIR images (24.93 ± 4.65, P ASIR for providing diagnostically acceptable low-dose CT images without severely compromising image quality. • Model-based iterative reconstruction (MBIR) creates high-quality low-dose CT images. • MBIR significantly improves image noise and artefacts over adaptive statistical iterative techniques. • MBIR shows greater potential than ASIR for diagnostically acceptable low-dose CT. • The prolonged processing time of MBIR may currently limit its routine use in clinical practice.

  9. Geographical provenancing of purple grape juices from different farming systems by proton transfer reaction mass spectrometry using supervised statistical techniques.

    Science.gov (United States)

    Granato, Daniel; Koot, Alex; van Ruth, Saskia M

    2015-10-01

    Organic, biodynamic and conventional purple grape juices (PGJ; n = 79) produced in Brazil and Europe were characterized by volatile organic compounds (m/z 20-160) measured by proton transfer reaction mass spectrometry (PTR-MS), and classification models were built using supervised statistical techniques. k-Nearest neighbours and soft independent modelling of class analogy (SIMCA) models discriminated adequately the Brazilian from European PGJ (overall efficiency of 81% and 87%, respectively). Partial least squares discriminant analysis (PLSDA) classified 100% European and 96% Brazilian PGJ. Similarly, when samples were grouped as either conventional or organic/biodynamic, the PLSDA model classified 81% conventional and 83% organic/biodynamic juices. Intraregional PLSDA models (juices produced in the same region - either Europe or Brazil) were developed and were deemed accurate in discriminating Brazilian organic from conventional PGJ (81% efficiency), as well as European conventional from organic/biodynamic PGJ (94% efficiency). PGJ from Brazil and Europe, as well as conventional and organic/biodynamic PGJ, were distinguished with high efficiency, but no statistical model was able to differentiate organic and biodynamic grape juices. These data support the hypothesis that no clear distinction between organic and biodynamic grape juices can be made with respect to volatile organic compounds. © 2014 Society of Chemical Industry.

  10. MicroRNA expression profiles of human iPS cells, retinal pigment epithelium derived from iPS, and fetal retinal pigment epithelium.

    Science.gov (United States)

    Greene, Whitney A; Muñiz, Alberto; Plamper, Mark L; Kaini, Ramesh R; Wang, Heuy-Ching

    2014-06-24

    The objective of this report is to describe the protocols for comparing the microRNA (miRNA) profiles of human induced-pluripotent stem (iPS) cells, retinal pigment epithelium (RPE) derived from human iPS cells (iPS-RPE), and fetal RPE. The protocols include collection of RNA for analysis by microarray, and the analysis of microarray data to identify miRNAs that are differentially expressed among three cell types. The methods for culture of iPS cells and fetal RPE are explained. The protocol used for differentiation of RPE from human iPS is also described. The RNA extraction technique we describe was selected to allow maximal recovery of very small RNA for use in a miRNA microarray. Finally, cellular pathway and network analysis of microarray data is explained. These techniques will facilitate the comparison of the miRNA profiles of three different cell types.

  11. Effects of the embedding kinetics on the surface nano-morphology of nano-grained Au and Ag films on PS and PMMA layers annealed above the glass transition temperature

    Science.gov (United States)

    Ruffino, F.; Torrisi, V.; Marletta, G.; Grimaldi, M. G.

    2012-06-01

    The morphology evolution of nano-grained Ag and Au films deposited on polystyrene (PS) and poly(methyl methacrylate) (PMMA) polymeric layers were studied, using the atomic force microscopy technique, when annealed above the polymers glass transition temperature. The main effects on the morphology changes were identified with those concerning the embedding kinetics of the Ag and Au nanoparticles in the PS or PMMA layers. The embedding process of the nanoparticles follows as a consequence of the long-range mobility of the polymeric chains above the glass transition temperature. In particular, the dependence of the nanoparticles mean height and surface density on the annealing time at various temperatures was quantified. The analyses of these behaviors allowed us: (1) to distinguish the overall embedding process in a first stage in which a thin wetting layer of the polymer coats the nanoparticles followed by a true embedding process of the nanoparticles into the polymer layer; (2) to evaluate the characteristic coating time for the Ag and Au nanoparticles in the PS and PMMA in the first stage; (3) to evaluate the characteristic embedding velocity for the Ag and Au nanoparticles in the PS and PMMA in the second stage; (4) to derive the activation energies for the embedding process of the Ag and Au nanoparticles in PS and PMMA; (5) to identify the embedding statistics of the Ag and Au nanoparticles in PS and PMMA with a "failure" Weibull statistics.

  12. A statistical approach for site error correction in lightning location networks with DF/TOA technique and its application results

    Science.gov (United States)

    Lu, Tao; Chen, Mingli; Du, Yaping; Qiu, Zongxu

    2017-02-01

    Lightning location network (LLN) with DF/TOA (direction-finder/time-of-arrival) combined technique has been widely used in the world. However, the accuracy of the lightning data from such LLNs has still been restricted by "site error", especially for those detected only by two DF/TOA sensors. In this paper we practice a statistical approach for evaluation and correction of "site error" for DF/TOA type LLN based on its lightning data. By comparing lightning locations recorded by at least 4 sensors between DF and TOA techniques, the spatial characteristics of "site error" for each sensor in the network can be obtained. The obtained "site error" then can be used to improve the accuracy of lightning locations especially those recorded by only 2 sensors. With this approach, the "site error" patterns for 23 sensors in Yunnan LLN are obtained. The features of these site error patterns are in good consistency with those in literature. Significant differences in lightning locations before and after "site error" corrections indicate that the proposed approach works effectively.

  13. Identification and comparison of electrical tapes using instrumental and statistical techniques: I. Microscopic surface texture and elemental composition.

    Science.gov (United States)

    Goodpaster, John V; Sturdevant, Amanda B; Andrews, Kristen L; Brun-Conti, Leanora

    2007-05-01

    Comparisons of polyvinyl chloride electrical tape typically rely upon evaluating class characteristics such as physical dimensions, surface texture, and chemical composition. Given the various techniques that are available for this purpose, a comprehensive study has been undertaken to establish an optimal analytical scheme for electrical tape comparisons. Of equal importance is the development of a quantitative means for sample discrimination. In this study, 67 rolls of black electrical tape representing 34 different nominal brands were analyzed via scanning electron microscopy and energy dispersive spectroscopy. Differences in surface roughness, calendering marks, and filler particle size were readily apparent, including between some rolls of the same nominal brand. The relative amounts of magnesium, aluminum, silicon, sulfur, lead, chlorine, antimony, calcium, titanium, and zinc varied greatly between brands and, in some cases, could be linked to the year of manufacture. For the first time, quantitative differentiation of electrical tapes was achieved through multivariate statistical techniques, with 36 classes identified within the sample population. A single-blind study was also completed where questioned tape samples were correctly associated with known exemplars. Finally, two case studies are presented where tape recovered from an improvised explosive device is compared with tape recovered from a suspect.

  14. The problem of sexual imbalance and techniques of the self in the Diagnostic and Statistical Manual of Mental Disorders.

    Science.gov (United States)

    Flore, Jacinthe

    2016-09-01

    This article examines the problematization of sexual appetite and its imbalances in the development of the Diagnostic and Statistical Manual of Mental Disorders (DSM) in the twentieth and twenty-first centuries. The dominant strands of historiographies of sexuality have focused on historicizing sexual object choice and understanding the emergence of sexual identities. This article emphasizes the need to contextualize these histories within a broader frame of historical interest in the problematization of sexual appetite. The first part highlights how sexual object choice, as a paradigm of sexual dysfunctions, progressively receded from medical interest in the twentieth century as the clinical gaze turned to the problem of sexual appetite and its imbalances. The second part uses the example of the newly introduced Female Sexual Interest/Arousal Disorder in the DSM-5 to explore how the Manual functions as a technique for taking care of the self. I argue that the design of the Manual and associated inventories and questionnaires paved the way for their interpretation and application as techniques for self-examination. © The Author(s) 2016.

  15. iPS-Cinderella Story in Cell Biology

    Directory of Open Access Journals (Sweden)

    Editorial

    2010-01-01

    Full Text Available As we step through the frontiers of modern Science, we are all witnesses to the Cinderella story repeating itself in the form of the iPS. The process of re-programming adult somatic cells to derive Induced Pluripotent stem cells (iPS with the wand of transcription factors and then differentiating them back to adult somatic cells resembles the transformation of Cinderella from a Cinder girl to princess and back to a Cinder girl after the ball; but the iPS-Cinderella is the most fascinating thing ever in cell biology!From the day iPS first made its headlines when it was first produced by Shinya Yamanaka at Kyoto University in Japan, Stem Cell scientists all over the world are re- doing their experiments so far done using other sources like embryonic and adult Stem cells with the iPS cells exploring their potential to the fullest. A Stem Cell science news page without this magic word of iPS is difficult to imagine these days and Scientists have been successful in growing most of the adult Cell types from iPS cells.iPS cells was the key to solve the problems of Immune rejection and Immunosupression required when using other allogeneic Stem cell types which had baffled scientists previously. But the issues raised by scientists about the use of viruses and Oncogenes in producing iPS cells were made groundless when scientists in February 2008 published the discovery of a technique that could remove oncogenes after the induction of pluripotency and now it is possible to induce pluripotency using plasmid transfection, piggyback transposon system and piggyback transposon system combined with a non viral vector system. The word of the day is pIPS which are protein-induced Pluripotent stem cells which are iPS cells that were generated without any genetic alteration of the adult cell. This research by the group of Sheng Ding in La Jolla, California made public in April 2009 showed that the generation of poly-arginine anchors was sufficient to induce

  16. EDH 'Millionaire' in PS Division

    CERN Document Server

    2001-01-01

    Christmas cheer! Left to right: Gerard Lobeau receives a bottle of Champagne from Derek Mathieson and Jurgen De Jonghe in recognition of EDH's millionth document. At 14:33 on Monday 3 December a technician in PS division, Gerard Lobeau, unwittingly became part of an important event in the life of CERN's Electronic Document Handling system (EDH). While ordering some pieces of aluminum for one of the PS's 10Mhz RF cavities, he created EDH document number 1,000,000. To celebrate the event Derek Mathieson (EDH Project Leader) and Jurgen De Jonghe (Original EDH Project Leader) presented Mr Lobeau with a bottle of champagne. As with 93% of material requests, Mr Lobeau's order was delivered within 24 hours. 'I usually never win anything' said Mr Lobeau as he accepted his prize, 'I initially though there may have been a problem with EDH when the document number had so many zeros in it, and was then surprised to get a phone call from you a few minutes later.' The EDH team had been monitoring the EDH document number ...

  17. Assessment of Water Quality in a Subtropical Alpine Lake Using Multivariate Statistical Techniques and Geostatistical Mapping: A Case Study

    Directory of Open Access Journals (Sweden)

    Chung-En Chung

    2011-04-01

    Full Text Available Concerns about the water quality in Yuan-Yang Lake (YYL, a shallow, subtropical alpine lake located in north-central Taiwan, has been rapidly increasing recently due to the natural and anthropogenic pollution. In order to understand the underlying physical and chemical processes as well as their associated spatial distribution in YYL, this study analyzes fourteen physico-chemical water quality parameters recorded at the eight sampling stations during 2008–2010 by using multivariate statistical techniques and a geostatistical method. Hierarchical clustering analysis (CA is first applied to distinguish the three general water quality patterns among the stations, followed by the use of principle component analysis (PCA and factor analysis (FA to extract and recognize the major underlying factors contributing to the variations among the water quality measures. The spatial distribution of the identified major contributing factors is obtained by using a kriging method. Results show that four principal components i.e., nitrogen nutrients, meteorological factor, turbidity and nitrate factors, account for 65.52% of the total variance among the water quality parameters. The spatial distribution of principal components further confirms that nitrogen sources constitute an important pollutant contribution in the YYL.

  18. Effects of hypoxia on pluripotency in murine iPS cells.

    Science.gov (United States)

    Sugimoto, Kouji; Yoshizawa, Yuu; Yamada, Shizuka; Igawa, Kazunari; Hayashi, Yoshihiko; Ishizaki, Hidetaka

    2013-10-01

    Retroviral transduction of four transcription factors (Oct4, Sox2, Klf4 and c-Myc) or three factors, excluding c-Myc, has been shown to initiate a reprogramming process that results in the transformation of murine fibroblasts to induced pluripotent stem (iPS) cells, and there has been a rapid increase in the number of iPS cell-based preclinical trials. In this study, the effects of these transcription factors were evaluated regarding the growth and differentiation of murine iPS cells under hypoxia. Based on the results of RT-PCR and alizarin red S staining, there were no statistical differences in the growth and differentiation of iPS cells or the induction of iPS cells to osteoblasts under hypoxia between the transcription factor groups. Furthermore, the function of hypoxia inducible factors (HIFs) in murine iPS cells under hypoxia was investigated in relation to the morphology and expression of transcription factors using RT-PCR and Western blotting. The HIF-2α knockdown group exhibited a decrease in the colony size of the iPS cells. The HIF-2α or -3α knockdown group demonstrated a statistically significant decrease in the transcription factor expression compared to that observed in the control group. These results demonstrate that HIF-2α among HIFs is the most influential candidate for the maintenance of the pluripotency of murine iPS cells. Copyright © 2013 Wiley Periodicals, Inc.

  19. Microfabricated device for co-culture of sympathetic neuron and iPS-derived cardiomyocytes.

    Science.gov (United States)

    Takeuchi, Akimasa; Shimba, Kenta; Takayama, Yuzo; Kotani, Kiyoshi; Lee, Jong-Kook; Noshiro, Makoto; Jimbo, Yasuhiko

    2013-01-01

    Induced pluripotent stem (iPS) cell-derived cardiomyocytes (iPS-CMs) has been expected as a cell source for therapy of serious heart failure. However, it is unclear whether the function of iPS-CMs is modulated by the host sympathetic nervous system. Here we developed a device for co-culture of sympathetic neurons and iPS-CMs using microfabrication technique. The device consisted of a culture chamber and a microelectrode-array (MEA) substrate. The superior cervical ganglion (SCG) neurons were co-cultured with iPS-CMs in a microfabricated device, which had multiple compartments. Several days after seeding, synapses were formed between SCG neurons and iPS-CMs, as confirmed by immunostaining. Spontaneous electrical activities of the SCG neurons and the iPS-CMs were observed from the electrode of the MEA substrate. The beat rate of iPS-CMs increased after electrical stimulation of the co-cultured SCG neurons. Such changes in the beat rate were prevented in the presence of propranolol, a β-adrenoreceptor antagonist. These results suggest that the microfabricated device will be utilized for studying the functional modulation of iPS-CMs by connected sympathetic neurons.

  20. Velocity-independent layer stripping of PP and PS reflection traveltimes

    Digital Repository Service at National Institute of Oceanography (India)

    Dewangan, P.; Tsvankin, I.

    Building accurate interval velocity models is critically important for seismic imaging and AVO (amplitude variation with offset) analysis. Here, we adapt the PP + PS = SS method to develop an exact technique for constructing the interval traveltime...

  1. Sonication-assisted synthesis of polystyrene (PS)/organoclay nanocomposites: influence of clay content

    Science.gov (United States)

    Suresh, Kelothu; Kumar, R. Vinoth; Kumar, Manish; Jeyapriya, M.; Anbarasan, R.; Pugazhenthi, G.

    2017-06-01

    This article presents the synthesis of a series of polystyrene (PS)/organoclay nanocomposite films consisting of different contents of clay (1-7 wt%) by sonication-coupled solvent-blending technique. The prepared PS nanocomposite films were characterized using various techniques, including X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), and thermal gravimetric analysis (TGA). The XRD and TEM results revealed the formation of exfoliated nanocomposites at lower loading of organoclay (<5 wt%). The presence of various functional groups in the organoclay and PS/organoclay nanocomposite was verified by FTIR spectra. The thermal stability of PS nanocomposites was significantly improved as compared to pristine PS, which is evident from TGA analysis. When 10% mass loss was chosen as a point of reference, the thermal degradation temperature of PS nanocomposite holding 7 wt% of organoclay was found to be 30 °C more over pristine PS. The thermal kinetic parameters such as activation energy ( E a), pre-exponential factor ( A), and the order of reaction ( n) were determined by employing the Coats-Redfern model. Thermal degradation reaction mechanism of PS nanocomposites was also investigated.

  2. Ps-atom scattering at low energies

    CERN Document Server

    Fabrikant, I I

    2015-01-01

    A pseudopotential for positronium-atom interaction, based on electron-atom and positron-atom phase shifts, is constructed, and the phase shifts for Ps-Kr and Ps-Ar scattering are calculated. This approach allows us to extend the Ps-atom cross sections, obtained previously in the impulse approximation [Phys. Rev. Lett. 112, 243201 (2014)], to energies below the Ps ionization threshold. Although experimental data are not available in this low-energy region, our results describe well the tendency of the measured cross sections to drop with decreasing velocity at $v<1$ a.u. Our results show that the effect of the Ps-atom van der Waals interaction is weak compared to the polarization interaction in electron-atom and positron-atom scattering. As a result, the Ps scattering length for both Ar and Kr is positive, and the Ramsauer-Townsend minimum is not observed for Ps scattering from these targets. This makes Ps scattering quite different from electron scattering in the low-energy region, in contrast to the inter...

  3. Enhanced personal protection at the PS

    CERN Multimedia

    Samuel Morier Genoud

    2013-01-01

    Pictures 03, 06, 07 08 : Pierre Ninin, deputy group leader of GS-ASE and responsible for the installation of the new PS complex safety system, in front of a new access control system.Pictures 10, 12 ,13 : View of Building 271, the future control centre of the new PS complex safety system.

  4. PS, SL and LHC Auditoria change names

    CERN Document Server

    2003-01-01

    Following the replacement of the PS, SL and LHC Divisions by the AB and AT Divisions, the Auditoria are also changing their names. PS Auditorium is renamed AB Meyrin SL Auditorium is renamed AB Prévessin LHC Auditorium is renamed AT

  5. Groundwater quality assessment of the shallow aquifers west of the Nile Delta (Egypt) using multivariate statistical and geostatistical techniques

    Science.gov (United States)

    Masoud, Alaa A.

    2014-07-01

    Extensive urban, agricultural and industrial expansions on the western fringe of the Nile Delta of Egypt have exerted much load on the water needs and lead to groundwater quality deterioration. Documenting the spatial variation of the groundwater quality and their controlling factors is vital to ensure sustainable water management and safe use. A comprehensive dataset of 451 shallow groundwater samples were collected in 2011 and 2012. On-site field measurements of the total dissolved solids (TDS), electric conductivity (EC), pH, temperature, as well as lab-based ionic composition of the major and trace components were performed. Groundwater types were derived and the suitability for irrigation use was evaluated. Multivariate statistical techniques of factor analysis and K-means clustering were integrated with the geostatistical semi-variogram modeling for evaluating the spatial hydrochemical variations and the driving factors as well as for hydrochemical pattern recognition. Most hydrochemical parameters showed very wide ranges; TDS (201-24,400 mg/l), pH (6.72-8.65), Na+ (28.30-7774 mg/l), and Cl- (7-12,186 mg/l) suggesting complex hydrochemical processes of multiple sources. TDS violated the limit (1200 mg/l) of the Egyptian standards for drinking water quality in many localities. Extreme concentrations of Fe2+, Mn2+, Zn2+, Cu2+, Ni2+, are mostly related to their natural content in the water-bearing sediments and/or to contamination from industrial leakage. Very high nitrate concentrations exceeding the permissible limit (50 mg/l) were potentially maximized toward hydrologic discharge zones and related to wastewater leakage. Three main water types; NaCl (29%), Na2SO4 (26%), and NaHCO3 (20%), formed 75% of the groundwater dominated in the saline depressions, sloping sides of the coastal ridges of the depressions, and in the cultivated/newly reclaimed lands intensely covered by irrigation canals, respectively. Water suitability for irrigation use clarified that the

  6. Seismic receiver function interpretation: Ps splitting or anisotropic underplating?

    Science.gov (United States)

    Liu, Zhen; Park, Jeffrey

    2017-03-01

    Crustal anisotropy is crucial to understanding the evolutionary history of Earth's lithosphere. Shear wave splitting of Moho P-to-S converted phases in receiver functions (RFs) have been often used to study crustal anisotropy. Harmonic variation of Moho Ps phases in delay times are used to infer splitting parameters of averaged anisotropy in the crust. However, crustal anisotropy may distribute at various levels within the crust due to complex deformational processes. Layered anisotropy requires careful investigation of the distribution of anisotropy before interpreting Moho Ps splitting. In this study, we show results from stations ARU in Russia, KIP in the Hawaiian Islands and LSA in Tibetan Plateau, where layered anisotropy is constrained well by intracrust Ps conversions at high frequencies using a harmonic-decomposition technique. Anisotropic velocity models are inferred by forward-modeling decomposed RF waveforms. We suggest that the harmonic variation of Moho Ps phases should always be investigated to check for anisotropic layering using RFs with frequency content above 1 Hz, rather than simply reporting averaged anisotropy of the whole crust.

  7. The HARP detector at the CERN PS

    CERN Document Server

    Catanesi, M G; Radicioni, E; Simone, S; Edgecock, R; Ellis, M; Robbins, S; Soler, F J P; Gößling, C; Mass, M; Bunyatov, S; Chukanov, A; Klimov, O; Krasin, I; Krasnoperov, A; Kustov, D; Popov, B; Serdiouk, V; Tereshchenko, V; Carassiti, V; Di Capua, E; Evangelisti, F; Vidal-Sitjes, G; Artamonov, A; Arce, P; Brocard, R; Decreuse, G; Friend, B; Giani, S; Gilardoni, S; Gorbunov, p; Grant, A; Grossheim, A; Gruber, P; Ivanchenko, V; Legrand, J C; Kayis-Topaksu,A; Panman, P; Papadopoulos, I; Pasternak, J; Chernyaev, E; Tsukerman, I; van der Vlugt, R; Veenhof, R; Wiebusch, C; Zucchelli, P; Blondel, A; Borghi, S; Campanelli, M; Cervera-Villanueva, A; Morone, M C; Prior, G; Schroeter, R; Kato, I; Gastaldi, Ugo; Mills, G B; Graulich, J S; Grégoire, G; Bonesini, M; Chignoli, F; Ferri, F; Paleari, F; Kirsanov, M; Postoev, V; Bagulya A; Grichine, V; Polukhina, N; Palladino, V; Coney, L; Schmitz, D; Barr, G; De Santo, A; Pattison, C; Zuber, K; Barichello, G; Bobisut, F; Gibin, D; Guglielmi, A; Laveder, M; Menegolli, A; Mezzetto M; Pepato, Adriano; Dumarchez, J; Troquereau, S; Vannucci, F; Dore, U; Iaciofano, A; Lobello, M; Marinilli, F; Orestano, D; Panayotov, D; Pasquali, M; Pastore, F; Tonazzo, A; Tortora, L; Booth, C; Buttar, C; Hodgson, P; Howlett, L; Nicholson, R; Bogomilovw, M; Burin, K; Chizhov, M; Kolev, D; Petev, P; Rusinov, I; Tsenov, R; Piperov, S; Temnikov, P; Apollonio, M; Chimenti, P; Giannini, G; Santin, G; Burguet-Castell, J; Gómez-Cadenas, J J; Novella, P; Sorel, M; Tornero, A

    2007-01-01

    HARP is a high-statistics, large solid angle experiment to measure hadron production using proton and pion beams with momenta between 1.5 and 15 GeV/c impinging on many different solid and liquid targets from low to high Z. The experiment, located in the T9 beam of the CERN PS, took data in 2001 and 2002. For the measurement of momenta of produced particles and for the identification of particle types, the experiment includes a large-angle spectrometer, based on a Time Projection Chamber and a system of Resistive Plate Chambers, and a forward spectrometer equipped with a set of large drift chambers, a threshold Cherenkov detector, a time-of-flight wall and an electromagnetic calorimeter. The large angle system uses a solenoidal magnet, while the forward spectrometer is based on a dipole magnet. Redundancy in particle identification has been sought, to enable the cross-calibration of efficiencies and to obtain a few percent overall accuracy in the cross-section measurements. Detector construction, operation an...

  8. The use of adaptive statistical iterative reconstruction (ASiR) technique in evaluation of patients with cervical spine trauma: impact on radiation dose reduction and image quality.

    Science.gov (United States)

    Patro, Satya N; Chakraborty, Santanu; Sheikh, Adnan

    2016-01-01

    The aim of this study was to evaluate the impact of adaptive statistical iterative reconstruction (ASiR) technique on the image quality and radiation dose reduction. The comparison was made with the traditional filtered back projection (FBP) technique. We retrospectively reviewed 78 patients, who underwent cervical spine CT for blunt cervical trauma between 1 June 2010 and 30 November 2010. 48 patients were imaged using traditional FBP technique and the remaining 30 patients were imaged using the ASiR technique. The patient demographics, radiation dose, objective image signal and noise were recorded; while subjective noise, sharpness, diagnostic acceptability and artefacts were graded by two radiologists blinded to the techniques. We found that the ASiR technique was able to reduce the volume CT dose index, dose-length product and effective dose by 36%, 36.5% and 36.5%, respectively, compared with the FBP technique. There was no significant difference in the image noise (p = 0.39), signal (p = 0.82) and signal-to-noise ratio (p = 0.56) between the groups. The subjective image quality was minimally better in the ASiR group but not statistically significant. There was excellent interobserver agreement on the subjective image quality and diagnostic acceptability for both groups. The use of ASiR technique allowed approximately 36% radiation dose reduction in the evaluation of cervical spine without degrading the image quality. The present study highlights that the ASiR technique is extremely helpful in reducing the patient radiation exposure while maintaining the image quality. It is highly recommended to utilize this novel technique in CT imaging of different body regions.

  9. Impact of the Adaptive Statistical Iterative Reconstruction Technique on Radiation Dose and Image Quality in Bone SPECT/CT.

    Science.gov (United States)

    Sibille, Louis; Chambert, Benjamin; Alonso, Sandrine; Barrau, Corinne; D'Estanque, Emmanuel; Al Tabaa, Yassine; Collombier, Laurent; Demattei, Christophe; Kotzki, Pierre-Olivier; Boudousq, Vincent

    2016-07-01

    The purpose of this study was to compare a routine bone SPECT/CT protocol using CT reconstructed with filtered backprojection (FBP) with an optimized protocol using low-dose CT images reconstructed with adaptive statistical iterative reconstruction (ASiR). In this prospective study, enrolled patients underwent bone SPECT/CT, with 1 SPECT acquisition followed by 2 randomized CT acquisitions: FBP CT (FBP; noise index, 25) and ASiR CT (70% ASiR; noise index, 40). The image quality of both attenuation-corrected SPECT and CT images was visually (5-point Likert scale, 2 interpreters) and quantitatively (contrast ratio [CR] and signal-to-noise ratio [SNR]) estimated. The CT dose index volume, dose-length product, and effective dose were compared. Seventy-five patients were enrolled in the study. Quantitative attenuation-corrected SPECT evaluation showed no inferiority for contrast ratio and SNR issued from FBP CT or ASiR CT (respectively, 13.41 ± 7.83 vs. 13.45 ± 7.99 and 2.33 ± 0.83 vs. 2.32 ± 0.84). Qualitative image analysis showed no difference between attenuation-corrected SPECT images issued from FBP CT or ASiR CT for both interpreters (respectively, 3.5 ± 0.6 vs. 3.5 ± 0.6 and 3.6 ± 0.5 vs. 3.6 ± 0.5). Quantitative CT evaluation showed no inferiority for SNR between FBP and ASiR CT images (respectively, 0.93 ± 0.16 and 1.07 ± 0.17). Qualitative image analysis showed no quality difference between FBP and ASiR CT images for both interpreters (respectively, 3.8 ± 0.5 vs. 3.6 ± 0.5 and 4.0 ± 0.1 vs. 4.0 ± 0.2). Mean CT dose index volume, dose-length product, and effective dose for ASiR CT (3.0 ± 2.0 mGy, 148 ± 85 mGy⋅cm, and 2.2 ± 1.3 mSv) were significantly lower than for FBP CT (8.5 ± 3.7 mGy, 365 ± 160 mGy⋅cm, and 5.5 ± 2.4 mSv). The use of 70% ASiR blending in bone SPECT/CT can reduce the CT radiation dose by 60%, with no sacrifice in attenuation-corrected SPECT and CT image quality, compared with the conventional protocol using FBP CT

  10. Updating the Psoriatic Arthritis (PsA) Core Domain Set: A Report from the PsA Workshop at OMERACT 2016.

    Science.gov (United States)

    Orbai, Ana-Maria; de Wit, Maarten; Mease, Philip J; Callis Duffin, Kristina; Elmamoun, Musaab; Tillett, William; Campbell, Willemina; FitzGerald, Oliver; Gladman, Dafna D; Goel, Niti; Gossec, Laure; Hoejgaard, Pil; Leung, Ying Ying; Lindsay, Chris; Strand, Vibeke; van der Heijde, Désirée M; Shea, Bev; Christensen, Robin; Coates, Laura; Eder, Lihi; McHugh, Neil; Kalyoncu, Umut; Steinkoenig, Ingrid; Ogdie, Alexis

    2017-10-01

    To include the patient perspective in accordance with the Outcome Measures in Rheumatology (OMERACT) Filter 2.0 in the updated Psoriatic Arthritis (PsA) Core Domain Set for randomized controlled trials (RCT) and longitudinal observational studies (LOS). At OMERACT 2016, research conducted to update the PsA Core Domain Set was presented and discussed in breakout groups. The updated PsA Core Domain Set was voted on and endorsed by OMERACT participants. We conducted a systematic literature review of domains measured in PsA RCT and LOS, and identified 24 domains. We conducted 24 focus groups with 130 patients from 7 countries representing 5 continents to identify patient domains. We achieved consensus through 2 rounds of separate surveys with 50 patients and 75 physicians, and a nominal group technique meeting with 12 patients and 12 physicians. We conducted a workshop and breakout groups at OMERACT 2016 in which findings were presented and discussed. The updated PsA Core Domain Set endorsed with 90% agreement by OMERACT 2016 participants included musculoskeletal disease activity, skin disease activity, fatigue, pain, patient's global assessment, physical function, health-related quality of life, and systemic inflammation, which were recommended for all RCT and LOS. These were important, but not required in all RCT and LOS: economic cost, emotional well-being, participation, and structural damage. Independence, sleep, stiffness, and treatment burden were on the research agenda. The updated PsA Core Domain Set was endorsed at OMERACT 2016. Next steps for the PsA working group include evaluation of PsA outcome measures and development of a PsA Core Outcome Measurement Set.

  11. Ps 22 in Gospels’ interpretation of Passion

    Directory of Open Access Journals (Sweden)

    Sylwester Jędrzejewski

    2012-09-01

    Full Text Available Ps 22 is a piece of artistically high poetry, clear images and metaphors, historical and prophetic references. The conviction of biblical scholars that the New Testament writers has recognized in Ps 22 prophetic witness of passion, accompanies the Church from its beginnings. The words of Jesus on the cross, taken from Ps 22: 2, have a character of lamentable re-symbolization of the prayer of Israel. These words establish a theological answer in the form of suitable credo as well. Dramatic question “why?” is connected with a proclamation and identification “My God”. The personal experience of oppression and death is included by Jesus in the history of his nation and in the experience of God. Ps 22 in the Gospels’ passion context becomes a proclamation form of prayer and a very personal, expressed in such dramatic circumstances confession of the faith.

  12. Yasp for LEIR to PS injection

    CERN Document Server

    Kain, V; Bartosik, H; Huschauer, A; Jacquet, D; Nicosia, D; Pasinelli, S; Wenninger, J

    2017-01-01

    The steering program YASP was introduced in the LEIRinjection as well as the extraction lines in 2016 to correctthe trajectories with well-known model based correctionalgorithms such as MICADO or SVD. In addition a YASPconfiguration was prepared to correct the extraction linetogether with the first turn of the PS. In this way the injectionoscillations can be corrected while keeping the trajectoryreasonable in the PS injection line.

  13. PS overcomes two serious magnet failures

    CERN Multimedia

    Maximilien Brice

    2003-01-01

    Two magnets and a bus bar connection in the PS were found to be faulty during high-voltage tests at the end of the accelerator shutdown. A five-week repair schedule was quickly devised. A team of mechanics, technicians and engineers worked at full speed to replace the faulty magnets, succeeding in limiting the delay of the accelerators' spring start-up to two weeks. Here we see the PS magnet string awaiting the replacement no. 6 magnet.

  14. Statistical methods

    CERN Document Server

    Szulc, Stefan

    1965-01-01

    Statistical Methods provides a discussion of the principles of the organization and technique of research, with emphasis on its application to the problems in social statistics. This book discusses branch statistics, which aims to develop practical ways of collecting and processing numerical data and to adapt general statistical methods to the objectives in a given field.Organized into five parts encompassing 22 chapters, this book begins with an overview of how to organize the collection of such information on individual units, primarily as accomplished by government agencies. This text then

  15. Data-driven nonlinear technique for condition monitoring

    Energy Technology Data Exchange (ETDEWEB)

    Hively, L.M.

    1997-04-01

    This paper describes a sensitive technique for distinguishing changes in a nonlinear process. The method obtains a phase-space (PS) representation of the process, which in turn is converted into a probability density function (PDF). Condition change is monitored by comparing two PS-PDFs via a {chi}{sup 2} statistical measure. One example application involves monitoring of brain waves to distinguish various states in an epileptic patient. A second example distinguishes different drilling conditions from spindle motor current data. A third example distinguishes balanced and unbalanced pumping conditions from power data.

  16. Statistical factor analysis technique for characterizing basalt through interpreting nuclear and electrical well logging data (case study from Southern Syria).

    Science.gov (United States)

    Asfahani, Jamal

    2014-02-01

    Factor analysis technique is proposed in this research for interpreting the combination of nuclear well logging, including natural gamma ray, density and neutron-porosity, and the electrical well logging of long and short normal, in order to characterize the large extended basaltic areas in southern Syria. Kodana well logging data are used for testing and applying the proposed technique. The four resulting score logs enable to establish the lithological score cross-section of the studied well. The established cross-section clearly shows the distribution and the identification of four kinds of basalt which are hard massive basalt, hard basalt, pyroclastic basalt and the alteration basalt products, clay. The factor analysis technique is successfully applied on the Kodana well logging data in southern Syria, and can be used efficiently when several wells and huge well logging data with high number of variables are required to be interpreted. © 2013 Elsevier Ltd. All rights reserved.

  17. Statistical Analyses of Scatterplots to Identify Important Factors in Large-Scale Simulations, 2. Robustness of Techniques

    Energy Technology Data Exchange (ETDEWEB)

    Helton, J.C.; Kleijnen, J.P.C.

    1999-03-24

    Procedures for identifying patterns in scatterplots generated in Monte Carlo sensitivity analyses are described and illustrated. These procedures attempt to detect increasingly complex patterns in scatterplots and involve the identification of (i) linear relationships with correlation coefficients, (ii) monotonic relationships with rank correlation coefficients, (iii) trends in central tendency as defined by means, medians and the Kruskal-Wallis statistic, (iv) trends in variability as defined by variances and interquartile ranges, and (v) deviations from randomness as defined by the chi-square statistic. A sequence of example analyses with a large model for two-phase fluid flow illustrates how the individual procedures can differ in the variables that they identify as having effects on particular model outcomes. The example analyses indicate that the use of a sequence of procedures is a good analysis strategy and provides some assurance that an important effect is not overlooked.

  18. Application of multivariate statistical projection techniques for monitoring a sequencing batch reactor (SBR); Aplicacion de tecnicas estadisticas de proyeccion multivariante para la monitorizacion de un SBR

    Energy Technology Data Exchange (ETDEWEB)

    Aguado Garcia, D.; Ferrer Riquelme, A. J.; Seco Torrecillas, A.; Ferrer Polo, J.

    2006-07-01

    Due to the increasingly stringent effluents quality requirements imposed by the regulations, monitoring wastewater treatment plants (WWTP) becomes extremely important in order to achieve efficient process operations. Nowadays, at modern WWTP large number of online process variables are collected and these variable are usually highly correlated. Therefore, appropriate techniques are required to extract the information from the huge amount of collected data. In this work, the application of multivariate statistical projection techniques is presented as an effective strategy for monitoring a sequencing batch reactor (SBR) operated for enhanced biological phosphorus removal. (Author)

  19. Comparison of image quality between filtered back-projection and the adaptive statistical and novel model-based iterative reconstruction techniques in abdominal CT for renal calculi

    OpenAIRE

    Vardhanabhuti, Varut; Ilyas, Sumaira; Gutteridge, Catherine; Freeman, Simon J.; Roobottom, Carl A

    2013-01-01

    Objectives To compare image quality on computed tomographic (CT) images acquired with filtered back-projection (FBP), adaptive statistical iterative reconstruction (ASIR) and model-based iterative reconstruction (MBIR) techniques in CT kidney/ureter/bladder (KUB) examination. Methods Eighteen patients underwent standard protocol CT KUB at our institution. The same raw data were reconstructed using FBP, ASIR and MBIR. Objective [mean image noise, contrast-to-noise ratio (CNR) for kidney and me...

  20. Low energy o-Ps-o-Ps elastic scattering using a simple model

    Energy Technology Data Exchange (ETDEWEB)

    Himanshu, Sharma [Veer Kunwar Singh Univ., Dept. of Physics, Bihar (India); Kiran, Kumari [R N College, P. G. Dept. of Physics, Bihar (India); Sumana, Chakraborty [Indian Association for the Cultivation of Science, Dept. of Theoretical Physics (India)

    2009-06-15

    A simple model is employed to investigate o-Ps-o-Ps (positronium-positronium) scattering at low energies. This model contains the effect of exchange explicitly and a model long range potential in the framework of static-exchange model. These two physical features are of key importance in Ps-Ps (atom-atom) scattering system. S-wave triplet-triplet and singlet-singlet scattering lengths and corresponding phase shifts up to the incident momentum k = 0.5 a.u. are in excellent agreement with those yielded by most elaborate and theoretically sound predictions. (authors)

  1. Elemental analysis of ancient potteries of Vellore Dist, Tamil Nadu, India by ED-XRF technique with statistical approach

    Directory of Open Access Journals (Sweden)

    A. Naseerutheen

    2014-03-01

    Full Text Available In the analysis of archaeological pottery, Energy Dispersive X-ray florescence analysis has been utilized to establish the elemental concentrations up to fourteen chemical elements for each of 14 archaeological pottery samples from Vellore Dist, Tamil Nadu, India. The EDXRF results have been processed using two multivariate statistical cluster and principal component analysis (PCA methods in order to determine the similarities and correlation between the selected samples based on their elemental composition. The methodology successfully separates the samples where two distinct chemical groups were discerned.

  2. Model-based iterative reconstruction technique for radiation dose reduction in chest CT: comparison with the adaptive statistical iterative reconstruction technique

    Energy Technology Data Exchange (ETDEWEB)

    Katsura, Masaki; Matsuda, Izuru; Akahane, Masaaki; Sato, Jiro; Akai, Hiroyuki; Yasaka, Koichiro; Kunimatsu, Akira; Ohtomo, Kuni [University of Tokyo, Department of Radiology, Graduate School of Medicine, Bunkyo-ku, Tokyo (Japan)

    2012-08-15

    To prospectively evaluate dose reduction and image quality characteristics of chest CT reconstructed with model-based iterative reconstruction (MBIR) compared with adaptive statistical iterative reconstruction (ASIR). One hundred patients underwent reference-dose and low-dose unenhanced chest CT with 64-row multidetector CT. Images were reconstructed with 50 % ASIR-filtered back projection blending (ASIR50) for reference-dose CT, and with ASIR50 and MBIR for low-dose CT. Two radiologists assessed the images in a blinded manner for subjective image noise, artefacts and diagnostic acceptability. Objective image noise was measured in the lung parenchyma. Data were analysed using the sign test and pair-wise Student's t-test. Compared with reference-dose CT, there was a 79.0 % decrease in dose-length product with low-dose CT. Low-dose MBIR images had significantly lower objective image noise (16.93 {+-} 3.00) than low-dose ASIR (49.24 {+-} 9.11, P < 0.01) and reference-dose ASIR images (24.93 {+-} 4.65, P < 0.01). Low-dose MBIR images were all diagnostically acceptable. Unique features of low-dose MBIR images included motion artefacts and pixellated blotchy appearances, which did not adversely affect diagnostic acceptability. Diagnostically acceptable chest CT images acquired with nearly 80 % less radiation can be obtained using MBIR. MBIR shows greater potential than ASIR for providing diagnostically acceptable low-dose CT images without severely compromising image quality. (orig.)

  3. LS1 Report: PS beams are back!

    CERN Multimedia

    Katarina Anthony & Anaïs Schaeffer

    2014-01-01

    For the first time in over 15 months, there are beams back in the PS. Making their first tour of the accelerator today, 20 June, their injection marks the end of weeks of cold checkouts and hardware commissioning in the PS.   The CERN Control Centre (CCC) is back in business: people gather to restart the LHC injectors, today the PS. Since hardware commissioning was wrapped up on 23 May, the Operations Group (BE-OP) has been conducting cold checkouts on the PS. This involves switching on all of the machine's systems, verifying that they respond to commands by OP and ensuring they are calibrated to beam timings. "These verifications were done, in part, during the hardware commissioning dry runs," says Rende Steerenberg, PS section leader. "But the cold checkouts are on a much larger scale, as we act as if there is beam in the whole machine. We placed a full load on the controls system, cooling, networks, etc. in order to setup the accelerator in the most realis...

  4. Security Classification Using Automated Learning (SCALE): Optimizing Statistical Natural Language Processing Techniques to Assign Security Labels to Unstructured Text

    Science.gov (United States)

    2010-12-01

    techniques de traitement du langage naturel statistique et d’apprentissage automa- tique pour attribuer automatiquement une classification de sécurité à...turel statistique (TLNS) et de l’apprentissage automatique au moment d’évaluer la sensibilité d’un texte non structuré. Nous avons effectué une...résultats démontrent que le traitement du langage naturel statistique combiné à l’apprentissage automatique est un moyen efficace qui permet

  5. Vital statistics

    CERN Document Server

    MacKenzie, Dana

    2004-01-01

    The drawbacks of using 19th-century mathematics in physics and astronomy are illustrated. To continue with the expansion of the knowledge about the cosmos, the scientists will have to come in terms with modern statistics. Some researchers have deliberately started importing techniques that are used in medical research. However, the physicists need to identify the brand of statistics that will be suitable for them, and make a choice between the Bayesian and the frequentists approach. (Edited abstract).

  6. PS overcomes two serious magnet failures

    CERN Multimedia

    Maximilien Brice

    2003-01-01

    Two magnets and a bus bar connection in the PS were found to be faulty during high-voltage tests at the end of the accelerator shutdown. A five-week repair schedule was quickly devised. A team of mechanics, technicians and engineers worked at full speed to replace the faulty magnets, succeeding in limiting the delay of the accelerators' spring start-up to two weeks. These pictures show one of the magnets (no. 19) on the PS locomotive brought back into service for the removal and replacement operations.

  7. Assessing the hydrogeochemical processes affecting groundwater pollution in arid areas using an integration of geochemical equilibrium and multivariate statistical techniques.

    Science.gov (United States)

    El Alfy, Mohamed; Lashin, Aref; Abdalla, Fathy; Al-Bassam, Abdulaziz

    2017-10-01

    Rapid economic expansion poses serious problems for groundwater resources in arid areas, which typically have high rates of groundwater depletion. In this study, integration of hydrochemical investigations involving chemical and statistical analyses are conducted to assess the factors controlling hydrochemistry and potential pollution in an arid region. Fifty-four groundwater samples were collected from the Dhurma aquifer in Saudi Arabia, and twenty-one physicochemical variables were examined for each sample. Spatial patterns of salinity and nitrate were mapped using fitted variograms. The nitrate spatial distribution shows that nitrate pollution is a persistent problem affecting a wide area of the aquifer. The hydrochemical investigations and cluster analysis reveal four significant clusters of groundwater zones. Five main factors were extracted, which explain >77% of the total data variance. These factors indicated that the chemical characteristics of the groundwater were influenced by rock-water interactions and anthropogenic factors. The identified clusters and factors were validated with hydrochemical investigations. The geogenic factors include the dissolution of various minerals (calcite, aragonite, gypsum, anhydrite, halite and fluorite) and ion exchange processes. The anthropogenic factors include the impact of irrigation return flows and the application of potassium, nitrate, and phosphate fertilizers. Over time, these anthropogenic factors will most likely contribute to further declines in groundwater quality. Copyright © 2017 Elsevier Ltd. All rights reserved.

  8. Beam Quality Preservation in the CERN PS-SPS Complex

    CERN Multimedia

    Arduini, Gianluigi

    2004-01-01

    The LHC will require beams of unprecedented transverse and longitudinal brightness. Their production imposes tight constraints on the emittance growth in each element of the LHC injector chain, namely the PS-SPS Accelerator Complex. The problems encountered at the different stages of the acceleration in the complex span a wide range of topics, such as injection matching, RF gymnastics, space charge, transverse and longitudinal single- and coupled-bunch instabilities, and electron cloud effects. The measurement techniques developed and applied to identify and study the various sources of emittance dilution to the high precision required for the LHC beams and the solutions found to control such phenomena are illustrated.

  9. Successful online learning – the five Ps

    Directory of Open Access Journals (Sweden)

    Jim FLOOD

    2004-04-01

    Full Text Available Successful online learning – the five Ps Jim FLOOD E-learning Consultant-UK jimflood@btinternet.com Key learning points • An important aspect of design for online learning is visual ergonomics. • Learning theories offer poor predictive power in terms of how learners work and learn. • Success at learning is closely related to emotional engagement–and learning designers tend to ignore this aspect. • Online learning poses a challenging experience for learners–and they need support to cope with it. • A key goal to achieve Praxis – being able to put learning into practice. Many of you will be familiar with the three (or more Ps of marketing and even if not, as trainers or teachers you are likely to have used mnemonics as an aid to retention and recall. Mnemonics are especially useful when you need to get the key points to ‘stick’ in the minds of your audience. With this in mind I offer you the 5 Ps of online learning: Presentation, Pedagogy, Promotion, Preparation and Props. What I offer is not new; in fact much of it results from the eleven years of online teaching and learning at The Open University, the £22 million it has spent on research and evaluation 1, and the worldwide community that have been sharing experience in recent years. You can therefore consider these 5 Ps to be a convenient re-packing of the information and experience that can be found in abundance on the Internet. Presentation Good graphic design appeals to the subtle process by which the brain processes information and, as a result, we decide if we like the ‘look and feel’ of a visual environment. Part of liking this ‘look and feel’ is the way the text and pictorial layout can appear inviting and encouraging–a vital aspect of any online learning environment. Another aspect of presentation is how the text reads in terms of engaging the learner and introducing the story to be told–as well as being written in clear and concise English When browsing through books

  10. A large-area ultra-precision 2D geometrical measurement technique based on statistical random phase detection

    Science.gov (United States)

    Ekberg, Peter; Stiblert, Lars; Mattsson, Lars

    2012-03-01

    The manufacturing of high-quality chrome masks used in the display industry for the manufacturing of liquid crystals, organic light emission diodes and other display devices would not be possible without high-precision large-area metrology. In contrast to the semiconductor industry where 6‧ masks are most common, the quartz glass masks for the manufacturing of large area TVs can have sizes of up to 1.6 × 1.8 m2. Besides the large area, there are demands of sub-micrometer accuracy in ‘registration’, i.e. absolute dimensional measurements and nanometer requirements for ‘overlay’, i.e. repeatability. The technique for making such precise measurements on large masks is one of the most challenging tasks in dimensional metrology today. This paper presents a new approach to two-dimensional (2D) ultra-precision measurements based on random sampling. The technique was recently presented for ultra-precise one-dimensional (1D) measurement. The 1D method relies on timing the scanning of a focused laser beam 200 µm in the Y-direction from an interferometrically determined reference position. This microsweep is controlled by an acousto-optical deflector. By letting the microsweep scan from random X-positions, we can build XY-recordings through a time-to-space conversion that gives very precise maps of the feature edges of the masks. The method differs a lot from ordinary image processing methods using CCD or CMOS sensors for capturing images in the spatial domain. We use events grabbed by a single detector in the time domain in both the X- and Y-directions. After a simple scaling, we get precise and repeatable spatial information. Thanks to the extremely linear microsweep and its precise power control, spatial and intensity distortions, common in ordinary image processing systems using 2D optics and 2D sensors, can be practically eliminated. Our 2D method has proved to give a standard deviation in repeatability of less than 4 nm (1σ) in both the X- and Y

  11. New scanning technique using Adaptive Statistical Iterative Reconstruction (ASIR) significantly reduced the radiation dose of cardiac CT.

    Science.gov (United States)

    Tumur, Odgerel; Soon, Kean; Brown, Fraser; Mykytowycz, Marcus

    2013-06-01

    The aims of our study were to evaluate the effect of application of Adaptive Statistical Iterative Reconstruction (ASIR) algorithm on the radiation dose of coronary computed tomography angiography (CCTA) and its effects on image quality of CCTA and to evaluate the effects of various patient and CT scanning factors on the radiation dose of CCTA. This was a retrospective study that included 347 consecutive patients who underwent CCTA at a tertiary university teaching hospital between 1 July 2009 and 20 September 2011. Analysis was performed comparing patient demographics, scan characteristics, radiation dose and image quality in two groups of patients in whom conventional Filtered Back Projection (FBP) or ASIR was used for image reconstruction. There were 238 patients in the FBP group and 109 patients in the ASIR group. There was no difference between the groups in the use of prospective gating, scan length or tube voltage. In ASIR group, significantly lower tube current was used compared with FBP group, 550 mA (450-600) vs. 650 mA (500-711.25) (median (interquartile range)), respectively, P ASIR group compared with FBP group, 4.29 mSv (2.84-6.02) vs. 5.84 mSv (3.88-8.39) (median (interquartile range)), respectively, P ASIR was associated with increased image noise compared with FBP (39.93 ± 10.22 vs. 37.63 ± 18.79 (mean ± standard deviation), respectively, P ASIR reduces the radiation dose of CCTA without affecting the image quality. © 2013 The Authors. Journal of Medical Imaging and Radiation Oncology © 2013 The Royal Australian and New Zealand College of Radiologists.

  12. Reducing abdominal CT radiation dose with the adaptive statistical iterative reconstruction technique in children: a feasibility study

    Energy Technology Data Exchange (ETDEWEB)

    Vorona, Gregory A. [The Children' s Hospital of Pittsburgh of UPMC, Department of Radiology, Pittsburgh, PA (United States); Allegheny General Hospital, Department of Radiology, Pittsburgh, PA (United States); Ceschin, Rafael C.; Clayton, Barbara L.; Sutcavage, Tom; Tadros, Sameh S.; Panigrahy, Ashok [The Children' s Hospital of Pittsburgh of UPMC, Department of Radiology, Pittsburgh, PA (United States)

    2011-09-15

    The use of the adaptive statistical iterative reconstruction (ASIR) algorithm has been shown to reduce radiation doses in adults undergoing abdominal CT studies while preserving image quality. To our knowledge, no studies have been done to validate the use of ASIR in children. To retrospectively evaluate differences in radiation dose and image quality in pediatric CT abdominal studies utilizing 40% ASIR compared with filtered-back projection (FBP). Eleven patients (mean age 8.5 years, range 2-17 years) had separate 40% ASIR and FBP enhanced abdominal CT studies on different days between July 2009 and October 2010. The ASIR studies utilized a 38% mA reduction in addition to our pediatric protocol mAs. Study volume CT dose indexes (CTDI{sub vol}) and dose-length products (DLP) were recorded. A consistent representative image was obtained from each study. The images were independently evaluated by two radiologists in a blinded manner for diagnostic utility, image sharpness and image noise. The average CTDI{sub vol} and DLP for the 40% ASIR studies were 4.25 mGy and 185.04 mGy-cm, compared with 6.75 mGy and 275.79 mGy-cm for the FBP studies, representing 37% and 33% reductions in both, respectively. The radiologists' assessments of subjective image quality did not demonstrate any significant differences between the ASIR and FBP images. In our experience, the use of 40% ASIR with a 38% decrease in mA lowers the radiation dose for children undergoing enhanced abdominal examinations by an average of 33%, while maintaining diagnostically acceptable images. (orig.)

  13. Statistical model to perform error analysis of curve fits of wind tunnel test data using the techniques of analysis of variance and regression analysis

    Science.gov (United States)

    Alston, D. W.

    1981-01-01

    The considered research had the objective to design a statistical model that could perform an error analysis of curve fits of wind tunnel test data using analysis of variance and regression analysis techniques. Four related subproblems were defined, and by solving each of these a solution to the general research problem was obtained. The capabilities of the evolved true statistical model are considered. The least squares fit is used to determine the nature of the force, moment, and pressure data. The order of the curve fit is increased in order to delete the quadratic effect in the residuals. The analysis of variance is used to determine the magnitude and effect of the error factor associated with the experimental data.

  14. MODEL APPLICATION MULTIVARIATE ANALYSIS OF STATISTICAL TECHNIQUES PCA AND HCA ASSESSMENT QUESTIONNAIRE ON CUSTOMER SATISFACTION: CASE STUDY IN A METALLURGICAL COMPANY OF METAL CONTAINERS

    Directory of Open Access Journals (Sweden)

    Cláudio Roberto Rosário

    2012-07-01

    Full Text Available The purpose of this research is to improve the practice on customer satisfaction analysis The article presents an analysis model to analyze the answers of a customer satisfaction evaluation in a systematic way with the aid of multivariate statistical techniques, specifically, exploratory analysis with PCA – Partial Components Analysis with HCA - Hierarchical Cluster Analysis. It was tried to evaluate the applicability of the model to be used by the issue company as a tool to assist itself on identifying the value chain perceived by the customer when applied the questionnaire of customer satisfaction. It was found with the assistance of multivariate statistical analysis that it was observed similar behavior among customers. It also allowed the company to conduct reviews on questions of the questionnaires, using analysis of the degree of correlation between the questions that was not a company’s practice before this research.

  15. Combined statistical analysis of vasodilation and flow curves in brachial ultrasonography: technique and its connection to cardiovascular risk factors

    Science.gov (United States)

    Boisrobert, Loic; Laclaustra, Martin; Bossa, Matias; Frangi, Andres G.; Frangi, Alejandro F.

    2005-04-01

    Clinical studies report that impaired endothelial function is associated with Cardio-Vascular Diseases (CVD) and their risk factors. One commonly used mean for assessing endothelial function is Flow-Mediated Dilation (FMD). Classically, FMD is quantified using local indexes e.g. maximum peak dilation. Although such parameters have been successfully linked to CVD risk factors and other clinical variables, this description does not consider all the information contained in the complete vasodilation curve. Moreover, the relation between flow impulse and the vessel vasodilation response to this stimulus, although not clearly known, seems to be important and is not taken into account in the majority of studies. In this paper we propose a novel global parameterization for the vasodilation and the flow curves of a FMD test. This parameterization uses Principal Component Analysis (PCA) to describe independently and jointly the variability of flow and FMD curves. These curves are obtained using computerized techniques (based on edge detection and image registration, respectively) to analyze the ultrasound image sequences. The global description obtained through PCA yields a detailed characterization of the morphology of such curves allowing the extraction of intuitive quantitative information of the vasodilation process and its interplay with flow changes. This parameterization is consistent with traditional measurements and, in a database of 177 subjects, seems to correlate more strongly (and with more clinical parameters) than classical measures to CVD risk factors and clinical parameters such as LDL- and HDL-Cholesterol.

  16. Statistical correlations and risk analyses techniques for a diving dual phase bubble model and data bank using massively parallel supercomputers.

    Science.gov (United States)

    Wienke, B R; O'Leary, T R

    2008-05-01

    Linking model and data, we detail the LANL diving reduced gradient bubble model (RGBM), dynamical principles, and correlation with data in the LANL Data Bank. Table, profile, and meter risks are obtained from likelihood analysis and quoted for air, nitrox, helitrox no-decompression time limits, repetitive dive tables, and selected mixed gas and repetitive profiles. Application analyses include the EXPLORER decompression meter algorithm, NAUI tables, University of Wisconsin Seafood Diver tables, comparative NAUI, PADI, Oceanic NDLs and repetitive dives, comparative nitrogen and helium mixed gas risks, USS Perry deep rebreather (RB) exploration dive,world record open circuit (OC) dive, and Woodville Karst Plain Project (WKPP) extreme cave exploration profiles. The algorithm has seen extensive and utilitarian application in mixed gas diving, both in recreational and technical sectors, and forms the bases forreleased tables and decompression meters used by scientific, commercial, and research divers. The LANL Data Bank is described, and the methods used to deduce risk are detailed. Risk functions for dissolved gas and bubbles are summarized. Parameters that can be used to estimate profile risk are tallied. To fit data, a modified Levenberg-Marquardt routine is employed with L2 error norm. Appendices sketch the numerical methods, and list reports from field testing for (real) mixed gas diving. A Monte Carlo-like sampling scheme for fast numerical analysis of the data is also detailed, as a coupled variance reduction technique and additional check on the canonical approach to estimating diving risk. The method suggests alternatives to the canonical approach. This work represents a first time correlation effort linking a dynamical bubble model with deep stop data. Supercomputing resources are requisite to connect model and data in application.

  17. Positron Annihilation in the Bipositronium Ps2

    Energy Technology Data Exchange (ETDEWEB)

    Bailey, David H.; Frolov, Alexei M.

    2005-07-01

    The electron-positron-pair annihilation in the bipositronium PS2 is considered. In particular, the two-, three-, one- and zero-photon annihilation rates are determined to high accuracy. The corresponding analytical expressions are also presented. Also, a large number of bound state properties have been determined for this system.

  18. The 4 Ps as a Guiding Perspective

    Science.gov (United States)

    Kalsbeek, David H.

    2013-01-01

    A 4 Ps perspective addresses immediate needs: to help institutions gain traction in their retention strategies by framing and reframing the challenges and the possible responses, by challenging some of the traditional mental models about retention that can distract or dilute those strategies, and by offering focus and coherence to institutional…

  19. 10th Anniversary P.S.

    CERN Multimedia

    Adams,J

    1969-01-01

    John Adams parle de la préhistoire du P.S. avec présentation des dias. Le DG B.Gregory prend la parole. Les organisateurs présentent sous la direction du "Prof.Ocktette"(?) un sketch très humoristique (p.e.existence de Quark etc.....)

  20. Back to work for the PS

    CERN Multimedia

    2006-01-01

    On 22 June, the PS's rotating machine started turning again for the first time since its enforced shutdown one month ago (see Bulletin No. 23-24/2006) - and the PS was back in operation the very next day! A team from Siemens worked their socks off, 6 days a week for one month (including public holidays), to repair the electrical power supply in collaboration with the AB/PO Group's Main Power Converters (MPC) Section. The generator's faulty rotor was dismantled and replaced by the renovated spare rotor. The multitude of electrical and mechanical connections together with the sheer weight of the rotor (80 tonnes) made this an extremely complex job. The AB/PO Group used the shutdown to test a back-up solution for the PS power supply. The accelerator was directly wired up to the 18 kV electrical network via a 13 MVA transformer, installed at the end of the 1970s but never used. This solution succeeded in bringing the PS back into operation but at limited energy and frequency. Just 14 GeV could be achieved, whic...

  1. Quality characterization and pollution source identification of surface water using multivariate statistical techniques, Nalagarh Valley, Himachal Pradesh, India

    Science.gov (United States)

    Herojeet, Rajkumar; Rishi, Madhuri S.; Lata, Renu; Dolma, Konchok

    2017-09-01

    multivariate techniques for reliable quality characterization of surface water quality to develop effective pollution reduction strategies and maintain a fine balance between the industrialization and ecological integrity.

  2. Assessment of natural radioactivity and function of minerals in soils of Yelagiri hills, Tamilnadu, India by Gamma Ray spectroscopic and Fourier Transform Infrared (FTIR) techniques with statistical approach.

    Science.gov (United States)

    Chandrasekaran, A; Ravisankar, R; Rajalakshmi, A; Eswaran, P; Vijayagopal, P; Venkatraman, B

    2015-02-05

    Gamma Ray and Fourier Transform Infrared (FTIR) spectroscopic techniques were used to evaluate the natural radioactivity due to natural radionuclides and mineralogical characterization in soils of Yelagiri hills, Tamilnadu, India. Various radiological parameters were calculated to assess the radiation hazards associated with the soil. The distribution pattern of activity due to natural radionuclides is explained by Kriging method of mapping. Using FTIR spectroscopic technique the minerals such as quartz, microcline feldspar, orthoclase feldspar, kaolinite, montmorillonite, illite, and organic carbon were identified and characterized. The extinction coefficient values were calculated to know the relative distribution of major minerals such as quartz, microcline feldspar, orthoclase feldspar and kaolinite. The calculated values indicate that the amount of quartz is higher than orthoclase feldspar, microcline feldspar and much higher than kaolinite. Crystallinity index was calculated to know the crystalline nature of quartz. The result indicates that the presence of disordered crystalline quartz in soils. The relation between minerals and radioactivity was assessed by multivariate statistical analysis (Pearson's correlation and cluster analysis). The statistical analysis confirms that the clay mineral kaolinite and non-clay mineral quartz is the major factor than other major minerals to induce the important radioactivity variables and concentrations of uranium and thorium. Copyright © 2014 Elsevier B.V. All rights reserved.

  3. COLLABORATIVE RESEARCH:USING ARM OBSERVATIONS & ADVANCED STATISTICAL TECHNIQUES TO EVALUATE CAM3 CLOUDS FOR DEVELOPMENT OF STOCHASTIC CLOUD-RADIATION

    Energy Technology Data Exchange (ETDEWEB)

    Somerville, Richard

    2013-08-22

    The long-range goal of several past and current projects in our DOE-supported research has been the development of new and improved parameterizations of cloud-radiation effects and related processes, using ARM data, and the implementation and testing of these parameterizations in global models. The main objective of the present project being reported on here has been to develop and apply advanced statistical techniques, including Bayesian posterior estimates, to diagnose and evaluate features of both observed and simulated clouds. The research carried out under this project has been novel in two important ways. The first is that it is a key step in the development of practical stochastic cloud-radiation parameterizations, a new category of parameterizations that offers great promise for overcoming many shortcomings of conventional schemes. The second is that this work has brought powerful new tools to bear on the problem, because it has been a collaboration between a meteorologist with long experience in ARM research (Somerville) and a mathematician who is an expert on a class of advanced statistical techniques that are well-suited for diagnosing model cloud simulations using ARM observations (Shen).

  4. Multiparametric statistics

    CERN Document Server

    Serdobolskii, Vadim Ivanovich

    2007-01-01

    This monograph presents mathematical theory of statistical models described by the essentially large number of unknown parameters, comparable with sample size but can also be much larger. In this meaning, the proposed theory can be called "essentially multiparametric". It is developed on the basis of the Kolmogorov asymptotic approach in which sample size increases along with the number of unknown parameters.This theory opens a way for solution of central problems of multivariate statistics, which up until now have not been solved. Traditional statistical methods based on the idea of an infinite sampling often break down in the solution of real problems, and, dependent on data, can be inefficient, unstable and even not applicable. In this situation, practical statisticians are forced to use various heuristic methods in the hope the will find a satisfactory solution.Mathematical theory developed in this book presents a regular technique for implementing new, more efficient versions of statistical procedures. ...

  5. Multivariate Analysis, Mass Balance Techniques, and Statistical Tests as Tools in Igneous Petrology: Application to the Sierra de las Cruces Volcanic Range (Mexican Volcanic Belt

    Directory of Open Access Journals (Sweden)

    Fernando Velasco-Tapia

    2014-01-01

    Full Text Available Magmatic processes have usually been identified and evaluated using qualitative or semiquantitative geochemical or isotopic tools based on a restricted number of variables. However, a more complete and quantitative view could be reached applying multivariate analysis, mass balance techniques, and statistical tests. As an example, in this work a statistical and quantitative scheme is applied to analyze the geochemical features for the Sierra de las Cruces (SC volcanic range (Mexican Volcanic Belt. In this locality, the volcanic activity (3.7 to 0.5 Ma was dominantly dacitic, but the presence of spheroidal andesitic enclaves and/or diverse disequilibrium features in majority of lavas confirms the operation of magma mixing/mingling. New discriminant-function-based multidimensional diagrams were used to discriminate tectonic setting. Statistical tests of discordancy and significance were applied to evaluate the influence of the subducting Cocos plate, which seems to be rather negligible for the SC magmas in relation to several major and trace elements. A cluster analysis following Ward’s linkage rule was carried out to classify the SC volcanic rocks geochemical groups. Finally, two mass-balance schemes were applied for the quantitative evaluation of the proportion of the end-member components (dacitic and andesitic magmas in the comingled lavas (binary mixtures.

  6. Phase morphological study on SEBS compatibilized PS/LDPE blends

    Directory of Open Access Journals (Sweden)

    Chatchai Kunyawut

    2014-09-01

    Full Text Available The co-continuous phase morphology of polystyrene (PS/low density polyethylene (LDPE blends compatibilized with poly(styrene-block-ethylene/butylene-block-styrene triblock copolymers (SEBS with varying molecular weights has been investigated. The blend samples were prepared in a mini-twin screw extruder. The barrel length and diameter are 224 and 16 mm, respectively. The diameter of the capillary die is 1 mm. The concentration of the blends was 70/30 wt% of PS/LDPE while that of the SEBS used was 5 wt% of the blend. The mixing temperatures used were 180, 250, and 280o C, and a screw speed of 60 rpm. The morphology of the blends was investigated using an AFM technique. Average droplet diameters of the blend samples were determined using an OM technique. The co-continuous morphology has not been obtained in all the blends, although the mixing temperature used is as high as 280o C. The experimental results indicated that the model prediction of the co-continuous morphology proposed by Willemse and co-worker was not applicable to the blend systems studied. Only droplet-type dispersion was observed. This is considered to arise from the processing conditions and the mixing device used. The blend compatibilized with the high molecular weight SEBS had higher dispersed phase size than that of the blend compatibilized with the medium and low molecular weight SEBSs. This behaviour is likely to arise from coalescence during melt processing.

  7. Statistical atmospheric inversion of local gas emissions by coupling the tracer release technique and local-scale transport modelling: a test case with controlled methane emissions

    Directory of Open Access Journals (Sweden)

    S. Ars

    2017-12-01

    Full Text Available This study presents a new concept for estimating the pollutant emission rates of a site and its main facilities using a series of atmospheric measurements across the pollutant plumes. This concept combines the tracer release method, local-scale atmospheric transport modelling and a statistical atmospheric inversion approach. The conversion between the controlled emission and the measured atmospheric concentrations of the released tracer across the plume places valuable constraints on the atmospheric transport. This is used to optimise the configuration of the transport model parameters and the model uncertainty statistics in the inversion system. The emission rates of all sources are then inverted to optimise the match between the concentrations simulated with the transport model and the pollutants' measured atmospheric concentrations, accounting for the transport model uncertainty. In principle, by using atmospheric transport modelling, this concept does not strongly rely on the good colocation between the tracer and pollutant sources and can be used to monitor multiple sources within a single site, unlike the classical tracer release technique. The statistical inversion framework and the use of the tracer data for the configuration of the transport and inversion modelling systems should ensure that the transport modelling errors are correctly handled in the source estimation. The potential of this new concept is evaluated with a relatively simple practical implementation based on a Gaussian plume model and a series of inversions of controlled methane point sources using acetylene as a tracer gas. The experimental conditions are chosen so that they are suitable for the use of a Gaussian plume model to simulate the atmospheric transport. In these experiments, different configurations of methane and acetylene point source locations are tested to assess the efficiency of the method in comparison to the classic tracer release technique in coping

  8. Reciprocal relationship between APP positioning relative to the membrane and PS1 conformation

    Directory of Open Access Journals (Sweden)

    Jones Phill

    2011-02-01

    Full Text Available Abstract Background Several familial Alzheimer disease (FAD mutations within the transmembrane region of the amyloid precursor protein (APP increase the Aβ42/40 ratio without increasing total Aβ production. In the present study, we analyzed the impact of FAD mutations and γ-secretase modulators (GSMs that alter the Aβ42/40 ratio on APP C-terminus (CT positioning relative to the membrane, reasoning that changes in the alignment of the APP intramembranous domain and presenilin 1 (PS1 may impact the PS1/γ-secretase cleavage site on APP. Results By using a Förster resonance energy transfer (FRET-based technique, fluorescent lifetime imaging microscopy (FLIM, we show that Aβ42/40 ratio-modulating factors which target either APP substrate or PS1/γ-secretase affect proximity of the APP-CT to the membrane and change PS1 conformation. Conclusions Thus, we propose that there is a reciprocal relationship between APP-CT positioning relative to the membrane and PS1 conformation, suggesting that factors that modulate either APP positioning in the membrane or PS1 conformation could be exploited therapeutically.

  9. Efficient genomic correction methods in human iPS cells using CRISPR-Cas9 system.

    Science.gov (United States)

    Li, Hongmei Lisa; Gee, Peter; Ishida, Kentaro; Hotta, Akitsu

    2016-05-15

    Precise gene correction using the CRISPR-Cas9 system in human iPS cells holds great promise for various applications, such as the study of gene functions, disease modeling, and gene therapy. In this review article, we summarize methods for effective editing of genomic sequences of iPS cells based on our experiences correcting dystrophin gene mutations with the CRISPR-Cas9 system. Designing specific sgRNAs as well as having efficient transfection methods and proper detection assays to assess genomic cleavage activities are critical for successful genome editing in iPS cells. In addition, because iPS cells are fragile by nature when dissociated into single cells, a step-by-step confirmation during the cell recovery process is recommended to obtain an adequate number of genome-edited iPS cell clones. We hope that the techniques described here will be useful for researchers from diverse backgrounds who would like to perform genome editing in iPS cells. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

  10. Induced Pluripotent Stem (iPS) Cells in Dentistry: A Review.

    Science.gov (United States)

    Malhotra, Neeraj

    2016-11-30

    iPS cells are derived from somatic cells via transduction and expression of selective transcription factors. Both viral-integrating (like retroviral) and non-integrating (like, mRNA or protein-based) techniques are available for the production of iPS cells. In the field of dentistry, iPS cells have been derived from stem cells of apical papilla, dental pulp stem cells, and stem cells from exfoliated deciduous teeth, gingival and periodontal ligament fibroblasts, and buccal mucosa fibroblasts. iPS cells have the potential to differentiate into all derivatives of the 3 primary germ layers i.e. ectoderm, endoderm, and mesoderm. They are autogeneically accessible, and can produce patient-specific or disease-specific cell lines without the issue of ethical controversy. They have been successfully tested to produce mesenchymal stem cells-like cells, neural crest-like cells, ameloblasts-like cells, odontoblasts-like cells, and osteoprogenitor cells. These cells can aid in regeneration of periodontal ligament, alveolar bone, cementum, dentin-pulp complex, as well as possible Biotooth formation. However certain key issues like, epigenetic memory of iPS cells, viral-transduction, tumorgenesis and teratoma formation need to be overcome, before they can be successfully used in clinical practice. The article discusses the sources, pros and cons, and current applications of iPS cells in dentistry with an emphasis on encountered challenges and their solutions.

  11. PS overcomes two serious magnet failures

    CERN Multimedia

    Maximilien Brice

    2003-01-01

    Two magnets (no.'s 6 and 19)and a bus bar connection in the PS were found to be faulty during high-voltage tests at the end of the accelerator shutdown. A five-week repair schedule was quickly devised. A team of mechanics, technicians and engineers worked at full speed to replace the faulty magnets, succeeding in limiting the delay of the accelerators' spring start-up to two weeks. Pictured here are members of the PS team with the replacement no. 6 magnet. From left to right: In the back row, Frédéric Roussel (Transport DBS), Yves Bernard (Transport DBS), Luc Moreno (Cegelec), Thierry Battimanza (Transport DBS), Raymond Brown (AB/ABP), Thomas Zickler (AT/MEL); at the front, Steven Southern (AT/VAC), Thierry Gaidon (Brun & Sorensen), Philippe Vidales (Cegelec), Daniel Aubert (Cegelec), Jerome Cachet (Transport DBS), Jose Manual Gomes de Faria (AT/MEL), Eric Page (AT/VAC).

  12. Sub-10ps monolithic and low-power photodetector readout

    Energy Technology Data Exchange (ETDEWEB)

    Varner, Gary S.; Ruckman, Larry L.

    2009-02-20

    Recent advances in photon detectors have resulted in high-density imaging arrays that offer many performance and cost advantages. In particular, the excellent transit time spread of certain devices show promise to provide tangible benefits in applications such as Positron Emission Tomography (PET). Meanwhile, high-density, high-performance readout techniques have not kept on pace for exploiting these developments. Photodetector readout for next generation high event rate particle identification and time-resolved PET requires a highly-integrated, low-power, and cost-effective readout technique. We propose fast waveform sampling as a method that meets these criteria and demonstrate that sub-10ps resolution can be obtained for an existing device.

  13. Statistical mechanics

    CERN Document Server

    Davidson, Norman

    2003-01-01

    Clear and readable, this fine text assists students in achieving a grasp of the techniques and limitations of statistical mechanics. The treatment follows a logical progression from elementary to advanced theories, with careful attention to detail and mathematical development, and is sufficiently rigorous for introductory or intermediate graduate courses.Beginning with a study of the statistical mechanics of ideal gases and other systems of non-interacting particles, the text develops the theory in detail and applies it to the study of chemical equilibrium and the calculation of the thermody

  14. PS overcomes two serious magnet failures

    CERN Multimedia

    Maximilien Brice

    2003-01-01

    Two magnets and a bus bar connection in the PS were found to be faulty during high-voltage tests at the end of the accelerator shutdown. A five-week repair schedule was quickly devised. A team of mechanics, technicians and engineers worked at full speed to replace the faulty magnets, succeeding in limiting the delay of the accelerators´ spring start-up to two weeks. Here we see one of the replacement magnets (no. 19) being prepared.

  15. The PS overcomes two serious magnet failures

    CERN Multimedia

    2003-01-01

    Two magnets and a bus bar connection in the PS were found to be faulty during high-voltage tests at the end of the accelerator shutdown. A five-week repair schedule was quickly devised. A team of mechanics, technicians and engineers worked at full speed to replace the faulty magnets, succeeding in limiting the delay of the accelerators' spring start-up to two weeks.

  16. Motor-Generator Set, PS Main Supply

    CERN Multimedia

    CERN PhotoLab

    1983-01-01

    This is the "new" motor-generator set. It replaced the previous, original, one which had served from the PS start-up in 1959. Ordered in 1965, installed in 1967, it was brought into operation at the beginning of 1968. Regularly serviced and fitted with modern regulation and controls, it still serves at the time of writing (2006) and promises to serve for several more years, as a very much alive museum-piece. See also 6803016 and 0201010.

  17. Measuring target for the PS Booster

    CERN Multimedia

    1971-01-01

    The measuring target for the PS Booster (originally 800 MeV, now 1.4 GeV). It measures the size of the beam by destroying all particles with amplitudes greater than the size of the fork, the position and width of which are adjustable. The plunging time is only 20 ms and the acceleration at the tip of the fork reaches 90 g. The servo-controlled linear motor is shown detached from the mechanism. See also 7602008.

  18. Memories of the PS and of LEP

    CERN Document Server

    Steinberger, Jack

    2012-01-01

    The CERN PS, which started in 1959, and the Brookhaven AGS in 1960, represented an advance by a factor of more than five in the energy of proton accelerators, from the 5 GeV of the Berkeley Bevatron to about 30 GeV. These accelerators made possible the large progress in our understanding of particles and their interactions over the next two decades, culminating in the electroweak and QCD gauge theories.

  19. PS overcomes two serious magnet failures

    CERN Multimedia

    Maximilien Brice

    2003-01-01

    Two magnets and a bus bar connection in the PS were found to be faulty during high-voltage tests at the end of the accelerator shutdown. A five-week repair schedule was quickly devised. A team of mechanics, technicians and engineers worked at full speed to replace the faulty magnets, succeeding in limiting the delay of the accelerators' spring start-up to two weeks. Here we see one of the replacement magnets (no. 6) being prepared.

  20. Enhanced personal protection system for the PS

    CERN Multimedia

    Caroline Duc

    2013-01-01

    During the first long shutdown (LS1) a new safety system will be installed in the primary beam areas of the PS complex in order to bring the standard of personnel radiation protection at the PS into line with that of the LHC.   Pierre Ninin, deputy group leader of GS-ASE and responsible for the installation of the new PS complex safety system, in front of a new access control system. The LHC access control systems are state-of-the-art, whereas those of the injection chain accelerators were running the risk of becoming obsolete. For the past two years a project to upgrade the access and safety systems of the first links in the LHC accelerator chain has been underway to bring them into compliance with nuclear safety standards. These systems provide the personnel with automatic protection by limiting access to hazardous areas and by ensuring that nobody is present in the areas when the accelerator is in operation. By the end of 2013, the project teams will ha...

  1. Modeling Alzheimer's disease with human induced pluripotent stem (iPS) cells.

    Science.gov (United States)

    Mungenast, Alison E; Siegert, Sandra; Tsai, Li-Huei

    2016-06-01

    In the last decade, induced pluripotent stem (iPS) cells have revolutionized the utility of human in vitro models of neurological disease. The iPS-derived and differentiated cells allow researchers to study the impact of a distinct cell type in health and disease as well as performing therapeutic drug screens on a human genetic background. In particular, clinical trials for Alzheimer's disease (AD) have been failing. Two of the potential reasons are first, the species gap involved in proceeding from initial discoveries in rodent models to human studies, and second, an unsatisfying patient stratification, meaning subgrouping patients based on the disease severity due to the lack of phenotypic and genetic markers. iPS cells overcome this obstacles and will improve our understanding of disease subtypes in AD. They allow researchers conducting in depth characterization of neural cells from both familial and sporadic AD patients as well as preclinical screens on human cells. In this review, we briefly outline the status quo of iPS cell research in neurological diseases along with the general advantages and pitfalls of these models. We summarize how genome-editing techniques such as CRISPR/Cas9 will allow researchers to reduce the problem of genomic variability inherent to human studies, followed by recent iPS cell studies relevant to AD. We then focus on current techniques for the differentiation of iPS cells into neural cell types that are relevant to AD research. Finally, we discuss how the generation of three-dimensional cell culture systems will be important for understanding AD phenotypes in a complex cellular milieu, and how both two- and three-dimensional iPS cell models can provide platforms for drug discovery and translational studies into the treatment of AD. Copyright © 2015 Elsevier Inc. All rights reserved.

  2. A Comparison of the Performance of Advanced Statistical Techniques for the Refinement of Day-ahead and Longer NWP-based Wind Power Forecasts

    Science.gov (United States)

    Zack, J. W.

    2015-12-01

    Predictions from Numerical Weather Prediction (NWP) models are the foundation for wind power forecasts for day-ahead and longer forecast horizons. The NWP models directly produce three-dimensional wind forecasts on their respective computational grids. These can be interpolated to the location and time of interest. However, these direct predictions typically contain significant systematic errors ("biases"). This is due to a variety of factors including the limited space-time resolution of the NWP models and shortcomings in the model's representation of physical processes. It has become common practice to attempt to improve the raw NWP forecasts by statistically adjusting them through a procedure that is widely known as Model Output Statistics (MOS). The challenge is to identify complex patterns of systematic errors and then use this knowledge to adjust the NWP predictions. The MOS-based improvements are the basis for much of the value added by commercial wind power forecast providers. There are an enormous number of statistical approaches that can be used to generate the MOS adjustments to the raw NWP forecasts. In order to obtain insight into the potential value of some of the newer and more sophisticated statistical techniques often referred to as "machine learning methods" a MOS-method comparison experiment has been performed for wind power generation facilities in 6 wind resource areas of California. The underlying NWP models that provided the raw forecasts were the two primary operational models of the US National Weather Service: the GFS and NAM models. The focus was on 1- and 2-day ahead forecasts of the hourly wind-based generation. The statistical methods evaluated included: (1) screening multiple linear regression, which served as a baseline method, (2) artificial neural networks, (3) a decision-tree approach called random forests, (4) gradient boosted regression based upon an decision-tree algorithm, (5) support vector regression and (6) analog ensemble

  3. High-Resolution TomoSAR & PS-InSAR Analysis in Urban Areas

    Science.gov (United States)

    Wei, Lianhuan; Liao, Mingsheng; Balz, Timo; Liu, Kang; Jendryke, Michael

    2013-01-01

    The surveillance of urban infrastructures is of great importance. Urban infrastructure monitoring benefits from the launch of the new generation of high-resolution SAR satellites. With high-resolution SAR stacks, even deformation details of different building parts can be observed by PS-InSAR technique. However, high-rise building areas suffer severely from layover effects, which can cause serious phase unwrapping errors in PS-InSAR processing. SAR tomography (TomoSAR) provides a method of overcoming layover effects in urban areas. With tomographic techniques, the 3D distribution of multiple scatterers and their position can be reconstructed. In this poster, the PS-InSAR method is illustrated first, followed with PS-InSAR analysis results in Shanghai. Then, we will describe SAR tomography and why we need TomoSAR, especially in dense cities like Shanghai. Finally, preliminary tomographic results are presented. By combining PS-InSAR and TomoSAR, a 4D dynamic mapping of urban areas could be executed.

  4. Experimental statistics

    CERN Document Server

    Natrella, Mary Gibbons

    1963-01-01

    Formulated to assist scientists and engineers engaged in army ordnance research and development programs, this well-known and highly regarded handbook is a ready reference for advanced undergraduate and graduate students as well as for professionals seeking engineering information and quantitative data for designing, developing, constructing, and testing equipment. Topics include characterizing and comparing the measured performance of a material, product, or process; general considerations in planning experiments; statistical techniques for analyzing extreme-value data; use of transformations

  5. Assessment of Coastal and Urban Flooding Hazards Applying Extreme Value Analysis and Multivariate Statistical Techniques: A Case Study in Elwood, Australia

    Science.gov (United States)

    Guimarães Nobre, Gabriela; Arnbjerg-Nielsen, Karsten; Rosbjerg, Dan; Madsen, Henrik

    2016-04-01

    Traditionally, flood risk assessment studies have been carried out from a univariate frequency analysis perspective. However, statistical dependence between hydrological variables, such as extreme rainfall and extreme sea surge, is plausible to exist, since both variables to some extent are driven by common meteorological conditions. Aiming to overcome this limitation, multivariate statistical techniques has the potential to combine different sources of flooding in the investigation. The aim of this study was to apply a range of statistical methodologies for analyzing combined extreme hydrological variables that can lead to coastal and urban flooding. The study area is the Elwood Catchment, which is a highly urbanized catchment located in the city of Port Phillip, Melbourne, Australia. The first part of the investigation dealt with the marginal extreme value distributions. Two approaches to extract extreme value series were applied (Annual Maximum and Partial Duration Series), and different probability distribution functions were fit to the observed sample. Results obtained by using the Generalized Pareto distribution demonstrate the ability of the Pareto family to model the extreme events. Advancing into multivariate extreme value analysis, first an investigation regarding the asymptotic properties of extremal dependence was carried out. As a weak positive asymptotic dependence between the bivariate extreme pairs was found, the Conditional method proposed by Heffernan and Tawn (2004) was chosen. This approach is suitable to model bivariate extreme values, which are relatively unlikely to occur together. The results show that the probability of an extreme sea surge occurring during a one-hour intensity extreme precipitation event (or vice versa) can be twice as great as what would occur when assuming independent events. Therefore, presuming independence between these two variables would result in severe underestimation of the flooding risk in the study area.

  6. Psühhodramaatikud annavad Pärnus eksami

    Index Scriptorium Estoniae

    2008-01-01

    29. maist kuni 1. juunini kestab Pärnus psühhodraama konverents "Geeniuste kohtumine", kus rahvusvahelise koolituse läbinud annavad eksami. Ruuda Palmquist on psühhodraama kui teadusharu rajajaid Eestis. Pärnus on kohal Rootsi Moreno Instituudi juhataja, psühhodraama lavastaja Marc Treadwell

  7. Remote sensing estimation of the total phosphorus concentration in a large lake using band combinations and regional multivariate statistical modeling techniques.

    Science.gov (United States)

    Gao, Yongnian; Gao, Junfeng; Yin, Hongbin; Liu, Chuansheng; Xia, Ting; Wang, Jing; Huang, Qi

    2015-03-15

    Remote sensing has been widely used for ater quality monitoring, but most of these monitoring studies have only focused on a few water quality variables, such as chlorophyll-a, turbidity, and total suspended solids, which have typically been considered optically active variables. Remote sensing presents a challenge in estimating the phosphorus concentration in water. The total phosphorus (TP) in lakes has been estimated from remotely sensed observations, primarily using the simple individual band ratio or their natural logarithm and the statistical regression method based on the field TP data and the spectral reflectance. In this study, we investigated the possibility of establishing a spatial modeling scheme to estimate the TP concentration of a large lake from multi-spectral satellite imagery using band combinations and regional multivariate statistical modeling techniques, and we tested the applicability of the spatial modeling scheme. The results showed that HJ-1A CCD multi-spectral satellite imagery can be used to estimate the TP concentration in a lake. The correlation and regression analysis showed a highly significant positive relationship between the TP concentration and certain remotely sensed combination variables. The proposed modeling scheme had a higher accuracy for the TP concentration estimation in the large lake compared with the traditional individual band ratio method and the whole-lake scale regression-modeling scheme. The TP concentration values showed a clear spatial variability and were high in western Lake Chaohu and relatively low in eastern Lake Chaohu. The northernmost portion, the northeastern coastal zone and the southeastern portion of western Lake Chaohu had the highest TP concentrations, and the other regions had the lowest TP concentration values, except for the coastal zone of eastern Lake Chaohu. These results strongly suggested that the proposed modeling scheme, i.e., the band combinations and the regional multivariate

  8. Development of an indicator of propensity to energy commercial losses using geospatial statistical techniques and socio-economic data: the case of AES Eletropaulo

    Directory of Open Access Journals (Sweden)

    Eduardo de Rezende Francisco

    2010-08-01

    Full Text Available Given the growing importance of integrating marketing and operations indicators to enhance business performance, and the availability of sophisticated geospatial statistical techniques, this paper draws on these concepts to develop an indicator of propensity to energy commercial losses. Loss management is a strategic topic among energy distribution companies, in particular for AES Eletropaulo. In such context, this work’s objectives are: (i to appropriate spatial auto-regressive models and geographically weighted regression (GWR in measuring the cultural influence of neighborhood in customer behavior in the energy fraud act; (ii to replace slum coverage areas by a regional social vulnerability index; and (iii to associate energy loss with customer satisfaction indicators, in a spatial-temporal approach. Spatial regression techniques are revised, followed by a discussion on social vulnerability and customer satisfaction indicators. Operational data obtained from AES Eletropaulo’s geographical information systems were combined with secondary data in order to generate predictive regression models, having energy loss as the response variable. Results show that the incorporation of market and social oriented data about customers substantially contribute to explicate energy loss – the coefficient of determination in the regression models rose from 17.76% to 63.29% when the simpler model was compared to the more complex one. Suggestions are made for future work and opportunities for the replication of the methodology in comparable contexts are discussed.

  9. Comparison of image quality between filtered back-projection and the adaptive statistical and novel model-based iterative reconstruction techniques in abdominal CT for renal calculi.

    Science.gov (United States)

    Vardhanabhuti, Varut; Ilyas, Sumaira; Gutteridge, Catherine; Freeman, Simon J; Roobottom, Carl A

    2013-10-01

    To compare image quality on computed tomographic (CT) images acquired with filtered back-projection (FBP), adaptive statistical iterative reconstruction (ASIR) and model-based iterative reconstruction (MBIR) techniques in CT kidney/ureter/bladder (KUB) examination. Eighteen patients underwent standard protocol CT KUB at our institution. The same raw data were reconstructed using FBP, ASIR and MBIR. Objective [mean image noise, contrast-to-noise ratio (CNR) for kidney and mean attenuation values of subcutaneous fat] and subjective image parameters (image noise, image contrast, overall visibility of kidneys/ureters/bladder, visibility of small structures, and overall diagnostic confidence) were assessed using a scoring system from 1 (best) to 5 (worst). Objective image measurements revealed significantly less image noise and higher CNR and the same fat attenuation values for the MBIR technique (P ASIR and 3.08-3.31 for FBP. No significant difference was observed between FBP and ASIR (P > 0.05), while there was a significant difference between ASIR vs. MBIR (P ASIR and FBP CT KUB examinations. • There are many reconstruction options in CT. • Novel model-based iterative reconstruction (MBIR) showed the least noise and optimal image quality. • For CT of the kidneys/ureters/bladder, MBIR should be utilised, if available. • Further studies to reduce the dose while maintaining image quality should be pursued.

  10. Psychometric properties of the French translation of the reduced KOOS and HOOS (KOOS-PS and HOOS-PS)

    DEFF Research Database (Denmark)

    Ornetti, P; Perruccio, A V; Roos, E M

    2009-01-01

    OBJECTIVE: To evaluate the psychometric properties of the French KOOS physical function (KOOS-PS) and HOOS physical function (HOOS-PS), specifically its feasibility, reliability, construct validity, and responsiveness. METHODS: Consecutive outpatients consulting for primary knee or hip osteoarthr......OBJECTIVE: To evaluate the psychometric properties of the French KOOS physical function (KOOS-PS) and HOOS physical function (HOOS-PS), specifically its feasibility, reliability, construct validity, and responsiveness. METHODS: Consecutive outpatients consulting for primary knee or hip...

  11. Evolving science enhanced with iPS

    Directory of Open Access Journals (Sweden)

    Editor

    2007-11-01

    Full Text Available Dear friends, Greetings from all in the team. With the stage set for online submissions and the review-response-revision-resubmission process standardized, we have come with the first regular issue and from now there will be quarterly issues of the journal. Since the starting of the JSRM in a short span there have been a lot of developments, which we would rather say as "evolutions" keeping in mind, the recent iPS! This evolution we would like you to see from a background of the various developments in the art and science of medicine throughout in the past three centuries. We have come across the era of investigative tools such as bamboo made laryngoscopes to era of vaccines and antibiotics followed by the era of revolutionary non-invasive procedures and recently the nano technology based drugs and now the iPS! Macro to Micro, but still more to go. All through the influence of the society, religions, philosophies have been playing a very important role in every step the science of biology moves ahead. Starting with the contraception, assisted reproduction then the gene modified plants....and now the embryonic stem cells! With the advent of the iPS, though the issues of oncogenes, teratoma yet to be ruled out, we have found there is a way which can bypass the ES cells! Hats off to those scientists who have burnt their midnight oil to have found this way out! The lesson we learn is to explore things with an open mind and continue to proceed further without spending much time fingers crossed. Yours sincerely,The Editorial team.

  12. Comparison of implosion core metrics: A 10 ps dilation X-ray imager vs a 100 ps gated microchannel plate

    Science.gov (United States)

    Nagel, S. R.; Benedetti, L. R.; Bradley, D. K.; Hilsabeck, T. J.; Izumi, N.; Khan, S.; Kyrala, G. A.; Ma, T.; Pak, A.

    2016-11-01

    The dilation x-ray imager (DIXI) [T. J. Hilsabeck et al., Rev. Sci. Instrum. 81, 10E317 (2010); S. R. Nagel et al., ibid. 83, 10E116 (2012); S. R. Nagel et al., ibid. 85, 11E504 (2014)] is a high-speed x-ray framing camera that uses the pulse-dilation technique to achieve a temporal resolution of less than 10 ps. This is a 10 × improvement over conventional framing cameras currently employed on the National Ignition Facility (NIF) (100 ps resolution), and otherwise only achievable with 1D streaked imaging. A side effect of the dramatically reduced gate width is the comparatively lower detected signal level. Therefore we implement a Poisson noise reduction with non-local principal component analysis method [J. Salmon et al., J. Math. Imaging Vision 48, 279294 (2014)] to improve the robustness of the DIXI data analysis. Here we present results on ignition-relevant experiments at the NIF using DIXI. In particular we focus on establishing that/when DIXI gives reliable shape metrics (P0, P2, and P4 Legendre modes, and their temporal evolution/swings).

  13. Position pickup of the PS Booster

    CERN Multimedia

    CERN PhotoLab

    1975-01-01

    The beam position around the 4 rings of the PS Booster (originally 800 MeV, now 1.4 GeV), is measured with electrostatic pickups (PU). They consist of a ceramic cylinder forming part of the vacuum chamber, and, in order to save space, they are located inside the multipole lenses. The inside of the ceramic is coated with a metallic layer, into which the form of the electrodes was cut by computer-controlled micro-sandblasting. Each PU has a pair of horizontal and a pair of vertical electrodes, as well as a separate intensity-sensing circular electrode.

  14. MoS2 PARTICLES MODIFIED WITH POLYSTYRENE FOR PRODUCING Ni–PS/MoS2 COATINGS

    OpenAIRE

    ZHONGJIA HUANG; DANGSHENG XIONG

    2008-01-01

    The MoS2 particles were coated with polystyrene and can be written as PS/MoS2 hereinafter. Ni–PS/MoS2 coatings and Ni–MoS2 coatings were produced by PC electrodeposition technique. The surface morphology of Ni–PS/MoS2 coating was examined and compared with those of Ni–MoS2 coating. The effect of particle concentrations on the volume percent of particles incorporated in the coatings was investigated. And the microhardness of coatings was also investigated. Results show that the surface morphol...

  15. Green feasible route preparation for PMMA vs PS: Its properties for photonic crystal application

    Science.gov (United States)

    Azman, Nursyafiqa; Kassim, Syara; Azwa, Rabiatul Addawiyah; Harun, Noor Aniza

    2017-09-01

    This paper discusses a novel way to make photonic crystal by using poly (methyl methacrylate) (PMMA) and polystyrene (PS) colloidal particle. Both synthesis were through surfactant free-emulsion polymerization. This synthesis is so-called "green process" by having water as a medium instead of using solvent. Conventional polymerization technique mostly uses surfactant as a stabilizer to complete the polymerization process. However, the presence of surfactant may contaminate to the end product and difficult to control the size of colloidal sphere. The detailed morphology of uniform size 386 nm PMMA vs 420 nm PS will be discussed for its further potential photonic application.

  16. PAN/PS elctrospun fibers for oil spill cleanup

    Science.gov (United States)

    Ying, Qiao; Lili, Zhao; Haixiang, Sun; Peng, Li

    2014-08-01

    A high-capacity oil sorbent was fabricated by electrospinning using PS/PAN blend. Morphology, contact angle and oil adsorption of PAN/PS fiber and PP nonwoven fabric were studied. It was found that the PAN/PS fiber had a smaller diameter than PP, and the maximum sorption capacities of the PAN/PS sorbent for pump oil, peanut oil, diesel, and gasoline were 194.85, 131.7, 66.75, and 43.38 g/g, which were far higher than those of PP. The sorbent PS/PAN fiber showed a contact angle of water144.32° and diesel oil 0°. The sorption kinetics of PAN/PS and PP sorbent were also investigated. Compared with the commercial PP fabric, the PAN/PS fiber seems to have the ability to be used in oil-spill cleanup application.

  17. Chemotherapy and quality of life in NSCLC PS 2 patients

    DEFF Research Database (Denmark)

    Helbekkmo, Nina; Strøm, Hans H; Sundstrøm, Stein H

    2009-01-01

    INTRODUCTION: Nearly 40% of patients with advanced NSCLC are in performance status (PS) 2. These patients have a shorter life expectancy than PS 0/1 patients and they are underrepresented in clinical trials. Data on how platinum-based combination chemotherapy affects Health Related Quality of Life...... (HRQOL) of patients with PS 2 are scarce and the treatment of this important group of patients is controversial. METHODS: A national multicenter phase III study on platinum based chemotherapy to 432 advanced NSCLC patients included 123 patients with PS 2. To explore the treatment impact on HRQOL......: Whereas the demographic data at baseline were well balanced between the groups, the PS 2 patients had significantly worse function and more severe symptoms than the PS 0/1 patients. In response to combination chemotherapy, the PS 2 patients had a more profound improvement of global QOL, cognitive function...

  18. [Combined use of wide-detector and adaptive statistical iterative reconstruction-V technique in abdominal CT with low radiation dose].

    Science.gov (United States)

    Wang, H X; Lü, P J; Yue, S W; Chang, L Y; Li, Y; Zhao, H P; Li, W R; Gao, J B

    2017-12-05

    Objective: To investigate the image quality and radiation dose with wide-detector(80 mm) and adaptive statistical iterative reconstruction-V (ASIR-V) technique at abdominal contrast enhanced CT scan. Methods: In the first phantom experiment part, the percentage of ASIR-V for half dose of combined wide detector with ASIR-V technique as compared with standard-detector (40 mm) technique was determined. The human experiment was performed based on the phantom study, 160 patients underwent contrast-enhanced abdominal CT scan were prospectively collected and divided into the control group (n=40) with image reconstruction using 40% ASIR (group A) and the study group (n=120) with random number table. According to pre-ASIR-V percentage, the study group was assigned into three groups[40 cases in each group, group B: 0 pre-ASIR-V scan with image reconstruction of 0-100% post-ASIR-V (interval 10%, subgroups B0-B10); group C: 20% pre-ASIR-V with 20%, 40% and 60% post-ASIR-V (subgroups C1-C3); group D: 40%pre-ASIR-V with 40% and 60% post-ASIR-V (subgroups D1-D2)]. Image noise, CT attenuation values and CNR of the liver, pancreas, aorta and portal vein were compared by using two sample t test and One-way ANOVA. Qualitative visual parameters (overall image quality as graded on a 5-point scale) was compared by Mann-Whitney U test and Kruskal-Wallis H test. Results: The phantom experiment showed that the percentage of pre-ASIR-V for half dose was 40%. With the 40% pre-ASIR-V, radiation dose in the study group was reduced by 35.5% as compared with the control group. Image noise in the subgroups of B2-B10, C2-C3 and D1-D2 were lower (t=-14.681--3.046, all P0.05). The subjective image quality scores increased gradually in the range of 0-60% post-ASIR-V and decreased with post-ASIR-V larger than 70%. The overall image quality of subgroup B3-B8, C2-C3 and D1-D2 were higher than that in group A (Z=-2.229--6.533, all PV technique with 60% post-ASIR-V image reconstruction can reduce

  19. Mathematical and statistical analysis

    Science.gov (United States)

    Houston, A. Glen

    1988-01-01

    The goal of the mathematical and statistical analysis component of RICIS is to research, develop, and evaluate mathematical and statistical techniques for aerospace technology applications. Specific research areas of interest include modeling, simulation, experiment design, reliability assessment, and numerical analysis.

  20. The PS Booster Fast Wire Scanner

    CERN Document Server

    Burger, S; Priestnall, K; Raich, U

    2003-01-01

    The very tight emittance budget for LHC type beams makes precise emittance measurements in the injector complex a necessity. The PS machine uses 2 fast wire scanners per transverse plane for emittance measurement of the circulating beams. In order to ease comparison the same type of wire scanners have been newly installed in the upstream machine, the PS Booster, where each of the 4 rings is equipped with 2 wire scanners measuring the horizontal and vertical profiles. Those wire scanners use new and more modern control and readout electronics featuring dedicated intelligent motor movement controllers, which relieves the very stringent real time constraints due to the very high speed of 20m/s. In order to be able to measure primary beams at the very low injection energy of the Booster (50MeV) secondary emission currents from the wire can be measured as well as secondary particle flows at higher primary particle energies during and after acceleration. The solution adopted for the control of the devices is descri...

  1. Sofrimento psíquico e trabalho

    Directory of Open Access Journals (Sweden)

    Sarah Rosa Salles Vieira

    2014-03-01

    Full Text Available O presente artigo aprofunda questões clínico-téoricas relacionadas especificamente ao trabalho docente e ao sofrimento psíquico a ele relacionado a partir da observação clínica e vivência grupal nos atendimentos terapêuticos ocupacionais realizados no Hospital do Servidor Público Estadual de São Paulo "Francisco Morato de Oliveira" (HSPE-FMO. Partindo dos estudos acerca da Psicopatologia do Trabalho de Christophe Dejours, do trabalho docente e do relato de um caso clínico, caracteriza a problemática do sofrimento no trabalho, os sistemas de defesa contra este sofrimento, a ameaça à subjetividade do próprio trabalhador, as representações e conflitos vivenciados no trabalho docente, bem como a relação aditiva estabelecida como uma estratégia inconsciente de sobrevivência psíquica.

  2. Improving the sampling strategy of the Joint Danube Survey 3 (2013) by means of multivariate statistical techniques applied on selected physico-chemical and biological data.

    Science.gov (United States)

    Hamchevici, Carmen; Udrea, Ion

    2013-11-01

    The concept of basin-wide Joint Danube Survey (JDS) was launched by the International Commission for the Protection of the Danube River (ICPDR) as a tool for investigative monitoring under the Water Framework Directive (WFD), with a frequency of 6 years. The first JDS was carried out in 2001 and its success in providing key information for characterisation of the Danube River Basin District as required by WFD lead to the organisation of the second JDS in 2007, which was the world's biggest river research expedition in that year. The present paper presents an approach for improving the survey strategy for the next planned survey JDS3 (2013) by means of several multivariate statistical techniques. In order to design the optimum structure in terms of parameters and sampling sites, principal component analysis (PCA), factor analysis (FA) and cluster analysis were applied on JDS2 data for 13 selected physico-chemical and one biological element measured in 78 sampling sites located on the main course of the Danube. Results from PCA/FA showed that most of the dataset variance (above 75%) was explained by five varifactors loaded with 8 out of 14 variables: physical (transparency and total suspended solids), relevant nutrients (N-nitrates and P-orthophosphates), feedback effects of primary production (pH, alkalinity and dissolved oxygen) and algal biomass. Taking into account the representation of the factor scores given by FA versus sampling sites and the major groups generated by the clustering procedure, the spatial network of the next survey could be carefully tailored, leading to a decreasing of sampling sites by more than 30%. The approach of target oriented sampling strategy based on the selected multivariate statistics can provide a strong reduction in dimensionality of the original data and corresponding costs as well, without any loss of information.

  3. Emerging ps-TW CO{sub 2} laser technology for high energy physics applications

    Energy Technology Data Exchange (ETDEWEB)

    Pogorelsky, I.V.

    1998-02-01

    A brief overview of laser acceleration techniques and a comparative analysis of the picosecond terawatt (ps-TW) CO{sub 2} laser technology versus T{sup 3} solid state lasers for prospective HEP applications. Special attention is given to two laser accelerator schemes. The first one is the far-field staged laser accelerator, STELLA, which is under exploration at the ATF using a CO{sub 2} laser. The second is a laser wakefield accelerator where ps-TW CO{sub 2} lasers have a great potential. Inverse to the laser accelerator, a prospective monochromatic x-ray source feasible at the ATF will also utilize a 50 MeV subpicosecond electron beam and the first ps-TW CO{sub 2} laser, PITER I.

  4. Radar interferometry persistent scatterer technique

    CERN Document Server

    Kampes, Bert M

    2014-01-01

    This volume is devoted to the Persistent Scatterer Technique, the latest development in radar interferometric data processing. It is the only book on Permanent Scatterer (PS) technique of radar interferometry, and it details a newly developed stochastic model and estimator algorithm to cope with possible problems for the application of the PS technique. The STUN (spatio-temporal unwrapping network) algorithm, developed to cope with these issues in a robust way, is presented and applied to two test sites.

  5. Use of multivariate statistical techniques for the evaluation of temporal and spatial variations in water quality of the Kaduna River, Nigeria.

    Science.gov (United States)

    Ogwueleka, Toochukwu Chibueze

    2015-03-01

    Multivariate statistical techniques, such as cluster analysis (CA) and principal component analysis/factor analysis (PCA/FA), were used to investigate the temporal and spatial variations and to interpret large and complex water quality data sets collected from the Kaduna River. Kaduna River is the main tributary of Niger River in Nigeria and represents the common situation of most natural rivers including spatial patterns of pollutants. The water samples were collected monthly for 5 years (2008-2012) from eight sampling stations located along the river. In all samples, 17 parameters of water quality were determined: total dissolved solids (TDS), pH, Thard, dissolved oxygen (DO), 5-day biochemical oxygen demand (BOD5), chemical oxygen demand (COD), NH4-N, Cl, SO4, Ca, Mg, total coliform (TColi), turbidity, electrical conductivity (EC), HCO3 (-), NO3 (-), and temperature (T). Hierarchical CA grouped 12 months into two seasons (dry and wet seasons) and classified eight sampling stations into two groups (low- and high-pollution regions) based on seasonal differences and different levels of pollution, respectively. PCA/FA for each group formed by CA helped to identify spatiotemporal dynamics of water quality in Kaduna River. CA illustrated that water quality progressively deteriorated from headwater to downstream areas. The results of PCA/FA determined that 78.7 % of the total variance in low pollution region was explained by five factor, that is, natural and organic, mineral, microbial, organic, and nutrient, and 87.6 % of total variance in high pollution region was explained by six factors, that is, microbial, organic, mineral, natural, nutrient, and organic. Varifactors obtained from FA indicated that the parameters responsible for water quality variations are resulted from agricultural runoff, natural pollution, domestic, municipal, and industrial wastewater. Mann-Whitney U test results revealed that TDS, pH, DO, T, EC, TColi, turbidity, total hardness (THard), Mg

  6. KAJIAN INDUCED PLURIPOTENT STEMCELL (iPS (HARAPAN DAN TANTANGAN

    Directory of Open Access Journals (Sweden)

    Masagus Zainuri

    2014-05-01

    Full Text Available AbstractInduced Pluripotent Stemcell (iPS are adult cells which the genetic information in the nucleus of those cells being reprogrammed (reprogram by inserting exogenous pluripotential genes. The exogenous gene transduction is using vectors, such as lentivirus, retrovirus, or adenovirus, which suppressed the gene expression of the original cells, so they will express the transduced exogenous gene. Viral vectors are then used to reprogramming and producing iPS clones that are pluripotent. iPS derived from adult cells of patient with certain diseases will be used as a tool to study the mechanisms of those specific diseases and the effects of selected drugs against the diseases. Several previous studies have shown that iPS clones developed from specific genetic disease have its original genotype and retain the character of the response to the drug that similar as the original adult cells. Opportunities for the utilization of autologous iPS cell therapy in the future is wide open as expected iPS transplant will not be rejected when transplanted back to the patient. Behind all its potential, iPS production is still facing some problems to be applicable clinically. The use of viruses as vectors may cause problems due to virus gene sequences may be integrated into the genome of the DNA donor cell, thereby causing mutations of the iPS clones. Several subsequent studies have succeeded in replacing the use of viruses as vectors, but the level of efficiency obtained is still very low. Another problem that arises is that epigenetic changes may occur in iPS cultures. Many advanced research related to iPS may be developed in Indonesia and is necessary to improve the production efficiency of iPS and solve iPS clones epigenetic changes problems in the future.Keywords: iPS, pluripotency, transduction, transfection.AbstrakInduced Pluripotent Stemcell (iPS adalah sel somatic dewasa yang informasi genetika dalam inti selnyadiprogram ulang (reprogram dengan cara

  7. Comparison of molecular species of various transphosphatidylated phosphatidylserine (PS) with bovine cortex PS by mass spectrometry

    NARCIS (Netherlands)

    Chen, S.; Li, K.W.

    2008-01-01

    The exogenous introduction of a molecular species mixture of bovine cortex phosphatidylserine (BC-PS) has been claimed to improve memory function in subjects suffering from age-associated memory impairment and dementia. However, it has been also reported that oral administration of another molecular

  8. Design of a Seismic Reflection Multi-Attribute Workflow for Delineating Karst Pore Systems Using Neural Networks and Statistical Dimensionality Reduction Techniques

    Science.gov (United States)

    Ebuna, D. R.; Kluesner, J.; Cunningham, K. J.; Edwards, J. H.

    2016-12-01

    An effective method for determining the approximate spatial extent of karst pore systems is critical for hydrological modeling in such environments. When using geophysical techniques, karst features are especially challenging to constrain due to their inherent heterogeneity and complex seismic signatures. We present a method for mapping these systems using three-dimensional seismic reflection data by combining applications of machine learning and modern data science. Supervised neural networks (NN) have been successfully implemented in seismic reflection studies to produce multi-attributes (or meta-attributes) for delineating faults, chimneys, salt domes, and slumps. Using a seismic reflection dataset from southeast Florida, we develop an objective multi-attribute workflow for mapping karst in which potential interpreter bias is minimized by applying linear and non-linear data transformations for dimensionality reduction. This statistical approach yields a reduced set of input seismic attributes to the NN by eliminating irrelevant and overly correlated variables, while still preserving the vast majority of the observed data variance. By initiating the supervised NN from an eigenspace that maximizes the separation between classes, the convergence time and accuracy of the computations are improved since the NN only needs to recognize small perturbations to the provided decision boundaries. We contend that this 3D seismic reflection, data-driven method for defining the spatial bounds of karst pore systems provides great value as a standardized preliminary step for hydrological characterization and modeling in these complex geological environments.

  9. Industrial statistics with Minitab

    CERN Document Server

    Cintas, Pere Grima; Llabres, Xavier Tort-Martorell

    2012-01-01

    Industrial Statistics with MINITAB demonstrates the use of MINITAB as a tool for performing statistical analysis in an industrial context. This book covers introductory industrial statistics, exploring the most commonly used techniques alongside those that serve to give an overview of more complex issues. A plethora of examples in MINITAB are featured along with case studies for each of the statistical techniques presented. Industrial Statistics with MINITAB: Provides comprehensive coverage of user-friendly practical guidance to the essential statistical methods applied in industry.Explores

  10. Beginning statistics with data analysis

    CERN Document Server

    Mosteller, Frederick; Rourke, Robert EK

    2013-01-01

    This introduction to the world of statistics covers exploratory data analysis, methods for collecting data, formal statistical inference, and techniques of regression and analysis of variance. 1983 edition.

  11. PS main supply: motor-generator set.

    CERN Multimedia

    Maximilien Brice

    2002-01-01

    In picture 04 the motor is on the right in the background and the main view is of the generator. The peak power in each PS cycle drawn from the generator, up to 96 MW, is taken from the rotational kinetic energy of the rotor (a heavy-weight of 80 tons), which makes the rotational speed drop by only a few percent. The motor replenishes the average power of 2 to 4 MW. Photo 05: The motor-generator set is serviced every year and, in particular, bearings and slip-rings are carefully checked. To the left is the motor with its slip-rings visible. It has been detached from the axle and moved to the side, so that the rotor can be removed from the huge generator, looming at the right.

  12. High Resolution TomoSAR & PS-InSAR Analysis in Urban Areas

    Science.gov (United States)

    Wei, Lianhuan; Liao, Mingsheng; Balz, Timo; Liu, Kang; Jendryke, Michael

    2013-01-01

    The surveillance of urban infrastructures is of great importance. Urban infrastructure monitoring benefits from the launch of the new generation of high-resolution SAR satellites. With high-resolution SAR stacks, even deformation details of different building parts can be observed. The PS-InSAR technique has become a favorable tool for urban area subsidence monitoring, and it has been demonstrated that millimeter accuracy can be achieved. However, high-rise building areas suffer severely from layover effects, which can cause serious phase unwrapping errors. SAR tomography provides a method of overcoming layover effects in urban areas. With tomographic techniques, the 3D distribution of multiple scatterers and their position can be reconstructed. In this paper, the PS-InSAR method is briefly described first, followed by PS-InSAR analysis results in Shanghai. Then, we will describe SAR tomography and why we need TomoSAR, especially in dense cities like Shanghai. Finally, preliminary tomographic results about Shanghai are presented. By combining PS-InSAR and TomoSAR, a 4D dynamic mapping of urban areas could be executed.

  13. PS: A nonprocedural language with data types and modules

    Science.gov (United States)

    Gokhale, M. B.

    1986-01-01

    The Problem Specification (PS) nonprocedural language is a very high level language for algorithm specification. PS is suitable for nonprogrammers, who can specify a problem using mathematically-oriented equations; for expert programmers, who can prototype different versions of a software system for evaluation; and for those who wish to use specifications for portions (if not all) of a program. PS has data types and modules similar to Modula-2. The compiler generates C code. PS is first shown by example, and then efficiency issues in scheduling and code generation are discussed.

  14. Distinct iPS Cells Show Different Cardiac Differentiation Efficiency.

    Science.gov (United States)

    Ohno, Yohei; Yuasa, Shinsuke; Egashira, Toru; Seki, Tomohisa; Hashimoto, Hisayuki; Tohyama, Shugo; Saito, Yuki; Kunitomi, Akira; Shimoji, Kenichiro; Onizuka, Takeshi; Kageyama, Toshimi; Yae, Kojiro; Tanaka, Tomofumi; Kaneda, Ruri; Hattori, Fumiyuki; Murata, Mitsushige; Kimura, Kensuke; Fukuda, Keiichi

    2013-01-01

    Patient-specific induced pluripotent stem (iPS) cells can be generated by introducing transcription factors that are highly expressed in embryonic stem (ES) cells into somatic cells. This opens up new possibilities for cell transplantation-based regenerative medicine by overcoming the ethical issues and immunological problems associated with ES cells. Despite the development of various methods for the generation of iPS cells that have resulted in increased efficiency, safety, and general versatility, it remains unknown which types of iPS cells are suitable for clinical use. Therefore, the aims of the present study were to assess (1) the differentiation potential, time course, and efficiency of different types of iPS cell lines to differentiate into cardiomyocytes in vitro and (2) the properties of the iPS cell-derived cardiomyocytes. We found that high-quality iPS cells exhibited better cardiomyocyte differentiation in terms of the time course and efficiency of differentiation than low-quality iPS cells, which hardly ever differentiated into cardiomyocytes. Because of the different properties of the various iPS cell lines such as cardiac differentiation efficiency and potential safety hazards, newly established iPS cell lines must be characterized prior to their use in cardiac regenerative medicine.

  15. Landslide susceptibility assessment in Lianhua County (China): A comparison between a random forest data mining technique and bivariate and multivariate statistical models

    Science.gov (United States)

    Hong, Haoyuan; Pourghasemi, Hamid Reza; Pourtaghi, Zohre Sadat

    2016-04-01

    Landslides are an important natural hazard that causes a great amount of damage around the world every year, especially during the rainy season. The Lianhua area is located in the middle of China's southern mountainous area, west of Jiangxi Province, and is known to be an area prone to landslides. The aim of this study was to evaluate and compare landslide susceptibility maps produced using the random forest (RF) data mining technique with those produced by bivariate (evidential belief function and frequency ratio) and multivariate (logistic regression) statistical models for Lianhua County, China. First, a landslide inventory map was prepared using aerial photograph interpretation, satellite images, and extensive field surveys. In total, 163 landslide events were recognized in the study area, with 114 landslides (70%) used for training and 49 landslides (30%) used for validation. Next, the landslide conditioning factors-including the slope angle, altitude, slope aspect, topographic wetness index (TWI), slope-length (LS), plan curvature, profile curvature, distance to rivers, distance to faults, distance to roads, annual precipitation, land use, normalized difference vegetation index (NDVI), and lithology-were derived from the spatial database. Finally, the landslide susceptibility maps of Lianhua County were generated in ArcGIS 10.1 based on the random forest (RF), evidential belief function (EBF), frequency ratio (FR), and logistic regression (LR) approaches and were validated using a receiver operating characteristic (ROC) curve. The ROC plot assessment results showed that for landslide susceptibility maps produced using the EBF, FR, LR, and RF models, the area under the curve (AUC) values were 0.8122, 0.8134, 0.7751, and 0.7172, respectively. Therefore, we can conclude that all four models have an AUC of more than 0.70 and can be used in landslide susceptibility mapping in the study area; meanwhile, the EBF and FR models had the best performance for Lianhua

  16. UNA TECNICA ESTADISTICA PARA MEDIR LA CONFLICTIVIDAD SOCIAL A TRAVES DEL REGISTRO ARQUEOLOGICO (A Statistical Technique to Measure Social Conflict through the Archaeological Record

    Directory of Open Access Journals (Sweden)

    Pascual Izquierdo-Egea

    2015-03-01

    Full Text Available Se presenta aqui una tecnica estadistica para medir la conflictividad social a traves del registro mortuorio. Nace al amparo del metodo de valoracion contextual empleado en el analisis de los ajuares funerarios desde 1993. Se trata de una herramienta fundamental para el desarrollo de la arqueologia de los fenomenos sociales, cuyos relevantes resultados empiricos avalan su trascendencia teorica. Tras proceder a su conceptualizacion en funcion de la desigualdad social y la riqueza relativa, se explican las dos clases de conflictividad social definidas: estructural o estatica y coyuntural o dinamica. Finalmente, se incluyen sus conexiones con la ley demografica de Malthus a traves de sus dos parametros: poblacion y recursos. Todo este entramado teorico se ilustra con algunas aplicaciones referidas a las civilizaciones antiguas, abarcando la protohistoria iberica, la Mesoamerica prehispanica o la Roma altoimperial. ENGLISH: A statistical technique to measure social conflict through the mortuary record is presented here. It is born under the contextual valuation method used in the analysis of grave goods since 1993. This is a fundamental tool for the development of the archaeology of social phenomena, whose relevant empirical results support its theoretical significance. After conveying its conceptualization in terms of social inequality and relative wealth, the two classes of social conflict are explained: static or structural and dynamic or conjunctural. Finally, connections with the Malthusian demographic law through its two parameters—population and resources—are included. The synthesis of these theoretical frameworks is illustrated with applications to ancient civilizations, including Iberian protohistory, prehispanic Mesoamerica, and early imperial Rome.

  17. DHI evaluation by combining rock physics simulation and statistical techniques for fluid identification of Cambrian-to-Cretaceous clastic reservoirs in Pakistan

    Science.gov (United States)

    Ahmed, Nisar; Khalid, Perveiz; Shafi, Hafiz Muhammad Bilal; Connolly, Patrick

    2017-08-01

    The use of seismic direct hydrocarbon indicators is very common in exploration and reservoir development to minimise exploration risk and to optimise the location of production wells. DHIs can be enhanced using AVO methods to calculate seismic attributes that approximate relative elastic properties. In this study, we analyse the sensitivity to pore fluid changes of a range of elastic properties by combining rock physics studies and statistical techniques and determine which provide the best basis for DHIs. Gassmann fluid substitution is applied to the well log data and various elastic properties are evaluated by measuring the degree of separation that they achieve between gas sands and wet sands. The method has been applied successfully to well log data from proven reservoirs in three different siliciclastic environments of Cambrian, Jurassic, and Cretaceous ages. We have quantified the sensitivity of various elastic properties such as acoustic and extended elastic (EEI) impedances, elastic moduli (K sat and K sat-μ), lambda-mu-rho method (λρ and μρ), P-to-S-wave velocity ratio (V P/V S), and Poisson's ratio (σ) at fully gas/water saturation scenarios. The results are strongly dependent on the local geological settings and our modeling demonstrates that for Cambrian and Cretaceous reservoirs, K sat-μ, EEI, V P/V S, and σ are more sensitive to pore fluids (gas/water). For the Jurassic reservoir, the sensitivity of all elastic and seismic properties to pore fluid reduces due to high overburden pressure and the resultant low porosity. Fluid indicators are evaluated using two metrics: a fluid indicator coefficient based on a Gaussian model and an overlap coefficient which makes no assumptions about a distribution model. This study will provide a potential way to identify gas sand zones in future exploration.

  18. LEADIR-PS: providing unprecedented SMR safety and economics

    Energy Technology Data Exchange (ETDEWEB)

    Hart, R.S., E-mail: N2i2@xplornet.ca [Northern Nuclear Industries Incorporated, Cambridge, ON (Canada)

    2015-07-01

    Northern Nuclear Industries Incorporated (N{sup 2} I{sup 2}) is developing Small Modular Reactors (SMRs) called LEADIR-PS, an acronym for LEAD-cooled Integral Reactor-Passively Safe. LEADIR-PS integrates proven technologies including TRISO fuel, Pebble Bed core and graphite moderator, with molten lead coolant in an integral pool type reactor configuration to achieve unprecedented safety and economics. Plants under development are LEADIR-PS30, producing 30 MWth, LEADIR-PS100 producing 100 MWth and LEADIR-PS300 producing 300 MWth that are focused on serving the energy demands of areas with a small electrical grid and/or process heat applications. A plant consisting of six LEADIR-PS300 reactor modules serving a common turbine-generator, called the LEADIR-PS Six-Pack, is focused on serving areas with higher energy demands and a robust electricity grid. The Gen{sup +} I LEADIR-PS plants are inherently/passively safe. There is no potential for a Loss Of Coolant Accident, a reactivity transient without shutdown, a loss of heat sink, or hydrogen generation. No active systems or operator actions are required to assure safety. The unprecedented safety of LEADIR-PS reactors avoids large exclusion radius and demanding evacuation plan requirements. LEADIR-PS, with steam conditions of 370 {sup o}C and 12 MPa can serve over 85% of the world's non-transportation process heat demands. In Canada, the electricity and process heat demands, ranging from those of remote communities and the oil sands to densely populated areas can be served by LEADIR-PS. (author)

  19. Suitability of the RGB Channels for a Pixel Manipulation in a Spatial Domain Data Hiding Techniques

    Directory of Open Access Journals (Sweden)

    Ante Poljicak

    2010-06-01

    Full Text Available The aim of this research was to determine which channel in rgb color space is the most suitable (regarding perceptibility for a pixel manipulation in a spatial domain data  hiding techniques. For this purpose three custom test targets were generated. The research also shows the behavior of two closely related colors in the ps (Print-Scan process. The results are interpreted using both a quantitative method (statistical comparison and a qualitative method (visual comparison.

  20. RMS Pictorial Scale (RMS-PS: An innovative scale for the assessment of child′s dental anxiety

    Directory of Open Access Journals (Sweden)

    R M Shetty

    2015-01-01

    Full Text Available Background: Dental anxiety assessment for young children is as important as performing their treatment. Appropriate knowledge of patient′s anxiety boosts confidence and will help us to review potential management options specific to every child. Aim: This study aimed to validate (RMS Pictorial Scale (RMS-PS and to compare it with Venham Picture Test (VPT and Facial image scale (FIS in measuring dental anxiety for young children during their first dental visit. Materials and Methods: A total of 102 healthy children aged between 4 and 14 years during their first dental visit were randomly selected for the study. Childs anxiety level was measured using three different scales namely (i RMS-PS (ii VPT, and (iii FIS. Statistical Analysis: Student t test was used to compare the scores obtained from all the three scales. Pearson correlation test was used to obtain correlation among the scales used in the study. Results: A strong correlation (0·76 was found between the VPT and RMS-PS, and a moderate correlation (0.5 was found between RMS-PS and FIS, indicating good validity for the RMS-PS. Conclusions: The findings of this study suggest that the RMS-PS can be a newer and easiest means for the assessment of dental anxiety for young children in a clinical context.

  1. HYBRID GREY WOLF OPTIMIZATION-PATTERN SEARCH (hGWO-PS) OPTIMIZED 2DOF-PID CONTROLLERS FOR LOAD FREQUENCY CONTROL (LFC) IN INTERCONNECTED THERMAL POWER PLANTS

    National Research Council Canada - National Science Library

    V, Soni; G, Parmar; M, Kumar; S, Panda

    2016-01-01

    The combination of Grey Wolf Optimization and Pattern Search Technique (hGWO-PS) has been introduced to optimize the parameters of two Degree of Freedom Proportional-Integral-Derivative Controller (2DOF-PID...

  2. Interleaving of beam lines inside the PS tunnel

    CERN Multimedia

    1983-01-01

    View against the direction of the proton beams. The PS ring (section 26) is on the left. The injection tunnel for LEAR leaving from here has increased the trafic in this already busy area where the two Linacs and the transfer tunnel leading to the SPS, ISR and AA join the PS ring (cf. photo 7802260, 7802261, Annual Report 1981, p. 89, fig. 12).

  3. Modulation of enzymatic PS synthesis by liposome membrane composition.

    Science.gov (United States)

    Pinsolle, Alexandre; Roy, Philippe; Cansell, Maud

    2014-03-01

    Phosphatidylserine (PS) is a phospholipid known to exert important physiological roles in humans. However, this phospholipid (PL) is poorly available as a natural source and hardly produced by the chemical route. In this work, PS was obtained by transphosphatidylation using phospholipase D (PLD) and PL self-assembled into liposomes as the substrates. The aim was to better understand how the liposome membrane composition could modulate PS yield. Three lecithins were used as PL substrates, one originated from a marine source providing a high amount of n-3 polyunsaturated fatty acids, and two issued from soya differing in their phosphatidylcholine (PC) content. Different parameters such as Ca(2+) content, enzyme and L-serine concentrations modulated PS synthesis. The presence of Ca(2+) increased PS conversion yield. The alcohol acceptor (L-serine) concentration positively acted on PL conversion, by governing the equilibrium between transphosphatidylation and hydrolysis. Beside these specific reaction conditions, it was demonstrated that the membrane composition of the liposomes modulated PS synthesis. A direct correlation between PS accumulation and the amount of cholesterol or α-tocopherol incorporated into the soya lecithins was observed. This result was interpreted in terms of "head" spacers promoting PLD transphosphatidylation. On the whole, this work provided key parameters for the formulation of liposomes using enzymatic PLD technology, to produce lecithins enriched in different proportions of PS and esterified with various types of fatty acids depending on the initial lecithin source. Copyright © 2013 Elsevier B.V. All rights reserved.

  4. Spectroscopic Classification of PS16chs with SOAR/Goodman

    Science.gov (United States)

    Miller, J. A.; Hounsell, R. A.; Pan, Y.-C.; Foley, R. J.; Jha, S. W.; Rest, A.; Scolnic, D.

    2016-05-01

    We report the classification of PS16chs from spectroscopic observation with the Goodman spectrograph on the SOAR telescope. The observation was made on 2016 May 08 UT. We classify PS16chs as a SN Ia near maximum light at z = 0.19.

  5. Motor-Generator powering the PS (Proton Synchrotron) main magnets

    CERN Multimedia

    1983-01-01

    This motor-generator,30 MW peak, 1500 r.p.m.,pulsed power supply for the PS main magnet replaced in 1968 the initial 3000 r.p.m. motor-generator-flywheel set which had served from the PS start-up in 1959 until end 1967. See also photo 8302337 and its abstract.

  6. Transfer line TT70 (electrons from PS to SPS)

    CERN Multimedia

    CERN PhotoLab

    1981-01-01

    As injectors for LEP, PS and SPS had to be converted to the acceleration of electrons and positrons. So far, only positively charged particles had been transferred from the PS to the SPS, for the negatively charged electrons a new transfer line, TT70, had to be built. Due to the difference in level of the two machines, the transfer line slopes and tilts.

  7. Psühhodraama - spontaansuse kool / Taimi Elenurm

    Index Scriptorium Estoniae

    Elenurm, Taimi

    2010-01-01

    Viinis ja New Yorgis tegutsenud psühhiaatri Jakob Levy Moreno loodud psühhodraamast, mis võimaldab rollimängu kaudu näha ennast läbi teiste silmade, aga ka vabaneda pingetest andes võimaluse käituda teisiti kui tavaelus

  8. Method for estimating potential wetland extent by utilizing streamflow statistics and flood-inundation mapping techniques: Pilot study for land along the Wabash River near Terre Haute, Indiana

    Science.gov (United States)

    Kim, Moon H.; Ritz, Christian T.; Arvin, Donald V.

    2012-01-01

    Potential wetland extents were estimated for a 14-mile reach of the Wabash River near Terre Haute, Indiana. This pilot study was completed by the U.S. Geological Survey in cooperation with the U.S. Department of Agriculture, Natural Resources Conservation Service (NRCS). The study showed that potential wetland extents can be estimated by analyzing streamflow statistics with the available streamgage data, calculating the approximate water-surface elevation along the river, and generating maps by use of flood-inundation mapping techniques. Planning successful restorations for Wetland Reserve Program (WRP) easements requires a determination of areas that show evidence of being in a zone prone to sustained or frequent flooding. Zone determinations of this type are used by WRP planners to define the actively inundated area and make decisions on restoration-practice installation. According to WRP planning guidelines, a site needs to show evidence of being in an "inundation zone" that is prone to sustained or frequent flooding for a period of 7 consecutive days at least once every 2 years on average in order to meet the planning criteria for determining a wetland for a restoration in agricultural land. By calculating the annual highest 7-consecutive-day mean discharge with a 2-year recurrence interval (7MQ2) at a streamgage on the basis of available streamflow data, one can determine the water-surface elevation corresponding to the calculated flow that defines the estimated inundation zone along the river. By using the estimated water-surface elevation ("inundation elevation") along the river, an approximate extent of potential wetland for a restoration in agricultural land can be mapped. As part of the pilot study, a set of maps representing the estimated potential wetland extents was generated in a geographic information system (GIS) application by combining (1) a digital water-surface plane representing the surface of inundation elevation that sloped in the downstream

  9. Leaching of styrene and other aromatic compounds in drinking water from PS bottles.

    Science.gov (United States)

    Ahmad, Maqbool; Bajahlan, Ahmad S

    2007-01-01

    Bottled water may not be safer, or healthier, than tap water. The present studies have proved that styrene and some other aromatic compounds leach continuously from polystyrene (PS) bottles used locally for packaging. Water sapmles in contact with PS were extracted by a preconcentration technique called as "purge and trap" and analysed by gas chromatograph-mass spectrometer (GC/MS). Eleven aromatic compounds were identified in these studies. Maximum concentration of styrene in PS bottles was 29.5 microg/L. Apart from styrene, ethyl benzene, toluene and benzene were also quantified but their concentrations were much less than WHO guide line values. All other compounds were in traces. Quality of plastic and storage time were the major factor in leaching of styrene. Concentration of styrene was increased to 69.53 microg/L after one-year storage. In Styrofoam and PS cups studies, hot water was found to be contaminated with styrene and other aromatic compounds. It was observed that temperature played a major role in the leaching of styrene monomer from Styrofoam cups. Paper cups were found to be safe for hot drinks.

  10. Au coated PS nanopillars as a highly ordered and reproducible SERS substrate

    Science.gov (United States)

    Kim, Yong-Tae; Schilling, Joerg; Schweizer, Stefan L.; Sauer, Guido; Wehrspohn, Ralf B.

    2017-07-01

    Noble metal nanostructures with nanometer gap size provide strong surface-enhanced Raman scattering (SERS) which can be used to detect trace amounts of chemical and biological molecules. Although several approaches were reported to obtain active SERS substrates, it still remains a challenge to fabricate SERS substrates with high sensitivity and reproducibility using low-cost techniques. In this article, we report on the fabrication of Au sputtered PS nanopillars based on a template synthetic method as highly ordered and reproducible SERS substrates. The SERS substrates are fabricated by anodic aluminum oxide (AAO) template-assisted infiltration of polystyrene (PS) resulting in hemispherical structures, and a following Au sputtering process. The optimum gap size between adjacent PS nanopillars and thickness of the Au layers for high SERS sensitivity are investigated. Using the Au sputtered PS nanopillars as an active SERS substrate, the Raman signal of 4-methylbenzenethiol (4-MBT) with a concentration down to 10-9 M is identified with good signal reproducibility, showing great potential as promising tool for SERS-based detection.

  11. Telomere reprogramming and maintenance in porcine iPS cells.

    Directory of Open Access Journals (Sweden)

    Guangzhen Ji

    Full Text Available Telomere reprogramming and silencing of exogenous genes have been demonstrated in mouse and human induced pluripotent stem cells (iPS cells. Pigs have the potential to provide xenotransplant for humans, and to model and test human diseases. We investigated the telomere length and maintenance in porcine iPS cells generated and cultured under various conditions. Telomere lengths vary among different porcine iPS cell lines, some with telomere elongation and maintenance, and others telomere shortening. Porcine iPS cells with sufficient telomere length maintenance show the ability to differentiate in vivo by teratoma formation test. IPS cells with short or dysfunctional telomeres exhibit reduced ability to form teratomas. Moreover, insufficient telomerase and incomplete telomere reprogramming and/or maintenance link to sustained activation of exogenous genes in porcine iPS cells. In contrast, porcine iPS cells with reduced expression of exogenous genes or partial exogene silencing exhibit insufficient activation of endogenous pluripotent genes and telomerase genes, accompanied by telomere shortening with increasing passages. Moreover, telomere doublets, telomere sister chromatid exchanges and t-circles that presumably are involved in telomere lengthening by recombination also are found in porcine iPS cells. These data suggest that both telomerase-dependent and telomerase-independent mechanisms are involved in telomere reprogramming during induction and passages of porcine iPS cells, but these are insufficient, resulting in increased telomere damage and shortening, and chromosomal instability. Active exogenes might compensate for insufficient activation of endogenous genes and incomplete telomere reprogramming and maintenance of porcine iPS cells. Further understanding of telomere reprogramming and maintenance may help improve the quality of porcine iPS cells.

  12. Telomere reprogramming and maintenance in porcine iPS cells.

    Science.gov (United States)

    Ji, Guangzhen; Ruan, Weimin; Liu, Kai; Wang, Fang; Sakellariou, Despoina; Chen, Jijun; Yang, Yang; Okuka, Maja; Han, Jianyong; Liu, Zhonghua; Lai, Liangxue; Gagos, Sarantis; Xiao, Lei; Deng, Hongkui; Li, Ning; Liu, Lin

    2013-01-01

    Telomere reprogramming and silencing of exogenous genes have been demonstrated in mouse and human induced pluripotent stem cells (iPS cells). Pigs have the potential to provide xenotransplant for humans, and to model and test human diseases. We investigated the telomere length and maintenance in porcine iPS cells generated and cultured under various conditions. Telomere lengths vary among different porcine iPS cell lines, some with telomere elongation and maintenance, and others telomere shortening. Porcine iPS cells with sufficient telomere length maintenance show the ability to differentiate in vivo by teratoma formation test. IPS cells with short or dysfunctional telomeres exhibit reduced ability to form teratomas. Moreover, insufficient telomerase and incomplete telomere reprogramming and/or maintenance link to sustained activation of exogenous genes in porcine iPS cells. In contrast, porcine iPS cells with reduced expression of exogenous genes or partial exogene silencing exhibit insufficient activation of endogenous pluripotent genes and telomerase genes, accompanied by telomere shortening with increasing passages. Moreover, telomere doublets, telomere sister chromatid exchanges and t-circles that presumably are involved in telomere lengthening by recombination also are found in porcine iPS cells. These data suggest that both telomerase-dependent and telomerase-independent mechanisms are involved in telomere reprogramming during induction and passages of porcine iPS cells, but these are insufficient, resulting in increased telomere damage and shortening, and chromosomal instability. Active exogenes might compensate for insufficient activation of endogenous genes and incomplete telomere reprogramming and maintenance of porcine iPS cells. Further understanding of telomere reprogramming and maintenance may help improve the quality of porcine iPS cells.

  13. Statistics For Dummies

    CERN Document Server

    Rumsey, Deborah

    2011-01-01

    The fun and easy way to get down to business with statistics Stymied by statistics? No fear ? this friendly guide offers clear, practical explanations of statistical ideas, techniques, formulas, and calculations, with lots of examples that show you how these concepts apply to your everyday life. Statistics For Dummies shows you how to interpret and critique graphs and charts, determine the odds with probability, guesstimate with confidence using confidence intervals, set up and carry out a hypothesis test, compute statistical formulas, and more.Tracks to a typical first semester statistics cou

  14. FTIR spectroscopy supported by statistical techniques for the structural characterization of plastic debris in the marine environment: Application to monitoring studies.

    Science.gov (United States)

    Mecozzi, Mauro; Pietroletti, Marco; Monakhova, Yulia B

    2016-05-15

    We inserted 190 FTIR spectra of plastic samples in a digital database and submitted it to Independent Component Analysis (ICA) to extract the "pure" plastic polymers present. These identified plastics were polypropylene (PP), high density polyethylene (HDPE), low density polyethylene (LDPE), high density polyethylene terephthalate (HDPET), low density polyethylene terephthalate (LDPET), polystyrene (PS), Nylon (NL), polyethylene oxide (OPE), and Teflon (TEF) and they were used to establish the similarity with unknown plastics using the correlation coefficient (r), and the crosscorrelation function (CC). For samples with r<0.8 we determined the Mahalanobis Distance (MD) as additional tool of identification. For instance, for the four plastic fragments found in the Carretta carretta, one plastic sample was assigned to OPE due to its r=0.87; for all the other three plastic samples, due to the r values ranging between 0.83 and0.70, the support of MD suggested LDPET and OPE as co-polymer constituents. Copyright © 2016 Elsevier Ltd. All rights reserved.

  15. High-quality crystalline rubrene thin film on electron-irradiated PS

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Hyeok Moo; Kim, Yong Nam; Kim, Jae Joon; Cho, Sung Oh [Korea Advanced Institute of Science and Technology, Daejeon (Korea, Republic of)

    2011-05-15

    From much of recent works, it was found that charge carrier transport in organic thin film transistors (OTFTs) is strongly affected by the first several semiconductor monolayers next to the semiconductor insulator interface. Among the interfacial factors, insulator surface roughness, surface energy, surface polarity and dielectric constant of dielectrics are considered as important parameters to affect performance of the OTFT. Thus, recently, a lot of efforts to optimize the conditions of surface of dielectrics using various treatment techniques have been performed. Among these techniques, surface modification using polymeric materials is very simple and qualities of polymer surface are hardly affected by preparation conditions. However, surface chain segmental motions near the glass transition temperature disrupts the growth of large-grain morphologies leading low carrier mobility. Thus, there is limitation in temperature to fabricate the organic semiconductor active layer. Here we present a strategy to fabricate high-quality crystalline rubrene thin film using combination of abrupt heating technique and electron irradiation of common homopolymer dielectrics of polystyrene (PS). Electron irradiation induces crosslinking of hydrocarbon chains of PS that restricts chain segmental motion even at the high temperature of 170 .deg. C. Through this method, high quality crystalline rubrene film can be remarkably rapidly produced on PS/SiO{sub 2} bilayer dielectrics in just 1 min

  16. New layered tin(II) thiophosphates ASnPS4 (A = K, Rb, Cs): synthesis, structure, glass formation, and the modulated CsSnPS4.

    Science.gov (United States)

    Banerjee, Santanu; Malliakas, Christos D; Kanatzidis, Mercouri G

    2012-11-05

    The layered compounds KSnPS(4) (1), RbSnPS(4) (2), and CsSnPS(4) (3) were synthesized using the chalcophosphate flux technique at high temperature and are rare examples of divalent Sn(II) thiophosphates. Orange polyhedral crystals of compound 1 crystallize in the monoclinic space group P2(1)/c with a = 6.6673(13) Å, b = 11.9697(24) Å, c = 8.7604(18), and β=127.347(8)° in a 2-dimensional layered structure. Compound 2 is isostructural to 1. Yellow block shaped crystals of compound 3 crystallize in the monoclinic superspace group P2(1)(αβ0)0 with a commensurate q-vector at 1/4a* + 1/4c* with a = 18.0477(14) Å, b = 6.2021(5) Å, and c = 6.8415(5) Å. The structure of all three compounds contains SnS(3) pyramids, which is an extremely rare solid state chalcogenide coordination environment. All three compounds are semiconductors having well-defined band-gaps between 2.0 and 2.2 eV. The compounds are congruently melting and can be obtained as glasses by rapid quenching of the melt, which subsequently crystallize upon heating.

  17. Cancer Statistics

    Science.gov (United States)

    ... What Is Cancer? Cancer Statistics Cancer Disparities Cancer Statistics Cancer has a major impact on society in ... success of efforts to control and manage cancer. Statistics at a Glance: The Burden of Cancer in ...

  18. Caregiving Statistics

    Science.gov (United States)

    ... Coping with Alzheimer’s COPD Caregiving Take Care! Caregiver Statistics Statistics on Family Caregivers and Family Caregiving Caregiving Population ... Health Care Caregiver Self-Awareness State by State Statistics Caregiving Population The value of the services family ...

  19. Trace2PS and FSA2PS: two software toolkits for converting trace and fsa files to PostScript format

    Directory of Open Access Journals (Sweden)

    Werber Martin

    2009-07-01

    Full Text Available Abstract Background Due to the advanced techniques in sequencing and fragment analysis, DNA sequencers and analyzers produce vast amounts of data within short time. To administrate the large data volume conveniently, efficient data management systems are used in order to process and to store sequencers' or analyzers' data outcome. The inclusion of graphical reports in such systems is necessary to achieve a comprehensive view of the integrated data. However, the resulting data of sequencing and fragment analysis runs are stored in a proprietary format, the so-called trace or fsa format, which is only readable by programs provided by the instrument's vendor operating on the machine itself or by commercial tools designed for editing the respective data. To allow for a quick conversion of the proprietary data format into a commonly used one, toolkits are required that reach this aim and can be easily integrated into workflow systems. Results We have developed the software toolkits Trace2PS and Fsa2PS which allow to convert sequence and fragment analysis raw data files to PostScript images, respectively. The toolkits are implemented as Perl modules that can be used as standalone command line applications in conjunction with a script-based analysis pipeline, or integrated in software applications for displaying the data content of trace and fsa files. The converter modules support the commonly used file formats for storage of sequencing (ABI and SCF and fragment analysis data (FSA. Conclusion The software toolkits provide useful applications to convert sequencing and fragment analysis files from a proprietary into a more common, human-readable format. Trace2PS and FSA2PS are useful and capable in data management workflow systems like SAMS, or laboratory information systems that are used for displaying trace and fragment analysis results via web-based tools over an intranet or internet connection to users that can view their results directly on the

  20. DIDIA, BC; GBIGBI, PS; DAPPER, DV*. l

    African Journals Online (AJOL)

    Department of Anatomy and Human Physiology ", College of Health Sciences, University ofPori Harcourt, P.M.B. 5323, Port Harcourt. I Nigeria. ' ABSTRACTS ... The drug/physiological saline was given in three doses at six hourly intervals. .... statistical analysis using analysis of variance; means and standard deviations ...

  1. Shallow PS-logging by high frequency wave; Koshuha wo mochiita senbu PS kenso

    Energy Technology Data Exchange (ETDEWEB)

    Nakajima, A.; Miyazawa, M.; Azuma, H. [OYO Corp., Tokyo (Japan)

    1996-05-01

    This paper describes the following matters on down-hole PS logging in shallow subsurface. Determining an elastic wave velocity structure in shallow subsurface with high accuracy by using down-hole PS logging requires reduction of errors in reading travel time. Therefore, a high-frequency vibration source was fabricated with an objective to raise frequencies of waves used for the measurement. Measurements were made on two holes, A and B, at a measurement interval of 0.5 m, whereas at the hole A a measurement was performed simultaneously by using a normal type (low-frequency) vibration source. A spectral analysis on the waveform record revealed that the frequencies with each vibration source were 127 Hz and 27 Hz for the hole A, 115 Hz for the hole B, and the S/N ratio was all the same for both holes. When the high-frequency vibration source was used, the velocity was determined at accuracy of 5% over the whole length of the shallow section. When the low-frequency vibration source was used, sections with the velocity determining error greater than 5% were found, and it was not possible to derive the velocity structure in the shallow subsurface in fine segments. 3 refs., 8 figs., 2 tabs.

  2. Validation of the OMERACT Psoriatic Arthritis Magnetic Resonance Imaging Score (PsAMRIS) for the Hand and Foot in a Randomized Placebo-controlled Trial

    DEFF Research Database (Denmark)

    Glinatsi, Daniel; Bird, Paul; Gandjbakhch, Frederique

    2015-01-01

    Objective. To assess changes following treatment and the reliability and responsiveness to change of the Outcome Measures in Rheumatology (OMERACT) Psoriatic Arthritis Magnetic Resonance Imaging Score (PsAMRIS) in a randomized controlled trial. Methods. Forty patients with PsA randomized to either......). Results. Inflammatory features improved numerically but statistically nonsignificantly in the ABA group but not the placebo group. Baseline intrareader intraclass correlation coefficients (ICC) were good (≥ 0.50) to very good (≥ 0.80) for all features in both hand and foot. Baseline interreader ICC were......AMRIS may be a valid tool for MRI assessment of hands and feet in PsA clinical trials....

  3. Statistical Pattern Recognition

    CERN Document Server

    Webb, Andrew R

    2011-01-01

    Statistical pattern recognition relates to the use of statistical techniques for analysing data measurements in order to extract information and make justified decisions.  It is a very active area of study and research, which has seen many advances in recent years. Applications such as data mining, web searching, multimedia data retrieval, face recognition, and cursive handwriting recognition, all require robust and efficient pattern recognition techniques. This third edition provides an introduction to statistical pattern theory and techniques, with material drawn from a wide range of fields,

  4. Overview of the Moral Status of iPS Cells.

    Science.gov (United States)

    Martinho, Andreia Martins

    2016-07-01

    The production of induced pluripotent stem (iPS) cells in 2006 by Takahashi and Yamanaka was a major breakthrough in stem cell research. IPS cells technology holds great promise for cell therapy, disease modelling, and drug testing, but it poses ethical questions concerning the moral status of somatic cells, which can re-gain pluripotency (iPS cells). This article provides an overview of the arguments that substantiate the debate on the moral assessment of iPS cells: potentiality argument; relational properties/standard view; and genetic basis for moral status.

  5. Psoriatic arthritis: imaging techniques

    Directory of Open Access Journals (Sweden)

    E. Lubrano

    2012-06-01

    Full Text Available Imaging techniques to assess psoriatic arthritis (PsA include radiography, ultrasonography (US, magnetic resonance imaging (MRI, computed tomography (CT and bone scintigraphy. The radiographic hallmark of PsA is the combination of destructive changes (joint erosions, tuft resorption, osteolysis with bone proliferation (including periarticular and shaft periostitis, ankylosis, spur formation and non-marginal syndesmophytes. US has an increasing important role in the evaluation of PsA. In fact, power Doppler US is useful mainly for its ability to assess musculoskeletal (joints, tendons, entheses and cutaneous (skin and nails involvement, to monitor efficacy of therapy and to guide steroid injections at the level of inflamed joints, tendon sheaths and entheses. MRI allows direct visualization of inflammation in peripheral and axial joints, and peripheral and axial entheses, and has dramatically improved the possibilities for early diagnosis and objective monitoring of the disease process in PsA. MRI has allowed explaining the relationships among enthesitis, synovitis and osteitis in PsA, supporting a SpA pattern of inflammation where enthesitis is the primary target of inflammation. CT has little role in assessment of peripheral joints, but it may be useful in assessing elements of spine disease. CT accuracy is similar to MRI in assessment of erosions in sacroiliac joint involvement, but CT is not as effective in detecting synovial inflammation. Bone scintigraphy lacks specificity and is now supplanted with US and MRI techniques.

  6. Business statistics for dummies

    CERN Document Server

    Anderson, Alan

    2013-01-01

    Score higher in your business statistics course? Easy. Business statistics is a common course for business majors and MBA candidates. It examines common data sets and the proper way to use such information when conducting research and producing informational reports such as profit and loss statements, customer satisfaction surveys, and peer comparisons. Business Statistics For Dummies tracks to a typical business statistics course offered at the undergraduate and graduate levels and provides clear, practical explanations of business statistical ideas, techniques, formulas, and calculations, w

  7. Statistics in a nutshell

    CERN Document Server

    Boslaugh, Sarah

    2013-01-01

    Need to learn statistics for your job? Want help passing a statistics course? Statistics in a Nutshell is a clear and concise introduction and reference for anyone new to the subject. Thoroughly revised and expanded, this edition helps you gain a solid understanding of statistics without the numbing complexity of many college texts. Each chapter presents easy-to-follow descriptions, along with graphics, formulas, solved examples, and hands-on exercises. If you want to perform common statistical analyses and learn a wide range of techniques without getting in over your head, this is your book.

  8. PS buildings : reinforced concrete structure for shielding "bridge" pillar

    CERN Multimedia

    CERN PhotoLab

    1956-01-01

    The PS ring traverses the region between the experimental halls South and North (buildings Nos 150 and 151) under massive bridge-shaped concrete beams. This pillar stands at the S-W end of the structure.

  9. New safety training for access to the PS complex areas

    CERN Multimedia

    2012-01-01

    Since 10/08/2012, a new course dedicated to the specific radiological risks in the accelerators of the PS complex has been available on SIR (https://sir.cern.ch/). This course complements the general classroom-based Radiation Safety training. Successful completion of the course will be obligatory and verified by the access system as from 01/11/2012 for access to the following accelerator areas: LINAC2, BOOSTER, PS and TT2. Information and reminder e-mails will be sent to all persons currently authorized to access the accelerators of the PS complex. For questions please contact the HSE unit and in particular, the Radiation Protection Group (+41227672504 or safety-rp-ps-complex@cern.ch).

  10. Study of Value Co-Creation in CoPS

    OpenAIRE

    Mingli Zhang; Jianhua Ye

    2013-01-01

    Value co-creation is associated with specific investment in the context of CoPS. The feature of CoPS decides that the study of co-creation cannot execute without regarding asset specificity. This study considers that value co-creation will be associated with specific value, which is outcome of relationship value and asset specificity. Supplier and customer have a close relation, which conducts to specific investment and then it turns to obstacle for competitors. Trust, commitment and satisfac...

  11. Motor-generator set of the PS main supply

    CERN Multimedia

    Photographic Service; CERN PhotoLab

    1968-01-01

    Already in 1964, the PS improvement programme included a new main magnet supply with more power for the longer cycles needed for slow extraction at the full energy of 26 GeV. This motor-generator set was installed in 1967 and took up service at the beginning of 1968. Regularly serviced and fitted with modern electronic regulation, it pulses the PS to this day.

  12. The Libera as a PS orbit measurement system building block

    CERN Document Server

    Belleman, J M; CERN. Geneva. AB Department

    2005-01-01

    During the year 2004, extensive tests using a Libera data processor have been made in order to study its suitability as a building block for a complete PS trajectory and orbit measurement system. The Libera consists of four fast 12-bits ADCs, a Virtex II Pro FPGA and a large memory. This note presents some of the results of the analysis of acquisitions made on a position pick-up in the CERN PS.

  13. DiPS: A Unifying Approach for developing System Software

    OpenAIRE

    Michiels, Sam; Matthijs, Frank; Walravens, Dirk; Verbaeten, Pierre

    2002-01-01

    In this paper we unify three essential features for flexible system software: a component oriented approach, self-adaptation and separation of concerns.We propose DiPS (Distrinet Protocol Stack), a component framework, which offers components, an anonymous interaction model and connectors to handle non-functional aspects such as concurrency. DiPS has effectively been used in industrial protocol stacks and device drivers.

  14. The new heart of the PS is beating strongly

    CERN Document Server

    Corinne Pralavorio

    2011-01-01

    The PS has resumed operation with a brand new electrical power system called POPS; this enormous system comprising power electronics and capacitors is crucial because if it broke down practically no particles would be able to circulate at CERN. As soon as it started, POPS passed all the tests with flying colours and is now pulsing at full power.   The new PS power system is made up of 6 containers, each with 60 tonnes of capacitors and 8 power converters. The date 11/02/11 will always be remembered with affection by the engineers in the Electrical Power Converters Group. At 11:11 in the morning (no joke), the first beams powered by the new system began to circulate in the PS. The cutely-named POPS (POwer for PS) took over from the old rotating machine that had been working since 1968. From now on it will be POPS that supplies the PS main magnets with the electrical pulses needed to accelerate the beams for the LHC and all CERN's other facilities. The system is crucial as the PS is one of the lyn...

  15. The PS will soon be back in operation

    CERN Multimedia

    2006-01-01

    The PS's power supply system is undergoing repairs for the accelerator to restart on 26 June. The AB Department's Power Converter Group is working flat out with Siemens to return the PS's power supply system to working order. A problem appeared on the insulation of the power cables of the rotor of the rotating machine (photo) which supplies power to the PS magnets. To prevent more significant damage to the rotating machine, the AB Department, with the approval of the CERN Management, decided to shut down the PS which had started running on 15 May. Everything is being done to restart the accelerator on 26 June. The PS's rotating machine comprises a motor coupled to a generator. The generator's rotor acts like a flywheel, supplying high-power pulses of 40 to 50 megawatts to the PS magnets. The 6 megawatt motor drives the installation at 1000 revolutions per minute and compensates only for variations in speed. It is an essential interface since it would be hard to imagine connecting such an electrical charge, p...

  16. Reduction of Complications of Local Anaesthesia in Dental Healthcare Setups by Application of the Six Sigma Methodology: A Statistical Quality Improvement Technique.

    Science.gov (United States)

    Akifuddin, Syed; Khatoon, Farheen

    2015-12-01

    Health care faces challenges due to complications, inefficiencies and other concerns that threaten the safety of patients. The purpose of his study was to identify causes of complications encountered after administration of local anaesthesia for dental and oral surgical procedures and to reduce the incidence of complications by introduction of six sigma methodology. DMAIC (Define, Measure, Analyse, Improve and Control) process of Six Sigma was taken into consideration to reduce the incidence of complications encountered after administration of local anaesthesia injections for dental and oral surgical procedures using failure mode and effect analysis. Pareto analysis was taken into consideration to analyse the most recurring complications. Paired z-sample test using Minitab Statistical Inference and Fisher's exact test was used to statistically analyse the obtained data. The p-value six sigma improvement methodology in healthcare tends to deliver consistently better results to the patients as well as hospitals and results in better patient compliance as well as satisfaction.

  17. Simulation of a wide area survey for NEOs with Pan-STARRS PS1 & PS2 Telescopes

    Science.gov (United States)

    Chambers, Kenneth C.; Lilly (Schunova), Eva; Dukes, Martin Todd; Wainscoat, Richard J.

    2017-10-01

    We have performed a new survey simulation for a wide area survey with PS1 & PS2 as part of our quest to optimize the discovery rate of Near Earth Objects with the full Pan-STARRS system. The survey is intended to be as unbiased and as complete as possible given the available sky visibility and the anticipated performance of the PS1 and PS2 telescopes working together. The simulation includes a complete model of both telescopes, camera and slew overhead, sky visibility, moon phase, galactic plane exclusion, and weather. The performance of the resulting survey strategy is then evaluated using the method of Lilly et. al. 2017. This uses the Greenstreet et al. 2012 model with 50 million NEOs with absolute magnitudes 13 < H < 29 and the Moving Object Processing System (MOPS, Denneau et al. 2013) for linkages. The results are compared with other possible strategies.

  18. Descriptive statistics.

    Science.gov (United States)

    Shi, Runhua; McLarty, Jerry W

    2009-10-01

    In this article, we introduced basic concepts of statistics, type of distributions, and descriptive statistics. A few examples were also provided. The basic concepts presented herein are only a fraction of the concepts related to descriptive statistics. Also, there are many commonly used distributions not presented herein, such as Poisson distributions for rare events and exponential distributions, F distributions, and logistic distributions. More information can be found in many statistics books and publications.

  19. Vector-free and transgene-free human iPS cells differentiate into functional neurons and enhance functional recovery after ischemic stroke in mice.

    Directory of Open Access Journals (Sweden)

    Osama Mohamad

    Full Text Available Stroke is a leading cause of human death and disability in the adult population in the United States and around the world. While stroke treatment is limited, stem cell transplantation has emerged as a promising regenerative therapy to replace or repair damaged tissues and enhance functional recovery after stroke. Recently, the creation of induced pluripotent stem (iPS cells through reprogramming of somatic cells has revolutionized cell therapy by providing an unlimited source of autologous cells for transplantation. In addition, the creation of vector-free and transgene-free human iPS (hiPS cells provides a new generation of stem cells with a reduced risk of tumor formation that was associated with the random integration of viral vectors seen with previous techniques. However, the potential use of these cells in the treatment of ischemic stroke has not been explored. In the present investigation, we examined the neuronal differentiation of vector-free and transgene-free hiPS cells and the transplantation of hiPS cell-derived neural progenitor cells (hiPS-NPCs in an ischemic stroke model in mice. Vector-free hiPS cells were maintained in feeder-free and serum-free conditions and differentiated into functional neurons in vitro using a newly developed differentiation protocol. Twenty eight days after transplantation in stroke mice, hiPS-NPCs showed mature neuronal markers in vivo. No tumor formation was seen up to 12 months after transplantation. Transplantation of hiPS-NPCs restored neurovascular coupling, increased trophic support and promoted behavioral recovery after stroke. These data suggest that using vector-free and transgene-free hiPS cells in stem cell therapy are safe and efficacious in enhancing recovery after focal ischemic stroke in mice.

  20. Investigation of non-linear optical properties of CdS/PS polymer nanocomposite synthesized by chemical route

    Science.gov (United States)

    Tripathi, S. K.; Kaur, Ramneek; Jyoti

    2015-10-01

    Cadmium Sulfide (CdS) nanoparticles play an important role in non-linear optoelectronic devices. CdS/Polystyrene(PS) nanocomposite has been prepared by chemical ex-situ route and characterized by X-Ray Diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR), Ultraviolet-visible (UV-vis) and Photoluminescence (PL) spectroscopy. XRD spectra of CdS/PS nanocomposite reveals the cubic phase of CdS nanoparticles with average crystallite size ~2.54 nm. The vibrational band corresponding to Cd-S bond has been observed at 406.57 cm-1 in FTIR spectra of CdS/PS nanocomposite along the typical styrene bonds. Quantum confinement effect in the CdS/PS nanocomposite has been confirmed from the UV-vis spectra. In PL emission spectra, in addition to band to band transition emission, the green and yellow bands have been observed due to the interstitial sulfur and cadmium defect states respectively. Z-scan technique has been utilized to study the non-linear optical properties of the CdS/PS nanocomposite. The value of non-linear absorption coefficient (β) and non-linear refractive index (n2) has been calculated. The large value of third order non-linear susceptibility is due to the quantum confinement effect plus the thermal lensing effect produced across the sample.

  1. Estimation and inferential statistics

    CERN Document Server

    Sahu, Pradip Kumar; Das, Ajit Kumar

    2015-01-01

    This book focuses on the meaning of statistical inference and estimation. Statistical inference is concerned with the problems of estimation of population parameters and testing hypotheses. Primarily aimed at undergraduate and postgraduate students of statistics, the book is also useful to professionals and researchers in statistical, medical, social and other disciplines. It discusses current methodological techniques used in statistics and related interdisciplinary areas. Every concept is supported with relevant research examples to help readers to find the most suitable application. Statistical tools have been presented by using real-life examples, removing the “fear factor” usually associated with this complex subject. The book will help readers to discover diverse perspectives of statistical theory followed by relevant worked-out examples. Keeping in mind the needs of readers, as well as constantly changing scenarios, the material is presented in an easy-to-understand form.

  2. Lectures on algebraic statistics

    CERN Document Server

    Drton, Mathias; Sullivant, Seth

    2009-01-01

    How does an algebraic geometer studying secant varieties further the understanding of hypothesis tests in statistics? Why would a statistician working on factor analysis raise open problems about determinantal varieties? Connections of this type are at the heart of the new field of "algebraic statistics". In this field, mathematicians and statisticians come together to solve statistical inference problems using concepts from algebraic geometry as well as related computational and combinatorial techniques. The goal of these lectures is to introduce newcomers from the different camps to algebraic statistics. The introduction will be centered around the following three observations: many important statistical models correspond to algebraic or semi-algebraic sets of parameters; the geometry of these parameter spaces determines the behaviour of widely used statistical inference procedures; computational algebraic geometry can be used to study parameter spaces and other features of statistical models.

  3. Experimental Mathematics and Computational Statistics

    Energy Technology Data Exchange (ETDEWEB)

    Bailey, David H.; Borwein, Jonathan M.

    2009-04-30

    The field of statistics has long been noted for techniques to detect patterns and regularities in numerical data. In this article we explore connections between statistics and the emerging field of 'experimental mathematics'. These includes both applications of experimental mathematics in statistics, as well as statistical methods applied to computational mathematics.

  4. PP and PS joint inversion with a posterior constraint and with particle filtering

    Science.gov (United States)

    Tang, Jing; Wang, Yanfei

    2017-12-01

    The Bayesian framework works well in amplitude versus offset (AVO) inversion, which merges multi-information together to generate posterior distributions of P-wave velocity, S-wave velocity and density. Most existing AVO inversion methods utilize PP reflection seismic data to predict the three elastic parameters. These methods are not usually sensitive to S-wave velocity and density, which make the inversion methods inaccurate and unstable. One way of solving these problems is to perform PP and PS joint inversion by incorporating PS seismic data. Another way is to provide a relatively accurate prior model. In this paper, we apply a particle filtering technique to produce a prior model for the PP and PS joint inversion. In the Bayesian inversion setting, the prior model works as the regularization term. Particle filtering is a Bayesian recursive method that combines prior information with observed data to provide a posterior constraint to reduce the joint inversion’s uncertainty. We generate synthetic models with different signal-to-noise ratios to validate our new method. Comparisons are provided with the traditional joint inversion, which adopts the Gaussian prior model. The inversion results show that the three elastic parameters are retrieved well when the signal-to-noise ratios are high. As the signal-to-noise ratio reduces, our new method can depict more detailed changes than the traditional inversion method, and improves the inversion accuracy apparent in the target layers.

  5. Characterization of crosslinked polystyrene(PS) beads in SBR matrix

    Energy Technology Data Exchange (ETDEWEB)

    Cha, Yoon-Jong; Choe, Soonja [Inha Univ. (Korea, Republic of)

    1995-12-01

    Monodisperse sized crosslinked polystyrene(PS) beads were prepared by a reaction of semibatch emulsion polymerization with styrene monomer, divinylbenzene(DVB) crosslinking agent and potassium persulfate(K{sub 2}S{sub 2}O{sub 9}) initiator in the absence of emulsifier. The glass transition temperature(T{sub g}) and the mean diameter of the beads were increased from 100{degrees}C to 135{degrees}C and from 402 nm to 532 nm, respectively, for an incorporation of 2 to 10 mol% DVB. Crosslinking density was also linearly increased with DVB content. SEM microphotographs of SBR composite filled with various contents of PS beads revealed that PS beads are relatively well dispersed without changing the spherical shape of the beads in all range of compositions. In stress-strain analysis, elongation at break and tensile strength of SBR composite were increased with the bead content. Applicability of the PS beads as a filler in SBR matrix is tested by plotting Mooney-Rivlin or Guth-Smallwood equations. However, mechanical properties of the composite with the beads were not so excellent as those of the composite with carbon black. Crosslinked PS beads are still tentative as a white color reinforcing filler on SBR matrix.

  6. The PS complex produces the nominal LHC beam

    CERN Document Server

    Benedikt, Michael; Borburgh, J; Cappi, R; Chanel, M; Chohan, V; Cyvoct, G; Garoby, R; Grier, D G; Gruber, J; Hancock, S; Hill, C E; Jensen, E; Krusche, A; Lindroos, M; Métral, Elias; Métral, G; Metzmacher, K D; Olsfors, J; Pedersen, F; Raich, U; Riunaud, J P; Royer, J P; Sassowsky, M; Schindl, Karlheinz; Schönauer, Horst Otto; Thivent, M; Ullrich, H M; Völker, F V; Vretenar, Maurizio; Barnes, M; Blackmore, E W; Cifarelli, F; Clark, G; Jones, F; Koscielniak, Shane Rupert; Mammarella, F; Mitra, A; Poirier, R; Reiniger, K W; Ries, T C

    2000-01-01

    The LHC [1] will be supplied, via the SPS, with protons from the pre-injector chain comprising Linac2, PS Booster (PSB) and PS. These accelerators have under-gone a major upgrading programme [2] during the last five years so as to meet the stringent requirements of the LHC. These imply that many high-intensity bunches of small emittance and tight spacing (25 ns) be available at the PS extraction energy (25 GeV). The upgrading project involved an increase of Linac2 current, new RF systems in the PSB and the PS, raising the PSB energy from 1 to 1.4 GeV, two-batch filling of the PS and the installation of high-resolution beam profile measurement devices. With the project entering its final phase and most of the newly installed hardware now being operational, the emphasis switches to producing the nominal LHC beam and tackling the associated beam physics problems. While a beam with transverse characteristics better than nominal has been obtained, the longitudinal density still needs to be increased. An alternativ...

  7. Pressure Monitoring Using Hybrid fs/ps Rotational CARS

    Science.gov (United States)

    Kearney, Sean P.; Danehy, Paul M.

    2015-01-01

    We investigate the feasibility of gas-phase pressure measurements at kHz-rates using fs/ps rotational CARS. Femtosecond pump and Stokes pulses impulsively prepare a rotational Raman coherence, which is then probed by a high-energy 6-ps pulse introduced at a time delay from the Raman preparation. Rotational CARS spectra were recorded in N2 contained in a room-temperature gas cell for pressures from 0.1 to 3 atm and probe delays ranging from 10-330 ps. Using published self-broadened collisional linewidth data for N2, both the spectrally integrated coherence decay rate and the spectrally resolved decay were investigated as means for detecting pressure. Shot-averaged and single-laser-shot spectra were interrogated for pressure and the accuracy and precision as a function of probe delay and cell pressure are discussed. Single-shot measurement accuracies were within 0.1 to 6.5% when compared to a transducer values, while the precision was generally between 1% and 6% of measured pressure for probe delays of 200 ps or more, and better than 2% as the delay approached 300 ps. A byproduct of the pressure measurement is an independent but simultaneous measurement of the gas temperature.

  8. A study of trace element contamination using multivariate statistical techniques and health risk assessment in groundwater of Chhaprola Industrial Area, Gautam Buddha Nagar, Uttar Pradesh, India.

    Science.gov (United States)

    Kumar, Manoj; Ramanathan, A L; Tripathi, Ritu; Farswan, Sandhya; Kumar, Devendra; Bhattacharya, Prosun

    2017-01-01

    This study is an investigation on spatio-chemical, contamination sources (using multivariate statistics), and health risk assessment arising from the consumption of groundwater contaminated with trace and toxic elements in the Chhaprola Industrial Area, Gautam Buddha Nagar, Uttar Pradesh, India. In this study 33 tubewell water samples were analyzed for 28 elements using ICP-OES. Concentration of some trace and toxic elements such as Al, As, B, Cd, Cr, Mn, Pb and U exceeded their corresponding WHO (2011) guidelines and BIS (2012) standards while the other analyzed elements remain below than those values. Background γ and β radiation levels were observed and found to be within their acceptable limits. Multivariate statistics PCA (explains 82.07 cumulative percent for total 6 of factors) and CA indicated (mixed origin) that natural and anthropogenic activities like industrial effluent and agricultural runoff are responsible for the degrading of groundwater quality in the research area. In this study area, an adult consumes 3.0 L (median value) of water therefore consuming 39, 1.94, 1461, 0.14, 11.1, 292.6, 13.6, 23.5 μg of Al, As, B, Cd, Cr, Mn, Pb and U from drinking water per day respectively. The hazard quotient (HQ) value exceeded the safe limit of 1 which for As, B, Al, Cr, Mn, Cd, Pb and U at few locations while hazard index (HI) > 5 was observed in about 30% of the samples which indicated potential health risk from these tubewells for the local population if the groundwater is consumed. Copyright © 2016 Elsevier Ltd. All rights reserved.

  9. Radiation dose reduction with the adaptive statistical iterative reconstruction (ASIR) technique for chest CT in children: An intra-individual comparison

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Seung Hyun, E-mail: circle1128@yuhs.ac [Department of Radiology and Research Institute of Radiological Science, Severance Children' s Hospital, Yonsei University, College of Medicine, Seoul (Korea, Republic of); Kim, Myung-Joon, E-mail: mjkim@yuhs.ac [Department of Radiology and Research Institute of Radiological Science, Severance Children' s Hospital, Yonsei University, College of Medicine, Seoul (Korea, Republic of); Yoon, Choon-Sik, E-mail: yooncs58@yuhs.ac [Department of Radiology, Gangnam Severance Hospital, Yonsei University, College of Medicine, Seoul (Korea, Republic of); Lee, Mi-Jung, E-mail: mjl1213@yuhs.ac [Department of Radiology and Research Institute of Radiological Science, Severance Children' s Hospital, Yonsei University, College of Medicine, Seoul (Korea, Republic of)

    2012-09-15

    Objective: To retrospectively compare radiation dose and image quality of pediatric chest CT using a routine dose protocol reconstructed with filtered back projection (FBP) (the Routine study) and a low-dose protocol with 50% adaptive statistical iterative reconstruction (ASIR) (the ASIR study). Materials and methods: We retrospectively reviewed chest CT performed in pediatric patients who underwent both the Routine study and the ASIR study on different days between January 2010 and August 2011. Volume CT dose indices (CTDIvol), dose length products (DLP), and effective doses were obtained to estimate radiation dose. The image quality was evaluated objectively as noise measured in the descending aorta and paraspinal muscle, and subjectively by three radiologists for noise, sharpness, artifacts, and diagnostic acceptability using a four-point scale. The paired Student's t-test and the Wilcoxon signed-rank test were used for statistical analysis. Results: Twenty-six patients (M:F = 13:13, mean age 11.7) were enrolled. The ASIR studies showed 60.3%, 56.2%, and 55.2% reductions in CTDIvol (from 18.73 to 7.43 mGy, P < 0.001), DLP (from 307.42 to 134.51 mGy × cm, P < 0.001), and effective dose (from 4.12 to 1.84 mSv, P < 0.001), respectively, compared with the Routine studies. The objective noise was higher in the paraspinal muscle of the ASIR studies (20.81 vs. 16.67, P = 0.004), but was not different in the aorta (18.23 vs. 18.72, P = 0.726). The subjective image quality demonstrated no difference between the two studies. Conclusion: A low-dose protocol with 50% ASIR allows radiation dose reduction in pediatric chest CT by more than 55% while maintaining image quality.

  10. Radiation dose reduction with the adaptive statistical iterative reconstruction (ASIR) technique for chest CT in children: an intra-individual comparison.

    Science.gov (United States)

    Lee, Seung Hyun; Kim, Myung-Joon; Yoon, Choon-Sik; Lee, Mi-Jung

    2012-09-01

    To retrospectively compare radiation dose and image quality of pediatric chest CT using a routine dose protocol reconstructed with filtered back projection (FBP) (the Routine study) and a low-dose protocol with 50% adaptive statistical iterative reconstruction (ASIR) (the ASIR study). We retrospectively reviewed chest CT performed in pediatric patients who underwent both the Routine study and the ASIR study on different days between January 2010 and August 2011. Volume CT dose indices (CTDIvol), dose length products (DLP), and effective doses were obtained to estimate radiation dose. The image quality was evaluated objectively as noise measured in the descending aorta and paraspinal muscle, and subjectively by three radiologists for noise, sharpness, artifacts, and diagnostic acceptability using a four-point scale. The paired Student's t-test and the Wilcoxon signed-rank test were used for statistical analysis. Twenty-six patients (M:F=13:13, mean age 11.7) were enrolled. The ASIR studies showed 60.3%, 56.2%, and 55.2% reductions in CTDIvol (from 18.73 to 7.43 mGy, PASIR studies (20.81 vs. 16.67, P=0.004), but was not different in the aorta (18.23 vs. 18.72, P=0.726). The subjective image quality demonstrated no difference between the two studies. A low-dose protocol with 50% ASIR allows radiation dose reduction in pediatric chest CT by more than 55% while maintaining image quality. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

  11. Applied statistical inference with MINITAB

    CERN Document Server

    Lesik, Sally

    2009-01-01

    Through clear, step-by-step mathematical calculations, Applied Statistical Inference with MINITAB enables students to gain a solid understanding of how to apply statistical techniques using a statistical software program. It focuses on the concepts of confidence intervals, hypothesis testing, validating model assumptions, and power analysis.Illustrates the techniques and methods using MINITABAfter introducing some common terminology, the author explains how to create simple graphs using MINITAB and how to calculate descriptive statistics using both traditional hand computations and MINITAB. Sh

  12. Performance of the digene LQ, RH and PS HPVs genotyping systems on clinical samples and comparison with HC2 and PCR-based Linear Array

    Directory of Open Access Journals (Sweden)

    Godínez Jose M

    2011-11-01

    Full Text Available Abstract Background Certain Human Papillomaviruses (HPVs are the infectious agents involved in cervical cancer development. Detection of HPVs DNA is part of the cervical cancer screening protocols and HPVs genotyping has been proposed for its inclusion in these preventive programs. The aim of this study was to evaluate three novel genotyping tests, namely Qiagen LQ, RH and PS, in clinical samples with and without abnormalities. For this, 305 cervical samples were processed and the results of the evaluated techniques were compared with those obtained in the HPVs diagnostic process in our lab, by using HC2 and Linear Array (LA technologies. Results The concordances and kappa statistics (k for each technique compared with HC2 were 98.69% (k = 0.94 for LQ, 98.03% (k = 0.91 for RH and 91.80% (k = 0.82 for PS. There was a very good agreement in HPVs type-specific concordance for the most prevalent types HPV16 (kappa range = 0.83-0.90, HPV18 (k.r.= 0.74-0.80 and HPV45 (k.r.= 0.82-0.90. Conclusions The three tests showed an overall good concordance for HPVs detection when compared with HR-HC2 system. LQ and RH rendered lower detection rate for multiple infections than LA genotyping. However, our understanding of the clinical significance of multiple HPVs infections is still incomplete and therefore the relevance of the lower ability to detect multiple infections needs to be evaluated.

  13. Statistical physics

    CERN Document Server

    Sadovskii, Michael V

    2012-01-01

    This volume provides a compact presentation of modern statistical physics at an advanced level. Beginning with questions on the foundations of statistical mechanics all important aspects of statistical physics are included, such as applications to ideal gases, the theory of quantum liquids and superconductivity and the modern theory of critical phenomena. Beyond that attention is given to new approaches, such as quantum field theory methods and non-equilibrium problems.

  14. Harmonic statistics

    Energy Technology Data Exchange (ETDEWEB)

    Eliazar, Iddo, E-mail: eliazar@post.tau.ac.il

    2017-05-15

    The exponential, the normal, and the Poisson statistical laws are of major importance due to their universality. Harmonic statistics are as universal as the three aforementioned laws, but yet they fall short in their ‘public relations’ for the following reason: the full scope of harmonic statistics cannot be described in terms of a statistical law. In this paper we describe harmonic statistics, in their full scope, via an object termed harmonic Poisson process: a Poisson process, over the positive half-line, with a harmonic intensity. The paper reviews the harmonic Poisson process, investigates its properties, and presents the connections of this object to an assortment of topics: uniform statistics, scale invariance, random multiplicative perturbations, Pareto and inverse-Pareto statistics, exponential growth and exponential decay, power-law renormalization, convergence and domains of attraction, the Langevin equation, diffusions, Benford’s law, and 1/f noise. - Highlights: • Harmonic statistics are described and reviewed in detail. • Connections to various statistical laws are established. • Connections to perturbation, renormalization and dynamics are established.

  15. Statistical distributions

    CERN Document Server

    Forbes, Catherine; Hastings, Nicholas; Peacock, Brian J.

    2010-01-01

    A new edition of the trusted guide on commonly used statistical distributions Fully updated to reflect the latest developments on the topic, Statistical Distributions, Fourth Edition continues to serve as an authoritative guide on the application of statistical methods to research across various disciplines. The book provides a concise presentation of popular statistical distributions along with the necessary knowledge for their successful use in data modeling and analysis. Following a basic introduction, forty popular distributions are outlined in individual chapters that are complete with re

  16. Statistical optics

    CERN Document Server

    Goodman, Joseph W

    2015-01-01

    This book discusses statistical methods that are useful for treating problems in modern optics, and the application of these methods to solving a variety of such problems This book covers a variety of statistical problems in optics, including both theory and applications.  The text covers the necessary background in statistics, statistical properties of light waves of various types, the theory of partial coherence and its applications, imaging with partially coherent light, atmospheric degradations of images, and noise limitations in the detection of light. New topics have been introduced i

  17. PS2013 Satellite Workshop on Photosynthetic Light-Harvesting Systems

    Energy Technology Data Exchange (ETDEWEB)

    Niederman, Robert A. [Rutgers Univ., New Brunswick, NJ (United States); Blankenship, Robert E. [Washington Univ., St. Louis, MO (United States); Frank, Harry A. [Univ. of Connecticut, Storrs, CT (United States)

    2015-02-07

    These funds were used for partial support of the PS2013 Satellite Workshop on Photosynthetic Light-Harvesting Systems, that was held on 8-11 August, 2013, at Washington University, St. Louis, MO. This conference, held in conjunction with the 16th International Congress on Photosynthesis/St. Louis, continued a long tradition of light-harvesting satellite conferences that have been held prior to the previous six international photosynthesis congresses. In this Workshop, the basis was explored for the current interest in replacing fossil fuels with energy sources derived form direct solar radiation, coupled with light-driven electron transport in natural photosynthetic systems and how they offer a valuable blueprint for conversion of sunlight to useful energy forms. This was accomplished through sessions on the initial light-harvesting events in the biological conversion of solar energy to chemically stored energy forms, and how these natural photosynthetic processes serve as a guide to the development of robust bio-hybrid and artificial systems for solar energy conversion into both electricity or chemical fuels. Organized similar to a Gordon Research Conference, a lively, informal and collegial setting was established, highlighting the exchange of exciting new data and unpublished results from ongoing studies. A significant amount of time was set aside for open discussion and interactive poster sessions, with a special session devoted to oral presentations by talented students and postdoctoral fellows judged to have the best posters. This area of research has seen exceptionally rapid progress in recent years, with the availability of a number of antenna protein structures at atomic resolution, elucidation of the molecular surface architecture of native photosynthetic membranes by atomic force microscopy and the maturing of ultrafast spectroscopic and molecular biological techniques for the investigation and manipulation of photosynthetic systems. The conferees

  18. Final Results on the CERN PS Electrostatic Septa Consolidation Program

    CERN Document Server

    Borburgh, Jan; Bobbio, Piero; Carlier, Etienne; Hourican, Michael; Masson, Thierry; Müller, Tania; Prost, Antoine; Crescenti, Massimo

    2003-01-01

    The CERN PS electrostatic septum consolidation program is coming to completion after almost 4 years of development. The program was started to fulfil the increased requirements on vacuum performance and the need to reduce the time necessary for maintenance interventions. The new design of septum 31, used for the so-called 'continuous transfer' 5-turn extraction, and the related construction issues will be presented together with the operational experience gained during the PS 2002 run. In addition, the experience of two years of operation with the new generation septum 23, used for a resonant slow extraction, will be briefly discussed. The continued development undertaken since its installation in the PS ring in 2001 will also be described.

  19. A&T Sector Note on the PS transverse feedback

    CERN Document Server

    Coly, Marcel; Blas, Alfred; Sterbini, Guido; CERN. Geneva. ATS Department

    2017-01-01

    In a particle accelerator, several contributions can degrade the beam quality and particularly the beam transverse emittance. In this document we will describe a system used in the CERN Proton Synchrotron (PS) to cope with the injection steering errors and the transverse instabilities: the PS transverse feedback (PS TFB). As time progresses, this system is also being used for other purpose, to increase in a controlled way the beam transverse emittance and to excite the beam for the Multi-Turn-Extraction (MTE). In 2016, it has been successfully used on some operational beams to damp injection oscillations. This allowed to test the reliability of the system for its operational deployment. A piquet service is available in case of problem.

  20. SAFETY: STRICTER CONTROLS IN CONTROLLED AREAS IN THE PS

    CERN Document Server

    G. Daems

    2001-01-01

    The PS accelerators will soon stop for several months. Work will take place in controlled areas in the PS and will involve many people who are not always aware of the risks associated with the work sites. To guarentee the safety of these workers, the following two measures will be applied: everyone working in a controlled zone - Linacs, PSB, and PS machines tunnels, and transfer lines - must wear, visibly, his CERN access card and his film badge. the CERN access card and the film badge will only be issued after following a basic safety course. Regular checks will be carried out during the shutdown. Anyone without these two items on their person will be obliged to leave the area immediately.

  1. Electrophysical properties of PMN-PT-PS-PFN:Li ceramics

    Directory of Open Access Journals (Sweden)

    R. Skulski

    2013-01-01

    Full Text Available We present the technology of obtaining and the electrophysical properties of a multicomponent material 0.61PMN-0.20PT-0.09PS-0.1PFN:Li (PMN-PT-PS-PFN:Li. The addition of PFN into PMN-PT decreases the temperature of final sintering which is very important during technological process (addition of Li decreases electric conductivity of PFN. Addition of PS i.e., PbSnO3 (which is unstable in ceramic form permits to shift the temperature of the maximum of dielectric permittivity. One-step method of obtaining ceramic samples from oxides and carbonates has been used. XRD, microstructure, scanning calorimetry measurements and the main dielectric, ferroelectric and electromechanical properties have been investigated for the obtained samples.

  2. Evaluation of the environmental contamination at an abandoned mining site using multivariate statistical techniques--the Rodalquilar (Southern Spain) mining district.

    Science.gov (United States)

    Bagur, M G; Morales, S; López-Chicano, M

    2009-11-15

    Unsupervised and supervised pattern recognition techniques such as hierarchical cluster analysis, principal component analysis, factor analysis and linear discriminant analysis have been applied to water samples recollected in Rodalquilar mining district (Southern Spain) in order to identify different sources of environmental pollution caused by the abandoned mining industry. The effect of the mining activity on waters was monitored determining the concentration of eleven elements (Mn, Ba, Co, Cu, Zn, As, Cd, Sb, Hg, Au and Pb) by inductively coupled plasma mass spectrometry (ICP-MS). The Box-Cox transformation has been used to transform the data set in normal form in order to minimize the non-normal distribution of the geochemical data. The environmental impact is affected mainly by the mining activity developed in the zone, the acid drainage and finally by the chemical treatment used for the benefit of gold.

  3. Effect of interfaces on the melting of PEO confined in triblock PS-b-PEO-b-PS copolymers.

    Science.gov (United States)

    Beaudoin, E; Phan, T N T; Robinet, M; Denoyel, R; Davidson, P; Bertin, D; Bouchet, R

    2013-08-27

    Block copolymers form nanostructures that have interesting physical properties because they combine, for a single compound, the complementary features brought by each block. However, in order to fully exploit these properties, the physical state of each kind of domain must be precisely controlled. In this work, triblock PS-b-PEO-b-PS copolymers consisting of a central poly(ethylene oxide) (PEO) block covalently bonded to polystyrene (PS) blocks were synthesized by Atom Transfer Radical Polymerization. Their morphology was investigated by X-ray scattering and TEM experiments whereas their thermodynamic behavior was characterized by DSC. A strong decrease of both the melting temperature and the degree of crystallinity of PEO, due to its confinement between the PS domains, was observed and analyzed with a modified Gibbs-Thomson equation, following the approaches used for fluids confined in porous media. The existence of an amorphous bound layer, a few nanometers thick, at the PEO/PS interface, that does not undergo any phase transition in the temperature range investigated, accounts for both the melting temperature depression and the decrease of crystallinity upon confinement. This interfacial layer may significantly affect the mechanical and transport properties of these block copolymers that find applications as solid polymer electrolytes in batteries for example. Moreover, the value obtained for the solid PEO/liquid PEO surface tension is lower than those previously published but is thermodynamically consistent with the surface tensions of polymers at the solid/vapor and liquid/vapor interfaces.

  4. Use of multiresponse statistical techniques to optimize the separation of diosmin, hesperidin, diosmetin and hesperitin in different pharmaceutical preparations by high performance liquid chromatography with UV-DAD.

    Science.gov (United States)

    Sammani, Mohamad Subhi; Clavijo, Sabrina; Portugal, Lindomar; Suárez, Ruth; Seddik, Hassan; Cerdà, Víctor

    2017-05-15

    A new method for the separation and determination of four flavonoids: hesperidin (HES), diosmin (DIO), hesperitin (HTIN), and diosmetin (DTIN) in pure form and pharmaceutical formulations has been developed by using high performance liquid chromatography (HPLC) with UV-DAD detection. Multivariate statistics (2(k) full factorial and Box Behnken Designs) has been used for the multiresponse optimization of the chromatographic separation, which was completed in 22min, and carried out on a symmetry® C18 column (250×3mm; 5µm) as stationary phase. Separation was conducted by gradient elution mode using a mixture of methanol, acetonitrile and water pH: 2.5 (CH3COOH), as mobile phase. Analytes were separated setting the column at 22°C, with a flow rate of 0.58mLmin(-1) and detected at 285nm. Under the optimized conditions, the flavonoids showed retention times of: 8.62, 11.53, 18.55 and 19.94min for HES, DIO, HTIN and DTIN, respectively. Limits of detection and quantification were drugs. Copyright © 2017 Elsevier B.V. All rights reserved.

  5. Modeling and Analysis of Mechanical Properties of Aluminium Alloy (A413 Processed through Squeeze Casting Route Using Artificial Neural Network Model and Statistical Technique

    Directory of Open Access Journals (Sweden)

    R. Soundararajan

    2015-01-01

    Full Text Available Artificial Neural Network (ANN approach was used for predicting and analyzing the mechanical properties of A413 aluminum alloy produced by squeeze casting route. The experiments are carried out with different controlled input variables such as squeeze pressure, die preheating temperature, and melt temperature as per Full Factorial Design (FFD. The accounted absolute process variables produce a casting with pore-free and ideal fine grain dendritic structure resulting in good mechanical properties such as hardness, ultimate tensile strength, and yield strength. As a primary objective, a feed forward back propagation ANN model has been developed with different architectures for ensuring the definiteness of the values. The developed model along with its predicted data was in good agreement with the experimental data, inferring the valuable performance of the optimal model. From the work it was ascertained that, for castings produced by squeeze casting route, the ANN is an alternative method for predicting the mechanical properties and appropriate results can be estimated rather than measured, thereby reducing the testing time and cost. As a secondary objective, quantitative and statistical analysis was performed in order to evaluate the effect of process parameters on the mechanical properties of the castings.

  6. Inauguration of POPS: the new power system of the PS

    CERN Multimedia

    Maximilien Brice

    2010-01-01

    Pictures 03 and 04 : The team from the Electrical Power Converters Group (TE/EPC) is joined by the Director of Accelerators, the heads of the BE, TE and FI departments, CERN managers and Converteam representatives in a group portrait in front of three of the containers that house the capacitor banks of the PS's new power supply system, POPS. Pictures 01, 06 and 07 : Magid-Michel Saikaly, energy and infrastructure director at Converteam, receives a prize from Steve Myers, Director of Accelerators at CERN, for the development and fabrication of the new electrical power system for the PS, called POPS.

  7. The Septa for LEIR Extraction and PS Injection

    CERN Document Server

    Borburgh, J; Masson, T; Prost, A

    2006-01-01

    The Low Energy Ion Ring (LEIR) is part of the CERN LHC injector chain for ions. The LEIR extraction uses a pulsed magnetic septum, clamped around a metallic vacuum chamber. Apart from separating the ultra high vacuum in the LEIR ring from the less good vacuum in the transfer line to the PS this chamber also serves as magnetic screen and retains the septum conductor in place. The PS ion injection septum consists of a pulsed laminated magnet under vacuum, featuring a single-turn water cooled coil and a remote positioning system. The design, the construction and the commissioning of both septa are described.

  8. Using PS-InSAR to detect surface deformation in geothermal areas of West Java in Indonesia

    Science.gov (United States)

    Maghsoudi, Yasser; van der Meer, Freek; Hecker, Christoph; Perissin, Daniele; Saepuloh, Asep

    2018-02-01

    In this paper, the Persistent Scatterer InSAR (PS-InSAR) technique is applied in order to investigate the ground deformation in and around two geothermal areas in West Java, Indonesia. Two time-series of ALOS PALSAR and Sentinel-1A acquisitions, covering the period from 2007 to 2009 and 2015-2016, are analysed. The first case study examines the Wayang Windu geothermal zone where the PS-InSAR analysis provides an overview of the surface deformation around a geothermal reservoir. Uplift is observed around the injection wells in the area. The second example involves the use of the PS-InSAR technique over a more recent geothermal system in Patuha field. Again, a pattern of uplift was observed around the only available injection well in the area. Due to the dense vegetation coverage of the geothermal areas in West Java, the longer wavelength ALOS PALSAR data is provides better results by identifying a larger number of PS points. Additionally, experiments have been carried out to compare the resulting deformation with another example of the fluid migration process i.e. water extraction in Bandung basin. The potential of sentinel-1A and ALOS PALSR data are compared in all the experiments.

  9. Scan Statistics

    CERN Document Server

    Glaz, Joseph

    2009-01-01

    Suitable for graduate students and researchers in applied probability and statistics, as well as for scientists in biology, computer science, pharmaceutical science and medicine, this title brings together a collection of chapters illustrating the depth and diversity of theory, methods and applications in the area of scan statistics.

  10. Practical Statistics

    CERN Document Server

    Lyons, L.

    2016-01-01

    Accelerators and detectors are expensive, both in terms of money and human effort. It is thus important to invest effort in performing a good statistical anal- ysis of the data, in order to extract the best information from it. This series of five lectures deals with practical aspects of statistical issues that arise in typical High Energy Physics analyses.

  11. Flow curve analysis of a Pickering emulsion-polymerized PEDOT:PSS/PS-based electrorheological fluid

    Science.gov (United States)

    Kim, So Hee; Choi, Hyoung Jin; Leong, Yee-Kwong

    2017-11-01

    The steady shear electrorheological (ER) response of poly(3, 4-ethylenedioxythiophene): poly(styrene sulfonate)/polystyrene (PEDOT:PSS/PS) composite particles, which were initially fabricated from Pickering emulsion polymerization, was tested with a 10 vol% ER fluid dispersed in a silicone oil. The model independent shear rate and yield stress obtained from the raw torque-rotational speed data using a Couette type rotational rheometer under an applied electric field strength were then analyzed by Tikhonov regularization, which is the most suitable technique for solving an ill-posed inverse problem. The shear stress-shear rate data also fitted well with the data extracted from the Bingham fluid model.

  12. The impact of 4Ps on Purchase Decision: A case of Apple in Hanoi, Vietnam

    Directory of Open Access Journals (Sweden)

    Bui Trung Thieu

    2016-01-01

    Full Text Available By using quantitative research methods and deductive reasoning, this research paper aims to address the importance of four marketing mix components (4Ps on purchase decisions of customers of Apple Inc., by launching a survey in Hanoi, Vietnam, to generate primary data. The chosen sampling technique is quota sampling and several “quotas” were built. Descriptive analysis and hypothetical analysis (t-test, one-way ANOVA and Regression using SPSS 20.0 are applied. Other implications of the research and limitations were also discussed below.

  13. Magnetic structure of the quasi-two-dimensional antiferromagnet NiPS3

    Science.gov (United States)

    Wildes, A. R.; Simonet, V.; Ressouche, E.; McIntyre, G. J.; Avdeev, M.; Suard, E.; Kimber, S. A. J.; Lançon, D.; Pepe, G.; Moubaraki, B.; Hicks, T. J.

    2015-12-01

    The magnetic structure of the quasi-two-dimensional antiferromagnet NiPS3 has been determined by magnetometry and a variety of neutron diffraction techniques. The experiments show that the samples must be carefully handled, as gluing influences the magnetometry measurements while preferred orientation complicates the interpretation of powder diffraction measurements. Our global set of consistent measurements show numerous departures from previously published results. We show that the compound adopts a k = [010 ] antiferromagnetic structure with the moment directions mostly along the a axis, and that the paramagnetic susceptibility is isotropic. The critical behavior was also investigated through the temperature dependence of the magnetic Bragg peaks below the Néel temperature.

  14. A 30 ps Timing Resolution for Single Photons with Multi-pixel Burle MCP-PMT

    Energy Technology Data Exchange (ETDEWEB)

    Va' vra, J.; Benitez, J.; Coleman, J.; Leith, D.W.G.S.; Mazaheri, G.; Ratcliff, B.; Schwiening, J.; /SLAC

    2006-07-05

    We have achieved {approx}30 psec single-photoelectron and {approx}12ps for multi-photoelectron timing resolution with a new 64 pixel Burle MCP-PMT with 10 micron microchannel holes. We have also demonstrated that this detector works in a magnetic field of 15kG, and achieved a single-photoelectron timing resolution of better than 60 psec. The study is relevant for a new focusing DIRC RICH detector for particle identification at future Colliders such as the super B-factory or ILC, and for future TOF techniques. This study shows that a highly pixilated MCP-PMT can deliver excellent timing resolution.

  15. The OMERACT psoriatic arthritis magnetic resonance imaging scoring system (PsAMRIS): definitions of key pathologies, suggested MRI sequences, and preliminary scoring system for PsA Hands

    DEFF Research Database (Denmark)

    Østergaard, Mikkel; McQueen, Fiona; Wiell, Charlotte

    2009-01-01

    This article describes a preliminary OMERACT psoriatic arthritis magnetic resonance image scoring system (PsAMRIS) for evaluation of inflammatory and destructive changes in PsA hands, which was developed by the international OMERACT MRI in inflammatory arthritis group. MRI definitions of important...... pathologies in peripheral PsA and suggestions concerning appropriate MRI sequences for use in PsA hands are also provided....

  16. The Pantawid Pamilyang Pilipino Program (4Ps in Iloilo, Philippines: An Evaluation

    Directory of Open Access Journals (Sweden)

    Ronaldo F. Frufonga

    2015-12-01

    Full Text Available This study attempted to evaluate the Pantawid Pamilyang Pilipino Program (4Ps in Iloilo, Philippines. The Input-Process-Output Model was used. The participants were the 327 beneficiaries selected through random sampling method. Four municipalities in the Province of Iloilo with high poverty incidence, gap, and severity were included in the study. The data were gathered through survey-checklist form. The statistical tools used were frequency count, percentage, and mean done through the Statistical Package for the Social Sciences (SPSS software. Results revealed that there was ample evidence on the improvement in the preventive healthcare among pregnant women and younger children. Improvement was observed in the reduction of malnourished children. Results also showed an increase in the enrollment of children in public schools. Likewise, the attendance rate of children also increased. Accordingly, the decrease was observable in the incidence of child labor among children. The decrease to nearly 0% in the drop-out rate of school children was an indication of improvement. Moreover, the results showed that the beneficiaries spent the largest amount of income on food, followed by education, hospitalization (medicine, and savings. In the same manner, the 4Ps program increased parents’ participation in the Family Development Sessions to nearly 100%.

  17. Total coliforms, arsenic and cadmium exposure through drinking water in the Western Region of Ghana: application of multivariate statistical technique to groundwater quality.

    Science.gov (United States)

    Affum, Andrews Obeng; Osae, Shiloh Dede; Nyarko, Benjamin Jabez Botwe; Afful, Samuel; Fianko, Joseph Richmond; Akiti, Tetteh Thomas; Adomako, Dickson; Acquaah, Samuel Osafo; Dorleku, Micheal; Antoh, Emmanuel; Barnes, Felix; Affum, Enoch Acheampong

    2015-02-01

    In recent times, surface water resource in the Western Region of Ghana has been found to be inadequate in supply and polluted by various anthropogenic activities. As a result of these problems, the demand for groundwater by the human populations in the peri-urban communities for domestic, municipal and irrigation purposes has increased without prior knowledge of its water quality. Water samples were collected from 14 public hand-dug wells during the rainy season in 2013 and investigated for total coliforms, Escherichia coli, mercury (Hg), arsenic (As), cadmium (Cd) and physicochemical parameters. Multivariate statistical analysis of the dataset and a linear stoichiometric plot of major ions were applied to group the water samples and to identify the main factors and sources of contamination. Hierarchal cluster analysis revealed four clusters from the hydrochemical variables (R-mode) and three clusters in the case of water samples (Q-mode) after z score standardization. Principal component analysis after a varimax rotation of the dataset indicated that the four factors extracted explained 93.3 % of the total variance, which highlighted salinity, toxic elements and hardness pollution as the dominant factors affecting groundwater quality. Cation exchange, mineral dissolution and silicate weathering influenced groundwater quality. The ranking order of major ions was Na(+) > Ca(2+) > K(+) > Mg(2+) and Cl(-) > SO4 (2-) > HCO3 (-). Based on piper plot and the hydrogeology of the study area, sodium chloride (86 %), sodium hydrogen carbonate and sodium carbonate (14 %) water types were identified. Although E. coli were absent in the water samples, 36 % of the wells contained total coliforms (Enterobacter species) which exceeded the WHO guidelines limit of zero colony-forming unit (CFU)/100 mL of drinking water. With the exception of Hg, the concentration of As and Cd in 79 and 43 % of the water samples exceeded the WHO guideline limits of 10 and 3

  18. Semiconductor statistics

    CERN Document Server

    Blakemore, J S

    1962-01-01

    Semiconductor Statistics presents statistics aimed at complementing existing books on the relationships between carrier densities and transport effects. The book is divided into two parts. Part I provides introductory material on the electron theory of solids, and then discusses carrier statistics for semiconductors in thermal equilibrium. Of course a solid cannot be in true thermodynamic equilibrium if any electrical current is passed; but when currents are reasonably small the distribution function is but little perturbed, and the carrier distribution for such a """"quasi-equilibrium"""" co

  19. Statistics Clinic

    Science.gov (United States)

    Feiveson, Alan H.; Foy, Millennia; Ploutz-Snyder, Robert; Fiedler, James

    2014-01-01

    Do you have elevated p-values? Is the data analysis process getting you down? Do you experience anxiety when you need to respond to criticism of statistical methods in your manuscript? You may be suffering from Insufficient Statistical Support Syndrome (ISSS). For symptomatic relief of ISSS, come for a free consultation with JSC biostatisticians at our help desk during the poster sessions at the HRP Investigators Workshop. Get answers to common questions about sample size, missing data, multiple testing, when to trust the results of your analyses and more. Side effects may include sudden loss of statistics anxiety, improved interpretation of your data, and increased confidence in your results.

  20. Optimization of protease production by an actinomycete Strain, PS ...

    African Journals Online (AJOL)

    Actinomycetes were isolated from the sediment samples of an estuarine shrimp pond located along the south east coast of India. During the investigation, a total of 28 strains of actinomycetes were isolated and examined for their protease activity. Among them, one strain PS-18A which was tentatively identified as ...

  1. Optimization of protease production by an actinomycete Strain, PS ...

    African Journals Online (AJOL)

    STORAGESEVER

    Isolation Agar Medium in duplicate Petri plates. To minimize ... on the Petri plates were counted from 5th day onwards, up to 28th .... After the dialysis, the volume was measured and analyzed for proteins and stored in deep freezer. Taxonomic investigation. The genus level identification was made for the strain PS-18A using ...

  2. Framing Retention for Institutional Improvement: A 4 Ps Framework

    Science.gov (United States)

    Kalsbeek, David H.

    2013-01-01

    A 4 Ps framework for student retention strategy is a construct for reframing the retention discussion in a way that enables institutional improvement by challenging some conventional wisdom and prevailing perspectives that have characterized retention strategy for years. It opens new possibilities for action and improvement by suggesting that…

  3. Multipole stack for the 4 rings of the PS Booster

    CERN Multimedia

    CERN PhotoLab

    1976-01-01

    The PS Booster (originally 800 MeV, now 1.4 GeV) saw first beam in 1972, routine operation began in 1973. The strive for ever higher intensities required the addition of multipoles. Manufacture of 8 stacks of multipoles was launched in 1974, for installation in 1976. For details, see 7511120X.

  4. The Swelling Behaviour of Polystyrene (PS)/ Polyvinylacetate (Pvac ...

    African Journals Online (AJOL)

    The effect of the variation of the type of solvent responsible for the differences in the swelling kinetics of Polystyrene (PS) and Polyvinyl acetate (PVAc) blends was studied. The results showed that the nature of solvent control or affects the degree of swelling. Also, 1-V characteristics at temperature range of 323-363K shows ...

  5. Boiling treatment of ABS and PS plastics for flotation separation.

    Science.gov (United States)

    Wang, Chong-qing; Wang, Hui; Wu, Bao-xin; Liu, Qun

    2014-07-01

    A new physical method, namely boiling treatment, was developed to aid flotation separation of acrylonitrile-butadiene-styrene (ABS) and polystyrene (PS) plastics. Boiling treatment was shown to be effective in producing a hydrophilic surface on ABS plastic. Fourier Transform Infrared analysis was conducted to investigate the mechanism of boiling treatment of ABS. Surface rearrangement of polymer may be responsible for surface change of boiling treated ABS, and the selective influence of boiling treatment on the floatability of boiling treated plastics may be attributed to the difference in the molecular mobility of polymer chains. The effects of flotation time, frother concentration and particle size on flotation behavior of simple plastic were investigated. Based on flotation behavior of simple plastic, flotation separation of boiling treatment ABS and PS with different particle sizes was achieved efficiently. The purity of ABS and PS was up to 99.78% and 95.80%, respectively; the recovery of ABS and PS was up to 95.81% and 99.82%, respectively. Boiling treatment promotes the industrial application of plastics flotation and facilitates plastic recycling. Copyright © 2014 Elsevier Ltd. All rights reserved.

  6. CMS Statistics

    Data.gov (United States)

    U.S. Department of Health & Human Services — The CMS Center for Strategic Planning produces an annual CMS Statistics reference booklet that provides a quick reference for summary information about health...

  7. WPRDC Statistics

    Data.gov (United States)

    Allegheny County / City of Pittsburgh / Western PA Regional Data Center — Data about the usage of the WPRDC site and its various datasets, obtained by combining Google Analytics statistics with information from the WPRDC's data portal.

  8. Accident Statistics

    Data.gov (United States)

    Department of Homeland Security — Accident statistics available on the Coast Guard’s website by state, year, and one variable to obtain tables and/or graphs. Data from reports has been loaded for...

  9. Image Statistics

    Energy Technology Data Exchange (ETDEWEB)

    Wendelberger, Laura Jean [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-08-08

    In large datasets, it is time consuming or even impossible to pick out interesting images. Our proposed solution is to find statistics to quantify the information in each image and use those to identify and pick out images of interest.

  10. Trichomoniasis Statistics

    Science.gov (United States)

    ... Search Form Controls Cancel Submit Search the CDC Trichomoniasis Note: Javascript is disabled or is not supported ... Twitter STD on Facebook Sexually Transmitted Diseases (STDs) Trichomoniasis Statistics Recommend on Facebook Tweet Share Compartir In ...

  11. Reversible Statistics

    DEFF Research Database (Denmark)

    Tryggestad, Kjell

    2004-01-01

    The study aims is to describe how the inclusion and exclusion of materials and calculative devices construct the boundaries and distinctions between statistical facts and artifacts in economics. My methodological approach is inspired by John Graunt's (1667) Political arithmetic and more recent work...... within constructivism and the field of Science and Technology Studies (STS). The result of this approach is here termed reversible statistics, reconstructing the findings of a statistical study within economics in three different ways. It is argued that all three accounts are quite normal, albeit...... in different ways. The presence and absence of diverse materials, both natural and political, is what distinguishes them from each other. Arguments are presented for a more symmetric relation between the scientific statistical text and the reader. I will argue that a more symmetric relation can be achieved...

  12. psRNATarget: a plant small RNA target analysis server.

    Science.gov (United States)

    Dai, Xinbin; Zhao, Patrick Xuechun

    2011-07-01

    Plant endogenous non-coding short small RNAs (20-24 nt), including microRNAs (miRNAs) and a subset of small interfering RNAs (ta-siRNAs), play important role in gene expression regulatory networks (GRNs). For example, many transcription factors and development-related genes have been reported as targets of these regulatory small RNAs. Although a number of miRNA target prediction algorithms and programs have been developed, most of them were designed for animal miRNAs which are significantly different from plant miRNAs in the target recognition process. These differences demand the development of separate plant miRNA (and ta-siRNA) target analysis tool(s). We present psRNATarget, a plant small RNA target analysis server, which features two important analysis functions: (i) reverse complementary matching between small RNA and target transcript using a proven scoring schema, and (ii) target-site accessibility evaluation by calculating unpaired energy (UPE) required to 'open' secondary structure around small RNA's target site on mRNA. The psRNATarget incorporates recent discoveries in plant miRNA target recognition, e.g. it distinguishes translational and post-transcriptional inhibition, and it reports the number of small RNA/target site pairs that may affect small RNA binding activity to target transcript. The psRNATarget server is designed for high-throughput analysis of next-generation data with an efficient distributed computing back-end pipeline that runs on a Linux cluster. The server front-end integrates three simplified user-friendly interfaces to accept user-submitted or preloaded small RNAs and transcript sequences; and outputs a comprehensive list of small RNA/target pairs along with the online tools for batch downloading, key word searching and results sorting. The psRNATarget server is freely available at http://plantgrn.noble.org/psRNATarget/.

  13. Bayesian statistics an introduction

    CERN Document Server

    Lee, Peter M

    2012-01-01

    Bayesian Statistics is the school of thought that combines prior beliefs with the likelihood of a hypothesis to arrive at posterior beliefs. The first edition of Peter Lee’s book appeared in 1989, but the subject has moved ever onwards, with increasing emphasis on Monte Carlo based techniques. This new fourth edition looks at recent techniques such as variational methods, Bayesian importance sampling, approximate Bayesian computation and Reversible Jump Markov Chain Monte Carlo (RJMCMC), providing a concise account of the way in which the Bayesian approach to statistics develops as wel

  14. Evolutionary Statistical Procedures

    CERN Document Server

    Baragona, Roberto; Poli, Irene

    2011-01-01

    This proposed text appears to be a good introduction to evolutionary computation for use in applied statistics research. The authors draw from a vast base of knowledge about the current literature in both the design of evolutionary algorithms and statistical techniques. Modern statistical research is on the threshold of solving increasingly complex problems in high dimensions, and the generalization of its methodology to parameters whose estimators do not follow mathematically simple distributions is underway. Many of these challenges involve optimizing functions for which analytic solutions a

  15. The role of a conserved membrane proximal cysteine in altering αPS2CβPS integrin diffusion

    Science.gov (United States)

    Syed, Aleem; Arora, Neha; Bunch, Thomas A.; Smith, Emily A.

    2016-12-01

    Cysteine residues (Cys) in the membrane proximal region are common post-translational modification (PTM) sites in transmembrane proteins. Herein, the effects of a highly conserved membrane proximal α-subunit Cys1368 on the diffusion properties of αPS2CβPS integrins are reported. Sequence alignment shows that this cysteine is palmitoylated in human α3 and α6 integrin subunits. Replacing Cys1368 in wild-type integrins with valine (Val1368) putatively blocks a PTM site and alters integrins’ ligand binding and diffusion characteristics. Both fluorescence recovery after photobleaching (FRAP) and single particle tracking (SPT) diffusion measurements show Val1368 integrins are more mobile compared to wild-type integrins. Approximately 33% and 8% more Val1368 integrins are mobile as measured by FRAP and SPT, respectively. The mobile Val1368 integrins also exhibit less time-dependent diffusion, as measured by FRAP. Tandem mass spectrometry data suggest that Cys1368 contains a redox or palmitoylation PTM in αPS2CβPS integrins. This membrane proximal Cys may play an important role in the diffusion of other alpha subunits that contain this conserved residue.

  16. Comparison of Available Bandwidth Estimation Techniques in Packet-Switched Mobile Networks

    DEFF Research Database (Denmark)

    López Villa, Dimas; Ubeda Castellanos, Carlos; Teyeb, Oumer Mohammed

    2006-01-01

    of information regarding the available bandwidth in the transport network, as it could end up being the bottleneck rather than the air interface. This paper provides a comparative study of three well known available bandwidth estimation techniques, i.e. TOPP, SLoPS and pathChirp, taking into account......The relative contribution of the transport network towards the per-user capacity in mobile telecommunication systems is becoming very important due to the ever increasing air-interface data rates. Thus, resource management procedures such as admission, load and handover control can make use...... the statistical conditions of the available bandwidth and assessing the variability of their estimations. Simulation-based studies on a mobile transport network show that pathChirp outperforms TOPP and SLoPS, both in terms of accuracy and efficiency....

  17. Generation of future potential scenarios in an Alpine Catchment by applying bias-correction techniques, delta-change approaches and stochastic Weather Generators at different spatial scale. Analysis of their influence on basic and drought statistics.

    Science.gov (United States)

    Collados-Lara, Antonio-Juan; Pulido-Velazquez, David; Pardo-Iguzquiza, Eulogio

    2017-04-01

    Assessing impacts of potential future climate change scenarios in precipitation and temperature is essential to design adaptive strategies in water resources systems. The objective of this work is to analyze the possibilities of different statistical downscaling methods to generate future potential scenarios in an Alpine Catchment from historical data and the available climate models simulations performed in the frame of the CORDEX EU project. The initial information employed to define these downscaling approaches are the historical climatic data (taken from the Spain02 project for the period 1971-2000 with a spatial resolution of 12.5 Km) and the future series provided by climatic models in the horizon period 2071-2100 . We have used information coming from nine climate model simulations (obtained from five different Regional climate models (RCM) nested to four different Global Climate Models (GCM)) from the European CORDEX project. In our application we have focused on the Representative Concentration Pathways (RCP) 8.5 emissions scenario, which is the most unfavorable scenario considered in the fifth Assessment Report (AR5) by the Intergovernmental Panel on Climate Change (IPCC). For each RCM we have generated future climate series for the period 2071-2100 by applying two different approaches, bias correction and delta change, and five different transformation techniques (first moment correction, first and second moment correction, regression functions, quantile mapping using distribution derived transformation and quantile mapping using empirical quantiles) for both of them. Ensembles of the obtained series were proposed to obtain more representative potential future climate scenarios to be employed to study potential impacts. In this work we propose a non-equifeaseble combination of the future series giving more weight to those coming from models (delta change approaches) or combination of models and techniques that provides better approximation to the basic

  18. Statistical mechanics

    CERN Document Server

    Jana, Madhusudan

    2015-01-01

    Statistical mechanics is self sufficient, written in a lucid manner, keeping in mind the exam system of the universities. Need of study this subject and its relation to Thermodynamics is discussed in detail. Starting from Liouville theorem gradually, the Statistical Mechanics is developed thoroughly. All three types of Statistical distribution functions are derived separately with their periphery of applications and limitations. Non-interacting ideal Bose gas and Fermi gas are discussed thoroughly. Properties of Liquid He-II and the corresponding models have been depicted. White dwarfs and condensed matter physics, transport phenomenon - thermal and electrical conductivity, Hall effect, Magneto resistance, viscosity, diffusion, etc. are discussed. Basic understanding of Ising model is given to explain the phase transition. The book ends with a detailed coverage to the method of ensembles (namely Microcanonical, canonical and grand canonical) and their applications. Various numerical and conceptual problems ar...

  19. Statistical physics

    CERN Document Server

    Guénault, Tony

    2007-01-01

    In this revised and enlarged second edition of an established text Tony Guénault provides a clear and refreshingly readable introduction to statistical physics, an essential component of any first degree in physics. The treatment itself is self-contained and concentrates on an understanding of the physical ideas, without requiring a high level of mathematical sophistication. A straightforward quantum approach to statistical averaging is adopted from the outset (easier, the author believes, than the classical approach). The initial part of the book is geared towards explaining the equilibrium properties of a simple isolated assembly of particles. Thus, several important topics, for example an ideal spin-½ solid, can be discussed at an early stage. The treatment of gases gives full coverage to Maxwell-Boltzmann, Fermi-Dirac and Bose-Einstein statistics. Towards the end of the book the student is introduced to a wider viewpoint and new chapters are included on chemical thermodynamics, interactions in, for exam...

  20. Statistical mechanics

    CERN Document Server

    Schwabl, Franz

    2006-01-01

    The completely revised new edition of the classical book on Statistical Mechanics covers the basic concepts of equilibrium and non-equilibrium statistical physics. In addition to a deductive approach to equilibrium statistics and thermodynamics based on a single hypothesis - the form of the microcanonical density matrix - this book treats the most important elements of non-equilibrium phenomena. Intermediate calculations are presented in complete detail. Problems at the end of each chapter help students to consolidate their understanding of the material. Beyond the fundamentals, this text demonstrates the breadth of the field and its great variety of applications. Modern areas such as renormalization group theory, percolation, stochastic equations of motion and their applications to critical dynamics, kinetic theories, as well as fundamental considerations of irreversibility, are discussed. The text will be useful for advanced students of physics and other natural sciences; a basic knowledge of quantum mechan...

  1. [Retinal Cell Therapy Using iPS Cells].

    Science.gov (United States)

    Takahashi, Masayo

    2016-03-01

    Progress in basic research, starting with the work on neural stem cells in the middle 1990's to embryonic stem (ES) cells and induced pluripotent stem (iPS) cells at present, will lead the cell therapy (regenerative medicine) of various organs, including the central nervous system to a big medical field in the future. The author's group transplanted iPS cell-derived retinal pigment epithelial (RPE) cell sheets to the eye of a patient with exudative age-related macular degeneration (AMD) in 2014 as a clinical research. Replacement of the RPE with the patient's own iPS cell-derived young healthy cell sheet will be one new radical treatment of AMD that is caused by cellular senescence of RPE cells. Since it was the first clinical study using iPS cell-derived cells, the primary endpoint was safety judged by the outcome one year after surgery. The safety of the cell sheet has been confirmed by repeated tumorigenisity tests using immunodeficient mice, as well as purity of the cells, karyotype and genetic analysis. It is, however, also necessary to prove the safety by clinical studies. Following this start, a good strategy considering cost and benefit is needed to make regenerative medicine a standard treatment in the future. Scientifically, the best choice is the autologous RPE cell sheet, but autologous cell are expensive and sheet transplantation involves a risky part of surgical procedure. We should consider human leukocyte antigen (HLA) matched allogeneic transplantation using the HLA 6 loci homozyous iPS cell stock that Prof. Yamanaka of Kyoto University is working on. As the required forms of donor cells will be different depending on types and stages of the target diseases, regenerative medicine will be accomplished in a totally different manner from the present small molecule drugs. Proof of concept (POC) of photoreceptor transplantation in mouse is close to being accomplished using iPS cell-derived photoreceptor cells. The shortest possible course for treatment

  2. A transmissão psíquica geracional

    Directory of Open Access Journals (Sweden)

    Vinícius Oliveira dos Santos

    Full Text Available O artigo seguinte refere-se a um estudo sobre como ocorre a transmissão psíquica entre as gerações e qual sua importância na constituição psíquica do sujeito. É também objetivo deste artigo explicar o que são as transmissões intergeracional e transgeracional. Para buscar respostas para essas questões, fez-se uma pesquisa bibliográfica sobre a transmissão psíquica, pelo viés psicanalítico, principalmente a partir da teoria lacaniana e com conceitos oriundos da linguística saussuriana. Será a partir de uma determinada ordem simbólica, constituída pela linguagem que precede o sujeito, nomeado por Lacan como o Outro, que a transmissão psíquica entre gerações ganhará o seu caráter unívoco, sempre se tendo em mente a importância fundamental do recalcamento e de seus efeitos, bem como do retorno do recalcado nas diferentes gerações. A transmissão psíquica é necessária e concomitante à constituição do sujeito, e ocorre através da linguagem, dos significantes que irão determinar uma ordem simbólica para o ser que nasce através dos diferentes discursos que perpassam as gerações nas figuras dos pais desse novo ser. Essa ordem simbólica continuará a se fazer presente nesse novo sujeito pelo restante de sua existência. Este artigo busca dar nova luz ao aspecto da transmissão psíquica transgeracional, diferenciando-se da recalque s abordagens psicanalíticas contemporâneas por ser uma leitura lacaniana. Serão usados dois exemplos: um de como a transmissão aparece na cultura, outro, na subjetividade do sujeito através da arte.

  3. AP statistics

    CERN Document Server

    Levine-Wissing, Robin

    2012-01-01

    All Access for the AP® Statistics Exam Book + Web + Mobile Everything you need to prepare for the Advanced Placement® exam, in a study system built around you! There are many different ways to prepare for an Advanced Placement® exam. What's best for you depends on how much time you have to study and how comfortable you are with the subject matter. To score your highest, you need a system that can be customized to fit you: your schedule, your learning style, and your current level of knowledge. This book, and the online tools that come with it, will help you personalize your AP® Statistics prep

  4. Statistical inference

    CERN Document Server

    Rohatgi, Vijay K

    2003-01-01

    Unified treatment of probability and statistics examines and analyzes the relationship between the two fields, exploring inferential issues. Numerous problems, examples, and diagrams--some with solutions--plus clear-cut, highlighted summaries of results. Advanced undergraduate to graduate level. Contents: 1. Introduction. 2. Probability Model. 3. Probability Distributions. 4. Introduction to Statistical Inference. 5. More on Mathematical Expectation. 6. Some Discrete Models. 7. Some Continuous Models. 8. Functions of Random Variables and Random Vectors. 9. Large-Sample Theory. 10. General Meth

  5. Receptor-associated protein (RAP plays a central role in modulating Abeta deposition in APP/PS1 transgenic mice.

    Directory of Open Access Journals (Sweden)

    Guilian Xu

    Full Text Available BACKGROUND: Receptor associated protein (RAP functions in the endoplasmic reticulum (ER to assist in the maturation of several membrane receptor proteins, including low density lipoprotein receptor-related protein (LRP and lipoprotein receptor 11 (SorLA/LR11. Previous studies in cell and mouse model systems have demonstrated that these proteins play roles in the metabolism of the amyloid precursor protein (APP, including processes involved in the generation, catabolism and deposition of beta-amyloid (Abeta peptides. METHODOLOGY/PRINCIPAL FINDINGS: Mice transgenic for mutant APPswe and mutant presenilin 1 (PS1dE9 were mated to mice with homozygous deletion of RAP. Unexpectedly, mice that were homozygous null for RAP and transgenic for APPswe/PS1dE9 showed high post-natal mortality, necessitating a shift in focus to examine the levels of amyloid deposition in APPswe/PS1dE9 that were hemizygous null for RAP. Immunoblot analysis confirmed 50% reductions in the levels of RAP with modest reductions in the levels of proteins dependent upon RAP for maturation [LRP trend towards a 20% reduction ; SorLA/LR11 statistically significant 15% reduction (p<0.05]. Changes in the levels of these proteins in the brains of [APPswe/PS1dE9](+/-/RAP(+/- mice correlated with 30-40% increases in amyloid deposition by 9 months of age. CONCLUSIONS/SIGNIFICANCE: Partial reductions in the ER chaperone RAP enhance amyloid deposition in the APPswe/PS1dE9 model of Alzheimer amyloidosis. Partial reductions in RAP also affect the maturation of LRP and SorLA/LR11, which are each involved in several different aspects of APP processing and Abeta catabolism. Together, these findings suggest a central role for RAP in Alzheimer amyloidogenesis.

  6. Statistical Mechancis

    CERN Document Server

    Gallavotti, Giovanni

    2011-01-01

    C. Cercignani: A sketch of the theory of the Boltzmann equation.- O.E. Lanford: Qualitative and statistical theory of dissipative systems.- E.H. Lieb: many particle Coulomb systems.- B. Tirozzi: Report on renormalization group.- A. Wehrl: Basic properties of entropy in quantum mechanics.

  7. Statistical Computing

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 4; Issue 10. Statistical Computing - Understanding Randomness and Random Numbers. Sudhakar Kunte. Series Article Volume 4 Issue 10 October 1999 pp 16-21. Fulltext. Click here to view fulltext PDF. Permanent link:

  8. Transfer line from the PSB to the PS (recombination)

    CERN Multimedia

    CERN PhotoLab

    1976-01-01

    After sequential ejection of 5 bunches from each of the 4 rings of the Booster (originally 800 MeV, now 1.4 GeV), the 4 batches are brought to the same vertical level, so as to form a string of 20 bunches, filling the circumference of the PS. This vertical "recombination" is performed in the transfer line, using vertical bending magnets, septa and kickers. Here we see the section where the beam from ring 4 (the top one) is brought down to the level of ring 3, and the beam from ring 1 up to the level of ring 2. Further downstream (to the right, outside this picture), level 2 is brought up to level 3, identical to that of the PS. After this original recombination scheme, other ways of combining the 4 beams, vertically and/or longitudinally, were developed and used in operation.

  9. O Trabalho Psíquico da Intersubjetividade

    Directory of Open Access Journals (Sweden)

    Maria Inês Assumpção Fernandes

    2003-01-01

    Full Text Available O presente trabalho procura refletir sobre o trabalho psíquico da intersubjetividade nos grupos. Trata-se de pensá-lo na relação com a ruptura de investimentos durante o processo de Transformação x Criação, em primeiro lugar. A partir desse ponto, discutiremos a relação entre Transformação, Trabalho e Dispositivo. Neste caso pensamos nas possibilidades de intervenção, refletindo sobre a intervenção inpidual e a intervenção grupal. A questão da Transmissão Psíquica entre gerações será focalizada, fundamentalmente, no que se refere aos tempos lógicos do recalque.

  10. Images of Christ's Saving Work in Ps.-Epiphanius' Homilies

    Directory of Open Access Journals (Sweden)

    H. F. Stander

    1997-12-01

    Full Text Available Images of Christ's Saving Work in Ps.-Epiphanius' Homilies. One cannot really speak of a systematic theology on the subject of atone-ment in the patristic writers. Frances Young once said that 'it is in fact impossible to categorize neatly the thought of the major patristic writers on the subject of atonement'. She adds that one cannot do justice to the range of motifs and images that are found in describing the saving and atoning work of Christ if we merely dismember 'systematic theologies' to illustrate common soteriological themes. One can only appreciate patristic views of atonement if one begins by recognizing the multifaceted unity of imagery that pervades the literature. This then is the goal of this article: to discuss the rich images which Ps: -Epiphanius uses to describe the atoning work of Christ.

  11. Magnetoelectric MnPS3 as a candidate for ferrotoroidicity

    Science.gov (United States)

    Ressouche, E.; Loire, M.; Simonet, V.; Ballou, R.; Stunault, A.; Wildes, A.

    2010-09-01

    We have revisited the magnetic structure of manganese phosphorus trisulfide MnPS3 using neutron diffraction and polarimetry. MnPS3 undergoes a transition toward a collinear antiferromagnetic order at 78 K. The resulting magnetic point-group breaks both the time reversal and the space inversion thus allowing a linear magnetoelectric coupling. Neutron polarimetry was subsequently used to prove that this coupling provides a way to manipulate the antiferromagnetic domains simply by cooling the sample under crossed magnetic and electrical fields, in agreement with the nondiagonal form of the magnetoelectric tensor. In addition, this tensor has, in principle, an antisymmetric part that results in a toroidic moment and provides with a pure ferrotoroidic compound.

  12. PS Dreyer: Bakens op die pad van die wetenskap

    Directory of Open Access Journals (Sweden)

    A. J. Antonites

    1986-01-01

    Full Text Available PS Dreyer: Beacons on the path of science Professor PS Dreyer is an academic who has shown insight and vision into several problems of the human sciences since 1951. He has identified problems, but also contributed solutions to them. In this respect his philosophy on causality and freedom is of utmost importance. The same applies to his investigations into the relationship history-Christianity as well as the unity of sciences and how the concepts scientific, unscientic and nonscientific are related to one another. His contribution to the understanding of Greek philosophy should be of significance for time to come. Two milestones could be distinguished: Dreyer's particular solution to the problem of the criterion on truth, viz meaningfulness and his notion of the knowledge of values in ethics by valuation in contradistinction to knowledge through feeling, reason and will.

  13. Images of Christ's Saving Work in Ps.-Epiphanius' Homilies

    Directory of Open Access Journals (Sweden)

    H. F. Stander

    1997-01-01

    Full Text Available Images of Christ's Saving Work in Ps.-Epiphanius' Homilies. One cannot really speak of a systematic theology on the subject of atone-ment in the patristic writers. Frances Young once said that 'it is in fact impossible to categorize neatly the thought of the major patristic writers on the subject of atonement'. She adds that one cannot do justice to the range of motifs and images that are found in describing the saving and atoning work of Christ if we merely dismember 'systematic theologies' to illustrate common soteriological themes. One can only appreciate patristic views of atonement if one begins by recognizing the multifaceted unity of imagery that pervades the literature. This then is the goal of this article: to discuss the rich images which Ps: -Epiphanius uses to describe the atoning work of Christ.

  14. Longitudinal coupled-bunch instability studies in the PS

    CERN Document Server

    Damerau, H

    2017-01-01

    The main longitudinal limitation for LHC-type beams inthe PS are coupled-bunch instabilities. A dedicated proto-typefeedbacksystemusingaFinemetcavityasalongitudinalkicker has been installed. Extensive tests with beam havebeen performed to explore the intensity reach with this feed-back. The maximum intensity with nominal longitudinalemittance at PS extraction has been measured, as well as theemittance required to keep the beam longitudinally stableat the design intensity for the High-Luminosity LHC (HL-LHC). A higher-harmonic cavity is a complementary op-tion to extend the intensity reach beyond the capabilities ofthe coupled-bunch feedback. Preliminary machine develop-ment (MD) studies operating one20MHzor one40MHzRF system as a higher harmonic at the flat-top indicate thebeneficial effect on longitudinal beam stability

  15. Functional characterization of calcineurin homologs PsCNA1/PsCNB1 in Puccinia striiformis f. sp. tritici using a host-induced RNAi system.

    Directory of Open Access Journals (Sweden)

    Hong Zhang

    Full Text Available Calcineurin plays a key role in morphogenesis, pathogenesis and drug resistance in most fungi. However, the function of calcineurin genes in Puccinia striiformis f. sp. tritici (Pst is unclear. We identified and characterized the calcineurin genes PsCNA1 and PsCNB1 in Pst. Phylogenetic analyses indicate that PsCNA1 and PsCNB1 form a calcium/calmodulin regulated protein phosphatase belonging to the calcineurin heterodimers composed of subunits A and B. Quantitative RT-PCR analyses revealed that both PsCNA1 and PsCNB1 expression reached their maximum in the stage of haustorium formation, which is one day after inoculation. Using barely stripe mosaic virus (BSMV as a transient expression vector in wheat, the expression of PsCNA1 and PsCNB1 in Pst was suppressed, leading to slower extension of fungal hyphae and reduced production of urediospores. The immune-suppressive drugs cyclosporin A and FK506 markedly reduced the germination rates of urediospores, and when germination did occur, more than two germtubes were produced. These results suggest that the calcineurin signaling pathway participates in stripe rust morphogenetic differentiation, especially the formation of haustoria during the early stage of infection and during the production of urediospores. Therefore PsCNA1 and PsCNB1 can be considered important pathogenicity genes involved in the wheat-Pst interaction.

  16. Consolidation of the 45-Year Old PS Main Magnet System

    CERN Document Server

    Zickler, Thomas; Kalbreier, Wilhelm; Mess, Karl Hubert; Newborough, Antony

    2006-01-01

    After a major coil insulation breakdown on two of the 47-year-old CERN PS main magnets in 2003, an extensive magnet consolidation program has been launched. This article reviews the analysis of the magnet state be-fore the repair and the applied major improvements. An overview is given of the production of the new compo-nents, the actual refurbishment and the commissioning of the main magnet system after 18 months shutdown.

  17. Specification of the Beam Position Measurement in the PS Machine

    CERN Document Server

    Bravin, Enrico; Chanel, M; Ludwig, M; Métral, Elias; Métral, G; Potier, J P; Raich, U; Scrivens, R; Steerenberg, R; CERN. Geneva. AB Department

    2003-01-01

    This specification, drawn up by the instrumentation specification board 2, describes the requirements concerning orbit and trajectory measurements in the PS machine. The orbit measurement and the trajectory measurement are both indispensable in order to be able to guarantee the correct beam quality for beams like LHC, the future Grand Sasso beam, the nTOF beam and surely the combined operation of the nTOF beam and the East Area beam.

  18. Science spin: iPS cell research in the news.

    Science.gov (United States)

    Caulfield, T; Rachul, C

    2011-05-01

    Big scientific developments have always been spun to meet particular social agendas. We have seen it in the context of global warming, nuclear power, and genetically modified organisms. But few stories illustrate the phenomenon of spin as well as the reaction, and concomitant media coverage, that surrounded the November 2007 announcement regarding the reprogramming of skin cells to produce cells with qualities comparable to those of human embryonic stem cells (hESCs) known as induced pluripotent stem (iPS) cells.

  19. Physics at the AD/PS/SPS (1/4)

    CERN Multimedia

    CERN. Geneva

    2012-01-01

    Lecture 1: The CERN injector complex and beams for non-LHC physics. The various machines and beam lines in the CERN injector complex are presented, from the linacs to the SPS. Special emphasis is given to the beam lines at the PS and SPS machines: AD, North and East Areas, nTOF and CNGS and HiRadMad as well as the ion beams. A short outlook is given to possible future upgrades and projects.

  20. Ps18.pdf | sep2002 | jess | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; jess; sep2002; Ps18.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. Associates – 2017. Posted on 17 July 2017. Click here to see the list · 28th Mid Year Meeting. Posted on 26 May ...

  1. New Electron Cloud Detectors for the PS Main Magnets

    CERN Document Server

    Yin Vallgren, Ch; Gilardoni, S; Taborelli, M; Neupert, H; Ferreira Somoza, J

    2014-01-01

    Electron cloud (EC) has already been observed during normal operation of the PS, therefore it is necessary to study its in fluence on any beam instability for the future LHC Injector Upgrade (LIU). Two new electron cloud detectors have been discussed, developed and installed during the Long Shutdown (LS1) in one of the PS main magnets. The first measurement method is based on current measurement by using a shielded button-type pick-up. Due to the geometry and space limitation in the PS magnet, the button-type pick-up made of a 96%Al2O3 block coated with a thin layer of solvent-based Ag painting, placed 30 degrees to the bottom part of the vacuum chamber was installed in the horizontal direction where the only opening of the magnet coil is. The other newly developed measurement method is based on detection of photons emitted by the electrons from the electron cloud impinging on the vacuum chamber walls. The emitted photons are reected to a quartz window. A MCP-PMT (Micro-Channel Plate Photomultiplier Tube) wit...

  2. LS1 Report: PS Booster prepares for beam

    CERN Multimedia

    Katarina Anthony

    2014-01-01

    With Linac2 already up and running, the countdown to beam in the LHC has begun! The next in line is the PS Booster, which will close up shop to engineers early next week. The injector will be handed over to the Operations Group who are tasked with getting it ready for active duty.   Taken as we approach the end of LS1 activities, this image shows where protons will soon be injected from Linac2 into the four PS Booster rings. Over the coming two months, the Operations Group will be putting the Booster's new elements through their paces. "Because of the wide range of upgrades and repairs carried out in the Booster, we have a very full schedule of tests planned for the machine," says Bettina Mikulec, PS Booster Engineer in Charge. "We will begin with cold checks; these are a wide range of tests carried out without beam, including system tests with power on/off and with varying settings, as well as verification of the controls system and timings." Amon...

  3. [Descriptive statistics].

    Science.gov (United States)

    Rendón-Macías, Mario Enrique; Villasís-Keever, Miguel Ángel; Miranda-Novales, María Guadalupe

    2016-01-01

    Descriptive statistics is the branch of statistics that gives recommendations on how to summarize clearly and simply research data in tables, figures, charts, or graphs. Before performing a descriptive analysis it is paramount to summarize its goal or goals, and to identify the measurement scales of the different variables recorded in the study. Tables or charts aim to provide timely information on the results of an investigation. The graphs show trends and can be histograms, pie charts, "box and whiskers" plots, line graphs, or scatter plots. Images serve as examples to reinforce concepts or facts. The choice of a chart, graph, or image must be based on the study objectives. Usually it is not recommended to use more than seven in an article, also depending on its length.

  4. Statistical mechanics of superconductivity

    CERN Document Server

    Kita, Takafumi

    2015-01-01

    This book provides a theoretical, step-by-step comprehensive explanation of superconductivity for undergraduate and graduate students who have completed elementary courses on thermodynamics and quantum mechanics. To this end, it adopts the unique approach of starting with the statistical mechanics of quantum ideal gases and successively adding and clarifying elements and techniques indispensible for understanding it. They include the spin-statistics theorem, second quantization, density matrices, the Bloch–De Dominicis theorem, the variational principle in statistical mechanics, attractive interaction, and bound states. Ample examples of their usage are also provided in terms of topics from advanced statistical mechanics such as two-particle correlations of quantum ideal gases, derivation of the Hartree–Fock equations, and Landau’s Fermi-liquid theory, among others. With these preliminaries, the fundamental mean-field equations of superconductivity are derived with maximum mathematical clarity based on ...

  5. Kultuur isiksuse psühholoogiat ei mõjuta / Tiit Kändler

    Index Scriptorium Estoniae

    Kändler, Tiit, 1948-

    2010-01-01

    Psühholoogia uuemate andmete kohaselt ei sõltu indiviidi seadumus kultuurist, soost, vanusest, haridusest. Eesti psühholoogide Jüri Alliku ja Ann Realo osalusel ajakirjas "Journal Personality and Social Psychology" ilmunud artiklist

  6. Kultuur isiksuse psühholoogiat ei mõjuta / Tiit Kändler

    Index Scriptorium Estoniae

    Kändler, Tiit, 1948-

    2005-01-01

    Psühholoogia uuemate andmete kohaselt ei sõltu indiviidi seadumus kultuurist, soost, vanusest, haridusest. Eesti psühholoogide Jüri Alliku ja Anu Realo osalusel ajakirjas "Journal Personality and Social Psychology" ilmunud artiklist

  7. Comparative, validity and responsiveness of the HOOS-PS and KOOS-PS to the WOMAC physical function subscale in total joint replacement for osteoarthritis

    DEFF Research Database (Denmark)

    Davis, A M; Perruccio, A V; Canizares, M

    2009-01-01

    OBJECTIVE: To evaluate the internal consistency of the Hip disability and Osteoarthritis Outcome Score-Physical Function Short-form (HOOS-PS) and the Knee injury and Osteoarthritis Outcome Score-Physical Function Short-form (KOOS-PS) in total hip replacement (THR) and total knee (TKR) replacement....... Construct validity and responsiveness were compared to the Western Ontario McMaster Universities' Osteoarthritis Index (WOMAC) Likert 3.0 physical function (PF) subscale and the PF excluding the items in the short measures (PF-exclusions). METHODS: Participants completed the full HOOS or KOOS, measures...... of fatigue, anxiety, depression and the Chronic Pain Grade (CPG) pre-surgery and the HOOS or KOOS 6 months post-surgery. Internal consistency for the HOOS-PS and KOOS-PS was calculated using Cronbach's alpha. For construct validity, it was hypothesized that correlations between the HOOS-PS or KOOS-PS and PF...

  8. Analüütilised voolud psühholoogias ja nende rakendamine pedagoogikas / Aleksander Elango

    Index Scriptorium Estoniae

    Elango, Aleksander, 1902-2004

    2001-01-01

    Analüütise psühholoogia kolm koolkonda - S.Freudì koolkond e. päris-psühhoanalüüs, A.Adlerì koolkond e. individuaalpsühholoogia ja C.G.Jungì psühhoanalüüsi ja individuaalpsühholoogia sünteesi luua püüdev koolkond. Analüütise psühholoogia koolkondade ja pedagoogika suhetest

  9. PP and PS seismic response from fractured tight gas reservoirs: a case study

    Science.gov (United States)

    Jianming, Tang; Shaonan, Zhang; Li, Xiang-Yang

    2008-03-01

    In this paper, we present an example of using PP and PS converted-wave data recorded by digital micro-eletro-mechanical-systems (MEMS) to evaluate a fractured tight gas reservoir from the Xinchang gas field in Sichuan, China. For this, we analyse the variations in converted shear-wave splitting, Vp/Vs ratio and PP and PS impedance, as well as other attributes based on absorption and velocity dispersion. The reservoir formation is tight sandstone, buried at a depth of about 5000 m, and the converted-wave data reveal significant shear-wave splitting over the reservoir formation. We utilize a rotation technique to extract the shear-wave polarization and time delay from the data, and a small-window correlation method to build time-delay spectra that allow the generation of a time-delay section. At the reservoir formation, the shear-wave time delay is measured at 20 ms, about 15% shear-wave anisotropy, correlating with the known gas reservoirs. Furthermore, the splitting anomalies are consistent with the characteristics of other attributes such as Vp/Vs ratio and P- and S-wave acoustic and elastic impedance. The P-wave shows consistent low impedance over the reservoir formation, whilst the S-wave impedance shows relatively high impedance. The calculated gas indicator based on absorption and velocity dispersion yields a high correlation with the gas bearing formations. This confirms the benefit of multicomponent seismic data from digital MEMS sensors.

  10. Collagen birefringence assessment in heart chordae tendineae through PS-OCT

    Science.gov (United States)

    Real, Eusebio; Revuelta, José M.; González-Vargas, Nieves; Pontón, Alejandro; Calvo-Díez, Marta; López-Higuera, José M.; Conde, Olga M.

    2017-02-01

    Degenerative mitral regurgitation is a serious and frequent human heart valve disease. Malfunctioning of this valve brings the left-sided heart through a significant increase of pressure and volume overload. Severe degenerative mitral incompetence generally requires surgical repair or valve replacement with a bioprosthesis or mechanical heart valve. Degenerative disease affects the leaflets or/and the chordae tendineae, which link both leaflets to the papillary muscles. During mitral valve surgical repair, reconstruction of the valve leaflets, annulus and chordae are provided to prevent postoperative recurrence of valve regurgitation. The operative evaluation of the diseased and apparently normal chordae tendineae mainly depends of the surgeońs experience, without any other objective diagnosis tool. In this work, PS-OCT (Polarization Sensitive-Optical Coherence Tomography) is applied for the first time to evaluate the pathological condition of human chordae coming from the mitral valve. It consists on a prospective study to test the viability of this technique for the evaluation of the collagen core of chords. This core presents a strong birefringence due to the longitudinal and organized arrangement of its collagen bundles. Different densities and organizations of the collagen core translate into different birefringence indicators whose measurement become an objective marker of the core structure. Ex-vivo mitral degenerative chordae tendineae have been analyzed with PS-OCT. Intensity OCT is used to obtain complementary morphological information of the chords. Birefringence results correlate with the previously reported values for human tendinous tissue.

  11. File list: His.PSC.05.AllAg.iPS_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available His.PSC.05.AllAg.iPS_cells hg19 Histone Pluripotent stem cell iPS cells SRX317576,S...077,SRX317607 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/His.PSC.05.AllAg.iPS_cells.bed ...

  12. File list: His.PSC.50.AllAg.iPS_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available His.PSC.50.AllAg.iPS_cells mm9 Histone Pluripotent stem cell iPS cells SRX977417,SR...RX127376,SRX146530,SRX146522,SRX146547,SRX333561,SRX035985,SRX1090869 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/His.PSC.50.AllAg.iPS_cells.bed ...

  13. File list: ALL.PSC.50.AllAg.iPS_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.PSC.50.AllAg.iPS_cells hg19 All antigens Pluripotent stem cell iPS cells SRX088...16,SRX189400,SRX189399 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/ALL.PSC.50.AllAg.iPS_cells.bed ...

  14. File list: His.PSC.10.AllAg.iPS_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available His.PSC.10.AllAg.iPS_cells hg19 Histone Pluripotent stem cell iPS cells SRX110016,S...315,SRX381309 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/His.PSC.10.AllAg.iPS_cells.bed ...

  15. File list: ALL.PSC.20.AllAg.iPS_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.PSC.20.AllAg.iPS_cells hg19 All antigens Pluripotent stem cell iPS cells SRX088...27,SRX189400,SRX189399 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/ALL.PSC.20.AllAg.iPS_cells.bed ...

  16. File list: His.PSC.50.AllAg.iPS_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available His.PSC.50.AllAg.iPS_cells hg19 Histone Pluripotent stem cell iPS cells SRX110015,S...079,SRX317585 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/His.PSC.50.AllAg.iPS_cells.bed ...

  17. File list: Pol.PSC.20.AllAg.iPS_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.PSC.20.AllAg.iPS_cells mm9 RNA polymerase Pluripotent stem cell iPS cells SRX97...7435,SRX977434,SRX027462 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Pol.PSC.20.AllAg.iPS_cells.bed ...

  18. File list: ALL.PSC.05.AllAg.iPS_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.PSC.05.AllAg.iPS_cells hg19 All antigens Pluripotent stem cell iPS cells SRX753...00,SRX189399,SRX317607 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/ALL.PSC.05.AllAg.iPS_cells.bed ...

  19. File list: Pol.PSC.10.AllAg.iPS_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.PSC.10.AllAg.iPS_cells mm9 RNA polymerase Pluripotent stem cell iPS cells SRX97...7435,SRX977434,SRX027462 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Pol.PSC.10.AllAg.iPS_cells.bed ...

  20. File list: ALL.PSC.05.AllAg.iPS_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.PSC.05.AllAg.iPS_cells mm9 All antigens Pluripotent stem cell iPS cells SRX9774...30,SRX146524,SRX146522,SRX146547 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/ALL.PSC.05.AllAg.iPS_cells.bed ...

  1. File list: Oth.PSC.50.AllAg.iPS_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.50.AllAg.iPS_cells mm9 TFs and others Pluripotent stem cell iPS cells SRX97...RX146524 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.50.AllAg.iPS_cells.bed ...

  2. File list: Pol.PSC.50.AllAg.iPS_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.PSC.50.AllAg.iPS_cells mm9 RNA polymerase Pluripotent stem cell iPS cells SRX97...7435,SRX977434,SRX027462 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Pol.PSC.50.AllAg.iPS_cells.bed ...

  3. File list: DNS.PSC.20.AllAg.iPS_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available DNS.PSC.20.AllAg.iPS_cells hg19 DNase-seq Pluripotent stem cell iPS cells SRX040379...,SRX040378,SRX135563,SRX040377,SRX040376,SRX189427,SRX189400,SRX189399 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/DNS.PSC.20.AllAg.iPS_cells.bed ...

  4. File list: DNS.PSC.10.AllAg.iPS_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available DNS.PSC.10.AllAg.iPS_cells hg19 DNase-seq Pluripotent stem cell iPS cells SRX040379...,SRX040378,SRX040377,SRX040376,SRX135563,SRX189427,SRX189400,SRX189399 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/DNS.PSC.10.AllAg.iPS_cells.bed ...

  5. File list: Pol.PSC.05.AllAg.iPS_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.PSC.05.AllAg.iPS_cells mm9 RNA polymerase Pluripotent stem cell iPS cells SRX97...7435,SRX027462,SRX977434 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Pol.PSC.05.AllAg.iPS_cells.bed ...

  6. File list: ALL.PSC.10.AllAg.iPS_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.PSC.10.AllAg.iPS_cells hg19 All antigens Pluripotent stem cell iPS cells SRX753...09,SRX189400,SRX189399 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/ALL.PSC.10.AllAg.iPS_cells.bed ...

  7. File list: His.PSC.10.AllAg.iPS_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available His.PSC.10.AllAg.iPS_cells mm9 Histone Pluripotent stem cell iPS cells SRX977417,SR...RX127372,SRX1090869,SRX127376,SRX035977,SRX146530,SRX146547,SRX146522 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/His.PSC.10.AllAg.iPS_cells.bed ...

  8. File list: Oth.PSC.20.AllAg.iPS_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.20.AllAg.iPS_cells mm9 TFs and others Pluripotent stem cell iPS cells SRX97...RX146524 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.20.AllAg.iPS_cells.bed ...

  9. File list: DNS.PSC.05.AllAg.iPS_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available DNS.PSC.05.AllAg.iPS_cells hg19 DNase-seq Pluripotent stem cell iPS cells SRX040379...,SRX040378,SRX040377,SRX040376,SRX135563,SRX189427,SRX189400,SRX189399 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/DNS.PSC.05.AllAg.iPS_cells.bed ...

  10. File list: His.PSC.20.AllAg.iPS_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available His.PSC.20.AllAg.iPS_cells mm9 Histone Pluripotent stem cell iPS cells SRX127389,SR...RX127372,SRX127373,SRX1090869,SRX127376,SRX146530,SRX146522,SRX146547 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/His.PSC.20.AllAg.iPS_cells.bed ...

  11. Genomic imprinting is variably lost during reprogramming of mouse iPS cells.

    Science.gov (United States)

    Takikawa, Sachiko; Ray, Chelsea; Wang, Xin; Shamis, Yulia; Wu, Tien-Yuan; Li, Xiajun

    2013-09-01

    Derivation of induced pluripotent stem (iPS) cells is mainly an epigenetic reprogramming process. It is still quite controversial how genomic imprinting is reprogrammed in iPS cells. Thus, we derived multiple iPS clones from genetically identical mouse somatic cells. We found that parentally inherited imprint was variably lost among these iPS clones. Concurrent with the loss of DNA methylation imprint at the corresponding Snrpn and Peg3 imprinted regions, parental origin-specific expression of the Snrpn and Zim1 imprinted genes was also lost in these iPS clones. This loss of parental genomic imprinting in iPS cells was likely caused by the reprogramming process during iPS cell derivation because extended culture of iPS cells did not lead to significant increase in the loss of genomic imprinting. Intriguingly, one to several paternal chromosomes appeared to have acquired de novo methylation at the Snrpn and Zac1 imprinted regions in a high percentage of iPS clones. These results might have some implications for future therapeutic applications of iPS cells. Since DNA methylation imprint can be completely erased in some iPS clones at multiple imprinted regions, iPS cell reprogramming may also be employed to dissect the underlying mechanisms of erasure, reacquisition and maintenance of genomic imprinting in mammals. Copyright © 2013. Published by Elsevier B.V.

  12. File list: Oth.PSC.10.AllAg.iPS_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.10.AllAg.iPS_cells mm9 TFs and others Pluripotent stem cell iPS cells SRX65...RX146524 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.10.AllAg.iPS_cells.bed ...

  13. File list: His.PSC.05.AllAg.iPS_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available His.PSC.05.AllAg.iPS_cells mm9 Histone Pluripotent stem cell iPS cells SRX977417,SR...RX127374,SRX127373,SRX1090869,SRX333561,SRX146530,SRX146522,SRX146547 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/His.PSC.05.AllAg.iPS_cells.bed ...

  14. File list: ALL.PSC.10.AllAg.iPS_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.PSC.10.AllAg.iPS_cells mm9 All antigens Pluripotent stem cell iPS cells SRX9774...30,SRX146524,SRX146547,SRX146522 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/ALL.PSC.10.AllAg.iPS_cells.bed ...

  15. File list: ALL.PSC.50.AllAg.iPS_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.PSC.50.AllAg.iPS_cells mm9 All antigens Pluripotent stem cell iPS cells SRX9773...1,SRX035985,SRX1090869 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/ALL.PSC.50.AllAg.iPS_cells.bed ...

  16. File list: ALL.PSC.20.AllAg.iPS_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.PSC.20.AllAg.iPS_cells mm9 All antigens Pluripotent stem cell iPS cells SRX9773...30,SRX146522,SRX146547 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/ALL.PSC.20.AllAg.iPS_cells.bed ...

  17. File list: His.PSC.20.AllAg.iPS_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available His.PSC.20.AllAg.iPS_cells hg19 Histone Pluripotent stem cell iPS cells SRX110015,S...315,SRX381309 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/His.PSC.20.AllAg.iPS_cells.bed ...

  18. File list: Oth.PSC.05.AllAg.iPS_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.05.AllAg.iPS_cells mm9 TFs and others Pluripotent stem cell iPS cells SRX65...RX146524 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.05.AllAg.iPS_cells.bed ...

  19. File list: DNS.PSC.50.AllAg.iPS_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available DNS.PSC.50.AllAg.iPS_cells hg19 DNase-seq Pluripotent stem cell iPS cells SRX040379...,SRX040378,SRX135563,SRX040376,SRX040377,SRX189427,SRX189400,SRX189399 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/DNS.PSC.50.AllAg.iPS_cells.bed ...

  20. Statistical mechanics

    CERN Document Server

    Sheffield, Scott

    2009-01-01

    In recent years, statistical mechanics has been increasingly recognized as a central domain of mathematics. Major developments include the Schramm-Loewner evolution, which describes two-dimensional phase transitions, random matrix theory, renormalization group theory and the fluctuations of random surfaces described by dimers. The lectures contained in this volume present an introduction to recent mathematical progress in these fields. They are designed for graduate students in mathematics with a strong background in analysis and probability. This book will be of particular interest to graduate students and researchers interested in modern aspects of probability, conformal field theory, percolation, random matrices and stochastic differential equations.

  1. Ser-261 phospho-regulation is involved in pS256 and pS269-mediated aquaporin-2 apical translocation.

    Science.gov (United States)

    Yui, Naofumi; Ando, Fumiaki; Sasaki, Sei; Uchida, Shinichi

    2017-08-26

    Vasopressin catalyzes aquaporin-2 phosphorylation at several serine sites in the C-terminal region. Compared with Ser-256 and Ser-269 phosphorylation, the role of Ser-261 phospho-regulation on vasopressin-regulated AQP2 apical translocation is largely unknown. In addition, recent discovery of transcytotic apical delivery of AQP2 made the concept of its intracellular trafficking even more complicated. In this study, we evaluated how intact phospho-AQP2 signals fit with the transcytosis trafficking model in Madin-Darby canine kidney cells. PS256 and pS269 signals were intracellularly detectable in wild-type AQP2 at the beginning of forskolin stimulation (1 min). These phospho-signals were detectable in basolateral membranes even after 10 min of stimulation. AQP2 stably inserted in the apical membrane increased pS269 and decreased pS261 signals. In an NDI-causing mutant P262L-AQP2, in which Ser-261 phospho-regulation is impaired, the pS256 and pS269 signals were detectable in the basolateral membranes with increased pS261 signals after forskolin stimulation. These results suggest that Ser-261 phospho-regulation is involved in pS256- and pS269-mediated AQP2 apical translocation. Copyright © 2017 Elsevier Inc. All rights reserved.

  2. Create and Publish a Hierarchical Progressive Survey (HiPS)

    Science.gov (United States)

    Fernique, P.; Boch, T.; Pineau, F.; Oberto, A.

    2014-05-01

    Since 2009, the CDS promotes a method for visualizing based on the HEALPix sky tessellation. This method, called “Hierarchical Progressive Survey" or HiPS, allows one to display a survey progressively. It is particularly suited for all-sky surveys or deep fields. This visualization method is now integrated in several applications, notably Aladin, the SiTools/MIZAR CNES framework, and the recent HTML5 “Aladin Lite". Also, more than one hundred surveys are already available in this view mode. In this article, we will present the progress concerning this method and its recent adaptation to the astronomical catalogs such as the GAIA simulation.

  3. Electrostatic septum for "Continuous Transfer" from PS to SPS

    CERN Multimedia

    CERN PhotoLab

    1982-01-01

    For "Continuous Transfer" to the SPS, the PS beam, after acceleration, is peeled off in 5 turns. To minimize losses, the magnetic septa are preceded by an electrostatic septum in straight section 31. We see the inner part of it, on a lab-bench. The first part consists of W-wires, the second part is a Mo-foil. The circulating beam passes through the opening, the ejected beam at the outside (above the wires, in this picture). This assembly is the anode-part, the cathode is not shown.

  4. Lo irreductible social y lo irreductible psíquico

    Directory of Open Access Journals (Sweden)

    Vincent Gaulejac, de

    2017-06-01

    Full Text Available Con base en la reconstrucción de las polaridades explicativas -lo irreductible social y lo irreductible psíquico-que atraviesan a las ciencias sociales, este texto propone trascender los modelos antagónicos y excluyentes. El objetivo es instaurar en el centro de la reflexión la idea de la dialktica existencial que restituye al sujeto tanto el contexto socio-histórico en el cual está localizado como el deseo y la singularidad que lo constituyen en productor de la afirmación de su individualidad y su historicidad.

  5. PS potential performance with a higher injection energy

    CERN Document Server

    Gilardoni, S; Borburgh, J; Bodart, D; Chiggiato, P; Damerau, H; Hancock, S; Metral, G; Pittet, S; Rossi, C; Rumolo, G; Steerenberg, R; Widorski, M

    2011-01-01

    In the context of the LHC Injectors upgrade project, the PS has to be brought up to − and to operate reliably at − the level of performance required by the HL-LHC until the end of the LHC lifetime. The study has started on the potential benefits of increasing the injection energy. An overview of the impact of this upgrade will be presented, with a preliminary estimate of the beam characteristics at the SPS entrance and the remaining performance limitations. The necessary hardware modifications will be described, highlighting the critical systems and the risks. The program for the 2011 machine studies and hardware interventions for refining these plans will be presented.

  6. Injection and transfer lines of the PS Booster

    CERN Multimedia

    Photographic Service

    1972-01-01

    In the foreground is the vacuum chamber for the 50 MeV proton beam coming from the Linac. The tank held by white frames houses the "Vertical Distributor", which deflects the Linac beam to the levels of the Booster's 4 superposed rings. After acceleration in the Booster, originally to 800 MeV, today to 1.4 GeV, the beams from the 4 rings are combined in the vertical plane and transfered to the 26 GeV PS. The "Recombination Line", intersecting the injection line, crosses the picture from left to right.

  7. Search for Decays of Heavy Neutrinos with the PS Beam

    CERN Multimedia

    2002-01-01

    The experiment searches for neutrino decay, primarily into the e|+e|-@n^e and @g@g@n^e modes. Neutrino masses in the region between 1 and 400~MeV will be explored. The beam used is the neutrino PS beam used for the oscillation experiments. The apparatus consists of a decay volume @=30~m long and a calorimeter @=8~radiation lengths thick and @=20~m|2 in surface. The detectors are flash-tube modules of the type developed at Saclay for the proton-stability experiment. Scintillator hodoscopes give the timing information necessary for the trigger logic and background rejection.

  8. Reliability and maintenance analysis of the CERN PS booster

    CERN Document Server

    Staff, P S B

    1977-01-01

    The PS Booster Synchrotron being a complex accelerator with four superposed rings and substantial additional equipment for beam splitting and recombination, doubts were expressed at the time of project authorization as to its likely operational reliability. For 1975 and 1976, the average down time was 3.2% (at least one ring off) or 1.5% (all four rings off). The items analysed are: operational record, design features, maintenance, spare parts policy, operating temperature, effects of thunderstorms, fault diagnostics, role of operations staff and action by experts. (15 refs).

  9. Viscometric characterization of PS/POSS hybrid nanocomposites

    OpenAIRE

    Bianchi, Otávio; Repenning, Gustavo B.; Mauler, Raquel S.; Oliveira, Ricardo V. B.; Canto, Leonardo B.

    2012-01-01

    Nanocompósitos híbridos de poliestireno (PS) e poliedros oligoméricos silsesquioxanos (POSS) com diferentes composições e graus de hibridização foram obtidos por processamento reativo no estado fundido utilizando-se peróxido de dicumila (DCP) como iniciador, na presença ou não de estireno como agente de transferência de radical. Os materiais foram caracterizados viscosimetricamente por cromatografia de permeação em gel (GPC) usando detecção tripla por espalhamento de luz, viscosimetria e índi...

  10. A multiturn measurement system for the CERN PS

    CERN Document Server

    Angoletta, Maria Elena

    2002-01-01

    Multiturn beam position measurements on one or more pickups provide very important information needed to derive machine optics parameters. A variety of analyses is possible, such as determination of phase advance, detuning with amplitude, and most important, the exploration of phase space. In this paper we present a new multiturn acquisition system for the CERN proton synchrotron (CERN PS) based on a compact PCI fast digitiser and a new general object-oriented visualisation and analysis tool for the acquired multiturn data. (11 refs).

  11. Statistical Neurodynamics.

    Science.gov (United States)

    Paine, Gregory Harold

    1982-03-01

    The primary objective of the thesis is to explore the dynamical properties of small nerve networks by means of the methods of statistical mechanics. To this end, a general formalism is developed and applied to elementary groupings of model neurons which are driven by either constant (steady state) or nonconstant (nonsteady state) forces. Neuronal models described by a system of coupled, nonlinear, first-order, ordinary differential equations are considered. A linearized form of the neuronal equations is studied in detail. A Lagrange function corresponding to the linear neural network is constructed which, through a Legendre transformation, provides a constant of motion. By invoking the Maximum-Entropy Principle with the single integral of motion as a constraint, a probability distribution function for the network in a steady state can be obtained. The formalism is implemented for some simple networks driven by a constant force; accordingly, the analysis focuses on a study of fluctuations about the steady state. In particular, a network composed of N noninteracting neurons, termed Free Thinkers, is considered in detail, with a view to interpretation and numerical estimation of the Lagrange multiplier corresponding to the constant of motion. As an archetypical example of a net of interacting neurons, the classical neural oscillator, consisting of two mutually inhibitory neurons, is investigated. It is further shown that in the case of a network driven by a nonconstant force, the Maximum-Entropy Principle can be applied to determine a probability distribution functional describing the network in a nonsteady state. The above examples are reconsidered with nonconstant driving forces which produce small deviations from the steady state. Numerical studies are performed on simplified models of two physical systems: the starfish central nervous system and the mammalian olfactory bulb. Discussions are given as to how statistical neurodynamics can be used to gain a better

  12. Statistical mechanics of learning

    CERN Document Server

    Engel, Andreas

    2001-01-01

    The effort to build machines that are able to learn and undertake tasks such as datamining, image processing and pattern recognition has led to the development of artificial neural networks in which learning from examples may be described and understood. The contribution to this subject made over the past decade by researchers applying the techniques of statistical mechanics is the subject of this book. The authors provide a coherent account of various important concepts and techniques that are currently only found scattered in papers, supplement this with background material in mathematics and physics, and include many examples and exercises.

  13. [PS II photochemical efficiency in flag leaf of wheat varieties and its adaptation to strong sun- light intensity on farmland of Xiangride in Qinghai Province, Northwest China].

    Science.gov (United States)

    Shi, Sheng-Bo; Chen, Wen-Jie; Shi, Rui; Li, Miao; Zhang, Huai-Gang; Sun, Ya-Nan

    2014-09-01

    Taking four wheat varieties developed by Northwest Institute of Plateau Biology, Chinese Academy of Sciences, as test materials, with the measurement of content of photosynthetic pigments, leaf area, fresh and dry mass of flag leaf, the PS II photochemistry efficiency of abaxial and adaxial surface of flag leaf and its adaptation to strong solar radiation during the period of heading stage in Xiangride region were investigated with the pulse-modulated in-vivo chlorophyll fluorescence technique. The results indicated that flag leaf angle mainly grew in horizontal state in Gaoyuan 314, Gaoyuan 363 and Gaoyuan 584, and mainly in vertical state in Gaoyuan 913 because of its smaller leaf area and larger width. Photosynthetic pigments were different among the 4 varieties, and positively correlated with intrinsic PS II photochemistry efficiencies (Fv/Fm). In clear days, especially at noon, the photosynthetic photoinhibition was more serious in abaxial surface of flag leaf due to directly facing the solar radiation, but it could recover after reduction of sunlight intensity in the afternoon, which meant that no inactive damage happened in PS II reaction centers. There were significant differences of PS II actual and maximum photochemical efficiencies at the actinic light intensity (ΦPS II and Fv'/Fm') between abaxial and adaxial surface, and their relative variation trends were on the contrary. The photochemical and non-photochemical quenching coefficients (qP and NPQ) had a similar tendency in both abaxial and adaxial surfaces. Although ΦPS II and qP were lower in adaxial surface of flag leaf, the Fv'/Fm' was significantly higher, which indicated that the potential PS II capture efficiency of excited energy was higher. The results demonstrated that process of photochemical and non-photochemical quenching could effectively dissipate excited energy caused by strong solar radiation, and there were higher adaptation capacities in wheat varieties natively cultivated in

  14. Statistics of the galaxy distribution

    CERN Document Server

    Martinez, Vicent J

    2001-01-01

    Over the last decade, statisticians have developed new statistical tools in the field of spatial point processes. At the same time, observational efforts have yielded a huge amount of new cosmological data to analyze. Although the main tools in astronomy for comparing theoretical results with observation are statistical, in recent years, cosmologists have not been generally aware of the developments in statistics and vice versa.Statistics of the Galaxy Distribution describes both the available observational data on the distribution of galaxies and the applications of spatial statistics in cosmology. It gives a detailed derivation of the statistical methods used to study the galaxy distribution and the cosmological physics needed to formulate the statistical models. Because the prevalent approach in cosmological statistics has been frequentist, the authors focus on the most widely used of these methods, but they also explore Bayesian techniques that have become popular in large-scale structure studies.Describi...

  15. TRPV-1-mediated elimination of residual iPS cells in bioengineered cardiac cell sheet tissues

    Science.gov (United States)

    Matsuura, Katsuhisa; Seta, Hiroyoshi; Haraguchi, Yuji; Alsayegh, Khaled; Sekine, Hidekazu; Shimizu, Tatsuya; Hagiwara, Nobuhisa; Yamazaki, Kenji; Okano, Teruo

    2016-01-01

    The development of a suitable strategy for eliminating remaining undifferentiated cells is indispensable for the use of human-induced pluripotent stem (iPS) cell-derived cells in regenerative medicine. Here, we show for the first time that TRPV-1 activation through transient culture at 42 °C in combination with agonists is a simple and useful strategy to eliminate iPS cells from bioengineered cardiac cell sheet tissues. When human iPS cells were cultured at 42 °C, almost all cells disappeared by 48 hours through apoptosis. However, iPS cell-derived cardiomyocytes and fibroblasts maintained transcriptional and protein expression levels, and cardiac cell sheets were fabricated after reducing the temperature. TRPV-1 expression in iPS cells was upregulated at 42 °C, and iPS cell death at 42 °C was TRPV-1-dependent. Furthermore, TRPV-1 activation through thermal or agonist treatment eliminated iPS cells in cardiac tissues for a final concentration of 0.4% iPS cell contamination. These findings suggest that the difference in tolerance to TRPV-1 activation between iPS cells and iPS cell-derived cardiac cells could be exploited to eliminate remaining iPS cells in bioengineered cell sheet tissues, which will further reduce the risk of tumour formation. PMID:26888607

  16. TRPV-1-mediated elimination of residual iPS cells in bioengineered cardiac cell sheet tissues.

    Science.gov (United States)

    Matsuura, Katsuhisa; Seta, Hiroyoshi; Haraguchi, Yuji; Alsayegh, Khaled; Sekine, Hidekazu; Shimizu, Tatsuya; Hagiwara, Nobuhisa; Yamazaki, Kenji; Okano, Teruo

    2016-02-18

    The development of a suitable strategy for eliminating remaining undifferentiated cells is indispensable for the use of human-induced pluripotent stem (iPS) cell-derived cells in regenerative medicine. Here, we show for the first time that TRPV-1 activation through transient culture at 42 °C in combination with agonists is a simple and useful strategy to eliminate iPS cells from bioengineered cardiac cell sheet tissues. When human iPS cells were cultured at 42 °C, almost all cells disappeared by 48 hours through apoptosis. However, iPS cell-derived cardiomyocytes and fibroblasts maintained transcriptional and protein expression levels, and cardiac cell sheets were fabricated after reducing the temperature. TRPV-1 expression in iPS cells was upregulated at 42 °C, and iPS cell death at 42 °C was TRPV-1-dependent. Furthermore, TRPV-1 activation through thermal or agonist treatment eliminated iPS cells in cardiac tissues for a final concentration of 0.4% iPS cell contamination. These findings suggest that the difference in tolerance to TRPV-1 activation between iPS cells and iPS cell-derived cardiac cells could be exploited to eliminate remaining iPS cells in bioengineered cell sheet tissues, which will further reduce the risk of tumour formation.

  17. Statistical analysis of management data

    CERN Document Server

    Gatignon, Hubert

    2013-01-01

    This book offers a comprehensive approach to multivariate statistical analyses. It provides theoretical knowledge of the concepts underlying the most important multivariate techniques and an overview of actual applications.

  18. Methods for iPS cell generation for basic research and clinical applications.

    Science.gov (United States)

    Mochiduki, Yuji; Okita, Keisuke

    2012-06-01

    The induction of pluripotency can be achieved by forced expression of defined factors in somatic cells. The established cells, termed induced pluripotent stem (iPS) cells, have pluripotency and an infinite capacity for self-renewal in common with embryonic stem (ES) cells. Patient-specific iPS cells could be a useful source for drug discovery and cell transplantation therapies; however, the original method for iPS cell generation had several issues that were obstacles to their clinical application. Recent studies have brought about various improvements for iPS cell generation and uncovered several characteristics of iPS cells. Here we summarize the current status of iPS cell studies, with a focus on the improved methods that can be used to generate iPS cells, and also refer to the future challenges. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  19. CycloPs: generating virtual libraries of cyclized and constrained peptides including nonnatural amino acids.

    Science.gov (United States)

    Duffy, Fergal J; Verniere, Mélanie; Devocelle, Marc; Bernard, Elise; Shields, Denis C; Chubb, Anthony J

    2011-04-25

    We introduce CycloPs, software for the generation of virtual libraries of constrained peptides including natural and nonnatural commercially available amino acids. The software is written in the cross-platform Python programming language, and features include generating virtual libraries in one-dimensional SMILES and three-dimensional SDF formats, suitable for virtual screening. The stand-alone software is capable of filtering the virtual libraries using empirical measurements, including peptide synthesizability by standard peptide synthesis techniques, stability, and the druglike properties of the peptide. The software and accompanying Web interface is designed to enable the rapid generation of large, structurally diverse, synthesizable virtual libraries of constrained peptides quickly and conveniently, for use in virtual screening experiments. The stand-alone software, and the Web interface for evaluating these empirical properties of a single peptide, are available at http://bioware.ucd.ie .

  20. Statistics for Finance

    DEFF Research Database (Denmark)

    Lindström, Erik; Madsen, Henrik; Nielsen, Jan Nygaard

    Statistics for Finance develops students’ professional skills in statistics with applications in finance. Developed from the authors’ courses at the Technical University of Denmark and Lund University, the text bridges the gap between classical, rigorous treatments of financial mathematics...... that rarely connect concepts to data and books on econometrics and time series analysis that do not cover specific problems related to option valuation. The book discusses applications of financial derivatives pertaining to risk assessment and elimination. The authors cover various statistical...... and mathematical techniques, including linear and nonlinear time series analysis, stochastic calculus models, stochastic differential equations, Itō’s formula, the Black–Scholes model, the generalized method-of-moments, and the Kalman filter. They explain how these tools are used to price financial derivatives...

  1. Properties of Extruded PS-212 Type Self-Lubricating Materials

    Science.gov (United States)

    Waters, W. J.; Sliney, H. E.; Soltis, R. F.

    1993-01-01

    Research has been underway at the NASA Lewis Research Center since the 1960's to develop high temperature, self-lubricating materials. The bulk of the research has been done in-house by a team of researchers from the Materials Division. A series of self-lubricating solid material systems has been developed over the years. One of the most promising is the composite material system referred to as PS-212 or PM-212. This material is a powder metallurgy product composed of metal bonded chromium carbide and two solid lubricating materials known to be self-lubricating over a wide temperature range. NASA feels this material has a wide potential in industrial applications. Simplified processing of this material would enhance its commercial potential. Processing changes have the potential to reduce processing costs, but tribological and physical properties must not be adversely affected. Extrusion processing has been employed in this investigation as a consolidation process for PM-212/PS-212. It has been successful in that high density bars of EX-212 (extruded PM-212) can readily be fabricated. Friction and strength data indicate these properties have been maintained or improved over the P.M. version. A range of extrusion temperatures have been investigated and tensile, friction, wear, and microstructural data have been obtained. Results indicate extrusion temperatures are not critical from a densification standpoint, but other properties are temperature dependent.

  2. Preparations for Upgrading the RF Systems of the PS Booster

    CERN Document Server

    Albright, Simon; Shaposhnikova, Elena

    2016-01-01

    The accelerators of the LHC injector chain need to be upgraded to provide the HL-LHC beams. The PS Booster, the first synchrotron in the LHC injection chain, uses three different RF systems (first, second and up to tenth harmonic) in each of its four rings. As part of the LHC Injector Upgrade the current ferrite RF systems will be replaced with broadband Finemet cavities, increasing the flexibility of the RF system. A Finemet test cavity has been installed in Ring 4 to investigate its effect on machine performance, especially beam stability, during extensive experimental studies. Due to large space charge impedance Landau damping is lost through most of the cycle in single harmonic operation, but is recovered when using the second harmonic and controlled longitudinal emittance blow-up. This paper compares beam parameters during acceleration with and without the Finemet test cavity. Comparisons were made using beam measurements and simulations with the BLonD code based on a full PS Booster impedance model. Thi...

  3. KSR-based medium improves the generation of high-quality mouse iPS cells.

    Science.gov (United States)

    Liu, Kai; Wang, Fang; Ye, Xiaoying; Wang, Lingling; Yang, Jiao; Zhang, Jingzhuo; Liu, Lin

    2014-01-01

    Induced pluripotent stem (iPS) cells from somatic cells have great potential for regenerative medicine. The efficiency in generation of iPS cells has been significantly improved in recent years. However, the generation of high-quality iPS cells remains of high interest. Consistently, we demonstrate that knockout serum replacement (KSR)-based medium accelerates iPS cell induction and improves the quality of iPS cells, as confirmed by generation of chimeras and all iPS cell-derived offspring with germline transmission competency. Both alkaline phosphatase (AP) activity assay and expression of Nanog have been used to evaluate the efficiency of iPS cell induction and formation of ES/iPS cell colonies; however, appropriate expression of Nanog frequently indicates the quality of ES/iPS cells. Interestingly, whereas foetal bovine serum (FBS)-based media increase iPS cell colony formation, as revealed by AP activity, KSR-based media increase the frequency of iPS cell colony formation with Nanog expression. Furthermore, inhibition of MAPK/ERK by a specific inhibitor, PD0325901, in KSR- but not in FBS-based media significantly increases Nanog-GFP+ iPS cells. In contrast, addition of bFGF in KSR-based media decreases proportion of Nanog-GFP+ iPS cells. Remarkably, PD can rescue Nanog-GFP+ deficiency caused by bFGF. These data suggest that MAPK/ERK pathway influences high quality mouse iPS cells and that KSR- and PD-based media could enrich homogeneous authentic pluripotent stem cells.

  4. Imaging of irradiated human costal cartilage birefringence by PS-OCT

    Energy Technology Data Exchange (ETDEWEB)

    Martinho Junior, Antonio C.; Freitas, Anderson Z.; Santin, Stefany P.; Soares, Fernando A.N.; Mosca, Rodrigo C.; Bringel, Fabiana A.; Mathor, Monica B., E-mail: freitas.az@ipen.b, E-mail: rmosca@usp.b, E-mail: mathor@ipen.b [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2011-07-01

    Sterilization by ionizing radiation is a technique used for tissue banks around the world to avoid transmission of infectious diseases by human allografts. However, high doses of ionizing radiation may cause undesirable changes in tissue structure, decreasing its mechanical properties, for example. Optical Coherence Tomography (OCT) is a non destructive, non ionizing and real time method to investigate biological tissues without promote any change in tissue structure. Polarization Sensitive Optical Coherence Tomography (PS-OCT) is an OCT technique that combines polarimetry with low coherence reflectometry to provide depth resolved measurements from birefringent structures as collagen. Costal cartilages from 15 cadaveric donors were preserved in high concentration glycerol and each individual sample was divided in 6 fragments. One of them was kept as a control group and the others were irradiated with gamma radiation from a Co-60 source with doses of 15, 25, 50, 75 and 100 kGy. OCT and PS-OCT images of the same region of the samples were obtained from a device OCS 1300 SS (Thorlabs, USA) with a coupling polarization module PSOCT 1300 (Thorlabs, USA). According with our results, birefringence may be visualized in all test groups as well in the control group, suggesting that sterilization by ionizing radiation does not affect the collagen structure significantly to cause total loss of birefringence, even if high doses as 75 and 100 kGy are used. The next step of our work is to develop a new method to quantify the birefringence using the optical properties of the tissue. (author)

  5. The Poisson Distribution: An Experimental Approach to Teaching Statistics

    Science.gov (United States)

    Lafleur, Mimi S.; And Others

    1972-01-01

    Explains an experimental approach to teaching statistics to students who are essentially either non-science and non-mathematics majors or just beginning study of science. With every day examples, the article illustrates the method of teaching Poisson Distribution. (PS)

  6. Functional autoradiography shows unaltered cannabinoid CB1 receptor signalling in hippocampus and cortex of APP/PS1 transgenic mice.

    Science.gov (United States)

    Kärkkäine, E; Tanila, H; Laitinen, J T

    2012-12-01

    The cannabinoid CB1-receptor is among the most abundant G-protein-coupled receptors in the mammalian brain. Whereas post-mortem studies in Alzheimer's disease (AD) brains compared to age-matched controls have reported decreased CB1-receptor binding but no change in their protein levels (immunoreactivity), decreased or increased CB1- receptor protein levels have been reported in APP/PS1 transgenic mice modelling AD. To complete the picture, the present study used functional autoradiography to assess CB1-receptor-dependent G(i) protein activation in the hippocampus, entorhinal cortex and medial frontal cortex of 13- to 14-month-old female APPswe/PS1dE9 transgenic and wild-type littermate control mice. The mouse brains were processed for [³⁵S]GTPλS autoradiography so that brain sections were analysed in pairs of one transgenic and one control mouse brain. The autoradiography protocol was completed for each pair both in the absence and presence of dithiotreitol (DTT) to reveal possible redox-dependent alterations in CB1 receptor function. Five treatments were used: baseline, incubation with 10 μM GTPλS to assess nonspecific binding, and CB1 receptor agonist CP55,940 in three concentrations. By and large we found no statistically significant differences between the APP/PS1 transgenic and control mice in CB1 receptor signalling. The only exception was a modest redox-dependent alteration in entorhinal cortical CB1 receptors between the genotypes. Thus, in accordance with the majority of earlier human AD findings, we did not find evidence for notable changes in the number of functional CB1 receptors in the common APPswe/PS1dE9 mouse model of AD.

  7. Statistical inference a short course

    CERN Document Server

    Panik, Michael J

    2012-01-01

    A concise, easily accessible introduction to descriptive and inferential techniques Statistical Inference: A Short Course offers a concise presentation of the essentials of basic statistics for readers seeking to acquire a working knowledge of statistical concepts, measures, and procedures. The author conducts tests on the assumption of randomness and normality, provides nonparametric methods when parametric approaches might not work. The book also explores how to determine a confidence interval for a population median while also providing coverage of ratio estimation, randomness, and causal

  8. Acute application of TNF stimulates apical 70-pS K+ channels in the thick ascending limb of rat kidney.

    Science.gov (United States)

    Wei, Yuan; Babilonia, Elisa; Pedraza, Paulina L; Ferreri, Nicholas R; Wang, Wen-Hui

    2003-09-01

    TNF has been shown to be synthesized by the medullary thick ascending limb (mTAL) (21). In the present study, we used the patch-clamp technique to study the acute effect of TNF on the apical 70-pS K+ channel in the mTAL. Addition of TNF (10 nM) significantly stimulated activity of the 70-pS K+ channel and increased NPo [a product of channel open probability (Po) and channel number (N)] from 0.20 to 0.97. The stimulatory effect of TNF was observed only in cell-attached patches but not in excised patches. Moreover, addition of TNF had no effect on the ROMK-like small-conductance K+ channels in the TAL. The dose-response curve of the TNF effect yielded a Km value of 1 nM, a concentration that increased channel activity to 50% maximal stimulatory effect of TNF. The concentrations required for reaching the plateau of the TNF effect were between 5 and 10 nM. The stimulatory effect of TNF on the 70-pS K+ channel was observed in the presence of N(omega)-nitro-L-arginine methyl ester. This indicated that the effect of TNF was not mediated by a nitric oxide-dependent pathway. Also, inhibition of PKA did not affect the stimulatory effect of TNF. In contrast, inhibition of protein tyrosine kinase not only increased activity of the 70-pS K+ channel but also abolished the effect of TNF. Moreover, inhibition of protein tyrosine phosphatase (PTP) blocked the stimulatory effect of TNF on the 70-pS K+ channel. The notion that the TNF effect results from stimulation of PTP activity is supported by PTP activity assay in which treatment of mTAL cells with TNF significantly increased the activity of PTP. We conclude that TNF stimulates the 70-pS K+ channel via stimulation of PTP in the mTAL.

  9. The Plate Overlap Technique.

    Science.gov (United States)

    1978-07-31

    squares t h e o ry i i-, a v a i l a b l e to us and complete statistical rigor is sat is f l e d . In p a r t i ’ll a r , we knew t ha t l imK = k .p...S o l v i o ~, t h e Normal Equations I t w o u l d he ( ‘av ; , l l e r of us to remark t ha t the norma l t’qua ” ions a rt I i l l & ’ a

  10. Role of insulin receptor and insulin signaling on αPS2CβPS integrins' lateral diffusion.

    Science.gov (United States)

    Mainali, Dipak; Syed, Aleem; Arora, Neha; Smith, Emily A

    2014-12-01

    Integrins are ubiquitous transmembrane receptors with adhesion and signaling properties. The influence of insulin receptor and insulin signaling on αPS2CβPS integrins' lateral diffusion was studied using single particle tracking in S2 cells before and after reducing the insulin receptor expression or insulin stimulation. Insulin signaling was monitored by Western blotting for phospho-Akt expression. The expression of the insulin receptor was reduced using RNA interference (RNAi). After insulin receptor RNAi, four significant changes were measured in integrin diffusion properties: (1) there was a 24% increase in the mobile integrin population, (2) 14% of the increase was represented by integrins with Brownian diffusion, (3) for integrins that reside in confined zones of diffusion, there was a 45% increase in the diameter of the confined zone, and (4) there was a 29% increase in the duration integrins spend in confined zones of diffusion. In contrast to reduced expression of the insulin receptor, which alters integrin diffusion properties, insulin stimulation alone or insulin stimulation under conditions of reduced insulin receptor expression have minimal effects on altering the measured integrin diffusion properties. The differences in integrin diffusion measured after insulin receptor RNAi in the presence or absence of insulin stimulation may be the result of other insulin signaling pathways that are activated at reduced insulin receptor conditions. No change in the average integrin diffusion coefficient was measured for any conditions included in this study.

  11. Intuitive introductory statistics

    CERN Document Server

    Wolfe, Douglas A

    2017-01-01

    This textbook is designed to give an engaging introduction to statistics and the art of data analysis. The unique scope includes, but also goes beyond, classical methodology associated with the normal distribution. What if the normal model is not valid for a particular data set? This cutting-edge approach provides the alternatives. It is an introduction to the world and possibilities of statistics that uses exercises, computer analyses, and simulations throughout the core lessons. These elementary statistical methods are intuitive. Counting and ranking features prominently in the text. Nonparametric methods, for instance, are often based on counts and ranks and are very easy to integrate into an introductory course. The ease of computation with advanced calculators and statistical software, both of which factor into this text, allows important techniques to be introduced earlier in the study of statistics. This book's novel scope also includes measuring symmetry with Walsh averages, finding a nonp...

  12. Bayesian model selection techniques as decision support for shaping a statistical analysis plan of a clinical trial: An example from a vertigo phase III study with longitudinal count data as primary endpoint

    Directory of Open Access Journals (Sweden)

    Adrion Christine

    2012-09-01

    Full Text Available Abstract Background A statistical analysis plan (SAP is a critical link between how a clinical trial is conducted and the clinical study report. To secure objective study results, regulatory bodies expect that the SAP will meet requirements in pre-specifying inferential analyses and other important statistical techniques. To write a good SAP for model-based sensitivity and ancillary analyses involves non-trivial decisions on and justification of many aspects of the chosen setting. In particular, trials with longitudinal count data as primary endpoints pose challenges for model choice and model validation. In the random effects setting, frequentist strategies for model assessment and model diagnosis are complex and not easily implemented and have several limitations. Therefore, it is of interest to explore Bayesian alternatives which provide the needed decision support to finalize a SAP. Methods We focus on generalized linear mixed models (GLMMs for the analysis of longitudinal count data. A series of distributions with over- and under-dispersion is considered. Additionally, the structure of the variance components is modified. We perform a simulation study to investigate the discriminatory power of Bayesian tools for model criticism in different scenarios derived from the model setting. We apply the findings to the data from an open clinical trial on vertigo attacks. These data are seen as pilot data for an ongoing phase III trial. To fit GLMMs we use a novel Bayesian computational approach based on integrated nested Laplace approximations (INLAs. The INLA methodology enables the direct computation of leave-one-out predictive distributions. These distributions are crucial for Bayesian model assessment. We evaluate competing GLMMs for longitudinal count data according to the deviance information criterion (DIC or probability integral transform (PIT, and by using proper scoring rules (e.g. the logarithmic score. Results The instruments under study

  13. Water Atomization of Barium Fluoride: Calcium Fluoride for Enhanced Flow Characteristics of PS304 Feedstock Powder Blend

    Science.gov (United States)

    Stanford, Malcolm K.; DellaCorte, Christopher

    2003-01-01

    PS304 is a plasma spray deposited solid lubricant coating with feedstock composed of NiCr, Cr2O3, Ag, and BaF2-CaF2 powders. The effects of rounded BaF2-CaF2 particles on the gravity-fed flow characteristics of PS304 feedstock have been investigated. The BaF2-CaF2 powder was fabricated by water atomization using four sets of process parameters. Each of these powders was then characterized by microscopy and classified by screening to obtain 45 to 106 micron particles and added incrementally from 0 to 10 wt% to the other constituents of the PS304 feedstock, namely nichrome, chromia, and silver powders. The relationship between feedstock flow rate, measured with the Hall flowmeter, and concentration of fluorides was found to be linear in each case. The slopes of the lines were between those of the linear relationships previously reported using angular and spherical fluorides and were closer to the relationship predicted using the rule of mixtures. The results offer a fluoride fabrication technique potentially more cost-effective than gas atomization processes or traditional comminution processes.

  14. Assessment of Landslide Hazard Using PS-InSAR and Distinct Element Method: A Case Study in Central Taiwan

    Science.gov (United States)

    Tung, Y. H.; Hu, J. C.

    2016-12-01

    Our studies focus on the Gin-Yin Village, located at central Taiwan, where is an area vulnerable to landslide hazard. We adopted L-band ALOS SAR data to generate the line of sight (LOS) velocities in study area using PS-InSAR technique constrained by continuous GPS data in the period from 2007 to 2010. From the preliminary results of PS-InSAR, we noticed several LOS velocity trends related to potential landslides and a LOS velocity gap in the northeastern of the village. In addition, the borehole inclinometers installed by Central Geological Survey, recorded a slip depth more than 120 m just in the northeastern of the village. Based on the results of PS-InSAR, records of inclinometers and field geological study, we adopt 2-D and 3-D numerical simulations by using Particle Flow Code to investigate scenario-based runout paths, particle velocities and landslide-affected areas, which are useful information for decision support and future landslide hazard assessment. The area of the potential sliding slope is about 14 hectares, and the dipping of the potential sliding surface might be varied from 21 to 5 degree, the critical frictional coefficient to cause sliding would be 0.45. Once the slope slides, the buildings on the terrace may be destroyed or even be buried by debris within 60 seconds.

  15. Hydrogen sulfide down-regulates BACE1 and PS1 via activating PI3K/Akt pathway in the brain of APP/PS1 transgenic mouse.

    Science.gov (United States)

    He, Xuan-Li; Yan, Ning; Chen, Xiao-Shan; Qi, Yun-Wen; Yan, Yong; Cai, Zhiyou

    2016-10-01

    Endogenous hydrogen sulfide (H2S) may have multiple physiological functions in brain. Our previous study showed that H2S improved spatial memory impairment and decreased the production of Aβ in APP/PS1 transgenic mice. However, many of the underlying mechanisms are not still being elucidated. The aim of the present study is to investigate the neuroprotective mechanisms of H2S involving in the activity of β-secretase (BACE1), γ-secretase (PS1) and α-secretase (ADAM17). Morris water maze was used to measure the behavior change. The levels of Aβ40 and Aβ42 were quantified using colorimetric ELISA kits and immunohistochemical analysis. The levels of BACE1, PS1, ADAM17, pAkt, pp38MAPK, pERK and pJNK were tested by Western blot analysis in normal mice, APP/PS1 transgenic mice and 50μmol/kg-NaHS-treated transgenic mice. On the basis of exogenous H2S treatment, LY294002 (inhibitors of PI3K/Akt) or PD98059 (inhibitors of MAPK/ERK) was injected into lateral cerebral ventricle. The levels of BACE1, PS1 and pp38MAPK were increased and ADAM17 were decreased in the APP/PS1 transgenic mice. After intraperitoneal administration of an H2S donor (NaHS) into APP/PS1 mice, the levels of BACE1, PS1 and pp38MAPK were reduced and ADAM17 increased. The level of pp38 MAPKs, pAkt and pERK1/2 was increased in APP/PS1 transgenic mice compared with normal mice (ptransgenic mice and normal mice (p>0.05). These results demonstrated that LY294002 inhibited the effect of H2S on decreasing the BACE1 and PS1, reducing the level of Aβ and improving memory impairment in APP/PS1 transgenic mice. PD98059 had no influence on the expression of BACE1 and PS1. H2S inhibits the expression of BACE1 and PS1 by activating PI3K/Akt pathway in AD. Copyright © 2016 Institute of Pharmacology, Polish Academy of Sciences. Published by Elsevier Urban & Partner Sp. z o.o. All rights reserved.

  16. Engaging with the Art & Science of Statistics

    Science.gov (United States)

    Peters, Susan A.

    2010-01-01

    How can statistics clearly be mathematical and yet distinct from mathematics? The answer lies in the reality that statistics is both an art and a science, and both aspects are important for teaching and learning statistics. Statistics is a mathematical science in that it applies mathematical theories and techniques. Mathematics provides the…

  17. Development and characterization of sub-100 ps photomultiplier tubes.

    Science.gov (United States)

    Horsfield, C J; Rubery, M S; Mack, J M; Young, C S; Herrmann, H W; Caldwell, S E; Evans, S C; Sedilleo, T J; Kim, Y H; McEvoy, A; Milnes, J S; Howorth, J; Davis, B; O'Gara, P M; Garza, I; Miller, E K; Stoeffl, W; Ali, Z

    2010-10-01

    We describe the evaluation of a microchannel plate (MCP) photomultiplier tube (PMT), incorporating a 3 μm pore MCP and constant voltage anode and cathode gaps. The use of the small pore size results in PMTs with response functions of the order of 85 ps full-width-half-maximum, while the constant electric field across the anode and cathode gaps produces a uniform response function over the entire operating range of the device. The PMT was characterized on a number of facilities and employed on gas Cherenkov detectors fielded on various deuterium tritium fuel (DT) implosions on the Omega Laser Facility at the University of Rochester. The Cherenkov detectors are part of diagnostic development to measure Gamma ray reaction history for DT implosions on the National Ignition Facility.

  18. An Antiproton Decelerator in the CERN PS Complex

    CERN Document Server

    Riunaud, J P; Baird, S A; Boillot, J; Bosser, Jacques; Brouet, M; Caspers, Friedhelm; Chanel, M; Chohan, V; Eriksson, T; Garoby, R; Giannini, R; Giovannozzi, Massimo; Gruber, J; Hémery, J Y; Koziol, Heribert; MacCaferri, R; Maury, S; Metzmacher, K D; Möhl, D; Mulder, H; Pedersen, F; Perriollat, F; Poncet, Alain; Riunaud, J P; Serre, C; Simon, Daniel Jean; Tranquille, G; Tuyn, Jan Willem Nicolaas; Williams, B; Williams, D J

    1996-01-01

    The present CERN PS low-energy antiproton complex involves 4 machines to collect, cool, decelerate and supply experiments with up to 1010 antiprotons per pulse and per hour of momenta ranging from 0.1 to 2 GeV/c. In view of a possible future physics programme requiring low energy antiprotons, mainly to carry out studies on antihydrogen, a simplified scheme providing at low cost antiprotons at 100 MeV/c has been studied. It requires only one machine, the present Antiproton Collector (AC) converted into a cooler and decelerator (Antiproton Decelerator, AD) and delivering beam to experiments in the hall of the present Antiproton Accumulator Complex (AAC) [1]. This paper describes the feasibility study of such a scheme [2].

  19. MD on Head-Tail Instability in the PS Booster

    CERN Document Server

    Kornilov, V; Mikulec, B; Aumon, S; Rumolo, G

    2013-01-01

    Machine study experiments on the coherent instabilities appearing along the magnetic ramp have been performed at the CERN PS Booster synchrotron in the week of June 11-15, 2012. The space- and time structure of the head-tail instabilities was recorded by the triggered pick-up signals due to reproducibility of the occurrence time in the shot-by-shot sense. The intensity thresholds, the absolute growth rates and the mode structure have been compared for the bunches in the single-rf and in three types of the double-rf operation. The growth rates are compared to the instantaneous synchrotron frequencies, in the cases of the large corresponding ratio the head-tail mode structure is deformed by the driving impedance. Bunch parameters measurements indicate that the PSB bunches are in the regime of very strong transverse space-charge all along the magnetic ramp.

  20. Migrating the CERN PS control system to IBM workstations

    CERN Document Server

    De Metz-Noblat, N

    1995-01-01

    The workstations used within the control system of the CERN PS accelerator complex are not produced any more. We had therefore to review the software primary used as user interface and we achieved a port to IBM workstations. We are also preparing the maintenance of this code for the next ten years with minimal staff. This implies a clear separation between general computing facilities, control system developments, and operation. In order to share our experience, we will try to summarize various aspects of this migration: - system installation principles used to speed-up error recovery time and long-term maintenance costs, - problems correlated with the coexistence of two different platforms during migration, - software problems due to the platform and operating system changes, - hidden dependencies from a specific manufacturer.

  1. Multipole Stack for the 800 MeV PS Booster

    CERN Multimedia

    1975-01-01

    The 800 MeV PS Booster had seen first beam in its 4 superposed rings in 1972, routine operation began in 1973. In the strive for ever higher beam intensities, the need for additional multipole lenses became evident. After detailed studies, the manufacture of 8 stacks of multipoles was launched in 1974. Each stack consists of 4 superposed multipoles and each multipole has 4 concentric shells. From the innermost to the outermost shell, Type A contains octupole, skew-octupole, sextupole, skew-sextupole. Type B contains skew-octupole, skew-sextupole, vertical dipole, horizontal dipole. Completion of installation in 1976 opened the way to higher beam intensities. M. Battiaz is seen here with a multipole stack and its many electrical connections.

  2. First PS magnet unit, with members of the Magnet Group.

    CERN Multimedia

    CERN PhotoLab

    1956-01-01

    Members of the Magnet Group, sitting atop the first unit of the PS combined-function magnet. The picture was taken at the Institute of Physics of Geneva University, as CERN was still a muddy construction site at that time. All these people have now retired, but all of the magnets are still pulsing away. Front row (left to right): R.Tinguely, C.Germain, G.Plass, D.Neet, B.de Raad, M.Cavallaro, K.H.Reich, G.Kuhn, J.Nilsson, C.A.Ramm, Paillard. Second row: L.Resegotti, M.Niklaus, C.J.Zilverschoon, R.Bertolotto, Marcellin, G.Brianti, P.Collet. Standing behind: B.Kuiper.

  3. Surface morphology of PS-PDMS diblock copolymer films

    DEFF Research Database (Denmark)

    Andersen, T.H.; Tougaard, S.; Larsen, N.B.

    2001-01-01

    Spin coated thin films (∼400 Å) of poly(styrene)–poly(dimethylsiloxane) (PS–PDMS) diblock copolymers have been investigated using X-ray Photoelectron Spectroscopy and Atomic Force Microscopy. Surface segregation of the poly(dimethylsiloxane) blocks was studied for five diblock copolymers which...... by use of peak shape analysis of the X-ray Photoelectron Spectra via the Tougaard Method. The amount of dimethylsiloxane in the uppermost part of the films was quantified as a function of annealing time and temperature. For annealing above the PS glass transition temperature, surface segregation...... of the dimethylsiloxane chain-ends occurs for all the studied PS–PDMS diblock copolymers. At room temperature, surface segregation takes place only when the amount of dimethylsiloxane in the diblock copolymers is small....

  4. Small-size meshless 50 ps streak tube

    Science.gov (United States)

    Ageeva, N. V.; Andreev, S. V.; Belolipetski, V. S.; Bryukhnevich, G. I.; Greenfield, D. E.; Ivanova, S. R.; Kaverin, A. M.; Khohlova, A. N.; Kuz'menko, E. A.; Levina, G. P.; Makushina, V. A.; Monastyrskiy, M. A.; Schelev, M. Ya.; Semichastnova, Z. M.; Serdyuchenko, Yu. N.; Skaballanovich, T. A.; Sokolov, V. E.

    2008-11-01

    In contrast to the conventional image intensifier with large work area, a streak image tube should possess additional important feature - the comparatively small temporal distortion at the entire work area of the photocathode. With this additional engineering restriction taken into account, a novel small-size meshless streak image tube has been developed by means of numerical optimization. The tube with 25-mm wide work area contains a pair of deflection plates to sweep the electron image along the 25 mm output phosphor screen that is separated by 100 mm from the photocathode. The electron image can be shuttered with a 300 V blanking electric pulse. Electron-optical magnification of the tube is unit; spatial resolution reaches 30 lp/mm over the entire photocathode work area; temporal resolution lies in the 20 - 50 ps range, depending on the accelerating voltage (6 - 15 kV).

  5. Psödohipoparatiroidi Tip 1A: Olgu Sunumu

    Directory of Open Access Journals (Sweden)

    Mehmet Güven

    2017-06-01

    Full Text Available Psödohipoparatiroidizm (PHPT; hedef organın parathormona (PTH yanıt vermediği kalıtımsal bir bozukluktur. Biyokimyasal olarak; hipokalsemi, hiperfosfatemi ve PTH yüksekliği ile karakterizedir. PTH uygulamasına verilen yanıt belirgin derecede düşüktür. Tip 1A, biyokimyasal özelliklere ek olarak Albright herediter osteodistrofisi (AHO olarak bilinen karakteristik somatik bir fenotipe de sahiptir. Bu fenotipin, kısa boy, yuvarlak yüz, frontal bombelik, brakidaktili, obezite özelikleri bulunmaktadır. Burada biz, hipokalsemi ve Albright herediter osteodistrofisi tanısı koyduğumuz; kalsiyum, aktif D vitamini ile tedavi ettiğimiz olgumuzu sunduk.

  6. Tension free monofilament macropore polypropylene mesh (Gynemesh PS in female genital prolapse repair

    Directory of Open Access Journals (Sweden)

    Vicente Sola

    2006-08-01

    Full Text Available OBJECTIVES: To review intraoperative and postoperative complications associated to the correction of cystocele and rectocele with polypropylene mesh macropore monofilament (Gynemesh PS using transvaginal free tension technique. MATERIALS AND METHODS: Prospective study of patients that have been submitted to correction of cystocele and/or rectocele between November 2004 and August 2005 in the Urogynecology and Vaginal Surgery Unit of Gynecology and Obstetrics Department, Las Condes Clinic. Mesh was used in 31 patients: 9 for cystocele, 11 for rectocele, and 11 for concomitant meshes. Total mesh used 42. Media age 55 years old, weight 64 kilograms. In 7 patients we used a third mesh for correction of urinary incontinence by TVT-O technique. RESULTS: They did not present intraoperative complications, neither in immediate or delayed postoperative time. We did not observe hematoma, infection, erosion or exposition mesh. Healing of cystocele and rectocele was obtained in 100% of patients, with a pursuit between 1 and 8 months. DISCUSSION: The use of prosthetic polypropylene monofilament macropore mesh in the correction of cystocele and/or rectocele, by transvaginal route with tension free technique seems to be a safe and effective surgery procedure.

  7. A comparative study of dynamic soft tissue mobilization vs. passive stretching technique to improve the flexibility of hamstrings in cricket players.

    Science.gov (United States)

    Abbas, Mohsin; Bashir, Muhammad Salman; Noor, Rabiya

    2017-05-01

    Different therapies are available for correcting the tightness of hamstring muscles. Objective of this study was to compare the effectiveness of Dynamic Soft Tissue Mobilization DSTM technique and Passive Stretching PS to improve the flexibility of tight hamstrings in cricket players. A total of 120 cricket players having tightness of hamstrings were enrolled and randomized into two groups A and B using lottery method. Group-A was treated with DSTM and group-B with PS to improve the flexibility of hamstrings. Active Knee Extension Angle AKEA test was used to measure the hamstring tightness as it is a gold standard test for this purpose. The mean value of AKEA, pre-treatment score deficient to 180 degrees for DSTM was 25.66 ± 6.90, and that of PS was 25.46 ± 6.89, while the post-treatment score was 10.81 ± 4.30, and 18.63 ± 7.06 respectively. Post-treatment score for DSTM was statistically lower than PS. (p-value < 0.05). So it was concluded that it is better to use DSTM for acquiring better results.

  8. Using PS-InSAR data in landslide hazard management: the case of Veneto Region (NE Italy)

    Science.gov (United States)

    Floris, Mario; Viganò, Alessandro; Busnardo, Enrico; Arziliero, Luciano; Zanette, Doriano

    2013-04-01

    The Project Persistent Scatterers Interferometry, performed by the Italian Ministry of Environment and Territory of the Sea (METS) in the framework of the Extraordinary Plan of Environmental Remote Sensing, has made available a high quantity of data useful for local Authorities (Regions, Provinces, and Municipalities) in the management of the main geological hazards, such as landslides, subsidence, and sinkholes. The main output of the Project consists of ground displacements and velocities measured at target points over the entire Italian territory by using PS-InSAR processing technique applied to SAR data acquired by satellites ESA (European Space Agency) ERS-1 and ERS-2 (Earth Resources Satellite) and ENVISAT (Environmental Satellite) in the period 1992-2010. Description and results of the Project are available for public browsing at the geoportal of the METS (http://www.pcn.minambiente.it). On the basis of PS-InSAR data, several studies have been recently performed for the identification and characterization of landslides both at small and large scale. These studies led to a more precise delimitation of instable areas and to a better evaluation of the state of activity of mass movements. But, as now well known, interferometry techniques can't be applied to the whole territory due to geometric distortions in SAR data acquisition and to ground conditions. In this work we analyze the potentiality of PS-InSAR data from the Project Persistent Scatterers Interferometry in landslide hazard management of the Veneto Region, located in the north-eastern part of Italy. A synthetic description on the main features of landslides affecting the Region is reported, then the percentage of instabilities where PS-InSAR data can be used, is calculated. At the scale of the entire Region we suggest to follow the method proposed in the scientific literature to evaluate the state of activity of landslides on the basis of the measured velocities at the ground surface, while at local

  9. Computational statistics handbook with Matlab

    CERN Document Server

    Martinez, Wendy L

    2007-01-01

    Prefaces Introduction What Is Computational Statistics? An Overview of the Book Probability Concepts Introduction Probability Conditional Probability and Independence Expectation Common Distributions Sampling Concepts Introduction Sampling Terminology and Concepts Sampling Distributions Parameter Estimation Empirical Distribution Function Generating Random Variables Introduction General Techniques for Generating Random Variables Generating Continuous Random Variables Generating Discrete Random Variables Exploratory Data Analysis Introduction Exploring Univariate Data Exploring Bivariate and Trivariate Data Exploring Multidimensional Data Finding Structure Introduction Projecting Data Principal Component Analysis Projection Pursuit EDA Independent Component Analysis Grand Tour Nonlinear Dimensionality Reduction Monte Carlo Methods for Inferential Statistics Introduction Classical Inferential Statistics Monte Carlo Methods for Inferential Statist...

  10. Statistical methods for ranking data

    CERN Document Server

    Alvo, Mayer

    2014-01-01

    This book introduces advanced undergraduate, graduate students and practitioners to statistical methods for ranking data. An important aspect of nonparametric statistics is oriented towards the use of ranking data. Rank correlation is defined through the notion of distance functions and the notion of compatibility is introduced to deal with incomplete data. Ranking data are also modeled using a variety of modern tools such as CART, MCMC, EM algorithm and factor analysis. This book deals with statistical methods used for analyzing such data and provides a novel and unifying approach for hypotheses testing. The techniques described in the book are illustrated with examples and the statistical software is provided on the authors’ website.

  11. Statistical modeling for degradation data

    CERN Document Server

    Lio, Yuhlong; Ng, Hon; Tsai, Tzong-Ru

    2017-01-01

    This book focuses on the statistical aspects of the analysis of degradation data. In recent years, degradation data analysis has come to play an increasingly important role in different disciplines such as reliability, public health sciences, and finance. For example, information on products’ reliability can be obtained by analyzing degradation data. In addition, statistical modeling and inference techniques have been developed on the basis of different degradation measures. The book brings together experts engaged in statistical modeling and inference, presenting and discussing important recent advances in degradation data analysis and related applications. The topics covered are timely and have considerable potential to impact both statistics and reliability engineering.

  12. A statistical manual for chemists

    CERN Document Server

    Bauer, Edward

    1971-01-01

    A Statistical Manual for Chemists, Second Edition presents simple and fast statistical tools for data analysis of working chemists. This edition is organized into nine chapters and begins with an overview of the fundamental principles of the statistical techniques used in experimental data analysis. The subsequent chapters deal with the concept of statistical average, experimental design, and analysis of variance. The discussion then shifts to control charts, with particular emphasis on variable charts that are more useful to chemists and chemical engineers. A chapter focuses on the effect

  13. Statistics for lawyers

    CERN Document Server

    Finkelstein, Michael O

    2015-01-01

    This classic text, first published in 1990, is designed to introduce law students, law teachers, practitioners, and judges to the basic ideas of mathematical probability and statistics as they have been applied in the law. The third edition includes over twenty new sections, including the addition of timely topics, like New York City police stops, exonerations in death-sentence cases, projecting airline costs, and new material on various statistical techniques such as the randomized response survey technique, rare-events meta-analysis, competing risks, and negative binomial regression. The book consists of sections of exposition followed by real-world cases and case studies in which statistical data have played a role. The reader is asked to apply the theory to the facts, to calculate results (a hand calculator is sufficient), and to explore legal issues raised by quantitative findings. The authors' calculations and comments are given in the back of the book. As with previous editions, the cases and case stu...

  14. First observation of o-Ps to p-Ps transition and first direct measurement of positronium hyperfine splitting with sub-THz light

    Energy Technology Data Exchange (ETDEWEB)

    Yamazaki, Takayuki, E-mail: yamazaki@icepp.s.u-tokyo.ac.jp; Miyazaki, Akira; Suehara, Taikan; Namba, Toshio; Asai, Shoji; Kobayashi, Tomio [University of Tokyo, Department of Physics, Graduate School of Science, and International Center for Elementary Particle Physics (Japan); Saito, Haruo [University of Tokyo, Graduate School of Arts and Sciences (Japan); Urushizaki, Yuichi; Ogawa, Isamu; Idehara, Toshitaka [University of Fukui, Research Center for Development of Far-Infrared Region (Japan); Sabchevski, Svilen [Bulgarian Academy of Sciences (Bulgaria)

    2012-12-15

    Positronium is an ideal system for the research of the bound state QED. The hyperfine splitting of positronium (Ps-HFS, about 203 GHz) is an important observable but all previous measurements of Ps-HFS had been measured indirectly using Zeeman splitting. There might be the unknown systematic errors on the uniformity of magnetic field. We are trying to measure Ps-HFS directly using sub-THz radiation. We developed an optical system to accumulate high power (about 10 kW) radiation in a Fabry-Perot resonant cavity and observed the positronium hyperfine transition for the first time.

  15. Identification of heavy metals sources in the Mexico city atmosphere, using the proton induced x-ray analytical technique and multifactorial statistics techniques; Identificacion de fuentes de metales pesados en la atmosfera de la Ciudad de Mexico, usando la tecnica de analisis por induccion de rayos X con proton y tecnicas estadisticas multifactoriales

    Energy Technology Data Exchange (ETDEWEB)

    Hernandez M, B. [ININ, 52750 La Marquesa, Estado de Mexico (Mexico)

    1997-07-01

    The objectives of this work are: to identify the heavy metals present in the air, and its concentrations. To know the behavior from the polluting chemical elements to the long of an annual cycle corresponding to 1990, based on the concentrations of the same ones, obtained through the PIXE technique. To identify the suitable statistical methods to use to the data of metals concentration in form of total suspended particle (PST), found in this investigation. To relate the concentrations and the meteorological parameters considered to be able to suggest the possible pollution sources. In function of the obtained results, to serve as base to the decisions making and measures control that are planned by diverse institutions focused to the problem of the atmospheric pollution in the Metropolitan area of Mexico City (ZMCM). (Author)

  16. Human polymorphisms in nicotinic receptors: a functional analysis in iPS-derived dopaminergic neurons.

    Science.gov (United States)

    Deflorio, Cristina; Blanchard, Stéphane; Carisì, Maria Carla; Bohl, Delphine; Maskos, Uwe

    2017-02-01

    Tobacco smoking is a public health problem, with ∼5 million deaths per year, representing a heavy burden for many countries. No effective therapeutic strategies are currently available for nicotine addiction, and it is therefore crucial to understand the etiological and pathophysiological factors contributing to this addiction. The neuronal α5 nicotinic acetylcholine receptor (nAChR) subunit is critically involved in nicotine dependence. In particular, the human polymorphism α5D398N corresponds to the strongest correlation with nicotine dependence risk found to date in occidental populations, according to meta-analysis of genome-wide association studies. To understand the specific contribution of this subunit in the context of nicotine addiction, an efficient screening system for native human nAChRs is needed. We have differentiated human induced pluripotent stem (iPS) cells into midbrain dopaminergic (DA) neurons and obtained a comprehensive characterization of these neurons by quantitative RT-PCR. The functional properties of nAChRs expressed in these human DA neurons, with or without the polymorphism in the α5 subunit, were studied with the patch-clamp electrophysiological technique. Our results in human DA neurons carrying the polymorphism in the α5 subunit showed an increase in EC50, indicating that, in the presence of the polymorphism, more nicotine or acetylcholine chloride is necessary to obtain the same effect. This human cell culturing system can now be used in drug discovery approaches to screen for compounds that interact specifically with human native and polymorphic nAChRs.-Deflorio, C., Blanchard, S., Carisì, M. C., Bohl, D., Maskos, U. Human polymorphisms in nicotinic receptors: a functional analysis in iPS-derived dopaminergic neurons. © FASEB.

  17. Delay-line cables for the fast bumpers in the PS.

    CERN Multimedia

    CERN PhotoLab

    1976-01-01

    For 'continuous transfer' to the SPS, the beam accelerated in the PS is shaved off over several turns, so as to form a continuous sequence of bunches several times the length of the PS circumference. Fast bumpers, powered in a 'staircase' way, displace the PS beam stepwise towards the ejection septum. Each step lasts 2.1 microsec and the cable drums in this picture contain some of the bumper delay-lines of altogether 10 km.

  18. A DiPS+ case study: a self-healing RADIUS server

    OpenAIRE

    Michiels, Sam; Desmet, Lieven; Verbaeten, Pierre

    2004-01-01

    This report shows performance results of a RADIUS implementation using the DiPS+ software architecture. In addition it compares this implementation with a commercially available RADIUS implementation, and shows that the DiPS+ architecture differentiates between user types and request types. In fact, the DiPS+ prototype prioritizes incoming traffic based on application-specifc preferences, and allocates the available processing resources to the highest priority requests.

  19. Magnetic correlations in the 2D S=5/2 honeycomb antiferromagnet MnPS3

    DEFF Research Database (Denmark)

    Rønnow, H.M.; Wildes, A.R.; Bramwell, S.T.

    2000-01-01

    MnPS3 is a quasi-2D S = 5/2 antiferromagnet on a honeycomb lattice. Using an energy integrating neutron scattering technique, we have measured the structure factor S(k) of the instantaneous magnetic fluctuations. The temperature dependence of the correlation length xi follows the Kosterlitz-Thoul......-Thouless prediction with parameters that are consistently described by a Heisenberg system with inter plane coupling J'/'J = 1/405 and weak xy-anisotropy. (C) 2000 Elsevier Science B.V. All rights reserved....

  20. Predictors of Virological Response in 3,235 Chronic HCV Egyptian Patients Treated with Peginterferon Alpha-2a Compared with Peginterferon Alpha-2b Using Statistical Methods and Data Mining Techniques.

    Science.gov (United States)

    El Raziky, Maissa; Fathalah, Waleed Fouad; Zakaria, Zeinab; Eldeen, Hadeel Gamal; Abul-Fotouh, Amr; Salama, Ahmed; Awad, Abubakr; Esmat, Gamal; Mabrouk, Mahasen

    2016-05-01

    Despite the appearance of new oral antiviral drugs, pegylated interferon (PEG-IFN)/RBV may remain the standard of care therapy for some time, and several viral and host factors are reported to be correlated with therapeutic effects. This study aimed to reveal the independent variables associated with failure of sustained virological response (SVR) to PEG-IFN alpha-2a versus PEG-IFN alpha-2b in treatment of naive chronic hepatitis C virus (HCV) Egyptian patients using both statistical methods and data mining techniques. This retrospective cohort study included 3,235 chronic hepatitis C patients enrolled in a large Egyptian medical center: 1,728 patients had been treated with PEG-IFN alpha-2a plus ribavirin (RBV) and 1,507 patients with PEG-IFN alpha-2b plus RBV between 2007 and 2011. Both multivariate analysis and Reduced Error Pruning Tree (REPTree)-based model were used to reveal the independent variables associated with treatment response. In both treatment types, alpha-fetoprotein (AFP) >10 ng/mL and HCV viremia >600 × 10(3) IU/mL were the independent baseline variables associated with failure of SVR, while male gender, decreased hemoglobin, and thyroid-stimulating hormone were the independent variables associated with good response (P 10 ng/mL and viral load >600 × 10(3) IU/mL are variables associated with failure of response in both treatment types. REPTree-based model could be used to assess predictors of response.

  1. Facile Synthesis of Mono-Dispersed Polystyrene (PS/Ag Composite Microspheres via Modified Chemical Reduction

    Directory of Open Access Journals (Sweden)

    Wen Zhu

    2013-12-01

    Full Text Available A modified method based on in situ chemical reduction was developed to prepare mono-dispersed polystyrene/silver (PS/Ag composite microspheres. In this approach; mono-dispersed PS microspheres were synthesized through dispersion polymerization using poly-vinylpyrrolidone (PVP as a dispersant at first. Then, poly-dopamine (PDA was fabricated to functionally modify the surfaces of PS microspheres. With the addition of [Ag(NH32]+ to the PS dispersion, [Ag(NH32]+ complex ions were absorbed and reduced to silver nanoparticles on the surfaces of PS-PDA microspheres to form PS/Ag composite microspheres. PVP acted both as a solvent of the metallic precursor and as a reducing agent. PDA also acted both as a chemical protocol to immobilize the silver nanoparticles at the PS surface and as a reducing agent. Therefore, no additional reducing agents were needed. The resulting composite microspheres were characterized by TEM, field emission scanning electron microscopy (FESEM, energy-dispersive X-ray spectroscopy (EDS, XRD, UV-Vis and surface-enhanced Raman spectroscopy (SERS. The results showed that Ag nanoparticles (NPs were homogeneously immobilized onto the PS microspheres’ surface in the presence of PDA and PVP. PS/Ag composite microspheres were well formed with a uniform and compact shell layer and were adjustable in terms of their optical property.

  2. Lehtmets : psühhiaatria ei ole piisavalt atraktiivne / Andres Lehtmets ; interv. Marika Kusnets

    Index Scriptorium Estoniae

    Lehtmets, Andres

    2004-01-01

    Vestlus Eesti Psühhiaatrite Seltsi aseesimehega rahva vaimsest tervisest. Samas ka sotsiaalministeeriumi rahvatervise osakonna peaspetsialisti Helja Eomoisi kommentaar: Mida teeb ministeerium rahva vaimse tervise parandamiseks?

  3. Morphological Analysis for Statistical Machine Translation

    National Research Council Canada - National Science Library

    Lee, Young-Suk

    2004-01-01

    We present a novel morphological analysis technique which induces a morphological and syntactic symmetry between two languages with highly asymmetrical morphological structures to improve statistical...

  4. Introductory statistics for engineering experimentation

    CERN Document Server

    Nelson, Peter R; Coffin, Marie

    2003-01-01

    The Accreditation Board for Engineering and Technology (ABET) introduced a criterion starting with their 1992-1993 site visits that "Students must demonstrate a knowledge of the application of statistics to engineering problems." Since most engineering curricula are filled with requirements in their own discipline, they generally do not have time for a traditional two semesters of probability and statistics. Attempts to condense that material into a single semester often results in so much time being spent on probability that the statistics useful for designing and analyzing engineering/scientific experiments is never covered. In developing a one-semester course whose purpose was to introduce engineering/scientific students to the most useful statistical methods, this book was created to satisfy those needs. - Provides the statistical design and analysis of engineering experiments & problems - Presents a student-friendly approach through providing statistical models for advanced learning techniques - Cove...

  5. Molecular characterization of plasmids pS7a and pS7b from Lactococcus lactis subsp. lactis bv. diacetylactis S50 as a base for the construction of mobilizable cloning vectors.

    Science.gov (United States)

    Strahinic, I; Kojic, M; Tolinacki, M; Fira, D; Topisirovic, L

    2009-01-01

    Strain Lactococcus lactis subsp. lactis bv. diacetylactis S50 harbours five theta-replicating plasmids (pS6, pS7a, pS7b, pS80 and pS140). The aim of this study was to characterize domains involved in the replication and conjugative mobilization of the small plasmids pS7a and pS7b, which are structurally very similar. Complete nucleotide sequences of pS7a and pS7b were determined by cloning DNA fragments of different sizes into Escherichia coli vectors. Linearized plasmids and four EcoRI fragments of the pS7a and pS7b were cloned into an origin probe vector. Constructed plasmids (pSEV10, pSK10, pISE1a and pISE1b) were able to replicate in the strain L. lactis subsp. cremoris MG1363. In addition, experiments showed that plasmids pS7a and pS7b contained oriT sequences and their conjugative transfer directly depended on the presence of pS80 in donor cells. Plasmids pS7a and pS7b contained typical lactococcal theta replication origin and repB gene that enable them to replicate in the strain L. lactis subsp. cremoris MG1363. Plasmid pS80 plays a key role in the conjugative transfer of small plasmids. Plasmids pS7a and pS7b-based derivatives could be valuable tools for genetic manipulation, studying processes of plasmid maintenance and horizontal gene transfer in lactococci.

  6. On quantum statistical inference

    DEFF Research Database (Denmark)

    Barndorff-Nielsen, Ole Eiler; Gill, Richard D.; Jupp, Peter E.

    Recent developments in the mathematical foundations of quantum mechanics have brought the theory closer to that of classical probability and statistics. On the other hand, the unique character of quantum physics sets many of the questions addressed apart from those met classically in stochastics....... Furthermore, concurrent advances in experimental techniques and in the theory of quantum computation have led to a strong interest in questions of quantum information, in particular in the sense of the amount of information about unknown parameters in given observational data or accessible through various...

  7. Statistics for Finance

    DEFF Research Database (Denmark)

    Lindström, Erik; Madsen, Henrik; Nielsen, Jan Nygaard

    that rarely connect concepts to data and books on econometrics and time series analysis that do not cover specific problems related to option valuation. The book discusses applications of financial derivatives pertaining to risk assessment and elimination. The authors cover various statistical...... and mathematical techniques, including linear and nonlinear time series analysis, stochastic calculus models, stochastic differential equations, Itō’s formula, the Black–Scholes model, the generalized method-of-moments, and the Kalman filter. They explain how these tools are used to price financial derivatives...

  8. Neural stem cells differentiated from iPS cells spontaneously regain pluripotency.

    Science.gov (United States)

    Choi, Hyun Woo; Kim, Jong Soo; Choi, Sol; Hong, Yean Ju; Kim, Min Jung; Seo, Han Geuk; Do, Jeong Tae

    2014-10-01

    Differentiated somatic cells can be reprogrammed into pluripotent stem cells by transduction of exogenous reprogramming factors. After induced pluripotent stem (iPS) cells are established, exogenous genes are silenced. In the pluripotent state, retroviral genes integrated in the host genome are kept inactive through epigenetic transcriptional regulation. In this study, we tried to determine whether exogenous genes remain silenced or are reactivated upon loss of pluripotency or on differentiation using an in vitro system. We induced differentiation of iPS cells into neural stem cells (NSCs) in vitro; the NSCs appeared morphologically indistinguishable from brain-derived NSCs and stained positive for the NSC markers Nestin and Sox2. These iPS cell-derived NSCs (iPS-NSCs) were also capable of differentiating into all three neural subtypes. Interestingly, iPS-NSCs spontaneously formed aggregates on long-term culture and showed reactivation of the Oct4-GFP marker, which was followed by the formation of embryonic stem cell-like colonies. The spontaneously reverted green fluorescent protein (GFP)-positive (iPS-NSC-GFP(+) ) cells expressed high levels of pluripotency markers (Oct4 and Nanog) and formed germline chimeras, indicating that iPS-NSC-GFP(+) cells had the same pluripotency as the original iPS cells. The reactivation of silenced exogenous genes was tightly correlated with the downregulation of DNA methyltransferases (Dnmts) during differentiation of iPS cells. This phenomenon was not observed in doxycycline-inducible iPS cells, where the reactivation of exogenous genes could be induced only by doxycycline treatment. These results indicate that pluripotency can be regained through reactivation of exogenous genes, which is associated with dynamic change of Dnmt levels during differentiation of iPS cells. © 2014 AlphaMed Press.

  9. Phosphorene-directed self-assembly of asymmetric PS-b-PMMA block copolymer for perpendicularly-oriented sub-10 nm PS nanopore arrays

    Science.gov (United States)

    Zhang, Ziming; Zheng, Lu; Khurram, Muhammad; Yan, Qingfeng

    2017-10-01

    Few-layer black phosphorus, also known as phosphorene, is a new two-dimensional material which is of enormous interest for applications, mainly in electronics and optoelectronics. Herein, we for the first time employ phosphorene for directing the self-assembly of asymmetric polystyrene-block-polymethylmethacrylate (PS-b-PMMA) block copolymer (BCP) thin film to form the perpendicular orientation of sub-10 nm PS nanopore arrays in a hexagonal fashion normal to the interface. We experimentally demonstrate that none of the PS and PMMA blocks exhibit preferential affinity to the phosphorene-modified surface. Furthermore, the perpendicularly-oriented PS nanostructures almost stay unchanged with the variation of number of layers of few-layer phosphorene nanoflakes between 15-30 layers. Differing from the neutral polymer brushes which are widely used for chemical modification of the silicon substrate, phosphorene provides a novel physical way to control the interfacial interactions between the asymmetric PS-b-PMMA BCP thin film and the silicon substrate. Based on our results, it is possible to build a new scheme for producing sub-10 nm PS nanopore arrays oriented perpendicularly to the few-layer phosphorene nanoflakes. Furthermore, the nanostructural microdomains could serve as a promising nanolithography template for surface patterning of phosphorene nanoflakes.

  10. Beam lines from Linac 1 to PS and Booster

    CERN Multimedia

    CERN PhotoLab

    1978-01-01

    View against the direction of the proton beams. The 50 MeV Linac 1 is behind the concrete wall. Its beam emerges from the hole near the centre of the picture. A switching magnet directs the beam either to the PS (to the right in the sense of the beam; original injection line), or lets it go straight on to the Booster (originally 800 MeV, now 1.4 GeV). The huge drum in the line to the Booster is a "debuncher", driven by the 200 MHz RF of the linac. It reduces the beam's momentum spread. This was the last year of Linac 1 as provider of protons to the Booster. Linac 2, nearly completed at the time of this picture, took up trial delivery at the end of 1978, and routine delivery in 1979. The beam line from Linac 2, barely visible here, can be clearly seen on 7802260. Linac 1 had a second life as an ion accelerator.

  11. The (7,7) optics at CERN PS

    CERN Document Server

    Serluca, M; Efthymiopoulos, I; Sperati, F; Sterbini, G; Tecker, F; Zisopoulos, P

    2017-01-01

    The PS lattice is composed by one hundred combinedfunction magnets, which set the bare tune of the machineto (Qh,Qv) = (6.25, 6.28). Low energy quadrupoles areused at injection to move the tune in a limited working pointarea. In particular the vertical tune is moved below 6.25 toavoid the structural resonance 8Qv= 50 coupled with spacecharge, which leads to strong losses. In view of the highdemands in terms of beam brightness for LIU and HL-LHCprojects, the interest of exploring different integer tune work-ing area started during last years. During 2016, for the firsttime, it has been possible to explore the (7,7) tune workingarea at injection using the auxiliary circuits of the combinedfunction magnets. A finite-element magnetic model, underdevelopment, has been used to predict the required currentsin order to get the desired optical parameters. In this pa-per we present the results and issues encountered duringthe Machine Development (MD) studies about the injectionin the (7,7) area along with optics and be...

  12. Injection Bump Synchronization Study for the CERN PS

    CERN Document Server

    Serluca, Maurizio; Gilardoni, Simone; CERN. Geneva. ATS Department

    2016-01-01

    In the framework of the LHC Injector Upgrade (LIU) project the CERN PS injection kinetic energy will be upgraded from 1.4 to 2 GeV. The present injection bump is made by four bumpers in Straight Section (SS) 40, 42, 43, 44 and it will be converted in a five bumpers system to allow additional flexibility in the bump shape with a reduction of the proton losses during the bump closure. The injection section SS42 has being redesigned to accommodate a new eddy current septum which will host a new bumper magnet in the same vacuum vessel due to reduced longitudinal space availability. The synchronization and amplitude variation of the power converter of the in-vacuum bumper 42 with respect to the remaining outside vacuum bumpers 40, 41, 43, 44 can lead to orbit distortion and consequent losses during injection. In this note we present the experimental results from Machine Development (MD) studies along with simulations for the present system at 1.4 GeV to quantify the acceptable orbit distortion and the performance ...

  13. Scanning SQUID sampler with 40-ps time resolution

    Science.gov (United States)

    Cui, Zheng; Kirtley, John R.; Wang, Yihua; Kratz, Philip A.; Rosenberg, Aaron J.; Watson, Christopher A.; Gibson, Gerald W.; Ketchen, Mark B.; Moler, Kathryn. A.

    2017-08-01

    Scanning Superconducting QUantum Interference Device (SQUID) microscopy provides valuable information about magnetic properties of materials and devices. The magnetic flux response of the SQUID is often linearized with a flux-locked feedback loop, which limits the response time to microseconds or longer. In this work, we present the design, fabrication, and characterization of a novel scanning SQUID sampler with a 40-ps time resolution and linearized response to periodically triggered signals. Other design features include a micron-scale pickup loop for the detection of local magnetic flux, a field coil to apply a local magnetic field to the sample, and a modulation coil to operate the SQUID sampler in a flux-locked loop to linearize the flux response. The entire sampler device is fabricated on a 2 mm × 2 mm chip and can be scanned over macroscopic planar samples. The flux noise at 4.2 K with 100 kHz repetition rate and 1 s of averaging is of order 1 mΦ0. This SQUID sampler will be useful for imaging dynamics in magnetic and superconducting materials and devices.

  14. The directed differentiation of human iPS cells into kidney podocytes.

    Directory of Open Access Journals (Sweden)

    Bi Song

    Full Text Available The loss of glomerular podocytes is a key event in the progression of chronic kidney disease resulting in proteinuria and declining function. Podocytes are slow cycling cells that are considered terminally differentiated. Here we provide the first report of the directed differentiation of induced pluripotent stem (iPS cells to generate kidney cells with podocyte features. The iPS-derived podocytes share a morphological phenotype analogous with cultured human podocytes. Following 10 days of directed differentiation, iPS podocytes had an up-regulated expression of mRNA and protein localization for podocyte markers including synaptopodin, nephrin and Wilm's tumour protein (WT1, combined with a down-regulation of the stem cell marker OCT3/4. In contrast to human podocytes that become quiescent in culture, iPS-derived cells maintain a proliferative capacity suggestive of a more immature phenotype. The transduction of iPS podocytes with fluorescent labeled-talin that were immunostained with podocin showed a cytoplasmic contractile response to angiotensin II (AII. A permeability assay provided functional evidence of albumin uptake in the cytoplasm of iPS podocytes comparable to human podocytes. Moreover, labeled iPS-derived podocytes were found to integrate into reaggregated metanephric kidney explants where they incorporated into developing glomeruli and co-expressed WT1. This study establishes the differentiation of iPS cells to kidney podocytes that will be useful for screening new treatments, understanding podocyte pathogenesis, and offering possibilities for regenerative medicine.

  15. Emission properties of porphyrin compounds in new polymeric PS:CBP host

    Science.gov (United States)

    Jafari, Mohammad Reza; Bahrami, Bahram

    2015-06-01

    In this study, a device with fundamental structure of ITO/PEDOT:PSS (60 nm)/PS:CBP (70 nm)/Al (150 nm) was fabricated. The electroluminescence spectrum of device designated a red shift rather than PS:CBP photoluminescence spectra. It can be suggested that the electroplex emission occurs at PS:CBP interface. By following this step, red light-emitting devices using porphyrin compounds as a red dopant in a new host material PS:CBP with a configuration of ITO/PEDOT:PSS (60 nm)/PS:CBP:porphyrin compounds(70 nm)/Al (150 nm) have been fabricated and investigated. The electroluminescent spectra of the porphyrin compounds were red-shifted as compared with the PS:CBP blend. OLED devices based on doping 3,4PtTPP and TPPNO2 in PS:CBP showed purer red emission compared with ZnTPP and CoTPP doped devices. We believe that the electroluminescence performance of OLED devices based on porphyrin compounds depends on overlaps between the absorption of the porphyrin compounds and the emission of PS:CBP.

  16. Composite Si/PS membrane pressure sensors with micro and macro ...

    Indian Academy of Sciences (India)

    Porous Silicon (PS) is a versatile material with many unique features making it viable in the field of Microelectromechanical Systems (MEMS). In this paper, we discuss the optimization of formation parameters of micro and macro PS with different porosity and thickness for use in pressure sensors. The optimized material is ...

  17. [Methionine metabolism regulates maintenance and differentiation of human ES/iPS cells].

    Science.gov (United States)

    Shiraki, Nobuaki; Kume, Shoen

    2015-05-01

    Embryonic stem (ES) and induced pluripotent stem (iPS) cells are pluripotent and can give rise to all cell types. ES/iPS cells have a unique transcriptional circuit that sustains the pluripotent state. These cells also possess a characteristically high rate of proliferation as well as an abbreviated G1 phase. These unique molecular properties distinguish ES and iPS cells from somatic cells. Mouse ES/iPS cells are in a high-flux metabolic state, with a high dependence on threonine catabolism. However, little is known about amino acid metabolism in human ES/iPS cells. Recently, we reported that human ES/iPS cells require high amounts of methionine (Met) and express high levels of Met metabolism enzymes (Shriaki N, et al: Cell Metabolism, 2014). Met deprivation results in a rapid decrease in intracellular S-adenosyl-methionine (SAM), triggering the activation of p53 signaling, reducing pluripotent marker gene NANOG expression, and poising human ES/iPS cells for differentiation, follow by potentiated differentiation into all three germ layers. However, when exposed to prolonged Met deprivation, the cells went to apoptosis. In this review, we explain the importance of SAM in Met metabolism and its relationship with pluripotency, cell survival, and differentiation of human ES/iPS cells.

  18. 7 CFR 1753.37 - Plans and specifications (P&S).

    Science.gov (United States)

    2010-01-01

    ....37 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE... Installation of Central Office Equipment § 1753.37 Plans and specifications (P&S). (a) General. (1) Prior to... central office equipment. (2) The P&S shall specify the delivery and completion time required for each...

  19. Rahuoperatsioonide Keskuses alustab sotsiaalse ja psühholoogilise toetuse sektsioon / Merle Tihaste, Marge Sillaste

    Index Scriptorium Estoniae

    Parmak, Merle, 1968-

    2008-01-01

    Missioonidel osalevatele või pikaajalises lähetuses viibivatele kaitseväelastele ja nende peredele suunatud sotsiaalse ja psühholoogilise toetuse tagamiseks loodud sektsioonist Rahuoperatsioonide Keskuse koosseisus. Sektsiooni töömudelist, ülesannetest ja koostöövõrgustikust. Skeem: Sotsiaalse ja psühholoogilise toetuse sektsiooni töömudel ja partnerid

  20. PS Dreyer: Bakens op die pad van die wetenskap | Antonites | HTS ...

    African Journals Online (AJOL)

    PS Dreyer: Beacons on the path of science. Professor PS Dreyer is an academic who has shovsm insight and vision into several problems of the human sciences since 1951. He has identified problems, but also contributed solutions to them. In this respect his philosophy on causality and freedom is of utmost importance.